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<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JF88</accession>
    <name>A0A2M9JF88_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GNAT family N-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_43940</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000045">
        <property type="protein sequence ID" value="PJN05561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN05561">
        <property type="protein sequence ID" value="PJN05561"/>
        <property type="gene ID" value="CG723_43940"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN05561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="152" mass="16871" checksum="D8BAFA7553547ED5" modified="2018-04-25" version="1">MPIRAVRLDELPVLQDIERAAGQCFRDIGMPEIAEDEPLPLGELARYHHAGMAWVVAIDSDAPFAYMIADRFDGNLHVEQVSVHPDSARRGVGRLLLEHLASHARSEGAPALTLATFTQVPWNAPYYSRCGFHGCRCGGSGDVRRRRLRGRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-09-29" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JFH5</accession>
    <name>A0A2M9JFH5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CG723_43860</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000044">
        <property type="protein sequence ID" value="PJN05638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN05638">
        <property type="protein sequence ID" value="PJN05638"/>
        <property type="gene ID" value="CG723_43860"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011067">
        <property type="entry name" value="Plasmid_toxin/cell-grow_inhib"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PJN05638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="98" mass="10476" checksum="30C70AC68159FE4F" modified="2018-04-25" version="1">MKRGDVWSLPDERHVLVVSLSGLDEAYGAVLGLVLHPAGRYPDTAMSVGIDTPIPCTAVAVNLQQLRAVRFAEATHQGTVDPATMARVDQALRAVLDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-09-29" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JG20</accession>
    <name>A0A2M9JG20_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="11">RNA helicase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CG723_42610</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000040">
        <property type="protein sequence ID" value="PJN05829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN05829">
        <property type="protein sequence ID" value="PJN05829"/>
        <property type="gene ID" value="CG723_42610"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3 11" id="KW-0347">Helicase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Q_MOTIF" evidence="10">
        <location>
            <begin position="53"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="8">
        <location>
            <begin position="84"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="9">
        <location>
            <begin position="268"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="510"/>
            <end position="752"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="444"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="5">
        <location>
            <begin position="53"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="526"/>
            <end position="730"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PJN05829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="752" mass="81636" checksum="56FD4E6E8DFC8384" modified="2018-04-25" version="1">MSISSSDHTVMPENDEAVQVLAVDEDVTAVAVGEAADSASAEADTDTPAEPTLTFGDLGLPEGIVRKLAQNGVTAPFPIQAATIPDALAGKDILGRGRTGSGKTLSFGLPTLARLAGGHTEKKKPRAVILTPTRELAMQVADALQPYGDVLGLKMKVVCGGTSMGNQIYALERGVDVLVATPGRLRDIINRGACSLENVEIAVLDEADQMSDLGFLPEVTELLDQVPADGQRMLFSATMENEISTLVKRYLTNPVTHEVDAAQGAVTTMTHHILIVKPKDKAPVTAAIASRKGRTIIFVRTQLGADRIAEQLQDAGVKADALHGGMTQGSRTRVLADFKDGYVNTLVATDVAARGIHVDGIDLVLNVDPAGDHKDYLHRSGRTARAGKSGVVVSLSLPHQRRQIFRLMEDAGVDASRHIIQGGAAFDPEVAEITGARSMTEVQAESAGNAAQQAEREVTSLTKELERATRRAGELREEADRLTARAARERGEDAEGVAAAVAAAAEKAAEASVPEQAAAPAERQERSSSYEQRPQRRDERGNYEKRDRRDDRPSGGFNRDRRDNDRGGFRRDDRPSGGGFNRDRRDERPSGGGFRRDDRPSGGGFNRDRRDDNRGGFDRDRRDDRGGRSFERRDNDRPSGGFRRDNDRPSGGFNRDRRDDRPSGGGFNRDRRDERPSGGGFRRDDRPSGGHRGSDRPFNRDRRDDRPAGGGFRSGGHDRPYGRRDDHRGAGSGSTGGSSFRRDEKPRWKRNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-05-25" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JG53</accession>
    <name>A0A2M9JG53_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DNA-binding response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CG723_42220</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000039">
        <property type="protein sequence ID" value="PJN05858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030045455.1">
        <property type="nucleotide sequence ID" value="NZ_NNBL01000039.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN05858">
        <property type="protein sequence ID" value="PJN05858"/>
        <property type="gene ID" value="CG723_42220"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00383">
        <property type="entry name" value="trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="3">
        <location>
            <begin position="4"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="domain" description="OmpR/PhoB-type" evidence="4">
        <location>
            <begin position="125"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="2">
        <location>
            <begin position="125"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PJN05858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="225" mass="24780" checksum="1F063884B6C06107" modified="2018-04-25" version="1">MKGRVLVVDDDTALAEMLGIVLRGEGFEPSFVADGDKALAAFRESKPDLVLLDLMLPGRDGIEVCRLIRAESGVPIVMLTAKSDTVDVVVGLESGADDYIVKPFKPKELVARIRARLRRSEEPAPEQLAIGDLVIDVAGHSVKREGQSIALTPLEFDLLVALARKPWQVFTREVLLEQVWGYRHAADTRLVNVHVQRLRSKVEKDPERPEIVVTVRGVGYKAGPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JG66</accession>
    <name>A0A2M9JG66_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Tellurite resistance TerB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_42630</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000040">
        <property type="protein sequence ID" value="PJN05832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN05832">
        <property type="protein sequence ID" value="PJN05832"/>
        <property type="gene ID" value="CG723_42630"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3680.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007791">
        <property type="entry name" value="DjlA_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029024">
        <property type="entry name" value="TerB-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05099">
        <property type="entry name" value="TerB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158682">
        <property type="entry name" value="SSF158682"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TerB" evidence="1">
        <location>
            <begin position="32"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN05832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="151" mass="16587" checksum="A7841C09C7DF064C" modified="2018-04-25" version="1">MALWDRFKESASTMQTQLMAKKNDLKSGAFRDASMAMCALVAAADRNIDPAERSRVAQLISTNEVLQNFPADQLQSRFDANLNKLTADFDFGKVSVLQEIAKAKKKPAEARAVIQIGIVIGGADGDFDKTEQAVVREACLMLDLPPHEFDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JGN9</accession>
    <name>A0A2M9JGN9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CG723_41330</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000036">
        <property type="protein sequence ID" value="PJN06046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN06046">
        <property type="protein sequence ID" value="PJN06046"/>
        <property type="gene ID" value="CG723_41330"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PJN06046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="118" mass="13024" checksum="B40A8C65BBD9C893" modified="2018-04-25" version="1">MPHNVSGKSIEITGASVVDPPKGLKVLGYAAYNVNDTEGLPLLALGGESDTPDFAHLKDYAKSEVKVSPKKQSEIFFQAKIRITSPPKKNIEHCQFQYRQGGQEFTQILDCEMELKVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JGU6</accession>
    <name>A0A2M9JGU6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CG723_40870</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000035">
        <property type="protein sequence ID" value="PJN06104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN06104">
        <property type="protein sequence ID" value="PJN06104"/>
        <property type="gene ID" value="CG723_40870"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PJN06104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="159" mass="16983" checksum="42BC6CEAD3543053" modified="2018-04-25" version="1">MNLHHAVEITLTRPATHDELAHAARTLPLAANHDATRLMTVVHAKTPGRALHRVRGRLREALPVDVITTHYPDSSGHVLLNITLSPSADAAVCQAADRAGQTRRIFVRLALRKALAQHVEEEASLLDSAVQRLLATTTASQLLAAVGRALTPTPGAPSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JGW5</accession>
    <name>A0A2M9JGW5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">CRISPR-associated endonuclease Cas3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CG723_40810</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CB01635</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">In the N-terminal section; belongs to the CRISPR-associated nuclease Cas3-HD family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">In the central section; belongs to the CRISPR-associated helicase Cas3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000035">
        <property type="protein sequence ID" value="PJN06093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN06093">
        <property type="protein sequence ID" value="PJN06093"/>
        <property type="gene ID" value="CG723_40810"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051607">
        <property type="term" value="P:defense response to virus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3210.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041372">
        <property type="entry name" value="Cas3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006483">
        <property type="entry name" value="CRISPR-assoc_Cas3_HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038257">
        <property type="entry name" value="CRISPR-assoc_Cas3_HD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18395">
        <property type="entry name" value="Cas3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18019">
        <property type="entry name" value="HD_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01596">
        <property type="entry name" value="cas3_HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51643">
        <property type="entry name" value="HD_CAS3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0051">Antiviral defense</keyword>
    <keyword evidence="8" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0540">Nuclease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HD Cas3-type" evidence="7">
        <location>
            <begin position="23"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="816"/>
            <end position="850"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PJN06093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="958" mass="104338" checksum="1F63F33F12D9AC76" modified="2018-04-25" version="1">MGVVEDSRSGGLPLCLWGKFSATLQLGYPVLFHMLDVAALAGELWDRFLTRQQRSLIAEGLGLTTAQARTVVMFWAGCHDLGKVSRFQECEPVGWARVSEELRADTGRWRLMRHERASMHAMVVILAQFGYPCTGNASPAVRAAQILGGHHGWFHQVDVHGAASPARVAAELGGALWQDVRFRYAAQIRHLTGASAVPTRVSVPAGVLIAGLVMVADQLASQPHAWMGRALAPKFGAAEHYACAVRPSLSSTGRSWADRVTSASGLERVDLPDAEFSTVHAPLTHPNALQQSVMQALEDAVARHGTGILIVTDRTGAGKTVVALEAQRIFTAHLGTRGVAILQPSTAIADAMYDTLTAYVAAHQPVRAPTTLVHSWLNAAYSNNALTRGSQITLDEYFTDTPDPNGRPAHRVTVPDGFLRGSDRALLAQFTVATLDQALMGVLPTRRNALRLLGLSGRTVVLDEAHAYSSYTLRLTERLLHWLGALGCPVVLLSATLPAAAAAALTRAYLAGAGHPSTALTERDLTPAYPGWLFAAGRDATVVRIDEATRIRHAKDQRSTPTVSLADVEHRPLADAARPVHRGERLALILSEAGRVAEEQGCVSIHTDTVTDAQDTYRYLQRELAGTGMRPGTDLVLLHARIAGHRREPLLRTLREGLGPRGHARPKRLIVVTTSLLEMSLNVDLDHVISDLAALHRLMHRLGRLWRFEQSWLNRSDRPQRPAWIQERGPHMTVLHPAHAGRTTLPDHRAPGDSDFLLHRTAELLRSKRTVTLPDDVPALIEQLHCPGEETGQAETLTALHDAHQATTRNDVWLADTQSVPPPNRVGSLSDLHRRPALPGQAPTRDGDRAKRLLPCHRHPGGRLTLDIHGQLDLPQGPRLKADEIRRLLNHVVSVPPAWVSGPPGQETPQPPTAWAEHPLLADLTLLVDDPRRPGPSTFGIHGLYMDHELGLVHTEDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JH13</accession>
    <name>A0A2M9JH13_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CG723_41335</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CB01635</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">In the C-terminal section; belongs to the transposase 35 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000036">
        <property type="protein sequence ID" value="PJN06047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN06047">
        <property type="protein sequence ID" value="PJN06047"/>
        <property type="gene ID" value="CG723_41335"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032196">
        <property type="term" value="P:transposition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001959">
        <property type="entry name" value="Transposase_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010095">
        <property type="entry name" value="Transposase_IS605_OrfB_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01385">
        <property type="entry name" value="OrfB_IS605"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07282">
        <property type="entry name" value="OrfB_Zn_ribbon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01766">
        <property type="entry name" value="tspaseT_teng_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0815">Transposition</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014993643" evidence="6">
        <location>
            <begin position="17"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="domain" description="OrfB_IS605" evidence="7">
        <location>
            <begin position="179"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="domain" description="OrfB_Zn_ribbon" evidence="8">
        <location>
            <begin position="301"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="218"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="230"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF07282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PJN06047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="387" mass="43036" checksum="0C13A91828DB6307" modified="2018-04-25" version="1">MKLVVRVKLLPTPVQAAALEATLYACNQAATWAAGVAFEENARRPLELRKHTYAEFRARWQLGAQAAQHAIKKTCDAYTTLKVNLRNGRYGRPGTKRHARASGKPVVFRPQAAQPYDDRMLSWQHEQQTVSIWSTAGRLKGVAFTGQAEQLEVLAAHRKGESDLVCQGGKWFLIATCDIDEATASTHPVGFLGVDLGIVNIAVTSDGARHCGRRINRKRESDRNLRSKLQKKNTKSAKRRAKKHAGKEARRAKDINHKISKRIVAEAERTGRGIALETLTGIRERARLRKPQRVKIHSWPFAQLGSFIAYKAKRAGVPVVYVDPAYTSQECAQCHHTARANRPSQAGRVCGFVEHADHNASHNIRQRGWMAWVCGAQSTAPELTLIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-06-02" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JH30</accession>
    <name>A0A2M9JH30_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">NUDIX hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CG723_40675</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CB01635</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the Nudix hydrolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000034">
        <property type="protein sequence ID" value="PJN06188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN06188">
        <property type="protein sequence ID" value="PJN06188"/>
        <property type="gene ID" value="CG723_40675"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020476">
        <property type="entry name" value="Nudix_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020084">
        <property type="entry name" value="NUDIX_hydrolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00502">
        <property type="entry name" value="NUDIXFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="SSF55811"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00893">
        <property type="entry name" value="NUDIX_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="4">
        <location>
            <begin position="1"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003476"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PJN06188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="130" mass="13805" checksum="EC487C123D23A209" modified="2018-04-25" version="1">MEPTIAGAVVGHEGEVLLVRRAVPEGDLVWQFPAGKVDPGETQEEAAVREALEEAGVVVEPLTIIGERLHPVTGRRVVYVACRWLSGAARAASPREVAEAAWVSMDGLAERIPGGVYGPVWEYLAGPALP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JH84</accession>
    <name>A0A2M9JH84_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_40180</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000033">
        <property type="protein sequence ID" value="PJN06240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN06240">
        <property type="protein sequence ID" value="PJN06240"/>
        <property type="gene ID" value="CG723_40180"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021530">
        <property type="entry name" value="DUF2877"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11392">
        <property type="entry name" value="DUF2877"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN06240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="314" mass="32252" checksum="E62D0188C279442A" modified="2018-04-25" version="1">MLHGRVERLRGAPGARGVTGTPAGGGSVRAGATRPEHVHLGTVSHVHLGTISTAVAPLLHGPFRPARVVAATRYAVHLATGDRELPALAVVTRDAIRLPNALVLPFSSADRPLDLNTPWAGVGAGRVIIGPVRLEPEASWTPPRVQDASSPPDPARIGQATVLLDALAQPLPPPLAPRLTDLRHALHADRSSEVRRAARALVGLGPGLTPSGDDILCGALLASRAWGGPLTPLSGAVADATLRTPLLSAALLRHAVRGECVPQAHAFLRALSGAVPLEPALRELLAVGHHSGGDLARGVLAVALSTARAATGDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JHC8</accession>
    <name>A0A2M9JHC8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Carbohydrate kinase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_39795</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000032">
        <property type="protein sequence ID" value="PJN06289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN06289">
        <property type="protein sequence ID" value="PJN06289"/>
        <property type="gene ID" value="CG723_39795"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011611">
        <property type="entry name" value="PfkB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00294">
        <property type="entry name" value="PfkB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="SSF53613"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PfkB" evidence="1">
        <location>
            <begin position="24"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN06289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="327" mass="34445" checksum="6D65ACA579394F50" modified="2018-04-25" version="1">MRTAVTGSIATDHLTVFPGRFADQLIPDQLEHVSLSFLVDSLDVRRGGVAANIAFGLGGLGLEPLLVGAVGADFAEYEVWLKENGVDTGGVHVSDERQTARFMCTTDRDSNQIASFYTGAMAEAREIDLTRLPVPVAGLDLVVVAPNDPEAMLRHTRQCRELGVAFAADPSQQLARLDGPQVRELVSGARWLFTNEYEAALLLERTGWSREEVLSRVGTWITTLGDRGALVESEGRPPLTVPAVAGVPVADPTGVGDAFRAGFLGAVARDLSLVTAARLGCALAARALATVGSQAYRVDKAALFDTVAQAYGTEAAQPLAGCLGGTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JHM5</accession>
    <name>A0A2M9JHM5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Dynein regulation protein LC7</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_39710</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000031">
        <property type="protein sequence ID" value="PJN06386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN06386">
        <property type="protein sequence ID" value="PJN06386"/>
        <property type="gene ID" value="CG723_39710"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004942">
        <property type="entry name" value="Roadblock/LAMTOR2_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03259">
        <property type="entry name" value="Robl_LC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00960">
        <property type="entry name" value="Robl_LC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Robl_LC7" evidence="1">
        <location>
            <begin position="8"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN06386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="132" mass="13815" checksum="EA488B241D36F955" modified="2018-04-25" version="1">MADNEGLGWLLDDLTERVEHVRHALVLSNDGLVTGASSDLRREDAEHLAAVSSGLHSLAKGSGRHFGAGGVRQTMIEFDDAVLFVTAAGDGSCLCVLSSAEADIGQVAYEMTLLVNRVGEHLGVGARRAEGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JIH5</accession>
    <name>A0A2M9JIH5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CG723_37975</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000027">
        <property type="protein sequence ID" value="PJN06668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN06668">
        <property type="protein sequence ID" value="PJN06668"/>
        <property type="gene ID" value="CG723_37975"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="25"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="57"/>
            <end position="64"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PJN06668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="335" mass="35032" checksum="27BBA205C4D8486A" modified="2018-04-25" version="1">MPPPGRPPTGRCTPLTRTGTVALVIEVSELTKRYGDKTAVDHLSFTVRPGQVTGFLGPNGAGKTTTMRMVLGLDAPTAGTSTVGGVPFRTHPRGLRHVGALLDAQQVHGGRSATAHLGALARSNRIPVSRVAEVLAEVGLTEAAGRRIGGFSLGMKQRLGIAAALLGDPPVLMFDEPINGMDPEGVLWVRGLFRHLAAEGRTVFLSSHLMTEMESTADQLVVIGQGRLIAAESVREFAARSTRFSVLVATPQAGELTAVLTAAGASVAPHGPPDAARIAVTGLPAERIGALAFEHRIMLHELTNRTASLEEAFMELTAGSVEYLSGNAGKAGQPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JIL1</accession>
    <name>A0A2M9JIL1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CG723_37900</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000027">
        <property type="protein sequence ID" value="PJN06708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN06708">
        <property type="protein sequence ID" value="PJN06708"/>
        <property type="gene ID" value="CG723_37900"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045232">
        <property type="entry name" value="FAM234"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013517">
        <property type="entry name" value="FG-GAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028994">
        <property type="entry name" value="Integrin_alpha_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_supfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21419">
        <property type="entry name" value="PTHR21419"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13517">
        <property type="entry name" value="FG-GAP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="SSF50998"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69318">
        <property type="entry name" value="SSF69318"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014902914" evidence="6">
        <location>
            <begin position="31"/>
            <end position="975"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="59"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PJN06708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="975" mass="102027" checksum="640CC07D6EDAFD20" modified="2018-04-25" version="1">MRHDSRRALRLASALVAAGLALSAAPPALAADDDGSSLLTLTDSQAEKLADHAQLNAYADADRETLDPQGATKGSGTSGKDDQGAGSHLDGTGTDGAVTISTKSTLEGVRGLAATVPAGDKGGDYFTLHSLGSVQRSKADGTALWRRDNASLYADWGVKNSRPWQTEPYPARVVMGYNAVSPFTPASDQGYVTGDLTGDGVDDVVFSASVGVAPYRPFTSPGSSLANGTFVTVLDGKTGKTLWSKLYAYAYNVKLVGKTLVVTDAPYYNLNSPADATATVSGIRFSYADGALKPTDTWTYDTGVRAGTAWGALEDLGGGLVAASYNQRRTATAAGRGRTLVLDTADGKVKWQSDSALYSRQLHLDTARGRLVALEQSDPNDGMKYEIDSYSLADGERTTLDTRINALPTDMTIGDLRGDRKPEYVVSESTLDPYLWINSNTVRVVDGTDPATLLWSSTVKRAADNGHDGPSAWSLDVVDGSLVTAAQDDTGMNSAENPGGGQYASLTVFSGSGDVRWREKGLGASPMFAQVYRDGGGQHVRTVDQNQNVHTYGFGNGKQQGVLPLQGDLSSSASADLDGDKKNDLVVGGKSDGVWAYSGPSLTAGKPKLLWKATVPGQVHRIEKGDVNGDGHDDFVVAADTAVAVIDGRNGKVIERIAGNGQFVRSVTVADLDGDKRADILVPTDALRAYRGNGSKLWTYAAPADAGGVVFGDPAVGEGRVYAQYTSGDSLENESPVVDGVALDAKKGTVRWTASPKAPAESVGGKLYGAVLSRGVFTSPKIPYADGHAVVYTWMGATSTTSSGAPDATSLTNIVEIRDSRTGEVLHQGIAGGAWTLGNYFTGPEGLILAGTASYRTYGAGGQDYSIYTLPTVETGGFLTGPGGRRLLVGGTDAGAYLWDPAVLTAGRHYPDGIGTITSLGAREYFSGDLDGDGVDELVNLGFDETGFDRTTELLGGRYLNQFTAISQLTVNTLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JIL7</accession>
    <name>A0A2M9JIL7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">AsnC family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CG723_37275</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000026">
        <property type="protein sequence ID" value="PJN06736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN06736">
        <property type="protein sequence ID" value="PJN06736"/>
        <property type="gene ID" value="CG723_37275"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000485">
        <property type="entry name" value="AsnC-type_HTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019888">
        <property type="entry name" value="Tscrpt_reg_AsnC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019887">
        <property type="entry name" value="Tscrpt_reg_AsnC/Lrp_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019885">
        <property type="entry name" value="Tscrpt_reg_HTH_AsnC-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01037">
        <property type="entry name" value="AsnC_trans_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13404">
        <property type="entry name" value="HTH_AsnC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00033">
        <property type="entry name" value="HTHASNC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00344">
        <property type="entry name" value="HTH_ASNC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00519">
        <property type="entry name" value="HTH_ASNC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50956">
        <property type="entry name" value="HTH_ASNC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH asnC-type" evidence="4">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PJN06736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="151" mass="16504" checksum="C6FD3349955E1590" modified="2018-04-25" version="1">MDAVDRQLIQALRENGRASYAELGRLVGLSGPSVTDRINRLEAAGVITGYRATVDSPSLGLGVTALIGISLSDAADHEDVAHRLKDLHEIEDCWFIAGDDSYMLKVRVGDVDGLERTIRRLSGTKGVSRTRTTIVLSTKWENRVGELPEEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JIN1</accession>
    <name>A0A2M9JIN1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_37240</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000026">
        <property type="protein sequence ID" value="PJN06729.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN06729">
        <property type="protein sequence ID" value="PJN06729"/>
        <property type="gene ID" value="CG723_37240"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019587">
        <property type="entry name" value="Polyketide_cyclase/dehydratase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10604">
        <property type="entry name" value="Polyketide_cyc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN06729.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="182" mass="20009" checksum="B46462EAABDE74A0" modified="2018-04-25" version="1">MTESSHPTEPAAPATPVAPGTSRTEGHTHSLHFTIPLPHPVEEVWAAVATPEGLPGWLAAADVLEPRLGGAVTLRWLNNGRAHQGRVTAWDGERVAEYTLEGPHGRLRFHLEPTAPDATTLRFTGEIDGDDSARLDYLAAWHDHFEHLAAALDGRPTDERAWAAWTPSRWQELRDGYLEAPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JIY8</accession>
    <name>A0A2M9JIY8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Branched-chain amino acid permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CG723_37335</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CB01635</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the AzlC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000026">
        <property type="protein sequence ID" value="PJN06747.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN06747">
        <property type="protein sequence ID" value="PJN06747"/>
        <property type="gene ID" value="CG723_37335"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011606">
        <property type="entry name" value="Brnchd-chn_aa_trnsp_permease"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34979">
        <property type="entry name" value="PTHR34979"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03591">
        <property type="entry name" value="AzlC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="39"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="151"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="184"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="214"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="246"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="247"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010735"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PJN06747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="278" mass="27780" checksum="153E49F4CD1CF9CD" modified="2018-04-25" version="1">MRSPHRTDGPLERTAEDRAAPSDPAAAPAHSDRRLLRDIALVCLADAVVGVSFGAIAVTGGLPVWVPVLMSLIVFAGSAQFSTVAVLAAGGGPVAAAATGLLLNTRTAAFSLAVADALGRSWPARLVGAHLVTDETAAFVLAQRDPRRRRAAFWISGLGLFAAWNLSVLAGALAGSALGDTARFGLDAAFPAVLLALVLPALRGGAGVRRAAAAGAVIAVAATPVLPAGMPVLLALTGLLVARTPRRGSPSLTTGRGSSSPTTGPEAPTRTTSPGASS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JJ31</accession>
    <name>A0A2M9JJ31_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CG723_37040</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CB01635</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LytR/CpsA/Psr (LCP) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000025">
        <property type="protein sequence ID" value="PJN06885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN06885">
        <property type="protein sequence ID" value="PJN06885"/>
        <property type="gene ID" value="CG723_37040"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004474">
        <property type="entry name" value="LytR_CpsA_psr"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03816">
        <property type="entry name" value="LytR_cpsA_psr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00350">
        <property type="entry name" value="lytR_cpsA_psr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="117"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="domain" description="LytR_cpsA_psr" evidence="4">
        <location>
            <begin position="190"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF03816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PJN06885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="433" mass="46519" checksum="BD5573A8A3B7EF83" modified="2018-04-25" version="1">MNDWPEGWGDSQGGGDRGYGRGSSSARPEGARAMPHVQRGQGGGSRRSAPPRPTVPAQPSYGEGYGDQYDSGYNTGQVYGGGGGRRGGSGYVPNDNDPADGYAPPRARPDWRRRIKWAVLTLVVVFLGVSIGTYFWADSKLHRDVDLSKVIERPETGKGTNYLIVGTDSRAGMSDEEKKKLHTGSAEGKRTDTMMILHTGDNGSTMISLPRDSNVTVPSYKGSDSGKLYPNQGRQVKLNAAYAEDGPELLVRTVEFNTGLHIDHYAEIGFGGFAKIVDAVGGVEMNLKEGFKDKWSGADFQKGKQTLNGQQALAFVRTRHAFAASDLQRTKNQQAFLSALAHQVATPSTVLNPFKLYPTMGAGLDSLVVDKDMSLWDLGSMFFAMKGVTGGDGKSMNMPVSGSVNGNLVWDKTKVKQLVGELKDDAPVTVSGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JJ35</accession>
    <name>A0A2M9JJ35_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glyoxalase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_37020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000025">
        <property type="protein sequence ID" value="PJN06881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN06881">
        <property type="protein sequence ID" value="PJN06881"/>
        <property type="gene ID" value="CG723_37020"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041581">
        <property type="entry name" value="Glyoxalase_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18029">
        <property type="entry name" value="Glyoxalase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VOC" evidence="1">
        <location>
            <begin position="5"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN06881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="120" mass="12824" checksum="76F8CB94256407D6" modified="2018-04-25" version="1">MALATLGVVVLDCPDPRALADFYAEVLGGTVTSDDGTWVDLEVPGGRPLAFQAAPDFVAPSWPAPDRPQQFHLDLTVEDLDTAEKGVLALGAKVLDAEDRSRTWRVYADPAGHPFCLCAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JJB8</accession>
    <name>A0A2M9JJB8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_36345</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000024">
        <property type="protein sequence ID" value="PJN06964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN06964">
        <property type="protein sequence ID" value="PJN06964"/>
        <property type="gene ID" value="CG723_36345"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN06964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="245" mass="25564" checksum="8EAD92ADCC0FC315" modified="2018-04-25" version="1">MSGITGKVVAITGASSGIGEATALLLAERGARLVLGARRSERLEKLVARIEKAGGEAVQIRTDVTRLDDVRALVGLAGERFGRLDVLISNAGVGTISPLDDLRTAEWDHMVDVNIKGVLHGIGAALPVFRAQGGGHFVTTASTAAFRVAPAMAVYAGTKIAVRAICEGLRQEAGPTVRVSTVSPGVIDTDFPEASTNERVRAEIAGMRDRVAIPPSAIARAIAFAIEQPADVDVNEIVVRPTAQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JJD6</accession>
    <name>A0A2M9JJD6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Gluconolaconase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_36560</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000024">
        <property type="protein sequence ID" value="PJN06996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN06996">
        <property type="protein sequence ID" value="PJN06996"/>
        <property type="gene ID" value="CG723_36560"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013658">
        <property type="entry name" value="SGL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005511">
        <property type="entry name" value="SMP-30"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08450">
        <property type="entry name" value="SGL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01790">
        <property type="entry name" value="SMP30FAMILY"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SGL" evidence="1">
        <location>
            <begin position="14"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN06996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="291" mass="30420" checksum="A7B31696A1B4AEA0" modified="2018-04-25" version="1">MVTPSPVGTERLELGEGVRWTERGLVLTDILTGRLLSADLTGATLREELRLPFPLGAVAPVAGAPHTWIAAADTGICLLQAGESPRWLLRPEQDPAVPFRMNDAAADPSGRFWAGFMAYDAAPGRGGLFRVDRDGTVTQALDGLSVPNGPAFTADGRTMYLADSPLGRILRHRVDAETGDVDEGEVFAAVESGSPDGMAVDQDGGLWSAVWGAGVLHHYRADGRLDEVVPVPVRQPAGMCLGGADGRTLFVTSAHIGLDEPGPLDGALLRLRVAVPGTSACAFRPGSGLVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JJW7</accession>
    <name>A0A2M9JJW7_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Lipid II isoglutaminyl synthase (glutamine-hydrolyzing) subunit MurT</fullName>
            <ecNumber evidence="1">6.3.5.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">murT</name>
        <name evidence="4" type="ORF">CG723_34720</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CB01635</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">The lipid II isoglutaminyl synthase complex catalyzes the formation of alpha-D-isoglutamine in the cell wall lipid II stem peptide. The MurT subunit catalyzes the ATP-dependent amidation of D-glutamate residue of lipid II, converting it to an isoglutamine residue.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + beta-D-GlcNAc-(1-&gt;4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate + H2O + L-glutamine = ADP + beta-D-GlcNAc-(1-&gt;4)-Mur2Ac(oyl-L-Ala-D-isoglutaminyl-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate + H(+) + L-glutamate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:57928"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:60033"/>
            <dbReference type="ChEBI" id="CHEBI:62233"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.5.13"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + beta-D-GlcNAc-(1-&gt;4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate = ADP + beta-D-GlcNAc-(1-&gt;4)-Mur2Ac(oyl-L-Ala-gamma-D-O-P-Glu-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate</text>
            <dbReference type="Rhea" id="RHEA:59488"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:60033"/>
            <dbReference type="ChEBI" id="CHEBI:143132"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>beta-D-GlcNAc-(1-&gt;4)-Mur2Ac(oyl-L-Ala-gamma-D-O-P-Glu-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate + NH4(+) = beta-D-GlcNAc-(1-&gt;4)-Mur2Ac(oyl-L-Ala-D-isoglutaminyl-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:57932"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:62233"/>
            <dbReference type="ChEBI" id="CHEBI:143132"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Forms a heterodimer with GatD.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the MurCDEF family. MurT subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.13" evidence="1"/>
    <dbReference type="EMBL" id="NNBL01000022">
        <property type="protein sequence ID" value="PJN07152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN07152">
        <property type="protein sequence ID" value="PJN07152"/>
        <property type="gene ID" value="CG723_34720"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140282">
        <property type="term" value="F:carbon-nitrogen ligase activity on lipid II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02214">
        <property type="entry name" value="Lipid_II_synth_MurT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043703">
        <property type="entry name" value="Lipid_II_synth_MurT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036565">
        <property type="entry name" value="Mur-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013221">
        <property type="entry name" value="Mur_ligase_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013564">
        <property type="entry name" value="MurT_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08245">
        <property type="entry name" value="Mur_ligase_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08353">
        <property type="entry name" value="MurT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53623">
        <property type="entry name" value="SSF53623"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0133">Cell shape</keyword>
    <keyword evidence="1" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="1 4" id="KW-0436">Ligase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="1" id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Mur_ligase_M" evidence="2">
        <location>
            <begin position="65"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="domain" description="MurT_C" evidence="3">
        <location>
            <begin position="304"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="338"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="201"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="204"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="217"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="220"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08353"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PJN07152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="412" mass="43618" checksum="E493295B26109328" modified="2018-04-25" version="1">MSGNSEPLTPRAKLAVTAGKAAAAVSRAAGRGSGSVIGGKVALRLDPELLGRLAQHLDVVLVSATNGKTTTTRLIAEALRAAGPVVSNALGANMPAGITSALAGGSDAKFGVIEVDEKYLAGVARDTAPKAIALLNLSRDQLDRAAETRMLAEKWREGLAGSKAIVIANADDPLVVWAASSSPNVVWVAAGQEWKDDAWSCPSCGGVMQRPGDDWYCGECGFRRPTPSWALQGDYVLDPHGSAWPIHLQLPGRANKANATSSAAVAACFGVPPQVALERMYQVQAVAGRYDVVQFLGRDLRLLLAKNPAGWLETFSLIDPPPTPVILSVNARGADGTDTSWLWDVDYTRLAGHPIFVIGDRRLDLAVRLEVAGLDFRVCESVDEAVQSAPPGRIELIANYTAFQDVRRRVGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JK40</accession>
    <name>A0A2M9JK40_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_35180</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000022">
        <property type="protein sequence ID" value="PJN07234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN07234">
        <property type="protein sequence ID" value="PJN07234"/>
        <property type="gene ID" value="CG723_35180"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014773739" evidence="2">
        <location>
            <begin position="21"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="27"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="74"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN07234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="155" mass="16052" checksum="871941E4595A8A49" modified="2018-04-25" version="1">MHRSTTSAALLLTVAATAAAVSGCVSVRQPEPPAVSPSPPAAPAAPRPDGRAEPQVVQAPAREALDRMGRTPPAHSPSPEPTRAPRPPQPPRQEAPRRSGPDHAARPAAPAPRHPHTAAPAAPGVPGDVCALGNQYGKWNPDSPEARICRETYGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JKQ6</accession>
    <name>A0A2M9JKQ6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Deacylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_33705</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000020">
        <property type="protein sequence ID" value="PJN07454.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN07454">
        <property type="protein sequence ID" value="PJN07454"/>
        <property type="gene ID" value="CG723_33705"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036264">
        <property type="entry name" value="Bact_exopeptidase_dim_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011650">
        <property type="entry name" value="Peptidase_M20_dimer"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07687">
        <property type="entry name" value="M20_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55031">
        <property type="entry name" value="SSF55031"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="M20_dimer" evidence="1">
        <location>
            <begin position="217"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN07454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="451" mass="48561" checksum="D219110324070E54" modified="2018-04-25" version="1">MSAQELDGLDERRRAWTEEAWGHVTAERLRELIVGLVGVASPTGDERPLAEHIAASLAGVGLRATAQPIDDRQANAWARLEGDGTGPDLMLYAPIDTLTVGEESEDVPWIGPQLREDMQPRATVYDDLVTGLGASNPKGHAACVMMAAEAIALAGIPLTGDLVAAFGAGGMPTNARPGSARANTGQGVGCSFLLEQGVWTDYAVIAKPGWTVSWDEVGLAWFEVTVHGTHTYVGSRHRLPYDNAIVRAGDVVRHLEEWFVEYAERHTDGTVAPQGIVSSVRGGWPRMAAVTPAACTLRVDLRISPDTTPMQAKREFAAAVGELKRKLPGLDATVEMILAIPGTATSRESWIYRSAAGAWEAFEGRPHEPIRGNSGATDANILRGRGIPTVRVGMPKVSGEQAPFDIDFARGMNTVSVREMERLTRHLIRTAVDTVTRSREELEPELEGARA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JL07</accession>
    <name>A0A2M9JL07_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CG723_32850</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CB01635</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000019">
        <property type="protein sequence ID" value="PJN07560.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN07560">
        <property type="protein sequence ID" value="PJN07560"/>
        <property type="gene ID" value="CG723_32850"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032688">
        <property type="entry name" value="ABC2_membrane_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12679">
        <property type="entry name" value="ABC2_membrane_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="52"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="95"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="128"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="158"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="206"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PJN07560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="239" mass="24770" checksum="8E4661AEF598E08E" modified="2018-04-25" version="1">MYDPTVARLTYRALLGRRRALILCALPVLLIAISALVRGLTGADDQIAADVLGGFALATMVPIIGVIAGTGAIGPEIDDGSVVYLLAKPIKRPTIIFTKLIVAIAVTMVFSAVPTLIAGLILNGNGQQIAVAYTIAALVASIAYAALFLLLGTITRHAVVFGLVYALVWEALFGSLVAGARTLSVQQWSLAVAHKVAGGDLITSDVGLPLATVLLAGVTVLATWYAGQKLRTLKLAGEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JL58</accession>
    <name>A0A2M9JL58_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Peptidoglycan glycosyltransferase</fullName>
            <ecNumber evidence="1">2.4.1.129</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CG723_33095</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">CB01635</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>[GlcNAc-(1-&gt;4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)](n)-di-trans,octa-cis-undecaprenyl diphosphate + beta-D-GlcNAc-(1-&gt;4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate = [GlcNAc-(1-&gt;4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)](n+1)-di-trans-octa-cis-undecaprenyl diphosphate + di-trans,octa-cis-undecaprenyl diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23708"/>
            <dbReference type="Rhea" id="RHEA-COMP:9602"/>
            <dbReference type="Rhea" id="RHEA-COMP:9603"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58405"/>
            <dbReference type="ChEBI" id="CHEBI:60033"/>
            <dbReference type="ChEBI" id="CHEBI:78435"/>
            <dbReference type="EC" id="2.4.1.129"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.129" evidence="1"/>
    <dbReference type="EMBL" id="NNBL01000019">
        <property type="protein sequence ID" value="PJN07603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN07603">
        <property type="protein sequence ID" value="PJN07603"/>
        <property type="gene ID" value="CG723_33095"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004180">
        <property type="term" value="F:carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008658">
        <property type="term" value="F:penicillin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008955">
        <property type="term" value="F:peptidoglycan glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3810.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001264">
        <property type="entry name" value="Glyco_trans_51"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023346">
        <property type="entry name" value="Lysozyme-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036950">
        <property type="entry name" value="PBP_transglycosylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001460">
        <property type="entry name" value="PCN-bd_Tpept"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00912">
        <property type="entry name" value="Transgly"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00905">
        <property type="entry name" value="Transpeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53955">
        <property type="entry name" value="SSF53955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="145"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="domain" description="Transgly" evidence="11">
        <location>
            <begin position="194"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="domain" description="Transpeptidase" evidence="10">
        <location>
            <begin position="579"/>
            <end position="763"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="533"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="815"/>
            <end position="916"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="44"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="821"/>
            <end position="906"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PJN07603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="916" mass="97049" checksum="9B806BB47D95AEF1" modified="2018-04-25" version="1">MSEHRRKPPQPQGGGRAAARRGTSGASPGRRAAPRDATGSPSDAYGAPGSTGSSGSTGDDRPYGGRAEARRAAQRSAGGSRRKAPDGSGGRGGGGRRGGGGPEGAGGPGRGRGRGPSRPPQKKRFIDYPRSDKYGVHRWLPSWRLVMGLFVGFCGSLMAAAGIGYALVDVPKTADTAKAQNNVYYWANGKQMVATGGETNRQIIKYEEIPEAMRYAVMSAENKTFESDKGVDPMGIARAFVNMAKGGQTQGGSTITQQYVKNAMLDDQSQTISRKVKELFVSIKVGRTEPKEKVMAGYLNTAYYGRGAYGIQAAARTYFDEEAQKLNASQCAFLASVLKGATYYDPAGAPEIDPVEATPAKNSARAEKRWRWILDEEVKDGRLSAAKRHDFSKFPRLQNPRSNAQLGGQVGYLVDLAKAYVINNSDGRITALDLQKGGYEIHTTFDKTKVDKLEAAVKKVRKENIKAKLRPKTDRYVQFGGASVNPTSGAIEAIYGGEDATTHYTNNADQTGAQVGSTFKPFVLAAAMRDGVRDPKGLEDQGDEQRTPVSPKSLYSGQNKLKIKKYNGEVWTDKDGKEWLQTNDGGASYNRPTFQIDLREAMRESVNSAYVQLGMDVGLDKVKQAAKDAGIKDNSFASANYPSFSLGTSDPSAIRMAGAYGTFAASGQRNDPFSVTSVDHAGETVYQHEKAPVRAFQPAVADNVTDVLRTVVDKGTGTNAKLPDRQVAGKTGTTDGNKSAWFVGYTPQLSTAITMYRMDDNENSKKREFLEMYGTGGQEKIHGASFPSEIWHDYMMEALKGAPVKVFPTPEPIGEIVGATPSPSITPSATPSPSDSATVEPSPSQSSPGPSPSTSESCSSWSWNCNDNGGTSNGGTGGTPTGGTDGGVTSSPSDPGGGNGGSNGNGNGGIFGGPAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JLG3</accession>
    <name>A0A2M9JLG3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA polymerase III subunit epsilon</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_31980</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000018">
        <property type="protein sequence ID" value="PJN07698.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN07698">
        <property type="protein sequence ID" value="PJN07698"/>
        <property type="gene ID" value="CG723_31980"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004527">
        <property type="term" value="F:exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013520">
        <property type="entry name" value="Exonuclease_RNaseT/DNA_pol3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00929">
        <property type="entry name" value="RNase_T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00479">
        <property type="entry name" value="EXOIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Exonuclease" evidence="1">
        <location>
            <begin position="8"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN07698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="241" mass="26632" checksum="F4680BF43BFD0977" modified="2018-04-25" version="1">MTCWYEGPLAAFDTETTGVDVESDRIVSAAIVVQDAAGSRPRVSRWLVNPGVPVPAGATEVHGLTDEHLQRNGRWPAPVMEEIARLLGEQAAAGRPLVVMNAPFDLTLLDRELRRHRASALGRYMESSSLCVLDPRVLDKHLDRYRKGRRTLTDLCAQYEVELEGAHDAAADAQASLDVVRAVGRRFASRLERLSPAELHTLQAVWHAAQARGLQAWFARSGNPETVDPAWPMRTELREAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JLH9</accession>
    <name>A0A2M9JLH9_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Beta sliding clamp</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CG723_33215</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">CB01635</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of replication as well as for processivity of DNA replication.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Forms a ring-shaped head-to-tail homodimer around DNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the beta sliding clamp family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000019">
        <property type="protein sequence ID" value="PJN07627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN07627">
        <property type="protein sequence ID" value="PJN07627"/>
        <property type="gene ID" value="CG723_33215"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009360">
        <property type="term" value="C:DNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008408">
        <property type="term" value="F:3'-5' exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00140">
        <property type="entry name" value="beta_clamp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001001">
        <property type="entry name" value="DNA_polIII_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022635">
        <property type="entry name" value="DNA_polIII_beta_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022637">
        <property type="entry name" value="DNA_polIII_beta_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022634">
        <property type="entry name" value="DNA_polIII_beta_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30478">
        <property type="entry name" value="PTHR30478"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00712">
        <property type="entry name" value="DNA_pol3_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02767">
        <property type="entry name" value="DNA_pol3_beta_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02768">
        <property type="entry name" value="DNA_pol3_beta_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000804">
        <property type="entry name" value="DNA_pol_III_b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00480">
        <property type="entry name" value="POL3Bc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00663">
        <property type="entry name" value="dnan"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 9" id="KW-0235">DNA replication</keyword>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7 9" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="5 9" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DNA_pol3_beta" evidence="10">
        <location>
            <begin position="1"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="domain" description="DNA_pol3_beta_2" evidence="11">
        <location>
            <begin position="127"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="domain" description="DNA_pol3_beta_3" evidence="12">
        <location>
            <begin position="249"/>
            <end position="373"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR000804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF02767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF02768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PJN07627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="376" mass="39721" checksum="A149CD25FDA8C9FD" modified="2018-04-25" version="1">MKIRVERDVLAEAVAWAARSLPARPPAPVLAGLLLKAEEGALSLSSFDYEVSARVSVDAEIDEEGTVLVSGRLLADICRALPNRPVEISTDGVRATVVCGSSRFTLHTLPVEEYPALPQMPTATGTVPGEVFASAAAQVAIAAGRDDTLPVLTGVRIEIEGDTVTLASTDRYRFAVREFLWKPEDPEASAVALVPAKTLLDTAKALTSGDTVTLALSGSGAGEGLIGFEGAGRRTTTRLLEGDLPKYRTLFPTEFNSVAVIETAPFVEAVKRVALVAERNTPVRLSFEQGVLILEAGSSDDAQAVERVDAQLEGDDISIAFNPTFLLDGLSAIDSPVAQLSFTTSTKPALLSGRPAVDAEADDAYKYLIMPVRLSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JLI4</accession>
    <name>A0A2M9JLI4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">TetR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_32175</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000018">
        <property type="protein sequence ID" value="PJN07729.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN07729">
        <property type="protein sequence ID" value="PJN07729"/>
        <property type="gene ID" value="CG723_32175"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="8"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="29"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN07729.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="189" mass="20787" checksum="6F141D2AC2551082" modified="2018-04-25" version="1">MDYPRLMSVDREQVLRTAAALLTRKATATMDEVARAAGLSRATLHRHFAGRDTLVRALEELGIQECEAALDAARLDEGGADDAVRRLVTEIQPCAGLLAFLVTENQLFEGESQNEGWARLDARIAALFTRGQERGEFRIDLTPAWLTEALYSLIGGGAWAVQDGRVAAKDFQHMIVELLLGGARRRVEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JLI5</accession>
    <name>A0A2M9JLI5_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF4132 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_32200</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000018">
        <property type="protein sequence ID" value="PJN07734.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN07734">
        <property type="protein sequence ID" value="PJN07734"/>
        <property type="gene ID" value="CG723_32200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025406">
        <property type="entry name" value="DUF4132"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13569">
        <property type="entry name" value="DUF4132"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4132" evidence="1">
        <location>
            <begin position="26"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN07734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="285" mass="31284" checksum="FEC11EC3278E4F06" modified="2018-04-25" version="1">MGWMRAGDYEVALDDGGKVVCRNGKGRLLKSVPPKIADEQAVIGLRQLTEWLERHERDCRERAERWMTRSLPVPAAVLAEVWPDPAWRAALKDLVVTGDDGEVAGFLRDADPERGIGLVDLDGDTVRIRPRQISIPHPVLLDDLGELREFAVELGVDQGVQQLFREIWTRGAGRDPAAQAVDDYEGGTFKELRFLAGRATSLGYRVRGGHAVQPVLEAGRTVEARVWIGDYEGYAETETGPLTWTTEAGQAIALGEVGPVAWSEGMRMAAALYAGRELEDGEQVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JLT3</accession>
    <name>A0A2M9JLT3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Short-chain dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_31090</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000017">
        <property type="protein sequence ID" value="PJN07851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN07851">
        <property type="protein sequence ID" value="PJN07851"/>
        <property type="gene ID" value="CG723_31090"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="42"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN07851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="322" mass="34443" checksum="E231284A0328819A" modified="2018-04-25" version="1">MVRHRPAGRRRRRGARRPRAARAAYGGGTGRAAHRRPVQRFAGRIRRPDPLRRNPRHGAWDRRRTVSTPERKKPRIALVTGAAGGIGAAIARRLSKEGVKVVLADLRADRLAPLVAENTGPFAALEVDLTDRASLPDFVDRAWEVFGGLDILVNAAGLYPSAPLLEMRDDQWDQVMDVNLSAVFSLSRAFARRVVDAGTGGHIVNISSGASARARRGAAHYCTSKAGLDMLTKAFALELAEHRIHVNAVSPGFIEVDSEVNPLGADYVRSIRGGQPWPRAGVPEDIAAAVAYLCGPDAEWITGASLSVDGGAGTGNAALPLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JM44</accession>
    <name>A0A2M9JM44_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">M20_dimer domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_31085</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000017">
        <property type="protein sequence ID" value="PJN07944.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN07944">
        <property type="protein sequence ID" value="PJN07944"/>
        <property type="gene ID" value="CG723_31085"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017439">
        <property type="entry name" value="Amidohydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036264">
        <property type="entry name" value="Bact_exopeptidase_dim_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002933">
        <property type="entry name" value="Peptidase_M20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011650">
        <property type="entry name" value="Peptidase_M20_dimer"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07687">
        <property type="entry name" value="M20_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01546">
        <property type="entry name" value="Peptidase_M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55031">
        <property type="entry name" value="SSF55031"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01891">
        <property type="entry name" value="amidohydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="M20_dimer" evidence="2">
        <location>
            <begin position="246"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN07944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="507" mass="53199" checksum="F23B927C8E020ECE" modified="2018-04-25" version="1">MRPGNRRRAGHPADPGGVPGRPRPSPGPVGEEVRPGRRGDCRVTASVPGPVPAAQLKERARAAIEACRERLLDLSEDLQRHPETGFREHRSAATVAGWFTELGLPFESGLSLTGVKAHMSGRTPGPTVAVLGELDALVLPRHPLADPETGAAHACGHHAQVASMIGAAVGLAAVRRHLEGDVAFLAVPAEESVELEWRRERVRAGELKHLVGKADLLARGAFDDVDMAMLCHTSGQPARLSVGDSHNGSVVKRIVFTGRASHAGSSPWHGVNALKAATLAISAIDAQRDTFRDEDAVRVNAVLLHGGDAPTAVPDRAELEVVIRARTLDALRGACAAVDRAARAGTVALGAGATVETTLNYLPHHQDPALVALARTNGTALFGPDSVAPGRHLGASTDMGDLGAVMPVLHPFTAGATGDAHSVDYAVTDHVLAALEPAVLMAWCVIDLLVDGAAGAHDVLARRERRTAAEPDERPTADRYSDLRAGFDGLTHYDGTHDTVRGTEGEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JM57</accession>
    <name>A0A2M9JM57_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CG723_31635</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CB01635</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">In the C-terminal section; belongs to the transposase 35 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000017">
        <property type="protein sequence ID" value="PJN07955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN07955">
        <property type="protein sequence ID" value="PJN07955"/>
        <property type="gene ID" value="CG723_31635"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032196">
        <property type="term" value="P:transposition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001959">
        <property type="entry name" value="Transposase_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010095">
        <property type="entry name" value="Transposase_IS605_OrfB_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01385">
        <property type="entry name" value="OrfB_IS605"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07282">
        <property type="entry name" value="OrfB_Zn_ribbon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01766">
        <property type="entry name" value="tspaseT_teng_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0815">Transposition</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014948607" evidence="6">
        <location>
            <begin position="19"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="domain" description="OrfB_IS605" evidence="7">
        <location>
            <begin position="177"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="domain" description="OrfB_Zn_ribbon" evidence="8">
        <location>
            <begin position="301"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="378"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="383"/>
            <end position="406"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF07282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PJN07955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="412" mass="45927" checksum="8B33787F591B25A3" modified="2018-04-25" version="1">MKLTVQVKLLPTPVQASALEETLHACNEAATWVSSVAFEKDIKSNFALREHTYTQVKDRWGLGAQAAQHVIKKTCDAYRTLRANLTAGNLGKPSSKRFRRAVEKPIAFRLEGAQPYDDRMLSWQYTGRTVSIWTLSGRMKEVAFTAAPEHLARLALCRKGESDLLFRDGMWFLTATCEVPEAELTTGVTEFLGVDLGIVNIATTSDGQIMAGRRLNRGRLRERTLRTKLQRKNTPSVKRRLKNRRRKEARRARDINHKIAKHVVAEAERTGRGIALEVLTGIRARVRLRKPQRATHSSWAFAQLADFIAYKARRAGVPVVHVDPAYTSRTCAECGHIDKANRASQARFVCRSCGVVAHADWNGSRNIRHRAEELWRCGAQSTAPDPPPNTGRGTGRKRSTTASGARCASPGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JML2</accession>
    <name>A0A2M9JML2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Dienelactone hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_30580</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000016">
        <property type="protein sequence ID" value="PJN08106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08106">
        <property type="protein sequence ID" value="PJN08106"/>
        <property type="gene ID" value="CG723_30580"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002925">
        <property type="entry name" value="Dienelactn_hydro"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01738">
        <property type="entry name" value="DLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DLH" evidence="1">
        <location>
            <begin position="16"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN08106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="248" mass="26600" checksum="E94B68BF22E9578E" modified="2018-04-25" version="1">MPTKTLQIPTADGQADAFAAFPNDGAPHPGVLLYSDAFGLRPELVDKARELAGHGYYALVPNLYYRHGPAPVVELPEYIGEEVRPAVIAQLMPVLEAHTTEHARRDADAYLRFLTTQPEVSAGPVAVIGYCIGTLFAMRTAAAHPDQVAAVAGFHPGFVVTDTPDSPHRLIPELTAEVHLGLADDLPSEAISELNEALDAAGLGHTIEIYPGTVHGFTMSDTEAFNASGLQRHWDRLLPLLARTLGKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JMP9</accession>
    <name>A0A2M9JMP9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF397 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_29475</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000015">
        <property type="protein sequence ID" value="PJN08138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08138">
        <property type="protein sequence ID" value="PJN08138"/>
        <property type="gene ID" value="CG723_29475"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007278">
        <property type="entry name" value="DUF397"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04149">
        <property type="entry name" value="DUF397"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF397" evidence="1">
        <location>
            <begin position="8"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN08138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="62" mass="6739" checksum="BFD9E08DDE3806EF" modified="2018-04-25" version="1">MSTTEDLSWFKSSYSGGEGDNCIEIAVRPDAVNVRDSKDTGRRPFTVTPDAWSAFTTYASGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JNC8</accession>
    <name>A0A2M9JNC8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">AAA family ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_28730</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000014">
        <property type="protein sequence ID" value="PJN08372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08372">
        <property type="protein sequence ID" value="PJN08372"/>
        <property type="gene ID" value="CG723_28730"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011704">
        <property type="entry name" value="ATPase_dyneun-rel_AAA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07728">
        <property type="entry name" value="AAA_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA" evidence="2">
        <location>
            <begin position="96"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="159"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN08372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="372" mass="39889" checksum="68986BAA404C2490" modified="2018-04-25" version="1">MADRDPHVPAQADGAAADPGAWRIYRGTARPRGKDPVSRELPPPPPWRRFTGAPLISGPPPGDEDEFTRRLGPPDGAVVRKASEQELDLVNAALFLRRPLIVAGPPGIGKSSLAHCISRELSLGRVLRWSITSRSTLKEGLYAYDAIGRVQEAATRGALRGAEPGSDPGDPAPDPDGLNNLGDYVQLGPLGTALLPREIPRVLLIDEFDKSDTDLAGDLLSVFEEGEFRIPELARVRSRLPDAEVHTDDPDGTAVIHHGAVRCAAFPVVVITSNGERTLPPALLRRCLYLDLPAPDAGQLAAMLAAQLSQDDEGRTAMIRDFLNHARTGGSLAADQLLNSEFLRTTPAGPDQGSMSTLLHALWRRLDEVGTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JNF2</accession>
    <name>A0A2M9JNF2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Undecaprenyl-phosphate alpha-N-acetylglucosaminyl 1-phosphate transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CG723_28825</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CB01635</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000014">
        <property type="protein sequence ID" value="PJN08390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08390">
        <property type="protein sequence ID" value="PJN08390"/>
        <property type="gene ID" value="CG723_28825"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008963">
        <property type="term" value="F:phospho-N-acetylmuramoyl-pentapeptide-transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000715">
        <property type="entry name" value="Glycosyl_transferase_4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22926">
        <property type="entry name" value="PTHR22926"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00953">
        <property type="entry name" value="Glycos_transf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="46"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="74"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="102"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="151"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="196"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="221"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="274"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="300"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PJN08390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="343" mass="34149" checksum="6FCE7977A3A59D05" modified="2018-04-25" version="1">MSYGIAAAATALLAASALTALLRLVALRTGFTVRRVGRAGRRTPRLGGAAVATVTAVVATVGACTGLLPLGSGALTLLIAAGAVAALGFLDDLRPVGARARVVVEAGAATFVVHTAQLGFLVGALAVLWIVFVTNACRLFDTSDGALGTVAVVAALGLSACATTQGLGPLAATLGVLAAALTGFLMHNWYPARMHLGSCGSLFTGFLLASAAVLVNAGHEALPGAGSLFAVTVVVTADAALVAVSRRRAGRPLFQGGADHIAHRLRLLGLTPRGVAVVLGVASLAGAVTGLLLHDGTLDPLAALLPLCAAAGSVAGLLRVPVYGLRRRVHRPVRTAVVDVAGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JNR3</accession>
    <name>A0A2M9JNR3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_27400</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000013">
        <property type="protein sequence ID" value="PJN08511.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08511">
        <property type="protein sequence ID" value="PJN08511"/>
        <property type="gene ID" value="CG723_27400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012545">
        <property type="entry name" value="DUF1697"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36439">
        <property type="entry name" value="PTHR36439"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08002">
        <property type="entry name" value="DUF1697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF008502">
        <property type="entry name" value="UCP008502"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN08511.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="216" mass="23161" checksum="AAE9D158B65D10D2" modified="2018-04-25" version="1">MAPGSGRARRGNEEGTRTHMRTVPSDATDVTAPAGQTDPTYIAFLRAVNVPGRKVEMARLREVLTQLGFTGARTYIASGNAFFTGAGNDRARIVERVEAGLAETFGFEVPTILRTTDELRTELAASPFVGRQPAPDERFSMVYSSGPLTDGGFPLRSAKGDWEVLGACGATAYVRWRLVNGRPVNPVPAIEKTFGVQATGRFFHTSEKILAAAGKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JNX5</accession>
    <name>A0A2M9JNX5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Non-ribosomal peptide synthetase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CG723_27600</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CB01635</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Antibiotic biosynthesis.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000013">
        <property type="protein sequence ID" value="PJN08545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08545">
        <property type="protein sequence ID" value="PJN08545"/>
        <property type="gene ID" value="CG723_27600"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00148">
        <property type="reaction ID" value="UER00238"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043604">
        <property type="term" value="P:amide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008610">
        <property type="term" value="P:lipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901566">
        <property type="term" value="P:organonitrogen compound biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010071">
        <property type="entry name" value="AA_adenyl_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001242">
        <property type="entry name" value="Condensatn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00668">
        <property type="entry name" value="Condensation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="SSF47336"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01733">
        <property type="entry name" value="AA-adenyl-dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="3">
        <location>
            <begin position="1029"/>
            <end position="1104"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="2">
        <location>
            <position position="1064"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PJN08545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="1135" mass="121251" checksum="A88680419BEBAAFE" modified="2018-04-25" version="1">MTETLPADTSALQRAVAELSPERRALLARHLARGRAGSGISVTALPRTGEAQRYVASPGQQQLYYQYQLDPSAVNYLLPIAVRLRGDLDTQALERALAAVVARHEALRTRFATDPEHGVVQVVGTPDEVRVALGRGRARADEVPALLDRIARRPFDLSAAPLLRANLWQLTDDPEAPDGRTWLLTLCVHHIVVDGWSLGVLVDELTEGYAAQLAGRPANLPELAVQYPDFAAAHHTWLAGDEAARQIAHWREQLDGVLPLELAGDRPRPARPTFSGAAVRIDLDAQLVERADRLGRTEKATPFMVLLAAYAVVLHRWSAARDLVIGTAVAGRTRPESEPLIGFFVNTLPLRVTVDDAASFRELLRATRDSSLDGFARQDVPFPRIVREVGGERTSGRSALVRALFALRNVPLRHLELAGVRAETLNLPKTGSDIDLSLEFSPAEHGGGLTGWLSYSFDLFDQDTAERIARAVHQVLTAAIASDGDTAVRDLPVLTEEEHTTLALHWSGRDASAPGGDGLLDAFHAHALATPDATAVVADVPPPATGHRLTYRELDERAGRLAHLLRARGIGPEDRVALLLPRGLDLLVCLLAVLKAGAVLVPLESEHPAGRLAGIVADATPCLTLTDTRLAARLPEGTPVLTVEDLPTLTAHHPATGPDVPELPGSGAYVLYTSGSTGAPKGVLITRAGLANRLAGMCADLGLGADERVLHKTPLSADTSMWELLVALRSGGRVVLAAPGLGTDVDYLYSVLARHSVTTCFFVPSALRPAIGLGGLPRAAAALRLVISAGEELPADLADQLLLQVPHIRLVNSYGPTETTINIAEHTVTAPAASPVPIGRPVPGGDLYVLDGAGRVQPVGVPGELHAGGVQVARGYLGRPAQTAEVYVPHPFVPGARVYRTGDRARWRPDGTLEFLGRTDHQVKIRGFRVEPAEVETALRAHPQVADALVLAVAAPDGGARLVGYVTAAPGQSAPDTPALRTHLRAALPSPMVPDVFVALDAFPLTPYGKIDRAALPRPGRAPAKERRAPADDLQHVLAGVWEQTLEITDVSVDDDFFERGGHSVLATIVVSSIRELFRLELPLHFFVEAPTVATLATLMRAEGAEAGIDVDRVAALVRQVQSMSHNEVQQKLEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JNY0</accession>
    <name>A0A2M9JNY0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">TetR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_27855</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000013">
        <property type="protein sequence ID" value="PJN08583.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08583">
        <property type="protein sequence ID" value="PJN08583"/>
        <property type="gene ID" value="CG723_27855"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011075">
        <property type="entry name" value="TetR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16925">
        <property type="entry name" value="TetR_C_13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="1">
        <location>
            <begin position="2"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="domain" description="TetR_C" evidence="2">
        <location>
            <begin position="68"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00440"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF16925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN08583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="192" mass="20508" checksum="CB2018886651A203" modified="2018-04-25" version="1">MLRSTMTLLRVHGASATTVDRVLADSGAPRGSVYHHFPGGRTQMVEEAVALGGDLVTGMIETLAQAEDPVRAVDDFFARWRSQVEDSGFRSGCPIVAVAVETNDDAPQLARSAGQAFARWQKAFSALLRGHGLSEERSRRLAALIVAAEEGAVVLCRAQQSTAPMEDAAAEIHELLVQALSDRPETGDGTRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JP15</accession>
    <name>A0A2M9JP15_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Gamma-glutamyl-gamma-aminobutyrate hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CG723_27550</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000013">
        <property type="protein sequence ID" value="PJN08537.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08537">
        <property type="protein sequence ID" value="PJN08537"/>
        <property type="gene ID" value="CG723_27550"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016811">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011697">
        <property type="entry name" value="Peptidase_C26"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044668">
        <property type="entry name" value="PuuD-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43235">
        <property type="entry name" value="PTHR43235"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07722">
        <property type="entry name" value="Peptidase_C26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PJN08537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="238" mass="25069" checksum="D17A011A03231592" modified="2018-04-25" version="1">MSRPVIGIASYRDRARWNIWDTDATVLQQGYVDGVRRAGGRAVVLPPDDTDADVVARLDGLLLPGGADVDPARYGAARHPRTDTPSADRDAGELLLLEAALAAGLPVLGVCRGLQLLALAYGGTLHQHLPDLVGHSGHCPAEGVFGRHPVHLVPGSRAAALYGELAEVNSHHHQAVLDPGGLHVTGRGDDGVVEAAEDPSRPFVLGVQWHPEVSDDRKLFAAFVAACTTRSLHTAATV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JPJ4</accession>
    <name>A0A2M9JPJ4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">SUKH-3 domain containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CG723_27350</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000012">
        <property type="protein sequence ID" value="PJN08794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08794">
        <property type="protein sequence ID" value="PJN08794"/>
        <property type="gene ID" value="CG723_27350"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025850">
        <property type="entry name" value="SUKH-3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14433">
        <property type="entry name" value="SUKH-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PJN08794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="161" mass="17320" checksum="5861081F89BA323D" modified="2018-04-25" version="1">MTADRTRFTAPVDAALRAAGWQPGRWDIKQAEFWADALRTHVSPAGHRHTVFPAAVEAWAEFGGLHLTPQGPGRQIAPAQPHLDPLHGLHMARTLGDLGRALDTEVCPLGAESGSEALLAIDTEGRVYALDHSGDWYLGPDIDHALEALINGTRPTRLTAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JPK3</accession>
    <name>A0A2M9JPK3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_26460</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000012">
        <property type="protein sequence ID" value="PJN08801.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08801">
        <property type="protein sequence ID" value="PJN08801"/>
        <property type="gene ID" value="CG723_26460"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="35"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="64"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="107"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="140"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="180"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="238"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="317"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="341"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="387"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="421"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="459"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="493"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="271"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN08801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="534" mass="55452" checksum="AB5D870B312EC7E4" modified="2018-04-25" version="1">MAGRRQPVTTTTVTLVRLKLALLRNGLRGSTGRRAAYIATLVVVLLVAALQLIGLIALRGSTHAATLCVILTAVLALGWAVMPLFFPSGDETLDPTRLVMLPLRPHPLVRGLLIASLVGIGPLFTLCLAVGAVIALAHGAAASAVAVLAVALTLLTCVALARAVAAANIRLLTSRKGRDLAVLSGLVIAVGAQVVNFGAQRLGSSGGLGALDPAGDVLAWIPPASAIGAVDSVSHGSYGVAAARLVVCVAALAGLLYAWQRALTRLMTSPDGSTLQAAEPTRRRRTSRGPRLLPDGRTGTVMERALRYVWRDPKTKAAWVTSLAIGLIVPVFNALQGTGSIYFACFAAGMLGIQMYNQFGQDTSAFWMVAMTISSPRDAYVELRGRALALLTITLPYATLVTVVTTAMLDDWRALPEVLGLSFALLGAMLATGAWSSARFPYSIPQEGYKNVAPGQAGLAWISIFGGMVAAALLCAPVITLAIWLHVSGAESATWLLLPIGAAYAAGITLAGLRLAAPRTAARLPEILAAVSKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JPT6</accession>
    <name>A0A2M9JPT6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Threonylcarbamoyl-AMP synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_25695</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000011">
        <property type="protein sequence ID" value="PJN08889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08889">
        <property type="protein sequence ID" value="PJN08889"/>
        <property type="gene ID" value="CG723_25695"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003725">
        <property type="term" value="F:double-stranded RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017945">
        <property type="entry name" value="DHBP_synth_RibB-like_a/b_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006070">
        <property type="entry name" value="YrdC-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01300">
        <property type="entry name" value="Sua5_yciO_yrdC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55821">
        <property type="entry name" value="SSF55821"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00057">
        <property type="entry name" value="TIGR00057"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51163">
        <property type="entry name" value="YRDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YrdC-like" evidence="1">
        <location>
            <begin position="14"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN08889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="215" mass="22549" checksum="1074670722CFA88B" modified="2018-04-25" version="1">MARRYDTNDASDRTTGLREAASAVRRGELVVLPTDTVYGIGADAFTSEAVADLLDAKGRGRNMPTPVLIGSPNTLHGLVTDFSEMAWELVDAFWPGALTLVAKHQPSLAWDLGDTRGTVAVRMPLHPVAIELLTEVGPMAVSSANLTGHPAPEDCDAAQDMLGDSVSVYLDGGPTPGIVPSSIVDVTGKVPVLLRAGALTADELRKVVPDLEVAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JQ12</accession>
    <name>A0A2M9JQ12_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_25630</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000011">
        <property type="protein sequence ID" value="PJN08877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08877">
        <property type="protein sequence ID" value="PJN08877"/>
        <property type="gene ID" value="CG723_25630"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019675">
        <property type="entry name" value="DUF2550"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10739">
        <property type="entry name" value="DUF2550"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN08877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="149" mass="16410" checksum="59B1FA0CB2169473" modified="2018-04-25" version="1">MVLVLVLCVVAVVVFVLLGLFVFGLRRRLIQRSGGTFDCSLRWDVPEGGDASGKGWGYGVARYNGDRIEWFRVFSYAVRPRRTLERSAIEVTGRRAPEGEEELALLSDAIVLACSHRGSRLELAMSEDALTGFLAWLEAAPPGQRVNVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JQ26</accession>
    <name>A0A2M9JQ26_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Sugar hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_26185</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000011">
        <property type="protein sequence ID" value="PJN08974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08974">
        <property type="protein sequence ID" value="PJN08974"/>
        <property type="gene ID" value="CG723_26185"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001764">
        <property type="entry name" value="Glyco_hydro_3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036962">
        <property type="entry name" value="Glyco_hydro_3_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00933">
        <property type="entry name" value="Glyco_hydro_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00133">
        <property type="entry name" value="GLHYDRLASE3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glyco_hydro_3" evidence="2">
        <location>
            <begin position="41"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN08974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="497" mass="51166" checksum="C8B7D80219807871" modified="2018-04-25" version="1">MTTLTARGTDTLTRDALTVLQPGFTGTSAPDWLLRRLGEGLASVGLFGRNIASPEQLAALTAQLRAERDDVLVAIDEEGGDVTRLEVRSGSSFPGNHALGAVDDVELTRSVAAELGRRLAACGVNLNWAPSADVNSNPANPVIGVRSFGADTGLVSRHTAAYVTGLQSVGVAACTKHFPGHGDTAVDSHHDMPRIDVGLDVLYERELAPFRAAIEAGTRAVMSAHILVPALDPDRPATLSRRILTGLLREELGYEGLIVTDGMEMQAISATYGIERGSVLAIAAGADAICVGGGLADDDTVLRLRDALVAAVHAGDLPEERLADAAARVRSLARWASVPGAAEHSGGAPDTGIGLVAARRAVTVTRGEHAAPVTEAPYVAAFTPVANIAVGDETPWGVAAELERLLPGTETGSFSGTDAGAAALAAAGERRIVAVVRDAHRHAWMAQSLDTLLAARPDTVVVEMGVPQAPPQGALHVATHGAARVCGLAAAEVIVAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JQ46</accession>
    <name>A0A2M9JQ46_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Mycothiol system anti-sigma-R factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_26275</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000011">
        <property type="protein sequence ID" value="PJN08990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08990">
        <property type="protein sequence ID" value="PJN08990"/>
        <property type="gene ID" value="CG723_26275"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024020">
        <property type="entry name" value="Anit_sigma_mycothiol_RsrA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014295">
        <property type="entry name" value="Anti-sigma"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027383">
        <property type="entry name" value="Znf_put"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13490">
        <property type="entry name" value="zf-HC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02949">
        <property type="entry name" value="anti_SigH_actin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03988">
        <property type="entry name" value="antisig_RsrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="zf-HC2" evidence="1">
        <location>
            <begin position="11"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN08990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="103" mass="11602" checksum="AC98DDEBB68C9F5A" modified="2018-04-25" version="1">MSCGEHHETDCSEVLDHLYEFLDHEMPDSDCTKFETHFEECSPCLEKYGLEQAVKKLVKRCCGQDDVPSDLRSKVMGRIDLIRSGQAVPDQDVTASAPKLKEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JQ47</accession>
    <name>A0A2M9JQ47_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_26295</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000011">
        <property type="protein sequence ID" value="PJN08994.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08994">
        <property type="protein sequence ID" value="PJN08994"/>
        <property type="gene ID" value="CG723_26295"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="26"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="92"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="115"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="144"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="170"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="217"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN08994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="240" mass="25158" checksum="9BA107FF734B9702" modified="2018-04-25" version="1">MYVTASSGAADLWDRVFGSQSDPDQWVVFATAAAALAVIVPHNIWRLSRNAITIAHEGGHGIVALLSGRRLDGIRLHSDTSGLTVSRGKPSGLGMILTAAAGYTAPPLLGLGGAALLAAGHITALLWLATALLLALLVMIRNAYGALTVILTGGLFVLVSWLAGPQVQAAFAYVVVWFLLLGGVRPAFELQSKRRRGGAGDSDADQLSRLTHVPAGMWLFFFHAVSLCSLLGGGRWLLGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-05-25" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JQH0</accession>
    <name>A0A2M9JQH0_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase</fullName>
            <ecNumber evidence="7">2.7.7.60</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">4-diphosphocytidyl-2C-methyl-D-erythritol synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">MEP cytidylyltransferase</fullName>
            <shortName evidence="7">MCT</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">ispD</name>
        <name evidence="8" type="ORF">CG723_24710</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CB01635</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the formation of 4-diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate (MEP).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>2-C-methyl-D-erythritol 4-phosphate + CTP + H(+) = 4-CDP-2-C-methyl-D-erythritol + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:13429"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
            <dbReference type="ChEBI" id="CHEBI:57823"/>
            <dbReference type="ChEBI" id="CHEBI:58262"/>
            <dbReference type="EC" id="2.7.7.60"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 7">Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via DXP pathway; isopentenyl diphosphate from 1-deoxy-D-xylulose 5-phosphate: step 2/6.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the IspD/TarI cytidylyltransferase family. IspD subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.60" evidence="7"/>
    <dbReference type="EMBL" id="NNBL01000010">
        <property type="protein sequence ID" value="PJN09119.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN09119">
        <property type="protein sequence ID" value="PJN09119"/>
        <property type="gene ID" value="CG723_24710"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00056">
        <property type="reaction ID" value="UER00093"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050518">
        <property type="term" value="F:2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019288">
        <property type="term" value="P:isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016114">
        <property type="term" value="P:terpenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02516">
        <property type="entry name" value="CDP-ME_synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00108">
        <property type="entry name" value="IspD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001228">
        <property type="entry name" value="IspD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034683">
        <property type="entry name" value="IspD/TarI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018294">
        <property type="entry name" value="ISPD_synthase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01128">
        <property type="entry name" value="IspD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00453">
        <property type="entry name" value="ispD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01295">
        <property type="entry name" value="ISPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0414">Isoprene biosynthesis</keyword>
    <keyword evidence="5 7 8" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7 8" id="KW-0808">Transferase</keyword>
    <feature type="site" description="Transition state stabilizer" evidence="7">
        <location>
            <position position="22"/>
        </location>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="7">
        <location>
            <position position="29"/>
        </location>
    </feature>
    <feature type="site" description="Positions MEP for the nucleophilic attack" evidence="7">
        <location>
            <position position="171"/>
        </location>
    </feature>
    <feature type="site" description="Positions MEP for the nucleophilic attack" evidence="7">
        <location>
            <position position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009789"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PJN09119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="247" mass="25845" checksum="46F189CE2DFE505B" modified="2018-04-25" version="1">MSDETRPSRTAAVIPAAGRGVRLGPGAPKALRALNGTPMLIHAVRAMAASRSVSLVVVVAPPDEASAAEVKTLLADHALPERTDFVVVPGGETRQESVKLGLDALPPGIDVVLVHDAARPLVPVDTVDGVIEAVREGAPAVVPALPLADTVKQVEARTDGGPELVVATPERARLRAVQTPQGFDRATLVRAHETVTDNVTDDASMVEQLGEPVVVVPGHEEAFKVTRPLDLVLAEAVLARRRANDGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-09-29" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JQR5</accession>
    <name>A0A2M9JQR5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CG723_25210</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CB01635</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000010">
        <property type="protein sequence ID" value="PJN09210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN09210">
        <property type="protein sequence ID" value="PJN09210"/>
        <property type="gene ID" value="CG723_25210"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010290">
        <property type="entry name" value="TM_effector"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05977">
        <property type="entry name" value="MFS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="36"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="59"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="100"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="125"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="244"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="277"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="306"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="332"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="366"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="398"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="7">
        <location>
            <begin position="35"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PJN09210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="447" mass="47468" checksum="9D6F9F243EE40CC9" modified="2018-04-25" version="1">MSTGPGADSAPAPAALDKTDRPGKSSMFSSLKIRNYRLFATGAVVSNTGTWMARITQDWLVLSITGSSAAVGITTAMQFLPMLLFGLYGGVIADRFAKRNLLFVTQGAMSLSGLFLATLTLTGNVQVWHVYLAAFFTGLVTVVDNPTRQSFVSEMVGPDQVRNAVSLNSANFQSARLIGPAVASGLTAAVGPGWAFLANGLSFLAPLTSLCLMRTRELHHTPRAPRGKGQLREGLNYVSKHPELIWPIVLVGFVGTFGFNFPIWLSAYADDVFHGGVGMYGVFNTLMALGSLAGALLAARRRSTRLRVLAGAAVGFGVLEVVAAFAPDVWVFAPLIVLLGILGLTVNVTANSSVQMATDPEMRGRVMSLFMMVFTGGTPFGGPLFGWLADQYGVRLSFAIGGLVCATAALGVGLMLARAANLRLKLDLRRGRQHVQFVPREHLATAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JQW9</accession>
    <name>A0A2M9JQW9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">SAM-dependent methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_23235</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000009">
        <property type="protein sequence ID" value="PJN09269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN09269">
        <property type="protein sequence ID" value="PJN09269"/>
        <property type="gene ID" value="CG723_23235"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041698">
        <property type="entry name" value="Methyltransf_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13649">
        <property type="entry name" value="Methyltransf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransf_25" evidence="1">
        <location>
            <begin position="29"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN09269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="189" mass="20873" checksum="AA6573828208976A" modified="2018-04-25" version="1">MAYPLSPGSGRSPRVLWNTASCRCHTRYVGCGSGRITAHLRQLGLDAFGIDLSPGMIEVARRDHPDLRFELGSMTDLDLADGSMVGLVAWYSLIHIPDTEIDTVFKHFHRVLQPGGSLLLSFHVGDESKMKTEGYGGHPMKVHVHRRRHSQMTGWLNEAGFTVDQHSTLTSAESTLGGIILARRQPDTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JQX7</accession>
    <name>A0A2M9JQX7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CG723_23210</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000009">
        <property type="protein sequence ID" value="PJN09265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN09265">
        <property type="protein sequence ID" value="PJN09265"/>
        <property type="gene ID" value="CG723_23210"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PJN09265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="343" mass="37073" checksum="4671470E129FE8B6" modified="2018-04-25" version="1">MHDLASVDLLDAFTRELRLCKLQPGEHVVVLSEPTSRGDYIAAAFGAAKACDAHVISATVPGGNPAPADSTRTGAGPGLTSVLNDTTAQEMLKAADLVVDLTREGFIHAPLQQEILRAGTRIIFVCDAPDVLIRNLPKEDDKVRVLKGVELLKSASVMRVTSEAGTELTVELPGSKPEFQVGFADDPGRWDHWPSTMVLCWPQLSDGRIVLTEGDILLPFKEYVRRPVTLEIAGGNIEKVSGGAEAQLLNTYFEDADDQWARSLSHMGWGLMKTADWFATALYGKEELMGMDARAFAGNFLWSTGPHPVLGRESYAHIDVAMRGCTVSVDSTDVVTAGRLVEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JR37</accession>
    <name>A0A2M9JR37_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Beta-N-acetylhexosaminidase</fullName>
            <ecNumber evidence="3">3.2.1.52</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CG723_23500</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CB01635</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal non-reducing N-acetyl-D-hexosamine residues in N-acetyl-beta-D-hexosaminides.</text>
            <dbReference type="EC" id="3.2.1.52"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 20 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.52" evidence="3"/>
    <dbReference type="EMBL" id="NNBL01000009">
        <property type="protein sequence ID" value="PJN09314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN09314">
        <property type="protein sequence ID" value="PJN09314"/>
        <property type="gene ID" value="CG723_23500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004563">
        <property type="term" value="F:beta-N-acetylhexosaminidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102148">
        <property type="term" value="F:N-acetyl-beta-D-galactosaminidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.379.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025705">
        <property type="entry name" value="Beta_hexosaminidase_sua/sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015883">
        <property type="entry name" value="Glyco_hydro_20_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029018">
        <property type="entry name" value="Hex-like_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015882">
        <property type="entry name" value="HEX_bac_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22600">
        <property type="entry name" value="PTHR22600"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00728">
        <property type="entry name" value="Glyco_hydro_20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02838">
        <property type="entry name" value="Glyco_hydro_20b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00738">
        <property type="entry name" value="GLHYDRLASE20"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55545">
        <property type="entry name" value="SSF55545"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glyco_hydro_20b" evidence="7">
        <location>
            <begin position="3"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_hydro_20" evidence="6">
        <location>
            <begin position="146"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PJN09314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="535" mass="57070" checksum="B086D7E732987771" modified="2018-04-25" version="1">MNAVIPSPTEQAAQGGAGSLAAAGPWRIRADRSLSEVADTVRALLAPHLGMRLLPEGDPQDHGSEIVLTLDATGVPLGTTVGVAPTGTAEPADEAYALTAGADGITCRSRTPEGVFRAATSAAQLLLTTPPDGTIEALQLRDAPHYAWRGLMIDPARSFITPDEVRRVIDLAALYKLNVLHLHLTDNEGWRIEVPSLPALTAGQAASGPAAFYSADEYRDLQSYAARHFVTIVPEIDLPGHCAALRAALPDLPPAPAPEGLADRFPFVPPLDLADAATHTAVSAVLADVCALTDGPFVHIGCDEAVGIMEDAFHVAVDELRSITRKLGKRPVAWQESSRAGAGPQDIAQFWVDVPMMDLPGSAEELAARPELTASGMTMEIAAALKSFFAPSDHDVERVLAGGGRLLLSPQSHLYLDRRYAPEVTPPGQAEVAARLGFPHYRPRDVRHTASWDPASHGIPDESVAGVEATLFGETLQGIDDLTTLLLPRLGSVAETAWSGRPPLWAEYRERIARHALLWRDRGLVHFAADDVPWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JR50</accession>
    <name>A0A2M9JR50_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PAS sensor protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_23740</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000009">
        <property type="protein sequence ID" value="PJN09349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN09349">
        <property type="protein sequence ID" value="PJN09349"/>
        <property type="gene ID" value="CG723_23740"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013656">
        <property type="entry name" value="PAS_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13185">
        <property type="entry name" value="GAF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08448">
        <property type="entry name" value="PAS_4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07228">
        <property type="entry name" value="SpoIIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00065">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00331">
        <property type="entry name" value="PP2C_SIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="SSF81606"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PAS" evidence="1">
        <location>
            <begin position="24"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="domain" description="PAS" evidence="1">
        <location>
            <begin position="139"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN09349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="691" mass="73832" checksum="4AA4950522818199" modified="2018-04-25" version="1">MSEAGSFSADSGSSDLRLELPSGVLDALGVAVVALDTAGRFVWWGPQAEELFGYSAQEVLGQHAAQLLVHDPDMDLVAGKCEQMMETGESWAGLIPVRNKDGSTRLVEFRYNRLPDKQGDFYALGIATDVSTLRKVEQDLALSTQLIAQSPVALEVLDTDLRYVAVNPAMERIHGLSAEDHLGRGFREVLPSDSVDASEAAVREVLKTGRPLVDKYTIGRTPADPDRDHAWSVSVYRLEDPNGQVLGVATSVVDVTDRHGAITAAAQARQRLAQIAEGSARIGTTLDMKQTARELADVAVPELADLAVVDVLDSALDDRRPATPDSGPALFRTLAVKAAYLAEATGAAGTADQLVSYDADRLPTQCVRTGQPILVTRVDEWDLARIARDAGAAAVLASVGIHSYLAIPLAAQGRALGVLGLMRGRNQLPFNADDVTLAGELASRTAVSLDNARLYQSVRNTAVTLQRSLLPQPTPSESLEIATRYQPAGTSTEVGGDWFDVIPLTEDKTALVVGDVMGSGIDAAATMGRLRTATATLADLDLPPAQVLQRLDKITTGLDPYIATCIYAEYDPRSDRCRIATAGHLPPALTPAGGPPELLDLPSGAPLGVGGVPFETTTVPLRPGDQLVLYTDGLVETRRDAIDERLDLLLRVLESHDLSLEETCDRLLEALCDPDDHDDVSVLIARPRPRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JR65</accession>
    <name>A0A2M9JR65_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_23935</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000009">
        <property type="protein sequence ID" value="PJN09380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN09380">
        <property type="protein sequence ID" value="PJN09380"/>
        <property type="gene ID" value="CG723_23935"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004104">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02894">
        <property type="entry name" value="GFO_IDH_MocA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GFO_IDH_MocA" evidence="1">
        <location>
            <begin position="4"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="GFO_IDH_MocA_C" evidence="2">
        <location>
            <begin position="141"/>
            <end position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN09380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="367" mass="40133" checksum="96D8EFDD0D0DD963" modified="2018-04-25" version="1">MTLSIGVLGLGSVFQGPYSSLITKLQHEGRVELVAGYDPDPAKRATAAERFGIDTSFVGPQDLIGRADLDIVLVLTSMNEHGSLARAALEAGKHVLVEKPMSTSLEEAAELMRYAATAPGQLVCAPHVALSPTYREMHRRVRDGEIGDIHLARARYGWAGPWWGRWFYEQGGGAMFDLGVYNLTSLCGFLGSVKRVTAMVGVAVPKREAEGEKVTVRSDDNAHIVLDFGDARFASIATGFTLQKYRSPAVELYGSAGTMQMLGDDWAPEGFEQWTNARGSWEIVGESDPNWPWTDGLRHLVDCVENGTRTLTRPEHAYHALEVMLAAKRSAEEGRVVEIRSAFPDFAYDGAEHTAQDGRGKHDPRSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JRF4</accession>
    <name>A0A2M9JRF4_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Methyltransf_11 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_22115</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000008">
        <property type="protein sequence ID" value="PJN09470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN09470">
        <property type="protein sequence ID" value="PJN09470"/>
        <property type="gene ID" value="CG723_22115"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Methyltransf_11" evidence="1">
        <location>
            <begin position="80"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN09470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="161" mass="16746" checksum="42F849BF555ECE9A" modified="2018-04-25" version="1">MLPSPDGKPLPPNDTAAAFRAFARDLAAGRRTWTTEAAGSLSDLFDQLAGSWDSDQATGREDPLHDALARGGPFLRGTCLEIGSGTGLFTPTLAATFGTVISIDLSEQMLRQAAGRSPIRVRADASALPRADASLSVVAAIDMLLFPHELATHDGGTEGDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JS55</accession>
    <name>A0A2M9JS55_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">FAD-dependent oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_21085</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000007">
        <property type="protein sequence ID" value="PJN09699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN09699">
        <property type="protein sequence ID" value="PJN09699"/>
        <property type="gene ID" value="CG723_21085"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD_binding_3" evidence="1">
        <location>
            <begin position="16"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN09699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="418" mass="45537" checksum="D84D52C652833600" modified="2018-04-25" version="1">MKTTHTAYASTRLSHLDVLVSGASVAGPAVALALSLHGARVTVVEKAPALREGGFAVDFRGWVHRTVLTALGIHDDIHARQTHMGRQTVVDADGTPRLDLPAELMSGDVEIFRGDLSRILHEHSKDSVEYVFGDSIATLTQDDNGVDVTFERAAPRRFDLVVAADGLHSPTRRLVFGDESRYLRFLDHYVAGFGIPNHLGLDRTGRLYSDPGRAVCVSNYDGDPDRAGALLVFRSEPLDHDRRDVDQQKRILAERFEGMGWEAPRVLKALEDADDLYFDAIAQIHVDRLTKGRVVLLGDAGYGATMGGMGTGVAIVGAYVLAGELALADGDHRTAFAAYEAQIGDFAKGCQKISGNAGPFFAPPTERRIRSRDRMYRLLSSRLMAGFFKRLTEKAATALDLKDYPALLDAPAAVVRGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JSC7</accession>
    <name>A0A2M9JSC7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">TetR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_21355</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000007">
        <property type="protein sequence ID" value="PJN09752.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN09752">
        <property type="protein sequence ID" value="PJN09752"/>
        <property type="gene ID" value="CG723_21355"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="6"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="29"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN09752.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="185" mass="19587" checksum="DF973A8D9ABEE72A" modified="2018-04-25" version="1">MAEHRSMQRGALLDAARSLLSEGGTEALTFPALAERTGLARSSVYEYFRSRAAVVEELCEVDFPVWAAEVSTAMERAGTPEGKVEAYVREQLSLVGDRRHRAVVAISASELDSGAREKIRAAHGGLVAMIVEALADMGHAEPRLAAMLLQGVVDAAVRRIELGAAEDPSAITEAAVSMALRGVSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-06-02" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JSJ3</accession>
    <name>A0A2M9JSJ3_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Phosphatidate cytidylyltransferase</fullName>
            <ecNumber evidence="7">2.7.7.41</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CG723_21385</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CB01635</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>a 1,2-diacyl-sn-glycero-3-phosphate + CTP + H(+) = a CDP-1,2-diacyl-sn-glycerol + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:16229"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
            <dbReference type="ChEBI" id="CHEBI:58332"/>
            <dbReference type="ChEBI" id="CHEBI:58608"/>
            <dbReference type="EC" id="2.7.7.41"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="7">Phospholipid metabolism; CDP-diacylglycerol biosynthesis; CDP-diacylglycerol from sn-glycerol 3-phosphate: step 3/3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the CDS family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.41" evidence="7"/>
    <dbReference type="EMBL" id="NNBL01000007">
        <property type="protein sequence ID" value="PJN09757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN09757">
        <property type="protein sequence ID" value="PJN09757"/>
        <property type="gene ID" value="CG723_21385"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00557">
        <property type="reaction ID" value="UER00614"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004605">
        <property type="term" value="F:phosphatidate cytidylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016024">
        <property type="term" value="P:CDP-diacylglycerol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000374">
        <property type="entry name" value="PC_trans"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01315">
        <property type="entry name" value="CDS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 10" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 7 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="154"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="178"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="206"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="230"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="259"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="286"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="326"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="400"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="55"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="78"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="96"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003938"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PJN09757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="418" mass="43941" checksum="FDF43BE8D7417A9C" modified="2018-04-25" version="1">MNDSSWGAPTGAGYWGPPDQGPSQGASPAGPAYEQHAVEETRPMPIVPEMPEVPAGGRDQDDDRGAARPSGPLFRDESQGGSRHEDPRGGQHEPQHQTQHEPQQQTQNQTHRPTQHQTPYVTPHEAQHESLQEPMPSAAQPAPAPPKKSAGRDLGAAIGVGVGLGAVIVASLFIVKAVFVGVVAVAVVVGLWELTSRLEERKGIKAPLVPLAIGGAAMVVAGYVRGTEGAWVAMALTALAVLVWRMTEPPEGYLRDVTAGVFAAFYVPFLATFVALMLTADDGPQRVLTFLLLTVVSDTGAYAIGWRFGKHKLAPRISPGKTREGLVGAVTFAMAAGALCMQFLIDGGAWWQGLLLGLAVAASATLGDLGESMIKRDLGIKDMGTLLPGHGGIMDRLDSLLPTAPVVWLLLVIFVGAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JTD8</accession>
    <name>A0A2M9JTD8_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5 7">50S ribosomal protein L15</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">rplO</name>
        <name evidence="10" type="ORF">CG723_20230</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CB01635</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Binds to the 23S rRNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Part of the 50S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5 6">Belongs to the universal ribosomal protein uL15 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000006">
        <property type="protein sequence ID" value="PJN10047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN10047">
        <property type="protein sequence ID" value="PJN10047"/>
        <property type="gene ID" value="CG723_20230"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015934">
        <property type="term" value="C:large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01341">
        <property type="entry name" value="Ribosomal_L15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036227">
        <property type="entry name" value="L18e/L15P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030878">
        <property type="entry name" value="Ribosomal_L15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005749">
        <property type="entry name" value="Ribosomal_L15_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001196">
        <property type="entry name" value="Ribosomal_L15_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021131">
        <property type="entry name" value="Ribosomal_L18e/L15P"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12934">
        <property type="entry name" value="PTHR12934"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00828">
        <property type="entry name" value="Ribosomal_L27A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52080">
        <property type="entry name" value="SSF52080"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01071">
        <property type="entry name" value="rplO_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00475">
        <property type="entry name" value="RIBOSOMAL_L15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 5 6" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="Ribosomal_L18e/L15P" evidence="9">
        <location>
            <begin position="32"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00029547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01341"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PJN10047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="151" mass="16035" checksum="00B817A30147955D" modified="2018-04-25" version="1">MAENNPLKIHNLRPAPGAKTAKTRVGRGEASKGKTAGRGTKGTKARYQVPERFEGGQMPLHMRLPKLKGFKNPFKTEFQVVNLDKLSALYPEGGEVTVEGLVAKGAVRKNSLVKVLGQGELTVALQVTVDAVSNSAKEKITAAGGTVTELV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JTX9</accession>
    <name>A0A2M9JTX9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">B/F/G family RNA polymerase sigma-70 factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CG723_18355</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000005">
        <property type="protein sequence ID" value="PJN10340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN10340">
        <property type="protein sequence ID" value="PJN10340"/>
        <property type="gene ID" value="CG723_18355"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014322">
        <property type="entry name" value="RNA_pol_sigma-B/F/G"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000943">
        <property type="entry name" value="RNA_pol_sigma70"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007630">
        <property type="entry name" value="RNA_pol_sigma70_r4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04545">
        <property type="entry name" value="Sigma70_r4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00046">
        <property type="entry name" value="SIGMA70FCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02980">
        <property type="entry name" value="SigBFG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0731">Sigma factor</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="6">
        <location>
            <begin position="49"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4" evidence="7">
        <location>
            <begin position="217"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PJN10340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="280" mass="30908" checksum="5D1070ED0EF6860F" modified="2018-04-25" version="1">MLTDITAGPTHRRRTSRHAHDDSPDTTAAFARMAGLAEGPERDLLCEELVEAWLPMAHRIARRYRNKGESTEDLEQVAAMGLVKAINHYRPERGPFQCYAVPTITGELRRHFRDRMWDVHVPRRVQDLRNKVRAARRDLTDRPGSPEPGVGAIAAHAGLTEAEVLDGLKAIESYSALSLDAELSPSGHDGQSLADALGAPDTAYDLITDREAAKTGLSHLPERERAILYLRFFEGMTQARIAEKFGISQMHVSRLIHLSCARVRAEAGREYGAADGVTAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-06-02" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JU88</accession>
    <name>A0A2M9JU88_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_19060</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000005">
        <property type="protein sequence ID" value="PJN10455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN10455">
        <property type="protein sequence ID" value="PJN10455"/>
        <property type="gene ID" value="CG723_19060"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="17"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN10455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="148" mass="15685" checksum="F0F314F5AE5D01D6" modified="2018-04-25" version="1">MAPAGLAGPAATPAQATDNVPCHNTVKRDLTDPSSGRTWPGTAVMYCNLTRGHVPVHASRSPGSPVVGHLTQGGAANWFVTEMKGETYRDGAAENNWWASTRADNGRWGWTPEVHFAGGGNYEDDASLLMPGSYTCANTCAPVPFRAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JUB4</accession>
    <name>A0A2M9JUB4_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Porphobilinogen deaminase</fullName>
            <shortName evidence="6">PBG</shortName>
            <ecNumber evidence="6">2.5.1.61</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Hydroxymethylbilane synthase</fullName>
            <shortName evidence="6">HMBS</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Pre-uroporphyrinogen synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6 9" type="primary">hemC</name>
        <name evidence="9" type="ORF">CG723_18810</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CB01635</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 6">Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>H2O + 4 porphobilinogen = hydroxymethylbilane + 4 NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:13185"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:57845"/>
            <dbReference type="ChEBI" id="CHEBI:58126"/>
            <dbReference type="EC" id="2.5.1.61"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>dipyrromethane</name>
            <dbReference type="ChEBI" id="CHEBI:60342"/>
        </cofactor>
        <text evidence="6">Binds 1 dipyrromethane group covalently.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Monomer.</text>
    </comment>
    <comment type="miscellaneous">
        <text evidence="6">The porphobilinogen subunits are added to the dipyrromethane group.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 6">Belongs to the HMBS family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.61" evidence="6"/>
    <dbReference type="EMBL" id="NNBL01000005">
        <property type="protein sequence ID" value="PJN10412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN10412">
        <property type="protein sequence ID" value="PJN10412"/>
        <property type="gene ID" value="CG723_18810"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004418">
        <property type="term" value="F:hydroxymethylbilane synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018160">
        <property type="term" value="P:peptidyl-pyrromethane cofactor linkage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006779">
        <property type="term" value="P:porphyrin-containing compound biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00260">
        <property type="entry name" value="Porphobil_deam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000860">
        <property type="entry name" value="HemC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022419">
        <property type="entry name" value="Porphobilin_deaminase_cofac_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022417">
        <property type="entry name" value="Porphobilin_deaminase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022418">
        <property type="entry name" value="Porphobilinogen_deaminase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036803">
        <property type="entry name" value="Porphobilinogen_deaminase_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11557">
        <property type="entry name" value="PTHR11557"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01379">
        <property type="entry name" value="Porphobil_deam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03900">
        <property type="entry name" value="Porphobil_deamC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001438">
        <property type="entry name" value="4pyrrol_synth_OHMeBilane_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00151">
        <property type="entry name" value="PORPHBDMNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54782">
        <property type="entry name" value="SSF54782"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00212">
        <property type="entry name" value="hemC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00533">
        <property type="entry name" value="PORPHOBILINOGEN_DEAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0627">Porphyrin biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Porphobil_deam" evidence="7">
        <location>
            <begin position="7"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="domain" description="Porphobil_deamC" evidence="8">
        <location>
            <begin position="229"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="modified residue" description="S-(dipyrrolylmethanemethyl)cysteine" evidence="6">
        <location>
            <position position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00260"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF03900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PJN10412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="311" mass="32871" checksum="F46E35AD04EE6A25" modified="2018-04-25" version="1">MSAPELIRIVSRDSPMALAQVERVRAELAALHPGIRTSVVPVKTTGDKWMGDLSVVEGKGAFTKEVDAALLAGEADLAVHCVKDVPADRPLPAGTVFAAFLKRDDIRDALIHPDGLTLDQLPSGTRIGTSSVRRIAQVSAAYPHLDCVPMRGNANRRLEKLAAGDADALLLAAAGLERIGRTDVITEVLSPEVMCPPIGAGILALQCREGDTDLIDTISGLGDPDAHREASAERMFLHVLQGHCNSPIAGFARAERSGDLSLRACVFTPDGKTVLNAHEWAGPLDPATLGTSVAVALMRQGARELIDSISH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JUC9</accession>
    <name>A0A2M9JUC9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CG723_18655</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000005">
        <property type="protein sequence ID" value="PJN10506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN10506">
        <property type="protein sequence ID" value="PJN10506"/>
        <property type="gene ID" value="CG723_18655"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="SSF48371"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PJN10506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="268" mass="29783" checksum="2794A0661E88C8BE" modified="2018-04-25" version="1">MFVHLTPQANAARIRRAGIRAVSRHRDGGRGVYCFPVLASYTLTHQWLRELARHGGPRGLVAVQVRLPDDEPVTVGRYNRDPLATTAGDAVRRLAAMDDPRGWEVFLPRAVTKREVQRVRAVRQVTGWRYFPNAHGVVPCTCAGCRVRGEYGSRRLRERRPHPDDGPPPPAPVLLRRVEAAGEPGDATALCEALRWFGLRRRGPVARLSRLVDHPEPAVREALADAVAGWSTPGVDALLERLAADPDADVRELAAAVVERREERRTPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JUD9</accession>
    <name>A0A2M9JUD9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">RNA polymerase subunit sigma-70</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CG723_17735</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000005">
        <property type="protein sequence ID" value="PJN10483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN10483">
        <property type="protein sequence ID" value="PJN10483"/>
        <property type="gene ID" value="CG723_17735"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PJN10483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="73" mass="8149" checksum="942281AFB5F0D907" modified="2018-04-25" version="1">MESTLEIAEGAASSDPDTGLRAVAALRELTERLEILQVENARKLGWSWQDIAERLGVTKQTVHRKYGRLIGSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JUI3</accession>
    <name>A0A2M9JUI3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_14955</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000004">
        <property type="protein sequence ID" value="PJN10523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN10523">
        <property type="protein sequence ID" value="PJN10523"/>
        <property type="gene ID" value="CG723_14955"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="39"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN10523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="63" mass="6731" checksum="5EC15788B790B381" modified="2018-04-25" version="1">MTYDRLVCANCAAPVSEGRCPVCRANRERLQQESPFAGLHPMALIALVAVLIAAVALLAHQTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JUN3</accession>
    <name>A0A2M9JUN3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_15305</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000004">
        <property type="protein sequence ID" value="PJN10584.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN10584">
        <property type="protein sequence ID" value="PJN10584"/>
        <property type="gene ID" value="CG723_15305"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="9"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="33"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="87"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN10584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="112" mass="10924" checksum="2E92966C436CCF89" modified="2018-04-25" version="1">MPRPTAAQLAYGSATVIFSTLAMLLLSQTSSGLGVAVIALAALGLGLLVALTVPLPKSRPAAAPAPATAGAGVVTEERVPVQRATVPAAAQQAAPESVYEVAPSGTRGPAGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JV66</accession>
    <name>A0A2M9JV66_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glyoxalase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_16365</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000004">
        <property type="protein sequence ID" value="PJN10759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN10759">
        <property type="protein sequence ID" value="PJN10759"/>
        <property type="gene ID" value="CG723_16365"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VOC" evidence="1">
        <location>
            <begin position="5"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN10759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="146" mass="15982" checksum="8D4646492859A492" modified="2018-04-25" version="1">MAIQRMDNVGIVVEDMDAAIAFFVELGMELEGRAEVEGLVADQCTGLDGVRCDIAMVRTPDGHSRLELAKYRSPAVIGAGPRNRPHNILGTHRVMFAVDDIEDTVARLRPHGAELVGEIARFEDSYLLCYLRGPEGIIVGLAEQLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JVB1</accession>
    <name>A0A2M9JVB1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Sugar ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CG723_16495</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CB01635</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000004">
        <property type="protein sequence ID" value="PJN10778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN10778">
        <property type="protein sequence ID" value="PJN10778"/>
        <property type="gene ID" value="CG723_16495"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="39"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="102"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="136"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="167"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="210"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="269"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="98"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PJN10778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="305" mass="33986" checksum="FE51B86132AFC483" modified="2018-04-25" version="1">MTSTTLSPTPTPTAAPAGASRRRGPAAARARRKRVLHWIAVHSVAIAVALLFILPFVFVFLTSVMSDSQAMSGDLWPDSWHWDNYKTVFQTDGFLDWWKNSLLYAGLGTLFTVCSAIPVAYALAKFRFRGRRTAMMLVISTMMLPPQVIVIPMYLVWAQQFHLSGTLWPLIIPMAFGDAYSIFLLRQFLLTIPKEYIESAKVDGCGELRTLLKIIVPMAKPGIAAIALFQFFYCWNDYFGPQIYAAQNPASWTLSYGLESFKSAHSVNWNLTMAATLLVMAPVCIVFFFAQKAFVEGVTLTGVKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JVJ0</accession>
    <name>A0A2M9JVJ0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Extradiol dioxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_17080</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000004">
        <property type="protein sequence ID" value="PJN10879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN10879">
        <property type="protein sequence ID" value="PJN10879"/>
        <property type="gene ID" value="CG723_17080"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004360">
        <property type="entry name" value="Glyas_Fos-R_dOase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00903">
        <property type="entry name" value="Glyoxalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VOC" evidence="1">
        <location>
            <begin position="2"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN10879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="130" mass="14307" checksum="05D8ADEA29EEFEFD" modified="2018-04-25" version="1">MELAQVRLLVSDFRACYHFYADVLGLKPQSGAEDGPYEKFSPTAGSAGIGLEDRALMAQVIGDLSDAPDGHRSLVVLRVDDLDEYCEQIVARGAEILHGPAPMTDRMRVAHLKDPEGNIVELQEWLLMRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JVL5</accession>
    <name>A0A2M9JVL5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcriptional repressor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_17265</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Fur family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000004">
        <property type="protein sequence ID" value="PJN10909.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN10909">
        <property type="protein sequence ID" value="PJN10909"/>
        <property type="gene ID" value="CG723_17265"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07153">
        <property type="entry name" value="Fur_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002481">
        <property type="entry name" value="FUR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043135">
        <property type="entry name" value="Fur_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33202">
        <property type="entry name" value="PTHR33202"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01475">
        <property type="entry name" value="FUR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN10909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="137" mass="14697" checksum="8649477773ACB4C2" modified="2018-04-25" version="1">MGAPVRGRSTRQRAAVAAALDEVDEFRSAQELHDVLKHKGDSVGLTTVYRTLQSLADAGEVDVLRTSDGEAVYRRCSSGEHHHHLVCRVCGKAVEVEGPAVEKWAEAIASEHGYVNVAHTVEIFGTCAECARAAAES</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-09-29" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JVN0</accession>
    <name>A0A2M9JVN0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_17160</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000004">
        <property type="protein sequence ID" value="PJN10892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN10892">
        <property type="protein sequence ID" value="PJN10892"/>
        <property type="gene ID" value="CG723_17160"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041413">
        <property type="entry name" value="MLTR_LBD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17765">
        <property type="entry name" value="MLTR_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="34"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN10892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="277" mass="30783" checksum="52E5B1CD59CEBB38" modified="2018-04-25" version="1">MNRAELADFLRRSRARLAPSDVGLTAGPRRRTPGLRREEVAQLAGMSTDYYTRLEQRRGSHPSRQMLTALARALRLNDAERDHLFHLAGEEPPRPGRSSGHVRPGLLLILDRLHDLPASVISDWGEMLAQNTMSVALTGDHTGRNVIRDWFTNPATRPMFPPENHEAHARAHVASLRAVAAARPDDPGPAALVAELRAGSREFEELWQSHDVVVRRPSPKRFLHPVVGALDLDCEVLLSDGHDQQLVVHSAQPGTETYERLELLRVVGLQDLTPSTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JWM3</accession>
    <name>A0A2M9JWM3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Serine/threonine protein phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_10200</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN11295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN11295">
        <property type="protein sequence ID" value="PJN11295"/>
        <property type="gene ID" value="CG723_10200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005532">
        <property type="entry name" value="SUMF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042095">
        <property type="entry name" value="SUMF_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03781">
        <property type="entry name" value="FGE-sulfatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="SSF56436"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FGE-sulfatase" evidence="2">
        <location>
            <begin position="40"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="34"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN11295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="317" mass="34278" checksum="899FC6B1DE106F2F" modified="2018-04-25" version="1">MTAEDVTPKACCAARREGGGEPQPVRLAPTARRASGKGLATLPGGTFRMGNEDDRANPGDGEGPVREVTVGPFRIDEHAVTNAQFATFVKDTGFVTAAERFGWSYVFAGFLDPRLARATPAPAGTPWWRGVEGATWRAPEGPGSGIGDRSRHPVIHVSWDDASAYAAWAGKRLPTEAEWEYAARGGLDQARYPWGDELTPRGHWRCNIWQGEFPVVNTGEDGHTGTAPVDAYRPNAYGLHNTVGNVWEWVADRFTTDHPAAPLTDPRGPAEGDTRVMRGGSYMCHDSYCNRYRVAARTANTPDSSSGNCGFRCAADV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JXF0</accession>
    <name>A0A2M9JXF0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">GNAT family N-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_11385</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN11498.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN11498">
        <property type="protein sequence ID" value="PJN11498"/>
        <property type="gene ID" value="CG723_11385"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="2">
        <location>
            <begin position="27"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN11498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="177" mass="19707" checksum="08314C5169A95658" modified="2018-04-25" version="1">MDTRTTEYAEPPGQKGSEAARPPGVRWELRAAGPADVEPIAELRAVVMRPDLVRLGRYDEHRVRQRLRDTFSERYTSVVLADGAFVGSVTMRPAQSGGQWIEHFYLAPEQQGRGLGTAVLRALLDRADAAGETVRLDVVQGSAARRLYERHGFTLESEDPIDVFLVRAPRVMPEARP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-09-29" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JXI1</accession>
    <name>A0A2M9JXI1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CG723_11925</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN11591.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN11591">
        <property type="protein sequence ID" value="PJN11591"/>
        <property type="gene ID" value="CG723_11925"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PJN11591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="348" mass="37951" checksum="4A07D019FBED0EBE" modified="2018-04-25" version="1">MYGKAFAPEYQGELRTALGVNSSYEDVRAAAGRSLDTAAGPLERARAALALAEANRRLGRVREAGDAWRSSYRSARTAGHTGAMAWALWNGGTLARQCGSLRLARRLLGHAVTLAAHSDDRLAHGYALAGLAETGRIQGDYAAVAALHEELLEQGRVHGEPRHMVWAMSGIAQIHRNTGDHAKALELFEESVRVATEADDARGRAWSLRGVADVLSVRGEPDRALSLLSEAEGICRAMDLASALAYNHKMRANVLYRDGRYEAARDAYASTLAEFRRLHEPRGVALCRLGLVKSRSRLGRDRRDTLAELDVLEADFTRIGLRHAREMVVAFRAETAPGALRPGRREAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-09-29" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JXM2</accession>
    <name>A0A2M9JXM2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_11540</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN11527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN11527">
        <property type="protein sequence ID" value="PJN11527"/>
        <property type="gene ID" value="CG723_11540"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002397">
        <property type="entry name" value="Cyt_P450_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00359">
        <property type="entry name" value="BP450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="SSF48264"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN11527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="416" mass="44613" checksum="EBFD5DD6D6F2F0F7" modified="2018-04-25" version="1">MTIPPVVPHRIDPAGGCPHAANARLLDQGVVAPVVLPGDVEGMVVLGHDALKDFLAHPDVAKSARHFTALVEGHIPDGWPLMTFATVQGMTTADDEDHRRLRSLVSRAFTARRVEALRPRVEELTGELLDALEAAVAEGEDVVELRRQFALPLPMSVICELLGVDEEFRGRLHHLSGQVVATDIGPREAVAANRELVSVLAAVAASRASRPGDELTSALIAAREEDGDRLSEQELIGTLLLMIVAGHETTLNLVTNAVRALCAHRDQLDLVLSGGASWSDVVEETLRWDSPVSYFPFRYPTRDLTVDGTVIPRGTPVLAGYSAAGRDRSAHGPDADRFDVTRASAARHISLGHGPHYCLGAPLARMEATVALERLFTRFPGLDLAVPDAELARKAGFVGNSVDQLPVRLRPVAGAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JY16</accession>
    <name>A0A2M9JY16_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Glycosyl hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CG723_12405</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN11667.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN11667">
        <property type="protein sequence ID" value="PJN11667"/>
        <property type="gene ID" value="CG723_12405"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PJN11667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="423" mass="46194" checksum="0674AF793F1B93DD" modified="2018-04-25" version="1">MTSAVRFGVNYTPSQGWFHHWLDFDLDAVRADLDSIAALGLDHIRVFPLWPYFQPNRTLIRPRAVEQLVQLADAAAERGLDVNVDGLQGHLSSFDFLPAWTQTWHRRNLFTDPDVVEGQEAYLRTLAGALADRPNFIGMTIGNEVNQFAAGPHPDPDRITAEQAGSWLRRVLAACEEGAPGRTHLHASYDAAWYQDDQPFTPAHSARLGALTAVHSWVFNGTAQRHGRTGTATEHHAAYLVELSKAWAGDPHRPVWLQEVGAPAPLVPAEHAAHFTEATVENALDCPDLWGVTWWCSHDVSRDLADFPELEYSLGLLTSERQPKPAAKALARIVADRRARPCAPAPRTTALVVDAGDDEAAPNRSVCAPGGAVFEAFARLTADGARPTTVLAGRADDKEHLMARGITEVVTPDHVTRTVGTAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JZA4</accession>
    <name>A0A2M9JZA4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Amino acid adenylation protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CG723_12570</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CB01635</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Antibiotic biosynthesis.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN12188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN12188">
        <property type="protein sequence ID" value="PJN12188"/>
        <property type="gene ID" value="CG723_12570"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00705"/>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017000">
        <property type="term" value="P:antibiotic biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901362">
        <property type="term" value="P:organic cyclic compound biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030639">
        <property type="term" value="P:polyketide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010071">
        <property type="entry name" value="AA_adenyl_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018357">
        <property type="entry name" value="Hexapep_transf_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012728">
        <property type="entry name" value="NRPS_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="SSF47336"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="SSF51161"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01733">
        <property type="entry name" value="AA-adenyl-dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02353">
        <property type="entry name" value="NRPS_term_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00101">
        <property type="entry name" value="HEXAPEP_TRANSFERASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0045">Antibiotic biosynthesis</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 5" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="598"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="635"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="829"/>
            <end position="854"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="874"/>
            <end position="896"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="1072"/>
            <end position="1097"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="1103"/>
            <end position="1128"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="7">
        <location>
            <begin position="503"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="5">
        <location>
            <position position="538"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PJN12188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="1287" mass="135099" checksum="BE94C219E5BC9236" modified="2018-04-25" version="1">MALFTAGPAAPARTLMNIFGASVRDHRDEPALDDGSKQLTYRALADEVENLRVRLALAGVRRGDRVGVRVPSGTNDLYIAILGVLAVGAAYVPVDAEDPDERAELVFGEARVRVVIGAGHDLTAWGPDGTEERGIRTPPGSANCLPGTEDDAWIIFTSGSTGKPKGVAVPHRSAAAFVDAEAALFLADEPIGPGDRVMAGLSVAFDASCEEMWLAWRNGACLVPVPRSRVRSGADLGPWLVEQDISVVSTVPTLAALWEPQVLDDVRLLIFGGEACPPELAQRLVTEGREVWNTYGPTEATVVACACLMTGEEPVRIGLPLDGWELAVVDEAGAPVTLGATGELVIGGAGLARYLDPAKDAEKYAPLPSLGWERAYRSGDLVRADPEGLVFLGRGDEQIKLGGRRIELGEVDTALQALPGVAGAAAAVRTARSGNQLLVGYVVTQDGWDRAGAVERLRAALPAALVPLLAPVESLPTRTSGKVDRAALPWPLPDLETSTGPAEQLYGTEAWLAEQWAHTLGVSVTVAKDDFFAIGGSSLAAAQLTTRLRTRYPSAAVLDIYQHPTLRKLARHLEESAQGKETHRDVGPVPVRAQIVQLLLLLPLFTLVGLRWCVALAALGNVLHRFGSYAWAPAVSWWWVAAGAVVLFSPAGRLALAAGGARLLLRGVEPGTYPRGGQVHLRLWTAERLAEYSGATSLTGSWLLRYARALGARIGADVDLHSLPPVTGMLKLGRGCAVEADVDLSGHWLDGDRLVIGAVKVGGGAVVGTRSLLFPGARVGKKAEVAPGSAVTAQIPTGQRWAGSPAVKLGKAKRDWPKQRPKRSYGWRLMYGASGLALSALPALAAVPALAVALRFVAVDTGLGEALRGAQLAVVPAALAFGCAYALLLLGAVRLLSLGLRPGLHPTHSRTGWQAWTVTQLMDAARQTLFPLYAGLVTPLWLRLLGMKIGRGAEVSTVLALPSLTTVGDGAFLADDTLTAPYELGGGWVRIGRAAIGRRAFLGNSGMTGPGRSVPDGGLVGVLSATPKKAKKGTSYLGLPPMKLPRAPEGGDHSRTYDPPARLLWARGAVELFRLVPVFCSAALAVLTGGVLCALAGATGVGWWAAAALSGAVLLGAGIVGALAAVAAKWLLVGRHRAGEHPLWSGFVWRDELADTFVEVVAVPWLIGAVPGTPLMTLWLRGLGARVGRGVWCESYWLPETDLVTLGSAVSVNRGCVLQTHLFHDRILRMDKVALGAGSTVGPGGIVLPGSTVGARATLGPASLVMAAESVPDDTRWLGNPIEAWRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-06-02" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JZK1</accession>
    <name>A0A2M9JZK1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_04360</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000002">
        <property type="protein sequence ID" value="PJN12296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN12296">
        <property type="protein sequence ID" value="PJN12296"/>
        <property type="gene ID" value="CG723_04360"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021424">
        <property type="entry name" value="PorA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11271">
        <property type="entry name" value="PorA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="287"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="312"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="320"/>
            <end position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN12296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="336" mass="36059" checksum="894D58822AF7BFBC" modified="2018-04-25" version="1">MRRTASPFSLLTLGLGAFLLALAPLLAWYVEPRAELTPVDVDTTTVFTGTGSYFDTGAVKTVRGKRITVTRQVRGDVAASEKSGRAVWDVSTSVDTDASLPAADPHDALQWTLERWVTDRRTNAPVHCCGEQPSFEGEAYLKFPFDVQRRAYRWWDNTLGATVTLSYRGTKKVQGYEGYRFTGTVPATKTGSRLVPGTIVGQPKRNQVLAEEWYANHGIELVVDKKTGRIVHAAIGPRKTLRAPGSAKDAVVLLDSERIAFTPATQRRQVALADDDSGRLHLLGTTLPLTAGAAGLALAALGAVFVVRGRGGRGGTGGRGPSNPDSSPTVLEPSTM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JZN0</accession>
    <name>A0A2M9JZN0_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">3-oxoacyl-[acyl-carrier-protein] synthase 3</fullName>
            <ecNumber evidence="8">2.3.1.180</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">3-oxoacyl-[acyl-carrier-protein] synthase III</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Beta-ketoacyl-ACP synthase III</fullName>
            <shortName evidence="8">KAS III</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">fabH</name>
        <name evidence="11" type="ORF">CG723_04515</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CB01635</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched-chain and/or straight-chain of fatty acids.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>acetyl-CoA + H(+) + malonyl-[ACP] = 3-oxobutanoyl-[ACP] + CO2 + CoA</text>
            <dbReference type="Rhea" id="RHEA:12080"/>
            <dbReference type="Rhea" id="RHEA-COMP:9623"/>
            <dbReference type="Rhea" id="RHEA-COMP:9625"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:78449"/>
            <dbReference type="ChEBI" id="CHEBI:78450"/>
            <dbReference type="EC" id="2.3.1.180"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="8">Lipid metabolism; fatty acid biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="8">The last Arg residue of the ACP-binding site is essential for the weak association between ACP/AcpP and FabH.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the thiolase-like superfamily. FabH family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.180" evidence="8"/>
    <dbReference type="EMBL" id="NNBL01000002">
        <property type="protein sequence ID" value="PJN12324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN12324">
        <property type="protein sequence ID" value="PJN12324"/>
        <property type="gene ID" value="CG723_04515"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00094"/>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004315">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033818">
        <property type="term" value="F:beta-ketoacyl-acyl-carrier-protein synthase III activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01815">
        <property type="entry name" value="FabH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013751">
        <property type="entry name" value="ACP_syn_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013747">
        <property type="entry name" value="ACP_syn_III_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004655">
        <property type="entry name" value="FabH_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08545">
        <property type="entry name" value="ACP_syn_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08541">
        <property type="entry name" value="ACP_syn_III_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00747">
        <property type="entry name" value="fabH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="2 8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 8" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="5 8" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="3 8" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="6 8" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="ACP_syn_III" evidence="10">
        <location>
            <begin position="116"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="domain" description="ACP_syn_III_C" evidence="9">
        <location>
            <begin position="252"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="region of interest" description="ACP-binding" evidence="8">
        <location>
            <begin position="269"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="122"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="268"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF08541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF08545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PJN12324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="343" mass="35960" checksum="7FD87BDD70A4509F" modified="2018-04-25" version="1">MSKIKPSQGAPYARIMGVGGYRPTRVVPNEVILETIDSSDEWIRSRSGIATRHWASDSETVAAMSIEASGKAIADAGISAERIGAVVVSTVSHFKQTPAIATEIADKLGTAKAAAFDISAGCAGFGYGLTLAKGMIVEGSAEYVLVIGVERLSDLTDLEDRATAFLFGDGAGAVVVGPSQEPHIGPTVWGSEGDKSETIKQTVPWDEFRVGDVSKLPLDSKGDIKFPAITQEGQAVFRWAVFEMAKVAQQALDAAGISADDLDVFIPHQANMRIIDSMVKTLKLPEHVTVARDIETTGNTSAASIPLAMERLLATGKAKSGDTALVIGFGAGLVYAATVVTLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JZU6</accession>
    <name>A0A2M9JZU6_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HTH_30 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_04825</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000002">
        <property type="protein sequence ID" value="PJN12378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN12378">
        <property type="protein sequence ID" value="PJN12378"/>
        <property type="gene ID" value="CG723_04825"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2840">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025736">
        <property type="entry name" value="PucR_C-HTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042070">
        <property type="entry name" value="PucR_C-HTH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13556">
        <property type="entry name" value="HTH_30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH_30" evidence="1">
        <location>
            <begin position="344"/>
            <end position="402"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN12378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="415" mass="45571" checksum="3A3715D3BC843485" modified="2018-04-25" version="1">MPSAAPSSEVEEPLGPLPPEFATIMRPELPSLIKEIRVEVTRTYPEFAQLLNGPNSAVVRLGVEQSLSAFVDRVAEPSAPAGERDELCRRFGRFEAYEGRSLDSLHGAYRIGARIALRRAKRVGRQYNLSPTLILTFADALFAYVDELEALSREGYLEVQSHSAAHLDSLHRRILHLLLAGHPLPGGALAELCDQAGWRVPEQVTLVALRAPAPARIRAGLDPDVLADLSDPQPHLLIPGPLEDPADPDGEARARLDRLTAALGDTRCVLGLTVPTARAGDSIRWARRILDLVDEQIIADAPAVRCADHLTTLWLLSDPALLDRLAARELAPLSGLTGSRRARLIDTLRVWLTTRGTADHVGDILGVHAQTVRYRLRNLDAHFGDRLTDPEHRFATEAALRARHLQGHRHQSEDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JZZ5</accession>
    <name>A0A2M9JZZ5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Phenazine biosynthesis protein PhzC/PhzF</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CG723_05300</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000002">
        <property type="protein sequence ID" value="PJN12455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN12455">
        <property type="protein sequence ID" value="PJN12455"/>
        <property type="gene ID" value="CG723_05300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003719">
        <property type="entry name" value="Phenazine_PhzF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13774">
        <property type="entry name" value="PTHR13774"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02567">
        <property type="entry name" value="PhzC-PhzF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PJN12455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="213" mass="23101" checksum="F4DB99CA271C74A1" modified="2018-04-25" version="1">MTDYDVLRVFCGPHGDHGNELGVVREGSDVPDEHERQALAAKLGFSETVFVDDPERGVIDIYTPTLRLPFAGHPCVGTAWLLDVPELVTPAGVVGTRLDGEFTWIEARPEWAPPRTLREYASASEVEELQVPPPGEWVYAWAWEDTAAGKVRARAFPGRGDGIDEDEATGAAALLLTAQLHRALNITQGKGSQILTAPQPEGLIEVGGRVRLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K0K0</accession>
    <name>A0A2M9K0K0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">DNA-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CG723_06295</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000002">
        <property type="protein sequence ID" value="PJN12636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN12636">
        <property type="protein sequence ID" value="PJN12636"/>
        <property type="gene ID" value="CG723_06295"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037187">
        <property type="entry name" value="DnaK_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020460">
        <property type="entry name" value="Znf_C4-type_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000962">
        <property type="entry name" value="Znf_DskA_TraR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020458">
        <property type="entry name" value="Znf_DskA_TraR_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01258">
        <property type="entry name" value="zf-dskA_traR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00618">
        <property type="entry name" value="DKSAZNFINGER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109635">
        <property type="entry name" value="SSF109635"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01102">
        <property type="entry name" value="ZF_DKSA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51128">
        <property type="entry name" value="ZF_DKSA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="DksA C4-type" evidence="6">
        <location>
            <begin position="249"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="dksA C4-type" evidence="4">
        <location>
            <begin position="292"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="25"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="239"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="78"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="243"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00510"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PJN12636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="324" mass="33008" checksum="5F43DDD7B77FCD24" modified="2018-04-25" version="1">MVAKKRPVGVREASAGVKVAVEEAGPAKAAADAAPAAKKPAAGKKSIATKTAARKSAGTKSAAAKKTAKAAKAAAETVTKTANKTARSAKAAKSTKATKATQSADTAQASEEAESVVAEEGAAGRTGARKNAVKKATGHKSAEKKAVASAADGAASAAETTGATTVVAKKTPGTATAKKPRAVPNARVAAVEPGELAVRPGEDPWTPAEVAEARAELQSEALRLNSEIESSEKALVGLMRDSGDGAGDDEADTGTKNITREHELSLAANAREMLQQTERALERLDAGTYGICENCGNPIGKARMQAFPRATLCVECKQKQERRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K0L0</accession>
    <name>A0A2M9K0L0_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 10">Cytochrome bc1 complex cytochrome c subunit</fullName>
            <ecNumber evidence="3 10">7.1.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CG723_05910</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">CB01635</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9 10">
            <text>a quinol + 2 Fe(III)-[cytochrome c](out) = a quinone + 2 Fe(II)-[cytochrome c](out) + 2 H(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:11484"/>
            <dbReference type="Rhea" id="RHEA-COMP:10350"/>
            <dbReference type="Rhea" id="RHEA-COMP:14399"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
            <dbReference type="EC" id="7.1.1.8"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="10">The cytochrome bc1 complex is composed of a cytochrome b (QcrB), the Rieske iron-sulfur protein (QcrA) and a diheme cytochrome c (QcrC) subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 10">Cell membrane</location>
            <topology evidence="2 10">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="11">Binds 2 heme groups covalently per subunit.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.1.1.8" evidence="3 10"/>
    <dbReference type="EMBL" id="NNBL01000002">
        <property type="protein sequence ID" value="PJN12567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN12567">
        <property type="protein sequence ID" value="PJN12567"/>
        <property type="gene ID" value="CG723_05910"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070469">
        <property type="term" value="C:respirasome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008121">
        <property type="term" value="F:ubiquinol-cytochrome-c reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.760.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009152">
        <property type="entry name" value="bc1_cytC-su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009056">
        <property type="entry name" value="Cyt_c-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036909">
        <property type="entry name" value="Cyt_c-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00034">
        <property type="entry name" value="Cytochrom_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13442">
        <property type="entry name" value="Cytochrome_CBB3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000007">
        <property type="entry name" value="Ubiq_cycred_cyc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46626">
        <property type="entry name" value="SSF46626"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51007">
        <property type="entry name" value="CYTC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10" id="KW-0249">Electron transport</keyword>
    <keyword evidence="5 10 11" id="KW-0349">Heme</keyword>
    <keyword evidence="8 10 12" id="KW-0408">Iron</keyword>
    <keyword evidence="15" id="KW-0456">Lyase</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 10 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="13" id="KW-0732">Signal</keyword>
    <keyword evidence="7 10" id="KW-1278">Translocase</keyword>
    <keyword evidence="10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="10" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014611697" description="Cytochrome bc1 complex cytochrome c subunit" evidence="13">
        <location>
            <begin position="41"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="242"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome c" evidence="14">
        <location>
            <begin position="47"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome c" evidence="14">
        <location>
            <begin position="142"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="binding site" description="covalent" evidence="11">
        <location>
            <position position="60"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" description="covalent" evidence="11">
        <location>
            <position position="63"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="12">
        <location>
            <position position="64"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
            <label>1</label>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <feature type="binding site" description="covalent" evidence="11">
        <location>
            <position position="155"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" description="covalent" evidence="11">
        <location>
            <position position="158"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="12">
        <location>
            <position position="159"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
            <label>2</label>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012951"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00017819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00029351"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR000007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR000007-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR000007-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="PJN12567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="269" mass="27575" checksum="70F4169E715AE720" modified="2018-04-25" version="1">MKKLSARRRHPLAAVVVLLLALAATGGLYAAFAPASKAQADETAQSLAIDEGKKLYAVGCASCHGTGGQGSSDGPPLTGVGAAAVDFQVGTGRMPAQQPGAQIPKKKVIYSQAEIDQLAAYVASLGAGPTVPTKNQVSPEGADIANGGELFRTNCAQCHNFTGEGGALTHGKFAPNLEDVSPKHIYEAMQTGPQNMPSFPDTTMPEKSKKDIIAYINAVNGNETESPGGLTLGGLGPFTEGLFAWVFGLGALVAVAVWVAARTAKAKKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-09-29" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K0V1</accession>
    <name>A0A2M9K0V1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CG723_06965</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000002">
        <property type="protein sequence ID" value="PJN12746.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN12746">
        <property type="protein sequence ID" value="PJN12746"/>
        <property type="gene ID" value="CG723_06965"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PJN12746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="137" mass="14748" checksum="8D7238264D84F203" modified="2018-04-25" version="1">MPTRTPIGAARTRPCTLVVCRGCCCGNAAKYPGYDHAWQLERLRAAADSSGGRVAVRVTDCLGPCDQANVMVVQPSGEGRRRGGRPAWVGWSMGDDATDEILRWAEAGGPGIAPAPAALELQFIETPGERTRRRTRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K113</accession>
    <name>A0A2M9K113_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">L-lysine N6-monooxygenase MbtG</fullName>
            <ecNumber evidence="5">1.14.13.59</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Lysine 6-N-hydroxylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Lysine N6-hydroxylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Lysine-N-oxygenase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Mycobactin synthase protein G</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CG723_06790</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CB01635</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>L-lysine + NADPH + O2 = H2O + N(6)-hydroxy-L-lysine + NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:23228"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:32551"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:57820"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.14.13.59"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Siderophore biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the lysine N(6)-hydroxylase/L-ornithine N(5)-oxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.13.59" evidence="5"/>
    <dbReference type="EMBL" id="NNBL01000002">
        <property type="protein sequence ID" value="PJN12717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN12717">
        <property type="protein sequence ID" value="PJN12717"/>
        <property type="gene ID" value="CG723_06790"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00193"/>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047091">
        <property type="term" value="F:L-lysine 6-monooxygenase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044249">
        <property type="term" value="P:cellular biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901566">
        <property type="term" value="P:organonitrogen compound biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025700">
        <property type="entry name" value="Lys/Orn_oxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42802">
        <property type="entry name" value="PTHR42802"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13434">
        <property type="entry name" value="K_oxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00016406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00029939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00032493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00032738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PJN12717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="478" mass="53988" checksum="A1A4CC98C5FBA7A2" modified="2018-04-25" version="1">MTTAPTPKPPHPEAPRDLVGIGIGPFNLSLAALAHPLTELDTAFYEQHPAFHWHPGLLIDGATLQVPFLADLVTLADPASPWSFLNYLKTRDRLFPFYFAERFHIQRAEYDAYCRWVSENLPGLHFGHQIDAVRWNPERRLFEVDFTQLDTEGEAEALGRTYTRNVVLGVGTAPYIPEPLRPLAEAPTVPVIHSTDYLTHRTELLAADHITVIGSGQSGAEIFLDLLKNRPQGREKLHWLARSEAFAPMEYSKLGLEHFTPDYTRYFHHLPEDVRDQLVPAQWQLHKGIDTETIAAIHDELYQRTLHGGWPDATLTPGVCVRTAGRVATTKVELHLEHRRQNTRSRLTTDAVVLATGYRERPLDHMLTGLDPHLRRDNSERPRIDEQFRLVLDHTVTDTGSNIYVQNAERHTHGVGAPDLGLAAWRSATILNTLTGKDPYPLPQRTAFTTFGLTPNENRAPRTQSGERGITHLIELKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K1C9</accession>
    <name>A0A2M9K1C9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Peptidase C69</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CG723_07950</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CB01635</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase U62 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000002">
        <property type="protein sequence ID" value="PJN12928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN12928">
        <property type="protein sequence ID" value="PJN12928"/>
        <property type="gene ID" value="CG723_07950"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045569">
        <property type="entry name" value="Metalloprtase-TldD/E_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002510">
        <property type="entry name" value="Metalloprtase-TldD/E_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035068">
        <property type="entry name" value="TldD/PmbA_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036059">
        <property type="entry name" value="TldD/PmbA_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01523">
        <property type="entry name" value="PmbA_TldD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19289">
        <property type="entry name" value="PmbA_TldD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111283">
        <property type="entry name" value="SSF111283"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PmbA_TldD" evidence="2">
        <location>
            <begin position="33"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="domain" description="PmbA_TldD_C" evidence="3">
        <location>
            <begin position="253"/>
            <end position="498"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF19289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PJN12928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="507" mass="54531" checksum="7FF35E0B5AA37A5D" modified="2018-04-25" version="1">MPHSIDEAFTALPLRALADAALARARALGADHADFRLERVRSAERRLRDARPAGSSDTTDLGYAVRVVHGGTWGFASGVDLTMDAAAKVASQAVAMAKLSAQVIKAAGSDERVELAAEPAHEDRTWVSSYEIDPFCVPDEEKAGLLADWSARLLGADGVDHVDASLLTVHENKFYADTAGTVTTQQRVRLHPQLTAVAVDGTSGEFDSMRTLAPPVGRGWEYLTGTGWDWDRELAEIPELLAEKMRAPSVEAGLYDLVVDPSNLWLTIHESIGHATELDRALGYEAAYAGTSFATFDQLGKLKYGSEIMNVTGDRTAEHGLATIGYDDEGVAGQSWDLVRDGTLVGYQLDRRIAKLTGFDRSNGCAYADSPGHVPVQRMANVSLQPDPGGLSTEDLIGGVDRGIYVVGDRSWSIDMQRYNFQFTGQRFYRIENGRLAGQLRDVAYQATTTDFWGSMAAVGGPQTYVLGGAFNCGKAQPGQVAAVSHGCPSALFKGVNILNTTQEAGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K1D5</accession>
    <name>A0A2M9K1D5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DNA-binding response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CG723_08030</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000002">
        <property type="protein sequence ID" value="PJN12942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN12942">
        <property type="protein sequence ID" value="PJN12942"/>
        <property type="gene ID" value="CG723_08030"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00622">
        <property type="entry name" value="HTH_LUXR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="7"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="domain" description="HTH luxR-type" evidence="3">
        <location>
            <begin position="146"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PJN12942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="214" mass="23110" checksum="B321438FB1297AB8" modified="2018-04-25" version="1">MADNRIRVLLVDDHQVVRRGLRTFLEVQDDIEVVGEASDGAEGVALTEELKPDVVLMDVKMPVMDGVEALRKLRELANPARVLIVTSFTEQRTVVPALRAGAAGYVYKDVDPDALAGAIRSVHAGHVLLQPEVAGALLSQEETNGGQGRGNSLTEREREVLGLIADGRSNREIARALVLSEKTVKTHVSNILMKLDLADRTQAALWAVRHGAAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K1H2</accession>
    <name>A0A2M9K1H2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Cobalt ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CG723_04940</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CB01635</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000002">
        <property type="protein sequence ID" value="PJN12975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN12975">
        <property type="protein sequence ID" value="PJN12975"/>
        <property type="gene ID" value="CG723_04940"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003339">
        <property type="entry name" value="ABC/ECF_trnsptr_transmembrane"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02361">
        <property type="entry name" value="CbiQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="50"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="143"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="227"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="252"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="284"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="326"/>
            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PJN12975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="358" mass="36695" checksum="7314488495891995" modified="2018-04-25" version="1">MHPGAWWLWALGLGTAASRTTNPLLLALLIGVAGYVVAARRTSAPWARSYGAFVKLGLAVIGIRLVFAVFLGSPIPGTHLLVTLPEVPLPEWAQGVRIGGRVTVEGLVFALYDGLKLAALLICVGAANALASPARLLKSLPGALYEAGVAVVVAMTFAPNLIADVRRLRAARRLRGRPDKGLRGLAQVGLPVLEGALERSVALAAAMDARGYGRTAEVPVAVRRATAVLTLGGLVGVCAGTYGLLTADGARYGLPVLLAGVAAALGGLWLGGRRSVRTRYRPDVWGVRAWLVAASGAAVAAVMIRAGSYDPSALAPGVVPLAAPTLPLWPAAGVLLGLLPAFVAPAPPLAETPSKEAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K1J3</accession>
    <name>A0A2M9K1J3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Dienelactone hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_06320</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000002">
        <property type="protein sequence ID" value="PJN13001.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN13001">
        <property type="protein sequence ID" value="PJN13001"/>
        <property type="gene ID" value="CG723_06320"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002925">
        <property type="entry name" value="Dienelactn_hydro"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01738">
        <property type="entry name" value="DLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DLH" evidence="1">
        <location>
            <begin position="3"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN13001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="189" mass="20750" checksum="6E922B2D8B8B518F" modified="2018-04-25" version="1">MNIMLFHSTYGLRPAVRDAADRLRAAGHEVWTPDLFEGRTFDTVEEGMAFNEEIGKDELLKRAILAAAPYSERGLVYAGFSLGASIAQTLALGDDKARGLLLLHGTSDIAENASVDELPVQLHVAEPDPFETDDWLSAWYLQMGRTGADVEVYRYAGAGHLYTDPELPDYDAEAAEATWRVALGFLDSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K1T6</accession>
    <name>A0A2M9K1T6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">TerD-family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_00315</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000001">
        <property type="protein sequence ID" value="PJN13085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN13085">
        <property type="protein sequence ID" value="PJN13085"/>
        <property type="gene ID" value="CG723_00315"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06974">
        <property type="entry name" value="TerD_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003325">
        <property type="entry name" value="TerD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02342">
        <property type="entry name" value="TerD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TerD" evidence="1">
        <location>
            <begin position="5"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN13085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="175" mass="18679" checksum="CA26498AFAF2B27D" modified="2018-04-25" version="1">MSSFKKGLKKVEVALKWDPSPIGQPPHDLDIIAATYTSDDPGGAPAYVVHFDSRSPDGTITLNRDSTTGQGFGYDEVMTLELERLSPSYARVVVGIAIQQGERATVFGAVANTAVRIREGYTGLAQNDFSEVADSTAAVIAEFARDDSGEWAFREVLQGYDSDPTSFAAAMGGAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K212</accession>
    <name>A0A2M9K212_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CG723_00720</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000001">
        <property type="protein sequence ID" value="PJN13155.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN13155">
        <property type="protein sequence ID" value="PJN13155"/>
        <property type="gene ID" value="CG723_00720"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PJN13155.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="64" mass="6720" checksum="52544814B5BB8390" modified="2018-04-25" version="1">MLPVLTQDDENALGGPAGFLIRPRVETGGMPPPAGVFFVLPGGISLPSVARAGERFLSAFLRVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K247</accession>
    <name>A0A2M9K247_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_00680</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000001">
        <property type="protein sequence ID" value="PJN13150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN13150">
        <property type="protein sequence ID" value="PJN13150"/>
        <property type="gene ID" value="CG723_00680"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001845">
        <property type="entry name" value="HTH_ArsR_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01022">
        <property type="entry name" value="HTH_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00778">
        <property type="entry name" value="HTHARSR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00418">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50987">
        <property type="entry name" value="HTH_ARSR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH arsR-type" evidence="1">
        <location>
            <begin position="24"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN13150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="131" mass="14195" checksum="691ABB4D5C42D234" modified="2018-04-25" version="1">MWKRTTTVVTRVRDFGDRPAFDDPPAEVIAEAAGAFGLLASSARLHIVWALAQGESDVTGLAERVGGALPAVSQHLTKLKLAGLVRSRREGRRQVYFVDDPDIVAVVRLLIGRLAERADRTPARRLRGAGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K255</accession>
    <name>A0A2M9K255_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Mannosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CG723_00445</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000001">
        <property type="protein sequence ID" value="PJN13107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN13107">
        <property type="protein sequence ID" value="PJN13107"/>
        <property type="gene ID" value="CG723_00445"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="9"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="46"/>
            <end position="53"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PJN13107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="271" mass="29360" checksum="E8C5266F3193C906" modified="2018-04-25" version="1">MSTDTGPAIELRGASKTFRTPSGGLHTAVRELDLTVGRGEFVAVVGPTGCGKSTTLTLVSGLEEPTDGEVLVAGEPVEGVGDKVGFVFQQDATFPWRTVLSNVMAGPRFRGVPKAEAKAKAREWLARVGLASFEDRYPHQLSGGQRKRVALAATFVNDPEILLMDEPFSALDVQTRALMSDELLELWEGTGASVVFVTHDLEESIALADKVVVMTAGPATVKQVFDIALPRPRKVESVRLLPEFIEIYREIWESLGEEVRITRERGAADVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-09-29" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K2C3</accession>
    <name>A0A2M9K2C3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CG723_01490</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CB01635</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000001">
        <property type="protein sequence ID" value="PJN13284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN13284">
        <property type="protein sequence ID" value="PJN13284"/>
        <property type="gene ID" value="CG723_01490"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="21"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="52"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="85"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="112"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="162"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="188"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="231"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="265"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="292"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="317"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="351"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="380"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="228"/>
            <end position="422"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PJN13284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="422" mass="41877" checksum="189854B8F54CF323" modified="2018-04-25" version="1">MAQAAGGTSATYREVLGATGVVLPVISFLGRLPVAVIQFGSVLLITRTSGSLATGGTVACALALGQVAMGPVVGRLADRRGQRSVVLCCSLLNAVAIACYTLGALAGPSTPLLVALGVLAGATVPGIGPLARARGVALVRRGGADERVVNTVLSLESTMDELSFVLGPALIGVASFVGHPAYAFGAAALLVAACGTAFALHPTATAVRPAGAPTPKEPRARRPRMPREVRLVRLGLVLLGILLGGCGAGITALTQKLGQEDQAGLVYAAMGVMSAVVGVSMAAVPERFGLALRWRVATAAAALLSLLLIGTQSMPGLYVAVTVFGAVFAPNLITGFGLTERAVPGERLAEGMTFAASAFVGGQAVTLAVAGRLAESHGPAAAFTVGSVAAALAFGVALLVKAPAEPRVTPAAAAPSGSGRGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K2H4</accession>
    <name>A0A2M9K2H4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Poly-gamma-glutamate synthase PgsB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">pgsB</name>
        <name evidence="3" type="ORF">CG723_01155</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000001">
        <property type="protein sequence ID" value="PJN13227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN13227">
        <property type="protein sequence ID" value="PJN13227"/>
        <property type="gene ID" value="CG723_01155"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016879">
        <property type="term" value="F:ligase activity, forming carbon-nitrogen bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045227">
        <property type="term" value="P:capsule polysaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008337">
        <property type="entry name" value="Capsule_biosynth_CapB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036565">
        <property type="entry name" value="Mur-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013221">
        <property type="entry name" value="Mur_ligase_cen"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08245">
        <property type="entry name" value="Mur_ligase_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01758">
        <property type="entry name" value="CAPSULEPROTB"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53623">
        <property type="entry name" value="SSF53623"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04012">
        <property type="entry name" value="poly_gGlu_PgsB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mur_ligase_M" evidence="2">
        <location>
            <begin position="41"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="449"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="492"/>
            <end position="506"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN13227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="517" mass="57086" checksum="D55CD218FCDC3B8A" modified="2018-04-25" version="1">MLFLYTVLVVCGAVLLIAGIVEQRRHFANLEHIPTRVLVNGIRGKSSITRLCAGALRGGDLTTVAKTTGTAARFIHPDATEEPVYRKFGIANVVEQIGIVRRAAAYNPDALVIECMAVMPALQEINQSKLIRSTIGVLCNVREDHLAEMGPTLDDVARSLCRSMPEGGICVTAEQERFHILQEEADARDCKLIYADPETVSDEELRGFSWFTFKENVAIALTVAELVGVDRDTALQGMYDAPPDPGVLSVERYLTHDNKKLRFANVFAANDPESTLMNINQLLDLGAIHRPLNVVINCRPDRVERNGQMGEIIPELDPDQVFVIGHPAKSAIDAIPAAYRDRAVDLGGDRREAEEFMGKLLGSLGPDSSLVAIGNIHGQGEHLLEHLAELPADESDDPADRFEPAESSWQDAPAVPEHIETVQLYAPRIDPYQQYPEAYETRYTPPLHIPVQRDADHPHPGYQDPQPLREAWPAVTQHQPVQPAEQTVPRGPFEPRIPPAPPAEDPQQWHSSPGEPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K3R8</accession>
    <name>A0A2M9K3R8_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Alpha-amylase</fullName>
            <ecNumber evidence="3">3.2.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CG723_02785</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CB01635</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Endohydrolysis of (1-&gt;4)-alpha-D-glucosidic linkages in polysaccharides containing three or more (1-&gt;4)-alpha-linked D-glucose units.</text>
            <dbReference type="EC" id="3.2.1.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.1" evidence="3"/>
    <dbReference type="EMBL" id="NNBL01000001">
        <property type="protein sequence ID" value="PJN13778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN13778">
        <property type="protein sequence ID" value="PJN13778"/>
        <property type="gene ID" value="CG723_02785"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004556">
        <property type="term" value="F:alpha-amylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013784">
        <property type="entry name" value="Carb-bd-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008969">
        <property type="entry name" value="CarboxyPept-like_regulatory"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004638">
        <property type="entry name" value="EmrB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49452">
        <property type="entry name" value="SSF49452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49464">
        <property type="entry name" value="SSF49464"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00711">
        <property type="entry name" value="efflux_EmrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="37"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="67"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="91"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="125"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="152"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="186"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="219"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="253"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="293"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="321"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="349"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="457"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="8">
        <location>
            <begin position="2"/>
            <end position="480"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012595"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PJN13778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="758" mass="78520" checksum="DD56F38D5B9D21E7" modified="2018-04-25" version="1">MVFFGLMLALLLAALDQMIVATALPKVVGELHGLDKMSWAITAYLLTATIGLPIYGKLGDLFGRKGVFQFAIAVFVVGSALAGWSRNMDELIAFRAVQGIGAGGLMIGVQAIIADIVPPRERGRYMGLIGAAFGLASVAGPLLGGYFTDHLTWRWCFYINVPFGLVTLAVVTVVLKLPRPKVKAELDILGALLLAAASTCLVLLTSWGGTEYAWGSRVILGLAAGAAVTAVLFVVAEHFAAEPIIPLRLFRDPVFNITSLVGMVIGIALFGAASYLPTFLQMVDGASATESGLLMLPMMGGIVIASIVSGQLISRTGHYKIYPILGGALSTAGMWLLSRLEVDTPRLHYSLYMAVLGAGIGLIMPVLILAVQNAVRPADIGTATSANNYFRQIGGSVGAAIFGTLFADRLADALADRLPKGAGLPDPESITPQLVHALPRALRDGYIQAYADAMPRIFLYLVPVLVLGLVIAFFLKETPLLSSAAPHSAPSGETTSVPSQARTSYGAGVPVCGIVQHPDGTAVPRAALTLIDVGGQQIGRGASGDDGRYALSTPGAGSYVLIAAAGGHQPQAVTVTVGERPVDLDVVLGGAGRLAGSVLTADGAPVRDATVTLTNVHGEVVSTTRSGREGGYVITELVAGEYTLAGSAPAFRPAALPVTVMAARETRQDVELAGGAVLRGTVRAGGGRPVEDARVTLLDAAGNVVDTLTTGADGTFRFVDLSSGEYTVIAAGYPPVATVLHMAGGGRTERDLQLGHED</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K3T2</accession>
    <name>A0A2M9K3T2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_02920</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000001">
        <property type="protein sequence ID" value="PJN13783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN13783">
        <property type="protein sequence ID" value="PJN13783"/>
        <property type="gene ID" value="CG723_02920"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007165">
        <property type="entry name" value="Phage_holin_4_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002591">
        <property type="entry name" value="Phosphodiest/P_Trfase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04020">
        <property type="entry name" value="Phage_holin_4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01663">
        <property type="entry name" value="Phosphodiest"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="SSF53649"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="38"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="67"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="104"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="666"/>
            <end position="693"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN13783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="693" mass="74024" checksum="82CD0354059C8DA4" modified="2018-04-25" version="1">MCWRSIAVWAVSTVTMLVLAGILPDFKLQSDNGDSATRIGVTAALGAGAFAVLSVLVWPLLVRALLLVPALVLGLVVFFLNGGLLLFALAIVPDGRGEANPETAVVVAAVMSAVASATGGALAVRDDDAYRRRLYRLADRRRRRGSAGAGPSTPGTVFLQLDGVGHDVLRDAVNQDVMPTVGAWLGAGTHRLTPWRTDWSSQTGASQLGILHGSNYDVPAFRWYEKDTREVQVSNRPTSAAELQRRAIEHTGDGGLLTLDGASRGNLFSGGAEQVALVLSVAARRGKENRSRAGYFAYFSDPANAVRTALSFVAEVGREIGQSTRARLTRQRPRVGRGGLYPFIRAFATVVERDVVVAAVIGDMLAGRSAVYADLVAYDEVAHHSGPVSRDAEKVLTRLDRSLALIAKVAEHAPRRYRIVVLSDHGQSPGETFRARYGLGLQDLVRAGCGLPVPRRARRTYSGAEARSAVRAALRRPVEEGGEKDRPASRRSEPIVLASGNLGLVSFPDVPHRMSKEEIDARHPALLTTLANHPGIGFLLVRSEEHGAVVLGARGAEIPLADLDDRPGPLADFGVHAADAVRRTDSFPHTADIMVNSWYDPAEGEVLAFEEQIGSHGGLGGAQGHAFLLAPEAFSPPVAEGAELVGAQQVHHVLRRWLREGCGPQVPLDKSRHEPAPDASFTVATVTPQDKSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JEP8</accession>
    <name>A0A2M9JEP8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_45245</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000051">
        <property type="protein sequence ID" value="PJN05376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN05376">
        <property type="protein sequence ID" value="PJN05376"/>
        <property type="gene ID" value="CG723_45245"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="15"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="43"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN05376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="180" mass="18943" checksum="17C69676AB521EE8" modified="2018-04-25" version="1">MPKQHEDEVLRRTSFKVLSCVSTVAFGLVAVGLLVSLTHDLEGGPTSGVAACLFTIALVRRLLGSRIVLDSSAVEIVNPLVTYRVPYSSVAEIRGGGGGTLNLVTRAGDEIYSTGFGGSLIDNFVGSTGRAAERIEQRVRRGRRVTQQGSVTKKFTVSWIADFCTAGAIICAVTAGVLGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-09-29" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JF69</accession>
    <name>A0A2M9JF69_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CG723_44330</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CB01635</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000046">
        <property type="protein sequence ID" value="PJN05546.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN05546">
        <property type="protein sequence ID" value="PJN05546"/>
        <property type="gene ID" value="CG723_44330"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="28"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="66"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="96"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="156"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="234"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="274"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="314"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="339"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="371"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="403"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="31"/>
            <end position="432"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PJN05546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="448" mass="46467" checksum="93E8DFDC3F836D23" modified="2018-04-25" version="1">MAPRPPAPPGTLRSAEAADAPPYDRRRAWLITAVIVAFMVINFADKAVLGLAAVPIMDELDISHSTYGLISSSFSLLFSLSGLVVGLLSSRISSRTLLLVMTLTWTVAQLPVLVLASVPALVAGRLLLGAAEGPAASMSMHALYKWFPAHRRGLPSALQIGGAALGTLVSAPALTWLISQHGWRSAYAALAVASSTWALVWWRVGHDGPFDDARPRASGTTASPGITRLPYRRLLLTGTVLGSISSAFGAAWALSLSQAWLPSYLRTELDMSPGTAATTISAVSALSLVLLLTVSPLMDALKTRGVSSRWSSGATQGIAVCVAGAAMAAFPLINSTLPRLLLIALAFGTVAVAIPLHYMTTAEVVPTAQRGAVFGIVAATGTLPGLVAPSLTGHLIDAADTTASGYTTAFLVAALVMVLAGLLSVASIRPERDALRLGLDHTTAQATR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JFH3</accession>
    <name>A0A2M9JFH3_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CG723_43825</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CB01635</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="NNBL01000044">
        <property type="protein sequence ID" value="PJN05624.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN05624">
        <property type="protein sequence ID" value="PJN05624"/>
        <property type="gene ID" value="CG723_43825"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="8">
        <location>
            <begin position="60"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="318"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="584"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="89"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PJN05624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="918" mass="98433" checksum="DC5C421B4970E81F" modified="2018-04-25" version="1">MARLGTDCCSIRPTNAVAGSRRSQPHGGCRATTLSVSDGARLTKGGALEVSKGTVIAGRYRLAERLGGGGMGEVWKARDQRLRVDVAAKRLILDPHATIEERRTALTYAEKESRHAAALRAHPNVVAVHDVVEDDDGIPWTVMDLVTGRSLAQAVAAGERFEPDHAARIGLQVLGALAAAHAIGITHRDVKPGNIMLADDGSILLVDFGIAKHHADTRITRTGLAVGTVEYMAPERFDGDDGPTGDLWALGVTLYEAVSGISPFRRDSLMATIQAIGRDDLPRPASAGWMAEPIMRLLDKEAHARPTTAQAKALLEDGQDSGTAAPAPEPPAPRPPLSTAQGELFERAIQIAESIRDPDERESALYSVGVSAPSLREEIMPRLSAENRLGLQLELALEAADAVLARRLLDQAGALIALIPDPEEQAASHQQHIIDMSRAAGLLSKVDPAGARQLMEQVESAAHTLPPNPDYTWVLPDQLVEIAKQGRDADPHASRRLINLAEHRALGLDEQEDRNWALGRVSAGVAPVDPDRAERLIGMITERYEQVHSWQESIEAAVSAGCGHVPDLIDAAELALVGPARAAMPTSATPSIPVPTVAAPAQTEERTSGWWRRLRRTRQPDPMDADLEELIEELETEEEEDSTSDLVGIAVAAAAADSSRAERLASRITTHAARAKALTGMAGQVAASDPAQARQWLATAHEAALGIPKGPYSGRPEALGAVAAEAADLDHDLATGVTRHLVSSLGKHVEVWTLVIVAEYIAAVDPAQAVRLVDQAESRTEPLDAGPRRHLALALVTAAVALADTDLQYAKSLVRRAWQAVHRPPEVEEYVELTWWPLRALAVRDLHTAEQLLDQLPSSDQEPLLTHVVSELMESDPRRAEQAAQRITDDTARKQALVQAALAIATNAQGCSSVEEKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JFJ5</accession>
    <name>A0A2M9JFJ5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Mandelate racemase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_44080</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000045">
        <property type="protein sequence ID" value="PJN05583.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN05583">
        <property type="protein sequence ID" value="PJN05583"/>
        <property type="gene ID" value="CG723_44080"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009063">
        <property type="term" value="P:cellular amino acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036849">
        <property type="entry name" value="Enolase-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029017">
        <property type="entry name" value="Enolase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029065">
        <property type="entry name" value="Enolase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018110">
        <property type="entry name" value="Mandel_Rmase/mucon_lact_enz_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013342">
        <property type="entry name" value="Mandelate_racemase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013341">
        <property type="entry name" value="Mandelate_racemase_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13378">
        <property type="entry name" value="MR_MLE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02746">
        <property type="entry name" value="MR_MLE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00922">
        <property type="entry name" value="MR_MLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51604">
        <property type="entry name" value="SSF51604"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54826">
        <property type="entry name" value="SSF54826"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00909">
        <property type="entry name" value="MR_MLE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MR_MLE" evidence="1">
        <location>
            <begin position="165"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN05583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="391" mass="40925" checksum="92F1D387231E157F" modified="2018-04-25" version="1">MVLNPEADTRPATATTVERIEVFTVALPTLREFTVAGGGVTTRGRPAIRVLVKVSASDGSTGWGEATPIPSWTYETTESIVSTLTHYLAPAATGLPLWDLDGLVRACDRAIRRGWSTGMPLARAALDVAWHDALARSRGVSLGELWGRRRHESVELCWIVTGVDADAVADSLAEGRAAGYRHFKVKAGLEPGRGVGADVARVAAVRAAAPDATLIVDANQAGTQESALCLAQRLAPLDVVALEQPLPANDIDGLRRLRDLSPVAIAVDESLRHPTDLASFVRLGAIGIAVAKVQRCAGLTLALRQCQLAEDCGIGLMGSGLTESDIGLAASLHLFAAHDLIAPADLNGRQFLSSPYATGPGIRVRQGVAEVPTGPGLGIGVDEGIVRELAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JG54</accession>
    <name>A0A2M9JG54_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Glutamate dehydrogenase</fullName>
            <ecNumber evidence="2">1.4.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_42290</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>H2O + L-glutamate + NAD(+) = 2-oxoglutarate + H(+) + NADH + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:15133"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.4.1.2"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.4.1.2" evidence="2"/>
    <dbReference type="EMBL" id="NNBL01000039">
        <property type="protein sequence ID" value="PJN05869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN05869">
        <property type="protein sequence ID" value="PJN05869"/>
        <property type="gene ID" value="CG723_42290"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004352">
        <property type="term" value="F:glutamate dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019551">
        <property type="term" value="P:glutamate catabolic process to 2-oxoglutarate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046346">
        <property type="entry name" value="Aminiacid_DH-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028971">
        <property type="entry name" value="NAD-GDH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007780">
        <property type="entry name" value="NAD_Glu_DH_bac"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43403">
        <property type="entry name" value="PTHR43403"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05088">
        <property type="entry name" value="Bac_GDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036761">
        <property type="entry name" value="GDH_Mll4104"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53223">
        <property type="entry name" value="SSF53223"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN05869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="1643" mass="182071" checksum="806D8505D3018BF4" modified="2018-04-25" version="1">MQTKLDEAKAELLARAARVAENSPAGGHLPAGTNGEGAPDQESVLAFLQRYYLHTAPEDLADRDPVDAFGAAVSHYRLAEVRPQGTANVKVHTPTVEENGWTCSHSVVEVVTDDMPFLVDSVTNELSRQGRGIHVVIHPQVTVRRDLTGKLLEVLPAGSAADGHDTLTESWIHVEIDRETDRADLKQITSDLLRVLSDVREAVEDWEKMRDSALRIADDLPSEPTADDLRAQEVEEARELLRWLSTDHFTFLGYREYELREDDSLSAVPGTGLGILRSDPQHGGDDHHPVSPSFSRLPADARAKAREHKILVLTKANSRATVHRPSYLDYVGVKKFDAEGNVIGERRFLGLFSSAAYTESVRRVPVVRRKVQEVLRGAGFSPNSHDGRDLLQILETYPRDELFQTPADELRAIVTSVLYLQERRRLRLYLRQDEYGRYYSALVYLPRDRYTTGVRLRIIDILKEELNGTSVDFTAWNTESILSRLHFVIRVEPGTELPVLTEADTERIEARLVDAARSWADGFGEALNAECGEERAAELGRRYSGAFPEGYKADHSPRAAVADLVHLEALKRGEKDFALSLYEPVGAAPGERRFKIYRTGAPVSLSSVLPVLNRLGVEVIDERPYELRCSDRTTAWIYDFGLRLPKSLSGNGDFLGDDGRERFQEAFTATWTGAAENDGFNSLVLSAGLNWRQAMVLRAYAKYLRQAGATFSQDYMEDTLRNNVHTTRLLVSLFEARMSPERQRAGTELIDGLLEELDGALDQVASLDEDRILRSFLTVIKATLRTNFFQKRDDGTPHAYVSMKFDPQAIPDLPAPRPAYEIWVYSPRVEGVHLRFGKVARGGLRWSDRREDFRTEVLGLVKAQMVKNTVIVPVGAKGGFVAKNLPDPSVDRDAWLAEGVASYKTFISALLDITDNLVAGQVVPPADVVRHDGDDTYLVVAADKGTATFSDIANAVAESYNFWLGDAFASGGSAGYDHKGMGITARGAWESVKRHFRELGTDTQTEDFTVVGVGDMSGDVFGNGMLLSEHIRLVAAFDHRHIFIDPRPDAATSYAERRRLFDLPRSSWADYNKELISAGGGIFPRSAKAIQLNAHIREALGIESGAAKMTPADLMKAILHARVDLLWNGGIGTYVKSSAESNADVGDKANDAIRVDGQDVRAKVIGEGGNLGATQLGRIEFARSGGKVNTDAIDNSAGVDTSDHEVNIKILLNALVTDGDMTIKQRNKLLAEMTDEVGALVLRNNYAQNTALANAVAQAPDLLHAHQRFMRRLVREGSLDRALEFLPTDRQVKELLNSGRGLSQPELAVLLAYTKITAAHELIQTSLPDDPYLRRLLHAYFPQALRERFTDAVDGHALRREIITTVLVNDTVNSGGSTFLHRLREETGASLEEIVRAQLAAREIFGLGEVWDAVESLDNVVAADVQTRIRLHSRRLVERGTRWLLNNRPQPLQLAETIDFFREGVAEVWSAMPKMLRGADAEWYQSILDELTAAGVPEELAQRVAGFSSAFPTLDIVAIADRTGKDPLAVAEVYYDLADRLSIAQLMDRIIELPRSDRWQSMARASIREDLYAAHAALTADVLAAGNGVSTPEQRFDAWQEKNAPILGRARTTLEEIQSSDAFDLANLSVAMRTMRTLLRTHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-09-29" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JHI3</accession>
    <name>A0A2M9JHI3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">FAD-binding monooxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_39915</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000032">
        <property type="protein sequence ID" value="PJN06312.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN06312">
        <property type="protein sequence ID" value="PJN06312"/>
        <property type="gene ID" value="CG723_39915"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD_binding_3" evidence="2">
        <location>
            <begin position="23"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN06312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="427" mass="45925" checksum="784E0812B0063F73" modified="2018-04-25" version="1">MSGQTGRAAQTEQAEPTTPATHRTDVCVVGAGPAGLALSLMLLRSGVRVTLLEKSRAFARDFHGEILQPGGQRILDELGVLAAARSRGDRTLRGFQVLERDRLLLDIDYRRLDAPYDRLLALPQRHLLDALLAACRRLPGFTCLDGHRVKELLQERGRYAGAVASGPGGRRVAVPARVVVAADGRFSKTRALAGIDAGRTEAFDQDVVWFSLPAPGRATGLVRIHRAAGTAVLVHDTYPDRIRVGWTLPHRAWPEVADAGLTAIKNQLAVAVPQFADLIDRHLTSRADLKLLDVFAARAPSWADDGLVLVGDSAHTHGPLGAQGINLALQDAAVLHPVLVEALRAGDVSRARLARFQELRAPAADAVTRVQRLQAKAFLGTSGRVATLARAGAAKLVTRTPIGPRITSRIAHGRVPVHVRTDLFDRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-06-02" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JHM2</accession>
    <name>A0A2M9JHM2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Peptide-N4-asparagine amidase A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_39665</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000031">
        <property type="protein sequence ID" value="PJN06378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN06378">
        <property type="protein sequence ID" value="PJN06378"/>
        <property type="gene ID" value="CG723_39665"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021102">
        <property type="entry name" value="PNGase_A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31104">
        <property type="entry name" value="PTHR31104"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12222">
        <property type="entry name" value="PNGaseA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014805972" evidence="2">
        <location>
            <begin position="21"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="16"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="356"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="362"/>
            <end position="376"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN06378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="546" mass="59057" checksum="0ED3B8A162DF7972" modified="2018-04-25" version="1">MSMLAAVTLAAAALAGQAPAASAEARPAEASADSRPTAPQPADRPTEFGTDWHDPITATPPVAKPATKSCRVALAETEFRDFTPYKGSYTPPKGCGDRWSKVVLRLEGKVKGRQFDRLGYLHIGGVEVLRTSTPEPSPDGIAWNVEKDVTRYSDTLRSDQPVEMLIGNVVDDTYTGVIEVRATLTFYAAEPHVKRQPATDTPDRVLTLDQGRLTTPRNSERIVAEVYATGSGGGCEEFWYLAVPNEVPYSCKADGGPYREVQISVDGQLAGIASPFPNVWTGGWSNPFLWYVIPAPGAFDVRPLQYDLTPFAGLLDDGRPHQVDVSVVGVPKGQSGWSVPVNVLVWQDGGSARVTGALTGHKESEPDSSTTYTPGTDEYRLDAKGGHRLTVSGYVNTSHGRVATTVTRDLTSTSTHRWTEGENNDALKGTWTDRQTVVSGHHTLRTNRAYTMDGATTLDADNRLRTVIDLGDRAATGRATGSGRTAWTVLDDTYAGDASYTANVPRDQRHAVGASRERYRLTSPDGCYDRELATAQGALTVDRRRC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JHY0</accession>
    <name>A0A2M9JHY0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CG723_38770</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000029">
        <property type="protein sequence ID" value="PJN06489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN06489">
        <property type="protein sequence ID" value="PJN06489"/>
        <property type="gene ID" value="CG723_38770"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PJN06489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="82" mass="8832" checksum="0A6869F19B033EB2" modified="2018-04-25" version="1">MRRTHPDLFLRLCGNALTAPPDDGGRGEWITVHLGYGEVHEARSLLSFAVHVQVVEPPEIRAELGRCGATITAVYGPPTGTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JIQ4</accession>
    <name>A0A2M9JIQ4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Sodium:proton antiporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CG723_37295</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CB01635</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000026">
        <property type="protein sequence ID" value="PJN06740.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN06740">
        <property type="protein sequence ID" value="PJN06740"/>
        <property type="gene ID" value="CG723_37295"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015293">
        <property type="term" value="F:symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3860.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001991">
        <property type="entry name" value="Na-dicarboxylate_symporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036458">
        <property type="entry name" value="Na:dicarbo_symporter_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42865">
        <property type="entry name" value="PTHR42865"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00375">
        <property type="entry name" value="SDF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF118215">
        <property type="entry name" value="SSF118215"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="59"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="95"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="160"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="199"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="229"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="341"/>
            <end position="358"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PJN06740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="448" mass="47499" checksum="3DF9AB243B38E528" modified="2018-04-25" version="1">MSANTASASEKQKPRFRIPIPFWAQVLLGLVVGLVLGYVARTYDVSWLATTLDKVGGIFIQLLKLAVAPLVFFAILVSITNLRKVNNAARLASRTLLWFMITSLIAVVIGLAIGLITNPGNGSNLTPADGSKPDHAGSWLDFLTGIVPTDVVTPFTELNVLQIVFMAVVAGVAILKIGPKAQPILSLSESVLELLQKALWWVILLAPIGSAGLIGRAIVQYGWDLLGNYATFTIDIYVGCALVLFGVYPLLLATVAKLNPLQFFKGAWPAIQLAFVSRSSVGTMPVTQQSAERLGVPRNYASFAVPFGATTKMDGCAAIYPAISAIFVAQIFDVQLGIKEYLLIAFVSVIGSAATAGLTGATVMLTLTLSTLGLPMEGVGLLLAIDPILDMMRTATNVAGQALVPVIVAARENILDRVKYDNATASPVEELVVESRHEDEPQAVGAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JIT6</accession>
    <name>A0A2M9JIT6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">2-oxoglutarate ferredoxin oxidoreductase subunit alpha</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CG723_37600</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000026">
        <property type="protein sequence ID" value="PJN06791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN06791">
        <property type="protein sequence ID" value="PJN06791"/>
        <property type="gene ID" value="CG723_37600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016903">
        <property type="term" value="F:oxidoreductase activity, acting on the aldehyde or oxo group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07034">
        <property type="entry name" value="TPP_PYR_PFOR_IOR-alpha_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.920.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022367">
        <property type="entry name" value="2-oxoacid/accept_OxRdtase_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033412">
        <property type="entry name" value="PFOR_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019752">
        <property type="entry name" value="Pyrv/ketoisovalerate_OxRed_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002880">
        <property type="entry name" value="Pyrv_Fd/Flavodoxin_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002869">
        <property type="entry name" value="Pyrv_flavodox_OxRed_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009014">
        <property type="entry name" value="Transketo_C/PFOR_II"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17147">
        <property type="entry name" value="PFOR_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01558">
        <property type="entry name" value="POR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01855">
        <property type="entry name" value="POR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52922">
        <property type="entry name" value="SSF52922"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53323">
        <property type="entry name" value="SSF53323"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03710">
        <property type="entry name" value="OAFO_sf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="POR" evidence="3">
        <location>
            <begin position="43"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="domain" description="POR_N" evidence="4">
        <location>
            <begin position="286"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="domain" description="PFOR_II" evidence="5">
        <location>
            <begin position="542"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01558"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01855"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF17147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PJN06791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="643" mass="69288" checksum="B97BB8E51CA873D2" modified="2018-04-25" version="1">MTSQVSSPAEQADGAVVREQRRHANDKDVRRLDRVIIRFAGDSGDGMQLTGDRFTSETASFGNDLSTLPNFPAEIRAPAGTLPGVSSFQLHFADHDILTPGDAPNVLVAMNPAALKANIADVPRGAEIIVNTDEFTKRAMQKVGYETSPLEDGSLDGYHVHPVPLTTLTVEALKEFGLSRKDAGRSKNMFALGLLSWMYHRPTEGTERFLKSKFAKKPQIAAANIAAFHAGWNFGETTEDFAVSYEVAPASSAFPTGTYRNISGNLALSYGLIAASRQADLPLYLGSYPITPASDILHELSKHKNFGVRTFQAEDEIAGIGAALGASFGGSLAVTTTSGPGVALKSETIGLAVSLELPLLVVDIQRGGPSTGLPTKTEQADLLQAMYGRNGEAPVPVVAPRTPADCFDAAIEAARIAITYRTPVFLLSDGYLANGSEPWRIPEIDQLPDLRTQFASGPNHTEDDGTEAFWPYKRDPQTLARPWAIPGTPGLEHRIGGIEKQDGTGNISYDPANHELMVRTRQAKIDGIEVPDLEVDDASGEANTLVLGWGSTYGPITAAVRRLRTAGEHIAQAHLRHLNPFPRNLGEVLKRYEKVVIPEMNLGQLATLVRAKYLVDAHSHNQVNGMPFKAEQLATALKEAIHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JIV2</accession>
    <name>A0A2M9JIV2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Large conductance mechanosensitive channel protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CG723_37670</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CB01635</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000026">
        <property type="protein sequence ID" value="PJN06804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN06804">
        <property type="protein sequence ID" value="PJN06804"/>
        <property type="gene ID" value="CG723_37670"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037673">
        <property type="entry name" value="MSC/AndL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036019">
        <property type="entry name" value="MscL_channel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30266">
        <property type="entry name" value="PTHR30266"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01741">
        <property type="entry name" value="MscL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81330">
        <property type="entry name" value="SSF81330"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="70"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PJN06804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="151" mass="16105" checksum="E668C23BBCFE1A68" modified="2018-04-25" version="1">MLSGFKDFILRGNIVTMAIGLAVGSAFTAVVTGFSTAFIAPLIGLATSSTGDFSKAHFQVEGTDFPYGKFVSAAIAFVITAAVLYFLVVVPMMKLQTRLDRGKPVDLKATLRDCPRCFSQIPAIATRCSHCTSELKADPEVLALAGLPEQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JJ17</accession>
    <name>A0A2M9JJ17_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Histidine kinase</fullName>
            <ecNumber evidence="3">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CG723_36990</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CB01635</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="3"/>
    <dbReference type="EMBL" id="NNBL01000025">
        <property type="protein sequence ID" value="PJN06876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN06876">
        <property type="protein sequence ID" value="PJN06876"/>
        <property type="gene ID" value="CG723_36990"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040868">
        <property type="entry name" value="DraK_HK_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18092">
        <property type="entry name" value="DraK_HK_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="125"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="9">
        <location>
            <begin position="149"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="8">
        <location>
            <begin position="209"/>
            <end position="410"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PJN06876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="424" mass="45513" checksum="6A3654AF9BC731B3" modified="2018-04-25" version="1">MRRRLINSTLAVVLVVIAVFGVSLVIVETRTITNSAQERVDSEAVRLVSIVDSRLLGDEQVTGAILRNQVGPDRYARIELPGRAPIEIGERPRGDVIQATAKGEKGETVTVEEPRSSVTREVGRTLLIIAGVALLAVIAAVLLAVRQANRLTSPLTDLASTAERLGSGDPRPRHRRYGVAELDRVADVLDSSAERIARMLTAERRLAADASHQLRTPLTALSMRLEEITVTDDLDTVKEEATIALAQVERLTDVVERLLTNSRDPRTGSAVSFDLDEVIKQQLEEWRPAYRSAGRAIVSSGKRHLKAVGTPGAVAQVLAALIENSLMHGGGTVALRTRVTGNQAVVEVTDEGPGVPGDLGARIFERTISGRNSTGIGLAVARDLAEADGGRLEMLQTNPPVFGLFLSRTPLKKSAPGEGTETVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JJ62</accession>
    <name>A0A2M9JJ62_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">B/F/G family RNA polymerase sigma-70 factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CG723_36940</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000025">
        <property type="protein sequence ID" value="PJN06915.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN06915">
        <property type="protein sequence ID" value="PJN06915"/>
        <property type="gene ID" value="CG723_36940"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014322">
        <property type="entry name" value="RNA_pol_sigma-B/F/G"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000943">
        <property type="entry name" value="RNA_pol_sigma70"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007624">
        <property type="entry name" value="RNA_pol_sigma70_r3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007630">
        <property type="entry name" value="RNA_pol_sigma70_r4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04539">
        <property type="entry name" value="Sigma70_r3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04545">
        <property type="entry name" value="Sigma70_r4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00046">
        <property type="entry name" value="SIGMA70FCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02980">
        <property type="entry name" value="SigBFG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00715">
        <property type="entry name" value="SIGMA70_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0731">Sigma factor</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="RNA_pol_sigma70" evidence="6">
        <location>
            <begin position="97"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS00715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PJN06915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="294" mass="32903" checksum="2145588F02C71559" modified="2018-04-25" version="1">MSPRLDESRTDQASTSTPPPEHEAFDNLAGLPEIPPFDEVAPRDARALSKTLFGRLESLEEGTHEYSYVRNTLVELNLALVKFAASRFRSRSEPMEDIIQVGTIGLIKAIDRFELSRGVEFPTFAMPTIVGEIKRFFRDTSWSVRVPRRLQELRLDLAKAGDELAQQFDRAPTVGELAERLGITNDEVVEGMAASNAYTASSLDAQPEEDDSEGALADRIGYEDHELEGIEYVESLKPLIAELPSRDRKILSLRFVANMTQSEIGDELGISQMHVSRLLSRTLVRLRKGLTLEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JJM1</accession>
    <name>A0A2M9JJM1_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">UPF0145 protein CG723_35625</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_35625</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the UPF0145 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000023">
        <property type="protein sequence ID" value="PJN07064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN07064">
        <property type="protein sequence ID" value="PJN07064"/>
        <property type="gene ID" value="CG723_35625"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00338">
        <property type="entry name" value="UPF0145"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002765">
        <property type="entry name" value="UPF0145"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035439">
        <property type="entry name" value="UPF0145_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34068">
        <property type="entry name" value="PTHR34068"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01906">
        <property type="entry name" value="YbjQ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117782">
        <property type="entry name" value="SSF117782"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010751"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00338"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN07064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="121" mass="12898" checksum="7A2E65A3E7BB570F" modified="2018-04-25" version="1">MGIEDYGGGQNPQTDVLVVTTNDVPGYRVEKVIGEVFGLTVRSRHLGSQIGAGLKSMIGGELKGLTKTLVETRNQAMERLVEQARSRGANGVLMFRFDVTEAADVGTEVCAYGTAVVIAPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JJQ6</accession>
    <name>A0A2M9JJQ6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">TetR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_35860</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000023">
        <property type="protein sequence ID" value="PJN07106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN07106">
        <property type="protein sequence ID" value="PJN07106"/>
        <property type="gene ID" value="CG723_35860"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023772">
        <property type="entry name" value="DNA-bd_HTH_TetR-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01081">
        <property type="entry name" value="HTH_TETR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="9"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="32"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN07106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="190" mass="21862" checksum="9439D90FE695E309" modified="2018-04-25" version="1">MGSSKQRRGNTRQRIQDVALELFAEQGYEKTSLREIAEHLDVTKAALYYHFKTKEDIVVSLFEDLTRPIDELIEWGREQPNTLETKQELMERYSLALHGAGPLFRFMQENQATMRELSIGELFKDRMKALLDQLLPEDATLTERVRCFSAIFSMHAGLFVLKDVEGDPEEKRKAILEVATDLITQAQRGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JJR6</accession>
    <name>A0A2M9JJR6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">NDP-hexose 4-ketoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CG723_35845</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000023">
        <property type="protein sequence ID" value="PJN07104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN07104">
        <property type="protein sequence ID" value="PJN07104"/>
        <property type="gene ID" value="CG723_35845"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1780.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019489">
        <property type="entry name" value="Clp_ATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036628">
        <property type="entry name" value="Clp_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004176">
        <property type="entry name" value="Clp_R_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001270">
        <property type="entry name" value="ClpA/B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018368">
        <property type="entry name" value="ClpA/B_CS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041546">
        <property type="entry name" value="ClpA/ClpB_AAA_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001943">
        <property type="entry name" value="UVR_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07724">
        <property type="entry name" value="AAA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17871">
        <property type="entry name" value="AAA_lid_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02861">
        <property type="entry name" value="Clp_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10431">
        <property type="entry name" value="ClpB_D2-small"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00300">
        <property type="entry name" value="CLPPROTEASEA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01086">
        <property type="entry name" value="ClpB_D2-small"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81923">
        <property type="entry name" value="SSF81923"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51903">
        <property type="entry name" value="CLP_R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00870">
        <property type="entry name" value="CLPAB_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50151">
        <property type="entry name" value="UVR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0143">Chaperone</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 5" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Clp R" evidence="8">
        <location>
            <begin position="2"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="domain" description="UVR" evidence="7">
        <location>
            <begin position="422"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="815"/>
            <end position="842"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PJN07104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="842" mass="92999" checksum="F74A6348D691152A" modified="2018-04-25" version="1">MFERFTDRARRVVVLAQEEARMLNHNYIGTEHILLGLIHEGEGVAAKALESLGISLEAVRQQVEEIIGQGQQAPSGHIPFTPRAKKVLELSLREALQLGHNYIGTEHILLGLIREGEGVAAQVLVKLGADLNRVRQQVIQLLSGYQGKETAGASGGPAEGTPSTSLVLDQFGRNLTQAARESKLDPVIGREKEIERVMQVLSRRTKNNPVLIGEPGVGKTAVVEGLAQAIVKGEVPETLKDKHLYTLDLGALVAGSRYRGDFEERLKKVLKEIRTRGDIILFIDELHTLVGAGAAEGAIDAASILKPMLARGELQTIGATTLDEYRKHLEKDAALERRFQPIQVAEPSLPHTIEILKGLRDRYEAHHRVSITDEALVQAATLADRYISDRFLPDKAIDLIDEAGSRMRIRRMTAPPDLREFDEKIAGVRRDKESAIDSQDFEKAASLRDKEKQLLAGKAKREKEWKAGDMDVVAEVDGDLIAEVLATATGIPVFKLTEEESSRLLRMEDELHKRVIGQKDAVKALSKAIRRTRAGLKDPKRPGGSFIFAGPSGVGKTELSKALAEFLFGDEDALISLDMSEFSEKHTVSRLFGSPPGYVGYEEGGQLTEKVRRKPFSVVLFDEVEKAHPDIFNSLLQILEDGRLTDSQGRVVDFKNTVIIMTTNLGTRDISKGFNLGFAATGDTKSNYERMKNKVSDELKQHFRPEFLNRVDDVVVFPQLTQDDILQIVDLMIGKVDERLKDRDMGIELSQSAKELLAKKGYDPVLGARPLRRTIQREIEDSLSEKILFGELRPGHIVVVDTEGEGDAKTFTFRGEEKATLPDVPPIEQAAGGAGPNLNKEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JKQ8</accession>
    <name>A0A2M9JKQ8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Gluconate 5-dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CG723_33735</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000020">
        <property type="protein sequence ID" value="PJN07460.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN07460">
        <property type="protein sequence ID" value="PJN07460"/>
        <property type="gene ID" value="CG723_33735"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PJN07460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="256" mass="25317" checksum="439FB6D0447C4A80" modified="2018-04-25" version="1">MTPTTSTSPTTTTGPVLVTGGTSGIGLAVAEAVARSGRPAVVIGRTADRCHAAEIGLKATGGPHLAVVADTTGPDALAAVVARAADRWGPVTGLVTCAGRLARGSVLDLPTAELRAALETNVVGTWLAIRAVLPGMLDAGFGRIVTVGSVLGSTGAPERAGYAATKGAVASLTRSAALELAGTGVTVNCVAPGPVRTPMNADDTDEAADAAFTAKVPLGRWGRPEDIAHAVLPLLAPGSAFTTGTVVHVDGGYTAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JKR4</accession>
    <name>A0A2M9JKR4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Nitrate ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CG723_33765</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000020">
        <property type="protein sequence ID" value="PJN07465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN07465">
        <property type="protein sequence ID" value="PJN07465"/>
        <property type="gene ID" value="CG723_33765"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="25"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="57"/>
            <end position="64"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PJN07465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="284" mass="30735" checksum="929A436B6CADD559" modified="2018-04-25" version="1">MTRTTEPQQPSKEAELLGHGRGAALHAEGVGIHFDAFQAVRGIDLDIAAGEFLCLLGPSGCGKSTLLSAMAGFVPVSEGALTVDGAPITGPGPELGMVFQSSEALFDWATVRQNVAFGPRMRGRSRTEQARLADEFLALVGLRHCADRFPGQLSGGMRQRVQIARVLANEPQVVLMDEPFGALDAQTRQVLQQETDRIWRSSGCTVVFVTHDIDEAILLADRVAVMTAGPAAAIKSVYEVDLPRPRDETEPAAIELRRQLRDDIGEEVRKALRDQGLDPEEATR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JKS4</accession>
    <name>A0A2M9JKS4_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PAS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_33830</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000020">
        <property type="protein sequence ID" value="PJN07475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN07475">
        <property type="protein sequence ID" value="PJN07475"/>
        <property type="gene ID" value="CG723_33830"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013767">
        <property type="entry name" value="PAS_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13185">
        <property type="entry name" value="GAF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13581">
        <property type="entry name" value="HATPase_c_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00989">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07228">
        <property type="entry name" value="SpoIIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00065">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00331">
        <property type="entry name" value="PP2C_SIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PAS" evidence="1">
        <location>
            <begin position="27"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN07475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="776" mass="82911" checksum="8586D4BD517D7B0A" modified="2018-04-25" version="1">MEVARMCVPKRRCAMPASAVLMRIADDGRILEWSAQARELLGWSRADAEGRTVAGLVRPGSPASEVVAALAALGEVSVRPALSGGSLTWEVSAAEGSGSTERDIAVLQALFADAPMDLYVLDCDLRIVRSRARTPEAQPAVKETQAGPDFASTLGLEDPANERAVARLVLASGEPALQRVVRSAGAEGTSRPVVYSLSYVRVEGRDGRTQCLVASAMDVTDRERTLRRLKVLERVRTTVGDRLDVMSVCQELVEAVVPTFSGIVVVEVIEDVFRGQEPPLAPVAYDVPLRRAAFKGLVSAHAVGDVRRLPDGTPFSRVLNDLRPRLLSVAEDSPWLSADPARANSIVRSDAHSLIVAPLTVRGEALGVVSFYRHGDEEPFDEHDVTLTTDVCAHAALCIDNARRYTRERTIAATVKRQLLPQKSPVPSTVDVATMHIPGPGGGGAWFDTIELAGGRVALVLGDVAGRGVATATTMGQLRTVIHALAALDLEPQELMARLSDTAERLATERAALPAGDPLNSEPLTAACLIAIYDSVDHTCTLVRAGLSEPYLVLPDGESATVTTPGGPVLAGTDHAPFPATEITMPAGSTLAVGNEDLLETSPTLRVLLREGATLPLTEVCDTLSYALRDRHDTEKMLLLARARGLPPDRVLTVALAEDLAAVPAARKAARRQLAAWKISEESAFTTELIVSELVANAVRYGAPPYRLRLILDDRLTCEIRDAGTSVPHLKHARAIDEGGRGLFIVASITDAWGVRYHVQGKTVWAQQGTVAAEPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JL00</accession>
    <name>A0A2M9JL00_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Serine hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CG723_33990</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000020">
        <property type="protein sequence ID" value="PJN07532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN07532">
        <property type="protein sequence ID" value="PJN07532"/>
        <property type="gene ID" value="CG723_33990"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001466">
        <property type="entry name" value="Beta-lactam-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008757">
        <property type="entry name" value="Peptidase_M6-like_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00144">
        <property type="entry name" value="Beta-lactamase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05547">
        <property type="entry name" value="Peptidase_M6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014987163" evidence="2">
        <location>
            <begin position="32"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-lactamase" evidence="3">
        <location>
            <begin position="74"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M6" evidence="4">
        <location>
            <begin position="428"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="30"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF05547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PJN07532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="593" mass="63863" checksum="62E4505E9728F350" modified="2018-04-25" version="1">MSMSRRQLGAGVLALGGALAIAPFPAGPASAADTHTAGQADGHGTTLRRGSPERAGLIAGHLRQLVADAEKFLAPSPKHPWYAGAVLLAGRGGTVALHQPIGKAVRYSAYDDKTDTGVEFPADQQIAAAEDTVYDLASVSKLFTSLIAVQEIERGRLELEATVASYIPDFAGAGKQDITIRQLLTHTSGFRAWIPLYKETTREGQLRLIWNEAPLNPPGTVYLYSDLNLISLQLVLEKLTGRTLDVLLHERITGPLGMRRTRYNPPASWKPKIAATEDARLPWSGLDRGLVWGEVHDENAFGLGGVAGHAGVFSCAWDLAILGRTLLNGGSYGKARILSEESVRLLFTDFNQAFPGDEHGLGFELYQHWYMGAMATPRTAGHTGFTGTSIVLDPTTDSFLIVLGNSVHPVRTWRSGSAPRVATANNLARAVAVRPAHGRTAWFSGMTSATSATLTLPGLDVTSDAASLACDLWWDTEPHSDFLYLEASADAGATWQALPFATTRKGEDADDHSKGTADGWSGRAWHRLTAALGAFKGSQVRLRWRYATDQLYVGRGVYVNGVRVTEGRRTVFDEARPSDAARIEAVGWSPSQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JL06</accession>
    <name>A0A2M9JL06_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NADPH:quinone reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_33720</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000020">
        <property type="protein sequence ID" value="PJN07457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN07457">
        <property type="protein sequence ID" value="PJN07457"/>
        <property type="gene ID" value="CG723_33720"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="PKS_ER"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PKS_ER" evidence="1">
        <location>
            <begin position="10"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN07457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="315" mass="32563" checksum="5235EE2325EF2306" modified="2018-04-25" version="1">MRAARIHAWGAAPVVEEVPEPVRGEGEVLVQVEAGGIGHLDATIASGEFAMKPTPPYIGGVEGAGTVLEADADSGLAPGTQVVLRGTGLGMLRDGTWTERISVRRKAVTPLEAPLEPAVAASFFVPATTAYVALHDVGRVEKGEEVVVVGAAGAVGAMVAQQALAAGARVTGVVGRADQLADVPEGVEAVQLADAEALGKDRAASLLVDTLGGEGLLGRSRWVRQGGRAVVIGYVAGPRAELDLPSWLLDEVALLPVNMIRAERRAREVSPDLVRRLSQGELTLAVEKFALDDIPSALDALKAGRVRGRAVALPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JL95</accession>
    <name>A0A2M9JL95_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Protein phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CG723_33360</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000019">
        <property type="protein sequence ID" value="PJN07650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN07650">
        <property type="protein sequence ID" value="PJN07650"/>
        <property type="gene ID" value="CG723_33360"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006470">
        <property type="term" value="P:protein dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00143">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015655">
        <property type="entry name" value="PP2C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13832">
        <property type="entry name" value="PTHR13832"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00481">
        <property type="entry name" value="PP2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00331">
        <property type="entry name" value="PP2C_SIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00332">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="SSF81606"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51746">
        <property type="entry name" value="PPM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="356"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="domain" description="PPM-type phosphatase" evidence="3">
        <location>
            <begin position="21"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="283"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="454"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="471"/>
            <end position="521"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PJN07650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="535" mass="56649" checksum="CD33B550777E207F" modified="2018-04-25" version="1">MGTVRMYPEPTGEVRMSLSLRFAAGSHKGMIREGNEDSGYAGPRLLAIADGMGGQAAGEVASSEVISTIVALDDDVPGSDILTSLGTAVQRANDQLRMMVEEDPQLEGMGTTLTALLWTGQRLGLVHVGDSRAYLLRDGVLTQITQDHTWVQRLVDEGRITEEEATTHPQRSLLMRALGSGDHVEPDLSIREVRAGDRYLICSDGLSGVVSHQTMEETLASYQGPQETVQDLIQLALRGGGPDNITVIVADVLDIDSGDTLAGQLSDAPVIVGAVAENQQHQLHDGGAMQTPAGRASELGRGSGRPVPGQGGGGGEFGPPGSGDAAGYAPEGSFGSYGDDDFVKPRRGRKWLKRSFFIALALAVVGGGLYGGYRWTQTQYYVGSNESHVALYRGISQDLAWVSLSEVEKDHPEIELKYLPPYQRKQVEATITEGSFGDAKDKIGELSLQASACRKDAERRQAENEQNAKTGEGEAGGTTGATKTSFTTSRTSAKTAPSPTPTPSGTAKSKTAPTPTPGPSLSEDEQKLVPLCGKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-09-29" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JLF7</accession>
    <name>A0A2M9JLF7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Disulfide bond formation protein DsbA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_32025</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000018">
        <property type="protein sequence ID" value="PJN07705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN07705">
        <property type="protein sequence ID" value="PJN07705"/>
        <property type="gene ID" value="CG723_32025"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012336">
        <property type="entry name" value="Thioredoxin-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13462">
        <property type="entry name" value="Thioredoxin_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="2">
        <location>
            <begin position="1"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN07705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="185" mass="20191" checksum="4C844A17A508DEFC" modified="2018-04-25" version="1">MGSPAPDWKTGRMNDASPASAPQGRPVLDVWCELQCPDCRTALDDVRALRARYGDRIDLRLRHFPLEKHKHAFAGAQAAEEAFEQGQGWPYVEAVLGRVEELGRKGEPFLVEVAGELGLDAEEFDTALVDGRHILIVDADQAEGKAIGVTGTPTYVIDGERLDGGKSQDGLRERVEEIADRLLGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-06-02" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JLI9</accession>
    <name>A0A2M9JLI9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_33280</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000019">
        <property type="protein sequence ID" value="PJN07637.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN07637">
        <property type="protein sequence ID" value="PJN07637"/>
        <property type="gene ID" value="CG723_33280"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="99"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="104"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN07637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="182" mass="19322" checksum="299C07701C7677C9" modified="2018-04-25" version="1">MDAAQQEATARARELQRNWYGEPLGALFRRLIDDLGLNQARLAGVLGLSAPMLSQLMSGQRAKIGNPAVVQRVQLLQDLAGQVADGSVSAAEATERMDEIKKSQGGSVLTNTAQTTTSSGAPTVKRVVREIQSLLRSVSAAGDIIDAADTLAPSHPELAEFLRVYGAGRTSDAVTHYQAHQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JLP7</accession>
    <name>A0A2M9JLP7_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Pup--protein ligase</fullName>
            <ecNumber evidence="2">6.3.1.19</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Proteasome accessory factor A</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="2">Pup-conjugating enzyme</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2 4" type="primary">pafA</name>
        <name evidence="4" type="ORF">CG723_32570</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CB01635</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>ATP + [prokaryotic ubiquitin-like protein]-L-glutamate + [protein]-L-lysine = ADP + phosphate + N(6)-([prokaryotic ubiquitin-like protein]-gamma-L-glutamyl)-[protein]-L-lysine.</text>
            <dbReference type="EC" id="6.3.1.19"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein degradation; proteasomal Pup-dependent pathway.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein pupylation.</text>
    </comment>
    <comment type="miscellaneous">
        <text evidence="2">The reaction mechanism probably proceeds via the activation of Pup by phosphorylation of its C-terminal glutamate, which is then subject to nucleophilic attack by the substrate lysine, resulting in an isopeptide bond and the release of phosphate as a good leaving group.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Pup ligase/Pup deamidase family. Pup-conjugating enzyme subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.1.19" evidence="2"/>
    <dbReference type="EMBL" id="NNBL01000018">
        <property type="protein sequence ID" value="PJN07800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN07800">
        <property type="protein sequence ID" value="PJN07800"/>
        <property type="gene ID" value="CG723_32570"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00997"/>
    <dbReference type="UniPathway" id="UPA00998"/>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016879">
        <property type="term" value="F:ligase activity, forming carbon-nitrogen bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019787">
        <property type="term" value="F:ubiquitin-like protein transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019941">
        <property type="term" value="P:modification-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010498">
        <property type="term" value="P:proteasomal protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070490">
        <property type="term" value="P:protein pupylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02111">
        <property type="entry name" value="Pup_ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022279">
        <property type="entry name" value="Pup_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004347">
        <property type="entry name" value="Pup_ligase/deamidase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42307">
        <property type="entry name" value="PTHR42307"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03136">
        <property type="entry name" value="Pup_ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF018077">
        <property type="entry name" value="UCP018077"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03686">
        <property type="entry name" value="pupylate_PafA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 4" id="KW-0436">Ligase</keyword>
    <keyword evidence="2" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="active site" description="Proton acceptor" evidence="2 3">
        <location>
            <position position="57"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="9"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="53"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="55"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="63"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="66"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="420"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR018077-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PJN07800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="453" mass="52128" checksum="746788241C270C13" modified="2018-04-25" version="1">MDRRIFGLENEYGVTCTFRGQRRLSPDEVARYLFRRVVSWGRSSNVFLRNGARLYLDVGSHPEYATPECDNVTELVTHDKAGERILEGLLVDAERRLHEEGIAGDVYLFKNNTDSAGNSYGCHENYLVARHGEFSRLADILIPFLVTRQLLCGAGKVLQTPRGAVYCVSQRAEHIWEGVSSATTRSRPIINTRDEPHADAERYRRLHVIVGDSNMSETTMLLKVGATDLVLRMIEAGTVMRDLTLENPIRAIREVSHDITGQRKVRLASGREASALEVQREYYEKAVDFCERRGIRTGTVEQVLELWGRVLDSIEAEDLDRIGTEIDWVMKYKLIERYRAKHNMTMSHPRVAQIDLAYHDIHRRRGLYYLLERKGQAARICNDLKIFEGKSVPPQTTRARLRGDFIRRAQEQRRDFTVDWVHLKLNDQAQRTVLCKDPFRSVDDRVEKLIAGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JLQ6</accession>
    <name>A0A2M9JLQ6_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Sec-independent protein translocase protein TatC</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5 7" type="primary">tatC</name>
        <name evidence="7" type="ORF">CG723_32530</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CB01635</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">The Tat system comprises two distinct complexes: a TatABC complex, containing multiple copies of TatA, TatB and TatC subunits, and a separate TatA complex, containing only TatA subunits. Substrates initially bind to the TatABC complex, which probably triggers association of the separate TatA complex to form the active translocon.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the TatC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000018">
        <property type="protein sequence ID" value="PJN07792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN07792">
        <property type="protein sequence ID" value="PJN07792"/>
        <property type="gene ID" value="CG723_32530"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033281">
        <property type="term" value="C:TAT protein transport complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008320">
        <property type="term" value="F:protein transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043953">
        <property type="term" value="P:protein transport by the Tat complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00902">
        <property type="entry name" value="TatC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002033">
        <property type="entry name" value="TatC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30371">
        <property type="entry name" value="PTHR30371"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00902">
        <property type="entry name" value="TatC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01840">
        <property type="entry name" value="TATCFAMILY"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00945">
        <property type="entry name" value="tatC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0811">Translocation</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="29"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="98"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="134"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="184"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="217"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="241"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="272"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="299"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PJN07792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="314" mass="34577" checksum="784F32B550476202" modified="2018-04-25" version="1">MLKSARKTEKDPEGRMPLAEHLRELRNRLTKALLAIVVVTIVAAFFYKDIIEFFTNPVLDSVGCKSSFAELAEQANKGQHDETCARIVLNGLLTPFTLALKISLMAGVVLASPVWLYQLWGFVAPGLHRHEKKYATAFVATGFPLFLCGAFFAYKTLPTMARVLLDFSPGGVDNQLPLDDLLDLITRMVVVFGLSFELPLLLVMLNLTGVITGKRMIGWWRGMIMGITVFAAVATPSTDPLSMLALAGPIWVLYFAAAGFSLLNDRRKARDREDLDDDEASNVDLTPEPVSASRALPEQASSDHDRVNGYDDVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JLY3</accession>
    <name>A0A2M9JLY3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Four-helix bundle copper-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CG723_31360</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000017">
        <property type="protein sequence ID" value="PJN07891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN07891">
        <property type="protein sequence ID" value="PJN07891"/>
        <property type="gene ID" value="CG723_31360"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd08026">
        <property type="entry name" value="DUF326"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044543">
        <property type="entry name" value="YHJQ-like"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PJN07891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="120" mass="13194" checksum="F097D207AAB9A982" modified="2018-04-25" version="1">MTQAGSMTAMSKEMQDCVAACMSCHSVCEETMSSCMQMGGQPQMQIMRALIDCSEMTRMCADMMMRRSPMSPEMCAMCAKACDMCAEACMSMPDDQQMMRCAEACRRSAEMCRAMAGATM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JMS1</accession>
    <name>A0A2M9JMS1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CG723_29635</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CB01635</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000015">
        <property type="protein sequence ID" value="PJN08170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08170">
        <property type="protein sequence ID" value="PJN08170"/>
        <property type="gene ID" value="CG723_29635"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045621">
        <property type="entry name" value="BPD_transp_1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19300">
        <property type="entry name" value="BPD_transp_1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="9"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="108"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="145"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="188"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="247"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="292"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="106"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PJN08170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="325" mass="35961" checksum="3AAEB0E97C109879" modified="2018-04-25" version="1">MLQFLFRRLTGAVVIMILIAAFTFFLFYTVPQDFAELACGKNCSPQNIAVIRENLGLDKSIAAQFWEFMRGIVMGRDFPVGHCPAPCLGMSFKSNDFVWDSIVDRFPLTLSLTIGGLVVFLVVGLGTGLLAAWKRGTVLDRLVSGASIVLSSFQIYLLGPIVLGLFVYSTGWMDNPKYVPFFDSPTKWFLGLLIPWVVMATIFTAQYTRMARSTMIEQLQEEHVRTAKAKGMGGKYVFFRYAWRGSLIPIVTILGIDLSGLLAGAVVTEYTFDLPGLGRLAVESSTDKDLPLTMGAMLVGAFFILILNIIVDIAYAYIDPRVRLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JMV2</accession>
    <name>A0A2M9JMV2_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Sec-independent protein translocase protein TatB</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">tatB</name>
        <name evidence="10" type="ORF">CG723_29810</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CB01635</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatC, TatB is part of a receptor directly interacting with Tat signal peptides. TatB may form an oligomeric binding site that transiently accommodates folded Tat precursor proteins before their translocation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">The Tat system comprises two distinct complexes: a TatABC complex, containing multiple copies of TatA, TatB and TatC subunits, and a separate TatA complex, containing only TatA subunits. Substrates initially bind to the TatABC complex, which probably triggers association of the separate TatA complex to form the active translocon.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell membrane</location>
            <topology evidence="8">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the TatB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000015">
        <property type="protein sequence ID" value="PJN08202.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08202">
        <property type="protein sequence ID" value="PJN08202"/>
        <property type="gene ID" value="CG723_29810"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033281">
        <property type="term" value="C:TAT protein transport complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008320">
        <property type="term" value="F:protein transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043953">
        <property type="term" value="P:protein transport by the Tat complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00237">
        <property type="entry name" value="TatB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003369">
        <property type="entry name" value="TatA/B/E"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018448">
        <property type="entry name" value="TatB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02416">
        <property type="entry name" value="TatA_B_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 8" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 8" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 8" id="KW-0811">Translocation</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1 8" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="102"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="104"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="129"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PJN08202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="150" mass="16536" checksum="3DD663E3FDDB68A1" modified="2018-04-25" version="1">MFNDIGPLELLTLVVLAVLVFGPDKLPKVIQDVTRTIRKIREFSDSAKRDIREELGPEFKDFEFEDLNPKTFLRKQLDNDELGLKEIRNGFDLKKEMAEVTEAVQSADESSSGSGAAAASSGSAPAKIDMQKKPEKPAADDHPPYDADAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JN19</accession>
    <name>A0A2M9JN19_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_29950</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000015">
        <property type="protein sequence ID" value="PJN08268.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08268">
        <property type="protein sequence ID" value="PJN08268"/>
        <property type="gene ID" value="CG723_29950"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="74"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="99"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="140"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="172"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="213"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="240"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="266"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="306"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN08268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="345" mass="35301" checksum="29AA790A352F7365" modified="2018-04-25" version="1">MHRHRELCERAVDPLEIAAGLEAHGVTDRTAARFRHRDVFALAEEMYARMPRDSDIEPETQHAASDTPRGRRPVWAALALLPGALSALTLVGLDFTDGRMRLAVGAGGVLAVSAALRAALSRGPLRATAHTVPATRAWTCWLLAYALLGDGLLTAAVAGGPDEAWAPATAPLLALAFAVAPGAWCAQLFGAVARRRLASSRGLDEFAASVRPLLLAVFALFLCALCALIGVTAAVLGQDAAYAGAGTLGALLLLARLLTAHGRTHAPAVVLGTAAAAEALAVSTVFAGRLPGCGFLAVPVETAVDAWGPATVPALACGAAALTLLVHAARTLTRASAHAPTDATP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JNE5</accession>
    <name>A0A2M9JNE5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ABC transporter substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_28795</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000014">
        <property type="protein sequence ID" value="PJN08384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08384">
        <property type="protein sequence ID" value="PJN08384"/>
        <property type="gene ID" value="CG723_28795"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025997">
        <property type="entry name" value="SBP_2_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13407">
        <property type="entry name" value="Peripla_BP_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014929074" evidence="1">
        <location>
            <begin position="30"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="domain" description="Peripla_BP_4" evidence="2">
        <location>
            <begin position="49"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN08384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="375" mass="39942" checksum="BBD6010FDA789EF2" modified="2018-04-25" version="1">MNPRTKRAAVVGVASAMAVALTGCGSSWLEPESDSAGKASARQNQDLKIGVLMPEKETARYEKFDYPHIKKEVEGLTSGKGRVLYANAEQNAKRQERQVDQMIADRVDVLILDAVDSKSIAGSVKKAKDAGIPVIAYDRLAEGPVDGYVSFDSDQVGHVQGMALLKALGSKASKNSRIVMMNGSVTDPNAALYKDGALAELKDQVTISKSYDTKDWKPENARANMAGAIQAIGARNIAGVYSANDGMAGGIITALKAAGVTDLPPVTGQDAELAAVQRIVAGDQYMTVYKPYPEEASTAAQMAVLIAQQRNIEFDALTKDRVDSPTTPDVPSLLVQVVPMTQSNIKSTVVRDGIYKVGDICTTKYATDCARIGLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JNG2</accession>
    <name>A0A2M9JNG2_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">dCTP deaminase, dUMP-forming</fullName>
            <ecNumber evidence="3">3.5.4.30</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Bifunctional dCTP deaminase:dUTPase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="3">DCD-DUT</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">dcd</name>
        <name evidence="5" type="ORF">CG723_28895</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CB01635</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Bifunctional enzyme that catalyzes both the deamination of dCTP to dUTP and the hydrolysis of dUTP to dUMP without releasing the toxic dUTP intermediate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>dCTP + 2 H2O = diphosphate + dUMP + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:19205"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61481"/>
            <dbReference type="ChEBI" id="CHEBI:246422"/>
            <dbReference type="EC" id="3.5.4.30"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Pyrimidine metabolism; dUMP biosynthesis; dUMP from dCTP: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homotrimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the dCTP deaminase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.30" evidence="3"/>
    <dbReference type="EMBL" id="NNBL01000014">
        <property type="protein sequence ID" value="PJN08400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08400">
        <property type="protein sequence ID" value="PJN08400"/>
        <property type="gene ID" value="CG723_28895"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00610">
        <property type="reaction ID" value="UER00667"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033973">
        <property type="term" value="F:dCTP deaminase (dUMP-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008829">
        <property type="term" value="F:dCTP deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006226">
        <property type="term" value="P:dUMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006229">
        <property type="term" value="P:dUTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07557">
        <property type="entry name" value="trimeric_dUTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00146">
        <property type="entry name" value="dCTP_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011962">
        <property type="entry name" value="dCTP_deaminase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029054">
        <property type="entry name" value="dUTPase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036157">
        <property type="entry name" value="dUTPase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033704">
        <property type="entry name" value="dUTPase_trimeric"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00692">
        <property type="entry name" value="dUTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51283">
        <property type="entry name" value="SSF51283"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02274">
        <property type="entry name" value="dCTP_deam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 3" id="KW-0546">Nucleotide metabolism</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="dUTPase" evidence="4">
        <location>
            <begin position="70"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="3">
        <location>
            <position position="129"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="101"/>
            <end position="106"/>
        </location>
        <ligand>
            <name>dCTP</name>
            <dbReference type="ChEBI" id="CHEBI:61481"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="119"/>
        </location>
        <ligand>
            <name>dCTP</name>
            <dbReference type="ChEBI" id="CHEBI:61481"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="127"/>
            <end position="129"/>
        </location>
        <ligand>
            <name>dCTP</name>
            <dbReference type="ChEBI" id="CHEBI:61481"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="148"/>
        </location>
        <ligand>
            <name>dCTP</name>
            <dbReference type="ChEBI" id="CHEBI:61481"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="162"/>
        </location>
        <ligand>
            <name>dCTP</name>
            <dbReference type="ChEBI" id="CHEBI:61481"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="174"/>
        </location>
        <ligand>
            <name>dCTP</name>
            <dbReference type="ChEBI" id="CHEBI:61481"/>
        </ligand>
    </feature>
    <feature type="site" description="Important for bifunctional activity" evidence="3">
        <location>
            <begin position="116"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PJN08400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="191" mass="21494" checksum="5463FE3597D8788F" modified="2018-04-25" version="1">MLLSDKDIRAEIDAGRVRIDPYDESMVQPSSIDVRLDRYFRVFENHRYPHIDPAVEQADLTRLVEPEGDEPFILHPGEFVLASTYEVISLPDDLASRLEGKSSLGRLGLVTHSTAGFIDPGFSGHVTLELSNLATLPIKLWPGMKIGQLCMFRLSSPAEFPYGNERYGSRYQGQRGPTASRSFLNFHRTQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JPC5</accession>
    <name>A0A2M9JPC5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CG723_26945</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000012">
        <property type="protein sequence ID" value="PJN08724.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08724">
        <property type="protein sequence ID" value="PJN08724"/>
        <property type="gene ID" value="CG723_26945"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001034">
        <property type="entry name" value="DeoR_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013196">
        <property type="entry name" value="HTH_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028349">
        <property type="entry name" value="PafC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018356">
        <property type="entry name" value="Tscrpt_reg_HTH_DeoR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026881">
        <property type="entry name" value="WYL_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08279">
        <property type="entry name" value="HTH_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13280">
        <property type="entry name" value="WYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016838">
        <property type="entry name" value="PafC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00894">
        <property type="entry name" value="HTH_DEOR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51000">
        <property type="entry name" value="HTH_DEOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH deoR-type" evidence="4">
        <location>
            <begin position="5"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PJN08724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="331" mass="36032" checksum="F883D2B2B2D6AEE0" modified="2018-04-25" version="1">MTTDTPARLLQLLSLLQTPREWPGGELAARLSVSRRTVRRDVDRLRDLGYPVQASMGAEGGYRLVAGKALPPLVLDDEEAVAIAVGLRAGAGHAVEGVEEASVRALAKLEQVLPSRLRHRVSTLQAATMPLTGGDGASIATETLTVLASATAGQERLRFRYRSGDGTESRRLTEPYRMVSTGRRWYLVAYDIDRDDWRTFRVDRVAEPFATGARFAPRELPTGDAAEYLRRSMSGRGRPSYDIDVTFEAPADFVVARLPSALGAPEAQPDGTCRLRATATDSVEWLALRLALVDCEFTVHGPDQLADYLRELSSRLARATDGPVRSSPSGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JPC8</accession>
    <name>A0A2M9JPC8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">3-alpha-hydroxysteroid dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CG723_26965</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000012">
        <property type="protein sequence ID" value="PJN08728.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08728">
        <property type="protein sequence ID" value="PJN08728"/>
        <property type="gene ID" value="CG723_26965"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PJN08728.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="254" mass="26164" checksum="5C7AAF1CA5A22625" modified="2018-04-25" version="1">MNNLTGKTVLVTGGARGIGAEIARRAVEAGANVVVTDVLEAEGKALAAELGDRARFMRHDVTSEEDWTAAAAFATAEFGGIDGLVNNAGISTGQPLETETVEHFRKVLDINLTGVFIGMKTAINAMKDNGGGSIVNISSAAGLMGLALTGSYGASKWGVRGLTKLAAVEQGTAKIRVNSVHPGMIYTPMTAQLGIQQGDGGYPNTPMGRVGEADEIAKATVFLLSDDSSYVTGAELAVDGGWTTGPTVKYVMGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JPI1</accession>
    <name>A0A2M9JPI1_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 12">Dolichyl-phosphate-mannose--protein mannosyltransferase</fullName>
            <ecNumber evidence="6 12">2.4.1.109</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">CG723_27180</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">CB01635</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Transfers mannose from Dol-P-mannose to Ser or Thr residues on proteins.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 12">
            <text>a dolichyl beta-D-mannosyl phosphate + L-seryl-[protein] = 3-O-(alpha-D-mannosyl)-L-seryl-[protein] + a dolichyl phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17377"/>
            <dbReference type="Rhea" id="RHEA-COMP:9517"/>
            <dbReference type="Rhea" id="RHEA-COMP:9527"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:13546"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:57683"/>
            <dbReference type="ChEBI" id="CHEBI:58211"/>
            <dbReference type="ChEBI" id="CHEBI:137321"/>
            <dbReference type="EC" id="2.4.1.109"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 12">
            <text>a dolichyl beta-D-mannosyl phosphate + L-threonyl-[protein] = 3-O-(alpha-D-mannosyl)-L-threonyl-[protein] + a dolichyl phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:53396"/>
            <dbReference type="Rhea" id="RHEA-COMP:9517"/>
            <dbReference type="Rhea" id="RHEA-COMP:9527"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:13547"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:57683"/>
            <dbReference type="ChEBI" id="CHEBI:58211"/>
            <dbReference type="ChEBI" id="CHEBI:137323"/>
            <dbReference type="EC" id="2.4.1.109"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4 12">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="12">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 12">Belongs to the glycosyltransferase 39 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.109" evidence="6 12"/>
    <dbReference type="EMBL" id="NNBL01000012">
        <property type="protein sequence ID" value="PJN08766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08766">
        <property type="protein sequence ID" value="PJN08766"/>
        <property type="gene ID" value="CG723_27180"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004169">
        <property type="term" value="F:dolichyl-phosphate-mannose-protein mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027005">
        <property type="entry name" value="GlyclTrfase_39-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003342">
        <property type="entry name" value="Glyco_trans_39/83"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032421">
        <property type="entry name" value="PMT_4TMC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10050">
        <property type="entry name" value="PTHR10050"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02366">
        <property type="entry name" value="PMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16192">
        <property type="entry name" value="PMT_4TMC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 12" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="11 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 12 16" id="KW-0808">Transferase</keyword>
    <keyword evidence="9 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="110"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="206"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="234"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="258"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="332"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="370"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="493"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="517"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="540"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="575"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="domain" description="PMT" evidence="14">
        <location>
            <begin position="118"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="domain" description="PMT_4TMC" evidence="15">
        <location>
            <begin position="424"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="28"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00007222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU367007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF02366"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF16192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="PJN08766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="618" mass="68507" checksum="DCB09AFB27BDC2D3" modified="2018-04-25" version="1">MSRIHPRRGGDRPTRSGRTRDSHSDVPYDGAVTSTASSPHSPSTSAPPGRSPGEGRQPSTWERRLRRFGHVARPRGDVGTRLVPPYAPPSSRLWATLGLSDGVARGMTRWSGWLGPLLVTLVAGLMRFWHLGSPKAVIFDETYYAKDAWALIHRGFEVNWDKNANDLILKTDGHVPIPHDAAYVVHPPVGKYVIGIGEWLFGFNPFGWRFMTAVLGTLCVLLVCRIGRRLFRSTFLGCLAGLLLAVDGLAFVMSRTALLDSILVFFVVAAFGCLVVDRDKARGKLAAALPRGEDGVPRPDAHIAETLRLGLRPWRLLAGLCLGLAAGTKWNGFIYVAAFGILTVLWDVGARRVAGAGRPYVTVLKRDLGWAFLSTVPVAVGTYVLSWLGWILSPADGTGGYFRNWAATDGRGGSWTWLFPDWVRSLWHYEHEVYKFNVGLSSPHIYQSNPWSWLVDGRPVSYFYESPLPGKDGCPAGAGDKCAREVLALGTPLLWWAAAFAVLYLLWRWFFRRDWRAGAIACAIAAGYLPWFNYQERTIFFFYAVVFVPFLCLAVAMLVGAILGPPGSGERRRVVGAAGAGVLVLLIVWNFVYFWPIYTGQAIPFHSWQSRMWLDSWV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JPI3</accession>
    <name>A0A2M9JPI3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">TetR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CG723_27295</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000012">
        <property type="protein sequence ID" value="PJN08784.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08784">
        <property type="protein sequence ID" value="PJN08784"/>
        <property type="gene ID" value="CG723_27295"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023772">
        <property type="entry name" value="DNA-bd_HTH_TetR-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045823">
        <property type="entry name" value="TetR_C_32"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19344">
        <property type="entry name" value="TetR_C_32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01081">
        <property type="entry name" value="HTH_TETR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="3">
        <location>
            <begin position="31"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="54"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PJN08784.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="227" mass="24983" checksum="528F27A74702A8B5" modified="2018-04-25" version="1">MMEPVATDPNSASPAGNDKPRRARRTRMTGAERRQQLLEIGRTLFAAKGFEGTSVEEIAAKAGVSKPVVYEHFGGKEGLYAVVVDREMRQLLDMVTGSLTAGHPRELCEQAAFALLDYIEEYTDGFRILVRDSPIPQSTGSFASLISDIATQVEDILGREFKNRGFDPKLAPLYAQALVGMVALTGQWWLDARKPKKAEVAAHLVNLAWHGLDGLEPKPRLIGHRKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JPJ8</accession>
    <name>A0A2M9JPJ8_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ribose-phosphate pyrophosphokinase</fullName>
            <shortName evidence="6">RPPK</shortName>
            <ecNumber evidence="6">2.7.6.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">5-phospho-D-ribosyl alpha-1-diphosphate</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Phosphoribosyl diphosphate synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Phosphoribosyl pyrophosphate synthase</fullName>
            <shortName evidence="6">P-Rib-PP synthase</shortName>
            <shortName evidence="6">PRPP synthase</shortName>
            <shortName evidence="6">PRPPase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">prs</name>
        <name evidence="8" type="ORF">CG723_27325</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CB01635</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>ATP + D-ribose 5-phosphate = 5-phospho-alpha-D-ribose 1-diphosphate + AMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15609"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="ChEBI" id="CHEBI:78346"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.7.6.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="6">Binds 2 Mg(2+) ions per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="6">Metabolic intermediate biosynthesis; 5-phospho-alpha-D-ribose 1-diphosphate biosynthesis; 5-phospho-alpha-D-ribose 1-diphosphate from D-ribose 5-phosphate (route I): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homohexamer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.6.1" evidence="6"/>
    <dbReference type="EMBL" id="NNBL01000012">
        <property type="protein sequence ID" value="PJN08790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08790">
        <property type="protein sequence ID" value="PJN08790"/>
        <property type="gene ID" value="CG723_27325"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00087">
        <property type="reaction ID" value="UER00172"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004749">
        <property type="term" value="F:ribose phosphate diphosphokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006015">
        <property type="term" value="P:5-phosphoribose 1-diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009165">
        <property type="term" value="P:nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009156">
        <property type="term" value="P:ribonucleoside monophosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00583_B">
        <property type="entry name" value="RibP_PPkinase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000842">
        <property type="entry name" value="PRib_PP_synth_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029099">
        <property type="entry name" value="Pribosyltran_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRibTrfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005946">
        <property type="entry name" value="Rib-P_diPkinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037515">
        <property type="entry name" value="Rib-P_diPkinase_bac"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10210">
        <property type="entry name" value="PTHR10210"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14572">
        <property type="entry name" value="Pribosyl_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13793">
        <property type="entry name" value="Pribosyltran_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="SSF53271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01251">
        <property type="entry name" value="ribP_PPkin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00114">
        <property type="entry name" value="PRPP_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 6 8" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 6" id="KW-0545">Nucleotide biosynthesis</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 6 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pribosyltran_N" evidence="7">
        <location>
            <begin position="12"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Ribose-5-phosphate binding" evidence="6">
        <location>
            <begin position="233"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="201"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="45"/>
            <end position="47"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="104"/>
            <end position="105"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="138"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="178"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="203"/>
        </location>
        <ligand>
            <name>D-ribose 5-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:78346"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="229"/>
        </location>
        <ligand>
            <name>D-ribose 5-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:78346"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF13793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PJN08790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="325" mass="35267" checksum="9743022CC57CA749" modified="2018-04-25" version="1">MSGIKTTGEKKLMLFSGRAHPELAEEVAHALGVGIVPTKAFDFANGEIYVRYQESARGADCFLIQSHTAPINKWIMEQLIMIDALKRASARSITVIVPFYGYARQDKKHRGREPISARLVADLMKTAGADRILTVDLHTDQIQGFFDGPVDHLFALPILADYVGAKVDRAKLTVVSPDAGRVRVADRWCDRLGAPLAIVHKRRDKDVANQVTVHEVVGDVKGRVCVLVDDMIDTGGTICAAADALFAHGAEDVIVTATHGVLSGPAADRLKNSKVSEFVFTDTLPTPGELELDKITVLSIAPTIARAVREVFEDGSVTSLFEEQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-05-25" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JPK1</accession>
    <name>A0A2M9JPK1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Penicillin-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_27175</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000012">
        <property type="protein sequence ID" value="PJN08765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08765">
        <property type="protein sequence ID" value="PJN08765"/>
        <property type="gene ID" value="CG723_27175"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008658">
        <property type="term" value="F:penicillin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001460">
        <property type="entry name" value="PCN-bd_Tpept"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00905">
        <property type="entry name" value="Transpeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="domain" description="Transpeptidase" evidence="2">
        <location>
            <begin position="266"/>
            <end position="541"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN08765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="545" mass="56083" checksum="74EA695566316AC7" modified="2018-04-25" version="1">MRKGAKAAVIGGVFAIMVGGAGYGAYNVVTAVTGSGGSSTAGAPSPRRTGPPTADEIKDVSQKFLAAWAKSDPDSASTYTNNAESALSALTGWHDDAHITQTTLTAGAPSGAQVPFKVKATVSFEGKKKTLSYDSSLKIVRGLNTGRALVDWQASVVHPDMRRGDTLVTGEASAPPIEAVDRSGAVLTKEKYPSLGPILDQLREKYGDTAGGRAGVETYIQPENEDAGTKTLLTLVKGKAGELHTTLSATAQAAAEKAVKSFDESSVVAVQPSTGQVLAVANHRQDGFNAAFQGEQAPGSTMKIITTAMLIDNGVASVSSPAPCPDTATWQSQTFHNLPGMKANEGANLADSFARSCNTAFVKLIDEKPLTDESLTREAQDRFGLGQDNWKTGIASADGKIPPSGGPDRAANAIGQGQIQMNPLNMASVTATAKTGVFRQPVIVPRSLDDRQLAPARGLAPSTAAQLRQMMYRTATVGTAAQVMAGLGPEIGAKTGSAEVTGQTKSNSWFTAYRGDVAAAAVTEEGGHGGDAAGPIVAAVLRAGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JPY2</accession>
    <name>A0A2M9JPY2_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Histidine kinase</fullName>
            <ecNumber evidence="3">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CG723_25870</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CB01635</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="3"/>
    <dbReference type="EMBL" id="NNBL01000011">
        <property type="protein sequence ID" value="PJN08916.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08916">
        <property type="protein sequence ID" value="PJN08916"/>
        <property type="gene ID" value="CG723_25870"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00672">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00304">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="29"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="149"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="9">
        <location>
            <begin position="170"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="8">
        <location>
            <begin position="237"/>
            <end position="427"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PJN08916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="428" mass="45878" checksum="CD4E0B1B631A61BA" modified="2018-04-25" version="1">MTPAQQADPSRPGPRPRLPAWTATLTWKAAVFITVMCCALAAFLGALVHVSVSNQTVGQARDHALDRLDEATKAYEAGARLGPLAGVDPPDLPDSLRRLATDGERGTMVRSHAKQPTMWAAGPIDRNRVLAVEVDYSQGARTIDGLDRAIVGSSVLAIGATLLVGAFAVTRVTRRLHATARVARRISGGDLDARVGDPRTRNPARHQDEVAAVAGALDSMASSLQRKLLSEQRFTADVAHELRTPLTGLHAAAELLPPGRPTELVRDRVAALRTLTEDLLEISRLDARSERVDLDDNWLGPLAERVVRGSGTETEVVVVRDVCVLTDRRRLERVLGNLVANAHRHGRPPVVVTVDGPVITVRDHGEGYPDYLVEGGPQRFRTEGGAKGHGLGLTIALGQAEVLDASLRFTNAEDGGAMATLTLDDQQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JQ71</accession>
    <name>A0A2M9JQ71_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_25995</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000011">
        <property type="protein sequence ID" value="PJN08937.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08937">
        <property type="protein sequence ID" value="PJN08937"/>
        <property type="gene ID" value="CG723_25995"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="256"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN08937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="282" mass="29723" checksum="F9E071CCD3951929" modified="2018-04-25" version="1">MPSDATADSAGTPAPQARAAGALLLCRADPATAGPAAQLLRERMLLAQAGPEWSVLIPEGKPWLHGGEPVDSVLAGWAAALAVSAPWPVLALWWDAEHGGYTLASGFRRPVGYVWLANGTPVGEDEAMRTFAARLGLDPVLDMQSLEALTRPDSAADARARLLGLLSVLTRAGLTLPPGMIPGEPADRLRAVARVQPGAEYIVWSGWRDAVRAELDVVERSAMGPWLRGPKARTAAAGQLAVGIPLTVWGLRRRGIGWAVAGALLVVHGALGLAYDRLRAWD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JQA8</accession>
    <name>A0A2M9JQA8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">RNA polymerase subunit sigma-70</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CG723_26150</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000011">
        <property type="protein sequence ID" value="PJN08967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08967">
        <property type="protein sequence ID" value="PJN08967"/>
        <property type="gene ID" value="CG723_26150"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014322">
        <property type="entry name" value="RNA_pol_sigma-B/F/G"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000943">
        <property type="entry name" value="RNA_pol_sigma70"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007624">
        <property type="entry name" value="RNA_pol_sigma70_r3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007630">
        <property type="entry name" value="RNA_pol_sigma70_r4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04539">
        <property type="entry name" value="Sigma70_r3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04545">
        <property type="entry name" value="Sigma70_r4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00046">
        <property type="entry name" value="SIGMA70FCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02980">
        <property type="entry name" value="SigBFG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0731">Sigma factor</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="7">
        <location>
            <begin position="128"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r3" evidence="6">
        <location>
            <begin position="209"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4" evidence="8">
        <location>
            <begin position="293"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="80"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04539"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PJN08967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="348" mass="38814" checksum="A2EA112D56820594" modified="2018-04-25" version="1">MTNGDGPVRDEKHGTQDLPADGGEGMRRLADGIPEQQARPHPEDPADLERPGPPVVADASEQAEPAGGEKISAGPDARRAGWMSEHERHGDQQRTHDPRDRSGARLMFIELRTLKDGSPEYADLRNQLVRMHLPLVEHLARRFRNRGEPLDDLTQVATIGLIKSVDRFDPERGVEFSTYATPTVVGEIKRHFRDKGWAVRVPRRLQELRLALTTATAELSQLHGRSPTVHELAEKLAISEEEVLEGLESANAYSTLSLDVPDTDDESPAVADTLGSEDEALEGVEYRESLKPLLEDLPPREKRILLLRFFGNMTQSQIAQEVGISQMHVSRLLARTLAQLREKLLVEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-05-25" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JQD1</accession>
    <name>A0A2M9JQD1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">LacI family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CG723_24360</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000010">
        <property type="protein sequence ID" value="PJN09066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN09066">
        <property type="protein sequence ID" value="PJN09066"/>
        <property type="gene ID" value="CG723_24360"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01392">
        <property type="entry name" value="HTH_LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000843">
        <property type="entry name" value="HTH_LacI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046335">
        <property type="entry name" value="LacI/GalR-like_sensor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00356">
        <property type="entry name" value="LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13377">
        <property type="entry name" value="Peripla_BP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00354">
        <property type="entry name" value="HTH_LACI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50932">
        <property type="entry name" value="HTH_LACI_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH lacI-type" evidence="4">
        <location>
            <begin position="4"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PJN09066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="340" mass="36833" checksum="36474BC5397510E7" modified="2018-04-25" version="1">MAKVTRDDVARLAGTSTAVVSYVINNGPRPVAPATRERVLAAIKELGYRPDRVAQAMASRRTDLIGMIVPDARQPFFAEMAHAVEQAASERGKMVLVGNSDYVEEREVHYLRAFLGMRVSGLILVSHGLNDSAAAEIEAWDARVVLLHERPEAIDDVAVVIDDIGGAQLATRHLLEHGHPYVACLGGTAETPSVGDPVSDHVEGWRRAMHEAGLPTEGRLFEAPYNRYDAYKIGLELLAGPQRPPAIFCSTDDQAFGILRAARELRIDVPGELAVAGFDDVKEAGLTDPPLTTVASDRSAMARSAVDLVLDDSLRVAGSRRERLKVFPSRLVVRQSCGCP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JR32</accession>
    <name>A0A2M9JR32_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CG723_23420</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CB01635</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000009">
        <property type="protein sequence ID" value="PJN09302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN09302">
        <property type="protein sequence ID" value="PJN09302"/>
        <property type="gene ID" value="CG723_23420"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="42"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="70"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="103"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="133"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="160"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="201"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="241"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="266"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="291"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="334"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="359"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="7">
        <location>
            <begin position="2"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="383"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="384"/>
            <end position="398"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PJN09302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="405" mass="41025" checksum="160616EDC5B4B878" modified="2018-04-25" version="1">MPLALLALAVVAFGIGTTEFATMGLLPQIADGIDVSVPHAGNLVSAYALGVVVGAPVLTGIGARVTHKRLLLLLSGLFVVGNIASALAPSFGLLFAARFLAGLPHGALFGVGAVVASRLVAPERAARAVSKMFLGLTIANIVGVPASTALGQHLGWRSAYWAVAVIGIVALASLALFVPHQPRGRQSGIRHELRAMGNRQVAIGLATAVVGFGGFFAVYSYLVPMLTNVTGISDSSTTLVLALYGVGMTLGTVIAGPLTDRALRPTLYAGLALLAAALVTFYFTVNSTVPALVTIAFIGAMGSLITTPVQMLLMAKAQNAPTMAAASNHSAFNLANAGGAWLGGLAISAGWGWASPNLVGAALALAGLGLAFTGGLMDRGTRRSEVVTSSRAEHSAEADEVTAAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JR84</accession>
    <name>A0A2M9JR84_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Type IV secretion protein Rhs</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_24060</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000009">
        <property type="protein sequence ID" value="PJN09400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN09400">
        <property type="protein sequence ID" value="PJN09400"/>
        <property type="gene ID" value="CG723_24060"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045351">
        <property type="entry name" value="DUF6531"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001826">
        <property type="entry name" value="RHS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022385">
        <property type="entry name" value="Rhs_assc_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031325">
        <property type="entry name" value="RHS_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006530">
        <property type="entry name" value="YD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20148">
        <property type="entry name" value="DUF6531"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03527">
        <property type="entry name" value="RHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05593">
        <property type="entry name" value="RHS_repeat"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03696">
        <property type="entry name" value="Rhs_assc_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01643">
        <property type="entry name" value="YD_repeat_2x"/>
        <property type="match status" value="14"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6531" evidence="2">
        <location>
            <begin position="419"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="65"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="236"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="385"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1533"/>
            <end position="1577"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="385"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1557"/>
            <end position="1577"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN09400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="1577" mass="171679" checksum="963FADD9C7BA4B3D" modified="2018-04-25" version="1">MGLGDIVDGVKGGINKGLSVGEDLIDEGKKKVGEGVDYATNKVGDGLDHVGLHGAADAVEDWGDDVASDLGATPGEQQLGQTEEADELVHGNPDKIRESSKHLKDFHTAFDHVSQGMKKVDSSGWAGEGGDAFRKKFGVHPTKWAEASDACDKAAGALDAYADTVKWAQGKAKDAIDLYKKGTKASSDAVDAYNKKADAYNAKLKANEDPGPRPEPFQDPGKADIEKAHETLTEARKQRNTAASDAQGKVKAALAHAPAEPPPLDRLGNSIVDGYQAYNTELTHVVGGALKGTAGLLNFVRGLNPTDPYNLTHPAAYMQNVSMTLSGLVSTAAHPERIVTAAVDGFKKDPSEFFGRLIPELIGTKGAGLARSGLRLGLKTAAKEGLEEGAESAARRTVRDGPEGRGEKPRDKVEHDPTDPVDLTTGRMYLPQTDISLPGSLPLEFTRRVESGYTLGRWFGPSWSSTVDERLEIDAEGVVHVDADGRILAYPHPAPGIPTLPSHGTPLYLDRTDDGYTITEPDTGRVRHFADRGEQAAILEQIDDRNGNWVTFEHARDGTPLAIVSSSGHHLRITTRDGRITALHLGGGAPDGGDLELKRYGYDDGHLTEVVNSSGLPLRFTYDERGRVTSWTDSNDRSYTYEYDGQDRCVAEGGAEGHLVLRLAYDDTDPVTGHRVTTVTNGAGHTRRYLIDDTCHVTAEIDPLGAVTRFERDLRGRLLSRTDPLGHTSRYAYDEQGNLVLAKRADGREISAEYNALNLPVKVTGPDGSVHRYFYDERGNRTGFTNSAGKTTTFTYDKAGHLTSVVDPFGHSSAVECDRTGLPIRITDPRGAVTRYRRDPLGHPVEVTEPSGATTLLEWTVEGLLTRRTAADGAAESWTYDGEGNRTSHTDRLGGTTRYEYTHFDVLVGRTGPDGGRHEFTYDEELRLTEVTNPQGMSWSYSYDPAGRLVGERDFDGREISYTHDAGGQLTSRTNMLGQTIRYERDCLGRIVSKDAAGQVTSYAYDLTDQLAKAAGPDGSALTLLRDRHGNVRTETVDGRTLRFTHDDLGRRTSRTTPGGATTTWTYDPLGNVAQMIAAGRPITFTYDADAREVRRTIADAFTLAQAYDPVGRLTSQTAMSNDRTLQERAYAYRADGHLTAVEDLLSGARRFELDAVGRVTSVTAEGWTESYAYDAVGNQTQAAWPATHPGHEATGPRAYAGTRLIRAGQVRYEHDALGRIVLRQKKRLSGRPDTWRYEWDAEDRLTSVLTPDGIRWRYTYDPIGRRTAKLRLDADGDTVVERVTFTWDGTTVCEQTSVSRKLPHPVTLTWDHRDQRPVAQNERITAADAPQEEIDSRFFAIVTDLVGTPTELVDEQGTIAWRARSTLWGTTAWPADSPAYTPLRFPGQYYDPETGLHYNYFRHYDPETARYLTADPLGLAPSPNPGGYVHNPLTWSDPLGLAPKCPVEKANKATDKIIERAAEGKMRKDSGYHPHFGDERVLEILKKPDAVYLSEGGRGNLIFRQGEDIVVTKGPGAGAGDVITGYGPSGVKGESGAKALGGSADDPGSPVTHDDIVNGNVPSSRGGTMPPAQQIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JRK5</accession>
    <name>A0A2M9JRK5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">SAM-dependent methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_22500</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000008">
        <property type="protein sequence ID" value="PJN09520.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN09520">
        <property type="protein sequence ID" value="PJN09520"/>
        <property type="gene ID" value="CG723_22500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013217">
        <property type="entry name" value="Methyltransf_12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08242">
        <property type="entry name" value="Methyltransf_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransf_12" evidence="1">
        <location>
            <begin position="41"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN09520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="241" mass="25971" checksum="CCFEEC150286A0D1" modified="2018-04-25" version="1">MSGADYTVSVEFYDLLQAETDRRLAKRRFAEAARHARHGILDVGAGTGIVTETLLTASAAPIHAVEPAAPMRAALLSRLAGLGADQRARVTLHPEPIERAGLEEVADLAIASNIIACLDPATRRSTWEAVSRALLPGGLLLFDPPPTELPTGREKVGRLGPVRVGPDLYGADITRESEGGIVRMVFTYHVERDGRVLRQQRETFELWPASASQIGAELEAQGLQVVHAPSPDLLAARRPAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JRV4</accession>
    <name>A0A2M9JRV4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_22985</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000008">
        <property type="protein sequence ID" value="PJN09599.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN09599">
        <property type="protein sequence ID" value="PJN09599"/>
        <property type="gene ID" value="CG723_22985"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="34"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="58"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="89"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="132"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="163"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN09599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="198" mass="21820" checksum="BA969A7CB3E6B888" modified="2018-04-25" version="1">METANSGRRTGNLLFAFAPWIIFYVVASPSTWEYAALAALVAAVVLNLPDLRRGSFKALEVAGILFFGVIAVLALLLDRKDMLWLETYAQVLASSVIAVVALGSLAFVPFTEQYARESTPREVWGTPLFRHVNRVLTLVWGGVFVAMAVLGLVAVHTTSGADWFNWIIPVVLLILAVRFTERYPDQVRERAKAARTAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-09-29" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JRV9</accession>
    <name>A0A2M9JRV9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_22950</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000008">
        <property type="protein sequence ID" value="PJN09593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN09593">
        <property type="protein sequence ID" value="PJN09593"/>
        <property type="gene ID" value="CG723_22950"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002397">
        <property type="entry name" value="Cyt_P450_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00359">
        <property type="entry name" value="BP450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="SSF48264"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN09593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="86" mass="9788" checksum="091F9409B67BA70B" modified="2018-04-25" version="1">MRPFGPPHSPGRVAALRGEIVQLTKDLAEGFQEGRQIDVVDDFAYPLPITVICRLLGVPPEDEHLFHAWPDVCARDHRGRRHRARK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JRX4</accession>
    <name>A0A2M9JRX4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_23020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000008">
        <property type="protein sequence ID" value="PJN09603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN09603">
        <property type="protein sequence ID" value="PJN09603"/>
        <property type="gene ID" value="CG723_23020"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.150.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007361">
        <property type="entry name" value="DUF427"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038694">
        <property type="entry name" value="DUF427_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04248">
        <property type="entry name" value="NTP_transf_9"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NTP_transf_9" evidence="1">
        <location>
            <begin position="38"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="domain" description="NTP_transf_9" evidence="1">
        <location>
            <begin position="163"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN09603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="286" mass="32567" checksum="7D6BEB483E2E93CC" modified="2018-04-25" version="1">MGLSWQQGPLSAGAIGHFLTPEPLPERLLFAERLRRRMRVKFNGSWIADSENVILLHEPGRYPVAYFPREDVDEQSLIPSSKVTHHRDLGDTAWYAVHAGERTTERAAWEFTALPGYAADLQGRIAFAWRAMDAFYEEDERILGHAADPYHRIDIRNTSRTLEVRLGDTLIARSEHPLVLFESGFAPRWYVPRADIDQTQLHPVDDQTFCPYKGLCNYYDIGDARHAAWSYTNAYQEVDRISDLVSFEADKVEVSLDGTRLHLEPGQSVIPHGVDRGLDVDEVKAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JS09</accession>
    <name>A0A2M9JS09_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_20730</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000007">
        <property type="protein sequence ID" value="PJN09644.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN09644">
        <property type="protein sequence ID" value="PJN09644"/>
        <property type="gene ID" value="CG723_20730"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="28"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN09644.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="65" mass="7691" checksum="FE06896DE2C2D656" modified="2018-04-25" version="1">MYEYEIHQIRAAELVRQAEHNRLVREAREARRNRRAERRAASAGQDTEGRVNSPRSRRSRFARAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-05-25" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JS70</accession>
    <name>A0A2M9JS70_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 6 7">50S ribosomal protein L19</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">rplS</name>
        <name evidence="8" type="ORF">CG723_21300</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CB01635</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 6 7">This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 6 7">Belongs to the bacterial ribosomal protein bL19 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000007">
        <property type="protein sequence ID" value="PJN09741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_054235359.1">
        <property type="nucleotide sequence ID" value="NZ_NNBL01000007.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN09741">
        <property type="protein sequence ID" value="PJN09741"/>
        <property type="gene ID" value="CG723_21300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00402">
        <property type="entry name" value="Ribosomal_L19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038657">
        <property type="entry name" value="L19_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001857">
        <property type="entry name" value="Ribosomal_L19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018257">
        <property type="entry name" value="Ribosomal_L19_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15680">
        <property type="entry name" value="PTHR15680"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01245">
        <property type="entry name" value="Ribosomal_L19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002191">
        <property type="entry name" value="Ribosomal_L19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00061">
        <property type="entry name" value="RIBOSOMALL19"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="SSF50104"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01024">
        <property type="entry name" value="rplS_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01015">
        <property type="entry name" value="RIBOSOMAL_L19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6 7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 6 8" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00402"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PJN09741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="116" mass="13185" checksum="13E9E674B0086883" modified="2018-04-25" version="1">MSHLLDSVDSASLRSDIPAFRPGDTVNVHVRVIEGNRSRVQQFKGVVIRRQGAGVRETFTVRKVSFSVGVERTFPVHTPIVEKIELVTRGDVRRAKLYYLRDLRGKAAKIKEKRDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JSC3</accession>
    <name>A0A2M9JSC3_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Glutamate--tRNA ligase</fullName>
            <ecNumber evidence="8">6.1.1.17</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Glutamyl-tRNA synthetase</fullName>
            <shortName evidence="8">GluRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">gltX</name>
        <name evidence="12" type="ORF">CG723_20990</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">CB01635</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>ATP + L-glutamate + tRNA(Glu) = AMP + diphosphate + L-glutamyl-tRNA(Glu)</text>
            <dbReference type="Rhea" id="RHEA:23540"/>
            <dbReference type="Rhea" id="RHEA-COMP:9663"/>
            <dbReference type="Rhea" id="RHEA-COMP:9680"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78520"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.17"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="8">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.17" evidence="8"/>
    <dbReference type="EMBL" id="NNBL01000007">
        <property type="protein sequence ID" value="PJN09687.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN09687">
        <property type="protein sequence ID" value="PJN09687"/>
        <property type="gene ID" value="CG723_20990"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004818">
        <property type="term" value="F:glutamate-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006424">
        <property type="term" value="P:glutamyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00808">
        <property type="entry name" value="GluRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.350">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00022">
        <property type="entry name" value="Glu_tRNA_synth_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045462">
        <property type="entry name" value="aa-tRNA-synth_I_cd-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020751">
        <property type="entry name" value="aa-tRNA-synth_I_codon-bd_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008925">
        <property type="entry name" value="aa_tRNA-synth_I_cd-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004527">
        <property type="entry name" value="Glu-tRNA-ligase_bac/mito"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000924">
        <property type="entry name" value="Glu/Gln-tRNA-synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020058">
        <property type="entry name" value="Glu/Gln-tRNA-synth_Ib_cat-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033910">
        <property type="entry name" value="GluRS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19269">
        <property type="entry name" value="Anticodon_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00749">
        <property type="entry name" value="tRNA-synt_1c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00987">
        <property type="entry name" value="TRNASYNTHGLU"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48163">
        <property type="entry name" value="SSF48163"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00464">
        <property type="entry name" value="gltX_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8 9" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5 8 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 8 9" id="KW-0436">Ligase</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 8 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 8 9" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="tRNA-synt_1c" evidence="10">
        <location>
            <begin position="5"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="domain" description="Anticodon_2" evidence="11">
        <location>
            <begin position="340"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'HIGH' region" evidence="8">
        <location>
            <begin position="12"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'KMSKS' region" evidence="8">
        <location>
            <begin position="257"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="109"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="111"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="136"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="138"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="260"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001818"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU363037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF19269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PJN09687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="491" mass="54218" checksum="0125AFE46C267C00" modified="2018-04-25" version="1">MANANVRVRFCPSPTGNPHVGLVRTALFNWAYARHNQGVLVFRIEDTDAARDSEESYEQLLDAMRWLGFDWDEGPEIGGPHAPYRQSQRMDIYQDVAEKLLAAGHAYRCYCSTEELDARRDAARAAGKPSGYDGHCRDLSAEQIAAYEAEGRRPIVRFRMPDEAITFEDLVRGEITYQPENVPDFGIVRANGAPLYTLVNPVDDALMEITHVLRGEDLLSSTPRQIALYKALTELGIAKLTPAFGHLPYVMGEGNKKLSKRDPQASLNLYRERGFLPEGLLNYLSLLGWSFSADQDVFSIEDMVAKFDLADVNSNPARFDLKKAESINGDHIRMLDVKAFAAACEPWLRAPFANWAPEDFDQAAWEAIAPHAQTRVTVLSDITANVDFLFLKEPVEDEASWTKAMKGDPAGLLTTARAKLEAADWTSADALKEAVLAAGEEHGLKLGKAQAPVRVAVTGRTVGLPLFESLEILGKDKTLTRIDAALAKLTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JSF3</accession>
    <name>A0A2M9JSF3_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">tRNA pseudouridine synthase B</fullName>
            <ecNumber evidence="5">5.4.99.25</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">tRNA pseudouridine(55) synthase</fullName>
            <shortName evidence="5">Psi55 synthase</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">tRNA pseudouridylate synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">tRNA-uridine isomerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">truB</name>
        <name evidence="9" type="ORF">CG723_21665</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CB01635</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 5">
            <text>uridine(55) in tRNA = pseudouridine(55) in tRNA</text>
            <dbReference type="Rhea" id="RHEA:42532"/>
            <dbReference type="Rhea" id="RHEA-COMP:10101"/>
            <dbReference type="Rhea" id="RHEA-COMP:10102"/>
            <dbReference type="ChEBI" id="CHEBI:65314"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="EC" id="5.4.99.25"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the pseudouridine synthase TruB family. Type 1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.4.99.25" evidence="5"/>
    <dbReference type="EMBL" id="NNBL01000007">
        <property type="protein sequence ID" value="PJN09805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN09805">
        <property type="protein sequence ID" value="PJN09805"/>
        <property type="gene ID" value="CG723_21665"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106029">
        <property type="term" value="F:tRNA pseudouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031119">
        <property type="term" value="P:tRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02573">
        <property type="entry name" value="PseudoU_synth_EcTruB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01080">
        <property type="entry name" value="TruB_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002501">
        <property type="entry name" value="PsdUridine_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036974">
        <property type="entry name" value="PUA_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015225">
        <property type="entry name" value="tRNA_psdUridine_synth_fam2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014780">
        <property type="entry name" value="tRNA_psdUridine_synth_TruB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032819">
        <property type="entry name" value="TruB_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13767">
        <property type="entry name" value="PTHR13767"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09142">
        <property type="entry name" value="TruB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16198">
        <property type="entry name" value="TruB_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01509">
        <property type="entry name" value="TruB_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="SSF55120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="SSF88697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00431">
        <property type="entry name" value="TruB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0413">Isomerase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="TruB_N" evidence="6">
        <location>
            <begin position="32"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="domain" description="TruB_C_2" evidence="8">
        <location>
            <begin position="189"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="domain" description="TruB_C" evidence="7">
        <location>
            <begin position="244"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="5">
        <location>
            <position position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01509"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF09142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF16198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PJN09805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="302" mass="31849" checksum="D889319D4ADD6595" modified="2018-04-25" version="1">MTQKNTPTPDGLVIVDKPSGFTSHDVVAKMRGIAKTRRVGHAGTLDPMATGVLVLGVERATKLLGHLALTEKEYLGTIRLGQNTLTDDAEGDLTSSTDASGVARDAIDAGVAKLTGAIMQVPSKVSAIKINGVRSYKRAREGEEFEIPARPVTVSSFTVYDIRDAVAEDGTPVLDLVVSVVCSSGTYIRALARDLGADLGVGGHLTALRRTRVGPYKLDSARTLDQLQQELTVMPVADAATAAFPRWDVDAKRAKLLLNGVRLEVPGEYAGAGPVAVFDPEGVFLALVEESKGKAKSLAVFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JSL4</accession>
    <name>A0A2M9JSL4_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="11 12">Protein translocase subunit SecA</fullName>
            <ecNumber evidence="11">7.4.2.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">secA</name>
        <name evidence="17" type="ORF">CG723_21555</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">CB01635</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Monomer and homodimer. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF. Other proteins may also be involved.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Cell membrane</location>
            <topology evidence="11">Peripheral membrane protein</topology>
            <orientation evidence="11">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="11">Cytoplasm</location>
        </subcellularLocation>
        <text evidence="11">Distribution is 50-50.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 11 12">Belongs to the SecA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.4.2.8" evidence="11"/>
    <dbReference type="EMBL" id="NNBL01000007">
        <property type="protein sequence ID" value="PJN09860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN09860">
        <property type="protein sequence ID" value="PJN09860"/>
        <property type="gene ID" value="CG723_21555"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0065002">
        <property type="term" value="P:intracellular protein transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017038">
        <property type="term" value="P:protein import"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006605">
        <property type="term" value="P:protein targeting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd18803">
        <property type="entry name" value="SF2_C_secA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01382">
        <property type="entry name" value="SecA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000185">
        <property type="entry name" value="SecA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020937">
        <property type="entry name" value="SecA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011115">
        <property type="entry name" value="SecA_DEAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014018">
        <property type="entry name" value="SecA_motor_DEAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011130">
        <property type="entry name" value="SecA_preprotein_X-link_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044722">
        <property type="entry name" value="SecA_SF2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011116">
        <property type="entry name" value="SecA_Wing/Scaffold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036266">
        <property type="entry name" value="SecA_Wing/Scaffold_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036670">
        <property type="entry name" value="SecA_X-link_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30612">
        <property type="entry name" value="PTHR30612"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07517">
        <property type="entry name" value="SecA_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01043">
        <property type="entry name" value="SecA_PP_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07516">
        <property type="entry name" value="SecA_SW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00906">
        <property type="entry name" value="SECA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00957">
        <property type="entry name" value="SecA_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00958">
        <property type="entry name" value="SecA_PP_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81767">
        <property type="entry name" value="SSF81767"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81886">
        <property type="entry name" value="SSF81886"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00963">
        <property type="entry name" value="secA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01312">
        <property type="entry name" value="SECA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51196">
        <property type="entry name" value="SECA_MOTOR_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 11" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 11 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 11 12" id="KW-0653">Protein transport</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 11" id="KW-1278">Translocase</keyword>
    <keyword evidence="9 11 12" id="KW-0811">Translocation</keyword>
    <keyword evidence="2 11 12" id="KW-0813">Transport</keyword>
    <feature type="domain" description="SECA_MOTOR_DEAD" evidence="16">
        <location>
            <begin position="1"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="14">
        <location>
            <begin position="80"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="15">
        <location>
            <begin position="429"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="853"/>
            <end position="899"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="875"/>
            <end position="889"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="78"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="96"/>
            <end position="100"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="507"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007650"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="PJN09860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="899" mass="100671" checksum="D652F3EF62F41612" modified="2018-04-25" version="1">MRAGEGRILHKLQRIADQVNSVEEDFLALTDAELQALTAEFRQRLTEGESLDDLMPEAFAAIREAARRTLGMRHFDVQLMGGAALHLGNIAEMQTGEGKTLAATLPVYLNALAGKGVHLVTVNDYLAERDAAWMGRAYRFMGLTVGVVRTDMDPADRRIAYACDITYGTNTEFGFDYLRDNMAWSKDELVQRGHHFAIVDEADSILIDEARTPLIISGPADQPTHWYGVFAGLVRNMKGVPVQDEHFTTQADKDRLAELRATYDYEYDLKKQTVAILDRGVSYLEDQLGIENFYEAAHTPLIGHLNNALKAKEHFRNDKDYVVIDGEVLIVDEHTGRILAGRRYNEGLHQAIEAKEGVDIKDENQTLATITLQNFFRLYAKLGGMTGTAMTEAAEFHQIYKLHVVPIPTNRPMIRRDDPDLIYRTASAKFDAIVEDIAEKHAAGQPVLVGTTSVEKSELLSEQLRRRGIRHEVLNAKNHRREAQIVAQAGRKGAVTVATNMAGRGTDIMLGGNPEAMTAAALEERGPAEDDDSDRRHAVEERVTASAAAEHDEVKELGGLYVLGTERHESRRIDNQLRGRSGRQGDPGASRFYLSLEDDLMRLFRAQAVDRVMAMANLPESVPIENKMVTRAIASAQSQVEQQHFETRKEVLKFDEVLNRQRTLIYRERRRVLEGEDMRAQVLRFMDDTVGAYIANETAEGYPEEWDLDVLWAAFHELYPCGITADELDEAAGGRAELTAGLLVDAVTEDIHARYEERESELGAEALRDLERLVVLAVLDRKWREHLYEMDYLRDGIGLRYTLGREPIFEYEREGFDLFTAMMDAIKEESVGYVFNLDTTTDAPPSDALDAARRPDRLHFSAPTLDTAGGRQEGDFDAAPDEDAPRDAEPPGSSPRPSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-09-29" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JSQ9</accession>
    <name>A0A2M9JSQ9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">LysR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_19285</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LysR transcriptional regulatory family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000006">
        <property type="protein sequence ID" value="PJN09888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN09888">
        <property type="protein sequence ID" value="PJN09888"/>
        <property type="gene ID" value="CG723_19285"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005119">
        <property type="entry name" value="LysR_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000847">
        <property type="entry name" value="Tscrpt_reg_HTH_LysR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00126">
        <property type="entry name" value="HTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03466">
        <property type="entry name" value="LysR_substrate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00039">
        <property type="entry name" value="HTHLYSR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50931">
        <property type="entry name" value="HTH_LYSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH lysR-type" evidence="2">
        <location>
            <begin position="28"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN09888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="323" mass="35192" checksum="0C798E08C5D77134" modified="2018-04-25" version="1">MAHKQSSETRLSPSSDTEDIVTTLAPRLSYFAAVARTEHVTRAAHELEIPQSTLSRALVRLEQDLGVELFARHGRTVSLTPAGRTFLTSVDRALAEVGRAAESVRADADPASGKVAFGFLHTMGSETVPGLIRAFRADHPRIRFSLVQNYGEAMLERLRAGELDLCLTSPVPDEPGLVARRLDEQRLRLVVPDDHRLAGRKRVRLAEAADEPFVTLEPGYGLRRIADGLCAEAGFKPRVAFEGEETETLRGLVAAGLGVALLPPPAVPRPGVVELTVTGQRAVREIGVAWLDGHPDTPPVAAFKKFLLSRRGKLLSEWTRAQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JT58</accession>
    <name>A0A2M9JT58_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Elongation factor G</fullName>
            <shortName evidence="6">EF-G</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6 8" type="primary">fusA</name>
        <name evidence="8" type="ORF">CG723_20405</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CB01635</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000006">
        <property type="protein sequence ID" value="PJN10076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN10076">
        <property type="protein sequence ID" value="PJN10076"/>
        <property type="gene ID" value="CG723_20405"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd16262">
        <property type="entry name" value="EFG_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01434">
        <property type="entry name" value="EFG_mtEFG1_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03713">
        <property type="entry name" value="EFG_mtEFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00054_B">
        <property type="entry name" value="EF_G_EF_2_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041095">
        <property type="entry name" value="EFG_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009022">
        <property type="entry name" value="EFG_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035647">
        <property type="entry name" value="EFG_III/V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035649">
        <property type="entry name" value="EFG_V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000640">
        <property type="entry name" value="EFG_V-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004161">
        <property type="entry name" value="EFTu-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031157">
        <property type="entry name" value="G_TR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004540">
        <property type="entry name" value="Transl_elong_EFG/EF2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005517">
        <property type="entry name" value="Transl_elong_EFG/EF2_IV"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00679">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14492">
        <property type="entry name" value="EFG_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03764">
        <property type="entry name" value="EFG_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03144">
        <property type="entry name" value="GTP_EFTU_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00838">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00889">
        <property type="entry name" value="EFG_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="SSF50447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54980">
        <property type="entry name" value="SSF54980"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00484">
        <property type="entry name" value="EF-G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00301">
        <property type="entry name" value="G_TR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 6 8" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="5 6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4 6" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="7">
        <location>
            <begin position="9"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="18"/>
            <end position="25"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="86"/>
            <end position="90"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="140"/>
            <end position="143"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PJN10076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="708" mass="77597" checksum="216C83669E2A35E6" modified="2018-04-25" version="1">MATTSLDLAKVRNIGIMAHIDAGKTTTTERILFYTGVSYKIGEVHDGAATMDWMEQEQERGITITSAATTCHWPLNDVDHTINIIDTPGHVDFTVEVERSLRVLDGAVTVFDGVAGVEPQSETVWRQADRYGVPRICFVNKLDRTGAEFHRCVDMIVNRLGATPLVMQLPIGAEMDFQGVVDLVTMKAFVWSAEAAKGEAYDIVDIPATHTEAAEEWRGKLLEAVAENDEEMMELYLEGTEPSVDQLYAAIRRITIASGKGGDTTVTPVFCGTAFKNKGVQPLLDAVVRYLPSPLDVEAIEGHDVKDAETVVKRKPSDEEPLSALAFKIMSDPHLGKLTFVRVYSGRLESGTAVLNSVKGKKERIGKIYRMHANKREEIESVGAGDIVAVMGLKQTTTGETLCDDKQPVILESMDFPAPVIQVAIEPKSKGDQEKLGVAIQRLSEEDPSFQVHSDEETGQTIIGGMGELHLEVLVDRMKREFRVEANVGKPQVAYRETIRKAVERHDYTHKKQTGGTGQFAKVQIAIEPIDSGDATYEFVNKVTGGRIPREYIPSVDAGAQEAMQFGILAGYEMTGVRVILLDGGYHEVDSSELAFKIAGSQAFKEAARKASPVLLEPMMAVEVTTPEDYMGDVIGDINSRRGQIQAMEERSGARVVKGLVPLSEMFGYVGDLRSKTSGRASYSMQFDSYAEVPRNVAEEIIAKAKGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JT73</accession>
    <name>A0A2M9JT73_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CG723_20345</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000006">
        <property type="protein sequence ID" value="PJN10069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN10069">
        <property type="protein sequence ID" value="PJN10069"/>
        <property type="gene ID" value="CG723_20345"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PJN10069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="144" mass="14809" checksum="13057E0141FFC333" modified="2018-04-25" version="1">MMLTMQFTVRPDQGDPGGFDLGDMSVTGDLGTADSAGHTPDQGMVIHLSVTQLLDSLGDFLRGDAGTLAFTGVDTSFGLIFRRTTKGLSVASKGGVIARTSAPELGEAVLRAADRLALTLPAEDSAAADLSAALASFPRPVEDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JTC3</accession>
    <name>A0A2M9JTC3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">RNA polymerase subunit sigma-70</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CG723_19295</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CB01635</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2">Interacts transiently with the RNA polymerase catalytic core formed by RpoA, RpoB, RpoC and RpoZ (2 alpha, 1 beta, 1 beta' and 1 omega subunit) to form the RNA polymerase holoenzyme that can initiate transcription.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000006">
        <property type="protein sequence ID" value="PJN10130.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN10130">
        <property type="protein sequence ID" value="PJN10130"/>
        <property type="gene ID" value="CG723_19295"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050896">
        <property type="term" value="P:response to stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039425">
        <property type="entry name" value="RNA_pol_sigma-70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014305">
        <property type="entry name" value="RNA_pol_sigma-G_actinobac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013249">
        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037401">
        <property type="entry name" value="SnoaL-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43133">
        <property type="entry name" value="PTHR43133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08281">
        <property type="entry name" value="Sigma70_r4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12680">
        <property type="entry name" value="SnoaL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="SSF54427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02960">
        <property type="entry name" value="SigX5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="6">
        <location>
            <begin position="16"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4_2" evidence="7">
        <location>
            <begin position="135"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="domain" description="SnoaL-like" evidence="8">
        <location>
            <begin position="210"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF08281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF12680"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PJN10130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="330" mass="36348" checksum="33A69484224052FF" modified="2018-04-25" version="1">MSDIAGTTTEVDVRLEKYRVELTGYCYRMLGSAFEAEDAVQDTMVRAWRSFDKFEGRSSLRSWLYRIATNVCLDMLNAGNKRARPMDLTAAAPLAQAALTPRPDNVWLEPMPDARVLPTVHDPAEAAVARESVRLAFVAALQQLPAKQRAVLILREVLAWKAQEVAELLDTSVASVNSALQRARATLAEVPAEKTSADDELDEEHQALLERYVAAFEGYDMKALTALLAEDAIMTMPPFDLWLRGTPDITGFMTTIGASCADSRLVPVEANGSPAFAHYKPDPDKGGFSPWAVQVLEVSEGRITGLHCFLDTARYFPLFGMPLHLDDETA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JTM5</accession>
    <name>A0A2M9JTM5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MerR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_17670</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000005">
        <property type="protein sequence ID" value="PJN10224.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN10224">
        <property type="protein sequence ID" value="PJN10224"/>
        <property type="gene ID" value="CG723_17670"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000551">
        <property type="entry name" value="MerR-type_HTH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13411">
        <property type="entry name" value="MerR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00040">
        <property type="entry name" value="HTHMERR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00422">
        <property type="entry name" value="HTH_MERR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="SSF46955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50937">
        <property type="entry name" value="HTH_MERR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH merR-type" evidence="1">
        <location>
            <begin position="1"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN10224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="265" mass="28746" checksum="67ABF70990A35BB0" modified="2018-04-25" version="1">MRIGELAGMAGITTRAVRHYHRIGLLPEPPRQPNGYREYSLRDAVELARIRRLTELGLSLDEVKDVLADDVGKDLVEILTELDADLARQEEAIRQRRARLRLLLGQAEHTGELPAEAPVSPELAALFADMARASARLPGPEPAMAAKERELLALLETGSPGGDRGWLDALMHTLNADSDAMRRAYDVYAQLDELAEATEDDVRVEAAARAIVDSIPEAAARAMNIPADGDVGEDGGFADALFSDFAPAQAAAVRRAIALLQERAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-09-29" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JTZ2</accession>
    <name>A0A2M9JTZ2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cytochrome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_18300</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000005">
        <property type="protein sequence ID" value="PJN10333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN10333">
        <property type="protein sequence ID" value="PJN10333"/>
        <property type="gene ID" value="CG723_18300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002397">
        <property type="entry name" value="Cyt_P450_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00359">
        <property type="entry name" value="BP450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="SSF48264"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN10333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="410" mass="44632" checksum="232C8B18DA39A19A" modified="2018-04-25" version="1">MTDPTAAPLQLTHTQIDEASHGHDVPLVRVTLPGTTTPVWLATRYDVVKAALGDTRFVRDLAKVPGERGGGVGAELLDDAGLPPEYRQYLEILVMVDGPEHTRLRTHVMRAFAPRRIAALRPRIERIVQDVTGELVAKGDQFDLLSAFAYPVMTDVICEIIGVDAADRPKVSGWIRDYESGEPDRFLPGIDHLAEYIGGLLDLRGPAPKEDLVSDLLRSSATAAEGQRLTRQEMIALVFLLINTGIAPPAFFITDAVLTLLDHPQETVRLRAERDLLPRAVQELLRHVSAVRVGATLYATEDVELGGVLVRQGEGVTSGLLAANRDPGSFDDATRLDLTREVARGAGHIAYGHGAHRCIGAALANLQTEVILDELFLRRDSLELAVEREAVERVGFAGDGTYPIALPVRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-05-25" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JU27</accession>
    <name>A0A2M9JU27_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">LacI family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CG723_18690</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000005">
        <property type="protein sequence ID" value="PJN10391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN10391">
        <property type="protein sequence ID" value="PJN10391"/>
        <property type="gene ID" value="CG723_18690"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01392">
        <property type="entry name" value="HTH_LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000843">
        <property type="entry name" value="HTH_LacI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046335">
        <property type="entry name" value="LacI/GalR-like_sensor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00356">
        <property type="entry name" value="LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13377">
        <property type="entry name" value="Peripla_BP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00354">
        <property type="entry name" value="HTH_LACI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50932">
        <property type="entry name" value="HTH_LACI_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH lacI-type" evidence="5">
        <location>
            <begin position="23"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PJN10391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="353" mass="37466" checksum="366AF6863D50EF3B" modified="2018-04-25" version="1">MNSSTVQKKQTSASQEPSGGGTATLAEIAREAGVSAPTVSKVLNGRADVAPATRERVEELLRRHGYQRRRANSTAIPLLELVFHELDSSWSMEVIRGVENVAREEGLSLVLSEHAGQLSIGQSWVDGVLARRPTGVILVLSGLDAAQRAQLTSRDIPFVVMDPAGDPGDDVPAIGATNWQGGLAATRHLLELGHRRIGVIAGPAGMMCSRARIDGYRAALETAGVAFDPALIREGTFHHESGHAAGLELLGLPDRPTAVFAGNDLQALGLYEAAREMGLRIPDDVSVVGFDDLPLARWVGPPLTTVRQPLVEMAEAAARLTLDLARGKKPATLRMDLATSLVVRSSTAAPAER</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JU72</accession>
    <name>A0A2M9JU72_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_18880</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000005">
        <property type="protein sequence ID" value="PJN10424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN10424">
        <property type="protein sequence ID" value="PJN10424"/>
        <property type="gene ID" value="CG723_18880"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="23"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="47"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="86"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="116"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="146"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN10424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="170" mass="17372" checksum="E6152419597C8568" modified="2018-04-25" version="1">MAANVEKKGELLDTQRERLKERIYAAITMLAVVVGLAQSPHAEHWTAAAYVTGTAVGLWLATLVADVQAHRVVHKRFPGRAEARHMLYVSSPLLSSAAGPLAMDALSAAGALDLDTALWIAAGAGIAGIAAWGFEGGRRMGGGLLTSSLAAAADAVIGAGVVGVKLLAGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-05-25" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JUS9</accession>
    <name>A0A2M9JUS9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_15665</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ROK (NagC/XylR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000004">
        <property type="protein sequence ID" value="PJN10646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN10646">
        <property type="protein sequence ID" value="PJN10646"/>
        <property type="gene ID" value="CG723_15665"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000600">
        <property type="entry name" value="ROK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18964">
        <property type="entry name" value="PTHR18964"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00480">
        <property type="entry name" value="ROK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01125">
        <property type="entry name" value="ROK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="164"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="169"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN10646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="435" mass="44543" checksum="7E9332E79D6CC63C" modified="2018-04-25" version="1">MPSVMHPLKQRCCQSASGRDNGGVNRANSGVNLAVLRGHNAALVLDLLRTAGDEGISRLELAERTGLTPQGVSKITARLREQGLVTDTGRRASTGGKPRTVLRLVPDAGHAVGLHLDRDELTAVLVDLAGTVVAERRSPLAFGAGGDAVVEAAASEVEALLADADGGDADAGEPDRRDVRDPDVRDPDAQEPDAQDPVHPEPPTSRVLGVGVALPGPLDHSSGVLHRVTGFPEWDGFPLRDALAERLGLPVVVDKDTNAAALGLALAGSGDAFAYLHLGTGLGAGLVLGGAPYRGPHTGAGEFGHQVIQLDGPLCSCGNRGCIEALCLAAVAAGSFDEAARVLGEGAANMVGLLDIDLVLLGGRTVAAAEERFVGGVRAVLGERARRGGTVEVPVLRAPGAATAVVEGAAQLVLAPLFGRAHGHFPANRNDRNLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-05-25" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JUW0</accession>
    <name>A0A2M9JUW0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Decarboxylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_15840</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000004">
        <property type="protein sequence ID" value="PJN10675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN10675">
        <property type="protein sequence ID" value="PJN10675"/>
        <property type="gene ID" value="CG723_15840"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026286">
        <property type="entry name" value="MaiA/AMDase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40267">
        <property type="entry name" value="PTHR40267"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17645">
        <property type="entry name" value="Amdase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015736">
        <property type="entry name" value="MI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="253"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN10675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="272" mass="29700" checksum="0F86564E2E372BBD" modified="2018-04-25" version="1">MDVSFLGGPHPQRGVGVVAPFDFALDRELWRWVPDEVSLHLTRTPFVPVEVSLDLARLVSEHETLGEAVRALSAAEPEVLAYACTSGSFVGGIAGERAMCEAMFRSGERPSVTTSGALLEALTELGARRIALVTPYTRSVTESLEEYLAEAGITVTGRAFLGLTRHIWKVPYRDVADMARGAARQDADALFISCTNLPTYDVIPQLEAELRIPVISANQVTVWAALRRLGTRAVGPYQALLDESARHWPARELPQLPQEPAGELPEEQEGWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JUY2</accession>
    <name>A0A2M9JUY2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">2-aminoethylphosphonate ABC transporter substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_15695</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000004">
        <property type="protein sequence ID" value="PJN10652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN10652">
        <property type="protein sequence ID" value="PJN10652"/>
        <property type="gene ID" value="CG723_15695"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026045">
        <property type="entry name" value="Ferric-bd"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002825">
        <property type="entry name" value="CfbpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014987167" evidence="2">
        <location>
            <begin position="32"/>
            <end position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN10652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="353" mass="37631" checksum="366C1743C9606A20" modified="2018-04-25" version="1">MRRNMLKPIAAVTGSLALAATLSACGGNSAASDEKSVTVYSADGLKGENGDGWYDQVFKDFTKKTGIKVEYVEGGSGEMVQRAAREKSNTQADVIVTLPPFIQQADGKGLLAKYTPQGADQVDGADKAADGTWTSVVNNYFGFVYNKKDLKTAPTTWDELLDGKYKNKLQYSTPGVAGDGTAVVVKAMHDFGGKKPAMDYLKKLQANNVGPSASTGKLAPKVDKGELLVANGDVQMSFAQSKTMPNLGLWFPKKAGGKPTSFALPYAGGLVKNAPHSENGKKLLDFMLSTKAQQQVSSIGGGFSARKDVKATDENAIALSKVMDGVEIFEPDWNDIDKNLQTYVEDWKSATGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-05-25" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JV42</accession>
    <name>A0A2M9JV42_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Aldo/keto reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_16320</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000004">
        <property type="protein sequence ID" value="PJN10751.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN10751">
        <property type="protein sequence ID" value="PJN10751"/>
        <property type="gene ID" value="CG723_16320"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NADP_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="SSF51430"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldo_ket_red" evidence="1">
        <location>
            <begin position="7"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN10751.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="302" mass="32804" checksum="402F20E92C74D986" modified="2018-04-25" version="1">MGLGGSWDSAPFRPSDIDAAEAAVQAALDSGITAFDHADIYRDGKAEAVFGEVLARTPGLRERITVQTKCGIRLADGDRPGVYDLRGARIVRCVEESLTRLRTDHVDVLLLHRPDPLADPGDVAKALASLQEQGLVRSFGVSNMSAHQIAHLQAHLDFPLVANQLEMSLKSRDWVEAGVLVNTPDAASNGFPLGTLEHCAEHGIRLQAWGPLAQGSYTGREATPAEYATARLVADLAEKKHTTPETIILWWLQRHPSRIAPVIGTANPSRIRACADAARRAPELTHEEWYELWVTARGAALP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JV88</accession>
    <name>A0A2M9JV88_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_16650</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000004">
        <property type="protein sequence ID" value="PJN10805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN10805">
        <property type="protein sequence ID" value="PJN10805"/>
        <property type="gene ID" value="CG723_16650"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="286"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN10805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="376" mass="41214" checksum="C5BFC6F6549ED20C" modified="2018-04-25" version="1">MNHNTPLSPHPLQHLDDGRQRVLSAAQLKAHGVNSAALNEQCRPGGPWQQLLPGVYLLHPGRPTPDERLHAVLLYAGRPQTRTAVAVPTQTTPGEPHPPQAAPQAPYANAMVTGLAALALHRFVSVPPLLSLDRIDVMVPRTRRLRSTGIARLVRSHGMPTPQRISGVPVAPVPRALADAVAQLDDAGAVRRLLTEAVRDGHCEPAVVVRELNQARLLTRPHVIDAVDSLLAEGRAIAEDRMYEMVREYGLPDPLWNVDLRLPGGPHLGGVDAYWPDQAVAVELDTSPSSRIRSSNEGPNAPRHGLRPELQEESDGLEWSEYARKREHLERLGITVVHITPRKLRESLEQQATVVRTALMASVDREPAAYVMVLPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JVS7</accession>
    <name>A0A2M9JVS7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">DNA-binding response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CG723_17215</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000004">
        <property type="protein sequence ID" value="PJN10964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN10964">
        <property type="protein sequence ID" value="PJN10964"/>
        <property type="gene ID" value="CG723_17215"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="5">
        <location>
            <begin position="1"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="domain" description="HTH luxR-type" evidence="4">
        <location>
            <begin position="131"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PJN10964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="203" mass="21205" checksum="5D008313D1F398C0" modified="2018-04-25" version="1">MLVESAPDMEVVGQAGTGREAVEQARTRRADLIVMDIRMPDLDGIEATRLLAADEDLAGVKVLMLTTYDTDEHVVEALRAGASGFLVKDTKPAELLDAIRTVAAGESLLSPGPTARLIARVLRAPAEPGPVPPGLAALTGRESQVLTLVARGLTNTEAADVLGLSPLTVKTHVSRIMGKLGARDRAQLVIVAYESGLVEPGGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JVV5</accession>
    <name>A0A2M9JVV5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">FMN-binding glutamate synthase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CG723_08535</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CB01635</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the glutamate synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN11026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN11026">
        <property type="protein sequence ID" value="PJN11026"/>
        <property type="gene ID" value="CG723_08535"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015930">
        <property type="term" value="F:glutamate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006537">
        <property type="term" value="P:glutamate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02808">
        <property type="entry name" value="GltS_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024188">
        <property type="entry name" value="GltB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002932">
        <property type="entry name" value="Glu_synthdom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027283">
        <property type="entry name" value="YerD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01645">
        <property type="entry name" value="Glu_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006429">
        <property type="entry name" value="GOGAT_lg_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF500060">
        <property type="entry name" value="UCP500060"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014929076" evidence="3">
        <location>
            <begin position="32"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="domain" description="Glu_synthase" evidence="4">
        <location>
            <begin position="155"/>
            <end position="470"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRNR" id="PIRNR006429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PJN11026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="527" mass="56818" checksum="6220E11C59F5F8F7" modified="2018-04-25" version="1">MTRFATVGLLTACALGSLLLTVSASQWWWFAAAPLTAAALTGVYDLVQRRHSVLRNYPVLGHLRFLMERLRPELQQYFVERNYDGRPFDRDTRSIVYERAKGVAAEEPFGSERDMNDRGYEFLVPSMAPVDVPDTPPRVGIGGPDCTEPYDMALLNVSAMSFGSLSANAVVALNTGAARGGFAHDTGEGGLSTYHLRPGGDLVWEIGTGYFGCRTSDGGFDARQFAEKAAHPSVRCVSLKLSQGAKPGIGGVLPGSKVNAEIASVRGVPEGETIVSPPYHRVFSTPRELVRFLARMRELARGKPVGFKLCPGSRTQFLAVCKAMREEGITPDFIVVDGAEGGTGAAPLEFADHLGMPLTDGLFTVHSALTGAGLRERIRIGASGKVATGADIVKRLAMGADYTNAARAMMFAVGCIQAQRCHTNDCPTGVTTQDPRRARALDVVDKAARVASYQQATVDSALQIMAAMGVRDTAELGPRLLRRREDHGGFRSYAELYEWLSPGELLAEPPESWATDWQAADPDTFAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JVY9</accession>
    <name>A0A2M9JVY9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_08790</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN11061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN11061">
        <property type="protein sequence ID" value="PJN11061"/>
        <property type="gene ID" value="CG723_08790"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="15"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="105"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN11061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="201" mass="20851" checksum="0778DD3A02BD0B6F" modified="2018-04-25" version="1">MRLYAQTPARRSRQILADLIAAALIYAAVKLALVVHDAIGRLADPGRKAESAGNSLSDGLVDAGDAASKVPFVGGQLKKQLGSAAEAGTGLADAGRSLQDTVGHVATLTTVVLIVIPVVFVLLLWLPPRLRWIRRSAVTRRLAADPGGADLLALRVLTGSQRALAAVPAPPGGLAEAWRRGDEQVIADLAAIGLRQAGLRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JVZ9</accession>
    <name>A0A2M9JVZ9_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PLD phosphodiesterase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_08590</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN11034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN11034">
        <property type="protein sequence ID" value="PJN11034"/>
        <property type="gene ID" value="CG723_08590"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025202">
        <property type="entry name" value="PLD-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001736">
        <property type="entry name" value="PLipase_D/transphosphatidylase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13091">
        <property type="entry name" value="PLDc_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50035">
        <property type="entry name" value="PLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014780113" description="PLD phosphodiesterase domain-containing protein" evidence="1">
        <location>
            <begin position="24"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="domain" description="PLD phosphodiesterase" evidence="2">
        <location>
            <begin position="338"/>
            <end position="373"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN11034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="434" mass="46638" checksum="846BA5D2A0521EC1" modified="2018-04-25" version="1">MKRTFTSITALVVTALSLTTAQAAVKKAKPPLSCESRPFTSSPGPRFNDPEDPAAQMKIMGPIIESINSASCGQTIRVAMYSISNAQPGPDFANALIAAHQRGVIVKALMDSHSDNAIWQSMVTELGNDPRASSFAALCPGGCLTHYAGSSLHAKYYMLSGGSDANRTVTVSSANPTAAQASTAWNSSATVKGNVDLYNSYVSYFTAMAKGALNGPGPLAPDYYSSTSATAARKLSPPSYQWPKARAKSDTWVDFLGNIKAPATINIAMFQWTSHGEPGDRNYLELPKKLVSLAGTGVKIHILITAGQVDGSVQNYLKNRPNIDVHDTTRGTDANGNALHYTHNKYMMVSGNYAGAANSKLVFVGSSNWTSNGVWHNDETDLKLTGGSNYDTFMTDWQSQYDRCCGTAERQSIAEKRAENTAREIPIDPRQVQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JW78</accession>
    <name>A0A2M9JW78_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Taurine dioxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CG723_09310</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN11146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN11146">
        <property type="protein sequence ID" value="PJN11146"/>
        <property type="gene ID" value="CG723_09310"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042098">
        <property type="entry name" value="TauD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003819">
        <property type="entry name" value="TauD/TfdA-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02668">
        <property type="entry name" value="TauD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TauD" evidence="3">
        <location>
            <begin position="50"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PJN11146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="314" mass="35740" checksum="AFEF8B73F9484F4F" modified="2018-04-25" version="1">MSLTHDVAPASALRDHRIPADGLYEGSRILNRLPDGVRERPYERFELVPQGRVIGAEIRGLDLSRPVSCAVREELNRALLEWKVLFFRGQHLTSDAQRQFARNWGELETNPLLAPGDADDVVRFDKSAGAVPTFENVWHTDVTFRERPALGAVLQLREVPPVGGDTMWADMAAAYDNLPVEVRERIDGASAVHDFLPGFARFYAPEQLAPFQKQFPPVQHPVVRRHPETGRRMLFVNTSFTTRIIGLERPESDRLLRLLFQQAHVPEFQVRFRWQAGDVAFWDNRATQHYAVNDYAPYPRVAERVAIAGDRPFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-05-25" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JWA6</accession>
    <name>A0A2M9JWA6_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Peripla_BP_6 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CG723_09515</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN11176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN11176">
        <property type="protein sequence ID" value="PJN11176"/>
        <property type="gene ID" value="CG723_09515"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028081">
        <property type="entry name" value="Leu-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13458">
        <property type="entry name" value="Peripla_BP_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014657308" description="Peripla_BP_6 domain-containing protein" evidence="2">
        <location>
            <begin position="30"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="domain" description="Peripla_BP_6" evidence="3">
        <location>
            <begin position="103"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="56"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="74"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PJN11176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="463" mass="46348" checksum="686EEE37061700F9" modified="2018-04-25" version="1">MIPTRTRATAAAVAALSLVLAACGSRVDHDTVVRSVGGGGQVATGAAGADTTVGADGSADATSGEAASGDAASGSGAGTGNGSSSGGSASGSGGKTTKGGGGPIVIGSVGTTSGPGGVAFAQGPRALQAWAATVNAQGGINGRKVQVIVMDDGADASKGRSQMQELVEQRKVVAIVASFTTTQTMNAWKSYVEKKKVPVVGGDCSTTAWTASPMLFSECPGTNSALDGLAQVGAKYGKGKKLGALFCTDSEACTHVQDRFFGSGKAAERYGLDPVYNAKISVTQPDFTAECIQARNAGVELMLVTGDPNTVNRVASSCSRQNFTPQFLQPGATVDGATASKPGLKDVLAVTPAFPFTGSAAAGFGQFDSAWNKYGGGKAPGPAAAQGWASAKVFEKAARGAGEISRAGLIKELTTFRGQRFDGLTVPLTYVAGKGTTDTKCAFGMRGSGGRWTAMSGGKAFCW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-09-29" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JWB9</accession>
    <name>A0A2M9JWB9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CG723_09600</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CB01635</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN11191.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN11191">
        <property type="protein sequence ID" value="PJN11191"/>
        <property type="gene ID" value="CG723_09600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="72"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="100"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="124"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="158"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="188"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="263"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="300"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="328"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="352"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="387"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="417"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="7">
        <location>
            <begin position="34"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="447"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="449"/>
            <end position="486"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PJN11191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="486" mass="50222" checksum="6E40C160B1C5CB7F" modified="2018-04-25" version="1">MAASPGSPDAVAAPSPAGASPNSSRTSSRAGWLITLYAGGGEFCDGYILSIIGVALPLVTSAFQLGPGGAGLIGSASLVGMFAGGLAFGYVTDRIGRRKVYLAAMAAFIVLSALQYGADAAWQLVVLRFLMGVAIGADFAIAGTIAAEFAPERSRGPLMVVLVTMWSAGAAVAYAVGWLMLRSGLDDWRLLLASSAVPATVVLLFRLRTPESPQWLLSRGRIEEARAVLRRMGGDVGAAVAPVRPAVTPRYSDIFRNGYGRRTLFVCLFWCCQLLPIYAITTYEPTILASFGLGEGTDSYLGAVAVQLFFVLGSLSGMLMVNRGRRALLLWSFGASVLPLTGLAAVADPPVWLVVLLFAVFGVTAFASQCLQALYPSELFPTEVRATANGFAAGVSRVGAAIGTFGAPVLLGHSTHLAMLVGAGIALAGWLATLLLAPETRGLSLDEAATSGEPTSSLGPALSLSAPTPTVASISSTPSTEVTDLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JWK2</accession>
    <name>A0A2M9JWK2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CG723_09635</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN11198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN11198">
        <property type="protein sequence ID" value="PJN11198"/>
        <property type="gene ID" value="CG723_09635"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020037">
        <property type="entry name" value="DUF4312"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14189">
        <property type="entry name" value="DUF4312"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PJN11198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="111" mass="12587" checksum="3E8EF15859CA2266" modified="2018-04-25" version="1">MIEDRHTVRVSGTGPTREKAFAAAMQQVSGAVGKLTDGVCFRVEPLAVEVASAVEHRWTERFLGLLFARERRRYELTLRIEVRTAALDLDAIAFSVREERLTPLQHALHMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JWL0</accession>
    <name>A0A2M9JWL0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">TetR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_09260</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN11137.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN11137">
        <property type="protein sequence ID" value="PJN11137"/>
        <property type="gene ID" value="CG723_09260"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="14"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="37"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN11137.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="217" mass="23755" checksum="3FE24BE008221120" modified="2018-04-25" version="1">MAATHIDGRVARGNQTRQLVLKRAMQVASVEGLEGLSLGRLAGELKLSKSGVFALFGSKEDLQLATVRAAIKVFLEHVVQPARELPPGINRLWRVCTSWLTYSRERVFSGGCFFYSTSAEYDARAGKVHDTLAAARTDWSTYLEQTIVEAQQTEEIAEDIDVPQLAFELVALLEMANAESVLHDEFTSYDKAATAILNRLRGAATDPSLLPGTIDGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JWP4</accession>
    <name>A0A2M9JWP4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Mechanosensitive ion channel protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CG723_09910</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CB01635</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MscS (TC 1.A.23) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN11242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN11242">
        <property type="protein sequence ID" value="PJN11242"/>
        <property type="gene ID" value="CG723_09910"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006685">
        <property type="entry name" value="MscS_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011066">
        <property type="entry name" value="MscS_channel_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011014">
        <property type="entry name" value="MscS_channel_TM-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023408">
        <property type="entry name" value="MscS_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00924">
        <property type="entry name" value="MS_channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="SSF50182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82689">
        <property type="entry name" value="SSF82689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82861">
        <property type="entry name" value="SSF82861"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="85"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="116"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="146"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PJN11242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="357" mass="38164" checksum="CF00386409925727" modified="2018-04-25" version="1">MNRAMTPDDLIVAGIAIAAGLAAGLLLRMMLRWLGVRADRTRWGGDDVIVDALRSLVPWAAVAAGAAVAASALPLTTRTRHNVTVTLTALLILVATFTAGRVISGLVRSVAQSRSAVAGSATIFVNITRVVVLAVGFLVVLQTLGISIAPLLTALGVGGLAVALALQDTLANLFAGVHILASKTVQPGDYIRLSSAEEGYVVDINWRNTVVRQLSNNLVIIPNAKLASTNMTNYSRPEQEMTLLVQVGVGYDSDLEHVERVTAEVVESVMVDITGAVPDHEPAIRFHTFGDSRISFTVILGVGEFSDQYRIKHEFIKRLHARYRDEGIRIPAPTRTVALQQGAVAIPHQREAAPPIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JWU3</accession>
    <name>A0A2M9JWU3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Sphingomyelin phosphodiesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">sph</name>
        <name evidence="3" type="ORF">CG723_10595</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN11365.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN11365">
        <property type="protein sequence ID" value="PJN11365"/>
        <property type="gene ID" value="CG723_10595"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008081">
        <property type="term" value="F:phosphoric diester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09078">
        <property type="entry name" value="nSMase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017766">
        <property type="entry name" value="Sphingomyelinase/PLipase_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03372">
        <property type="entry name" value="Exo_endo_phos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="SSF56219"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03395">
        <property type="entry name" value="sphingomy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014734758" evidence="1">
        <location>
            <begin position="32"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="domain" description="Endo/exonuclease/phosphatase" evidence="2">
        <location>
            <begin position="58"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN11365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="327" mass="35009" checksum="47087BB0F09717F1" modified="2018-04-25" version="1">MSRVARRTTGSALAVTLAAASAVLTAPQASAATSADTPRLKVLTYNTFLMSTNLYPNWGQAHRAAAIPAAPFFQGNDVVVLQEAFDNTTSDALKSNAAAQYPYQTPVVGRSKDGWDATGGSYSSTTPEDGGVTLLSKWPIVHKEQYVYKDACGSDWWSNKGFVYAVLDVNGAKVHVVGTHTQSTDSGCGAGEAVKDRSLQFKAIKSFLDAKHIPAGEQVMVAGDLNVDSHGTEYASMLADGGLVGADSRTGHPYSFDTEANSIASYRYPGEPKEDLDYVLHVQGHARPTGWVNNVVKETTSPWTVSSWGTSYTYNNLSDHYPLQAGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JY87</accession>
    <name>A0A2M9JY87_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Peptide ABC transporter substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_13490</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN11845.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN11845">
        <property type="protein sequence ID" value="PJN11845"/>
        <property type="gene ID" value="CG723_13490"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042597">
        <property type="term" value="C:periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030678">
        <property type="entry name" value="Peptide/Ni-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039424">
        <property type="entry name" value="SBP_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000914">
        <property type="entry name" value="SBP_5_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30290">
        <property type="entry name" value="PTHR30290"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00496">
        <property type="entry name" value="SBP_bac_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002741">
        <property type="entry name" value="MppA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014747727" evidence="1">
        <location>
            <begin position="23"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="domain" description="SBP_bac_5" evidence="2">
        <location>
            <begin position="90"/>
            <end position="459"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN11845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="538" mass="58554" checksum="5CB4CEC95D3D921C" modified="2018-04-25" version="1">MMRRALPVIGLVLTLAACTSGAQQPRQGAAPAKLDLKTTTPAATKGLGKVTWNLPYEPQTLDPIRSFNYAENTALANMCESLLRLTPDFKIKPGLAVKAANPTPTTWVYTIRKGVTFWNGDPLTADDVAASLRRHLDPKLGTWWGDYFNTVKSVRATDSMQVTVTLKQPDALFNQAMATGAGAVVQKKFLDKAGKSLGSPSSGVMCTGPFRFHDWKSGDSMTLRRYDHYWNKPLKAKSESLVLRFIADETTAVNALRSGEVDGQYFYLPPAGLSQLQKSTTGSVTLGRSLTFWALLSSAKSGPYADPRVRQALSLALDRAAISKVVFQGTASPQRALTGSDYWGYERKTYQKAYEALPPETTDLAKAKELLVQAGSPTKPIVIGVQGSSAVHEQTANLLKATGEALGLDIEIRVVPVEQYGNLYSDPKARKGIDAFLSTWYGNVPDPLDIYTVFRKGGRTNFSDYKAVDGAIAKARAEGDPAARASLVTGIQEKVTRDVVWMPLNNLPVILYMNKRVTGAVPSFPYLYYPWAAGLGAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JY97</accession>
    <name>A0A2M9JY97_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CG723_13415</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN11834.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN11834">
        <property type="protein sequence ID" value="PJN11834"/>
        <property type="gene ID" value="CG723_13415"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041289">
        <property type="entry name" value="Bact_RF_family3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029064">
        <property type="entry name" value="L30e-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18845">
        <property type="entry name" value="baeRF_family3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55315">
        <property type="entry name" value="SSF55315"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PJN11834.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="393" mass="43880" checksum="A334362DC1CBDC73" modified="2018-04-25" version="1">MHTSDLTPEIRAALSKKRPYPAITLVTPTDPDFPFSDKDRILIRDLVTEAKRRLVDDPDVERETRLELRDQLLDPAEIERATDPFHPDDAMVVYVAVNEPVQVWRMTSLAPVEPRVEFGTAFLTRYLVAAEQRSRPYLVLVLDQEMCRLYHGSVRRLQEVEKNGWPDKPQIPSPEDAIPGSIPHSTPYEGHEERVEQYLRTVDKRLGQSFEEHDGLPLFVIGGDKILSTFKSITRYGNLIAGSLPLTGMDKESAQDLEKRLQPVLADFYAKQVAEAVSELSEARGQGKYVGGAPEVWTSVADKRVHRLVVEEGLMLAGRITEDDRVLELVDVPKPVTLPDPKKDMEPSAHALGVATDIVERLVDNAIAADARVLFVPDGTLPEAGGVAALLRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JYQ8</accession>
    <name>A0A2M9JYQ8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_14450</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN12005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN12005">
        <property type="protein sequence ID" value="PJN12005"/>
        <property type="gene ID" value="CG723_14450"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012551">
        <property type="entry name" value="DUF1707"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08044">
        <property type="entry name" value="DUF1707"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN12005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="219" mass="23570" checksum="B8E5B83370F38AAC" modified="2018-04-25" version="1">MSGEISPTGKRSGPGSPPELRASHADRDRVVDVLRIAAGDGLLTADELDERLEVALSARTLSELAALTADLPPASATVGGTGAGVKDVVRIEQVHSGAVERVGRWVVPRRLELAVTYCEVMLDFTDAVITHDTLRIDVGMTGKTLTLVTRPGVVVDIDALQLVHSRVKYRHTPTNPDTPVTLRVELAGQKAHGRVVVRPPRRTFGQWLLRRPPPPSPGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JYW0</accession>
    <name>A0A2M9JYW0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glutamine amidotransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_14810</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN12065.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN12065">
        <property type="protein sequence ID" value="PJN12065"/>
        <property type="gene ID" value="CG723_14810"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002818">
        <property type="entry name" value="DJ-1/PfpI"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01965">
        <property type="entry name" value="DJ-1_PfpI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DJ-1_PfpI" evidence="1">
        <location>
            <begin position="112"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN12065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="229" mass="23547" checksum="630553832FE17815" modified="2018-04-25" version="1">MHAQIVLFDGFDPLDAIGPYEVLYAGGTASGGAVSVELVSAEGPREVVSGTGGLVLRATAALDPTRAGLILVPGASGRVGEPGEVPDHDAGAGEWQRDEFIPVLLGRTLTTELPALLKAAMDNPEVTVGAVCGGSLVLAMADLLEGRHATTHHLGLDMLDATGVHAVSARVVDDGDLVTGAGVTSGLDLGLYLLEREVGPQIAHAVEELFAHERRGTVWRHHGPAPVGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JZE9</accession>
    <name>A0A2M9JZE9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Sugar kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_04085</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ROK (NagC/XylR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000002">
        <property type="protein sequence ID" value="PJN12251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN12251">
        <property type="protein sequence ID" value="PJN12251"/>
        <property type="gene ID" value="CG723_04085"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000600">
        <property type="entry name" value="ROK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18964">
        <property type="entry name" value="PTHR18964"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00480">
        <property type="entry name" value="ROK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01125">
        <property type="entry name" value="ROK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN12251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="420" mass="42925" checksum="D6C280431A38B42D" modified="2018-04-25" version="1">MAGDRTRERPRSQTSAGDLLDLVRSGRATTRGALQEATGLSRATVGQRLDRLFRAGWLREGAGGPAGSPTGGRPSLRLEFDDAHAVVLAVSLDTRHARAAVLTLTGELLAERSGALSVDEGPERVLGALGGWFAGLLKEAGRTADAVCGIGIGVPGPVDSATGRVVQPPIMPGWDGYDIRGRLGRAFAEQTGGGGDVRDAGGAEGAGGVPVLVDNDANLMAYGEQRTGHPDCAAFALVKVSTGIGAGVVVGGRIYRGIDGGAGDIGHIRVPEGAGTLCRCGSYGCLASVASGRALARRLTEAGVPAESGSDVRELLAEGHPEAVRLAREAGRSVGEVLATVVTLLNPGVLMIAGDLAGTPFLTGVRELLYQRALPRSTAHLDVVTARLGERSALVGAGALVVEHLYAPDRAEERLAALGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JZR5</accession>
    <name>A0A2M9JZR5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">HAD family hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CG723_04650</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000002">
        <property type="protein sequence ID" value="PJN12348.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN12348">
        <property type="protein sequence ID" value="PJN12348"/>
        <property type="gene ID" value="CG723_04650"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024197">
        <property type="entry name" value="UCP030802"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF030802">
        <property type="entry name" value="UCP030802"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PJN12348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="277" mass="30097" checksum="EC925B109D4F71E0" modified="2018-04-25" version="1">MSATPVTLVASDLDRTLIYSAAALGLTMPDAQAPRLLCVEVYEGKPLSYVTEDAAELLGELGRSALFVPTTTRTREQYGRIHLPGPVSQFAICANGGHLLVDGVSDPDWRAAVDERLAAECAPLDEVRAHLVRTADPAWLLKERVAEDLFAYLVVDRSLLPEGWVKELAVWAERRGWTVSLQGRKIYAVPKPLTKSAAMHEVARRSGADLTLAAGDSLLDADLLLAADHAWRPGHGELADAGWTAPHVTALEDRGVAAGETILRELVDRVRQPRTYP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-06-02" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JZY8</accession>
    <name>A0A2M9JZY8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Iron transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CG723_05285</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CB01635</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the oxidase-dependent Fe transporter (OFeT) (TC 9.A.10.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000002">
        <property type="protein sequence ID" value="PJN12452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN12452">
        <property type="protein sequence ID" value="PJN12452"/>
        <property type="gene ID" value="CG723_05285"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033573">
        <property type="term" value="C:high-affinity iron permease complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005381">
        <property type="term" value="F:iron ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004923">
        <property type="entry name" value="FTR1/Fip1/EfeU"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31632">
        <property type="entry name" value="PTHR31632"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03239">
        <property type="entry name" value="FTR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="38"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="70"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="108"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="146"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="179"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="243"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PJN12452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="285" mass="30573" checksum="1C1D584387E9D7B6" modified="2018-04-25" version="1">MFGNYLIGLREGLEASLVVCILIAYLVKTDRRDALRPIWIGIAIAVAVALGFGFALTFGSQELTFEAQEALGGSLSIVAVGLVTWMVFWMRRTARHLKAELHGKLDAALQMGTAALVATAFLAVGREGLETALFVWASVRASNDGTHGPLIGVLLGLLTAVVLGWLFYRGALRINLAKFFTWTGGMLVIVAAGVLAYGVHDLQEAQFLGGLSSKAFDISGTIPPDSWYGTLLKGVFNFQPDPTVLQVVVWLLYLAVTLTVFFAPSGFLSRKPEPEAQTPAESAKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K082</accession>
    <name>A0A2M9K082_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CG723_05630</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000002">
        <property type="protein sequence ID" value="PJN12514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN12514">
        <property type="protein sequence ID" value="PJN12514"/>
        <property type="gene ID" value="CG723_05630"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009351">
        <property type="entry name" value="YcaQ-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06224">
        <property type="entry name" value="HTH_42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PJN12514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="411" mass="44474" checksum="B09E00DA6C39EB10" modified="2018-04-25" version="1">MGARSDEQPWEVLVSGRRRHIGAPERRARLAAGQRLAPAARAGSAEEVAGSLVALHGTDPATVYLAVGARLRDPSKTVADVERALYTDRSLVRMHGMRHTVFVFPATLTAVVHASTGVAVAARERASFVKHLEAGSEHDAAWLADVEAGTLAAIGARGEATAAELAEDEPRLRTQLLYAPGKKYEAWQSISTRLLRVLGMEGRVVRGRPRGSWTSSQFRWALMPAHPELPVAEAQSELLRRRLGSCGPATEADLKWWTGWKVTDVRRALAAVGAVEVELDEGAGFVLPDAVEPVTADTEPWAALLPGLDPSPMGWQQRDWYLPPELRAPLFDGAGNIGPTVWWDGRIAGGWAQGRDGVVRWRLLADVGREGAAAVEASAARLQEWVGEARVTPRFRTPLEKELAGPAPARK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K0G0</accession>
    <name>A0A2M9K0G0_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Phospho-2-dehydro-3-deoxyheptonate aldolase</fullName>
            <ecNumber evidence="3">2.5.1.54</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CG723_06060</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CB01635</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>D-erythrose 4-phosphate + H2O + phosphoenolpyruvate = 7-phospho-2-dehydro-3-deoxy-D-arabino-heptonate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:14717"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16897"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58394"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="EC" id="2.5.1.54"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 1/7.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the class-II DAHP synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.54" evidence="3"/>
    <dbReference type="EMBL" id="NNBL01000002">
        <property type="protein sequence ID" value="PJN12594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN12594">
        <property type="protein sequence ID" value="PJN12594"/>
        <property type="gene ID" value="CG723_06060"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00053">
        <property type="reaction ID" value="UER00084"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003849">
        <property type="term" value="F:3-deoxy-7-phosphoheptulonate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009073">
        <property type="term" value="P:aromatic amino acid family biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008652">
        <property type="term" value="P:cellular amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009423">
        <property type="term" value="P:chorismate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002480">
        <property type="entry name" value="DAHP_synth_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21337">
        <property type="entry name" value="PTHR21337"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01474">
        <property type="entry name" value="DAHP_synth_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01358">
        <property type="entry name" value="DAHP_synth_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="3" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU363071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PJN12594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="450" mass="49624" checksum="BAF267DF7F3B3F1E" modified="2018-04-25" version="1">MTVNAKTSASAGNTWRNLPAAQQPEYPDAEALRDVIADLESYPPLVFAGECDQLRARLAAVAKGEAFLLQGGDCAEAFDAVSADHIRNKLKTLLQMGAVLTYAASVPVVKVGRIAGQYSKPRSKGTETRDGVTLPTYRGDSVNGFEFNEKARIPDPERLKRMYNASASTLNLVRAFTTGGYADLRQVHAWNQDFVKSSPSGQRYEQLAREIDNALNFMRACGTDPAEFQTVEFYSSHEALLLDYESALTRVDSRTGTLYDVSGHMVWIGERTRQLDGAHIEFASKIRNPIGIKLGPTTTPEEALQYIERLDPDGEPGRLTFIVRMGADKVRDKLPELVEKVTASGATVGWITDPMHGNTYEAASGHKTRRFDDVLDEVKGFFEVHKALGTHPGGIHVELTGDDVTECVGGGDEIFVDDLHQRYETACDPRLNRSQSLDLAFLVAEMYRDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K0G3</accession>
    <name>A0A2M9K0G3_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate ligase</fullName>
            <ecNumber evidence="7">6.3.2.13</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Meso-A2pm-adding enzyme</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Meso-diaminopimelate-adding enzyme</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">UDP-MurNAc-L-Ala-D-Glu:meso-diaminopimelate ligase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">UDP-MurNAc-tripeptide synthetase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">UDP-N-acetylmuramyl-tripeptide synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">murE</name>
        <name evidence="13" type="ORF">CG723_06215</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">CB01635</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>ATP + meso-2,6-diaminoheptanedioate + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamate = ADP + H(+) + phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D-glutamyl-meso-2,6-diaminoheptanedioate</text>
            <dbReference type="Rhea" id="RHEA:23676"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57791"/>
            <dbReference type="ChEBI" id="CHEBI:83900"/>
            <dbReference type="ChEBI" id="CHEBI:83905"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.2.13"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="7 8">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7 8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="7">Carboxylation is probably crucial for Mg(2+) binding and, consequently, for the gamma-phosphate positioning of ATP.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the MurCDEF family. MurE subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.13" evidence="7"/>
    <dbReference type="EMBL" id="NNBL01000002">
        <property type="protein sequence ID" value="PJN12623.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN12623">
        <property type="protein sequence ID" value="PJN12623"/>
        <property type="gene ID" value="CG723_06215"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008765">
        <property type="term" value="F:UDP-N-acetylmuramoylalanyl-D-glutamate-2,6-diaminopimelate ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007049">
        <property type="term" value="P:cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00208">
        <property type="entry name" value="MurE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036565">
        <property type="entry name" value="Mur-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004101">
        <property type="entry name" value="Mur_ligase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036615">
        <property type="entry name" value="Mur_ligase_C_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013221">
        <property type="entry name" value="Mur_ligase_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000713">
        <property type="entry name" value="Mur_ligase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035911">
        <property type="entry name" value="MurE/MurF_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005761">
        <property type="entry name" value="UDP-N-AcMur-Glu-dNH2Pim_ligase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01225">
        <property type="entry name" value="Mur_ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02875">
        <property type="entry name" value="Mur_ligase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08245">
        <property type="entry name" value="Mur_ligase_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53244">
        <property type="entry name" value="SSF53244"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53623">
        <property type="entry name" value="SSF53623"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63418">
        <property type="entry name" value="SSF63418"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01085">
        <property type="entry name" value="murE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 7 8" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2 7 8" id="KW-0132">Cell division</keyword>
    <keyword evidence="3 7 8" id="KW-0133">Cell shape</keyword>
    <keyword evidence="6 7 8" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 13" id="KW-0436">Ligase</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4 7 8" id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mur_ligase" evidence="10">
        <location>
            <begin position="84"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="domain" description="Mur_ligase_M" evidence="12">
        <location>
            <begin position="171"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="domain" description="Mur_ligase_C" evidence="11">
        <location>
            <begin position="392"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="71"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="UDP-MurNAc-L-Ala-D-Glu binding" evidence="7">
        <location>
            <begin position="214"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Meso-diaminopimelate binding" evidence="7">
        <location>
            <begin position="467"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Meso-diaminopimelate recognition motif" evidence="7">
        <location>
            <begin position="467"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="30"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="90"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:83900"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="173"/>
            <end position="179"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="241"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:83900"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="249"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:83900"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="443"/>
        </location>
        <ligand>
            <name>meso-2,6-diaminoheptanedioate</name>
            <dbReference type="ChEBI" id="CHEBI:57791"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="523"/>
        </location>
        <ligand>
            <name>meso-2,6-diaminoheptanedioate</name>
            <dbReference type="ChEBI" id="CHEBI:57791"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="527"/>
        </location>
        <ligand>
            <name>meso-2,6-diaminoheptanedioate</name>
            <dbReference type="ChEBI" id="CHEBI:57791"/>
        </ligand>
    </feature>
    <feature type="modified residue" description="N6-carboxylysine" evidence="7">
        <location>
            <position position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF02875"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF08245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PJN12623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="554" mass="57897" checksum="1D902ACA670B8B93" modified="2018-04-25" version="1">MTTITPDPGNQPAPRPSLRSMGGAPGTLTAVPQADQSQATQKGAPVTYPGPPRPVQVTATRLADLADQLGVPAPEEPTASTGSTGITHDSRAVRPGDIYAALPGARFHGADFAAQAASLGAVAALTDPSGAERVEAAGLPALVVENPRGRMGELAATIYGHPGRDLLQIGITGTSGKTTTAYLIEGGLRTMRSTGLIGTVEMRIGDERIKSERTTPEATDLQALFAVMRERGVDAVAMEVSSHALVLGRVDGCVFDVAVFNNLSPEHMEFHSDMEDYFRAKAQLFTRARSKQGVVNFDDEYGRRLVGESEVPVVTFSAEGHPDADWRAEDVEVGPFDSAFVAVGPKGERVTAKSPLAGPFNVANALAAIVALAAAGIDPQQAADGVAAVPGVPGRLERVDAGQPYLAVVDYAHKTDAVESVLRALRKVTENRLHIVLGCGGDRDITKRMPMGAAAARLADTAVLTSDNPRSEDPLAILATMLAGAAEVPAHERGEVQVFEDRAAAIAAVVARAQPGDTVLIAGKGHEQGQDIAGVVRPFDDRLVLREAIQQTQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K0I2</accession>
    <name>A0A2M9K0I2_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 7">UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase</fullName>
            <ecNumber evidence="6 7">6.3.2.10</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">D-alanyl-D-alanine-adding enzyme</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">murF</name>
        <name evidence="11" type="ORF">CG723_06220</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CB01635</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6 7">Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 7">
            <text>ATP + D-alanyl-D-alanine + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D-glutamyl-meso-2,6-diaminoheptanedioate = ADP + H(+) + phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine</text>
            <dbReference type="Rhea" id="RHEA:28374"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57822"/>
            <dbReference type="ChEBI" id="CHEBI:61386"/>
            <dbReference type="ChEBI" id="CHEBI:83905"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.2.10"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="6 7">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6 7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the MurCDEF family. MurF subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.10" evidence="6 7"/>
    <dbReference type="EMBL" id="NNBL01000002">
        <property type="protein sequence ID" value="PJN12624.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN12624">
        <property type="protein sequence ID" value="PJN12624"/>
        <property type="gene ID" value="CG723_06220"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047480">
        <property type="term" value="F:UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008766">
        <property type="term" value="F:UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate-D-alanyl-D-alanine ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007049">
        <property type="term" value="P:cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02019">
        <property type="entry name" value="MurF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036565">
        <property type="entry name" value="Mur-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004101">
        <property type="entry name" value="Mur_ligase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036615">
        <property type="entry name" value="Mur_ligase_C_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013221">
        <property type="entry name" value="Mur_ligase_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000713">
        <property type="entry name" value="Mur_ligase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035911">
        <property type="entry name" value="MurE/MurF_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005863">
        <property type="entry name" value="UDP-N-AcMur_synth"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01225">
        <property type="entry name" value="Mur_ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02875">
        <property type="entry name" value="Mur_ligase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08245">
        <property type="entry name" value="Mur_ligase_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53244">
        <property type="entry name" value="SSF53244"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53623">
        <property type="entry name" value="SSF53623"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63418">
        <property type="entry name" value="SSF63418"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01143">
        <property type="entry name" value="murF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 6 7" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="1 6 7" id="KW-0132">Cell division</keyword>
    <keyword evidence="2 6 7" id="KW-0133">Cell shape</keyword>
    <keyword evidence="5 6 7" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 11" id="KW-0436">Ligase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3 6 7" id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mur_ligase" evidence="8">
        <location>
            <begin position="34"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="domain" description="Mur_ligase_M" evidence="10">
        <location>
            <begin position="108"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="domain" description="Mur_ligase_C" evidence="9">
        <location>
            <begin position="318"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="109"/>
            <end position="115"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU004136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02875"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF08245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PJN12624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="470" mass="48912" checksum="42F9724DC362AA0C" modified="2018-04-25" version="1">MIALSLAEIATVVGGQTYDIPDPSVQVTGPVVRDSREVEPGSLFVAFVGERVDGHDYAAAVVAAGAAAVLASRPVGVPAIVVDDVQAALGALARTVVERLGATLVALTGSAGKTSTKDLIAQVLRRKAPTVFTPGSFNNEIGLPLTALSATDDTRYLVLEMGARGKGHIRYLTGLTPPRVGVVLNVGTAHIGEFGGREQIAEAKGELVESLPADGTAILNADDPLVRAMASRTKAKVLLFGEGADADVRAENVRLTENGQPSFSLRTPSGCSDVTLRLYGEHHVSNALAAAAVAHDLGMSVEEIALALSEAGTLSRWRMEVTERPDGVTVVNDAYNANPESMRAALRALAAMGRGRRTWAVLGHMAELGDEALAEHDAVGRLAVRLNVSKLVAVGGREASWLQLGAYNEGSWGEESVHVSDAQAAVDLLRSELRPGDVVLVKASRSVGLESVAQALLAVDGDNVGEVAAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K1B0</accession>
    <name>A0A2M9K1B0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glucoamylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_07825</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000002">
        <property type="protein sequence ID" value="PJN12906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN12906">
        <property type="protein sequence ID" value="PJN12906"/>
        <property type="gene ID" value="CG723_07825"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011613">
        <property type="entry name" value="GH15-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045582">
        <property type="entry name" value="Trehalase-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19291">
        <property type="entry name" value="DUF5911"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00723">
        <property type="entry name" value="Glyco_hydro_15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="SSF48208"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF5911" evidence="2">
        <location>
            <begin position="3"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_hydro_15" evidence="1">
        <location>
            <begin position="217"/>
            <end position="540"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF19291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN12906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="594" mass="66041" checksum="57AE72D06DF2E3CC" modified="2018-04-25" version="1">MHRPLEDYALIGDQQTAALISRAGSVDWLCLPRFDSAACFAALVGKEDNGHWQLGPKDGGDCTRRSYRPGTLILDSEWDTDEGSVRVTDLMPQRDKAPDLVRLVEGLRGRVTMRSTLRLRFDYGSIVPWVRRSDGHHVAVAGPDSMWLRSEPPVHTWGKDLTTHSEFTVEEGESVAFVLTWHPSHEPRPGLIDPFESLRRSQEEWEEWSAQCRYEGPHKDAVLRSLLTLKALTFEPTGGVVAAPTTSLPEELGGVRNWDYRYCWLRDSTLTLGALVSAGYLDEAEAWRDWLLRAVAGDPADLQIMYGLSGERRLPEIELPWLAGYSHSVPVRSGNDAAHQLQLDVYGEVIDSLALARQAGMPSEPHAWRLQLALVGFLSTAWRQPDQGIWEVRGPRRHFVHSKVMAWVAADRIVSALEDEPGLLGDLDAIRRLRDDIHRDVLARGYDPERNTFTQYYGSTALDASLLLIPRVGFLPPDDPRVVGTVKAVRDELSHDGFVRRYSAEASGLDGLPGREGTFLVCSFWLADALHLTGRTQEARELFDKLCGVGNDLGLLAEEYDPLSGRQLGNFPQAFSHIGLVGTALTLFGTGEAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-05-25" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K1E5</accession>
    <name>A0A2M9K1E5_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NfeD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CG723_08055</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CB01635</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000002">
        <property type="protein sequence ID" value="PJN12946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN12946">
        <property type="protein sequence ID" value="PJN12946"/>
        <property type="gene ID" value="CG723_08055"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002810">
        <property type="entry name" value="NfeD-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01957">
        <property type="entry name" value="NfeD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="46"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="domain" description="NfeD" evidence="3">
        <location>
            <begin position="55"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PJN12946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="143" mass="14618" checksum="A3A413D3AFAC8426" modified="2018-04-25" version="1">MADIDAWVWWLIGAAALGIPLVITAMPEFGMLSAGAVAGAVTAGLGGGMVMQVLVFAAVSVALIAVVRPIAARHSAQRPVLATGIEALKGKQAVVVERVDGSGGRIKLAGEIWSARSLDDSESYEPGRQVDVVDIEGATAIVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K1Y8</accession>
    <name>A0A2M9K1Y8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CG723_00610</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000001">
        <property type="protein sequence ID" value="PJN13138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN13138">
        <property type="protein sequence ID" value="PJN13138"/>
        <property type="gene ID" value="CG723_00610"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021443">
        <property type="entry name" value="DUF3093"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11292">
        <property type="entry name" value="DUF3093"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PJN13138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="148" mass="15671" checksum="F987F57708577CD7" modified="2018-04-25" version="1">MELSTAPFEERLTAPRSWWLVSLLLGVACALILLPFGTLPLLGGLVGGTAAAAVVTSSYGSVRIRVVADSLVAGDAKIPLSALGDAEILDAEGARAWRTHKADPRAFMLLRSYVPTALRVDVTDPQDPTPYLYLSTRDPKGLAKALGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-06-02" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K2L9</accession>
    <name>A0A2M9K2L9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_01970</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000001">
        <property type="protein sequence ID" value="PJN13369.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN13369">
        <property type="protein sequence ID" value="PJN13369"/>
        <property type="gene ID" value="CG723_01970"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="419"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="577"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="423"/>
            <end position="451"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN13369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="599" mass="65083" checksum="CF86CA131B9167C7" modified="2018-04-25" version="1">MDRSSQFAPFGTRAAALLGQWQQQNHRPLTAPAWLDTGGSGASLASVFVRDSDPGRTKRRMIIKLCSPDGDSSMEPGRLVAARRSLPNGDTSFPRDHLVEQLYDPMPVDDAWLMFQGFAGNDETMVTLSTILRQRRMPGVAAQITRSLLADWNPDEDSDGQMSAASFVSELLDRRLEPAEPLAVWVRDKLGLNLDTAWIRLGRPNAAPVPNPVHLTGNCPLAARTIDYPMRGRAHGDLHPGNIMVPREPDADMDRYVLIDLSRFDERALLARDPVHLLLCLVADFLPHLSDDARAELLDLLIGRDTPGLLIPQGLARTVDEVRKAPGGWLHQRTISGQWTGQWLLSMQACALMFTARVRYDARDRWWFFRLAAEAAGACLGPAEAYEPGEVKFVPGPREAEPKVVEVVVAAAAKVPKQVTPPEAKPGAEPGPVRVPAPAPVREPAPETPPEPLPGTLPALLLDLGNAFGTGLEELRQQEAGSVIAKTLGFIREQAYRGQIDLSALLDAAAGTLGEEDRSRLHEVRGHLASVTEAANEPGFSHKQPLFVRDLAHRALVMRIDQLLVSARDAALGLQAGRAGKTGQATDPIRTEGARAPSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K2R0</accession>
    <name>A0A2M9K2R0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Pyridoxamine 5'-phosphate oxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_01865</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000001">
        <property type="protein sequence ID" value="PJN13350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN13350">
        <property type="protein sequence ID" value="PJN13350"/>
        <property type="gene ID" value="CG723_01865"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024031">
        <property type="entry name" value="MSMEG_5819/OxyR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011576">
        <property type="entry name" value="Pyridox_Oxase_put"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01243">
        <property type="entry name" value="Putative_PNPOx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04023">
        <property type="entry name" value="PPOX_MSMEG_5819"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Putative_PNPOx" evidence="1">
        <location>
            <begin position="6"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN13350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="122" mass="13588" checksum="CE95BC342D72154F" modified="2018-04-25" version="1">MTEFSEAELTYLKSQRLGRLATVDPKGQPQANPVGFFPQDDGTILVGGYTLGKTKKWRNLQANPKVALVVDDILSVKPWKVRGVDVRGEAELLTGPHHLGAHFSEELIRIHPHKIHSWGLDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K395</accession>
    <name>A0A2M9K395_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Acyl-CoA dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CG723_03250</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CB01635</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000001">
        <property type="protein sequence ID" value="PJN13589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN13589">
        <property type="protein sequence ID" value="PJN13589"/>
        <property type="gene ID" value="CG723_03250"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003995">
        <property type="term" value="F:acyl-CoA dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006089">
        <property type="entry name" value="Acyl-CoA_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="SSF47203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="SSF56645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00072">
        <property type="entry name" value="ACYL_COA_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0274">FAD</keyword>
    <keyword evidence="3 5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA_dh_N" evidence="8">
        <location>
            <begin position="9"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_M" evidence="7">
        <location>
            <begin position="124"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_1" evidence="6">
        <location>
            <begin position="232"/>
            <end position="380"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PJN13589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="388" mass="42359" checksum="F41782D81208471D" modified="2018-04-25" version="1">MSTLDTLSSDELMIVETVRNFVDREVKPVVRELEHANTYPEALIEQMKDLGIFGLAIPEEYGGTPVSTPCYVLITEELARGWMSLAGAMGGHTVVSKLLLHFGTDEQKNRYLPKMATGEIRSTMALTEPGGGSDLQAMRTVARRDGDSYVVNGGKTWITNSRRSQLIALLCKTDPAAEPKHRGISILLAEHGPGLTVSRDLPKLGYKGVESCELTFDDYRVPAGALLGGIEGKGFGQMMKGLETGRLQVASRALGVGRAAFEDALRYAQERETFGEPIYKHQSIGNYLADMATSLTAARQLTLYAAREADAGRRVDMEAGMAKLFASETAMEIALNAVRIHGGYGYSTEFDVERYFRDAPLMIVGEGTNEIQRNVIVRQLVSRGGLDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K3G1</accession>
    <name>A0A2M9K3G1_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">UDP-glucose 4-epimerase</fullName>
            <ecNumber evidence="5">5.1.3.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">galE</name>
        <name evidence="9" type="ORF">CG723_03710</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CB01635</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>UDP-alpha-D-glucose = UDP-alpha-D-galactose</text>
            <dbReference type="Rhea" id="RHEA:22168"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="ChEBI" id="CHEBI:66914"/>
            <dbReference type="EC" id="5.1.3.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Carbohydrate metabolism; galactose metabolism.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the NAD(P)-dependent epimerase/dehydratase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.1.3.2" evidence="5"/>
    <dbReference type="EMBL" id="NNBL01000001">
        <property type="protein sequence ID" value="PJN13663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN13663">
        <property type="protein sequence ID" value="PJN13663"/>
        <property type="gene ID" value="CG723_03710"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00214"/>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003978">
        <property type="term" value="F:UDP-glucose 4-epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006012">
        <property type="term" value="P:galactose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005886">
        <property type="entry name" value="UDP_G4E"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01179">
        <property type="entry name" value="galE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0520">NAD</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Epimerase" evidence="8">
        <location>
            <begin position="3"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00018569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PJN13663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="327" mass="34401" checksum="B2BD76E292B93EE4" modified="2018-04-25" version="1">MTWLITGGAGYIGAHVARAMAAAGEDVVVLDDVSTGVSERLPSDIELVRGSALDPELVKRVCAEHSVTGVVHLAARKQVGESVERPELYYRDNVGGLAVLLDAVAEAGVRRFVFSSSAAVYGNPDVDLITESTPCAPMSPYGETKLAGEWLVRAAGRAHGMATVCLRYFNVAGAAAPELADTGIFNVIPMIFDRLSRGEAPRIFGDDYGTPDGTCVRDYLHVADLAEAHLAAARRLTAPGATGDLTVNIGSGEGVSVRELVGLISEVSGDPRAAVVEPRRAGDSPRAVASAELAAKELGWVASRGVREMVESAWAGWRLRHPESTAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K3G7</accession>
    <name>A0A2M9K3G7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Cation transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CG723_03705</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CB01635</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000001">
        <property type="protein sequence ID" value="PJN13662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN13662">
        <property type="protein sequence ID" value="PJN13662"/>
        <property type="gene ID" value="CG723_03705"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008324">
        <property type="term" value="F:cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1510.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002524">
        <property type="entry name" value="Cation_efflux"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036837">
        <property type="entry name" value="Cation_efflux_CTD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027469">
        <property type="entry name" value="Cation_efflux_TMD_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01545">
        <property type="entry name" value="Cation_efflux"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160240">
        <property type="entry name" value="SSF160240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161111">
        <property type="entry name" value="SSF161111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01297">
        <property type="entry name" value="CDF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="27"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="58"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="87"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="129"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="159"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PJN13662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="310" mass="32402" checksum="66747BD84C761F01" modified="2018-04-25" version="1">MGAGHDHGHSHAPTGTVSAAHLGRLRIALGITLTVMVVEIVGGLLADSLALVADAAHMATDALGLGMALLAIHFANRPASEQRTFGFARAEILAALANCLLLLGVGGYVLVEAIQRFLEPAETEGGLTIVFGVIGLVANMISLSILVRGQKESLNVRGAFLEVAADALGSVAVIISATIILATGWQAADPIASIAIGLMIVPRTVKLLRETLNVLLEAAPKGVDMAEVRAHITELPGVLDIHDLHAWTITSGMPVLSAHVVVSSEALNAIGHEKMLHELQGCLGVHFDVEHCTFQLEPVGHAEHEAKLCH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-09-29" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K3Q7</accession>
    <name>A0A2M9K3Q7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Integrase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_04020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000001">
        <property type="protein sequence ID" value="PJN13710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN13710">
        <property type="protein sequence ID" value="PJN13710"/>
        <property type="gene ID" value="CG723_04020"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13683">
        <property type="entry name" value="rve_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="1">
        <location>
            <begin position="161"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN13710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="361" mass="41067" checksum="C601E5CB2588843F" modified="2018-04-25" version="1">MIGSLVYRVVRKLLAVPAVLLRRDMAKDAELLVLRHENAVLRRQLTGPVRYEPADRLWFAALSSLIPRRLWAQVFPVTPATLLAWHRRLIARKWDYSKRRSRHGRPATASAVKALVLQFAKQYPRWGCRRIQGELVRLGHPVGSTTVWEILTAAGIDPAPRRSGPTWREFLTAQTEGIIACDFLHIDLVDLRRVYALVFLEHGARRLHIAGVTAHPTGSWTVQQARNLAVELGVRVDSLRFLLRDRDAKYTESFDAVFAADDIRVVRTAPRAPRMNAHCERIIGTLRREALDHLLIWNETHARQVLDAYARHYNGHRPHQARGQLPPLAQEHPSPLIAPSAHGLLRTRILGGVINEYRHVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-05-25" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K3T5</accession>
    <name>A0A2M9K3T5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NADPH:quinone reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_03030</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000001">
        <property type="protein sequence ID" value="PJN13785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN13785">
        <property type="protein sequence ID" value="PJN13785"/>
        <property type="gene ID" value="CG723_03030"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="PKS_ER"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PKS_ER" evidence="1">
        <location>
            <begin position="10"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN13785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="307" mass="31875" checksum="DD81640F47D2342D" modified="2018-04-25" version="1">MRRVRYEHSGGPGVLFLEEAPVPEPGPGELLVRTEAIGVTLPVVRKVREPREPIPLGGEVAGAVAAVGTGVTEYAVGDRVTGLAFGHGYADHALLHVAMASPVPDGASATDAVALVRSGLVAYGALQAARPEPGEAALVTAAASGVGHLALQLASSSGATRVIAAVSDPGKAEFVRGLGADDVVTYDDENWGEPVDYVLDAVGGELLTPGLRALAPHGRLVAYSSGGGTVEAYDLLVGAKSVIGFQMALIARGKPETYERWRTELWRLFFEGALRPMVHAEFALEDAARAHEAIEGRANLGKVVLIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K3V1</accession>
    <name>A0A2M9K3V1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CG723_01530</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CB01635</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000001">
        <property type="protein sequence ID" value="PJN13750.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN13750">
        <property type="protein sequence ID" value="PJN13750"/>
        <property type="gene ID" value="CG723_01530"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="27"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="90"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="123"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="166"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="230"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="278"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="86"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PJN13750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="310" mass="33281" checksum="60464CC6B5BB32DE" modified="2018-04-25" version="1">MATATTRTGKRAPGPPGGGRPADRGAAWFLVLPALIPILVLSVGPLLYGIALAFTDSQAGRTAPTQWVGALNFQDLLHDTLFWDSFRIGLLWAVGVTVPQFLLALGLALLLNQNLRFRWLARALAIIPWAMPEVVVGIMWRLVYNPDAGILNETIRDLGLGDGRDWLTGLATALPAVIVVGIWAGMPQTTVALLAGLQNTSPELHEAAALDGAGAWGRFRAVTWPALRPVALAITALNFIWNFNSFALVYVLTNGGPGGRTRLPMLFAYEEAFRYGQFGYAAAMGCVMVAVISVILAFYLVGRLKGGDEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JES7</accession>
    <name>A0A2M9JES7_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Lysine--tRNA ligase</fullName>
            <ecNumber evidence="9">6.1.1.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Lysyl-tRNA synthetase</fullName>
            <shortName evidence="9">LysRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">lysS</name>
        <name evidence="11" type="ORF">CG723_45145</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CB01635</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>ATP + L-lysine + tRNA(Lys) = AMP + diphosphate + L-lysyl-tRNA(Lys)</text>
            <dbReference type="Rhea" id="RHEA:20792"/>
            <dbReference type="Rhea" id="RHEA-COMP:9696"/>
            <dbReference type="Rhea" id="RHEA-COMP:9697"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:32551"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78529"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.6"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.6" evidence="9"/>
    <dbReference type="EMBL" id="NNBL01000050">
        <property type="protein sequence ID" value="PJN05400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN05400">
        <property type="protein sequence ID" value="PJN05400"/>
        <property type="gene ID" value="CG723_45145"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004824">
        <property type="term" value="F:lysine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006430">
        <property type="term" value="P:lysyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.350">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00177">
        <property type="entry name" value="Lys_tRNA_synth_class1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020751">
        <property type="entry name" value="aa-tRNA-synth_I_codon-bd_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008925">
        <property type="entry name" value="aa_tRNA-synth_I_cd-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002904">
        <property type="entry name" value="Lys-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042078">
        <property type="entry name" value="Lys-tRNA-ligase_SC_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37940">
        <property type="entry name" value="PTHR37940"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01921">
        <property type="entry name" value="tRNA-synt_1f"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48163">
        <property type="entry name" value="SSF48163"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00467">
        <property type="entry name" value="lysS_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 9 11" id="KW-0436">Ligase</keyword>
    <keyword evidence="5 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 9" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="177"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'HIGH' region" evidence="9">
        <location>
            <begin position="42"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'KMSKS' region" evidence="9">
        <location>
            <begin position="326"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="177"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PJN05400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="581" mass="63594" checksum="865D7EC61186576C" modified="2018-04-25" version="1">MPIVAQSTETTDWVSRYADEVIAESERRAPGKPVVVASGLSPSGPIHLGNLREVMTPHLVADEVRRRGYEVRHLISWDDFDRYRKVPAGVPGVDESWADHIGKPLTSVPAPAGSAFPNWAEHFKAAMTGALADLGVEFDGISQTEQYTSGVYREQILHAMKHRGDIDAILDQYRTKKVPPKQQKQQKPVDEAELEAAEGSGAANEDDGSGGAGGYYPYKPFCGECGKDLTTVTSYDDETTELSYTCTLDGHSETVRLSEFNRGKLVWKVDWPMRWAFEGVIFEPSGVDHSSPGSSFQVGGQIVGIFGGKQPIGPMYAFVGISGMAKMSSSKGGVPTPADALQIMEPQLLRWLYARRRPNQSFKIAFDQEIQRLYDEWDKLASKVADGPVLPADAAAYTRAVGTAAGELPRTPRPLPYRTLASVADITAGAEDQTLRILSELDPENPVTALDEVRPRLDRAETWISKYVPAESRTLVREEPDTQALAALDDEARESLRLLLDGLDSHWSLDGLTHLVYGVPKVRAGFSPDATPKELPPEIKSAQRSFFALLYDLLVGRDTGPRLPTLLLAVGADRVRKLLGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JF08</accession>
    <name>A0A2M9JF08_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Electron transfer flavoprotein subunit beta</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CG723_44380</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CB01635</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">The electron transfer flavoprotein serves as a specific electron acceptor for other dehydrogenases. It transfers the electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase (ETF dehydrogenase).</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Heterodimer of an alpha and a beta subunit.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000047">
        <property type="protein sequence ID" value="PJN05485.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN05485">
        <property type="protein sequence ID" value="PJN05485"/>
        <property type="gene ID" value="CG723_44380"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01714">
        <property type="entry name" value="ETF_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014730">
        <property type="entry name" value="ETF_a/b_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012255">
        <property type="entry name" value="ETF_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033948">
        <property type="entry name" value="ETF_beta_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21294">
        <property type="entry name" value="PTHR21294"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01012">
        <property type="entry name" value="ETF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000090">
        <property type="entry name" value="Beta-ETF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00893">
        <property type="entry name" value="ETF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ETF" evidence="3">
        <location>
            <begin position="24"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00025649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PJN05485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="261" mass="27442" checksum="AEE205DDE9315942" modified="2018-04-25" version="1">MSLRIVVAVKYVPDATGDRRFDQDLTTDRDAVDGLLSELDEYAVEQALQIAETADDAEVTVLTMGPEEAQEALRKALSMGADKAVHIEDEGVHGTDIMGTSLVLAKAIKHLGYDLVVCGMASTDGTAGVVPALLAERLSVPQVTFLSEVALADGKVTGRRDGDAASEWVEATLPALVSVTDQSGEARYPSFKGIMAAKKKPMESLDLSDLGIDEAEVGLLGAWTAVSEATARPARVAGTVTKDEGEGGKQIAAFLAEQKLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JF63</accession>
    <name>A0A2M9JF63_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_45045</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000050">
        <property type="protein sequence ID" value="PJN05397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN05397">
        <property type="protein sequence ID" value="PJN05397"/>
        <property type="gene ID" value="CG723_45045"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="54"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="87"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="145"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="171"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN05397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="216" mass="23010" checksum="DED988ECFB3B4888" modified="2018-04-25" version="1">MGSLRPLVVDVVVPMASYYVLSKGFGMSTLAALGWSSVLPALRTVWGVLRERRLNVLAGVILVVNMVGLLLSTVTGDPRLMLAKDSGISSAVGISMLVSVVAGKPLLTSALRPFVTKGDAERTGAWERLSAGPGRFVRAERMFTAVWGLALVTECVVRIVGAYTLPVGTMVWLGNVIMAGAVVLAFRVSGRLAVGPMERMVEEELVSRRGEVERVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-06-02" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JFY7</accession>
    <name>A0A2M9JFY7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_42810</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000041">
        <property type="protein sequence ID" value="PJN05801.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN05801">
        <property type="protein sequence ID" value="PJN05801"/>
        <property type="gene ID" value="CG723_42810"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="72"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="72"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN05801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="123" mass="13521" checksum="B7AD9865F9AB7696" modified="2018-04-25" version="1">MHAYDLPRRPQYPTPIPAMRGTHESAGGRSATPIYDALYAEYRRSFRALPGDRSGEENLSFSAFGSSLYAVHHSTSGRHSASYHEPQHVHSSPPTGSWNTNGRQHSTGSNLPAALPPGPRRER</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-09-29" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JGF9</accession>
    <name>A0A2M9JGF9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Aldehyde dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_41705</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000037">
        <property type="protein sequence ID" value="PJN05965.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN05965">
        <property type="protein sequence ID" value="PJN05965"/>
        <property type="gene ID" value="CG723_41705"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016620">
        <property type="term" value="F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="SSF53720"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldedh" evidence="2">
        <location>
            <begin position="17"/>
            <end position="476"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN05965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="482" mass="50271" checksum="B0D229E9081C10B9" modified="2018-04-25" version="1">MTYQREAPTGLPVGDTWVPAPSQQPVVFPYDGSEFASAPVGDVDVARRAVEHAAGRRKEVAALSARVRRDVLAGVAADLEGVASRMAELLVLETGKPRVDCDIEMQRAAATWRAAADEVAHLHGETVPLDLQASGDGMFGFWMRRPIGVVVGIAGFNYPVLLASHKIAPALAAGCPVIVKPAPATPLATLWLTHLVRERLAAAGAPPGAVQLVTGDTEVGRTLTTHPDVAAVSFTGSATVGHRIARDAAPRKVVLELGSNAALVVAADADLDAAADAVARGGYYASGQACISVQRVIAVEEIAGALEKKIAERLPDVVVGDPRDAGTRVSALIDEAATERVLDWIGRARAAGARVVAGGVRTGTRCLAPTLLADVPDGEPAWDEEVFGPVVCLRAVPDLDAAYDLVNASRYGLHAAVYTRDLGAAFRAVDALDVGGVVINEVPGYRSDIAPYGGVKDSGTGREGPRFAIEELTVTRMAVIRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JGI3</accession>
    <name>A0A2M9JGI3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Peptide ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CG723_41820</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CB01635</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000037">
        <property type="protein sequence ID" value="PJN05988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN05988">
        <property type="protein sequence ID" value="PJN05988"/>
        <property type="gene ID" value="CG723_41820"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025966">
        <property type="entry name" value="OppC_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12911">
        <property type="entry name" value="OppC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="36"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="104"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="140"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="163"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="265"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="98"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PJN05988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="301" mass="31884" checksum="285D1B526D756800" modified="2018-04-25" version="1">MSTSAVLPVQPGQEEAAQATPSLARRTLRVFTGNKLALTGVVVLVLLLAFCYLGPLVHPTEQIHTDLAQANLSPGTAGHLLGTTDLGYDLLGRLMVAGRTSLEIGLAAGLLATLFGTVYGAVAGYFGGWVDAAMMRVTDAALAIPAMFLLVVVAAIITPSKGVLILIIAGVAWLSPARLVRGEALSLRNREYVQAMRMMGGGGMRAVFRHIVPNTIGTVIVNCTFQIADAILYVSYLAFLGLSIPPPSADWGSMLSAGITYTQNGYWWLIFPPGIAIVLVVAAFNFIGDGLRDAFEVRLRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-09-29" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JGR9</accession>
    <name>A0A2M9JGR9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">1-acyl-sn-glycerol-3-phosphate acyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_41615</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000037">
        <property type="protein sequence ID" value="PJN05947.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN05947">
        <property type="protein sequence ID" value="PJN05947"/>
        <property type="gene ID" value="CG723_41615"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002123">
        <property type="entry name" value="Plipid/glycerol_acylTrfase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01553">
        <property type="entry name" value="Acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00563">
        <property type="entry name" value="PlsC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PlsC" evidence="1">
        <location>
            <begin position="38"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN05947.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="242" mass="26780" checksum="A731CD3A0FCC458B" modified="2018-04-25" version="1">MAELVYRPVIGAARTMFKALDLKIDVKGAENIPRSGGAVLVSNHISYLDFIFDGLAALPQKRLVRFMAKESVFRHKISGPLMRSMKHIPVDRKQGEDAYAHALDSLRSGQVIGVFPEATISQSFTLKSFKSGAARLAQEAGVPLIPMALWGTQRLWTKGHPKNFKRHHIPITIRVGEPMEAPRDQYAGAITRRLRERVQELLEAAQRAYPVRPKGPDDTWWMPAHLGGTAPTAAEVKAAEAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JGT4</accession>
    <name>A0A2M9JGT4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CG723_41435</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000036">
        <property type="protein sequence ID" value="PJN06063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN06063">
        <property type="protein sequence ID" value="PJN06063"/>
        <property type="gene ID" value="CG723_41435"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022385">
        <property type="entry name" value="Rhs_assc_core"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03696">
        <property type="entry name" value="Rhs_assc_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PJN06063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="199" mass="22564" checksum="145C7C7A764DD1A9" modified="2018-04-25" version="1">MNRHYDPETARYVSADPLGLVPAPNPAAYVVNPFTFMDPEGLVAKGCTQESGWYGGLLPANTKKDGSKYPQPMEVNHIPAKSAYKDVIEPGFYIANKPHKKQKVNNGPAIRMQRDHHEQLYSTGYSLQSQAWQQYQRELINSGRITDAMRMDIDDIKRRFPGTYDQHIKDMVASLDDNKPLQDMLKTRGWKIDKAALLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JH37</accession>
    <name>A0A2M9JH37_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_40740</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000034">
        <property type="protein sequence ID" value="PJN06196.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN06196">
        <property type="protein sequence ID" value="PJN06196"/>
        <property type="gene ID" value="CG723_40740"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="62"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="77"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN06196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="209" mass="22390" checksum="5656E98E32C6D09B" modified="2018-04-25" version="1">MTDNPVTVTSVTSQYATQVAQDLDLNAKEQERISAEHSALQAQLRILQDDQNVLHSIQKTLGNRPASAPTTPKPSTPLPQQASGKTTTRRAPSKNAAKAPRTKKTTVQAKKDKTQGAESKAATSSAQPTLIALIRTHLDQQKEPRSAAEVASTLAEAHPRRTIKPTVVRTTLENLVAKSQAHRSKQGASVLYTSVTVQAPTEKAPAPVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JH46</accession>
    <name>A0A2M9JH46_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DNA-binding response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CG723_40490</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000034">
        <property type="protein sequence ID" value="PJN06204.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN06204">
        <property type="protein sequence ID" value="PJN06204"/>
        <property type="gene ID" value="CG723_40490"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00622">
        <property type="entry name" value="HTH_LUXR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="2"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="domain" description="HTH luxR-type" evidence="3">
        <location>
            <begin position="151"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PJN06204.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="221" mass="24039" checksum="0A33A522C0F7E196" modified="2018-04-25" version="1">MRIVLADDSVLIRAGIREILTSNAHDVIRECEDADELIAAVDELARAGVTPDVVITDVRMPPKNTDDGLRAAIDLRSRHRNLPMLVLSAYVTGPYVRELLNGPGADGAVGYLLKEKVGRVADFLRAIETVSGGGVVIDPEVVRHVTRADSPQGPLARLTAREQEVLALMAEGRSNAEIATELFLSGASVSKHVANVFVKLGMPPDEDNRRVKAILTWFEYH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-06-02" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JHS3</accession>
    <name>A0A2M9JHS3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_39115</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000030">
        <property type="protein sequence ID" value="PJN06424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN06424">
        <property type="protein sequence ID" value="PJN06424"/>
        <property type="gene ID" value="CG723_39115"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="66"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="98"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN06424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="146" mass="15663" checksum="AB9BE269C4CFCD65" modified="2018-04-25" version="1">MEHVPRGVVPLVSPAPERRRLHPGRLRVPDRAAPADVMYVLRTGLAWRDVPAERVGCSGSDGLAPAAGLDRSRRPALPPTVSTCGSVSKRPARRAACPSRTGSTTARSGRRSGSRRTPYQSAWSGGAAKGITNSQCWFTPECLLHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-05-25" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JHW4</accession>
    <name>A0A2M9JHW4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_39475</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000031">
        <property type="protein sequence ID" value="PJN06347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN06347">
        <property type="protein sequence ID" value="PJN06347"/>
        <property type="gene ID" value="CG723_39475"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046151">
        <property type="entry name" value="DUF6153"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19650">
        <property type="entry name" value="DUF6153"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014644120" evidence="2">
        <location>
            <begin position="35"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="44"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="114"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN06347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="143" mass="13962" checksum="2985FB4474F40CA0" modified="2018-04-25" version="1">MRPQLTLRLLGLLVGAVLLGLLGMHGLGPVPAGAHGEMHPAAAPATGGAADAVDHAGPERQGVKASAPDMCDHGEGGCEGHMAHADSVCASASVAGPPAVAPALLPDVIACPARPEARTSSAGSGPDGGRAPPSLSELQLLRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JI18</accession>
    <name>A0A2M9JI18_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">N-acetylmuramoyl-L-alanine amidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_38740</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000029">
        <property type="protein sequence ID" value="PJN06529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN06529">
        <property type="protein sequence ID" value="PJN06529"/>
        <property type="gene ID" value="CG723_38740"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008745">
        <property type="term" value="F:N-acetylmuramoyl-L-alanine amidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009253">
        <property type="term" value="P:peptidoglycan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06583">
        <property type="entry name" value="PGRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.80.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036505">
        <property type="entry name" value="Amidase/PGRP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002502">
        <property type="entry name" value="Amidase_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01510">
        <property type="entry name" value="Amidase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00644">
        <property type="entry name" value="Ami_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55846">
        <property type="entry name" value="SSF55846"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetylmuramoyl-L-alanine amidase" evidence="1">
        <location>
            <begin position="54"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00644"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN06529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="207" mass="23044" checksum="0F426DB3B2EB6AE8" modified="2018-04-25" version="1">MLIGGAATAVGVGLLARSDLAHMWWQMPGIDKPRKAGEVDFRGAEWVAAAAANWRRADRPADYTIDRVIIHVTQGSYQGTLKVFKDPWHGAAAHYVVRKDGHIAQMIRELDVAFHAGNKEFNERSVGIEHEGFVDRPADFTDAMYASSARLTAGICRRYGIPVDRQHIIGHVEVPGTDHTDPGPHWDWDRYMGLVKRAHEEGRTAKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JIQ1</accession>
    <name>A0A2M9JIQ1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_37340</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000026">
        <property type="protein sequence ID" value="PJN06748.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN06748">
        <property type="protein sequence ID" value="PJN06748"/>
        <property type="gene ID" value="CG723_37340"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01381">
        <property type="entry name" value="HTH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="17"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN06748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="187" mass="19691" checksum="315C7914BDE9BE61" modified="2018-04-25" version="1">MAGQTPRLPLDRIAAALRRERGRAGISLSELAKRAGIAKSTLSQLESASGNPSLETLWALSVALDVPPSLLLDAPRPVVQVIRAGEGVAVPSEQADYAATLLSPNPPGSRRDLYFLQVEPGAPRDSEPHMPGAVEHIVVGTGRVLAGPQDDPVELGPGDYMSYPGDVPHTCRALEPGTTCVLVMQYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JIW8</accession>
    <name>A0A2M9JIW8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CG723_36700</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CB01635</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000025">
        <property type="protein sequence ID" value="PJN06826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN06826">
        <property type="protein sequence ID" value="PJN06826"/>
        <property type="gene ID" value="CG723_36700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003838">
        <property type="entry name" value="ABC3_permease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025857">
        <property type="entry name" value="MacB_PCD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02687">
        <property type="entry name" value="FtsX"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12704">
        <property type="entry name" value="MacB_PCD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014773738" evidence="8">
        <location>
            <begin position="43"/>
            <end position="856"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="269"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="318"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="364"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="407"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="442"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="496"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="729"/>
            <end position="754"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="779"/>
            <end position="799"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="819"/>
            <end position="842"/>
        </location>
    </feature>
    <feature type="domain" description="MacB_PCD" evidence="10">
        <location>
            <begin position="22"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="domain" description="FtsX" evidence="9">
        <location>
            <begin position="299"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="domain" description="MacB_PCD" evidence="10">
        <location>
            <begin position="501"/>
            <end position="697"/>
        </location>
    </feature>
    <feature type="domain" description="FtsX" evidence="9">
        <location>
            <begin position="758"/>
            <end position="848"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="60"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="76"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF12704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PJN06826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="856" mass="89613" checksum="751CC11B1F23037B" modified="2018-04-25" version="1">MSANTVMKTSLRNFFAHKGRMALSAVAVLLSVAFVCGTLVFTDTMNTTFDKLFAATSSDVTVSPKAARSEGSDTGRPESMPASTLTQVKRADGVKSAEGAVSSMNVTVVDADNKNMGSENGGPTIAGNWTHNDLRSMDITSGHAPRGPTEVMVDSDTADKHHLKMGDELRTIAATGDFRAKIVGIASFKVTNPGAAVVYFDTATAQRELIGRSDRFTQINVAAAPGVSDTVLKKNVAASLDGPYKFQTQKETADANRKDVGSFMNVIKYAMLGFAGIAFLVGIFLIINTFSMLVAQRTREIGLMRAIGSSRKQANRSVLVEALLLGVFGSVIGVGAGVGLAVGLMKMMSAAGMDLSTDDLTVKWTTPVVGLLLGIVVTVFAAYIPARRAGKVSPMAALRDAGTPADVKAGVVRALIGLVLTGGGGFALYTATQAAKASEGSLWLGVGIVATLIGFVVIGPLLAGGVVRVISAVLLRMFGSVGRMAERNALRNPRRTGATGAALMIGLALVACLSVVGSSMVASATSELDKSVGADFIVEGQNGLKPQAAEALKKAPYVSHVTEVKYVKTKLTTPGGTKEDEELVAATPTYAQDLRRETTAGELSAAYGKNAMSVGSEFATKNHLKVGDTMNVAFERGRTADLKIAAITSDDTTFDKGAMYIGLATAKQYVPAGQLPLNGMMFAKADSGKADQAYKALKASVASDPTVHVKDQTDYKQTLKDQIGQLLNMIYGLLALAIIVAVLGVVNTLALSVVERTREIGLMRAIGLSRRQLRRMIRLESVVIALFGALIGLGLGMGWGATAQKLLALEGLNVLEIPWPTIIGVFIGSAFVGLFAALVPAFRAGRMNVLNAIATE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JJC7</accession>
    <name>A0A2M9JJC7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ectoine/hydroxyectoine ABC transporter ATP-binding protein EhuA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CG723_36500</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000024">
        <property type="protein sequence ID" value="PJN06985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN06985">
        <property type="protein sequence ID" value="PJN06985"/>
        <property type="gene ID" value="CG723_36500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015424">
        <property type="term" value="F:ABC-type amino acid transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030679">
        <property type="entry name" value="ABC_ATPase_HisP-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039085">
        <property type="entry name" value="ABC_ATPase_HisP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="12"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="44"/>
            <end position="51"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PJN06985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="260" mass="28611" checksum="66A1AD910B0F5200" modified="2018-04-25" version="1">MSVTTTNERALVRAESVHKSYGDLQVLRGIDLEVHQGEVVCLLGPSGSGKSTFLRCINHLEQVNSGRIWVGDEAIGYRQQGNKLHGLNERAIARQRRRIGMVFQRFNLFPHMTALENVMAAPVGVKRVAREAARERAVALLGKVGLKDKSDAYPRQLSGGQQQRVAIARALAMQPDLMLFDEPTSALDPELVGEVLDVMKDLARSGLTMMVVTHEIAFAREVADRVAFMDGGKVLEIGPPSEILGNPQHPRTQSFLARVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JJH9</accession>
    <name>A0A2M9JJH9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Pyruvate carboxyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CG723_36150</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CB01635</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HMG-CoA lyase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000024">
        <property type="protein sequence ID" value="PJN06937.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN06937">
        <property type="protein sequence ID" value="PJN06937"/>
        <property type="gene ID" value="CG723_36150"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016833">
        <property type="term" value="F:oxo-acid-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043594">
        <property type="entry name" value="HMGL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000891">
        <property type="entry name" value="PYR_CT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42738">
        <property type="entry name" value="PTHR42738"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00682">
        <property type="entry name" value="HMGL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50991">
        <property type="entry name" value="PYR_CT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pyruvate carboxyltransferase" evidence="3">
        <location>
            <begin position="7"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PJN06937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="311" mass="32775" checksum="B14369F54A20E3D9" modified="2018-04-25" version="1">MSLPDAVRIREIAPRLTFQDHVVPTEVKIELVRRLIDAGVRAFELSSFVRPDLVPGLADAEEVFARVPRVPGLSLGCCVGNTRGLTHAVGAGADTAYFLLSADEEFARANTGRSTPESLRELERMAAFAADHDVVLGTYIIFAWGGPTGAARSGEDLEPLARRLLDIGVDHWILADSSGYAAPPQIRELVTAALAHVPPGNLTVQIHDDRGMGLAALLPLLQLGIHAIDTSLAGSGGHPAMPGTRGGGLCTEDAVQLLQLCGVDTGIDLPRLIETANWLTSEIGVPGKGFVRHAGCVPGSAEPGKPLAFAW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JJI6</accession>
    <name>A0A2M9JJI6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CG723_35460</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000023">
        <property type="protein sequence ID" value="PJN07036.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN07036">
        <property type="protein sequence ID" value="PJN07036"/>
        <property type="gene ID" value="CG723_35460"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="SSF48371"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PJN07036.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="539" mass="56258" checksum="626FCE7271FBA992" modified="2018-04-25" version="1">MTPDLVLCGLAANTALPKDLIDQLTDQLTTAARNTPAGGTPRAHVSGPAGALAGDSLSDLVNELADRPDLTHAQAAALASLDEYAAVRLAYAGLLTADDIDPAARPLAALALLDEGAGRETWVRAFATDPVVMHREKLAACPDLPSDVTEALASDPDIRVVAELASWTTPAMAIRLARHPHAEVRRAVAANERTPPAVLSALITEGVLPPAQACVVCESKTTPFVHDPQCPIPDCTLPPDASCDGVTHASTVHAMQCLALQNPATPAEAAAAFANHSSAVLRWALASRPGLPPETYARLAQDPVPGIRADLAANPSIGEPLMRELATDPGHDVQRRLAHNAAVPLDILISLAGTTKTGSVLLPRIAAASLAEVEELAASPYPAVRMLLAARRDLPNGIRDALAADPDAKVLKAVAPHPGLSEAQLRAMVDRHGARVIARVATNPSATPSLLAYLAHQVEHRSPAQKLLREIARHRNATAPALLACLSDVRARPLAAAHRALPPAVIAELLVDDDPHVAAAAATNPSLPPELMWTLFAGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JJV1</accession>
    <name>A0A2M9JJV1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">TetR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_34710</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000022">
        <property type="protein sequence ID" value="PJN07150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN07150">
        <property type="protein sequence ID" value="PJN07150"/>
        <property type="gene ID" value="CG723_34710"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023772">
        <property type="entry name" value="DNA-bd_HTH_TetR-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045823">
        <property type="entry name" value="TetR_C_32"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19344">
        <property type="entry name" value="TetR_C_32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01081">
        <property type="entry name" value="HTH_TETR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="14"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="36"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN07150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="218" mass="23830" checksum="FF2A595B39AC77E3" modified="2018-04-25" version="1">METTQRTEQQTSAERRRRELLEAADRVVLRDGPGASMNAIAAEAGITKPILYRHFGDKGGLYAALAKRHTDALLASLRAALDAPAERRERVESTLDTYLAAIEARPQVYRFLMHPSESVSESAAPGEQGFYVGMHSAPLLRRMGEELAEVIEERIDLGPGSQQLARVWGHGIVGMMHAAGDWWLGERPCSRSELVRSLADLLWGRLAAAGDKVGGPGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JJZ7</accession>
    <name>A0A2M9JJZ7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CG723_35865</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CB01635</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000023">
        <property type="protein sequence ID" value="PJN07107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN07107">
        <property type="protein sequence ID" value="PJN07107"/>
        <property type="gene ID" value="CG723_35865"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004638">
        <property type="entry name" value="EmrB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00711">
        <property type="entry name" value="efflux_EmrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="30"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="96"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="121"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="154"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="184"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="217"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="242"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="286"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="320"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="350"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="379"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="411"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="487"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="7">
        <location>
            <begin position="31"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="514"/>
            <end position="584"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PJN07107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="584" mass="60055" checksum="FD2584D4988406A7" modified="2018-04-25" version="1">MAETGTVAAVDTGGGGEAATKERQPRSVRVVLMALMIAMLLAMLDNMIVGTAMPTIVGDLGGLEHLSWVVTAYTLATAASTPIWGKVGDMYGRKGAFLTSIVIFLIGSGLSGMAQDMNQLIAFRAIQGLGAGGLMVGVMAIIGDLIPPRERGKYQGMMAGVMALAMIGGPLVGGAITDNWGWRWSFYINLPLGLVALAMVTAVLHLPKKRSKGKIDYLGAALLTVGITSIVLVTTWGGSQYAWGSAVIMELAAIGVAALVGFLFVQTKAAEPIMPLHIFRSRNFTVMSLIGFITGFVMFGAVLFLPLYQQTVQGANATNSGLLLLPMLLSMMVVSLVAGRVTTNTGKYKVFPLVGSVLMVAGLFLLAQMDTETTRLTSGLYMAVLGAGMGCLMQITMLVAQNSVEMKDMGVASSSTTLFRTLGSSFGVAIMGALFNNRVQDVMAERAGATGGKVAEHSTQLTAEGLAKLPDVVRDAYLHAVSAGTHSAFLLGSVIAVLALIAAVFVKEVPLRGAGPAKEAPSSPEAAGPADAQPIDMAKAGTATAAAAANGTAETGTATADAKPVEGGAAGDAAADGRTVSETV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JK73</accession>
    <name>A0A2M9JK73_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DUF885 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CG723_34995</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000022">
        <property type="protein sequence ID" value="PJN07279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN07279">
        <property type="protein sequence ID" value="PJN07279"/>
        <property type="gene ID" value="CG723_34995"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010281">
        <property type="entry name" value="DUF885"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33361">
        <property type="entry name" value="PTHR33361"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05960">
        <property type="entry name" value="DUF885"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PJN07279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="567" mass="62125" checksum="BF93CD9E1009A1C6" modified="2018-04-25" version="1">MSDSSATAAAVTGPLPREVADTYVDELIALDPVTGTYLGVPESHSKLPDLSPAGQEALADLARATLARLDEAERRPGADSAAERRCGRLLRERLTAEIAVHDAEENLRAVTNLGGPVHNMREVFTLTPTATDADWAAVAERLRAVPGALAGYRETLSLGLEKKLHGGPRPTATFIGQLTEWAGEGRGWFEDFTADGPDALRAELDEAGSAATAAVVELRDWMRDVYAPAIEGSPDTVGRERYARWSRYYNGTDLDLDEAYAYGWAEYHRLLGEMRTEAEKILPGAATPWVALAHLDEHGTHIEGVEEVQRWLQGVMDEAIEALDGTHFELAERVRKVESMIAPAGSAAAPYYTAPSEDFSRPGRTWLPTMGQTRFPVYDLVSTWYHEGVPGHHLQIAQWTHVADSLSRYQASVGMVSANAEGWALYAERLMDELGFLTDAERRLGYLDAQMMRATRVIVDIGMHLELEIPADSPFHPGERWTPALAQEFFGAHSSRPADFVESELTRYLSIPGQAIGYKLGERAWLLGRAGAQARHGDAFDAKAWHMAALSQGSLGLDDLVDELSQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-09-29" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JKA8</accession>
    <name>A0A2M9JKA8_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Orotidine 5'-phosphate decarboxylase</fullName>
            <ecNumber evidence="7">4.1.1.23</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">OMP decarboxylase</fullName>
            <shortName evidence="7">OMPDCase</shortName>
            <shortName evidence="7">OMPdecase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7 9" type="primary">pyrF</name>
        <name evidence="9" type="ORF">CG723_34185</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CB01635</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>H(+) + orotidine 5'-phosphate = CO2 + UMP</text>
            <dbReference type="Rhea" id="RHEA:11596"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57538"/>
            <dbReference type="ChEBI" id="CHEBI:57865"/>
            <dbReference type="EC" id="4.1.1.23"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 7">Pyrimidine metabolism; UMP biosynthesis via de novo pathway; UMP from orotate: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the OMP decarboxylase family. Type 2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.23" evidence="7"/>
    <dbReference type="EMBL" id="NNBL01000021">
        <property type="protein sequence ID" value="PJN07305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN07305">
        <property type="protein sequence ID" value="PJN07305"/>
        <property type="gene ID" value="CG723_34185"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00070">
        <property type="reaction ID" value="UER00120"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004590">
        <property type="term" value="F:orotidine-5'-phosphate decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006207">
        <property type="term" value="P:'de novo' pyrimidine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044205">
        <property type="term" value="P:'de novo' UMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01215">
        <property type="entry name" value="OMPdecase_type2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018089">
        <property type="entry name" value="OMPdecase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011995">
        <property type="entry name" value="OMPdecase_type-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001754">
        <property type="entry name" value="OMPdeCOase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011060">
        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43375">
        <property type="entry name" value="PTHR43375"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00215">
        <property type="entry name" value="OMPdecase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00934">
        <property type="entry name" value="OMPdecase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51366">
        <property type="entry name" value="SSF51366"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02127">
        <property type="entry name" value="pyrF_sub2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00156">
        <property type="entry name" value="OMPDECASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="6 7" id="KW-0456">Lyase</keyword>
    <keyword evidence="5 7" id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OMPdecase" evidence="8">
        <location>
            <begin position="20"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="7">
        <location>
            <position position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001419"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PJN07305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="281" mass="28899" checksum="11620176F5E1DBB7" modified="2018-04-25" version="1">MTVLEPFGARLRRAMDERGPLCVGIDPHAALLSAWGLNDDIDGLERFTRTSVEALADTVAVVKPQSAFFERFGSRGVAVLERAVADLRAAGTLVVMDAKRGDIGSTMAAYAETFLHKDSPLFSDALTVSPYLGYGSLKPAVDLARESGAGLFVLALTSNPEGGEVQHAVRADGRNVGATMLAHLSEENAGETPMGSFGAVVGATLGDLSSYDLDINGPLLAPGIGAQGATPADLPAVFGAAARNVVPNVSRAVLKAGPSVAALRDASVRFADEVRAAVAAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JKG2</accession>
    <name>A0A2M9JKG2_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA polymerase-binding protein RbpA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rbpA</name>
        <name evidence="2" type="ORF">CG723_34450</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Binds to RNA polymerase (RNAP), stimulating transcription from principal, but not alternative sigma factor promoters.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="1">Bind 1 Zn(2+) per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Forms a complex with the RNAP catalytic core and with free principal sigma factors.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the RNA polymerase-binding protein RbpA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000021">
        <property type="protein sequence ID" value="PJN07353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN07353">
        <property type="protein sequence ID" value="PJN07353"/>
        <property type="gene ID" value="CG723_34450"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001000">
        <property type="term" value="F:bacterial-type RNA polymerase core enzyme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045893">
        <property type="term" value="P:positive regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.28.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01483">
        <property type="entry name" value="RbpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038638">
        <property type="entry name" value="RbpA_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025182">
        <property type="entry name" value="RNApol-bd_RbpA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13397">
        <property type="entry name" value="RbpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <feature type="binding site" evidence="1">
        <location>
            <position position="34"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="38"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="56"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="59"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN07353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="124" mass="14097" checksum="E9E4191C9391DD12" modified="2018-04-25" version="1">MSERALRGTRLVVTSYETDRGIDLAPRQAVEYACEKGHRFEMPFSVEAEIPAEWECKVCGAQALLVDGDGPEEKKAKPARTHWDMLMERRTREELEEVLEERLAVLRSGAMNIAVHPRDSRKSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JKN3</accession>
    <name>A0A2M9JKN3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_33500</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000020">
        <property type="protein sequence ID" value="PJN07423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN07423">
        <property type="protein sequence ID" value="PJN07423"/>
        <property type="gene ID" value="CG723_33500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="23"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="64"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="94"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="186"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="222"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="268"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="300"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="342"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="383"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="409"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="432"/>
            <end position="449"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN07423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="452" mass="48101" checksum="F1EA95F9E42C0D24" modified="2018-04-25" version="1">MKVEAPPAAPSTAPPSTGTRRDLVAAAAAVALVTAAVLVGRYIQDHYGTLHVNWAPLYGHWEPHVGPGTPAAISVAVLVVAYGPVVAARLRWRLLLPAVWVASAAWTFSLALIDGWQRGIAGRLTTSYEYLQVIDRFDDVGATLRDFTRHILLHSPDHWPPHVAGHPPAATLTFVGLDRIGLGGGAWAGVWCITVGCTAALAVLVTVRALADERTARRAAPFLALAPAAVWMGTSADGYFAAVAAWSMALLAVAATRGSRWAALGSGLLFGLTCYLSYGLTLIALVAAAVLLTARTVRPLPLFAVGAAVVPVAFTLVGFNWWEAYHLLTERYYQGAGGIRPYGYWIWANLACTVLIVGLATAAGLRRVPGHVLRDRAEPEGRLALVVLGAALALLAADLSGMSKAETERIWLPFAAWLLAATALLPERWRRGWLTAQAVLALLINHLLVTGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JLL2</accession>
    <name>A0A2M9JLL2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">3-oxoacyl-ACP reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CG723_32395</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000018">
        <property type="protein sequence ID" value="PJN07770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN07770">
        <property type="protein sequence ID" value="PJN07770"/>
        <property type="gene ID" value="CG723_32395"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PJN07770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="259" mass="27143" checksum="3D37D75F55C037E8" modified="2018-04-25" version="1">MTENICRRLVGRTAVITGAGSGIGLATARRLASEGANVVCADIDESAGKKAAEDVGGTFVQVDVTDAEQVEALFKTAYDTYGSVDIAFNNAGISPPDDDSILDTGLEAWKRVQEVNLTSVFLCCKAAIPYMRQQGKGSIINTASFVARMGAATSQISYTASKGGVLAMSRELGVQFAREGIRVNALCPGPVNTPLLQELFAKDPERAARRLVHIPVGRFADADEIAAAVAFLASDDSSFVNATDFLVDGGISGAYVTPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-09-29" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JLX0</accession>
    <name>A0A2M9JLX0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CG723_31195</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CB01635</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000017">
        <property type="protein sequence ID" value="PJN07865.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN07865">
        <property type="protein sequence ID" value="PJN07865"/>
        <property type="gene ID" value="CG723_31195"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="24"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="62"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="91"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="116"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="150"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="179"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="260"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="296"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="331"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="416"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="26"/>
            <end position="444"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PJN07865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="472" mass="50003" checksum="C1D655406EAC1560" modified="2018-04-25" version="1">MSATPHLVELAPIIERQRANRRWLLMYAVCCLITFLDGFDFQILSFAATYLKKDFGLTETQLGTLGTVGLFGTMIGALIMGYLADRMGRRPTIIVSVAGFGVFMLGFAQADTYAHLFALRFISGLFLGGVLPLTWALAAEYAPKRFRVTAVSIIMCGYTLGGAAGGPVSNWLIPDYGWRSVFVVGGVCSLLTVLAVLPLLPESVKFLALKARPDSDERISRILSRFQPGLSIEPGTRFTTEAQEQAHSGKRFTPAQLFRGHLAAITPLLWVVYLLSSALIYFLVFWTPMINERMGFSVSAAATIAALASVAGAVAQLFISRFVDRKGAGIILWMPLAAVVCMVTLGSGALAPAVYVAFVIGAKMFVNGGHGGITSIAGTFYPTAIRANGAAWASSVAKIGAMVGPWLGGVILDAGLGAQGAFTVFAVCPAVMVVVLFVFGRVQRRLPAEAEGAISVETPTTGVAPVKTAAAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JM18</accession>
    <name>A0A2M9JM18_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CG723_31425</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000017">
        <property type="protein sequence ID" value="PJN07898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN07898">
        <property type="protein sequence ID" value="PJN07898"/>
        <property type="gene ID" value="CG723_31425"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PJN07898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="238" mass="25535" checksum="57E90497C7ECE89C" modified="2018-04-25" version="1">MSASYGLDFVTSYPQCTYRKDEGGGEDAPMTHATCTFDDEIAPGARVELPEQLVVAVNDKALYERLDLSVDPAGGVTDIDSGDNYVAQEVLADNTADFAVRGTDVMGSAGETVTAEVRFQNEGPAWFGNLGSGDPAAVVEFRVPQGTTVSDAPTECRPRTLTGGYYPNRVGAPRYDCNLPYWVSENTERAFAFQLRVDTVVQDATGPVVVRPVFGEFAFDPDTKNNSAEVVVNATPKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JM59</accession>
    <name>A0A2M9JM59_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">ABC transmembrane type-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CG723_31620</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CB01635</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000017">
        <property type="protein sequence ID" value="PJN07953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN07953">
        <property type="protein sequence ID" value="PJN07953"/>
        <property type="gene ID" value="CG723_31620"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="222"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="286"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="321"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="346"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="403"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="448"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="282"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="48"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="51"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="70"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="149"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="165"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PJN07953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="483" mass="51314" checksum="E76941B69CD48FCE" modified="2018-04-25" version="1">MADHRGCGPPVDRQGDYRPGPRLGARDDRRRVAALLARCGAPVRVRVPSRLVPGRGRHRTHRARPARADPRRTARRVSRPGDARRAPHDPRPAVHHVGAAARHEPGSGPRPARAAARAAAAADPVRLGGRRALLQRGRRGGGLRAPGRRPGAPERRDRPRPAAGHRDRAAHRHGVRPRQPRRRPAVRGGRPARPHPSGDLTVTALTAALAPARRRPRLRPGLFAAGLFLTLVVVAALVPSLLTSYAPDAIRPADFFRSPSAAHWFGTDQNGRDVYTRVVYGAGQSLLIGLGATAISLGLGIVLGLGAALGGRRADFAVGRVLEVLFAFPGLLLALLFIAVFGTGAVTAAIAVGIGEAAGYARLIRSQAATVVRSGYVEAARGLGHSPARVVRRTVLPNVLRPLAALATLGIGQSVVWASSLSFLGLGAQPPAAEWGAMLADGRTFLQYAWWTSFFPGLFIVLTTLSTTVLGRRLQAWLDTRSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JMA4</accession>
    <name>A0A2M9JMA4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">AraC family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_30415</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000016">
        <property type="protein sequence ID" value="PJN08010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08010">
        <property type="protein sequence ID" value="PJN08010"/>
        <property type="gene ID" value="CG723_30415"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="1">
        <location>
            <begin position="196"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN08010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="294" mass="32488" checksum="8CF16BBC3B125B47" modified="2018-04-25" version="1">MGKNGHPAGRPDVRDLEYTPAVGAPAGVEVMELADLLERSRRHGNDPYAPLRPAFHQLIGARERPLRMWVDFVEHELRPGSWLWIRPGQVQRFGPDLVAADGVIVLFQPGFLPPATVSAAHMDPPYEQRPSVLDGSDAEGVRRALDHLVYEYGAMASLPLQAHTEVLRALVSVLVVRLAQARGPAPRPTTASETFRRFHAAVERDHAVTRRVEDYAAALGYSTRTLTRATLAATGRTAKQYVDDRVLLEAKRLLQHSGLTAKKVTVRLGFTDASDFTKFFRLRTGMTPGAFRGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JMM9</accession>
    <name>A0A2M9JMM9_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF402 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_29355</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000015">
        <property type="protein sequence ID" value="PJN08118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08118">
        <property type="protein sequence ID" value="PJN08118"/>
        <property type="gene ID" value="CG723_29355"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.380.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007295">
        <property type="entry name" value="DUF402"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035930">
        <property type="entry name" value="FomD-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04167">
        <property type="entry name" value="DUF402"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF159234">
        <property type="entry name" value="SSF159234"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF402" evidence="1">
        <location>
            <begin position="100"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN08118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="230" mass="26142" checksum="1710BF1EF3DED9DF" modified="2018-04-25" version="1">MTDRTSILAGETDGSVGRWAPGSRILWRYRTNGGDGFHICRPVTVVEDSAELLAVWLAPGTECVRPVLADGTPVHEEPLATRYTKPRTVLRDRWFGTGVLKLARPGEPWSVWLFWEPGWRFRNWYVNLEQPRVRWAGGVDSEDHFLDLSVYADRTWRWHDEDEFAQAQIAGLMSAAQAESVRRAGRAAVEVIEGWGHPFPDGWQHWRPDPAWPVPALPGDWNRTPAHVSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-05-25" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JN11</accession>
    <name>A0A2M9JN11_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_29695</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000015">
        <property type="protein sequence ID" value="PJN08263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08263">
        <property type="protein sequence ID" value="PJN08263"/>
        <property type="gene ID" value="CG723_29695"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046095">
        <property type="entry name" value="DUF6113"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19608">
        <property type="entry name" value="DUF6113"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="33"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="63"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="86"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN08263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="126" mass="12137" checksum="BAF5B667411FE13D" modified="2018-04-25" version="1">MGTGPDAGRIAVLAGLLVLGALVGVAGSLVQGGLFPGGLLLALLGAAGAFLGGARATGTRGGAVAPAVGWAVTVILLTSTRPEGDFLFGAGTASYLFLLGGMAVAVMCATLGLPRQPPRPAARLGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JN18</accession>
    <name>A0A2M9JN18_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_30095</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000015">
        <property type="protein sequence ID" value="PJN08254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08254">
        <property type="protein sequence ID" value="PJN08254"/>
        <property type="gene ID" value="CG723_30095"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="48"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN08254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="78" mass="8472" checksum="877E9F344E25F7C5" modified="2018-04-25" version="1">MAALLWLLIPLFAAVGAGLWGSWAARNRRTGDVSELNGYVRFREAMERSHTGTEADPLDPEADALPPVESRTDAPAVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JNE0</accession>
    <name>A0A2M9JNE0_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 12">Aspartate-semialdehyde dehydrogenase</fullName>
            <shortName evidence="12">ASA dehydrogenase</shortName>
            <shortName evidence="12">ASADH</shortName>
            <ecNumber evidence="7 12">1.2.1.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Aspartate-beta-semialdehyde dehydrogenase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="primary">asd</name>
        <name evidence="14" type="ORF">CG723_28535</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">CB01635</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Catalyzes the NADPH-dependent formation of L-aspartate-semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl-4-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 12">
            <text>L-aspartate 4-semialdehyde + NADP(+) + phosphate = 4-phospho-L-aspartate + H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:24284"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57535"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:537519"/>
            <dbReference type="EC" id="1.2.1.11"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 12">Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; (S)-tetrahydrodipicolinate from L-aspartate: step 2/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 12">Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; L-homoserine from L-aspartate: step 2/3.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4 12">Amino-acid biosynthesis; L-threonine biosynthesis; L-threonine from L-aspartate: step 2/5.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6 12">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5 12">Belongs to the aspartate-semialdehyde dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.11" evidence="7 12"/>
    <dbReference type="EMBL" id="NNBL01000014">
        <property type="protein sequence ID" value="PJN08337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08337">
        <property type="protein sequence ID" value="PJN08337"/>
        <property type="gene ID" value="CG723_28535"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00034">
        <property type="reaction ID" value="UER00016"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00050">
        <property type="reaction ID" value="UER00463"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00051">
        <property type="reaction ID" value="UER00464"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004073">
        <property type="term" value="F:aspartate-semialdehyde dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071266">
        <property type="term" value="P:'de novo' L-methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019877">
        <property type="term" value="P:diaminopimelate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009097">
        <property type="term" value="P:isoleucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009089">
        <property type="term" value="P:lysine biosynthetic process via diaminopimelate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009088">
        <property type="term" value="P:threonine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02121">
        <property type="entry name" value="ASADH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012080">
        <property type="entry name" value="Asp_semialdehyde_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005986">
        <property type="entry name" value="Asp_semialdehyde_DH_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000534">
        <property type="entry name" value="Semialdehyde_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012280">
        <property type="entry name" value="Semialdhyde_DH_dimer_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01118">
        <property type="entry name" value="Semialdhyde_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02774">
        <property type="entry name" value="Semialdhyde_dhC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00859">
        <property type="entry name" value="Semialdhyde_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01296">
        <property type="entry name" value="asd_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="9 12" id="KW-0220">Diaminopimelate biosynthesis</keyword>
    <keyword evidence="10 12" id="KW-0457">Lysine biosynthesis</keyword>
    <keyword evidence="11 12" id="KW-0486">Methionine biosynthesis</keyword>
    <keyword evidence="12" id="KW-0521">NADP</keyword>
    <keyword evidence="12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 12" id="KW-0791">Threonine biosynthesis</keyword>
    <feature type="domain" description="Semialdhyde_dh" evidence="13">
        <location>
            <begin position="8"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-thioester intermediate" evidence="12">
        <location>
            <position position="133"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="12">
        <location>
            <position position="258"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="15"/>
            <end position="18"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="43"/>
            <end position="44"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="103"/>
        </location>
        <ligand>
            <name>phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="160"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="163"/>
            <end position="164"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="251"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="331"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00010584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00013120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="PJN08337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="355" mass="37517" checksum="F29E07E46B8CD924" modified="2018-04-25" version="1">MAQTDRPTLAVVGATGAVGAVMLQILSQHADIWGEIRLIASSRSAGRKLAVRGEEVEVMALCEEVFDGVDVAMFDVPDEISAQWAPVAASKGAVVVDNSAAFRMDPDVPLVVPEVNPHAARVRPRGIVANPNCTTLSMIVAVGALHAEFGLRELVVSSYQAVSGAGRAGIDTLRQQMSLVAGTELGTHPGDVRRAVGDNTGPFLEPVALNVVPWAGSLREDGWSSEEMKVRDESRKILGLPDLKVAVTCVRVPVVTTHSLTVHARFQSEVTVDKAREILATAPGVVLFDNPAAGEFPTPADVVGTDPTWVGRVRRSLDDPAGLEFFVCGDNLRKGAALNTAQIAELVAQEFPPAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JPG7</accession>
    <name>A0A2M9JPG7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">AraC family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CG723_27195</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000012">
        <property type="protein sequence ID" value="PJN08768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08768">
        <property type="protein sequence ID" value="PJN08768"/>
        <property type="gene ID" value="CG723_27195"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01310">
        <property type="entry name" value="TatD_DNAse"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001130">
        <property type="entry name" value="TatD-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01026">
        <property type="entry name" value="TatD_DNase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005902">
        <property type="entry name" value="DNase_TatD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PJN08768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="293" mass="31106" checksum="C8CDFE359D29B7AB" modified="2018-04-25" version="1">MSSDRSKDVTPPPLPAPLAVPVADSHTHLDMQSGTVEEGLAKAASVGVTTVVQVGCDVNGSRWAADTAAAHPSVHATVALHPNEAPRIVLGDPDGWSRQGERPAGGDAALDEALAEIDRLAALPHVKGVGETGLDHFRTGPEGIAAQERSFRAHIEIAKRHGKALVIHDRDAHDDVLRILKEEGAPERTVFHCYSGDAEMARICAENGYFMSFAGNITFKNAQPLRDALAVAPRELVLVETDAPFLTPAPYRGRPNAPYLIPVTLRAMAAVKGLDEDTLAAAVSANTARAFDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JPH8</accession>
    <name>A0A2M9JPH8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MarR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_27280</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000012">
        <property type="protein sequence ID" value="PJN08782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08782">
        <property type="protein sequence ID" value="PJN08782"/>
        <property type="gene ID" value="CG723_27280"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000835">
        <property type="entry name" value="HTH_MarR-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023187">
        <property type="entry name" value="Tscrpt_reg_MarR-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12802">
        <property type="entry name" value="MarR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00598">
        <property type="entry name" value="HTHMARR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00347">
        <property type="entry name" value="HTH_MARR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01117">
        <property type="entry name" value="HTH_MARR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50995">
        <property type="entry name" value="HTH_MARR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH marR-type" evidence="1">
        <location>
            <begin position="23"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN08782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="165" mass="18594" checksum="6929D763743AB5F2" modified="2018-04-25" version="1">MEDEVDRLVAAWRRERPDLDVEPLEVLSRVSRLARHLDRARRLAFAEHQLEPWEFDVLTSLRRAGAPYQLSPGQLLTQTLVTSGTMTNRIDRLAKKGLVERLPDPSDRRGVLVRLTTEGQDRADQALAGLLAQERAILAELSRTQRGELAGLLRQLTAPFDNIPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JPI4</accession>
    <name>A0A2M9JPI4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DNA-binding response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CG723_27275</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000012">
        <property type="protein sequence ID" value="PJN08781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08781">
        <property type="protein sequence ID" value="PJN08781"/>
        <property type="gene ID" value="CG723_27275"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="5"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="domain" description="HTH luxR-type" evidence="3">
        <location>
            <begin position="174"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PJN08781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="249" mass="26187" checksum="C88F5284531CB88A" modified="2018-04-25" version="1">MVRIRVLVVDDHRIFAESLAAALAAEPDVDVSAAGSGPAALRCMDRAAAEGRRFDVLLVDADLGAALHGPRPATAVPDTAPGQDGLVDGISLVAGVRSGQPTVRTVVLAEKDDPRRAALALQAGASGWVAKDCSLSRLLTVIRGVLRDETHLPPALLTSVLRELTAARKHRTDSERLVESLTPREREVLRCMVAGLGRKAVAERLFLSPHTVRTHMQNVLGKLGVHSTLAAVALARRAGVGPADLEAAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JPT7</accession>
    <name>A0A2M9JPT7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Peptidase propeptide and YpeB domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CG723_25500</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000011">
        <property type="protein sequence ID" value="PJN08855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08855">
        <property type="protein sequence ID" value="PJN08855"/>
        <property type="gene ID" value="CG723_25500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025711">
        <property type="entry name" value="PepSY"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03413">
        <property type="entry name" value="PepSY"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014715274" evidence="2">
        <location>
            <begin position="24"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="domain" description="PepSY" evidence="3">
        <location>
            <begin position="68"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="domain" description="PepSY" evidence="3">
        <location>
            <begin position="141"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="30"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="196"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="31"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="198"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PJN08855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="257" mass="26262" checksum="A5C147BDF5A9DAD5" modified="2018-04-25" version="1">MKRNIVIATIAAVALIGGGTATAVAVSGGDDSTAAGTSTASRGTGSTGSAAGHDDDRAEHVTELKTAKVTASDAIAAALKSVPGTAVSAELDDENDRVVWEVEVLNGTTWHDVLVDPASGKVTGSHTSRHDDTARVTAVLKDAKTTAQDAARAAAVKGTVTEIDLDDDGTAHAWEAETTAANGTDADWRVDLRSGAVTPDRSSHDDGDDDHATRAPHDAGDDHGHDNTATHDAGDDHGNHGRGHDSDDDHGHHGDDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JQ02</accession>
    <name>A0A2M9JQ02_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CG723_25990</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000011">
        <property type="protein sequence ID" value="PJN08936.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_005312030.1">
        <property type="nucleotide sequence ID" value="NZ_NNBL01000011.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08936">
        <property type="protein sequence ID" value="PJN08936"/>
        <property type="gene ID" value="CG723_25990"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046086">
        <property type="entry name" value="DUF6104"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19599">
        <property type="entry name" value="DUF6104"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PJN08936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="60" mass="7293" checksum="D15C8F8118EDA283" modified="2018-04-25" version="1">MYFTDRGIEELEKRRGEEEVTFEWLAEQLRTFVDLNPDFEVPVERLATWLARLDDEDDEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JQ11</accession>
    <name>A0A2M9JQ11_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GNAT family N-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_26060</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000011">
        <property type="protein sequence ID" value="PJN08950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08950">
        <property type="protein sequence ID" value="PJN08950"/>
        <property type="gene ID" value="CG723_26060"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="6"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN08950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="161" mass="17509" checksum="613211BBFA3DCD7E" modified="2018-04-25" version="1">MTDAQVSVRHARPGDLPEVARLAAEHAAFEKADPPAPGLADRLHTLLFTTATPRLRCLVAELADGTLAGYATCEPAISTWDGCEYLHMDCLYLRPGHRGLGLGPLMMDAVAAGARALGIAEIQWQTPVWNDGAIRFYRRLGAREKDKLRFSRPSSSDLVGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JQ17</accession>
    <name>A0A2M9JQ17_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="15">2-oxoglutarate dehydrogenase E1 component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CG723_25985</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">CB01635</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(R)-N(6)-dihydrolipoyl-L-lysyl-[2-oxoglutarate dehydrogenase complex component E2] + succinyl-CoA = (R)-N(6)-(S(8)-succinyldihydrolipoyl)-L-lysyl-[2-oxoglutarate dehydrogenase complex component E2] + CoA</text>
            <dbReference type="Rhea" id="RHEA:15213"/>
            <dbReference type="Rhea" id="RHEA-COMP:10581"/>
            <dbReference type="Rhea" id="RHEA-COMP:10582"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57292"/>
            <dbReference type="ChEBI" id="CHEBI:83100"/>
            <dbReference type="ChEBI" id="CHEBI:83120"/>
            <dbReference type="EC" id="2.3.1.61"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>(R)-N(6)-lipoyl-L-lysyl-[dihydrolipoyllysine-residue succinyltransferase] + 2-oxoglutarate + H(+) = (R)-N(6)-(S(8)-succinyldihydrolipoyl)-L-lysyl-[dihydrolipoyllysine-residue succinyltransferase] + CO2</text>
            <dbReference type="Rhea" id="RHEA:12188"/>
            <dbReference type="Rhea" id="RHEA-COMP:10483"/>
            <dbReference type="Rhea" id="RHEA-COMP:10484"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:83099"/>
            <dbReference type="ChEBI" id="CHEBI:83120"/>
            <dbReference type="EC" id="1.2.4.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">Carbohydrate metabolism; tricarboxylic acid cycle; succinyl-CoA from 2-oxoglutarate (dehydrogenase route): step 1/1.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000011">
        <property type="protein sequence ID" value="PJN08935.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08935">
        <property type="protein sequence ID" value="PJN08935"/>
        <property type="gene ID" value="CG723_25985"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00223">
        <property type="reaction ID" value="UER00997"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004149">
        <property type="term" value="F:dihydrolipoyllysine-residue succinyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004591">
        <property type="term" value="F:oxoglutarate dehydrogenase (succinyl-transferring) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030976">
        <property type="term" value="F:thiamine pyrophosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11610">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001078">
        <property type="entry name" value="2-oxoacid_DH_actylTfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032106">
        <property type="entry name" value="2-oxogl_dehyd_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011603">
        <property type="entry name" value="2oxoglutarate_DH_E1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001017">
        <property type="entry name" value="DH_E1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031717">
        <property type="entry name" value="KGD_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042179">
        <property type="entry name" value="KGD_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005475">
        <property type="entry name" value="Transketolase-like_Pyr-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23152">
        <property type="entry name" value="PTHR23152"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00198">
        <property type="entry name" value="2-oxoacid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16078">
        <property type="entry name" value="2-oxogl_dehyd_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00676">
        <property type="entry name" value="E1_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16870">
        <property type="entry name" value="OxoGdeHyase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02779">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000157">
        <property type="entry name" value="Oxoglu_dh_E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00861">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00239">
        <property type="entry name" value="2oxo_dh_E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="11" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0786">Thiamine pyrophosphate</keyword>
    <keyword evidence="11" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="Transket_pyr" evidence="14">
        <location>
            <begin position="922"/>
            <end position="1115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="63"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1238"/>
            <end position="1259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00033664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="PJN08935.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="1270" mass="138807" checksum="F65E7E8D1CAFD995" modified="2018-04-25" version="1">MSPQSPSNSSTSTDQEGQGKSPAAAFGPNEWLVDEIYQQYLQDPNSVDRAWWDFFADYKPGAPAQPTTGAPAQGSGPVGTAGTAAAGAAGTAAAPAAPAAPAPAAAPAPAPAPAAPVAKPAAAAPAKPAAAAVKAPAPAKAQPATEAAGGPEFVTLRGPSAAVAKNMNASIEVPTATSVRAVPVKLLFDNRIVINNHLKRARGGKISFTHLIGYAMVQAIKAMPSMNYSFAEKDGKPTLVKPEHINFGLAIDLVKPNGDRQLVVAGIKKAETLNFFEFWQAYEDIVRRARDGKLGMDDFTGVTVSLTNPGGLGTVHSVPRLMPGQSVIMGVGSMDYPAEFQGTSQDTLNKLGISKVMTLTSTYDHRVIQGAASGEFLRVVANFLLGEGEFYDEIFKALRIPYEPVRWFKDIDASHDDDVTKAARVFELIHSFRVRGHVMADTDPLEYRQRKHPDLDIAEHGLTLWDLEREFAVGGFAGKTMMKLRDILGVLRDSYCRTTGIEYMHIQDPKQRKWLQDRVERPHTKPEREEQLRILRRLNAAEAFETFLQTKYVGQKRFSLEGGESVIPLLDAVIDSAAESRLDEVVIGMAHRGRLNVLANIVGKSYAQIFREFEGNLDPKSMHGSGDVKYHLGAEGTFTGLDGEQIKVSLAANPSHLETVDPVIEGIVRAKQDIINKGGTDFTVLPVALHGDAAFAGQGVVAETLNMSQLRGYRTGGTVHIVINNQVGFTAAPESSRSSMYATDVARMIEAPIFHVNGDDPEAVVRVARLAFEFRQAFNKDVVIDLICYRRRGHNESDNPAFTQPLMYDLIDKKRSVRKLYTESLIGRGDITLEEAEQALQDFQGQLEKVFAEVREATAHPVAAPSADPQAEFPVAVSTAISQETVKRIAESQVNIPDRVTVHPRLLPQLQRRAAMIEDGTIDWGMGETLAIGSLLLEGTPVRLSGQDSRRGTFGQRHAVLIDRETGEDFTPLLYLSDDQARYNVYDSLLSEYAVMGFEYGYSLARPESLVMWEAQFGDFVNGAQTVVDEYISAAEQKWGQTSGVTLLLPHGYEGQGPDHSSARPERFLQLCAQNNMTVAMPTLPSNYFHLLRWQVHNPHHKPLVVFTPKSMLRLKAAASKAEEFTEGGFRPVIGDSSVDPAAVRKVVFCAGKVYYDLEAERQKRGVTDTAIIRIERLYPLPGTELQAEISKYPNAEKYLWAQEEPANQGAWPFIALNLIDHLDLAVGADVPHGERLRRISRPHGSSPAVGSAKRHQAEQEQLVREVFEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JQF7</accession>
    <name>A0A2M9JQF7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Aspartate aminotransferase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_24670</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000010">
        <property type="protein sequence ID" value="PJN09113.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN09113">
        <property type="protein sequence ID" value="PJN09113"/>
        <property type="gene ID" value="CG723_24670"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044249">
        <property type="term" value="P:cellular biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="CDD" id="cd00610">
        <property type="entry name" value="OAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005814">
        <property type="entry name" value="Aminotrans_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00202">
        <property type="entry name" value="Aminotran_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000521">
        <property type="entry name" value="Transaminase_4ab_Lys_Orn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00600">
        <property type="entry name" value="AA_TRANSFER_CLASS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="1 2" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN09113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="450" mass="49285" checksum="6AAB4F2D976EB10B" modified="2018-04-25" version="1">MTLTPAQQLAATDRAHIIHPYLPGTAEERVVMTEGKGCRLTDAEGRSYLDATGGLWLAQVGHGRKEIADVAHAQMQQLEYFTSFWEFSNDKAIQLAERLTTLAPDNLNHVYFTSGGSEGNEAAIKMARYYHHRRGEGSRTWILARDKAYHGIGYGGGSATGFPVYHEGFAPMMPHVSHLTPPWPYRTELYGNADPTDFLIAELEGRIAEIGASNIAAMIGEPIMGVGGMLVPPADYWPRVREVLDRHGILLIFDEVVTAYGRVGEWFAAQHFNVKPDIITTAKGITSGYTPLGALLVSDEVTEALLQDHGFPMGYTYNGHPVAAAVALANLDIIERENLLPRAITMGEHLHTQLADELGDLPIVGEIRSVGMMLAVELVADRETRTPLPLNPARMPHDVIRKETGVIVRDSAHSLVLSPPLIMTEQEAKEAATAMRSVLERTTPTGEITK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JQN7</accession>
    <name>A0A2M9JQN7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">4-hydroxyphenylacetate 3-hydroxylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CG723_24640</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000010">
        <property type="protein sequence ID" value="PJN09107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN09107">
        <property type="protein sequence ID" value="PJN09107"/>
        <property type="gene ID" value="CG723_24640"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016627">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004925">
        <property type="entry name" value="HpaB/PvcC/4-BUDH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024719">
        <property type="entry name" value="HpaB/PvcC/4-BUDH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024674">
        <property type="entry name" value="HpaB/PvcC/4-BUDH_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36117">
        <property type="entry name" value="PTHR36117"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03241">
        <property type="entry name" value="HpaB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11794">
        <property type="entry name" value="HpaB_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000331">
        <property type="entry name" value="HpaA_HpaB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="SSF47203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="SSF56645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HpaB_N" evidence="3">
        <location>
            <begin position="4"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="domain" description="HpaB" evidence="2">
        <location>
            <begin position="278"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="146"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="149"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF11794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PJN09107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="490" mass="54743" checksum="C655FE3A84852B90" modified="2018-04-25" version="1">MIRTGDQYRESIRDGRDVWMNGEKVTDVTTHPAFKPLVDIRARIYDMAHDPQTRDSMTYKDETTGEVNAIQQKPPRTREDWDAKRAATDAVLSDVGGVVTRVGDETIGEVWSLIDGQDVLNAINPAYAENVKRHIDHALYADPFHVSANTDPKGDRSKRPQDQDPDMLLHVVRETDSGIVVRGAKYETAAAYSNQAFTKPTIANWGDSELSDYALGFIADMGSPGLKYICRTGFAGTKPPADYPVSSRFDEVDTLVVFDDVEIPWENVLFYRDTKAATFIRATLHRYSAFAFTQRNLRLADLMIGAALWNVKQTGLEKQQAVQEKLATLACYREGINAHLTASIAMAEPSPGGLLMPNQSLLYTGRVLACSQLHEMMHIARELCGGQICITPDKASFDHPDTKPWLDKFYSINEHWVAEDRRKLLAYARDLLNSDYAGHRLTFQLFAQSPPFAHLGAVYRNFDWEGPLDLVKDAAGLSDNVLGTLGRKAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JQV9</accession>
    <name>A0A2M9JQV9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_23215</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000009">
        <property type="protein sequence ID" value="PJN09266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN09266">
        <property type="protein sequence ID" value="PJN09266"/>
        <property type="gene ID" value="CG723_23215"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="54"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN09266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="84" mass="8609" checksum="DA448E307AAF0A76" modified="2018-04-25" version="1">MGLRPVFATTARAGRLATVRGPQQPAAALGRAPLDAGDLDAVDVGVLLQVPDDVVPRDPAAGRTRDGQSAKPRSEACMAQMAST</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JQY4</accession>
    <name>A0A2M9JQY4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ethyl tert-butyl ether degradation protein EthD</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_23270</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000009">
        <property type="protein sequence ID" value="PJN09275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN09275">
        <property type="protein sequence ID" value="PJN09275"/>
        <property type="gene ID" value="CG723_23270"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009799">
        <property type="entry name" value="EthD_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07110">
        <property type="entry name" value="EthD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02118">
        <property type="entry name" value="TIGR02118"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EthD" evidence="1">
        <location>
            <begin position="12"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN09275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="106" mass="12136" checksum="4498D77B6144B985" modified="2018-04-25" version="1">MYNLVLLAARPPEWTHERFIDWWRGDHAELTYRLPGLRAWRHTEIDQALEPRSEGWDGISVLSFDSPEALKKALASPEWADAVAQVGDMKGRRIAVMGREAEMFTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JR68</accession>
    <name>A0A2M9JR68_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CG723_23890</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000009">
        <property type="protein sequence ID" value="PJN09371.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN09371">
        <property type="protein sequence ID" value="PJN09371"/>
        <property type="gene ID" value="CG723_23890"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PJN09371.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="290" mass="32292" checksum="9232036B70059075" modified="2018-04-25" version="1">MSEAVRRPTPRPTFDHPTVIRQQDAAHHLWGDEDGSGHVSDRVYVSSSCLHVLQFTLPPRGRYVHSAMNPTVFAADVAYTVLEGELILIDPEHGEVRPLAAGDIGFFRRDTWTHAVNPRHEPVRVLEFFSPPPSHDTASPYARSQPLLGETRYRDTRWSGRWPAARADREAASRIHVVREDGHLHWLPEDDGGHLAGTAVDTEYLTVTRGQLTPGHRGQEHVTADETVLYVTEGTVHLHLPGFAGPAWHRVEPHDAAYLPAGTRYQLMDFDGAGAAYWAGAGRVPEGWRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JRH1</accession>
    <name>A0A2M9JRH1_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Glucosamine_iso domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_23970</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000009">
        <property type="protein sequence ID" value="PJN09387.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN09387">
        <property type="protein sequence ID" value="PJN09387"/>
        <property type="gene ID" value="CG723_23970"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004342">
        <property type="term" value="F:glucosamine-6-phosphate deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006044">
        <property type="term" value="P:N-acetylglucosamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006148">
        <property type="entry name" value="Glc/Gal-6P_isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004547">
        <property type="entry name" value="Glucosamine6P_isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11280">
        <property type="entry name" value="PTHR11280"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01182">
        <property type="entry name" value="Glucosamine_iso"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="SSF100950"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glucosamine_iso" evidence="1">
        <location>
            <begin position="73"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN09387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="328" mass="34981" checksum="40A58F5122841EDA" modified="2018-04-25" version="1">MCPTICSPADRASRLKCRGCVRPSRCCRALPARRSISCAATLAALRTARLAYLVQLVCEGVALVRVLPTVFPDPYVLGRALAAMVADGLEEAAREGRPYVLGCPGGRSARTTYRALAGEVARRGLDLRPLTVAMMDEYVVEGAVPGEFRPVDHRLPHSCLRFGREEITGPLNTAAGTGRSIEPDRLWVPDPSDPESYDKRLEDLGGIDLFILATGAGDGHVAFNAPGTPAGTRTHVARLAEQTRRDNLVTFPTFDGLDDVPLHGVTVGVGTIREQSRRTVLVAHGPDKAAAAGRLAAAVSYEPDWPATVLSDCARPDLFLDASAAHAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JRV0</accession>
    <name>A0A2M9JRV0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_22825</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 12 (cellulase H) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000008">
        <property type="protein sequence ID" value="PJN09572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN09572">
        <property type="protein sequence ID" value="PJN09572"/>
        <property type="gene ID" value="CG723_22825"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008810">
        <property type="term" value="F:cellulase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013319">
        <property type="entry name" value="GH11/12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002594">
        <property type="entry name" value="GH12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34002">
        <property type="entry name" value="PTHR34002"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01670">
        <property type="entry name" value="Glyco_hydro_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="SSF49899"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014889849" evidence="2">
        <location>
            <begin position="35"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN09572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="239" mass="25517" checksum="3A8E9C6C93039BE2" modified="2018-04-25" version="1">MAPTARHSLRRRTLLGSVLAGGALLALAASPAQAAIWSSSDQWGNYTTSDGYTLYNNIWGSGAGAQTIWANSSSNWGVWADHPNTGGIKSYPNAKKVVNKSISSLSSLTSSYNVTVPSSGAYNTSYDIWDSDYDYEVMLWVNYNGAVGPLGTSQGNVTLGGHTWTVYKGNNGANEVYSFLRTSDSTSGTVDILPILKWIKDTKGWWGDETIGDVQFGYEITSSAGGLGFTTNSFKVSSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JRY5</accession>
    <name>A0A2M9JRY5_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SGL domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_23085</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000008">
        <property type="protein sequence ID" value="PJN09612.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN09612">
        <property type="protein sequence ID" value="PJN09612"/>
        <property type="gene ID" value="CG723_23085"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013658">
        <property type="entry name" value="SGL"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08450">
        <property type="entry name" value="SGL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014832023" description="SGL domain-containing protein" evidence="1">
        <location>
            <begin position="34"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="domain" description="SGL" evidence="2">
        <location>
            <begin position="67"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN09612.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="344" mass="35689" checksum="874881B758FF5663" modified="2018-04-25" version="1">MTTYRTPRALTGLAAVGLLALTGCGTQTGGAPASENPTPSGEGRNIRATQLAHVTDVHEATGMTLLEGPVLYEDGRLYVVDVTAPPGEPKLISVDVATGEHKGVYTDKSGAYTSAQTSPHDGRLYLTDFATGSIVSLAPDGSDPRTFFSGAVDGSKMTPDDIAFDDEGNLYVSDAHGTEPDETDGRMVRIDRDGTKSTVLADGLAQPNGIMFDPGLHGLWISELAEDTISYLLLDAGKAAVTSQHEAIHVDGGLAQTDSIAVDADGNLYQALHGRPAIAVYSKYGARLATVEVPAKNAEGLKSATNVAITPGGTKAYMTVSGPDGGYVFTFTALAKGIRQSNSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JS11</accession>
    <name>A0A2M9JS11_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CG723_23060</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000008">
        <property type="protein sequence ID" value="PJN09643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN09643">
        <property type="protein sequence ID" value="PJN09643"/>
        <property type="gene ID" value="CG723_23060"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006764">
        <property type="entry name" value="SAM_dep_MeTrfase_SAV2177_type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04672">
        <property type="entry name" value="Methyltransf_19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017393">
        <property type="entry name" value="MTase_SAV2177"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PJN09643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="267" mass="28396" checksum="0C30629EB7155C4F" modified="2018-04-25" version="1">MRQDGFHAGKIDTSKPHPARIYDYLLGGKDHYEVDQRAGDELAAAAPEVRIGLRANRAFLGRAVRHVVDSGVRQILDIGTGLPTAPNVHETAQAVAPDVRVAYVDNDPIVSAHAGALLSGSSATGVALADLRDPRSVVDHPGVRQVIDFDEPVALLLVAVLHFLTDADEPERIVATLRDALAPGSFLVLSHATGDFADRSAAQAVYSKATATLNLRSRAEVERFFTGFEPVEPGLAQAPFWRPDIPPPAGSEGIGFYGGVGRKTGSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JS36</accession>
    <name>A0A2M9JS36_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CG723_20980</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000007">
        <property type="protein sequence ID" value="PJN09685.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN09685">
        <property type="protein sequence ID" value="PJN09685"/>
        <property type="gene ID" value="CG723_20980"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PJN09685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="65" mass="7277" checksum="FD67C2658ECCE616" modified="2018-04-25" version="1">MKTVKSAMFRNIANPRRTTLMHLKDADELQTAPELPEYSVELPAQTANPRRAILMEAPEQTPVAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-09-29" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JSG3</accession>
    <name>A0A2M9JSG3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Amino-acid racemase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_21225</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000007">
        <property type="protein sequence ID" value="PJN09727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN09727">
        <property type="protein sequence ID" value="PJN09727"/>
        <property type="gene ID" value="CG723_21225"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001608">
        <property type="entry name" value="Ala_racemase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029066">
        <property type="entry name" value="PLP-binding_barrel"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01168">
        <property type="entry name" value="Ala_racemase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51419">
        <property type="entry name" value="SSF51419"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ala_racemase_N" evidence="1">
        <location>
            <begin position="34"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN09727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="387" mass="40814" checksum="0E82ABF0AF69BB7D" modified="2018-04-25" version="1">MFLDSLLTRNPELVDAAADLHRRGAIPPDTYVMDLDAIESNAALLAAEADRLGLTLWFVVKQLGRNPELIRAIARHIPKYAAIDAQEARTLHAAGAQAGNLGHLVQIPRRSLPEMLAWRPETVTVLDVDNARAVSDAARAQGFVQDVLVRLEGAEGAVYPGQEGGVPLGALDDFAAAAEELPGVRIAGVTAFPCVLCDPATGTPRLTDNFELAVKARELLTSRGHEGLKLSAPSATSMATLPLLAEHGATHGEPGHSLTGTTPLHARDAGQPERPAYVYVTEVAHTLADGRPAVFGGGFYPRAHIGSALLPRTGRRLAVQDAPAENIDYYRLLDAPDPGRAPAAGDTALLAFRTQIFVTRSTVAVVAGLSSGSPRLTGLYDAQGKAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JSJ6</accession>
    <name>A0A2M9JSJ6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_21875</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000007">
        <property type="protein sequence ID" value="PJN09840.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN09840">
        <property type="protein sequence ID" value="PJN09840"/>
        <property type="gene ID" value="CG723_21875"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="35"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN09840.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="150" mass="17057" checksum="C121548181443F59" modified="2018-04-25" version="1">MRAKLTYLVTALVLVFYFVLVGSRGLLLIEQGTLLTVTFGVAVLILPVIGLWFLWANTQFVRKANRLADLLEAEGGLPVDELRRDQYGRIDRDSADEVFARRKAETEDTPGDWRCWFRLAVAYRDARDTPRARKAMQRAIALQEGRTVSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JSK2</accession>
    <name>A0A2M9JSK2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CG723_21795</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000007">
        <property type="protein sequence ID" value="PJN09828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN09828">
        <property type="protein sequence ID" value="PJN09828"/>
        <property type="gene ID" value="CG723_21795"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036689">
        <property type="entry name" value="ESAT-6-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010310">
        <property type="entry name" value="T7SS_ESAT-6-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06013">
        <property type="entry name" value="WXG100"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140453">
        <property type="entry name" value="SSF140453"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PJN09828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="113" mass="12635" checksum="62FE89B8044387D4" modified="2018-04-25" version="1">MAAQGQRLSDQEMIALERKISEKFDNIKSTVHRLQGTIDSLEGNWKGIGANAFNTKQHEINTSMVKIGNILVKFLDAMTGTRKIKDDSEDHVRQQVNKINVYDGAPKSTLSGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JSK5</accession>
    <name>A0A2M9JSK5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Dynein regulation protein LC7</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_20950</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000007">
        <property type="protein sequence ID" value="PJN09850.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN09850">
        <property type="protein sequence ID" value="PJN09850"/>
        <property type="gene ID" value="CG723_20950"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004942">
        <property type="entry name" value="Roadblock/LAMTOR2_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03259">
        <property type="entry name" value="Robl_LC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00960">
        <property type="entry name" value="Robl_LC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Robl_LC7" evidence="1">
        <location>
            <begin position="9"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN09850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="137" mass="14333" checksum="9D8BF97CC02E9766" modified="2018-04-25" version="1">MSQAAQNLNWLITNFVDNTPGVSHTVVVSADGLLLAMSEGFPRDRADQLAAVASGLTSLTAGASRIFEGGSVNQTVVEMERGFLFLMSISDGSSLAVLAHPEADIGLVGYEMALLVDRAGTVLTPDLRAELQGSLLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JSM8</accession>
    <name>A0A2M9JSM8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">PspC domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CG723_19265</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CB01635</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000006">
        <property type="protein sequence ID" value="PJN09884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN09884">
        <property type="protein sequence ID" value="PJN09884"/>
        <property type="gene ID" value="CG723_19265"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007168">
        <property type="entry name" value="Phageshock_PspC_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04024">
        <property type="entry name" value="PspC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="33"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="domain" description="PspC" evidence="7">
        <location>
            <begin position="4"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PJN09884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="66" mass="7207" checksum="DC971B883B665479" modified="2018-04-25" version="1">MTALARPTNGRMIGGVCAALARRFGTSATTMRVIFVLSCLLPGPQFLLYIALWILLPSEGKVRQAW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JSP5</accession>
    <name>A0A2M9JSP5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CG723_21745</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000007">
        <property type="protein sequence ID" value="PJN09862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN09862">
        <property type="protein sequence ID" value="PJN09862"/>
        <property type="gene ID" value="CG723_21745"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PJN09862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="121" mass="13158" checksum="1521C6CF844E5EEE" modified="2018-04-25" version="1">MRNDGATIAQIADESVPRLEQGGPVRVLKKTEIGTPDLPGLTDSPGIVQNLVLSTTLRGEPVELCQSQVYLGMEDVRNPAQRAVIEIVLTATQNQLGQVIEDYKEFLRTVRQADDSVGEAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JU43</accession>
    <name>A0A2M9JU43_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CG723_18705</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CB01635</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000005">
        <property type="protein sequence ID" value="PJN10394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN10394">
        <property type="protein sequence ID" value="PJN10394"/>
        <property type="gene ID" value="CG723_18705"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="7"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="67"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="103"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="139"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="234"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="68"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PJN10394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="273" mass="29367" checksum="973657AFE75F16D6" modified="2018-04-25" version="1">MSKQRPNYLAGLGSVVWLLVVGAPLYVLVSASVQSRADYGASGPLSLPRHFTLRNYIDDFSTGFGRYFLNTVIVTVCVVAIVLVVVPPLSYSIVRSRGRVTTAVFRLFLLGLAIPAQAVIVPMFYVISKAGLYDNLIGVILPTAAFSLPMCALVLTGVMRDITPDLYEAMAIDGASSWRVFGQLVLPLSRGGLATIAVFSALQAWNGFLFPLVLTQSDSTKVITLGLYNFRTQYGINVPGLLAAVVLSMVPVLLVYLFARRTLVQGLMGVGGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JUD7</accession>
    <name>A0A2M9JUD7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Aminoglycoside phosphotransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_18315</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000005">
        <property type="protein sequence ID" value="PJN10494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN10494">
        <property type="protein sequence ID" value="PJN10494"/>
        <property type="gene ID" value="CG723_18315"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="APH" evidence="1">
        <location>
            <begin position="60"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN10494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="321" mass="34496" checksum="C15D42CB927EB3F1" modified="2018-04-25" version="1">MTDHEIDEPLGEAVDEAVGEAIDQAIGEASDEAIGEQLVRSLLEERYPDLAALELHQSVRGWDNQLWRLGDELVVRLPRTPRAPDLLRKEHRWLPLLAQRLPLPVPTPLRLAEPSALFPHPWTIAEWVPGEPADRSPISEGGESADTLARFLTALHQEAPADAPANTGRGVPLAAISHHFDEAVRSVAAHVPEGVRDVLDEAVAAPAWEGPPVWLHGDLHPANVVVSDGTLSGVVDFGELCAGDPAMDLAAGWLLLPSAAGFLDAYERADEAMIRRARGWAVLQALSLVAIGRAGDQGLPGGKPTWGRAGRLTLDRVLASR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JUG4</accession>
    <name>A0A2M9JUG4_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 10">Cell division protein FtsX</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CG723_14965</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">CB01635</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 10">Part of the ABC transporter FtsEX involved in cellular division.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 10">Belongs to the ABC-4 integral membrane protein family. FtsX subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000004">
        <property type="protein sequence ID" value="PJN10525.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN10525">
        <property type="protein sequence ID" value="PJN10525"/>
        <property type="gene ID" value="CG723_14965"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007049">
        <property type="term" value="P:cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003838">
        <property type="entry name" value="ABC3_permease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004513">
        <property type="entry name" value="ABC_transpt_FtsX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040690">
        <property type="entry name" value="FtsX_ECD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47755">
        <property type="entry name" value="PTHR47755"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02687">
        <property type="entry name" value="FtsX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18075">
        <property type="entry name" value="FtsX_ECD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF003097">
        <property type="entry name" value="FtsX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="10 14" id="KW-0132">Cell division</keyword>
    <keyword evidence="6 10" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9 10 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="179"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="232"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="275"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="domain" description="FtsX_ECD" evidence="13">
        <location>
            <begin position="56"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="domain" description="FtsX" evidence="12">
        <location>
            <begin position="208"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00021907"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR003097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF02687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF18075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="PJN10525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="305" mass="33397" checksum="C4C42F91116EC528" modified="2018-04-25" version="1">MRAQFVLSEIGVGLRRNLTMTFAVIVSVALSLALFGGSLLMRDQVSTMKGYWYDKVNVSIFLCNKGDAESDPKCAKGAVTAEQKQQIVSDLDKMPVVEKVSHESADQAYKHYKEQFGDSPLASSLTPDQLQESYRVKLKDPEKYQVVATAFDGRDGVQSVQDQKGILDNLFGLLNGMNWAALAVMALMLVVALMLIVNTVRVSAFSRRRETGIMRLVGASSFYIQMPFIMEAAVAGVIGGVVACGMLLVGRYFMIDHGLALSEKLNLINFIGWDAVLAKLPLVLAIGLLMPAIAAFFALRKYLKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JV46</accession>
    <name>A0A2M9JV46_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">TetR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CG723_16330</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000004">
        <property type="protein sequence ID" value="PJN10753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN10753">
        <property type="protein sequence ID" value="PJN10753"/>
        <property type="gene ID" value="CG723_16330"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041490">
        <property type="entry name" value="KstR2_TetR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17932">
        <property type="entry name" value="TetR_C_24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="5">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="4">
        <location>
            <begin position="18"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PJN10753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="197" mass="21053" checksum="738CAFF11ED675D3" modified="2018-04-25" version="1">MIDVAVRVFAKRGYHAASVDEIAELAGVSKPMVYLYLDSKEGLFLACLRRESDRLVAAFQGAACAGGEPEERLYAGLAAFFAFVAGHRDSWVVLHRQASELSAAIAAGVAEARRAVMAEVAGLVGDGIADSGRGALLDAEDADFVAHALVGAADSLTDWMERHPGRSPDSIALRLMNMVWVGMRHVLDGEVWTPRDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JVG6</accession>
    <name>A0A2M9JVG6_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Endoribonuclease YbeY</fullName>
            <ecNumber evidence="7">3.1.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">ybeY</name>
        <name evidence="9" type="ORF">CG723_17120</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CB01635</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="7">Binds 1 zinc ion.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the endoribonuclease YbeY family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="7"/>
    <dbReference type="EMBL" id="NNBL01000004">
        <property type="protein sequence ID" value="PJN10886.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN10886">
        <property type="protein sequence ID" value="PJN10886"/>
        <property type="gene ID" value="CG723_17120"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004521">
        <property type="term" value="F:endoribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00009">
        <property type="entry name" value="Endoribonucl_YbeY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023091">
        <property type="entry name" value="MetalPrtase_cat_dom_sf_prd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002036">
        <property type="entry name" value="YbeY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020549">
        <property type="entry name" value="YbeY_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02130">
        <property type="entry name" value="YbeY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00043">
        <property type="entry name" value="TIGR00043"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01306">
        <property type="entry name" value="UPF0054"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 7" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="5 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 7" id="KW-0540">Nuclease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="7" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="6 7" id="KW-0862">Zinc</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="67"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="119"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="123"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="129"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010875"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PJN10886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="165" mass="18107" checksum="3FB65F4FDEEF9C6C" modified="2018-04-25" version="1">MSIDVNNESGTEVDEQAILDIARYALARMRIHPLSELSVIVVDADAMEQLHVQWMDLPGPTDVMSFPMDELRPPSKDDEEPPQGLLGDIVLCPEVAKKQGEDADTQHSMDEELQLLTVHGVLHLLGYDHEEPDEKAEMFGLQAAIVDGWRGDKGLTGPSPAPTVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-06-02" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JVX8</accession>
    <name>A0A2M9JVX8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_08165</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN10978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN10978">
        <property type="protein sequence ID" value="PJN10978"/>
        <property type="gene ID" value="CG723_08165"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="55"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="73"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN10978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="90" mass="10219" checksum="4D49A2F73A10B370" modified="2018-04-25" version="1">MRLAIVAGAKRAGRPLPNARGRPSSTTRDLEIPMPYRKGQQVEYRDQQDELQRGEIRSAEGSGAQTRYAVQNEATLREDKVSEHQIEREL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JWI9</accession>
    <name>A0A2M9JWI9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Protein phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_10040</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN11265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN11265">
        <property type="protein sequence ID" value="PJN11265"/>
        <property type="gene ID" value="CG723_10040"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013656">
        <property type="entry name" value="PAS_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01590">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13581">
        <property type="entry name" value="HATPase_c_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08448">
        <property type="entry name" value="PAS_4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07228">
        <property type="entry name" value="SpoIIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00065">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00331">
        <property type="entry name" value="PP2C_SIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="SSF81606"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PAS" evidence="1">
        <location>
            <begin position="16"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN11265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="796" mass="84925" checksum="3670EA20E2E1B4DC" modified="2018-04-25" version="1">MATMHASCETGHQNPFDTTTAAMIVLDAQGRVTGWSPAARNLYGADTRDVLGRSESEVLRDVRARGDTLRGFGAAGAREDARTERRTVRRPDGALVETVLRIFPVEQDRGRPAWVVMAAASDRYQEWVTDQSMLSGLFTQAPVGLSVYGPDAHLNWANDVVQQVMGWRAGEWEGQANRVLYPHGTILSPPGYHETEEVLEEVLRTGEAVLDVHWRGPTPAACEYHRVYSCSYFRLQDDAGHPLGVCEASVDITDGYEAQARLALLSRASGIGTTLDVGKTAEEVAGLVVPDLADSVRIEVMESVLAGEEPPSAASGAPTGLRLMAKRTRSAPPVAQSDVLLGVIGSLPVTAHQRLLAVPLLLGGTTLGTVTLLRQPPRAPFTEEDRALAEELASRTAVCVDNARRYVREHTTALKLQRDLLPRGLPQPSGIELAHRYIPTTGPLGVGGDWYDVIPLSGARVGLVVGDVVGHGVDAAATMGRLRTSVRALAALDLPPDELLTRLDDLVGQTRVGIHGTPGDAGTDRALGATCLYAVYDPTSRTCAMASAGHLPPVATGRGTGTRQAEPLDLPTGPPLGIGGLPFESVEFEFAEGTVLALFTDGIVKARGRDVDEGVADLCGALDASAGSLEKACDEAVSLCAPGSAEDDAALLLVRVHAFPEDSTASWQFASDPAEVAGVRALVREKLEDWGLDEAVFVSELVVSELVTNAIRHGRPPVSLRLLRDIDRTLICEVSDGGHTSPHLRNAGDEDEGGRGLFLVAQLTDMWGTRYERQGKTIWAEIGLGQEVPLDLLLQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JWP5</accession>
    <name>A0A2M9JWP5_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF190 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_10165</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0166 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN11289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN11289">
        <property type="protein sequence ID" value="PJN11289"/>
        <property type="gene ID" value="CG723_10165"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003793">
        <property type="entry name" value="DUF190"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011322">
        <property type="entry name" value="N-reg_PII-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015867">
        <property type="entry name" value="N-reg_PII/ATP_PRibTrfase_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02641">
        <property type="entry name" value="DUF190"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54913">
        <property type="entry name" value="SSF54913"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF190" evidence="2">
        <location>
            <begin position="10"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN11289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="118" mass="13058" checksum="C00323D4799EFFDB" modified="2018-04-25" version="1">MTRLTGRALRLTVFVGENHTWRRKPLYSEIVHRAHKAGLAGASVFRGIEGFGASSLIHTSRLLSLSEDLPMAVVIVDTEERVRAFLPELDELVSQGLVVLDDCEVIRYVGRENGGTRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JWS6</accession>
    <name>A0A2M9JWS6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Amidase</fullName>
            <ecNumber evidence="2">3.5.1.4</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_10460</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.4" evidence="2"/>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN11343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN11343">
        <property type="protein sequence ID" value="PJN11343"/>
        <property type="gene ID" value="CG723_10460"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004040">
        <property type="term" value="F:amidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043864">
        <property type="term" value="F:indoleacetamide hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1300.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000120">
        <property type="entry name" value="Amidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020556">
        <property type="entry name" value="Amidase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023631">
        <property type="entry name" value="Amidase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036928">
        <property type="entry name" value="AS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11895">
        <property type="entry name" value="PTHR11895"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01425">
        <property type="entry name" value="Amidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75304">
        <property type="entry name" value="SSF75304"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00571">
        <property type="entry name" value="AMIDASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidase" evidence="1">
        <location>
            <begin position="26"/>
            <end position="450"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN11343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="478" mass="49851" checksum="1908E37BD3011F20" modified="2018-04-25" version="1">MASDRAAGLAATARALAEGDVSSRVLVEEALARIDATQPALNAFRTVRGEAALAEADAADRERAAGEGASGGSRPLLGVPLAVKDDMDVAGEPTAFGCPGDFPPKTEDAEAVRRLRAAGAIVIGKTNTCELGQWPFTEGPAFGDTRNPWNHGHTPGGSSGGSAAAVAAGIVPAALGSDGAGSIRIPAAWTHLVGIKPQRGRISTWPWAESFHGITVNGTLGRTVEDAALLLDAASGPHDGDLHCPPRIGAAQAARDEPGKLRIALSLRMPFTATPKRLDPVVRARVVALAERLAALGHDVEEADPRYGQIGLAFVPRATAGVADRLRDVPDPALLDPRTRESARMGRVLGGAPLRLARRAEASLQRRVGAVFDTYDVVLAPTTATPPPRIGAMASLGGWRTDRAMIAACPYAWPWNVLGWPGVNVPAGFTGDGLPVGAQLLGPANSEPQLISLAAQLESDQRWFEKWPENLQESRTGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JWU7</accession>
    <name>A0A2M9JWU7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Pirin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CG723_10535</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CB01635</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the pirin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN11354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN11354">
        <property type="protein sequence ID" value="PJN11354"/>
        <property type="gene ID" value="CG723_10535"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012093">
        <property type="entry name" value="Pirin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008778">
        <property type="entry name" value="Pirin_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003829">
        <property type="entry name" value="Pirin_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13903">
        <property type="entry name" value="PTHR13903"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02678">
        <property type="entry name" value="Pirin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05726">
        <property type="entry name" value="Pirin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006232">
        <property type="entry name" value="Pirin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pirin" evidence="4">
        <location>
            <begin position="42"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="domain" description="Pirin_C" evidence="5">
        <location>
            <begin position="193"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="299"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF05726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PJN11354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="321" mass="35140" checksum="8D1756242DBA0F26" modified="2018-04-25" version="1">MSNLDREAVPTMCGGRGFVVAEPVRELLSPRRVKLGESTEVRRLLPNLGRRMVGAWAFVDHYGPDDIADEPGMQVPPHPHMGLQTVSWLHEGEVLHRDSTGSLQTIRPRELGLMTSGRAISHSEESPRPHARFLHGAQLWVALPDSHRHTEPRFEHHADLPQVTAPGLSATLILGELDGAASPGTTYTPIVGADLSLTRGADLSVPLEPDFEYAVLSMSGEAHVDGVPVLPGSMLYLGCGRTELPLRAESDASLMLLGGEPFEEELIMWWNFIGRSQDDITQAREDWMSGSRFGEVKGYEGDPLAAPELPPVPLKPRGRVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JWW1</accession>
    <name>A0A2M9JWW1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PIG-L domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_10695</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN11383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN11383">
        <property type="protein sequence ID" value="PJN11383"/>
        <property type="gene ID" value="CG723_10695"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016137">
        <property type="term" value="P:glycoside metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10320">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003737">
        <property type="entry name" value="GlcNAc_PI_deacetylase-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024078">
        <property type="entry name" value="LmbE-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12993">
        <property type="entry name" value="PTHR12993"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02585">
        <property type="entry name" value="PIG-L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102588">
        <property type="entry name" value="SSF102588"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN11383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="252" mass="27567" checksum="154F43B84271A7B7" modified="2018-04-25" version="1">MTEPKIQNAARDQLQPMPEDWQRALAVVAHPDDLEYGCSAAIAAWTDGGREVAYVLATRGEAGIDTLEPAKCAPLREQEQRASAAVVGVDTVEFLDHKDGVVEYGTVLRRDIAAAIRRHRPELVITLNHRDTWGGVAWNTPDHVAVGRATLDAAADAGNRWIFPELIEQGLEPWNGVRWVAVAGSSSPTHAVDATPGIERAVHSLLEHRTYIEVLTDEDPETYCRSFLTGNVQAVAERFGGTPAVPFELFSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JX45</accession>
    <name>A0A2M9JX45_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Hydroxyacid dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CG723_11175</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CB01635</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN11460.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN11460">
        <property type="protein sequence ID" value="PJN11460"/>
        <property type="gene ID" value="CG723_11175"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006139">
        <property type="entry name" value="D-isomer_2_OHA_DH_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029753">
        <property type="entry name" value="D-isomer_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029752">
        <property type="entry name" value="D-isomer_DH_CS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006140">
        <property type="entry name" value="D-isomer_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00389">
        <property type="entry name" value="2-Hacid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02826">
        <property type="entry name" value="2-Hacid_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00065">
        <property type="entry name" value="D_2_HYDROXYACID_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00671">
        <property type="entry name" value="D_2_HYDROXYACID_DH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="2-Hacid_dh" evidence="4">
        <location>
            <begin position="37"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="domain" description="2-Hacid_dh_C" evidence="5">
        <location>
            <begin position="112"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005854"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PJN11460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="317" mass="32622" checksum="9E105BC2DF0FFDD0" modified="2018-04-25" version="1">MPTTLVTTPTFARYSARPWQILEEAGAGPLRPSEDAALPAAELLKYAACADALVVGMDPITAEVMDAAPGLKVIAKHGVGVDTIDVAAARARGIPVVCAPGSNSRAVAEYTFGLLLSATRSLAASHTAVEAGGWPKLFGPELHGKTLGIVGFGRIGRLLAGYARAFGMELLAHDPYVQDSDVRAHGAEPAALEALLARADAVSLHTPPDPSGTPLLDRARLAAMKEGAVLVNAARGSLVDERALADLLGSGHLGAAALDAFSTEPLPADHPLRAAPRTLLTSHMAACTPEANQAMGAMVAEDVVRVLAGKEPQHQAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JX48</accession>
    <name>A0A2M9JX48_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_10370</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN11327.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN11327">
        <property type="protein sequence ID" value="PJN11327"/>
        <property type="gene ID" value="CG723_10370"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041581">
        <property type="entry name" value="Glyoxalase_6"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18029">
        <property type="entry name" value="Glyoxalase_6"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glyoxalase_6" evidence="1">
        <location>
            <begin position="15"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="domain" description="Glyoxalase_6" evidence="1">
        <location>
            <begin position="135"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF18029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN11327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="243" mass="26503" checksum="F6CEAE3771ED280B" modified="2018-04-25" version="1">MVIRWVYAFIDRPEAHFGAACDFWTRVTGTHLSAPRGDHDEFATLLPDGSADPHLKAQAVNGPGGAHLDFAVDDLARTTGLAHRLGATPVHTEDGLEVLRSPGGQLFCLVPWSGEHRRPAPVTAPDGTTSRLDQVCIDLAPAVYEAEIDFWTKFTAWTSSPGTLPEFHRIRPPTELPVQILLQRLTAARPTAAHLDLACTNTESTRAWHESLGAKLVSKGAHWLVLQDPSATRYCLTSRPPTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JXL1</accession>
    <name>A0A2M9JXL1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alpha-ketoglutarate-dependent dioxygenase AlkB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_12070</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN11616.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN11616">
        <property type="protein sequence ID" value="PJN11616"/>
        <property type="gene ID" value="CG723_12070"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006307">
        <property type="term" value="P:DNA dealkylation involved in DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035552">
        <property type="term" value="P:oxidative single-stranded DNA demethylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.590">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027450">
        <property type="entry name" value="AlkB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037151">
        <property type="entry name" value="AlkB-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032854">
        <property type="entry name" value="ALKBH3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31212">
        <property type="entry name" value="PTHR31212"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13532">
        <property type="entry name" value="2OG-FeII_Oxy_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="1">
        <location>
            <begin position="109"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN11616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="209" mass="23030" checksum="124B423AE01A107D" modified="2018-04-25" version="1">MATHQLQGSLFDQSDDVRLRPLDGVRRTALGDGAWIDLLPGWLTGADALFEQLATDVPWKAERRQMYERLVDVPRLLAFYGAGEPLPHPVLDEARQTLSAHYATELGEPFTTAGLCHYRDGRDSVAWHGDRIGRGAREDTMVAILSVGAPRDLLLRPRAGGDVVRRPLGHGDLIVMGGSCQRTWEHAIPKTTRAAGGRISIQFRPHGVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JXN4</accession>
    <name>A0A2M9JXN4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Acyl-CoA dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CG723_12240</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CB01635</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN11643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN11643">
        <property type="protein sequence ID" value="PJN11643"/>
        <property type="gene ID" value="CG723_12240"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003995">
        <property type="term" value="F:acyl-CoA dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006089">
        <property type="entry name" value="Acyl-CoA_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="SSF47203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="SSF56645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00073">
        <property type="entry name" value="ACYL_COA_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0274">FAD</keyword>
    <keyword evidence="3 5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA_dh_N" evidence="8">
        <location>
            <begin position="7"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_M" evidence="7">
        <location>
            <begin position="123"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_1" evidence="6">
        <location>
            <begin position="235"/>
            <end position="383"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PJN11643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="385" mass="42086" checksum="FA318B84627AE983" modified="2018-04-25" version="1">MKRTVYNEDHEAFRSVVRDFIAKEVSPRYEEWERDNRVPRELFHQLGELGVMGFGIPEEYGGPGETSYKYQTVITEECARVAVSFGHYTVTTGIVLPYLLNIADEEQKKRWLPGIASGAITLCIAMTEPGTGSDLAGIRTRAELSDDGTHYVLNGAKTFITGALNSELCVVVARTSPPTAEDRRFGLTLLVVPTDSEGFAYGRKLDKIGLRASDTSELSFTDVKVPVENVLGEVGKGFSYLGNNLARERLSIGVGGVATASAAIQFAKAYVQERQVFGKPVAAFQNTKFVLAECAAEVEAAQAMVDKGIELDDRHELSPADAAKIKLFCTEVAARVIDKCLQLHGGYGYMLEYPIARLYADTRVSRIYGGTSEVMKTIIAKDLGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JXQ3</accession>
    <name>A0A2M9JXQ3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Alkyl/aryl-sulfatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CG723_12285</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CB01635</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the metallo-beta-lactamase superfamily. Type III sulfatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN11651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN11651">
        <property type="protein sequence ID" value="PJN11651"/>
        <property type="gene ID" value="CG723_12285"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018741">
        <property type="term" value="F:alkyl sulfatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018909">
        <property type="term" value="P:dodecyl sulfate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07710">
        <property type="entry name" value="arylsulfatase_Sdsa1-like_MBL-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038536">
        <property type="entry name" value="Alkyl/aryl-sulf_dimr_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029229">
        <property type="entry name" value="Alkyl_sulf_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029228">
        <property type="entry name" value="Alkyl_sulf_dimr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044097">
        <property type="entry name" value="Bds1/SdsA1_MBL-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036527">
        <property type="entry name" value="SCP2_sterol-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14864">
        <property type="entry name" value="Alkyl_sulf_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14863">
        <property type="entry name" value="Alkyl_sulf_dimr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55718">
        <property type="entry name" value="SSF55718"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Lactamase_B" evidence="5">
        <location>
            <begin position="88"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00033751"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PJN11651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="622" mass="67955" checksum="385CBF4722867B60" modified="2018-04-25" version="1">MPSTPEPDWEDTTDQVNATRGLVDKLEPCVVRNEAGRVVWDNDRWDFLSKDDCPDTVHPSLWRQSRINTAQGLFEVVPGVFQVRGLDVSNMTIIEGDAGVVVVDPLTSKEVAAEALGLYARNRGERPVKAVIYTHSHGDHFGGVLGVTTTQAVAAGDCAVVAPDAFMHHAVSENVFAGPAMLRRAVYMYGRSLPVGADGSVGFGLGQALSTGTVGLIPPTESITGTGQELVLDGVRLVFQLTPDTEAPSEMNFYLPDHRVLLIAENVNHSLHNVLTLRGAQVRDAHAWASYITESIQLFDEAEVLIGSHNWPTWGEDEVIRVLTEQRDAYAYLHDQTVRLMNQGLTGPEIAEEIQSFPGELGKAWSVRGYYGSISHNVKAVYQRYMGWYDGNPAHLWQHPPVEQAKRYVAAIGGTDATVASAREAVASGDLRWAAELLNHVLFAEPEHTAARELQIATYERLGFAQENGTWRNIYLTGAKELREAGQERRGTGAPGKESVEMLAALTTAQIFDSMAVRLDGPRAAAHRLLLRWEFTDTDEVWTLLVGNGVLTPIRGDAPGAESPQLTLRLERATLDQVLAQRTSFPEAIGSGAVTVAGDVTVLSTFYGLLEKPRRNFPIVLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JYA2</accession>
    <name>A0A2M9JYA2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Cytochrome d ubiquinol oxidase subunit II</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">cydB</name>
        <name evidence="8" type="ORF">CG723_13400</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CB01635</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytochrome ubiquinol oxidase subunit 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN11831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN11831">
        <property type="protein sequence ID" value="PJN11831"/>
        <property type="gene ID" value="CG723_13400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003317">
        <property type="entry name" value="Cyt-d_oxidase_su2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43141">
        <property type="entry name" value="PTHR43141"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02322">
        <property type="entry name" value="Cyt_bd_oxida_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000267">
        <property type="entry name" value="Cyt_oxidse_sub2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00203">
        <property type="entry name" value="cydB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="74"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="120"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="162"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="197"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="222"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="248"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="297"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PJN11831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="333" mass="36967" checksum="8FF1F8683D09E287" modified="2018-04-25" version="1">MHLHDLWFILIAVLWIGYFFLEGFDFGVGVLTKSLARNSTERRVLINTIGPVWDGNEVWLITAAGATFAAFPDWYATMFSGFYIPLLIILFCLIVRGVAFEYRAKQSGARWQHNWEEATFWTSLLPPFLWGVIFANMVRGLAIDADKSYVGGLGDLFNGYTILGGFMTLVLFVCHGAVFTALKTLGDIRDRARTQATQLGAPAVLLLLAFLIWTQVESGNGRSLGVMIVAFLALIGALVMTRLGRDGWAFTLSGLTVVAAFAMLFLALYPDVMPSTLNPDWSLTVSNASSSSYTLKVMTIVAAVFTPIVLIYQIWTYWVFRRRIGVQHIPAGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-06-02" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JYA7</accession>
    <name>A0A2M9JYA7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Esterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_13635</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN11866.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN11866">
        <property type="protein sequence ID" value="PJN11866"/>
        <property type="gene ID" value="CG723_13635"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013094">
        <property type="entry name" value="AB_hydrolase_3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07859">
        <property type="entry name" value="Abhydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Abhydrolase_3" evidence="2">
        <location>
            <begin position="107"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="31"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN11866.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="344" mass="36871" checksum="69F1F9448CE1408C" modified="2018-04-25" version="1">MSVRRARSESESGRAPAPTAVPPFDPELSFVLADLDKESRKPLTPENLAARQKRDATARPRPTVEDLRADGRFEVTELRIPGPPGGPEVTLVSARPSGLVGPLPLLYYMHGGAMVMGNAWSVLPRILREWALPLDMAVISVEYRLAPRAQHPGPLEDCYAGLAWAAEHAAELGVDPDRIIIGGKSAGGGLAAALALLSRDRGGPETLGQLLLCPMLDDRGSTFSSQQMSGLGLWDLTSNATAWQALLGDLCGAEDLPPYAAPSRATDLSQLPPAYLDVGSAEMFRDEGVAYANAIWQAGGQAELHVWPGAYHGFDSLAPKAALSRDARNARTCWLQRLLADRRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JYF3</accession>
    <name>A0A2M9JYF3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_13830</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN11900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN11900">
        <property type="protein sequence ID" value="PJN11900"/>
        <property type="gene ID" value="CG723_13830"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="2">
        <location>
            <begin position="13"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN11900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="212" mass="23047" checksum="F871F277BF8506BF" modified="2018-04-25" version="1">MTAPQGAAADASSILIVDDMEENLVALEAVLGSLARVVRARSGEAALKAMLRQDFAVALIDVMMPGMNGFETAANIKGLHQTKDVPIILLTGAAVDPNYAYRGYTVGAADFLIKPFDPWLLRTKVNVFLDLHRKNRQLAEQAEQLTRLLAVDVPTHPPEEQHRLADVERQLAQVQRLLREGDGSDAPEAAGLADRIAVLEEAVGRLLEPPEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JYX6</accession>
    <name>A0A2M9JYX6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Short-chain dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_14870</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN12074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN12074">
        <property type="protein sequence ID" value="PJN12074"/>
        <property type="gene ID" value="CG723_14870"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="263"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN12074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="287" mass="29424" checksum="0B1AD686CB074FDC" modified="2018-04-25" version="1">MASPGSDPIVAVVTGASRGAGRGIAEALGSQGATVYVTGRSRSASDSPYGGTVTETAALVDAAGGTGVPAVVDHGDDQAVQNLFAAIGQEHGRLDILVNNAANFAGAPVLGGFWEMPLERADLLTVGLRSHYVASYYAAPLLIANGRGLIVNTGHYGAVSYHQGPAYGAQKAGADKMAADMAKELRPYNVAAVSIWMGGLDTERARAYIASLPSQDRPTAKRESPQFTGRVIAALYSSDELAALSGRALIGAELGSLLSVTDMDGSTPRSMRHVLGGPPEPHPSLLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JZ18</accession>
    <name>A0A2M9JZ18_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Amino acid permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CG723_09325</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CB01635</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the amino acid-polyamine-organocation (APC) superfamily. Amino acid transporter (AAT) (TC 2.A.3.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN12110.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN12110">
        <property type="protein sequence ID" value="PJN12110"/>
        <property type="gene ID" value="CG723_09325"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006865">
        <property type="term" value="P:amino acid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004841">
        <property type="entry name" value="AA-permease/SLC12A_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004840">
        <property type="entry name" value="Amoino_acid_permease_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00324">
        <property type="entry name" value="AA_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00218">
        <property type="entry name" value="AMINO_ACID_PERMEASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="40"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="87"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="118"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="151"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="191"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="233"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="273"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="327"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="353"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="400"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="domain" description="AA_permease" evidence="8">
        <location>
            <begin position="10"/>
            <end position="438"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PJN12110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="465" mass="48900" checksum="0F031281BACC645E" modified="2018-04-25" version="1">MKRSLTGRQLSMMGLGGAIGTGLFLGSGLAISAAGPAAVIAYVLCALIALVIGWALAEMTAVHPATGSFGTIGRHYLGPLAGFVIRWTYWTIQVIAIGGEVIAGGIYVRFWWPELPLWAPVVAFSLLLLAANALTVGVFGRLEYWFSTIKITAIGVFVLLGCAYVFLGLPGHEAAGTSNLSGPGGLLPHGLSGLGTAFVFVIFSYIGTEIIAVTAAESENPVRDIPRAARRMVVRLALFYVLAMAVVVTVVPWSRTAAGGDVTASPFVQLFDVAGIPAAAGIMNFVVLTAALSSANANTYLATRMIHSLAVDRHAPRMFARVGRSGVPHRALAVSGLGLGAAAILSVHSEDTAYVLLFGISVFGALVVWILILATHLMFRRHRVRHDLPSSPARLRGAPFTTVAAALALAAILVSTAFIEGLEDSWKAGLPFFALLVVVYRFGARRHETAEPLPDSTLPPEGPTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JZE6</accession>
    <name>A0A2M9JZE6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_04105</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000002">
        <property type="protein sequence ID" value="PJN12255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN12255">
        <property type="protein sequence ID" value="PJN12255"/>
        <property type="gene ID" value="CG723_04105"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="32"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN12255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="185" mass="19756" checksum="72BDEEFA9E035D24" modified="2018-04-25" version="1">MGRDTRAGSRGRAAAPASQDTVVRDRRWAADLRAAVFCALTLFCLILVIDTANGTLSAARVGLWAGLSALLHAVLHPPLVSAGPGWLAVRGVWGTRRVCTDLLTSVRHSDGVTPRLVLRDALGGRVELDPKVLTDNPVVWHRLETGARRARANGLLRCGTPVVDRLAARIDGDAARAVFEASELD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JZS9</accession>
    <name>A0A2M9JZS9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Peroxiredoxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CG723_04610</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000002">
        <property type="protein sequence ID" value="PJN12340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN12340">
        <property type="protein sequence ID" value="PJN12340"/>
        <property type="gene ID" value="CG723_04610"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004601">
        <property type="term" value="F:peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000866">
        <property type="entry name" value="AhpC/TSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024706">
        <property type="entry name" value="Peroxiredoxin_AhpC-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00578">
        <property type="entry name" value="AhpC-TSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000239">
        <property type="entry name" value="AHPC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="1" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="4">
        <location>
            <begin position="3"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="active site" description="Cysteine sulfenic acid (-SOH) intermediate" evidence="3">
        <location>
            <position position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000239-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PJN12340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="152" mass="17024" checksum="1C67268E4A802E95" modified="2018-04-25" version="1">MTIEVGTKAPDFELKTQHGETVRLSDFRGEKNVVLLFYPFAFTGVCTGELCALRDELPKFVNDDVQLLAVSNDSPFSLRVFAEQEGLEYPLLSDFWPHGEASRAYGVFDEEKGCAVRGTFIIDKEGVVRWTVVNGLPDARDLNEYVKAIDTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JZZ7</accession>
    <name>A0A2M9JZZ7_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">M20_dimer domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_05030</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000002">
        <property type="protein sequence ID" value="PJN12410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN12410">
        <property type="protein sequence ID" value="PJN12410"/>
        <property type="gene ID" value="CG723_05030"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001261">
        <property type="entry name" value="ArgE/DapE_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036264">
        <property type="entry name" value="Bact_exopeptidase_dim_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002933">
        <property type="entry name" value="Peptidase_M20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011650">
        <property type="entry name" value="Peptidase_M20_dimer"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07687">
        <property type="entry name" value="M20_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01546">
        <property type="entry name" value="Peptidase_M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55031">
        <property type="entry name" value="SSF55031"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00758">
        <property type="entry name" value="ARGE_DAPE_CPG2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="M20_dimer" evidence="2">
        <location>
            <begin position="199"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN12410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="441" mass="47948" checksum="231051DAC5A2F2F3" modified="2018-04-25" version="1">MNTPSALTPASEEAQAEVVGLCAELIRFDTSNPTSDERACADWVVDRLAEAGIDSTLVESAPGRANVIARIPGADSTRGALLVHGHLDVVPADAAEWQVPPFSGEIRDGYLWGRGAIDMKDTVAVMLATARHFARTGTRPSREIVLAFLADEEAGGKFGAHWLVEHHPELFAGVTEAIGEGGGFSYALDDTQRLYPIENAQRGMAWMELTATGRAGHGSSPNDENAVTDLSESLTRIGRHTFPIRLIEPVRALLTKAAELKGVKIDFEADDLDAELAELGPVADFMQVVLRNSANPTMFTAGYQTNVIPGKATARVDGRFLPGHEQELVDTIDELLLPSVRREWVNHDIAMETTFDGPLVDAMCEAVRAEDPDGHPVPYCNPGGTDAKAFTKLDIRCFGFKGLKLPHDLDYGRLFHGVDERVPLEGLRFGVRVMTRLWQSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K001</accession>
    <name>A0A2M9K001_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CG723_04585</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CB01635</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000002">
        <property type="protein sequence ID" value="PJN12337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN12337">
        <property type="protein sequence ID" value="PJN12337"/>
        <property type="gene ID" value="CG723_04585"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004638">
        <property type="entry name" value="EmrB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00711">
        <property type="entry name" value="efflux_EmrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="31"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="69"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="100"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="128"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="157"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="185"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="219"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="251"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="289"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="324"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="352"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="381"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="496"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="7">
        <location>
            <begin position="33"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PJN12337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="536" mass="54978" checksum="12BE29371A36BC08" modified="2018-04-25" version="1">MTSQTTVDKADKAPEPVSVPAPAKGLRGHPWLTLFSVAIGVMMVALDGTIVAIANPAIQKDLGASFADVQWITNGYFLALAVTLITAGKLGDRFGHRQTFLIGVIGFAAASGAIGLSDSIALVVTFRVLQGLFGALLMPAALGLLRATFPAEKLNMAIGIWGMVIGASTAGGPILGGLLVQHVSWQSVFFINVPVGVIALVLGLLILKDHRAENAPRSFDVLGIVLLSAAMFSLVWALIKAPAWGWGDGLTWTFLAASVLCFALFAIWETRVKEPLIPLALFRSVPLSAGVVLMVLMAIAFMGGLFFVTFYLQNVHGMSPVDSGLHLLPLTGMMIVGSPLAGAMITKVGPRIPLAGGMLLTAVAMYGMSTLESGTGSGAMSLWFALLGLGLAPVMVGATEVIVGNAPMELSGVAGGLQQAAMQIGGSLGTAVLGAVMASKVDNDLAGNWTDAKLPPLTPAQLDQASEAVQVGVGPVPKGTPAELAEKITSVAHDTFISGMSLACLVAAGVAVVAIFVAFLTKRGTNAEAGAGAAHI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-09-29" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K020</accession>
    <name>A0A2M9K020_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CG723_05460</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CB01635</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000002">
        <property type="protein sequence ID" value="PJN12483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN12483">
        <property type="protein sequence ID" value="PJN12483"/>
        <property type="gene ID" value="CG723_05460"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="50"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="101"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="163"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="189"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="253"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="284"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="313"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="339"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="381"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="404"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="7">
        <location>
            <begin position="30"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PJN12483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="434" mass="44812" checksum="9516F47BD2612A94" modified="2018-04-25" version="1">MYVADSRAAASAEPAARPPAGRRGTAVAPTVLALGSVSLITDVSSEMVTAVLPLYLVAGLGLSPLGFGLLDGVYNGFSALVRLVGGHFADRGGGRHKTVALFGYGLSALCKPLLLLAATLPTIGMVLAADRTGKGLRTAPRDALISLSSTPATRGRAFGVHRAMDTTGALLGPLAAFLILRATTDGYDAVFTVSFCVAALGVLVLLLFVPRRHEAAQETANKTAKGSHPAPPRPTFRSALALLRRREVRRTTVCALLLGLATVSDSFVYLLLQRRLGVPDQWFALLPLGTAAAFLLLAAPLGRLADRVGSWRVFLCGHAALLAAYGLLLSPWHGSALPYAVLALHGCFYAATDGVLMAAASTAIPQELRSSGLAVVQTGQALARFVCSIGFGAAWTAWGDRTALGAATVALSAGAAVAYAFRPEAPTPAEVVPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K044</accession>
    <name>A0A2M9K044_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">TPR_5 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_05560</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000002">
        <property type="protein sequence ID" value="PJN12501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN12501">
        <property type="protein sequence ID" value="PJN12501"/>
        <property type="gene ID" value="CG723_05560"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041656">
        <property type="entry name" value="TPR_5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12688">
        <property type="entry name" value="TPR_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TPR_5" evidence="1">
        <location>
            <begin position="47"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN12501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="170" mass="18312" checksum="48C66393BD16EC27" modified="2018-04-25" version="1">MSSEDWDARLTAAWASIDDYDESTAGDFRAAIDDLVAELPDGSPVGPFERGSAFDSTGHSDRAVPLYQEALKLGLSGYRGRRAKIQLSSSLRNIGRPEEGVALLTPELDAPSDELDDAVRATLALCLSSLGRDREGLSLALGALAPHLPRYQRSMANYARLLVEAEPEPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K089</accession>
    <name>A0A2M9K089_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">GntR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CG723_05750</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000002">
        <property type="protein sequence ID" value="PJN12536.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN12536">
        <property type="protein sequence ID" value="PJN12536"/>
        <property type="gene ID" value="CG723_05750"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07377">
        <property type="entry name" value="WHTH_GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.530">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011711">
        <property type="entry name" value="GntR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008920">
        <property type="entry name" value="TF_FadR/GntR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07729">
        <property type="entry name" value="FCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
        <property type="entry name" value="GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00895">
        <property type="entry name" value="FCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00345">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48008">
        <property type="entry name" value="SSF48008"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50949">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH gntR-type" evidence="4">
        <location>
            <begin position="7"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PJN12536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="207" mass="22756" checksum="F3C341AFC646BE03" modified="2018-04-25" version="1">MTAPVVHSLREQIREHIVEGIVSGRWKPGERIVERRIATELEVSQTPVREALRELESLRLIESAPNKGVRVRNLTAADLEESYPVRAGLEAIAAELAAGKLAEDCSALEPHVAALYRADQEADGTGQVRHTVAFHRELVRAAGNSVLLHTWEGLGIEVFTALSIRWLGTVQQSYAEEHEALVAAFRRRDPAIAELVKAHVLGCAPRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K0B8</accession>
    <name>A0A2M9K0B8_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">3-methyl-2-oxobutanoate hydroxymethyltransferase</fullName>
            <ecNumber evidence="5">2.1.2.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Ketopantoate hydroxymethyltransferase</fullName>
            <shortName evidence="5">KPHMT</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5 10" type="primary">panB</name>
        <name evidence="10" type="ORF">CG723_05360</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CB01635</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + 3-methyl-2-oxobutanoate + H2O = (6S)-5,6,7,8-tetrahydrofolate + 2-dehydropantoate</text>
            <dbReference type="Rhea" id="RHEA:11824"/>
            <dbReference type="ChEBI" id="CHEBI:11561"/>
            <dbReference type="ChEBI" id="CHEBI:11851"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15636"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="EC" id="2.1.2.11"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5 8">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="5 8">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="5">Cofactor biosynthesis; (R)-pantothenate biosynthesis; (R)-pantoate from 3-methyl-2-oxobutanoate: step 1/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2 5">Homodecamer; pentamer of dimers.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the PanB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.2.11" evidence="5"/>
    <dbReference type="EMBL" id="NNBL01000002">
        <property type="protein sequence ID" value="PJN12467.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN12467">
        <property type="protein sequence ID" value="PJN12467"/>
        <property type="gene ID" value="CG723_05360"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00028">
        <property type="reaction ID" value="UER00003"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003864">
        <property type="term" value="F:3-methyl-2-oxobutanoate hydroxymethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015940">
        <property type="term" value="P:pantothenate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06557">
        <property type="entry name" value="KPHMT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00156">
        <property type="entry name" value="PanB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003700">
        <property type="entry name" value="Pantoate_hydroxy_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_Kinase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040442">
        <property type="entry name" value="Pyrv_Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20881">
        <property type="entry name" value="PTHR20881"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02548">
        <property type="entry name" value="Pantoate_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000388">
        <property type="entry name" value="Pantoate_hydroxy_MeTrfase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="SSF51621"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00222">
        <property type="entry name" value="panB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3 5" id="KW-0566">Pantothenate biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5 10" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Alpha-ketoisovalerate binding" evidence="5 7">
        <location>
            <begin position="71"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="5 6">
        <location>
            <position position="208"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5 8">
        <location>
            <position position="71"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5 7 8">
        <location>
            <position position="110"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5 7">
        <location>
            <position position="140"/>
        </location>
        <ligand>
            <name>3-methyl-2-oxobutanoate</name>
            <dbReference type="ChEBI" id="CHEBI:11851"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5 8">
        <location>
            <position position="142"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000388-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000388-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000388-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PJN12467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="291" mass="30727" checksum="09D8A6F27A7DD38F" modified="2018-04-25" version="1">MTQLSAAQNNPDSSNSGSKALYGGKSNRRITVRDITLAKERGEKWPMLTAYDAMTASVFDEAGIPVMLVGDSAGNCHLGYETTVPVTLDEMTMLSAAVVRGTKRALIVGDLPFGSYQEGPVQALRSATRLVKEAGVGAVKLEGGERSLAQTELLVQSGIPVMSHLGLTPQSVNTMGYRVQGRGDEDAHRLLRDAKAAQDAGAFAVVLELVPAELAAEVTRSLNIPTVGIGAGAECDAQVLVWTDMLGLTGGKMPRFVKQYADLRGVMGEAAKAFAQDVVGGTFPQEEHSVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K0H5</accession>
    <name>A0A2M9K0H5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Carbonic anhydrase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_06195</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the reversible hydration of carbon dioxide to form bicarbonate.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the beta-class carbonic anhydrase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000002">
        <property type="protein sequence ID" value="PJN12619.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN12619">
        <property type="protein sequence ID" value="PJN12619"/>
        <property type="gene ID" value="CG723_06195"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004089">
        <property type="term" value="F:carbonate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001765">
        <property type="entry name" value="Carbonic_anhydrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036874">
        <property type="entry name" value="Carbonic_anhydrase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43175">
        <property type="entry name" value="PTHR43175"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00484">
        <property type="entry name" value="Pro_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00947">
        <property type="entry name" value="Pro_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53056">
        <property type="entry name" value="SSF53056"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00024993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN12619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="182" mass="19888" checksum="F0FE5615DDD12143" modified="2018-04-25" version="1">MTTSASLPAESESAIPVDGTVTDRLVEANQRYAAAFTDPGMDARPVLKVAVVACMDARLDLHDALGLELGDCHTIRNAGGVVTDDVIRSLTISQRALGTRSVVLIHHTGCGLESLTEEFRHELEMEVGQRPAWAVEAFRDVDQDVRQSMQRVRTSPFLVDTDNVRGFVFDVKTGLLREIDPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K0W5</accession>
    <name>A0A2M9K0W5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Zn-dependent hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_07155</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000002">
        <property type="protein sequence ID" value="PJN12781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN12781">
        <property type="protein sequence ID" value="PJN12781"/>
        <property type="gene ID" value="CG723_07155"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lactamase_B" evidence="1">
        <location>
            <begin position="32"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN12781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="218" mass="23473" checksum="EE72049A3378DB6F" modified="2018-04-25" version="1">MTYSGAVKVGGPADVHELQNLMISKVAVGAMNNNAYLLRCRATGEQLLIDAAADPETLLTLIGDDGIASVVTTHQHGDHWQALARVVEVTSPRTYAGRYDAEGIPVPTDVLVEDGDTINVGRVSLTARHLVGHTPGSIALVYDDPHGHPHVFTGDCLFPGGVGNTWKDPKAFASLIDDVESKIFGPLPDETWVYPGHGNDTTLGAERPHLPEWRERGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K194</accession>
    <name>A0A2M9K194_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_07755</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000002">
        <property type="protein sequence ID" value="PJN12894.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN12894">
        <property type="protein sequence ID" value="PJN12894"/>
        <property type="gene ID" value="CG723_07755"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014780114" evidence="1">
        <location>
            <begin position="20"/>
            <end position="375"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN12894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="375" mass="39928" checksum="36D9D83CA7896C62" modified="2018-04-25" version="1">MRTARATAAAVTAVIGAGAAAIAAGRFASDAALKAPAGRPLPTEPRLTVHATAAGQITLTRDLASLRPGTYGLSGDGFHAVVGPVLESAPHAADAVVRRLERVTHGSLEPGAKAWLTPQVHIGDPKAALGLDHADIDIPGELGGLPAWFVPGARDTWVITVHGLGTTREHPMVLMDFLHRHRFPVLDLAYRGDLGAPRSPDGLGHLGETEWRDLDAAIRYAVRYGAQRVIVHGWSTGAAMALHAAAHSALRDRISGLVLDSPVLAWDVTLRALAEARRVPRPLLPLAVRAAQGRTGLHGDRLDTAAHPEALKVPTLLMHGPDDEIAPWGLSRELAARRPDLVSLHTVDNAPHGAMWNADPQTYEETLRRFLTPLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K1U3</accession>
    <name>A0A2M9K1U3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_00370</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000001">
        <property type="protein sequence ID" value="PJN13096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN13096">
        <property type="protein sequence ID" value="PJN13096"/>
        <property type="gene ID" value="CG723_00370"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025447">
        <property type="entry name" value="DUF4192"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13830">
        <property type="entry name" value="DUF4192"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="364"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="364"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="424"/>
            <end position="446"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN13096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="482" mass="51700" checksum="8D159BDE5866D2B5" modified="2018-04-25" version="1">MTNHSEAAGAPGTEQITLRNPSELAEALPYLLGFRPEDSIVLVALHRGRFGGRVRLGIPERPGDWPSVADEMAKCLISGCERKDGTPDGIVAFLCRDPKATETGRQIMERLHPLAQMLRLACGRLDVPVVETLCIADDHFWSYSCPVAECCPPDGTPLAASGTSVTAAAMTYAGIQVRRPLREMRARLTPWQTAAVPDQERALDAAAMALVPRILAGVPRVEVADETLDLARRVWSRFGHLPTGGDTLEADLKDDEQLAHDEAARLILGLQDRLTRDHAAEWMEGDEAPLVLRLWRALARRCVGPYGEHAAAPLTLAGWVAWSLGDRVEAGEALDMALAADPRYVFARLLMEACSADLDPEPVRRSLRKTRDERNVTPSGAGSEEDSDGAGAGVAVGARPVAGVNAEGAAGRKGAGSSGRPSAEDSREPAEDRVTRALEAALRRRGSRRAGAGKGPAQAGAHAPRRPQGRRRVGRQGTRRDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K1Z1</accession>
    <name>A0A2M9K1Z1_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Histidine kinase</fullName>
            <ecNumber evidence="3">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CG723_00595</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CB01635</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="3"/>
    <dbReference type="EMBL" id="NNBL01000001">
        <property type="protein sequence ID" value="PJN13135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN13135">
        <property type="protein sequence ID" value="PJN13135"/>
        <property type="gene ID" value="CG723_00595"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00672">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00304">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 11" id="KW-0418">Kinase</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="38"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="117"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="10">
        <location>
            <begin position="141"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="9">
        <location>
            <begin position="202"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PJN13135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="414" mass="44881" checksum="3AC25D0AD106477F" modified="2018-04-25" version="1">MASSPAPPAAPPKPTWDPRKAEPPYPWLRPTIRIRLTLLYGGMFLIAGILLLSIIYLLAAQALNVGSDLPFTVTGGTVSSGTCRNFTGLPDHPTTSQLNSALNECVNEMRQHALDNLLSRSLLALLGLAVIAFAFGYAMAGRVLSPLGRITRTARRVAGTDLSRRIELDGPDDELKELSDTFDDMLDRLERAFTAQQRFVGNASHELRTPLAINRTLLEVHLSDPGAPVELQQLGKTLLATNERSEQLVEGLLLLARSDNQIVERKPVDLAEVASQAIDQTRSEADAKGVEIRGERKEAVVQGNGVLLERIALNLVQNAVRYNVPEGGWVEVTTEAQHGQAVLVVSNTGPVVPAYEIDNLFEPFRRLRTERTGSDKGVGLGLSIARSVARAHGGRIIAEPREGGGLVMRVTLPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K295</accession>
    <name>A0A2M9K295_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_00660</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000001">
        <property type="protein sequence ID" value="PJN13147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN13147">
        <property type="protein sequence ID" value="PJN13147"/>
        <property type="gene ID" value="CG723_00660"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016566">
        <property type="entry name" value="UCP010219"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11361">
        <property type="entry name" value="DUF3159"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF010219">
        <property type="entry name" value="UCP010219"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="53"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="81"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="110"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="159"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="185"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN13147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="246" mass="26743" checksum="CA6E60CFDD887DC9" modified="2018-04-25" version="1">MTSLDKPTADQDADSKAVTEAALFEAFGGVRGMVETVVPGLLFVTIFTINKDLHMSAIAALAVSLVLVVVRLVMKGTVKHAFSGVFGVAFGVVFAMMTGNAKDFYLPGMLYTLGLAVAYIVTTLCGVPLIGLILGPVFKENLSWRTRNPGRKKAYAKASWAWGLILLAKCAILFPMYWWADTTKFGWVLIALKIPPFLLAVWLTWVFLAKAPAPIDVFAEMEAQEKAEKEAKAAGTETGARHRREA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-05-25" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K2I2</accession>
    <name>A0A2M9K2I2_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Peptidase M20 domain-containing protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_01800</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M20A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000001">
        <property type="protein sequence ID" value="PJN13339.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN13339">
        <property type="protein sequence ID" value="PJN13339"/>
        <property type="gene ID" value="CG723_01800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016805">
        <property type="term" value="F:dipeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017439">
        <property type="entry name" value="Amidohydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036264">
        <property type="entry name" value="Bact_exopeptidase_dim_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002933">
        <property type="entry name" value="Peptidase_M20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011650">
        <property type="entry name" value="Peptidase_M20_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017144">
        <property type="entry name" value="Xaa-Arg_dipeptidase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07687">
        <property type="entry name" value="M20_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01546">
        <property type="entry name" value="Peptidase_M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037226">
        <property type="entry name" value="Amidohydrolase_ACY1L2_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55031">
        <property type="entry name" value="SSF55031"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01891">
        <property type="entry name" value="amidohydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="M20_dimer" evidence="2">
        <location>
            <begin position="173"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRNR" id="PIRNR037226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN13339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="394" mass="40676" checksum="F5CCD61FC3618E90" modified="2018-04-25" version="1">MTDTPTARKTVTGAVRNWREQVVALSHALHDDPETALEEHRAAARIADLMEGAGFDVTRGAGGLPTAVLATYGTGDLVIAFCAEYDALPGIGHACGHNVNGAASVGAALGLAAVADELGVTVKLIGTPAEEDIGGKVLLMDAGIFDDVAAAMMVHAAPDDTVGASSLAIGAWDLAYRGRPSHAALAPWEGVNALDAMTVAQTAVGLLRQQLPPGVVVHGIITDGGQAVNVIPARTAARYEVRARTVEQLAEAWQRVRACFEAGALATGAELEASAHGRDFADLRQDEEMTRSYARAAGELGRTVTSLHGETMASTDMGNVSQRIPTIHPTVGYDTGGAKQHTPEFTAHGKTPGADLAVLDGATALALVGVDLATSEAQRVRLLDGVGKRRAHAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-09-29" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K2L2</accession>
    <name>A0A2M9K2L2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CG723_01950</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000001">
        <property type="protein sequence ID" value="PJN13365.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN13365">
        <property type="protein sequence ID" value="PJN13365"/>
        <property type="gene ID" value="CG723_01950"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00207">
        <property type="entry name" value="fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002888">
        <property type="entry name" value="2Fe-2S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036884">
        <property type="entry name" value="2Fe-2S-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036010">
        <property type="entry name" value="2Fe-2S_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001041">
        <property type="entry name" value="2Fe-2S_ferredoxin-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006058">
        <property type="entry name" value="2Fe2S_fd_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00111">
        <property type="entry name" value="Fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01799">
        <property type="entry name" value="Fer2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47741">
        <property type="entry name" value="SSF47741"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54292">
        <property type="entry name" value="SSF54292"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00197">
        <property type="entry name" value="2FE2S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51085">
        <property type="entry name" value="2FE2S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="2Fe-2S ferredoxin-type" evidence="3">
        <location>
            <begin position="1"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="103"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="108"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PJN13365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="209" mass="21844" checksum="B81FB1E6DF378F5F" modified="2018-04-25" version="1">MRVNFTVNGRQQEADDVWEGESLLYVLRERMGLPGSKNACEQGECGSCTVRLDGVPVCSCLVAAGQVEGRDVVTVEGLADFARQRAQHGGCASGACGDDAGKAGKAGTSLQDAQQWQSKPSDSQTGEGDELSPIQQAFIDAGAVQCGFCTPGLLVAADEMLERNPDPSDADIREGLSGNLCRCTGYEKIMDAVRLAAARQSATVPSQGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-05-25" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K2P5</accession>
    <name>A0A2M9K2P5_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Enoyl-CoA hydratase 2</fullName>
            <ecNumber evidence="1">4.2.1.119</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Enoyl-CoA hydratase 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CG723_01585</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CB01635</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>a (3R)-3-hydroxyacyl-CoA = a (2E)-enoyl-CoA + H2O</text>
            <dbReference type="Rhea" id="RHEA:26526"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:57319"/>
            <dbReference type="ChEBI" id="CHEBI:58856"/>
            <dbReference type="EC" id="4.2.1.119"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.119" evidence="1"/>
    <dbReference type="EMBL" id="NNBL01000001">
        <property type="protein sequence ID" value="PJN13297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN13297">
        <property type="protein sequence ID" value="PJN13297"/>
        <property type="gene ID" value="CG723_01585"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03450">
        <property type="entry name" value="NodN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002539">
        <property type="entry name" value="MaoC-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039375">
        <property type="entry name" value="NodN-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01575">
        <property type="entry name" value="MaoC_dehydratas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="SSF54637"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="2" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MaoC-like" evidence="5">
        <location>
            <begin position="15"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00029334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00030115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PJN13297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="151" mass="16137" checksum="0EF2BDEE920419C8" modified="2018-04-25" version="1">MGITVNGLDELKKLAGSDLGSSEWTDVTQERIGTFADATDDHQWIHADPERAKEGPFGAPIAHGYLTLSLFIPMFTELLDVEGVTTKVNYGLNKVRFPAPVPAGSRIRLAARLAGVEDVPGGVQITVDGTVEIEGAAKPACVLQSVSRFYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K2Q1</accession>
    <name>A0A2M9K2Q1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CG723_02230</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000001">
        <property type="protein sequence ID" value="PJN13414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN13414">
        <property type="protein sequence ID" value="PJN13414"/>
        <property type="gene ID" value="CG723_02230"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PJN13414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="152" mass="17125" checksum="65A3DC405114BF8F" modified="2018-04-25" version="1">MDAALIAVLGTLLGSVVTHFFQARSTERVAGLARAEQLRQERISSYSAFAGALFDYRRSQNDRWFRAHEVPGSTQAEEARFASYEARISARQALARLQLVCDRADTRQLAESSFELANCLHEAVDEEDRDRRSQRCKDALTRFIDSAAPSVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K2Q8</accession>
    <name>A0A2M9K2Q8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Peptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CG723_02240</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000001">
        <property type="protein sequence ID" value="PJN13416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN13416">
        <property type="protein sequence ID" value="PJN13416"/>
        <property type="gene ID" value="CG723_02240"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PJN13416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="210" mass="22400" checksum="77DBEFCE86A7AED2" modified="2018-04-25" version="1">MTFCTTCALPSLTQFASPQLVEAIVEGGHDRADDPAWETSGAATVEDYALWCGHLCGLTCLRMALGPDAPSLFDLRDGALKYGAYTVDPEGGIHGLIYAPFAEYAREELGLDATVHRTLTTDEIAGLLDTGRTVMASVHYGIRRPERPAPGRGGHLVLLTARDGDRFHFHNPSGISPETRCAELPSATFETFFAGRGVSLSAGHGADPRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K2W2</accession>
    <name>A0A2M9K2W2_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 3">Methionine aminopeptidase</fullName>
            <shortName evidence="2">MAP</shortName>
            <shortName evidence="2">MetAP</shortName>
            <ecNumber evidence="2 3">3.4.11.18</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Peptidase M</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2 5" type="primary">map</name>
        <name evidence="5" type="ORF">CG723_02505</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CB01635</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 2">Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). Requires deformylation of the N(alpha)-formylated initiator methionine before it can be hydrolyzed.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 3">
            <text>Release of N-terminal amino acids, preferentially methionine, from peptides and arylamides.</text>
            <dbReference type="EC" id="3.4.11.18"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 3">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
        <cofactor evidence="2 3">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <cofactor evidence="2 3">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <cofactor evidence="2 3">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <text evidence="2 3">Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe(2+)-metalloproteases under physiological conditions, and the catalytically relevant metal-binding site has been assigned to the histidine-containing high-affinity site.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase M24A family. Methionine aminopeptidase type 1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.11.18" evidence="2 3"/>
    <dbReference type="EMBL" id="NNBL01000001">
        <property type="protein sequence ID" value="PJN13459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN13459">
        <property type="protein sequence ID" value="PJN13459"/>
        <property type="gene ID" value="CG723_02505"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046914">
        <property type="term" value="F:transition metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070084">
        <property type="term" value="P:protein initiator methionine removal"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01086">
        <property type="entry name" value="MetAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01974">
        <property type="entry name" value="MetAP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036005">
        <property type="entry name" value="Creatinase/aminopeptidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000994">
        <property type="entry name" value="Pept_M24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001714">
        <property type="entry name" value="Pept_M24_MAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002467">
        <property type="entry name" value="Pept_M24A_MAP1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00557">
        <property type="entry name" value="Peptidase_M24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00599">
        <property type="entry name" value="MAPEPTIDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55920">
        <property type="entry name" value="SSF55920"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00500">
        <property type="entry name" value="met_pdase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 5" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 3" id="KW-0645">Protease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase_M24" evidence="4">
        <location>
            <begin position="12"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="83"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="100"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="111"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="174"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="181"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="207"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002521"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PJN13459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="255" mass="26447" checksum="612C605BBE439A86" modified="2018-04-25" version="1">MVELKTDTSIDEMREAGRVVAQALAAVREKAAVGVSLLELDSVAHGVLRAADAGSPFLGYRPSFAPTPFPAVLCASVNDAIVHGIPDGYRLRDGDLLSADFGAELGGWAGDSAISFTVGKARPEDLHLIETAERALAAGIAAAVVGNRIGDIAHAIGKVCRAEGYGIPDGFGGHGIGRKMHEDPPVPNEGRAGRGMRLKHGMVLAIEPMVIAGGMDDYYAAPDGWTLRTGDGTRAAHAEHTVAITDAGPRILTAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K3A9</accession>
    <name>A0A2M9K3A9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">TetR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_03405</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000001">
        <property type="protein sequence ID" value="PJN13614.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN13614">
        <property type="protein sequence ID" value="PJN13614"/>
        <property type="gene ID" value="CG723_03405"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="22"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="44"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN13614.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="196" mass="21728" checksum="99645E63EBA93E2C" modified="2018-04-25" version="1">MTDRELVGGIVAAQRPRRADARRNFDALLAAARDAFAEKGAEASLEDIARKAGVGIGTLYRNFPTRRHLFETVYAEEVDALCRLADELADAPPWDGLATWLRRFVDYTVTKRAIRDALSGESDIFVSCRRAMIDAGEPLLLRAQAAGEVREDMSFDDLLRLISGVTGAAYVDTEQRDRVFGITLDGMRTRPAPRKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K3B2</accession>
    <name>A0A2M9K3B2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">TetR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CG723_03420</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000001">
        <property type="protein sequence ID" value="PJN13616.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN13616">
        <property type="protein sequence ID" value="PJN13616"/>
        <property type="gene ID" value="CG723_03420"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011075">
        <property type="entry name" value="TetR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16859">
        <property type="entry name" value="TetR_C_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="3">
        <location>
            <begin position="21"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="44"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PJN13616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="206" mass="22149" checksum="C09B75BB92D61797" modified="2018-04-25" version="1">MESQEQAGTSVTTSRRSKITPEREREFYDAVLDQLRENGYEALTMEGVAAQACCSKSTLYRQWKTKPQLVAAALRAGRCVKFASVDTGTFAGDLRSAARAAAQQAGRDTQLVQALGHAVLSDEELQGALREALVEPELAALGAMVDRAVARGEIAADHPAVEFLAAQLLGVQRIRPVLEGRYADADYLTRFVDAVVLPALGLSEAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JEP4</accession>
    <name>A0A2M9JEP4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_45180</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000051">
        <property type="protein sequence ID" value="PJN05364.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN05364">
        <property type="protein sequence ID" value="PJN05364"/>
        <property type="gene ID" value="CG723_45180"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="26"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN05364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="109" mass="11728" checksum="4996912046CE36C9" modified="2018-04-25" version="1">MYVIHAGLLVKTLTAPIPHQRRAKLTGARTATTPLPPPPSQPRRAVRRVGADGTFLVARHKLRPGVAHAGKTVTVVIEETCFRVLDGEVEISTHPLKGGPATRYIAGPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JFM4</accession>
    <name>A0A2M9JFM4_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Histidine kinase</fullName>
            <ecNumber evidence="3">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CG723_43560</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CB01635</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="3"/>
    <dbReference type="EMBL" id="NNBL01000043">
        <property type="protein sequence ID" value="PJN05688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN05688">
        <property type="protein sequence ID" value="PJN05688"/>
        <property type="gene ID" value="CG723_43560"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00672">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00304">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015006580" description="Histidine kinase" evidence="7">
        <location>
            <begin position="23"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="9">
        <location>
            <begin position="186"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="8">
        <location>
            <begin position="263"/>
            <end position="477"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PJN05688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="493" mass="51884" checksum="25ABD23C23C16761" modified="2018-04-25" version="1">MSGRRQPRSLRKRLVITAVALIALVCAVIGTVTTIALHTYLYDQLDKQVRGAVVQSTGGPGPERQAQNLNFLGGPSRPGTIGALVESDGSVTEAAKSVADRDNPVVPLTDAQITALESVPQDGGTHSVSVPGLGDYRISSKPGGNTMVGLPETEVQDTLSTLIVVEVSVTAAGLVAASLAGAAMVGVALRPLRRVASTATRVSELPLHSGEVALHERVPDTEADPRTEVGQVGAALNRMLDHVNGALEARQQSETRVRQFVADASHELRTPLASIRGYAELTRRGREETGPDTRHALGRIESEAHRMTGLVEDLLLLARLDSGRPLSYEATDLSPLVVDALSDARAAGQDHAWRLELPDDPALVLADGQRIHQVLVNLLANARTHTPPGTTVTARVHRQGPWVCLDVQDNGPGIPPELLPHVFERFARGDTSRSRAHGSTGLGLAIVQAVAAAHGGAVTVDSVPGRTVFTVHLPACGEPVTHSQAGHSLTTLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JFN8</accession>
    <name>A0A2M9JFN8_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">L-aspartate dehydrogenase</fullName>
            <ecNumber evidence="6">1.4.1.21</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">nadX</name>
        <name evidence="9" type="ORF">CG723_43075</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CB01635</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Specifically catalyzes the NAD or NADP-dependent dehydrogenation of L-aspartate to iminoaspartate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>H2O + L-aspartate + NAD(+) = H(+) + NADH + NH4(+) + oxaloacetate</text>
            <dbReference type="Rhea" id="RHEA:11788"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16452"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.4.1.21"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>H2O + L-aspartate + NADP(+) = H(+) + NADPH + NH4(+) + oxaloacetate</text>
            <dbReference type="Rhea" id="RHEA:11784"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16452"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.4.1.21"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="6">Cofactor biosynthesis; NAD(+) biosynthesis; iminoaspartate from L-aspartate (dehydrogenase route): step 1/1.</text>
    </comment>
    <comment type="miscellaneous">
        <text evidence="6">The iminoaspartate product is unstable in aqueous solution and can decompose to oxaloacetate and ammonia.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the L-aspartate dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.4.1.21" evidence="6"/>
    <dbReference type="EMBL" id="NNBL01000042">
        <property type="protein sequence ID" value="PJN05715.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN05715">
        <property type="protein sequence ID" value="PJN05715"/>
        <property type="gene ID" value="CG723_43075"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00253">
        <property type="reaction ID" value="UER00456"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033735">
        <property type="term" value="F:aspartate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016639">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009435">
        <property type="term" value="P:NAD biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01265">
        <property type="entry name" value="NadX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005106">
        <property type="entry name" value="Asp/hSer_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002811">
        <property type="entry name" value="Asp_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020626">
        <property type="entry name" value="Asp_DH_prok"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011182">
        <property type="entry name" value="L-Asp_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01958">
        <property type="entry name" value="DUF108"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03447">
        <property type="entry name" value="NAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005227">
        <property type="entry name" value="Asp_dh_NAD_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0520">NAD</keyword>
    <keyword evidence="3 6" id="KW-0521">NADP</keyword>
    <keyword evidence="4 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2 6" id="KW-0662">Pyridine nucleotide biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD_binding_3" evidence="8">
        <location>
            <begin position="11"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="domain" description="DUF108" evidence="7">
        <location>
            <begin position="164"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="216"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="117"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="186"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF03447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PJN05715.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="265" mass="27670" checksum="F2316B90DFD40F44" modified="2018-04-25" version="1">MSTVRKVGLVGWGAIGRVVGTALAEQKVPGAELTCIIDNRPLGDTAPAPQRTFDEALECCDLIVEAAGQGVVREWGERVLASGTDLLVASTGALTDDELSKRLLAAGPGRVYFTGGAVGGLDLLQAVRSLGPLDEVRLTTTKLPSTLEQPWMDEELLSRLRTATGPVEVMSGTARDIPVKFPKSTNVAASVALAVGDLDAVRVRVVADPGARHTRHVVEASGAHGAYRFDVAHLPDPGNPATSQVVPYAVLRSLAALAGRTGQIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JFP0</accession>
    <name>A0A2M9JFP0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">IclR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CG723_43000</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000042">
        <property type="protein sequence ID" value="PJN05701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN05701">
        <property type="protein sequence ID" value="PJN05701"/>
        <property type="gene ID" value="CG723_43000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014757">
        <property type="entry name" value="Tscrpt_reg_IclR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005471">
        <property type="entry name" value="Tscrpt_reg_IclR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09339">
        <property type="entry name" value="HTH_IclR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01614">
        <property type="entry name" value="IclR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00346">
        <property type="entry name" value="HTH_ICLR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51077">
        <property type="entry name" value="HTH_ICLR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51078">
        <property type="entry name" value="ICLR_ED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH iclR-type" evidence="3">
        <location>
            <begin position="5"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="domain" description="IclR-ED" evidence="4">
        <location>
            <begin position="68"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PJN05701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="254" mass="27578" checksum="EFAD0149F6E27AF3" modified="2018-04-25" version="1">MARNIQSLERAAAMLRLLAGGERRLGLSDIASTLGLAKGTAHGILRTLQHEGFVEQDAPSGRYQLGAELLRLGNSYLDVHELRARALVWTDDLARSSGESVYLGVLHQQGVLIVHHVFRPDDSRQVLEVGAMQPLHSTALGKVLSAYDPVAHSEVVEVDRKAFTGRTVSDIVEFETLLDLTRARGYADDVEETWEGVASVAAPIHDRRRMPVGAVGITGAVERVCVDGDLRPELVAAVRDCARAVSRDLGASRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JFR8</accession>
    <name>A0A2M9JFR8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Chitinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CG723_43250</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000042">
        <property type="protein sequence ID" value="PJN05745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN05745">
        <property type="protein sequence ID" value="PJN05745"/>
        <property type="gene ID" value="CG723_43250"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0110165">
        <property type="term" value="C:cellular anatomical entity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016798">
        <property type="term" value="F:hydrolase activity, acting on glycosyl bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003305">
        <property type="entry name" value="CenC_carb-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001223">
        <property type="entry name" value="Glyco_hydro18_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02018">
        <property type="entry name" value="CBM_4_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00041">
        <property type="entry name" value="fn3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="SSF49265"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="SSF49785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51910">
        <property type="entry name" value="GH18_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014967900" evidence="3">
        <location>
            <begin position="38"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="4">
        <location>
            <begin position="179"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="domain" description="GH18" evidence="5">
        <location>
            <begin position="274"/>
            <end position="563"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PJN05745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="563" mass="57856" checksum="5CC3C34E9CCD7927" modified="2018-04-25" version="1">MFSRRKRRSARPRLLALIGSAALAVAGAVALPTTAQAANVLSNAGFESGSTSPWTCSGGLGSVVSSPVHGGTKALSGAAGSSDNAKCSQTVSVQPNTAYTLSGWVRGNYVYLGVDGGASTWTQSPTAYSQLTVQFTTGASQTSATIYTQGWYAQGTYYADDISLDGPGGGGGDTQAPTVPTALKSTGKTSTSVSLSWTGASDNVGVTGYDIYSGGSNKLLTVSGTSATVSGLSPSTAYAFTVKAHDAAGNASAASNSVSVTTDQGSGGGTGFKQAAPYFYTGWGDPPSPATVMNATGVKWFTMAFILSSGGCNPAWDGQRALTGGQDQTAINAIRSAGGDVVPSIGGWSGNKLGPNCSTPEALAGAYQKVIDAYGLKAIDVDIENSDEFENEAVQDRILGALKIVKANNPGLRTILTFGTSTTGPTYYGNRLIEQSKALNADIDVFTIMPFDFGGGSDMYGNTVNAADGLKTKLKSVFGWDDTTAYGHIGISGMNGVSDQQETTTPAIWTQVKDWSNSHHIARLAFWSVNRDRPCAGGGVAENCSGISQDNWQFTKITAGFTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JFS5</accession>
    <name>A0A2M9JFS5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Peptide ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CG723_43235</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CB01635</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000042">
        <property type="protein sequence ID" value="PJN05744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN05744">
        <property type="protein sequence ID" value="PJN05744"/>
        <property type="gene ID" value="CG723_43235"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="103"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="137"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="191"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="249"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="295"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="101"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PJN05744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="329" mass="35885" checksum="844E724FDB932853" modified="2018-04-25" version="1">MRFILRRLGFFLLTLWAALTLNFFIPRFMPGDPVDALVVRTRGRVSRDALEQMLTSFGFKPDQNVAVQYFDYLGHMFTGNWGRSIGQTLGEPVTKLIGGALPWTLGLVGITTVLAFVLGTLIGTVSGWRRGGALDAVLPPIFVITSALPYFWVGLLLILVFSQGTGGWLPANFNYDTSIVPGFSPGFVGSVLSHAVLPAATLLITTIGGWILTMRNNMITTLAEDYVRMARAKGLGSRRIMYGYAARNAILPNLAGFAMSLGFVISGAILIEYVFNYPGIGYLLYNAVQNVDYPLMQALFMLFTVAVLVALLAVDIATVWLDPRARAKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JG02</accession>
    <name>A0A2M9JG02_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CG723_43230</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CB01635</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000042">
        <property type="protein sequence ID" value="PJN05743.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN05743">
        <property type="protein sequence ID" value="PJN05743"/>
        <property type="gene ID" value="CG723_43230"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="34"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="98"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="129"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="156"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="202"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="266"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="94"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PJN05743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="307" mass="32446" checksum="BCAA0118E3663CDC" modified="2018-04-25" version="1">MTTTAITAPPPEKASARTRAGGGLWRAVRGNRKAMAGAVILLIFTVVAAFPGLFTSVDHPDEANFAPRLDPSTAHLLGTTALGQDIYSQLIYGTRESLVIAVVAGALATVLSVIVGVSAAYLGGIADDLLSLLTNVVLVIPAFPLVIILAKYAGKGSLTVILAVLVLTGWSYGANQLRAQALSLRNRDFLESARVRGERRSYIIVFEVLPTMTSLIVANFLGAALYSVLSAAGLQFLGLGDPNSQSWGTMLYWAQNQQALQTGTPLWSIAPGLCVALLGVAFALVNYAFDEIGNPALRPVRRRRKGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JG08</accession>
    <name>A0A2M9JG08_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Valine dehydrogenase</fullName>
            <ecNumber evidence="6">1.4.1.23</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CG723_42545</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">CB01635</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>H2O + L-valine + NAD(+) = 3-methyl-2-oxobutanoate + H(+) + NADH + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:30763"/>
            <dbReference type="ChEBI" id="CHEBI:11851"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57762"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.4.1.23"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid degradation; L-valine degradation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 12">Belongs to the Glu/Leu/Phe/Val dehydrogenases family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.4.1.23" evidence="6"/>
    <dbReference type="EMBL" id="NNBL01000040">
        <property type="protein sequence ID" value="PJN05821.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN05821">
        <property type="protein sequence ID" value="PJN05821"/>
        <property type="gene ID" value="CG723_42545"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00362"/>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043837">
        <property type="term" value="F:valine dehydrogenase (NAD) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006574">
        <property type="term" value="P:valine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046346">
        <property type="entry name" value="Aminiacid_DH-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006095">
        <property type="entry name" value="Glu/Leu/Phe/Val_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033524">
        <property type="entry name" value="Glu/Leu/Phe/Val_DH_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006096">
        <property type="entry name" value="Glu/Leu/Phe/Val_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006097">
        <property type="entry name" value="Glu/Leu/Phe/Val_DH_dimer_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016211">
        <property type="entry name" value="Glu/Phe/Leu/Val_DH_bac/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42722">
        <property type="entry name" value="PTHR42722"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00208">
        <property type="entry name" value="ELFV_dehydrog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02812">
        <property type="entry name" value="ELFV_dehydrog_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000188">
        <property type="entry name" value="Phe_leu_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00082">
        <property type="entry name" value="GLFDHDRGNASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00839">
        <property type="entry name" value="ELFV_dehydrog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53223">
        <property type="entry name" value="SSF53223"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00074">
        <property type="entry name" value="GLFV_DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0101">Branched-chain amino acid catabolism</keyword>
    <keyword evidence="11" id="KW-0520">NAD</keyword>
    <keyword evidence="11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9 12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ELFV_dehydrog" evidence="13">
        <location>
            <begin position="155"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="10">
        <location>
            <position position="91"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="191"/>
            <end position="196"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00017332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000188-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR000188-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU004417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="PJN05821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="363" mass="38279" checksum="650507F75F62BEA5" modified="2018-04-25" version="1">MTDVTGAPADVLHTLFRSDQGGHEQVVLCQDRASGLKAVIAIHSTALGPALGGTRFYPYASEAEAVADALNLSRGMSYKNAMAGLDHGGGKAVIIGDPETIKSEELLLAYGRFVASLGGRYVTACDVGTYVADMDVVARECRWTTGRSPENGGAGDSSVLTAFGVFQGMRASAQHLWGDPTLRDRKVGVAGVGKVGHHLVEHLLSDGAEVVITDVRAESVRRIQDKHPSVRAVADTETLIRTEGLDIYAPCALGGALDDHSVPVLTAKIVCGAANNQLAHPGVEKDLADRGILYAPDYVVNAGGVIQVADELHGFDFDRCKAKAAKIFDTTLAIFARAKADGIPPAAAADRIAEQRMAEARRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JG86</accession>
    <name>A0A2M9JG86_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">PPM-type phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CG723_42640</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000040">
        <property type="protein sequence ID" value="PJN05833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN05833">
        <property type="protein sequence ID" value="PJN05833"/>
        <property type="gene ID" value="CG723_42640"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07228">
        <property type="entry name" value="SpoIIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00331">
        <property type="entry name" value="PP2C_SIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="SSF81606"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="66"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="113"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="domain" description="PPM-type phosphatase" evidence="3">
        <location>
            <begin position="188"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="23"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PJN05833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="414" mass="43545" checksum="F4970E284257C68D" modified="2018-04-25" version="1">MVSRLGPLSPGRSRQVARCLLRGNPGVGPDDVRRRGTDADGGGRRAVGQRGGHGREAEQGLSRARFFVRLLPVLLIVVGAIYDYVTPSTFTGVPLFTAAPLVAAPFFSPRGTFLTGLATVAVVLGVHLRYTRSYDTDAITELVTVVTVAVLACVMNRVVRRGSEQLTSVRQIAEAAQRAVLPEPAERIGGLEIAARYEAAQAGAFIGGDLYAVQDTPHGVRLVVGDVRGKGMGAVSAVAVVIGAFREAAEQEATLEAVAQRLERALAREGLRRNGLDESEGFTTAVLAEIPHGNALVRVINRGHPEPLILGGDGALKVLSPPEPALPLGMGGLGSWPDRASETEFPSGATLLLYTDGLSEARDAEGTFYDPAARLAGRMFSGPDPLLAALTAEVRRHTGGGTTDDMALLAVRRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JG98</accession>
    <name>A0A2M9JG98_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_41970</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000038">
        <property type="protein sequence ID" value="PJN05904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN05904">
        <property type="protein sequence ID" value="PJN05904"/>
        <property type="gene ID" value="CG723_41970"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="2">
        <location>
            <begin position="27"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="18"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="79"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="153"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="114"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="165"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN05904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="534" mass="57850" checksum="0F1826FED849D884" modified="2018-04-25" version="1">MSEFDAIDSLLASLTPQEELPDTEVRRSLREQAGLSKAQVARALGVSPSTVTGWESGRDPAGETRAKYAYLLDGLAAKFAPPAEPESEAEAGPEPEADEVAPAPVAATDATEPSPADDTDDRDDADDVETLATPEPCVLCASPARQRVAGFPQHLDPADCRPTAGTTTPAVTPAAPSAPQVQPSRTARPSHAAHGAQQPKKPAPRGRAFQEPSGPADAIHQAVQAALAAHEGDVEAASATLLKRAIPDAMALLDQTRKGARYDVIAHPWIPDILKKQTAKGADRIWEARPKWTRHELPPGEHEVTALDINGAYLSALKTHLPLGQLEHSTGFDHDRRRAGVHLITPPHWEHEAVLPNPIGNRDEPGPLWVTEPTLRLLLRLSGPKYGLCDPPQIHESYTSGATENLLEKFRIALKDAREQAISDGDEVTLEYVKAMYSKFVSTMGESNYNRELYRPDWMHLIRSQAFANLWTKAYKAHEEGLTVVRAMGTDELHVIGDWHSVFPEGRGVTEVKVKDIYTAGAAGDEALHEGEGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JGP8</accession>
    <name>A0A2M9JGP8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CG723_41385</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CB01635</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000036">
        <property type="protein sequence ID" value="PJN06056.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN06056">
        <property type="protein sequence ID" value="PJN06056"/>
        <property type="gene ID" value="CG723_41385"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044566">
        <property type="entry name" value="RMV1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45826">
        <property type="entry name" value="PTHR45826"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="53"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="96"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="151"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="180"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="218"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="257"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="293"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="352"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="377"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="419"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="442"/>
            <end position="462"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PJN06056.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="497" mass="52439" checksum="FCE04D18C4F74F66" modified="2018-04-25" version="1">MTELIPSENTRSAPGAGRRTLGVLPLVGIFFFTVSGGPFGLEASLSSAGPGMTLLMIVLVPVVFGVPNALVAAELSAAIPVNGGYYYWTKLALGRGAAFVFGAWNSIGSVLNLALYPILLVDYLATWVPDIARGKGLVIVDLFHGGFVVDLHWIVTVALIVPMAYLNYRGSKAVSEYSVGMMLLILAPFAVLAVLGIWHAVGNGINVLSPFMVPGQSAHSSVAGALSVIVWLYLGFDGPSTVLGEVADAHRTYTRALVISVPLIITAYLLPTIAAIGSGLHRGSPADWAQGDFIVVGGALGGIWLKVLISLGSALSLVGLFMAILLTSTRVPRALAADAYLPRWMARDSRRFNTPVGALLASTTVVVVLSAVDFSSILRATVLLTLASILLEFVAFLVLRWRYPQMLRPVRVPGGWPGAVLVVVLPTAMIVYLAWSTAVDEAATFGTSLAVALLAVLLYPLCRRFVKGDRPDAAIDSSQVELGPDRFAGFGSRKAGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-09-29" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JHL4</accession>
    <name>A0A2M9JHL4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Molybdopterin dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_39450</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000031">
        <property type="protein sequence ID" value="PJN06342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN06342">
        <property type="protein sequence ID" value="PJN06342"/>
        <property type="gene ID" value="CG723_39450"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.43.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005107">
        <property type="entry name" value="CO_DH_flav_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036683">
        <property type="entry name" value="CO_DH_flav_C_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016167">
        <property type="entry name" value="FAD-bd_PCMH_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002346">
        <property type="entry name" value="Mopterin_DH_FAD-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03450">
        <property type="entry name" value="CO_deh_flav_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00941">
        <property type="entry name" value="FAD_binding_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01092">
        <property type="entry name" value="CO_deh_flav_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55447">
        <property type="entry name" value="SSF55447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="SSF56176"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="1">
        <location>
            <begin position="1"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN06342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="330" mass="34547" checksum="6DA026255BBB1F2E" modified="2018-04-25" version="1">MKEFGYERVFDVPAAVALLDADPDARCLGGGTNLVDLMKTGVERPARLVDVRELPLGEIELTPEGGLRIGATVTNSDLAAHPEVRRRYPMLAQAVLAGASGQLRNMATVGGNLLQRTRCGYFTDLAKPCNKRTPGSGCPAIEGEHHNAAILGASAHCVAVHPSDMGVVLAALDAVVSYETVDGPGELALAEFYSPVGETPHVETALPPGALITAVILPPAPVAALSRYRKVRERASYAFAIGSVAAALDVRDGTVHEVRLAFGAVASRPWRAHEAERALTGGPATAEAFAAAADAELAAAETLPHNGYKVTLMRNLVVAVLTELAEEAVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JI24</accession>
    <name>A0A2M9JI24_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GNAT family N-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_38975</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000029">
        <property type="protein sequence ID" value="PJN06535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN06535">
        <property type="protein sequence ID" value="PJN06535"/>
        <property type="gene ID" value="CG723_38975"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13302">
        <property type="entry name" value="Acetyltransf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="9"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN06535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="173" mass="19369" checksum="43E4193F428E4855" modified="2018-04-25" version="1">MTEIQTPRLLLRRWSDDDLVPLSEIQADPDVMRRVGDGGPRDLERTAEDIERWEEEWDEEGFGPFAVELLASGELAGVVGLSVSELQPGIEINWWLGHQFWGQGYASEAAQATLEFALQDRGVDRVVALIRPGDTGSENVARKLGMTEGREFAHPKHGFALQVHEIDLTEYEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JI30</accession>
    <name>A0A2M9JI30_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Macrolide ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CG723_38205</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000028">
        <property type="protein sequence ID" value="PJN06541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN06541">
        <property type="protein sequence ID" value="PJN06541"/>
        <property type="gene ID" value="CG723_38205"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042953">
        <property type="term" value="P:lipoprotein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03255">
        <property type="entry name" value="ABC_MJ0796_LolCDE_FtsE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015854">
        <property type="entry name" value="ABC_transpr_LolD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017911">
        <property type="entry name" value="MacB_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24220:SF654">
        <property type="entry name" value="PTHR24220:SF654"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="8"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="40"/>
            <end position="47"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PJN06541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="228" mass="24072" checksum="E047AF8B39A7AFF4" modified="2018-04-25" version="1">MTPAGSLLTADGLHKTYGATKALNGAEFSVHPGEVVAVMGPSGSGKSTLLHCLAGIVPPDEGAITYAGQNLATMSDAARSALRRSDFGFVFQFGQLVPELTCLENVALPLRLNGARRKAAEATARTWMERLEVDDLTGKRPGEVSGGQGQRVAVARALATSPRVLFADEPTGALDSLNGERVMELLTDAARSTNAAVVLVTHEARVAAYSDREIIVRDGKSRDMERIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-09-29" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JI68</accession>
    <name>A0A2M9JI68_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">N-acyl-D-amino-acid deacylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_38435</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000028">
        <property type="protein sequence ID" value="PJN06579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN06579">
        <property type="protein sequence ID" value="PJN06579"/>
        <property type="gene ID" value="CG723_38435"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016811">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013108">
        <property type="entry name" value="Amidohydro_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023100">
        <property type="entry name" value="D-aminoacylase_insert_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07969">
        <property type="entry name" value="Amidohydro_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="SSF51338"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydro_3" evidence="1">
        <location>
            <begin position="50"/>
            <end position="514"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN06579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="533" mass="57868" checksum="414DF9C3C5CA4424" modified="2018-04-25" version="1">MTDLVIKDVRVIDGTGTPEYRADVAITDGRIESIHQERAGGPRPSARRTLEASGLALSPGFIDMHAHSDLALLRDPDHSAKAAQGVTLEVLGQDGLSYAPVDDRTLAEVRRAITGWNGDGSDIDFDWRTVGEYLDRLDRGIAVNAAYLIPQGTVRMYAVGWDDRDATPEELDRMRQLVAEGMEQGAVGMSSGLTYTPGMYAKDAELTELCRVVASYDGYYCPHHRSYGAGALDAYREMVELTREAGCPLHLAHATMNFGVNKGKAPELITLLDAALADGADISLDTYPYTPGSTTLVAMLPSWASEGGPDEIMKRLQDDATAEKIRHHMEVIGADGCHGVPIEWDAIEISGVSDPGLASCVGRTVQESADMRGEAPWVTARRLLIDDKLGSTILQHVGHEENVRAIMQHPVHTGGSDGILQGFKPHPRAYGTFPHYLGRYARELGIMSLEETVAHLTSRPAARLRLADRGLVREGYRADLVLFDPETVAAGSTFEAPRTLPVGIPHVLIDGKFVMEDGRRTDALAGRSVRRTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JJN6</accession>
    <name>A0A2M9JJN6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Polysaccharide deacetylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_36510</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000024">
        <property type="protein sequence ID" value="PJN06987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN06987">
        <property type="protein sequence ID" value="PJN06987"/>
        <property type="gene ID" value="CG723_36510"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd10938">
        <property type="entry name" value="CE4_HpPgdA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002509">
        <property type="entry name" value="NODB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037950">
        <property type="entry name" value="PgdA-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01522">
        <property type="entry name" value="Polysacc_deac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="SSF88713"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51677">
        <property type="entry name" value="NODB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NodB homology" evidence="1">
        <location>
            <begin position="42"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN06987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="290" mass="32859" checksum="D7F25687AFBB94B3" modified="2018-04-25" version="1">MHTPADPRPPRWPHGRRSAVALAFDLDGPTGGAMLDGSLWDRPGYFALGGYGPHRALPRLLDLLDDGGVPATFFTPAWVVEHWPQACRQIVERGHEVAHHGYRHECYYDLTADEQADVITRSQRVFRDVLGTEATGFRSPSGDWHPETPRILRDHGFRYSSSMRGDDRPYRHTVDGVTTDLVEIPARWDLDDYAFLAYHRNPDYPSGQDRIASYALALDNWKREFDGYRAEGLCLTTLFHPKVSGRPGRLLILEELIAHMRAHDDVWFARCDDVADWWIESGQGAQVAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-05-25" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JJY5</accession>
    <name>A0A2M9JJY5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CG723_34890</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">CB01635</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000022">
        <property type="protein sequence ID" value="PJN07183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN07183">
        <property type="protein sequence ID" value="PJN07183"/>
        <property type="gene ID" value="CG723_34890"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04590">
        <property type="entry name" value="CBS_pair_CorC_HlyC_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002550">
        <property type="entry name" value="CNNM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044751">
        <property type="entry name" value="Ion_transp-like_CBS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005170">
        <property type="entry name" value="Transptr-assoc_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03471">
        <property type="entry name" value="CorC_HlyC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01595">
        <property type="entry name" value="DUF21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01091">
        <property type="entry name" value="CorC_HlyC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="SSF54631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="SSF56176"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51846">
        <property type="entry name" value="CNNM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0129">CBS domain</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="10" id="KW-0732">Signal</keyword>
    <keyword evidence="2 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014637722" evidence="10">
        <location>
            <begin position="23"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="domain" description="CNNM transmembrane" evidence="12">
        <location>
            <begin position="1"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="11">
        <location>
            <begin position="221"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="11">
        <location>
            <begin position="286"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="339"/>
            <end position="365"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PJN07183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="446" mass="47006" checksum="CA763CFE585D5303" modified="2018-04-25" version="1">MTEVLLLAVAVLLSLACGAFVAAEFSLTTVERSGLERAVERGERGAAGALKAVRNLTFQLSGAQLGITVTNLVVGMLAQPSVAKLIAGPLESLGLSRSTASSLALVIGTALSTVFLMVVGELVPKNWAISSPLAVAKRVATPQRLFSAAFRPFITHLNNTANRAVRRFGIEPAEELASARGPQELVALARHSAKEGALEADTAELFMRTLNLADLTAENVMTPRVQVVALDAQATCEDVANATRATGLSRFPVYRGNLDSVVGVAHIKDVLAVPAELRGRRSVSDLMREPLLVPETLTVDRLLDRLSGKRTMAVVIDEYGGTAGVATVEDIVEEVVGEVRDEHDPHETPDLAPAGNDGEGRGLYSADGAARTDQLQRVGLRVPHGPYETLAGLVATELGRIPAVGDSVEVAGWRLDVVDAAGHRAARVLLHAPMTGQSDDAPEGDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-05-25" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JJY8</accession>
    <name>A0A2M9JJY8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CG723_34895</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CB01635</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000022">
        <property type="protein sequence ID" value="PJN07184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN07184">
        <property type="protein sequence ID" value="PJN07184"/>
        <property type="gene ID" value="CG723_34895"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04590">
        <property type="entry name" value="CBS_pair_CorC_HlyC_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002550">
        <property type="entry name" value="CNNM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044751">
        <property type="entry name" value="Ion_transp-like_CBS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01595">
        <property type="entry name" value="DUF21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="SSF54631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51846">
        <property type="entry name" value="CNNM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0129">CBS domain</keyword>
    <keyword evidence="5 7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 7 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="6"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="50"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="97"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="domain" description="CNNM transmembrane" evidence="10">
        <location>
            <begin position="1"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="9">
        <location>
            <begin position="220"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="9">
        <location>
            <begin position="282"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PJN07184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="337" mass="36571" checksum="D32556F842F68793" modified="2018-04-25" version="1">MTAIQLLIGLATLVVNAFFVGAEFALISVRRSQIEPHADEGDRRAKSVMWGLQHVSALLAAAQLGITLCTLVLGIVAEPAIAHLLEPLFDAVGVPHGLVHPISFVIALTVATYLHMLLGEMIPKNVALAEPVRSALLLGPPLVTLARALRPVIFTVNAFANGLLKLLRVDVKDEVSATFSDDELARLVKDSGDAGLIDDRAQERLRDALELGRRPVRDVVLPLERVVYAHVGVTPEQLEQLSAQSGFSRFPVVDDNRRIVAYLHVKDALDASPRDLPFRIPDMRSIARVRETTPLDDVLSAMRSSRTHVAAVLGSDGRLAGLVTMEDVLRELFGQPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JJZ8</accession>
    <name>A0A2M9JJZ8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">RNA polymerase subunit sigma-24</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CG723_34955</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CB01635</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2">Interacts transiently with the RNA polymerase catalytic core formed by RpoA, RpoB, RpoC and RpoZ (2 alpha, 1 beta, 1 beta' and 1 omega subunit) to form the RNA polymerase holoenzyme that can initiate transcription.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000022">
        <property type="protein sequence ID" value="PJN07193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN07193">
        <property type="protein sequence ID" value="PJN07193"/>
        <property type="gene ID" value="CG723_34955"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050896">
        <property type="term" value="P:response to stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014303">
        <property type="entry name" value="RNA_pol_sigma-70_ECF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013249">
        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08281">
        <property type="entry name" value="Sigma70_r4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="SSF54427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02957">
        <property type="entry name" value="SigX4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="6">
        <location>
            <begin position="10"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4_2" evidence="7">
        <location>
            <begin position="112"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF08281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PJN07193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="292" mass="31860" checksum="4AE233737A4137AF" modified="2018-04-25" version="1">MATDTVIEVFEEHRPVLMGVAYRMLGRVADAEDVVQDAWLRWAQADRDEVREPRAYLVRVATRLAIDRLRQAQTRREAYVGPWLPEPLVTDFGPTAPDTAEAAVLAESVSLAVLVVLESLSPLERAVFVLREAFGFPFAEIATTLERSESAVRQLAGRARKHVDERRPRFDVDPVEQRDLTERFLAAATGGDLEGLMTLLAPDARLVGDSGGKSKAPLRVIESADKVGRFLLGVAKGGGTGFTFRTVEVNGGPAVLVLVDGKPDSVFQVDVADGQVQCVYIVRNPDKLVSLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JK51</accession>
    <name>A0A2M9JK51_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Iron-sulfur protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CG723_35220</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000022">
        <property type="protein sequence ID" value="PJN07242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN07242">
        <property type="protein sequence ID" value="PJN07242"/>
        <property type="gene ID" value="CG723_35220"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.102.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017941">
        <property type="entry name" value="Rieske_2Fe-2S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036922">
        <property type="entry name" value="Rieske_2Fe-2S_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00355">
        <property type="entry name" value="Rieske"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50022">
        <property type="entry name" value="SSF50022"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51296">
        <property type="entry name" value="RIESKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014793048" evidence="5">
        <location>
            <begin position="34"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="domain" description="Rieske" evidence="6">
        <location>
            <begin position="59"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="32"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PJN07242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="152" mass="14934" checksum="25DE8279AC86027A" modified="2018-04-25" version="1">MTASHESVSAPTRRTVVAAVGAAGIAAALTACGSSDDSSSSEPAGNAADDGAAKDGAGKELAKTADIPVGGGKIFGDAGVVVTQPKKGEFKAFTNICTHKQCPVTAIEGGTINCPCHGSKFSIEDGSVKHPPAAQPLAAKEITVSGDSITLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JKB5</accession>
    <name>A0A2M9JKB5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_34220</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000021">
        <property type="protein sequence ID" value="PJN07311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN07311">
        <property type="protein sequence ID" value="PJN07311"/>
        <property type="gene ID" value="CG723_34220"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="122"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN07311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="179" mass="19034" checksum="5DA0C6CFDB697B6F" modified="2018-04-25" version="1">MADHATHDAQARASLHLLVRDIERVRRQVDALRTLSAQLGNVYRPRRSGPSAGFVVYGRAPAPTVRLAQELRDSVETLVTAAVDFDRSLGFSWDAVGSALGVTKQAVHRRYGARRAAAQAAAEAERATETAGTRPPVPIGTATIPSVPAARSMPTQPTAGSPVLREDPRPTAFPGPRNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JKP9</accession>
    <name>A0A2M9JKP9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">5,10-methylene tetrahydromethanopterin reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_33680</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000020">
        <property type="protein sequence ID" value="PJN07450.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN07450">
        <property type="protein sequence ID" value="PJN07450"/>
        <property type="gene ID" value="CG723_33680"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011251">
        <property type="entry name" value="Luciferase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036661">
        <property type="entry name" value="Luciferase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00296">
        <property type="entry name" value="Bac_luciferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51679">
        <property type="entry name" value="SSF51679"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bac_luciferase" evidence="1">
        <location>
            <begin position="19"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN07450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="350" mass="36451" checksum="604796E2594245AA" modified="2018-04-25" version="1">MSGAEQPPLRVGIRIPPCERADRIVETVRRAEELGFSDAWFPDSQLLWRDVFTTLTAAALGTERIGLGTAVTNLVTRHPAVVASAARSVAELAPGRFTLGLGVGNSSVGPVGLKQSTNSAMRAGIAQLRALLDGADWDFEGPAGTVRSRLRDPRPDVPLHLAASGPRNLRLAGEVADGVVLLSGVSTRTLAGATARVREGAEAAGRDAAALPLTVSAYCAVTDDIEAAARRLKPICASIAHNGGAPFLALAGIHVDVPDVPDINAGVYPDLVHAEDWDAAVKITSEWVGDEAALRFAEEFCLVGTAEQIAGRLRALCADGVSGVFLQHVGSYDPPTELIETVGASVLPAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JKR2</accession>
    <name>A0A2M9JKR2_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">5-oxoprolinase subunit A</fullName>
            <shortName evidence="1">5-OPase subunit A</shortName>
            <ecNumber evidence="1">3.5.2.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">5-oxoprolinase (ATP-hydrolyzing) subunit A</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">pxpA</name>
        <name evidence="2" type="ORF">CG723_34520</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the cleavage of 5-oxoproline to form L-glutamate coupled to the hydrolysis of ATP to ADP and inorganic phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>5-oxo-L-proline + ATP + 2 H2O = ADP + H(+) + L-glutamate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:10348"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58402"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.5.2.9"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">Forms a complex composed of PxpA, PxpB and PxpC.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the LamB/PxpA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.2.9" evidence="1"/>
    <dbReference type="EMBL" id="NNBL01000021">
        <property type="protein sequence ID" value="PJN07367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN07367">
        <property type="protein sequence ID" value="PJN07367"/>
        <property type="gene ID" value="CG723_34520"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017168">
        <property type="term" value="F:5-oxoprolinase (ATP-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00691">
        <property type="entry name" value="PxpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005501">
        <property type="entry name" value="LamB/YcsF/PxpA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30292">
        <property type="entry name" value="PTHR30292"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03746">
        <property type="entry name" value="LamB_YcsF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="SSF88713"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN07367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="263" mass="27732" checksum="70D35DED794684C4" modified="2018-04-25" version="1">MTSLTAQAPPAAVTIDLNADLGEGFGRWRLTDDEQLLSVVTSANVACGFHAGDAATMRRVCDLASERGVRVGAQVSYRDLAGFGRRAMDVPPDELAAEVAYQIGALEVFTRAAGTRVAYVKPHGALYNRVVHDEEQARAVVDGVRLADDTLPVLGLPGSHLLKVADEAGLPVVTEAFADRAYTARGTLVPRGSEGAVVTDPESVVERSVGLARFGTVTSHDGEQISVRARSLCLHGDTSGAVDLARRVRAQLESAGVRVEAFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-06-02" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JLH6</accession>
    <name>A0A2M9JLH6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_32185</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000018">
        <property type="protein sequence ID" value="PJN07731.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN07731">
        <property type="protein sequence ID" value="PJN07731"/>
        <property type="gene ID" value="CG723_32185"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043737">
        <property type="entry name" value="DUF5682"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008912">
        <property type="entry name" value="Uncharacterised_CoxE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18934">
        <property type="entry name" value="DUF5682"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05762">
        <property type="entry name" value="VWA_CoxE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="SSF53300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="124"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="247"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="817"/>
            <end position="870"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="128"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="820"/>
            <end position="836"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN07731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="1237" mass="128846" checksum="3C58D98C477592F0" modified="2018-04-25" version="1">MTTDAGVAIGALTHPDGPYLIGVRHHAPSLAAVVPRLLDEAAPDVLLVELPAETQELLPWLAHEETVAPVALAAVLDREGESGPAFYPFADFSPELAALRWAARNGVPVVACDLPLAERAWREPQVPRPAARAEHPRRPGGGDAPRLGDAVRGRLTGRDGDDLWDRLVEAPAPGATPQALRRAALLTGWALRRDAADGPGVDPLDLARERWMRARLREAAREGRRVAALIGAFHAPALSAGALRDEAQEEPIAGPSDRTPAESQARVTAEPHTEAPAAPTPAVSLIPYTYALLDARSGYPAGIRDPEWQHQVLESAGDPAAVGETALHCAVRVTSELRAEGHPSGPADAREIRRVAGDLASLRGLPAPGRSEFVEAVQTVLAQGEPLGRGRAVARALERVLVGERTGRAAPGAPRGGLAPAVETELASLGLPGPASGGQEKELRLDPLRSDLDRKREVLLRRLALCGIPYAQETSVGGAGGADALTTRWTVRWTPATAAVLTTATTRGVTPAQVAEGVLRARVRAAHAEGGPTAAQALAVLGEAARCALPALAAEALAEVTTVLPAIGTLPELLTGLALTDRLSAGHIAGLATTDPVTDPAASPAPATPWHHAPADCADLLTVAAVRSLDGLTGSEDPEDARALVELARRADVFGGMRLADSLARLADGGTPLMRGAAAAVRVLLGHTPATALGVRAASWVDTAGGPGTRAELTARLTGLLTAAGSLLETAPEALAPLLDRVGELPDNPFLERLPALRGGFDTLSPAARDRLLTVIEERIDGTLDADLPPDTDARTLAAWTAADLAAREALAALDLLPPTPDGLVPPTPNTLPPTTPDTSDRPHAASPSAATYAPVRTPASVSPPGGPRIAPAERWRLVLGRRGDQLPQGIAPLATALDELYGRGRGEGARGDLPGGAGGRVGREAPYPGVREWAEELTTLFGPGIREEVLAAAATRGRTDVVSALDPEAVRPSVELLRTVLQHAGGLPEAKLAALRPLVRRLVDELTRALATRMRPALTGAATARPTRRPGGRLDLARTLRANLATARRTDDGRIHVIPERPVFHGRAQRSADWRLIVLTDVSGSMEASTIWSALTASVLAGVPALSTHFLAFSTTVLDLTEHVHDPLALLLEARVGGGTHIAAGLRHARTLVTAPSRTLVVVVSDFEEGYPVGGMLAEVRELVGAGCHVLGCASLDDAGRPRYSTGIAGQLVAAGMPVAALSPLELARWVGEKIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-05-25" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JMA3</accession>
    <name>A0A2M9JMA3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">LacI family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CG723_30420</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000016">
        <property type="protein sequence ID" value="PJN08011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08011">
        <property type="protein sequence ID" value="PJN08011"/>
        <property type="gene ID" value="CG723_30420"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01392">
        <property type="entry name" value="HTH_LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000843">
        <property type="entry name" value="HTH_LacI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046335">
        <property type="entry name" value="LacI/GalR-like_sensor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00356">
        <property type="entry name" value="LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13377">
        <property type="entry name" value="Peripla_BP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00354">
        <property type="entry name" value="HTH_LACI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50932">
        <property type="entry name" value="HTH_LACI_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH lacI-type" evidence="4">
        <location>
            <begin position="5"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PJN08011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="339" mass="35705" checksum="2DD46857AF8AF580" modified="2018-04-25" version="1">MARKPTIADVAQRAGVSRATVSFALNDRPGIAGETKARVLAAAADLGWTPSHQARGLSLGKAGAFGLVLAREAEQIGADPFFPAFIAGVEAVIGQRGDGLMVHVTTPEHEQGVYERLAAQRQVDGVLLTDLRRDDPRPPLMRELGLPAVVVGQPEWGGGLTAVSLDDEPAYADAIRRLADLGHRRIAHVEGPQELRHAHRRRTAWERTLGTLGLPAGPVLPGGFSPEGGARATRELLTLPEPPTAIVYGNDLAAMAGLSVAQELGVRVPDQLSVVGYDDAPLTRYSYPPLASARADARGWGEAAARALDAVIALGTAAHVELPPAQFVPRASIGPVPRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JMG3</accession>
    <name>A0A2M9JMG3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">GntR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CG723_30730</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000016">
        <property type="protein sequence ID" value="PJN08059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08059">
        <property type="protein sequence ID" value="PJN08059"/>
        <property type="gene ID" value="CG723_30730"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07377">
        <property type="entry name" value="WHTH_GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.530">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011711">
        <property type="entry name" value="GntR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008920">
        <property type="entry name" value="TF_FadR/GntR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07729">
        <property type="entry name" value="FCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
        <property type="entry name" value="GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00895">
        <property type="entry name" value="FCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00345">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48008">
        <property type="entry name" value="SSF48008"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50949">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH gntR-type" evidence="4">
        <location>
            <begin position="15"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PJN08059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="223" mass="24595" checksum="60D2D2D01DA8E6C6" modified="2018-04-25" version="1">MQHVATEPAVGGEELSLAERAYRAIRDQLVMLDIRPGAPINEDQLAQSLGVGRTPVREALKRLQYERLVATYPRRGTFATDVNITDLAHISEVRLELEPLAAARAARRATAEDRAALTVVRRELAGVDPRQGNAAELMHLDLKVHRAVYAATHNPYLEDTLIRHDNLATRIWCLFIDRLADMAGHVEEHGPLIDAIVAGEADAAAQIARAHVEGFERAVRDAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JMZ5</accession>
    <name>A0A2M9JMZ5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Peptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CG723_29970</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000015">
        <property type="protein sequence ID" value="PJN08229.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08229">
        <property type="protein sequence ID" value="PJN08229"/>
        <property type="gene ID" value="CG723_29970"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013595">
        <property type="entry name" value="Pept_S33_TAP-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08386">
        <property type="entry name" value="Abhydrolase_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015006588" evidence="3">
        <location>
            <begin position="21"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="domain" description="Abhydrolase_4" evidence="4">
        <location>
            <begin position="426"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="27"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="386"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="386"/>
            <end position="400"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PJN08229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="532" mass="55680" checksum="7A88F6BE0D685612" modified="2018-04-25" version="1">MSRHVRSFALLAAGLLVAGAAAGCGGPGDKAGHGEGKGQTQPPRSSPPSPSSPPRSGKAVPGTLPRLPAALTSQRLDWGRCKATDDGPAPGSDWQCATLKAPLDYAKPDGETIGVALIRARSTSGSGRSGSLLFNFGGPGGSGVSMLPAFAPDYAKLRERYDLVSFDPRGVGASEGVRCRDDKAIRTAESVDLTPDSPAEERAYFHDAADFGAGCARQAGKLLGHVSTDETARDMDLARQALGDDKLHYMGVSYGTQLGGVYAHLFPGKVGRLVLDAVVDPAADTVGHAENQTRGFQRALDNYLKSTGQDPDQGSRKIAALLKRVDAKPLPASGSRVLNQSLATIGITVTLYSKNSWPALTRGLEAAEQGDGTALLALADAYNERSPSGHYSSQSHSQRAISCLDDKERPTPKEARKRLASFRGISPVFGEFMAWDTAGWCHDWPVPGQYETPEVSAPGAAPILVVGNTGDPATPYEGARRMADELGKGVGVELTWKGEGHGAYGSGSGCVDSTVNGYLLEGRIPRDGKVCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-09-29" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JNM6</accession>
    <name>A0A2M9JNM6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Phenylacetic acid degradation protein PaaN</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">paaN</name>
        <name evidence="3" type="ORF">CG723_29280</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000014">
        <property type="protein sequence ID" value="PJN08466.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08466">
        <property type="protein sequence ID" value="PJN08466"/>
        <property type="gene ID" value="CG723_29280"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016620">
        <property type="term" value="F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011975">
        <property type="entry name" value="PaaN_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="SSF53720"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02288">
        <property type="entry name" value="PaaN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldedh" evidence="2">
        <location>
            <begin position="95"/>
            <end position="540"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN08466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="568" mass="60314" checksum="94A71563B98B8853" modified="2018-04-25" version="1">MAAEVTAHDLIAKHRPTLDQALEAIRTRAYWSPHPEHPKAYGEHGSLSMPEGKAAFDALSGTRIDLGQPGTDDWVGGETSPYGVELGVTYPHPDLDVLLPAMRAGMRAWREAGAEARAAVCLEILARISARTHEFAHAVMHTSGQAFMMAFQAGGPHAQDRGLEAVAYAYVEQVRTPDAAEWTKPQGKRDPLVLGKQFTPVGRGIALLIGCNTFPTWNGYPGLFASLATGNPVLVKPHPRAVLPLALTVQVAREVLAESGFDPNLVALAAEKPGEGIAKTIALRPEIKIIDYTGSTAFGDWLETHARQAQVYTEKAGVNTVVIDSTDRYKGMLANLAFSLSLYSGQMCTTPQNLLIPRDGIATDEGLKTYDEVVTDIAAAVGGLLGDDARANALLGALVNPDVKSRLEAASGLGEVALASREISNPEFPGAVVRTPMIVKQDGARKFWDGADSDSAYLSECFGPVSFAVAVDSTADALDLLRRTVRDKGAMTVGAYTTSDEVAEGVEEVCLEECAQLSINLTGGVYVNQTAAFSDFHGSGGNPAANAALCDGAFVANRFRVVEVRTEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-09-29" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JNQ3</accession>
    <name>A0A2M9JNQ3_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Endo/exonuclease/phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_29035</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000014">
        <property type="protein sequence ID" value="PJN08501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08501">
        <property type="protein sequence ID" value="PJN08501"/>
        <property type="gene ID" value="CG723_29035"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03372">
        <property type="entry name" value="Exo_endo_phos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="SSF56219"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="17"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="42"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="domain" description="Endo/exonuclease/phosphatase" evidence="2">
        <location>
            <begin position="80"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN08501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="297" mass="31999" checksum="072D5E2A96828F69" modified="2018-04-25" version="1">MGCRIADVDGVTPVPQLLAFLPWLLAPTGAALLLTALARWRIGMVWGVAALGALAWYIEPYGKDVDASGPPVADVRVLSSNVQFGRGTESLVGAVRRERPGLVFVEECDYRCQDILRRELPRADFPYRQAVEAGGSEGSVILSRYPLKAAAGVPGTMGMPGAVADVKGHDVRLQLAHPMPPLPQQVGLWRSELGELRDFAAAGRSQPTILAGDFNATQDHAAFRRILDAGLHDSARLAGKSRAPSWPSRVRPPLGTQIDHVLVSEDFSAHSARFVELADTDHRALLVDLTMHRPAAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-09-29" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JP62</accession>
    <name>A0A2M9JP62_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Enoyl-CoA hydratase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_26550</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the enoyl-CoA hydratase/isomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000012">
        <property type="protein sequence ID" value="PJN08661.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08661">
        <property type="protein sequence ID" value="PJN08661"/>
        <property type="gene ID" value="CG723_26550"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.12.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014748">
        <property type="entry name" value="Enoyl-CoA_hydra_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="241"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="248"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN08661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="262" mass="27639" checksum="A64181A0AF1DEE8B" modified="2018-04-25" version="1">MSATIECTTTDAVTWITLNRPEAMNALTWDQREEIIGILNSASADPDVRAVVITATGRGFCAGADLRGAPASGPRVPGDVARTIRLGAQRLIAAVMDCEKPVVAAVNGTAAGIGAHLAFACDLVLAAESARFIEVFVRRGLVPDGGGAYLLPRLIGPQRAKELMFFGDALSSADAERLGLVNRTVPDGELRKTAQEWAARLASGPTRAIAMTKQLVNASLESDRATAFAAEATAQEINMTTADAQEGVASFKERRDPTYKGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-06-02" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JPG3</accession>
    <name>A0A2M9JPG3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_27225</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000012">
        <property type="protein sequence ID" value="PJN08773.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08773">
        <property type="protein sequence ID" value="PJN08773"/>
        <property type="gene ID" value="CG723_27225"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002372">
        <property type="entry name" value="PQQ_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_supfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13360">
        <property type="entry name" value="PQQ_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="SSF50998"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="125"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="146"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="76"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="97"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="177"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN08773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="592" mass="62246" checksum="3985127585F13B05" modified="2018-04-25" version="1">MTQPPNQPPQGGFGAPQDPQQPPGQPPQPPGQPPQTPPAPQPGYGYPQQPGPYGQPPQGGPYGQPQQPGPYGQPQQQPGPYGQQPQYGYPQQQPQYGYPQQQPPFPGGPAGPGGGKNPFKGRTGIIVAAAVAVVVIAGGVVWAVVGGGDDKKKDPVADKSQDPKPTGSAPVDPGDGSGDGRDGKEDLNAGRQAGESKVLWYKTAPKAPGDGADAPGMWVTDTLAAKAVYNELVAYNISDGKPSWPTIKLPQKICGASVQKSDDDKVAIAYMSGVTDRAKCNQVQQIDLKTGKKDWEKKIPEGDLFDGTGSGVELTYAGSTLMVGRQMSGLGLSVSDGKQLFEKKKYGAACFPGAFAGGERLLAVSSCGASTDKEHDEIQELDPATGKAKWTKPFPKGWKVARAYSVSPVVLYLTNEDKKQWNITTLKNGSSAVRSEVSVDEDFAPECGWAILDRDLQGCTGVAADTNTLYLPTKATSGSANEVVAISLENGKERWRAKSPVAQNMLPLKTEGGAVIAYVNASYDAGGRVVSIATAGSHTPKTLLQNPAGTAQIENGFYSKAVDYVDGRFYISTTRLSGTAKGEEKLMLAYGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JPL4</accession>
    <name>A0A2M9JPL4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Dioxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CG723_26930</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CB01635</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DODA-type extradiol aromatic ring-opening dioxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000012">
        <property type="protein sequence ID" value="PJN08814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08814">
        <property type="protein sequence ID" value="PJN08814"/>
        <property type="gene ID" value="CG723_26930"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008198">
        <property type="term" value="F:ferrous iron binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016701">
        <property type="term" value="F:oxidoreductase activity, acting on single donors with incorporation of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006725">
        <property type="term" value="P:cellular aromatic compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07363">
        <property type="entry name" value="45_DOPA_Dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014436">
        <property type="entry name" value="Extradiol_dOase_DODA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004183">
        <property type="entry name" value="Xdiol_dOase_suB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02900">
        <property type="entry name" value="LigB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006157">
        <property type="entry name" value="Doxgns_DODA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="LigB" evidence="5">
        <location>
            <begin position="3"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PJN08814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="253" mass="27348" checksum="1FCE29BF8E3C360C" modified="2018-04-25" version="1">MPALYLSHGAPPLADDDLWTGQLAAWSAELPRPRAVLMVSAHWEEAPLALGATETVPLVYDFWGFPEHYYQVRYEAPGAPELADSVRKLLHGPGTPVQDIPDRGLDHGAYVPLVEMYPGADIPVLQISMPTLDPQKLMGIGRKLAPLRDEGVLIVGSGFFTHNLAALRQGGIPAWSAEFDDWGHRALESGDVDALLDFTHKSPAGQLAHPRTEHFAPLFVAMGAADASGGLDGQRSVIDGFWMGLAKRSVQFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JPR2</accession>
    <name>A0A2M9JPR2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CG723_25540</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CB01635</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000011">
        <property type="protein sequence ID" value="PJN08862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08862">
        <property type="protein sequence ID" value="PJN08862"/>
        <property type="gene ID" value="CG723_25540"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032688">
        <property type="entry name" value="ABC2_membrane_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12679">
        <property type="entry name" value="ABC2_membrane_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="61"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="104"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="150"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="179"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="230"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PJN08862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="256" mass="27491" checksum="64131ABFA5782BC7" modified="2018-04-25" version="1">MATTQVLRSEWTKIRSVASTVWTLGLAAVLTIALGVLISILSKNEFKNMGLKERLSFDPTFISFAGMSLGQLAMIVFGVLVVSNEYSTGMIRTSLAAVPQRGTFLFSKVAVATVLAFVVGLATSFIAFFLGQAVLGEYRAQIGDPGVLRAVIGGGLYMTLIAMFSMGVASMLRSPMLSLGILMPFFFLISNILGNVSATKKIGRYLPDQAGSKIMQVVTPIDDDTPYGPWGGLGIMVIWVVLALIFGYVLLKKRDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JPT5</accession>
    <name>A0A2M9JPT5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_26825</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000012">
        <property type="protein sequence ID" value="PJN08807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08807">
        <property type="protein sequence ID" value="PJN08807"/>
        <property type="gene ID" value="CG723_26825"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="222"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="257"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="350"/>
            <end position="369"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN08807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="383" mass="41104" checksum="A2D8546950A35B04" modified="2018-04-25" version="1">MWRYVWAPPARATKPAAAPPRNRAYLHDRLVALPLLAAIAFSGLGFTATSLRDDSATIRTHIAPALRDLADARISLRIAQREAEVSLGAGDAVELSGLSPRYGSRITGAAQDLSQVSRSGALTAAERQELDVVSGLVDGYERWIAWAQTNVSDGSLYRAGLSYAQSMLCSPDPHDPYEPATGRYAPYPRCAPVTGSEATTVVDRISDLERALRHRLEARATLGPAAVTAAAVSAVAFVLLTAGLWRTLRFLRIRFRILASPPLLAAALPLLAVPVIALSGLYAHAAQEDTVPIARRLYAVTSPSTEVIFEERRTDPLDPHHHRAIVTLADSMDDVLDNRRLAGLDAVAPWAAPVGLLVAGVIGATLHAYRREYLLVGRPGTAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-05-25" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JQ16</accession>
    <name>A0A2M9JQ16_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glucosamine-6-phosphate deaminase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_26175</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000011">
        <property type="protein sequence ID" value="PJN08972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08972">
        <property type="protein sequence ID" value="PJN08972"/>
        <property type="gene ID" value="CG723_26175"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097367">
        <property type="term" value="F:carbohydrate derivative binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901135">
        <property type="term" value="P:carbohydrate derivative metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05008">
        <property type="entry name" value="SIS_GlmS_GlmD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05009">
        <property type="entry name" value="SIS_GlmS_GlmD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035466">
        <property type="entry name" value="GlmS/AgaS_SIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035490">
        <property type="entry name" value="GlmS/FrlB_SIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001347">
        <property type="entry name" value="SIS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046348">
        <property type="entry name" value="SIS_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01380">
        <property type="entry name" value="SIS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53697">
        <property type="entry name" value="SSF53697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51464">
        <property type="entry name" value="SIS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="SIS" evidence="2">
        <location>
            <begin position="42"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="domain" description="SIS" evidence="2">
        <location>
            <begin position="206"/>
            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN08972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="356" mass="37665" checksum="330AB67ED7273D95" modified="2018-04-25" version="1">MTATPSAPKSEQPGRIMAREMAEQPEVLRRLLDTGAPRIHEVARRVAAQSPRFVLLTARGTSDNAALYAKYLLEIRLGMPCGLASMSTTTAYGARPDLRDVLAVTVSQSGGSPDLVASTKAARAAGAITLAVTNNPDSPLAAVSEHHIDIMAGPEKALPATKTYTASLLALYLFVEGLRGGDGSPAQVLPGLAQQLLARQDEVRALASRYRFADRMVITSRGYGYPTAKEAALKLMETSYIPALSYSGADLLHGPLAMVDNISPVIAVVTDGKGGLMLQPVLDRLRGRGADLVVIGPKAQVDRASAGFVLPTQGVAEEVQPVLEIIPLQFLAYEVTIARGQDPDAPRALAKVTETH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JQQ7</accession>
    <name>A0A2M9JQQ7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Sugar ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CG723_24750</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000010">
        <property type="protein sequence ID" value="PJN09127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN09127">
        <property type="protein sequence ID" value="PJN09127"/>
        <property type="gene ID" value="CG723_24750"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008643">
        <property type="term" value="P:carbohydrate transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03301">
        <property type="entry name" value="ABC_MalK_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015855">
        <property type="entry name" value="ABC_transpr_MalK-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008995">
        <property type="entry name" value="Mo/tungstate-bd_C_term_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040582">
        <property type="entry name" value="OB_MalK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17912">
        <property type="entry name" value="OB_MalK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50331">
        <property type="entry name" value="SSF50331"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="4"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="38"/>
            <end position="45"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PJN09127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="379" mass="40621" checksum="72742FE6908FA169" modified="2018-04-25" version="1">MATVSFDKATRIYPGSTKPAVDGLEIEIEDGEFLVLVGPSGCGKSTSLRMLAGLEDVNGGAIRIGDRDVTHLPPKDRDIAMVFQNYALYPHMSVADNMGFALKIAGVNKAEIRQKVEEAAKILDLSEYLDRKPKALSGGQRQRVAMGRAIVREPQVFLMDEPLSNLDAKLRVSTRTQIASLQRRLGITTVYVTHDQVEAMTMGDRVAVLKDGLLQQVDTPRNMYDRPANLFVAGFIGSPAMNLVEVPITDGGVKFGNSVVPVNREALKAASDAGDRTVTVGVRPEHFDIVEAGGGEAAKSLSKDTEDAPAGLAVSVNVVEELGADGYVYGTAQVGGEAKDLVVRVNGRQVPEKGTQLHVVPRPGETHVFSSSTGERLTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JR11</accession>
    <name>A0A2M9JR11_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">TetR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CG723_23510</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000009">
        <property type="protein sequence ID" value="PJN09316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN09316">
        <property type="protein sequence ID" value="PJN09316"/>
        <property type="gene ID" value="CG723_23510"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039538">
        <property type="entry name" value="BetI_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13977">
        <property type="entry name" value="TetR_C_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0678">Repressor</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="3">
        <location>
            <begin position="11"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="2">
        <location>
            <begin position="34"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PJN09316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="193" mass="21798" checksum="BB56391D36019ED5" modified="2018-04-25" version="1">MAKRGPYEKGEAKRAEILHAALEIFASEGYRGTSLRKVAAKCNLSLPGLMHYFDSKEDLLTQVLRMRDEEARVRHAERADPKSYREIIREGASTPGLVELFVSMAAAASDPGHPAHALFAERYPTMRERTADYLRRRMDEGTLRSDIPPERLAVLFLALADGIQLQWLIDRSTDMEQPIDDVMSLLETEPDKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JRG1</accession>
    <name>A0A2M9JRG1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_22120</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000008">
        <property type="protein sequence ID" value="PJN09471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN09471">
        <property type="protein sequence ID" value="PJN09471"/>
        <property type="gene ID" value="CG723_22120"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007136">
        <property type="entry name" value="DUF347"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03988">
        <property type="entry name" value="DUF347"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="61"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="90"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="135"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="175"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="200"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="227"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="258"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN09471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="294" mass="31448" checksum="7E31825C64449CFF" modified="2018-04-25" version="1">MENPEILTDLDVASTHESAASRTESVMKKLPEVTLAFWIMKIAATTLGETAGDLFAQTLKLGYFLTTIALFLTFVVTLVVQLRSSRYNPFFYWTVILSTSMAGTTMSDFMNRDASAKFLSNGATSLGWGPQGLGLGYPTGAAILISILLVIFAVWKVSGMTFQIRDIVTFRGEALFWAAILVSNTLGTSMGDFLSDSSGLGYLGGALLVSGALAVLLALMKVPVVPNVLLFWIAFVLTRPLGATAGDFLTKPVAKGGMNLGTVGSSAVLLVILFSLMAYAHMQEKKAVTLCEQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JRL9</accession>
    <name>A0A2M9JRL9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CG723_21905</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000008">
        <property type="protein sequence ID" value="PJN09437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN09437">
        <property type="protein sequence ID" value="PJN09437"/>
        <property type="gene ID" value="CG723_21905"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PJN09437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="68" mass="7810" checksum="8AA6A092410ECC98" modified="2018-04-25" version="1">MGLAGLPGREWMIRDSKGRKYSYDSEQEAIEELPEHGEGATVWTREVYRVLFVTRSVDGWQQVPTPRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JRQ6</accession>
    <name>A0A2M9JRQ6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Sugar ABC transporter substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_22655</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000008">
        <property type="protein sequence ID" value="PJN09544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN09544">
        <property type="protein sequence ID" value="PJN09544"/>
        <property type="gene ID" value="CG723_22655"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006059">
        <property type="entry name" value="SBP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01547">
        <property type="entry name" value="SBP_bac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014618172" evidence="1">
        <location>
            <begin position="32"/>
            <end position="551"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN09544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="551" mass="61648" checksum="0EAA5097E85D4008" modified="2018-04-25" version="1">MTNTGRLSRRSLLAAAGFAGLAVLTGCGSGDDGGDSKDLSKKQNGAMKKYNAGEQFKATKALSFSVLHNNNPTYPTKKSWLFWKEVTKRTGITLQPVDVPLSDYEKKRSLLIGSGDAPFLIPKTYHPSEVAFVSSGAILPVSEYVHLMPNFQDKVKRWKLEPELDSIRQSDGKYYLLPGLHEKPKSGYSLSFRTDVLDRIGVSLPSTWDEVYDVLKAIKAEYPDSYPLSDRWSTNTVFPAAALLSYLGQAYGVRAGWTYENITFDAKTQKFVFTGATDEFRQVIEYLRKLVTEKLMDPESFTQTDDNAVKKLLAEKSFAISANPQELVQKYRYNLERQVKGAKIEMIPVPIGPAGEVVLGGIRLENGLMISSKALKNDNFVALMQFTDWLFYSDEGQAFCKWGVEGVTYTGSGGQYKLKPGISLMGSDPKAPKDLQKDYGFFNGVFTYGGSWQLVSSSFSPDEKKFQDVMASRKQTPIAPAHPLLSAEQEQASLWETPLTDHMNQNTLKFALGKRPLSEWDDYVTELKAKNMQQLVDLHNKAYERYKKDNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JRT0</accession>
    <name>A0A2M9JRT0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Short-chain dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CG723_22905</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000008">
        <property type="protein sequence ID" value="PJN09586.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN09586">
        <property type="protein sequence ID" value="PJN09586"/>
        <property type="gene ID" value="CG723_22905"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PJN09586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="261" mass="26718" checksum="624722368E3F527E" modified="2018-04-25" version="1">MTTTPSESLEGRRALVTGGTKGTGAAIARRLSQAGATVLVTARTRPADVEEKTFVAADLSSPDGAGHVVAEVEARVGGVDILVHTLGGSQAPAGGFAMLGEDDWARELNTNLLAAVRLDRGLLPGMITAGKGAVVHVTSIQRRMPLWNGTLGYAAAKAALTTYSKGLANEVAPHGVRVNTVSPGFIQTTAADNLVTRIAAEAGITQGAALDRLMDSLGGIPLGRPNRPEEVAELVAFLVSDRASSIVGTEHVIDGGTTPTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JRW6</accession>
    <name>A0A2M9JRW6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CG723_22975</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000008">
        <property type="protein sequence ID" value="PJN09598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN09598">
        <property type="protein sequence ID" value="PJN09598"/>
        <property type="gene ID" value="CG723_22975"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PJN09598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="65" mass="7437" checksum="040179CF4FC88ADD" modified="2018-04-25" version="1">MQRWIDTAGRPRGEDFTSAGFEALIPEEFSAHVWIMEGMLERAGFDIISRAAPHPTHAEFHSLRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JS31</accession>
    <name>A0A2M9JS31_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CG723_20940</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CB01635</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GPN-loop GTPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000007">
        <property type="protein sequence ID" value="PJN09679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_054239772.1">
        <property type="nucleotide sequence ID" value="NZ_NNBL01000007.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN09679">
        <property type="protein sequence ID" value="PJN09679"/>
        <property type="gene ID" value="CG723_20940"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004130">
        <property type="entry name" value="Gpn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03029">
        <property type="entry name" value="ATP_bind_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PJN09679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="193" mass="20716" checksum="3D2934C0E65BBCC4" modified="2018-04-25" version="1">MDFASSSGGPSRSTTSAKIVVAGGFGVGKTTFVGAVSEINPLRTEAVMTSASAGIDDLTHTGDKTTTTVAMDFGRITLDQDLILYLFGTPGQDRFWFMWDDLVRGAIGAIVLVDTRRLADCFPAVDYFENSGLPFVVALNGFDGSQPYQPDEVREALQIGPDTPIITTDARHRADAKSALITLVEHALMARLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JSC2</accession>
    <name>A0A2M9JSC2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Aspartate aminotransferase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_21435</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000007">
        <property type="protein sequence ID" value="PJN09764.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN09764">
        <property type="protein sequence ID" value="PJN09764"/>
        <property type="gene ID" value="CG723_21435"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044249">
        <property type="term" value="P:cellular biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="CDD" id="cd00610">
        <property type="entry name" value="OAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005814">
        <property type="entry name" value="Aminotrans_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00202">
        <property type="entry name" value="Aminotran_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00600">
        <property type="entry name" value="AA_TRANSFER_CLASS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="1 2" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN09764.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="459" mass="50715" checksum="8ED135351DA3AAB8" modified="2018-04-25" version="1">MGNPIAVSKDLSRTAYDHLWMHFTRMSSYENAPVPTIVRGEGTYIYDDQGKKYLDGLSGLFVVQAGHGRRELAEVAAKQATELAFFPVWSYAHPKAVELAERLAHYAPGDLNKVFFSTGGGEAVETAWKLAKQYHKLNGNHTKYKVISRAVAYHGTPQGALSITGLPALKAPFEPLVPGAHKVPNTNIYRAPIHGDDPEAFGRWAADQIEQEILFEGPETVAAVFLEPVQNAGGCFPPPPGYFQRVREICDQYDVLLVSDEVICAFGRLGTMFACDKFGYIPDIITCAKGMTSGYSPIGATIVSDRIAAPFYKGDNTFLHGYTFGGHPVSSAVAIANLDLFEREGLNQHVLDNEANFLKTLQKLHDLPIVGDVRGNGFFYGIELVKDKDTKESFTDEESERVLYGFVSKKLYEYGLYCRADDRGDPVIQLSPPLISDQSTFDEIEGIIRQVLTEAWSKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JSI8</accession>
    <name>A0A2M9JSI8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_21805</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000007">
        <property type="protein sequence ID" value="PJN09830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN09830">
        <property type="protein sequence ID" value="PJN09830"/>
        <property type="gene ID" value="CG723_21805"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002372">
        <property type="entry name" value="PQQ_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_supfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13360">
        <property type="entry name" value="PQQ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="SSF50998"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="25"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="86"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN09830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="487" mass="52468" checksum="FB57B23B11AEF7DC" modified="2018-04-25" version="1">MSFGPPPSPFTQSQRAAEERRSRRVRAWACAVLALVAVAGAGGWFLIAGSPDGGDPGMGNKAAAVQQAPDDIRETVEKRPRGTAGHLVASMQDRVEPNQDQETPGTWARDKVLVKGNNDALEAVDIDSGDEAWRHDLTGSICAWTQHVTVDGRTAIAFKDKEKDGACNQLALFDLDSGKKLWQVVIPWKESALGNFPDVTMAKGVVSSAWARGSAGYDMKSGKRLWERKGIANCREGGFAGGKALLLRLDCTTSDYEPTTKIAKLDPRSGKEKWRYDVAESVGLVFIISSEPAVLAVAAGEDDISDLISLDERGKYRATVRLDGGHYEVDCDSGVTYSAVDDCSDIVVGGGQVFITSGEDVDGSNHRSNRIVSFDLGTGKPVVKFEAGPDQMIHPVRMSGGQLLAFRDGTDNYAPFSLVSLDPRTGKEKVFFYFTVLNEAVSLTYTKFSDVVVENGRIFFGSNMVRGESIKGKPVPEWLAFGVGSAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JSJ1</accession>
    <name>A0A2M9JSJ1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CG723_20870</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000007">
        <property type="protein sequence ID" value="PJN09849.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN09849">
        <property type="protein sequence ID" value="PJN09849"/>
        <property type="gene ID" value="CG723_20870"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039538">
        <property type="entry name" value="BetI_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13977">
        <property type="entry name" value="TetR_C_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0678">Repressor</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="3">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="2">
        <location>
            <begin position="13"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PJN09849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="184" mass="20561" checksum="D92900D6E0E3D087" modified="2018-04-25" version="1">MEMIAERGLEKLTMAALGREVGMSSGHLLYYFGSKDELLLRTLEWSEGRLGAERARLLSGGGTVRERLDAYVDLYVPDAQGDPHWTLWLEVWNRSQNAEADGDARERQAAIELAWHRDLVALLAEGTSRGELPPLDPDRFASRLRALLDGFSIHVAIGLRGTDRAQILSHVREFLDEALVKNPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-09-29" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JSM1</accession>
    <name>A0A2M9JSM1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CG723_19305</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CB01635</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000006">
        <property type="protein sequence ID" value="PJN09891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN09891">
        <property type="protein sequence ID" value="PJN09891"/>
        <property type="gene ID" value="CG723_19305"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004776">
        <property type="entry name" value="Mem_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03547">
        <property type="entry name" value="Mem_trans"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="6"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="65"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="97"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="123"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="165"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="192"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="223"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="254"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="287"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PJN09891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="307" mass="31466" checksum="250A73FD9879D71E" modified="2018-04-25" version="1">MAGVLNGFAVIAVVIAVGFLIGKRGYLGDNGREVLTKLAFHVATPALLFTTLAKADLSVILSPRLLVTALSTAAAAGVFIAVGVARRWGVGRTTIGALCSSYVNSGNLGIPIAVYVLGDASLVAPVLLFQQIVVTPIAMTVLDLSEAGETRSLWQRIVTPLRNPIAVGALAGVIVAATGWTVPGPVFNPVDLIGKMSVPVVLLAYGISLCGSSLPARRGSDRVPVLLSVALKSVAQPAVAWVLAAGVFGLRGASLLDVVVTSALPAAQNLFTYASRYNVAERLARESILLSTLASVPALVVVAALLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JT00</accession>
    <name>A0A2M9JT00_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CG723_19950</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CB01635</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="NNBL01000006">
        <property type="protein sequence ID" value="PJN09999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN09999">
        <property type="protein sequence ID" value="PJN09999"/>
        <property type="gene ID" value="CG723_19950"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="8">
        <location>
            <begin position="80"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="464"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="26"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="468"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="109"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PJN09999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="565" mass="60766" checksum="F37D5A21DED9A205" modified="2018-04-25" version="1">MSNNGGPAYGPNDPTSFGLQPPQQPHTPQQGNPYAQPPTAYPQPQPPHQPPHQPSPTQVVPPRQSAEAEPGAGRLIGGRYRLLSKLGHGGMGTVWRAKDETVDREVAVKEPRVPDHLPERERTTVFERMRREARAAARLDHPAVVNVHDVAVEDGQPWIVMEFVQGRTLGDALQEGTLSAREAARVGLEVLGALEAAHAAGVLHRDVKPDNVMLGRHDRVVLTDFGIAQIEGETNLTDTGGFVGSPEFIAPERVLGQRPGPASDLWSLGVVLYAATEGVSPFRRNNTPATLQSVINATPAAPAAAQGPLAEAINGLLAKDPARRPNAARVRDLLERAANPPVQPPTQVVQLAGPGGKGVSLSRKALLGVGAAVVAAAVVAYLVIANPFAGPLPDGWQDHREKTVAATFAAPPEYVRFEADNSIIKTDHWVSYRDPSYAVSITLSLKKKSEDSVNGIASSASAQAYKDSDEINKGDNSKMADKPAPRSRTAKTTYNDRESAENTITYTDDSDSDELKPREAKVFYYKTKSGDMYQLWIDYPGKGDFTERGREVAKAAIANLDIDKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JT25</accession>
    <name>A0A2M9JT25_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">ATP-dependent DNA helicase</fullName>
            <ecNumber evidence="6">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">pcrA</name>
        <name evidence="10" type="ORF">CG723_19850</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CB01635</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>ATP + H2O = ADP + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the helicase family. UvrD subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="6"/>
    <dbReference type="EMBL" id="NNBL01000006">
        <property type="protein sequence ID" value="PJN09982.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN09982">
        <property type="protein sequence ID" value="PJN09982"/>
        <property type="gene ID" value="CG723_19850"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006268">
        <property type="term" value="P:DNA unwinding involved in DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005751">
        <property type="entry name" value="ATP-dep_DNA_helicase_PcrA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013986">
        <property type="entry name" value="DExx_box_DNA_helicase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014017">
        <property type="entry name" value="DNA_helicase_UvrD-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000212">
        <property type="entry name" value="DNA_helicase_UvrD/REP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014016">
        <property type="entry name" value="UvrD-like_ATP-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11070">
        <property type="entry name" value="PTHR11070"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00580">
        <property type="entry name" value="UvrD-helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13361">
        <property type="entry name" value="UvrD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01073">
        <property type="entry name" value="pcrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51198">
        <property type="entry name" value="UVRD_HELICASE_ATP_BIND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51217">
        <property type="entry name" value="UVRD_HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 6 10" id="KW-0347">Helicase</keyword>
    <keyword evidence="5 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 5 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UvrD-like helicase ATP-binding" evidence="8">
        <location>
            <begin position="71"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="domain" description="UvrD-like helicase C-terminal" evidence="9">
        <location>
            <begin position="368"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="14"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="22"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="92"/>
            <end position="99"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU364053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PJN09982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="836" mass="91818" checksum="2EB4D32E8E082A01" modified="2018-04-25" version="1">MSSLFDDSFLADLTASKASEEHAPPPPEDDTAPEHVPDDLFDGKFDVPPARDEYYRDGAPRPALDPAALLDGLNENQKAAVVHGGSPLLIVAGAGSGKTRVLTHRIAYLLGERGVHPGQILAITFTNKAAGEMKERVESLVGPRANAMWVSTFHSACVRILRRESKKLGFTSSFSIYDAADSKRLMALVCRDLDLDPKKFPPKSFSAKISNLKNELIDEEDFAAQAADGFEKTLAQAYAMYQSRLREANALDFDDLIMTTVHLLRAFPDVAEHYRRRFRHVLVDEYQDTNHAQYALVRELVGSADSGRGEDEPPRADDLPPAELCVVGDADQSIYAFRGATIRNILQFEEDYPDATTILLEQNYRSTQTILSAANAVIERNESRRPKNLWTNAGAGAQITGYVADTEHDEAQFVADEIDRLTDARDAKAGDVAIFYRTNAQSRVFEEIFIRVGLPYKVVGGVRFYERKEVRDVLAYLRVLANPEDSVPLRRILNVPKRGIGDRAEAMIDALSQREKISFPQALRRVDEAYGMAARSTNAVKRFNTLMEDLRTIVESGAGPATVLEAVLERTGYLAELQSSTDPQDETRIENLQELAAVALEFEQESATADGAAEGAGGASVGTLSEFLERVALVADSDQIPDEEDDGSGVITLMTLHTAKGLEFPVVFLTGMEDGVFPHMRSLGQVKELEEERRLAYVGITRARERLYLTRSTLRSAWGQPSYNPPSRFLEEIPDTHLEWKRTGAMAPAKSAGPTSGIAASLSSSRSRSTPAFATRRATEKPVVALSVGDRVTHDQFGLGTVVGVKGTGANAEATVDFGEPKPKRLLLRYAPVEKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JTK3</accession>
    <name>A0A2M9JTK3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">SAM-dependent methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CG723_20055</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000006">
        <property type="protein sequence ID" value="PJN10152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN10152">
        <property type="protein sequence ID" value="PJN10152"/>
        <property type="gene ID" value="CG723_20055"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041698">
        <property type="entry name" value="Methyltransf_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041497">
        <property type="entry name" value="Thump-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13649">
        <property type="entry name" value="Methyltransf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18096">
        <property type="entry name" value="Thump_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransf_25" evidence="2">
        <location>
            <begin position="102"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="domain" description="Thump_like" evidence="3">
        <location>
            <begin position="320"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="390"/>
            <end position="410"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF18096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PJN10152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="410" mass="43213" checksum="65A0251A9ED653E8" modified="2018-04-25" version="1">MNDLASFSSLLSAEGQALLDDVRDITPGQELAVATRLRRDHPAELVSAAIAQARLRQRAAAKFGEADASRMYFTANGVEQATRTSVATHRAQEFKALGVRSVADLCCGIGGDAIALARAGISVLAVDRDPLTCEVARANAQALGLDGLIEVREADVTQVDTEPYDAVFVDPARRGGGKGGGRIFDPEAYSPPLSWAVGAALGARHAALKIAPGIPHEAIPTAADAEWISDGGDVKEAVLWFGTEPGRMRATLLPGPRALIGSGLPDPEVRPVGRYLYEPDGAVIRAHLVADVAEEVAGGLIDETIAYVTSDTLHATPYATAYEITDQLPFNVKKLKALLREREVGILTVKKRGSAVEPEELRRKALPKRHGPNALTVFLTRVAGAPTMLLGAPAQPATGEPAATRRGATP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JTL4</accession>
    <name>A0A2M9JTL4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_17675</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000005">
        <property type="protein sequence ID" value="PJN10225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN10225">
        <property type="protein sequence ID" value="PJN10225"/>
        <property type="gene ID" value="CG723_17675"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="36"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="124"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN10225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="279" mass="29894" checksum="2322B0CE0D6331D6" modified="2018-04-25" version="1">MRRAVRWSFAALVPGELALVLCLASGVRPPPAARSAVELAALALMTASAVLLGLDHRRHHRTGLDHRGAFLAAVADTVPAPVRKLTAHEISLSTSFVRWVARRGPHGVGDGDVPVPYASGQTSFMYGFFFVSVVETVALAFLIPWPLVHAVTLVLDVWGCYFVIALHASCAVRPHVIGSDGSLHLRYGALLGIRIPADRIASVRQDRKFPTSRLAAVDENGVADLAVGGQTTITVELTEPVRYVRALGKPAEAHTFRFYAEDATSAVTALRAADGIHSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JTS0</accession>
    <name>A0A2M9JTS0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_18040</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000005">
        <property type="protein sequence ID" value="PJN10291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN10291">
        <property type="protein sequence ID" value="PJN10291"/>
        <property type="gene ID" value="CG723_18040"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011576">
        <property type="entry name" value="Pyridox_Oxase_put"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01243">
        <property type="entry name" value="Putative_PNPOx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Putative_PNPOx" evidence="1">
        <location>
            <begin position="41"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN10291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="208" mass="23142" checksum="13E641A8AF1078B0" modified="2018-04-25" version="1">MHLRPSTPHPAPSQGERALQAHMGTSERADDFYDRQVRPRLTPAMNEFIARQTMVFLSTADARGHCDTSFRAGPPGFVAVLDDLHLAYPEYRGNGVMASAGNITENPHMGLLFIDFTHDHIGLHVNGSAQLMGDRELRAICPTLPRDSAPGRQAEMWIYITVQEAYVHCSKHIPHLEPAHQPNRRAPGRPKDGDYFTEQMTHACLGQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JTS7</accession>
    <name>A0A2M9JTS7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">VanZ family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_17755</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000005">
        <property type="protein sequence ID" value="PJN10238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN10238">
        <property type="protein sequence ID" value="PJN10238"/>
        <property type="gene ID" value="CG723_17755"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006976">
        <property type="entry name" value="VanZ-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04892">
        <property type="entry name" value="VanZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="17"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="56"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="99"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="133"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="domain" description="VanZ" evidence="2">
        <location>
            <begin position="125"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN10238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="234" mass="24514" checksum="972C8C917A73FCD2" modified="2018-04-25" version="1">MNHDASLPAPPGRTRRIVFLGLAIVALASGAFVVRGPLMMSAPRCMAGRWHGCFDTFNGVVLMTLVALPLAALVAWALTLRRRAAGVTSAWRMSLAEVGMVHGTVPFLWLTMMPGAGAGIVPARVSLVPLRDLVTMGTLGIVGNLLVFASLGFFAPMRFAALASVPRNLALGAGCSVLVETAQYVLRLDRVSSVDDVLVNAAGAVLAALASRHWWRTAAQAPSDQPRPAPAPTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-09-29" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JTT0</accession>
    <name>A0A2M9JTT0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Mycodextranase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CG723_18120</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000005">
        <property type="protein sequence ID" value="PJN10301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN10301">
        <property type="protein sequence ID" value="PJN10301"/>
        <property type="gene ID" value="CG723_18120"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd14490">
        <property type="entry name" value="CBM6-CBM35-CBM36_like_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033801">
        <property type="entry name" value="CBM6-CBM35-CBM36-like_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000421">
        <property type="entry name" value="FA58C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006626">
        <property type="entry name" value="PbH1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024535">
        <property type="entry name" value="Pectate_lyase_SF_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00754">
        <property type="entry name" value="F5_F8_type_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12708">
        <property type="entry name" value="Pectate_lyase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00710">
        <property type="entry name" value="PbH1"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="SSF49785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="SSF51126"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50022">
        <property type="entry name" value="FA58C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014670481" evidence="2">
        <location>
            <begin position="30"/>
            <end position="768"/>
        </location>
    </feature>
    <feature type="domain" description="F5/8 type C" evidence="3">
        <location>
            <begin position="623"/>
            <end position="767"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="601"/>
            <end position="646"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PJN10301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="768" mass="80681" checksum="29D5BAD0D172BD46" modified="2018-04-25" version="1">MVTTLVMALTVSGTATAVALSTSAPAARAAAVQAPSPLDVKDRGAAVPFKEQEAEYAATNGSLTGPDRIYGKLPSEASGRQAVTLDAVGEYVEFTLTAPANAMSFRYSLPDNAAGTGRDASIDLKVNGNQLKSVPVTSKYGWYYGGYPFNNNPGDTNPHHFYDETRTLLGSTLPVGTKIRLQVASVSDSPSFTVDLADFEQVAAPTGKPAGALDVVGDFGADPTGAADSTAKIQAAVDAGKAQNKEVYIPEGTFQVRDHIVVDKVTLRGAGPWYSVLTGRDPSDRSKAVGVYGKYAAQGGSSGVTLKDFAIIGDIRERVDNDQVNAIGGALSDSTVDNVWMQHTKCGAWMDGPMDHLTIKNSRILDQTADGVNFHQGVTNSTVTNTFVRNTGDDGLAMWAEAKPNVADKFTFNTVILPILANNIVTYGGKDIVLSDNVMSDTVTNGGGLHIANRYPGVNSGQGTAVSGTITAARNTLIRAGNNDFNWRFGVGAIWFSGLNEPVDATLNITDSEVLDSSYAAIHLIEGATNGLHFKNIRIDGAGTYALQIQAPGTATFENVTATHIAQNNPIHNCVGSGFQMTRTGTNSGWYADPPACTGTWPDPVWTNGGVPQGGGDPTDPPTDPPSDPGNLAKGRPVAESGHADVYKATNAVDGDAGSYWESTNNAFPQTITVDLGSAKAVKRLVLKLPPAAAWATRTQTLSVSGSTDNSTFTTLRTSAGYTFNPNSGNTTEVALTGTPTRYLRLTFTDNTGWPAAQLSELEAYTDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JTU0</accession>
    <name>A0A2M9JTU0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">MerR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CG723_18180</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000005">
        <property type="protein sequence ID" value="PJN10311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN10311">
        <property type="protein sequence ID" value="PJN10311"/>
        <property type="gene ID" value="CG723_18180"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015689">
        <property type="term" value="P:molybdate ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041657">
        <property type="entry name" value="HTH_17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008995">
        <property type="entry name" value="Mo/tungstate-bd_C_term_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004606">
        <property type="entry name" value="Mop_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010093">
        <property type="entry name" value="SinI_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005116">
        <property type="entry name" value="Transp-assoc_OB_typ1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12728">
        <property type="entry name" value="HTH_17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03459">
        <property type="entry name" value="TOBE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="SSF46955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50331">
        <property type="entry name" value="SSF50331"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01764">
        <property type="entry name" value="excise"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00638">
        <property type="entry name" value="Mop"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51866">
        <property type="entry name" value="MOP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0500">Molybdenum</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mop" evidence="3">
        <location>
            <begin position="66"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PJN10311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="132" mass="13839" checksum="A2A264D1356BA271" modified="2018-04-25" version="1">MSSYSIGQAARLLGVSGETVRRWADSGRLTMGRDGTGNRVIDGVGLARFAKSRAAEADRGANGAPRTSVRNSFTGIVTALKADDVVAQVEIQAGPHRMVSMVTREAVEELGLAVGVTVTARVKSTSVHVDRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JTW3</accession>
    <name>A0A2M9JTW3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CG723_18165</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000005">
        <property type="protein sequence ID" value="PJN10309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN10309">
        <property type="protein sequence ID" value="PJN10309"/>
        <property type="gene ID" value="CG723_18165"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PJN10309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="60" mass="6540" checksum="974A89868F746CEE" modified="2018-04-25" version="1">MPEQELEVEQRREPSVPLGVGVRRATLDDGRVVTIVCEAGLPQNEVNAIAARVAESSLKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-06-02" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JTX5</accession>
    <name>A0A2M9JTX5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Plasmid stabilization protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_18370</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000005">
        <property type="protein sequence ID" value="PJN10341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN10341">
        <property type="protein sequence ID" value="PJN10341"/>
        <property type="gene ID" value="CG723_18370"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="88"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="49"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="90"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN10341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="107" mass="11906" checksum="3D26B31A67464E59" modified="2018-04-25" version="1">MPRGSNAKRERQYEHIKESAEERGESRKRAEEIAARTVNKERARAGESRTASRSSTQDMSSGKRGGQRSHSGAGGLTYDQLYAEAQRRNIHGRSSMDKAELKKALGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JTY5</accession>
    <name>A0A2M9JTY5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MarR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_18025</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000005">
        <property type="protein sequence ID" value="PJN10288.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN10288">
        <property type="protein sequence ID" value="PJN10288"/>
        <property type="gene ID" value="CG723_18025"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000835">
        <property type="entry name" value="HTH_MarR-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12802">
        <property type="entry name" value="MarR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00347">
        <property type="entry name" value="HTH_MARR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50995">
        <property type="entry name" value="HTH_MARR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH marR-type" evidence="1">
        <location>
            <begin position="1"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN10288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="151" mass="17009" checksum="5327F8D0F6442AF0" modified="2018-04-25" version="1">MARPTYELEYEQMLLSRHGLVHHKGGRPENGTLERSAYILLSRIRVQGPMSIGELSDAFGLDASTLNRQTAAAMRAGLVERIPDPDGGMARKFRITDKGAAVLDEERDHIVGSLDRVMTDWADEDIAAFTTYLRRFNMDIERLGGRPWPRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JUA2</accession>
    <name>A0A2M9JUA2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Type 1 glutamine amidotransferase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_18760</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000005">
        <property type="protein sequence ID" value="PJN10402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN10402">
        <property type="protein sequence ID" value="PJN10402"/>
        <property type="gene ID" value="CG723_18760"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002818">
        <property type="entry name" value="DJ-1/PfpI"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01965">
        <property type="entry name" value="DJ-1_PfpI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DJ-1_PfpI" evidence="1">
        <location>
            <begin position="27"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN10402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="231" mass="24005" checksum="D14C6AA0A0E4100C" modified="2018-04-25" version="1">MSKILFVVTGATYWTLADGTLHPTGFWAEEAVAPYEAFKAAGYDIVVATPGGVVPTVDKGSLAPEFNGGQEGADQVAAALASFSELQHPVKVEDVNLDDYAAVFYPGGHGPMEDLSADADSGRLLALALETGKPLGIVCHAPAAMLAAIKGDGSNAFAGYKATAFTNAEETQAGFADKAKWLLQDRLVNAGVDFQEGEPWAPKTVVDRNLVTGQNPSSAAPLAAELLKKLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JUD4</accession>
    <name>A0A2M9JUD4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_18645</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000005">
        <property type="protein sequence ID" value="PJN10387.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN10387">
        <property type="protein sequence ID" value="PJN10387"/>
        <property type="gene ID" value="CG723_18645"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000757">
        <property type="entry name" value="GH16"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00722">
        <property type="entry name" value="Glyco_hydro_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="SSF49899"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51762">
        <property type="entry name" value="GH16_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014857724" evidence="1">
        <location>
            <begin position="35"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="domain" description="GH16" evidence="2">
        <location>
            <begin position="30"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN10387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="292" mass="30965" checksum="511DCE1CE710CD8B" modified="2018-04-25" version="1">MTVRSSWRRRASLYAASLACCAASLAAMPSGASAAPAPIDSPAKAAAAATFTDDFNGAAGSAVDGGKWQIETGDNVNNHERQYYTAGNSNAALDGQGNLVITARKENPNNYQCWYGRCEYTSARLNTSGKFTQAYGHVEARMKVPRGQGMWPAFWMLGDDIGSVGWPASGEIDVMENVGFEPSTVHGTLHGPGYSGSGGIGAAYTLPGGQAFADGFHTFAVDWAPNSVKWSVDGNVYQTRTPADVGGNQWAFNKPFFLILNLAVGGYWPGDPDGSTSFPQQLVVDYVHVTTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JUR0</accession>
    <name>A0A2M9JUR0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_15440</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000004">
        <property type="protein sequence ID" value="PJN10609.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN10609">
        <property type="protein sequence ID" value="PJN10609"/>
        <property type="gene ID" value="CG723_15440"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010390">
        <property type="entry name" value="DUF990"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06182">
        <property type="entry name" value="ABC2_membrane_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="24"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="64"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="121"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="146"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="180"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="237"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN10609.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="270" mass="28703" checksum="14FCE4651724E8EF" modified="2018-04-25" version="1">MGTFRLYAAVAAGGFRRYATYRSATAAGVFTNTVFGFIVAYTYMALWDERPGLGGYDQAQALTYVWIGQALAQALSMFNAGFAVDMVARIRNGDIAVDLYRPVDLQLWWLAGDLGRAAFQLFSRGVVPLTVGALAFPLALPGDPVVWLEFLVAVVLAVVVSFAIRYVLALSAFWLLDGSGVLQFGGLVGMFFTGLLLPLNAMPGALGDIARVLPWAALLQMPADILLGARSGAAEVLAAYAFQVGWAVVLLAAGRLLQSSATRKVVLQGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JUW8</accession>
    <name>A0A2M9JUW8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Histidine phosphatase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CG723_15900</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000004">
        <property type="protein sequence ID" value="PJN10685.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN10685">
        <property type="protein sequence ID" value="PJN10685"/>
        <property type="gene ID" value="CG723_15900"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd07067">
        <property type="entry name" value="HP_PGM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00300">
        <property type="entry name" value="His_Phos_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00855">
        <property type="entry name" value="PGAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="SSF53254"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PJN10685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="201" mass="22428" checksum="8CBAD4C820DAFE58" modified="2018-04-25" version="1">MAPRILLARHGQTEWSLSGRHTGRTDIPLLEEGRRGAKLLGERLHRSPLDGLPGAEVRTSPLSRARETCDLAGFGDRATEWDTLMEWDYGAYEGLTPAEIQERRPGWFIWRDGVPEGETLEQMTARADEVVAWARSENRDALVFAHGHMLRSIGARWLGLPLDFAARIRLNPTSLSVLGWAYGDPAIESWNDIGHLAGHEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JUZ0</accession>
    <name>A0A2M9JUZ0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CG723_16000</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000004">
        <property type="protein sequence ID" value="PJN10701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN10701">
        <property type="protein sequence ID" value="PJN10701"/>
        <property type="gene ID" value="CG723_16000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PJN10701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="85" mass="9931" checksum="59B27F07FC96AC3B" modified="2018-04-25" version="1">MHDELVDHLTRSSPLNRGEALRVIQDVLAYFDETTEVFVRRRHRELQGQGLVNAEIFERISADLKYRAVAPPELSLRQLRRIVYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JVD5</accession>
    <name>A0A2M9JVD5_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5">Cell shape-determining protein MreC</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4 5">Cell shape protein MreC</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CG723_16815</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CB01635</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Involved in formation and maintenance of cell shape.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the MreC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000004">
        <property type="protein sequence ID" value="PJN10833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN10833">
        <property type="protein sequence ID" value="PJN10833"/>
        <property type="gene ID" value="CG723_16815"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.340">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.350">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042177">
        <property type="entry name" value="Cell/Rod_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042175">
        <property type="entry name" value="Cell/Rod_MreC_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007221">
        <property type="entry name" value="MreC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34138">
        <property type="entry name" value="PTHR34138"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04085">
        <property type="entry name" value="MreC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038471">
        <property type="entry name" value="MreC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00219">
        <property type="entry name" value="mreC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0133">Cell shape</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="276"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="292"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009369"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013855"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00032089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR038471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PJN10833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="315" mass="33071" checksum="E50E4D69EA8BDCB5" modified="2018-04-25" version="1">MRDTRESRLLLVLLIAIAFALITVDIRGGEDSPVDGARRAAATVFGPVENGVSSAVDPIGNAIAAVKDSGERHNRVSELERENAALKAKLGSDDRNRSKIRQLDSMLKTAGAGQYGIKGAQVIAIGAAQGFSWTVTIDAGANDGLKRDMTVLNGDGLVGRVTTVGPNTATVLLANDPDFTVGTRMERTDELGFASGQGDRPLRVQLLNGKAEIKKGDRLVTFGSQADKPFVPGVPVGQVVRVDPSGGDLTRTIYVKPYVGFTKLDVVGVVVQAPRTDPRDEVLPSKPAKPKPTPTVTVTATPSGTPADANGIDEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JVY7</accession>
    <name>A0A2M9JVY7_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Potassium-transporting ATPase potassium-binding subunit</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">ATP phosphohydrolase [potassium-transporting] A chain</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Potassium-binding and translocating subunit A</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Potassium-translocating ATPase A chain</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">kdpA</name>
        <name evidence="10" type="ORF">CG723_08255</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CB01635</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds the extracellular potassium ions and delivers the ions to the membrane domain of KdpB through an intramembrane tunnel.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">The system is composed of three essential subunits: KdpA, KdpB and KdpC.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cell membrane</location>
            <topology evidence="9">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the KdpA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN10988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN10988">
        <property type="protein sequence ID" value="PJN10988"/>
        <property type="gene ID" value="CG723_08255"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008556">
        <property type="term" value="F:P-type potassium transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030955">
        <property type="term" value="F:potassium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00275">
        <property type="entry name" value="KdpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004623">
        <property type="entry name" value="KdpA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30607">
        <property type="entry name" value="PTHR30607"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03814">
        <property type="entry name" value="KdpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001294">
        <property type="entry name" value="K_ATPaseA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00680">
        <property type="entry name" value="kdpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 9" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 9" id="KW-0630">Potassium</keyword>
    <keyword evidence="3 9" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="61"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="137"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="176"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="249"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="280"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="376"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="415"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="481"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="522"/>
            <end position="544"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PJN10988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="554" mass="58336" checksum="01A12F7FA932E98E" modified="2018-04-25" version="1">MSPVLAGVLQLLALIVALGLAYRPLGDYMARVYSSDKHLRVEKWIYKGIGANPNAEMRWMAYLRGVLAFSAVSVLFLYLLQRFQGSLPGSLGFSAIDPDQAFNTAASFVSNTNWQSYYGEQAMGHVVQTAGLAVQNFVSAAVGIAVAVALVRGFARSRTGELGNFWSDLVRGTVRILIPISVVGAIVLVACGAIQNFSGIHEVGQFMGGSQQWNGGAVASQEAIKELGTNGGGYFNANSAHPFENPNGFTNLFEIFLILVIPFALTRTFGRMVGSLKQGYAILATMVTIWIGFTALMMWTEFHHGAPAFDIAGGAMEGKENRFGVGGSSIFAVATTLTSTGAVDSFHSSFTGFGGGITMLGMQLGEIAPGGTGSGLYGMLIMAIIAVFIAGLMVGRTPEYLGKKIGTREIKFAACYILITPALVLVFTAISMALPTPPNSMLNSGAHGFSEILYAYTSGANNNGSAFAGLSADTQWFNTTIGLAMLLGRFLPMVFVLALAGSLAEQRPVPATAGTLRTEKPLFTGLLVGTILILTGLTYFPALALGPLAEGLAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JW43</accession>
    <name>A0A2M9JW43_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CG723_08890</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">CB01635</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN11079.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN11079">
        <property type="protein sequence ID" value="PJN11079"/>
        <property type="gene ID" value="CG723_08890"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_supfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="SSF50998"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12" id="KW-0418">Kinase</keyword>
    <keyword evidence="6 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="12" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="9" id="KW-0802">TPR repeat</keyword>
    <keyword evidence="12" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 8" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="Protein kinase" evidence="11">
        <location>
            <begin position="20"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="9">
        <location>
            <begin position="313"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="468"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="500"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="637"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="670"/>
            <end position="712"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="848"/>
            <end position="882"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="966"/>
            <end position="1007"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="1057"/>
            <end position="1098"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="1099"/>
            <end position="1132"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="49"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PJN11079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="1145" mass="123298" checksum="2C5A255B244AE3DC" modified="2018-04-25" version="1">MGAPTPSAVWSTGTTVDGRYRVLGELGRGGMGVVHRVRHLAWGIDMAVKSSRPEVFRELGDRELFVREAEAWVSLGLHPNICACHYVRVIAGVPRVFAEYVDGGSLAEWIGDGRLYAGDARQILARVLDTAVQAARGLEHAHRRDLVHQDVKPANILLDGAGAAKITDFGLARSMAAVASTTSETAPGASVLVPWGGMTVGYASPEQLAGERVGRRSDVYSFAVTVLEMFTGGVRWSAGSVAGLALEEYLVDPANPVAAPSEVAHLLRRCLRQHPADRPPSMADIADVLTGIYEQQTGSTYPRPTPQEADLRADELNNRGLSLLDLNRASDAEQAFDQALAVDPHHVGAVYNGGLLRWRTGAITDAELVTRLEAIPQGSGASARQTDLLLARVHLERGDLAAAHGLLGALARERPDGADVRAALRVATSGSVTDARHTGTRPVSEPFALPGAPVKLLARHEVMGYLPIRFTPDGRLAVSGHWDGVIRLWDTATGAQRMALKGQRTQVLGVDLTPDGSYALSTSRGGTVQFWDLRAGRCSRAIHAVAHATGCPVSLSADGRIGVWKGADGRVQVWELGTGTCRWLLGPAIKDGALDGSLYEVSADGRHVLTAENDGARLWSVADGLCRVLAAGSRTHALCFSPDGRLAAIAGQDRVIRLWDVEDGRQVRTLTGDTAAAGHLAFSHDGRRLLSGTTGDHTVRLWELDSGRCLRTFSADAYGMHHVGFRDTDARFGCSVGGHPELPLHHWQLPDAGYVAEPHVSKPREYAEVSRLGGLAEELIADARKALSNGRHRSALDLLTRARAVPGYERAPQALAAWHELSRTARHVGLRAAWSQPLDAGPLPFGGITAIGVAAGARLAVSGQSDGSIRIWDLDRGTCTRVLDDHRGRVGEVALSDDGRHVLCKATKPLAITRWRLADGERRQVTPDWDMTRTVLFTGDGRHAWFGGGDGVIRRWDLNDDRCVATIGSRGAVNVISTSTDGRLAAVGDSNGVVRLWDLDTGTCLRTWSGPREPILSACLSADGRLALSTHMVTSSGGQNEPIRLWDAGTERCLRTFEGHEGWSSAVRFTPDARFAFSAAHDRTIRLWEVATGRCLHVLEGHQGYIRHLELTPDSRNLVSAGDDGIRLWHLDWELATDATQRDEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JWA0</accession>
    <name>A0A2M9JWA0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">IclR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CG723_09475</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN11170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN11170">
        <property type="protein sequence ID" value="PJN11170"/>
        <property type="gene ID" value="CG723_09475"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014757">
        <property type="entry name" value="Tscrpt_reg_IclR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005471">
        <property type="entry name" value="Tscrpt_reg_IclR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09339">
        <property type="entry name" value="HTH_IclR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01614">
        <property type="entry name" value="IclR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00346">
        <property type="entry name" value="HTH_ICLR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51077">
        <property type="entry name" value="HTH_ICLR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51078">
        <property type="entry name" value="ICLR_ED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH iclR-type" evidence="3">
        <location>
            <begin position="9"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="domain" description="IclR-ED" evidence="4">
        <location>
            <begin position="70"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PJN11170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="250" mass="26508" checksum="8A491CC7086FCFFD" modified="2018-04-25" version="1">MATTSANPMRSVDRAFDVLGVLEDARHPLRLSELARRAELHVATAQRILNVLVDRGYAAKEESGYVAGPAAVATAHAFLVNNRLSPVALPVLQELAATTGLTPTLFVRVGSARVPIARVEGRNPLRYQLPIGDKLPLHLGAGKALLAWLPEDEQAVVVAAATPFSRASGQQVTAEELVAELRRVHDDGYALAQGERVLDVTSVSAPILKGDTLLGALSIVGPSSDLPESDHPRIITEVRHAAEAVAARCP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JWC7</accession>
    <name>A0A2M9JWC7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Alpha/beta hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CG723_09230</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN11132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN11132">
        <property type="protein sequence ID" value="PJN11132"/>
        <property type="gene ID" value="CG723_09230"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013595">
        <property type="entry name" value="Pept_S33_TAP-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08386">
        <property type="entry name" value="Abhydrolase_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014909416" evidence="2">
        <location>
            <begin position="35"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="domain" description="AB hydrolase-1" evidence="3">
        <location>
            <begin position="96"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="domain" description="Abhydrolase_4" evidence="4">
        <location>
            <begin position="415"/>
            <end position="514"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PJN11132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="542" mass="57573" checksum="921E89EAE71CE2DC" modified="2018-04-25" version="1">MHISGPIAGRRVCAAVIAALVAGSTVLTGQILAAAGGPPAPSVPAPKLDWRPCVQGSPFDCATAKVPLDYNDPGRRTIELAVIKRKATDPGRRIGTLLFNPGGPGGPGTVQMPQDYDFFPREVRERFDIVSWDPRGIGSSTAVNCFATPEEAAAWNAGKPAGVPVGAQQRATVIAAYEDLARRCERRDPELLRHVSTADTARDLDGLRQAVGDAQLTYLGISYGTILGATYANLFPGRVRAMVLDSDIDPQAWTNHGSDADPRLTTFLRMGLDRAAAAVLERFLTLCGSTDTAGCTFSAGSPKATRDRFDQLMRRLRAHPVGEWTYGRTVADVMSSLYVVHPGWTDLAGRLRDLWQGRVAKASPLPPPPMVPHPNPYVGEEQAGAVLCGESPNPRDPAVYPAMEEAAAGRAGDAGLFWTWATAGCVSWPAVAADRYRGPWNRQTAHPVLVVGTRYDPATPYADAQALAGELADARLLTHEGYGHTALINPSSCVKAYESRYLVDGTLPPAGTTCRQDEPPFRAPKLVGGVATGGGGMAGTVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JWW0</accession>
    <name>A0A2M9JWW0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Short-chain dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_10705</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN11385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN11385">
        <property type="protein sequence ID" value="PJN11385"/>
        <property type="gene ID" value="CG723_10705"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="232"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN11385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="314" mass="32596" checksum="53195B86E92705B2" modified="2018-04-25" version="1">MTDSTGPARTTTPQGLPTPPPAGTTALPPGTYRGSLVLVTGGGTGLGKAVAAEFARLGADVMIVSRRAAHLEPALEELGRVSRDGGTVTAAVCDIRDPDRIAEVFDTAEAAHGRTPDVLVNNAAANFPVPAEDMSPNAWRTVVDITLNGTFYMTREFGRRHLAAGTPGSVIAVGASYAWTGGPGFAHSAAAKAGVKNLVETLAVEWGPYGIQVNGLVPGLMPHEDMTGDIRANLERGGPEGGLGGGADHDARQPALRVGAPRELGWAATFLASPYARFISGHTLVVDGANWQRRGLVSPPVVTVREQMGRGPFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JX17</accession>
    <name>A0A2M9JX17_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CG723_10610</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CB01635</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN11368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN11368">
        <property type="protein sequence ID" value="PJN11368"/>
        <property type="gene ID" value="CG723_10610"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="31"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="67"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="92"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="154"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="190"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="27"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PJN11368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="223" mass="23041" checksum="A3E6722AF387CB48" modified="2018-04-25" version="1">MKTLTDAWGWLADASHWSGDDGIWHRLAQHVVLTLVCLVISCLIALPVALVLGHLGKGGALAVNISNVGRAVPTFAVLVLLLLTPLGKYGEGPTVVALVLFAVPPLLTNAYVGMRGVDRDIVQAARGMGMTGRQMLFQVEAPLALPMIMNGVRIAAVQLVATATIAALAGGGGLGRIITAGFNLASTPQVVAGAVLVAVFALLVEGVFELAERFAPALARGRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JXN6</accession>
    <name>A0A2M9JXN6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_11970</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN11598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN11598">
        <property type="protein sequence ID" value="PJN11598"/>
        <property type="gene ID" value="CG723_11970"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="40"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="67"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="93"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="117"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="141"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="168"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="435"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="459"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="486"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="510"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="534"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="563"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="384"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="387"/>
            <end position="428"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN11598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="767" mass="82518" checksum="B75194EBBC66E472" modified="2018-04-25" version="1">MLRRPRIMAGSGGCGRVRAVTRVTRIGGTWDRFVASDPGLLRLMAGLRTVGAIALTLAVLAAFHTDVTHMVAGAMAAMVATFAIREKDVRGQAVTLALGLPVALAAVSLAALLHNQVVAGDLFFIALIFGAVYSRRFGDRGTALGLIGFQIYFVSLFVSATVSSLPRLYATLAVAFACSAVVRFAVVPETPERVLGRLRDAFRARLAQLVDTQAELLDAEPDQLERVLDDLRRGTARLHETALMIQGRLEEGTRDSATAALVQRRVADAEIAAERLGVLLLNARSAERADTLTLHLPHAPVPEPSKRLHADDDVTATLRRDLNALHLLVARPVTGNRGTAVAHVRNRLLAYRDEDNLPRGSAAVQDVFRGIGEAARAVMGLRVALDGPQDESDDSPATTRSREELDAEDLAITSSEQDEGDKDDRTGLRRPTTRAAFQVAVGSSLAIVGGEFLSSQRWYWAVLTCWVVFLNTASTGEILVKGYRRLLGTVFGVVAGVALAGVVGNHTWTAFALVLVFIFAMFFTAPLSYALMSFFVTAMLGLLYTLLNTYSLDVLVLRIEETALGAACGIVAAVLVLPVHTDRRTDELLSTVLVRLGDVVSAAVEQLSGGPAVDLLDKARDLDTALDDLRASTKPLTHPITPLRVRRQTARYLVALLETCAYHARSLAATAELVPYSKTIAADPRLERAGVRIAHNIDVIDAHVRDEKTGGEVEAGASIASMLEADGTGALRSGTVTFRVLRHLQRLDEGVVGLARPLDVPVARHRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-09-29" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JXN7</accession>
    <name>A0A2M9JXN7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_12165</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN11631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN11631">
        <property type="protein sequence ID" value="PJN11631"/>
        <property type="gene ID" value="CG723_12165"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="56"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="83"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="113"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="150"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="176"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="220"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="249"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="283"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="316"/>
            <end position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN11631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="423" mass="42961" checksum="7918BA10110CF915" modified="2018-04-25" version="1">MATTTKIQPRALVRASGGPRYAVALAVDALGTGLLRPFLLLYGVNVLRLSPPATGIAMTGGVVVGLVCMPAVGRWLDRGARSTVVAASMLVRVLGVALLLATPAGHVRLFATAALFLGIGNQAWPAAHAALVATVVHGRERDTALAAGRALRNAGLGAGALLAAACLTGGTTALQTLAAVTGLAYLTAAALAWSVHVRAHPAAAPAKDRDDGPAPRMRALLAANVIYAFCLNVPEIALPLVLWSQLHASSVWSAAIFVANTVLVVTLQVPVTVLMSRFSRRTVLALAGVVLAASYLGFLVATSLGHGWGAPAVATVSVVCTIGEIIYAGSATALVTVLAPAHVLGRALARFQLSTGFGLAVSPAAITTLASRGSAALWGSLAAATLLSASAVATEKDQGTRLSGCCRRARAGSRARRSPRETP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JXR5</accession>
    <name>A0A2M9JXR5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">TIGR03086 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_12465</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN11676.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN11676">
        <property type="protein sequence ID" value="PJN11676"/>
        <property type="gene ID" value="CG723_12465"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017517">
        <property type="entry name" value="CHP03083_actinobac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017520">
        <property type="entry name" value="CHP03086"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034660">
        <property type="entry name" value="DinB/YfiT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024344">
        <property type="entry name" value="MDMPI_metal-binding"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11716">
        <property type="entry name" value="MDMPI_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109854">
        <property type="entry name" value="SSF109854"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03083">
        <property type="entry name" value="TIGR03083"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03086">
        <property type="entry name" value="TIGR03086"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MDMPI_N" evidence="1">
        <location>
            <begin position="13"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF11716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN11676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="201" mass="21114" checksum="E5A984A0E6BF9E9A" modified="2018-04-25" version="1">MPTNKDLVALDAEAVRTSVDVVARATAGDLVRPTPCAGWTLRDLLGHMAAQHYGFAAASRGEADIAVWQPRPLGDDPVGAYRAAAQHVLEAFAVDGVTERAFPLPEIRDGGPFLGAQAVSFHLVDYVVHSWDVARTLGHTVTFDPELLDAALAVARVVPGGEARRGPRAAFAPAITADGGTRLDEIVAILGRSPAWQPGPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JXW7</accession>
    <name>A0A2M9JXW7_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Aminopeptidase N</fullName>
            <ecNumber evidence="4">3.4.11.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CG723_12565</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">CB01635</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Release of an N-terminal amino acid, Xaa-|-Yaa- from a peptide, amide or arylamide. Xaa is preferably Ala, but may be most amino acids including Pro (slow action). When a terminal hydrophobic residue is followed by a prolyl residue, the two may be released as an intact Xaa-Pro dipeptide.</text>
            <dbReference type="EC" id="3.4.11.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the peptidase M1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.11.2" evidence="4"/>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN11692.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN11692">
        <property type="protein sequence ID" value="PJN11692"/>
        <property type="gene ID" value="CG723_12565"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1730">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045357">
        <property type="entry name" value="Aminopeptidase_N-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042097">
        <property type="entry name" value="Aminopeptidase_N-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001930">
        <property type="entry name" value="Peptidase_M1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014782">
        <property type="entry name" value="Peptidase_M1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027268">
        <property type="entry name" value="Peptidase_M4/M1_CTD_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01433">
        <property type="entry name" value="Peptidase_M1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17900">
        <property type="entry name" value="Peptidase_M1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00756">
        <property type="entry name" value="ALADIPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63737">
        <property type="entry name" value="SSF63737"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="6" id="KW-0645">Protease</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase_M1_N" evidence="13">
        <location>
            <begin position="154"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M1" evidence="12">
        <location>
            <begin position="261"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="15"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012564"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00015611"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF17900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="PJN11692.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="468" mass="51636" checksum="3391C412EE40FD6E" modified="2018-04-25" version="1">MRTARGGGHDTDTLGTAQGVDTSVSGQTAASEPYFPGHGDPRYRVHRYELSLDYRPGPNRLAGHARISAIAGRAPLTEFHLNLEAFRLGKVLVDGRQPRYTHRGGKLRIRPVKPLRAGAAFTVEVHWSGNPKPVNSPWGGLGWEELSDGALVASQPVGAPSWFPCNDRPDDKAAYQISLTVPSPYTVVVGGRLLTRTTKSSTTTWVYEQQAPTPSYLVGLSIGMYQTVLLGEPGLGGVPQSAYVPVRLLSEFSRDFARQPEMMRLFEDLFGPYPFGEYAVVVADEDFDVPVEAQGLSLFGANHVDGARGWERLVAHELAHQWFGNSLTIADWRDIWLNEGFAKYAEWLWSERSGGRSTQELAAAAHRELSVLPQDLLLADPGRKSLFDDQVYERGGLTVHAIRCALGDEPFFRMVRDWVSAHRHGVVTTEAFTAHVARYAAAPVGDLLTAWLRRRPLPPLPAPLVPYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JXX3</accession>
    <name>A0A2M9JXX3_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">zf-CGNR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_12790</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN11730.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN11730">
        <property type="protein sequence ID" value="PJN11730"/>
        <property type="gene ID" value="CG723_12790"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3300.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010852">
        <property type="entry name" value="ABATE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023286">
        <property type="entry name" value="ABATE_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021005">
        <property type="entry name" value="Znf_CGNR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35525">
        <property type="entry name" value="PTHR35525"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07336">
        <property type="entry name" value="ABATE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11706">
        <property type="entry name" value="zf-CGNR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160904">
        <property type="entry name" value="SSF160904"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="zf-CGNR" evidence="2">
        <location>
            <begin position="147"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF11706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN11730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="195" mass="20846" checksum="AE2CF4DFC8B01A9B" modified="2018-04-25" version="1">MSDGEPLTGEPLALDLVNTRPTGPDGRPADLIDTPRRLAVWLDLEGDRLPEGFGRATPSADDLAAVHAVRAHIEATLRAVTDGNAPPDSALRALTEAQRLAPAVRELAWDGAAVTAAPRRTGSLGVRLAAHLAESAADLLTDPGIARVRQCEAEDCVLLFLPAHPRRRWCSAARCGNRARVARYYQRHKATTANG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JY40</accession>
    <name>A0A2M9JY40_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Methylated-DNA--protein-cysteine methyltransferase</fullName>
            <ecNumber evidence="1">2.1.1.63</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">6-O-methylguanine-DNA methyltransferase</fullName>
            <shortName evidence="1">MGMT</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">O-6-methylguanine-DNA-alkyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_13185</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction: the enzyme is irreversibly inactivated.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 4-O-methyl-thymidine in DNA + L-cysteinyl-[protein] = a thymidine in DNA + S-methyl-L-cysteinyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:53428"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:10132"/>
            <dbReference type="Rhea" id="RHEA-COMP:13555"/>
            <dbReference type="Rhea" id="RHEA-COMP:13556"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:82612"/>
            <dbReference type="ChEBI" id="CHEBI:137386"/>
            <dbReference type="ChEBI" id="CHEBI:137387"/>
            <dbReference type="EC" id="2.1.1.63"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 6-O-methyl-2'-deoxyguanosine in DNA + L-cysteinyl-[protein] = a 2'-deoxyguanosine in DNA + S-methyl-L-cysteinyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:24000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:10132"/>
            <dbReference type="Rhea" id="RHEA-COMP:11367"/>
            <dbReference type="Rhea" id="RHEA-COMP:11368"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:82612"/>
            <dbReference type="ChEBI" id="CHEBI:85445"/>
            <dbReference type="ChEBI" id="CHEBI:85448"/>
            <dbReference type="EC" id="2.1.1.63"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="miscellaneous">
        <text evidence="1">This enzyme catalyzes only one turnover and therefore is not strictly catalytic. According to one definition, an enzyme is a biocatalyst that acts repeatedly and over many reaction cycles.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the MGMT family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.63" evidence="1"/>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN11795.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN11795">
        <property type="protein sequence ID" value="PJN11795"/>
        <property type="gene ID" value="CG723_13185"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003908">
        <property type="term" value="F:methylated-DNA-[protein]-cysteine S-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006307">
        <property type="term" value="P:DNA dealkylation involved in DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06445">
        <property type="entry name" value="ATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00772">
        <property type="entry name" value="OGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014048">
        <property type="entry name" value="MethylDNA_cys_MeTrfase_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036217">
        <property type="entry name" value="MethylDNA_cys_MeTrfase_DNAb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023546">
        <property type="entry name" value="MGMT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036631">
        <property type="entry name" value="MGMT_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01035">
        <property type="entry name" value="DNA_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46767">
        <property type="entry name" value="SSF46767"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53155">
        <property type="entry name" value="SSF53155"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00589">
        <property type="entry name" value="ogt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1" id="KW-0227">DNA damage</keyword>
    <keyword evidence="1" id="KW-0234">DNA repair</keyword>
    <keyword evidence="1 3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DNA_binding_1" evidence="2">
        <location>
            <begin position="83"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile; methyl group acceptor" evidence="1">
        <location>
            <position position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN11795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="168" mass="17753" checksum="1B16FC1FC887D3C8" modified="2018-04-25" version="1">MTVYTTLDSPLGELLLVGEESATAKGGTALAALTVPGQKNGTVVKDDWAEDADAFTEITAQLRSYFDGRLTHFDIEYTGSGSEFQQRVWKALEAIPYGSTLTYGDVAARIGAPKAAVRAVGTAIGANPLLVVRPCHRVIGANGALTGYAGGLERKRQLLDLEGLRQTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JY52</accession>
    <name>A0A2M9JY52_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alkylhydroperoxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_13210</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN11800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN11800">
        <property type="protein sequence ID" value="PJN11800"/>
        <property type="gene ID" value="CG723_13210"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004601">
        <property type="term" value="F:peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051920">
        <property type="term" value="F:peroxiredoxin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029032">
        <property type="entry name" value="AhpD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004675">
        <property type="entry name" value="AhpD_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003779">
        <property type="entry name" value="CMD-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02627">
        <property type="entry name" value="CMD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69118">
        <property type="entry name" value="SSF69118"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00778">
        <property type="entry name" value="ahpD_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CMD" evidence="1">
        <location>
            <begin position="27"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02627"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN11800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="158" mass="17010" checksum="F8DD371EA81CF62F" modified="2018-04-25" version="1">MEEARLNLFANHVGAKVLKHINSGAKVVTDSTLPAATQELVKIRASQINGCSFCTDMHTKDATAAGEDQTRLNMVAAWREAKVFNDAERAALELTEQGTRIADAGGGVSDEAWANAAKYYDEDQLTALVSLIALINAYNRVNVLVQQPAGDYQPGQFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JY75</accession>
    <name>A0A2M9JY75_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CG723_13335</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN11820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN11820">
        <property type="protein sequence ID" value="PJN11820"/>
        <property type="gene ID" value="CG723_13335"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034660">
        <property type="entry name" value="DinB/YfiT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007061">
        <property type="entry name" value="DUF664"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04978">
        <property type="entry name" value="DUF664"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109854">
        <property type="entry name" value="SSF109854"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PJN11820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="197" mass="21878" checksum="53AD9F1657256C05" modified="2018-04-25" version="1">MNASEPKADLHFYLQSARDALLWKLEGLSEYDIRRPLTPTGTNLLGLVKHVAGVELGYLGDTFGRPSGEPMPWVEESAELNADMWATADESREFIVELYRRAWAHADATIDALPLDTVGKVPWWPSGRDEVTLNHAVVRVIADTHRHAGHADIIRELLDGASGMSKGNDSMASDDPAWWEDHRGRVERAAREADRGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JY79</accession>
    <name>A0A2M9JY79_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Amidohydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_13315</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN11818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN11818">
        <property type="protein sequence ID" value="PJN11818"/>
        <property type="gene ID" value="CG723_13315"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017439">
        <property type="entry name" value="Amidohydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036264">
        <property type="entry name" value="Bact_exopeptidase_dim_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002933">
        <property type="entry name" value="Peptidase_M20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011650">
        <property type="entry name" value="Peptidase_M20_dimer"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11014">
        <property type="entry name" value="PTHR11014"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07687">
        <property type="entry name" value="M20_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01546">
        <property type="entry name" value="Peptidase_M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005962">
        <property type="entry name" value="Pept_M20D_amidohydro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55031">
        <property type="entry name" value="SSF55031"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01891">
        <property type="entry name" value="amidohydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="M20_dimer" evidence="2">
        <location>
            <begin position="213"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="382"/>
            <end position="401"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN11818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="429" mass="44679" checksum="7E51E35F96995CBA" modified="2018-04-25" version="1">METDGSLTVAAPREGDALRDGLDPRLPALGLLYRDLHSHPELSMQEHRTAGIVATELRGQGWEVTEGVGGTGVVGVLRNGEGPVVALRADMDGLPVREATGLDYASTDTALSPDGERVPLMHACGHDLHTAALLGATGRLAAHRELWRGTLLAIFQPGEETGAGARAMLADGLLERFPRPDVVLGQHVGPLPLGSVATRPGVVMAAADSLRARLLGRGGHGSAPHATVDPVVMAAATVMRLQGIVAREVSPTESAVVTVGSLRAGTKENIIPDEAELKINIRTFDAAVRERVLAAVRRTVEGEAATSGAPRPPEFSELNSFPLTVNSDGATERVLQALGAGGAQVHTLRSPLSGSEDFGLLATAAECPSVFWFFGGTEPSGWEGADPAGEQPPTVHGNHSPFFAPVADPALRNGVTHLLDAAAEWLDSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JYM1</accession>
    <name>A0A2M9JYM1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CG723_13560</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN11857.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN11857">
        <property type="protein sequence ID" value="PJN11857"/>
        <property type="gene ID" value="CG723_13560"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PJN11857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="166" mass="17413" checksum="B331D30AC55923A5" modified="2018-04-25" version="1">MDTVPLRDAYRSLMDAAATVAGSGGTMPVPPTGEWNADQILAHVAIVNATTIATVAAASSGAPTTYDNRTAHDTWTIERVIGLAGDNAGLRERIRLQADALCALAGPMLSETELDTLVPTLLLSHDKVQVNQPLPLRDLVTGLTEVELPGHTRQLLSLMPPSAAGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-09-29" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JYW3</accession>
    <name>A0A2M9JYW3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Calcineurin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_14860</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN12072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN12072">
        <property type="protein sequence ID" value="PJN12072"/>
        <property type="gene ID" value="CG723_14860"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP_ApaH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="SSF56300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Metallophos" evidence="1">
        <location>
            <begin position="96"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN12072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="409" mass="43204" checksum="36682DBF8E261018" modified="2018-04-25" version="1">MCDDEYIPPRPDLTESQWLDLDTTITTTGRPAPTAGGPSGLVGRRTVLGGAVAGAAALAALPQAAAASPRSATAADAPVAKFPFPGRPGRGGQYAVLLTGDAGTGDEAQYAVATAAKAICRTEGVSLAVGLGDNLYENGPESAHDDEFATKFEQPNDGIDVPWLMVLGNHDCSGLIPGSGGDPSRGDREVAYATTSRRWHMPARYYSTALPSAADPDVPLVEFFAIDTNPIASTVTQLDPYFQWNGPYMREQRRWLDSALSASRATWKIVVGHHPYLNNGKHGSAGSYDGFVIGNYTSGIHLKELYEEVVCGRADLILSGHDHTQQILEPTARSRGTRQIVCGTAGKSGDGKTHGTHPARWQDFSHNGFMVLKASAKSLTIDAYTVDAATSTSSLAHSFTTMSALTAAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-05-25" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JZD2</accession>
    <name>A0A2M9JZD2_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Putative 4-hydroxy-4-methyl-2-oxoglutarate aldolase</fullName>
            <ecNumber evidence="5">4.1.1.112</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Oxaloacetate decarboxylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Regulator of ribonuclease activity homolog</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">RraA-like protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CG723_09460</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">CB01635</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2-oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>H(+) + oxaloacetate = CO2 + pyruvate</text>
            <dbReference type="Rhea" id="RHEA:15641"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16452"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="EC" id="4.1.1.112"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homotrimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the class II aldolase/RraA-like family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.112" evidence="5"/>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN12117.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN12117">
        <property type="protein sequence ID" value="PJN12117"/>
        <property type="gene ID" value="CG723_09460"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008948">
        <property type="term" value="F:oxaloacetate decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd16841">
        <property type="entry name" value="RraA_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005493">
        <property type="entry name" value="RraA/RraA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036704">
        <property type="entry name" value="RraA/RraA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03737">
        <property type="entry name" value="RraA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="SSF48179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89562">
        <property type="entry name" value="SSF89562"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="334"/>
            <end position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008621"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00016549"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00029596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00030169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00032305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PJN12117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="353" mass="36201" checksum="EBD7052E31B725FD" modified="2018-04-25" version="1">MIGSVPTYRHRTALVTSGPGATVVADYFGAIGAPVEDLGGEPGAASARKLLRSVFMKGLGAVITQTVEAGRSAGDELWVRGQIAAELAGGESTLQRLYAGTAKHGARRAFEVSAAADLMADLDLDAELTRAISHVHTLAARPEGLRDVPQVTDELLAAHRDVATANIGDAVDRLALLDSGIRPLWPGARAIGRALTVWTRAGDNRAIHEAIKIAAPGDFIVVNGEGDTSRALIGELIAERAKARGVVGMVLDGAARDIDVLAEIGFPVWARAVTPAGPYKFGPGHVNVPVALGGLVCRPGDLVVADSDGVAVVASDQAESVLAAARAVEADEAGRRAQIRATAGSTTGTGDAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JZI0</accession>
    <name>A0A2M9JZI0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Multidrug ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CG723_04220</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000002">
        <property type="protein sequence ID" value="PJN12274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN12274">
        <property type="protein sequence ID" value="PJN12274"/>
        <property type="gene ID" value="CG723_04220"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221">
        <property type="entry name" value="PTHR24221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="SSF90123"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="37"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="116"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="199"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="10">
        <location>
            <begin position="40"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="9">
        <location>
            <begin position="397"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="430"/>
            <end position="437"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PJN12274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="642" mass="69268" checksum="4BB3F6D3903908BE" modified="2018-04-25" version="1">MAGPGGRMMGGGGPDQRSMDFKGSGKRLIRQFRPEKTTMLAMVACVVLSVGLSVLGPKILGRATDLVFAGIIGREMPSGSSKAQVIAGMRAKGDSGVADMLSGIDFTPGQGIDFDAVGSVLGLALCTFLGAGLLMAVATRLSNRALNKTVFRMREDIQAKLSRLPLSYFDKRQRGEVLSRATNDIDNIGQTLQQTMGQLINSLLTIIGVLVMMFWISPLLALVALVTVPLSFLIATRVGKRSQPQFVQQWKTTGKLNAHIEEMYTGHTLVKVFGRQEESAKAFAEQNDALYEAGFKAQFNSGMMQPLMFFVSNLNYVLVAVVGGLRVASGSLSIGDVQAFIQYSRQFSMPLTQVASMANLVQSGVASAERIFELLDADEQEADPVPSEKPDLLRGLVEFENVSFRYEQDKPLIEDLSLAVEPGHTVAIVGPTGAGKTTLVNLLLRFYEVTGGRITLDGVDVAKMSRDELRSGIGMVLQDTWLFGGTIADNIAYGATKDVTREQIEEAARAAHADRFIRTLPEGYDTVIDDEGAGVSAGEKQLITIARAFLSDPVILVLDEATSSVDTRTEVLIQTAMARLAHGRTSFVIAHRLSTIRDADTILVMENGDIVEQGTHEALRAAGGAYERLYNAQFAQAVAEVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-09-29" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JZW5</accession>
    <name>A0A2M9JZW5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Nonspecific lipid-transfer protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CG723_05090</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CB01635</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the thiolase-like superfamily. Thiolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000002">
        <property type="protein sequence ID" value="PJN12421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN12421">
        <property type="protein sequence ID" value="PJN12421"/>
        <property type="gene ID" value="CG723_05090"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002155">
        <property type="entry name" value="Thiolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020615">
        <property type="entry name" value="Thiolase_acyl_enz_int_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020617">
        <property type="entry name" value="Thiolase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020613">
        <property type="entry name" value="Thiolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020616">
        <property type="entry name" value="Thiolase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02803">
        <property type="entry name" value="Thiolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00108">
        <property type="entry name" value="Thiolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000429">
        <property type="entry name" value="Ac-CoA_Ac_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00098">
        <property type="entry name" value="THIOLASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00737">
        <property type="entry name" value="THIOLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Thiolase_N" evidence="4">
        <location>
            <begin position="5"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="domain" description="Thiolase_C" evidence="5">
        <location>
            <begin position="274"/>
            <end position="381"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PJN12421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="397" mass="41814" checksum="EA7065EBFB2EB57A" modified="2018-04-25" version="1">MGKAYIVGVGMTRFEKPESRDWQYWDMAKEAGTKALDDAGISYEDVEQVPVGYCFQASTAGQRAVYELGLTGIPVYNVNNNCATGSSALMLARQFVEGGLNDCVLALGFEKMQRGALGGGADGGDFKTSPVARHYGIMAAKHGFEMSPPTAQIFGDAAREHMERYGTTEAQLAAVGAKNHRHSVNNPYAQFQDPYTVDEILAAKTIHAPLTKLQCSPTSDGAAAAVVVSERFVELHDLGDKAVEIAAQAMTTDTGESFASGSCIDVVGQPMSRAAATRVYEDSGLGIEDVDVIELHDCFSVNELLTYEALGMCAPGASGKLVEEGATTYGGRWVVNPSGGLISKGHPLGATGIAQAAELTWQLRGEAGARQVADARVGLAHNIGLGGAAVVTMLRRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K023</accession>
    <name>A0A2M9K023_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CG723_05445</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000002">
        <property type="protein sequence ID" value="PJN12481.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN12481">
        <property type="protein sequence ID" value="PJN12481"/>
        <property type="gene ID" value="CG723_05445"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PJN12481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="82" mass="9120" checksum="F721D271FDE92A86" modified="2018-04-25" version="1">MAEPLKTLVDGVEVEVPNSIPAIRDALPEHRREEFDREINAAGVHEIHAVMRHWMLESVPDPAADAIMDRLAREEAERAGAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K0C8</accession>
    <name>A0A2M9K0C8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Serine protease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CG723_05420</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CB01635</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000002">
        <property type="protein sequence ID" value="PJN12477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN12477">
        <property type="protein sequence ID" value="PJN12477"/>
        <property type="gene ID" value="CG723_05420"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04056">
        <property type="entry name" value="Peptidases_S53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11377">
        <property type="entry name" value="Pro-peptidase_S53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000209">
        <property type="entry name" value="Peptidase_S8/S53_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023828">
        <property type="entry name" value="Peptidase_S8_Ser-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015366">
        <property type="entry name" value="S53_propep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030400">
        <property type="entry name" value="Sedolisin_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00082">
        <property type="entry name" value="Peptidase_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09286">
        <property type="entry name" value="Pro-kuma_activ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00944">
        <property type="entry name" value="Pro-kuma_activ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="SSF52743"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51695">
        <property type="entry name" value="SEDOLISIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00138">
        <property type="entry name" value="SUBTILASE_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0106">Calcium</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 9" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0720">Serine protease</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014909418" evidence="7">
        <location>
            <begin position="35"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S53" evidence="8">
        <location>
            <begin position="240"/>
            <end position="648"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PJN12477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="648" mass="66830" checksum="AB50A0E97BC42FA7" modified="2018-04-25" version="1">MRSTRAAARAGLSLAATLPLLAGALAIAAPVAQADPNPGARDALTGTKPLWATAKADQGAASNSSTVHARVYLAGRDAAGLAAYAKAVSDPQSASYGKHLSAKQAQARFGATKAQIAEVTKWLESSGLTVTDVSKHYISVSGEVAAAEKAFGAQLHNYAKGKHTYRAPTAAATVPASLNGAVLTVTGLDSAPHKADHDETLPPPDAVFHNAGPFSSYYGSKTASTQPSAYGQKAPYAVKGYTGKQLRAAYGAGKKTGKGVRVAITDAYASPTIAKDAATYAKRNGDAAYRSGQLKQVLPADYTKTEECGASGWYGEETLDVEAVHAVAPAADITYVGAASCYDDALLDSLGKIVDGHLADIVSNSWGDIEANQTPDLAAAYDQIFQYGAIEGIGFYFSSGDNGDEVANTGTKQVDVPANSAWVTSVGGTSLAVGKGDKYQFETGWGTLKANLSADGKSWDAFPGAYTSGAGGGTSKTVKQPFYQSGVVPNSLARANGGSQKMRTVPDISAVADPNTGFLVGQSQTFPDGSLKYDEYRIGGTSLAAPVIAGVQALVQEARGGHALGFANPAIYDRFGSKIYHDVTDKPTGRDLAVVRVDYANGFDSADGLLTSLRSLGKDSSLKAVRGYDDVTGVGSPAPGYVTSFGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K0S2</accession>
    <name>A0A2M9K0S2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DUF58 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_06185</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000002">
        <property type="protein sequence ID" value="PJN12617.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN12617">
        <property type="protein sequence ID" value="PJN12617"/>
        <property type="gene ID" value="CG723_06185"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002881">
        <property type="entry name" value="DUF58"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01882">
        <property type="entry name" value="DUF58"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="27"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="50"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="domain" description="DUF58" evidence="2">
        <location>
            <begin position="217"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN12617.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="449" mass="48470" checksum="07EBA2414AE08607" modified="2018-04-25" version="1">MADGGGFGGDDDKGGLRVALSGLTTRGRSFLAAGIAAAICAYVLGQADLLRVGLLLAVLPLVCAFVLYRTRYRVSSSRRLSPARVPAGSEARVHLRMDNVSRLPTGLLMLQDRVPYVLGPRPRFVLDRVEAGGRREVSYRVRSDLRGRYPLGPLQLRLTDPFGLCELSRSFSTYDTLTVIPRVESLPAVRLTGEAKGYGDGRNRSLALAGEDDVIPRGYRYGDDLRRVHWRSTARYGELMVRREEQPQRARCTVLLDTRRLAFQGAGPDSAFEWAVSGTASTLFHMLERGFSVRLLTDTGTSVPGEGSDGFAGASQESADAAGLMMDTLAVVDHSDGSGLSRAYDMLRGGNEGLLVAFFGDLDEEQTAVAAKMRQRSGGAVAFVLDSGAWTRGAPSERCEERLRMLREAGWSALAVPPGTSLTELWRDADRHRAATGAESGPAVAGWGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K1G3</accession>
    <name>A0A2M9K1G3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_04330</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000002">
        <property type="protein sequence ID" value="PJN12959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN12959">
        <property type="protein sequence ID" value="PJN12959"/>
        <property type="gene ID" value="CG723_04330"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="43"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="73"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="105"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="134"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="172"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="211"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="237"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="269"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="289"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="294"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN12959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="309" mass="32284" checksum="252DB09699584DB8" modified="2018-04-25" version="1">MWWGVGAALLANVLYSTGFVLEKRALAALPQISVRRPAHLVRLVAGSPLWLGGSLALAAGFGAQLAVYRTLPIAAAQAIFVSGLVLLLLLSSALLGERTTGRERYAIGAILAALLMVVLSLRQGSDTVSKGAPAALILGVCVPTLAAGLLLYGLAERRTRRRHRLPTTGVEYGVAVGLLYGVSSLAIKGVAGYLTTDRLGAAALHLLTSPYPYLLLCTGGFGLVMSQAALQRCRASLIVPVCSTVTCLFTAVLGTLAFGESLPREPVALALRLTGTLLAVSVLLLMPKHDDPPPHTPSPAKELADREAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K1J2</accession>
    <name>A0A2M9K1J2_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NlpC/P60 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CG723_05955</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CB01635</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C40 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000002">
        <property type="protein sequence ID" value="PJN12994.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN12994">
        <property type="protein sequence ID" value="PJN12994"/>
        <property type="gene ID" value="CG723_05955"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000064">
        <property type="entry name" value="NLP_P60_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00877">
        <property type="entry name" value="NLPC_P60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="SSF54001"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51935">
        <property type="entry name" value="NLPC_P60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014696122" description="NlpC/P60 domain-containing protein" evidence="3">
        <location>
            <begin position="36"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="domain" description="NlpC/P60" evidence="4">
        <location>
            <begin position="227"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="41"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="143"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PJN12994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="343" mass="36598" checksum="16D0738ABCB6D5FB" modified="2018-04-25" version="1">MASHRRPKQPSRTRVTVLTATAAAAVALTSQAAQAAPKPSKSEVKAKVDKLYEEAEKATDKYNGAKEKQKKLEKEIGDLQDKVARGQEDLNEMRTGLGSMASAQYRSGGIDPSVQLFLSADPDDFLDKASTLDQLTGQQVEGLKKIQEKQRSLAQERQEAADKLKDLADTRTELGKKKQQVQSKLSAAQKLLNTLTAAERQKMAADDARASRSAGARVDLGNEVPASKRGAAALSAAATQLGKPYVSGGTGPNSYDCSGLTQWSYGQAGVGITRTTYTQQNDGTKIGMSQLKPGDLVFFNNLAHVGLYAGNGQVLHAPHPGAVVRYESMSTVGSFQFGVRLSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K1R8</accession>
    <name>A0A2M9K1R8_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Histidine kinase</fullName>
            <ecNumber evidence="3">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CG723_00205</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CB01635</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="3"/>
    <dbReference type="EMBL" id="NNBL01000001">
        <property type="protein sequence ID" value="PJN13065.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN13065">
        <property type="protein sequence ID" value="PJN13065"/>
        <property type="gene ID" value="CG723_00205"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00672">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00304">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 11" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014702590" description="Histidine kinase" evidence="8">
        <location>
            <begin position="32"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="172"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="10">
        <location>
            <begin position="196"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="9">
        <location>
            <begin position="257"/>
            <end position="465"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PJN13065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="468" mass="50619" checksum="66AD6883726256AC" modified="2018-04-25" version="1">MRARLLPLLIVLMAGVLLALGFPLAASVAAAQQQKVVVDRIDDTARFAALAQFVTKRSTGSRVRVTDERQQTLQNELTRYYEVYGIRAGVFYRNSDPMGRAPDDWQLPRDGAVREAFDEALFSRGSHDPQQVWPWRRGRLVVASPVISDGDVVAVVVTDSPTGKMRSKTLQGWLLIAAGEAAAMLLAVGAALRLTGWVLRPVRVLDATTHDIATGRLKSRVASAGGPPELQRLARSFNEMADNVEDVLEQQRAFVADASHQLRNPLAALLLRIELLAFELPEGNEEIASVRTEGKRLASVLDDLLDLALAEHTEADLRLTDIGELVTERVGAWRPVADEKGVRLTGDCPAVTGWADPVTLSSALDAVIDNALKFTPSGEEVRVCVARNGESTEIVVADRGPGLREDELARIGDRFWRSAGHQNVKGSGLGLSISRALLAAGGGSITYAPHEPHGLCVTVAVPRTHREG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K1Y9</accession>
    <name>A0A2M9K1Y9_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Histidine kinase</fullName>
            <ecNumber evidence="4">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CG723_00645</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CB01635</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="4"/>
    <dbReference type="EMBL" id="NNBL01000001">
        <property type="protein sequence ID" value="PJN13144.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN13144">
        <property type="protein sequence ID" value="PJN13144"/>
        <property type="gene ID" value="CG723_00645"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038318">
        <property type="entry name" value="KdpD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025201">
        <property type="entry name" value="KdpD_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003852">
        <property type="entry name" value="Sig_transdc_His_kinase_KdpD_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006016">
        <property type="entry name" value="UspA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13493">
        <property type="entry name" value="DUF4118"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02702">
        <property type="entry name" value="KdpD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00582">
        <property type="entry name" value="Usp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7 11" id="KW-0418">Kinase</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="380"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="410"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="459"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="10">
        <location>
            <begin position="621"/>
            <end position="832"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="831"/>
            <end position="851"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PJN13144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="851" mass="91179" checksum="F6EE680E4A35F031" modified="2018-04-25" version="1">MGRGKLRIYLGAAPGVGKTYAMLSEGHRRIERGTDCAVGFVEHHGRPRTEVMLHGLEQISRKELTYRGAVFTEMDVDAVLARHPDVALVDELAHTNVPGSRNAKRWQDVEELLAAGIDVVSTVNIQHLESLGDVVESITGVRQRETVPDEVVRRADQIELVDMSPQALRRRMAHGNIYKPDRIDASLSNYFRPGNLTALRELALLWVADRVDEYLQQYRGEHNIRSTWQARERIVVGLTGGPEGRTLVRRAARMAAKGSGSEILAVYIARSDGLTAASPKELTLQRTLVEDLGGTFHHVIGDDIPAALLEFARGVNATQIVLGSSRRKTWQYIFGPGVGMTVARESGPDLDVHIVTHEEVAKGRGLPVARGARLGRSRIIWGWLVGVGGPALLALALTHVATDLGLANDMLLFLSVTVAAALVGGLLPALASAAVGSLLLNYYFTPPLHLFTVADPKNIVAIVIFVGVAVSVASVVDLAARRTHQAARLRAESEILSFLAGSVLRGEDSLDALLDRVRETFAMDSVALLERAGDVEPWTCAASVGPHPQERPEDADVDMPVGDHMALALSGRVLPAEDRRVLAAFAAQAAVVLDRQRLQSEADQARTLAEGNRIRTALLAAVSHDLRTPLAGIKASVSSLRSDDVAWSEEDQAELLAGIEEGADRLDHLVGNLLDMSRLQTGTVTPLMREIDLDEVVPMALVGVPDGSVDLDIPESLPMVTVDKGLLERAVANIVENAVKYSPEDETVLVAASTLGDRVEVRVVDRGPGVPDTAKDRIFAPFQRYGDAPRGAGVGLGLAVARGFVEAMNGTLTAEDTPGGGLTMVLTLTAASGHPPAGPTSSAIAQRGRYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K257</accession>
    <name>A0A2M9K257_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Methyltransferase type 11</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CG723_00755</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000001">
        <property type="protein sequence ID" value="PJN13160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN13160">
        <property type="protein sequence ID" value="PJN13160"/>
        <property type="gene ID" value="CG723_00755"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044992">
        <property type="entry name" value="ChyE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017926">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42695">
        <property type="entry name" value="PTHR42695"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00117">
        <property type="entry name" value="GATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GATase" evidence="2">
        <location>
            <begin position="12"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="domain" description="Methyltransf_11" evidence="3">
        <location>
            <begin position="270"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="376"/>
            <end position="395"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PJN13160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="428" mass="44598" checksum="7344AF13DD18A585" modified="2018-04-25" version="1">MVQHVREEGPYAIGEALVAAGLRLRVCRVWAGDPLPESLARVEALVVTGGPLAAHSDAGFPARRAELALLREALAAEVPVLGVGLGARLLAVAAGGAARTGAGSQLRWGEVRTGPAADRDPLFAGAPERLRVPHRHGGTMELPDGAALLASCERNPVQAFRVGGSAWGLQFHLEVDEVPVDAFVTACPEEAATAPGIRDAASGEPAEPAAYRDLVFGRFAALVAARAAHTATRTFFTPRADAWEARFAADGPRYAAAVARMGLLPGQTALDLGCGSGRALPALRAGVGDKGKVFGVDVTSAMLTAAAREGRAGPACLLVADCHRLPLPPGATHGIFSAGLLDHLPAPPVALREWARVTASGGTLLLFHPSGRAERAARHGRPLSPDDPLGEPNLRPMLDGNGWQLVCYEDKSEYFLARAVRVADEVHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K2C6</accession>
    <name>A0A2M9K2C6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Metallophosphoesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_01450</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000001">
        <property type="protein sequence ID" value="PJN13279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN13279">
        <property type="protein sequence ID" value="PJN13279"/>
        <property type="gene ID" value="CG723_01450"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004115">
        <property type="term" value="F:3',5'-cyclic-AMP phosphodiesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP_ApaH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="SSF56300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Metallophos" evidence="2">
        <location>
            <begin position="4"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="62"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN13279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="265" mass="28306" checksum="FEFDC2B9C7E3E660" modified="2018-04-25" version="1">MLVLAQISDLHLDGTPRATARARRVIDHLRALPGPFDALLVTGDIADHGAESEYEEAAELLGLHTGGPSDGGPPPPGAPFPGLPFPVLTCPGNHDSRAPYRKALLREPAAEGPVNHAHHVGGAVVLMCDSSIPGADEGRLDEETYGWLEDTLDGLDGETPVLLAFHHPPVALHHPLPDAYQLDRPRELAALLERRPEIAGIIAGHAHTPAATVFAGRPLVIGPGVTWTLRLPWEGEGVADRDAPVGLAFHILDDERRLTTHFRVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-06-02" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K2F6</accession>
    <name>A0A2M9K2F6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Sulfate ABC transporter substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_01645</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000001">
        <property type="protein sequence ID" value="PJN13309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN13309">
        <property type="protein sequence ID" value="PJN13309"/>
        <property type="gene ID" value="CG723_01645"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042626">
        <property type="term" value="F:ATPase-coupled transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd13553">
        <property type="entry name" value="PBP2_NrtA_CpmA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010067">
        <property type="entry name" value="ABC_SsuA_sub-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044527">
        <property type="entry name" value="NrtA/CpmA_ABC-bd_dom"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01728">
        <property type="entry name" value="SsuA_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014838486" evidence="1">
        <location>
            <begin position="35"/>
            <end position="371"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN13309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="371" mass="38651" checksum="E46F83984D4E21B8" modified="2018-04-25" version="1">MPANSSSWRRGLAAVAALPLLALAATACGYGSDAKDDTSGKTNVAAKGKKLSADTVKIGYFGNLTHGTALVGNQKGFFQKELQGTQAKYQTFNAGPSEIEALNGGSIDIGWIGPSPSINGFTKSQGKSLRIIGGSASGGVKLVVNPKKIKSLDDVKGKKIATPQLGNTQDVAFLNWIAEKGWKVDANSGKGDVSVIRTDNKITPDAYKSGSVDGAWVPEPTASKLVAEGGKVLLDESDLWPDKKFVITNIIVSQKFLKEHPDVVEAVLRGSVKTNAWINANPDEAKAAANKQLAADSGKALPANVLDPAWKSIQFTDDPLASTLGTEAAHAVKAGLLEKPDLKGIYDLAPLNKVLKAEGKGAVADAGLGVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K2G0</accession>
    <name>A0A2M9K2G0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF4440 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_01615</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000001">
        <property type="protein sequence ID" value="PJN13303.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN13303">
        <property type="protein sequence ID" value="PJN13303"/>
        <property type="gene ID" value="CG723_01615"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027843">
        <property type="entry name" value="DUF4440"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14534">
        <property type="entry name" value="DUF4440"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="SSF54427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4440" evidence="1">
        <location>
            <begin position="14"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN13303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="121" mass="13500" checksum="EB8652C5E3EFA23F" modified="2018-04-25" version="1">MPELDAVDAAIEGELRLLDPAVRRSPELLGALLHPDYFEFGVSGRRWDRASIITELSSTAELGVRPLTVSRMKGVRLGPGLVHLTFDTDRNGACAHRSSLWRQGVEGWLLYFHQGTPFSRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K2N3</accession>
    <name>A0A2M9K2N3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Helix-turn-helix transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CG723_02085</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000001">
        <property type="protein sequence ID" value="PJN13388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN13388">
        <property type="protein sequence ID" value="PJN13388"/>
        <property type="gene ID" value="CG723_02085"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH luxR-type" evidence="4">
        <location>
            <begin position="230"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PJN13388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="298" mass="29843" checksum="7E3ECD60C54812FC" modified="2018-04-25" version="1">MSADGADAVEMRAALVRLRRGTGLPVAFGGLMTGGTVTGGTGSVRIGELSGAVTGALRGLAIATGNGLGGKALALSRPCAVTDYPVSRHISHEYDAAVAAEGLLSVLAVPVVVRRRVRGVLYGALRTAQPLGDRTLGEAVAAARDVEQALVIRDEARALLAAVGGAGASGSGAGGAAGSVTGASAGSAAWEEVREAHGALRALAPRVVDPALREELLAVCGRLASATAPPHVRDVGLAPREVDVLACVATGATNAATAERLGLRPETVKGYLRSAMRKLGAHTRLEAVVAARRAGLLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K374</accession>
    <name>A0A2M9K374_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Alkaline phosphatase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CG723_03155</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000001">
        <property type="protein sequence ID" value="PJN13573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN13573">
        <property type="protein sequence ID" value="PJN13573"/>
        <property type="gene ID" value="CG723_03155"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002591">
        <property type="entry name" value="Phosphodiest/P_Trfase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01663">
        <property type="entry name" value="Phosphodiest"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="SSF53649"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PJN13573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="474" mass="52493" checksum="3C6C20505D6B98E9" modified="2018-04-25" version="1">MTTAGTDTTSDRSDVSPNPLLVLDVVGLTPRLLDHMPHLKALGRTGSQAHLGTVLPAVTCAAQSTFLTGTMPSEHGIVANGWYFRELGDVLLWRQHNGLVAGDKLWDAARRSHPGYTVANICWWYAMGADTDITVTPRPVYYADGRKEPDCYTRPPALHDELTEKLGTFPLFHFWGPGADLVSSRWIVDATRHIMATRHPDLALAYVPHLDYDLQRFGPDDPRSHRAAAELDATLAPLLDDAKAEGRTVVALSEYGITRVERPVDINRVLRRAGLLEVHTQDGMEYLDPMTSRAFAVADHQIAHIYVRRPEDLDTVREALKDVPGIEQLLDDEGKKAHHLDHPRSGELVAVAEPDAWFTYYYWLDDDRAPDFAQLVEIHRKPGYDPVELFMDPQDPYVKVKAAGALARKKLGMRYRMAVVPLDPSPIRGSHGRLPLSDDSPDGPLILCSTPRAVTGRVAATDVKSLLLDLAGLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K3I4</accession>
    <name>A0A2M9K3I4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CG723_03890</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000001">
        <property type="protein sequence ID" value="PJN13691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN13691">
        <property type="protein sequence ID" value="PJN13691"/>
        <property type="gene ID" value="CG723_03890"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016624">
        <property type="entry name" value="UCP014753"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35339">
        <property type="entry name" value="PTHR35339"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10022">
        <property type="entry name" value="DUF2264"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF014753">
        <property type="entry name" value="UCP014753"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PJN13691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="638" mass="69675" checksum="5C35494B21DEC1F1" modified="2018-04-25" version="1">MPAPHLSLPPTDRVLSPLTGWTRAHWEALADRQLEALVPYATPGFAQYRLPGRASWSGVVSDGLEGFARSFLLASFRIAGAGGNVDPRLVERYAEGLTTGTNRGRGTGLDGEAWPELTDCSQQMVEAASIAIGLHETRPWIWDKLDSRVQERIVDWFSGFVGGRTWDNNWRLFQVVSEQFLASVGAPYSQDDIDGGLDRIEDWYVGDGWYTDGDGRNFDYYIGWAMHLYPLLWARMAGPDGDGGRAKVYRERLSQFLTTYPHFFGGDGAPVHQGRSLTYRFAATAPVWMGALADCTPLEPGLTRRLASGTARHFVERGVPDERGLLPLGWYGTFLPTTQAYSGPASPYWASKGFLGLLLPADHPVWTEREAQLPVEKSERAIQYTALPAPGWLLHGTPHDGIVRLINHGSDHNPLEGPATDDPHYAKLAYSTATAPESAPHAWKRTVDNHVALVAEDGTPSRRRRIHPISCEGRAASSRHDAQLPGFDEEFPIESTTVLHGPWEIRVHRVQAPAGVTVREGGYAVADETSVHAERGPGWALTRTESGMTSAVVALHGWDEESGIAREVEANAYGPHSATPYLRSTGHPGGSSVHVTLAVLTRDVVHPQALRESISCVADPGDDGQVRITFPDGGTVTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K3Q3</accession>
    <name>A0A2M9K3Q3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glutamine amidotransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_03675</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000001">
        <property type="protein sequence ID" value="PJN13657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN13657">
        <property type="protein sequence ID" value="PJN13657"/>
        <property type="gene ID" value="CG723_03675"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002818">
        <property type="entry name" value="DJ-1/PfpI"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01965">
        <property type="entry name" value="DJ-1_PfpI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DJ-1_PfpI" evidence="1">
        <location>
            <begin position="1"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN13657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="211" mass="22393" checksum="56FD091EFA7D16DC" modified="2018-04-25" version="1">MKIAIVLFDRFTALDAVGPYETLGRLPDAELTFVAERTGPVRSDTGRLALTADKTLSELTDPDIVIVPGGPGQSAQMENEVLLDWLRAVDATSTWTTSVCTGSLLLAAAGLLDGRRATSHWLALDALKTFGVEPTGERVVVDGKYVTAAGVSSGIDMGLTLVGTIAGDEHAQAVQLLTEYDPQPPYDAGSPEKAPAHLVEKFRAESRFLQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-09-29" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K3V9</accession>
    <name>A0A2M9K3V9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_03990</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000001">
        <property type="protein sequence ID" value="PJN13814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN13814">
        <property type="protein sequence ID" value="PJN13814"/>
        <property type="gene ID" value="CG723_03990"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="74"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="120"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="250"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="285"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="312"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="338"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="373"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="404"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="436"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN13814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="455" mass="46624" checksum="D4A220BB486DBCBB" modified="2018-04-25" version="1">MSKEGPRGSGEERERAGDSAGGLIPGPGESRRPRGGIWSRDFGLFFSARAVAKLGDTMLPVALAAGLLQHGYGAGAVGLAMAASVACFAGLVIFGGVFADRFSTRLLMIGADVTRLVTQSLAAVMFFSGHVVLWEICVIGAVNGAASALFQPGVASTVPRLATDVQAANGAIRVAESVAQLAGPAVAGLLVAFASPGVVFAAHAGTYGLSALCLLLLRLPPAQPGTEAIRGSGFRADLVEGWREFRSRTWLWGVIAIWCVLMVAAWGPAVPLIATQVVQEHGPRVYGLVNSALGLGTVIGGVFALRLRPRRMLRAGAVALFGFSLFPATVGAGLGVEWMAAGAVVAGAGMSFWGVMWATSIQTQVPRDVLNRIHAYDVAGSLAMTPVGQALAGPAAGVFGTRHVLLAGGVTTVLVAAALLSVPAIRGLIRVDSTVPGGSPRKAPASREPARRGSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JEH1</accession>
    <name>A0A2M9JEH1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_45605</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000060">
        <property type="protein sequence ID" value="PJN05296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN05296">
        <property type="protein sequence ID" value="PJN05296"/>
        <property type="gene ID" value="CG723_45605"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="15"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN05296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="213" mass="22970" checksum="E00DF60CC074C06B" modified="2018-04-25" version="1">MCPDGSGKIGAVSDATAALVAALIGASAAVLAGGLAIHAALKQVSKSAVTQREQAFWELRRDAYAKALVSYRGFERVAWEFNEAAKTEEVSSLKGLLDKMDNAAYSFEESKAVLDISVPEDSDVARAVRNVNDYITDAMMVVELWYEGSPNPDGWSPRYASSLSKVGDCGSVMVDALRDDLAKDVEPATRSGRTLRDWVPLLRSPRGSRTPQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JFA3</accession>
    <name>A0A2M9JFA3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Sugar kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CG723_44470</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CB01635</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ROK (NagC/XylR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000047">
        <property type="protein sequence ID" value="PJN05502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN05502">
        <property type="protein sequence ID" value="PJN05502"/>
        <property type="gene ID" value="CG723_44470"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000835">
        <property type="entry name" value="HTH_MarR-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000600">
        <property type="entry name" value="ROK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18964">
        <property type="entry name" value="PTHR18964"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12802">
        <property type="entry name" value="MarR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00480">
        <property type="entry name" value="ROK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01125">
        <property type="entry name" value="ROK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="HTH marR-type" evidence="3">
        <location>
            <begin position="31"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PJN05502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="409" mass="42228" checksum="D165B026087DFD16" modified="2018-04-25" version="1">MSDARAARDDGSTDGAPVASGLEWGRLPTAPAVTTVLTEILKRGPIPRIEVAQRTGLSQTAVTKAVARLTEQGLISAHDHRRSAAPGRPVQPLSVQAQAALAIGITVRVDEIFGVATTLRAEVLQSIHRPLASTVPAAVADSVATMIDALLAELGPDAERVLGAGVAVSGEVDSALGIVRTSPRLNWRDVPLRELIHERHGLPVYVDNDVRALSIAEEWFGIGVDTNSFAILTIGAGIGCGLYVNGDVVAGDHGVAGEIGHLPLGPSDLLCTCGRHGCVETVASSSAIIQAIRAAKQDPLLTMREAVALARDGDAEARGAFERAGSVLGLALATVANLVGPGSILVAGESVTNYDLFGVRLREAFEAHAFGSAGDCTIVAKSHTFEDWARGSAASAIQALVEGKLAAQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JFT0</accession>
    <name>A0A2M9JFT0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Amino acid ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CG723_42730</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CB01635</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000041">
        <property type="protein sequence ID" value="PJN05755.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN05755">
        <property type="protein sequence ID" value="PJN05755"/>
        <property type="gene ID" value="CG723_42730"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071705">
        <property type="term" value="P:nitrogen compound transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010065">
        <property type="entry name" value="AA_ABC_transptr_permease_3TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01726">
        <property type="entry name" value="HEQRo_perm_3TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="38"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="85"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="115"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="155"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="263"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="79"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PJN05755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="298" mass="32510" checksum="031632AC773B0529" modified="2018-04-25" version="1">MSLTSDPPIDRTTSATTAGGAVDYGALKVVPVRHPWRWAAIVATAVLLAQFAHGFITNTGWEWGVFTDYFTADVILKAVWTTLQLTFYGTALGFALGIVLAFMRLSASRFLQAVAFGYIWAFRSIPLIVQLLFWFNLAYLYKELQFGIPFGPGFLSFDTMGLVGAMSAAVLGLALHQAAYAAEIVRGGVLAVDGGQLEAAAALGIPRLRQIRRIVLPQAMRSILPNAANEVISLFKGTSIVSVMAIGELFYQVQVIYGRNGRVVPLLMVATVWYVLLTSALSVLQHYVERHFSKGTTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JG06</accession>
    <name>A0A2M9JG06_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Prephenate dehydrogenase</fullName>
            <ecNumber evidence="4">1.3.1.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CG723_42830</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CB01635</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>NAD(+) + prephenate = 3-(4-hydroxyphenyl)pyruvate + CO2 + NADH</text>
            <dbReference type="Rhea" id="RHEA:13869"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:29934"/>
            <dbReference type="ChEBI" id="CHEBI:36242"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.3.1.12"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-tyrosine biosynthesis; (4-hydroxyphenyl)pyruvate from prephenate (NAD(+) route): step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the prephenate/arogenate dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.12" evidence="4"/>
    <dbReference type="EMBL" id="NNBL01000041">
        <property type="protein sequence ID" value="PJN05772.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN05772">
        <property type="protein sequence ID" value="PJN05772"/>
        <property type="gene ID" value="CG723_42830"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00122">
        <property type="reaction ID" value="UER00961"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008977">
        <property type="term" value="F:prephenate dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004665">
        <property type="term" value="F:prephenate dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006571">
        <property type="term" value="P:tyrosine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002912">
        <property type="entry name" value="ACT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003099">
        <property type="entry name" value="Prephen_DH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02153">
        <property type="entry name" value="PDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="SSF48179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51671">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51176">
        <property type="entry name" value="PDH_ADH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0827">Tyrosine biosynthesis</keyword>
    <feature type="domain" description="Prephenate/arogenate dehydrogenase" evidence="7">
        <location>
            <begin position="2"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="domain" description="ACT" evidence="8">
        <location>
            <begin position="294"/>
            <end position="361"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00016891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PJN05772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="361" mass="37535" checksum="82515DD2044C2885" modified="2018-04-25" version="1">MRTALVIGTGLIGTSAAQALASRGVHVHLADHDPTQARTAAALGAGTDEAPEGPVDLCLVAVPPAHVATTLADAMRRGVARGYLDVASVKGGPRRDLEALGLDLSPYIGTHPMSGRERSGPLAATADLFEGRPWVLTPTRDTDTEVLNLALELVALCRAVPVVMDADAHDRAVALVSHMPHLVSSMVAARLEHAEESAVRLCGQGIRDVTRIAGSDPRMWIDILSANPGPVADLLSAVSADIDETVSALRSLQSSDEAKRSEGVTGIGEVLRRGNAGQVRVPGKHGAAPAAYDTVAVLISDQPGELARIFADAGAAGVNVEDVRIEHATGQQAGFVQLLVQPAAAPKLTAALRDRGWAMRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JG64</accession>
    <name>A0A2M9JG64_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Teichoic acid ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CG723_42325</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CB01635</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ABC transporter superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000039">
        <property type="protein sequence ID" value="PJN05874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN05874">
        <property type="protein sequence ID" value="PJN05874"/>
        <property type="gene ID" value="CG723_42325"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03220">
        <property type="entry name" value="ABC_KpsT_Wzt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015860">
        <property type="entry name" value="ABC_transpr_TagH-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="43"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="76"/>
            <end position="83"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PJN05874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="278" mass="30014" checksum="7446925C6146ABB1" modified="2018-04-25" version="1">MADTFGERIPTVIVDDVDIVYRVNGTGAGRGTATAALGRIIGGRKKAEARAGVRKVHAVKKVSFTAYKGEAIGLIGTNGSGKSTLLKAVAGLLPTENGRIFTHGQPSLLGVNAALMNDLTGERNVHLGGLAMGMSREEVRERYDDIVGFSGINEKGDFITLPMRTYSSGMAARLRFSIAAAKDHDVLLIDEALATGDRSFQKRSESRIRELRKEAGTVFLVSHNNKSIRDTCDRVLWLERGELRMDGPTDEVLKAYEAFTNPNDGKPEPKKAKVAVSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JGD7</accession>
    <name>A0A2M9JGD7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Flavin reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_41600</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000037">
        <property type="protein sequence ID" value="PJN05944.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN05944">
        <property type="protein sequence ID" value="PJN05944"/>
        <property type="gene ID" value="CG723_41600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016646">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002563">
        <property type="entry name" value="Flavin_Rdtase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01613">
        <property type="entry name" value="Flavin_Reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00903">
        <property type="entry name" value="Flavin_Reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flavin_Reduct" evidence="1">
        <location>
            <begin position="22"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN05944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="168" mass="17397" checksum="3A2F4499263C8F73" modified="2018-04-25" version="1">MTATPDLRIATTASPDLLRSVFRRHAAGVAVITARGAAPVGFTATSLTSVSAEPPVISFGIGLGASSWPVVSEAGHIGVHILGEHQQDLAATFAKSGADRFGGPTRWHEGPEGVPVLEGVLAWLVCRVIARVPAGDHRIVLAEAVAGDPAGTGRPLVYHQGRFNGLRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JGF3</accession>
    <name>A0A2M9JGF3_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Probable succinyl-diaminopimelate desuccinylase</fullName>
            <ecNumber evidence="5">3.5.1.18</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CG723_41710</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CB01635</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>H2O + N-succinyl-(2S,6S)-2,6-diaminoheptanedioate = (2S,6S)-2,6-diaminoheptanedioate + succinate</text>
            <dbReference type="Rhea" id="RHEA:22608"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:57609"/>
            <dbReference type="ChEBI" id="CHEBI:58087"/>
            <dbReference type="EC" id="3.5.1.18"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; LL-2,6-diaminopimelate from (S)-tetrahydrodipicolinate (succinylase route): step 3/3.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.18" evidence="5"/>
    <dbReference type="EMBL" id="NNBL01000037">
        <property type="protein sequence ID" value="PJN05966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN05966">
        <property type="protein sequence ID" value="PJN05966"/>
        <property type="gene ID" value="CG723_41710"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00034">
        <property type="reaction ID" value="UER00021"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009014">
        <property type="term" value="F:succinyl-diaminopimelate desuccinylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009089">
        <property type="term" value="P:lysine biosynthetic process via diaminopimelate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010182">
        <property type="entry name" value="ArgE/DapE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001261">
        <property type="entry name" value="ArgE/DapE_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036264">
        <property type="entry name" value="Bact_exopeptidase_dim_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002933">
        <property type="entry name" value="Peptidase_M20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011650">
        <property type="entry name" value="Peptidase_M20_dimer"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07687">
        <property type="entry name" value="M20_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01546">
        <property type="entry name" value="Peptidase_M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55031">
        <property type="entry name" value="SSF55031"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01910">
        <property type="entry name" value="DapE-ArgE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00758">
        <property type="entry name" value="ARGE_DAPE_CPG2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00759">
        <property type="entry name" value="ARGE_DAPE_CPG2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="M20_dimer" evidence="8">
        <location>
            <begin position="190"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001246"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011921"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00016853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF07687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PJN05966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="411" mass="43295" checksum="4B98D3962B06F29F" modified="2018-04-25" version="1">MRSRPTALPVPVTDAAAAVALTQELVRLRTVNAAGATEVERPAADLLQRLFTEFGWKYEVVEVVPGRPNTVAVVEGGGGDGPTLMFEGHIDVVTEGDTADWTVDPYGAEIRDGKLWGRGSADMKSGVAAMIYGVRALQLAGPFPGRIVVGVLCDEEGLMLGAKAFAASPLAREVDGVIVCEPEGYEVCTSARGGIRLRLDLHGVMAHGAMPQEGRSPIVAGARIVEALAAVQEWAEERYGEHPHAGRVTVTPTVLLGGDPDQLNVIPAHGVVGIDVRTVPGTDHAELIERVKEFAQRAASGVGVSVEVTVVDDRPAIEIPEDHPVVTALVDAHRQVHGEAPPFGAVPGTTDGTILTRDAGLATVVYGPGGKWIAHQADEYVEVREIAEYTRVYAAAAQAFLTARTDGGAER</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JGF6</accession>
    <name>A0A2M9JGF6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_41730</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000037">
        <property type="protein sequence ID" value="PJN05970.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN05970">
        <property type="protein sequence ID" value="PJN05970"/>
        <property type="gene ID" value="CG723_41730"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="90"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="167"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="377"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="555"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="561"/>
            <end position="579"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN05970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="579" mass="60707" checksum="B42669C1E336FAED" modified="2018-04-25" version="1">MSSAETPTPTPTPPPSRPRQIRRLPLAGVLRLNKPSDIWFKPATSVVVSAAVPNLTLLALGRLDLAMYTMAGSLCALYAHNLPYAARARALAWVVLGMLASLAVALFTASLTSSAAVLVAVGALLAAAQKTLCDATRIGPPGHLILTFISSASLFAPQYLGQIPGHLALTAGAGAVAWLVGMAPALVRPHGPERRATARALNAAAAYVSAEGGARERARAGAAAAVHAAWQSLLATGDRGAARRALERLVVRAEVALAAPADTDPALLRDWAAGLSGTGPVPRISHAHAHEVDDEVLGVEAELAFGKPSLWRRLAPGSPLLPVALRTAVGCALAGYGSLALGIGRPYWALVTAASLYQANVTLTWNRTVQRVAGNLAGVLVFAAVVPLAHAGQIFVVLFCLLFSFGAEAFISRNYWLGSVCVTPMALLITEFARTQEAGELITDRVVDTLVGALLGIVAAVIVTNRRAADHIELALEATGRAREAAERTLASPRPEPGALETARRRLAAALVELRAADDTAAGEWWQRALPEERVVTAEQAGHRTLAATVRRATPWTVRNPENADEHRGGTDARENTRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JGJ3</accession>
    <name>A0A2M9JGJ3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_41695</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000037">
        <property type="protein sequence ID" value="PJN05963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN05963">
        <property type="protein sequence ID" value="PJN05963"/>
        <property type="gene ID" value="CG723_41695"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021741">
        <property type="entry name" value="DUF3311"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11755">
        <property type="entry name" value="DUF3311"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="43"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="73"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN05963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="115" mass="12355" checksum="A8EC64AC4A1EA763" modified="2018-04-25" version="1">MSPTDEAASRSPEPDPREADLLDSPEPDPLEGLPTLGGQSRRSLWMLLVPVVLYGAAPFVANRIEPRILGVPFLLAWVIAATVVSPVAIWLVARFDPAYRTGAVEPVPVDEGGTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JGU9</accession>
    <name>A0A2M9JGU9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_40920</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000035">
        <property type="protein sequence ID" value="PJN06110.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN06110">
        <property type="protein sequence ID" value="PJN06110"/>
        <property type="gene ID" value="CG723_40920"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN06110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="146" mass="15757" checksum="99D6FCD4E6D3D493" modified="2018-04-25" version="1">MPRATRSLPARRPATPGNADARIAPALPPAFDAFRALHSGCYLGYAQLHLPADEAADAVAHTLGHLLTHWPHVVSQPSPATYAWQQLVAFTASRHHPLPLNTSSPQQYDTVVLHHGLGYPLKAVADSTGLHPAKAAYLARSWRPSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JH88</accession>
    <name>A0A2M9JH88_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Phosphotriesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CG723_40220</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CB01635</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
        <text evidence="2">Binds 2 divalent metal cations per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the metallo-dependent hydrolases superfamily. Phosphotriesterase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000033">
        <property type="protein sequence ID" value="PJN06246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN06246">
        <property type="protein sequence ID" value="PJN06246"/>
        <property type="gene ID" value="CG723_40220"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009056">
        <property type="term" value="P:catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001559">
        <property type="entry name" value="Phosphotriesterase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10819">
        <property type="entry name" value="PTHR10819"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02126">
        <property type="entry name" value="PTE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016839">
        <property type="entry name" value="PhP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51347">
        <property type="entry name" value="PHOSPHOTRIESTERASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="2">
        <location>
            <position position="23"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="25"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" description="via carbamate group" evidence="2">
        <location>
            <position position="132"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="165"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="194"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="251"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="modified residue" description="N6-carboxylysine" evidence="1 3">
        <location>
            <position position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR601559-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR601559-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PJN06246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="306" mass="32332" checksum="72A7DFF5AC813B23" modified="2018-04-25" version="1">MTATVRTVLGDVAPEELGVCDAHDHLFFRSPLLPGQELDDAAAAEAELRAYREAGGGAVVQWTPHGLGRRAELLPELSTTTGVRIVAATGLHQAAHYTPELLDRLRPVLADVFVRELTDGIGDSGVRAGLIKVAGGFHALDAHAVWTMRAAAEAHHATGAPIAVHHELGTGVLDVLDLLCGELGVAPERVVLGHLNRSPDFAVHRQAAESGAYLAFDGPSRANHATDWRMPDAMAALAEAGFGERLLLGGDTTTAGARSVSGGPGMPYLLRRVRPRLELALGKELVDRILVDNPGRAFAVERLPGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JHJ4</accession>
    <name>A0A2M9JHJ4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Actinorhodin polyketide synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CG723_39920</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000032">
        <property type="protein sequence ID" value="PJN06313.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN06313">
        <property type="protein sequence ID" value="PJN06313"/>
        <property type="gene ID" value="CG723_39920"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017000">
        <property type="term" value="P:antibiotic biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901362">
        <property type="term" value="P:organic cyclic compound biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030639">
        <property type="term" value="P:polyketide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="SSF47336"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0045">Antibiotic biosynthesis</keyword>
    <keyword evidence="1 4" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="5">
        <location>
            <begin position="3"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="4">
        <location>
            <position position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PJN06313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="88" mass="9584" checksum="B0F29AC77A4C5B6B" modified="2018-04-25" version="1">MDRLELSDLKTLLRECAGEEEGVDLDGDVIDVTFMELGYDSLALLQTTGRIEREYGISLDEDGLDEAETPRALLALVDRALAAARAVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JHP7</accession>
    <name>A0A2M9JHP7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_39500</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000031">
        <property type="protein sequence ID" value="PJN06401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN06401">
        <property type="protein sequence ID" value="PJN06401"/>
        <property type="gene ID" value="CG723_39500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN06401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="182" mass="19421" checksum="B64046B41E31CE33" modified="2018-04-25" version="1">MTEAPATPAQGPPASETVAEPVPAAQEPGPDPESDAQKTRPVAQEPVPEDPEVTARRREFLRLLGEFRRTAVLVPLGDFPGSEDQRGLLTADFNGIRFILAFSDEQALARYAQARGEFSREWTYRTILGARLLDVAVPAAGVPCGVALDCADGPDGMVFPPVRGIVPDEAAVDRDEGERGSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JI90</accession>
    <name>A0A2M9JI90_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">TetR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_38465</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000028">
        <property type="protein sequence ID" value="PJN06584.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN06584">
        <property type="protein sequence ID" value="PJN06584"/>
        <property type="gene ID" value="CG723_38465"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041347">
        <property type="entry name" value="MftR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17754">
        <property type="entry name" value="TetR_C_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="24"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="47"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN06584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="205" mass="23086" checksum="6D5E786F69773ADE" modified="2018-04-25" version="1">MAPSARSTSAADRPGMGLRERKKLKTRVAIRDATYRLITEQGYDATTVEQIAEAAEVSPSTVFRYFPTKEDIVITDEYDAMLEAELRARPADESIVDSLKHVIAQAVYLGFDDDPEVSRLRTRLQVEVPAVRSRMMESMSVTGQLLCRVIGERTGRDADGLEVRVYAMALVGALMETTLYWAEHGHQEELRDLMDRTLETFRNGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JIC2</accession>
    <name>A0A2M9JIC2_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Tad domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_38290</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000028">
        <property type="protein sequence ID" value="PJN06614.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN06614">
        <property type="protein sequence ID" value="PJN06614"/>
        <property type="gene ID" value="CG723_38290"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028087">
        <property type="entry name" value="Tad_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13400">
        <property type="entry name" value="Tad"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014618162" description="Tad domain-containing protein" evidence="1">
        <location>
            <begin position="25"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="domain" description="Tad" evidence="2">
        <location>
            <begin position="7"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13400"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN06614.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="189" mass="19522" checksum="579E74C6CA28B8AB" modified="2018-04-25" version="1">MPIYIWLTAILLFAAFAFFAFAQAASARNGAQSAADAAALAAAQDSRGELMTGLGKAIGAGDDWLDWLAGDKFTGDGARGAADNLAAGNDARVVGFGPSEVNGYPGYWAKVQSNGTVGDSVIPGTESKHATAEATAVIEPRCDVAPSADPAKVVEFDCDGGDSFDFDPDDFETRDLPDPSVLFSVHLAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JIE7</accession>
    <name>A0A2M9JIE7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Redox-sensitive transcriptional activator SoxR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">soxR</name>
        <name evidence="8" type="ORF">CG723_37960</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000027">
        <property type="protein sequence ID" value="PJN06666.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN06666">
        <property type="protein sequence ID" value="PJN06666"/>
        <property type="gene ID" value="CG723_37960"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01110">
        <property type="entry name" value="HTH_SoxR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000551">
        <property type="entry name" value="MerR-type_HTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010211">
        <property type="entry name" value="Redox-sen_tscrpt-act_SoxR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015358">
        <property type="entry name" value="Tscrpt_reg_MerR_DNA-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30204:SF0">
        <property type="entry name" value="PTHR30204:SF0"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00376">
        <property type="entry name" value="MerR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09278">
        <property type="entry name" value="MerR-DNA-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00040">
        <property type="entry name" value="HTHMERR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00422">
        <property type="entry name" value="HTH_MERR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="SSF46955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01950">
        <property type="entry name" value="SoxR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50937">
        <property type="entry name" value="HTH_MERR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH merR-type" evidence="7">
        <location>
            <begin position="10"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PJN06666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="155" mass="17379" checksum="5FF69165EC73C4E3" modified="2018-04-25" version="1">MPQIPVKIHELAVGQLSARSGAAVSALHFYEAKGLISSRRTTGNQRRYQRDTLRRVAFIRAAQRVGIPLATIRDALSELPEGRTPTREDWAHLSEAWRSELDQRITQLGRLRDHLTDCIGCGCLSLENCVLSNPDDVFGERLTGSRLMRENREGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JIF8</accession>
    <name>A0A2M9JIF8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MarR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_37745</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000027">
        <property type="protein sequence ID" value="PJN06632.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN06632">
        <property type="protein sequence ID" value="PJN06632"/>
        <property type="gene ID" value="CG723_37745"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000835">
        <property type="entry name" value="HTH_MarR-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12802">
        <property type="entry name" value="MarR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00598">
        <property type="entry name" value="HTHMARR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00347">
        <property type="entry name" value="HTH_MARR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50995">
        <property type="entry name" value="HTH_MARR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH marR-type" evidence="1">
        <location>
            <begin position="6"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN06632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="148" mass="15947" checksum="A5723E791E08251E" modified="2018-04-25" version="1">MQNSEAMALSAALLSAAGELTQRIHEGVVARGFEGLRPAHGFAFARLSWDGATATDLAAHLGVTKQAASQLVDELVRKGYAERRPHPDDARARLVVMTERGWACARAAEESAADAVRPWVERLGERKARALLDQLTAVAPDGPIRPAW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JIQ3</accession>
    <name>A0A2M9JIQ3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">NADH-quinone oxidoreductase subunit E</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CG723_37440</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CB01635</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>2Fe-2S cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49601"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the complex I 24 kDa subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000026">
        <property type="protein sequence ID" value="PJN06765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN06765">
        <property type="protein sequence ID" value="PJN06765"/>
        <property type="gene ID" value="CG723_37440"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03064">
        <property type="entry name" value="TRX_Fd_NuoE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1590">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002023">
        <property type="entry name" value="NuoE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042128">
        <property type="entry name" value="NuoE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041921">
        <property type="entry name" value="NuoE_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01958">
        <property type="entry name" value="nuoE_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01099">
        <property type="entry name" value="COMPLEX1_24K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="6" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="236"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="243"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="266"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PJN06765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="292" mass="30811" checksum="55D2BFDBA9B5DE5D" modified="2018-04-25" version="1">MTTTPSEQGQGVSLGMPRLPAPDYPDDVRARLETDAREIIARYPGSRSALLPLLHLVQSEEGHVTRTGMQFCADMLGLTTAEVTAVATFYTMYRRKPSGDYQVGVCTNTLCAVMGGDAIFEALQEHLGVGNGGTTEDGKVTLEHIECNAACDFAPVVMVNWEFFDNQTVGSAKRLVDDLRAGAQVEPTRGAPLCTYKETARILAGFPDERPGAVEASGSAGPASLIGLRLAKGEAAPARVVHPRDGGPHRDADNAAPHDTSPAEHLSSHDAPQDTSSSDPAHPAGPVAEEGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JIQ6</accession>
    <name>A0A2M9JIQ6_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">PLDc_N domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CG723_37255</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CB01635</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000026">
        <property type="protein sequence ID" value="PJN06732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN06732">
        <property type="protein sequence ID" value="PJN06732"/>
        <property type="gene ID" value="CG723_37255"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027379">
        <property type="entry name" value="CLS_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13396">
        <property type="entry name" value="PLDc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="35"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="domain" description="PLDc_N" evidence="7">
        <location>
            <begin position="12"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF13396"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PJN06732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="136" mass="15637" checksum="C399B5A54FBDB0E4" modified="2018-04-25" version="1">MLRYLPFLLVLALWIYAFIDCLNTPEEEVRGLPKVVWVIIILLFGEVLVGPIAWLVAGRHRHAPANGSTPSEWHRSHRTTFVAPDDNPEFLHSLREEAASSEEVKDESLLKDWEADLRRREEELRKREGEQGGEPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-05-25" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JIU4</accession>
    <name>A0A2M9JIU4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">NADH-quinone oxidoreductase subunit L</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CG723_37475</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CB01635</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5">Membrane</location>
            <topology evidence="1 5">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000026">
        <property type="protein sequence ID" value="PJN06772.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN06772">
        <property type="protein sequence ID" value="PJN06772"/>
        <property type="gene ID" value="CG723_37475"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042773">
        <property type="term" value="P:ATP synthesis coupled electron transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018393">
        <property type="entry name" value="NADHpl_OxRdtase_5_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001750">
        <property type="entry name" value="ND/Mrp_mem"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003945">
        <property type="entry name" value="NU5C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001516">
        <property type="entry name" value="Proton_antipo_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42829">
        <property type="entry name" value="PTHR42829"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00361">
        <property type="entry name" value="Proton_antipo_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00662">
        <property type="entry name" value="Proton_antipo_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01974">
        <property type="entry name" value="NDH_I_L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="29"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="86"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="118"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="181"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="209"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="250"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="280"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="374"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="416"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="468"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="507"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="612"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="domain" description="Proton_antipo_N" evidence="8">
        <location>
            <begin position="69"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="Proton_antipo_M" evidence="7">
        <location>
            <begin position="135"/>
            <end position="421"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PJN06772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="633" mass="67429" checksum="FB3B896AABA684B7" modified="2018-04-25" version="1">MENLIALLVAAPLLGAAVLLCGGRRLDRVGHLLGTLLSAASFVIGVLLFADMLGKSADDRTFTQHLFSWIPVEGFQADVSFQLDQLSMTFVLLISGVGTLIHIYSIGYMEHDERRRRFFGYLNLFLAAMLLLVLADNYLLLYVGWEGVGLASYLLIGFWQHKPSAATAAKKAFLVNRVGDMGLSIAIMLMFTTFGTFAFAPVLKAAEEHQGGGATLTGIALMLLLAACGKSAQVPLQSWLGDAMEGPTPVSALIHAATMVTAGVYLIVRSGAVFNASPDAQLVVVIVGAVTLLFGAIVGCAKDDIKKALAGSTMSQIGYMVLAAGLGPIGYVFAIMHLVTHGFFKAGLFLGAGSVMHGMNDEVDMRKYGALRKYMPVTFVTFGLGYLAIIGFPGLSGFFSKDKIIEAAFAKGGTEGWILGSVALLGAAITAYYMTRVMIMTFFGEKRWQPDAEGHEPHPHESPKSMTIPMIVLAVGSVFAGGFFSIGDRFLHWLEPVTEHSHGDAPISATTVTAATMVVLVIGAGLAYLQYARRPVPVVAPRGSLLTRAARRDLLQDDFNHVVLVRGGEHLTRSLVYVDHTLVDGVVNGTAASVGGLSGRLRKLQNGYARSYAVSMFGGAALIVAATLLMRAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JIY9</accession>
    <name>A0A2M9JIY9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">SAM-dependent methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CG723_36795</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CB01635</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CFA/CMAS family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000025">
        <property type="protein sequence ID" value="PJN06844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN06844">
        <property type="protein sequence ID" value="PJN06844"/>
        <property type="gene ID" value="CG723_36795"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008610">
        <property type="term" value="P:lipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003333">
        <property type="entry name" value="Mycolic_cyclopropane_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020803">
        <property type="entry name" value="PKS_MeTfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF003085">
        <property type="entry name" value="CMAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00828">
        <property type="entry name" value="PKS_MT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PKS_MT" evidence="4">
        <location>
            <begin position="158"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="397"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR003085-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PJN06844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="432" mass="48156" checksum="7B3D830754337DEC" modified="2018-04-25" version="1">MQDAAQRLKNLAEQLLGVPLPVRLRAWDGSEAGPPAGPTLVVRNRRALRRLLWKPGELGLARAWVAGDLDVEGDLYDALGRMAGLIWERPEEDSRSLVEALKEPRVRAAVAELVKLAGPFLPPAPPGEEMRRHGRLHLHTKRSDRRAISHHYDVGNDFYELVLGPSMVYSCAYWASPDGTLEDAQRDKLELISRKLGLAPGQRLLDVGCGWGSMAIHAAREYDVSVVGVTLSQEQAAYARKRVAEEGLTDRVEIRVQDYRDVRDGPFDAISSIGMAEHVGSERYLEYAEALYALLKPGGRLLNHQIGRRPQKDESTYEVDEFIDAYVFPDGELAPVGTTTGLLERAGFEVRDLEAIREHYALTLRRWVANLEAAWPAAVKFTSPGRARIWRLYMAACALSFERNKIGVNQILAVKTPLSGDPGMPLRARTWN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JJ14</accession>
    <name>A0A2M9JJ14_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">NADH-quinone oxidoreductase</fullName>
            <ecNumber evidence="9">7.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CG723_37450</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">CB01635</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>a quinone + 5 H(+)(in) + NADH = a quinol + 4 H(+)(out) + NAD(+)</text>
            <dbReference type="Rhea" id="RHEA:57888"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>2Fe-2S cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49601"/>
        </cofactor>
        <text evidence="9">Binds 1 [2Fe-2S] cluster per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 9">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the complex I 75 kDa subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.1.1.-" evidence="9"/>
    <dbReference type="EMBL" id="NNBL01000026">
        <property type="protein sequence ID" value="PJN06767.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN06767">
        <property type="protein sequence ID" value="PJN06767"/>
        <property type="gene ID" value="CG723_37450"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043546">
        <property type="term" value="F:molybdopterin cofactor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042773">
        <property type="term" value="P:ATP synthesis coupled electron transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00207">
        <property type="entry name" value="fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036010">
        <property type="entry name" value="2Fe-2S_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001041">
        <property type="entry name" value="2Fe-2S_ferredoxin-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009010">
        <property type="entry name" value="Asp_de-COase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006657">
        <property type="entry name" value="MoPterin_dinucl-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006656">
        <property type="entry name" value="Mopterin_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006963">
        <property type="entry name" value="Mopterin_OxRdtase_4Fe-4S_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000283">
        <property type="entry name" value="NADH_UbQ_OxRdtase_75kDa_su_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010228">
        <property type="entry name" value="NADH_UbQ_OxRdtase_Gsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019574">
        <property type="entry name" value="NADH_UbQ_OxRdtase_Gsu_4Fe4S-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04879">
        <property type="entry name" value="Molybdop_Fe4S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00384">
        <property type="entry name" value="Molybdopterin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01568">
        <property type="entry name" value="Molydop_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10588">
        <property type="entry name" value="NADH-G_4Fe-4S_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00926">
        <property type="entry name" value="Molybdop_Fe4S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00929">
        <property type="entry name" value="NADH-G_4Fe-4S_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50692">
        <property type="entry name" value="SSF50692"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54292">
        <property type="entry name" value="SSF54292"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01973">
        <property type="entry name" value="NuoG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51085">
        <property type="entry name" value="2FE2S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51839">
        <property type="entry name" value="4FE4S_HC3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51669">
        <property type="entry name" value="4FE4S_MOW_BIS_MGD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00641">
        <property type="entry name" value="COMPLEX1_75K_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00642">
        <property type="entry name" value="COMPLEX1_75K_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00643">
        <property type="entry name" value="COMPLEX1_75K_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="4 8 9" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="6 8 9" id="KW-0408">Iron</keyword>
    <keyword evidence="7 8 9" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="5 8 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0520">NAD</keyword>
    <keyword evidence="9" id="KW-0874">Quinone</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-1278">Translocase</keyword>
    <feature type="domain" description="2Fe-2S ferredoxin-type" evidence="10">
        <location>
            <begin position="20"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S His(Cys)3-ligated-type" evidence="12">
        <location>
            <begin position="100"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S Mo/W bis-MGD-type" evidence="11">
        <location>
            <begin position="238"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="245"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="248"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="252"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="280"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PJN06767.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="832" mass="87748" checksum="D47C3A9E89A77FF5" modified="2018-04-25" version="1">MTVTTGAPSGGGEAAVPPEDLVSLTIDGIGISVPKGTLVIRAAEQLGIEIPRFCDHPLLDPAGACRQCIVEVEGQRKPMASCTITCTDGMVVKSQLSSPVAEKAQRGVMELLLINHPLDCPVCDKGGECPLQNQAMSHGQSDSRFDGKKRTFEKPVPISPQVLLDRERCVLCARCTRFSNQIAGDPMIELLERGALQQVGTGEGDPFESYFSGNTIQICPVGALTSAAYRFRSRPFDLVSSHSVCEHCAGGCATRTDHRRGKVMRRLASPDPEVNEEWVCDKGRFGFRYAQKPDRLTTPLVRNADGVLEPASWPEALDVAARGLLSARGRAGVLTGGRLTVEDAYAYSKFARVALDTNDIDFRARVHSSEEADFLAARVAGRGRDLDGVGVTYTSLEKAPAVLLVGIEAEEEAPGVFLKLRKAWRGHGQRTFGLAPFATRGLEKAGGTLLPAAPGTETEWLDALASGFGLEDGGAEASQALRAEDAVIVVGERLASVPGALTAVVRAATATGAHLVWIPRRAGERGAIEAGALPSLLPGGRPATDPRAREEVAAVWGVSELPHRYGRDTGQIVEAAAGGELRALVVAGVEVADLPDPARAREALHEVAFVVSLEQRPSEVTDHADVVLPVAAVAEKAGTFLNWEGRARLFEAALKPDQMTRSLAPADARVLQMLADAMDVHLGLPDLRAARGEFDRLGGWSGLRATDSLETASQLPRPASGEAVLAGHRLLLDQGRLQEGDDALAGTRHAARARVSAATAAEAGVKDGDELAVTGPAGTTRLPLQVTEMPDRVVWLPLNSTGGGVASDTGAVPGALVRIGPAGIDEAKEVQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JJ33</accession>
    <name>A0A2M9JJ33_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_37570</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000026">
        <property type="protein sequence ID" value="PJN06787.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN06787">
        <property type="protein sequence ID" value="PJN06787"/>
        <property type="gene ID" value="CG723_37570"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002577">
        <property type="entry name" value="HTH_HxlR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01638">
        <property type="entry name" value="HxlR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51118">
        <property type="entry name" value="HTH_HXLR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH hxlR-type" evidence="1">
        <location>
            <begin position="35"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN06787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="160" mass="17574" checksum="B111465BFB3A3DE3" modified="2018-04-25" version="1">MEEGTSKSPSNCASTASGAGYGDADPFQWDTREDCEVRQILDRVADKWSLLVIALLEHRRLRFTQLRREIDGISQRMLTVTLRQLERDGLVKRTVHPVVPPRVEYELTPLGGTLHETIRSLVAWTEHHQGEIAAARAAYDTRAAQEAAAAAGATIGASAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JJC5</accession>
    <name>A0A2M9JJC5_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SBP_bac_5 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_36390</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000024">
        <property type="protein sequence ID" value="PJN06968.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN06968">
        <property type="protein sequence ID" value="PJN06968"/>
        <property type="gene ID" value="CG723_36390"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042597">
        <property type="term" value="C:periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030678">
        <property type="entry name" value="Peptide/Ni-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039424">
        <property type="entry name" value="SBP_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000914">
        <property type="entry name" value="SBP_5_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30290">
        <property type="entry name" value="PTHR30290"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00496">
        <property type="entry name" value="SBP_bac_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002741">
        <property type="entry name" value="MppA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014935551" description="SBP_bac_5 domain-containing protein" evidence="1">
        <location>
            <begin position="27"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="domain" description="SBP_bac_5" evidence="2">
        <location>
            <begin position="82"/>
            <end position="452"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN06968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="532" mass="57411" checksum="6ED896F025CDDC6E" modified="2018-04-25" version="1">MARTRRIVKAATGTALAVLLAGCSGAGSGDGAGKDDGHSMAIATAAEAPYLNPSNDNGTTGIQIESALWAPLTRVDAKTGKLVNVVADSVTSKDAKTWTIKIKPGWKFTNGEKLTAKSFVDTWNYTAYAPHAFANNGAFQRVEGYEDLNPAKGKPKATTLSGLKVVDDLTFTVTLKAPFSPYPTTLSYLGVAALSAETLKDPDQFKHKPIGYGAYQLDGGWKAGQPVRLTRNKGYAGKDAPQADHITFRFFSNPETAYNEFLAGNVDYVAVPSSKIDSYKTDAPGKWSQAKAAAGINYLNLPVTLKPYTDTRVRRALSLALDRDSLAKLKPGNFPATSFTAPSVDGHRENTCSDCRLDVAQAKKLLREAGGFPGKLRLFFASDNPGEQVYAEALGNMWRQKLGLKIQYVGKPGAEIGPLANAGKLDGIRIMGWGHDYPALEDYLTPMFASYGDVNTGRYRDAKVDRMLGEANAQVDQAQATRDYQAIEDRIAEQMPVLPLSHSRDVYLHAEGVEPLNAPFANVDPVRSTFAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JJE4</accession>
    <name>A0A2M9JJE4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_36525</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000024">
        <property type="protein sequence ID" value="PJN06990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN06990">
        <property type="protein sequence ID" value="PJN06990"/>
        <property type="gene ID" value="CG723_36525"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="146"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="186"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="240"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN06990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="266" mass="28320" checksum="6806E54614885257" modified="2018-04-25" version="1">MDMPSPYAHIKRYYGCRFGRAQLNKLSDMVEDDLPPGSVSFATQFGTSPFRAGSLAALVADVEASPDVAVNRPWDNLTIAVQGPAPDSVCKIEIDSDRTALAVETPTDSTWARGIEARVSEFLTAQAAGRLEQPSPPSAKRLRTSIYGILLWAFALWYSTTVYPGYQEEVVLANGKRALTQASGEAPTSGLIVLSALILWCLSGAVRHFVRMRGDKAALAVTADLPTGNTWHRLSSTDKIATVGAVLAGLAMVGTLVSAGADVLKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JK62</accession>
    <name>A0A2M9JK62_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA polymerase IV</fullName>
            <shortName evidence="3">Pol IV</shortName>
            <ecNumber evidence="3">2.7.7.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">dinB</name>
        <name evidence="5" type="ORF">CG723_35325</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CB01635</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 3">Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1)</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="3">Binds 2 magnesium ions per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the DNA polymerase type-Y family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.7" evidence="3"/>
    <dbReference type="EMBL" id="NNBL01000022">
        <property type="protein sequence ID" value="PJN07261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN07261">
        <property type="protein sequence ID" value="PJN07261"/>
        <property type="gene ID" value="CG723_35325"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006261">
        <property type="term" value="P:DNA-templated DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009432">
        <property type="term" value="P:SOS response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="CDD" id="cd03586">
        <property type="entry name" value="PolY_Pol_IV_kappa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01113">
        <property type="entry name" value="DNApol_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036775">
        <property type="entry name" value="DNA_pol_Y-fam_lit_finger_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017961">
        <property type="entry name" value="DNA_pol_Y-fam_little_finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022880">
        <property type="entry name" value="DNApol_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001126">
        <property type="entry name" value="UmuC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00817">
        <property type="entry name" value="IMS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11799">
        <property type="entry name" value="IMS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100879">
        <property type="entry name" value="SSF100879"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="SSF56672"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50173">
        <property type="entry name" value="UMUC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0227">DNA damage</keyword>
    <keyword evidence="3" id="KW-0234">DNA repair</keyword>
    <keyword evidence="3" id="KW-0235">DNA replication</keyword>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="3" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0515">Mutator protein</keyword>
    <keyword evidence="3" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="UmuC" evidence="4">
        <location>
            <begin position="7"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="106"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="11"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="105"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="site" description="Substrate discrimination" evidence="3">
        <location>
            <position position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00025589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PJN07261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="466" mass="49934" checksum="B3A536CA01315A5D" modified="2018-04-25" version="1">MRTAPTILHLDMDAFYASAEQASKPSLRGKAVVVGGIGPRGVVATASYEARVFGVHSAMPIGQARRLAPNAAYLVPRFQLYREVSEQVMGLLRELSPLVEPLSLDEAFVDLEAGEAAWDAASARLVGERLREDIRAVTGLTGSVGIAASKMLAKIASEEAKPDGLFLIVPGTERAMLGPMSVRTLPGVGPATGDHLRRAGITTVEEIAEAGEDELVRLLGKSHGASLYAMALAHDDRPVVAERDAKSVSVEDTYDVDIHDRVRVRTEVQRLAERCVQRLRGAERSGRTVVLKVRRYDFSTLTRSETLRGPTDDPAVVREAAARLLESVDTTGGVRLLGVGVTGLADYTQEDLFAQARAQAEAEAHAAGGEGETEGVDGAGDEGRVAAEEFVEAADRRWVAGHDVRHEEFGHGWVQGSGLGRVTVRFETPYSEPGRVRTFRTDDPALVPAEPLPLVAAGDVRRVEAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-05-25" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JK97</accession>
    <name>A0A2M9JK97_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Shikimate dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CG723_34105</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000021">
        <property type="protein sequence ID" value="PJN07290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN07290">
        <property type="protein sequence ID" value="PJN07290"/>
        <property type="gene ID" value="CG723_34105"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004764">
        <property type="term" value="F:shikimate 3-dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009073">
        <property type="term" value="P:aromatic amino acid family biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008652">
        <property type="term" value="P:cellular amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046346">
        <property type="entry name" value="Aminiacid_DH-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041121">
        <property type="entry name" value="SDH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013708">
        <property type="entry name" value="Shikimate_DH-bd_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022893">
        <property type="entry name" value="Shikimate_DH_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21089">
        <property type="entry name" value="PTHR21089"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18317">
        <property type="entry name" value="SDH_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08501">
        <property type="entry name" value="Shikimate_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53223">
        <property type="entry name" value="SSF53223"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="2" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Shikimate_dh_N" evidence="3">
        <location>
            <begin position="9"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="domain" description="SDH_C" evidence="4">
        <location>
            <begin position="238"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF18317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PJN07290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="274" mass="28738" checksum="2AC02C9F79168DCB" modified="2018-04-25" version="1">MPAIRRAAVLGSPIAHSLSPVLHRAAYEELGLTDWSYDRFEVDEVALPDFLAGLGPEWAGLSLTMPLKRAVIPLLDTISDTAASVEAVNTVVLTEDGHKVGDNTDIPGMVAALAERGIDKVESAAILGAGATASSALAALSRICAGEIVAYVRSDARAAEMREWGERLDVDVKIGKWSDAMRAFTAPLVVATTPAGTTDALAADIPERPGTLFDVVYDPWPTQLAARWSGYGGAVVSGLDLLVHQAVLQVEQMTGRASAPLGAMRRAGERALAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JKH7</accession>
    <name>A0A2M9JKH7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">IclR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CG723_34585</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000021">
        <property type="protein sequence ID" value="PJN07379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN07379">
        <property type="protein sequence ID" value="PJN07379"/>
        <property type="gene ID" value="CG723_34585"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014757">
        <property type="entry name" value="Tscrpt_reg_IclR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005471">
        <property type="entry name" value="Tscrpt_reg_IclR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09339">
        <property type="entry name" value="HTH_IclR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01614">
        <property type="entry name" value="IclR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00346">
        <property type="entry name" value="HTH_ICLR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51077">
        <property type="entry name" value="HTH_ICLR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51078">
        <property type="entry name" value="ICLR_ED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH iclR-type" evidence="4">
        <location>
            <begin position="26"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="domain" description="IclR-ED" evidence="5">
        <location>
            <begin position="88"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PJN07379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="272" mass="28540" checksum="DD62C6C123ABCD7A" modified="2018-04-25" version="1">MTRKESQAEPGTTAPEKTPKGAAASVQSVDRAVSVLEILARHGEAGVTEIADELDVHKSTAFRLLGVLENRGLVGQAKDRGKYYLGAGVLHLAGAAAVRLDISQEGVPVCRELADELGETVNIAILDDDVAVNIMQARGSASVTAQNWLGRRTPLHATSSGKVLLAHLSSALREGLLARPLARFTPHTATGTASLRAELEAVLDQGYAVAVEELEVGLAAVAAPVFAHDGKVIGAISASGPVYRLTEEHLPELAKRTVAASTELSRRMGYGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-09-29" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JKM0</accession>
    <name>A0A2M9JKM0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Esterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_33490</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000020">
        <property type="protein sequence ID" value="PJN07421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN07421">
        <property type="protein sequence ID" value="PJN07421"/>
        <property type="gene ID" value="CG723_33490"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000801">
        <property type="entry name" value="Esterase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00756">
        <property type="entry name" value="Esterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="39"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN07421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="392" mass="42541" checksum="F5D0E2C72BF1A223" modified="2018-04-25" version="1">MGLTSRALEYATVLAALVCVALTVWVWPRLARRGPAAVLGRLGVIGATQLTILTAVAVAVNTNFDFYGSWDELLGHVDKAPAEVTALGHGGIYTTVGAVRGGLVQPAGPQGLDRVRGIPHGPAAQVGRVESVKIVGRRSRAVNPAFVYLPPQYFQQQFHRQRFPVMVAISGYPGGIMNLAQYLQVPQTADRLLRADRMQPTVIVMVRPTIAPPRDTECVDVPGGPRAETFFTKDLPEALKRAYRVGHDPSAWGALGYSSGGTCALQLTLRHPGVYTSAAALSADYRIGDDLTTGSLFGSGPHAAQRQREHDLIWRLENLPVPRVSVLAASSRSGEKDFSDTMRFLHAVKPPMTSAQIILPRGSHRFTTWQREIAPAMQWMSGQLTFPQDTTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JKQ3</accession>
    <name>A0A2M9JKQ3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_33635</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000020">
        <property type="protein sequence ID" value="PJN07443.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN07443">
        <property type="protein sequence ID" value="PJN07443"/>
        <property type="gene ID" value="CG723_33635"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004104">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02894">
        <property type="entry name" value="GFO_IDH_MocA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GFO_IDH_MocA" evidence="1">
        <location>
            <begin position="8"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="domain" description="GFO_IDH_MocA_C" evidence="2">
        <location>
            <begin position="142"/>
            <end position="377"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN07443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="387" mass="40601" checksum="C156826347E6C10B" modified="2018-04-25" version="1">MTTPHPRSAIVGTGMIGAVHARAVRAAGGVLHGVLGSSAARSTQAAADLDAPHAYPDLDALLADDAVDIVHLCTPNTLHARQALSVLAAGKHLICEKPLATSVADAERVVAAARAAARLVAVPFVYRYHPMVREIRARRQVGEFGNWQLLHGSYLQDWMLPPDTATWRADPAASGPSRAFADIGSHWCDLVEWTAGVEFTEVIARLATTVAQRPMGSSASFGGPERQGAGPLERAAVSTEDAAVLLLRTGDGVLANLTVSQVSAGRKNRLWFELDGGRASAVFDQEEPERVWLGGLDGARILVRDPGQGSAAQRRLAHLPAGHAQGYADCFTAFTRDVHQVVAGEGLPAGLPTAADGLRSARLVEAVLNSAGTDTWTNVGRGALAVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JL15</accession>
    <name>A0A2M9JL15_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MerR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_32885</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000019">
        <property type="protein sequence ID" value="PJN07565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN07565">
        <property type="protein sequence ID" value="PJN07565"/>
        <property type="gene ID" value="CG723_32885"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000551">
        <property type="entry name" value="MerR-type_HTH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13411">
        <property type="entry name" value="MerR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00422">
        <property type="entry name" value="HTH_MERR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="SSF46955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50937">
        <property type="entry name" value="HTH_MERR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH merR-type" evidence="1">
        <location>
            <begin position="8"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN07565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="316" mass="34493" checksum="7BB7E5C35B804103" modified="2018-04-25" version="1">MTEQAVAEYRIEDLAHRSGATVRTIRAYQDRGLLPRPERRGRANVYGDTHLARLRQIADLLDRGYTLASIKELLEAWDAGRGLGGVLGLVAEVDGPWTDEKADRISRADLAARFGGSEDEAAIADAVALGILEQIPGHDDEFLVPSPQELAVAAELHAAGVPLPAISGHLRELRGQIEHIATRFLEFTTEHVFARYLGPLPPTDAEAAEAASLVRRLRPLAQQSVDAELARAMKLFATRHLHRHLSEGPVTSPVEEAHSVALPGDTIRAVQSLVGVERVPEFIAAATEREVQARTLDTLTSNHRDSREVDQMPPIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JLG1</accession>
    <name>A0A2M9JLG1_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Lipoprotein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CG723_32125</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CB01635</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the nlpA lipoprotein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000018">
        <property type="protein sequence ID" value="PJN07720.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN07720">
        <property type="protein sequence ID" value="PJN07720"/>
        <property type="gene ID" value="CG723_32125"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004872">
        <property type="entry name" value="Lipoprotein_NlpA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30429">
        <property type="entry name" value="PTHR30429"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03180">
        <property type="entry name" value="Lipoprotein_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002854">
        <property type="entry name" value="MetQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014598672" description="Lipoprotein" evidence="6">
        <location>
            <begin position="26"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="lipid moiety-binding region" description="S-diacylglycerol cysteine" evidence="5">
        <location>
            <position position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR002854"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR002854-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PJN07720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="276" mass="29590" checksum="D90041E240812B0F" modified="2018-04-25" version="1">MRNTTKITAAVLATGALTLGLTACGSDKGDTKAKASDPLVVAATPVPHAEILEYVKDHLAKKAGLNLEVKEFTDYVTPNTATEDGSVDANYFQTQPYLEDFNKKNATHLESVATVHLEPLGLYSQKAKKLGDLKKGGTIALPNDADNESRALRFLAANKLITLKSGSEATATPQDIAKNPKDLQFKEVEAAQTPRSLQDVDAAVINGNYAIGAHLNPAKDSLALESTKNNAYNNVLAVKKGNEDDPRVEKLAKLLTSPEVKKFIEDKYAGSVLPSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JLH3</accession>
    <name>A0A2M9JLH3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Glycerophosphodiester phosphodiesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CG723_32160</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000018">
        <property type="protein sequence ID" value="PJN07726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN07726">
        <property type="protein sequence ID" value="PJN07726"/>
        <property type="gene ID" value="CG723_32160"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008081">
        <property type="term" value="F:phosphoric diester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030395">
        <property type="entry name" value="GP_PDE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017946">
        <property type="entry name" value="PLC-like_Pdiesterase_TIM-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03009">
        <property type="entry name" value="GDPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51695">
        <property type="entry name" value="SSF51695"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51704">
        <property type="entry name" value="GP_PDE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014598670" evidence="2">
        <location>
            <begin position="41"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="domain" description="GP-PDE" evidence="3">
        <location>
            <begin position="60"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="39"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PJN07726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="393" mass="42766" checksum="61D0D46F360E0A35" modified="2018-04-25" version="1">MGMRKSQESRGSQLGRRSVLGAAVLGAGGAVLGAPGVASADERGSGGHHGGGGYKSLPVPTVIAHRGTSGYRPEHTFGSYQLALDMGAHVIEAGDLVPTKDGHLVCRHEPEIGGTTDVSAHPEFAGRKTTKSLDGVATTGWFTEDFTLAELKTLRAKERIPANRQRNTLYDGRWDIPTFEEVLKWRERQSRERGKEVWIHVETKHPTYFRKLGLGLEERVAPLLRKYGVNRKNSPVFLQSFEPTSIQRLNKLVDNPLVVLLSTANSRPWDFVDAGDPRTVADLITPKGLDEIASYAQGIGPTLDLVIPKDKDGKLLAPTTLVEDAHAAGLILHPYTMRNENTFLPADFKKGTDPNAYGDAFGAFKAYLATGIDGIFSDNCDTALLAREDFLKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JLK2</accession>
    <name>A0A2M9JLK2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">RNA methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_32335</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000018">
        <property type="protein sequence ID" value="PJN07760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN07760">
        <property type="protein sequence ID" value="PJN07760"/>
        <property type="gene ID" value="CG723_32335"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008173">
        <property type="term" value="F:RNA methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1280.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029028">
        <property type="entry name" value="Alpha/beta_knot_MTases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029064">
        <property type="entry name" value="L30e-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001537">
        <property type="entry name" value="SpoU_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013123">
        <property type="entry name" value="SpoU_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029026">
        <property type="entry name" value="tRNA_m1G_MTases_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00588">
        <property type="entry name" value="SpoU_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08032">
        <property type="entry name" value="SpoU_sub_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00967">
        <property type="entry name" value="SpoU_sub_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55315">
        <property type="entry name" value="SSF55315"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75217">
        <property type="entry name" value="SSF75217"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SpoU_sub_bind" evidence="1">
        <location>
            <begin position="34"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN07760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="281" mass="29393" checksum="58CB174260D7EF2E" modified="2018-04-25" version="1">MAAAPELISPKSPRVSAARRLAKRNFRGKERLFLAEGPQAVREAAGHADTLVELFATLDAAERYADIVAEARDAGARLHLADEDVIADISTTVTPQGLVGVCRFLDTPFEDVLAARPKLVAVLANVRDPGNAGTVLRCADAAGADAVVLTDASVDLYNPKSVRASVGSLFHLPVAVGVPVERAVQGLKDAGVRILAADGAGEDDLDTELDRGTMGTRTAWIFGNEAWGLPEETRELADAVVRVPIHGKAESLNLATAAAVCLYASARAQRAPGGCRSVTPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JLN3</accession>
    <name>A0A2M9JLN3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_32390</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000018">
        <property type="protein sequence ID" value="PJN07769.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN07769">
        <property type="protein sequence ID" value="PJN07769"/>
        <property type="gene ID" value="CG723_32390"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014838477" evidence="1">
        <location>
            <begin position="29"/>
            <end position="429"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN07769.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="429" mass="46709" checksum="C0B23D07E07AFE07" modified="2018-04-25" version="1">MRNRDVAAWTSAVVTVLVATALVSPAAAATSAPTPDRACPQLSEKLPWHGQNRARLQRMIDERGTCEGHHGPRPVAAFDWDNTVSKNDVTDATIAWSLKHDKILRPASWKKTSKWLTDDADKALTAACGTAVPVGAPLPTSTDTDCTDEIFNIRESGRTMSGAAAFAGEWNHRRTVPQYAWVPQLFAGHTVPELESYAAQARREALAAPVGSTQTLGTHTIPGYVRYYEQQRDLIRTLQKAGFDVYIVSAGSEPVTEVWSRGRGGVGIDRAHTIAIRSVLDGKGRITTYNEGCGEVGRTQGEAIPYIDGKRCWINQDIFHIKGKSAWEKQRWGKRIALGGGDADTDVTFVGDATGAHLVLNRNKNEVMCRAYDNADGHWVVNPMFIEPLPRKSGSYPCSTAAYNRPEGGFGPVLRPDGSVVPDQADAVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JM13</accession>
    <name>A0A2M9JM13_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HTH hxlR-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_31495</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000017">
        <property type="protein sequence ID" value="PJN07905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN07905">
        <property type="protein sequence ID" value="PJN07905"/>
        <property type="gene ID" value="CG723_31495"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002577">
        <property type="entry name" value="HTH_HxlR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01638">
        <property type="entry name" value="HxlR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51118">
        <property type="entry name" value="HTH_HXLR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH hxlR-type" evidence="2">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="45"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN07905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="67" mass="7826" checksum="FEC96BBE50E163F1" modified="2018-04-25" version="1">MSRKVYATVPPKVEYRATGMAVEWYSSLTDLTKWAERRREAIADSREAYDREHGRPAETTLTTEHRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JM56</accession>
    <name>A0A2M9JM56_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CG723_31805</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000017">
        <property type="protein sequence ID" value="PJN07942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN07942">
        <property type="protein sequence ID" value="PJN07942"/>
        <property type="gene ID" value="CG723_31805"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003137">
        <property type="entry name" value="PA_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000209">
        <property type="entry name" value="Peptidase_S8/S53_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022398">
        <property type="entry name" value="Peptidase_S8_His-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023828">
        <property type="entry name" value="Peptidase_S8_Ser-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015500">
        <property type="entry name" value="Peptidase_S8_subtilisin-rel"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02225">
        <property type="entry name" value="PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00082">
        <property type="entry name" value="Peptidase_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00723">
        <property type="entry name" value="SUBTILISIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="SSF52743"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00137">
        <property type="entry name" value="SUBTILASE_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00138">
        <property type="entry name" value="SUBTILASE_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0720">Serine protease</keyword>
    <feature type="domain" description="Peptidase_S8" evidence="5">
        <location>
            <begin position="297"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="domain" description="PA" evidence="6">
        <location>
            <begin position="895"/>
            <end position="972"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PJN07942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="1338" mass="139267" checksum="C4B0149FD1304974" modified="2018-04-25" version="1">MWRVSATPSLEDAPAGELGSERHAESAGRSVGPPRHQLPRSAHQLNVKGQPMQKARPRRGRTALVSGIAVTVALSLTSQLGTATAATPQAPLDLSSRPTLQKQAATTAAVTLITGDTVSLTTEPDGRQAVSVISGAGTSKTFETVSGQNGDLYVYPDDTTAAVASGTVDRELFNVSRMVRDGYGDAKTDEVPAIVDFQGKPTAAALTQKTEGLPGSDNERVMPRLGLSAVHVDKHSAKGFWQAVKPVHARSRGAQAATVPGTAGVSKLWYDGKAKVALDKSVPQIGAPEAWAKGYDGKGVKVAVLDTGADLNNADVKSEIVQSQSFVNGQTVQDGHGHGTHVASTIAGSGANSDGKYKGVAPGADLLIGKVLANSGQGLDSGILAGMDWAVGQGADVVSMSLGGTDTPGEDVLTNAVNSLSASSGTLFVIAAGNDGRKGESTIGTPGAADAALTVGAVDKSDALADFSSRGPRLGDMAIKPEITAPGVDIVAARAAGTTMGTPVDANYTSANGTSMATPHVAGSAAILKQRHPGWTGQRIKDALTAHAKSAADQTVYQQGYGRVDIPAALDPSLELSGTADFRVIPWQKGTYPTRSRTLTLHNNAATDTVMTVTAGAKDASGTAVPAGTLSLSGAGLSDGRVTVPAGGTAEVTVTLDNNGLKTGQYGGSVTATSDNGESVHAALGFVTSVEQHDVTLKVTDRFGKTPSALRFTLHGLDNTVWQSQTMYANGTATLSVPLGKYSIEGSLYSADPAGGAVSYAADLFTVPNIEVSDRDQTFTVDGTTATDLSVKIKGEKRPLENGQVTTFIVRDPGTAGGYSSFAGIGNLLNLTDIRQGAIPSDGATSGALRLETALARREPLVQLEVTGPGHVTIPLKSSVNAKRFEGTKHTELIDLGAGTEQDFAAADVKGKTVLVSVADVTKADDQATRAAAGGAVAMIVAPADPGPSGSGVPAGQAIPVAHATYDNAATLKGLLAKDKVRIALKGVLESGYSYNPHFTDDRVPADLAKTVDVKEFAKVTNTFHSDGARRLGAENMNIWGPLQVSTGSVGQPLYQGTTRDDYFLAGTGVTYQPSVSANFNDSTWRMNGQRASYLTPGKAYTRSWFDAPMRLSQYEFGPCVFCRADVWQNLPGSNGADNDPTHTLSGLTGTWSFYLNGKPITGFGQLAQEKADYRYVLDQKLTTDVPGVTLGRHMRTEWDFSQAAPTTMAIKDCDTAFIPTPKVCESMPVILLDYDLPLNVLNQARAGLPYTFTVDAGRPKGWTGSTAMAGAKVSVSYDDGATWKEAKVLRKDSNSFQALLRHPKLADTNGYVTLKTEAWDAGGSRTTQTITRAYALK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JM97</accession>
    <name>A0A2M9JM97_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Peptidase M48</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CG723_30220</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CB01635</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="6">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the peptidase M48 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000016">
        <property type="protein sequence ID" value="PJN07978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN07978">
        <property type="protein sequence ID" value="PJN07978"/>
        <property type="gene ID" value="CG723_30220"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001915">
        <property type="entry name" value="Peptidase_M48"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01435">
        <property type="entry name" value="Peptidase_M48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 6" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="1 6" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4 6" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="35"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="80"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M48" evidence="8">
        <location>
            <begin position="118"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PJN07978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="309" mass="32272" checksum="DB0BC36DD246B5D3" modified="2018-04-25" version="1">MHLAVYLPLLLPALAGLSAGPLARRLEPRLATWLLTAAGLILAVSSTVVLGLLAVAGLVRLPLIAALEGYSPTVIARDDPAAWPAALAGAVLLTLAVAATVRLTVRRAGALWSAALEAACLPGRESVVVTDDLHADAYTMPGLPGRIVISHGMLDALDPTGHDIILAHERAHLNHHHYAFVTLAQISAAANPLLRPLATSVAYTVERWADEYAALHTGDRRAVAETVAKAAVATKRTRALRLPSAALGVLGRSPAPGIIPRRVAALLEPPPRRPAHLLAAAGALVGVSSVCVLEAAHDLHEFLELAHLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JMG6</accession>
    <name>A0A2M9JMG6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">LysR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CG723_30765</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CB01635</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LysR transcriptional regulatory family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000016">
        <property type="protein sequence ID" value="PJN08065.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08065">
        <property type="protein sequence ID" value="PJN08065"/>
        <property type="gene ID" value="CG723_30765"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005119">
        <property type="entry name" value="LysR_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000847">
        <property type="entry name" value="Tscrpt_reg_HTH_LysR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00126">
        <property type="entry name" value="HTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03466">
        <property type="entry name" value="LysR_substrate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00039">
        <property type="entry name" value="HTHLYSR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50931">
        <property type="entry name" value="HTH_LYSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH lysR-type" evidence="3">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="295"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PJN08065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="316" mass="34823" checksum="3E50E1164FFE4089" modified="2018-04-25" version="1">MDLNAVRTFVAAADAGQFQEAAAALSITQQAVSKRIAVLEKDLGVRLFTRTPRGAELTIDGQAFLPHARELLRAEDRADASVRPGRRALRVDVINRRIAPAVLLQDFYRTRPDIELDVVTLNADVDTAIAAVEAGTIDATFHAITVAEHHLPASIRTTRVIDDPHELLVGPSHPLADADSVTPAQLAGHRIWMPGMAPGTEWADYYDEFAAAFGLTIDVVGPVFGNEALLDEIADSADLATLVGEGSRYLWPDSYDLRRIPVRNPTPVYPMSLIWRGDNRHPALDAFRAHLEATRAQTPDPEVWEPTWRQRTARRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JMH9</accession>
    <name>A0A2M9JMH9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CG723_30835</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000016">
        <property type="protein sequence ID" value="PJN08079.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08079">
        <property type="protein sequence ID" value="PJN08079"/>
        <property type="gene ID" value="CG723_30835"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046288">
        <property type="entry name" value="DUF6325"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19850">
        <property type="entry name" value="DUF6325"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PJN08079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="155" mass="16526" checksum="F7F25AF331597A70" modified="2018-04-25" version="1">MHFREGGPLVPSGLNADTVGPVDVAVVGFEGNRFNGDVAPALRELQQNGTVRILDLSFVMKAADGSVNVVELTDEEVAEAFQQVTDAQFDLLSDEDLRTVADNLPPESSALVVAWENTWAARLATALRDSQGELLLLERIPRAAVVEAVAALGSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JMR0</accession>
    <name>A0A2M9JMR0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CG723_29510</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000015">
        <property type="protein sequence ID" value="PJN08145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08145">
        <property type="protein sequence ID" value="PJN08145"/>
        <property type="gene ID" value="CG723_29510"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021228">
        <property type="entry name" value="BrxD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10923">
        <property type="entry name" value="DUF2791"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PJN08145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="443" mass="47946" checksum="4340B6F2B008A3D4" modified="2018-04-25" version="1">MSQSALVSVARRREVIDALRRGTVPQAGLDLFAVGLGRFESALDDDLATVTRGGAAFHAIRGDYGSGKTFFARWLTERAKRAGLATAEVQISETETPLHRLETVYRRLTERLATATHQPSALRAVIDSWFYTLEEEVLDGGDLDEEDEAALSEAVTALMERRLADVARTTPAFAAALRGYRGAVAEGDAATAEALIAWLGGQKSVAASARRSAGVRGDLDHFAALGFLQGLLTVLRDCGHPGLLLVLDEIETLQRVRGDVREKGLNALRQLLDEIDAGRFPGLFLVITGTPAFYDGQQGAQRLPPLAQRLATDFTTDPRFDSPRAVQLRLPGFDLPRLGELGRNVRDLYQGAAAHPDRVAARVDDRYVDELATAVTGGLGGKVGIAPRVFLRKLVADVLDRVDEFEDFNPREHYALTIAEAELTGVERNAAAGDADDIALELP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JN08</accession>
    <name>A0A2M9JN08_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_30045</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000015">
        <property type="protein sequence ID" value="PJN08244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08244">
        <property type="protein sequence ID" value="PJN08244"/>
        <property type="gene ID" value="CG723_30045"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd13970">
        <property type="entry name" value="ABC1_ADCK3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004147">
        <property type="entry name" value="ABC1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034646">
        <property type="entry name" value="ADCK3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03109">
        <property type="entry name" value="ABC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC1" evidence="1">
        <location>
            <begin position="93"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN08244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="500" mass="53769" checksum="D140D3DA32FB9216" modified="2018-04-25" version="1">MSDLPRKAVTRTAKLAALPLGFAGRATWGLGKRIGGKSAEIVGRELQQRTADQLFKVLGELKGGAMKFGQAMSVFESALPEEVAGPYRAALTKLQEAAPPMPTRTVHAVLAERLGDEWRENFLEFEDKPAAAASIGQVHRAIWHDGREVAVKVQYPGAGEALLSDLNQLGRFARLLGPLIPGMDIKPLITELRDRVSEELDYGLEAQAQRACAEEFADDPDVHVPDVVHQCDQVLITEWIDGTPLSEVIIDGTDEQRNRAGQLLARFLFSGPSRTSLLHADPHPGNFRLLPDEKNDWRLGVLDFGTVDRLPGGLPETIGTSLRMTLAGNAEAVYELLRTEGFVKETIDLEPDAVLEYLLPIIEPALVDEFTFTRGWMRSQAARIADLRSPAHQLGKQLNLPPSYLLIHRVTLSTIGVLCQLGATVRLRDELERWLPGFLAEDEEPVDDAAGGAVVGPAVGAVEGSAVGAVEGSAVGAVEDISAEAAASAGTSEGVSAAEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JN24</accession>
    <name>A0A2M9JN24_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Histidine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_29715</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000015">
        <property type="protein sequence ID" value="PJN08264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08264">
        <property type="protein sequence ID" value="PJN08264"/>
        <property type="gene ID" value="CG723_29715"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011712">
        <property type="entry name" value="Sig_transdc_His_kin_sub3_dim/P"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07730">
        <property type="entry name" value="HisKA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="41"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="73"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="114"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="141"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="domain" description="HisKA_3" evidence="2">
        <location>
            <begin position="180"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN08264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="380" mass="39880" checksum="AFDABD2D4BB4E446" modified="2018-04-25" version="1">MGQSPRNRREALRKLLWIGIWLVFMADPIDDLVDGGHTAWATALGWLGLVAFVGVYLALVFRHTARAMGRGRLAAILGALAAVAVVMSLTLGAPWLVLFVYVSVSCGAVLPMRYARWSIVAVTAAMVLLGIPLGRGWDLGLVVPALLGGFAMTGVRQLVRTTVELRRARATVAQLAANEERLRLARDLHDLLGHSLSLITLKSELAGRMLPDHPEKAGKEVADIEQVSRQALVDVREAVTGYRRPRLSTELAGARAALAAAGIEADVPADAPDDLPAEQEAALAWTLREAVTNAVRHSGAHRCTVGIALRQTLGGPVMELTVEDDGAGAAAGGSLVPGNGLTGLRERVEGVGGTLDAGPGRDRGFLLVARVPVGSVGSGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JN36</accession>
    <name>A0A2M9JN36_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_29955</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000015">
        <property type="protein sequence ID" value="PJN08227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08227">
        <property type="protein sequence ID" value="PJN08227"/>
        <property type="gene ID" value="CG723_29955"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Epimerase" evidence="2">
        <location>
            <begin position="3"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="250"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN08227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="319" mass="32890" checksum="ABA6E10B4D826704" modified="2018-04-25" version="1">MRVLLLGANGYLGRFVADRLLADPAVQLTALGRGDDADVRFDLATGSPGALTRFLDAVHPGVVINCAGATRGGARDLTRHNTVAVATVCEALRRSGCGARLVQIGCGAEYGPSQPGSSTAEDAVPRPGGPYGVSKLAATELVLGSGLDAVVLRVFSPAGPGTPAGSPLGRLAEAMRRAMQSGDGELKLGGLGAQRDFIDVRDVARAVHAASLSAAQGVINIGSGRAVRLRDAASVLARVAGFGGALHELDSPGGPVRPTLGHPRSDPDHVAPAAHPYPDGCGSWQQADVRTARDRLGWRPRINLEESLADIWMEAACRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JNI5</accession>
    <name>A0A2M9JNI5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CG723_29055</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000014">
        <property type="protein sequence ID" value="PJN08424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08424">
        <property type="protein sequence ID" value="PJN08424"/>
        <property type="gene ID" value="CG723_29055"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008557">
        <property type="entry name" value="PhoX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05787">
        <property type="entry name" value="DUF839"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PJN08424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="696" mass="74881" checksum="FD37E8D800983D64" modified="2018-04-25" version="1">MRKTLPLLGSHNGGRAALTCRFRCGDACFQEVPNTSSNEYVGDVIAGALSRRSMLRTAAVVTVAAATAGTVVGSGAPQAAAATPSGAATGVAHKGEKGARGLRFTPVAPNTADRVTVPEGHAQNVVISWGQPILRGAPAFDPDKQSAKAQAGQFGYNNDFLSLLPLRGEHGRQVLVANHEYTDEILMFKGYDPENPTREQVETAWAAHGLSVVVVEESRRSGRLSAVTRHQLNRRLTATSEFRLSGPVAGSALVRTKADPRGRTVLGTLNNCSGGTTPWGTTLHGEENFNQYFANAGKVTDPATAARLKRYGVTGEASERKWERFDDRFDLAKEPNEANRFGWVVELDPYDPESTPRKRTALGRFKHEAAQPRLTDDGRPVVYMGDDEKFDYFYKFVSSKRVAEGRSRAAHEHNLTLLDEGTLYVARLTGDSPAAEIDGTGKLPADGEFDGGGEWLPLATAGRHGAVSHVDGMTAEEVYLFTRFAGDKVGATKMDRPEDIEPSPHSGKVYVALTNNSDRGKAGKAPTDEANPRNLNKHGQILELTEHRGRADAKTFGWSLFLVAGDPNDPATYFAGFPKDRVSPISCPDNVAFDPHGNLWISTDGNALGTHDGLFGVATRGERRGELKQFLTMPNGAETCGPLVQDRRVLVSVQHPGEVDGASVEKPASAWPDGPGKIVRPSVVSVWREDGCDIGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JNN9</accession>
    <name>A0A2M9JNN9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CG723_28435</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000014">
        <property type="protein sequence ID" value="PJN08486.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08486">
        <property type="protein sequence ID" value="PJN08486"/>
        <property type="gene ID" value="CG723_28435"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045993">
        <property type="entry name" value="DUF5949"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19374">
        <property type="entry name" value="DUF5949"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PJN08486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="166" mass="17439" checksum="C48AAA680C34664C" modified="2018-04-25" version="1">MTSTPTENRAFRAIDLGTLAVIAWSGEHPDEAGDMPFLLAYSLGDGAGGQEASTEAVRTLLENNGLPVGKVVDATSKPSFPVSLLVEAGQAVVNMPYLNAQCVAPPEWLAAAAERGYAYFVFTTRPWTSAVPGSPVAEEDFASFAGDEATLTGAAHCLLPVRKLRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JNR4</accession>
    <name>A0A2M9JNR4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ABC transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CG723_27370</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000013">
        <property type="protein sequence ID" value="PJN08508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08508">
        <property type="protein sequence ID" value="PJN08508"/>
        <property type="gene ID" value="CG723_27370"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="13"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="326"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="241"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="45"/>
            <end position="52"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="377"/>
            <end position="384"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PJN08508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="551" mass="59866" checksum="808C15E4C6766FBB" modified="2018-04-25" version="1">MTTHPNFSGPTSITCAGLTYAWPDGTPVFEDLQVAVGPGRTGLIGLNGSGKSTLLKLIAGELTPASGTVRVTGEVGYLPQNVTLDTSLRVDVALGIAEARAALHAIEAGDASEEHFTAVGDDWDVEERAVAMLSGLGLGHIGLDRTIGEVSGGESVLLRLAALLLGRPDVLLLDEPTNNLDLRARRRLYATVEAWSGVLVLVSHDRELLERVDQIADLRGGEVTWYGGNLSAYEEALAAEQEAAQRMVRVAESDLKKQKRELADAQVKLARRKRYGQKMWDTKREPKVVMGERKRQAQVAAGKHRIMHEEKLAEAKDRLDEAVDAVRDDDEIHVDLPYTAVPPGRTVLTLRELHLAHGARVQGEFELRGPERIALVGRNGAGKTTLLRTITGELEPVEGEAVAHVPLRFLPQRLDVLDEALSVAENVARFAPQATNNRIRSRLARFLFKGARADQQAATLSGGERFRATLAALMLAEPAPQLLMLDEPTNNLDMASVRQLTSALSSYEGALIVASHDVPFLESIGITRWVLLDGELRDTTPEEVRGEAVTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-05-25" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JNT7</accession>
    <name>A0A2M9JNT7_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">YCII domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_27525</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the YciI family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000013">
        <property type="protein sequence ID" value="PJN08532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="SMR" id="A0A2M9JNT7"/>
    <dbReference type="EnsemblBacteria" id="PJN08532">
        <property type="protein sequence ID" value="PJN08532"/>
        <property type="gene ID" value="CG723_27525"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005545">
        <property type="entry name" value="YCII"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03795">
        <property type="entry name" value="YCII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YCII" evidence="2">
        <location>
            <begin position="1"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007689"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN08532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="115" mass="12544" checksum="C3B0D896649D38BF" modified="2018-04-25" version="1">MKFAIVIIENAESRRQIQEDRATYRKAIEGWMGQQAQAGALVGGEAFETESLAPVTVRREADGTRKAVEGPFAGADETLGGYILVEAADRDAAVEIAKSWPNPETLEVRPLWVAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JP04</accession>
    <name>A0A2M9JP04_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">1-phosphofructokinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CG723_27985</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CB01635</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the carbohydrate kinase PfkB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000013">
        <property type="protein sequence ID" value="PJN08601.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08601">
        <property type="protein sequence ID" value="PJN08601"/>
        <property type="gene ID" value="CG723_27985"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016773">
        <property type="term" value="F:phosphotransferase activity, alcohol group as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011611">
        <property type="entry name" value="PfkB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017583">
        <property type="entry name" value="Tagatose/fructose_Pkinase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00294">
        <property type="entry name" value="PfkB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000535">
        <property type="entry name" value="1PFK/6PFK/LacC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="SSF53613"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PfkB" evidence="3">
        <location>
            <begin position="13"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRNR" id="PIRNR000535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PJN08601.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="335" mass="34063" checksum="49530FAFE14A61EC" modified="2018-04-25" version="1">MVSIAITSLNSAIERLLAVETHRPGSVHRLTRSETFAGGKGVNVARVLTQLSAARPEAVEPVPAPLLLGFAGGPTGRLFEDLLATEHLAAALVPTSGATRVCEVLVDLSDPAGATVYNASGPQVEHSELEALEGLFAGTLAKSEALVCTGSVPPGVPADQYARWIAQARDRGILSVLDAHGEVLALGAAALPDVIKVNREELSSLGTGDPADRALGWLDAGIRCVVITDGDRPARAFTAGAEYEVVAPEVPVRSAVGSGDAFCAGLVQSLLGAPRAGWAAHLRTAAACGASNAAATTAGLTSSHSPAALLPRVAVRESALRSAPPPVRRAGGTRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JP32</accession>
    <name>A0A2M9JP32_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Anti-sigma factor antagonist</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CG723_28065</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CB01635</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the anti-sigma-factor antagonist family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000013">
        <property type="protein sequence ID" value="PJN08628.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08628">
        <property type="protein sequence ID" value="PJN08628"/>
        <property type="gene ID" value="CG723_28065"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043856">
        <property type="term" value="F:anti-sigma factor antagonist activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.750.24">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003658">
        <property type="entry name" value="Anti-sigma_ant"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002645">
        <property type="entry name" value="STAS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036513">
        <property type="entry name" value="STAS_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01740">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52091">
        <property type="entry name" value="SSF52091"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00377">
        <property type="entry name" value="ant_ant_sig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50801">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="STAS" evidence="3">
        <location>
            <begin position="5"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PJN08628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="112" mass="12603" checksum="2482E736C9E61823" modified="2018-04-25" version="1">MHPEFHISHRDVTGWTVVEVHGEVDVSSVPQIREHVLTCIEAGRHRLIVDLMGVSFIDSTGLGFLVSIAKRIRTHVGDLRLVMTNPDVLQIFHITGLHRALRIYDSVEAAME</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JP71</accession>
    <name>A0A2M9JP71_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Acyl-CoA dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CG723_26605</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CB01635</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000012">
        <property type="protein sequence ID" value="PJN08671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08671">
        <property type="protein sequence ID" value="PJN08671"/>
        <property type="gene ID" value="CG723_26605"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016627">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="SSF47203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="SSF56645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA_dh_N" evidence="5">
        <location>
            <begin position="6"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_1" evidence="4">
        <location>
            <begin position="260"/>
            <end position="390"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PJN08671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="402" mass="41481" checksum="5EC5668EE182EDE7" modified="2018-04-25" version="1">MDAAFTAEQDEIRGTLHELMNKRCGPEDVKAAVGTPAGYDPALWSALGGELGLPGLALPEQYGGVGCGTTELALACEESGRALAPTPLLATAALAAPLVLALGTEAQRAALLPRIASGALTATLAVPGEGLATALGLTGDNRGDWSGGGRAGGVQARQDDRHDGGWRLYGQADQVLDGHSAGLLIVAAHTGGFARSRTLLFLVDGDAEGVVRTRQTSLDETRPRARVELRHVAAELLGSAEGEGGEVAGALAAMGDAAATVLAAEAVGAAERALERTVEHVRQREQFGRPIGSFQAVKHRLADVYVQVQAARSAAYYAAWAAGSGSGERTGGLALAQALEALRTAASEAVQLHGGIGFTWEHDAHLYIKRATGDELLFGPVHLLRARAAESAELFTRQEATA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JPS2</accession>
    <name>A0A2M9JPS2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">TetR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_25590</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000011">
        <property type="protein sequence ID" value="PJN08871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08871">
        <property type="protein sequence ID" value="PJN08871"/>
        <property type="gene ID" value="CG723_25590"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="11"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="34"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN08871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="212" mass="23460" checksum="2B414AD71E83B7EC" modified="2018-04-25" version="1">MAEGLRERKKRLARQHISDVATGLFLERGFDEVTIAEVAAAADVSVNTVYNYFQVKEDLFLDRAKGSVARLSRFVRARDRGESAAEAVLRELRREVVAVSPEVGLIEGYDRFMKVIEGAAGLRARLWYMQQESLTLLEATLREETGADDGDPLPALMAGQINWIHTTLLSRIAAEMIKARPAGEVSREALGLLDEMEGLLGEPVLNYAARDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-09-29" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JQF8</accession>
    <name>A0A2M9JQF8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Cytosine permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CG723_24625</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CB01635</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the purine-cytosine permease (2.A.39) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000010">
        <property type="protein sequence ID" value="PJN09104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN09104">
        <property type="protein sequence ID" value="PJN09104"/>
        <property type="gene ID" value="CG723_24625"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001248">
        <property type="entry name" value="Pur-cyt_permease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026030">
        <property type="entry name" value="Pur-cyt_permease_Fcy2/21/22"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31806">
        <property type="entry name" value="PTHR31806"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02133">
        <property type="entry name" value="Transp_cyt_pur"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002744">
        <property type="entry name" value="Pur-cyt_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="68"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="108"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="146"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="176"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="209"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="250"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="335"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="360"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="406"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="443"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="474"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="481"/>
            <end position="499"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR002744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PJN09104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="499" mass="52326" checksum="AF293AE9CE7F7038" modified="2018-04-25" version="1">MTDPSPSPSPAASASASPSVEQHTIDHVPENERHGRVRDLFTMWFGTNIAPLPLVTGAMGVQVFHQSFWSSVLAILVGQLVGAVFMALHSAQGPQLGVPQMIQSRAQFGSVGALLIVVVAAAMYLGFFASNIILAGKSLHGLAPAVPVDAGIVLGALGSALICWVGYRLIHTLNKIATWVLGAGVLVGLAVVVGRGLPDGFFSAGSFTFAGWLATVSLSALWQLAFAPYVSDYSRYLPRTVRTASTFWATYWGSCLGSMLPFLAGTVIGLASPGTDDTVAGFDSAAGAFGPVVLLLFLFSVINHNALNLYGAVLSLITICQTFRPSWTPRQRARGVVSAVVLVAALIIATALSSDFVSSFVNLVLVLLVVLVPWTAINLIDFYLVHRGRYALGDLFAPDGGRYGRFNPVALTSYAIGIAVQLPFVATSLYTGPLVAPLGGADLSWLVGLVVTAPVYYVWARRVAVRRGSDVREAGTGTEAGTMTPMPSSARSSDGSGSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JQG3</accession>
    <name>A0A2M9JQG3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GntR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_24490</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000010">
        <property type="protein sequence ID" value="PJN09085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN09085">
        <property type="protein sequence ID" value="PJN09085"/>
        <property type="gene ID" value="CG723_24490"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07377">
        <property type="entry name" value="WHTH_GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
        <property type="entry name" value="GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00035">
        <property type="entry name" value="HTHGNTR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00345">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50949">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH gntR-type" evidence="1">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN09085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="278" mass="30712" checksum="F0E545E981112DCE" modified="2018-04-25" version="1">MADELRARIRAGRLRPGERLPTQARLADEFGVERAAVRQALRVLRSEHLLADVSKGAPATVAQHTGPVFTGPGAPPQPTMVGLGPRVTAAFGARHVQIDALCLTAVSLTLAMGEPLRQIHAGRSNPAKVDVRVLLPSRDIDLAFPTRVGTADARLQRNWLAQRNAQGQVLRHNLLALRSTHGIDVHVTFRALPFTPPIKLYLLNGGEALFAYYTLTRRDEQIDQEYLETYGVQGTRSMLFPFEQGQGQGLRETTFVEQSHLWFDSLWNTISSDLTLTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JQM0</accession>
    <name>A0A2M9JQM0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Threonine synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CG723_24965</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CB01635</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the gamma-elimination of phosphate from L-phosphohomoserine and the beta-addition of water to produce L-threonine.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the threonine synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000010">
        <property type="protein sequence ID" value="PJN09164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN09164">
        <property type="protein sequence ID" value="PJN09164"/>
        <property type="gene ID" value="CG723_24965"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901607">
        <property type="term" value="P:alpha-amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="PLP-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004450">
        <property type="entry name" value="Thr_synthase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="Trypto_synt_PLP_dependent"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="SSF53686"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00260">
        <property type="entry name" value="thrC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014942139" evidence="6">
        <location>
            <begin position="28"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="domain" description="PALP" evidence="7">
        <location>
            <begin position="98"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="5">
        <location>
            <position position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR604450-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PJN09164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="436" mass="45917" checksum="3FDEC471B7BD775E" modified="2018-04-25" version="1">MRRKGLAIMAAQTVATTTSVDLGPASALSCRECGTSFPLGPIFACAECFGPLEVSYDLPTGDPESLRKEIEAGPANIWRYAPLLPVPADVAEKPNLNPGWTKLVKADNLARELGVEQGKLFVKDDSGNPTHSFKDRVVAQAIEAARAFGFTTLSCSSTGNLAGAVGAAAARAGFRSCVFIPHDLEQGKVVMAAVYGGELVGIEGNYDDVNRFCSELIGDPLGEGWGFVNVNLRPYYGEGSKTLAYEICEQLGWRLPDQLVIPIASGSQFTKIDKGLQELIKLGLVEDKPYKLFGAQAEGCSPVSVAYKGGHDVVRPQKPNTIAKSLAIGNPADGPYVLDIARRTGGAVEDVNDEQVVEAIKLLAQTEGIFAETAGGVTVGVTKKLIEAGLIDPALTTVVLNTGDGLKTLDAVAETSQATATIRPSLDAFRDAGLAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JQS8</accession>
    <name>A0A2M9JQS8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_24865</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000010">
        <property type="protein sequence ID" value="PJN09147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN09147">
        <property type="protein sequence ID" value="PJN09147"/>
        <property type="gene ID" value="CG723_24865"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001646">
        <property type="entry name" value="5peptide_repeat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00805">
        <property type="entry name" value="Pentapeptide"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13599">
        <property type="entry name" value="Pentapeptide_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN09147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="233" mass="24675" checksum="ED3743EE5610C4A8" modified="2018-04-25" version="1">MAEKRVVRSAKSSSAKPAAVKKARRPEVRLPPPAPWTGGELEPDGDYDGVEFTAADFTGQDGGGARFMDCALEGCALDETRLTRARILDSTLTGIRGVGTDLAEATLRDVEVVDARLGGVQLHGSVLERVVVRGGKIEYLNLRKARLKDVVFDGCVLVEPDFGGARLDRVEFQGCVVRGADFTGAVMADVDLRGVAELGIARGVDRLAGAVISPAQLFDLAPAFAAQIGVRVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JQZ7</accession>
    <name>A0A2M9JQZ7_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Fused isobutyryl-CoA mutase</fullName>
        </recommendedName>
        <domain>
            <recommendedName>
                <fullName evidence="6">Isobutyryl-CoA mutase</fullName>
                <shortName evidence="6">ICM</shortName>
                <ecNumber evidence="6">5.4.99.13</ecNumber>
            </recommendedName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="6">P-loop GTPase</fullName>
                <ecNumber evidence="6">3.6.5.-</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="6">G-protein chaperone</fullName>
            </alternativeName>
        </domain>
    </protein>
    <gene>
        <name evidence="6" type="primary">icmF</name>
        <name evidence="8" type="ORF">CG723_23350</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CB01635</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the reversible interconversion of isobutyryl-CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>2-methylpropanoyl-CoA = butanoyl-CoA</text>
            <dbReference type="Rhea" id="RHEA:13141"/>
            <dbReference type="ChEBI" id="CHEBI:57338"/>
            <dbReference type="ChEBI" id="CHEBI:57371"/>
            <dbReference type="EC" id="5.4.99.13"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>GTP + H2O = GDP + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>adenosylcob(III)alamin</name>
            <dbReference type="ChEBI" id="CHEBI:18408"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="2">Heterodimer of an alpha and a beta chain.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homodimer.</text>
    </comment>
    <comment type="domain">
        <text evidence="6">Is composed of four functional domains: the N-terminal 5'-deoxyadenosylcobalamin binding region that is homologous to the small subunit of ICM (IcmB), a middle P-loop GTPase domain (MeaI) that likely acts as a chaperone for ICM, a structured linker region involved in dimer formation, and a C-terminal part that is homologous to the large substrate-binding subunit of ICM (IcmA).</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the IcmF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.4.99.13" evidence="6"/>
    <dbReference type="EC" id="3.6.5.-" evidence="6"/>
    <dbReference type="EMBL" id="NNBL01000009">
        <property type="protein sequence ID" value="PJN09291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN09291">
        <property type="protein sequence ID" value="PJN09291"/>
        <property type="gene ID" value="CG723_23350"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031419">
        <property type="term" value="F:cobalamin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047727">
        <property type="term" value="F:isobutyryl-CoA mutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004494">
        <property type="term" value="F:methylmalonyl-CoA mutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034784">
        <property type="term" value="F:pivalyl-CoA mutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006637">
        <property type="term" value="P:acyl-CoA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02050">
        <property type="entry name" value="IcmF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016176">
        <property type="entry name" value="Cbl-dep_enz_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006158">
        <property type="entry name" value="Cobalamin-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036724">
        <property type="entry name" value="Cobalamin-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033669">
        <property type="entry name" value="IcmF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006099">
        <property type="entry name" value="MeMalonylCoA_mutase_a/b_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006098">
        <property type="entry name" value="MMCoA_mutase_a_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02310">
        <property type="entry name" value="B12-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01642">
        <property type="entry name" value="MM_CoA_mutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51703">
        <property type="entry name" value="SSF51703"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52242">
        <property type="entry name" value="SSF52242"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00641">
        <property type="entry name" value="acid_CoA_mut_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51332">
        <property type="entry name" value="B12_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0143">Chaperone</keyword>
    <keyword evidence="3 6" id="KW-0846">Cobalamin</keyword>
    <keyword evidence="5 6" id="KW-0170">Cobalt</keyword>
    <keyword evidence="6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 6" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="B12-binding" evidence="7">
        <location>
            <begin position="16"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Linker" evidence="6">
        <location>
            <begin position="406"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="6">
        <location>
            <position position="29"/>
        </location>
        <ligand>
            <name>adenosylcob(III)alamin</name>
            <dbReference type="ChEBI" id="CHEBI:18408"/>
        </ligand>
        <ligandPart>
            <name>Co</name>
            <dbReference type="ChEBI" id="CHEBI:27638"/>
        </ligandPart>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="208"/>
            <end position="213"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="212"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="237"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="238"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="251"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="254"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="298"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="299"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="345"/>
            <end position="348"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="575"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="610"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="716"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="760"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="809"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="844"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="849"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="961"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="1082"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022628"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PJN09291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="1083" mass="118089" checksum="8422022FF7E6A4AB" modified="2018-04-25" version="1">MSAGDAAARSYRAQHPVRFVTASSLFDGHDASINIMRRILQAQGAEVIHLGHNRSVSEVVDAALEEDVQGVAVSSYQGGHIEYFEYLVESLRERGAGQVRVFGGGGGVIVPQEIERLSRAGVRIFSPEDGQRLGLVGMIRAMIEECDTAPWEEAPAEIGRVLAGERPALARLLSGAAAGTVPAADLRALEKAAGARPVPVLGITGTGGSGKSSLTDELVRRLRTDQGDALRVAVLAVDPTRRRGGGALLGDRIRMNSLDGDRVFFRSLATRGSGELPEGLGESITACKAAGYDLVVVETPGIGQGDAAIVPYADVSLYVMTPEFGAASQLEKIDMLDFADVVAINKFERRGAADAMRDVGRQLVRNREAFGSRPDEMPVFGTSAATFNDDGVTALYQHLRTLLGERGMPVRPGALPAVSVRHSSGAAQIVPPSRARYLAGIAETVRTYHAHTGDQADAARRVQQLTAVRDELIVARASPSDVDRLLGEARERLDKDARGALERWPETVQAYSGDELVVTVRGRELRTGLVRESLSGSRIPRVALPRYTDHGELLRFLREENLPGSFPFTAGVFPFKREGEDPARMFAGEGDPFRTNRRFKLLSEGGEATRLSTAFDSVTLYGRDPDPRPDVYGKVGTSGVSVATLDDMKALYDGFDLVAPTTSVSMTINGPAPTILAFFLNTAIDQRLGAYAAEHDHTPTPEQALEIRADVLRSVRGTVQADILKEDQGQNTCLFSTEFSLRMMGDIQEWFIAQDVRNFYSVSISGYHIAEAGANPISQLAFTLANGFTYVESYLARGMDIDDFAPNLSFFFSNGMDPEYSVLGRVARRIWAVAMRDRYGANERSQKLKYHVQTSGRSLHAQEMDFNDIRTTLQALIAIYDNCNSLHTNAFDEAVTTPTEDSVRRALAIQLIINREWGLAMNENPLQGSYIINELTDLLEEAVLTEFERISERGGVLGAMETGYQRGRIQDESLLYEERKHDGTLPIIGVNTFRNPRAEDGQSAPVVELARATEQEKQSQLARVQDFQARHEDAARNALADLKRAAAGGENVFAVLMDAARVCSLQQITEAFFEVGGAYRRNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JRE9</accession>
    <name>A0A2M9JRE9_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF1990 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_22050</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000008">
        <property type="protein sequence ID" value="PJN09461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN09461">
        <property type="protein sequence ID" value="PJN09461"/>
        <property type="gene ID" value="CG723_22050"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018960">
        <property type="entry name" value="DUF1990"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09348">
        <property type="entry name" value="DUF1990"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF1990" evidence="1">
        <location>
            <begin position="41"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF09348"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN09461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="247" mass="27716" checksum="1B54CA9393BF24AE" modified="2018-04-25" version="1">MLRERRLHRAKAVAALRELADCQVNYEPLPESRSLPTREACWSLDSLRHPLAREPAGDPQQGGAWEIACRLVRDYQFADPAILRAIYSADDTLLGRDMLLEGRFAGLRFDMGVRVTSVIDETRSCSGEESRAWGWSYQTLEGHLEQGELTYEVVKRLRTGAVEFCISGYSRRAPLANPLIHAGFAAFGRTTQQRFYRASARRLQHLTLAELMGAAPLTPRTLPGYDSVVIAPNVWVNTSSRRSCHGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JRJ8</accession>
    <name>A0A2M9JRJ8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_22290</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000008">
        <property type="protein sequence ID" value="PJN09493.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN09493">
        <property type="protein sequence ID" value="PJN09493"/>
        <property type="gene ID" value="CG723_22290"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046134">
        <property type="entry name" value="DUF6131"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19626">
        <property type="entry name" value="DUF6131"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN09493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="51" mass="5201" checksum="2497315ADDE7FD0C" modified="2018-04-25" version="1">MIVLGAILLVIGLLVGISLLTTVGGVLVVVGAVLWILGASGRTVGGRRHYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-06-02" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JRK9</accession>
    <name>A0A2M9JRK9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">MarR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_23585</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000009">
        <property type="protein sequence ID" value="PJN09427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN09427">
        <property type="protein sequence ID" value="PJN09427"/>
        <property type="gene ID" value="CG723_23585"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000835">
        <property type="entry name" value="HTH_MarR-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023187">
        <property type="entry name" value="Tscrpt_reg_MarR-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01047">
        <property type="entry name" value="MarR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00598">
        <property type="entry name" value="HTHMARR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00347">
        <property type="entry name" value="HTH_MARR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01117">
        <property type="entry name" value="HTH_MARR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50995">
        <property type="entry name" value="HTH_MARR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH marR-type" evidence="2">
        <location>
            <begin position="1"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="128"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="131"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN09427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="151" mass="17368" checksum="0A448ED2BB2D8D46" modified="2018-04-25" version="1">MRFTRLVAARRHQTKLEQGAGERVLLARLVRDGEQRATDLAAETFLDLSTVSRQVRSMVERGLIERRPDPEDRRGTLLHATESGRAVYEKNRRQRDAQLAELLDPWPPEDRYQLIRLMTRLNDDLVVHQQQRHGDGTQPEAGAQQGASKHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JRQ8</accession>
    <name>A0A2M9JRQ8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Alpha-xylosidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CG723_22790</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CB01635</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the glycosyl hydrolase 31 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000008">
        <property type="protein sequence ID" value="PJN09566.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN09566">
        <property type="protein sequence ID" value="PJN09566"/>
        <property type="gene ID" value="CG723_22790"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000322">
        <property type="entry name" value="Glyco_hydro_31"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025887">
        <property type="entry name" value="Glyco_hydro_31_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13802">
        <property type="entry name" value="Gal_mutarotas_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01055">
        <property type="entry name" value="Glyco_hydro_31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="SSF74650"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gal_mutarotas_2" evidence="3">
        <location>
            <begin position="161"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU361185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PJN09566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="741" mass="82278" checksum="7021506A2ED489A9" modified="2018-04-25" version="1">MKFTDGFWLMREGVHAAYATEVRQILAADDRFTAYAAVRHVRDRGDTLNQPLITIDCFAPAEGVIGVRFTHHAGKRHRGPDFELLPSEGSAGAQVTREGTVTELKTGPLTVRLDTAGEWGLEFLDSSTGRRLTAVEHKGTAFATTPDGAHHMVAQLALGVGEHIYGLGERFTPFVKNGQTVDIWQADGGTSSEQAYKNVPFHLSSRGYGVLVNHPGKVGYEIGTESVGQLQFSVEDQSIEFYVVAGPTPKDVLRRYTALTGRPALPPAWSFGLWLTTSFCTEYDEETVTSFVDGMAERDIPLTVFHFDCFWMREYQWSDFTWDPDVFPDPVGMLRRLKARGLRISMWINPYIAQKSPLFDEGLASGHLVRKPNGDVWQWDLWQPGMALVDFTNPGARDWYAGKLRDLLDMGVDSFKTDFGERVPTDVVWHDGSDPERMHNYYAHLYNRTVFELLEKERGSGEAVVFARSATAGGQQFPVHWGGDCFASFTAMAESLRGGLSLSLSGFGFWSHDIGGFEGTPDPAVFKRWLAFGLLSSHSRLHGNVSYRVPWAFGEEAVEVARKFTRLKHRLMPYLYGAAVEAHRTGVPVMRPMLLDFPDDPTCRVLDRQYMLGPDLLVAPVFSADGDVEFYLPEGTWTRLLTGERVEGGRWLRETHGFDSLPLFVRPGAVVPLGADDRRPDGDWTDGVTLLVAPGARDVTVTVPDHDGSPAAAYRVRRGAVDGAVTVEVSGAELSYEVREL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JS45</accession>
    <name>A0A2M9JS45_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">IclR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CG723_21025</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000007">
        <property type="protein sequence ID" value="PJN09689.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN09689">
        <property type="protein sequence ID" value="PJN09689"/>
        <property type="gene ID" value="CG723_21025"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014757">
        <property type="entry name" value="Tscrpt_reg_IclR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005471">
        <property type="entry name" value="Tscrpt_reg_IclR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09339">
        <property type="entry name" value="HTH_IclR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01614">
        <property type="entry name" value="IclR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00346">
        <property type="entry name" value="HTH_ICLR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51077">
        <property type="entry name" value="HTH_ICLR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51078">
        <property type="entry name" value="ICLR_ED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH iclR-type" evidence="3">
        <location>
            <begin position="7"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="domain" description="IclR-ED" evidence="4">
        <location>
            <begin position="67"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PJN09689.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="238" mass="24980" checksum="74DAE9972DA265BE" modified="2018-04-25" version="1">MDNSSGVGVLDKAALVLSALESGPATLAGLVAATGLARPTAHRLAVALEHHRMVARDMQGRFILGPRMAELAAAAGEDRLLATAGPVLTHLRDVTGESAQLYRRQGDMRICVAAAERLSGLRDTVPVGSTLTMKAGSSAQILMAWEEPERLHRGLQGARFTATALSGVRRRGWAQSIGEREPGVASVSAPVRGPSNRVVAAVSVSGPIERLTRHPGRMHAQAVIDAAGRLSEALRRTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JSY9</accession>
    <name>A0A2M9JSY9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_19745</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000006">
        <property type="protein sequence ID" value="PJN09963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN09963">
        <property type="protein sequence ID" value="PJN09963"/>
        <property type="gene ID" value="CG723_19745"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="81"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="123"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="150"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="181"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN09963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="211" mass="21381" checksum="577EF791063FE802" modified="2018-04-25" version="1">MSFGDPNNPYGPPQGQPGQQPGYPPQAPQAPQGQPGYGYPQGPPPQQPGYGYPQGQPAYPGFPGGNQMPIEMPGLMKTARVLLFILAGFQLLFGIIAGVAIGAAQDVSNGVGSGDATDTLAGLGFLIAALMVALGALSIFLGVKFKNGGSGIRITTIVYASLMIIGGLVNTINGGGGSATFGGLISLAIAGIILGSMVNSAATTWFNRPRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-05-25" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JT82</accession>
    <name>A0A2M9JT82_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">50S ribosomal protein L1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">rplA</name>
        <name evidence="11" type="ORF">CG723_20460</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CB01635</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release.</text>
    </comment>
    <comment type="function">
        <text evidence="9">Protein L1 is also a translational repressor protein, it controls the translation of the L11 operon by binding to its mRNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Part of the 50S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 9 10">Belongs to the universal ribosomal protein uL1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000006">
        <property type="protein sequence ID" value="PJN10084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN10084">
        <property type="protein sequence ID" value="PJN10084"/>
        <property type="gene ID" value="CG723_20460"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015934">
        <property type="term" value="C:large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00403">
        <property type="entry name" value="Ribosomal_L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01318_B">
        <property type="entry name" value="Ribosomal_L1_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005878">
        <property type="entry name" value="Ribosom_L1_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002143">
        <property type="entry name" value="Ribosomal_L1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023674">
        <property type="entry name" value="Ribosomal_L1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028364">
        <property type="entry name" value="Ribosomal_L1/biogenesis"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016095">
        <property type="entry name" value="Ribosomal_L1_3-a/b-sand"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023673">
        <property type="entry name" value="Ribosomal_L1_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00687">
        <property type="entry name" value="Ribosomal_L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002155">
        <property type="entry name" value="Ribosomal_L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56808">
        <property type="entry name" value="SSF56808"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01169">
        <property type="entry name" value="rplA_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01199">
        <property type="entry name" value="RIBOSOMAL_L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 9" id="KW-0678">Repressor</keyword>
    <keyword evidence="8 9 10" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="7 9 10" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="6 9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4 9" id="KW-0699">rRNA-binding</keyword>
    <keyword evidence="5 9" id="KW-0810">Translation regulation</keyword>
    <keyword evidence="3 9" id="KW-0820">tRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01318"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000659"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PJN10084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="242" mass="25891" checksum="96963205457B4C17" modified="2018-04-25" version="1">MKRSKTLRAADAKIDRDKLYAPLEAVRIAKETSATKFDGTVEVAMRLGVDPRKADQMVRGTVNLPHGTGKTARVLVFATGDRAAAAEAAGADIVGSDELIDEISKGNRLNEFDAVVATPDLMGKVGRLGRVLGPRGLMPNPKTGTVTPDVVKAVNEIKGGKIEFRVDKHSNLHFIIGKVSFDDTQLVENYGAALDEILRLKPSAAKGRYIKKAAIATTMGPGVPLDPNRTRNLLVEEDPAAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JTD6</accession>
    <name>A0A2M9JTD6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CG723_20575</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000006">
        <property type="protein sequence ID" value="PJN10161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN10161">
        <property type="protein sequence ID" value="PJN10161"/>
        <property type="gene ID" value="CG723_20575"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PJN10161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="74" mass="7783" checksum="D7406E4091D595DA" modified="2018-04-25" version="1">MSVPSASRRRNCPECRRDIAVVAGRFARHDPPGARSAGELVSCPGSRRPAQLGAAQPSLDGYVVPTAPGQLPLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-09-29" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JTF5</accession>
    <name>A0A2M9JTF5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CG723_20640</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000006">
        <property type="protein sequence ID" value="PJN10112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN10112">
        <property type="protein sequence ID" value="PJN10112"/>
        <property type="gene ID" value="CG723_20640"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PJN10112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="394" mass="42421" checksum="D8FDB74106292BE2" modified="2018-04-25" version="1">MKTKLQGARVARGWSQAELMDAMADAAARLGFELPSRSSLKTQLSMFENGRRPPGPEYQAIFCEVYEATRLELGFALEAAPSQLDALPKLPSPRGPAPTASPEVLGYLKSVFVQHAQAEPLVGPRFLVPAVQSQVPLIEQLCADAAGPARSEVLRVGLRYAEFLGWLYQDSGDSQEAMLWTNRALDYAYELDDPTLSAYVFQRRANIATEAGHAGYAQGLVNAALNYAGKIPSQVEAVALRARANAHAVLGNASETARALDEARTLAGKDPGDDDGLAPYVSVAYIDMEAANCAIALNRPEDAVRTLEESLVQWPAQQQRDRGLCLARLATAYAQNEDLEGAVSAATQAVSIAQTTGSARILAELTRLQTHLEPFRKLVEIAELNRAVGSMKGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JTJ0</accession>
    <name>A0A2M9JTJ0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcription initiation protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_17530</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the YciI family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000005">
        <property type="protein sequence ID" value="PJN10200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN10200">
        <property type="protein sequence ID" value="PJN10200"/>
        <property type="gene ID" value="CG723_17530"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005545">
        <property type="entry name" value="YCII"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03795">
        <property type="entry name" value="YCII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YCII" evidence="2">
        <location>
            <begin position="1"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007689"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN10200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="111" mass="12251" checksum="9C8D3B98A5F4B290" modified="2018-04-25" version="1">MKYVLLICDDEKVSPSNEELEADPVHRAWLADLDRRGGMLVGARLRPVVDATTVRVRDGETLVSDGPFAETKDFVGGFVIVECADLDEAIAIAEGHPYARWGGVEIRPVWE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JTL6</accession>
    <name>A0A2M9JTL6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Excisionase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_20725</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000006">
        <property type="protein sequence ID" value="PJN10127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN10127">
        <property type="protein sequence ID" value="PJN10127"/>
        <property type="gene ID" value="CG723_20725"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041657">
        <property type="entry name" value="HTH_17"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12728">
        <property type="entry name" value="HTH_17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="SSF46955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH_17" evidence="1">
        <location>
            <begin position="7"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN10127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="62" mass="7166" checksum="03EFAAD480698A3E" modified="2018-04-25" version="1">MASPKKLKLAEVLEEIDMSRAAFYRMRARGQAPRLQRLPNGHLRISRDDLDAWWAACEQRAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JTW8</accession>
    <name>A0A2M9JTW8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Lipase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_18190</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000005">
        <property type="protein sequence ID" value="PJN10313.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN10313">
        <property type="protein sequence ID" value="PJN10313"/>
        <property type="gene ID" value="CG723_18190"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013830">
        <property type="entry name" value="SGNH_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14606">
        <property type="entry name" value="Lipase_GDSL_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SGNH_hydro" evidence="1">
        <location>
            <begin position="176"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN10313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="397" mass="42822" checksum="EE9B880091ED6BDE" modified="2018-04-25" version="1">MHMNDNWTTTPVTADLVRGAYEVERSEHGVLPHRLPARARAQCSDAQLAMAEAQPSGVRLVFRTRATVIELDALRTKMAFKGAPPRPDGVYDLLVDGRLAAQAGVTGGNVQTVDMTTGTRETQPGPIGTVRFTGLPDRMKDVEIWLPYNEITELVALRADAPVERMPDSGRKVWLHHGSSISHGSDAASSSATWPALAAALGGVELMNLGLGGSALLDPFTARALRDAPADLISLKIGINIVNADLMRLRAFAPAVHGFLDTIREGHPTVPLLVVSPIYCAIHEDTPGPSAPDFSNLSAGRLQFMAAGDPAERAAGKLTLNVIRDELARVVKQRIAEDPNLYYLDGRDLYGEADFAELPLPDQLHPDAATHRRMGDRFHTLAFGVDGPFAFAVTERP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JU18</accession>
    <name>A0A2M9JU18_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ricin B-type lectin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_18245</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000005">
        <property type="protein sequence ID" value="PJN10322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN10322">
        <property type="protein sequence ID" value="PJN10322"/>
        <property type="gene ID" value="CG723_18245"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00161">
        <property type="entry name" value="RICIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012878">
        <property type="entry name" value="Glyco_hydro_127"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035992">
        <property type="entry name" value="Ricin_B-like_lectins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000772">
        <property type="entry name" value="Ricin_B_lectin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07944">
        <property type="entry name" value="Glyco_hydro_127"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14200">
        <property type="entry name" value="RicinB_lectin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00458">
        <property type="entry name" value="RICIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="SSF48208"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50370">
        <property type="entry name" value="SSF50370"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50231">
        <property type="entry name" value="RICIN_B_LECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014657306" description="Ricin B-type lectin domain-containing protein" evidence="1">
        <location>
            <begin position="32"/>
            <end position="799"/>
        </location>
    </feature>
    <feature type="domain" description="Ricin B-type lectin" evidence="2">
        <location>
            <begin position="660"/>
            <end position="799"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN10322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="799" mass="87813" checksum="B15E46FBAA321331" modified="2018-04-25" version="1">MPVSRRALLGAGALGLGAAALGGPFAPSAAAASRPSAGTLLPDAFRKLPSGSVTARGWLAGQLKLQLDGLCGRYEDLSHFLDFDNTGWVHPERGAWEELPYWLRGYVPLAVATGDEHALARSREWIDAILATQESDGFFGPRALRTSLNGGPDFWPFLPLLMALRTYEEYSRDRRVVPFVTRFLRFMNAQGAGAFNSSWVSFRWGDGLDIVVWLYRRTGEKFLLDLAGKMHTLGADWTGGTPSRHNVNIAQGFREPAQYAQLTGSAELTRATYRGYDAVMGAYGRFPGGGMAGDENYRPGFGDPRQGFETCGIVEFMASHELLTRITGDPVWADRCEELAFNMLPAALDPQGKSLHYVTSANSIDLDNTPKTQGQFQNGFAMQSLQPGVDQYRCCPHNYGMGWPYFNEELWLATPGDGLAAAMYAPCTVRTRVAGGTEVTIVEETGYPFTETVEFRLSIPKPVRFPLQLRIPGWCRGPELLVNGKRLAAEDGPVWAKVERTWHDGDVVTLRLPQHTSVRHWPDNHDAVSVDHGPLTYSLKIGERYERYAGDDTFPHYEVHATSAWNYGLSPAPGLAFRRDNGPVGENPFTHETTPVHITAQARRIEEWVADDEHVVAPLQSGPARSDASVETVTLVPMGAARLRITAFPQASPDGRTWMPEPAFRRIANKHSGKVLAVDGMSTENSARVVQFANSGTGDHAWQLVDKGDGWHLIRNGQSGKVLGVDGMSTDNSAHVVQYEDNGTADHLWALVDSGDGWYRIRNKNSGKVLGVDGMSTADSAQVVQFDDNGTDDHLWRLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JU85</accession>
    <name>A0A2M9JU85_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Tat pathway signal sequence domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_19040</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000005">
        <property type="protein sequence ID" value="PJN10451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN10451">
        <property type="protein sequence ID" value="PJN10451"/>
        <property type="gene ID" value="CG723_19040"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025326">
        <property type="entry name" value="DUF4232"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14016">
        <property type="entry name" value="DUF4232"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014786651" evidence="1">
        <location>
            <begin position="39"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN10451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="198" mass="20216" checksum="2AC165074AF50F84" modified="2018-04-25" version="1">MRKATVRRETRLMPTRTVLAAAALLVSATGVSATGASAASADPRPAHPAAALKQCAENALTVRAAASGEDHVLRLSVKNHSSHACLVGHVPLVTYGDLDGAAVPFPLSGSATYKLDAGKTAHAAVRSLSASGDADARSVGYVVVAANPEHHGQKFTAASLSEPGGLRVWSPVTTLWQPTRDLADEVLAESVGAGALKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JUQ4</accession>
    <name>A0A2M9JUQ4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_15480</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000004">
        <property type="protein sequence ID" value="PJN10615.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN10615">
        <property type="protein sequence ID" value="PJN10615"/>
        <property type="gene ID" value="CG723_15480"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="23"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="64"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="88"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="119"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN10615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="147" mass="16030" checksum="98006B92122E912C" modified="2018-04-25" version="1">MTAGTAAARLLKPLPRSPWPERWLTRLLLLGLSTAAYVLCMPWDLRNRPETPGSINETTPVTNLGVTILAVTLLALGAYAGRRDRLPLAVLLVAAPPIVLLYASFASHPDPGGIFPWQLVWWFFSLVMAGAVLIAAAVGRTFRKDDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-09-29" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JV18</accession>
    <name>A0A2M9JV18_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 7">Citrate synthase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CG723_16225</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CB01635</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>acetyl-CoA + H2O + oxaloacetate = citrate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16845"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16452"/>
            <dbReference type="ChEBI" id="CHEBI:16947"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="EC" id="2.3.3.16"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 7">Carbohydrate metabolism; tricarboxylic acid cycle; isocitrate from oxaloacetate: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 5 8">Belongs to the citrate synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000004">
        <property type="protein sequence ID" value="PJN10736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN10736">
        <property type="protein sequence ID" value="PJN10736"/>
        <property type="gene ID" value="CG723_16225"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00223">
        <property type="reaction ID" value="UER00717"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004108">
        <property type="term" value="F:citrate (Si)-synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd06114">
        <property type="entry name" value="EcCS_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016142">
        <property type="entry name" value="Citrate_synth-like_lrg_a-sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016143">
        <property type="entry name" value="Citrate_synth-like_sm_a-sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002020">
        <property type="entry name" value="Citrate_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019810">
        <property type="entry name" value="Citrate_synthase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024176">
        <property type="entry name" value="Citrate_synthase_bac-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036969">
        <property type="entry name" value="Citrate_synthase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010953">
        <property type="entry name" value="Citrate_synthase_typ-I"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00285">
        <property type="entry name" value="Citrate_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001369">
        <property type="entry name" value="Citrate_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00143">
        <property type="entry name" value="CITRTSNTHASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48256">
        <property type="entry name" value="SSF48256"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01798">
        <property type="entry name" value="cit_synth_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00480">
        <property type="entry name" value="CITRATE_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5 7" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="active site" evidence="6">
        <location>
            <position position="307"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="364"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004751"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010566"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR001369"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR001369-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PJN10736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="429" mass="47839" checksum="A83D67C52EE3F6FB" modified="2018-04-25" version="1">MSDNSVVLRYGDGEYTYPVIDSTVGDKGFDIGKLRAQTGLVTLDSGYGNTAAYKSAITYLDGEQGILRYRGYPIEQLAERSTFTEVAYLLINGELPTVDELSTFKNEITGHTLLHEDVKRFFDGFPRDAHPMAMLSSVVSALSTFYQDSHNPFDEQQRHLSTIRLLAKLPTIAAYAYKKSIGHPFVYPRNDLGYVENFLRMTFSVPAQEYDLDPVVVAALEKLLILHADHEQNCSTSTVRLVGSSQANMFASISAGISALWGPLHGGANQSVLEMLEGIQANGGDVDSFIRKVKNKEDGVRLMGFGHRVYKSFDPRAKIIKAAAHDVLSALGKSDELLDIALKLEEHALSDEYFVSRNLYPNVDFYTGLIYRAMGFPTEMFTVLFALGRLPGWIAQWHEMIKEPGSRIGRPRQIYTGEVLRDFVPVEAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-09-29" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JVH4</accession>
    <name>A0A2M9JVH4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_17105</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000004">
        <property type="protein sequence ID" value="PJN10883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN10883">
        <property type="protein sequence ID" value="PJN10883"/>
        <property type="gene ID" value="CG723_17105"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="40"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="71"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="94"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="129"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="233"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="263"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="294"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="321"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="348"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="421"/>
            <end position="458"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN10883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="458" mass="44975" checksum="67558BE971743DBF" modified="2018-04-25" version="1">MSRRTPRPLVALFTAGYLAPYLLPTVVGRLGDSLHLPPAQAGLIGSALLMSSAAAGFTFAGRVDRTGPRTLARAGLLLAALGYGAAAATSFVPLVVLGAMAGGFGSGTATTVAATGIAGQRDPHRASTLGLLSVSALAGALYLTMPHLGTGHALPFAAIALTALATWPATSGLESGTAGLPAPAGQHRPASPLPFRRSGLVLAAAMLCWSMAQNSLWGVSSRIGTDQAGLTEITVGAVFAVALGTALVGVLGAGALGSRLGRAAPIGAGTALIACCIVVSARADDLASFATGEIAWNTLYPVVLSYLIGLAASLDPRGRWAVLVGSAASLGTACGPLTGSVLSQTAGYPAMGTTLAVALLVLALPLTAVALHTGGSPLLRPGTVRRRGGAPAALVAGVTGAPAGAVPQMGAAEQPVVEITVSTPQPAPTQEEFSTAGPRGGSAALGQSSNANASTSAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JVM7</accession>
    <name>A0A2M9JVM7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DUF445 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_15465</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000004">
        <property type="protein sequence ID" value="PJN10920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN10920">
        <property type="protein sequence ID" value="PJN10920"/>
        <property type="gene ID" value="CG723_15465"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007383">
        <property type="entry name" value="DUF445"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04286">
        <property type="entry name" value="DUF445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="42"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="70"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN10920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="442" mass="47487" checksum="DABB26A1F5BE47A6" modified="2018-04-25" version="1">MGEHARAGGSSFGTRPAPFGAGPGSFSPADVEKQRGVRRMKTTATGLLLLVAVIYVLAKWGQNSGAGAWAGYVAAAAEAGMVGALADWFAVTALFRRPLGLPIPHTAIIPTKKDQLGVSLGEFVGENFLSSDVVRQRLRAVGIGSRLGTWLAEPEHADRVTAELATALRGALTVLRDSDVQAVVGEAITRRADAQEVAPGIGKMLEKVVADGGHKRVVDLICVRAHDWLVLHEDSVMDAVQGGAPGWTPRFVDRKVGDRVYKELLRFATEMRDMPEHPARGALDRFLGDFASDLQSDTDTRARVERLKSEVIARPEVQDLIASAWSAVRAMIVAAAEDERSQLRLRVRASLLSLGSRMATDARLQDKVDGWVEGAATYVVTTYRKEITSLITDTVAGWDAEHTSKKIEAHIGRDLQFIRINGTVVGSLAGLAIYAVSRALGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JVU7</accession>
    <name>A0A2M9JVU7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_08515</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN11023.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN11023">
        <property type="protein sequence ID" value="PJN11023"/>
        <property type="gene ID" value="CG723_08515"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="55"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN11023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="80" mass="8851" checksum="335FA90470C1543B" modified="2018-04-25" version="1">MTEVLGHGTDPVSALMHLISADNQRWLKDQPLSKQREVAGRYFDSTGVKVAEVMGGLADQPSSQQKADQLIEQERNAKQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JW97</accession>
    <name>A0A2M9JW97_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_09210</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN11129.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN11129">
        <property type="protein sequence ID" value="PJN11129"/>
        <property type="gene ID" value="CG723_09210"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041413">
        <property type="entry name" value="MLTR_LBD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17765">
        <property type="entry name" value="MLTR_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="25"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN11129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="280" mass="30879" checksum="B0066FF0255FAF09" modified="2018-04-25" version="1">MQRENFTDRPGLGHLPDEEVGLAVLLRAWRARAGRKLGLGKPLPQVEVAAAVGMSERWYRDLERGATPRLDARTLTALAGALRLCADERATLFLFAAGGEPFPAVSPADGVDLAPLRRLLDLQPTQPAYLTDNAWNVLAHNEAMAEWFPWVQVPGANLIRWGLTDPEARQQLADWPRHGRAYLAMLRYAMAQYPGHPELAEILLTALADPECRRIWDDGPVIIANRDGHTFRLSIPRFAPHAVDVVTQVLHPVGHPGLRLTFLSLLPGSDVETGADRLDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JX02</accession>
    <name>A0A2M9JX02_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_10960</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN11426.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN11426">
        <property type="protein sequence ID" value="PJN11426"/>
        <property type="gene ID" value="CG723_10960"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008701">
        <property type="entry name" value="NPP1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33657">
        <property type="entry name" value="PTHR33657"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05630">
        <property type="entry name" value="NPP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF029958">
        <property type="entry name" value="Necrosis-inducing_protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014876964" evidence="1">
        <location>
            <begin position="31"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN11426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="255" mass="27594" checksum="B87A72719E032E63" modified="2018-04-25" version="1">MKKSSRISRAALTLGSAVALVIVFPGIALADPPPALPANADGLEQTFQPAYDYDGDGCYPTPAIGPDGTINPGLNPSGAVNGQCHDSWDLDSTNGYSRSKCNNGWCAIMYGLYFEKDQAVAGSGLGGHRNDWEHVVVWVQNNEAKYVSTSAHGNFNVYSSDQIRWDGTHPKAVYHKDGLGTHCFRPATANDEPPENHRHTWQFPTLVGWNGYPSGLREKLSQADFGSAVFGLKDGNFNYHLEKAEPAGIPFDPNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JX58</accession>
    <name>A0A2M9JX58_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">GDP-mannose 6-dehydrogenase</fullName>
            <ecNumber evidence="2">1.1.1.132</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CG723_11240</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CB01635</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Glycan biosynthesis; alginate biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the UDP-glucose/GDP-mannose dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.132" evidence="2"/>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN11470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN11470">
        <property type="protein sequence ID" value="PJN11470"/>
        <property type="gene ID" value="CG723_11240"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00286"/>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047919">
        <property type="term" value="F:GDP-mannose 6-dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042121">
        <property type="term" value="P:alginic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028358">
        <property type="entry name" value="GDPman_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017476">
        <property type="entry name" value="UDP-Glc/GDP-Man"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014027">
        <property type="entry name" value="UDP-Glc/GDP-Man_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036220">
        <property type="entry name" value="UDP-Glc/GDP-Man_DH_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014026">
        <property type="entry name" value="UDP-Glc/GDP-Man_DH_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001732">
        <property type="entry name" value="UDP-Glc/GDP-Man_DH_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00984">
        <property type="entry name" value="UDPG_MGDP_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03720">
        <property type="entry name" value="UDPG_MGDP_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03721">
        <property type="entry name" value="UDPG_MGDP_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF500135">
        <property type="entry name" value="GDPman_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000124">
        <property type="entry name" value="UDPglc_GDPman_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00984">
        <property type="entry name" value="UDPG_MGDP_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="SSF48179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52413">
        <property type="entry name" value="SSF52413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03026">
        <property type="entry name" value="NDP-sugDHase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0016">Alginate biosynthesis</keyword>
    <keyword evidence="6 9" id="KW-0520">NAD</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UDPG_MGDP_dh_C" evidence="10">
        <location>
            <begin position="317"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="8">
        <location>
            <position position="268"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="7"/>
            <end position="12"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="30"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="35"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="86"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="124"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="271"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="331"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR000124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR500135-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR500135-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PJN11470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="438" mass="46728" checksum="74708ED2F9E59732" modified="2018-04-25" version="1">MRVSVFGLGYVGCVSAACLASLGHEVIGVDVNQVKVDLVNDGKAPVVEERIGELTAEAVRTGALRATADVHEAIMGSEVSLVCVGTPSEPNGSLCTTYLERVTEQIGAALAERSGRHTVVLRSTMLPGTCLNLLVPILEKYVDGTAGVDFGVAVNPEFLREGTSVGDFFDPPKTVIGELDPASGDAVAALYEGLPGELFRVPIPTAEAIKYADNAFHGLKIGFANELGAVCQALGVDSHQVMDVFLADRKLNISPAYLRPGFAFGGSCLPKDLRSLVHAAQRADVSVPILAHVLTSNSAHLQRAVELVERTGKRRAGLFGLSFKPGTDDLRESPLVELAERLIGKGYDLRIYDANVNLSRLLGANREYIETRLPHIAQLLVDSVDEVLEHAEVCLVGTKDPAVLSALPHDDGTLLVDLIRIPDADARRAEPGYMGLVW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JXE4</accession>
    <name>A0A2M9JXE4_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Cupin_2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_11730</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN11561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN11561">
        <property type="protein sequence ID" value="PJN11561"/>
        <property type="gene ID" value="CG723_11730"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013096">
        <property type="entry name" value="Cupin_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07883">
        <property type="entry name" value="Cupin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cupin_2" evidence="1">
        <location>
            <begin position="37"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN11561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="157" mass="16616" checksum="F0B6463642D36860" modified="2018-04-25" version="1">MPSARVLLTDVLRAADESRTGALWKLDGAARQLDANVVRLRPGTVVAEHVEPDLDVLLVVLEGDGSLRYADQEEQLAPGALVFIARGERRSVTAGPDGLAYLTAHRRRPGLTIARTPACEGGEPACLLSRICPACDRVSDDATAAYCARCGGRLPAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JYE5</accession>
    <name>A0A2M9JYE5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">LLM class flavin-dependent oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_13920</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN11916.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN11916">
        <property type="protein sequence ID" value="PJN11916"/>
        <property type="gene ID" value="CG723_13920"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011251">
        <property type="entry name" value="Luciferase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036661">
        <property type="entry name" value="Luciferase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00296">
        <property type="entry name" value="Bac_luciferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51679">
        <property type="entry name" value="SSF51679"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bac_luciferase" evidence="1">
        <location>
            <begin position="13"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN11916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="287" mass="31769" checksum="5558FD4CA0930E5F" modified="2018-04-25" version="1">MRFSINIPNFGDFADPRNVATVAAAAEQAGWDGLFVWDHVLHRHHQGRPFGDPWMLLTAAALATSRIRLGTLLTPVPRYRPQQLARQVATLDQLSGGRVIFAAGLGGPIEDEYRSFGDAAEPRVLAERLDEGLELLGRLWSGEPVNHHGRHYEVRDVTMLPATVQRPAPPVWIGGFWPRRAPMRRAARWDGAVPLFETARHGHVPDAAEVRELISYVRSQRTAGTDRPFEFVLGGATPPDAAKAKDVIGPLHDAGATWWDERQIQTGPDLDRLTPVLRRIEAGPPVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JYN1</accession>
    <name>A0A2M9JYN1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ABC transporter substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_14170</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN11958.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN11958">
        <property type="protein sequence ID" value="PJN11958"/>
        <property type="gene ID" value="CG723_14170"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006059">
        <property type="entry name" value="SBP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13416">
        <property type="entry name" value="SBP_bac_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014818978" evidence="1">
        <location>
            <begin position="32"/>
            <end position="411"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN11958.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="411" mass="43209" checksum="33CA8BDC35D437FC" modified="2018-04-25" version="1">MHSRAERRLPPAIAAGLATATAALGLTGCAATPAADTVTVLNSATDTAEHTANQKFFDRCAKPIGLKVEQISVPADQVASKALRMASSKSLSDILELDGSELPQFAGTEGLRPLKDIGVDTSGFSGSATSLGSYDGTQYGIARSVNSLALIYNTKLLKAAGVAPPTTWAELKTAAKKMTHGSTYGMAFSASPNADGVYQFLPFFWSGGGDEAKLDNGKGEAALQLWKDLVSDGSASKSVVNWNQQDVNDQFVAGRAAMMINGPWQVPVLDAQKKVDWAVARIPVPEAGQDAIPPIGGTVMAVPKNEDRSREKNAGKILNCLNSQKNQLKWGESVNNVPTRSAAARAYAEQNPKLAAFADLVTTARSRTAEVGTRWPVVGDALAGAFQSVLTGRTSPEQALHRAQQQASTGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JZ03</accession>
    <name>A0A2M9JZ03_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_08725</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN12099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN12099">
        <property type="protein sequence ID" value="PJN12099"/>
        <property type="gene ID" value="CG723_08725"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="52"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN12099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="71" mass="7864" checksum="AB30E2BCA94CA3B0" modified="2018-04-25" version="1">MSNDSVARFLAALAPEDRETVVARPGEEQERLAAAWERELEGDDELDVLDELSPPAAEAEAARRVLRQESD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K0C5</accession>
    <name>A0A2M9K0C5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_06000</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000002">
        <property type="protein sequence ID" value="PJN12583.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN12583">
        <property type="protein sequence ID" value="PJN12583"/>
        <property type="gene ID" value="CG723_06000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035183">
        <property type="entry name" value="DUF5304"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17230">
        <property type="entry name" value="DUF5304"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="25"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="118"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="139"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN12583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="161" mass="17052" checksum="3EBC57E3E59ADA63" modified="2018-04-25" version="1">MSDATEQPAPEADADAWEKACAEDLAEEKARRRAQHGPPPGSAAEELRKLVDAVAEKLSGLQTPLLGAVAQGTAQQVVSEVVKQAKAAVEPVVERNPEVFDHLAAAGNELLAAYRSAVERQEQRWTQRSSGAQAGRASGDDTDPRDEGPEAPPAGEHIDLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K0L3</accession>
    <name>A0A2M9K0L3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_06520</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000002">
        <property type="protein sequence ID" value="PJN12675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN12675">
        <property type="protein sequence ID" value="PJN12675"/>
        <property type="gene ID" value="CG723_06520"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.4080.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005502">
        <property type="entry name" value="Ribosyl_crysJ1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036705">
        <property type="entry name" value="Ribosyl_crysJ1_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03747">
        <property type="entry name" value="ADP_ribosyl_GH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101478">
        <property type="entry name" value="SSF101478"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN12675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="399" mass="40778" checksum="9E18AFD7D7D23FE3" modified="2018-04-25" version="1">MTPPTVTTRATPRTTGTPTTPHRIEGLLLGIAAGDAAGWPSGRHRAARLPDWTRRLTRELDTFAEQNATTTLPVPIALNQPPEPLRLGPSDDAEWAAFTAASILNATRAGAQSTNVPPDEHVRTALALAWNTLAAEVAEATARADEIESARMPMRARISVRAGLGNLAAGLSPPATGHDNPHYFDDAACVRAAVLAVVHPGEPELAAQLAEFDARYTQDGDGVHGARAMAAAVAAALGGAPVDACVDAALAQLPEGTEIRRNALHAVDLARRAAAARPGLPGNAFALVPVLEHEIVDHVYSYGIAAAETVPVALAVATAAGGDVTEAVPTAACLSRVADSAPALAGALTGAIGGADTLPASWRDACRRLAGCALPRLAGTDLVAIAADLTRATTPKGAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K0M5</accession>
    <name>A0A2M9K0M5_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ribosomal RNA small subunit methyltransferase H</fullName>
            <ecNumber evidence="6">2.1.1.199</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">16S rRNA m(4)C1402 methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">rRNA (cytosine-N(4)-)-methyltransferase RsmH</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">rsmH</name>
        <name evidence="7" type="ORF">CG723_06200</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CB01635</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>cytidine(1402) in 16S rRNA + S-adenosyl-L-methionine = H(+) + N(4)-methylcytidine(1402) in 16S rRNA + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:42928"/>
            <dbReference type="Rhea" id="RHEA-COMP:10286"/>
            <dbReference type="Rhea" id="RHEA-COMP:10287"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74506"/>
            <dbReference type="ChEBI" id="CHEBI:82748"/>
            <dbReference type="EC" id="2.1.1.199"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the methyltransferase superfamily. RsmH family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.199" evidence="6"/>
    <dbReference type="EMBL" id="NNBL01000002">
        <property type="protein sequence ID" value="PJN12620.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN12620">
        <property type="protein sequence ID" value="PJN12620"/>
        <property type="gene ID" value="CG723_06200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071424">
        <property type="term" value="F:rRNA (cytosine-N4-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070475">
        <property type="term" value="P:rRNA base methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01007">
        <property type="entry name" value="16SrRNA_methyltr_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002903">
        <property type="entry name" value="RsmH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023397">
        <property type="entry name" value="SAM-dep_MeTrfase_MraW_recog"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11265">
        <property type="entry name" value="PTHR11265"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01795">
        <property type="entry name" value="Methyltransf_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004486">
        <property type="entry name" value="MraW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81799">
        <property type="entry name" value="SSF81799"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00006">
        <property type="entry name" value="TIGR00006"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 6 7" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="5 6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4 6 7" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="S-adenosyl-L-methionine binding" evidence="6">
        <location>
            <begin position="37"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="56"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="83"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="104"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="111"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010396"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PJN12620.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="319" mass="34647" checksum="8BC323C7E6F41BC2" modified="2018-04-25" version="1">MSQTRHVPVMLQRCLDLLAPALAEPGAVVVDCTLGLGGHSEALLSTFPSCRLVGLDRDKEALRLSGERLAPFGDRATLVHAVYDELPEVLDRLGVPRVQGVLFDLGVSSMQLDEADRGFAYAQDAPLDMRMDQTTGMSAAEVLNTYPPGELVRILRAYGEEKQAKRIVSAVVREREKEPFSNSARLVELIRDALPQAAKRTGGNPAKRTFQALRIEVNGELSVLERAIPAAVQALAVGGRIAVLSYHSLEDRLVKQVFAAGAANTAPPGLPVVPERYQPRLKLLTRGAELPTEEEVAENRRAAPARLRGAQRIREEVAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K0Q2</accession>
    <name>A0A2M9K0Q2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">TetR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CG723_06635</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000002">
        <property type="protein sequence ID" value="PJN12694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN12694">
        <property type="protein sequence ID" value="PJN12694"/>
        <property type="gene ID" value="CG723_06635"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041490">
        <property type="entry name" value="KstR2_TetR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17932">
        <property type="entry name" value="TetR_C_24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="5">
        <location>
            <begin position="13"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="4">
        <location>
            <begin position="36"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PJN12694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="206" mass="23635" checksum="6D344275DCCC04AE" modified="2018-04-25" version="1">MPTKKKPQVTASPERRRELLDTAAEVFAAQGYNATTVRKIADHAGMLAGSLYYHFDSKESMLEEILRTFLDELWHGYDSVLDSRLGPRETLEALVTESFREIDRHRAAVAIYQKESKHLAVQERFEFLAASQRKFEKAWLSTLERGVAAEVFRADLDIRLTYRFVRDTVWVAASWYRPGGQHSPEEIARQYLSMVLDGIAVRATQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K121</accession>
    <name>A0A2M9K121_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cysteine desulfurase</fullName>
            <ecNumber evidence="4">2.8.1.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CG723_07345</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CB01635</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[sulfur carrier]-H + L-cysteine = [sulfur carrier]-SH + L-alanine</text>
            <dbReference type="Rhea" id="RHEA:43892"/>
            <dbReference type="Rhea" id="RHEA-COMP:14737"/>
            <dbReference type="Rhea" id="RHEA-COMP:14739"/>
            <dbReference type="ChEBI" id="CHEBI:29917"/>
            <dbReference type="ChEBI" id="CHEBI:35235"/>
            <dbReference type="ChEBI" id="CHEBI:57972"/>
            <dbReference type="ChEBI" id="CHEBI:64428"/>
            <dbReference type="EC" id="2.8.1.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. Csd subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.8.1.7" evidence="4"/>
    <dbReference type="EMBL" id="NNBL01000002">
        <property type="protein sequence ID" value="PJN12819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN12819">
        <property type="protein sequence ID" value="PJN12819"/>
        <property type="gene ID" value="CG723_07345"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031071">
        <property type="term" value="F:cysteine desulfurase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044249">
        <property type="term" value="P:cellular biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006534">
        <property type="term" value="P:cysteine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06453">
        <property type="entry name" value="SufS_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000192">
        <property type="entry name" value="Aminotrans_V_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010970">
        <property type="entry name" value="Cys_dSase_SufS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00266">
        <property type="entry name" value="Aminotran_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01979">
        <property type="entry name" value="sufS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminotran_5" evidence="5">
        <location>
            <begin position="31"/>
            <end position="406"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PJN12819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="418" mass="45813" checksum="3AE572299D9A02A9" modified="2018-04-25" version="1">MTQLPGLLDTEAIRKDFPILDRVLHDGKKLVYLDNAATSQTPRQVIDTLSEYYEQHNANVHRGVHVLAEEATALYEGARDKVAAFINAPSRDEVIFTKNASESLNLVANMLGWADEPYRVDHETEIVITEMEHHSNIVPWQLLSQRTGAKLRWFGLTDDGRLDLSNIDEIITEKTKIVSFVLVSNILGTLNPVEAIVRRAQEVGALVLIDASQAAPHMVLDVQALQADFVAFTGHKMCGPTGIGVLWGRQELLEDLPPFLGGGEMIETVSMHSSTYAPAPHKFEAGTPPIAQAVGLGAAVDYLTSIGMDKIAQHEHAITEYAVKRLLEVPDLRIIGPTTAEDRGAAISFTLGDIHPHDVGQVLDEEGIAVRVGHHCARPVCLRYGIPATTRASFYLYSTPGEIDALIDGLEHVRNFFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K144</accession>
    <name>A0A2M9K144_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NAD-dependent dehydratase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_07520</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000002">
        <property type="protein sequence ID" value="PJN12852.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN12852">
        <property type="protein sequence ID" value="PJN12852"/>
        <property type="gene ID" value="CG723_07520"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Epimerase" evidence="1">
        <location>
            <begin position="7"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN12852.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="269" mass="29566" checksum="DAD89ECA4E168767" modified="2018-04-25" version="1">MPAPRTVLLTGAAGGLGTLMRGLLPAYGYELRLLDARPIEGEPDAITADLADRDALREAVRGVDAIIHLAGISLESSFDKILKANIEGLYNLYEAAREEGVRRIVFASSNHAIGYTPRPADGDPRVPVDTPRRPDTYYGLSKSFGEDLAQFYWDKFGQETVSVRIGSCFMEPTNVRMMSVWLSPGDGARLFDAAIRAEGVGHTVVYGSSDNTRVWWDLSSARALGYEPQDDSEQYAEKLIAEFGELDPANPDHTRMGGHFVTNPPVWPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K1C7</accession>
    <name>A0A2M9K1C7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Chaplin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CG723_08035</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000002">
        <property type="protein sequence ID" value="PJN12943.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN12943">
        <property type="protein sequence ID" value="PJN12943"/>
        <property type="gene ID" value="CG723_08035"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007155">
        <property type="term" value="P:cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005528">
        <property type="entry name" value="ChpA-H"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03777">
        <property type="entry name" value="ChpA-C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51884">
        <property type="entry name" value="CHAPLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0034">Amyloid</keyword>
    <keyword evidence="2" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014864073" evidence="5">
        <location>
            <begin position="33"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="domain" description="Chaplin" evidence="6">
        <location>
            <begin position="39"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PJN12943.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="80" mass="7788" checksum="9E0559BE39D70332" modified="2018-04-25" version="1">MKKLKRVAAVSMVAGGLVAAGAGMASATDAHADGQAVHSPGVVSGNVIQAPVHVPVNVVGNTVNVIGVLNPAFGNLGVNH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K1I6</accession>
    <name>A0A2M9K1I6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DNA-binding response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CG723_05100</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000002">
        <property type="protein sequence ID" value="PJN12979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN12979">
        <property type="protein sequence ID" value="PJN12979"/>
        <property type="gene ID" value="CG723_05100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00622">
        <property type="entry name" value="HTH_LUXR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="12"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="domain" description="HTH luxR-type" evidence="3">
        <location>
            <begin position="143"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PJN12979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="210" mass="22390" checksum="12C8E1DE55C3E64F" modified="2018-04-25" version="1">MPRDHRPAKSVRVLLAEDQGMMRGALALLLGLEEDIEVVAQVATGDAIVDRALETRPDVALLDIELPGRSGLDAAADLREECPDCRVLILTTFGRPGYLRRAMEAGAAGFLVKDGPVEDLAEAVRRVLRGETVIDPALAAAALSAGPNPLTARECDVLKASVDGATVSDIAGKLHLSESTVRNYLSSAIGKTGTRNRMEALREARQQGWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-09-29" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K218</accession>
    <name>A0A2M9K218_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Two-component system response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CG723_00815</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000001">
        <property type="protein sequence ID" value="PJN13168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN13168">
        <property type="protein sequence ID" value="PJN13168"/>
        <property type="gene ID" value="CG723_00815"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00622">
        <property type="entry name" value="HTH_LUXR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="4"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="domain" description="HTH luxR-type" evidence="3">
        <location>
            <begin position="134"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PJN13168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="201" mass="20718" checksum="8CCCE976C9B3A4D3" modified="2018-04-25" version="1">MSVRVVVAGDHQLVLEAFAETLNGTNGLDVVGLATTYEAVLPAVERHRPTVLLLGEPTMGGKALRAATDVRSRHPKCGVALMVGAATPAVVDRAVAAGALGIVPKNARLPQLITTLMGVAGGCLTVDPALMRPPTAGESALSVREMDVLRLTAGGATVKEIAGELYLAAGTVRNLTSAAIKKLGGRNRFDAARIASEHGWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K249</accession>
    <name>A0A2M9K249_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Arginine deiminase</fullName>
            <shortName evidence="3">ADI</shortName>
            <ecNumber evidence="3">3.5.3.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Arginine dihydrolase</fullName>
            <shortName evidence="3">AD</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">arcA</name>
        <name evidence="5" type="ORF">CG723_00965</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CB01635</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>H2O + L-arginine = L-citrulline + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:19597"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:32682"/>
            <dbReference type="ChEBI" id="CHEBI:57743"/>
            <dbReference type="EC" id="3.5.3.6"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid degradation; L-arginine degradation via ADI pathway; carbamoyl phosphate from L-arginine: step 1/2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the arginine deiminase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.3.6" evidence="3"/>
    <dbReference type="EMBL" id="NNBL01000001">
        <property type="protein sequence ID" value="PJN13195.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN13195">
        <property type="protein sequence ID" value="PJN13195"/>
        <property type="gene ID" value="CG723_00965"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00254">
        <property type="reaction ID" value="UER00364"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016990">
        <property type="term" value="F:arginine deiminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019547">
        <property type="term" value="P:arginine catabolic process to ornithine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018101">
        <property type="term" value="P:protein citrullination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00242">
        <property type="entry name" value="Arg_deiminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003876">
        <property type="entry name" value="Arg_deiminase"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006356">
        <property type="entry name" value="Arg_deiminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01466">
        <property type="entry name" value="ARGDEIMINASE"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0056">Arginine metabolism</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Amidino-cysteine intermediate" evidence="3 4">
        <location>
            <position position="397"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR006356-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PJN13195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="407" mass="45489" checksum="7BC7DE481102E978" modified="2018-04-25" version="1">MGFHVDSEAGRLRRVILHRPDLELKRLTPSNKDALLFDDVLWVRRARQEHDGFADVLRDRGVTVHLFGDLLTETLAIGDARSLVLDRVFDEKEYGPLATDHLRAAFETMPATDLAEALVGGMTKREFLDRHPEPTSVRFHAMDLDDFLLGPLPNHLFTRDTSAWIYDGVSINAMRWPARQRETVHFEAIYRHHPLFRDAGFHLWSQGQADYPSTIEGGDVLVIGQGAVLIGMSERTTPQAVEMLAHKLFAAGSAQTIVALDMPKRRAFMHLDTVMTMVDADTFTQYAGLGMLRSYTIEPGVGERELKVTDHPPEHMHRAIAAALGLSEIRVLTATQDVHAAEREQWDDGCNVLAVEPGVVVAYERNATTNTYLRKQGIEVIEILGSELGRGRGGPRCMSCPVERDPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K2D0</accession>
    <name>A0A2M9K2D0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">IclR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CG723_01560</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000001">
        <property type="protein sequence ID" value="PJN13294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN13294">
        <property type="protein sequence ID" value="PJN13294"/>
        <property type="gene ID" value="CG723_01560"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014757">
        <property type="entry name" value="Tscrpt_reg_IclR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005471">
        <property type="entry name" value="Tscrpt_reg_IclR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09339">
        <property type="entry name" value="HTH_IclR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01614">
        <property type="entry name" value="IclR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00346">
        <property type="entry name" value="HTH_ICLR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51077">
        <property type="entry name" value="HTH_ICLR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51078">
        <property type="entry name" value="ICLR_ED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH iclR-type" evidence="3">
        <location>
            <begin position="15"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="domain" description="IclR-ED" evidence="4">
        <location>
            <begin position="77"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PJN13294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="262" mass="27811" checksum="A19B04AD97C6E33C" modified="2018-04-25" version="1">MTGLSEDSADAARSRSAAERLLAVLGAFDHRRPALSLTEIGRRAALPLATAHRLVGELTAWGALERDAAGSYHVGLRIWELAALAPRGPALREAALPFLEDLYEATHENVHLAVRDGLDVVYIERLSGRHAVGVRSRVGARWPLHATGVGLVLLAHSARTFQDQVCGRPLAAFTPHTLSDPVRLRRALAEVRRTGCAVADRQITDDAVSVAAPVRGPEGDVVAAVSLVVPSAGTQPHSLIPAVRLAGRGISRALGWRPGPGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K2H7</accession>
    <name>A0A2M9K2H7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_01460</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000001">
        <property type="protein sequence ID" value="PJN13280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN13280">
        <property type="protein sequence ID" value="PJN13280"/>
        <property type="gene ID" value="CG723_01460"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="APH" evidence="1">
        <location>
            <begin position="28"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN13280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="308" mass="32812" checksum="5DEB66629127EFBE" modified="2018-04-25" version="1">MSDAPRPTQDTVRRLLDTLLPDGGRLDVSAVAEGGEHSTWWVGTRYVLRLALDAPSSVRQRREIRLRDLVRQHVGIAVPASLASGEWATGRTYTLDTRLQGASGEVVDVTAVGEEDLAGLLGGLREVPAARAEALGLTRTAPRSLDAVRREGARAAELLGGDGEFETARLGQLTPQAAAQLAPQPGAVVVHNDLRGEHLTVTPDGRVRGVLDWTDAVIGDPAEDIAGLSISVGARAAVRAATLAGYGPRASLRGLWLARCDTLVRLGERLHGTDDSPVPLLRTQLERAWEAILLELVTELPDKDPETG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K2I9</accession>
    <name>A0A2M9K2I9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Aminoglycoside phosphotransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_01525</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000001">
        <property type="protein sequence ID" value="PJN13290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN13290">
        <property type="protein sequence ID" value="PJN13290"/>
        <property type="gene ID" value="CG723_01525"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="APH" evidence="1">
        <location>
            <begin position="50"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN13290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="300" mass="32336" checksum="FEE409B074D50036" modified="2018-04-25" version="1">MDEAQARKVLAAAGLLGGQQGGGQRDGGPEGGGMEGELLALGENAVFALGDLVVKVGRDPELLERARRELAVAGWLAGQGVPAVRAAEAEPLLVDGHPVTLWHRVPAALRPAEPRDLAELLRLVHALPAPPFALPRRELLGGVERWLRLAGDAIDPADAAYLRERRDGFADAAAALVPHLTPGPIHGDALPRNVHIGPDGPVLVDLETFSSDLREHDLVVMALSRDRYGLDPEAYDAFTRTYGWDVREWDGCAVLRGARETASCAWVAQHAPTNPKALAEFERRVASLRDGDPTVRWYPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K2S0</accession>
    <name>A0A2M9K2S0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CG723_02255</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000001">
        <property type="protein sequence ID" value="PJN13419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN13419">
        <property type="protein sequence ID" value="PJN13419"/>
        <property type="gene ID" value="CG723_02255"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014760779" evidence="3">
        <location>
            <begin position="30"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="249"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="29"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="196"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="29"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PJN13419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="283" mass="28990" checksum="701DF3CA00FB01D8" modified="2018-04-25" version="1">MRTTRLLVTAGLLGASALTALLGAGTAFAGSSDSGSSGDDKAPTEAGTSFRTAQEVEQGRRATAGASTGDYLYWSFPADAGQRPTVKATVKLPDSAARPSGATWRIDVYDGLRRRQSCMYGTQSRAAAQDAPSVDLSCTLRTVRAWSDQWANDPLPGTYYVRLTAASLTPSDQGLPVSAEVEVASKKVGGSAAVDGSLAAPLVPGSTTEEAAAAADDASDEENGSSASQALATGEPEDGWSSGWWSDRWVWTAAGGILAALAGIGGYALTRGTGRPSRVPPGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K342</accession>
    <name>A0A2M9K342_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">AsnC family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CG723_03005</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000001">
        <property type="protein sequence ID" value="PJN13545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN13545">
        <property type="protein sequence ID" value="PJN13545"/>
        <property type="gene ID" value="CG723_03005"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000485">
        <property type="entry name" value="AsnC-type_HTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019888">
        <property type="entry name" value="Tscrpt_reg_AsnC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019887">
        <property type="entry name" value="Tscrpt_reg_AsnC/Lrp_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01037">
        <property type="entry name" value="AsnC_trans_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13404">
        <property type="entry name" value="HTH_AsnC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00033">
        <property type="entry name" value="HTHASNC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00344">
        <property type="entry name" value="HTH_ASNC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50956">
        <property type="entry name" value="HTH_ASNC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH asnC-type" evidence="4">
        <location>
            <begin position="6"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PJN13545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="324" mass="35056" checksum="DAC42881F7B71314" modified="2018-04-25" version="1">MESPPFDELDLKLLQALEVDGRAPFSRIAAVLGVSDQTVARRYRKLVAEGGLRVVGLQDSLRLGRDHWMLRLRCAPEGAEAIATALARRPDTAWIGLTSGGTEVVCMIVPRTQGDHDDLLLGKLPRTPHIVEIRALQMLHRFFGGPAGWLVKHGPLTADQVAALGPPPQTTGDPVPITPEDAPLTAVLKRDGRAGYPELQRATGRSESAVKRRLDQLIASGSLYIDIEYDSARLGYTNAAVLWITAAPASLDTVGRALAGHREIAYAAATAGPSNLVVTAVTRDTADLYAYISGKLGRLEGVQHVETSPFMRRVKQLTYQPPIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-09-29" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K373</accession>
    <name>A0A2M9K373_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CG723_03170</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CB01635</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000001">
        <property type="protein sequence ID" value="PJN13575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN13575">
        <property type="protein sequence ID" value="PJN13575"/>
        <property type="gene ID" value="CG723_03170"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="39"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="74"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="107"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="131"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="168"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="194"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="265"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="292"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="329"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="354"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="394"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="421"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="1"/>
            <end position="443"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PJN13575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="461" mass="49759" checksum="9ECEA9EA3A4B2F9D" modified="2018-04-25" version="1">MTATDLSTSVPYREVTDANGRVYRVGETDIDILGRKRKWMVILPWVGMMGISSAEYAFASAEDTLHTAHDWNSLHIFWMMTVWVFFQAAVAFPAGRLRESGRLPARWAMMIGASGTFMGYLSLALAPHVVFAYIGFSVLSGMGAGMVYATCVNMVGKWYPERRGGKTGFVNGGFAYGSVPFVFLFTGYMDLTNYRWVLLSVGVLLAAMVAVAGSFFKDPPKNWWPANVDPLHPPEDPRARRSLEKNPPAVKQYTPLEAWRTGRVALMWFCLACTSGVNIFGIAFQVDIGEEAGFAGGIVATAMSLKALVNGSGRGVIGWLSDRYGRKQCLLAVCAILGFAQFGILWSAEAKNLPLFLVFSAISGFGGGAIFPMFAALTADYFGENNNATNYGMVYSSKLVSGLGAGMGAVVVGAWGHSGAFILAGCISFLAGFIALFLSQPGRSKSRDIQPNPQPLGEEMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-05-25" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K3H9</accession>
    <name>A0A2M9K3H9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Squalene synthase HpnD</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">hpnD</name>
        <name evidence="3" type="ORF">CG723_03755</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Carotenoid biosynthesis; phytoene biosynthesis.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000001">
        <property type="protein sequence ID" value="PJN13669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN13669">
        <property type="protein sequence ID" value="PJN13669"/>
        <property type="gene ID" value="CG723_03755"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00799"/>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004311">
        <property type="term" value="F:farnesyltranstransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016767">
        <property type="term" value="F:geranylgeranyl-diphosphate geranylgeranyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016117">
        <property type="term" value="P:carotenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00683">
        <property type="entry name" value="Trans_IPPS_HH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.600.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008949">
        <property type="entry name" value="Isoprenoid_synthase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017828">
        <property type="entry name" value="SQ_synth_HpnD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002060">
        <property type="entry name" value="Squ/phyt_synthse"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019845">
        <property type="entry name" value="Squalene/phytoene_synthase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044843">
        <property type="entry name" value="Trans_IPPS_bact-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033904">
        <property type="entry name" value="Trans_IPPS_HH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00494">
        <property type="entry name" value="SQS_PSY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01212">
        <property type="entry name" value="Phytoene_synthase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48576">
        <property type="entry name" value="SSF48576"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03465">
        <property type="entry name" value="HpnD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01044">
        <property type="entry name" value="SQUALEN_PHYTOEN_SYN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01045">
        <property type="entry name" value="SQUALEN_PHYTOEN_SYN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN13669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="316" mass="34295" checksum="6A412B2F71F5A1BD" modified="2018-04-25" version="1">MSRTVESDQHVSAAVLAAYSYCETVTGQQARNFAYGIRLLPTAKRRAMSAVYAFSRRVDDIGDGGLPPDVKADRLDETRALLARVRDGDVAEDDTDPVGVALAHAAHRFPIPLGGLDELIDGVLMDLRGETYETWDDLKVYCRCVAGAIGRVSLGIFGTEPGARGAERASEYADTLGLALQLTNILRDVREDAADGRTYLPADDLAKFGCSAGFDAPTPPAGSDFAGLVHFEVRRARALFAEGYRLLPLLDRRSGACVAAMAGIYRRLLDRIEREPEAVLRGRVSLPGREKAYVAVRGLSGLDARSVSRQSLRRRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JEJ9</accession>
    <name>A0A2M9JEJ9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">RNAse</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_45510</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000056">
        <property type="protein sequence ID" value="PJN05308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN05308">
        <property type="protein sequence ID" value="PJN05308"/>
        <property type="gene ID" value="CG723_45510"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.380.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007295">
        <property type="entry name" value="DUF402"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035930">
        <property type="entry name" value="FomD-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04167">
        <property type="entry name" value="DUF402"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF159234">
        <property type="entry name" value="SSF159234"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF402" evidence="1">
        <location>
            <begin position="59"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN05308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="170" mass="19274" checksum="48CCCEB9676C3F27" modified="2018-04-25" version="1">MGGGEVRVVVRKFDGSLHWHHTMVRLGQDEYGVWLGESIGTIYGKGEQSEVYATQEPRVMPIPRDAWWTAMFQEAPAQLDVYCDVTTPPKWVHTGEVTTVDLDLDVCRTRADGSVHIADEDEFATHQSRYGYPQHVISHAENTAEWLSAALRDGTEPFATRYRAWLAQVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JEK6</accession>
    <name>A0A2M9JEK6_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Abhydrolase_3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_45430</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000054">
        <property type="protein sequence ID" value="PJN05321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN05321">
        <property type="protein sequence ID" value="PJN05321"/>
        <property type="gene ID" value="CG723_45430"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013094">
        <property type="entry name" value="AB_hydrolase_3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07859">
        <property type="entry name" value="Abhydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Abhydrolase_3" evidence="1">
        <location>
            <begin position="81"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN05321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="313" mass="33704" checksum="DCB6A43B49CC23B1" modified="2018-04-25" version="1">MPLDPLLASLVKQLPAPATEIDDPEQFRTAKRQLFDRLSGQYMERGPAVAEVRLVRLPVKGGEIALRMYRPGGPGPHPIHLYLHGGAWISGSIFENSTDVCCRERAAGAGQVVVAVNYRKAPENRFPTGLEDCYAALLWAAEHAAQIGGRADSISIGGVSAGANLAAALSAKVRGEGGPHIRLQILEVPVTDLVREFESHRQFGEGFALSATTMALAKTAYVASPEQRSHPLASPLRATDFSGLPRTHVMTAEYDMLRDEGAAYAERLDEAGVEVSHTLGQGHVHTSMMLTAALPSARQWRAEVLDVLRSSLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JEU2</accession>
    <name>A0A2M9JEU2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">5,10-methylene tetrahydromethanopterin reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_45355</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000053">
        <property type="protein sequence ID" value="PJN05332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN05332">
        <property type="protein sequence ID" value="PJN05332"/>
        <property type="gene ID" value="CG723_45355"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023934">
        <property type="entry name" value="LLM_FMN-dep_put"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011251">
        <property type="entry name" value="Luciferase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036661">
        <property type="entry name" value="Luciferase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00296">
        <property type="entry name" value="Bac_luciferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51679">
        <property type="entry name" value="SSF51679"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04036">
        <property type="entry name" value="LLM_CE1758_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bac_luciferase" evidence="2">
        <location>
            <begin position="1"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="337"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="352"/>
            <end position="371"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN05332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="371" mass="41460" checksum="AD9F1F76674D434D" modified="2018-04-25" version="1">MQFGIFSVGDVTADPTTGRTPSEHERIKAMLAIALKAEEVGLDVFATGEHHNPPFVPSSPTTMLGYLAARTEKLILSTSTTLITTNDPVKIAEDFAMLQHVAEGRVDVMMGRGNTGPVYPWFGKDIREGINLAFENYALLRRLWDEDVVTWDGKFRTPLQSFTSTPRPLDGVAPFVWHGSIRSPEIAEQAAFYGDGFFHNNIFWPMEHTKQMVNLYRRRFAHHGHGAPEQAIVGLGGQVFMRKNSQDAVREFRPYFDNAPVYGHGPSLEDFTSQTPLTVGSPQQVIERTLGFREHVGDYQRQLFLMDHAGLPLKTVLEQLDILGEEVVPVLRKEFANGRPANVPDAPTHASRVAEAEQKARQENEKEVPSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JEX2</accession>
    <name>A0A2M9JEX2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CG723_45300</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000052">
        <property type="protein sequence ID" value="PJN05353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN05353">
        <property type="protein sequence ID" value="PJN05353"/>
        <property type="gene ID" value="CG723_45300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PJN05353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="284" mass="31111" checksum="7A0A8475A8536E26" modified="2018-04-25" version="1">MSPHTLDRTTRLACEEYLALPTRGGARSASGRLLLDQAHGGQHHLHALLAANLMSPNLSWEPEARRRNAVTQRRTARYVQWIADRGTLLEIKTTIAARVAACILPTVNRHGAINGMPGLRLAGITARRIHLTHLPTGGRIDLIDDVMTHASEHQQVFKKEVVVGNRRERPVFEQDTLDPAELTHPQLTEPAHCPQLLAGLLVRAVALWWHLGIDAAWLPPSPQHSTPCLTWLARSGADVDEVGDLLTRSPIAVPDLAYASAGRHGGLLTLGSERVRLQLAELPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-06-02" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JEY2</accession>
    <name>A0A2M9JEY2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CG723_45175</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000051">
        <property type="protein sequence ID" value="PJN05363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN05363">
        <property type="protein sequence ID" value="PJN05363"/>
        <property type="gene ID" value="CG723_45175"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032196">
        <property type="term" value="P:transposition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017894">
        <property type="entry name" value="HTH_IS21_transposase_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002560">
        <property type="entry name" value="Transposase_DDE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029261">
        <property type="entry name" value="Transposase_Znf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01610">
        <property type="entry name" value="DDE_Tnp_ISL3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14690">
        <property type="entry name" value="zf-ISL3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50531">
        <property type="entry name" value="HTH_IS21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0814">Transposable element</keyword>
    <keyword evidence="2" id="KW-0815">Transposition</keyword>
    <feature type="domain" description="HTH IS21-type" evidence="6">
        <location>
            <begin position="285"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="450"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="451"/>
            <end position="487"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PJN05363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="524" mass="57980" checksum="A1C8A245ECB721AE" modified="2018-04-25" version="1">MGDHASGLLKVLFPHLTQVLIDSVARIGKSIRIAARCTAPTARCSGCGTVSSRVHSRYGRRLADTAVSWQETAIDLEVRRFFCDNTACVKKTFAEQVDQLTFRYGRRTLTLQRALQQVALALGGQAGERLAGHLAVPVSGPTLLRLIRGMDLPEVPELTVLGVDEFAFRRGRRFGAILIDMDSRRPVDVLPDHTADTFADWLREHPHIGTVCRDRGGAFAEGAERGQPGIPQVADRWHLLHNLATGLEKTVTRHRSCLKVREIEPAPVQAREPDEESAYERKIRERHRDVQAQFQQGLTIAAISARLGLDRKTVRRYARAATAESLMRERPSRTSALTPHKPYLARRWAEGCDNAQTLRGEIAARGYRGGRKSVRRFLNTLSRHNGPRAVPPPPPAVADVVRWIIGRSENQSDQARQDLKDVCGRCPEIAEACRLARGFATILRRLDGTGSVSGSLRQTSPRSRRSAPSATDFARTSQPSSAGLTLPLSSGAVEGNVTRIKLLKRQHYGRAGFDLLKRRILLAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JFM7</accession>
    <name>A0A2M9JFM7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Alpha/beta hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_43610</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000044">
        <property type="protein sequence ID" value="PJN05632.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN05632">
        <property type="protein sequence ID" value="PJN05632"/>
        <property type="gene ID" value="CG723_43610"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000639">
        <property type="entry name" value="Epox_hydrolase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00412">
        <property type="entry name" value="EPOXHYDRLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014883502" evidence="1">
        <location>
            <begin position="27"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="domain" description="AB hydrolase-1" evidence="2">
        <location>
            <begin position="75"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN05632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="356" mass="39134" checksum="7B7AF6E0947236B0" modified="2018-04-25" version="1">MISRRTFGKVVSTGAVASSTVGLSVACSTAISGENDHFPQTNEQVKENSGFGSLKQVEAGVLNVGYAELGPAHGPVVVLLHGWPYDIHSYVAVAPLLAEKGYRVIVPYLRGHGTTRFISSGTFRNAQQSVFALDIIALMDALRIDKAVLAGYDWGSRTADIIAALWPERVKGLVSVTGYLITNLEANKKPLPPKLEWAWWYQFYFATERGRLGLEQNRHDLAKQIWKFNSPTWGFDDATFDRTAAAFRNPDYVSIVIDNYRWRLSLAKGDPRYDDLEKRLAASPVITVPAISLDGEADPFTPVGGGSSYRDKFTGHYAHRTLKGIGHNLPQEAPREFAQAVVDVDHFPAAGRTSSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-09-29" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JFP3</accession>
    <name>A0A2M9JFP3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">(2Fe-2S)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CG723_43040</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000042">
        <property type="protein sequence ID" value="PJN05709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN05709">
        <property type="protein sequence ID" value="PJN05709"/>
        <property type="gene ID" value="CG723_43040"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00207">
        <property type="entry name" value="fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002888">
        <property type="entry name" value="2Fe-2S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036884">
        <property type="entry name" value="2Fe-2S-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036010">
        <property type="entry name" value="2Fe-2S_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001041">
        <property type="entry name" value="2Fe-2S_ferredoxin-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006058">
        <property type="entry name" value="2Fe2S_fd_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00111">
        <property type="entry name" value="Fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01799">
        <property type="entry name" value="Fer2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47741">
        <property type="entry name" value="SSF47741"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54292">
        <property type="entry name" value="SSF54292"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00197">
        <property type="entry name" value="2FE2S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51085">
        <property type="entry name" value="2FE2S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="2Fe-2S ferredoxin-type" evidence="3">
        <location>
            <begin position="28"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PJN05709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="190" mass="19923" checksum="23FA559354A549A5" modified="2018-04-25" version="1">MTTDLATPDPAPATHAAPPPLAEPSGWHEIRLTVNGAPVTGQVESRLLLSDFLRDRLRLTGTHVGCEHGVCGACTVLVDGEPARSCLTLAVQCAGAELRTVEGLAPGDAPLTPVQRAFHECHGMQCGFCTPGFVMTATALTEQPERPDAADVADALSGHLCRCTGYRNIRRAVCQALDERFAGGPAGRGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JFT4</accession>
    <name>A0A2M9JFT4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CG723_43220</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000042">
        <property type="protein sequence ID" value="PJN05741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN05741">
        <property type="protein sequence ID" value="PJN05741"/>
        <property type="gene ID" value="CG723_43220"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015833">
        <property type="term" value="P:peptide transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013563">
        <property type="entry name" value="Oligopep_ABC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08352">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01727">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="5"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="45"/>
            <end position="52"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PJN05741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="328" mass="35385" checksum="3490F651B2A2A9AB" modified="2018-04-25" version="1">MSPLLETIGLTRHFKVGTGLTRRVLHAVDDVDLTIGAREIVALVGESGSGKSTLARLVAQVHRPTSGEIRYEGQPLTAQRGRKAKLAYRGDVPMVFQDPFASLNPAYRVSHGILRGLKLHRPELSGAERQAETERVVEAVGLTPAADVLARFPYELSGGQRQRIGFAQALAHRPKLILADEPVSMLDVSIRIGLLNVMADLRETEGVSILYITHDIAGARYLSDRIAVMYGGHVVETGPTEDVLAHPRHPYTELLLSAVPDPRAPLDVDAAAAKTDPPVVIDPTPSCRFRTRCPLAVDECHHVTPRLQPVGGGHTAACHVTAPPEGAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JFW0</accession>
    <name>A0A2M9JFW0_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 7 9">GTPase Der</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">GTP-binding protein EngA</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">der</name>
        <name evidence="11" type="ORF">CG723_42815</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CB01635</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7 9">GTPase that plays an essential role in the late steps of ribosome biogenesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Associates with the 50S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7 8 9">Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngA (Der) GTPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000041">
        <property type="protein sequence ID" value="PJN05769.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN05769">
        <property type="protein sequence ID" value="PJN05769"/>
        <property type="gene ID" value="CG723_42815"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00195">
        <property type="entry name" value="GTPase_Der"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031166">
        <property type="entry name" value="G_ENGA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016484">
        <property type="entry name" value="GTP-bd_EngA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032859">
        <property type="entry name" value="KH_dom-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015946">
        <property type="entry name" value="KH_dom-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14714">
        <property type="entry name" value="KH_dom-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006485">
        <property type="entry name" value="GTP-binding_EngA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00326">
        <property type="entry name" value="GTP1OBG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03594">
        <property type="entry name" value="GTPase_EngA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51712">
        <property type="entry name" value="G_ENGA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7 9" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5 7 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 7" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="domain" description="EngA-type G" evidence="10">
        <location>
            <begin position="53"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="domain" description="EngA-type G" evidence="10">
        <location>
            <begin position="228"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="59"/>
            <end position="66"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="106"/>
            <end position="110"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="168"/>
            <end position="171"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="234"/>
            <end position="241"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="281"/>
            <end position="285"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="346"/>
            <end position="349"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00020953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PJN05769.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="490" mass="53189" checksum="A7CB18AD312D1BF7" modified="2018-04-25" version="1">MNDQIQPEGSAEHEHGALGDAEYAEFMELAAVEGFDIEDVEGAIEEAGHGPLPALAVVGRPNVGKSTLVNRIIGRREAVVEDKPGVTRDRVSYEAEWAGRRFRLVDTGGWEQDVLGIDASVAAQAEYAIETADAVVFVVDATVGPTDTDLAVVRLLRKAGKPVVLCANKVDGPSGEADATALWSLGLGEPYPVSALHGRGTGDMLDAVIEALPDAPAQTFGTAIGGPRRIALIGRPNVGKSSLLNKVANEDRVVVNELAGTTRDPVDELIELGGKTWKFVDTAGIRKRVHLQQGADYYASLRTAAAVEKAEVAVILIDASESISIQDQRIVTMAVEAGRAIVVAYNKWDTLDEERRYYLEREIETELAQVAWAPRVNVSATTGRHMEKLVPAIETALDGWETRVPTGRLNAFLGELVASHPHPIRGGKQPRILFGTQAGTKPPRFVLFASGFIEAGYRRYVERRLREEFGFEGTPIHISVRVREKRGRKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JG05</accession>
    <name>A0A2M9JG05_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DNA-binding response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CG723_42465</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000040">
        <property type="protein sequence ID" value="PJN05808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN05808">
        <property type="protein sequence ID" value="PJN05808"/>
        <property type="gene ID" value="CG723_42465"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="4"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="domain" description="HTH luxR-type" evidence="3">
        <location>
            <begin position="135"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PJN05808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="202" mass="21155" checksum="C805021117A090D6" modified="2018-04-25" version="1">MTVRVLLADDEHLIRGALAALLGLEDDLVVVAEAATGPEALAMARAHRPDVAVLDLEMPGADGVKVATALRGELPACRVMIVTGHGRPGHLKRALSAGVRAFVPKTVSAQRLAEIIRTVHAGNRYVDPELAADAIAAGDSPLTAREAEVLEFAADGAPVAEIAERAALSQGTVRNYLSSAVSKLGAENRHSAVRLARERGWV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JG79</accession>
    <name>A0A2M9JG79_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_42375</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000039">
        <property type="protein sequence ID" value="PJN05884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN05884">
        <property type="protein sequence ID" value="PJN05884"/>
        <property type="gene ID" value="CG723_42375"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="61"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="148"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="176"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="247"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="270"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="322"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="351"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="375"/>
            <end position="399"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN05884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="599" mass="63224" checksum="787E1FD0C109B358" modified="2018-04-25" version="1">MRGLCGAACRGDRRTHRAHAGVTVNAMLLALLDNRRPDRARTVPAARASPASRTRRWADPAAVLAATALIAVRAAGLGRWIVDDAAVTFAYARSVDEGLGPVQLPGAALVEGYSNPSWLALMALGRRLGLFDHGAFLGVSDLVLYPKALALLCTAGTLACIAWTARAVLPGRAWAVTLLAGTALATNLSYVAWSFSGLENPLYGLSAAATAALLVRGVTRGDLTAPRTAVAVAAIALLAALTRPDGAVLAGAYPLVLALFVRRRELPRSVRALALHAGVVAVPYGAFLLWRHAVFGLWVPNTAVAKAQQTPRLAQLAQTGDLLTYAGWAIALIGALCAGAVLTRPGKGRRALVALLVPLLLSLLAYGVLGRDWMALYRFATPVWVLAAAVAALSAVVLWEAEGTRGRAVFVAALTGALVLSHAGQADREASFKAHPTLSMCFVAERYGQVFNTYAERLGLRHATVALPDLGGTLLTTRLRVLDLAGLTDRRIANAYASGDMSALRDHVLRAERPELLHVHEAWVDKPGLTLARLADAGYVPLYRQQNGGDFVRADAVPDPARITAVRAWAKPRLDRLIASQDHTRGCGATLTPGQGVAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-06-02" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JGC2</accession>
    <name>A0A2M9JGC2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_42185</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000038">
        <property type="protein sequence ID" value="PJN05940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN05940">
        <property type="protein sequence ID" value="PJN05940"/>
        <property type="gene ID" value="CG723_42185"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="90"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="103"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="139"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN05940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="193" mass="20098" checksum="0431E136887DA231" modified="2018-04-25" version="1" fragment="single">TAATREWALDHLDLPLTLAELADHAQMSLRTFARRFRDEAGSRARLLPATIRAVPSASWSRVSPLSRTARSATHAAVRAGSAARPATLRSRAAVAGSSARCRPAQSARANPSSAATGRLSPSSSAAGRVTALRPASSAAVKPSRSSASGVSTEAAVTATAPDMSLTRARSRARGTPRPGTADRWPWSAPRWAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JGP1</accession>
    <name>A0A2M9JGP1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CG723_41185</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000036">
        <property type="protein sequence ID" value="PJN06023.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN06023">
        <property type="protein sequence ID" value="PJN06023"/>
        <property type="gene ID" value="CG723_41185"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HATPase_c" evidence="3">
        <location>
            <begin position="307"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="445"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="501"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="64"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="511"/>
            <end position="536"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PJN06023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="536" mass="56087" checksum="5163224884FFD6E6" modified="2018-04-25" version="1">MEHATPPPAARAPVAWNNSWWLMPLALGAGTVATAVAGPDPVQIPATFAGIAATAASGACVRLLVRSQAKLSRATADVATAQAEHHQQAENQRQQWERYVAGLKQEFAVERSALEAQLAEEAHAHEARLGVEAERQQAVFARLSDAHLPSALERLRAGDAIDDVLAEVDEPAATPELRAEVRKVLRTALIAVEEQLDRATSAEHSVVSIASRLQALISGVRGRLHDLQTEHGQRPAVAQGLMDLDQRLGPADGLAASVAVLGGSVRPGRQWQEPQKLLSVVRGGQGRIKDFDRVKVDALPELGVDGGLVDHLTLIFAHVLDNAARYSPPSEPVQVSGRQVPAGVGIQIQDAGKGLSEEKKREAEQALAGTAAGPGLGGISENANLGLRVVGILARRYGIRVTFTDSPWGGTSVVVLVPHKYFSPLPAAAPKPVAAAVVAEPSAEPAPVLASAATDTDTTPGGLPRRKGLRSAKAELLGHAVHTDEAVSDVPSEASFDGLAAFATAGRQSGPPRERHADRDAAGSGESAGRDTEESD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JGP5</accession>
    <name>A0A2M9JGP5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Serine protease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CG723_41305</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CB01635</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the peptidase S8 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000036">
        <property type="protein sequence ID" value="PJN06044.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN06044">
        <property type="protein sequence ID" value="PJN06044"/>
        <property type="gene ID" value="CG723_41305"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000209">
        <property type="entry name" value="Peptidase_S8/S53_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023827">
        <property type="entry name" value="Peptidase_S8_Asp-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022398">
        <property type="entry name" value="Peptidase_S8_His-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023828">
        <property type="entry name" value="Peptidase_S8_Ser-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015500">
        <property type="entry name" value="Peptidase_S8_subtilisin-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010259">
        <property type="entry name" value="S8pro/Inhibitor_I9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037045">
        <property type="entry name" value="S8pro/Inhibitor_I9_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05922">
        <property type="entry name" value="Inhibitor_I9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00082">
        <property type="entry name" value="Peptidase_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00723">
        <property type="entry name" value="SUBTILISIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="SSF52743"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00136">
        <property type="entry name" value="SUBTILASE_ASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00137">
        <property type="entry name" value="SUBTILASE_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00138">
        <property type="entry name" value="SUBTILASE_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 5 9" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0720">Serine protease</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014734754" evidence="6">
        <location>
            <begin position="48"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="domain" description="Inhibitor I9" evidence="8">
        <location>
            <begin position="54"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_S8" evidence="7">
        <location>
            <begin position="179"/>
            <end position="464"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF05922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PJN06044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="498" mass="52207" checksum="6C91B4E377F32F02" modified="2018-04-25" version="1">MPRARSAGPGGYDQRNRMNRLGRRTALSISCLLLSSLAGLPLHTAAAAEDERGYVVVLKDSVADPKAAASRQTRAYGGSGATVVYGHALKGYAATMTPAQATALEKDPQVRFVAAQRTYKVSPPPQPVSPPPLPAPPLRDCQEVLDDVPPIRQCQPVFVDRVRADRSSARSGNGKGSVDVNVAVLDSGIAADVPDLNVQGGVDCLSGSPVFPGTSLQDPSGHGTMVAGIIGGRDDDQGLVGVAPGTPQWAVKVADDDQGLITDAALLCGIDWVVSTRTDADPDNDIALFNMSLGSESTPTEKDDGQCGVVNQDPLHLAICNTVAAGVTPVASAGNEHADVASVIPAAYDEVITTTAMADFDGRPGAKVAPICYGRDFGFFGDADDEASLPFSNFARSAADRKHTVAAPGVCNESNFPLPHHHAFGDGTSFAAPVVSGVLALCIDTRRCGSSSPARNVRELVNDARKYNDHDRRYGFFGDPHRPIPGRYYGPLIAADRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JHD5</accession>
    <name>A0A2M9JHD5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CG723_40255</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000033">
        <property type="protein sequence ID" value="PJN06253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN06253">
        <property type="protein sequence ID" value="PJN06253"/>
        <property type="gene ID" value="CG723_40255"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PJN06253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="114" mass="12396" checksum="77A667DB750CAC1D" modified="2018-04-25" version="1">MAEPEFTATGVRIGRLLRSLTRAGEVRIKGGRLELLTSYGSEIDSAPLQEVRAGKAWFAPGDRALADVGGRRYLLKLGDDHEPGDAVPRLVGESGPPTTRRFLDAVRRARGRLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JHH5</accession>
    <name>A0A2M9JHH5_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Carrier domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CG723_39985</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000032">
        <property type="protein sequence ID" value="PJN06325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN06325">
        <property type="protein sequence ID" value="PJN06325"/>
        <property type="gene ID" value="CG723_39985"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="SSF47336"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="3">
        <location>
            <begin position="131"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="32"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="1">
        <location>
            <position position="165"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PJN06325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="208" mass="20276" checksum="B719BD6292133EF6" modified="2018-04-25" version="1" fragment="single">EADTLAAWAAGEQVDWPPIAAAKAALPATPLTRTRYPLPTGPTGPTGPIASAAPTGPIASAASTGPAASTGPAGPTAVAAPAAAPLPAPAPEAVDTLSARLGSVWGIGLAEESAPAACAAPSGAGAEPAAAAPFTRLSRIVAAELGTDTGQLRPEQDLFALGATSRQLLRLAARIAADGGRELPLETLFTAADLGDLADQAFPTPVTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JHJ1</accession>
    <name>A0A2M9JHJ1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">FMN reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_39480</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000031">
        <property type="protein sequence ID" value="PJN06348.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN06348">
        <property type="protein sequence ID" value="PJN06348"/>
        <property type="gene ID" value="CG723_39480"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005025">
        <property type="entry name" value="FMN_Rdtase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03358">
        <property type="entry name" value="FMN_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52218">
        <property type="entry name" value="SSF52218"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014741143" evidence="1">
        <location>
            <begin position="25"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="domain" description="FMN_red" evidence="2">
        <location>
            <begin position="4"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN06348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="186" mass="19127" checksum="E1D3FF6CCEDB5FD2" modified="2018-04-25" version="1">MSVRILALVGSLRAGSHNRQLAEAAAKHAPAGVDIQLFDGLADVPFYNEDIDVEGSVPAGAARLREAAGQTDAFLLFSPEYNGTMPAVLKNAIDWLSRPYGAGAISGKPVAVVGTAFGQYGGVWAQDDVRKAAGIAGAAVLEDVKLSIPGSVTRFAETHPADDSEVATALTEVVGRLSEQATPAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JHS2</accession>
    <name>A0A2M9JHS2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CG723_39205</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000030">
        <property type="protein sequence ID" value="PJN06436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN06436">
        <property type="protein sequence ID" value="PJN06436"/>
        <property type="gene ID" value="CG723_39205"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025832">
        <property type="entry name" value="GxGYxYP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038410">
        <property type="entry name" value="GxGYxYP_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032626">
        <property type="entry name" value="GxGYxYP_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14323">
        <property type="entry name" value="GxGYxYP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16216">
        <property type="entry name" value="GxGYxYP_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014773736" evidence="1">
        <location>
            <begin position="31"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="domain" description="GxGYxYP_N" evidence="3">
        <location>
            <begin position="65"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="domain" description="GxGYxYP_N" evidence="3">
        <location>
            <begin position="331"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="domain" description="GxGYxYP_C" evidence="2">
        <location>
            <begin position="441"/>
            <end position="664"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF16216"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PJN06436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="669" mass="72999" checksum="00A03A5393D92DD4" modified="2018-04-25" version="1">MVSRRNLLQAGGAVLAAGSLGISLPQQAGAAERGSAARLLPSFGRAARLDVADVSKLNGNDQLLLTTLQGVVNRRSPRLYFNFDSGQVDLRWLAGTGAKATHHADALDLVGRYRDEVRGAVLIDPDVPDSVNVATTLAGLHGAVAATAEQAKAHGLKTVTDLRGRFDADDVLATYRWQLDHLFPHCSHALLAGLPPSRTVGVDGVKWREVARETERIRDISNRKVRTLDLSPELGGDNDVYLRFQDSFGDDGWGASVASVTVKADGKDIASFTPGTDAEKPYLFDGLNSSIGDKSNRFSDGGGYFVYHFTAPAGAKELTVDVDLWNQYLVTTTNTAPTRVEPFPYFRDYVVASKAMVLWLPPSGDTGKLLDETFSKAKPTTPYTGWFSNDVAGEWGGVDRASQHGIQVVPADFYMNGTVHAGTPAKISDRVRPRPKAELHNRVYVTLTVGEGDNVQYCQRRMRDIWDDPKRGTVPVNWTVSPLLADIGPALLAYYQRTATANDLLISGPSGAGYTYPGSWPEEALDAYTALSGRFLRRTGMDLAYAYNPRNTAGDGWVPFDERIMASYRKNTPVRGIIQSWETGDLQVRPAGIPVIGNFYPQGKGKEFRDALLRHIEGRDTSKPMFIAAAINAWDWTPSDIADLAALLEDPFEVVRGDAFFSLMDRSTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JIA5</accession>
    <name>A0A2M9JIA5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CG723_38460</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CB01635</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000028">
        <property type="protein sequence ID" value="PJN06583.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN06583">
        <property type="protein sequence ID" value="PJN06583"/>
        <property type="gene ID" value="CG723_38460"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004638">
        <property type="entry name" value="EmrB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00711">
        <property type="entry name" value="efflux_EmrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="21"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="65"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="89"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="114"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="147"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="174"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="209"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="240"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="276"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="309"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="339"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="370"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="413"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="473"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="23"/>
            <end position="504"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PJN06583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="518" mass="52741" checksum="9309A16110F52F44" modified="2018-04-25" version="1">MVTVTKQDSPQDSVQRDPRRWWALGALVASMLVLGFDMTILNVALPTIAADLGADTGQQQWMADSYVVVFAALMLPAGLLGDRFGRRRMLIAGLGVFLAGSLVGALASDVGWVVGARALMGVGAALVMPLALSVLPSLFAPDERTKAVGIISAASAVGMPLGPILGGWLLDHFWWGSVFLINIPMVAIGITACLFLLPETRDPASPRVDAVSTALTAAGLGALIYAIIEAPHRGWTDPVVLVLCAASVALVTALVLRERRSERPLLDLALLARRGFLLNTLAATLGMFVLSGLMFVLPQYLQAVLGNDALGTGVRLLPMMAGMLVAAKCAQPLVARFGPPAVISGALTVLAFAAFLGSRTTADSGYGFTALWLGIAGVGFSFALVPAMGAALSALPADRAGSGSGLLMTVRQVGGALGIALLGALLAGAYGSRLDTGGLPGPAADTAKDSVVAAHAVATKLGDHALASSANTAYVHGMSVVLLVVGVASLVTALLAAALLPRTAPATGVAPVPGDARE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JID0</accession>
    <name>A0A2M9JID0_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF1330 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_38560</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000028">
        <property type="protein sequence ID" value="PJN06602.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN06602">
        <property type="protein sequence ID" value="PJN06602"/>
        <property type="gene ID" value="CG723_38560"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010753">
        <property type="entry name" value="DUF1330"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07045">
        <property type="entry name" value="DUF1330"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF1330" evidence="1">
        <location>
            <begin position="2"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN06602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="117" mass="12918" checksum="9511763CC20948B8" modified="2018-04-25" version="1">MTAYAIAALRNTTVPNEEVFDYMERIQSTLDPFGGRFLVHGARLEDIEGSWPGGVVVISFPDKAAVHGWYESDAYQELIPLRTRNLEGELIFVEGVPGDYDPSTTAARMRAEAGRGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JIK3</accession>
    <name>A0A2M9JIK3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">FAD-binding dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CG723_38065</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000027">
        <property type="protein sequence ID" value="PJN06682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN06682">
        <property type="protein sequence ID" value="PJN06682"/>
        <property type="gene ID" value="CG723_38065"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033765">
        <property type="term" value="F:steroid dehydrogenase activity, acting on the CH-CH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008202">
        <property type="term" value="P:steroid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.700.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003953">
        <property type="entry name" value="FAD-binding_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027477">
        <property type="entry name" value="Succ_DH/fumarate_Rdtase_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014614">
        <property type="entry name" value="UCP036654"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43260">
        <property type="entry name" value="PTHR43260"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00890">
        <property type="entry name" value="FAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036654">
        <property type="entry name" value="UCP036654"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD_binding_2" evidence="3">
        <location>
            <begin position="7"/>
            <end position="536"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PJN06682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="555" mass="59914" checksum="7C2C9C3735566DFE" modified="2018-04-25" version="1">MTTYDADVIVIGAGLAGLAAVAELVDAGRKVILLDQEPEQSIGGQAHWSFGGLFFVDSPEQRRLRIKDSHALALQDWMGTAGFDRAEDHWPRKWAEAYVDFAAGEKRSWLHQQGVRFFPVVGWAERGGYDANGHGNSVPRFHITWGTGPGLVAPFERRVREGVARGLVQLKFRHRVTGLSRSAGAVDTVSGEILEPSSIERGQGSSRTVTGSFELKAQAVIVTSGGIGGNHDLVRANWPERLGTPPEKMLSGVPAHVDGLMLGITEDAGAHLINRDRMWHYTEGIENWNPIWDKHGIRILPGPSSLWLDARGERLPVPLFPGFDTLGTLDHIMKTGYGYTWFVLNQRIIGKEFTLSGSEQNPDLTGKSVRGVIDRARADVPAPVKAFMDNGADFVVEKDLPALVRGMNALTEKSSGPLIDEAALRRTLVARDREIVNPFTKDLQVTAIRGTRKFLGDRLIRTTAPHRILDPKAGPLVAVRLNILTRKSLGGLETDLSSRVLTDAGEPLPGVYAAGEAAGFGGGGVHGYRSLEGTFLGGCLFSGRAAGRAAAAATG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JIY1</accession>
    <name>A0A2M9JIY1_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF1524 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CG723_36715</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000025">
        <property type="protein sequence ID" value="PJN06829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN06829">
        <property type="protein sequence ID" value="PJN06829"/>
        <property type="gene ID" value="CG723_36715"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011089">
        <property type="entry name" value="DUF1524"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07510">
        <property type="entry name" value="DUF1524"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014780111" description="DUF1524 domain-containing protein" evidence="2">
        <location>
            <begin position="26"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="domain" description="DUF1524" evidence="3">
        <location>
            <begin position="77"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="215"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07510"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PJN06829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="237" mass="25039" checksum="A1DC8F5EA07F90C0" modified="2018-04-25" version="1">MRGAGRAVAAVLVTVAVATGCTVEQQGGSGSGPEYKAGGALDAVNSLTVKGRAPKTGYDRGRFGSAWADTDSNGCDTRDDILKRDLTGVKFRDGRCTVVSGTLASDPYTGKEIAFARGRSQVDIDHLVALSDAWQKGAQKWDPSKRIALANDPLNLLAVDAGPNRSKGEGDTATWLPPRKGYRCTYVAGQVAVKKKYGLWVTAGERDAMKRVLSSCPDQALPTGGNPTSAPERFHAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JJ41</accession>
    <name>A0A2M9JJ41_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycosyl transferase family 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_37055</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000025">
        <property type="protein sequence ID" value="PJN06888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN06888">
        <property type="protein sequence ID" value="PJN06888"/>
        <property type="gene ID" value="CG723_37055"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_2-like" evidence="1">
        <location>
            <begin position="13"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN06888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="342" mass="36778" checksum="39DD1C0C51877AB3" modified="2018-04-25" version="1">MNANSDKQLPPVSVIMPVLNEERHLRGAVEAILAQEYGGEMEVVVALGPSSDRTDEIAAELVREDPRVHTVANPTGRTPAALNAAIEASRHPIVVRVDGHGMLSPNYIATAVRLLEETGAQNVGGIMHAEGENDWENAVAAAMTSKIGVGNAAFHTGGEAQQAETVFLGVFRREALEQQGGYNVEFIRAQDWELNFRIREAGGLIWFSPELKVSYRPRPSVKALAKQYKDYGRWRHVVARYHEGSINLRYLAPPAAVCAIAAGVVVGALVTPWGFVIPGGYLAAIVAGSVPAGKGLSLKARLQIPVALATMHMSWGWGFLTSPRSLAKKVIASRRPAVLSEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JJL1</accession>
    <name>A0A2M9JJL1_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1 2">Hypoxanthine phosphoribosyltransferase</fullName>
            <ecNumber evidence="1 2">2.4.2.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">hpt</name>
        <name evidence="4" type="ORF">CG723_35660</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CB01635</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>diphosphate + IMP = 5-phospho-alpha-D-ribose 1-diphosphate + hypoxanthine</text>
            <dbReference type="Rhea" id="RHEA:17973"/>
            <dbReference type="ChEBI" id="CHEBI:17368"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
            <dbReference type="EC" id="2.4.2.8"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Purine metabolism; IMP biosynthesis via salvage pathway; IMP from hypoxanthine: step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the purine/pyrimidine phosphoribosyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.8" evidence="1 2"/>
    <dbReference type="EMBL" id="NNBL01000023">
        <property type="protein sequence ID" value="PJN07069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN07069">
        <property type="protein sequence ID" value="PJN07069"/>
        <property type="gene ID" value="CG723_35660"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00591">
        <property type="reaction ID" value="UER00648"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052657">
        <property type="term" value="F:guanine phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004422">
        <property type="term" value="F:hypoxanthine phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032264">
        <property type="term" value="P:IMP salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006166">
        <property type="term" value="P:purine ribonucleoside salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005904">
        <property type="entry name" value="Hxn_phspho_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRibTrfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00156">
        <property type="entry name" value="Pribosyltran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="SSF53271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01203">
        <property type="entry name" value="HGPRTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="2" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2" id="KW-0660">Purine salvage</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pribosyltran" evidence="3">
        <location>
            <begin position="21"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU364099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PJN07069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="186" mass="20112" checksum="222ABF94F4EB3F58" modified="2018-04-25" version="1">MRVDAKDMGTDLQSVLITKEEIDAKLAELAAKIDAEYAGKDLLIVGVLKGAVMVMADLARALSTPVTMDWMAVSSYGAGTQSSGVVRILKDLDTDIKGRHVLIVEDIIDSGLTLSWLLTNLGTREPASLEVCTLLRKPEAAKVAIDVKWTGFEIPNEFVVGYGLDYAEKYRNLPFVGTLAPHVYGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JJQ8</accession>
    <name>A0A2M9JJQ8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Esterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_35975</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000023">
        <property type="protein sequence ID" value="PJN07125.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN07125">
        <property type="protein sequence ID" value="PJN07125"/>
        <property type="gene ID" value="CG723_35975"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="5"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN07125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="239" mass="25284" checksum="03BC8C2AE7368967" modified="2018-04-25" version="1">MTDYVLVAGAWLGAWAWDDVVPDLRAAGHGAHAVTLTGVADKQGVPAGQKTHVQDIVDEVERLGLRDVVLVGHSYSGIPVGQAAERIGDRLRRVVFVDSSVPADGESFVSAWWQGPAALEAALAANDGDWPPLTAPECEGQGLDDAQIARFVSGATPHPGASLSEPAVLSRPLGELPATYIKCLLDGPEPSDDVAELLRGEGWRLREMDTGHWPMFSRPRELARILLEEAGASSGSQAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JK47</accession>
    <name>A0A2M9JK47_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CG723_35210</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000022">
        <property type="protein sequence ID" value="PJN07240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN07240">
        <property type="protein sequence ID" value="PJN07240"/>
        <property type="gene ID" value="CG723_35210"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021398">
        <property type="entry name" value="DUF3037"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11236">
        <property type="entry name" value="DUF3037"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PJN07240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="129" mass="14134" checksum="BEAEA9324664B5DF" modified="2018-04-25" version="1">MTATSRDVFEYALLRVVPRVERGEQINAGVVVYCRARSYVRALTHLDEAKLRALDPEADVTGVRASLAAVERHCRGGGDAGQAADDDAGRRFRWLVAPRSTVVQPGPVHTGLTEDPEAEVDRLLDLLVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JK91</accession>
    <name>A0A2M9JK91_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">30S ribosomal protein S4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">rpsD</name>
        <name evidence="10" type="ORF">CG723_34070</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CB01635</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit.</text>
    </comment>
    <comment type="function">
        <text evidence="6">With S5 and S12 plays an important role in translational accuracy.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Part of the 30S ribosomal subunit. Contacts protein S5. The interaction surface between S4 and S5 is involved in control of translational fidelity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6 7">Belongs to the universal ribosomal protein uS4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000021">
        <property type="protein sequence ID" value="PJN07284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN07284">
        <property type="protein sequence ID" value="PJN07284"/>
        <property type="gene ID" value="CG723_34070"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00165">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01306_B">
        <property type="entry name" value="Ribosomal_S4_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022801">
        <property type="entry name" value="Ribosomal_S4/S9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001912">
        <property type="entry name" value="Ribosomal_S4/S9_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005709">
        <property type="entry name" value="Ribosomal_S4_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018079">
        <property type="entry name" value="Ribosomal_S4_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002942">
        <property type="entry name" value="S4_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036986">
        <property type="entry name" value="S4_RNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11831">
        <property type="entry name" value="PTHR11831"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11831:SF4">
        <property type="entry name" value="PTHR11831:SF4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00163">
        <property type="entry name" value="Ribosomal_S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01479">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01390">
        <property type="entry name" value="Ribosomal_S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00363">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01017">
        <property type="entry name" value="rpsD_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00632">
        <property type="entry name" value="RIBOSOMAL_S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6 7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 6 7" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3 6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 6" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="Ribosomal_S4" evidence="9">
        <location>
            <begin position="3"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="domain" description="S4" evidence="8">
        <location>
            <begin position="92"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM01390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PJN07284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="204" mass="23581" checksum="099DB9A504369907" modified="2018-04-25" version="1">MTNQSRPKVKKSRALGIALTPKAVKYFEARPYPPGEHGRGRKQNSDYKVRLLEKQRLRAQYDVSERQLVRAYERAAKTQLKTGEALVIELERRLDALVLRSGIARTIYQARQMVVHGHIEVNGGKVDKPSYRVRPDDVVMVRERSREKPLFQVAREGGFAPDGEIPRYLQVNLKALAFRLDRDPNRKEIPVICDEQLVVEYYAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JKA9</accession>
    <name>A0A2M9JKA9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">30S ribosomal protein S13</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_34190</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000021">
        <property type="protein sequence ID" value="PJN07306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_026246651.1">
        <property type="nucleotide sequence ID" value="NZ_NNBL01000021.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN07306">
        <property type="protein sequence ID" value="PJN07306"/>
        <property type="gene ID" value="CG723_34190"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010979">
        <property type="entry name" value="Ribosomal_S13-like_H2TH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46946">
        <property type="entry name" value="SSF46946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN07306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="107" mass="11539" checksum="22A884F8E455FE2C" modified="2018-04-25" version="1">MALPPLTPEQRAAALEKAAAARRERAEVKNRLKHSGASLHEVIKQGQENDVIGKMKVSALLESLPGVGKVRAKQIMERLGISESRRVRGLGSNQIASLEREFGSTGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JKD3</accession>
    <name>A0A2M9JKD3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Riboflavin synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CG723_34325</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000021">
        <property type="protein sequence ID" value="PJN07331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN07331">
        <property type="protein sequence ID" value="PJN07331"/>
        <property type="gene ID" value="CG723_34325"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00402">
        <property type="entry name" value="Riboflavin_synthase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023366">
        <property type="entry name" value="ATP_synth_asu-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001783">
        <property type="entry name" value="Lumazine-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026017">
        <property type="entry name" value="Lumazine-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21098">
        <property type="entry name" value="PTHR21098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00677">
        <property type="entry name" value="Lum_binding"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000498">
        <property type="entry name" value="Riboflavin_syn_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="SSF63380"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00187">
        <property type="entry name" value="ribE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51177">
        <property type="entry name" value="LUMAZINE_BIND"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="Lumazine-binding" evidence="2">
        <location>
            <begin position="1"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="domain" description="Lumazine-binding" evidence="3">
        <location>
            <begin position="1"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="repeat" description="Lumazine-binding" evidence="2">
        <location>
            <begin position="97"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="domain" description="Lumazine-binding" evidence="3">
        <location>
            <begin position="97"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PJN07331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="202" mass="21384" checksum="6093A06C7ADC7428" modified="2018-04-25" version="1">MFTGIVEELGEITAVEELGDASRFRLRGPVVTEGARHGDSIAVNGVCLTVVEHEGDEFTADVMAETLDRSSLGALAVGSRVNLERPTAVGARLGGHIVQGHVDGTGSIVERKPSENWEIVKVSLPAHLARYVVEKGSITVDGVSLTVVDAGPDYFTISLIPTTLALTTLGLKQAGDPVNLEVDVIAKYVERLLGDRAQEATK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JL77</accession>
    <name>A0A2M9JL77_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">UPF0232 protein CG723_33230</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CG723_33230</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CB01635</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the UPF0232 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000019">
        <property type="protein sequence ID" value="PJN07630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN07630">
        <property type="protein sequence ID" value="PJN07630"/>
        <property type="gene ID" value="CG723_33230"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00630">
        <property type="entry name" value="UPF0232"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007922">
        <property type="entry name" value="DUF721/UPF0232"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023007">
        <property type="entry name" value="UPF0232_actinobac"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05258">
        <property type="entry name" value="DciA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="27"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PJN07630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="180" mass="19215" checksum="F0BF89C7E0D383A5" modified="2018-04-25" version="1">MTENTSGDAPQKAPEPSGVDLARVALRAAKEQARARGVADQQKKQARRGGGLRSGARADGRDPVAFGAAINRLITERGWEAPAAVGGVMGRWPEIVGEDLAKHSEPLKYDEDERVLTVQCDSTAWAMQLRYLAPTLVARLNEDLGHGTVRLLKILGPNAPARRFGPLRAPGSKGPGDTYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JLG5</accession>
    <name>A0A2M9JLG5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">rRNA methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_32095</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000018">
        <property type="protein sequence ID" value="PJN07714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN07714">
        <property type="protein sequence ID" value="PJN07714"/>
        <property type="gene ID" value="CG723_32095"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008173">
        <property type="term" value="F:RNA methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1280.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029028">
        <property type="entry name" value="Alpha/beta_knot_MTases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029064">
        <property type="entry name" value="L30e-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001537">
        <property type="entry name" value="SpoU_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029026">
        <property type="entry name" value="tRNA_m1G_MTases_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00588">
        <property type="entry name" value="SpoU_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55315">
        <property type="entry name" value="SSF55315"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75217">
        <property type="entry name" value="SSF75217"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SpoU_methylase" evidence="1">
        <location>
            <begin position="124"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN07714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="275" mass="29893" checksum="A91D9C027CBCE2CD" modified="2018-04-25" version="1">MAEAQGLITIEDPDDPRLRDYTGLTDVELRRRREPAEGLFIAEGEKVIRRAKQAGYEMRSMLLSAKWVDVMRDVIDEVPAPVYAVSPDLAERVTGYHVHRGALASMQRKPLPTADELLATQRRVVVMEAVNDHTNIGAIFRSAAALGMDAVLLSPDCADPLYRRSVKVSMGAVFSVPYARLESWPKSLESVREAGFSLLALTPDEKAKSLDEVAPHKMDRVALMLGAEGDGLSTQALVAADEWVRIPMAHGVDSLNVGAAAAVAFYAVATGRPQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JLH5</accession>
    <name>A0A2M9JLH5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GNAT family N-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_32150</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000018">
        <property type="protein sequence ID" value="PJN07724.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN07724">
        <property type="protein sequence ID" value="PJN07724"/>
        <property type="gene ID" value="CG723_32150"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13673">
        <property type="entry name" value="Acetyltransf_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="5"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN07724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="165" mass="17804" checksum="038D565C4460ED6C" modified="2018-04-25" version="1">MGMSVIISAATEQDAEKILKLQYLCYQSEAELYGDYSIEPLTEPLASVRAELAGGTVLVARLGEEVVAAVRGAVDADGTARIGKLVVHPRMQRHGLGGRLLDAVEAKLGVDGAAKRFQLFTGHRSEHNLRLYRKHGYAAVSTKRVDERLTVVTLTKEAEAGAFVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JLL0</accession>
    <name>A0A2M9JLL0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Type VII secretion-associated serine protease mycosin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">mycP</name>
        <name evidence="14" type="ORF">CG723_32370</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">CB01635</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the peptidase S8 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000018">
        <property type="protein sequence ID" value="PJN07766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN07766">
        <property type="protein sequence ID" value="PJN07766"/>
        <property type="gene ID" value="CG723_32370"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000209">
        <property type="entry name" value="Peptidase_S8/S53_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023827">
        <property type="entry name" value="Peptidase_S8_Asp-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015500">
        <property type="entry name" value="Peptidase_S8_subtilisin-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023834">
        <property type="entry name" value="T7SS_pept_S8A_mycosin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00082">
        <property type="entry name" value="Peptidase_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00723">
        <property type="entry name" value="SUBTILISIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="SSF52743"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03921">
        <property type="entry name" value="T7SS_mycosin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00136">
        <property type="entry name" value="SUBTILASE_ASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 14" id="KW-0645">Protease</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0720">Serine protease</keyword>
    <keyword evidence="12" id="KW-0732">Signal</keyword>
    <keyword evidence="6 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014650727" evidence="12">
        <location>
            <begin position="32"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="362"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_S8" evidence="13">
        <location>
            <begin position="55"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="PJN07766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="389" mass="39982" checksum="E0ABE6FF45B8348F" modified="2018-04-25" version="1">MTRTAAAWRNAATALTAAAALALLPSTTAHADSVRAQQWGLDAMHTEDAWRTTKGKGITVAVLDTGVDGTHPDLKGNVLPIKDLVGFGAKRGDRSWARHGTAMAGIIAGHGHGPGGDDGVLGIAPEAKVLPVRVILEDGDPARKEARSSRGSALADGIRWAADHGADVINLSLGDDSATAHPEATEDAAVQYALKKGSVVVASAGNGGKKGDHISYPAAYPGVITATAVDRYLHRAPFSTRRWYATVSAPGDAIAIADPDRTYYSGWGTSAASAFVSGAVALVRAAHPGLTPAQIKQLLEDTARDAPSGGRDDSLGFGFVDPAAAIRKGDSLKAEGLRSTTYSEKFFGTGPDTPDGDAGTGWVGPVAGGLGVVLLAAAVYLWRGRRTVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JLY7</accession>
    <name>A0A2M9JLY7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CG723_31250</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000017">
        <property type="protein sequence ID" value="PJN07875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN07875">
        <property type="protein sequence ID" value="PJN07875"/>
        <property type="gene ID" value="CG723_31250"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PJN07875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="321" mass="36499" checksum="DE60794C272213A2" modified="2018-04-25" version="1">MGHESKKRSAYKGTSSKAILHQYDFLGDFYRLTLGPELVFSYGMWEEGDTLDSAQIRKLDYHAEAAHTDGADHVLDIGCGYGSLLHRLVKNHHVKHAVGITMSPGQAAWARDQHWPGCEVRAENWFDHEPDRPYDAIIAIEVMEHCAGNTMWRAKRVARYREFFQHCHSWLRPAGRLSVQVNAWNERGWLASLVLPPQQLDPHRSGVRERLGLKDILGGIKNVREGLHASRKVYPECFLPTLDELIEASRGLFSIVEARSDPDDGVATVRSWLERAEANHVRGAELIGESAVSDIIREQKTALRFLREGRFTVVRMVFEKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JM10</accession>
    <name>A0A2M9JM10_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CG723_31560</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000017">
        <property type="protein sequence ID" value="PJN07916.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN07916">
        <property type="protein sequence ID" value="PJN07916"/>
        <property type="gene ID" value="CG723_31560"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PJN07916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="72" mass="7914" checksum="7B4EB4DB81DE607F" modified="2018-04-25" version="1">MDPEDAGTKAKFVIRDRDAKYPAVIDEVLAGAGIRTILTSIRMPCMNSVMDADQQSGAPEREVLHRRYAHAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JME0</accession>
    <name>A0A2M9JME0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">IS200/IS605 family transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_30620</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000016">
        <property type="protein sequence ID" value="PJN08041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08041">
        <property type="protein sequence ID" value="PJN08041"/>
        <property type="gene ID" value="CG723_30620"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1290">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002686">
        <property type="entry name" value="Transposase_17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036515">
        <property type="entry name" value="Transposase_17_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01797">
        <property type="entry name" value="Y1_Tnp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01321">
        <property type="entry name" value="Y1_Tnp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143422">
        <property type="entry name" value="SSF143422"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Y1_Tnp" evidence="1">
        <location>
            <begin position="8"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM01321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN08041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="132" mass="15332" checksum="CFEB00184EF7854B" modified="2018-04-25" version="1">MRRGAHVVYNLHVHLVFVTKYRRGMMDDAMLTRCEEILREVCGSFDAELKEFNGERDHVHLLVHYPPKVTLSKLVNSLKGVSSRYLRQEFTGQANRAIMHGRFWSRSYFAGSCGGAPISVVRQYIEQQKRPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-06-02" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JMH3</accession>
    <name>A0A2M9JMH3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DUF4442 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CG723_30725</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CB01635</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the thioesterase PaaI family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000016">
        <property type="protein sequence ID" value="PJN08058.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08058">
        <property type="protein sequence ID" value="PJN08058"/>
        <property type="gene ID" value="CG723_30725"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047617">
        <property type="term" value="F:acyl-CoA hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039298">
        <property type="entry name" value="ACOT13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003736">
        <property type="entry name" value="PAAI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006683">
        <property type="entry name" value="Thioestr_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21660">
        <property type="entry name" value="PTHR21660"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03061">
        <property type="entry name" value="4HBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="SSF54637"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00369">
        <property type="entry name" value="unchar_dom_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4HBT" evidence="3">
        <location>
            <begin position="64"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PJN08058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="160" mass="17168" checksum="5D6FC90FF41ECAB8" modified="2018-04-25" version="1">MSDEGEHVAGHEQQEQASTEVQERIRASFARQGLMAHLGARLTRIAPGVVHIALPARPEVTQQHGYFHAGATSAVADSAGGYAAFTLFPENTEVLTVEYKINLLAPALGDHLEAIGTVLKAGRTLTVCQLEVFAAQDDGTRKLVANGQQTLIRVNRTAEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JMN7</accession>
    <name>A0A2M9JMN7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_29425</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000015">
        <property type="protein sequence ID" value="PJN08129.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08129">
        <property type="protein sequence ID" value="PJN08129"/>
        <property type="gene ID" value="CG723_29425"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="31"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="59"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="82"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="121"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="156"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="161"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN08129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="180" mass="18539" checksum="CD40F964DA082363" modified="2018-04-25" version="1">MYRASGKGGVKAPRPVPPVVLALRRFPDPRLTGLGSGLFCAAAMFALACLDALLFGGSIVVYGVLFLLVSALTAMWVRRADLVAAPVAVPIGFAVGILPVADGSGGFGGQVMGLVTALAMHAGWLYGGTLVAGLVVTVRGIRHMARRAARRRALAQARAGSPGTPAQQVTSAPRPRRRTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JMX0</accession>
    <name>A0A2M9JMX0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">TetR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_29905</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000015">
        <property type="protein sequence ID" value="PJN08218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08218">
        <property type="protein sequence ID" value="PJN08218"/>
        <property type="gene ID" value="CG723_29905"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045823">
        <property type="entry name" value="TetR_C_32"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19344">
        <property type="entry name" value="TetR_C_32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="20"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="43"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN08218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="213" mass="23281" checksum="4A7A948919754C69" modified="2018-04-25" version="1">MTAIEQTEAARPRGTRLPRRARRNQLLGAAQEVFVAQGYHAAAMDDIAERAGVSKPVLYQHFPGKLDLYLALLDQHCEALLLAVRTALASTSDNKQRVAATMDAYFAYVEDEGGAFRLVFESDLTNEPAVRERVDRVSLQCAEAISDVIAEDTGLSKDESMLLAVGLGGVSQVVARYWLSSKSTMPRDKAVQLLTSLAWRGIAGFPLHGTDHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JMY0</accession>
    <name>A0A2M9JMY0_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">50S ribosomal subunit assembly factor BipA</fullName>
            <ecNumber evidence="2">3.6.5.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">GTP-binding protein BipA</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">typA</name>
        <name evidence="2" type="synonym">bipA</name>
        <name evidence="4" type="ORF">CG723_29620</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CB01635</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">A 50S ribosomal subunit assembly protein with GTPase activity, required for 50S subunit assembly at low temperatures, may also play a role in translation. Binds GTP and analogs. Binds the 70S ribosome between the 30S and 50S subunits, in a similar position as ribosome-bound EF-G; it contacts a number of ribosomal proteins, both rRNAs and the A-site tRNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>GTP + H2O = GDP + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="2">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <text evidence="2">Binds to ribosomes.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. BipA subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.5.-" evidence="2"/>
    <dbReference type="EMBL" id="NNBL01000015">
        <property type="protein sequence ID" value="PJN08167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08167">
        <property type="protein sequence ID" value="PJN08167"/>
        <property type="gene ID" value="CG723_29620"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03710">
        <property type="entry name" value="BipA_TypA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.250">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00849">
        <property type="entry name" value="BipA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035651">
        <property type="entry name" value="BipA_V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035647">
        <property type="entry name" value="EFG_III/V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000640">
        <property type="entry name" value="EFG_V-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004161">
        <property type="entry name" value="EFTu-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031157">
        <property type="entry name" value="G_TR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042116">
        <property type="entry name" value="TypA/BipA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006298">
        <property type="entry name" value="TypA_GTP-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42908:SF8">
        <property type="entry name" value="PTHR42908:SF8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00679">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03144">
        <property type="entry name" value="GTP_EFTU_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="SSF50447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54980">
        <property type="entry name" value="SSF54980"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01394">
        <property type="entry name" value="TypA_BipA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00301">
        <property type="entry name" value="G_TR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2" id="KW-0699">rRNA-binding</keyword>
    <keyword evidence="2" id="KW-0820">tRNA-binding</keyword>
    <feature type="domain" description="Tr-type G" evidence="3">
        <location>
            <begin position="5"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="17"/>
            <end position="22"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="138"/>
            <end position="141"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PJN08167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="624" mass="68441" checksum="B812F8E04A016183" modified="2018-04-25" version="1">MATRHDIRNVAIVAHVDHGKTTLVDAMLKQAGAFAAHAAESLDDRMMDSNDLEREKGITILAKNTAVKYHPKDGGDAITINIIDTPGHADFGGEVERGLSMVDAVVLLVDASEGPLPQTRFVLRKALSAKMPVILCINKTDRPDSRIAEVVDETYDLFLDLDADEDQIEFPIVYACARDGVASLTKPEDGTVPQDSENLEPFFNTILAHVPAPEFDEAAPLQAHVTNLDADNFLGRIALCRVEQGELRKGQTVTWIKRDGTMSNVRITELLMTEALTRKPAEMAGPGDICAIAGIPDIMIGETLADTENPIALPLITVDEPAISMTIGANTSPLVGKGGKGHKVTARQIKDRLDRELVGNVSLRVLDTERPDAWEVQGRGELALAILVEQMRREGFELTVGKPEVVTKQVNGKTHEPIERMTIDSPEEHLGAITQLMATRKGRMETMTNHGSGWVRMEWIVPSRGLIGFRTEFLTQTRGTGIAHSIFEGHEPWFGDLRTRHNGSLVADRSGTVTPFAMVNLQERGVIFTEAGTEVYEGMIIGENSRADDMDVNITKEKKLTNMRAASADTTENVVPARKLSLEQSLEFCRDDECIEVTPETVRIRKVVLDQKLRGRAASKAKNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-09-29" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JNJ5</accession>
    <name>A0A2M9JNJ5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_29145</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LOR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000014">
        <property type="protein sequence ID" value="PJN08442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08442">
        <property type="protein sequence ID" value="PJN08442"/>
        <property type="gene ID" value="CG723_29145"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007612">
        <property type="entry name" value="LOR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038595">
        <property type="entry name" value="LOR_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025659">
        <property type="entry name" value="Tubby-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04525">
        <property type="entry name" value="LOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54518">
        <property type="entry name" value="SSF54518"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN08442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="164" mass="19087" checksum="70C15E8FC6CD7852" modified="2018-04-25" version="1">MRYEVRERLFAVGEDYWIEDEQGHKAFLVDGKAMRLRDTFELKGPDGRVLIDIHEKMFALRDTMVIERGDEALAKIKRKRLSLLRNHYRVELADGTELDVSGKILDREFVVEYDGEMLAHISRRRLRVRDTYGVDVIREDADPALIIAVAVCVIRLAEKERGED</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JNJ9</accession>
    <name>A0A2M9JNJ9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cupin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_29130</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000014">
        <property type="protein sequence ID" value="PJN08439.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08439">
        <property type="protein sequence ID" value="PJN08439"/>
        <property type="gene ID" value="CG723_29130"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013096">
        <property type="entry name" value="Cupin_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07883">
        <property type="entry name" value="Cupin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cupin_2" evidence="2">
        <location>
            <begin position="39"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="108"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN08439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="133" mass="14720" checksum="B794160F09699A5B" modified="2018-04-25" version="1">MTTRENTPIALDEALASFDVLWSPRIVTRVNDYDVRVAKVEGDHVWHVHDDTDEFFLVVDGELTIALREPEGERDVVLPRGSVFTVPRGTWHKPRSPKGASILLLEPTGTPTVGDHHDDVPDHVDATTGHALA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JNQ7</accession>
    <name>A0A2M9JNQ7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_28425</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000014">
        <property type="protein sequence ID" value="PJN08485.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08485">
        <property type="protein sequence ID" value="PJN08485"/>
        <property type="gene ID" value="CG723_28425"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014818976" evidence="2">
        <location>
            <begin position="26"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="75"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN08485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="94" mass="9190" checksum="E9A556781AC8CB93" modified="2018-04-25" version="1">MKPLKAAAVVAGSMVIAGAAAPAFASDLTPTSLNGAIETLSHQSLLDAQPLHTNMLDTEQGGSVLNTVQDTADNVNDAGAGAPAGLLGGLPLGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JNZ0</accession>
    <name>A0A2M9JNZ0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glyoxalase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_27835</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000013">
        <property type="protein sequence ID" value="PJN08580.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08580">
        <property type="protein sequence ID" value="PJN08580"/>
        <property type="gene ID" value="CG723_27835"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041581">
        <property type="entry name" value="Glyoxalase_6"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18029">
        <property type="entry name" value="Glyoxalase_6"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glyoxalase_6" evidence="1">
        <location>
            <begin position="7"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="Glyoxalase_6" evidence="1">
        <location>
            <begin position="135"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF18029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN08580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="245" mass="26905" checksum="4FD4284990238CC6" modified="2018-04-25" version="1">MTLQLVQVNFKARDDSALGRFWAEVLGWGVSSEGPGVTNLEPEGFDWPDPSAVCVDLVRVPDPETVKYRVHIELATTSDAHQAELVARLKELGATTADVGQGEVPWTVMADPEGNVFSVLEPRELYRDTGPIAAVVVDCADPRAMVRFWGEAIDWTVHELTDDRALLRSVKGVGPYLEFRRTPDDRVVSNRIHLDVMSNPVEDQAREVTRLEGLGATRADVGQGDVSWVVLADPEGNEFCVLGRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JPE4</accession>
    <name>A0A2M9JPE4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">K+/H+ antiporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CG723_27025</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000012">
        <property type="protein sequence ID" value="PJN08739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08739">
        <property type="protein sequence ID" value="PJN08739"/>
        <property type="gene ID" value="CG723_27025"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005451">
        <property type="term" value="F:monovalent cation:proton antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006813">
        <property type="term" value="P:potassium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006153">
        <property type="entry name" value="Cation/H_exchanger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038770">
        <property type="entry name" value="Na+/solute_symporter_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030151">
        <property type="entry name" value="NhaP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006037">
        <property type="entry name" value="RCK_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036721">
        <property type="entry name" value="RCK_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32507:SF7">
        <property type="entry name" value="PTHR32507:SF7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00999">
        <property type="entry name" value="Na_H_Exchanger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02080">
        <property type="entry name" value="TrkA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF116726">
        <property type="entry name" value="SSF116726"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51202">
        <property type="entry name" value="RCK_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="30"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="60"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="85"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="115"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="145"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="205"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="295"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="321"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="359"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="385"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="domain" description="RCK C-terminal" evidence="5">
        <location>
            <begin position="425"/>
            <end position="506"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PJN08739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="530" mass="55563" checksum="DADC3D4BD7DB99AE" modified="2018-04-25" version="1">MVVPQRPVHPYGPSRTTFGGRKQPLTVHHLNQLLLVCSLVLLIAVAAVRISSRSGLPSLLLYLGIGVAMGQDGIGNVSFSNAELTQVIGYAALVVILAEGGLGTKWKDIRPALPAAVMLSTVGVAISVGVTAAGAHYVVGLEWRHALIIGAVVSSTDAAAVFSVLRKVPLPSRVTGVLEAESGFNDAPVVILVVAFSTAGPIEHWYALIGEITLELAIGAAIGIAVGWLGSFGLRHVALPASGLYPIAVMAIAVTAYAAGAMAHGSGFLAVYLASMVLGNAKLPHWPATRGFAEGLGWIAQIGMFVLLGLLVTPHDLVDDFWPAIVIGLVLTMVARPLSVVLSLLPFRMPWQEKALMSWAGLRGAVPIILATIPMVNGVEDSTRIFNIVFVLVVVYTLVQGPTLPWLARKLRLGSDSASAADLGIESAPLERLRGHLLSVTIPKESRMHGVEVSELRMPPGAAVTLVVREKQSFVPLPTTVLRHGDELLVVATDQVRDAAEARLRAVAQGGKLAGWLAGNGGPGRAGRAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JPS4</accession>
    <name>A0A2M9JPS4_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">ATP synthase subunit b</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">ATP synthase F(0) sector subunit b</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">ATPase subunit I</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">F-type ATPase subunit b</fullName>
            <shortName evidence="13">F-ATPase subunit b</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="primary">atpF</name>
        <name evidence="16" type="ORF">CG723_25660</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">CB01635</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0).</text>
    </comment>
    <comment type="function">
        <text evidence="11 13">F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="12 13">F-type ATPases have 2 components, F(1) - the catalytic core - and F(0) - the membrane proton channel. F(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). F(0) has three main subunits: a(1), b(2) and c(10-14). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. F(1) is attached to F(0) by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13">Cell membrane</location>
            <topology evidence="1 13">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13 14">Belongs to the ATPase B chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000011">
        <property type="protein sequence ID" value="PJN08883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08883">
        <property type="protein sequence ID" value="PJN08883"/>
        <property type="gene ID" value="CG723_25660"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045263">
        <property type="term" value="C:proton-transporting ATP synthase complex, coupling factor F(o)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01398">
        <property type="entry name" value="ATP_synth_b_bprime"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028987">
        <property type="entry name" value="ATP_synth_B-like_membr_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002146">
        <property type="entry name" value="ATP_synth_b/b'su_bac/chlpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005864">
        <property type="entry name" value="ATP_synth_F0_bsu_bac"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00430">
        <property type="entry name" value="ATP-synt_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81573">
        <property type="entry name" value="SSF81573"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01144">
        <property type="entry name" value="ATP_synt_b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 13" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="13" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 13 14" id="KW-0138">CF(0)</keyword>
    <keyword evidence="15" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6 13 14" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="8 13 14" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 13 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 13 14" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="24"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="15">
        <location>
            <begin position="47"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00025198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00025830"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01398"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU003848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="PJN08883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="182" mass="20122" checksum="8C563243F3F104AA" modified="2018-04-25" version="1">MIANLVALAAEEEQNPLIPPGPELLIGTLAFAIVFFFFAKKLLPRINKTLEERRELIEGGIEKAESAQTEAQSVLEQYKAQLAEARHEAARLRQEAQEQGATLIAEMRAEGQRQREEIIAAGHSQIEADRKAAAQALRQDVGQLATTLAGKLVGESLEDHARQSRTIDRFLDDLEEKAEAAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JQB9</accession>
    <name>A0A2M9JQB9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CG723_24385</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000010">
        <property type="protein sequence ID" value="PJN09070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN09070">
        <property type="protein sequence ID" value="PJN09070"/>
        <property type="gene ID" value="CG723_24385"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021373">
        <property type="entry name" value="DUF2993"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11209">
        <property type="entry name" value="LmeA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PJN09070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="242" mass="25143" checksum="D1FE8DEE0961121B" modified="2018-04-25" version="1">MRALRILLIVVVILGGLFVIADRVAVNYAEGEAADRVRTSEGLASTPDVSINGFPFLTQAAGGTLDDVEIGIKDYDAKSGGESIRIADLNAEMHGVRFNSSFSSATADSATGTARISYAELLKAVKKQDAAQVAPGVTARIEGLSYGGGDKVKVKVTVHTPVGTLHPTVLSSVKVTDGKVSARADSLPKAGALDLAEGRIRAVTDFQQAIDDLPAGIELDRVEAVKDGVEISVKGSKLDLVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JQR6</accession>
    <name>A0A2M9JQR6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Ribbon-helix-helix protein, CopG family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CG723_25200</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000010">
        <property type="protein sequence ID" value="PJN09208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN09208">
        <property type="protein sequence ID" value="PJN09208"/>
        <property type="gene ID" value="CG723_25200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010985">
        <property type="entry name" value="Ribbon_hlx_hlx"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47598">
        <property type="entry name" value="SSF47598"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PJN09208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="60" mass="6796" checksum="924622032EC23747" modified="2018-04-25" version="1">MGSTVLSLRIDGELLDRLKSHAAKRGMSVQDYVVRTLIRDDFDERFATSVEETEKFYGAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JRA3</accession>
    <name>A0A2M9JRA3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative baseplate assembly protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_24090</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000009">
        <property type="protein sequence ID" value="PJN09405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN09405">
        <property type="protein sequence ID" value="PJN09405"/>
        <property type="gene ID" value="CG723_24090"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006949">
        <property type="entry name" value="Baseplate_J-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011749">
        <property type="entry name" value="CHP02243"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04865">
        <property type="entry name" value="Baseplate_J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02243">
        <property type="entry name" value="TIGR02243"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Baseplate_J" evidence="2">
        <location>
            <begin position="767"/>
            <end position="927"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="338"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="349"/>
            <end position="364"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN09405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="1066" mass="113413" checksum="203B22E3F0213762" modified="2018-04-25" version="1">MSPSACRCGSCPGTRSTTPARIWNRPALPALQYRAGIYDQFLTSMLAGLSSTDHSSLAGLTTREPDDPSIALMEGWALIADILTFYQERIVNEGYLRTATEQESLVRLGRLVGHRPRPPLAAGTFLAYTLDAGTRCTIPAGSQVKSAPPPGGLPQVFETSEELSARAEWNQLPVRGTVPPSIDPDAAEIMPSLELDGVQPNLGAGDRLLFTFGDPSRNVTRLVESTRLDPYRRRSTVLLKAPGPAHQLKREVQAFREDVDKAVRKPQPSKPFEDFLRVLREVLHAGDILRDPDALAETLDDKLQAFRERLSGAQADAAHAAELLDKVTARVAAVRTAAGAVTGPPTGTAGKRPPSSSDGEPSVNPLSLGRQVLHGLERPPSRPPRNPSEMATPVTELFGPDSDAMSRLLTAKSPHLAETLYRALGTVSVSAADPPGVQCFRVKAAPLGATIPDVASVRRLLRSVDSTDPPGPDESTDDGRVLLLDSVYDTILPGTWIAVRRTDGHTKTRIIQVTDVTQLAVADEHYAARVTRLRLAEPWTDDPGDLSARRATTVWAAGETLALADPPDTSVVAGDAIELAGAYEGLTPGRWLIVSGERTDIPNVSGVQGTELVMLGGVHQGLDDTPFGHGVRSTLALTTELAYRYRRDTVVIHGNVVFATAGETRNEILGSGDATQAGQVFPLRQGPLTWLPARTPDGARETLTVRVSGVEWPRIADLNEADPATLAYRLRVGIDGGTAVEFGDGRHGSRLPTGVENVTAHYRIGGGTPGNVAAGQVNHVVSRPLGVSGVTNPLPATGGTDADGREEARRSIPLRLSALDRLVSVRDYEDFALAFAGIGKAVARRCPVGARQFVHVTVDAADNAPLDARSLLLEALQSALSRYGDPALPVRVEVCERVRLVLSLGVRTLPDHSRDVVEQAVRDALLDRLGFAAAELAQPVFLSAAIAAAQAVPGVDFVDVDAFGGVGDDVDAAGVIRFARELTASPCVPGHPAGYRETLYTPAPEETSASVAAANGLTEEQLALLNPDGVPRTPGTAMVVRRALRPAQLVLLDPSLPETLVLRRIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JRC9</accession>
    <name>A0A2M9JRC9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">AAA family ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_24130</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000009">
        <property type="protein sequence ID" value="PJN09413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN09413">
        <property type="protein sequence ID" value="PJN09413"/>
        <property type="gene ID" value="CG723_24130"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA" evidence="2">
        <location>
            <begin position="467"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN09413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="688" mass="74457" checksum="D57770AB32F8DF2B" modified="2018-04-25" version="1">MTTASASGPETPAGPLWAPNSKSTQDREDSWQADNSRFLSAALEWLRLALRAHIETRSGPPVTTVTEEELKAAEKDMEHAAEAQPPPALISLGGLLGLSSFELHTLLLCVAQELDPSVADLCAQAQGRPLASGPTFALALSLFPDPAWDVMSPYRGLRFWQLVEINRTAEQPLVTSPLRADERIVNHVKGLDYLDDRLEPFLTAVESHAAPTDLAPSHHSAEEEITECWRHTPSWAGGRLPVIQLLGADRESKQSVAAQSAAQLGLLLYRLPAGLLPEPTAELESIARLWQREALLLPFALYLDADDTELVGGADGAGDRLVGRFLQRSGGPCFVATRELRPDVPAPTSGVDIAPPPVAERASIWRTAFPPKDADRLAGQFALGLSAIQEIATASGSDPDIAWRTCLARTRPRLGALAQRLEPKATWDDIVLPAQEAALLRQIGDQVAQRCTVYQNWGFAETHNRGLGISALFTGPSGTGKTMAAEVLAGHLSLDLYRVDLSAAVSKYIGETEKNLRRLFDAAEPGGAILFFDEADALFGKRSQVKDSHDRYANIEVSYLLQRMEAYQGLAILATNLRRSLDTAFLRRLRFIVPFAFPDTTQRREMWARVFPGSAPVDALDLDHLAGLPLSGGMIRNIALNAAFAAAAEGTTIGMAAVLTAARTELRKVEMPLSEGDFVWDGSTGVTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JRN5</accession>
    <name>A0A2M9JRN5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">TetR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CG723_22585</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000008">
        <property type="protein sequence ID" value="PJN09533.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN09533">
        <property type="protein sequence ID" value="PJN09533"/>
        <property type="gene ID" value="CG723_22585"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="3">
        <location>
            <begin position="22"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="45"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PJN09533.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="227" mass="24443" checksum="2863B952261E73FE" modified="2018-04-25" version="1">MSPPTTRKVGRPRAQERPASGLEPREEVLAAAAELFTTHGYTATSTRAVAERAGLRQASLYHYFDGKEAILAALLEGTVRPSLEIARDLVARTGTAAEARLWALCHSDVTLLCRGPHNLGALYLQPEVQTERFGVFHQVRTELKASYGELLSGTEPGAALGVEELALRTDLLFGLTESVILIRRADPARDASALAVATADAALRIAGVPQRSLARLRREGQQLLAAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JRW2</accession>
    <name>A0A2M9JRW2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">SpdA protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_21935</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000008">
        <property type="protein sequence ID" value="PJN09621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN09621">
        <property type="protein sequence ID" value="PJN09621"/>
        <property type="gene ID" value="CG723_21935"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021235">
        <property type="entry name" value="DUF2637"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10935">
        <property type="entry name" value="DUF2637"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="66"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="95"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="122"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="134"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="158"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN09621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="225" mass="23611" checksum="9E79C3AF52E14266" modified="2018-04-25" version="1">MNRSIRLDAVLVQAVIAGALSFSHLHDLAEAAGQTGWKAWAYPISVDLLLVAAWRRLRTARGDRAAWAWFAIALIASLGANIATAGLLDLANAPAWLRIVVAGWPALAFLGGTLLVHTPAEATPAPETETTADPPAVDLHRTDAPELDSAPEQPEPAAELPAVEPAPEPKPVPASIPPALLDHARKLADHHRATTGTPLPIDNLRAQLGLPATVVDSIAAHLQLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JSG1</accession>
    <name>A0A2M9JSG1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Peptide ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CG723_21605</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000007">
        <property type="protein sequence ID" value="PJN09793.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN09793">
        <property type="protein sequence ID" value="PJN09793"/>
        <property type="gene ID" value="CG723_21605"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015833">
        <property type="term" value="P:peptide transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013563">
        <property type="entry name" value="Oligopep_ABC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08352">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="5"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="39"/>
            <end position="46"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PJN09793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="254" mass="27361" checksum="26A015C98501E8DC" modified="2018-04-25" version="1">MTAVLELDSVGHTYRGAAAPVVEDVSLTVDAGHSLALVGESGAGKTTLLRLLLGLARPTTGTVRFDGDPLRLGDRAQMRRFRRSVQCVFQDPYASLDPRQRVSRIVAEPLRSLGVATGAAAHAKVAEALEQVGLPADAASRYPHEFSGGQRQRIAIARATVCDPRVLLADEPVSALDVTTRVKVVDLLGELKRERGLTIVMVSHDLSVVAALCERTAVLERGRVVEQGQTRDVLGSPEHPYTRRLLDSVPRLPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JSI7</accession>
    <name>A0A2M9JSI7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CG723_21735</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000007">
        <property type="protein sequence ID" value="PJN09818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN09818">
        <property type="protein sequence ID" value="PJN09818"/>
        <property type="gene ID" value="CG723_21735"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PJN09818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="83" mass="8575" checksum="8D420B11766C5E20" modified="2018-04-25" version="1">MVEILKPVKKVDLGDAADLSTKMGNDDVAASLVTFCATWESGGAFLADCAATLADGLEAANGHYEDTDEAIRDAVKSVKTALA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JSJ5</accession>
    <name>A0A2M9JSJ5_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Ribonuclease J</fullName>
            <shortName evidence="9">RNase J</shortName>
            <ecNumber evidence="9">3.1.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">rnj</name>
        <name evidence="12" type="ORF">CG723_21900</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">CB01635</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and/or decay.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Homodimer, may be a subunit of the RNA degradosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the metallo-beta-lactamase superfamily. RNA-metabolizing metallo-beta-lactamase-like family. Bacterial RNase J subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="9"/>
    <dbReference type="EMBL" id="NNBL01000007">
        <property type="protein sequence ID" value="PJN09845.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN09845">
        <property type="protein sequence ID" value="PJN09845"/>
        <property type="gene ID" value="CG723_21900"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004534">
        <property type="term" value="F:5'-3' exoribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004521">
        <property type="term" value="F:endoribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10710">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01491">
        <property type="entry name" value="RNase_J_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011108">
        <property type="entry name" value="RMMBL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004613">
        <property type="entry name" value="RNase_J"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042173">
        <property type="entry name" value="RNase_J_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030854">
        <property type="entry name" value="RNase_J_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041636">
        <property type="entry name" value="RNase_J_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07521">
        <property type="entry name" value="RMMBL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17770">
        <property type="entry name" value="RNase_J_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004803">
        <property type="entry name" value="RnjA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00649">
        <property type="entry name" value="MG423"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 9" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="7 9" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="5 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 9" id="KW-0540">Nuclease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="9" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Lactamase_B" evidence="11">
        <location>
            <begin position="31"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="9 10">
        <location>
            <begin position="373"/>
            <end position="377"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR004803-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PJN09845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="561" mass="61051" checksum="E3FDCC9F8F90B553" modified="2018-04-25" version="1">MSHPHPELGAPPKLPKGGLRVTPLGGLGEIGRNMTVFEYDGRLLIVDCGVLFPEEEQPGIDLILPDFTSIRDRLDDIDGIVLTHGHEDHIGGVPYLLREKPDIPLIGSKLTLALIEAKLQEHRIRPYTLEVAEGDRERLGPFDCQFVAVNHSIPDALAVAIRTPAGMVVHTGDFKMDQLPLDRRLTDLPTFAKLGEEGIDLLLTDSTNAEVPGFVPPERDISNVIRGVFAGAQKRIIVASFASHVHRIQQILDAAHEYGRRVAFVGRSMVRNMGIARDLGYLKVPPGLVVDVKTLDDLPDNEIVLVCTGSQGEPMAALSRMANRDHQIRIVSGDTVILASSLIPGNENAVYRVINGLTRWGANVIHKGNAKVHVSGHASAGELLYFYNICKPKNLMPVHGEWRHLRANAELGALTGVPHDRIVIAEDGVVVDLVEGKARIVGKVQAGYVYVDGLSVGDVGEPALKDRKILGDEGIISVFVVVDSSTGKITSGPTIQARGSGIDDSAFSAVMPRIQEVLDKSAQDGVVEPHQLQQLIRRTLGKWVSDTYRRRPMILPVVVEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JSX5</accession>
    <name>A0A2M9JSX5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Methylmalonyl-CoA mutase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CG723_19835</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CB01635</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>adenosylcob(III)alamin</name>
            <dbReference type="ChEBI" id="CHEBI:18408"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000006">
        <property type="protein sequence ID" value="PJN09979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN09979">
        <property type="protein sequence ID" value="PJN09979"/>
        <property type="gene ID" value="CG723_19835"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031419">
        <property type="term" value="F:cobalamin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006159">
        <property type="entry name" value="Acid_CoA_mut_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006158">
        <property type="entry name" value="Cobalamin-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036724">
        <property type="entry name" value="Cobalamin-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02310">
        <property type="entry name" value="B12-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52242">
        <property type="entry name" value="SSF52242"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00640">
        <property type="entry name" value="acid_CoA_mut_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51332">
        <property type="entry name" value="B12_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="B12-binding" evidence="3">
        <location>
            <begin position="7"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PJN09979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="138" mass="14314" checksum="86A4233C6F73F5BD" modified="2018-04-25" version="1">MGVAAGPIRVVVAKPGLDGHDRGAKVIARALRDAGMEVIYTGLHQTPEQIVDTAIQEDADAIGLSILSGAHNTLFARVIELLVERDAADIKVFGGGIIPEADIAPLKEKGVAEIFTPGATTASIVDWVNANVRQPAGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JTG1</accession>
    <name>A0A2M9JTG1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ribosomal-protein-alanine N-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">rimI</name>
        <name evidence="2" type="ORF">CG723_20090</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000006">
        <property type="protein sequence ID" value="PJN10153.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN10153">
        <property type="protein sequence ID" value="PJN10153"/>
        <property type="gene ID" value="CG723_20090"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006474">
        <property type="term" value="P:N-terminal protein amino acid acetylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006464">
        <property type="entry name" value="AcTrfase_RimI/Ard1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01575">
        <property type="entry name" value="rimI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN10153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="167" mass="18396" checksum="DD16546ADE1DEF97" modified="2018-04-25" version="1">MRWWDIESVHALEKDLFPDDAWSRGMFWSELAHARGAGSTRRYVVAHDGDRLVGYAGLAASGTDYEGGSGVGADVQTIAVARDQWGTGLGARLLTVLLRHATDFECSEVTLEVRVDNTRAQKLYQRFGFEPIGFRRGYYQPGNVDALVMRLTDPSTSVTPVQGTENG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-05-25" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JTG3</accession>
    <name>A0A2M9JTG3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">D-threo-aldose 1-dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_17365</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000005">
        <property type="protein sequence ID" value="PJN10176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN10176">
        <property type="protein sequence ID" value="PJN10176"/>
        <property type="gene ID" value="CG723_17365"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NADP_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42686">
        <property type="entry name" value="PTHR42686"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="SSF51430"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldo_ket_red" evidence="1">
        <location>
            <begin position="11"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN10176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="336" mass="36339" checksum="DBD4F671D15CE2AA" modified="2018-04-25" version="1">MGIKSLLPGSLGFGTAPLGNMFRSIPDEEAAATVEAAWDQGIRYFDTAPFYGAGLSELRLGEVLAGRPRDEYVLSTKVGRVILDELEDPADRDLGEKGGLFEHGRANKMVDLYTADATLRSIEDSLERLKTDRLDIVWVHDVAQDFHGDDWLAVYETARTGAFRVLQNLRDEGVIKAWGLGVNRVEPIELTLDLDEPKPDAFLLAGRYTLLDHNRSLQRLLPAATEQNVDMVVGGPYSSGILAGGQHFEYQKAPADIIAKVERIKALAAAHGVSIKAAALQFALAHPATAAVVPGATRPSRIAEDVAALNENVPAAFWTALRDEHLIAADAPTPTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JTH8</accession>
    <name>A0A2M9JTH8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glyoxalase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_17475</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000005">
        <property type="protein sequence ID" value="PJN10190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN10190">
        <property type="protein sequence ID" value="PJN10190"/>
        <property type="gene ID" value="CG723_17475"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041581">
        <property type="entry name" value="Glyoxalase_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18029">
        <property type="entry name" value="Glyoxalase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VOC" evidence="1">
        <location>
            <begin position="3"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN10190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="122" mass="13471" checksum="2245F7344F03ABF4" modified="2018-04-25" version="1">MLRIGSVVLGVSDVPRAAAFWTEALGYVPREAMEDDWVVLVPAKGAGVQLSLGLSETPVQERPRIHLDLYARDAPDQAAEVERLVSLGAQRVDWDLYPDDADFIVLADPDGNRFCVIDTRHN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JTI3</accession>
    <name>A0A2M9JTI3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CG723_19425</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000006">
        <property type="protein sequence ID" value="PJN10132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN10132">
        <property type="protein sequence ID" value="PJN10132"/>
        <property type="gene ID" value="CG723_19425"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PJN10132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="136" mass="14724" checksum="A21462B7899718BD" modified="2018-04-25" version="1">MRRHAAGFVAHATARNRLPLDYTVASLRVADFLVDGLRKGTSDRASVAGALFGIGAYVGEVLVRRAGAVWVDFDAAQRAYFGQPAGVRMPDGRMWNPLGKVVNRFELGREESLQTFYLTLHGRGGDRGTGKTCAAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JTP0</accession>
    <name>A0A2M9JTP0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Isochorismatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_17820</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000005">
        <property type="protein sequence ID" value="PJN10250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN10250">
        <property type="protein sequence ID" value="PJN10250"/>
        <property type="gene ID" value="CG723_17820"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.850">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000868">
        <property type="entry name" value="Isochorismatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036380">
        <property type="entry name" value="Isochorismatase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00857">
        <property type="entry name" value="Isochorismatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52499">
        <property type="entry name" value="SSF52499"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Isochorismatase" evidence="1">
        <location>
            <begin position="6"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN10250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="188" mass="19919" checksum="4287A0B9CC4ECF64" modified="2018-04-25" version="1">MAKANSALLVMDVQRDVVRIADDGSGYLARLKGAIAGARAAGVPVIYVVMRLRPGQPEVGPRNRTLATVLQAGLFTDGAPGTEIHDDVAPRPGDIVVTKRRASAFSGSDLDLVLRARDINSLVLAGIATSGVVLHTLCQANDLDFGLTVLSDACLDLDPEVHRTLIGNLFPQWAEVVTVEDWVGSLAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JTP2</accession>
    <name>A0A2M9JTP2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">TetR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CG723_17845</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000005">
        <property type="protein sequence ID" value="PJN10255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN10255">
        <property type="protein sequence ID" value="PJN10255"/>
        <property type="gene ID" value="CG723_17845"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039538">
        <property type="entry name" value="BetI_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13977">
        <property type="entry name" value="TetR_C_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0678">Repressor</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="3">
        <location>
            <begin position="2"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="2">
        <location>
            <begin position="25"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PJN10255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="194" mass="21087" checksum="108C150E4A59BB45" modified="2018-04-25" version="1">MSTRRAKLLEATCRVIALRGVRGLRVEEVAAEAGVSKTLIYYHFRDRSGLVTSALEYVNDRAEGYAGVSDDDDAPVRDVLLRLLVGEFQDDRSVRENSAVWGEVRAAATFDDGLRPVLATLTERWLVELAEVIEDGQDEGDIPASVDSRAAAVRLTSLVEGLSGRWLAGLLTTAEARAHVAAALERELLPDPQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JTP5</accession>
    <name>A0A2M9JTP5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_20355</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000006">
        <property type="protein sequence ID" value="PJN10157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN10157">
        <property type="protein sequence ID" value="PJN10157"/>
        <property type="gene ID" value="CG723_20355"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="63"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN10157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="89" mass="9740" checksum="1AE66094F16806ED" modified="2018-04-25" version="1">MPVVLAIFSLVGLVCLWCGVNWAFDVRGITTRRSERIRQRNAHMLGMPGALDAPTTVFGSVGYLRFLGALMAFAGLVLFVVAYALWHLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JTR1</accession>
    <name>A0A2M9JTR1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">D-alanyl-D-alanine carboxypeptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CG723_17950</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000005">
        <property type="protein sequence ID" value="PJN10275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN10275">
        <property type="protein sequence ID" value="PJN10275"/>
        <property type="gene ID" value="CG723_17950"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009002">
        <property type="term" value="F:serine-type D-Ala-D-Ala carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001967">
        <property type="entry name" value="Peptidase_S11_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00768">
        <property type="entry name" value="Peptidase_S11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0645">Protease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014754218" evidence="3">
        <location>
            <begin position="23"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="357"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_S11" evidence="4">
        <location>
            <begin position="52"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="315"/>
            <end position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PJN10275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="385" mass="39892" checksum="E916F925FACAA951" modified="2018-04-25" version="1">MARFVGFYPCITKSVVASVACAAIVVGPVGGVATAVPRSDGVSSQIQTAPGTPDAPELSALSWTVTDVGTGKLLAAKAPHLRLPPASTLKTLFALALLPKLPAATEHTAVTADIADVAPGSSLVGVHEGTSYTVGDLWRGVFLSSGNDAVHTLARLNGGLDLTLAQMQATANRLGAHDTSVRTPDGFDTPGQYSSAYDLSLFAKAGLQNPDFRRYCSTKSAQFPAVGGPDSFGIQNTNRLLVGSHGVEPYPGLIGVKNGYTSEAGNTLVAAATQDNRTILVTVMNPQDTSSNAVYEESRELLDWGFEAAPGAVRASLERGPASHTPSHRPEPAHHGAVAAQASTTSKAASSGLTRHLGAAVALLGLACVPFVLKAVRRRRRRSTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-06-02" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JU62</accession>
    <name>A0A2M9JU62_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_18820</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000005">
        <property type="protein sequence ID" value="PJN10414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN10414">
        <property type="protein sequence ID" value="PJN10414"/>
        <property type="gene ID" value="CG723_18820"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="2">
        <location>
            <begin position="49"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN10414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="195" mass="21631" checksum="9F194D12C476853D" modified="2018-04-25" version="1">MGKAGPHAPYRHTKGEKSVDTSQARHTDGDLTVRKGGAEFIDRLAPLWLALHAHHQSVQPGFPYFPDEDSWELRRGCYRRWILDEGSFVLLAERDGQPVGYAFVQIEEGPDDTWVTGTRIAELQTLSVLPAERGHGIGTLLLDLVDAELDRIGVTDLLIGTLAANTGAQRLYERRGLRPVLVYYARFAADDAKPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JU74</accession>
    <name>A0A2M9JU74_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alpha/beta hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_18855</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000005">
        <property type="protein sequence ID" value="PJN10419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN10419">
        <property type="protein sequence ID" value="PJN10419"/>
        <property type="gene ID" value="CG723_18855"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="5"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN10419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="229" mass="25019" checksum="61C16EA7FC33E1F5" modified="2018-04-25" version="1">MTTYVLIPGAGGSAWYWHGVGDELMRRGRDVVSVDLPGDDTRAGLPEYVDRVVDAVGDRTDLVVVGQSLGGFTAPLVCPRLPVSLLVLVNGMIPRPGETPGEWWAHTGQEEARRANDVREGRDPDAETDLETYFLHDLPQTLIDASAEHNQDESAAAFATPFTLDVWPAVETRVVTGRDDRFFPADFQRRVAEDRLGITPDEVPGGHLAALSHPMELADCLEAYVKESA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JUD8</accession>
    <name>A0A2M9JUD8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Bacteriocin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CG723_18995</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CB01635</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Encapsulin nanocompartment</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the encapsulin family. Family 1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000005">
        <property type="protein sequence ID" value="PJN10442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN10442">
        <property type="protein sequence ID" value="PJN10442"/>
        <property type="gene ID" value="CG723_18995"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007544">
        <property type="entry name" value="Linocin_M18"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04454">
        <property type="entry name" value="Linocin_M18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF019254">
        <property type="entry name" value="CFP29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1284">Encapsulin nanocompartment</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00033738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00033743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00033787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PJN10442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="265" mass="28657" checksum="73D712F993F83C1D" modified="2018-04-25" version="1">MNNLHRELAPISEAAWAEIEQEAGRTFQRHVAGRRVLDVTGPDGLELAAVGTGHLRSVTPPAPGVMARLREAQPLVELRVPFTVSREAVDDVARGSNDSDWQPVKDAARTMAFAEDQAIFDGYAAARIEGVRERTSNPVLSLPAEPRDYPDTIARALSSLRLAGVDGPYSLLLGAEAYTAVSETTDHGFPVSGHIARLLDGDLIWAPAINGAFVLTTRGGDYELRIGQDLSIGYTSHDATGVELYFQETLTFLMYTDEAVVALRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JUF1</accession>
    <name>A0A2M9JUF1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CG723_18785</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000005">
        <property type="protein sequence ID" value="PJN10407.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN10407">
        <property type="protein sequence ID" value="PJN10407"/>
        <property type="gene ID" value="CG723_18785"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PJN10407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="262" mass="27638" checksum="8348C9370A9B0E5C" modified="2018-04-25" version="1">MLRLVDACSGLPVAPVMHRSVVRIGVPVTLPEGGEALSDVRAMLVADVLTRVLELSGTIAYTGLICPDGADERRAALQARAADLGIHPAAAHGDERGVEGELGGPFAVRVGPNEDAPDEANGDVIRLAVGDAHAADGVADRADDPLALRLALLTEPRTEPLRLAPASVSAAHHTLLRWRHAVATWADSPSRPMPGPARDSMRDCLEDDLDLPGVLRTLHRLEHSGDAPAGALFETFAYVDRVLGLDLVRDVGRGPAPPRLLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JUT0</accession>
    <name>A0A2M9JUT0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CG723_15560</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000004">
        <property type="protein sequence ID" value="PJN10629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN10629">
        <property type="protein sequence ID" value="PJN10629"/>
        <property type="gene ID" value="CG723_15560"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PJN10629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="120" mass="13008" checksum="CA9EFB58C935102C" modified="2018-04-25" version="1">MFGPRGDLLVDAFVDRWGVVPSADSKFTWCELATGLSTPNGHAGGLRAARAESLITLHGEAGAPREARRTHLSIALAEESAIDVITDLLHWLRAHGRDPDEALNRAKGHFEAEVRARESS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JVG2</accession>
    <name>A0A2M9JVG2_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Heat-inducible transcription repressor HrcA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">hrcA</name>
        <name evidence="8" type="ORF">CG723_17060</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CB01635</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Negative regulator of class I heat shock genes (grpE-dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the HrcA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000004">
        <property type="protein sequence ID" value="PJN10875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN10875">
        <property type="protein sequence ID" value="PJN10875"/>
        <property type="gene ID" value="CG723_17060"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00081">
        <property type="entry name" value="HrcA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001034">
        <property type="entry name" value="DeoR_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002571">
        <property type="entry name" value="HrcA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021153">
        <property type="entry name" value="HrcA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023120">
        <property type="entry name" value="WHTH_transcript_rep_HrcA_IDD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34824">
        <property type="entry name" value="PTHR34824"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01628">
        <property type="entry name" value="HrcA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08220">
        <property type="entry name" value="HTH_DeoR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005485">
        <property type="entry name" value="HrcA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00331">
        <property type="entry name" value="hrcA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 5" id="KW-0678">Repressor</keyword>
    <keyword evidence="3 5" id="KW-0346">Stress response</keyword>
    <keyword evidence="4 5" id="KW-0804">Transcription</keyword>
    <keyword evidence="2 5" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH deoR-type" evidence="7">
        <location>
            <begin position="34"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="domain" description="HrcA" evidence="6">
        <location>
            <begin position="103"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01628"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF08220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PJN10875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="338" mass="36639" checksum="1CAE7B480FB451B4" modified="2018-04-25" version="1">MLSERRLEVLRAIVQDYVGTEEPVGSKALTERHSLGVSPATVRNDMAALEEEGFIAQPHTSAGRIPTDKGYRLFVDKLTAVKPMTGPERRAIQNFLDGAVDLDDVVGRTVRLLAQLTRQVAVVQYPSLTRSTVRHVELLSLAAARLMLVLITDTGRVEQRMIDCPAPFGETSLADLRARLNSRVAGRRFADVPQLVQDLPESFDAEDRGTVSTVLSTLLETLVEETEERLMIGGTANLTRFGHDFPLTIRPVLEALEEQVVLLKLLGEVNDSGMAVRIGHENAHEGLSSTSVVSVGYGSGSEAVAKLGVVGPTRMDYPGTMGAVRAVARYVGQILAES</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JVY1</accession>
    <name>A0A2M9JVY1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CG723_08555</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN11030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN11030">
        <property type="protein sequence ID" value="PJN11030"/>
        <property type="gene ID" value="CG723_08555"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PJN11030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="146" mass="16199" checksum="7CDD47F446FA8463" modified="2018-04-25" version="1">MGLVSRQQMDADVDFYALWLEDADDTSERDEPEDGAPFVAACGQRVYLQSGGHTHTPALSVEVWEDQPPVDGGVWEAQGEAGMDVPSGQVGVWTYGGPCEGAIELGEVGRRWHVRVYVSGRERVRELAEQEVPVHAERYLLQFWPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-05-25" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JWM8</accession>
    <name>A0A2M9JWM8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ABC transporter substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_10225</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN11300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN11300">
        <property type="protein sequence ID" value="PJN11300"/>
        <property type="gene ID" value="CG723_10225"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025997">
        <property type="entry name" value="SBP_2_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13407">
        <property type="entry name" value="Peripla_BP_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014805979" evidence="1">
        <location>
            <begin position="33"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="domain" description="Peripla_BP_4" evidence="2">
        <location>
            <begin position="52"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN11300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="358" mass="37940" checksum="6650F6D62DBB3192" modified="2018-04-25" version="1">MAGRTVRKRNRSRIVGAAAVAACAALVLTACGSTKDDVASGGKGGGDGKGKVGVILPLLTSPFWQSYNDYVPKMAKSESVDALKTVNSNSDPSQQITDINNQLNQGVKGLVVAPLDSAAISAGLDQAERKGVPVVAVDVAPEKGKVAMVVRANNVAYGEKACEYLGQQVKTGKVVQIMGDLASVNGRERSQAFRDCVKKKYPDLKVLEIPAKWESDTAASKLDTLLNANPDIKGIYMQAGGVYLAPTLQTLKSKGLLKKTGEKGHITIVSNDGIPQEFAAIRKGQIDATVSQPADAYAKYGMYYIKAAMQGKTFKPGPTDHDSEIVKLPSGILEDQLPAPLVTKDNVDDPKLWGNTVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JX08</accession>
    <name>A0A2M9JX08_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Long-chain fatty acid--CoA ligase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CG723_10555</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN11358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN11358">
        <property type="protein sequence ID" value="PJN11358"/>
        <property type="gene ID" value="CG723_10555"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0436">Ligase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014741147" evidence="1">
        <location>
            <begin position="25"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding" evidence="2">
        <location>
            <begin position="36"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding_C" evidence="3">
        <location>
            <begin position="445"/>
            <end position="521"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PJN11358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="536" mass="57713" checksum="E344275A368223DD" modified="2018-04-25" version="1">MLTVRSCPANSRRSRRRWRTPAWARSCPTPYDSTPRCTPGAPAVTEGSRTLTYAELDRRGNRVGQALLAAGLPKGAHVGYLVRPGVLSAELLMGCAKAGLVATPLNWRLAERELVAVAQDAELAVVLTQTEFLPGARAVRAALPGITLVTESEADAGEHTYEKWLAAAGDVDPGAGSEDAVFLQLYTSGTTGLPKGVQLTLNNCSASEAQLCEMGWTTASVSLNVMPVFHIAGTGWLVNALAAGAHTVLVPDLVPAAVVDLMERHRVTHTFFVPAILHLLTALPDIDERDFSALQLIVYGASPITPALLRRSMEAFGCGFYQKYGLTETTGSAARLLPEDHVVDGPRSALLRSAGNVWPEVEVAIADPVTGDHVAPGVVGEILTRSRQVTPGYWKRPRENEALFTADGWLRTGDAGYLDKDGYLFVTDRMKDMVITGGENVYPIEVESLLAEHPAVLDVAVFGTPDELWGEAVTAAVVLRPGTDAVTAQDLIDFARERIASYKKPRIVHFVGELPRNPSGKILKRVLRQNLAPREP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JXF7</accession>
    <name>A0A2M9JXF7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_11770</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN11566.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN11566">
        <property type="protein sequence ID" value="PJN11566"/>
        <property type="gene ID" value="CG723_11770"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014676900" evidence="1">
        <location>
            <begin position="29"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN11566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="130" mass="13789" checksum="B54945291CDF88B8" modified="2018-04-25" version="1">MRRSTTLLTTALAGVAAALTLAAPTAVATAPAGSVRAAGPGQVCFWTEAGQHGQAWCYAPPGYAEAENGTQRHAYSFDSRVDGTVYAISYGPGNSCLYREIRKDDYDENWEAWATKFDGVSDNKMGCEAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JXH5</accession>
    <name>A0A2M9JXH5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_11895</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN11585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN11585">
        <property type="protein sequence ID" value="PJN11585"/>
        <property type="gene ID" value="CG723_11895"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="8"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="31"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN11585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="199" mass="22519" checksum="549FCC5DE89E5928" modified="2018-04-25" version="1">MGRRKDQEARRAQLHQATLRALHSRGLEGLRLRDVAEEAGVTSAAVLYYYDDLDELMYETFQRAIERFSREREESAEKFPDARDRLRACVEHGVADGPDDLLPRLLFEYWPRSLRDPRAATLDATLTERQIAVYYATLVLGEAQGHFVLVEPAGQLAAGFVAMEDGFQMEVLAGRRTRTEVIAMLHGYARMATGFDPSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JXI6</accession>
    <name>A0A2M9JXI6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Serine protease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CG723_11960</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CB01635</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN11596.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN11596">
        <property type="protein sequence ID" value="PJN11596"/>
        <property type="gene ID" value="CG723_11960"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004236">
        <property type="entry name" value="Pept_S1_alpha_lytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001316">
        <property type="entry name" value="Pept_S1A_streptogrisin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018114">
        <property type="entry name" value="TRYPSIN_HIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033116">
        <property type="entry name" value="TRYPSIN_SER"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02983">
        <property type="entry name" value="Pro_Al_protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00861">
        <property type="entry name" value="ALYTICPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="SSF50494"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00134">
        <property type="entry name" value="TRYPSIN_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00135">
        <property type="entry name" value="TRYPSIN_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 10" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014812522" evidence="7">
        <location>
            <begin position="33"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="440"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="domain" description="Pro_Al_protease" evidence="9">
        <location>
            <begin position="93"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S1" evidence="8">
        <location>
            <begin position="189"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="355"/>
            <end position="426"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PJN11596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="474" mass="46901" checksum="0E1369E4DEBB95E7" modified="2018-04-25" version="1">MRHARRTARRITRLAAVGGLLCGSLLVTHAIASEPGTSGPPVPVGERLVTQLGTARTAGSWLGADGRTVIAVTDAGAAADVRRAGARAEVVRHSMRDLRSAAATLRAAPRVAGTAWAMDYGSNEVVVRADSTVSAADWSRLADVAKAIGASVRMERTRGTFTTRVDGASPIFASGGRCSAGFDVTDGSDAFLLTAGHCGPVGTTWFARPGDATALGTTVSGTFPGNDFSLVRYDDGVPHAESDVVAIGGGRGVRITGATDPVVGQRVFRSGSTTGLHSGRVTALNATVNYPEGTVTGLIQTTVCAEPGDSGGPLFADGLALGLTSGGNGNCDAGGTTFFQPVGAAMTALDVRLAGASGDDGSEAGSGQARPGGDGSAPSTPPAGSEAGARGGGGTGTGTGPGTNMGGAAETGDGTVSGTGTSTDTGPVAAISRVVNTRSVGPGLLVIGGSLIALVAVRSMRSSRLSRRGRGAWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JXN9</accession>
    <name>A0A2M9JXN9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">thiD</name>
        <name evidence="7" type="ORF">CG723_12220</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CB01635</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the phosphorylation of hydroxymethylpyrimidine phosphate (HMP-P) to HMP-PP, and of HMP to HMP-P.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>4-amino-2-methyl-5-(phosphooxymethyl)pyrimidine + ATP = 4-amino-2-methyl-5-(diphosphooxymethyl)pyrimidine + ADP</text>
            <dbReference type="Rhea" id="RHEA:19893"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57841"/>
            <dbReference type="ChEBI" id="CHEBI:58354"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.7"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>4-amino-5-hydroxymethyl-2-methylpyrimidine + ATP = 4-amino-2-methyl-5-(phosphooxymethyl)pyrimidine + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23096"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16892"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58354"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.49"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Cofactor biosynthesis; thiamine diphosphate biosynthesis; 4-amino-2-methyl-5-diphosphomethylpyrimidine from 5-amino-1-(5-phospho-D-ribosyl)imidazole: step 3/3.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN11639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN11639">
        <property type="protein sequence ID" value="PJN11639"/>
        <property type="gene ID" value="CG723_12220"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00060">
        <property type="reaction ID" value="UER00138"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008902">
        <property type="term" value="F:hydroxymethylpyrimidine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008972">
        <property type="term" value="F:phosphomethylpyrimidine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009228">
        <property type="term" value="P:thiamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009229">
        <property type="term" value="P:thiamine diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01169">
        <property type="entry name" value="HMPP_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045029">
        <property type="entry name" value="HMP/HMP-P_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004399">
        <property type="entry name" value="HMP/HMP-P_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013749">
        <property type="entry name" value="PM/HMP-P_kinase-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20858">
        <property type="entry name" value="PTHR20858"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08543">
        <property type="entry name" value="Phos_pyr_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="SSF53613"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00097">
        <property type="entry name" value="HMP-P_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0784">Thiamine biosynthesis</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Phos_pyr_kin" evidence="6">
        <location>
            <begin position="22"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00000565"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00003848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PJN11639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="281" mass="28631" checksum="E8CA01280FE9838C" modified="2018-04-25" version="1">MTVPASGGRVAPPRVLTVAGSDSGGGAGIQADLKTMLALGAHGMSVLTAVTAQNSLGVQGAWELPVDAVRMQYRSVVDDIGVQAVKTGMLSSPVLVEAVAELLAGTDAPVVVDPVSVSKHGDPLLAEDALDAVRTKLLPVATVATPNLDEVAQLTGLAVTDDDGMRRAAARLLSFGPRWVVVKGGHLPGAAVDLLTDGTEEHWLRAPRHDNRHTHGTGCTLASAVAVGLAHGLPVPESVRLAKEYVTGAIAAGFALGSGIGPVDHGWRLPGDRSMGAGKTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JXY5</accession>
    <name>A0A2M9JXY5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_12865</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN11743.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN11743">
        <property type="protein sequence ID" value="PJN11743"/>
        <property type="gene ID" value="CG723_12865"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014657310" evidence="2">
        <location>
            <begin position="19"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="15"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="43"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN11743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="170" mass="18273" checksum="7DF6FD2E97C92FD9" modified="2018-04-25" version="1">MAGVLASVSAVALGTASAASQGSEEPTTAAVQAAPAADSAREHWRPPTVRSDGPEDPHPGKINTDYLISEVSPAQFRGYWYQSHVKGVSVTWVAPSGRDPYNGWDWIEIQDSNGKRVTWDWACGNANCGAYGSTLIDANLTKGAEYKALYYSDGGRVTRGTLQAEFEFWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JYS1</accession>
    <name>A0A2M9JYS1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CG723_14520</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN12019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN12019">
        <property type="protein sequence ID" value="PJN12019"/>
        <property type="gene ID" value="CG723_14520"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015833">
        <property type="term" value="P:peptide transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013563">
        <property type="entry name" value="Oligopep_ABC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08352">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01727">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="6">
        <location>
            <begin position="3"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="292"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="37"/>
            <end position="44"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PJN12019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="329" mass="35060" checksum="EEE280A8300F3440" modified="2018-04-25" version="1">MLLDIDNLTLQLPGTARSVLSSVSLQVASGEVVGLVGESGSGKSTTAKAALRALPDGTAISGSVRVDGTDVLALTGDDLRRHRSRTVAMVHQDPRSALNPVRRIGDFLVERLTGTGLDKKTARTRAVELLDTVGLSDPERRARQRPHELSGGMLQRVVIAGALAAEPRLLLADEATSALDVTTQAEILSLLRTLRADRSLGLLFITHDLHLAAAYCDRVYVMYAGRVVEQQPATQLFDRPQHPYTKGLLACSPTLGEGRRELRPIPGRPPSLADTFGGCEFADRCADAEPACSTWTPEPSPLSGGGSATCRRLPELTGPGPAPLKRSVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JYS9</accession>
    <name>A0A2M9JYS9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">LacI family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CG723_14575</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN12029.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN12029">
        <property type="protein sequence ID" value="PJN12029"/>
        <property type="gene ID" value="CG723_14575"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01392">
        <property type="entry name" value="HTH_LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000843">
        <property type="entry name" value="HTH_LacI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001761">
        <property type="entry name" value="Peripla_BP/Lac1_sug-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00356">
        <property type="entry name" value="LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00532">
        <property type="entry name" value="Peripla_BP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00354">
        <property type="entry name" value="HTH_LACI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50932">
        <property type="entry name" value="HTH_LACI_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH lacI-type" evidence="4">
        <location>
            <begin position="12"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PJN12029.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="341" mass="36069" checksum="249DF45F0F2388D2" modified="2018-04-25" version="1">MPDTRGAKDPQPTLRDVAQRAHVSAMTVSRVLRDDPKVLPDTAERVRAAVAELGYHRNEMARSLRLGSGTGLVGLVVTNLANPFYSRLALGVDAVVAEHGLKTVIGNTGHDLDSERGLVADLVARRVDGIIVVPADDDQRHLAAAADNGVPVVVASRPPNGFTADCVLVDDYGGSRTATRQLLDAGHHRIGFLGPPPAVYTGAERLRGFTDALVDAGIKREPGYVRLGQQQTAEASRAAAELLALPEPPTALFCSNNRNTIGAFRAIRAAGTTTALAGFDDFELADALGLPLIIVAYDSDELGREAGRLLVARLGEARSRDTARRVVVPTTLVHHGTPGKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JYW5</accession>
    <name>A0A2M9JYW5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Sugar dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_14765</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN12056.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN12056">
        <property type="protein sequence ID" value="PJN12056"/>
        <property type="gene ID" value="CG723_14765"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012938">
        <property type="entry name" value="Glc/Sorbosone_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011041">
        <property type="entry name" value="Quinoprot_gluc/sorb_DH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07995">
        <property type="entry name" value="GSDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50952">
        <property type="entry name" value="SSF50952"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014793053" evidence="1">
        <location>
            <begin position="28"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="domain" description="GSDH" evidence="2">
        <location>
            <begin position="50"/>
            <end position="368"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN12056.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="379" mass="40113" checksum="E4EE48309DE8DB1A" modified="2018-04-25" version="1">MKFRTRSSAIIGTICLAASLAFATAYADEPAAPPRAAAGVALTEVATAQNPTAGAAGPDGTVWIAERAGTVRVLDDRGLGEPVLDISSETTTDGERGLLGVAFDSGFEHFYISYTDLEGTSTIDEFAVQYGAIQTDSRRTVLTQTQPYENHNGGDIKFGPDGYLYIAFGDGGSGGDPQGNGQRLDTLLGKLLRIDPSGGEPYAVPADNPFVDDPDAKDEIWSYGLRNPWRFSFDSGTGDLLIGDVGQSDWEEIDWASADSEGGENYGWASMEGTHPFRGGTEPANHVPPVHEYDRNGLGCSVTGGYVYRGDAIPDLQGQYLYSDYCDGTMRGLTIENGEVTGRSDLGVNGGEVVSFVEDGDGELYVLALGGSISRIDPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JYZ1</accession>
    <name>A0A2M9JYZ1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CG723_08820</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN12103.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN12103">
        <property type="protein sequence ID" value="PJN12103"/>
        <property type="gene ID" value="CG723_08820"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010843">
        <property type="entry name" value="Uncharacterised_AroM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07302">
        <property type="entry name" value="AroM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PJN12103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="226" mass="23677" checksum="1A01CCE61203BFF0" modified="2018-04-25" version="1">MHAVTFLTIGQAPRPDLSQAIEAYLPATARVRHAGVLDGLTRPEVEARFAATRGRATLLSRLADGGSVTLDAEAVGAGLQTRVDQVEDEGADVVVLLCTGEFSGLRTRRARLVEPDALVTGYVATVLRGSQVGIVVPLPEQVTEAREKWRDIIPAPAFATASPYADDHLALSAAARTHLEAGATALMLDCMGFGTRHRKALRADGVTVPVLTPAAVVGAALGPMLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JZ67</accession>
    <name>A0A2M9JZ67_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Histidinol phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_11645</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN12160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN12160">
        <property type="protein sequence ID" value="PJN12160"/>
        <property type="gene ID" value="CG723_11645"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010996">
        <property type="entry name" value="DNA_pol_b-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027421">
        <property type="entry name" value="DNA_pol_lamdba_lyase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004013">
        <property type="entry name" value="PHP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003141">
        <property type="entry name" value="Pol/His_phosphatase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016195">
        <property type="entry name" value="Pol/histidinol_Pase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017078">
        <property type="entry name" value="UCP036978_PHPhdr"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14716">
        <property type="entry name" value="HHH_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02811">
        <property type="entry name" value="PHP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036978">
        <property type="entry name" value="UCP036978_PHPhdr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00481">
        <property type="entry name" value="POLIIIAc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47802">
        <property type="entry name" value="SSF47802"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89550">
        <property type="entry name" value="SSF89550"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="POLIIIAc" evidence="1">
        <location>
            <begin position="102"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN12160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="349" mass="37562" checksum="AEA9A4C1914C2F38" modified="2018-04-25" version="1">MEPVEALERVAFLLERTLAPPYRAGAFRTAAQVLGALPEGEVAERAAAGTLESLKGVGPKTAQVVREALAGEVPAYLEGLESEGAAAPLAEGGERLRSLLRGDCHLHSDWSDGGSPIEEMGRAAIALGHEWAALTDHSPRLTVARGLSPERLREQLAVVAELNKRWAPFRLLTGIECDILADGSLDQEPELLDRLDLVVVSVHSKLRMDAPAMTRRMVAAVTNPLADVLGHCTGRLVTGRNKVGRGRPESQFDAEAVFAACAESGTAVEINSRPERLDPPRRLLREAVAAGTLFSVDTDAHAPGQLDWQHLGCARAEECEVPADRVVNTWPADELLTWTRTRRAPSRAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JZA0</accession>
    <name>A0A2M9JZA0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CG723_13330</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN12205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN12205">
        <property type="protein sequence ID" value="PJN12205"/>
        <property type="gene ID" value="CG723_13330"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PJN12205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="457" mass="49378" checksum="7C62270E63E51CA0" modified="2018-04-25" version="1">MPASGSGSASSAAPARRPASTACPAHLAGKATCYTGQDSNGAYYAIAVPKTWNGSLVVHAHGGPDLGAGSDPERSVDDLNRWAVMVDEGYAWAGSSYRRGGYGTRMAAADTENLRRLFVGEFGNPRRTYVHGQSWGGNVAAKVVEAYGAGKHGPYDGALLTSGVLGGGSRGYDYRVDLRVVYQYYCRNHPRPTEPQYPLWEGLRADSTMTAAGLRARLQECTGYASEPKERTATQQRNLDDILAVTKIPERTLESHLRFATFTFRDIVHSRLGGRNPFSNQGVRYSGSHDDRALNAGVERFSADPTAVRDLSYDSDLTGKVTIPVLTMHAIGDPTAFVEHEAAYRASLQGAHRERHLVQTFTRESEHSELSNSEYANSITALDAWVRTGKKPTPNAIAASCAAFDGRYGTGCFYDPGFSPSAYASRVNPRPGGLRWPAMTAAQEKTWSRIDGVGIAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JZS2</accession>
    <name>A0A2M9JZS2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_04840</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000002">
        <property type="protein sequence ID" value="PJN12381.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN12381">
        <property type="protein sequence ID" value="PJN12381"/>
        <property type="gene ID" value="CG723_04840"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014754219" evidence="1">
        <location>
            <begin position="29"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN12381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="214" mass="20980" checksum="F2F479170BF0D57A" modified="2018-04-25" version="1">MKSPLKKTALVVAAAGAALGLAAAPSSAASTNWAVGPNSPETVTATSSNVLLGVNGIDMTCTYADATAALQSATGNPAQVGTIAPANFGRSGEPCTSILGNVTTTTTTPWRLWVEGDYDAATGTSPGFIDNIKATVTVATCSFDVTGTAHGSYKNGGTGTAGKLTVATNATELTTSNVSAGCAGIISNGDHPSFNGVYDVVVSGTSNGATIVGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K008</accession>
    <name>A0A2M9K008_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Biliverdin-producing heme oxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_05305</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000002">
        <property type="protein sequence ID" value="PJN12456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN12456">
        <property type="protein sequence ID" value="PJN12456"/>
        <property type="gene ID" value="CG723_05305"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004392">
        <property type="term" value="F:heme oxygenase (decyclizing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006788">
        <property type="term" value="P:heme oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd19165">
        <property type="entry name" value="HemeO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.910.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002051">
        <property type="entry name" value="Haem_Oase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016053">
        <property type="entry name" value="Haem_Oase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016084">
        <property type="entry name" value="Haem_Oase-like_multi-hlx"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10720">
        <property type="entry name" value="PTHR10720"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01126">
        <property type="entry name" value="Heme_oxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000343">
        <property type="entry name" value="Haem_Oase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00088">
        <property type="entry name" value="HAEMOXYGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48613">
        <property type="entry name" value="SSF48613"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0349">Heme</keyword>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="1">
        <location>
            <position position="10"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="2">
        <location>
            <position position="17"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="125"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="174"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR000343-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000343-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN12456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="216" mass="23875" checksum="134D61D4662BF9CB" modified="2018-04-25" version="1">MDTPFSTLIRTASHEQHTEAESTTFMSDLLGGALGVDAYARYTEQLWFVYRALEGAAGRLEGSAVAGPFIQAELFRVSAIERDLAHLRGDGWRDGVSALPATQAYASRVAECAREWPGGYVAHHYTRYLGDLSGGQIIRDKAEKNWGFARKGDGVRFYVFEQVPNPAAFKRSYRALLDGVRVDELEKQRIVAECKRAFALNTAVFKALGEEFSSAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K0A0</accession>
    <name>A0A2M9K0A0_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 9">Quinolinate synthase</fullName>
            <ecNumber evidence="2 9">2.5.1.72</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">nadA</name>
        <name evidence="10" type="ORF">CG723_05850</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CB01635</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>dihydroxyacetone phosphate + iminosuccinate = H(+) + 2 H2O + phosphate + quinolinate</text>
            <dbReference type="Rhea" id="RHEA:25888"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29959"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
            <dbReference type="ChEBI" id="CHEBI:77875"/>
            <dbReference type="EC" id="2.5.1.72"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="9">Binds 1 [4Fe-4S] cluster per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 9">Cofactor biosynthesis; NAD(+) biosynthesis; quinolinate from iminoaspartate: step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the quinolinate synthase family. Type 3 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.72" evidence="2 9"/>
    <dbReference type="EMBL" id="NNBL01000002">
        <property type="protein sequence ID" value="PJN12555.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN12555">
        <property type="protein sequence ID" value="PJN12555"/>
        <property type="gene ID" value="CG723_05850"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00253">
        <property type="reaction ID" value="UER00327"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008987">
        <property type="term" value="F:quinolinate synthetase A activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009435">
        <property type="term" value="P:NAD biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10800">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00569">
        <property type="entry name" value="NadA_type3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003473">
        <property type="entry name" value="NadA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036094">
        <property type="entry name" value="NadA_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023515">
        <property type="entry name" value="Quinolinate_synth_A_type3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30573">
        <property type="entry name" value="PTHR30573"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02445">
        <property type="entry name" value="NadA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF142754">
        <property type="entry name" value="SSF142754"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00550">
        <property type="entry name" value="nadA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 9" id="KW-0408">Iron</keyword>
    <keyword evidence="8 9" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="6 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 9" id="KW-0662">Pyridine nucleotide biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Iminoaspartate binding" evidence="9">
        <location>
            <begin position="167"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Iminoaspartate binding" evidence="9">
        <location>
            <begin position="288"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="71"/>
        </location>
        <ligand>
            <name>iminosuccinate</name>
            <dbReference type="ChEBI" id="CHEBI:77875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="88"/>
        </location>
        <ligand>
            <name>iminosuccinate</name>
            <dbReference type="ChEBI" id="CHEBI:77875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="135"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="188"/>
        </location>
        <ligand>
            <name>iminosuccinate</name>
            <dbReference type="ChEBI" id="CHEBI:77875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="262"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="305"/>
        </location>
        <ligand>
            <name>iminosuccinate</name>
            <dbReference type="ChEBI" id="CHEBI:77875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="352"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PJN12555.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="400" mass="43853" checksum="0DAC9E7E73C4BAE3" modified="2018-04-25" version="1">MRDVTTAQTTVDLDVQPTPLALLLLGREADPRSERGVECPGDLPSPSDPDLVERARAAKERLGDKVFVLGHHYQRDEVIQFADVTGDSFKLARDAAARPEAEYIVFCGVHFMAESADILTGDDQKVVLPDLAAGCSMADMATAEQVAECWDVLTEAGIADQVVPVSYMNSSADIKAFTGKHGGTICTSSNAKRALDWAFEQGEPNSTKVLFLPDQHLGRNTAVRDMGMSLEDCVLYNPHKPNGGLTAEELRNAKMILWRGHCSVHGRFSIDSVDDVRERIPGVRVLVHPECKHEVVAAADEVGSTEYIIKALDAAPAGSKWAIGTELNLVRRLANAHPDKEIVFLDKTVCFCSTMNRIDLPHLVWTLESLAEGNLVNRIEVDRETEQFAKQALERMLALP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K0Z0</accession>
    <name>A0A2M9K0Z0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glucose-6-phosphate dehydrogenase assembly protein OpcA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">opcA</name>
        <name evidence="2" type="ORF">CG723_07265</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000002">
        <property type="protein sequence ID" value="PJN12803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN12803">
        <property type="protein sequence ID" value="PJN12803"/>
        <property type="gene ID" value="CG723_07265"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004555">
        <property type="entry name" value="G6PDH_assembly_OpcA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38658">
        <property type="entry name" value="PTHR38658"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10128">
        <property type="entry name" value="OpcA_G6PD_assem"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00534">
        <property type="entry name" value="OpcA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="307"/>
            <end position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN12803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="356" mass="37782" checksum="CB7FE7C8AF351F45" modified="2018-04-25" version="1">MKIDLTDTTSSKINKALMEGRRSIGTPAVGMVLTLVIVTDEENAYDALRAANEASREHPSRTLVVIKRVSRSPRDRTTSRLDAEVRVGAEAGTGETVVLRLYGEVINHAQSVALPLLLPDAPVVAWWPVNAPLDPAKDPLGALAQRRVTDTYAAEQPNDELEARAGAYTPGDTDLSWTRITPWRSMLAAALDQVACKVNSVEVEGEEFNPSCELLAMWLADRLDVPVKRSVSSGPGLTAVRMETDCGAIVLDRPDGSLATLSIQGQPDRAVALKRRETSELIAEELRRLDPDDTYAAALKYGVHRLGEPAAAPDGQGPGADADAPAAASAPAKKTAAKKAPAKSAAKKSASKAAAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K170</accession>
    <name>A0A2M9K170_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_07590</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000002">
        <property type="protein sequence ID" value="PJN12866.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN12866">
        <property type="protein sequence ID" value="PJN12866"/>
        <property type="gene ID" value="CG723_07590"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="25"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="66"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="94"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="144"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="196"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="233"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="268"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="308"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN12866.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="336" mass="35523" checksum="0686ACA234FB607F" modified="2018-04-25" version="1">MTQTAAPASRTAPRPALRSGRLRRVLRAVAVVSCLPYLTLKIAWIGGSHLGIPEGSPLLDHRASMAAANSVTVLMDGAVIVLALLLTRPWGRRVPAWLLVFPMWVATGLLTPIMTGYPLQLLVRAFGGSVNHGGSKGGPFLDEWVFGVVYTGFILQGLALGTLFALYARDRWGHTWRGPVRELPPPPADAARRTPAVAAAVLALFPLTLHLLWACGATTGLSSARIADRSSDFYVLEATDVAFLAAAVLGALSLTFRRGGGLPVKLPLALAWLGSGAVACWGGWLALASLAGVDDITRRPTPVMNLTYAVQMIVGILVAAVGVRFLAGRAERRTAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K1X6</accession>
    <name>A0A2M9K1X6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_00565</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000001">
        <property type="protein sequence ID" value="PJN13129.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN13129">
        <property type="protein sequence ID" value="PJN13129"/>
        <property type="gene ID" value="CG723_00565"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="44"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="250"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="88"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="215"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="272"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="299"/>
            <end position="368"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN13129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="397" mass="39846" checksum="824D2ADF06CE721F" modified="2018-04-25" version="1">MGEKPETSQDAQEKPKGKRLDLNVPQVAGSAVAAVVAAKLAAGLGVYGTIVGAGVVSALATCGGSLFQHFFRRTGEQIRDVAGQAIPKGRQTPVTDDGRPVPETFRSDMVPASVTPPAATAAMRADVPPRTTSWGMSGASAQGADATTVLPALDAERTQLLTADAGDPDRTQLLTAGGAAAEKTQLLRVGAGAGPGAVDDATRVLRAAPADGGGVGAVRSELPPPPGDLGDEYTEGTTHRARVRSWKRPLVAAAVVFGVTMAGITTYELASGQSFSGDGQRTTLREAFTGGGGHPSRNDHTPVPSTSQEPSDSSSSGTQSGTPQDGGGRQTGDTVQPTPTPSASEDSHTGHDNGSGSGSGTGGDKSTPTPAPTPTPSTSESGDGADVPQQQDETPEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K2D8</accession>
    <name>A0A2M9K2D8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">3-oxoacyl-ACP reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_01570</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000001">
        <property type="protein sequence ID" value="PJN13296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN13296">
        <property type="protein sequence ID" value="PJN13296"/>
        <property type="gene ID" value="CG723_01570"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="299"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN13296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="318" mass="32650" checksum="88134832A346487D" modified="2018-04-25" version="1">MSDVSSGPLTSLDGKVAVVTGSGRGLGLAYAIALARSGASVVVNDIDADVAGRAVETITAAGGRAVAEVVPVGTTEAAERLVGRAVSEFGRLDVMVTNAGILRDRVLWKMTDDDFDAVVTTHLRGTFTCARAAAVRMRQQGEGGSLVLVASPAGQRGNFGQTNYAAAKAGIAAMVRTWSMELARAGVTVNAVVPVAATAMTETMPAFAPYVDALRGGEPLPGFLRRGEGFGTPEDCAALVPFLASEAARDVTGQCIGIGGDKLALWSHPQEVSVAYADGGWSPRTIAETWHTSVGREPQAVGIPAPRLPKAPEGVVPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K2X2</accession>
    <name>A0A2M9K2X2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC transporter substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CG723_02570</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CB01635</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial solute-binding protein 5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000001">
        <property type="protein sequence ID" value="PJN13471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN13471">
        <property type="protein sequence ID" value="PJN13471"/>
        <property type="gene ID" value="CG723_02570"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042597">
        <property type="term" value="C:periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030678">
        <property type="entry name" value="Peptide/Ni-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039424">
        <property type="entry name" value="SBP_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023765">
        <property type="entry name" value="SBP_5_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000914">
        <property type="entry name" value="SBP_5_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30290">
        <property type="entry name" value="PTHR30290"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00496">
        <property type="entry name" value="SBP_bac_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002741">
        <property type="entry name" value="MppA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01040">
        <property type="entry name" value="SBP_BACTERIAL_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014955087" evidence="3">
        <location>
            <begin position="42"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="domain" description="SBP_bac_5" evidence="4">
        <location>
            <begin position="101"/>
            <end position="468"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PJN13471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="549" mass="58769" checksum="D044C244487108A1" modified="2018-04-25" version="1">MSRTLVPWRRYLLVRRTAVAVTAVALVLSTTAGCGSLQSSATEVGGERMTDDRPVRDGGTLTVALNADPDKLDPSLAQTLVGRTVFAGMCEKLYDVDEAGKVVPQLATALPKTSADGRTVTFSVRKGLKFSDGTSLDAAAVVTSLLRHRDLPGSARATELTPLKGAEATGAYSVKLTLKQAYVPLTAVLADRSGMVMSPAALKKYGKNFTNHPSCVGPFKFVERVGGDRIVLAKDPNYYDARDVHLDKVIYKPIPDGSVRLANLRSGDVQIGDQMAPVDVKSALTEPKLQLFNSPSLGYQGIGLNVGNVKGLGQKPGKLDTPLARDVRVREAFELSIDRDLINKVVFQGMYEPACGPVSPESAIAPGVAASACPKRDVAKAKRLLKAAGVKTPLKIELKTSTTPENSRLGQVVQAMAKEAGFAVSLRPTEYATMLEETDSGHYDAFTSGWSGRLDPDGNIASFLQTKGAMNAYGFSDDETDALIERGRTEADPAERAQIYGELTRRANDAHALVYLYRQKNYVVAGKDVAGIRVYGDGLVRVKDAGYAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K2X9</accession>
    <name>A0A2M9K2X9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">PucR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CG723_02670</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CB01635</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CdaR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000001">
        <property type="protein sequence ID" value="PJN13486.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN13486">
        <property type="protein sequence ID" value="PJN13486"/>
        <property type="gene ID" value="CG723_02670"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2840">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041522">
        <property type="entry name" value="CdaR_GGDEF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025736">
        <property type="entry name" value="PucR_C-HTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042070">
        <property type="entry name" value="PucR_C-HTH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17853">
        <property type="entry name" value="GGDEF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13556">
        <property type="entry name" value="HTH_30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GGDEF_2" evidence="3">
        <location>
            <begin position="176"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="domain" description="HTH_30" evidence="2">
        <location>
            <begin position="335"/>
            <end position="392"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF17853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PJN13486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="399" mass="44279" checksum="E4149E3189353E61" modified="2018-04-25" version="1">MSRRRPRTGQDWRLLRETCTELLERVPELVDEHLRQLSAYSEVYGRVLPYDVRWREAEEAMRIGIETIVAPRTSPRRDLEYAEESGRRRAGQGLPVDLLVHAYRNAGYLVWDALLESPAGQDPEKLAVLMRSATMVWAAVDAQAAAAAEAYRATEMELRRRTDEQLQALLDALLEGRPAPGLAARAAAGLDLPEHGPYAVVVLRVDRRDGREAFHRRIQNPGFRFIWRMRTDCEVGVVALGSGEGLDELTALLDGRCPGPGGVSPVVAGLAELGHARRLAELALRTCPPDATGIVRLDRRMPTALVVSQPELAGRLVTDVFGEVLALEPGDRAVLLETLDAWLSCEGSAGRAAGRLYCHRNTVFNRLRRLEQLTSRSLSRPRDLMEMTLALDAYRLSPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K2Y1</accession>
    <name>A0A2M9K2Y1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CG723_02075</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000001">
        <property type="protein sequence ID" value="PJN13387.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN13387">
        <property type="protein sequence ID" value="PJN13387"/>
        <property type="gene ID" value="CG723_02075"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009351">
        <property type="entry name" value="YcaQ-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06224">
        <property type="entry name" value="HTH_42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PJN13387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="382" mass="42214" checksum="AF14E8842D96E59E" modified="2018-04-25" version="1">MTTKRSTAKASVSNAAGPTLSARALGRATLDRQFLLRRSPVTVKAAVEHLLGLQAQNVKPPYGALAARLDGFDPAELSRLLEDREVVRIVTMRSTIHLHSADDCMSLRPLVQPARERELKMFAKGLPGVDLDRLTALTKAYVEQAPRTPRQIRELLLAEWPDADPLALTIAARCRLPLVQTTPRGLWKRSGQVALTTAEHWLDRAADPAPAPDGTVLRYLAAFGPASVKDMQQWAGLTRMREVFERLRPQLVTFHDPHGVELFDLPDAPRPDEDTPAPPRLLPEFDNLLLSHADRTRLVPLAYKDRTWKANMSFPAFLVDGMLAGLWKLDEAKDASATLTLQPFGKLTAGQRDALTDEAETTARTLGVKGPCDIRFGTVRPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K318</accession>
    <name>A0A2M9K318_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">AraC family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_02565</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000001">
        <property type="protein sequence ID" value="PJN13470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN13470">
        <property type="protein sequence ID" value="PJN13470"/>
        <property type="gene ID" value="CG723_02565"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.80.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010499">
        <property type="entry name" value="AraC_E-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029442">
        <property type="entry name" value="GyrI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011256">
        <property type="entry name" value="Reg_factor_effector_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06445">
        <property type="entry name" value="GyrI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00871">
        <property type="entry name" value="AraC_E_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55136">
        <property type="entry name" value="SSF55136"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="1">
        <location>
            <begin position="6"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN13470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="286" mass="32032" checksum="8280B542FE8DD83E" modified="2018-04-25" version="1">MLDRLNEAMDHIERHLDQRIEITELARIAATSEYHFRRMFSALAGLPLSEYIRRRRLTVAGAEVLSGERTLLEIAVRYGYGSGEAFARAFRGLHGVGPGEARRTGAALRSQPRMSFRLIVEGSSTMRYRVMEKPEFHVVGRKARVPLVHEGMNPAIADFVRGIDKETVRRIHALSDQEPEGIVSVSDDLDPSRAEGTELDYYHAVVASAAGPDDLDTLVVPAGTWAVFDSSGPFPQTLQHLWRDVFTQWFPSNPYRSRPGPEILSTRLSPDAAQADAQLWIPVERE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K3C6</accession>
    <name>A0A2M9K3C6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Sugar hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CG723_03510</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000001">
        <property type="protein sequence ID" value="PJN13631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN13631">
        <property type="protein sequence ID" value="PJN13631"/>
        <property type="gene ID" value="CG723_03510"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.920.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037398">
        <property type="entry name" value="Glyco_hydro_64"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032477">
        <property type="entry name" value="Glyco_hydro_64_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042517">
        <property type="entry name" value="Glyco_hydro_64_N_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037176">
        <property type="entry name" value="Osmotin/thaumatin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38165">
        <property type="entry name" value="PTHR38165"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16483">
        <property type="entry name" value="Glyco_hydro_64"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014942145" evidence="2">
        <location>
            <begin position="34"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_hydro_64" evidence="3">
        <location>
            <begin position="37"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="384"/>
            <end position="408"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF16483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PJN13631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="408" mass="44008" checksum="3111F9240A02D6B3" modified="2018-04-25" version="1">MISRRLFLTGAATAATALTYPAWGSALSPDADAAPATCELALQNKSLPGTVRAYVTGHEQGTDRWVLLKPDGGVYHPDSPSAPQTPLPVDCAIPLGAAGSAPKVLTLPQMYGARVYFVRDNTLDFFLNPGPALVEPAFATSTDANYAKTWSFCEFTFNSDQLYANISYVDLVTALPIGLTLEGDATHTVAPLPDGAVDRIAADLAAQTAKDGQPWDKLVIRGGDGKVLRVISPQNLMAPYFDRPDEMPFRDVWDSYVDQVWEKYRTTDLKIDLQGGRSVFTGRVSGDTLTFNGGHSFPKPASKDIFTCNHGPFTNNPGDPDDKKGLLARLAAGFNRSIMLTHPEQPNGTTTADYYQGDVTNHWSRVVHANSPIGYAFPYDDVRPDGQPDVSGAAHDGNPRRFTVSVGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K3J7</accession>
    <name>A0A2M9K3J7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Polysaccharide ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CG723_03915</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CB01635</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000001">
        <property type="protein sequence ID" value="PJN13695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN13695">
        <property type="protein sequence ID" value="PJN13695"/>
        <property type="gene ID" value="CG723_03915"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="33"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="64"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="106"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="146"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="193"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="253"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="60"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PJN13695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="292" mass="31865" checksum="D0396D5EAF14EA46" modified="2018-04-25" version="1">MLLLTLPGLLYFCVFHYVPLLGYVVAFQDYQPYLGYMHSAWAGVSNFTSAFADPAFWSATGNTLKIALVQLVFFFPVPIALALLLNSIVSDKVRRFVQSVVYLPHFIGWVIIVSIFQQILGGAGVLPDLLGQLGLPRYDMTTDPAAFPWLLTLQVAWKDAGWGTIIMLAALLNIDRGLYEASAIDGAGRARRLWHVTLPGISPVIILLLILNLGQILSVGFEQILLQRDAVGPAAGEVLDTYVYFHGIKNNDWGTSAAVGLVKAVIGTVLVLGANKFAHRLGHEGVYRGADR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K3K4</accession>
    <name>A0A2M9K3K4_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF4157 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_04025</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000001">
        <property type="protein sequence ID" value="PJN13711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN13711">
        <property type="protein sequence ID" value="PJN13711"/>
        <property type="gene ID" value="CG723_04025"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025295">
        <property type="entry name" value="DUF4157"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026835">
        <property type="entry name" value="YqcG"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13699">
        <property type="entry name" value="DUF4157"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14410">
        <property type="entry name" value="GH-E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4157" evidence="2">
        <location>
            <begin position="39"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="718"/>
            <end position="745"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN13711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="909" mass="98669" checksum="880802B8817E5197" modified="2018-04-25" version="1">MSLPVHAGDRRVQQTTAIPVESSAVPAEVDGVVRSPGRPLDQQTRTFMELRFGRDFGGVRVHTDAAAARSARSIHALAYTVGQHIAFDTGRFSPATHEGRLLLAHELTHVAQQTDAFGGAIRPSIQRQKAPAPTEVRERPGLAIYLTNPDVDNLEAELLRRGILKPGQYDLRRFAGDGYYFAKSSGSGSTSGHVAVLDAPAIRNSAGAIIGFRIISHLPGASQGSQPGPPVPAKDTGWLEEQFLALPEPTKALLKEAAELHPENLDQVLRIAAKIDRLEPEDRQVYKPIAKRLATNLDTFERSIDAYTEFKSNIKAQENSEKKTDASGKEETLQQKLSKTWSRFDESKMAGMTPAQKEGLAREVAAEQSNIQLEHMAAHPGETAVGMAEGMVRVDKTAKQIVEDVQEAADGNKSGYARIAGAAGAYNKYVAAAASVAFVALLFIPGVNVLELTMFGLATAAVTIAGSAAESELRIKAAGEAKTVEDFKSHTAKAAEAQTRIVVAAAMLALTLVAKLVARIPLPGRYQNVGAALRSAQNSLLEKSGVGPAWQSIKSELLTKLRASRQGLPEALTEESKVVVAAAKDVEVMTGEEFVQHLADGDPKLADLDISPEQAKGIQRLAAATPDGANVAEQLRRNALQALRDVPPEAAKRVDNFIKDVDGSVKSVESAKNPDQLKSSIELGNQKFGPENQARRALAEEQSFTKKRRVGARRRALEAQARVDLDKLAAEMEDTQARMAEAKDEYFTAVRKVIALNKKVKGTPAGSDAHTVAQRELDAAEEALAEIKEKDSLAGQWKKAEDLKDQEAKVFASLKLGRPGLWVSTRKKIRDATKMVNGKYIDFKERPIEGKPVYGHVTGREARRLVLEAAEKGMTQEQFNQWVNEHPEWFRLEQADRNLSHADELPGSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K3N0</accession>
    <name>A0A2M9K3N0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ABC transporter substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CG723_00190</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CB01635</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the bacterial solute-binding protein 3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000001">
        <property type="protein sequence ID" value="PJN13719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN13719">
        <property type="protein sequence ID" value="PJN13719"/>
        <property type="gene ID" value="CG723_00190"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015276">
        <property type="term" value="F:ligand-gated ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001320">
        <property type="entry name" value="Iontro_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018313">
        <property type="entry name" value="SBP_3_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001638">
        <property type="entry name" value="Solute-binding_3/MltF_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00497">
        <property type="entry name" value="SBP_bac_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00062">
        <property type="entry name" value="PBPb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00079">
        <property type="entry name" value="PBPe"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01039">
        <property type="entry name" value="SBP_BACTERIAL_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014670484" evidence="4">
        <location>
            <begin position="23"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="domain" description="PBPb" evidence="5">
        <location>
            <begin position="70"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="domain" description="PBPe" evidence="6">
        <location>
            <begin position="70"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PJN13719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="306" mass="32385" checksum="2E18C2CF38AF796A" modified="2018-04-25" version="1">MKLRKSAAAAATVAVLALTATACGGDSGNAGDKPAGGAGGKDQPKLPTYTVASGVKLDSATLKRAQKAGKLVIGAKNDQPYLGFQDTDGKRSGFDIEIAKMVAADLGFKPSQIEFKTIDSNVRETTISKGEVDLYVGTYTINDERKKQVGFAGPYFMAGADLLVRGDEKGITGPDSVKGKSVCSIKGSTPLQEIKKPKYGAKTVELSKYSECVQQLLNNEVDAVTTDDAILKGYAAQRPGKLKVVGKPFTEEPYGVGMNKDDKALREAVSKAIEAHEKNGDYKKAYDATLGLSKSAYTAPPALERY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K3N6</accession>
    <name>A0A2M9K3N6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CG723_00985</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000001">
        <property type="protein sequence ID" value="PJN13735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN13735">
        <property type="protein sequence ID" value="PJN13735"/>
        <property type="gene ID" value="CG723_00985"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003959">
        <property type="term" value="F:NADPH dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02932">
        <property type="entry name" value="OYE_YqiM_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001155">
        <property type="entry name" value="OxRdtase_FMN_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044152">
        <property type="entry name" value="YqjM-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43303">
        <property type="entry name" value="PTHR43303"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00724">
        <property type="entry name" value="Oxidored_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD_binding_3" evidence="3">
        <location>
            <begin position="5"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="domain" description="Oxidored_FMN" evidence="2">
        <location>
            <begin position="386"/>
            <end position="719"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="732"/>
            <end position="758"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PJN13735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="758" mass="82500" checksum="7BD0F81EB8638D84" modified="2018-04-25" version="1">MGPLRVAVIGGGPGGLYAAVLLKRLDPRRDITVWERNAPDDTFGFGVVLSDETLGGIEHADPVVHAALQAEFVRWDDIDVVHRGTRRTSGGHGFAALGRRRLLEILHERCRQLGVNLRFRSEAPSAADLARDHDLVVAADGVRSATREAHADAFRPHIEEHRCRYIWLAADFAFDAFRFETAETEHGVMQLHGYPFSASDSTVIVEMREEVWRAAGFDGLDVRESVERCAKIFTEALGGRGLRSNKSAWTAFRTVVNETWSHGNVVLVGDAAHTAHFSIGSGTKLAVEDALALAACLQEQPTTAEALAAYEAERRPVVASTQRAARASLEWFENLGLYLDQPSRQFAFNLLTRSRRVTHDNLRLRDPGFTEAVERDFGCPPGTPPMFTPLRLRELTLRNRVVVSPMDMYSSRDGVPGDFHLVHLGARALGGAGLVMTEMVCVSPEGRITPGCAGLYTPEQAAAWRRITEFAHAQAPGTAIGVQLGHSGRKGSTKLMWEGIDDPLPHGNWPLVAASPLPYKPGSQIPHELTQDELGDVREQFTSAAVRAADAGFDLLELHCAHGYLLSGFLSPLSNHRTDAYGGSLTNRLRFPLEVFDAVREVWPGDRPMTVRISATDWAEGGTDAADAVEIARAFAAHGADAIDVSTGQVVADEKPAYGRSYQVPFADRIRNETGIPVISVGAISSWDDVNSLILAGRTDLCALARPHLYDPHWTLHAAAEQGYAGPGVAWPKPYEAGSRPPQTGRLDAPKPRLTLGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JEZ2</accession>
    <name>A0A2M9JEZ2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CG723_44845</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000048">
        <property type="protein sequence ID" value="PJN05466.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN05466">
        <property type="protein sequence ID" value="PJN05466"/>
        <property type="gene ID" value="CG723_44845"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PJN05466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="107" mass="11709" checksum="4ADE2C61B851827F" modified="2018-04-25" version="1">MTDYDTYGTSSHTASELVRLVGGRLGLAFTEHDSHFRGIYHRADSLDGQIEIQPNPIPGDDGEDDLYATEHPTVQVLLLTTTPAPNPALRAQLNAVEGLAHLKNESW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JF42</accession>
    <name>A0A2M9JF42_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CG723_44150</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CB01635</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000046">
        <property type="protein sequence ID" value="PJN05516.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN05516">
        <property type="protein sequence ID" value="PJN05516"/>
        <property type="gene ID" value="CG723_44150"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="73"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="110"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="147"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="172"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="205"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="237"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="327"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="364"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="392"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="418"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="454"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="489"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="7">
        <location>
            <begin position="77"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="522"/>
            <end position="550"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PJN05516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="550" mass="58342" checksum="036649CF041B2564" modified="2018-04-25" version="1">MMTPAASKDPEGREQGSCGGGGGIAPDGSRGPGKERGRRPDPLDEAAAPGSSGLGVITTAVPARLDRLPWSRWHWMIVIGLGTVWVLDGLEVTTVGNIASRLSEEGSGLAITSAQVTGLAAALYVAGACSGALFFGWLTDRFGRKKLFMVTLAVYLAATAMTGLSFSAWWFFLFRFLTGFGIGGEYAAINSAIDELIPSKYRGRVDLVINGSYWLGAVGGALLSIVMLNTDYFPKDLGWRLTFALGVVLGLVILLVRRHVAESPRWQLIHGHREDADKLVDSVEREIEDEKHEELPPPTSEITIHERKSIGFGLIAKTVFRSYPKRAVLGLSLFIGQAFLYNAITFGFGAILTTFFDVESGHTGYYFAVIAAGNFIGPLVLGKLFDTVGRRIMIAGTYIVPGILLFITAWLFDRGSLTANTLTACWCVVLFFASAGASSAYLTVSEVFPMETRAMAIAFFYAIGTAVGGISGPLIFADLTASGVPGDTALAFAIGAALMCAAGLVAAFLAVNAEQRSLEDIARPLSQTEKRGTQRPDSGGGPAPVGDTAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JG88</accession>
    <name>A0A2M9JG88_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_42270</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000039">
        <property type="protein sequence ID" value="PJN05896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN05896">
        <property type="protein sequence ID" value="PJN05896"/>
        <property type="gene ID" value="CG723_42270"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045596">
        <property type="entry name" value="DUF6459"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20060">
        <property type="entry name" value="DUF6459"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN05896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="150" mass="16936" checksum="F2E34072926CAB9C" modified="2018-04-25" version="1">MDQPRRRPRTTRPPGGRPPGRQDTRRPGAPPVRVPPQLPPHPAELFTERLLLMLSGQRPVHWASRHFAGSLFDALIRLAEDQPLSDRGHRPVVRGIGHYEPEPGVFEVFARISAGPRLHALAFRLHRGDDHRWLCTAVEMSGRPPRDSEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JGA8</accession>
    <name>A0A2M9JGA8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CG723_42925</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000041">
        <property type="protein sequence ID" value="PJN05787.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN05787">
        <property type="protein sequence ID" value="PJN05787"/>
        <property type="gene ID" value="CG723_42925"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PJN05787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="259" mass="25049" checksum="28BB4FACAA7574B4" modified="2018-04-25" version="1">MEKRVVGRFAALAAGAVVARAGFAALRRARPGGPGLWERTNFAGRAVDLCAGPAVVAGAVAGAAAATSGRDRRAAVLAVLAAGACGAYDDVAGAGDPRSGFRAHLSALRDGELTSGAVKLIGISAAGLAAGSLLEERIVDKALAGVVIAGAAHFVNLVDVRPGRAAAAVLALGAPGLLKGAVAAAPMGAVAAVLPEDLDGRTMIGDTGAHALGAALGVAVVAGNGRAGLLAHAAGLVLAAAYGDKVTAWARGAESVRHT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JGS3</accession>
    <name>A0A2M9JGS3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CG723_41550</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000036">
        <property type="protein sequence ID" value="PJN06079.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN06079">
        <property type="protein sequence ID" value="PJN06079"/>
        <property type="gene ID" value="CG723_41550"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="6"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="38"/>
            <end position="45"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PJN06079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="318" mass="34129" checksum="E25E289C4AA7455F" modified="2018-04-25" version="1">MTSLAIAANGLRKSYGDKIVLDGIDLVVPEGTVFSLLGPNGAGKTTAVKILSTLIGADAGELRVGGHDLAADAHAARAAIGVTGQFSAVDGLITGEENMLLMADLHHLSKREGRRVAAELLERFDLTDAASKPASTYSGGMKRRLDIAMTLVGNPRIIFLDEPTTGLDPRSRHTMWGIIRELVSDGVTVFLTTQYLEEADELADRIAVLNDGKIAAEGTAEELKRLIPGGHIRLRFTDPAAYQQAATVLHDAARDDEALALQMPSDGSQRELRSILDWLDSAGIEADELTVHTPDLDDVFFALTSDNKVPTQPKENVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JGS5</accession>
    <name>A0A2M9JGS5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CG723_41295</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000036">
        <property type="protein sequence ID" value="PJN06042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN06042">
        <property type="protein sequence ID" value="PJN06042"/>
        <property type="gene ID" value="CG723_41295"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PJN06042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="341" mass="37166" checksum="4F2EBEE7E3A43971" modified="2018-04-25" version="1">MGSALIATGADATVVIVEAGDSPGVSGVQDSTKVLLRGDTVPVLYPRFDFESPLPIRLFARMDGGCLPLGAARCRGLSDPANFDYAALELDQPLTREMLDVVRPVPAPGAVPDVDWVDHVDADPIRALESFALGWFPAEEPELAEEGNAAGELGSLPEALVAFRRVARLRPALRRFHDPVLEQPKRASGPFGDRLVFAVQDGAGMDWSIPWPVEGPGVADPRVWCTDDPCGSEPEAFIEEEPLSRFLLQFTLYEATIAAPYQAWTYCMPTARLDTLWSMLRPIPLSPFLPTYTAEKFFVAPGLLMSASMDESEAVVAFGALHRATLTPLLEHGFRWSRFDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-05-25" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JH31</accession>
    <name>A0A2M9JH31_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">CBS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_40625</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000034">
        <property type="protein sequence ID" value="PJN06181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN06181">
        <property type="protein sequence ID" value="PJN06181"/>
        <property type="gene ID" value="CG723_40625"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="SSF54631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CBS" evidence="1">
        <location>
            <begin position="31"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN06181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="134" mass="14201" checksum="18F40976D75BCB16" modified="2018-04-25" version="1">MTLVQMQPRPASTNPVQRKTVEARDAAGPQVCDDMSVEVALSVMAAAHTGRLAVCDQDGQRTGLVTQTELTAVRDSSAYTDRVRLRDITGDHGSFTSPEATGSESEHVLRSRRLGALPVIDGQGSALGVLALSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-05-25" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JI13</accession>
    <name>A0A2M9JI13_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7">Aminomethyltransferase</fullName>
            <ecNumber evidence="3 7">2.1.2.10</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6 7">Glycine cleavage system T protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7 10" type="primary">gcvT</name>
        <name evidence="10" type="ORF">CG723_38830</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CB01635</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">The glycine cleavage system catalyzes the degradation of glycine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>(6S)-5,6,7,8-tetrahydrofolate + (R)-N(6)-(S(8)-aminomethyldihydrolipoyl)-L-lysyl-[protein] = (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + (R)-N(6)-dihydrolipoyl-L-lysyl-[protein] + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:16945"/>
            <dbReference type="Rhea" id="RHEA-COMP:10475"/>
            <dbReference type="Rhea" id="RHEA-COMP:10492"/>
            <dbReference type="ChEBI" id="CHEBI:15636"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="ChEBI" id="CHEBI:83100"/>
            <dbReference type="ChEBI" id="CHEBI:83143"/>
            <dbReference type="EC" id="2.1.2.10"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="7">The glycine cleavage system is composed of four proteins: P, T, L and H.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the GcvT family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.2.10" evidence="3 7"/>
    <dbReference type="EMBL" id="NNBL01000029">
        <property type="protein sequence ID" value="PJN06500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN06500">
        <property type="protein sequence ID" value="PJN06500"/>
        <property type="gene ID" value="CG723_38830"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004047">
        <property type="term" value="F:aminomethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019464">
        <property type="term" value="P:glycine decarboxylation via glycine cleavage system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00259">
        <property type="entry name" value="GcvT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006223">
        <property type="entry name" value="GCS_T"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022903">
        <property type="entry name" value="GCS_T_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028896">
        <property type="entry name" value="GCST/YgfZ/DmdA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013977">
        <property type="entry name" value="GCV_T_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006222">
        <property type="entry name" value="GCV_T_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029043">
        <property type="entry name" value="GcvT/YgfZ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027266">
        <property type="entry name" value="TrmE/GcvT_dom1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43757">
        <property type="entry name" value="PTHR43757"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01571">
        <property type="entry name" value="GCV_T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08669">
        <property type="entry name" value="GCV_T_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101790">
        <property type="entry name" value="SSF101790"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00528">
        <property type="entry name" value="gcvT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GCV_T" evidence="8">
        <location>
            <begin position="11"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="domain" description="GCV_T_C" evidence="9">
        <location>
            <begin position="297"/>
            <end position="376"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00031395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF08669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PJN06500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="379" mass="40130" checksum="C43599C198FF508C" modified="2018-04-25" version="1">MNNVPRKTALDALHRSLGATMTDFAGWDMPLRYGSERDEHIAVRTKAGLFDLSHMGEITVTGPQAVDLLDYALVGNMSTIGPGRARYTMICQEDGGIVDDLIVYRLGEQEAGLPHYMVVANAGNAQIVLDAITERAAGFDAEVRDDRDAYALIAVQGPESPGILKSLTDADLDGLKYYAGLPGTVAGVPALIARTGYTGEDGFELFVAPEHAEKLWQALTDAGAPVGLVPAGLSCRDTLRLEAGMPLYGHELTTALTPFDAGLGRVVKFEKTGNEGRFVGREALEAAAERAETAPPRRLVGLIAEGRRVPRAGMSVVADGQVIGEVTSGAPSPTLGRPIAIAYVDAAHAAPGTEGVGVDIRGAHEPYEVVALPFYKRQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JI42</accession>
    <name>A0A2M9JI42_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ABC transporter substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_39155</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000030">
        <property type="protein sequence ID" value="PJN06427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN06427">
        <property type="protein sequence ID" value="PJN06427"/>
        <property type="gene ID" value="CG723_39155"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006059">
        <property type="entry name" value="SBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01547">
        <property type="entry name" value="SBP_bac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015000078" evidence="1">
        <location>
            <begin position="35"/>
            <end position="436"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN06427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="436" mass="46611" checksum="9BF662E8D92DD6A7" modified="2018-04-25" version="1">MALSRRNLLRGGLYGASAAALAPALSACGSIAEASSSAGGIQYWNPFTGGDGGLMKTMVAQVERRVSGLDAQSIVLEGGSSYYTKLAMSSAGGRAPDLAIMHMSRLAGYAPGGLLDPWDMDTLAEFGVTADQLNTDVFRRGHHDGVPYAIPLDTHPFVVFFDREVMAKADLVGSDGHLVPLKSPEGYLDAAERLRDVTKGGMGPVFGHVGDMAQSWRMFWSLYRQTGAEFDLTGRRIRIDRDTAVEIVGFMQKLTAPDCKHMDVGIAVGSFSSRSAPMIFSGEWDVLAFSQIKGIDLGAAPFPQLYDRPASWADSHAFVLPHQNDPDPQRRRTTHRLVAELLKASLTWAGAGHIPAYLPVVESRKYRSLEPQADYAAAAEATALEPSAWFMGAGSDAQGQMCQAMQPALIGTGTAAQAVDDMVSAINFSLGKPNPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JI75</accession>
    <name>A0A2M9JI75_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_38525</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000028">
        <property type="protein sequence ID" value="PJN06596.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN06596">
        <property type="protein sequence ID" value="PJN06596"/>
        <property type="gene ID" value="CG723_38525"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="47"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN06596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="83" mass="9386" checksum="2BDBE4288B6A2ED1" modified="2018-04-25" version="1">MNAQARTEREVRAILEAAQGALPPGIHTEAVRRGGRILRRRRVLRRLMWLALCLAMTAFFVWALLARPWVEPPSGTTPPLTGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JIC9</accession>
    <name>A0A2M9JIC9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Glycogen debranching enzyme GlgX</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">glgX</name>
        <name evidence="5" type="ORF">CG723_38930</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CB01635</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 13 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000029">
        <property type="protein sequence ID" value="PJN06517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN06517">
        <property type="protein sequence ID" value="PJN06517"/>
        <property type="gene ID" value="CG723_38930"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004133">
        <property type="term" value="F:glycogen debranching enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005980">
        <property type="term" value="P:glycogen catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02856">
        <property type="entry name" value="E_set_GDE_Isoamylase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044505">
        <property type="entry name" value="GlgX_Isoamylase_N_E_set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006047">
        <property type="entry name" value="Glyco_hydro_13_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004193">
        <property type="entry name" value="Glyco_hydro_13_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011837">
        <property type="entry name" value="Glycogen_debranch_GlgX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00128">
        <property type="entry name" value="Alpha-amylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02922">
        <property type="entry name" value="CBM_48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00642">
        <property type="entry name" value="Aamy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="SSF81296"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02100">
        <property type="entry name" value="glgX_debranch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aamy" evidence="4">
        <location>
            <begin position="214"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PJN06517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="765" mass="84969" checksum="D2FC13BCE466E8F1" modified="2018-04-25" version="1">MASAPEQEAPQDALVERPAGLPQARSAPGRKGRRTRERPPPVEPVRPGAPTPLGARFRVGPDGTAGTNFALWAGGAESVDLCLFDEAGRERRAPLTELTHEIWHGFVPDVLPGQRYGFRVHGRWDPWTGARWNPAKLLLDPYARAVDGDFGLPPEVYGHVRDWPEQHVADTVRDDRDSAPYVPKGVVVHDDAPDDEWADDRRPKTPWADSVIYELHVKGFTELHPGIPEELRGTYAGLAHPAAVEHLVKLGVTAVELLPVHQFAHEDHLLRRGLRNYWGYNSIGYFAPHAAYAASGTGGQQVGEFRRMVRALHEAGIEVILDVVYNHTAEAGELGPTLSLKGIDNRGYYRLQDDARRYADYTGCGNTLHVVQPHVLRLLTDSLRYWVTEMGVDGFRFDLAAALARSMHDVDMLSPFLAVIAQDPVLRRVKLIAEPWDVGSGGYQVGAFPPLWTEWNDRYRNAVRDFWRGALPDVRDLGYRLSGSSDLYAWGGRRPYASVNFVTAHDGFTLRDLVSYGRKHNEANGEGNRDGTDDNRAWNCGAEGETSDEDVLALRRRQLRNLLTTLLLSTGVPMLVAGDELGRTQRGNNNAYCQDNEISWVDWSLLEEPGWRSLFDLTSRLIALRHAHPVLRRRAFFSGRAHSADGLRDLAWFTARGTEMTERDWYAPAATLGMYLSGRDIPGRDALGAPVTDDSFLAVLHAGDGPESYVLPGEPWARTYEVVVDTSLEGQEEAPAVTHPAGAVITVPGRTVLLLRVRPWDNGEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JIJ1</accession>
    <name>A0A2M9JIJ1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_37825</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000027">
        <property type="protein sequence ID" value="PJN06705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN06705">
        <property type="protein sequence ID" value="PJN06705"/>
        <property type="gene ID" value="CG723_37825"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="29"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="56"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="81"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN06705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="116" mass="11533" checksum="6DB88547A5B052A3" modified="2018-04-25" version="1">MGAGAAAAVAGVGAVLALADISSPLRGPLTLFFLLTAPGAAIGSALRGLDPWGRWICAAAGAVALDLLVAEVMLATHRWSVTGGVVTIAVISVVGLVAPMVPARRLLGRAPGRRNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JIP4</accession>
    <name>A0A2M9JIP4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">SAM-dependent methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_37770</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000027">
        <property type="protein sequence ID" value="PJN06637.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN06637">
        <property type="protein sequence ID" value="PJN06637"/>
        <property type="gene ID" value="CG723_37770"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransf_11" evidence="1">
        <location>
            <begin position="60"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN06637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="211" mass="22553" checksum="1CE67A65782DEEF3" modified="2018-04-25" version="1">MRMSEDTTKRDMTPLGPVDWDTEAAAFDDEPDHGLRDPAVREAWAARLRDWLPDHPCDLLDLGCGTGSMSLLATDQGHSVTAVDLSPAMVDLARAKLAGRAARVLVGDAAAPPVAGETFDVILMRHVAWTLPDLDGALAHWLSLLRPGGRLILVEGVWGTLSPVGIPAARLTGALAPLVAHIRHEPLSGDALLWGRQVEDDRYAVVATLGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JIZ6</accession>
    <name>A0A2M9JIZ6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NADH dehydrogenase FAD-containing subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CG723_36790</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CB01635</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NADH dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000025">
        <property type="protein sequence ID" value="PJN06843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN06843">
        <property type="protein sequence ID" value="PJN06843"/>
        <property type="gene ID" value="CG723_36790"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003954">
        <property type="term" value="F:NADH dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006116">
        <property type="term" value="P:NADH oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045024">
        <property type="entry name" value="NDH-2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43706">
        <property type="entry name" value="PTHR43706"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyr_redox_2" evidence="3">
        <location>
            <begin position="8"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="445"/>
            <end position="465"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PJN06843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="465" mass="50541" checksum="AFA91CF5546ED4F6" modified="2018-04-25" version="1">MSTTERPRILVVGGGYVGLYAARRILKKMRYAEATVTVVDPRSYMTYQPFLPETAAGSISPRNVVVPLRRAVPGAEILTGRVTTIDQDRKVATVAPLVGEAYEVPFDYLVIALGAVSRTFPTPGLAEVGIGMKGVEEAIGLRNHVLEQLDKAESTNDEEIRRKALTFVFVGGGFAGAETIGEVEDLARDAAKFYKNVKREDMRFVLVDAADKVLPEVGPELGTYGRKHLESRGIEVYLKTTMPSCVDGHVVLSNGLEVDSNTVVWTAGVKPNPALARFGLPLGPRGHVDTQTTLQVQGSDYIWAAGDNAQVPDLVAVKNGTPAERAWCPPNAQHAMRQAKVLGDNVVSGMRGFPQKEYSHSNKGAVAGLGLHKGVAMIVMGKMKIKLKGRLAWYMHRGYHGLAMPTWNRKTRVIAEWTLNMFQKRDITALGALESPREEFYEAAKPAPAPAVAEAPKVEEKAKAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JKL8</accession>
    <name>A0A2M9JKL8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Thioesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_34305</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000021">
        <property type="protein sequence ID" value="PJN07327.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN07327">
        <property type="protein sequence ID" value="PJN07327"/>
        <property type="gene ID" value="CG723_34305"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006683">
        <property type="entry name" value="Thioestr_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03061">
        <property type="entry name" value="4HBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="SSF54637"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4HBT" evidence="1">
        <location>
            <begin position="30"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN07327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="152" mass="16942" checksum="C45CDADD818F213A" modified="2018-04-25" version="1">MTAEALARPAQSYGQLVPVAVHFDDLDALGLLHNARYPVMVERAWTALWAERGLVFEGDWVAAGDFCNAVKELRITYDAPVNRPGAYAVHLWLDRLGTTGLTYGFRFCSADGGTTYARGTRVLVRLDPATLRPAPWSEMFRTLGRELLRTQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JKQ5</accession>
    <name>A0A2M9JKQ5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">ATP-dependent acyl-CoA ligase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CG723_33715</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CB01635</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000020">
        <property type="protein sequence ID" value="PJN07456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN07456">
        <property type="protein sequence ID" value="PJN07456"/>
        <property type="gene ID" value="CG723_33715"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005324">
        <property type="term" value="F:long-chain fatty acid transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004467">
        <property type="term" value="F:long-chain fatty acid-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030310">
        <property type="entry name" value="FadD17/FadD6-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43107:SF15">
        <property type="entry name" value="PTHR43107:SF15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0436">Ligase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-binding" evidence="2">
        <location>
            <begin position="11"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding_C" evidence="3">
        <location>
            <begin position="402"/>
            <end position="476"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PJN07456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="496" mass="52776" checksum="D4D8BD13FFB10682" modified="2018-04-25" version="1">MNGMTLPGLVDAAADRFGDRTFLRMDSVRRTYEQTRSAAATMAGALAARGVLPGDRVAALMSNRVELVDLVLGCAWLGAVVVPLNTALHGRLLRHALSVAQPQCLYAEGELADRVAEVGYTGRVWTVGARDAPVPFAAAEADAYPSLPGDTAAILFTSGTTGPSRGVRCPQAQFVWWGRNVSDALRLGAEDTLYTCLPLFHTNALNCLAQAMTVGATVVVDGRFSASRYWARVAAADATCVYLLGAMVPMLLAQAAGPGDRAHRAWRALAPATPGELWVPFRERFGVGLVDGFGSTETNLVIGYTPDDVRPGYMGKVRDGFGARVVDAASAAVPDGAPGELMVRAEQSFAFATGYVGCDEEPPGAWRRTGDRVVREPDGWFRFVDRVKDCIRRRGENISSYEVEAAVLAHPGVAAVAAFPVASELAEDEVMVAVVPVDSVLEPADVVRHCVAELPGFAVPRFVDVVGELPLTETGKVRKGVLRERGVTGGTFDRFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JKQ9</accession>
    <name>A0A2M9JKQ9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Sugar kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_33630</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ROK (NagC/XylR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000020">
        <property type="protein sequence ID" value="PJN07442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN07442">
        <property type="protein sequence ID" value="PJN07442"/>
        <property type="gene ID" value="CG723_33630"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000600">
        <property type="entry name" value="ROK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18964">
        <property type="entry name" value="PTHR18964"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00480">
        <property type="entry name" value="ROK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN07442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="417" mass="43249" checksum="0F176C7EFA5ABFB8" modified="2018-04-25" version="1">MHKERERRPAVPSARPAPPGTPAQPVPVALHTVLTLVARSEAASRAEIARRSGLARSTVGHQIDELLRRGLITETVVGQSVRGRPPRTLTISPEAGTLAVVFVSPEATGVAVTDLNGDLIAQDTLDLRVETGPDTLLPAVAERVRTLLTEHGRTGSPVRQVVVGLPAPVDFVRGCPVRPPIMPGWDGFPVAARMTELLGAPTLVDNDVNLMALGEAERGTGGDVPLLCLSVGTGIGAGLVTAEGTVHRGADGAAGDVGHTRVPGHDEVLCACGKTGCLEAVASCRAILAALDMPEHTPDDPAHGLRLLCERLANGDAQALHEVGRAGVEIGEVVAILVLAFNPRTLILSGPVADACDELLASIRAVVYRRALSLATRKLVITTSQLGARAGLIGAVVLAVQQTFSRDGVGRLLGSAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JKR5</accession>
    <name>A0A2M9JKR5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Nitrate ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CG723_33770</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CB01635</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000020">
        <property type="protein sequence ID" value="PJN07466.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN07466">
        <property type="protein sequence ID" value="PJN07466"/>
        <property type="gene ID" value="CG723_33770"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="31"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="87"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="118"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="146"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="213"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="239"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="80"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PJN07466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="275" mass="29540" checksum="8391C3EFAC693C15" modified="2018-04-25" version="1">MTLTAADPKAPPRRTTAGTTARPGVRGLRTLAVYTLSVLVGLGIWQLLAMKYGSSLLASPAQTLSAAKELARDGTLFNSVVASSRRILIGWGLGILVGAPIGLLVGQIRIVRQLLEPYIEFFRFIPPVAFVTLAVVWLGIGESSKVVLIFYTAVFIVTLNTSTGVMAVNESKLRAAASLGASRRQILQRVVLPSTVPYIVTGARLAMGNSFLTIVSAEIVASQVGLGSLIWTSRNYGRIDWVFVGIITLGVLGFVYDRVLRLVAVRVLRRYGAKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JLG0</accession>
    <name>A0A2M9JLG0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_31950</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000018">
        <property type="protein sequence ID" value="PJN07692.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN07692">
        <property type="protein sequence ID" value="PJN07692"/>
        <property type="gene ID" value="CG723_31950"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="118"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="155"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="183"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN07692.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="555" mass="61331" checksum="9BC5E03ACF7E51ED" modified="2018-04-25" version="1">MGAAVADDVFDFRPGAQVPLHGSAGQTAATYALASAAYRDAKVDDLLAANSEWHKSDVKKGIWSLAAPNLGEAFSRAVQGRLLGGARKPLIQSFGTEPQVVVEHCLAANRIRKQRDSWLTAVMALCGLLFLPGLIVWLLVFQVRRMIGSQENKRMAALFTTLMVAVAAVAVIFMVKLPFTGFWAWYLRGAIVAPVIGWLWARQICERTAQDMRERWDSLLAGGGIGAKIPEAVPGSPGETAAERLRQSLAKLTAEQQSNSVFYAGPKGILGMGTRWGSWQLAEELIPRDEGAEIHPFRSWDVIRAVHDKLRLLERGPLHTGGFPTPSIKHWIVSPIGENAKKVARPSGTDVEAFQIKNHEIQRICNEQQFGSGDRHYLGVQFTLWDGQLVITMLITVTVLHETLRIEITGHALGPVHSLFTTKPEPKVKEVAKAIKFWETVEKKLPLIEPDEVVRLAVRAPFTWYPPLLDFIGGKLILPEPFGLRHAWADKPWRHRFMADDALRTATPVLRVVHAAAIKVLEENGVDTEKFGTRSSFLSNLVQAPTPMNADAYDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JLJ0</accession>
    <name>A0A2M9JLJ0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Methionine ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CG723_32135</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000018">
        <property type="protein sequence ID" value="PJN07722.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN07722">
        <property type="protein sequence ID" value="PJN07722"/>
        <property type="gene ID" value="CG723_32135"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033232">
        <property type="term" value="F:ABC-type D-methionine transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03258">
        <property type="entry name" value="ABC_MetN_methionine_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026253">
        <property type="entry name" value="ABC_MetN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041701">
        <property type="entry name" value="MetN_ABC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018449">
        <property type="entry name" value="NIL_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43166:SF5">
        <property type="entry name" value="PTHR43166:SF5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09383">
        <property type="entry name" value="NIL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00930">
        <property type="entry name" value="NIL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="SSF55021"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="4 6 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="7">
        <location>
            <begin position="7"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="43"/>
            <end position="50"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PJN07722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="353" mass="37707" checksum="F25CFE8131F52C27" modified="2018-04-25" version="1">MTESHVITTQGLTKVYRSRGREVTALDGVDLHVREGEVYGVIGQSGAGKSSLIRCVNLLERPTSGTVTVAGQDLTALVGRGSRAGKELREARSRIGMVFQHFNLLSSRTVQDNIELPLEILGKSGKERSRKALELLDLVGLADKAKSYPAQLSGGQKQRVGIARALAGDPKVLLSDEATSALDPETTRSILQLLRDLNQQLGLTVLLITHEMDVVKTVCDSAALMERGQIVESGTVSELLATPGSELAAALFPVSGDASGADRTVIDVTFHGESTTQPVISQMSRTYNIDISILGAAMDTVAGKQVGRMRIELPGRFDENVVPIGFLREQGLQVEIHGHQGGAPVLLKEGVTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JLS8</accession>
    <name>A0A2M9JLS8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Epimerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CG723_31030</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000017">
        <property type="protein sequence ID" value="PJN07841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN07841">
        <property type="protein sequence ID" value="PJN07841"/>
        <property type="gene ID" value="CG723_31030"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003719">
        <property type="entry name" value="Phenazine_PhzF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13774">
        <property type="entry name" value="PTHR13774"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02567">
        <property type="entry name" value="PhzC-PhzF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016184">
        <property type="entry name" value="PhzC_PhzF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00654">
        <property type="entry name" value="PhzF_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PJN07841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="285" mass="29957" checksum="AF5A7B7970374E50" modified="2018-04-25" version="1">MSEVAVVDACQRDGAGGSPTAVRDDVPFTDEERCRIPTELGTSHAVFLRATGIERRRPAYTLRFFTAQDELPACGHGTVAALAVLAEREGGDHDYRAVLRTAHRSFDGRASRNGDGLTASFDPGPVSLRSAGGPELRAVAGGLGLSEDAVAGDACVASNGRPRLLLPIRSRAALAELTPDLTLLRAACDRYGLLGCYAYSLPDRHGRAGARMFAPSIGVPEDIANANSTACLAAHAAGFGTYRLAVDMGDHLGSPSTITATVHRDRTGHRIRVGGQAAIVRTVMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JLV4</accession>
    <name>A0A2M9JLV4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_31155</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000017">
        <property type="protein sequence ID" value="PJN07860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN07860">
        <property type="protein sequence ID" value="PJN07860"/>
        <property type="gene ID" value="CG723_31155"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="29"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN07860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="95" mass="10586" checksum="E3823F447F59912B" modified="2018-04-25" version="1">MVHVREYVRADGTRVRAHSRWAAGARREMSVLAVIALVVVGFAGTTGSGSADGFNKQRPRPRSTAVYPVKFRDWDGLRPRPTPTVSYPIPWDRGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JMC0</accession>
    <name>A0A2M9JMC0_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Probable UbiX-like flavin prenyltransferase</fullName>
            <ecNumber evidence="5">2.5.1.129</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Phenolic acid decarboxylase subunit B</fullName>
            <shortName evidence="5">PAD</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CG723_30410</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CB01635</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Involved in the non-oxidative decarboxylation and detoxification of phenolic derivatives. Flavin prenyltransferase that catalyzes the synthesis of the prenylated FMN cofactor (prenyl-FMN) for phenolic acid decarboxylase.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>dimethylallyl phosphate + FMNH2 = phosphate + prenyl-FMNH2</text>
            <dbReference type="Rhea" id="RHEA:37743"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57618"/>
            <dbReference type="ChEBI" id="CHEBI:87467"/>
            <dbReference type="ChEBI" id="CHEBI:88052"/>
            <dbReference type="EC" id="2.5.1.129"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homododecamer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the UbiX/PAD1 family. YclB subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.129" evidence="5"/>
    <dbReference type="EMBL" id="NNBL01000016">
        <property type="protein sequence ID" value="PJN08009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08009">
        <property type="protein sequence ID" value="PJN08009"/>
        <property type="gene ID" value="CG723_30410"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106141">
        <property type="term" value="F:flavin prenyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019439">
        <property type="term" value="P:aromatic compound catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009636">
        <property type="term" value="P:response to toxic substance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1950">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01984">
        <property type="entry name" value="ubiX_pad"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01986">
        <property type="entry name" value="ubiX_pad_yclB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036551">
        <property type="entry name" value="Flavin_trans-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003382">
        <property type="entry name" value="Flavoprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004507">
        <property type="entry name" value="UbiX-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032901">
        <property type="entry name" value="UbiX_pad_YclB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43374">
        <property type="entry name" value="PTHR43374"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02441">
        <property type="entry name" value="Flavoprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52507">
        <property type="entry name" value="SSF52507"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00421">
        <property type="entry name" value="ubiX_pad"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0058">Aromatic hydrocarbons catabolism</keyword>
    <keyword evidence="5" id="KW-0216">Detoxification</keyword>
    <keyword evidence="2 5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3 5" id="KW-0288">FMN</keyword>
    <keyword evidence="1 5" id="KW-0637">Prenyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Flavoprotein" evidence="6">
        <location>
            <begin position="1"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="9"/>
            <end position="11"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="36"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="87"/>
            <end position="90"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="122"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PJN08009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="200" mass="21686" checksum="AF1E39FE4BF132E7" modified="2018-04-25" version="1">MRLVVGMTGATGAPFGVRLLENLRELPGVETHLVLSRWARTTIELETGLSVAEVSALADVTHHPEDQGATISSGSFRTDGMVIVPCSMKTLAGIRTGYAEGLVARAADVVLKERRRLVLVPRETPLNEIHLQNMLELARMGVQLVPPMPAFYNNPQTVDDIVDHVVARILDQFDLPAPAARRWAGMRAARAASRSFGDAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JMH6</accession>
    <name>A0A2M9JMH6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Iron-siderophore ABC transporter substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CG723_30790</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000016">
        <property type="protein sequence ID" value="PJN08070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08070">
        <property type="protein sequence ID" value="PJN08070"/>
        <property type="gene ID" value="CG723_30790"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002491">
        <property type="entry name" value="ABC_transptr_periplasmic_BD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01497">
        <property type="entry name" value="Peripla_BP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50983">
        <property type="entry name" value="FE_B12_PBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014760768" evidence="2">
        <location>
            <begin position="32"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="domain" description="Fe/B12 periplasmic-binding" evidence="3">
        <location>
            <begin position="90"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="23"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PJN08070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="348" mass="35729" checksum="7B6F6A4E25534334" modified="2018-04-25" version="1">MRAGGVKVVLAAAVVGGLLAGCSSSGGEGKAADKGGTGRNTVAGAADGKGPTAAPSAVPAGMASDAKDGAFPRTVGHYKGKADLKHAPKRIAVLSTGQLDDLLTLGTVPVASTRADNAGLVPDYLADAFPQDREKLGAMTDAGTRTAPNLESLARAKPDLILVNSSLGDLYPKLSAIAPTVVTKGQGINWKSDLLLVGAAVGKQEKAQQLLDGFAADTKRQGAGAKGAEVSMVRFSPGRTRMFGVSSFTGSIAVDMGLTRPKAQQFRAISQDIGAERIDTADGDWIFYSVQGKAAKTDAANVLAGPLWKSMQGVKARHAVQVDDDPWYLNAGPTAARLVLDELTEHLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JMK2</accession>
    <name>A0A2M9JMK2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Methylmalonyl-CoA mutase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CG723_30940</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CB01635</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>adenosylcob(III)alamin</name>
            <dbReference type="ChEBI" id="CHEBI:18408"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="2">Heterodimer of an alpha and a beta chain.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000016">
        <property type="protein sequence ID" value="PJN08095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08095">
        <property type="protein sequence ID" value="PJN08095"/>
        <property type="gene ID" value="CG723_30940"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031419">
        <property type="term" value="F:cobalamin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004494">
        <property type="term" value="F:methylmalonyl-CoA mutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016176">
        <property type="entry name" value="Cbl-dep_enz_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006099">
        <property type="entry name" value="MeMalonylCoA_mutase_a/b_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006098">
        <property type="entry name" value="MMCoA_mutase_a_cat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01642">
        <property type="entry name" value="MM_CoA_mutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51703">
        <property type="entry name" value="SSF51703"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00641">
        <property type="entry name" value="acid_CoA_mut_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="METMALONYL_COA_MUTASE" evidence="3">
        <location>
            <begin position="8"/>
            <end position="520"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PJN08095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="528" mass="58155" checksum="B3541D986AC6B55C" modified="2018-04-25" version="1">MGSEAQSESGLPIQPLYDGWSLTDFDADAKLGAPGEFPYTRGVYPSMYTGRPWTMRQYAGFGTAKESNERYHELVGAGTGGLSVAFDLPTQMGYDSDESIARGEVGKVGVAIDSIEDMRTLFQGLPLDKVSTSMTINAPGSTLLLLYQLVAAEQGIPGDQLTGTIQNDVLKEYIARGTYIFPPKQSLRLISDIFAYCHKELPRWNTISISGYHMAEAGATPAQEIAFTLANAKEYVRAALAAGLDVDDFAPRLSFFFVARTTLLEEIAKFRAARRIWARIMRDEFKAKNPKSQMLRFHTQTAGVQLTAQQPEVNLVRVALQGLGAVLGGTQSLHTNSYDEAIALPTQKAARLALRTQQVIAYETDVTKTVDPFAGSYVMESMTDDVEAAALELIQAVEDRGGAVAAIEQGFQKSEIEKSAYRIALEIDHEERTVVGVNKYALDEEEPYEPLRVDPQIEIDQCERLAALRKDRDNEAVERALEALRDAARGTDNVLPPMREALRLRATVGEVSHALRDVWGVHVPHDTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JNA1</accession>
    <name>A0A2M9JNA1_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Nucleoid-associated protein CG723_28555</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_28555</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Nucleoid</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the YbaB/EbfC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000014">
        <property type="protein sequence ID" value="PJN08341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08341">
        <property type="protein sequence ID" value="PJN08341"/>
        <property type="gene ID" value="CG723_28555"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043590">
        <property type="term" value="C:bacterial nucleoid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1310.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00274">
        <property type="entry name" value="DNA_YbaB_EbfC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036894">
        <property type="entry name" value="YbaB-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004401">
        <property type="entry name" value="YbaB/EbfC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33449">
        <property type="entry name" value="PTHR33449"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02575">
        <property type="entry name" value="YbaB_DNA_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004555">
        <property type="entry name" value="UCP004555"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82607">
        <property type="entry name" value="SSF82607"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00103">
        <property type="entry name" value="DNA_YbaB_EbfC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="10"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN08341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="113" mass="11525" checksum="5EA3A45275230E1E" modified="2018-04-25" version="1">MIPGGGQPNMQQLLQQAQKMQQDLAKAQEELALTEVEGQAGGGLVKATVTGSGELRGLVIDPKAVDPEDTETLADLVVAAVQAANENAQTLQQQKLGPLAQGLGGGGIPGLPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JNM8</accession>
    <name>A0A2M9JNM8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">1,2-phenylacetyl-CoA epoxidase subunit B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CG723_29305</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000014">
        <property type="protein sequence ID" value="PJN08470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08470">
        <property type="protein sequence ID" value="PJN08470"/>
        <property type="gene ID" value="CG723_29305"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.520">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009359">
        <property type="entry name" value="PaaB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038693">
        <property type="entry name" value="PaaB_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06243">
        <property type="entry name" value="PaaB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF030200">
        <property type="entry name" value="PaaB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02157">
        <property type="entry name" value="PA_CoA_Oxy2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PJN08470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="96" mass="10858" checksum="1229DC05239E4D93" modified="2018-04-25" version="1">MSDAKDWPLWEVFVRSRRGLSHTHAGSLHAPDAELALRNARDLYTRRGEGVSIWVVPSASITASSPDEKDPFFEPSADKPYRHPTFYEIPEGVKHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-09-29" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JNN5</accession>
    <name>A0A2M9JNN5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Secretion protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_28095</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GSP E family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000014">
        <property type="protein sequence ID" value="PJN08476.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08476">
        <property type="protein sequence ID" value="PJN08476"/>
        <property type="gene ID" value="CG723_28095"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022399">
        <property type="entry name" value="HlxAse/secretion_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001482">
        <property type="entry name" value="T2SS/T4SS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00437">
        <property type="entry name" value="T2SSE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03819">
        <property type="entry name" value="heli_sec_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="T2SP_E" evidence="2">
        <location>
            <begin position="53"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006611"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN08476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="381" mass="40203" checksum="9CF2CF7E4EA67556" modified="2018-04-25" version="1">MLDGVRQWLAENGAEATPARVAEALRAQGKLLGDAEVLGAAGKLRSELVGTGPLEPLLADPSVTDVLVSAPDRVWVDRGGGLELTGVSFESTSSVRRLAQRLAAVAGRRLDDARPWVDARLPDGTRLHAVLPPVAVGCACLSLRVVRPRAFTLEELVTAGTVPPGGDRVLRALLDARLSFLISGGTGSGKTTLLSALLGLVGPGERVVLAEDSAELRPDHPHVVRLEARPVNQEGAGLVALDDLVRQALRMRPDRLVVGEVRGPEVVALLAALNTGHEGGCGTVHANAAHDVPARLEALGTAAGLDRGALHSQLAAALSVVLHLVRDRRGRRRIAEVHVLERDAAGWVVTVPALRWGEGEFVRERGWGRLRGLLGEFMEGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-05-25" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JNQ4</accession>
    <name>A0A2M9JNQ4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Phosphoribosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_28890</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000014">
        <property type="protein sequence ID" value="PJN08498.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08498">
        <property type="protein sequence ID" value="PJN08498"/>
        <property type="gene ID" value="CG723_28890"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRibTrfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00156">
        <property type="entry name" value="Pribosyltran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="SSF53271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pribosyltran" evidence="1">
        <location>
            <begin position="12"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN08498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="169" mass="18744" checksum="756085A8E6C1792F" modified="2018-04-25" version="1">MSDVRENLTYEKFGVAVRELAQTIADDGYEPDIVLSIARGGVFVAGGLAYALDCKNIHLVNVEFYTGVGTTLEMPVMLAPVPNAIDFSDKKVLITDDVADTGKTLKLVHDFCLDTVAEVRSAVIYEKSHSLVKCEYVWKRTDEWINFPWSVLPPVHRSGEAPKENLEAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JNU1</accession>
    <name>A0A2M9JNU1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CG723_27535</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CB01635</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000013">
        <property type="protein sequence ID" value="PJN08534.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08534">
        <property type="protein sequence ID" value="PJN08534"/>
        <property type="gene ID" value="CG723_27535"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002397">
        <property type="entry name" value="Cyt_P450_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00359">
        <property type="entry name" value="BP450"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="SSF48264"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0349">Heme</keyword>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="64"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PJN08534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="399" mass="44300" checksum="2669165A0F7853B9" modified="2018-04-25" version="1">MSATRRVHIYPFEGEVDGLEIHPKFAELRETDPLARVRLPYGGEGWMVTRYDDVRAANSDPRFSRAQIGEDTPRTTPLARRSDTILSLDPPEHTRLRRLLSKAFTARRMGAMQSWLEELFTGLLDGVERTGHPADIVRDLAQPFTIAVICRLLGVPYEDRGRFQHWSEVIMSTTAYSKEEAMSADASIRAYLADLVSARRAAPHDDLLGVLVSARDDDDRLTEDELITFGVTLLVAGHETSAHQLGNMVYALLTHEDQLSLLREQPELLPRAVEELLRFVPLGNGVGNARIALEDVELSGGTVRAGEGVVAAAVNANRDPRAFDDPDRLDITREKNPHLAFGHGAHYCLGAQLARMELRVAIGGLLERFPGLRLAVPADQVEWKTGGLFRGPQRLPIAW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JNU4</accession>
    <name>A0A2M9JNU4_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">SHMT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CG723_27555</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CB01635</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SHMT family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000013">
        <property type="protein sequence ID" value="PJN08538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08538">
        <property type="protein sequence ID" value="PJN08538"/>
        <property type="gene ID" value="CG723_27555"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004372">
        <property type="term" value="F:glycine hydroxymethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019264">
        <property type="term" value="P:glycine biosynthetic process from serine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035999">
        <property type="term" value="P:tetrahydrofolate interconversion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001085">
        <property type="entry name" value="Ser_HO-MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039429">
        <property type="entry name" value="SHMT-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11680">
        <property type="entry name" value="PTHR11680"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00464">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000412">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SHMT" evidence="6">
        <location>
            <begin position="84"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="5">
        <location>
            <position position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000412-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PJN08538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="447" mass="47939" checksum="68209837D3B89899" modified="2018-04-25" version="1">MRTADLTLDTVVRLLSENEASARQTLSMVPSETSMSGLAKLPMLLDPYHRYFFNEGDDPDRWHFRGAQRLRDLEMELTIPLLQELGRASYASVRPLSGLNGMTLVLGALGGEPGSTVVTVSPEQGGHYATPQVAARLGLDVEFLRGPDPHSLDLEHAAELLARVRPSLVYVDQSHCLFPVDVKSLVETVREASPGTLVHVDASHWLGLVLADAFPNPLDQGADSWGGSTHKTFPGPQKAVVLTRDPQVEQLIRDAQDFLISNHHFAATIALGISLLEFREFGPAYTRAVLEHTGRFGRLLTERGLTVVAADRGYSAGHQLWLDTEADGIAPKDAAARLSAASLKVNFMAGLPGFTGQGVRIGLNEATYQGLSGDDIDELADIFVAAVRDTEPAALLAERTAALRTRTPFGACAADGSPLLATALDLCEGALRRTGAAAGRPLTEASR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JP06</accession>
    <name>A0A2M9JP06_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GNAT family N-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_28055</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000013">
        <property type="protein sequence ID" value="PJN08613.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08613">
        <property type="protein sequence ID" value="PJN08613"/>
        <property type="gene ID" value="CG723_28055"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="4"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN08613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="158" mass="18015" checksum="964EDB23D6C9DB1F" modified="2018-04-25" version="1">MTAVGLRPATAADSEYCFQLHKAAMGTHITATWGWDEQVQRGFHIRAFSPGRWQIIIVDSADAGVLHVEHRPNEIYLARIELHPDYQQRGIGSQLIRTLLQQAREQGQVLTLDVLTVNQRAQDLYRRMGLDEVARHGENNIKIRMSSRIPQSDPIHRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JPM9</accession>
    <name>A0A2M9JPM9_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA helicase</fullName>
            <ecNumber evidence="2">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CG723_25310</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CB01635</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O = ADP + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="2"/>
    <dbReference type="EMBL" id="NNBL01000011">
        <property type="protein sequence ID" value="PJN08824.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08824">
        <property type="protein sequence ID" value="PJN08824"/>
        <property type="gene ID" value="CG723_25310"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000212">
        <property type="entry name" value="DNA_helicase_UvrD/REP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014016">
        <property type="entry name" value="UvrD-like_ATP-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11070">
        <property type="entry name" value="PTHR11070"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51198">
        <property type="entry name" value="UVRD_HELICASE_ATP_BIND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 7" id="KW-0347">Helicase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UvrD-like helicase ATP-binding" evidence="6">
        <location>
            <begin position="178"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="199"/>
            <end position="206"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PJN08824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="753" mass="81498" checksum="28B866B995ED4CAD" modified="2018-04-25" version="1">MQKEQEFIDRLYARVDVLRGDAAESVSDALTPVGTGQQARLERDLLVVERSGLLAALNAVDGSLCFGRIDLTEKAGGTTHHIGRIGIREDDSEHTPILIDWRAPVARPFYLATGHTPMGIRRRRHLTTEGRTVTELHDEILDLDDEERTGFEDPTGDAVLLAALNSARTGRMGDIVQTIQAEQDRIIRHSHRGVLVVEGGPGTGKTAVALHRAAFLLYEQRELLAKRAVLIVGPNPAFLGYIGEVLPALGETGVLLASLGELFPGVHATAEDTPHAAAVKGAEAMVDALALAVRDRQQLPEPGAPLIVRHDDGDLILDWEIAYEARQAGRDTLLPHNLARPHFAFRIIDALTAQLAERIGADPYGGPNFLGPDDLAQIGKGVAASAEVHAAIEELWPRLTPQDLVADFLAEPVHLAGEDAKAIRRDVTGPADWTPADVPLLDEAAELIGVDDSAERALAEAARQERIAYAQGVLELSRGSETYEFEDEEDSEVLAAHDIVDAERVADWYEEEDHRSAAERAAADRTWAFGHIIVDEAQELSPMAWRLLMRRSPTRSMTLVGDPAQTAEEAGVGSWEKILAPYVADRWEHTRLGVNYRTPSEIMDVAAAVLRAEHPGFEPPSSVRSTGVRPWARAAGDVVKAVAEEAVAATPEEGRLAVIAPRRLHAALAAVLPDVVAGGEPDLTKHLVLLDPRQAKGLEFDRVLVVEPGEYGVSDLYVALTRATQTLGVLHGGELPESLRGVLRTVPGSPDRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JPR0</accession>
    <name>A0A2M9JPR0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CG723_25470</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000011">
        <property type="protein sequence ID" value="PJN08850.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08850">
        <property type="protein sequence ID" value="PJN08850"/>
        <property type="gene ID" value="CG723_25470"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.160.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002838">
        <property type="entry name" value="AIM24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036983">
        <property type="entry name" value="AIM24_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016031">
        <property type="entry name" value="Trp_RNA-bd_attenuator-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01987">
        <property type="entry name" value="AIM24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51219">
        <property type="entry name" value="SSF51219"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PJN08850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="212" mass="22511" checksum="44C3954ADA3A5B5E" modified="2018-04-25" version="1">MATFRLQGSRVLAVDMTGDSVKAKNGSMVAYDGRMAFKKMTGGGEGVRGMVTRRLTGEEMTVMEVKGQGTCWFADRAGEISVVNLRGDKLFVESSNLLCTDAGLRTGTSFTGVRGASQGNGLFTTIVEGHGQAAIMSEGPAVVLRVSRDHPLTVDPGAYVAHQGNVRQSFQSGVTFRTFMGEGGGEAFQIRFEGDGLVYVQPSERNTIAGDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JPY9</accession>
    <name>A0A2M9JPY9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">DNA-binding response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CG723_25975</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000011">
        <property type="protein sequence ID" value="PJN08934.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08934">
        <property type="protein sequence ID" value="PJN08934"/>
        <property type="gene ID" value="CG723_25975"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00383">
        <property type="entry name" value="trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3 7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="5">
        <location>
            <begin position="20"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="domain" description="OmpR/PhoB-type" evidence="6">
        <location>
            <begin position="148"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="3">
        <location>
            <begin position="148"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PJN08934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="245" mass="26991" checksum="2A3ACA97D7705E53" modified="2018-04-25" version="1">MEQTHTSHNGTTATPGAQRRVLVVEDDPTIVDAIAARLRAEGFLVQTAQDGPAAVDTAEAWQPDLLILDIMLPGFDGLEVCRRVQAQRPVPVMMLTARDDETDMLVGLGVGADDYMTKPFSMRELAARVHVLLRRVERAALAAATPRSGILRLGELEIDHAQRRVRVRSEDVHLTPTEFDLLVCLANTPRAVLSREQLLAEVWDWADASGTRTVDSHIKALRRKIGAERIRTVHGVGYALETPTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-05-25" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JQ01</accession>
    <name>A0A2M9JQ01_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Zn-dependent oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_26010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000011">
        <property type="protein sequence ID" value="PJN08940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08940">
        <property type="protein sequence ID" value="PJN08940"/>
        <property type="gene ID" value="CG723_26010"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="PKS_ER"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PKS_ER" evidence="1">
        <location>
            <begin position="13"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN08940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="320" mass="33914" checksum="FA073FE3F9593CBA" modified="2018-04-25" version="1">MFAAYAARIDRDQPLNGLELGDRPAPEARPGWTTVNVKAASLNHHDLWSLRGVGLGEDKLPMILGCDAAGIDQDGNEVVLHSVIGQAGYGVGPREGRSILTEKYQGTFAEQVTVPEWNVLPKPKELSFEEAACLPTAWLTAYRMLFTNAGVRPGDSVLVQGAGGGVATAAIVLGKAAGLKVFATSRDEAKRKRALELGAVEAVESGARLPQRVDAVIETVGAATWSHSIKSLKPGGTVVISGATSGDRPSHAELTRVFFLELKIVGSTMGSKDELEDLLSFCAATGVRPVIDETLPLDRAREGFERMEAGGQFGKIVLTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JQ51</accession>
    <name>A0A2M9JQ51_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_26245</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000011">
        <property type="protein sequence ID" value="PJN08986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08986">
        <property type="protein sequence ID" value="PJN08986"/>
        <property type="gene ID" value="CG723_26245"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002403">
        <property type="entry name" value="Cyt_P450_E_grp-IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00465">
        <property type="entry name" value="EP450IV"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="SSF48264"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0349">Heme</keyword>
    <keyword evidence="1" id="KW-0408">Iron</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN08986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="459" mass="50322" checksum="4C8BF2221172790B" modified="2018-04-25" version="1">MTVESAESSVPAVAEPGERRTPPYAGGGAPLLGHAWNLVRDPLAFVASLRGHGDLVRLRLGPKTAYAVCDPDLVATLLKSPDYMVGGPLWDTLGVLLGKGVATSNGPMHRRQRRTIQPAFRTDRIADHATVMEEEARAMAARWKPGETVDIGAEVFRTAVRIVARSVLHVDSVDERADRLSSSLHTVFSGLYRRMVLSVGPFYRLPLPANRRFERALADLHRLVDEIIAERRASGVNPGDLLAALLGAEDENGETVGEQEVHDQVVSLVVAGAENVASTLTWTFQLLAEHPEQESRLHEEVESVTAGRPVAFADLKGLIHTRNVITEAMRIRPAVWILTRQAAVDTELGGYHIPAGADIVYSPYAMQRDPRSFPDHLEFDPDRWLPERAAESRQSAMMPFSVGNRKCPGDHFSMAELAIILATVTPRWRLVPAAETDSTARVGITLQPKRALLRVEGRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JQA3</accession>
    <name>A0A2M9JQA3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Phosphate ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CG723_24270</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000010">
        <property type="protein sequence ID" value="PJN09050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN09050">
        <property type="protein sequence ID" value="PJN09050"/>
        <property type="gene ID" value="CG723_24270"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015415">
        <property type="term" value="F:ATPase-coupled phosphate ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005315">
        <property type="term" value="F:inorganic phosphate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03260">
        <property type="entry name" value="ABC_PstB_phosphate_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005670">
        <property type="entry name" value="Phosp_transpt1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43423">
        <property type="entry name" value="PTHR43423"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00972">
        <property type="entry name" value="3a0107s01c2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="5"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="37"/>
            <end position="44"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PJN09050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="258" mass="28169" checksum="3395AFB93C0473FA" modified="2018-04-25" version="1">MAKRIDVSGLTAYYGSHKAIEDISMTVEPRSVTAFIGPSGCGKSTFLRTLNRMHEVTPGGRVEGKVLLDDEDLYGTHVDPVAVRRTVGMVFQRPNPFPTMSIFDNVAAGLRLNGSYKKSELGDVVEKSLKGANLWNEVKDRLNKPGSGLSGGQQQRLCIARAIAVEPQVLLMDEPCSALDPISTLAIEDLIGELKERFTIVIVTHNMQQAARVSDRTAFFNLSAVGQPGKLVEIDETERIFSNPSVQATEDYISGRFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JQB0</accession>
    <name>A0A2M9JQB0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CG723_24250</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000010">
        <property type="protein sequence ID" value="PJN09046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN09046">
        <property type="protein sequence ID" value="PJN09046"/>
        <property type="gene ID" value="CG723_24250"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PJN09046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="63" mass="6815" checksum="8AAADA94A2EEA844" modified="2018-04-25" version="1">MNVAPVGGTAVHDHVALAEIELCGELIIAASAADEDRLSADRIDEVLRVAEERWPRGEGFRES</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JQZ3</accession>
    <name>A0A2M9JQZ3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Acyl-CoA synthetase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CG723_23265</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000009">
        <property type="protein sequence ID" value="PJN09274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN09274">
        <property type="protein sequence ID" value="PJN09274"/>
        <property type="gene ID" value="CG723_23265"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="204"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding" evidence="3">
        <location>
            <begin position="9"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding_C" evidence="4">
        <location>
            <begin position="411"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="304"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="307"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PJN09274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="508" mass="53312" checksum="7B9E70243815AF3F" modified="2018-04-25" version="1">MRQVVQEFQRQAEQADFVAVIDDSSSHTARELLAEAGRLASALSAGAGDGSGGTVMLQADNSWRTVAGTLAVGLGDGVLAVVNRHTTRAEFAAAFEDIRPDAVVAEPSAMDEWGVSELMTGGAGAAFTSDPVLDGWTCHAAPGQRDVSRWSGGVLIGLTSGSTGRPKGVVQSEDALRYAGTSTIEINGLTRGDAVAAIVPLSSTAAYCFGVYLALLLGGPLVLMTKWDRAVALQRMAEAQVRWTMCVPTMALQMGAEAAGSGILGGVRAITVGGGPMDRGALARAEQSLGTRILRVFGMSECLGHTSPRPDEPEEIRLGRDGRPFPGTDLRALTPEGDTAGPGVSGRAQVRGPSLFLGYARDGKVEAPTLTEDGYFPTGDLLMTHDDGTISIMGREKDIIIRGGRNIDITEIERAVASYPRVARACVAAVPDEVLGERIALLVVTEDGGGIDLAEVTGHLDSVGLSRTKWPEFVYGIEELPQTKVGKLDRSGARELAHRLRTNTPDPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JR07</accession>
    <name>A0A2M9JR07_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Acyl-CoA dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_23250</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000009">
        <property type="protein sequence ID" value="PJN09272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN09272">
        <property type="protein sequence ID" value="PJN09272"/>
        <property type="gene ID" value="CG723_23250"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd05154">
        <property type="entry name" value="ACAD10_11_N-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041726">
        <property type="entry name" value="ACAD10_11_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="APH" evidence="1">
        <location>
            <begin position="35"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN09272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="342" mass="36721" checksum="BE74B13104D699A4" modified="2018-04-25" version="1">MTTSEEAVIGVDVPALRRYFERHVPDFTGELRIALLQGGRSNLTYDVTDGTHRWVLRRPPLGVLTPTAHDMDREYRVVAALGGTGVPVARAELSCTDSDVIGAPFCVVDFVEGPVLRDGDRAAELPPSDARRAAEALVDALAALHSVDAAAVGLGDFGRPDGYLERQVRRWRGQWDKVATRTLPDVDELHGRLARALPASGAPTIVHGDYRLDNTILAPGDFGRIAAIVDWEMATLGDPLADLGMLLMYWDATCEPVLGARHVPTANPGFPSGQDLAERYAAKSGRDVRSLSYYQALACFKLAVIAEGIHARYAAGQTVGTGFERVGSAVPALLNSGLELLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JRB1</accession>
    <name>A0A2M9JRB1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CG723_24140</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000009">
        <property type="protein sequence ID" value="PJN09415.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN09415">
        <property type="protein sequence ID" value="PJN09415"/>
        <property type="gene ID" value="CG723_24140"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PJN09415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="137" mass="15038" checksum="8DD04CA2F3B15735" modified="2018-04-25" version="1">MLAEGYEVTYRALTGRDLLAVDPASSEARRTLLNRCVVDTTPATDDLPQGVLETVAQRLADLDPGADTVLPITCPYCRHAWTAALDVADYLWAEVEGYARRLLHEVHTLACVYGWSESEVLAVSPARRRFYLAATAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JRH5</accession>
    <name>A0A2M9JRH5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_22270</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000008">
        <property type="protein sequence ID" value="PJN09490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN09490">
        <property type="protein sequence ID" value="PJN09490"/>
        <property type="gene ID" value="CG723_22270"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025363">
        <property type="entry name" value="DUF4267"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14087">
        <property type="entry name" value="DUF4267"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="48"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="98"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN09490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="120" mass="12303" checksum="7D539918EDC7E945" modified="2018-04-25" version="1">MCSPALLGAALIFMGGRAFTTPQATVGFGIPDTPADDPASRPWLRVKGLREIACGVFVFVFVLMLVATTIPLGWYVMALAAIPAGDAVVVLRSGGPKAAAYGIHGASAVVMLMTSIGLLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JRT5</accession>
    <name>A0A2M9JRT5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_22935</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000008">
        <property type="protein sequence ID" value="PJN09591.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN09591">
        <property type="protein sequence ID" value="PJN09591"/>
        <property type="gene ID" value="CG723_22935"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014741145" evidence="1">
        <location>
            <begin position="25"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN09591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="149" mass="15289" checksum="AD53C4DF1D4A21B2" modified="2018-04-25" version="1">MRHIGTILGAAALTVLTIPANAQATAVACGGGVSTGRVAVNGCISAQRGKEGRIYTREITAHVKARNTGPRAANLSYEAFFRVVDGGHWVKLGSGRTYVPAGGTVEPTEVGSSTRVCAPGVKVEIRVHARADGAAWSGWSTAGTAQCQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JRZ6</accession>
    <name>A0A2M9JRZ6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Long-chain-fatty-acid--CoA ligase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_22000</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000008">
        <property type="protein sequence ID" value="PJN09622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN09622">
        <property type="protein sequence ID" value="PJN09622"/>
        <property type="gene ID" value="CG723_22000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-binding" evidence="1">
        <location>
            <begin position="9"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding_C" evidence="2">
        <location>
            <begin position="410"/>
            <end position="485"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN09622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="500" mass="53764" checksum="240B6DAC9742D9A0" modified="2018-04-25" version="1">MNLASHVVRSASAYPHRAALRLRDDILSYRALDQVSARMAGLLRDRGVKPGDQVAIMLPNSPEFAIAYFGVLRAGGIVVPMNPLLKSREVAFYLRDSGARLLFARPAFADEVRTGAQQVGADAVVVDPGGFDTLLASAPLAEDVIERHEDDTAVILYTSGTTGQPKGAELTHANLTRNCEVVAAELLHLTSDDVIFGGLPLFHAFGQSCTLNAAVTAGACLTLLPRFDAEQALRMLAEHGVTVFAGVPTIFSRLLQPLDRDAYDVSALRLAVCGGAAIPVQVLRDFEAAFGCVVLEGYGLSETSPVASFSRLDARRKPGSIGTPIHGVQMRVVDNSGNEVSQGETGEIAIRGHNVMKGYWQRPEATAAAIRNGWFHTGDLGRVDEDGYFWIVGRETDLIIRGGYNVYPREVEDVLYEHPAVAEAAVIGLPNPDLGEEVGAAVVLKPGAAATAHELRDYVKRQVAAYKYPRKVWIVDALPKGSTGKILKREIVPPSEPGDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-09-29" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JS39</accession>
    <name>A0A2M9JS39_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Cytosine permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CG723_20850</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CB01635</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the purine-cytosine permease (2.A.39) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000007">
        <property type="protein sequence ID" value="PJN09663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN09663">
        <property type="protein sequence ID" value="PJN09663"/>
        <property type="gene ID" value="CG723_20850"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001248">
        <property type="entry name" value="Pur-cyt_permease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026030">
        <property type="entry name" value="Pur-cyt_permease_Fcy2/21/22"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31806">
        <property type="entry name" value="PTHR31806"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02133">
        <property type="entry name" value="Transp_cyt_pur"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002744">
        <property type="entry name" value="Pur-cyt_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="23"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="50"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="96"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="136"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="166"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="206"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="247"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="286"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="327"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="352"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="408"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="432"/>
            <end position="455"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR002744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PJN09663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="483" mass="50375" checksum="F9B8B6079BA2500D" modified="2018-04-25" version="1">MAIEQRGVDTIPDEERTSGPRDIVSILLGSNLCLGVIVFGWLPVSFGLGWWASVTSVVAGTLLGTALTAPLALVSLRTGTNLSTSSGAQFGVRGRLVGSVVGLLLSLGYTALTVWIGGDAMTGVLHRLFGVPESGLTYGIVYALLAAATVIGAVYGYRVLLRLSRVLAVGMTALLALGVVAYAPHFTTAPLPDAGGYLLGSFWPTWLLALVAAGLSGPIAFITLLGDYTRYVSPARHSQRSVLRATWLGLIVGLLTPQLFGTFTAYAARAALDYAGSLVSASPTWYLIPLLLAASAGSVGNAGLMLYSMGLDLDAILPRASRTAATYTVAAVATVCVFVGHFAWAAQDAMTSFVLLLTAIGTPWAVITLIGFVRCRGVYDADALQVFNRRSRGGVYWYRNGWNPRATVSWALGAFVGLLAVSLPSYEGPLLSLTGGVDCSFLLSGLVGGAAYLALTAREVRSVRVRAAADKKSEAALVTSGEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JS73</accession>
    <name>A0A2M9JS73_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Signal recognition particle protein</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Fifty-four homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">ffh</name>
        <name evidence="12" type="ORF">CG723_21215</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">CB01635</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
        <text evidence="7">The SRP-RNC complex is targeted to the cytoplasmic membrane.</text>
    </comment>
    <comment type="domain">
        <text evidence="7">Composed of three domains: the N-terminal N domain, which is responsible for interactions with the ribosome, the central G domain, which binds GTP, and the C-terminal M domain, which binds the RNA and the signal sequence of the RNC.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the GTP-binding SRP family. SRP54 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000007">
        <property type="protein sequence ID" value="PJN09725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN09725">
        <property type="protein sequence ID" value="PJN09725"/>
        <property type="gene ID" value="CG723_21215"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048500">
        <property type="term" value="C:signal recognition particle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008312">
        <property type="term" value="F:7S RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006614">
        <property type="term" value="P:SRP-dependent cotranslational protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00306">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036891">
        <property type="entry name" value="Signal_recog_part_SRP54_M_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013822">
        <property type="entry name" value="Signal_recog_particl_SRP54_hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004125">
        <property type="entry name" value="Signal_recog_particle_SRP54_M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004780">
        <property type="entry name" value="SRP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022941">
        <property type="entry name" value="SRP54"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000897">
        <property type="entry name" value="SRP54_GTPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042101">
        <property type="entry name" value="SRP54_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11564">
        <property type="entry name" value="PTHR11564"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11564:SF7">
        <property type="entry name" value="PTHR11564:SF7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00448">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02881">
        <property type="entry name" value="SRP54_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02978">
        <property type="entry name" value="SRP_SPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00962">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00963">
        <property type="entry name" value="SRP54_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47446">
        <property type="entry name" value="SSF47446"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00959">
        <property type="entry name" value="ffh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 7" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5 7" id="KW-0733">Signal recognition particle</keyword>
    <feature type="domain" description="SRP54_N" evidence="11">
        <location>
            <begin position="1"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="domain" description="AAA" evidence="9">
        <location>
            <begin position="99"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="domain" description="SRP54" evidence="10">
        <location>
            <begin position="100"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="434"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="456"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="471"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="107"/>
            <end position="114"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="192"/>
            <end position="196"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="250"/>
            <end position="253"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PJN09725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="517" mass="55700" checksum="F9D7A5F836B92494" modified="2018-04-25" version="1">MFDTLSDRLAATFKNLRGKGRLSEADIDATAREIRIALLEADVALPVVRAFIKQVKERAAGAEVSQALNPAQQVIKIVNEELIGILGGETRRLRFAKNPPTVIMLAGLQGAGKTTLAGKLGHWLKGQGHAPLLVACDLQRPNAVNQLSVVAERAGVGIYAPEPGNGVGDPVQVAKDSVEFARQKQYDVVIVDTAGRLGIDQELMQQAADIRDAVSPDEVLFVVDAMIGQDAVNTAEAFRDGVGFDGVVLSKLDGDARGGAALSIAHVTGRQVMFASNGEKLDDFDAFHPDRMASRILGMGDMLTLIEKAEQTFSQQEAEKMASKLASKKGQDFTLDDFLAQMEQVRKMGSISKLLGMLPGMAQMKDQINNLDERDVDRTAAIIKSMTPAERADATIINGSRRARIARGSGVEVSAVKNLVERFFEARKMMSRMAQGGGMPGMPGMPGMGGGPGRQKKKQKQAKGKQRSGNPMKRKQQEEEEAARREAAGQSGNAFGLPAGEQDKNFELPDEFKKFMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JSC9</accession>
    <name>A0A2M9JSC9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CG723_21595</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CB01635</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000007">
        <property type="protein sequence ID" value="PJN09791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN09791">
        <property type="protein sequence ID" value="PJN09791"/>
        <property type="gene ID" value="CG723_21595"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="7"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="68"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="104"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="129"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="187"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="230"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="66"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PJN09791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="272" mass="28053" checksum="CDDB205EF3BEF5DD" modified="2018-04-25" version="1">MKRSATLWTGGVLAGLIALVALVSLFWLPYDPSDTSGGRLAGPGDGHLIGTDKLGRDLLTQLMAGSRIAIAAGLGSVVIAAVVGITLGLIAAFAQGWFDDTVSALLDILIAFPTLLLAMLIVSARSATLTSAVLAIGIAQSAIVARLTRILAKRVLAQDYITASRTSGTSWPRIVGAHVLPNIWPTLVVNLALQFGLAVLAEASLSYLGLGAPPPNASWGRMLQEAQATFTTAPAGALAPGILLVLLVIGVNLVADGLRDTLDPARRRRTAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JSE7</accession>
    <name>A0A2M9JSE7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CG723_21620</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000007">
        <property type="protein sequence ID" value="PJN09796.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN09796">
        <property type="protein sequence ID" value="PJN09796"/>
        <property type="gene ID" value="CG723_21620"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016773">
        <property type="term" value="F:phosphotransferase activity, alcohol group as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019748">
        <property type="term" value="P:secondary metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006748">
        <property type="entry name" value="NH2Glyco/OHUrea_AB-resist_kin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04655">
        <property type="entry name" value="APH_6_hur"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PJN09796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="297" mass="32487" checksum="3F116C6ACF7F1A8F" modified="2018-04-25" version="1">MSFEPPKRLVNALGEVRDDGASAWLARVPEILQEAVERLELTVERVHVPGGRSSLVVLVRRADGTPAVLKLAPERFRPEAEHAALTHWNGLGAVQLLGDGGDLLLERLHPEVSVRSLPEAKALLEAAGTLRRLWVEPPSWRSCETVADRTGRQAAAMRATAAAEPDVVPLVDAALTARDELLVAPPELRLLHGTFRQSKVLAGERTPWLAVGPDPVVGECAFDLARLVRDRVEDLIASPSGAATTRRRVKRLAESLDVDQERLRGWTLFRAVESGVRALRVGRGRDAELLLEFAGWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JSF8</accession>
    <name>A0A2M9JSF8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Type VII secretion protein EccE</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">eccE</name>
        <name evidence="6" type="ORF">CG723_21715</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CB01635</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the EccE family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000007">
        <property type="protein sequence ID" value="PJN09814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN09814">
        <property type="protein sequence ID" value="PJN09814"/>
        <property type="gene ID" value="CG723_21715"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021368">
        <property type="entry name" value="T7SS_EccE"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11203">
        <property type="entry name" value="EccE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03923">
        <property type="entry name" value="T7SS_EccE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="3 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="60"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="85"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PJN09814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="453" mass="47706" checksum="7C09CDCB2A6E5F5C" modified="2018-04-25" version="1">MASATRTRSRSQSRSRSGGRPGPGDGAPSARSGGGAGSPAAPAGPVSLHLKSRSGRAGSFRLQQMVMIEVAAALVVGAAVVDKLALVPAGVVAVILVLFALVRRRGRSLPEWLGTVLALRGRKRRAASTPVPPGTEPGLAPAVECDPSLRTYSYSRGDDRDQRPIGMVGDGGFLTAVLQVESDATALRAERSRRPLPIGIVRDALDVDGILLESAQIVLHTQPAPALHLPQQSVAVSNYAPLQAQTGSPAVRITWIALKLDPELCPEAVAARGGGTVGAQKCVARAAQHLASRLTGAGFRASVLTEEELTAAVATSACANPMVTAQAGRSELPQRRTEESSRSWRCDNRRHTTYWVRRWPQLGGSGPALHQLVALLTTVPALATTFSLTLSRGDQRDIQLCGHMRITGRSESELTTARRSLETAARQAKTGLVRLDREQLPGVLATLPLGGAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-06-02" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JSH4</accession>
    <name>A0A2M9JSH4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_21770</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000007">
        <property type="protein sequence ID" value="PJN09824.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN09824">
        <property type="protein sequence ID" value="PJN09824"/>
        <property type="gene ID" value="CG723_21770"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="142"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="144"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN09824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="167" mass="18412" checksum="4BB64C4D0CD4F074" modified="2018-04-25" version="1">MAWDEWEQLKSEAAGRQSTQMQLNRVPDDEGGGPPPSQYGDLAVGHGDLEKVGSDAHKLYSQMWDKARVAVPSSDSAASDLTKQGFALGGGLQEVSNRWEEQLRSLMDATAQIANHMHRTKKLHGADEDFIQRQMSSIDMLDAGFDERVGDPGKKNPVYGEPKKEDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JSI1</accession>
    <name>A0A2M9JSI1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Dynein regulation protein LC7</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_20970</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000007">
        <property type="protein sequence ID" value="PJN09851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067164664.1">
        <property type="nucleotide sequence ID" value="NZ_NNBL01000007.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN09851">
        <property type="protein sequence ID" value="PJN09851"/>
        <property type="gene ID" value="CG723_20970"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004942">
        <property type="entry name" value="Roadblock/LAMTOR2_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03259">
        <property type="entry name" value="Robl_LC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00960">
        <property type="entry name" value="Robl_LC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Robl_LC7" evidence="1">
        <location>
            <begin position="9"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN09851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="137" mass="14331" checksum="83B95396ACDA8376" modified="2018-04-25" version="1">MSQAAQNLNWLITNFVDNTPGVSHTVVVSADGLLLAMSEGFPRDRADQLAAVASGLTSLTAGASRIFEGGTVAQTVVEMERGFLFLMSVSDGSSLAVLAHPECDIGLVGYEMALLVDRAGSVLTPDLRAELQGSLLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JT11</accession>
    <name>A0A2M9JT11_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">LysR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_20015</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LysR transcriptional regulatory family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000006">
        <property type="protein sequence ID" value="PJN10009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN10009">
        <property type="protein sequence ID" value="PJN10009"/>
        <property type="gene ID" value="CG723_20015"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005119">
        <property type="entry name" value="LysR_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000847">
        <property type="entry name" value="Tscrpt_reg_HTH_LysR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00126">
        <property type="entry name" value="HTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03466">
        <property type="entry name" value="LysR_substrate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00039">
        <property type="entry name" value="HTHLYSR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50931">
        <property type="entry name" value="HTH_LYSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH lysR-type" evidence="2">
        <location>
            <begin position="2"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN10009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="316" mass="33053" checksum="D924F2943660C35E" modified="2018-04-25" version="1">MIEARHLRVLRAVAATGSFSAAARELGCTQPAVSQQMKALESSAGTPLLIRTGREMRLTQAGEALVRHAAGILAGLTAAEEEVAAIAGLRAGRVRLVSFPSGSSTLVPTALAALRAAHPGTRVSLVEAEPPRSVEMLREGDCDVALAFRYEGRREASQDKAGGGRRVGEGAQAAEDWDDLVVRPLLADRLVGLVPEGHRLAKSDAVSIGELADEPWIAGCPRCRRQLVEVCEGAGFTPRIDFATDDYPAVIGLVGAGLGVAVLPELAIESVRPKGARTVTVEPAVQREIVALTLPDLAQVPAVAATLDHLARAAAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JT61</accession>
    <name>A0A2M9JT61_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 7 9">50S ribosomal protein L23</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">rplW</name>
        <name evidence="11" type="ORF">CG723_20320</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CB01635</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Part of the 50S ribosomal subunit. Contacts protein L29, and trigger factor when it is bound to the ribosome.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7 8">Belongs to the universal ribosomal protein uL23 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000006">
        <property type="protein sequence ID" value="PJN10064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN10064">
        <property type="protein sequence ID" value="PJN10064"/>
        <property type="gene ID" value="CG723_20320"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01369_B">
        <property type="entry name" value="Ribosomal_L23_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012678">
        <property type="entry name" value="Ribosomal_L23/L15e_core_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001014">
        <property type="entry name" value="Ribosomal_L23/L25_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013025">
        <property type="entry name" value="Ribosomal_L25/23"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11620">
        <property type="entry name" value="PTHR11620"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00276">
        <property type="entry name" value="Ribosomal_L23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54189">
        <property type="entry name" value="SSF54189"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00050">
        <property type="entry name" value="RIBOSOMAL_L23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 7 8" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5 7 8" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="4 7 9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 7 9" id="KW-0699">rRNA-binding</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00021203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01369"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PJN10064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="138" mass="15061" checksum="BCBA47CEBEDC601A" modified="2018-04-25" version="1">MATRHPSIAPKAAKAAKAARIAKAKRHEAEGKNTVETPLSKSFTDPRDVLLKPVVSEKSYALLDEGKYTFIVDPRANKTQIKQAVQAVFSVKVTGVNTINRQGKRKRTKTGFGKRADSKRAIVTLAEGDRIDIFGQAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-05-25" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JTD3</accession>
    <name>A0A2M9JTD3_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Deoxyribose-phosphate aldolase</fullName>
            <ecNumber evidence="2">4.1.2.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">2-deoxy-D-ribose 5-phosphate aldolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">deoC</name>
        <name evidence="4" type="ORF">CG723_19200</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CB01635</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>2-deoxy-D-ribose 5-phosphate = acetaldehyde + D-glyceraldehyde 3-phosphate</text>
            <dbReference type="Rhea" id="RHEA:12821"/>
            <dbReference type="ChEBI" id="CHEBI:15343"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="ChEBI" id="CHEBI:62877"/>
            <dbReference type="EC" id="4.1.2.4"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.2.4" evidence="2"/>
    <dbReference type="EMBL" id="NNBL01000006">
        <property type="protein sequence ID" value="PJN10129.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN10129">
        <property type="protein sequence ID" value="PJN10129"/>
        <property type="gene ID" value="CG723_19200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004139">
        <property type="term" value="F:deoxyribose-phosphate aldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009264">
        <property type="term" value="P:deoxyribonucleotide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00959">
        <property type="entry name" value="DeoC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011343">
        <property type="entry name" value="DeoC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002915">
        <property type="entry name" value="DeoC/FbaB/LacD_aldolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10889">
        <property type="entry name" value="PTHR10889"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01791">
        <property type="entry name" value="DeoC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01133">
        <property type="entry name" value="DeoC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00126">
        <property type="entry name" value="deoC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00032755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PJN10129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="316" mass="33329" checksum="73CB0655603CF65B" modified="2018-04-25" version="1">MPTAPAPAFADAVASDRSLRRFLHGLPGVDTVGLEARAASLGTRSIKTTAKAYAIDLAISMIDLTTLEGADTAGKVRALGAKAVHPDPTDRTTPRTAAVCVYPDMVATAKEAVAGSDVKVASVATAFPAGRAALEVKLGDVREAVAAGADEIDMVIDRGAFLAGHYLKVYEEIVAVKEASGAARLKVIFETGELSTYDNIRRASWLGMMAGADFIKTSTGKVGVNATPANTLLMLEAVRDFRAQTGVQVGVKPAGGIRTTKDALKFLVLVNETAGSDWLDNHWFRFGASSLLNDLLMQRQKLSTGRYSGPDYVTVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JTF1</accession>
    <name>A0A2M9JTF1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">TetR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_20525</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000006">
        <property type="protein sequence ID" value="PJN10160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN10160">
        <property type="protein sequence ID" value="PJN10160"/>
        <property type="gene ID" value="CG723_20525"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="4"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="27"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN10160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="186" mass="20418" checksum="5DEF611CA37B274F" modified="2018-04-25" version="1">MSADERRESVIRAAMSEFARGGYYGTSTDAIAKRVGVSQPYLFRLFPGKKAIFLAAATRCVQDATRLFAEASEGLEGEEALHAMANAYTDVIAKDPERLMMQMQVYVAVAAAEAAGDREFGEAVRAEWMKLWEAAHLPLGADVDTTTTFMAYGMLINVLVSMGFPPEHRIWEGLYPSARAMGSLEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-06-02" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JTH4</accession>
    <name>A0A2M9JTH4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_17450</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000005">
        <property type="protein sequence ID" value="PJN10186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN10186">
        <property type="protein sequence ID" value="PJN10186"/>
        <property type="gene ID" value="CG723_17450"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="161"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="164"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN10186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="189" mass="20371" checksum="52D91F297B19F738" modified="2018-04-25" version="1">MGAGHRHADKGAMLARFAARILVVCPRCSGRAVVVPRPGGPELRYSVDLLFLSRRLACARCGVTAEWEPERRGGARIGATLGGPAEPFFGRPLWLQTRCAGRLLWAYDIAHVDALAAYIGARLRERGSPSSSLAMIPRLPGWMTSAANRSEVVAGLAALRAQAERSAPDDRPETADGSAARPQRRRATY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JTI9</accession>
    <name>A0A2M9JTI9_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CG723_19955</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CB01635</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="NNBL01000006">
        <property type="protein sequence ID" value="PJN10148.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN10148">
        <property type="protein sequence ID" value="PJN10148"/>
        <property type="gene ID" value="CG723_19955"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="8">
        <location>
            <begin position="16"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="180"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="279"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="340"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="426"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="281"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="348"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="45"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PJN10148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="530" mass="55714" checksum="E8AB4505B841160D" modified="2018-04-25" version="1">MGTEGEGNVRVIAGRYRLEARIGRGGMGVVWRASDQLLGRRVAVKELVLDETLSADEARRQKDRTLREARAVAQLSHPNVIVVHDVVEHGERPYIVMELIEGGSLADRLSRTGPVDAREAARIGIALIGALRVAHAAGVLHRDLKPANVLVEAGSERVVLTDFGIAQVSGATTLTETGSFVGSPEYTAPERMSGERTGPESDLWSLGAMLCAALTGESPFRRDSLGGIMHAVVVGEIRPPAEAEPLLPVVRGLLERDPERRLGLDEADRLLRAYVATGTTPRSMGGYTPTARNSLTAPAPAPPQKRSARVVLAAAALVAAMAGAGVSAAALLVNGGDGGGTHRPTASAPGPTGDTASPSDSASEPRPTVTVTEQQTGTRPASPAGYRTAVDPEGFSLAVPDDFSRKPDGSRIFYMSPGDTFRIGIKEAAPDPGGPGAVQRRSDAKGPANNPGYRDGSVTDTTHGGRPAALWRFTWNGFSTAEGARHTYDLCWEQGGRMYDVWVSAPVGRIAEAKRYFDTAVATFVPSGGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JTP1</accession>
    <name>A0A2M9JTP1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cysteine hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_17490</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000005">
        <property type="protein sequence ID" value="PJN10192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN10192">
        <property type="protein sequence ID" value="PJN10192"/>
        <property type="gene ID" value="CG723_17490"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.850">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000868">
        <property type="entry name" value="Isochorismatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036380">
        <property type="entry name" value="Isochorismatase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00857">
        <property type="entry name" value="Isochorismatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52499">
        <property type="entry name" value="SSF52499"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Isochorismatase" evidence="1">
        <location>
            <begin position="22"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN10192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="194" mass="20784" checksum="4F32D935254FA446" modified="2018-04-25" version="1">MSRTTLRELNGFDETPAKLAESTLILIDFQNTYTQGVMELDGWEASLDAAAQLLARARQEGTKIVHVINDGGEGTPYDIRAEIGRIHPRVAPVDGEAVVVKQVPNAFVDTDLGTHVPDGQDVIIAGWMTHMCVAFTAQGAFLRGNRPTVVADATATRSLPVAGTDLDACQVHYSALATIADLYGVVVPTQKEIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JTP7</accession>
    <name>A0A2M9JTP7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GNAT family N-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_17790</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000005">
        <property type="protein sequence ID" value="PJN10244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN10244">
        <property type="protein sequence ID" value="PJN10244"/>
        <property type="gene ID" value="CG723_17790"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="26"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN10244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="207" mass="22794" checksum="1FAE5909733ABE84" modified="2018-04-25" version="1">MLTLTDIAEDPLVLTRRLRLRDGSRAVLRPLVHADVKRLADFLAGLSPESRRLSTFDGYDLTAAHELCDAIARYDKLRLVLEDESSERIVGLFELSLALTASDIARYRVAGIPLTERTDCRFGPTLADAYQGSGVGSLVIPLVMEAVRRLGRTRVILWGGVLADNARALRFYEKNGFQLVGPFTGPDGTPSLDMILTLPLHLPPRLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JU55</accession>
    <name>A0A2M9JU55_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_18475</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000005">
        <property type="protein sequence ID" value="PJN10358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN10358">
        <property type="protein sequence ID" value="PJN10358"/>
        <property type="gene ID" value="CG723_18475"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="APH" evidence="1">
        <location>
            <begin position="41"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN10358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="308" mass="32678" checksum="3F0627FF3A511BFC" modified="2018-04-25" version="1">MASTPSPSDGRAGITAALVERLIAAQFPQWSGLPVTPVEVDGWDNRTYRLGDAMTARLPTGAGYVPAVAKENEWLPRLAPSLPVAVPPVLAKGEPGEGYPFPWSVRGWLDGETAARGPIDDMAQFAVSVAEFVLALQRCDGVGGPSAGKHSWYRGASLTHYDDETRRCLAALDGHVDTSRAAAVWEAALAARWQGTPVWFHGDIATGNLLVADGKLTAVIDFGTSGVGDPACDLVIAWCTFSGDSREAFRRTVAQDAGTWARARGWALWKSLLVMSQSLGTDPESAASNHRVIDEVLADHARFGGAGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-05-25" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JUX6</accession>
    <name>A0A2M9JUX6_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Membrane protein insertase YidC</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Foldase YidC</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Membrane integrase YidC</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Membrane protein YidC</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CG723_15645</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">CB01635</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Required for the insertion and/or proper folding and/or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins. Aids folding of multispanning membrane proteins.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Interacts with the Sec translocase complex via SecD. Specifically interacts with transmembrane segments of nascent integral membrane proteins during membrane integration.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13">Membrane</location>
            <topology evidence="1 13">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the OXA1/ALB3/YidC family. Type 1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000004">
        <property type="protein sequence ID" value="PJN10642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN10642">
        <property type="protein sequence ID" value="PJN10642"/>
        <property type="gene ID" value="CG723_15645"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032977">
        <property type="term" value="F:membrane insertase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028055">
        <property type="entry name" value="Membr_insert_YidC/Oxa1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001708">
        <property type="entry name" value="YidC/ALB3/OXA1/COX18"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12428">
        <property type="entry name" value="PTHR12428"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02096">
        <property type="entry name" value="60KD_IMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03592">
        <property type="entry name" value="yidC_oxa1_cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 13 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="22"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="93"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="154"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="209"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00025034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00026028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00031538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00033245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00033342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU003945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="PJN10642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="257" mass="27353" checksum="6956ECE87933CDD4" modified="2018-04-25" version="1">MSTFMSVFASLVEHIADLLDPLFHASATAAAIVLFTAFVRLLVHPLSRASARGQRQRAKLQPRIAELRKKHKKNPEKLQKAIMELHKEEKVSPLSGCLPSLFQLPAFFLLYHLFSNGSIGGEPNALLGHTLGAAPLGGRFKDALADGGLFGAQGVVYLVLFAIVAAVASFNYGRTKRQMAAQPMLPAAADGPQAPGAGAMASMTKIMPLMSFMTLFTVGFVPLAAALYVVTSTTWSAVERAVLYRDMPSAAALATAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JV08</accession>
    <name>A0A2M9JV08_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Xylose isomerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_16155</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000004">
        <property type="protein sequence ID" value="PJN10725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN10725">
        <property type="protein sequence ID" value="PJN10725"/>
        <property type="gene ID" value="CG723_16155"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036237">
        <property type="entry name" value="Xyl_isomerase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013022">
        <property type="entry name" value="Xyl_isomerase-like_TIM-brl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01261">
        <property type="entry name" value="AP_endonuc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51658">
        <property type="entry name" value="SSF51658"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AP_endonuc_2" evidence="1">
        <location>
            <begin position="20"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN10725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="266" mass="28191" checksum="A012D1E1113DFC11" modified="2018-04-25" version="1">MKLAFSTLGVPGLPLADVVRLADEHGYHGVELRAHPEEPVHPGLGPVERADAAAEFKAAGVEILGLAGYARVAAPGEDEPVIAEIRSLLELARDVGAPCVRVFPGGGTEQSRADADATAARRLGTAAEYAADLGVRILLETHDSHRTGADAMRVLGAVGHRQVGALWDVMHTWLGGEQPVASYAALSPHLGYVQVKDIAGADDTTPLALGTGVLPLTEVVDVLCREGWDGWLCWEYEKRWYPDAAPLPGLLTAGREHLARLLNESA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-05-25" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JV32</accession>
    <name>A0A2M9JV32_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_15600</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000004">
        <property type="protein sequence ID" value="PJN10637.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN10637">
        <property type="protein sequence ID" value="PJN10637"/>
        <property type="gene ID" value="CG723_15600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045920">
        <property type="entry name" value="DUF6339"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19866">
        <property type="entry name" value="DUF6339"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="248"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN10637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="288" mass="31887" checksum="6185808763914A19" modified="2018-04-25" version="1">MINKPNHVPDRLGLLDTSAADPFLTEGLLRGEEVHGGIDVAKVVEPLAEDDARWAVEPVRGLVEDAMHEFAADRARADAWLAPRLHATLRLTRREAADKRLWNHMAVAVAPEYVVWRHLPGATVKRRDRRVAAERFLGSPDRQCFSRLWWAAELFRNGSDYAPVETACSNQDLIHSVLRKELIDHRPTAQALVRLLQSGTVTTGREIDGLSVAINAAGATIVYDAFAPDGPRDPESLRRWIAEAESAPPVGRYTLPEGPDEDPAPEESVAGLTKYFAELFETAPVRGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JV67</accession>
    <name>A0A2M9JV67_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_16480</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000004">
        <property type="protein sequence ID" value="PJN10776.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN10776">
        <property type="protein sequence ID" value="PJN10776"/>
        <property type="gene ID" value="CG723_16480"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025058">
        <property type="entry name" value="DUF3995"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13160">
        <property type="entry name" value="DUF3995"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="53"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="85"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="114"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN10776.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="154" mass="16404" checksum="92808E558455BED2" modified="2018-04-25" version="1">MPTDRTARRAATLIASVLSCDAVLHLCWSTGSTWPAHDVKSLSYAVLGADVPFTPPVLLPLATALFTASGVVVARARLNRPHALLCLATWAVAAGLSLRGLAGVYWLFTKDPETAFYWLNLGAYTPLCAGLAAAAVRVARPEPVAHREDAVRVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JVP2</accession>
    <name>A0A2M9JVP2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Sugar phosphate isomerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_16180</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000004">
        <property type="protein sequence ID" value="PJN10940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN10940">
        <property type="protein sequence ID" value="PJN10940"/>
        <property type="gene ID" value="CG723_16180"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036237">
        <property type="entry name" value="Xyl_isomerase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013022">
        <property type="entry name" value="Xyl_isomerase-like_TIM-brl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01261">
        <property type="entry name" value="AP_endonuc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51658">
        <property type="entry name" value="SSF51658"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AP_endonuc_2" evidence="1">
        <location>
            <begin position="13"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN10940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="265" mass="28126" checksum="7A47DCCF08BB05A4" modified="2018-04-25" version="1">MTLKQLGLEELVAACAELDVPGVGLWREPVQTYGVEAAAKLVRGAGLAVTTLCRGGFLTAIDPDARGRALDDNRAAVDEAAVLGTDTLVLVSGGLPEGSRDLHGARERIADALAELGPYAAERGVRLAIEPLHPMYASDRCVVSTLTQALDLAERFPAGQVGVCVDTYHIWWDDRAPAQIARAGAGGRLHAFQLADWTTPLPEGVLNGRGQIGDGAIDMRAWRGLVEAAGYAGPIEVELFNDGLWARDGREVLAETADRFVRHAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JVS9</accession>
    <name>A0A2M9JVS9_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF6286 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_08340</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN11001.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN11001">
        <property type="protein sequence ID" value="PJN11001"/>
        <property type="gene ID" value="CG723_08340"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046253">
        <property type="entry name" value="DUF6286"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19803">
        <property type="entry name" value="DUF6286"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="42"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6286" evidence="2">
        <location>
            <begin position="52"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF19803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN11001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="162" mass="18123" checksum="84019BC109676F50" modified="2018-04-25" version="1">MAFCAIGALLYDVIAVRAGHRAGAWRNRIAEEMTTRPVDDPWLLATGAVAVVLGLWLLILALTPGLRRLLPLRAPEESTEIGAWLDRKGAAMVLRDAAMRVPGVSRARLRVRRRRVTARAEVGFRDTAAVRDDLTQALQEQCRQLALVHTPRLTIRLRHHTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JVW5</accession>
    <name>A0A2M9JVW5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CG723_08645</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN11043.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN11043">
        <property type="protein sequence ID" value="PJN11043"/>
        <property type="gene ID" value="CG723_08645"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PJN11043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="77" mass="8705" checksum="40D970AA197B113D" modified="2018-04-25" version="1">MTLEHPTPPLPISALLRPQMRMEGDLPATQAHQVMLHCALDAACITARMTDYHAVTRIAELDYQTVAAVIRWLRILR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JW11</accession>
    <name>A0A2M9JW11_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CG723_08690</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN11049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN11049">
        <property type="protein sequence ID" value="PJN11049"/>
        <property type="gene ID" value="CG723_08690"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PJN11049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="86" mass="9258" checksum="473379E8C9B5280E" modified="2018-04-25" version="1">MLVVHGVFATAVVRDRTGEPVVLLSGELPEALTPAALDELLNLAAAVLDAEELRLFRSCLSALHCGEKLDERRIEVSGAVLTVYRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JW58</accession>
    <name>A0A2M9JW58_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">SCP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CG723_08980</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN11094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN11094">
        <property type="protein sequence ID" value="PJN11094"/>
        <property type="gene ID" value="CG723_08980"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.33.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014044">
        <property type="entry name" value="CAP_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035940">
        <property type="entry name" value="CAP_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00188">
        <property type="entry name" value="CAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55797">
        <property type="entry name" value="SSF55797"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014624607" description="SCP domain-containing protein" evidence="2">
        <location>
            <begin position="32"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="domain" description="SCP" evidence="3">
        <location>
            <begin position="139"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="36"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="161"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="54"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PJN11094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="256" mass="26752" checksum="6C9D5A3E23800F1A" modified="2018-04-25" version="1">MRKHRKKSYRRPIAIAVIAVGAVGVPSVAMACLDTQGDTGGRPSGHWEKASSHHRWTGSSWGHEPTAGASKSPTATPSAPRSTASPSARQTTASPSAPRSTASPSARQTTASPSAPRTTASPSAPATAAPASGDTARVLTLVNNERSKAGCSPLTMNAKLTKAAQDHSKDMASHRNMSHTGSDGSSPDDRITRAGYSWSSYGENVAYGYSTPEKVMAGWMSSPGHKRNILDCSFKEIGIGLAQPGSYWTQDFGTAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JW68</accession>
    <name>A0A2M9JW68_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Mandelate racemase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_08835</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN11068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN11068">
        <property type="protein sequence ID" value="PJN11068"/>
        <property type="gene ID" value="CG723_08835"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009063">
        <property type="term" value="P:cellular amino acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036849">
        <property type="entry name" value="Enolase-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029017">
        <property type="entry name" value="Enolase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029065">
        <property type="entry name" value="Enolase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018110">
        <property type="entry name" value="Mandel_Rmase/mucon_lact_enz_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013342">
        <property type="entry name" value="Mandelate_racemase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013341">
        <property type="entry name" value="Mandelate_racemase_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13378">
        <property type="entry name" value="MR_MLE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02746">
        <property type="entry name" value="MR_MLE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00922">
        <property type="entry name" value="MR_MLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51604">
        <property type="entry name" value="SSF51604"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54826">
        <property type="entry name" value="SSF54826"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00909">
        <property type="entry name" value="MR_MLE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MR_MLE" evidence="1">
        <location>
            <begin position="148"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN11068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="363" mass="39169" checksum="F0B4C1E372ED3C68" modified="2018-04-25" version="1">MSIVITAATAHLADIEVETVRTDAVQSFVKQETIFVDLTTSEGLTGTGYAYTIGTGGSSVLAMLRDHLLPRLIGQDARRVEGLWQELFSLTRATAVGAITSLALAAVDTALWDLRCKRAGEPLWRLAGGFRQDVPLYDTEGGWLHLSTEDLVKGALDARDKGWSGVKIKVGKEHVSEDVERLRAVREAVGPALHIMTDANQSQTASSALRLAAALEPYAPFWLEEPLPADDVSGHARLARATSIPVAVGESLYSSLQFRQYLESGAASVVQVDVARVGGITPWLKVAHLAETFNVMVCPHFLMELHISLVAAVPNGRFVEYIPQLRAVTRSELAVDGGRALAPDVPGIGIDWDRDALDDRTVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-09-29" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JWN9</accession>
    <name>A0A2M9JWN9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Peptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CG723_10110</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CB01635</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the transglycosylase family. Rpf subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN11279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN11279">
        <property type="protein sequence ID" value="PJN11279"/>
        <property type="gene ID" value="CG723_10110"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00118">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13925">
        <property type="entry name" value="RPF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.70.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.350.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011055">
        <property type="entry name" value="Dup_hybrid_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018392">
        <property type="entry name" value="LysM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036779">
        <property type="entry name" value="LysM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023346">
        <property type="entry name" value="Lysozyme-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016047">
        <property type="entry name" value="Peptidase_M23"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010618">
        <property type="entry name" value="RPF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01476">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01551">
        <property type="entry name" value="Peptidase_M23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06737">
        <property type="entry name" value="Transglycosylas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00257">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51261">
        <property type="entry name" value="SSF51261"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53955">
        <property type="entry name" value="SSF53955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54106">
        <property type="entry name" value="SSF54106"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51782">
        <property type="entry name" value="LYSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015000080" evidence="3">
        <location>
            <begin position="42"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="domain" description="LysM" evidence="4">
        <location>
            <begin position="162"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="212"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="219"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="274"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010830"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PJN11279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="403" mass="42344" checksum="54570E6E18662638" modified="2018-04-25" version="1">MAVRGRHRRYQPNRINRASLTVTAGSAGMAIPLIGAGVAHAADANTWNKVAACESSGNWSINSGNGYFGGLQFTQSTWEAYGGTAYAARADRATRGQQIAVAEKVLDGQGPGAWPVCSARAGLTRGGDTPGPHTETVKHKPQRTVKDVKPEVTPQSTAGTAQMYTVVGGDTLSGIADAREVPGGWRKLYEANRRTIGSDPDFILPGQRLALHPSAKPRDPAAPQKRERPAQKPSQKHDKSDQKRETAAPAKKTGTATATRPRTEKPAASHDVTAPVSASLSTPYRAAGSSWSKGYHTGVDFAVSTGTTVKAIASGHVVSAGWGGSYGYEVVIRHADGKYSQYGHLSALSVKAGQRVVGGQRIARSGSTGNSTGPHLHFEVRTGPGFGSDVDPLAYLRAHGVRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JWP7</accession>
    <name>A0A2M9JWP7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">GGDEF domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CG723_10365</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN11326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN11326">
        <property type="protein sequence ID" value="PJN11326"/>
        <property type="gene ID" value="CG723_10365"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd01948">
        <property type="entry name" value="EAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01949">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001633">
        <property type="entry name" value="EAL_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035919">
        <property type="entry name" value="EAL_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000160">
        <property type="entry name" value="GGDEF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001610">
        <property type="entry name" value="PAC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000700">
        <property type="entry name" value="PAS-assoc_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00563">
        <property type="entry name" value="EAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00990">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13426">
        <property type="entry name" value="PAS_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00052">
        <property type="entry name" value="EAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00267">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00086">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141868">
        <property type="entry name" value="SSF141868"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="SSF55073"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00254">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50883">
        <property type="entry name" value="EAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50887">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50113">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PAS" evidence="1">
        <location>
            <begin position="153"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="domain" description="PAC" evidence="2">
        <location>
            <begin position="227"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="domain" description="GGDEF" evidence="4">
        <location>
            <begin position="309"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="domain" description="EAL" evidence="3">
        <location>
            <begin position="453"/>
            <end position="712"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PJN11326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="714" mass="78203" checksum="53E503ADAC3C33B0" modified="2018-04-25" version="1">MSGEPDGPEGRLRRFATIWSRAIFPVTATSLTRVEFEKELMPLARRLRDALGERTLDAPAAQAVGAALIGVHCTDPEALTRTLDVVDAYLVLYCRTDEDRREEELRARCARLQHSVAAGFAQALRERTLVEQEAISRAALSARSAVAEALHASEARFRAVFHGAAIGIGIADLEGTVLEANDALVRMFGGAENLVRGRNVVEWTHPDDPPHVWRLYEELVRGEREHYRVEKAFYRPDGTALWTNLTVSLLRDADGVPQYQLALMEDTTERRLLNLRLRYEATHDALTGLPNRTLFFERLEKALAAGDGMRFGLCYLDLDGFKTINDSLGHAAGDRLLVEVADRLQACATAPGEMVARLGGDEFVALTTGRDTAAEVDDLAGRIMHALAAPIRIDGRELTVRGSIGIVEGPAAGERSPAEVLRSADITMYRAKSAGGNRYELADPEADARAITRHGLTTALPAALERGEFFIEYQPLVHLGDGSVRGAEALVRWLHPQHGVLGPDQFIPLAEDTGLIVPLGRWVLEESVRQARVWQERYEDAGPLRINVNLSPMQLTHPGLVSDTVDILERFGLEPGALCLEVTESALIGADDDLLKPLRRLAEMGVDIALDDFGTGYSNLANLRRLPVSVLKLDRSFTQGMQRYPADPVDLKIVEGIVALAHSLDLSVTVEGVETGAQAEQLRDLGCDTAQGWYYARPGPPDRLHELALCDASG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JWT1</accession>
    <name>A0A2M9JWT1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">LLM class flavin-dependent oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_10410</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">To bacterial alkanal monooxygenase alpha and beta chains.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN11334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN11334">
        <property type="protein sequence ID" value="PJN11334"/>
        <property type="gene ID" value="CG723_10410"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011251">
        <property type="entry name" value="Luciferase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036661">
        <property type="entry name" value="Luciferase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019949">
        <property type="entry name" value="Luciferase_OxRdatse_group-1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00296">
        <property type="entry name" value="Bac_luciferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51679">
        <property type="entry name" value="SSF51679"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03558">
        <property type="entry name" value="oxido_grp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bac_luciferase" evidence="2">
        <location>
            <begin position="9"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007789"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN11334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="335" mass="35877" checksum="574BEDBBDC160DE8" modified="2018-04-25" version="1">MSSVIASTRFSVLDRSRTREGHDGPSALRDTVRFARELDALGYHRVWVSEHHGVPGVAGSAPTVLAAAVAAATRTIRVGTGGVMLPNHQPLVVAEQFGVLESLFPGRIDMGLGRSVGFTGGVRKALGRDKDDADDFAAQLAELLDFFRGTSTTGVRARPSDGLTVPPFVLAMGEGATIAAEAGLPMVVGDLRNREKMLRAIDRYRASFRPSAWAGEPYVVVSGTIAVAGSPEAAHRLLIPEAWSMAYSRTHGTFPPLPPAERVEALTMTTKERDFYESGLRGHIAGTEDQVADELETLIKESGAQEVLVTTSSYDREGLLESYRGLARVAGLHRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JX21</accession>
    <name>A0A2M9JX21_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_11055</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN11440.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN11440">
        <property type="protein sequence ID" value="PJN11440"/>
        <property type="gene ID" value="CG723_11055"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014509">
        <property type="entry name" value="UCP020606"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09997">
        <property type="entry name" value="DUF2238"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF020606">
        <property type="entry name" value="UCP020606"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="24"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="49"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="75"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="119"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="148"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="193"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN11440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="222" mass="24096" checksum="301BF96C6FA6A40A" modified="2018-04-25" version="1">MSLIAAARRRAANTPAPSPAPSPVLPRVCVAVVVAGVALSAWAPHDRTTWLLEVVWVLIGLPLVVLTWRRFQLSGLLCCLLAAHALVLALGGHYTYAQVPLGEWVQDGLGLSRNPYDRFGHLMQGFVPAILVRELLIRTSSLRGSRWLAPLTVCACLAFSAAFEMFEWAAAVIGGQAADAFLATQGDVWDTQWDMFCALIGATVSLLLLSKWHDSRLNRLAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-09-29" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JXT3</accession>
    <name>A0A2M9JXT3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_12590</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN11696.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN11696">
        <property type="protein sequence ID" value="PJN11696"/>
        <property type="gene ID" value="CG723_12590"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.2880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038468">
        <property type="entry name" value="MmpS_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="SSF50156"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014902921" evidence="2">
        <location>
            <begin position="27"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="23"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN11696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="150" mass="15211" checksum="2D247BA3A560FDB1" modified="2018-04-25" version="1">MRRTVTGIALVAATAALLAGCGSGGGDSKEAGAKQDTSKAPSHAASKPAGGQEATREVTFEVQGQGSTQVLWTAGESKTEQVNLPWTKTTRLTIKGAELKVGSLVSVVPGSVAASDGRLEPASCVIKVDGKQVADNKDGKSIAGCKYLVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JXV8</accession>
    <name>A0A2M9JXV8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Methyltransferase type 11</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_12665</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN11710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN11710">
        <property type="protein sequence ID" value="PJN11710"/>
        <property type="gene ID" value="CG723_12665"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041698">
        <property type="entry name" value="Methyltransf_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13649">
        <property type="entry name" value="Methyltransf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransf_25" evidence="2">
        <location>
            <begin position="107"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="292"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN11710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="323" mass="33955" checksum="1E8313CF00AF2132" modified="2018-04-25" version="1">MQLIEISDLVVDHDPGTRARLPVRGADVVARLVAAGDRSGARIAAGLACDDDGNLDPLAVDRRLVAVHTELQRLSEELRLGDRIAELLRPLLAVIRAAGRTDGPLRVVDVGCGLGYLVRWLAASGALGPDVDLVGVDFNAALVTEAGRLARAEALPCRFVRGDAFALDEPATVYVSTGVLHHFRGDDLDAFFAAQATPGTAAFCHFDIAATGLAPIGAWVFHRARMRDPLGRHDGVMSARRAHDDETLLAAAAHADGLTPLVYEPRGRSNPFCTTLRPVIGVRPDLLPPLRAELGPGPSGRLVGRADTVGGTRHGASAGEGVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JXZ8</accession>
    <name>A0A2M9JXZ8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Enolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CG723_12940</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CB01635</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="3">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN11756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN11756">
        <property type="protein sequence ID" value="PJN11756"/>
        <property type="gene ID" value="CG723_12940"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009063">
        <property type="term" value="P:cellular amino acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036849">
        <property type="entry name" value="Enolase-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029017">
        <property type="entry name" value="Enolase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029065">
        <property type="entry name" value="Enolase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033978">
        <property type="entry name" value="L-talarate_dehydratase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018110">
        <property type="entry name" value="Mandel_Rmase/mucon_lact_enz_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013342">
        <property type="entry name" value="Mandelate_racemase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013341">
        <property type="entry name" value="Mandelate_racemase_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13378">
        <property type="entry name" value="MR_MLE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02746">
        <property type="entry name" value="MR_MLE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00134">
        <property type="entry name" value="L-talarate/galactarate_dehydra"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00922">
        <property type="entry name" value="MR_MLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51604">
        <property type="entry name" value="SSF51604"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54826">
        <property type="entry name" value="SSF54826"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00909">
        <property type="entry name" value="MR_MLE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MR_MLE" evidence="5">
        <location>
            <begin position="171"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="2">
        <location>
            <begin position="41"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="2">
        <location>
            <begin position="77"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="1">
        <location>
            <position position="192"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="1">
        <location>
            <position position="323"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="190"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="221"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="223"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="247"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="273"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="343"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Increases basicity of active site His" evidence="4">
        <location>
            <position position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR633978-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR633978-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR633978-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR633978-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PJN11756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="393" mass="42861" checksum="B3D5D02B3C5F0747" modified="2018-04-25" version="1">MVTKTHTTTNAAHVAGEATLDRISWIRLSSVTLPLATPISDAKVLTGRQKPMTEVAFLFVELETEQGHEGIGFSYSKRAGGPGQFAHAREIADDLLGEDPSDIGKIWTKLAWSGASVGRSGLATQAIAAYDVALWDLKAKRAGLPLAKLLGAHRDSVRCYNTSGGFLHTPTEQVLDNASASLASGIGGIKIKVGNPDRKQDLRRLTAVREHIGDDAPLMVDANQQWDRPTAQRMGRAMEEFDLVWIEEPLDAYDAQGHAALAASLDTPIATGEMLASVAEHWELIRNNAADIIQPDAPRIGGITQFLKLAALAEHHNLQLAPHFAMEIHLHLAAAYPIEPWVEHFDWLEPLFNERLTISDGRMHVPSRPGLGITLTDQARAWTQATHEAGKRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JY25</accession>
    <name>A0A2M9JY25_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CG723_13090</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN11780.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN11780">
        <property type="protein sequence ID" value="PJN11780"/>
        <property type="gene ID" value="CG723_13090"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="6"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="38"/>
            <end position="45"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PJN11780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="300" mass="32465" checksum="D6B4089C4F95CEAC" modified="2018-04-25" version="1">MTEMALATDALGKRYGRTWALQECSLHLPAGRIAGLAGPNGAGKSTLLHLAVGLLRPDAGQVRVFGQDPHNNTAVLREVGFVAQDTPLYREFTAADHITLGGRLNSRWDAAFARERIDRLDIPLKKPVGKLSGGQRAQVALALAMAKRPRLLLLDEPVAALDPLARREFMQALMGVVAESGTTVLLSSHLVADLERVCDYLIVLQKAHVRLAGSIDELLDEHRTLVGPRTEPGAVPMEGPAQVINASHTDRQSTLLVRTQGRPVDDPAWTRHEVTLEDLVLAYLHTADSRAACTVSEVTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JYA4</accession>
    <name>A0A2M9JYA4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Crp/Fnr family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_13440</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN11838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN11838">
        <property type="protein sequence ID" value="PJN11838"/>
        <property type="gene ID" value="CG723_13440"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00038">
        <property type="entry name" value="CAP_ED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018490">
        <property type="entry name" value="cNMP-bd-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000595">
        <property type="entry name" value="cNMP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045641">
        <property type="entry name" value="MmpI-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00027">
        <property type="entry name" value="cNMP_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19307">
        <property type="entry name" value="PCLP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51206">
        <property type="entry name" value="SSF51206"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50042">
        <property type="entry name" value="CNMP_BINDING_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="2">
        <location>
            <begin position="107"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="232"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN11838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="481" mass="53544" checksum="B0C9FAEAA289CC94" modified="2018-04-25" version="1">MSVPDSATGPASDEETAPEVPTDQQLTSLGTHAARRLATTTKSAPQMQAITSRWLLKSLPWVDVKGGTYRVNRRLQLSIGRGRVQFDQNGGNDIKVIPETLTELPVLRGYDDIDVLKEIATRFRTREVRAGQILFEAGQPVTEAYLVAHGRFTRFTEGKYGDEEVIGVVTDGDQMGDEAIGQPDPLWLSSVRAETAGTVLVLPWDVVEELTERTPSLDAHLREYVERQRLPRNRKGEADVPVQSGHTGEPTLSGGFVDYELTPREYELSLTQTVLRVHTRIADLYNDPMDQTEEQLRLTIEEIRERQEWELLNNHEFGLLHNVDYGQRISTFSGPPTPDDLDELLSMRRKTKLFLAHPKAIAAFFRQCNRRGLVPGTANVDGHEVPAWRGVPLFPCGKIPVTPQHTTSILALRTGESDQGVVGLYQTGIPEEYQPGLNVRFMGINTTAIINYLVTAYYSLAILVPDAAGILENVQIGRTAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JYB5</accession>
    <name>A0A2M9JYB5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Nitrate reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CG723_13540</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CB01635</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the purine-cytosine permease (2.A.39) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN11854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN11854">
        <property type="protein sequence ID" value="PJN11854"/>
        <property type="gene ID" value="CG723_13540"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001248">
        <property type="entry name" value="Pur-cyt_permease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045225">
        <property type="entry name" value="Uracil/uridine/allantoin_perm"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30618">
        <property type="entry name" value="PTHR30618"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02133">
        <property type="entry name" value="Transp_cyt_pur"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="57"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="123"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="165"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="192"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="233"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="272"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="314"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="357"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="380"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="434"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="460"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PJN11854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="496" mass="53538" checksum="46F4B0B0007191FF" modified="2018-04-25" version="1">MAAVHESPPTAAVDGKPRTSPGLYSPDLAPTKKEGRRWGAYSVFTLWGNDVHSLGNYAFAIGLFALGMSVWNILAAFAIASALLFLLLTLSGYMGSKTGVPFPVMSRISFGVKGAQIPAIVRGVVAIAWFGIQTYLAASVLGALVKVLFPGLRPLDENSILGLSTLGWATFLTLWVIQVVIVSYGMELIRKYMAFAAPTILITMSALAIWMFIRADGSISMSTGHAPHGLDMWRQIFESAALWVVIYGTFVLNFCDFTRSAKSRRAIVRGNLVGIPVNMLFFAGIVVVLSGAQFKLNGEVITGPEDIVRSIPNTFLMAAASLAFITLTIAVNLMANFVAPIYALVNLFPRTLNFRRSGVVSAVIGLVILPWNLYDNPTVVNYFLGGLGALLGPIFGVVMADYWLVRRTRVNVPDLYTDDRQGDYFYQRGFHLKAIAAFVPAAAVAVVIALVPAFKSVSGFSWFIGAVLSAVVYLVLADRQKATRDVDGESIAVDAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JYC4</accession>
    <name>A0A2M9JYC4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Phosphoesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CG723_13735</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN11886.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN11886">
        <property type="protein sequence ID" value="PJN11886"/>
        <property type="gene ID" value="CG723_13735"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042578">
        <property type="term" value="F:phosphoric ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044003">
        <property type="term" value="P:modulation by symbiont of host process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007312">
        <property type="entry name" value="Phosphoesterase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04185">
        <property type="entry name" value="Phosphoesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="SSF53649"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0843">Virulence</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014902926" evidence="3">
        <location>
            <begin position="47"/>
            <end position="920"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="245"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="457"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="796"/>
            <end position="820"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="255"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="805"/>
            <end position="820"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PJN11886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="920" mass="98886" checksum="E653CDEDE64A1BAB" modified="2018-04-25" version="1">MQVTRRRRRTAKDRSGLLGRRIGRRIPLATAGISALALAAAGTAFAQTHQFGTDQVGQSTRQGQVISSDQYIAPYGDRLVVNNGKIMSSSVSPDGTHLAASITDGGMALSVVDLKSWKVQQLVGNSASADLRISGNDVGQEGPTYSPDGSQLWLGQIDGYTRFTVNADGSVANPTSVKIPADGPRHALVGEPVFSSDGSTVYSAVNGQNRVVAIDAATGAIERSWSVGNAPRDMAEVGTKLYVSNEGGRPAKPRDTTINSYNTQVPADPVTASTTTGTVSVIDLANPDAAVSSINVGLHPTALYAKKNALFVTNTATNDVSVIDTTKNKVVQTVATQPWPESSVGYEPDAVTLTDDGHLLVTLGRANAVAVYRYTTPQEPVSYVGLLPTDYFPAEIATVGKQVVVSNTRGIDARRPTTSAGHATHDTTSSVQRFTLPNDRVIKSQTAKVFRQNGWTSGSVTLTHGKGKKKPKPVPVPERLGDPSTIKHVFLIVKENRTYDQVLGDVPEGNGDPSLAQFGENVTPNQHALAKQFGLYDNTYDIGTNSAEGHNWLMQADDPEYTESSAGEYARSYDTEDDALGHQRTGFIWTGAQAAGKSVRDFGEFQQFLTKPADASWQNLYCDSKNMGATGQDTAYPLVSSSPIPSLNSVSVHGFPKFDTSVPDIYRSEIWKRDFEKNGPANLNMFWLSSDHTGGPANAAAQVADNDLAVGRMVDEISHSKYWKDSAIFVVEDDSQAGLDHVDGHRAPIQIISPWARHGVVDSHYYSQITMIRTIEQILGVHPMNQKDSAASPMRGAFSQKADPTPFKTLPNRTSLTGGLKTPPSCGLDTPAPQNPNAAAAPSAKVPADKQKLAAQWDAWKSQQRLTGRDAKPDFANPAQMNHFTWYQTHEWSKPYPGENKIFAPKDVPGAYIPSPESDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-09-29" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JYG9</accession>
    <name>A0A2M9JYG9_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F5/8 type C domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CG723_13915</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN11915.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN11915">
        <property type="protein sequence ID" value="PJN11915"/>
        <property type="gene ID" value="CG723_13915"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000421">
        <property type="entry name" value="FA58C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00754">
        <property type="entry name" value="F5_F8_type_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="SSF49785"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50022">
        <property type="entry name" value="FA58C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014637729" description="F5/8 type C domain-containing protein" evidence="2">
        <location>
            <begin position="38"/>
            <end position="1049"/>
        </location>
    </feature>
    <feature type="domain" description="F5/8 type C" evidence="3">
        <location>
            <begin position="624"/>
            <end position="718"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="181"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="941"/>
            <end position="967"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PJN11915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="1049" mass="112796" checksum="0C11DBCF8D81ABB9" modified="2018-04-25" version="1">MSHHPMQVDRRRFLQLLGLSSALAALPTVAVANSAQALDSSPGSASPPDETAATYHRVLLQHTHWSETQWDEARGHYTDKDFGFAVVLGHAVLLRHGTYDNELAGVDRDTLKARTLATIRHFAASNRLTGGTQWGRKLFFDTTFQSYFILAARLLWDDLDSATRTNVDTIIREQAAYTTTLGTGDDPDSGDWTPNGLKGGHVGDTKLEEMGLYAQTLAPALAWAPDDARRPDWESGYGTWSRNEAGLPPADLANPALVDGVAVSRNTARNLYDTFIVENHGSFGPHYQEELWRTSGRNAAHFLAAGQPLPQVLTAQPNAQPLWRTLLGVMSDAGEPLMPMVNDREHLYGRDVIPLAFLAQVTGDRAAARAEQALAERLEAYQKYPPEYRLAKFSGEPKYEPEARAELAISYLLHMWAAAKGERVRPLSADELFAQASGVTDFGSGPGLVSHQTRAAWAGAVSKPGFVKFAWQPAHDDWLFKLSGGTPMFLPATTGKVARRTVRTYTSRRDGFDGSATVLRLDSGYAGFTTLPTGAVVYATSGTTAGEGHLEVHNLTMPGMAGLDGARTYRFEEGEVEVRAQDADTSPTAAAARVDEVSFSRATVRHIRMLGVRPDPTYGYSLYAFEVRDGADGTDLARGATATSSSNDPGKGPELAVDGDLATRWAVAKAERPRADSWLTVDLGPEREVDRVTLRWEAAAGRAYRVQGSADGERWEDLAAWPVPDVSSRGGWLDIDGRAGLVVRGSDADHPIAVYGDTILAADGPAAPVVVEGYAGASANTLRALARIASPRAGSKAIQVAFTQEHLSLFNLSGDAVTTTVDVPQSGARRLVFQGDQTLTDGGTTYQAEVEASEALLLAPRFTLAPVAGAGRLPSGLRVRVMDGATVQLSGASCRVRVEGQHRSEVAVVRRGRETTLRLHDVTAFPLDDLALDRTVFPTSPLPAGMSDPSAAVDGNPATSWRPGPDGRMVVDLGERLPLRSVEVTWTDAGAPALSVEVSDDGVAYRGAGRADGRGRVRALGLDTSARYVAVKVEGRLSRDARLTRLTLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JZG4</accession>
    <name>A0A2M9JZG4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Sugar ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CG723_04120</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CB01635</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000002">
        <property type="protein sequence ID" value="PJN12256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN12256">
        <property type="protein sequence ID" value="PJN12256"/>
        <property type="gene ID" value="CG723_04120"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="79"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="112"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="139"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="197"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="246"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="75"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PJN12256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="279" mass="30838" checksum="C48FA7775AC25FCC" modified="2018-04-25" version="1">MRDESRVRAGRALRLALLIALALLFLIPFYLLVRNGLAAESDITSPEWTFFPSSLRWGNVRELFADTSVPYARSLLNSALIAVATTLGTLLLASLAGYGLARIPYRHANKVFYAILGTLTVPAAVTFVPSFVLVSSLGWISTLRGLIVPTLFSAFACFVFRQYFLGFPGELEDAARVDGLGYWRTYWRVVVPNSRPVFAAVGTIVFIGAWNSFLWPLVIGQDRNAWTVQVALSSFTTAQVVRLHELFIAAAVSIVPLLVVFLFFQRWIVAGVERSGIDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JZR1</accession>
    <name>A0A2M9JZR1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_04705</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000002">
        <property type="protein sequence ID" value="PJN12356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN12356">
        <property type="protein sequence ID" value="PJN12356"/>
        <property type="gene ID" value="CG723_04705"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015006596" evidence="2">
        <location>
            <begin position="25"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="33"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="33"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN12356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="77" mass="7539" checksum="6B7DBBC832D71ACE" modified="2018-04-25" version="1">MRIRRILAAVFATAALAGLGLTGAATATATAGSVTPTSVTPTSVTPGECTDGGGTIDRSTPMLPTCRGGMNDGQTVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K0D2</accession>
    <name>A0A2M9K0D2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Hydroxyacid dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CG723_06045</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CB01635</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000002">
        <property type="protein sequence ID" value="PJN12591.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN12591">
        <property type="protein sequence ID" value="PJN12591"/>
        <property type="gene ID" value="CG723_06045"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006139">
        <property type="entry name" value="D-isomer_2_OHA_DH_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029753">
        <property type="entry name" value="D-isomer_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029752">
        <property type="entry name" value="D-isomer_DH_CS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006140">
        <property type="entry name" value="D-isomer_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00389">
        <property type="entry name" value="2-Hacid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02826">
        <property type="entry name" value="2-Hacid_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00065">
        <property type="entry name" value="D_2_HYDROXYACID_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00671">
        <property type="entry name" value="D_2_HYDROXYACID_DH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="2-Hacid_dh" evidence="4">
        <location>
            <begin position="8"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="domain" description="2-Hacid_dh_C" evidence="5">
        <location>
            <begin position="110"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005854"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PJN12591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="334" mass="36518" checksum="EC651286CB080880" modified="2018-04-25" version="1">MEILAFGVQSDEKPLMEKAFEGHHEVRCLGVFLNEDTAPIAAGYEIISTSVNATLNNRVLQTLAAGGTQMIAQRSTGFNNIDLEVAERLGLTVARVSYYSPYSVAEFAWTLAMAVNRRVVRASNRTRDFDFRLDGLMGRDLRGRTVGVLGTGKIGEAFTRIAHGFGMNLLGWDIAENPACVELGMKYVDKERLFTDADLISLHVPLLPATEHLVGSAALRTMKDDAILVNSSRGGLIDTKALVSELREGRFTGVGLDVYEAEAGLFFLDKSLDVVEDDTLARLVTFPNVLVTSHQAYYTVDAVNQIIETTVANVLDYRAGRRSENVLVPSAPKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K0D6</accession>
    <name>A0A2M9K0D6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CG723_06055</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000002">
        <property type="protein sequence ID" value="PJN12593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN12593">
        <property type="protein sequence ID" value="PJN12593"/>
        <property type="gene ID" value="CG723_06055"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012638">
        <property type="entry name" value="Trp_leader1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08055">
        <property type="entry name" value="Trp_leader1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PJN12593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="28" mass="3234" checksum="6B4D824908EC10DE" modified="2018-04-25" version="1">MSCPSGRVPPMFAHTTRNWWWTAHPAAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K0K3</accession>
    <name>A0A2M9K0K3_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 12">Anthranilate synthase component 1</fullName>
            <ecNumber evidence="5 12">4.1.3.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">trpE</name>
        <name evidence="15" type="ORF">CG723_06455</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">CB01635</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11 12">Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine-binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 12">
            <text>chorismate + L-glutamine = anthranilate + H(+) + L-glutamate + pyruvate</text>
            <dbReference type="Rhea" id="RHEA:21732"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16567"/>
            <dbReference type="ChEBI" id="CHEBI:29748"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="EC" id="4.1.3.27"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2 12">Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 1/5.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4 12">Heterotetramer consisting of two non-identical subunits: a beta subunit (TrpG) and a large alpha subunit (TrpE).</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the anthranilate synthase component I family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.3.27" evidence="5 12"/>
    <dbReference type="EMBL" id="NNBL01000002">
        <property type="protein sequence ID" value="PJN12663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN12663">
        <property type="protein sequence ID" value="PJN12663"/>
        <property type="gene ID" value="CG723_06455"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00035">
        <property type="reaction ID" value="UER00040"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004049">
        <property type="term" value="F:anthranilate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000162">
        <property type="term" value="P:tryptophan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005801">
        <property type="entry name" value="ADC_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019999">
        <property type="entry name" value="Anth_synth_I-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006805">
        <property type="entry name" value="Anth_synth_I_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005256">
        <property type="entry name" value="Anth_synth_I_PabB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015890">
        <property type="entry name" value="Chorismate_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11236">
        <property type="entry name" value="PTHR11236"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04715">
        <property type="entry name" value="Anth_synt_I_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00425">
        <property type="entry name" value="Chorismate_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00095">
        <property type="entry name" value="ANTSNTHASEI"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56322">
        <property type="entry name" value="SSF56322"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00564">
        <property type="entry name" value="trpE_most"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 12" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="9 12" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="10 12" id="KW-0456">Lyase</keyword>
    <keyword evidence="12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 12" id="KW-0822">Tryptophan biosynthesis</keyword>
    <feature type="domain" description="Anth_synt_I_N" evidence="14">
        <location>
            <begin position="26"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="domain" description="Chorismate_bind" evidence="13">
        <location>
            <begin position="224"/>
            <end position="476"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00020653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00025634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU364045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF04715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="PJN12663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="493" mass="53152" checksum="A1599E460C6DD3B8" modified="2018-04-25" version="1">MDLETFRKLATDRRVIPVSRKLLADGDTPVGLYRKLAGERPGTFLLESAENGRSWSRYSFVGVRSAGTLTTRDGQAHWLGTPPVGVPTHGDPLAALRATVETLHTPRYEGLPPFTGGMVGYLGYDIVRRLEKIGPGERDDLKLPELTMLLTSDLAVLDHWDGSVLLIANAINHNDLDTGVDEAYADAVARLDAMEADLSRPVVQAPASLPASELPQFTALWGGTDYQEAVEDIKERIRAGEAFQVVPSQRFETPCTASALDVYRVLRATNPSPYMYLFRFDGFDVVGSSPEALVKVEDGRAMVHPIAGTRPRGATPQEDQALADELMADPKERAEHLMLVDLGRNDLGRVCEPGSVEVVDFMSVERYSHVMHIVSTVTGRVAPGTTAFDVLTACFPAGTLSGAPKPRAMQIIDELEPSRRGLYGGCVGYLDFAGGSDTAIAIRTALLRDGTAYVQAGAGVVADSDPVAEDTECRNKAAAVLRAVHTANRMHGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-09-29" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K0N3</accession>
    <name>A0A2M9K0N3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">1-acyl-sn-glycerol-3-phosphate acyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_06025</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000002">
        <property type="protein sequence ID" value="PJN12587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN12587">
        <property type="protein sequence ID" value="PJN12587"/>
        <property type="gene ID" value="CG723_06025"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002123">
        <property type="entry name" value="Plipid/glycerol_acylTrfase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01553">
        <property type="entry name" value="Acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00563">
        <property type="entry name" value="PlsC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PlsC" evidence="2">
        <location>
            <begin position="29"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="223"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="223"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN12587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="258" mass="27701" checksum="5F2810ABECF1F4B8" modified="2018-04-25" version="1">MKVAIGGPLKLGFRPWVEGLENIPAEGPAILASNHLSFSDSFFLPAVLDRKVTFIAKAEYFTTPGVKGKLTAAFFKGVGQLPVDRSGSRGAGEAAIKSGIEVLERGELFGIYPEGTRSPDARLYRGKPGGLARVALATGAPVIPVAMIDTEKIQPPGKVLPKLMRPGIRIGKPLDFGRYQGMEHDRFVLRALTDEVMYEIMKLSGQEYVDMYATAAKRQIADAAKAEAKAEKEARAEKEAAEKEAGENKGGGTERPAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K145</accession>
    <name>A0A2M9K145_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">GntR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CG723_07465</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000002">
        <property type="protein sequence ID" value="PJN12841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN12841">
        <property type="protein sequence ID" value="PJN12841"/>
        <property type="gene ID" value="CG723_07465"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.530">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011711">
        <property type="entry name" value="GntR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008920">
        <property type="entry name" value="TF_FadR/GntR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07729">
        <property type="entry name" value="FCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
        <property type="entry name" value="GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00895">
        <property type="entry name" value="FCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00345">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48008">
        <property type="entry name" value="SSF48008"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50949">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH gntR-type" evidence="4">
        <location>
            <begin position="10"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PJN12841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="216" mass="22851" checksum="E3D3CDFED98ED26D" modified="2018-04-25" version="1">MAAIRRVQRTLLRDQACTAIRDAIVGGDIAPGAVVRDADLAELLGLSRAPVRAAFSRLVDEGLLETKPQSHTRVTPVVAADVRDAAAVVRAMHELAVRTAVPRLARADTDAMREANARFAAAVAAGDVDAALRADDELHGVPVRVSGNRAAAATIARYTPLIRRLERRRFGQGAACGSAEPHARLIDACAAGDAAGAVRITTEIWRVLEELADEEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K199</accession>
    <name>A0A2M9K199_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CG723_07820</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000002">
        <property type="protein sequence ID" value="PJN12905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN12905">
        <property type="protein sequence ID" value="PJN12905"/>
        <property type="gene ID" value="CG723_07820"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PJN12905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="251" mass="26104" checksum="09898617F26EF883" modified="2018-04-25" version="1">MDLGLKDRVYVVTGATRGLGNAAARELVADDAKVIITGRDEKRVAEAAEALGENAVGVAADNADPDVARRLIEAARENFGGFDGVLISVGGPAPGFLADNTDEQWESAFESVFLGAVRLARSAAAELGEGGVIGFVLSGSVHEPIPGLTISNGLRPGLAGFAKSLADELGPRGIRVVGLLPARIDTDRVRELDGLSADPEATRAANEARIPLRRYGRPEEFGRAAAFFLSPAASYLTGVMLPVDGGSRHGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K1Y1</accession>
    <name>A0A2M9K1Y1_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Alginate_lyase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_00635</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000001">
        <property type="protein sequence ID" value="PJN13142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN13142">
        <property type="protein sequence ID" value="PJN13142"/>
        <property type="gene ID" value="CG723_00635"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042597">
        <property type="term" value="C:periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008397">
        <property type="entry name" value="Alginate_lyase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008929">
        <property type="entry name" value="Chondroitin_lyas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05426">
        <property type="entry name" value="Alginate_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48230">
        <property type="entry name" value="SSF48230"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014644132" description="Alginate_lyase domain-containing protein" evidence="1">
        <location>
            <begin position="45"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="domain" description="Alginate_lyase" evidence="2">
        <location>
            <begin position="117"/>
            <end position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05426"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN13142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="408" mass="44588" checksum="9742B41925DD6A52" modified="2018-04-25" version="1">MPNTPAPARHRRRRRTALLATLATTTAALVATLLAWPGADRADAAPATFAHPGVTVSKGQLDFARDKVNAGAQPWKGAYDQMLASKYASLTRTAKPRATVECGSYSNPNYGCTDEREDAIAAYTDALAWYITRDDRYAKKAIELMDAWSATIKEHTNSNAPLQTGWAGSSWPKAAEIIKYTYTGGWANEGRFRTMLRDVYLPKVINGSNSNGNWELSMMEAAVGISVFLEDKTSYDKAMAKFRTRTAAYVYLASDGDLPKTVPSQNLDTKAKIVSYWQGQSTFVTGLTQETCRDFVHTGYGISAISHIAETSRIQGQDLYGTDVGQRLQQALGFQAKYELGEAPPSWLCGGSVTRGLGPVTEVGYNAMHTRLGNAMTNTQKLTEQNRPAGSNNLFVAWETLTHAENPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K203</accession>
    <name>A0A2M9K203_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_00750</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000001">
        <property type="protein sequence ID" value="PJN13159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN13159">
        <property type="protein sequence ID" value="PJN13159"/>
        <property type="gene ID" value="CG723_00750"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="64"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="88"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="113"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN13159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="140" mass="15206" checksum="CD8BE9705BA46292" modified="2018-04-25" version="1">MTATHSQPADTTKQAWAGGLTIFAGVMLMLVGVLGICRGIMGIAKDDIFVTTRNYIFQFDLTGWGWVHLVLGVLAVIVSFGLLQTATWARVGGVAIAGLVIIANFLSLPYYPVWSVVLIAISGFIIWALCVVRKDESDWF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K206</accession>
    <name>A0A2M9K206_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">RNA methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CG723_00695</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CB01635</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000001">
        <property type="protein sequence ID" value="PJN13153.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN13153">
        <property type="protein sequence ID" value="PJN13153"/>
        <property type="gene ID" value="CG723_00695"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008173">
        <property type="term" value="F:RNA methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030391">
        <property type="entry name" value="MeTrfase_TrmA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002792">
        <property type="entry name" value="TRAM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010280">
        <property type="entry name" value="U5_MeTrfase_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11061">
        <property type="entry name" value="PTHR11061"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01938">
        <property type="entry name" value="TRAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05958">
        <property type="entry name" value="tRNA_U5-meth_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51687">
        <property type="entry name" value="SAM_MT_RNA_M5U"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50926">
        <property type="entry name" value="TRAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01231">
        <property type="entry name" value="TRMA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4 6" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 4 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="TRAM" evidence="5">
        <location>
            <begin position="7"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="4">
        <location>
            <position position="396"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="272"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="301"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="325"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="369"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PJN13153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="443" mass="47962" checksum="DDB1CB71787407BE" modified="2018-04-25" version="1">MQAEPKKSLVGEEYEVEIGPVAHGGHCIARTDEGQVLFVRHALPGEKVVARVTDGEEGARFLRADAVTVIEASKDRVEAPCPYAGPGRCGGCDWQHAKPGAQRRLKGEVIAEQLQRLAGLTPEEAGWDGTVMPAEGDKLPAGEVPQWRTRVQYAVDPDTGKAGLRRHRSHEVEPVEHCMIAAPGVSELGIEKRDWTGMESIEAIAATGSQDRQVILTPRPGARLPLVELDKPVSVLRVDEKDGGIHRVHGRGFVRERADGRTHRVGSGGFWQVHPQAADTLVKAVMQGLLPRKGEMALDLYCGVGLFAGAIADRIGDEGAVLGIESGKRAVEDARHNLAAFDRVRIEQGKVETVLPRTGITEVDLIVLDPPRAGAGKKTVEHLASLGARRIAYVACDPAALARDLAYFRDGGYKVRMLRAFDLFPMTHHVECVAVLEPVKKDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K2M4</accession>
    <name>A0A2M9K2M4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_01995</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000001">
        <property type="protein sequence ID" value="PJN13373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN13373">
        <property type="protein sequence ID" value="PJN13373"/>
        <property type="gene ID" value="CG723_01995"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="36"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="61"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="92"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN13373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="497" mass="51149" checksum="F33019D2FB8DBB70" modified="2018-04-25" version="1">MAHAPKAPVDPVRAVAAGLLNLSGLGAGYLLLRRWVLAAVCLAATAALLVLALPAEPEGVPAGLLVGYGLLLLVAALDAARRAATTPLRSPVVATALGIVLLAAPAGGVVAYDAARDDAVEEMLLGRLDDADALVAKAAARTSFAEGRGDYTTALARYRELAHDHAGSKAAGLVPDRLDAYYRAVAKPYTDKKDCEAIEPLTYLRAVPGKGMDRDVLGSLATWPDKPLAASLYACGTTKLGTESAGSEGGELGRLLRTFPKSEQAGQVAGALRDAVAARDRSLGGAEPCTATDELRSIGETAGALPDDAGAGVATDVDKGVEKGVYACGVDEFKDKKFGDARKTLADFADTYKNSRNRARAEDIAIAAEIAGVRPAAGNRLPPAGSPGGTRMTLVVTNDGPGPVEVLYTGPVTGSVKLAACGSCTMYASESAGRSKACKASRTYPKATIRLPAGRYHFLHKHSADTTAAISDRAAGSEIRPGYSYTQCSYVVRGGGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K335</accession>
    <name>A0A2M9K335_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Amino acid permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CG723_02925</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CB01635</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000001">
        <property type="protein sequence ID" value="PJN13529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN13529">
        <property type="protein sequence ID" value="PJN13529"/>
        <property type="gene ID" value="CG723_02925"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="27"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="60"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="101"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="140"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="172"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="204"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="244"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="287"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="338"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="370"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="405"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="430"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PJN13529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="461" mass="47744" checksum="C264B93E9CB7308A" modified="2018-04-25" version="1">MPHTGTVTKPAPAPQHEELSSKHARRFGLPIATALVMGNIIGGGIFLLPASVAPFGTISLVAFGVLTVGAIALALVFGRLAHRHPQTGGPYVYAREAFGDFAGFLASWSYWITTWVSNAALAVAAVGYLDVLLPIHGSTFWTIVAALTVQWLPALANLAGTRYVGAVQLVSTVLKFAPLLLVAVGGLFFFHADNLGPFRASGDSSLGAVSASAAILLFSYLGVESASVSAGEVRDPERNVGRATVLGTGLAALLYLLCTLAVFGTVAHDRLVDSSAPFSDAVNAMFGGTWGGTAVAVAALVSMLGALNGWTLLSAQTPYAAAKDGLFPAVFTKKKRGIPTAGVLVAVTLASLLTVYNYTAGSAGVFETLVLVTTFTATVPYLLATAAQIYFLLSGQGHRVSGPRLARDLVLALAAFGFSLWLVGGAGYAAVYQGVLFLFAGVLVYAWMAARKKRTAADATD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K351</accession>
    <name>A0A2M9K351_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">2-dehydropantoate 2-reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CG723_03060</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CB01635</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ketopantoate reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000001">
        <property type="protein sequence ID" value="PJN13554.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN13554">
        <property type="protein sequence ID" value="PJN13554"/>
        <property type="gene ID" value="CG723_03060"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013752">
        <property type="entry name" value="KPA_reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013332">
        <property type="entry name" value="KPR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02558">
        <property type="entry name" value="ApbA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08546">
        <property type="entry name" value="ApbA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="SSF48179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ApbA" evidence="2">
        <location>
            <begin position="3"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="domain" description="ApbA_C" evidence="3">
        <location>
            <begin position="197"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02558"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PJN13554.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="325" mass="34380" checksum="EF8583C18E162957" modified="2018-04-25" version="1">MKVAVLGAGAIGAYVGAALHRAGADVHLVARGPHLAAMRQHGVQVRSPRGDFTARANATDDPSGIGPVDYVFLGLKANSYAACGPLIEPLLHSSTAVIAAQNGIPWWYFHRHGGPHDGQRIESVDPGGAVSAVLAPQRAIGCVVYAATELEGPGVVRHLEGTRFSIGEPDRSVSDRCLAFSQAMQAGGLKCPVEPELRGDIWIKLLGNISFNPISALSRATMRQMCLHGGTRRVIEIMMTETLAVAGALGCRPDISVERRLAGAERVGDHRTSTLQDLERGKPLELDVLLAAVVELAEITGVPVPTLRTVHAISDLLADRMRSAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K380</accession>
    <name>A0A2M9K380_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">HTH tetR-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CG723_03235</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000001">
        <property type="protein sequence ID" value="PJN13586.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN13586">
        <property type="protein sequence ID" value="PJN13586"/>
        <property type="gene ID" value="CG723_03235"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039538">
        <property type="entry name" value="BetI_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13977">
        <property type="entry name" value="TetR_C_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0678">Repressor</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="4">
        <location>
            <begin position="96"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="2">
        <location>
            <begin position="119"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="65"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="81"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PJN13586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="286" mass="30973" checksum="4173DA75E99ACCB2" modified="2018-04-25" version="1">MAMARPSRQVRDLCSCWLKGATCLGRGLTGEGPVRRKVMPLCCVGGHNNSLLWAGIGVRQWPIPEGPVPGRPAPERPAQRRGAGMGEKESGGDAGEVQRERILRSAALVMAERGFDAARMRDVARGAGVSIGLLQHYFDTRDLLFREAFEWSIGELIARWRKGASAEPDPWRRFELLVRELADDPDLQRRCATWTEFCASAARRPELRDGVRRAHEDWRELVLGIAESGVAAGTFVPVVSIDVAVRSVLAAVDGCDMAVASGSGMGAEGYAAVILATARSVLGVRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K3F3</accession>
    <name>A0A2M9K3F3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Heme ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CG723_03655</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000001">
        <property type="protein sequence ID" value="PJN13653.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN13653">
        <property type="protein sequence ID" value="PJN13653"/>
        <property type="gene ID" value="CG723_03655"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="5"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="344"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="58"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="37"/>
            <end position="44"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="382"/>
            <end position="389"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PJN13653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="547" mass="58832" checksum="7F7AB2BE8B2B636D" modified="2018-04-25" version="1">MTATLVAKNLAAGHGDRSLFSGLDLVVAPGDVIGLVGANGAGKSTLLKLLAGLDTPEQGELRLSPPGATVGHLPQEPERRPGETVREFLARRTGVDAAQRAMDEATQALVDGAPGADDAYSVSLERWLDLGGADLDERAEEVTGSLGLGVGLDQEMASLSGGQAARAGLASLLLSRYDVFLLDEPTNDLDLDGLERLESFVRGLRAGTVVVSHDREFLTRTVTKVLELDLAQQEINLYGGGYEAYLEEREVARRHARDEFDEYADKKAALEGRAQMQRGWMDKGVKNARRKATDNDKIGRKFRSEASEKQAAKARQTQRMIERLDAVDEPRKEWELRMEIAAAPRSGAVVATLRDAEVRRGDFTLGPVSLQIDWADRIAITGANGAGKSTLLGALLGREPLDAGHATLGSGVVVGEVDQARALFHGSESLLDAFCAAVPDTEPAEVRTLLAKFGLKADHVLRSAATLSPGERTRAALALLQGRGVNLLVLDEPTNHLDLPAIEQLESALDSYEGTLLLVTHDRRMLDAVRTQRRLEVANGKVTELSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K3L9</accession>
    <name>A0A2M9K3L9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_00705</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000001">
        <property type="protein sequence ID" value="PJN13726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN13726">
        <property type="protein sequence ID" value="PJN13726"/>
        <property type="gene ID" value="CG723_00705"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043917">
        <property type="entry name" value="DUF5753"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19054">
        <property type="entry name" value="DUF5753"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="22"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN13726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="280" mass="31349" checksum="A6435FEA12B2E4A1" modified="2018-04-25" version="1">MPQRRVVTGRSQEPRQRFAEELRTLRAGSGTSLRQLGERLGWDYSLFGKMEKGETLGSPEVVQALDQHYGTPGLLLALWELAAGDHTQFRERYRRYMALEAEAVSLWHFAVSVLPGLLQTPGYAREVLAAGGLRGKELEQQVEARMGRRELLEGEDAPPFRTILSEAVLRTPLREVAQWRRQLEYVAEVAERPTVTMQVLPLSAGMHGLDSTALMFLRLPGGLTVAYTENAHRGELIEAHSPVERLQRAYDAMRDLALSPAESRNFVLATLEEVPCEAST</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JEK5</accession>
    <name>A0A2M9JEK5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CG723_45525</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000056">
        <property type="protein sequence ID" value="PJN05309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN05309">
        <property type="protein sequence ID" value="PJN05309"/>
        <property type="gene ID" value="CG723_45525"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PJN05309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="233" mass="25944" checksum="416E4222A9927F33" modified="2018-04-25" version="1">MYAHHFPPVDLPGLEWLRNVNGDRAAALEQFVTGWYPAAGATEPPATCAPSRLPAGLRQLYRLAKQRSGALGTQNRILPEPDLHTDHLGEMLVFGVENQGGFLWSLLWTLDGPEADPTVWFREFDEEPIAEQEPLSGFLIQFSLFEASMGADYLALPRRLTATQVAQLTQALHPVPLRPFWPWAPTHFYVAPGLVVHVSNEVGEEFDVWAGATHRSALEPLADLPVDWTRFDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JF99</accession>
    <name>A0A2M9JF99_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">LMWPc domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_43990</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000045">
        <property type="protein sequence ID" value="PJN05568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN05568">
        <property type="protein sequence ID" value="PJN05568"/>
        <property type="gene ID" value="CG723_43990"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023485">
        <property type="entry name" value="Ptyr_pPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036196">
        <property type="entry name" value="Ptyr_pPase_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01451">
        <property type="entry name" value="LMWPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00226">
        <property type="entry name" value="LMWPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52788">
        <property type="entry name" value="SSF52788"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LMWPc" evidence="1">
        <location>
            <begin position="41"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN05568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="288" mass="29703" checksum="2DF3F389DE6249ED" modified="2018-04-25" version="1">MRVVDTHVKDVSDLVQTVFSGLSPLVIEDVADEGERIVVRARTPQGTAVCPVGGASSGRVHGSHLRTAAVDKWVGSTAHPDMIKAAAARGGYDLNDHRPMQVDKAALAWPDVILAMDQSVLDKLMLLGGDENAHKMQRYLDGQDVPDPMGKAMDAFTACAQIIEEGAARYLPCPPATDSTRSVSCSAASGRPCARARTAISVRLASCASSGATASRNRSGVTSPIRATAAPACSRWAALCACSLPAEEASGTSTDALPSAVSSAMVPAPLREMTTSASASRSGSSGPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JFL9</accession>
    <name>A0A2M9JFL9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_43500</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000043">
        <property type="protein sequence ID" value="PJN05678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN05678">
        <property type="protein sequence ID" value="PJN05678"/>
        <property type="gene ID" value="CG723_43500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014683305" evidence="2">
        <location>
            <begin position="29"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="48"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="124"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN05678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="263" mass="25317" checksum="1F03707C0A2D7C47" modified="2018-04-25" version="1">MRRASIRGRRGALTGATAAVVCLGGLLAACGSSGGGDGYVAVGAAGATPERTPGRTVAPTGDVELVPLDGADPDPPVPSEGGTGGAEGGGGKSPGGDGSSGDTGAGAEARTDGGSGASEAPGPDGSGSPSTGGSGAGGSAGGSPGGGSTTTPSAPDTGTPSGPAALKVGDPEREAADKRWCEDVTLDMVNTGGTAVRSGTVTFGTHIIGALGIDWATVESTQDLPVPIDAGKRKKKTWTVCVDAWRVPLGMHVETRDVSVKWK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JFW8</accession>
    <name>A0A2M9JFW8_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Cytidylate kinase</fullName>
            <shortName evidence="8">CK</shortName>
            <ecNumber evidence="8">2.7.4.25</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Cytidine monophosphate kinase</fullName>
            <shortName evidence="8">CMP kinase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">cmk</name>
        <name evidence="10" type="ORF">CG723_42825</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CB01635</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>ATP + CMP = ADP + CDP</text>
            <dbReference type="Rhea" id="RHEA:11600"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58069"/>
            <dbReference type="ChEBI" id="CHEBI:60377"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.25"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 8">
            <text>ATP + dCMP = ADP + dCDP</text>
            <dbReference type="Rhea" id="RHEA:25094"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57566"/>
            <dbReference type="ChEBI" id="CHEBI:58593"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.25"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the cytidylate kinase family. Type 1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.25" evidence="8"/>
    <dbReference type="EMBL" id="NNBL01000041">
        <property type="protein sequence ID" value="PJN05771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN05771">
        <property type="protein sequence ID" value="PJN05771"/>
        <property type="gene ID" value="CG723_42825"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036430">
        <property type="term" value="F:CMP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036431">
        <property type="term" value="F:dCMP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006220">
        <property type="term" value="P:pyrimidine nucleotide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02020">
        <property type="entry name" value="CMPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00238">
        <property type="entry name" value="Cytidyl_kinase_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003136">
        <property type="entry name" value="Cytidylate_kin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011994">
        <property type="entry name" value="Cytidylate_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02224">
        <property type="entry name" value="Cytidylate_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00017">
        <property type="entry name" value="cmk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 8 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Cytidylate_kin" evidence="9">
        <location>
            <begin position="17"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="21"/>
            <end position="29"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009427"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PJN05771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="234" mass="23881" checksum="7A290DF8DDA6A9A9" modified="2018-04-25" version="1">METAATAASAAPAAVIVAIDGPSGTGKSSTSKAVAAQLGLSYLDTGAQYRAITWWMVNNGIDLTDPTAIAAVAGKAEIVSGTDPSAPTITVDGVDVAAPIRTTEVTSKVSAVSAVPEVRARITELQRSIAASAELGIVVEGRDIGTTVLPDADLKIFLTASPEARAARRSGELKGADVKATQEALIKRDAADSSRKTSPLAKAGDAVEVDTSELTLQQVIECVVTLIGEKRAAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JGK9</accession>
    <name>A0A2M9JGK9_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Peptidase_M48 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CG723_41740</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CB01635</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="6">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the peptidase M48 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000037">
        <property type="protein sequence ID" value="PJN05972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN05972">
        <property type="protein sequence ID" value="PJN05972"/>
        <property type="gene ID" value="CG723_41740"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001915">
        <property type="entry name" value="Peptidase_M48"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01435">
        <property type="entry name" value="Peptidase_M48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 6" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="1 6" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4 6" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="34"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="89"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="287"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M48" evidence="8">
        <location>
            <begin position="127"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PJN05972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="311" mass="33592" checksum="0EEC9ABD3E0557D1" modified="2018-04-25" version="1">MTVPVALLLLGTLAAVLAPRLLARAEWPEREPVVALWVWQCVVAGVLLCCALSMTLSAAAAWQAVRGHVFASAPHAVVDAYALRAAGGWAATLAVTLALGGLWTAAMLAREIFRSGAGRRQRRAELLVRSPLLPGEEPGSDRLVVLEGERPDAWWLPGAAPQLVVTTAALRRLKGRQLDAVLAHEMGHAQWRHDWLLHCSGALATGFPQVPVFAAFRDEMHRLVELAADDMASRRFGRLTIALALVELNEDRGVFGPCPTPQAHVPQRVHRLLTPPRRLTPARRLRLTAAAALVPVVPLLVTFVPGLRALG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JGP0</accession>
    <name>A0A2M9JGP0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">AsnC family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CG723_41900</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000037">
        <property type="protein sequence ID" value="PJN06002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN06002">
        <property type="protein sequence ID" value="PJN06002"/>
        <property type="gene ID" value="CG723_41900"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000485">
        <property type="entry name" value="AsnC-type_HTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019888">
        <property type="entry name" value="Tscrpt_reg_AsnC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019887">
        <property type="entry name" value="Tscrpt_reg_AsnC/Lrp_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01037">
        <property type="entry name" value="AsnC_trans_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00033">
        <property type="entry name" value="HTHASNC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00344">
        <property type="entry name" value="HTH_ASNC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50956">
        <property type="entry name" value="HTH_ASNC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH asnC-type" evidence="4">
        <location>
            <begin position="3"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PJN06002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="160" mass="17463" checksum="B05EC43690F674A9" modified="2018-04-25" version="1">MAVDELDTRILRLLLERPRTSVREYARILGVARGTLQARLDRLERDGVITGTGPALSPTALGHPVLAFVHIEVTQGHLEDVGDALAGVPEIIEAFSITGGGDLLTRVAARDNGHLEDIIQQLNRLPGVVRTRTEVALRERVPHRILPLVEAIGRAAAERR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JHI0</accession>
    <name>A0A2M9JHI0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Sugar ABC transporter substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_40055</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000033">
        <property type="protein sequence ID" value="PJN06217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN06217">
        <property type="protein sequence ID" value="PJN06217"/>
        <property type="gene ID" value="CG723_40055"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006059">
        <property type="entry name" value="SBP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01547">
        <property type="entry name" value="SBP_bac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014618160" evidence="1">
        <location>
            <begin position="28"/>
            <end position="422"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN06217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="422" mass="47031" checksum="7675C23B3F72461F" modified="2018-04-25" version="1">MSRRGLLRGAAVGAGALTLPALLTACGDGPGGDKKTVTVGSNSSDAVPKKAFAAAFTAYEKKSGKKVDVNTTDHNEFQTNITRYLQGTPDDVFMWFAGYRMQYFAEKGLLTDVDDVWKGFKGFSQALKDQSTHDGKQYFVPYYYYPWAVFHRKSLFEKKGYEQPKNWDDFIALAKQMHKDGTPVAFCDKDGWPAMGTFDYINMRLNGYDFHKGLMAGTEAWTDTKVKKVFDLWRELMPYYQKGALGRTWEEAAQGLQKRQTGMAVFGMPHPGQQFPENERADIDFFAFPEIDPQYGQDAVEAPIDGFLIAKKAKNVDAGKALLKYLGTPGAEDIYLAGDPNNVAVNDGADTSKYTPLQKKSAELVSGAKQISQFMDRDTRPDFAQTVMIKALQDFIGNPNDVDGLVNRIERQKKEIFSSAVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JHM7</accession>
    <name>A0A2M9JHM7_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">YkuD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CG723_39670</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000031">
        <property type="protein sequence ID" value="PJN06379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN06379">
        <property type="protein sequence ID" value="PJN06379"/>
        <property type="gene ID" value="CG723_39670"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005490">
        <property type="entry name" value="LD_TPept_cat_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03734">
        <property type="entry name" value="YkuD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014721789" description="YkuD domain-containing protein" evidence="2">
        <location>
            <begin position="28"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="domain" description="YkuD" evidence="3">
        <location>
            <begin position="94"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="29"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PJN06379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="248" mass="26172" checksum="37FD716379E720BF" modified="2018-04-25" version="1">MRNAGAVRTAVAAAACSVLLMTLSACGGSSGGDGTGRKAGPGSAGTRQEDRPAVDLKRIPDVGDQLQSKIPQNAGQVIAVYGDGKNSGDSTVVLYTKSGSTWDKTHSWPAHNGKKGWTADHREGDKRSPIGVFTLTDAGGVLADPGAKLPYTQATSFQAPHYWAKSHWHDFDYVIAIDYNRVKGTAPNDPTRPEGQTKGGSIWLHMDHGSGTSACVSLSKSGMEYLLRTIDPKQHPVVVMGDKASLKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-06-02" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JI27</accession>
    <name>A0A2M9JI27_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">AI-2E family transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CG723_38230</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CB01635</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the autoinducer-2 exporter (AI-2E) (TC 2.A.86) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000028">
        <property type="protein sequence ID" value="PJN06546.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN06546">
        <property type="protein sequence ID" value="PJN06546"/>
        <property type="gene ID" value="CG723_38230"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002549">
        <property type="entry name" value="AI-2E-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21716">
        <property type="entry name" value="PTHR21716"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01594">
        <property type="entry name" value="AI-2E_transport"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="161"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="247"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="301"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="332"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="363"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="400"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="444"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="16"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PJN06546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="467" mass="49324" checksum="0126B290A9FE8E05" modified="2018-04-25" version="1">MSRVPGWLGRLGSELSRMGERLDERRAEAERDDRGDDPVPDAATGSAPQPARDAAHAAAEVPQVPVTRPENGGGDHVPPPPAYAPAIAARPDPVAAVPWGMRVAAEAGWRLLVLAGTLWVLMRVISAVQLVVYAFVAAMLITALLQPTVARLRRHGVPRGLATALTAILGFVIMGLVGWFVVWQVQENIDNLSDQIQDGIDELRNWLLNSPFHVTESQINEIAKSLRDAVGANTDQITSAGLEGVTVIVEALTGILLTMFSTLFLLYDGRRIWEWTTRLVPAQARPGIAGAGPRAWRTLTAYVRGTVIVALIDAIFIGLGIFFLGVPMAVPLAVFIFLFAFIPLVGAVISGALAVVVALVTQGVFTAVMTLAVVLAVQQIEGHILQPFILGRAVRVHPLAVVLSVAAGGLVNGIGGAVVAVPLVAVTNTVVGYLRSYSREAALRQSPPPHGATAVDVAPVDPTAGKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JI92</accession>
    <name>A0A2M9JI92_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CG723_38550</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000028">
        <property type="protein sequence ID" value="PJN06601.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN06601">
        <property type="protein sequence ID" value="PJN06601"/>
        <property type="gene ID" value="CG723_38550"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PJN06601.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="312" mass="33756" checksum="3CF1620B5677F6F5" modified="2018-04-25" version="1">MWVAVIGVVGAVVAAAVGAVIAAWATLRARRRQDGVISVFDVTVMDAETVLAERDADAHVLGELVPERPVLDIVVRNGGDLDGVVRRVQVDVEGLLHVPPIDLPFVLVLPGATITAPLPAQQRSMGPSAAYAVNFPLREGSYRHSINQLIPAGTADRFVVSLVAAEAERGRDFYGVSLTLDCGRSKKGRATTAWESVRVLAYGPPVWESPDEIRQRLSRMADRVRELAPSGGDSVGVLFNSTVHPARTAMDDYVTVYENKLKVLVAALGECQKYAADETRIRTWLTELERATEEIEPLRHHATALRASGGHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-06-02" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JIB6</accession>
    <name>A0A2M9JIB6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Diguanylate cyclase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_38615</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000028">
        <property type="protein sequence ID" value="PJN06610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN06610">
        <property type="protein sequence ID" value="PJN06610"/>
        <property type="gene ID" value="CG723_38615"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd01949">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000160">
        <property type="entry name" value="GGDEF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00990">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00267">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="SSF55073"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00254">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50887">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GGDEF" evidence="2">
        <location>
            <begin position="219"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="350"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="368"/>
            <end position="383"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN06610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="383" mass="40493" checksum="C55B9F4FBBCA224E" modified="2018-04-25" version="1">MGEEVRLRAVVAMAQGMAAAQSPRESWRAAALGACRALSGTFAALSVWERERGRLRVLVNVGECAEGEVEFPEDEAYPVHQFPEITEFLHEQWVGGGAPRAWVETAAGTVEGGGYCHQRVAALRRRGRGCCVVAPIVLHGRAWGELYVARPVGAEVFGAHDAAFATVLAAVAAAGIAQTERLEEARRLAFTDALTGLANRRAVDMRLDEAIERHRVGGDVVSLVVCDLNGLKRVNDSLGHAVGDRLLERFGSVLSLCGAMLPGTLAARLGGDEFCLVAVGPDADDVVRAGEELCLRASELELGEGVACGIASTGDPIGEVLSARRLFRLADAAQYRAKALRAVKPVVAGRDGPDDPVVRLADSPPPAVGDSERRRLRGRGAGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JIC3</accession>
    <name>A0A2M9JIC3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Carbohydrate kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_38425</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000028">
        <property type="protein sequence ID" value="PJN06618.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN06618">
        <property type="protein sequence ID" value="PJN06618"/>
        <property type="gene ID" value="CG723_38425"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011611">
        <property type="entry name" value="PfkB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00294">
        <property type="entry name" value="PfkB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="SSF53613"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PfkB" evidence="1">
        <location>
            <begin position="2"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN06618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="336" mass="34629" checksum="D35F0D4214347D4E" modified="2018-04-25" version="1">MDVVTLGESMVTFVPSVPGRLADVPSFDRGIGGAESNVACVLAAAGHTVRWVSRVGADGFGDHLVDTIGAYGVDTSAVRRDPARPTGIYFRTAGDRATDAHEVAYYRAGSAASAMSSQNMDLAAIRSGRVLHLSGITPALSPGCLDLTADLTARIAAGRPLVSFDVNHRPGLWPRPDDARVLLDLARGADLVFVGEDEAEDAWGITGGPDAIRAALPEPATLVVKRGADGAVAYDEHGVRHTEPAPRVDVVAAVGAGDAFAAGYLSGALRGLPVPARLRHGHLMAAAALTTPGDLAAPPSRAHADRLADLDGASWGTLHLGPGWTADGAVEEVRTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JIG6</accession>
    <name>A0A2M9JIG6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Lipase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_37750</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000027">
        <property type="protein sequence ID" value="PJN06633.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN06633">
        <property type="protein sequence ID" value="PJN06633"/>
        <property type="gene ID" value="CG723_37750"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002918">
        <property type="entry name" value="Lipase_EstA/Esterase_EstB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32015">
        <property type="entry name" value="PTHR32015"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01674">
        <property type="entry name" value="Lipase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014896378" evidence="1">
        <location>
            <begin position="33"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN06633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="288" mass="30107" checksum="C02CE1E694EE0D67" modified="2018-04-25" version="1">MLPRNWKRAVRSLTAALLLTAVAGAVPAAAHADTAVSSGWNNYACKPSAAHPRPVVLVHGTFGNSVDNWLVLAPYLVNRGYCVFSLDYGQLPGVPLFYGLGPIDKSAGQLDTFVDKVLAATGAPKADLVGHSQGGMMPRYYLKFLGGAAKVNSLVGVAPDNHGTTLNGLTNLLPYFPGVGDLLTLATPGLADQMAGSPFITKLNQGGDTVPGVHYTVIATKYDEVVTPYGTQFLSGPDVRNVKLQDLCSVDLSEHVAIGTIDRVAFHEVANALDPAHATPTTCASAVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JJ95</accession>
    <name>A0A2M9JJ95_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CG723_36160</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000024">
        <property type="protein sequence ID" value="PJN06939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN06939">
        <property type="protein sequence ID" value="PJN06939"/>
        <property type="gene ID" value="CG723_36160"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PJN06939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="79" mass="8404" checksum="D611AF1FD778A88D" modified="2018-04-25" version="1">MASPIRNGSSVRVLFGHGHTLVVEQDTFASMTVDEVIARFHLAADPLYGRAGSQAIVGRIDELDRSPSLCGLPRALQAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JJN3</accession>
    <name>A0A2M9JJN3_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">NADH-quinone oxidoreductase subunit D</fullName>
            <ecNumber evidence="5">7.1.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">NADH dehydrogenase I subunit D</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">NDH-1 subunit D</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">nuoD</name>
        <name evidence="8" type="ORF">CG723_35745</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CB01635</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a quinone + 5 H(+)(in) + NADH = a quinol + 4 H(+)(out) + NAD(+)</text>
            <dbReference type="Rhea" id="RHEA:57888"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="5">NDH-1 is composed of 14 different subunits. Subunits NuoB, C, D, E, F, and G constitute the peripheral sector of the complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Peripheral membrane protein</topology>
            <orientation evidence="5">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 6">Belongs to the complex I 49 kDa subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.1.1.-" evidence="5"/>
    <dbReference type="EMBL" id="NNBL01000023">
        <property type="protein sequence ID" value="PJN07086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN07086">
        <property type="protein sequence ID" value="PJN07086"/>
        <property type="gene ID" value="CG723_35745"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050136">
        <property type="term" value="F:NADH dehydrogenase (quinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.645.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01358">
        <property type="entry name" value="NDH1_NuoD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001135">
        <property type="entry name" value="NADH_Q_OxRdtase_suD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014029">
        <property type="entry name" value="NADH_UbQ_OxRdtase_49kDa_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022885">
        <property type="entry name" value="NDH1_su_D/H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029014">
        <property type="entry name" value="NiFe-Hase_large"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11993">
        <property type="entry name" value="PTHR11993"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00346">
        <property type="entry name" value="Complex1_49kDa"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56762">
        <property type="entry name" value="SSF56762"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00535">
        <property type="entry name" value="COMPLEX1_49K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 5 6" id="KW-0520">NAD</keyword>
    <keyword evidence="2 5" id="KW-0874">Quinone</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5 6" id="KW-1278">Translocase</keyword>
    <keyword evidence="1 5 6" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Complex1_49kDa" evidence="7">
        <location>
            <begin position="134"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="domain" description="Complex1_49kDa" evidence="7">
        <location>
            <begin position="309"/>
            <end position="383"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PJN07086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="383" mass="42600" checksum="EB4D0257E2B37E3F" modified="2018-04-25" version="1">MTPTTETTVGIGGAAETTDMVLNIGPQHPSTHGVLRLRLVLDGERIQQAEPVIGYMHRGAEKLFEARDYRQIVMLANRHDWLSAFSSELGVVLAVERMLGMEVPERAVWLRTLLAELNRVLNHLMFLGSYPLELGGITPVFYAFREREELQNVMEEMSGGRMHYMFNRVGGLKEDVPAGWTTRAREAVASVRSRMGVYDDLVLGNEIFRGRTRDVGVLSPEAVHSYGVSGPIARASGVDFDLRRDEPYLAYGELQDTLKVVTRSEGDCLARFEVLLEQTHNALDLADACLDRLAELPPGPVNQRLPKVLKAPEGHTYAWTENPLGINGYYLVSKGEKTPYRLKLRSASYNNIQALTELLPGTLVSDMVAILGSLFFVVGDIDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JJS6</accession>
    <name>A0A2M9JJS6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">SAM-dependent methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_35985</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000023">
        <property type="protein sequence ID" value="PJN07126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN07126">
        <property type="protein sequence ID" value="PJN07126"/>
        <property type="gene ID" value="CG723_35985"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransf_11" evidence="1">
        <location>
            <begin position="47"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN07126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="257" mass="27514" checksum="486DABB2B0F2F5DD" modified="2018-04-25" version="1">MTTASRAHSFNIAAAQYAANRPSYPPALLDAVEEAAGRPLAGARVADVGAGTGISTALLHARGARVVAVEPGDGMALEFRQTLPAVPIVRGDGNALPLADASLDLLTYAQSWHWTEPARSAPEAMRVLRPGGALALWWNTVALDIPWIAAQHERIARHVGVETGARQRPDEARATELSGLTALPGRGEVTLRHVRWSRHVPLDTHLANIGSHSAFLVLEEGDAQAFLTEERARVGELFPDGTVEETYVVELLVAIRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JJW3</accession>
    <name>A0A2M9JJW3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Coenzyme F420 biosynthesis-associated protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CG723_35650</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000023">
        <property type="protein sequence ID" value="PJN07067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN07067">
        <property type="protein sequence ID" value="PJN07067"/>
        <property type="gene ID" value="CG723_35650"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.150.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022454">
        <property type="entry name" value="CHP03883_F420-assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018766">
        <property type="entry name" value="Zinicin_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042271">
        <property type="entry name" value="Zinicin_2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39420">
        <property type="entry name" value="PTHR39420"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10103">
        <property type="entry name" value="Zincin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03883">
        <property type="entry name" value="DUF2342_F420"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03624">
        <property type="entry name" value="TIGR03624"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PJN07067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="380" mass="41652" checksum="14F789E71D38D0EE" modified="2018-04-25" version="1">MTSIGGASGMVDWNLAVATATRLVRPGPEVSRDEARAIVAELRRHAKASEEHVRGFTRMATEEVHDTPVLVVDRPGWVRANVAGFRELLKPLLDKMEERRGSGPGGAVLGAVGGKVTGVELGMLLSFMSSRVLGQYETFAPATRDLPAAPNGGGRLLLVAPNIVHVERELDVNPHDFRLWVCLHEETHRTQFTAVPWLRDHLEGEIQSFLAETDVDPMTFLERIREAAQSLAGARPEGEQGEGDDGGRSLVELVQSPAQREILARLTAVMSLLEGHADFVMDGVGPAVVPSVGEIREKFKERRQKGASRLDLALRKLLGLDAKLRQYRDGERFVRAVVNEVGMDGFNRVWTSPNTLPTKAEIAKPADWVARVHRKSEGAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JJY9</accession>
    <name>A0A2M9JJY9_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HATPase_c domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_34825</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000022">
        <property type="protein sequence ID" value="PJN07172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN07172">
        <property type="protein sequence ID" value="PJN07172"/>
        <property type="gene ID" value="CG723_34825"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13581">
        <property type="entry name" value="HATPase_c_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HATPase_c" evidence="1">
        <location>
            <begin position="12"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN07172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="144" mass="15602" checksum="9642E1C03C605E75" modified="2018-04-25" version="1">MADHQEASVTLPSDPASVSSARTYVGDVLAEWGMPRDAETADTVRLIVSELATNAVMHTRGQSPVFTVDVQLERDEHLRIGVTDSHPRYPKRLPAAVQQDNGRGMVIIRCLTSECGGSLSVRPTPEGGKTVWIALPWTVPVQSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JK52</accession>
    <name>A0A2M9JK52_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">EamA family transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CG723_35240</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000022">
        <property type="protein sequence ID" value="PJN07246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN07246">
        <property type="protein sequence ID" value="PJN07246"/>
        <property type="gene ID" value="CG723_35240"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000620">
        <property type="entry name" value="EamA_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00892">
        <property type="entry name" value="EamA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="50"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="76"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="108"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="135"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="167"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="193"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="224"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="257"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="290"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="312"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="3">
        <location>
            <begin position="55"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="3">
        <location>
            <begin position="194"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PJN07246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="341" mass="35421" checksum="1C415A9711A5B98F" modified="2018-04-25" version="1">MSTVASSSPPATPAPAPSEISADNPASSPSEIPTGSPASARPRRALDWRVRFGVLSLIWGFSFLLIKVGTEGYAPFQVTLGRLAFGTAVLAVAMAVKRERLPRGLRTWGHIAVAALLLNSLPFSLFAFSEQTIPSTLAGICNATSPLWGMALSLVALSEDRPTRRRVAGLGIGFLGVLTVLGVWQGFHGLDLAGTAMALLASLSYPVGWIYLRRTLAGTGHSNLSLSGAQLLMATVQLAVVTPLFTTLPAHLPVVPLLAIVALGALGTGLAFLIQYGLVAEIGPTTAQMVTYFIPVIATAAGVALLGESLTWSTPIGAVIVLAGAALTQSRARTPRRSAQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JKC0</accession>
    <name>A0A2M9JKC0_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 8">Methionyl-tRNA formyltransferase</fullName>
            <ecNumber evidence="4 8">2.1.2.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">fmt</name>
        <name evidence="11" type="ORF">CG723_34225</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CB01635</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 8">Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>(6S)-10-formyltetrahydrofolate + L-methionyl-tRNA(fMet) = (6S)-5,6,7,8-tetrahydrofolate + H(+) + N-formyl-L-methionyl-tRNA(fMet)</text>
            <dbReference type="Rhea" id="RHEA:24380"/>
            <dbReference type="Rhea" id="RHEA-COMP:9952"/>
            <dbReference type="Rhea" id="RHEA-COMP:9953"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="ChEBI" id="CHEBI:57454"/>
            <dbReference type="ChEBI" id="CHEBI:78530"/>
            <dbReference type="ChEBI" id="CHEBI:78844"/>
            <dbReference type="EC" id="2.1.2.9"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the Fmt family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.2.9" evidence="4 8"/>
    <dbReference type="EMBL" id="NNBL01000021">
        <property type="protein sequence ID" value="PJN07312.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN07312">
        <property type="protein sequence ID" value="PJN07312"/>
        <property type="gene ID" value="CG723_34225"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004479">
        <property type="term" value="F:methionyl-tRNA formyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd08646">
        <property type="entry name" value="FMT_core_Met-tRNA-FMT_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd08704">
        <property type="entry name" value="Met_tRNA_FMT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00182">
        <property type="entry name" value="Formyl_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005794">
        <property type="entry name" value="Fmt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005793">
        <property type="entry name" value="Formyl_trans_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002376">
        <property type="entry name" value="Formyl_transf_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036477">
        <property type="entry name" value="Formyl_transf_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011034">
        <property type="entry name" value="Formyl_transferase-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044135">
        <property type="entry name" value="Met-tRNA-FMT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041711">
        <property type="entry name" value="Met-tRNA-FMT_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02911">
        <property type="entry name" value="Formyl_trans_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00551">
        <property type="entry name" value="Formyl_trans_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50486">
        <property type="entry name" value="SSF50486"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53328">
        <property type="entry name" value="SSF53328"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00460">
        <property type="entry name" value="fmt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 8 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Formyl_trans_N" evidence="9">
        <location>
            <begin position="2"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="domain" description="Formyl_trans_C" evidence="10">
        <location>
            <begin position="204"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="region of interest" description="Tetrahydrofolate (THF) binding" evidence="8">
        <location>
            <begin position="110"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00016014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PJN07312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="314" mass="32901" checksum="AF90B35C0160CDAD" modified="2018-04-25" version="1">MKLVFAGTPEVAVPALDALIASDRHEVAAVVTRPDAPAGRGRRLVASPVAERAEEAGIEVLKPAKPRDEAFLARLREIAPDCCPVVAYGALLPKVALDVPARGWVNLHFSLLPAWRGAAPVQHAIMAGDEITGASTFLIEEGLDSGPVYGTVTEMVRPTDTSGDLLTRLAFAGAGLLSATMDGIEDGSLKAVAQPVDGITVAPKITVENAHVDWAAPALRVDRVVRGCTPAPGAWTVFRDERLKLIQAVPVPARTDLAPGELAVGKKNLYVGTGSYAVELLWVQAQGKKPMAAADWARGVRIAPGERLGGTDVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JKE7</accession>
    <name>A0A2M9JKE7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">AsnC family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CG723_34430</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000021">
        <property type="protein sequence ID" value="PJN07349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN07349">
        <property type="protein sequence ID" value="PJN07349"/>
        <property type="gene ID" value="CG723_34430"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000485">
        <property type="entry name" value="AsnC-type_HTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019888">
        <property type="entry name" value="Tscrpt_reg_AsnC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019887">
        <property type="entry name" value="Tscrpt_reg_AsnC/Lrp_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019885">
        <property type="entry name" value="Tscrpt_reg_HTH_AsnC-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01037">
        <property type="entry name" value="AsnC_trans_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13404">
        <property type="entry name" value="HTH_AsnC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00033">
        <property type="entry name" value="HTHASNC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00344">
        <property type="entry name" value="HTH_ASNC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00519">
        <property type="entry name" value="HTH_ASNC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50956">
        <property type="entry name" value="HTH_ASNC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH asnC-type" evidence="4">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PJN07349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="146" mass="15962" checksum="F0F7BA73A428A37B" modified="2018-04-25" version="1">MEELDRQIVQLLVKDGRMSYTDLGKATGLSTSAVHQRVRRLEQRGVIRGYAAVVDPEAVGLSLTAFISVKPFDPSAPDDIAERLAGVPEIEACHSVAGDENYILKVRVETPHDLENLLARVRSLAGVSTRTTVVLSTPYEARPPRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JL20</accession>
    <name>A0A2M9JL20_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DUF1775 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CG723_32805</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000019">
        <property type="protein sequence ID" value="PJN07552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN07552">
        <property type="protein sequence ID" value="PJN07552"/>
        <property type="gene ID" value="CG723_32805"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd08545">
        <property type="entry name" value="YcnI_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.2230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012533">
        <property type="entry name" value="YcnI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038507">
        <property type="entry name" value="YcnI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07987">
        <property type="entry name" value="DUF1775"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014942136" description="DUF1775 domain-containing protein" evidence="3">
        <location>
            <begin position="28"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="226"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="domain" description="DUF1775" evidence="4">
        <location>
            <begin position="28"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="164"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="188"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="206"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF07987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PJN07552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="252" mass="26236" checksum="2B3902842EBBF59E" modified="2018-04-25" version="1">MKKISRVAAVGATAASAVLVLSVPAFAHVSVQPEGVAAKGGYAVVNFKVPNERDDAATTKVEVNFPTDHPLASVMPEPIPGWTAKVTKSKLDKPLEMHGEKIDQAVSQVTWTADGSGKDKGIQPGFFQKFPLSIGQLPEDTDELVFKAIQTYDNKEVVRWIEPQAKGQEEPENPAPTLELSAATEDHHGGAAADDSAKSDDDKAATASSSDSSSDGSSDSDTTARALGIAGIVVGAAGVAFGVLAGRRRTNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JL30</accession>
    <name>A0A2M9JL30_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_32975</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000019">
        <property type="protein sequence ID" value="PJN07581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN07581">
        <property type="protein sequence ID" value="PJN07581"/>
        <property type="gene ID" value="CG723_32975"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007165">
        <property type="entry name" value="Phage_holin_4_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37309">
        <property type="entry name" value="PTHR37309"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04020">
        <property type="entry name" value="Phage_holin_4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="38"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="64"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="100"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN07581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="126" mass="13586" checksum="288285FC849676AD" modified="2018-04-25" version="1">MKNFVVKTIANAGALAVAVWLLDKITLTGDSTGKKVGTLIIVALLFGLVNLLVKPIVKLLTFPLFILTLGLITLVVNALMLLLTSWLADQFNQSFHVEGFWTAVLGGLIISVVSWALNVVLPDDKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-05-25" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JL45</accession>
    <name>A0A2M9JL45_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 7">50S ribosomal protein L9</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">rplI</name>
        <name evidence="9" type="ORF">CG723_33055</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CB01635</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Binds to the 23S rRNA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the bacterial ribosomal protein bL9 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000019">
        <property type="protein sequence ID" value="PJN07595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN07595">
        <property type="protein sequence ID" value="PJN07595"/>
        <property type="gene ID" value="CG723_33055"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.430.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.5.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00503">
        <property type="entry name" value="Ribosomal_L9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000244">
        <property type="entry name" value="Ribosomal_L9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009027">
        <property type="entry name" value="Ribosomal_L9/RNase_H1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020594">
        <property type="entry name" value="Ribosomal_L9_bac/chp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020069">
        <property type="entry name" value="Ribosomal_L9_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036791">
        <property type="entry name" value="Ribosomal_L9_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020070">
        <property type="entry name" value="Ribosomal_L9_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036935">
        <property type="entry name" value="Ribosomal_L9_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21368">
        <property type="entry name" value="PTHR21368"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03948">
        <property type="entry name" value="Ribosomal_L9_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01281">
        <property type="entry name" value="Ribosomal_L9_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55653">
        <property type="entry name" value="SSF55653"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55658">
        <property type="entry name" value="SSF55658"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00158">
        <property type="entry name" value="L9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00651">
        <property type="entry name" value="RIBOSOMAL_L9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 7 9" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 7" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="RIBOSOMAL_L9" evidence="8">
        <location>
            <begin position="13"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00029520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00503"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS00651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PJN07595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="148" mass="15799" checksum="AC39E28ECF69C57A" modified="2018-04-25" version="1">MKIILTHEVSGLGTAGDVVDVKDGYARNYLVPRGFAIRWTKGGEQDVAQIRRARKIHEIATIEQANEIKARLEGVKVRLAVRSGDAGRLFGSVTPADVASAIEAAGGPKIDKRRVELGSPIKTLGAHETSVRLHPEVAAKVSVEVVSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JLA5</accession>
    <name>A0A2M9JLA5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_33390</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000019">
        <property type="protein sequence ID" value="PJN07654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN07654">
        <property type="protein sequence ID" value="PJN07654"/>
        <property type="gene ID" value="CG723_33390"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="46"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN07654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="75" mass="8311" checksum="32EF0420F23B73CF" modified="2018-04-25" version="1">MIDRQQGRDQSWEARRPAGIAAFVAGLVVTLAFFAFFPGLPHVIDWGAIVVAVLVGALTRWVCLTWVGKRSRDSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-09-29" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JLP0</accession>
    <name>A0A2M9JLP0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_32575</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000018">
        <property type="protein sequence ID" value="PJN07801.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN07801">
        <property type="protein sequence ID" value="PJN07801"/>
        <property type="gene ID" value="CG723_32575"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="17"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="45"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="79"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="172"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="213"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="247"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="278"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="304"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="335"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="364"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="395"/>
            <end position="419"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN07801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="419" mass="42467" checksum="571C11C79EAFA637" modified="2018-04-25" version="1">MAAGYAEILKARHATRLLVGTLVGRLPNATAAIAIVLFVRAEGGTYSLAGALAAVYGVANAVGQPLLGRLVDLRGQPRVQLPAALASALAMTVFAFAGTGSPALAYVAVAAAGLFTPPLEGGLRALWPNVLPREDQVHTAYAMDAVAQEVMFTVGPLLVTVCVSLWSAQAALVVLNVVGVLGALSVVVSQPSRAWRSAPREAHWLGALRSPGLLALLGAFLFIGTALGSITVAGVSYADGHGGDVTYGWLMAALGLGALAGGSVYGARQWAGVPERRLRWLVALLALFYVPLVLMPGVVAMTALTALAGVFLAPSIACAFIIVDRHAPRGTVTEAFSWLVTTFTVGTSVGTAVAGPVVEWGGTVWGFAVPGAAGVAALLVLLATGGVLAAPRGAGRVAGSSENDRNGAVEPGFSTGHQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JLR5</accession>
    <name>A0A2M9JLR5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Precorrin-6y C5,15-methyltransferase (Decarboxylating) subunit CbiE</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">cbiE</name>
        <name evidence="8" type="ORF">CG723_32110</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CB01635</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; adenosylcobalamin biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the precorrin methyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000018">
        <property type="protein sequence ID" value="PJN07717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN07717">
        <property type="protein sequence ID" value="PJN07717"/>
        <property type="gene ID" value="CG723_32110"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00148"/>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008276">
        <property type="term" value="F:protein methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009236">
        <property type="term" value="P:cobalamin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd11644">
        <property type="entry name" value="Precorrin-6Y-MT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.950.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1010.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000878">
        <property type="entry name" value="4pyrrol_Mease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035996">
        <property type="entry name" value="4pyrrol_Methylase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014777">
        <property type="entry name" value="4pyrrole_Mease_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014776">
        <property type="entry name" value="4pyrrole_Mease_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012818">
        <property type="entry name" value="CbiE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006365">
        <property type="entry name" value="Cbl_synth_CobL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00590">
        <property type="entry name" value="TP_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036428">
        <property type="entry name" value="CobL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53790">
        <property type="entry name" value="SSF53790"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02467">
        <property type="entry name" value="CbiE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="TP_methylase" evidence="6">
        <location>
            <begin position="15"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="domain" description="Methyltransf_11" evidence="7">
        <location>
            <begin position="260"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PJN07717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="403" mass="42130" checksum="E6A0B18747D083DD" modified="2018-04-25" version="1">MADRVTVIGWDGSPLTAAARSALGAATLVAGAGHHLALPEVPGRAERIRLGSVSLAARRIAAHRGTAVVLADGDPGFFGVVRTLRAREFGLEVEVVPAVSSVAQAFARAGMPWDDAQVVVAHRRTLRRAVNVCRAHPKVAVLTSPGAGPAELGLLLEGVHRTFVICEELGTDREQVTVVTSDKAADHTWRDPNVVIVIGGTTAPSDESAWLAGGAPSAGVRGWALPAAEYGGGLGEGETEPLRAAQLARTGPRVGDLVWDIGCGSGAFTAEAARFGAAVIAVDRDPDACARTLATARRFGVQPQIVHGTAPHILEDLPEPDVVRIGGGGAAVVSAVADRRPERIVTHAATRDAAELIGRDLTEHGYRVECSLLQSVELDTRAWTEKERTVGFLLSGELPDRNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JM96</accession>
    <name>A0A2M9JM96_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Phytanoyl-CoA dioxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_30335</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000016">
        <property type="protein sequence ID" value="PJN07996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN07996">
        <property type="protein sequence ID" value="PJN07996"/>
        <property type="gene ID" value="CG723_30335"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008775">
        <property type="entry name" value="Phytyl_CoA_dOase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05721">
        <property type="entry name" value="PhyH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="250"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN07996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="280" mass="31721" checksum="CD02020715BAE3C4" modified="2018-04-25" version="1">MTVKTVTTTSAMPELDRPYDRLASTAVADFNRDGFVHLRNVLTPETIAAYEPTITSEVIRLNTQNLPLAERDTYGKAFLQVTNLWEHSEKVQELVFSRRLARIAAEVLGVHAVRLYHDQALYKEPSGGITPWHADQYYWPLSSDRCLTVWLPLQETPMEMGPIAFARGSHHFAYGRDLPISDESEARLKETVTEQNFEDVAEPFALGDASFHRGWTFHHAGPNRANVPRRVMTVIYIDADIRVAEPTNDHQAADRGWMPGTRIGQVPDTPLNPVLYDARR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JMF7</accession>
    <name>A0A2M9JMF7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">AsnC family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CG723_30715</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000016">
        <property type="protein sequence ID" value="PJN08056.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08056">
        <property type="protein sequence ID" value="PJN08056"/>
        <property type="gene ID" value="CG723_30715"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000485">
        <property type="entry name" value="AsnC-type_HTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019888">
        <property type="entry name" value="Tscrpt_reg_AsnC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019887">
        <property type="entry name" value="Tscrpt_reg_AsnC/Lrp_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01037">
        <property type="entry name" value="AsnC_trans_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00033">
        <property type="entry name" value="HTHASNC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00344">
        <property type="entry name" value="HTH_ASNC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50956">
        <property type="entry name" value="HTH_ASNC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH asnC-type" evidence="4">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PJN08056.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="150" mass="16909" checksum="84712646B5CA144F" modified="2018-04-25" version="1">MDAMDRKILTELQLDGRLTITELAARVQLSVSPCHRRLRDLEREGAIRGYRAVVDPAAVGLDFEALVFATLRWEHRDTVTAFEEAVSAIPHVIQAQRLFGDPDYLLRVATADLAAYQQLYDQQLAQLPGVQRLTSTLVMKNVVQDRPLPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JMG0</accession>
    <name>A0A2M9JMG0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Sarcosine oxidase subunit delta</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CG723_30745</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000016">
        <property type="protein sequence ID" value="PJN08061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08061">
        <property type="protein sequence ID" value="PJN08061"/>
        <property type="gene ID" value="CG723_30745"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008115">
        <property type="term" value="F:sarcosine oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046653">
        <property type="term" value="P:tetrahydrofolate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2270.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006279">
        <property type="entry name" value="SoxD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038561">
        <property type="entry name" value="SoxD_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04267">
        <property type="entry name" value="SoxD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01374">
        <property type="entry name" value="soxD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PJN08061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="101" mass="11859" checksum="3BF40B6ADDBBD208" modified="2018-04-25" version="1">MLLINCPWCGPHNESEYHYGGQAHVPYPENPADLDDGQWAEYVFYRDNPKGPFAERWMHSHGCRRWFNALRDTVSYEVLATYRLDEPRPEPHVTDPAGEQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JMN9</accession>
    <name>A0A2M9JMN9_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Exodeoxyribonuclease 7 large subunit</fullName>
            <ecNumber evidence="5">3.1.11.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Exodeoxyribonuclease VII large subunit</fullName>
            <shortName evidence="5">Exonuclease VII large subunit</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">xseA</name>
        <name evidence="9" type="ORF">CG723_29405</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CB01635</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5 6">
            <text>Exonucleolytic cleavage in either 5'- to 3'- or 3'- to 5'-direction to yield nucleoside 5'-phosphates.</text>
            <dbReference type="EC" id="3.1.11.6"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="5">Heterooligomer composed of large and small subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5 6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 6">Belongs to the XseA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.11.6" evidence="5"/>
    <dbReference type="EMBL" id="NNBL01000015">
        <property type="protein sequence ID" value="PJN08126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08126">
        <property type="protein sequence ID" value="PJN08126"/>
        <property type="gene ID" value="CG723_29405"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009318">
        <property type="term" value="C:exodeoxyribonuclease VII complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008855">
        <property type="term" value="F:exodeoxyribonuclease VII activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006308">
        <property type="term" value="P:DNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04489">
        <property type="entry name" value="ExoVII_LU_OBF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00378">
        <property type="entry name" value="Exonuc_7_L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003753">
        <property type="entry name" value="Exonuc_VII_L"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020579">
        <property type="entry name" value="Exonuc_VII_lsu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025824">
        <property type="entry name" value="OB-fold_nuc-bd_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30008">
        <property type="entry name" value="PTHR30008"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02601">
        <property type="entry name" value="Exonuc_VII_L"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13742">
        <property type="entry name" value="tRNA_anti_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00237">
        <property type="entry name" value="xseA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 5 6" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="3 5 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 5 6" id="KW-0540">Nuclease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="tRNA_anti_2" evidence="8">
        <location>
            <begin position="12"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="domain" description="Exonuc_VII_L" evidence="7">
        <location>
            <begin position="129"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="domain" description="Exonuc_VII_L" evidence="7">
        <location>
            <begin position="332"/>
            <end position="398"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU004355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF13742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PJN08126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="408" mass="44498" checksum="DD159C0DD319D486" modified="2018-04-25" version="1">MAVNTSADAPLPVGEVSRLIGRWIDRLGAVWVEGQITQLSRRPGAGVVFLTLRDPSHDISVGVTCYRQVFDAVADVVTEGARVVVQAKPEWYAPRGQLSLRASEIRPVGVGELLARLEQLKKSLAGEGLFAPERKKPLPFLPQLIGLVCGRASAAERDVLENARHRWPAVRFEVRNVPVQGVHAVPQVVQAVKELDSLDDVDVIIVARGGGSVEDLLPFSDEQLVRAVAACRTPVVSAIGHEPDNPLLDHVADLRASTPTDAAKKVVPDVGEEYERVQWLRDRARRSVESFVDREERGLGQALARPVMEDPHRMIEVREEQVTALAERGRRTLGHLLDRAASELSHTHARVVALSPAATLKRGYAVLQKADGDVVRAADDVAADEVLRARVAEGEFTVRVETGNQESA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JMS3</accession>
    <name>A0A2M9JMS3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CG723_30625</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CB01635</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">In the C-terminal section; belongs to the transposase 35 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000016">
        <property type="protein sequence ID" value="PJN08107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08107">
        <property type="protein sequence ID" value="PJN08107"/>
        <property type="gene ID" value="CG723_30625"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032196">
        <property type="term" value="P:transposition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001959">
        <property type="entry name" value="Transposase_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010095">
        <property type="entry name" value="Transposase_IS605_OrfB_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01385">
        <property type="entry name" value="OrfB_IS605"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07282">
        <property type="entry name" value="OrfB_Zn_ribbon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0815">Transposition</keyword>
    <feature type="domain" description="OrfB_IS605" evidence="5">
        <location>
            <begin position="5"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="domain" description="OrfB_Zn_ribbon" evidence="6">
        <location>
            <begin position="137"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF07282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PJN08107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="241" mass="27026" checksum="5BECF7465854A279" modified="2018-04-25" version="1">MGPGVGIDVGISRPMALSDGTFRDHHTWLRPKEAERLRRLERTRERQKQHRKPGEKTSNRLRRTNRLIAGYHARAKRRTLDWQHKTTTGIADMFGVVGVEALKITNMVKSARGTAEEPGKNVRQKAELNRSISAEAWGRTVTLLEYKLSDRGGHLIKVPAPNTSRRCHACGFITEGNRETQAVFVCKNETCGWSGNADTNGSFNIEIATKYQTPQEIVGVRTWSLSQWAGREASTTHPVAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JMT1</accession>
    <name>A0A2M9JMT1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">ABC transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CG723_29630</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000015">
        <property type="protein sequence ID" value="PJN08169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08169">
        <property type="protein sequence ID" value="PJN08169"/>
        <property type="gene ID" value="CG723_29630"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042597">
        <property type="term" value="C:periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030678">
        <property type="entry name" value="Peptide/Ni-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039424">
        <property type="entry name" value="SBP_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000914">
        <property type="entry name" value="SBP_5_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30290">
        <property type="entry name" value="PTHR30290"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00496">
        <property type="entry name" value="SBP_bac_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002741">
        <property type="entry name" value="MppA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014993648" evidence="2">
        <location>
            <begin position="35"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="domain" description="SBP_bac_5" evidence="3">
        <location>
            <begin position="119"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="24"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PJN08169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="596" mass="64966" checksum="EF8EFC78B0C44822" modified="2018-04-25" version="1">MKSLNARTTRAIVIAIAAGSLALTGCSSDSKGKAKDDSKNQKDASSQSKPVAYGDAAASNGPAEAIPGAKNGGKITVYAQSDLTHMDPGQTYVSDAGQFGNLITRGLTNFQEDAKGNLTVVGDVATDSGKSSDGGKTWTYTLKDGIKDDQGNVITSKDVRHTIERQYAKFIFDGPTYVQTWLSGQDYRKKLPDGPFKGKHLPDSVLSTPDDKTVVFHFDTARPDLPQALAMAGYGIVPEKRDTKEKYDKAPASLGPYKLADYKAGKSLTLVKNTNWDPKTDSVRHQYVDGYNFELTVAQDSQTKRLIADQGEAKTAIQFTDIVDPAQLQDVVTDPKVNKRTIKGYQPYVWQMTYNLDRMKDKKVRDAITYAIPSQRMVQADGGKYGGEIAGGLFAPTLPNFDPKFDPFGKLKKPNGDLPMAQKLIKEAGVKKGTKLTYAYSNTPRGQAQMVIIKDTLTKLGFDVQAKEIDRASFYEQVGKLKNPYDLYMTGWGQDWPSEGTVVTPVYDGSTVQDGGSNYSHIADPQVDAGIKEALKLDPAAAKAKWAELHKRIVEEIDPAAPVYYSKSIQLFGSGIGGAKYSTESSYVDINDLFVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JMT6</accession>
    <name>A0A2M9JMT6_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">1D-myo-inositol 2-acetamido-2-deoxy-alpha-D-glucopyranoside deacetylase</fullName>
            <shortName evidence="3">GlcNAc-Ins deacetylase</shortName>
            <ecNumber evidence="3">3.5.1.103</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">N-acetyl-1-D-myo-inositol-2-amino-2-deoxy-alpha-D-glucopyranoside deacetylase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3 4" type="primary">mshB</name>
        <name evidence="4" type="ORF">CG723_29690</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CB01635</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the deacetylation of 1D-myo-inositol 2-acetamido-2-deoxy-alpha-D-glucopyranoside (GlcNAc-Ins) in the mycothiol biosynthesis pathway.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>1D-myo-inositol 2-acetamido-2-deoxy-alpha-D-glucopyranoside + H2O = 1D-myo-inositol 2-amino-2-deoxy-alpha-D-glucopyranoside + acetate</text>
            <dbReference type="Rhea" id="RHEA:26180"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="ChEBI" id="CHEBI:52442"/>
            <dbReference type="ChEBI" id="CHEBI:58886"/>
            <dbReference type="EC" id="3.5.1.103"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="3">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the MshB deacetylase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.103" evidence="3"/>
    <dbReference type="EMBL" id="NNBL01000015">
        <property type="protein sequence ID" value="PJN08180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08180">
        <property type="protein sequence ID" value="PJN08180"/>
        <property type="gene ID" value="CG723_29690"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035595">
        <property type="term" value="F:N-acetylglucosaminylinositol deacetylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010125">
        <property type="term" value="P:mycothiol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10320">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01696">
        <property type="entry name" value="MshB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003737">
        <property type="entry name" value="GlcNAc_PI_deacetylase-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024078">
        <property type="entry name" value="LmbE-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017810">
        <property type="entry name" value="Mycothiol_biosynthesis_MshB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12993">
        <property type="entry name" value="PTHR12993"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02585">
        <property type="entry name" value="PIG-L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102588">
        <property type="entry name" value="SSF102588"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03445">
        <property type="entry name" value="mycothiol_MshB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0862">Zinc</keyword>
    <feature type="binding site" evidence="3">
        <location>
            <position position="15"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="18"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="150"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PJN08180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="297" mass="31918" checksum="BB669170740CD469" modified="2018-04-25" version="1">MTELPDRRLLLVHAHPDDESINNGATMAKYAADGAHVTLVTCTLGEEGEVIPDVLAHLAPDREDILGPHRIGELTAAMKELGVTDHRFLGGPGRFRDSGMTGAEQNDRPGAFWAADLDEAAAHLVEVIREVRPQVLVTYDPDGGYGHPDHIKAHRVAMRAAELAAEPAFRRDLGDTHAVSKIYWNRVPRSVVEERFRWLAGVLGSTPYGTAAEIGDVPGVVDDERVTAEIDGRAFAAAKTAAMRAHATQVEIAPGGEPVFALSNGLAQPVFDVEYYELARGEAAAPHETDLFAGVVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-09-29" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JMY4</accession>
    <name>A0A2M9JMY4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Glutaredoxin-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CG723_30015</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000015">
        <property type="protein sequence ID" value="PJN08238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08238">
        <property type="protein sequence ID" value="PJN08238"/>
        <property type="gene ID" value="CG723_30015"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097573">
        <property type="term" value="F:glutathione oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011915">
        <property type="entry name" value="GlrX_actino"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002109">
        <property type="entry name" value="Glutaredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017937">
        <property type="entry name" value="Thioredoxin_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00462">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02200">
        <property type="entry name" value="GlrX_actino"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00194">
        <property type="entry name" value="THIOREDOXIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutaredoxin" evidence="3">
        <location>
            <begin position="5"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PJN08238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="87" mass="9262" checksum="7295E1847325C1DA" modified="2018-04-25" version="1">MPGTVTMYSTTWCGYCRRLKGQMDREGIEYNEVNIEQDPDSAAFVEKANGGNQTVPTVQVVPANGGVEVIMTNPSLAQVKQALGGAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JMZ2</accession>
    <name>A0A2M9JMZ2_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">NAD(+) diphosphatase</fullName>
            <ecNumber evidence="2">3.6.1.22</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CG723_30005</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CB01635</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.22" evidence="2"/>
    <dbReference type="EMBL" id="NNBL01000015">
        <property type="protein sequence ID" value="PJN08236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08236">
        <property type="protein sequence ID" value="PJN08236"/>
        <property type="gene ID" value="CG723_30005"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000210">
        <property type="term" value="F:NAD+ diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015375">
        <property type="entry name" value="NADH_PPase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015376">
        <property type="entry name" value="Znr_NADH_PPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09296">
        <property type="entry name" value="NUDIX-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09297">
        <property type="entry name" value="zf-NADH-PPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="SSF55811"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0520">NAD</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="7">
        <location>
            <begin position="171"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PJN08236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="316" mass="34805" checksum="888CA0D0C7EDDB2D" modified="2018-04-25" version="1">MTTWTDRTADRPLSLSAPSGIDRAAHHRLDEAWLAAAWSHPTTRVFVVSGGQVLIDETPDGATELVMTPSFEAPLTEAHRYFLGTDDDGVSYFALQKDTLPGRIDQSARAAGLREAGLLLSPRDAGLMVHAVALENWQRLHRFCSRCGERTVIAAAGHIRRCQACGAEHYPRTDPAVIMLVTDDEDRALLGRQVHWPEGRFSTLAGFVEPGESIEQSVRREVFEEAGVVVGPDVEYVASQPWPFPSSLMLGFMARATSSEINVDGEEIHEARWFSREDLRAAFESGEVMPPYGISIAARLIELWYGKPLPKPGDAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JN40</accession>
    <name>A0A2M9JN40_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">LysR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_28195</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000014">
        <property type="protein sequence ID" value="PJN08286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08286">
        <property type="protein sequence ID" value="PJN08286"/>
        <property type="gene ID" value="CG723_28195"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02199">
        <property type="entry name" value="YjgF_YER057c_UK114_like_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013813">
        <property type="entry name" value="Endoribo_LPSP/chorism_mut-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035959">
        <property type="entry name" value="RutC-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14588">
        <property type="entry name" value="YjgF_endoribonc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55298">
        <property type="entry name" value="SSF55298"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YjgF_endoribonc" evidence="1">
        <location>
            <begin position="7"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN08286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="156" mass="15815" checksum="F0FDE6C5BD948384" modified="2018-04-25" version="1">MSGVVDARLAELGLTLPEVVPPLASYQPAVQSGVYVYTAGQLPMVDGKLPVTGKVGAEVTAEQAKELARTCALNALAAVKSVAGDLDRVARVVKVVGFVASAPDFTGQPGVVNGASELFAEVLGEKGVHARSAVGVAVLPLDAPVEVEVQVELVSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JNE2</accession>
    <name>A0A2M9JNE2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_28775</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000014">
        <property type="protein sequence ID" value="PJN08380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08380">
        <property type="protein sequence ID" value="PJN08380"/>
        <property type="gene ID" value="CG723_28775"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014987165" evidence="1">
        <location>
            <begin position="22"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN08380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="68" mass="7062" checksum="80885D8F00276CF6" modified="2018-04-25" version="1">MEVRTKPTMCKKMLRSVMAVAFSAGLAFGVLSTQDLSWSGTPATHASAGKNIAPPDLSWSVAPVDAAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JNW6</accession>
    <name>A0A2M9JNW6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Peptide synthetase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_27540</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000013">
        <property type="protein sequence ID" value="PJN08535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08535">
        <property type="protein sequence ID" value="PJN08535"/>
        <property type="gene ID" value="CG723_27540"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008610">
        <property type="term" value="P:lipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001242">
        <property type="entry name" value="Condensatn"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00668">
        <property type="entry name" value="Condensation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Condensation" evidence="1">
        <location>
            <begin position="68"/>
            <end position="456"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN08535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="462" mass="50385" checksum="71DBAF1C13864CAA" modified="2018-04-25" version="1">MAVTLKDDFAERARLEARLLARRRGGAALPLLDRPSGAEWHFAASLGQEGMWPSLATTARQPLIVGGLRVSGPLDTGALREAWQALAERHETLRSAYRTVDGTLTQVVPVRARPVMEVALADPAAAASVADDELARPFDFGRGPVARLRVLRRASGEHLVVVCLHHLVGDARALEVVTTELTALYAGAVTGSPVELPELPAQYADFAAWHRARVEGEHGGRTIAYWLDRLAGAEPAALPCDGSQDPSDVAGRTRSFPLPPELFARLREVAARHRTTFYVVGLAAFQILLARWSGERDICVRAPVSYRDRSDVHGLVGDFSNDVVVRADLSGHVTLAEAVEQVRASTADDFAHHDVPPHVVASRMADPTLLERLFHVQFTAEREHDLGAARQLGPLRAEPFSPTAETVARPLSVRLRHDDHGGRVIVAHRSGLFSDERVRALQRDYFALFEEIAAYPGRPAVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-09-29" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JP11</accession>
    <name>A0A2M9JP11_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CG723_27980</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CB01635</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000013">
        <property type="protein sequence ID" value="PJN08600.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08600">
        <property type="protein sequence ID" value="PJN08600"/>
        <property type="gene ID" value="CG723_27980"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="51"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="84"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="108"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="142"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="177"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="261"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="302"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="326"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="352"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="390"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="422"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="7">
        <location>
            <begin position="18"/>
            <end position="445"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PJN08600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="472" mass="49949" checksum="9690E62CA460AB51" modified="2018-04-25" version="1">MESTTRPSAGHMRSVIVITCVTAVGGFLFGFDNGAISGTAGFIQDRFGLSAGGLGWVTSSIIVGCIIGVVIAGRLSDAIGRKKVMLGTAVVFLVGALGEGLAPNAELLVAARILVGIGIGTETTIAPLYIAEVAPAHLRGRLVSFNQLFNTVGNLVVFSVSALIARASSDSWNTEHGWRYIFVIGIVPAVVFFGLLFLVPESPRWLIRQGRTGEGLAALRRISPTRSDAEAELAAIEASMAIEGSRAGISDVLAPRFRKTLVIGFGVALFQQITGINAIFYYAPEVFKSAGLQANDAMSSTVLIGVTLVAATLVSMWLIDRVGRRTLLLTGASAMTVLLASIGLVFRSTHPSAPLLLALILGYVAFFAVSFGTITYVIISEIFPTHIRGVAASIATFALWGGNYLVSQFFPMLVEGIGSSSTFFIFSGISLLALLFTVALVPETKNRSLEEIERELYGNRHPVDMGRAATTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-09-29" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JP44</accession>
    <name>A0A2M9JP44_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">FAD-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CG723_27740</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CB01635</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the oxygen-dependent FAD-linked oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000013">
        <property type="protein sequence ID" value="PJN08567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08567">
        <property type="protein sequence ID" value="PJN08567"/>
        <property type="gene ID" value="CG723_27740"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.43.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012951">
        <property type="entry name" value="BBE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016167">
        <property type="entry name" value="FAD-bd_PCMH_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019546">
        <property type="entry name" value="TAT_signal_bac_arc"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08031">
        <property type="entry name" value="BBE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10518">
        <property type="entry name" value="TAT_signal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="SSF56176"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01409">
        <property type="entry name" value="TAT_signal_seq"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014942138" evidence="2">
        <location>
            <begin position="30"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="3">
        <location>
            <begin position="78"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PJN08567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="502" mass="54326" checksum="9C7FEA43223265E5" modified="2018-04-25" version="1">MSDFSRRRLLKTSAVAGAGAVVVPGVAQAATPSASVVMEASVHEAHEAQCSPAKLTGRIVRPHDPGYTDARLGWDQLFSHYPLVIVFAQNTQDVVNALTWARQNDVALRIRSGRHSLEGWSNVDSGLVIDISELKSVHLDSAARVATVGAGLNQLEAVTTLAKRNFAVTTGTEGTVGLAGATLGGGFGFLTRWLGMACDSLIGAEVVVAEGGECAKVIKADLTHNSDLLWALRGAGNGNFGIVTSLTYKVAPLKSVTYVQATWDGIGDLRRVFNAWQRTALHADDRLGTQVEIHRNQTLLFAVLAEGTPAEAKKLLAPILSVGSPQVSVQVGNWGEVYSGFQIPTANEPANWKFYSQFTRKPFPGKAIDVICSFMKHAPTDDSNFFTQAFGGAVRRSPRGGTAFPHRDALFYSEPGAGWGTRSDQPGICDPLTPQAQAWIAEFSQALRPYVDGAYVNVPNVGMQDWETAYWRDNFDRLREIKAKYDPHNVFQYDQSIPPASR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JPA1</accession>
    <name>A0A2M9JPA1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_26770</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000012">
        <property type="protein sequence ID" value="PJN08701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08701">
        <property type="protein sequence ID" value="PJN08701"/>
        <property type="gene ID" value="CG723_26770"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004721">
        <property type="term" value="F:phosphoprotein phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016311">
        <property type="term" value="P:dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026893">
        <property type="entry name" value="Tyr/Ser_Pase_IphP-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13350">
        <property type="entry name" value="Y_phosphatase3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="SSF52799"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014844884" evidence="1">
        <location>
            <begin position="30"/>
            <end position="360"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN08701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="360" mass="38576" checksum="5299A96EE6AC3565" modified="2018-04-25" version="1">MTQMTRVRASSYALAAALLVGLSAPVAAAHPASHDGQTSHHRIPFTAATVTASEDGSSFTVEWKAPGLRHVVVRAGGRTVASGGSTGKVTVRGLPAADRQWFDLVPDRGQGLHLADREIRLDGAVNFRDAGGYRTTDGHWVRMGEIYRTASLDKLTDRDLAKLKRLGISVDYDLRTQQERASAPDRVPAGSRYVVADVLGDLGGLSGMPATPEAAAQLMVDAERTMVSAPTAQKAYTTVFQGIADADGANALFHCTAGKDRTGWANATLLTALGVPRETVMNDYLASNTYRAKENAATLAAMPPAQAAVYKPMLDVRPEYLNSGFQEVTSRYGTFDHYLDNALGLSHHDVRDLREDLLVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JPH0</accession>
    <name>A0A2M9JPH0_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RcpC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_27005</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000012">
        <property type="protein sequence ID" value="PJN08735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08735">
        <property type="protein sequence ID" value="PJN08735"/>
        <property type="gene ID" value="CG723_27005"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031571">
        <property type="entry name" value="RcpC_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16976">
        <property type="entry name" value="RcpC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RcpC" evidence="2">
        <location>
            <begin position="92"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="55"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="58"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF16976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN08735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="194" mass="18604" checksum="3F59B9B18A0C53F0" modified="2018-04-25" version="1">MSPFSTPPTCEVPHFAPLRVRGGRWRARRAGRHRRRAVAAGLAVTAAVLVAAGPSGAGSSGAGSSGAGASGAGSGSSESASGRERVRRSVVMVSAPVRIADAAAVRLLRPGDRVDVVAAGAGAGVGAGDGQGSGGQGGRVVAAGARVSSVPESPESAGDAVAEGGALVVLSVPRATAARLAGAGAASRLAVTLW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JQK7</accession>
    <name>A0A2M9JQK7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Aminoacyl-tRNA hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CG723_24900</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CB01635</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the prokaryotic/mitochondrial release factor family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000010">
        <property type="protein sequence ID" value="PJN09153.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN09153">
        <property type="protein sequence ID" value="PJN09153"/>
        <property type="gene ID" value="CG723_24900"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003747">
        <property type="term" value="F:translation release factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000352">
        <property type="entry name" value="Pep_chain_release_fac_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045853">
        <property type="entry name" value="Pep_chain_release_fac_I_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00472">
        <property type="entry name" value="RF-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75620">
        <property type="entry name" value="SSF75620"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RF_PROK_I" evidence="3">
        <location>
            <begin position="14"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="102"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PJN09153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="145" mass="16396" checksum="700205A1554CB8E2" modified="2018-04-25" version="1">MEPMSGPYFIRGSVVLPEAELLWRFSRSSGPGGQHVNTSDSQVELRFDLARTEALPEVWKARALERLASRLVDGVISVRSSEHRSQWRNRETAAVRLASLLAEATAPPPKPRRATRIPRGINERRLRNKKARSDTKRGRSGRGWD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JQK8</accession>
    <name>A0A2M9JQK8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_24435</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000010">
        <property type="protein sequence ID" value="PJN09077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN09077">
        <property type="protein sequence ID" value="PJN09077"/>
        <property type="gene ID" value="CG723_24435"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="58"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="94"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="94"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN09077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="297" mass="31287" checksum="AB3575739ED3F939" modified="2018-04-25" version="1">MSDADTTPGAAPADGAISPGAVPADGAISPGAVPADGTTLPEAVTPGTRPPGDRRRRLLTRVAVPVLLLGVVAGGVGYTVVRVEGADRDAGAARYKFPDTPRDRPARDKGRTGLKASLLPMPEGYRAGPDIAGFGADTELSGRQAAALRKQSLRPLPLKERRRLEGEFDRQEIKGMAMRSYASGNRADGGIVVTISLSRMGNRQAARQISRFQSRFAEAMTVFRKGPKIKGHKDAGCFLPPADKEEKLDIMVCSGYSGDVLVSFTAYGTKDGLVSSGEPAELMREQLDAVESPGEAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JQN0</accession>
    <name>A0A2M9JQN0_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">YceI domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_25030</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000010">
        <property type="protein sequence ID" value="PJN09176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN09176">
        <property type="protein sequence ID" value="PJN09176"/>
        <property type="gene ID" value="CG723_25030"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.128.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007372">
        <property type="entry name" value="Lipid/polyisoprenoid-bd_YceI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036761">
        <property type="entry name" value="TTHA0802/YceI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04264">
        <property type="entry name" value="YceI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00867">
        <property type="entry name" value="YceI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101874">
        <property type="entry name" value="SSF101874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YceI" evidence="1">
        <location>
            <begin position="9"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN09176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="176" mass="18598" checksum="6AC4FAF0F6B2C9A8" modified="2018-04-25" version="1">MTVAVETGQWQLDADASTVALKHRTMWGLVTVKGAFGVVGGGGEVRPDGTVTGAVTLDAASLDTKNAKRDTHLRSADFFDVEKHPEITFEVRGVETGADAAAQVDGQLTVRGVSRPVSVPVRLTREGTDAVTLAAEFTVDRAEFDMGWNQLGMLRGLTAVAGSLRFTRVPGGVQES</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JQR9</accession>
    <name>A0A2M9JQR9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CG723_24810</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000010">
        <property type="protein sequence ID" value="PJN09137.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN09137">
        <property type="protein sequence ID" value="PJN09137"/>
        <property type="gene ID" value="CG723_24810"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PJN09137.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="131" mass="14621" checksum="7AA82356C7DE48F1" modified="2018-04-25" version="1">MGTAYARCYDPSGARYGIPTYPWKFAPEGLATRRQLRAQGLRPGGQPIAAQLMRTSRRRKTGAAVAYLYRVDRARPVRPMTSRKWGALAMAMLARRTCPVCRITYSYCLPTSLGMCVTCAYSDPSDFQRSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JR04</accession>
    <name>A0A2M9JR04_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Acyl-CoA dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CG723_23315</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CB01635</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000009">
        <property type="protein sequence ID" value="PJN09284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN09284">
        <property type="protein sequence ID" value="PJN09284"/>
        <property type="gene ID" value="CG723_23315"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016627">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="SSF47203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="SSF56645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0274">FAD</keyword>
    <keyword evidence="3 5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA_dh_N" evidence="8">
        <location>
            <begin position="8"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_M" evidence="7">
        <location>
            <begin position="133"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_1" evidence="6">
        <location>
            <begin position="245"/>
            <end position="395"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PJN09284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="417" mass="46006" checksum="3AFF1C0CAF40A0A8" modified="2018-04-25" version="1">MDFGFSPRASELQDRMRSFMEQHVFPAEPVYDRQLAEADDPHALPPVMTELKEKARAEGLWNLFMAHGDWGAGLTNLEYAPLMGLAGRSIIGPEVFNCSAPDTGNMELLALYGTPEQQQRWLRPLLEAEIRSCFAMTEPEVASSDARNIRTRITRDGDSYVVNGRKWYTSGILDPDCKLIVLMGKTDPDAPTYRQQSMLLIPRDTPGVTVVRDLPMFGYTDRCGHGEVLFENVRVPVGNILGGEGEGFALAQGRLGPGRMHYAMRAVGFAERALQLMCERATERVAFGGPLAERGVVREWIARSRIEIEQLRLLVLKSAWLMDTVGNAAARMEVAAIKVAALEVAHKVVDRAVQTHGAAGVSDDTVLARLFSITRALKIADGPDEVHLRTVARQELAKYQTKNEKTDTKTDAKAGAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JR06</accession>
    <name>A0A2M9JR06_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ribose-5-phosphate isomerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_23480</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LacAB/RpiB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000009">
        <property type="protein sequence ID" value="PJN09311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN09311">
        <property type="protein sequence ID" value="PJN09311"/>
        <property type="gene ID" value="CG723_23480"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016861">
        <property type="term" value="F:intramolecular oxidoreductase activity, interconverting aldoses and ketoses"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1400.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003500">
        <property type="entry name" value="RpiB_LacA_LacB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036569">
        <property type="entry name" value="RpiB_LacA_LacB_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02502">
        <property type="entry name" value="LacAB_rpiB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005384">
        <property type="entry name" value="RpiB_LacA_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89623">
        <property type="entry name" value="SSF89623"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00689">
        <property type="entry name" value="rpiB_lacA_lacB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Proton acceptor" evidence="2">
        <location>
            <position position="65"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="2">
        <location>
            <position position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR005384-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN09311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="151" mass="15880" checksum="936E0FB285C02FC2" modified="2018-04-25" version="1">MQVALGADHAGYALKAAVHEAIEALGHEVIDCGTHSCDPVDFPDITRTTCEVVLSGSADRAVLVCGTGQGAVMAANKLPGIRCGLAHEPYSAHQAVEHDDANTIAMGAWLVPHALVPDIIREFLGAVFDDDEDTRRRVSKLNALDALTSAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-06-02" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JR34</accession>
    <name>A0A2M9JR34_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Taurine dioxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CG723_23645</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000009">
        <property type="protein sequence ID" value="PJN09335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN09335">
        <property type="protein sequence ID" value="PJN09335"/>
        <property type="gene ID" value="CG723_23645"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042098">
        <property type="entry name" value="TauD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003819">
        <property type="entry name" value="TauD/TfdA-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02668">
        <property type="entry name" value="TauD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TauD" evidence="4">
        <location>
            <begin position="16"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PJN09335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="326" mass="36227" checksum="063949E3A6D9E39F" modified="2018-04-25" version="1">MTSTISSKPTTSTATARPASGHTGADISGVDLSKPLSDGDLAVIKEALHRWKVVFFRGQDLDHASQIAFARQFGDLTYAHPHDDTPPEDHPEIFTIDPRRYEERYGKGFREATKKRRYSYFSGWHTDVTASVNPPAGSILRAETVPEFGGDTQWTNLVAAYEGLSAPVRAFVDTLRAEHRYGGAEKPTGDSAYARRVNDNLLVAVHPVVRVHPETGERALFVNPGFTSHIVDVTPSESRTILNLLYEEITRPEYTVRFRWEPGSVAFWDNRATAHLAPRDIEHLNVERRLHRVTLIGELPVGPDGQESELVAGKPFTADHRVVVGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JRD3</accession>
    <name>A0A2M9JRD3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_24085</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000009">
        <property type="protein sequence ID" value="PJN09404.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN09404">
        <property type="protein sequence ID" value="PJN09404"/>
        <property type="gene ID" value="CG723_24085"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="434"/>
            <end position="454"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN09404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="708" mass="78511" checksum="CA8C3173529DC3C2" modified="2018-04-25" version="1">MTPDQVYALLPAVHRRLDAEHGSKLYELLSVIAAQARVVQDDIEQLYDNWFIETCEDWVVPYIGDLVRYRILPGTTAALSDNSSPAYGLLAAAAPRREVANTVANRRRKGTLALLEDLAADVADWPSRAVECRRLLAVTQPIRRYTTEDYDARRRLRRGGLVDLRRIDTLDRIDGPFDELAHTVEVPRADSSRRVGQYNIPGVGLHVWRLRAHPVTMAPALCVDRARSCYTFSILGNDTELFTKPVPEPSACHVADEMNVPAPIRRRALTERLYDYYGPLKSVCVWTGPHPDLDVAALDRIVSADLSDWSYSPRAGQVALDPVLGRIRFPEQTDLERGVRVTYHHAFPSDFGGGEYPRPGNTVGPTVVRYRVGPREEHHRITDAIERWRSERPHSPEAIIEITGNDVHRDLKNILLEPEDRLTLRAEDGSRPVLALPDRTENGPASLRITGTGPREGNLPRIVLDGLMVTGGSVQVRGKVGQLIVRHCTFVPGWDLGAHGLPRSPEEASLELIGTPVCVEIEHSILGTVVVSRDEAAAEPNRIFLTDSVLDATHPELAALTGPDGRYAHALLTARRTTVIGSVRTRAVDMVENCLLDGDVQIAQQTKGSVRFCWLPPGSRTPRRLYCQPEHSGDPDRVALKFAGTRYGTPDYVRLTDACAEEIRRGADDGSEPGALHDLFRPQRQDNLRARLAEYTPAGCNAGVFFAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JRF8</accession>
    <name>A0A2M9JRF8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">GntR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CG723_24010</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000009">
        <property type="protein sequence ID" value="PJN09434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN09434">
        <property type="protein sequence ID" value="PJN09434"/>
        <property type="gene ID" value="CG723_24010"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07377">
        <property type="entry name" value="WHTH_GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.530">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011711">
        <property type="entry name" value="GntR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008920">
        <property type="entry name" value="TF_FadR/GntR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07729">
        <property type="entry name" value="FCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
        <property type="entry name" value="GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00035">
        <property type="entry name" value="HTHGNTR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00895">
        <property type="entry name" value="FCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00345">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48008">
        <property type="entry name" value="SSF48008"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50949">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH gntR-type" evidence="5">
        <location>
            <begin position="25"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PJN09434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="267" mass="29398" checksum="361B513522C24DD2" modified="2018-04-25" version="1">MQSPAPSSPHRSAPTGPTADPAQRGLLTERIARQLEHDIRSGEIAVGAKLPSERELAAQFGSSRNVVREVLRRLEAQHLIEVAPGRGSFVREQTSGQARGYDALYRAGRPTVRQLIEARLPLEVEMVRLATQHATDEDLATMRQACDALESATDVVVKAQADMDFHDAVAVASKNPVLRIMLSSISGMMFEMMLRSNSDPSIGEEGVPHHPEIFEAIEARDVELAGARMREHLMLGLRTYGPDLDVQVDTMARNHIETLLERAARGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JRL3</accession>
    <name>A0A2M9JRL3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Alpha/beta hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CG723_22405</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000008">
        <property type="protein sequence ID" value="PJN09509.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN09509">
        <property type="protein sequence ID" value="PJN09509"/>
        <property type="gene ID" value="CG723_22405"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014896381" evidence="2">
        <location>
            <begin position="38"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="297"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="domain" description="AB hydrolase-1" evidence="3">
        <location>
            <begin position="48"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PJN09509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="324" mass="33598" checksum="AC1A5705CF2959A0" modified="2018-04-25" version="1">MAAFPVPGSRRRIRRAHVMAAGCAVALCTGVAAPVAADGGTTTAKPTIVLVHGAFADASSWNGVVERLQRRGYSVIAPANPLRGLYSDSAYIASVLDSIKGPIVLAGHSYGGALISTAAEGNPQVKSLVYVSALMPDVGESGMTLGAKFPSELGTATKSVPYRAGGVSGTDLYLKPDRIHPVFAADLPESTTRVMAVTQRPAATTAFSETAKVAAWKHIPSWFLVAKQDKTINPDQERFEAKRAGSHMVEIDSSHVAMISHPDAVTDLVLQAATAADSARPALAATGTTHDARAETVLTGIAAASLIAGTGAVLLGRRLKRSRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JRP4</accession>
    <name>A0A2M9JRP4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Urea carboxylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_22590</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000008">
        <property type="protein sequence ID" value="PJN09534.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN09534">
        <property type="protein sequence ID" value="PJN09534"/>
        <property type="gene ID" value="CG723_22590"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018959">
        <property type="entry name" value="DUF1989"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017792">
        <property type="entry name" value="Urea_carboxylase-assoc_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09347">
        <property type="entry name" value="DUF1989"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03425">
        <property type="entry name" value="urea_degr_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF1989" evidence="1">
        <location>
            <begin position="25"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF09347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN09534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="253" mass="26731" checksum="C74FB760AC2B7E80" modified="2018-04-25" version="1">MPVLPASSWPTPPEGIAAEDLVWAETVAGGNYTHKVLARGTELRLTDLTGDACAHVLLYSADRPWERLNAADTVKVFWNAYLGEGHLLLSDQGRVLASVTEDASGRHDALSGTSALVRNTERYGDGTPQSATPAGRELFKLAALKNGLGPRDIPPSVSFFQGVRVSEDGTACFTGSAGAGTSVTLRAEQPLTVLIANVPHPLDPRPAYICGPLEVLAYRAAPTAPGDALWDATPEGRRAFLNTAEHLNARGIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JS03</accession>
    <name>A0A2M9JS03_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_22855</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000008">
        <property type="protein sequence ID" value="PJN09638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN09638">
        <property type="protein sequence ID" value="PJN09638"/>
        <property type="gene ID" value="CG723_22855"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="48"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="75"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN09638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="124" mass="13013" checksum="04F2DC60F0F3D442" modified="2018-04-25" version="1">MITGATLFAVVALLVSGPLSILLGASGIAGDTVFASSRYAYRFDLTAWGWIHLVIGVALVVAGLGVAAGRTWGRGAGIAVAAISLITQFMFIPYYPAWSITVMALDLLIVWSLTRFSHTPSAGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JS61</accession>
    <name>A0A2M9JS61_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA primase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_21190</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000007">
        <property type="protein sequence ID" value="PJN09720.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN09720">
        <property type="protein sequence ID" value="PJN09720"/>
        <property type="gene ID" value="CG723_21190"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015330">
        <property type="entry name" value="DNA_primase/pol_bifunc_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09250">
        <property type="entry name" value="Prim-Pol"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00943">
        <property type="entry name" value="Prim-Pol"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Prim-Pol" evidence="1">
        <location>
            <begin position="34"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN09720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="225" mass="23217" checksum="445FCD64F7517927" modified="2018-04-25" version="1">MGFTIGGSRGILDIRSGARRRGRTSGRASDCTSVAEFTGLWGWDAVPGARASGGACSCGKTNCIQPGAHPIDHAPTVPAGATLDEVTETWEQFPGAAVMLPVGSAFDIIDVPEAAGRRALVRLERMGLPLGPVTATPEGRAHFFVAPGSAAELGSLLYRMGWDDAALDLHALGPGTHITAPPSDRGGLGPVRWLRAPGLDSATQPPQARLVLGTLAYVAHRSPAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JSJ4</accession>
    <name>A0A2M9JSJ4_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HTH luxR-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_20735</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000007">
        <property type="protein sequence ID" value="PJN09846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN09846">
        <property type="protein sequence ID" value="PJN09846"/>
        <property type="gene ID" value="CG723_20735"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041664">
        <property type="entry name" value="AAA_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13191">
        <property type="entry name" value="AAA_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH luxR-type" evidence="2">
        <location>
            <begin position="948"/>
            <end position="1013"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN09846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="1019" mass="110434" checksum="4EA2D61239EF8667" modified="2018-04-25" version="1">MLPPVETRCVSPVFVGRAGELGVLNKALARATTGEPQAMLLGGEAGVGKTRLVEEFALAARREGTVVALGGCVEIGADGLPFAPFSTALRALRRLLPEEFVAAAAGQETELARLLPELSPAPTGRDGRHDEQSMARLFELTARLLERVAADRTVLVILEDLHWADASTRHLLSYLFRTLRSGRLVIVATYRADDIHRRHPLRPLLAELDRLRTVTRLELDRFSRDEVSRQIAGIFAAEPEQAQVDDIFERSDGNAFFVEELAVATSGGNCTGLSETLRDVLLVRVESLPDDAQRVARIVAEGGSTVEYALLAAVARLGEDELIEALRAAVGANILLATPDGDGYRFRHSLVREAVGDDLLPGERSRLSRRYAEALEADPSLVRADERVTRLASYWYHAHDPAKALPAVLDASVEARRRHAYSEQLRLLERAMSLWDEAPEDIRAALRPVDYTEVYPPCGCDPATTPLRYLDLMAEAAVAGRLCGERERALKIIKRALRLIDDADDEKDPLRAAWFWIQRSRLVSSLGRGDGWAEIATAQELVRGLPPSEVHAEVLTNVASWGMLHNPGEETLAAAERAVEYARMVKAEDIELNARLTLGGLLVDAGEIDRGFAEMYAVRDRVVEIGLVPQVGRVHINLASVLEGAGRSLESVTVAESGMDLCRRYGLLDTEGWVLTNMAESLTSLGRWTEAEVAVDTALRSSALSAKPRGTAATRLAAVALARGDHAEAAAQLATARAHYGSHDTMPQYTLPLSALAVGISAAAGGTQGLLDARAELARVVAEGVPPSNQRYAWTLLVSAAVAEADARGLPAAEPGRAAAVDRIRTAAKRLATPMPVWLAHEQWLRAELLRAEGRDTPDDWSHPLTTFESLDRPYDLARVRFRAAESLLAAAATFDDERERATELLRLAGAVADHLGARPLTESVALLAQRARLTLNPAAPRPQMPADPAEELGLTSRERDVLRLVAAGRSNRQIAEELFISPKTASVHVSNILAKLGVAGRGEAAAVAHRLRLFAPTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-05-25" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JSR9</accession>
    <name>A0A2M9JSR9_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 16">Succinate dehydrogenase flavoprotein subunit</fullName>
            <ecNumber evidence="5 16">1.3.5.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">CG723_19530</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">CB01635</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 16">
            <text>a quinone + succinate = a quinol + fumarate</text>
            <dbReference type="Rhea" id="RHEA:40523"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:29806"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
            <dbReference type="EC" id="1.3.5.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 16">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 16">Carbohydrate metabolism; tricarboxylic acid cycle; fumarate from succinate (bacterial route): step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 16">Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.5.1" evidence="5 16"/>
    <dbReference type="EMBL" id="NNBL01000006">
        <property type="protein sequence ID" value="PJN09929.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN09929">
        <property type="protein sequence ID" value="PJN09929"/>
        <property type="gene ID" value="CG723_19530"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00223">
        <property type="reaction ID" value="UER01005"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033765">
        <property type="term" value="F:steroid dehydrogenase activity, acting on the CH-CH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008177">
        <property type="term" value="F:succinate dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022900">
        <property type="term" value="P:electron transport chain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008202">
        <property type="term" value="P:steroid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.700.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003953">
        <property type="entry name" value="FAD-binding_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003952">
        <property type="entry name" value="FRD_SDH_FAD_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037099">
        <property type="entry name" value="Fum_R/Succ_DH_flav-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015939">
        <property type="entry name" value="Fum_Rdtase/Succ_DH_flav-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030664">
        <property type="entry name" value="SdhA/FrdA/AprA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027477">
        <property type="entry name" value="Succ_DH/fumarate_Rdtase_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011281">
        <property type="entry name" value="Succ_DH_flav_su_fwd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014006">
        <property type="entry name" value="Succ_Dhase_FrdA_Gneg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11632">
        <property type="entry name" value="PTHR11632"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00890">
        <property type="entry name" value="FAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02910">
        <property type="entry name" value="Succ_DH_flav_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46977">
        <property type="entry name" value="SSF46977"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56425">
        <property type="entry name" value="SSF56425"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01816">
        <property type="entry name" value="sdhA_forward"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01812">
        <property type="entry name" value="sdhA_frdA_Gneg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00504">
        <property type="entry name" value="FRD_SDH_FAD_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="17" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="11 16" id="KW-0249">Electron transport</keyword>
    <keyword evidence="10 16" id="KW-0274">FAD</keyword>
    <keyword evidence="9 16" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="13 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="12 16" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 16" id="KW-0813">Transport</keyword>
    <keyword evidence="8 16" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="FAD_binding_2" evidence="18">
        <location>
            <begin position="7"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="domain" description="Succ_DH_flav_C" evidence="19">
        <location>
            <begin position="454"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="17">
        <location>
            <begin position="467"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="14">
        <location>
            <position position="286"/>
        </location>
    </feature>
    <feature type="modified residue" description="Tele-8alpha-FAD histidine" evidence="15">
        <location>
            <position position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00019965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR611281-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR611281-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU362051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF00890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF02910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="PJN09929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="584" mass="64853" checksum="2485EDBFD046F110" modified="2018-04-25" version="1">MKIHKYDTVIVGAGGAGMRAAIESTKRSRTAVLTKLYPTRSHTGAAQGGMAAALANVEEDNWEWHTFDTIKGGDYLVDQDAAEILAKEAIDSVLDLEKMGLPFNRTPDGTIDQRRFGGHSRNHGEAPVRRSCYAADRTGHMILQTLYQNCVKEGVEFFNEFYVLDQLITEIDGVKHSAGVVAYELATGEIHIFQAKSVIYASGGTGKFFKVTSNAHTLTGDGQAACYRRGLPLEDMEFFQFHPTGIWRMGILLTEGARGEGGILRNKDGERFMEKYAPVMKDLASRDVVSRSIYTEIREGRGCGPEGDHVYLDLTHLPPEQLDAKLPDITEFARTYLGIEPYTDPIPIQPTAHYAMGGIPTNVEGEVLSDNTTVVPGLYAAGEVACVSVHGANRLGTNSLLDINVFGRRAGIAAAEYSEKADYVELPEDPASMVVAQVERLRNSTGTERVAVIRNELQECMDANVMVFRTEQTIKTAVEKIAELRERYRNVSIQDKGKRFNTDLLEAIELGNLLDLAEVMATSALARKESRGGHYREDFPNRDDVNFMRHTMAYREVGDDGSESIRLDYKPVVQTRYQPMERKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JTC6</accession>
    <name>A0A2M9JTC6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Polysaccharide deacetylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_20045</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000006">
        <property type="protein sequence ID" value="PJN10151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN10151">
        <property type="protein sequence ID" value="PJN10151"/>
        <property type="gene ID" value="CG723_20045"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002509">
        <property type="entry name" value="NODB_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01522">
        <property type="entry name" value="Polysacc_deac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="SSF88713"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51677">
        <property type="entry name" value="NODB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NodB homology" evidence="2">
        <location>
            <begin position="124"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="27"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN10151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="304" mass="32444" checksum="20840FF4A050BAA6" modified="2018-04-25" version="1">MAAGVLAPALLTGCAPSVDPIERLSRKAAEKVRHSGHPEPTATPAVGVGRGSSWGALGAGEAAGGPGHAAPLHSPQGGVTPDAYRRWGLSAPLAPAPRPPARHAAGRGSHTLPPVVDRVRTKDRVVFLTFDDGVDRDPHFADMVRDLRLPVSVFLTDGVVGPGHDHFGTLRALGAGVQNQTLNHHSLPSLPYAEQHAEICGQQDRLKNRFGTRPRLFRPPFGEYDQDTLRAAATCGVDAVVLWRASTRGEDLSDGDRLRPGDIVRARFTDRAGPHGATLTGMTVRLLRRIQAQGFTVGRLENYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JTT7</accession>
    <name>A0A2M9JTT7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">FMNH2-dependent monooxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CG723_17810</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CB01635</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the NtaA/SnaA/DszA monooxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000005">
        <property type="protein sequence ID" value="PJN10248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN10248">
        <property type="protein sequence ID" value="PJN10248"/>
        <property type="gene ID" value="CG723_17810"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011251">
        <property type="entry name" value="Luciferase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036661">
        <property type="entry name" value="Luciferase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016215">
        <property type="entry name" value="NTA_MOA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00296">
        <property type="entry name" value="Bac_luciferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000337">
        <property type="entry name" value="NTA_MOA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51679">
        <property type="entry name" value="SSF51679"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="2" id="KW-0288">FMN</keyword>
    <keyword evidence="4" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bac_luciferase" evidence="3">
        <location>
            <begin position="23"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="60"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="104"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00033748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000337-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PJN10248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="405" mass="44313" checksum="BB60D6FBCB768C28" modified="2018-04-25" version="1">MLPSSSSALHLAVALDGAGWHPAAWREQVSRPRELFTARYWTDLVQEAERGLLDFVTIEDGLGPQSSHFTEPDARTDQVRGRLDAVLIAARVAPLTRHIGLVPTVVATHTEPFHISKAIATLDYVSSGRAGLRVQVSARRNEAAHFGRRTFPALRIEDLDSPEAKELTGDLFDEASDYVEAVRRLWDSWEDDAEIRDVATGRFIDRDKLHYIDFEGRHFSVKGPSITPRPPQGQPVVSALAHRSVPFQLVARSTDIGYVTPHDADQARAIVDEIRTAQAAAGRSDEPVHVFGDLVVFLDDDPAAAAARRERLDGLAGYAYAGDARIFTGTPAQLADLLQELQQSGLTGFRLRPAVVGHDLPAITQGLVPELQRRGAFRSAYEADTLRGLLGLTRPANRYAAATTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JU05</accession>
    <name>A0A2M9JU05_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_17905</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000005">
        <property type="protein sequence ID" value="PJN10267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN10267">
        <property type="protein sequence ID" value="PJN10267"/>
        <property type="gene ID" value="CG723_17905"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="65"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="98"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="324"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="34"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="112"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN10267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="365" mass="39402" checksum="5D0B368ACBF1CE6C" modified="2018-04-25" version="1">MSKGGASISDEEWERFQREAEAGTQGAPEEPSARARMVTRRLREETHRPAGWRTHEPARQRRGKGWYVVGLLVAAGMLFVALDPGRVTDWFGGVGGGDTPLAAESERPGQPPATESAAQQPTLQQPFRGSPAAQWGDGTAGITVPEARATGWMSKAQVSQALDKSRDFLAASNLDSGVLLGRPPEKAIALINPDQRDVQDYLATAFRAPSQDDDPLLLFSRFATEKVRLVGDVVKTRGRITYREGERGAVEVTTDVTYVYPVAHAAEGRDEVARTIVRREVVMSWDDPAKVITEPGTFSLVSYKSDTANGGCDNDTGFYVPEFPSARAVSGPGSGPEVDPYDRSTSMEARMQGADDAECGTATRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-06-02" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JUL6</accession>
    <name>A0A2M9JUL6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_15315</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000004">
        <property type="protein sequence ID" value="PJN10586.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN10586">
        <property type="protein sequence ID" value="PJN10586"/>
        <property type="gene ID" value="CG723_15315"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="103"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="107"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN10586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="123" mass="12936" checksum="27DB6F6F9B790AF2" modified="2018-04-25" version="1">MSAGGFCKLPNGTVVVALTVPSPTPDDGAVRVLVHAANRARALTRLRNLGLRAIYLRGNAEPPTPDEITAVLHHPDGLLWRAAPHCTAGELWHPIRALLRPRQPGRAGYSSSASTPAPSPSGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JUN4</accession>
    <name>A0A2M9JUN4_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">10 kDa chaperonin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CG723_15425</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CB01635</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Together with the chaperonin GroEL, plays an essential role in assisting protein folding. The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding. GroES binds to the apical surface of the GroEL ring, thereby capping the opening of the GroEL channel.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Heptamer of 7 subunits arranged in a ring.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the GroES chaperonin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000004">
        <property type="protein sequence ID" value="PJN10606.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN10606">
        <property type="protein sequence ID" value="PJN10606"/>
        <property type="gene ID" value="CG723_15425"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00320">
        <property type="entry name" value="cpn10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.33.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020818">
        <property type="entry name" value="Chaperonin_GroES"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037124">
        <property type="entry name" value="Chaperonin_GroES_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10772">
        <property type="entry name" value="PTHR10772"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00166">
        <property type="entry name" value="Cpn10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00297">
        <property type="entry name" value="CHAPERONIN10"/>
    </dbReference>
    <dbReference type="SMART" id="SM00883">
        <property type="entry name" value="Cpn10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0143">Chaperone</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PJN10606.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="118" mass="12968" checksum="4091082B6D805B63" modified="2018-04-25" version="1">MSANSEKNSTQHDKLPIRMLHDRVLVRQDTAEGERRSGGGILIPATAAVGRRLAWAVVVAVGQNVRTVEPGDRVLYDPEDLAEVEVRGVAYVLMRERDLHAVAADRFEGSQDSTGLYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JV24</accession>
    <name>A0A2M9JV24_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_15550</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000004">
        <property type="protein sequence ID" value="PJN10627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN10627">
        <property type="protein sequence ID" value="PJN10627"/>
        <property type="gene ID" value="CG723_15550"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043917">
        <property type="entry name" value="DUF5753"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19054">
        <property type="entry name" value="DUF5753"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="9"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN10627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="264" mass="29241" checksum="04C0A79962B12FC4" modified="2018-04-25" version="1">MSNTYGEWLKAQREAAGVTQQELATAAVMTRSHISHIEAGRRLPSKADARRLDKALNTGNVLSSFLPDSDGAVAEHFESAHALEQQAVELREFALSFVPGILQTERYARAVLSPSYPPVRQKECDRLVVTRLERAKILEDPVSPVVWALLDEAVLGRPIGGPDVMAEQIMHIVRLAESGRVRVHVLPRSLGFHPLLESMLTLMWFDDQPPVAYSEGVRMGKVHDSPAMVQELQGRYDLALSDALPLKESLALLRATAKDYGHHD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JW23</accession>
    <name>A0A2M9JW23_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Integrase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CG723_08545</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN11028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN11028">
        <property type="protein sequence ID" value="PJN11028"/>
        <property type="gene ID" value="CG723_08545"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PJN11028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="150" mass="17113" checksum="345AC0A6640080D1" modified="2018-04-25" version="1">MPLENTIRDLPWQFPDQKTGPHSICDDPSTPLSTVAALIRTPITMPPAVQRSRVATHAEVLALRHENAVLGRHTARVRHEPAHRIRLATLSRFVPHERRRQAFTITPLLAWHRQLIARKGTFTRHHRPGRPCTAPAVKQLILRWVVVSRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-09-29" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JWI7</accession>
    <name>A0A2M9JWI7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Beta-ketoadipyl CoA thiolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CG723_09850</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CB01635</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the thiolase-like superfamily. Thiolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN11234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN11234">
        <property type="protein sequence ID" value="PJN11234"/>
        <property type="gene ID" value="CG723_09850"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00751">
        <property type="entry name" value="thiolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002155">
        <property type="entry name" value="Thiolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020615">
        <property type="entry name" value="Thiolase_acyl_enz_int_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020610">
        <property type="entry name" value="Thiolase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020617">
        <property type="entry name" value="Thiolase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020613">
        <property type="entry name" value="Thiolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020616">
        <property type="entry name" value="Thiolase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02803">
        <property type="entry name" value="Thiolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00108">
        <property type="entry name" value="Thiolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000429">
        <property type="entry name" value="Ac-CoA_Ac_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01930">
        <property type="entry name" value="AcCoA-C-Actrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00098">
        <property type="entry name" value="THIOLASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00737">
        <property type="entry name" value="THIOLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00099">
        <property type="entry name" value="THIOLASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Thiolase_N" evidence="5">
        <location>
            <begin position="7"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="domain" description="Thiolase_C" evidence="6">
        <location>
            <begin position="274"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-thioester intermediate" evidence="3">
        <location>
            <position position="90"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="3">
        <location>
            <position position="351"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="3">
        <location>
            <position position="381"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000429-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PJN11234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="395" mass="41396" checksum="60F9E19452368A9F" modified="2018-04-25" version="1">MRPVHFAAARRTPIGKLRGSLSTVRPDDLAAGVIRGLLAGVPELDPARIDDVYWGAANQAGEDNRNIARMAALLAGLPESVPGATVNRLCASGLEAVTTAARTIASGEADVVLAGGSESMSRAPFVLQRPDEALPHKMETYDTRLGWRLVNPKMKELHGVLAMGETAEEVAERYDVPRERQDAFALRSHHNAAEARKNGLFDAEILPVTRPDGVVVDQDECIRPDTSLEKLGTLKPVFRKGGTVTAGNASPMNDGAAGLLLVSEEALHDLGLESLGRYVAGASAGVHPDVMGIGPVPATQKALARVGWSVADIQEAEFNEAFAAQALACVDALGIDPELVNPTGGAIALGHPLGCSGARILTTLLHRMRRTGGSRGLATMCIGVGQGSAVLVERS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JX92</accession>
    <name>A0A2M9JX92_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 5">Xylulose kinase</fullName>
            <shortName evidence="3 5">Xylulokinase</shortName>
            <ecNumber evidence="3 5">2.7.1.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3 5 8" type="primary">xylB</name>
        <name evidence="8" type="ORF">CG723_11375</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CB01635</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the phosphorylation of D-xylulose to D-xylulose 5-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3 5">
            <text>ATP + D-xylulose = ADP + D-xylulose 5-phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10964"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17140"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57737"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.17"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="3 4">Belongs to the FGGY kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.17" evidence="3 5"/>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN11496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN11496">
        <property type="protein sequence ID" value="PJN11496"/>
        <property type="gene ID" value="CG723_11375"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004856">
        <property type="term" value="F:xylulokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042732">
        <property type="term" value="P:D-xylose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005998">
        <property type="term" value="P:xylulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02220">
        <property type="entry name" value="XylB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000577">
        <property type="entry name" value="Carb_kinase_FGGY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018485">
        <property type="entry name" value="Carb_kinase_FGGY_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018483">
        <property type="entry name" value="Carb_kinase_FGGY_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018484">
        <property type="entry name" value="Carb_kinase_FGGY_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006000">
        <property type="entry name" value="Xylulokinase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02782">
        <property type="entry name" value="FGGY_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00370">
        <property type="entry name" value="FGGY_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000538">
        <property type="entry name" value="GlpK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01312">
        <property type="entry name" value="XylB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00933">
        <property type="entry name" value="FGGY_KINASES_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00445">
        <property type="entry name" value="FGGY_KINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 3 5" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="3 4 8" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0808">Transferase</keyword>
    <keyword evidence="1 3 5" id="KW-0859">Xylose metabolism</keyword>
    <feature type="domain" description="FGGY_N" evidence="6">
        <location>
            <begin position="9"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="domain" description="FGGY_C" evidence="7">
        <location>
            <begin position="257"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="3">
        <location>
            <begin position="81"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="3">
        <location>
            <position position="239"/>
        </location>
    </feature>
    <feature type="site" description="Important for activity" evidence="3">
        <location>
            <position position="13"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU364073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PJN11496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="479" mass="49084" checksum="6FA4F93F580844B8" modified="2018-04-25" version="1">MSSADGPLVVGVDSSTQSTKALVVDAATGAVVASGQAPHTVSSGQGRESDPEQWWTALCEALRQCGDAAHRASAVSVGGQQHGLVTLDAAGRPVRPALLWNDVRSAPQARRLIDEMGGPKAWAERVGSVPGASFTVSKWAWLAEHEPDAVRATAAVRLPHDYLTQRLTGDGTTDRGDASGTGWWASATESYDDDILARVGLDPALLPRVVRPGEVAGTVHGSGELPFSRGTLVAAGTGDNAAAALGLGLRPGTPVLSLGTSGTVYAVSRHRPADPTGTVAGFADARGDWLPLACTLNCTLAVDRVAALLGLDREAVEPGGDITLLPYLDGERTPDLPNASGLLHGLRHDTTGGQLLQAAYDGAVHALLGALDLVLDADADLSVPLLLIGGGARGTAWQQTVRRLSGRAVQVPEARELVALGAAAQAAGLLTGEDPAAVARRWGTAQGPVLDPVEQDAAALARISGVLSDAAPLLDRGPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JXA1</accession>
    <name>A0A2M9JXA1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Short-chain dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CG723_11480</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN11515.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN11515">
        <property type="protein sequence ID" value="PJN11515"/>
        <property type="gene ID" value="CG723_11480"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PJN11515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="263" mass="26860" checksum="0CF7356798F81615" modified="2018-04-25" version="1">MSNTNTPAPVSDYATEFAGRTALVTGAASGIGLATARRLGRGGANAVIADYNADGAEKAAAELKAEGIIAAAVAVDVTKPESVEAAVKFSVDTFGGLELAVNNAGIGGESAPTGDYDIDVWNRVLRTNLDGVFYSMRHELPAIEASGKGGAIVNVASILGSVGFAGSPAYVAAKHGVVGLTKTAATEYAAKGIRVNAVGPGFIDTPLLRQMDQDAYDALTALHPAGRLGHAEEVAELIAFLLSDRASFVHGSYHLVDGAYTAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JXF4</accession>
    <name>A0A2M9JXF4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CG723_11765</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN11565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN11565">
        <property type="protein sequence ID" value="PJN11565"/>
        <property type="gene ID" value="CG723_11765"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PJN11565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="138" mass="15469" checksum="069A2D5EAB2F7833" modified="2018-04-25" version="1">MHEEFLCHVTAYGICGGQRVGVPLGTYRAPTLPLAMWWLRDRASWIAERLDPRPGNPHFPEHAIAPVADTVPDVPGALRDWCGDVERQEQVAEELADGNLVRLITRDDTTEYEFLAESIDALRMQRTRASRAALVPHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JXY6</accession>
    <name>A0A2M9JXY6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CG723_12835</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN11739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN11739">
        <property type="protein sequence ID" value="PJN11739"/>
        <property type="gene ID" value="CG723_12835"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PJN11739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="138" mass="15506" checksum="DE2AF24D07C6431A" modified="2018-04-25" version="1">MTIPGSVGPTEYIRFQAVSPNERGHFTGVFGLVNRLGRAGRLSEEQELFRRENNAWYDLAYPDPSKVDPSVYDPAVNPTATAWFKPTATHLMERVDGYLEILAAHGVDCRLVRSRDPGQVIYEDEVQIVVVTRRESNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JY45</accession>
    <name>A0A2M9JY45_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Aldehyde dehydrogenase PuuC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CG723_13155</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CB01635</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN11792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN11792">
        <property type="protein sequence ID" value="PJN11792"/>
        <property type="gene ID" value="CG723_13155"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016620">
        <property type="term" value="F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016160">
        <property type="entry name" value="Ald_DH_CS_CYS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="SSF53720"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00070">
        <property type="entry name" value="ALDEHYDE_DEHYDR_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00687">
        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldedh" evidence="5">
        <location>
            <begin position="34"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="266"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PJN11792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="496" mass="52482" checksum="DE20DECCC72778AA" modified="2018-04-25" version="1">MLELTHDEWLSRAKELDLSGFHHIDGSDEPGGGATYAAVSPCDGQILAQVADGGAAEVDAAVAAARRAFDAGPWPRLAPADRGRALLRLADLLEERRDRLALTVSLEMGKPITDAYDIELRAAVNTFRFYGQLADKLTDESPHTAPDALALVTREPAGVVGAVVPWNFPLTIASWKVAPALAAGCTVVLKPSESSPLSALQLGRLATEAGLPPGVLNVVTGDGPTAGRAIGLHPDVDVLAFTGSTAVGRHFLHYAADSNLKRVWLELGGKSPNIILPDAPDLEKAAATAAWGIFFNQGEMCTAPSRLLVHTSVAERVTEAIVRRAGELRVGDPLDPATEMGALVGEAHLGRVLDHIDTGTSEGARLRTGGTRTLTDTGGSFLQPTVFDEVNPGMRLAREEIFGPVLSVLTFDDLDEAVALANATEYGLAAGLWTSDLSTAHQVSRALKAGTVWVNCYEEGDLTVPFGGMKQSGNGRDKSAHALEKYTELKTTWIQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JY50</accession>
    <name>A0A2M9JY50_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Proline hydroxylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CG723_13180</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN11794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN11794">
        <property type="protein sequence ID" value="PJN11794"/>
        <property type="gene ID" value="CG723_13180"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018655">
        <property type="entry name" value="DUF2086"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09859">
        <property type="entry name" value="Oxygenase-NA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PJN11794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="243" mass="27381" checksum="67D0D2CC4675AF9B" modified="2018-04-25" version="1">MLDTTRLTGPVADRVAHEEWGALADELNTYGNAPTGRLLTPEECRRIAGLYDDAERFRTTVDMARHRFGSGQYRYFTHELPHVVRELREAFYPRLLPIARDWAEKLGKPAPWPDSLDEWIEMCHTAGQDRSAQILLRYGPGDWNALHRDVFGDMLFPLQVVIGLDAPGTDFTGGEFLMTEQRARAQSRGSSTTLLQGHGLIFTTRDRPVASKRGWSNAPMRHGVSTVRTGQRHTLGLVFHDAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JYE7</accession>
    <name>A0A2M9JYE7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Acetoacetate decarboxylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CG723_13125</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN11787.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN11787">
        <property type="protein sequence ID" value="PJN11787"/>
        <property type="gene ID" value="CG723_13125"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016831">
        <property type="term" value="F:carboxy-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.400.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010451">
        <property type="entry name" value="Acetoacetate_decarboxylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023375">
        <property type="entry name" value="ADC_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06314">
        <property type="entry name" value="ADC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160104">
        <property type="entry name" value="SSF160104"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0704">Schiff base</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PJN11787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="268" mass="29381" checksum="DB19E10B6C5668D0" modified="2018-04-25" version="1">MASVRGYFHPKTATGDASLIPSPPWHYSGDLLTVEYRTDPARVRELLPEPLELADEDPGAVALIWADWQSCAADGSQLLDPVLAQYKEAFAVVRCQYKGRTYSRCVYIWVDKDFAVARGLHQGYPKKLGSIHQTRPHPYGPAPRIEAGARFGATLAAADRRLAQAVVTLREPSETNGFVNSHPMAHHRWLPSIEKGKGLALDELIETGAASFEAGQAWVGDAELELFEAPTEELARLEIREPIAAYYRQVGVVWDGGTLLESGTSGAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JYK9</accession>
    <name>A0A2M9JYK9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Stress responsive protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_14185</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN11960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN11960">
        <property type="protein sequence ID" value="PJN11960"/>
        <property type="gene ID" value="CG723_14185"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013097">
        <property type="entry name" value="Dabb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07876">
        <property type="entry name" value="Dabb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00886">
        <property type="entry name" value="Dabb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51502">
        <property type="entry name" value="S_R_A_B_BARREL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Stress-response A/B barrel" evidence="1">
        <location>
            <begin position="87"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN11960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="199" mass="21533" checksum="72954FD466AE79D4" modified="2018-04-25" version="1">MTRWVALLPDDDTEAYSKAAVAGTGVLGGSAAADLPGSFGGTGATWDVTADRTPTDIAAEAGLPEPLDTVALAQVRRGYVPLRGPRVKRTLLLAVRPGTPGALVGQLEADLMAMPEHISTIRSWSLSTVDQTLTPSHWTHVWEQEYADVQGLTGEYLGHPFHWTCVDRWFDGEIPTAGIVEPRLVHVFRWSREPILASP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JYW9</accession>
    <name>A0A2M9JYW9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">TetR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_14875</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN12075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN12075">
        <property type="protein sequence ID" value="PJN12075"/>
        <property type="gene ID" value="CG723_14875"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="8"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="31"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN12075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="187" mass="20302" checksum="5FBDCB62A4D405F6" modified="2018-04-25" version="1">MPTPRGDAQRREQVLATALTVFATFGYRKTSMDAVAQAADISRPGLYFLFSSKQELFRATMRQELDKALEDVRAALAAPDSDLDARLVAALDAHLGRYVGTNLDEGVDALLEHDTTKLDSMYDDYRAAFRDALAGAISASGGTTGDVTPRQIAEVLAAAGEGWKHRVSDRPQFRDKLTLAVAVAMRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JYY1</accession>
    <name>A0A2M9JYY1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cupin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_08570</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN12093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN12093">
        <property type="protein sequence ID" value="PJN12093"/>
        <property type="gene ID" value="CG723_08570"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013096">
        <property type="entry name" value="Cupin_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07883">
        <property type="entry name" value="Cupin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cupin_2" evidence="1">
        <location>
            <begin position="41"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN12093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="145" mass="15729" checksum="7EDFBBAA46BBD21A" modified="2018-04-25" version="1">MSAKNPEHGSAHEVSLPPEVKLLQEVTPPFFPEGGSGMTILVEWPPGHPGLPPHRHSGPSFGYVMEGAVRFELEGEPERVVEAGGTFWEPGGDVIHYQDGNALSDASTKFVVTMVCAPGQPMLRLVDEEELKERAHLRAPRPSEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JZT8</accession>
    <name>A0A2M9JZT8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">DoxX family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CG723_04175</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CB01635</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000002">
        <property type="protein sequence ID" value="PJN12267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN12267">
        <property type="protein sequence ID" value="PJN12267"/>
        <property type="gene ID" value="CG723_04175"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032808">
        <property type="entry name" value="DoxX"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07681">
        <property type="entry name" value="DoxX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="140"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="171"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PJN12267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="193" mass="19355" checksum="98B5637E39004F50" modified="2018-04-25" version="1">MSLPSQENPHVTSLANQLGPLRAPGSPAPAAPAHAYDLGLLVLRLALGLTMAAHGAQKLFGWFGGGGIDGTGQFFAASGYPSPKAFALVAGLSETLGGLGLVLGLLTPLAAAAVVGTLVNAIAVKWGGGFFAPQGIEYELLIALGAVALALTGPGRIAFDRFLPGLRSHRLGYGVAAVALGLVVAGITLVLRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K024</accession>
    <name>A0A2M9K024_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_05430</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000002">
        <property type="protein sequence ID" value="PJN12479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN12479">
        <property type="protein sequence ID" value="PJN12479"/>
        <property type="gene ID" value="CG723_05430"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021454">
        <property type="entry name" value="DUF3105"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11303">
        <property type="entry name" value="DUF3105"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="29"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN12479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="220" mass="23807" checksum="87E7B3EF4A431151" modified="2018-04-25" version="1">MGSAKNTGSATRKARIEEMRRAERSRERLRRVLVVVVSAVVVVCLAGFGAWALMKGDDSKDTADAKSSAGSFKTGSDGVKTWTGKLDRNHVAKKVTYPMTPPVGGDHNQVWMNCNGDVYKKAIPNENAVHALEHGAVWVTYTDKADPGDVQKLAAKVRQTPYSLMSPDQDQKDPIMLSAWGHQRTVKSATDPDVASFFSTFVQGKQTPEPGAACTNGLSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K029</accession>
    <name>A0A2M9K029_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">AfsR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CG723_05345</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CB01635</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AfsR/DnrI/RedD regulatory family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000002">
        <property type="protein sequence ID" value="PJN12464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN12464">
        <property type="protein sequence ID" value="PJN12464"/>
        <property type="gene ID" value="CG723_05345"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd15831">
        <property type="entry name" value="BTAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005158">
        <property type="entry name" value="BTAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03704">
        <property type="entry name" value="BTAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01043">
        <property type="entry name" value="BTAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0902">Two-component regulatory system</keyword>
    <feature type="domain" description="OmpR/PhoB-type" evidence="5">
        <location>
            <begin position="1"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="3">
        <location>
            <begin position="1"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="242"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PJN12464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="1125" mass="121470" checksum="D16F31C6F377049F" modified="2018-04-25" version="1">MRYRILGSTQALRDDGTAVPVGGARLRALLTVLALRPGRTVPPQVLTDEVWGADPPADASGALQALVGRLRRAIGADAVHSLDGGYRLSATSEDIDLFRFERLVRDGVQALADGDPGKSVAVLDDALSLWRGPALADLPDRSADAARWEALHLESRRTRLSASLALGRAESVLPELTALCDAHPLDEPLQALRLRALRDAGRTAEALAAYERVRVELAERLGTDPGPELRALHADLLTPRASAPTASAERPTTPVRAPAHTGNLRARLTSFVGRAGDIGAIREDLGRVRLVTLLGPGGAGKTRLSQETAESMDLPDGVWLAELAPIEDPDAVPEAVVTALGARETVLRGAGAEELRVASDRHGEDPLVRLTEHCAHRRMLLILDNCEHVIEAAARLAEQLLSQCPGVTVLATSREPLGVPGELLHPVEPLPEPFALRLFGERGAAVRPGFRVEDDERAAAEICRRLDGLPLAIELAAARLRMLTPRQIADRLDDRFRLLTSGARTVLPRQQTLRAVVDWSWDLLDEEERTVLRRLSVFSGGCDLAAAEAVCGPGALDAIGSLVDKSLVVAAPWGGGEADHEDHGDHGDCGDYGDGADGEGRDQAGAMRYRLLETVAEYAGDRLDEAGDRADAERAHLTYYRELARTTDPQLRGHGQRAAVARLEREYENLRTALRHAVAARDEQETLSLVLSLAWFWQMRDLRVDARNWSREATALGPDPFAPPAAPAPPLYERCTDAPPPFGPELLVEARRGVHLLRLAYMDMEMETWQTEEGGAKLRAIAQAYRPGLPQTCRPPGNLWFYAVMMSGDMEALWDLADVTVRTCRELGYTWELALTLQLRANILANRSDWAGDAVRDADESLELFTRLGDRWGVAEALSARGEAHERSGAYAAAAEDYAAAIEGAERLGAQAQVAILNARLGQALIEVGDGERGEELLRGILDPGKRHANEAWPAARMFLAGRYGATGRVAEAREQLRLLQDEFKAMSFVVFRGFVVGMKAWLDSEDGLAEEALAGVVEALELATDPLALVIAPHMPAMHLVTGACALSLSGDPAAARDAARLVGAADGQLPSRHVRSYLERDAHTSAEAAIREVIGDRAYEAAYAEGGDLSLDEAAALLGRERG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K088</accession>
    <name>A0A2M9K088_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MOSC domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_05195</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000002">
        <property type="protein sequence ID" value="PJN12437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN12437">
        <property type="protein sequence ID" value="PJN12437"/>
        <property type="gene ID" value="CG723_05195"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030151">
        <property type="term" value="F:molybdenum ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005302">
        <property type="entry name" value="MoCF_Sase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011037">
        <property type="entry name" value="Pyrv_Knase-like_insert_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03473">
        <property type="entry name" value="MOSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50800">
        <property type="entry name" value="SSF50800"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51340">
        <property type="entry name" value="MOSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MOSC" evidence="1">
        <location>
            <begin position="22"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN12437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="185" mass="19528" checksum="9B6CFC003D546622" modified="2018-04-25" version="1">MGRFDGGTVIAVSSNETYSFTKPNRESITLLAGLGVDGDVHAGVTVKHRSRVAKDPTQPNLRQVHLMHEELFAEVAEQGHDVAPGDLGENVTTTGIDLLALPAGTLLHLGEGGAVVEVTGLRNPCRQIDHFQDGLLKRVVGRDENGAIVRKGGIMSVVRTGGVVRPGDAIRVVLPAEPHVALEAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K0U1</accession>
    <name>A0A2M9K0U1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Acyl-CoA dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CG723_06615</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CB01635</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000002">
        <property type="protein sequence ID" value="PJN12690.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN12690">
        <property type="protein sequence ID" value="PJN12690"/>
        <property type="gene ID" value="CG723_06615"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016627">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="SSF47203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="SSF56645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0274">FAD</keyword>
    <keyword evidence="3 5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA_dh_N" evidence="8">
        <location>
            <begin position="6"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_M" evidence="7">
        <location>
            <begin position="125"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_1" evidence="6">
        <location>
            <begin position="231"/>
            <end position="374"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PJN12690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="381" mass="41636" checksum="DD4DFE13AA16B3A2" modified="2018-04-25" version="1">MDLDFTPAEDAFRAEAREWLAGHVPSEPLPSLETGEGFAAHRAWEAQLHAGRWSVVSWPEEYGGRGADIFSWLLFEEEYYAAGAPGRVSQNGINLLAPTLFDHGTPEQRARVLPSMASGETIWAQAWSEPEAGSDLASLKSKAVRTEGGWLLSGQKTWSSRAAFADRAFGIFRTDPDAPKPHQGLTYLMFDLRAPGVTVRPIGRLDGKPAFAELFLDRVFVPDDDVIGEPGNGWRIAMSTTGNERGLTLRSPGRFLAAADRLVRLWGERGEDAGIRDRVADALIGARAYQLFTYANASRFAAGQTIGAESSLNKVFWSEYDIALHETALDLLGPDGELADDRGGWGEGYVFSLAGPIYAGTNEIQRDIIAERLLGLPKGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K1K1</accession>
    <name>A0A2M9K1K1_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">SURF1-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CG723_07830</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CB01635</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the SURF1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000002">
        <property type="protein sequence ID" value="PJN12907.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN12907">
        <property type="protein sequence ID" value="PJN12907"/>
        <property type="gene ID" value="CG723_07830"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd06662">
        <property type="entry name" value="SURF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002994">
        <property type="entry name" value="Surf1/Shy1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045214">
        <property type="entry name" value="Surf1/Surf4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23427">
        <property type="entry name" value="PTHR23427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02104">
        <property type="entry name" value="SURF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50895">
        <property type="entry name" value="SURF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="218"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PJN12907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="264" mass="28987" checksum="7D173E91B17330A2" modified="2018-04-25" version="1">MYRFLLSRQWVILTLITLLLIPTMIELGFWQLHRHEHRVAQNDQIGAALAAKPLPAEQLTSPGKPVPKAEIHRRVSAKGTFDTAHEVVVRRRTNTDDEVGFHVLTPFVLDDGKVLLVNRGWIPADGAQTAFPKIPAPARGEITVTGRLMADETTAASGIKDIKGLPDRQIMLISSGQQAKALGKQVLGGFIEQTTPEPRHNTPQLIPTPNHSDIGPHMAYAVQWWLFAAAVPVGFVVLVRRERRDRAEAATAEETPAGPEPATV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K1N4</accession>
    <name>A0A2M9K1N4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="14">CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">pgsA</name>
        <name evidence="14" type="ORF">CG723_00050</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">CB01635</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism; phospholipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="11">Phospholipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the CDP-alcohol phosphatidyltransferase class-I family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000001">
        <property type="protein sequence ID" value="PJN13041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN13041">
        <property type="protein sequence ID" value="PJN13041"/>
        <property type="gene ID" value="CG723_00050"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00053">
        <property type="reaction ID" value="UER00089"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00085"/>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008444">
        <property type="term" value="F:CDP-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1760">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000462">
        <property type="entry name" value="CDP-OH_P_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043130">
        <property type="entry name" value="CDP-OH_PTrfase_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004570">
        <property type="entry name" value="Phosphatidylglycerol_P_synth"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01066">
        <property type="entry name" value="CDP-OH_P_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00560">
        <property type="entry name" value="pgsA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00379">
        <property type="entry name" value="CDP_ALCOHOL_P_TRANSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="7" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="10" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12 14" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="34"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="66"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="158"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00025707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="PJN13041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="226" mass="23971" checksum="2E91E8873C13E974" modified="2018-04-25" version="1">MTGVPASATGGSGRPAPGGKLGAAAVNQASLWNIANILTMVRLLLVPGFVVLLLTDGGYDPVWRAWAWAAFAVAMITDVFDGHLARTYNLVTDFGKIADPIADKAIMGAALICLSSLGDLPWWVTGVILGRELGITLLRFWVIRYGVIPASRGGKMKTLAQGTAVGMYVLALTGPLATFRFWVMAVAVALTVLTGLDYVKQAVVLRRQGMAAERAARDEREAAAEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K1S2</accession>
    <name>A0A2M9K1S2_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">GTPase HflX</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">GTP-binding protein HflX</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5 10" type="primary">hflX</name>
        <name evidence="10" type="ORF">CG723_00260</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CB01635</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="5">Monomer. Associates with the 50S ribosomal subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
        <text evidence="5">May associate with membranes.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. HflX GTPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000001">
        <property type="protein sequence ID" value="PJN13076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN13076">
        <property type="protein sequence ID" value="PJN13076"/>
        <property type="gene ID" value="CG723_00260"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01878">
        <property type="entry name" value="HflX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11060">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00900">
        <property type="entry name" value="GTPase_HflX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030394">
        <property type="entry name" value="G_HFLX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032305">
        <property type="entry name" value="GTP-bd_M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016496">
        <property type="entry name" value="GTPase_HflX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025121">
        <property type="entry name" value="GTPase_HflX_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042108">
        <property type="entry name" value="GTPase_HflX_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10229">
        <property type="entry name" value="PTHR10229"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16360">
        <property type="entry name" value="GTP-bdg_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13167">
        <property type="entry name" value="GTP-bdg_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006809">
        <property type="entry name" value="GTP-binding_hflX_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00326">
        <property type="entry name" value="GTP1OBG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03156">
        <property type="entry name" value="GTP_HflX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51705">
        <property type="entry name" value="G_HFLX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 5 6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3 7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="1 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 5 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hflx-type G" evidence="9">
        <location>
            <begin position="279"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="216"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="24"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="285"/>
            <end position="292"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="292"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="310"/>
            <end position="314"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="312"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="332"/>
            <end position="335"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="398"/>
            <end position="401"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="422"/>
            <end position="424"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR006809-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR006809-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PJN13076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="502" mass="54457" checksum="8ECA3E5E691270DC" modified="2018-04-25" version="1">MTSSSSPSQDAQSFAQNNPEGLRADALMEEDVAWSHEIDGERDGDQFDRSERAALRRVAGLSTELEDVTEVEYRQLRLERVVLVGVWTSGTVNDAENSLAELAALAETAGALVLDGVIQRRDKPDAATYIGSGKALELRDIVLETGADTVVCDGELSPGQLIHLEDVVKVKVVDRTALILDIFAQHAKSREGKAQVALAQMQYMLPRLRGWGQSLSRQMGGGGSSGSGGGMATRGPGETKIETDRRRIREKMAKMRREIAEMKTGREIKRQERKRNKVPSVAIAGYTNAGKSSLLNRLTGAGVLVENALFATLDPTVRRAETPSGRLYTLADTVGFVRHLPHHLVEAFRSTMEEVGESDLILHVVDGSHPAPEEQLAAVREVIRDVGATKVPEIVVINKADAADPLVLQRLLRVEKRAIAVSARTGLGMDKLLAIIDDELPRPEVEIEALVPYTHGQLVARAHADGEVISEEHTPDGTLLKARVHEELAAEFAPYLPAAAAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K1S5</accession>
    <name>A0A2M9K1S5_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 8">Diaminopimelate epimerase</fullName>
            <shortName evidence="8">DAP epimerase</shortName>
            <ecNumber evidence="4 8">5.1.1.7</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">PLP-independent amino acid racemase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">dapF</name>
        <name evidence="10" type="ORF">CG723_00245</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CB01635</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>(2S,6S)-2,6-diaminoheptanedioate = meso-2,6-diaminoheptanedioate</text>
            <dbReference type="Rhea" id="RHEA:15393"/>
            <dbReference type="ChEBI" id="CHEBI:57609"/>
            <dbReference type="ChEBI" id="CHEBI:57791"/>
            <dbReference type="EC" id="5.1.1.7"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 8">Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; DL-2,6-diaminopimelate from LL-2,6-diaminopimelate: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the diaminopimelate epimerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.1.1.7" evidence="4 8"/>
    <dbReference type="EMBL" id="NNBL01000001">
        <property type="protein sequence ID" value="PJN13073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN13073">
        <property type="protein sequence ID" value="PJN13073"/>
        <property type="gene ID" value="CG723_00245"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00034">
        <property type="reaction ID" value="UER00025"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008837">
        <property type="term" value="F:diaminopimelate epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009089">
        <property type="term" value="P:lysine biosynthetic process via diaminopimelate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00197">
        <property type="entry name" value="DAP_epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018510">
        <property type="entry name" value="DAP_epimerase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001653">
        <property type="entry name" value="DAP_epimerase_DapF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31689">
        <property type="entry name" value="PTHR31689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01678">
        <property type="entry name" value="DAP_epimerase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00652">
        <property type="entry name" value="DapF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01326">
        <property type="entry name" value="DAP_EPIMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 8" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6 8" id="KW-0457">Lysine biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="8">
        <location>
            <begin position="86"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="8">
        <location>
            <begin position="209"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="8">
        <location>
            <begin position="219"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="85"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="8">
        <location>
            <position position="85"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="8">
        <location>
            <position position="218"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="15"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="76"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="158"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="191"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Could be important to modulate the pK values of the two catalytic cysteine residues" evidence="8">
        <location>
            <position position="160"/>
        </location>
    </feature>
    <feature type="site" description="Could be important to modulate the pK values of the two catalytic cysteine residues" evidence="8">
        <location>
            <position position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000599"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PJN13073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="292" mass="30471" checksum="84C05D8CBE640685" modified="2018-04-25" version="1">MSTRIAFLKGHGTENDFVIVPDPENALELPPAAVAALCDRRAGIGGDGLLHVVRSAAHPDARHLASEAEWFMDYRNGDGSVAEMCGNGVRVFAHYLQRAGHVGEGDLAVATRGGVKSVHIDKEGDITVGMGKALLPEGDVTVSVADHSWPARNVNMGNPHAVAFVDDLAQAGNLFSAPPFTPATAYPDGVNVEFVVDRGPRRVAMRVHERGVGETRSCGTGACAVAVAAARRDGLDPAVTGSPVTYAVDLPGGQLVITERADGEIEMTGPAVIVAEGEIDTDWLAGLETVNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K1S7</accession>
    <name>A0A2M9K1S7_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Ribonuclease HII</fullName>
            <shortName evidence="11">RNase HII</shortName>
            <ecNumber evidence="11">3.1.26.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">rnhB</name>
        <name evidence="14" type="ORF">CG723_00350</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">CB01635</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3 11 12">Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 11 12">
            <text>Endonucleolytic cleavage to 5'-phosphomonoester.</text>
            <dbReference type="EC" id="3.1.26.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <cofactor evidence="11">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="11">Manganese or magnesium. Binds 1 divalent metal ion per monomer in the absence of substrate. May bind a second metal ion after substrate binding.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 11 12">Belongs to the RNase HII family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.26.4" evidence="11"/>
    <dbReference type="EMBL" id="NNBL01000001">
        <property type="protein sequence ID" value="PJN13092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN13092">
        <property type="protein sequence ID" value="PJN13092"/>
        <property type="gene ID" value="CG723_00350"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004523">
        <property type="term" value="F:RNA-DNA hybrid ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006401">
        <property type="term" value="P:RNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07182">
        <property type="entry name" value="RNase_HII_bacteria_HII_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00052_B">
        <property type="entry name" value="RNase_HII_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022898">
        <property type="entry name" value="RNase_HII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001352">
        <property type="entry name" value="RNase_HII/HIII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024567">
        <property type="entry name" value="RNase_HII/HIII_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10954">
        <property type="entry name" value="PTHR10954"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10954:SF18">
        <property type="entry name" value="PTHR10954:SF18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01351">
        <property type="entry name" value="RNase_HII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8 11 12" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="9 11 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10 11" id="KW-0464">Manganese</keyword>
    <keyword evidence="7 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 11 12" id="KW-0540">Nuclease</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNase_HII" evidence="13">
        <location>
            <begin position="24"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="27"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="28"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="119"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF01351"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="PJN13092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="233" mass="25256" checksum="F12BD929132054FB" modified="2018-04-25" version="1">MPYEPPTHSVERSLRATTGAKIVAGVDEVGRGAWAGPVTVCAAVTGLRRPPEGLTDSKLISPKRREVLAETLESWVTAHALGHASHEEIDELGMTAALRLAAVRALEALPVRPDAVILDGKHNYLGAPWQVRTVIKGDRSCVAVAAASVIAKVRRDKMMAELGIEHADFGFAANAGYPSPVHKAALEVRGPTPYHRLTWAYLDALPQWRHLKKARIWADGNVPEIEGQLGFDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K1W7</accession>
    <name>A0A2M9K1W7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Peptidase M16</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_00510</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000001">
        <property type="protein sequence ID" value="PJN13119.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN13119">
        <property type="protein sequence ID" value="PJN13119"/>
        <property type="gene ID" value="CG723_00510"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011249">
        <property type="entry name" value="Metalloenz_LuxS/M16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011765">
        <property type="entry name" value="Pept_M16_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007863">
        <property type="entry name" value="Peptidase_M16_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00675">
        <property type="entry name" value="Peptidase_M16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05193">
        <property type="entry name" value="Peptidase_M16_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63411">
        <property type="entry name" value="SSF63411"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase_M16" evidence="1">
        <location>
            <begin position="40"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M16_C" evidence="2">
        <location>
            <begin position="192"/>
            <end position="374"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN13119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="461" mass="48786" checksum="BE5D93D33AA5E1F8" modified="2018-04-25" version="1">MTELATMDFHPQPQAGTARPWAFPAPERGTLDNGLTVLRCHRPGQQVVAVEINLEAPLEAEPAGLDGVSTIMARAFSEGTDKLAAEEFAAELERCGATFDAHADHPGVRVSLEVPVSRLPKALGLLADALRAPAFADSEIERLVRNRLDEIPHETANPGRRAAKELSKQLFPATARMSRPRQGTEETVAAVDAAAVRAFYDRHVRPATATAVVVGDLAGIDLDALLADTLGAWTGNTAEPRPVPPVTADDTGRVVIVDRPGAVQTQILIGRIGADKHDRVWPAQVLGTYCLGGTLTSRLDRVLREEKGYTYGVRAFGQVLRSAPDGTGVAMLAISGSVDTPNTGPALDDLWKVLRTLAAEGLTDAERDVAVQNLVGVAPLKFETAAAVAGTLADQVEQHLPDDFQAEVYRRLAATGTVEATAAVVSAFPMDRLVTVLVGDAAQIEEPVRALGIGEVTVVTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K1Y6</accession>
    <name>A0A2M9K1Y6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Thioesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_00615</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000001">
        <property type="protein sequence ID" value="PJN13139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN13139">
        <property type="protein sequence ID" value="PJN13139"/>
        <property type="gene ID" value="CG723_00615"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006683">
        <property type="entry name" value="Thioestr_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03061">
        <property type="entry name" value="4HBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="SSF54637"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4HBT" evidence="2">
        <location>
            <begin position="75"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN13139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="194" mass="20406" checksum="E463E241E0ADB7E1" modified="2018-04-25" version="1">MSGTSAALTPPADAIAPVRHPDAPAPGELLGAHYGHCFGCGDEQPHGLHLAARAQDGVRVTAEFTVRPAHQGAPGLAHGGVLATALDETLGSLNWLLRVIAVTGRLETDFVRPVPVDTVLYLDAEVTAVAGRKIYSTATGRIGGPDGPVAVRAEALFIEVKVDHFIDNGRPEEIQAAMSDPDQVRRTRAFEVNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K271</accession>
    <name>A0A2M9K271_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CG723_01090</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CB01635</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000001">
        <property type="protein sequence ID" value="PJN13215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN13215">
        <property type="protein sequence ID" value="PJN13215"/>
        <property type="gene ID" value="CG723_01090"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001851">
        <property type="entry name" value="ABC_transp_permease"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02653">
        <property type="entry name" value="BPD_transp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="53"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="84"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="135"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="163"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="202"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="245"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="269"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="315"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="351"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="376"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="401"/>
            <end position="418"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PJN13215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="428" mass="44152" checksum="DA6062E1E41D1E85" modified="2018-04-25" version="1">MSIEKTDKPQAPVDAPAVAGDASVAIDPRLLVREQGFAGYISEFKRKMRAGDLGATPVVIGLIVICAIFQSLNSAFLGAENLNNIFVAMVATGMMSVGIIFVLLLGEIDLSVGSVSGVSAAITAVMSVTHGVNEWVAVLAALAAGAVIGALHGFFFARIGAPAFAVTLAGLLFWNGFMLQILGSNGTINIDGDGVVGKLTTYYFSDVAAAYGLAVVAVAGYFLSAFLGNRRREAAGIPSRPLSELVLRTVLLAIAAFAVAIMFNQYKGLPLAVLLFAIVLVATDFVLRRTSYGRKIFALGGSVEASRRAGINVTAVRVSVFAVAGLFAAVGGLFWASKIAAANQSAGSGDLLMNVIAAAVIGGTSLFGGRGRTWNALLGVLVITSIQYGLALQGIATPIQYMITGGVLLATVVIDSVTRKTQKSAGRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K281</accession>
    <name>A0A2M9K281_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_01140</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000001">
        <property type="protein sequence ID" value="PJN13225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN13225">
        <property type="protein sequence ID" value="PJN13225"/>
        <property type="gene ID" value="CG723_01140"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014857731" evidence="1">
        <location>
            <begin position="24"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN13225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="311" mass="33153" checksum="AD08CA283BB51D90" modified="2018-04-25" version="1">MLLIAAVVATALVAGITHRKEPAASRAPGAGTGGRTGVDLLTRVTDYTARFTPSTGYRSPTRNERHTAASGLRLLLAGQADQARERLSEIDLSLDNVTDSSTGRRYAEIADRTEQGRAPRGWGRVYVETGSPARWSVQVPHPVADRNTERLAVGVLRGGQGGVLVIAGAHRKAGTGDAADVAHRRDSVFDAFCDELAERGLPGLQIHGFADDSAPGRDVIASTGRGREGRADGRLLADELRARDFDVCRAWVRSCPLEGHTNVQGAKAAAEHVPFLHVEFANALRTDAPRTGRAVEAMRRVTAAWEKGGTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K2E0</accession>
    <name>A0A2M9K2E0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">3-hydroxyacyl-CoA dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_01480</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000001">
        <property type="protein sequence ID" value="PJN13283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN13283">
        <property type="protein sequence ID" value="PJN13283"/>
        <property type="gene ID" value="CG723_01480"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004181">
        <property type="term" value="F:metallocarboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000834">
        <property type="entry name" value="Peptidase_M14"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00246">
        <property type="entry name" value="Peptidase_M14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00631">
        <property type="entry name" value="Zn_pept"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase_M14" evidence="1">
        <location>
            <begin position="9"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN13283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="416" mass="45642" checksum="164C84A69A13FF0F" modified="2018-04-25" version="1">MSHLTEQRYPNVAELVQSARELASHRPDLCVLRQVGTSRAGRPLHLLSVGHDHRAVLVVAGAHANEPAGGSTLLRLAERALMERELRTDCSWHFLLCADPDGADLHRTPAPRTLLDYHRHFFRPAGPEQPEWSPSVLPPDRLPPETRALTGVIDELRPFLQVSLHGTDLGGSWVQLTRDIPGLAEPFAKSAAELHIPVETGASDAAGWPATGPGVHVMPEPGAEAAFPSLPDDARHSTWHHAHRYGGRTAIVEVPMWASDLVDDPAPHPAPDRALRRLALRLSRDTLLVEEILQSALPRLPEVDGPLMRAARWAVALVPGLAHDWLKPPPPDATMAYVGSIDAFSRRLPLRAAAMLLRVLKEAGDPDTERLEQLVTHWCDAFAERFSARWVPLEHQVEHQSRTTVAAVRHTLAAGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-09-29" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K2I6</accession>
    <name>A0A2M9K2I6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CG723_01795</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CB01635</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000001">
        <property type="protein sequence ID" value="PJN13338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN13338">
        <property type="protein sequence ID" value="PJN13338"/>
        <property type="gene ID" value="CG723_01795"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="41"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="66"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="91"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="124"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="152"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="183"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="214"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="252"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="288"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="322"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="348"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="387"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="422"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="1"/>
            <end position="447"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PJN13338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="463" mass="47116" checksum="9FF2A908E39D60F0" modified="2018-04-25" version="1">MVATMAVVVLLSGIVQGYLTPLLPEVGRSLRIGTVGQNNIYLLFQLACAVLTPLLSRLGDLHGHRRLLRVALAMVAGGSLLIAAWPSAVTLAVGVTLQGALVGFFPLLVGILRSRAPQQNRTGISLLVGVLLISIGVGGLVAGALSEGHAEAGLWTAVPVAVLAVVAGLVLPDSDIPRGGRFHYGAAALLTAGLVALVLVLAQGSTWGWGSARTIGLAVVAVAVLTAWVAVERRSENPLVSVRMLSNPRLAVVSGYTFCAAFGTIGFLGANALFLGSSRSENGYGMDMGPQAIATISLAMVVAGFAGSTLTPRLARRIGDRAVLATGGVLVALGFVGMALFHDSLAQYVTSALVVGLATGLFNSITRTLSSEVVEEHETALAVGLNELALSLGAAIGASVIGGFFTAHAVPGTTRIAESGYLWGWGACACAAVVGTVLALRYRAPQADPATPVPQLAPSGDLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K2K4</accession>
    <name>A0A2M9K2K4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Pyruvate oxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CG723_01905</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CB01635</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the TPP enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000001">
        <property type="protein sequence ID" value="PJN13358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN13358">
        <property type="protein sequence ID" value="PJN13358"/>
        <property type="gene ID" value="CG723_01905"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030976">
        <property type="term" value="F:thiamine pyrophosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012000">
        <property type="entry name" value="Thiamin_PyroP_enz_cen_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012001">
        <property type="entry name" value="Thiamin_PyroP_enz_TPP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011766">
        <property type="entry name" value="TPP_enzyme-bd_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02775">
        <property type="entry name" value="TPP_enzyme_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00205">
        <property type="entry name" value="TPP_enzyme_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02776">
        <property type="entry name" value="TPP_enzyme_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="SSF52467"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0786">Thiamine pyrophosphate</keyword>
    <feature type="domain" description="TPP_enzyme_N" evidence="5">
        <location>
            <begin position="5"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="domain" description="TPP_enzyme_M" evidence="3">
        <location>
            <begin position="192"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="domain" description="TPP_enzyme_C" evidence="4">
        <location>
            <begin position="384"/>
            <end position="530"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU362132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PJN13358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="581" mass="62967" checksum="D13A052FE86ADE09" modified="2018-04-25" version="1">MAKQNVAEQFVDILVRAGVKRMYGVVGDSLNPVVDAIRRNSAIDWIHVRHEETAAFAAGAEAQVTGKLTSCAGSCGPGNLHLINGLYDAHRSMAPVLALASHIPSSEIGLGYFQETHPDRLFQECSHYSEMISNPQQMPRVLQTAIQHAVGQSGVSVVTLPGDIADRPAPEKSVETAIVTSRPTIRPGDAEIDRLVEMIDEAAKVTLFCGSGTAGAHTEVMEFAEKIKSPVGHALRGKEWIQYDNPFDVGMSGLLGYGAAYEATHECDLLILLGTDFPYNAFLPQKDVKIVQVDVRPERLGRRSKLDLAVWGDVRETLRCLTPRVQPKTNRRFLDKMLKKHADTLEGVIKAYTKKVEKHTPIHPEYVASVLDELAADDAVFTVDTGMCNVWAARYISPNGRRRVIGSFSHGSMANALPMAIGAQFVDRGRQVVSMSGDGGFSMLMGDFLTLVQYDLPVKVVLFNNSSLGMVELEMLVAGLPSYGTTNKNPDFAAVARACGAYGVRVEKPKQLAGALKDAFKHKGPALVDIVTDPNALSIPPRISAEMVTGFALSASKIVLDGGVGRMVQMARSNIRNVPRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K309</accession>
    <name>A0A2M9K309_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">GlsB/YeaQ/YmgE family stress response membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CG723_02805</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CB01635</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UPF0410 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000001">
        <property type="protein sequence ID" value="PJN13511.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN13511">
        <property type="protein sequence ID" value="PJN13511"/>
        <property type="gene ID" value="CG723_02805"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007341">
        <property type="entry name" value="Transgly_assoc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33884">
        <property type="entry name" value="PTHR33884"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04226">
        <property type="entry name" value="Transgly_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="27"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="59"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PJN13511.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="88" mass="9229" checksum="66C993DA203CA994" modified="2018-04-25" version="1">MGIISWIILGLVAGVIAKVLLPGRDPGGLIGTTLIGVAGAFVGGWISSRFLDRPIDNQFFDGTTWIAAIGGSLVLLIGYRLLFGNSRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K378</accession>
    <name>A0A2M9K378_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Aldehyde dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_03200</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000001">
        <property type="protein sequence ID" value="PJN13581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN13581">
        <property type="protein sequence ID" value="PJN13581"/>
        <property type="gene ID" value="CG723_03200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016620">
        <property type="term" value="F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="SSF53720"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldedh" evidence="2">
        <location>
            <begin position="63"/>
            <end position="507"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN13581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="531" mass="56950" checksum="762150D85425F4E6" modified="2018-04-25" version="1">MASNPKSRTPGPDAPDLEAPAATTLKAGTSWHDAWQRCLAVAPEAFRDDRVLNLWNGTWQADGRALPASTPVDGSPIAGPPRLDAATAHRAVRASLDQHRAWRHIPLDERRARVGATLDALTQHRELLALLLVWEIGKPWRLAQADVDRAIDGVRWYVDGIEPMVQGRAPLDGPVSNIASWNYPMSVLVHAVLIQALAGNAVIAKTPTDGGVACLTLACALAAREGIPVTLVSGSGGELSEALVRAPEIGCVSFVGGRDTGAAVATAVADLGKRHILEQEGLNTWGIWNYSDWDKLSAVIPKLFDYGKQRCTAYPRFVVQRSLFDDFLAAYLPAVRTLRVGHPLAVTNPQDPYPQLDFGPLVNAAKAKELNDQVAEAIDRGAVPLHRGAPDPARFLPGQDTSAYVHPVTLLSPPPSSPLHHAEPFGPVDTIVLVDTEAELLAAMNASNGALVATLSTDDDATYDRLAPQIRAFKTGRGKPRSRGDRDELFGGFGASWRGAFVGGELLVRAVTQGPEGERLPGNFPDYHLMP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K3B6</accession>
    <name>A0A2M9K3B6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Protocatechuate 3,4-dioxygenase subunit beta</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">pcaH</name>
        <name evidence="5" type="ORF">CG723_03450</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CB01635</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the intradiol ring-cleavage dioxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000001">
        <property type="protein sequence ID" value="PJN13621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN13621">
        <property type="protein sequence ID" value="PJN13621"/>
        <property type="gene ID" value="CG723_03450"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008199">
        <property type="term" value="F:ferric iron binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018578">
        <property type="term" value="F:protocatechuate 3,4-dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019619">
        <property type="term" value="P:3,4-dihydroxybenzoate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000627">
        <property type="entry name" value="Intradiol_dOase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015889">
        <property type="entry name" value="Intradiol_dOase_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024756">
        <property type="entry name" value="PCDO_beta_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012785">
        <property type="entry name" value="Protocat_dOase_b"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00775">
        <property type="entry name" value="Dioxygenase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12391">
        <property type="entry name" value="PCDO_beta_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49482">
        <property type="entry name" value="SSF49482"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02422">
        <property type="entry name" value="protocat_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00083">
        <property type="entry name" value="INTRADIOL_DIOXYGENAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="INTRADIOL_DIOXYGENAS" evidence="4">
        <location>
            <begin position="97"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS00083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PJN13621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="256" mass="28569" checksum="4773CA9474DD7E52" modified="2018-04-25" version="1">MALTQSDIDIEVADLQSAYDKARAGGAPAQHHPPRDYAPYRSSLLRHPKQPLVAVNGGDPETVELSGPVFGATDITDIDQDLTRQHAGEPLGERITVSGRLLDSDGRPVRGQLVEIWQANASGRYAHLRDQHPAPLDPNFTGVGRTLTDDQGRYSFTTVKPGAYPWRNHTNAWRPAHIHFSLFGDAFTQRLVTQMYFPNDPLFRYDPILRSVTDDAARDRLVAAYNHDLSQPEFSLGYEWDIVLDGPSATWIEEGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-09-29" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K3C7</accession>
    <name>A0A2M9K3C7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Beta-ketoadipyl CoA thiolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CG723_03455</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CB01635</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the thiolase-like superfamily. Thiolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000001">
        <property type="protein sequence ID" value="PJN13622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN13622">
        <property type="protein sequence ID" value="PJN13622"/>
        <property type="gene ID" value="CG723_03455"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00751">
        <property type="entry name" value="thiolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002155">
        <property type="entry name" value="Thiolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020615">
        <property type="entry name" value="Thiolase_acyl_enz_int_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020610">
        <property type="entry name" value="Thiolase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020617">
        <property type="entry name" value="Thiolase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020613">
        <property type="entry name" value="Thiolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020616">
        <property type="entry name" value="Thiolase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02803">
        <property type="entry name" value="Thiolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00108">
        <property type="entry name" value="Thiolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000429">
        <property type="entry name" value="Ac-CoA_Ac_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01930">
        <property type="entry name" value="AcCoA-C-Actrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00098">
        <property type="entry name" value="THIOLASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00737">
        <property type="entry name" value="THIOLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00099">
        <property type="entry name" value="THIOLASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Thiolase_N" evidence="5">
        <location>
            <begin position="4"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="domain" description="Thiolase_C" evidence="6">
        <location>
            <begin position="278"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-thioester intermediate" evidence="3">
        <location>
            <position position="90"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="3">
        <location>
            <position position="357"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="3">
        <location>
            <position position="387"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000429-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PJN13622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="400" mass="41425" checksum="C23B44F1E29683A6" modified="2018-04-25" version="1">MKDVYVVDAVRTPVGRYNGSLAAVRPDDLGAHVIRELLARTPELDPALIGDVYFGNANGAGEENRNVGRMAGLLAGLPTSVPGVTVNRLCASGLEAVIQAARAIALGDVSIALAGGVESMTRAPYVLPKSDRPFPAGNTELYSTTLGWRMVNPRMEPQWTVPLGESAELIADKHGITREQQDTYALASHEKASAAQKNGLFDTEIVPVAVPQRKGDPLVVARDECVRESASLEAMATLKPSFRKETGTVTAGNASPLNDGAAALLLVDDEGLKATGREPLARVTASGVAAIDPHYFGLGPVEAVNRALARAGKGFGDLTTLELNEAFAAQVLGCVAEWPEFEPAILNPRGGAIAIGHPLGASGARLAGSVAHQLKAAGAGTGVATLCIGVGQGLALVLER</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K3F9</accession>
    <name>A0A2M9K3F9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Xaa-Pro dipeptidyl-peptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CG723_03630</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000001">
        <property type="protein sequence ID" value="PJN13649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN13649">
        <property type="protein sequence ID" value="PJN13649"/>
        <property type="gene ID" value="CG723_03630"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008239">
        <property type="term" value="F:dipeptidyl-peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005674">
        <property type="entry name" value="CocE/Ser_esterase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000383">
        <property type="entry name" value="Xaa-Pro-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013736">
        <property type="entry name" value="Xaa-Pro_dipept_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02129">
        <property type="entry name" value="Peptidase_S15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08530">
        <property type="entry name" value="PepX_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00939">
        <property type="entry name" value="PepX_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="SSF49785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00976">
        <property type="entry name" value="NonD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014618181" evidence="2">
        <location>
            <begin position="36"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="domain" description="PepX_C" evidence="3">
        <location>
            <begin position="354"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="391"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="623"/>
            <end position="655"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PJN13649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="655" mass="70874" checksum="C927EBDC17A514A9" modified="2018-04-25" version="1">MPIPERRMRPLWRTLATAVTAALLAVLVSPGAAQSATPRESKPVYSYDKAIRESVWVDTRLDGDGDGKTDRVAVDIIRPREPAQQGRKVPVIMDASPYYSCCGRGNESQLKTYDEHGNVVQFPLYYDNYFVPRGYAFVAVDLAGTNRSDGCVDVGGRSDIQSGKAVVDWLNGRGKGYTSRTGTERAKAGWTNGRTGMIGKSYDATIANGVAATGVEGLKTIVPIGGISSWYDYYFQQGAPLYDSGPEWLSDYVESPEARARCAAVQKRLVDEAPRTGDWTGLWDERNYVPDAGKVKASVFVVHGMQDLNVRAKHFGQWWDALAKAGVDRKIWLAQTGHVDPFDSRRSAWVDTLHRWFDHELLGYDNGVDREPMADIERTPDHWTTDRVWPPRTTDSVRLSPAKGSAAGVGKLGLKHGSGTEAFTDDPKLSETDWAAQIDKSTPDKAGFITEPLGKDLRLSGSSKVTVTATPSTTTAHLSAVLVDLGPATIRDYADGGEGITTLTDRTCWGASTAGDSSCFLRTEAKTADVDRTVFSRGWADLGNYASERTGKPLTPGKPYTITLDLAPSDHVVPAGHRLALIVAGTDKDLIDPPSTRPTLTLDLARTSARVPLVGGAHAFESATAGTHTAAPRTSAPERLADPRPFRPVPGGSTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K3Q4</accession>
    <name>A0A2M9K3Q4_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Usp domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_02295</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000001">
        <property type="protein sequence ID" value="PJN13766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN13766">
        <property type="protein sequence ID" value="PJN13766"/>
        <property type="gene ID" value="CG723_02295"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006016">
        <property type="entry name" value="UspA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00582">
        <property type="entry name" value="Usp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Usp" evidence="1">
        <location>
            <begin position="1"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN13766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="166" mass="17985" checksum="672D6326611CE773" modified="2018-04-25" version="1">MVGQVVVGVSDSLGGLAALRAAAEQARRSGRVLVAVLAWEPPEGEGLYARRPDRQWARHWHGEARARLDRAFAEALGGPPRDVDLVRRVVRARPGRALRDAVAGPDDLLVIGVHPRRMWRGRIHRHVVAHAGCPVLTVPAPPLARHELRALRRASAYDFAAAGPAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JEM8</accession>
    <name>A0A2M9JEM8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CG723_45280</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000052">
        <property type="protein sequence ID" value="PJN05350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN05350">
        <property type="protein sequence ID" value="PJN05350"/>
        <property type="gene ID" value="CG723_45280"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PJN05350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="116" mass="13005" checksum="A7BB4EE2FBAB6315" modified="2018-04-25" version="1">MRGRPFSGADLTWAAARIQEMLVRITDVAHTLATWHRTAPRPDLTAARRVVTRGLDIDDSAEILYQDWMLIENQAGNRAGVSAAYETLRTVNQRLEIGMEGETEKVFDTIMSRTAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JEW4</accession>
    <name>A0A2M9JEW4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CG723_45375</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000053">
        <property type="protein sequence ID" value="PJN05343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN05343">
        <property type="protein sequence ID" value="PJN05343"/>
        <property type="gene ID" value="CG723_45375"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PJN05343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="145" mass="15521" checksum="A200418DBB9C3AA8" modified="2018-04-25" version="1">MVLGAGPAVADGTLPRSVPEVDLAYHGQVTMSRGRVETWLIPQNHGPSAVTDATVRLRWSAPVADARWLPPMCVRADARTVLCRTGALPADSRGGQIRVPVRLAGAPSEVTVRIDTMWSGGSADHNPQNSTHHVLALDTGDVYYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JEY8</accession>
    <name>A0A2M9JEY8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_45495</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000055">
        <property type="protein sequence ID" value="PJN05317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN05317">
        <property type="protein sequence ID" value="PJN05317"/>
        <property type="gene ID" value="CG723_45495"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021235">
        <property type="entry name" value="DUF2637"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10935">
        <property type="entry name" value="DUF2637"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="25"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="61"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN05317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="96" mass="10120" checksum="28C8EA175F8D31FB" modified="2018-04-25" version="1" fragment="single">MAGECGRARRGDAVAPPQLTRTHRILIGVVVAGAVVIAGIGFAGSYAAVRSLALQKGFGNFSYVFPIGIDAGICVLLALDLLLTWIRIPFPLLRQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JF78</accession>
    <name>A0A2M9JF78_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CG723_44265</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000046">
        <property type="protein sequence ID" value="PJN05551.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN05551">
        <property type="protein sequence ID" value="PJN05551"/>
        <property type="gene ID" value="CG723_44265"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PJN05551.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="86" mass="9555" checksum="D953A0316536F27F" modified="2018-04-25" version="1">MSLLFIGIDPNTGDKQSPTVWVDQDKQEFVFQGWQPSAELESECAEFEVPGHAKGIPDGEAVVRIPAHMVDMIREACDALERANVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JFC2</accession>
    <name>A0A2M9JFC2_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">FMN dependent NADH:quinone oxidoreductase</fullName>
            <ecNumber evidence="6">1.6.5.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Azo-dye reductase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">FMN-dependent NADH-azo compound oxidoreductase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">FMN-dependent NADH-azoreductase</fullName>
            <ecNumber evidence="6">1.7.1.17</ecNumber>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">azoR</name>
        <name evidence="8" type="ORF">CG723_43660</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CB01635</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Also exhibits azoreductase activity. Catalyzes the reductive cleavage of the azo bond in aromatic azo compounds to the corresponding amines.</text>
    </comment>
    <comment type="function">
        <text evidence="6">Quinone reductase that provides resistance to thiol-specific stress caused by electrophilic quinones.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>2 a quinone + H(+) + NADH = 2 a 1,4-benzosemiquinone + NAD(+)</text>
            <dbReference type="Rhea" id="RHEA:65952"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
            <dbReference type="ChEBI" id="CHEBI:134225"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>anthranilate + N,N-dimethyl-1,4-phenylenediamine + 2 NAD(+) = 2-(4-dimethylaminophenyl)diazenylbenzoate + 2 H(+) + 2 NADH</text>
            <dbReference type="Rhea" id="RHEA:55872"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15783"/>
            <dbReference type="ChEBI" id="CHEBI:16567"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:71579"/>
            <dbReference type="EC" id="1.7.1.17"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="5">
            <dbReference type="Rhea" id="RHEA:55874"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
        <text evidence="6">Binds 1 FMN per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the azoreductase type 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.6.5.-" evidence="6"/>
    <dbReference type="EC" id="1.7.1.17" evidence="6"/>
    <dbReference type="EMBL" id="NNBL01000044">
        <property type="protein sequence ID" value="PJN05601.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN05601">
        <property type="protein sequence ID" value="PJN05601"/>
        <property type="gene ID" value="CG723_43660"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016652">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H, NAD(P) as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016655">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01216">
        <property type="entry name" value="Azoreductase_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003680">
        <property type="entry name" value="Flavodoxin_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023048">
        <property type="entry name" value="NADH:quinone_OxRdtase_FMN_depd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02525">
        <property type="entry name" value="Flavodoxin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52218">
        <property type="entry name" value="SSF52218"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 6" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="2 6" id="KW-0288">FMN</keyword>
    <keyword evidence="4 6" id="KW-0520">NAD</keyword>
    <keyword evidence="3 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flavodoxin_2" evidence="7">
        <location>
            <begin position="3"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="10"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="17"/>
            <end position="19"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="97"/>
            <end position="100"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="136"/>
            <end position="139"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01216"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PJN05601.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="216" mass="23146" checksum="EBEF609DC4FB0570" modified="2018-04-25" version="1">MATLLQIDSSVLPGEVSLSRSVTAAFRKTWEEQHPEGTVIYRDLAANPVPHITADAWSAGYVAPSERTPEQSAAFAARVKLIEELEEADAVLIGAPMYNFSIPSTLKAWLDSVLLLGRTAGETPSAQGTPVVVVASRGGSYAPGTPREGFEFVQNYLEAVLKGTLGLDLDFIVPELTMAPRNAAMADLIPLYEASRKRAFEDATIKAKELAESIAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JFL5</accession>
    <name>A0A2M9JFL5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_43505</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000043">
        <property type="protein sequence ID" value="PJN05679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN05679">
        <property type="protein sequence ID" value="PJN05679"/>
        <property type="gene ID" value="CG723_43505"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="47"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN05679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="69" mass="6966" checksum="7D0C23858732A57F" modified="2018-04-25" version="1">MAHNPQGPAPEGNYDPAGSTQMFRAFVDEPASPSRQQAAPAKSGPGAGLILGIVLAVVIVAGVAWLALK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JFY3</accession>
    <name>A0A2M9JFY3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glyoxalase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_43380</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000043">
        <property type="protein sequence ID" value="PJN05657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN05657">
        <property type="protein sequence ID" value="PJN05657"/>
        <property type="gene ID" value="CG723_43380"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041581">
        <property type="entry name" value="Glyoxalase_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18029">
        <property type="entry name" value="Glyoxalase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VOC" evidence="1">
        <location>
            <begin position="4"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN05657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="128" mass="14116" checksum="4965A8AB214FD609" modified="2018-04-25" version="1">MTSKFTELAIDCADPDTLARFWCSVLGYEVHDREDGLVTIGSPEVPEGKDRLGPVPPALTFARVPEGKAVKNRLHIDVNPTDREQDEEVRRLLDLGARHVDVGQGDVSWVPLADPEGNEFCVLAGRRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JG97</accession>
    <name>A0A2M9JG97_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Segregation/condensation protein A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_42875</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000041">
        <property type="protein sequence ID" value="PJN05777.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN05777">
        <property type="protein sequence ID" value="PJN05777"/>
        <property type="gene ID" value="CG723_42875"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.580">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003768">
        <property type="entry name" value="ScpA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023093">
        <property type="entry name" value="ScpA-like_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33969">
        <property type="entry name" value="PTHR33969"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02616">
        <property type="entry name" value="SMC_ScpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0159">Chromosome partition</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="355"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="60"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="365"/>
            <end position="396"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN05777.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="396" mass="43297" checksum="D4F2EF08CBE3813A" modified="2018-04-25" version="1">MPGYDDDSSTPGRGARRRALGRGPGTTRLSASEPEAAPEPDAVPESELVPQPDAAPEPDAAPEPEPEPDPELVPEPDAVPEPEVQELAGPGPDLEIQEPAGSGPEPELEQPVPDDGRFKVRLANFEGPFDLLLQLISKHKLDVTEVALSKVTDEFMVHIRAMGPEWDLDQTTEFLVVAATLLDLKAARLLPTAEVEDEADLALLEARDLLFARLLQYRAYKKIADIFSERLDEEARRYPRTVGLEPHHAELLPEVVISIGAEGFARLAVKAMQPRPKPQVYVDHIHAPLVSVREQAGLVVARLRELGEASFRVLVEDTDDTLTVVARFLALLELYREKAVSLEQEEALGELLVRWTGGESEGEPTVTDEFDRPPETAGKDGGETKAERGGAEEEQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JGE3</accession>
    <name>A0A2M9JGE3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PadR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_41655</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000037">
        <property type="protein sequence ID" value="PJN05955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN05955">
        <property type="protein sequence ID" value="PJN05955"/>
        <property type="gene ID" value="CG723_41655"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005149">
        <property type="entry name" value="Tscrpt_reg_PadR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03551">
        <property type="entry name" value="PadR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PadR" evidence="1">
        <location>
            <begin position="12"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN05955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="194" mass="21292" checksum="2457185A7E7E42FF" modified="2018-04-25" version="1">MADDLPPTAWAVLGLLSFPGERTGYELKKWADASLRFFYWSPAISQIYAELRRLESLGYVTSLRSGAEDPRAKRTYAITEEGRGALAVWAGSGQGLGAPVLKHPVLLRVWLGHLAAPEHLRDLVTEHVARTKGELKEARDALERADGVEAWAHPQIALRWSERRLAAEVELAEAMLDDLDAVPGQPPGNSPTHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JGE5</accession>
    <name>A0A2M9JGE5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">LLM class flavin-dependent oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_41650</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000037">
        <property type="protein sequence ID" value="PJN05954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN05954">
        <property type="protein sequence ID" value="PJN05954"/>
        <property type="gene ID" value="CG723_41650"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011251">
        <property type="entry name" value="Luciferase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036661">
        <property type="entry name" value="Luciferase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00296">
        <property type="entry name" value="Bac_luciferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51679">
        <property type="entry name" value="SSF51679"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bac_luciferase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN05954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="379" mass="41741" checksum="3B05869551A25D2C" modified="2018-04-25" version="1">MKFSVIFEAQLADPTVEHEHQVIHDCVEQAVLAEEMGFDRIWAVEHHSLKWYAHMSAPEIFLTWVAARTSTIRIGHGVVCMPFNFNHPVRVAERAAMLDLLSGGRLDLGAGRGGTKQETSLCGVDRDRTTQEVEEALRIIGKAWEKDELEHHGELLDIDPHPVLPRPKQEPHPPLFLACSRTETLTQAAELGIGALVMGFAGPESIAGMRRAYDDAIAARTPDRFVSGVVNDHFSVLCPTIVLDDQQTARNIGIRGQRFFAQSIGHWYGGAGVPDEAVVEGADEAADMRRAAEQVVARLHEHQIPVRPTATATFNADHAYGTADDAIAYVERLRDAGADEIMCLVQMGTVPQEACLETLRQWGEKVIPHFRAQEQAASA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JGG0</accession>
    <name>A0A2M9JGG0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MarR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_41725</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000037">
        <property type="protein sequence ID" value="PJN05969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN05969">
        <property type="protein sequence ID" value="PJN05969"/>
        <property type="gene ID" value="CG723_41725"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000835">
        <property type="entry name" value="HTH_MarR-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12802">
        <property type="entry name" value="MarR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00598">
        <property type="entry name" value="HTHMARR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00347">
        <property type="entry name" value="HTH_MARR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50995">
        <property type="entry name" value="HTH_MARR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH marR-type" evidence="1">
        <location>
            <begin position="31"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN05969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="175" mass="18753" checksum="4833932974A3E4CD" modified="2018-04-25" version="1">MTTRNGRAADDTVAAVVQQWQTVHPDIDTGPMEVIGRINRCAALLQQAEDAPLRRAGLTRAEFDLLGALRRTGHELTPGDLSRETFSSGAAVTKRLKQLQERGLVGRRGDTRDRRVSHLSLTDAGRDLVDALLPDQLAYEKTVLSGLGGAGQGQLSVLLGELLGQLEGRPGGPRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JGM9</accession>
    <name>A0A2M9JGM9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NmrA family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_41280</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000036">
        <property type="protein sequence ID" value="PJN06040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN06040">
        <property type="protein sequence ID" value="PJN06040"/>
        <property type="gene ID" value="CG723_41280"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016040">
        <property type="entry name" value="NAD(P)-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13460">
        <property type="entry name" value="NAD_binding_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD(P)-bd_dom" evidence="1">
        <location>
            <begin position="6"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN06040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="279" mass="29159" checksum="D0F3D344F8784F59" modified="2018-04-25" version="1">MIVVTGATGNVGRPLTQALAKAGEQVTAVSRHAAAMPDGVRHVPADLAEPQGLTPALDGAKALFLLLSGDLHAPEARPTDLIDLAAASGVRRVVLLSSQGVATRPLGPSRIAMRAVEDALRESGLHWAVLRPGGFASNALAWAESVRTQGTVAAPFGDVGVPIVDPADIAEVAAACLLDDRHTGGIFELTGPEVITPRQQSEAIAAALGSPVRFHELTREEAKAAMTQFVPPELADDTLDIISAPNPAELRISSDVERVIGRAPRPFNNWVARSIAAFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JGQ3</accession>
    <name>A0A2M9JGQ3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CG723_41375</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000036">
        <property type="protein sequence ID" value="PJN06054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN06054">
        <property type="protein sequence ID" value="PJN06054"/>
        <property type="gene ID" value="CG723_41375"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PJN06054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="217" mass="25686" checksum="4EB4940AAA997948" modified="2018-04-25" version="1">MPLLFIEADNCHEDAATIAAKFDKYMRFYQRTVKYTDGRERPMWHTRWSAPQVQRNVSPAMPPVLLVFHQIGARPARTQMQKVARLTREHWQGRWDSDGAFHTYEQKIPLVATTLELLREQGPHGKIFWRFNRRHLQTLWDAIGTPRLDAALERRREQAQAWHEAHQAEQKRLAAQQAAEHEARRPVCTVCGAKFPDDRWEIVQRYPRPSNEWRPHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JH87</accession>
    <name>A0A2M9JH87_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_40235</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000033">
        <property type="protein sequence ID" value="PJN06249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN06249">
        <property type="protein sequence ID" value="PJN06249"/>
        <property type="gene ID" value="CG723_40235"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN06249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="93" mass="10510" checksum="3DC5EEEBEF20D768" modified="2018-04-25" version="1">MQTLANWDGGPGPWILFFPLIWAAVVIGVVTLLRRTVWRGRRRGGPWRPAADENSPLTVLGRRFAAGEIDEDEYWRRSSVLNEEFGRTKGGAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JHP1</accession>
    <name>A0A2M9JHP1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_39775</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000031">
        <property type="protein sequence ID" value="PJN06398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN06398">
        <property type="protein sequence ID" value="PJN06398"/>
        <property type="gene ID" value="CG723_39775"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN06398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="60" mass="6623" checksum="4DD8336178AD44CF" modified="2018-04-25" version="1">MSRNAKIAAGGVAAGLILLIWLPWWASLLIVLGVPTAAYLALDPSQRRRLRRASRREIGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JHV7</accession>
    <name>A0A2M9JHV7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Sugar ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CG723_39190</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CB01635</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000030">
        <property type="protein sequence ID" value="PJN06433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN06433">
        <property type="protein sequence ID" value="PJN06433"/>
        <property type="gene ID" value="CG723_39190"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="65"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="100"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="130"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="181"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="235"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="65"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PJN06433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="273" mass="29859" checksum="07A0C6FB91B680B7" modified="2018-04-25" version="1">MTRWGARTASHAVIVLITLCFLGPFVWVLLSSVQPGSSPAAELSFSFSLTNFRAVLNWDTVYGPLLNSVVISGSTALLTVVVSGLAAYPLSRYRLRYKRHFMLTLLFSTGLPLSAIMVPVYAMFFRFQLYGSVAAMVLFLTASALPFAIWMMKNFMDGVPISLEEAAWVDGAGWFQSLRRVVAPLMAPGVAVVAIFVFVGQWGNFFVPFVLLDTPEKQPAAVTIYSFFSQYGQVAYGQLAAFSVIYTTPAVLLYVLVNKYLSGSFNMAGSVKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JI34</accession>
    <name>A0A2M9JI34_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">OmpA-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CG723_38280</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000028">
        <property type="protein sequence ID" value="PJN06556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN06556">
        <property type="protein sequence ID" value="PJN06556"/>
        <property type="gene ID" value="CG723_38280"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07185">
        <property type="entry name" value="OmpA_C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006664">
        <property type="entry name" value="OMP_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006665">
        <property type="entry name" value="OmpA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036737">
        <property type="entry name" value="OmpA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00691">
        <property type="entry name" value="OmpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01021">
        <property type="entry name" value="OMPADOMAIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103088">
        <property type="entry name" value="SSF103088"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51123">
        <property type="entry name" value="OMPA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014902903" description="OmpA-like domain-containing protein" evidence="4">
        <location>
            <begin position="29"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="domain" description="OmpA-like" evidence="5">
        <location>
            <begin position="89"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="25"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="184"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="188"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PJN06556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="221" mass="23390" checksum="590852CD21F8888D" modified="2018-04-25" version="1">MPLTRRLAALTTVALIALSASFSGSAYADDPEPSGAPPGSTTTSPPPDVDANSPGLKLADGATLAPAKVLDIKSVVEDLSGDERREDTNQDVKFALQAEVLFQKDSSKLNPDAKSRIQAIADEIKAQHATNVRVFGFTDDLGSYAHGLTLSKKRAEAVHDELAAALGSQDQDVTFAVRGYSEDYPIADNNSEEGRKKNRRVEVTFPKGAATDSADSTGTEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JIT4</accession>
    <name>A0A2M9JIT4_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NADH-quinone oxidoreductase subunit B</fullName>
            <ecNumber evidence="1">7.1.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">NADH dehydrogenase I subunit B</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">NDH-1 subunit B</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">nuoB</name>
        <name evidence="4" type="ORF">CG723_37425</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CB01635</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a quinone + 5 H(+)(in) + NADH = a quinol + 4 H(+)(out) + NAD(+)</text>
            <dbReference type="Rhea" id="RHEA:57888"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="1">Binds 1 [4Fe-4S] cluster.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">NDH-1 is composed of 14 different subunits. Subunits NuoB, C, D, E, F, and G constitute the peripheral sector of the complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the complex I 20 kDa subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.1.1.-" evidence="1"/>
    <dbReference type="EMBL" id="NNBL01000026">
        <property type="protein sequence ID" value="PJN06762.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006133126.1">
        <property type="nucleotide sequence ID" value="NZ_NNBL01000026.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A2M9JIT4"/>
    <dbReference type="EnsemblBacteria" id="PJN06762">
        <property type="protein sequence ID" value="PJN06762"/>
        <property type="gene ID" value="CG723_37425"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01356">
        <property type="entry name" value="NDH1_NuoB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006137">
        <property type="entry name" value="NADH_UbQ_OxRdtase-like_20kDa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006138">
        <property type="entry name" value="NADH_UQ_OxRdtase_20Kd_su"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01058">
        <property type="entry name" value="Oxidored_q6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01957">
        <property type="entry name" value="nuoB_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01150">
        <property type="entry name" value="COMPLEX1_20K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="1" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="1 2" id="KW-0408">Iron</keyword>
    <keyword evidence="1 2" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="1 2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1 2" id="KW-0520">NAD</keyword>
    <keyword evidence="1" id="KW-0874">Quinone</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-1278">Translocase</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Oxidored_q6" evidence="3">
        <location>
            <begin position="37"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="37"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="38"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="103"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="132"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU004464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PJN06762.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="184" mass="20017" checksum="7D887DBD851C5469" modified="2018-04-25" version="1">MGLEEKLPSGFLLTTVEQAAGWVRKSSVFPATFGLACCAIEMMTTGAGRYDLARFGMEVFRGSPRQADLMIVAGRVSQKMAPVLRQVYDQMPNPKWVISMGVCASSGGMFNNYAIVQGVDHVVPVDIYLPGCPPRPEMLMDAILKLHQKIQSSKLGVNAEEAAREAEEAALKALPTIEMKGLLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-05-25" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JJ15</accession>
    <name>A0A2M9JJ15_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DNA-binding response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CG723_36985</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000025">
        <property type="protein sequence ID" value="PJN06875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN06875">
        <property type="protein sequence ID" value="PJN06875"/>
        <property type="gene ID" value="CG723_36985"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00383">
        <property type="entry name" value="trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="3">
        <location>
            <begin position="3"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="domain" description="OmpR/PhoB-type" evidence="4">
        <location>
            <begin position="125"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="2">
        <location>
            <begin position="125"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PJN06875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="225" mass="25094" checksum="F1F5EB02D5E0780D" modified="2018-04-25" version="1">MTRVLLAEDDASISEPLARALRREGYEVEVREDGPTALDAGLQGSIDLVVLDLGLPGMDGLEVARRMRAEGHTVPVLILTARADEVDTVVGLDAGADDYVTKPFRLAELLARVRALLRRGAAEPQQPPATHGVRIDVESHRAWMGDEELQLTAKEFDLLRVLVRDAGRVVTRDQLMREVWDTTWWSSTKTLDMHISWLRKKLGDDAANPRYIATVRGVGFRFEKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JJL5</accession>
    <name>A0A2M9JJL5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF397 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_35570</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000023">
        <property type="protein sequence ID" value="PJN07053.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN07053">
        <property type="protein sequence ID" value="PJN07053"/>
        <property type="gene ID" value="CG723_35570"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007278">
        <property type="entry name" value="DUF397"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04149">
        <property type="entry name" value="DUF397"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF397" evidence="1">
        <location>
            <begin position="17"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN07053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="80" mass="8679" checksum="73F81623E0AB9004" modified="2018-04-25" version="1">MHHVYNGMAATELHGVVWQKSRHSNSQGSCVEFAKLPGGRVAMRNSNFPEGPALVYTPAEIEAMLLGVKDGEFDHLIADG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JK60</accession>
    <name>A0A2M9JK60_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">PadR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_35280</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000022">
        <property type="protein sequence ID" value="PJN07252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN07252">
        <property type="protein sequence ID" value="PJN07252"/>
        <property type="gene ID" value="CG723_35280"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005149">
        <property type="entry name" value="Tscrpt_reg_PadR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03551">
        <property type="entry name" value="PadR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PadR" evidence="2">
        <location>
            <begin position="69"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN07252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="204" mass="21914" checksum="04A79BB041B4D3A5" modified="2018-04-25" version="1">MRSHGYEHEHGHGHGQCGPGHPGRGGFEGRRAAFGPFGPGFGPGPWGGGRGGRGGPRGRARRGDVRASILALLKDRPMHGYEMIQEIAERSGGAWKPSPGSVYPTLQLLEDEGLIASESEGGKKLFALTESGRSAADEGPDAPWEEAGRGVDWDTLNEIRQAGFGLMEAFGQVWKTGSKEQREKALTVINDARKKLYLILADED</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-05-25" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JKE6</accession>
    <name>A0A2M9JKE6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CG723_34365</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">CB01635</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000021">
        <property type="protein sequence ID" value="PJN07338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN07338">
        <property type="protein sequence ID" value="PJN07338"/>
        <property type="gene ID" value="CG723_34365"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04590">
        <property type="entry name" value="CBS_pair_CorC_HlyC_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002550">
        <property type="entry name" value="CNNM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044751">
        <property type="entry name" value="Ion_transp-like_CBS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01595">
        <property type="entry name" value="DUF21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="SSF54631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51846">
        <property type="entry name" value="CNNM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0129">CBS domain</keyword>
    <keyword evidence="5 7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 7 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="56"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="99"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="CNNM transmembrane" evidence="11">
        <location>
            <begin position="1"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="10">
        <location>
            <begin position="218"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="10">
        <location>
            <begin position="282"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="339"/>
            <end position="365"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PJN07338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="365" mass="39086" checksum="FA28912F012C2BB5" modified="2018-04-25" version="1">MSALQLFFALLLVLANGFFVGAEFALVSVRRSQIEPIDNKRARQVLYGLEHLPQMMAAAQFGITVCSLTLGAVAEPTVAHLLEPLFEAMHLPEGTIHPLGYVIALAAVVSLHLVIGEMVPKNLAMAAPEKTALWFSPGLVAFARLCRPVTVALGACARLVLKLFGVEPRDEVEAVFTSVQLGRLVEDSGQAGLLEPEAQERLEDALELGSRPVTDVLLDRSSLVTVGPSVTPGQVIELTGRTGYSRFPVCAEGGAFMGYLHVKDVLDLIDSADHDRAVPQQIWRPMTTLRAELPLDDALTVMRRAATHLAQVADASGRVLGLVALEDVLEMLVGEVRDPAHRDAPAPGARVAEPRAEAPEEALAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JKN5</accession>
    <name>A0A2M9JKN5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Phosphotransferase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_34420</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000021">
        <property type="protein sequence ID" value="PJN07347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN07347">
        <property type="protein sequence ID" value="PJN07347"/>
        <property type="gene ID" value="CG723_34420"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05154">
        <property type="entry name" value="ACAD10_11_N-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041726">
        <property type="entry name" value="ACAD10_11_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="APH" evidence="1">
        <location>
            <begin position="83"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN07347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="364" mass="40719" checksum="3CE8E6DC28E9ED2F" modified="2018-04-25" version="1">MATAPRPRTSTRDPEEVSRRLTSWLAARLPGAEAVNVTVPESNGMSSETLLFDIEHPEPPVRACALRLAADPSAYSIFPDYDMPRQYRTMRLAADRTGLPVPRVLWLEEDPAPLGAPFFVMERVEGRVPPDVMPYTYEGNWLHAATDAERARLQDATVGLIARLHDGVPASEAEFLAASGKGSALRRHVEAQRAYYAWVVDGLPPSPLIESAFDRLAELWPADEGEPVLNWGDARIGNIIYDGFEPAAVLDWEMAALAPREVDLGWTVYLHRFFQDLTESFGQAGLPGFLRREDIERRYAQLTGHAPRDMDFHTLYAALRHAIVMLRVAYRQAYFGEVAVPDDPDTLILHHASLRAMVQGSYWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JKR3</accession>
    <name>A0A2M9JKR3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Xylose isomerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_33665</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000020">
        <property type="protein sequence ID" value="PJN07448.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN07448">
        <property type="protein sequence ID" value="PJN07448"/>
        <property type="gene ID" value="CG723_33665"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036237">
        <property type="entry name" value="Xyl_isomerase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013022">
        <property type="entry name" value="Xyl_isomerase-like_TIM-brl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01261">
        <property type="entry name" value="AP_endonuc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51658">
        <property type="entry name" value="SSF51658"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AP_endonuc_2" evidence="1">
        <location>
            <begin position="30"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN07448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="294" mass="30854" checksum="A728A6FED4A20F7F" modified="2018-04-25" version="1">MTLALNPIQWWATDDGWLDPGLAPQPAELLALVKKAGFDAVMAAVPAGHTVAAYAALLDNAGLRPAPGYFVCRSQGDPADAPAVIEAAAAAARDHAELGLTDIGLGLPMIKGGPRILRPAQGTEPDADRVAALTDLLGRLAEAMRAEGVRPALHPHVGTWIETEAETRAVLDAIPAEQLGFLPDTGHLSWAGADVTGLVADYGSRIPFLHVKDARMAVAEQGRAAGQDYQRTVVDGLWTEPGRGDLDLIGIVAALPDHFAGCLMVEVDRPALTDPYESAVASARWMRSAFALDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JKY0</accession>
    <name>A0A2M9JKY0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_33935</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000020">
        <property type="protein sequence ID" value="PJN07529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN07529">
        <property type="protein sequence ID" value="PJN07529"/>
        <property type="gene ID" value="CG723_33935"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005325">
        <property type="entry name" value="DUF308_memb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03729">
        <property type="entry name" value="DUF308"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="38"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="62"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="94"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="120"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="153"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="177"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN07529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="210" mass="22061" checksum="5A3DE486A9D8B885" modified="2018-04-25" version="1">MTHAPHEPRTPAAEETREERTSPPEGPLGRLAQSAWQVVLLAGIAALILGVLVLVWPGASLFAAGVLFGVYLLVTGVFQLVAAFGTHVTTGLRVMAFISGAVSILLGLFCFRGATQSILLLALWIGIGWLFRGITQTVAAVSDEAMPARGWQIFLGVVSALAGVVLIVSPFESVAVLTLVGGCWLLAVGVVEIVTAFQLRSKAKRIPHGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-09-29" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JLN4</accession>
    <name>A0A2M9JLN4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">RNA helicase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CG723_32520</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000018">
        <property type="protein sequence ID" value="PJN07790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN07790">
        <property type="protein sequence ID" value="PJN07790"/>
        <property type="gene ID" value="CG723_32520"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025696">
        <property type="entry name" value="rRNA_proc-arch_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012961">
        <property type="entry name" value="Ski2_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08148">
        <property type="entry name" value="DSHCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13234">
        <property type="entry name" value="rRNA_proc-arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01142">
        <property type="entry name" value="DSHCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0347">Helicase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="2">
        <location>
            <begin position="44"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="3">
        <location>
            <begin position="283"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="247"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="652"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="250"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PJN07790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="941" mass="104447" checksum="1F632C9AFB688881" modified="2018-04-25" version="1">MTEDLSPAERYAAARKRAAEQATALADFREMYDFGLDPFQIEACQALETGKGVLVAAPTGSGKTIVGEFAVHLALQQGKKCFYTTPIKALSNQKYADLAKRYGADKVGLLTGDNSVNADAPVVVMTTEVLRNMLYAGSQTLLGLGYVVMDEVHYLSDRFRGAVWEEVIIHLPESVTLVSLSATVSNAEEFGDWLDTVRGDTEVIVSEHRPVPLFQHVLAGRRMYDLFEEGEGRKKAVNPDLTRMARMEASRSYNPRDRRKGKMVREADRERERRQRSRIWTPGRPEVIERLDSEGLLPAITFIFSRAACEAAVQQCLYAGLRLNDEEARARVREIVEERTAAIPDEDLHVLGYFEWLEGLERGIAAHHAGMLPTFKEVVEELFVRGLVKAVFATETLALGINMPARSVILEKLVKWNGEQHADITPGEYTQLTGRAGRRGIDVEGHAVVLWQRGFSPEHLAGLAGTRTYPLRSSFKPSYNMAVNLVEQFGRHRSRELLETSFAQFQADKSVVGISRQVQRNEEGLDGYKASMTCHLGDFEEYARLRRELKDRETDLAKQGAAQRRAAAAAALEKLKPGDVIHVPSGKFAGLALVLDPGIPAGRSNGHRGFEQHDGPRPLVLTAERQVKRLASIDFPVPVEALERMRIPKSFNARSPQSRRDLASALRTKAGHIVPDRHRKNRAAAADDREITRLRAELRAHPCHGCDEREDHARWAERYYRLRRDTQQLERRIEGRTNTIARTFDRIVALLTEMDYLRGDEVTQNGKRLARLYGELDLLASECLRDGIWEGLSPAELAACVSALVFEARAADDALAPKLPSGKAKAALGEMVRIWGRLDALEEEFKISQTEGVGQREPDLGFAWAAHQWASGKGLDEVLREADMPAGDFVRWCKQVIDVLGQISAAAPAVSGAGGGDTVAKNARKAVDALRRGVVAYSSVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JM94</accession>
    <name>A0A2M9JM94_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_30280</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000016">
        <property type="protein sequence ID" value="PJN07989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN07989">
        <property type="protein sequence ID" value="PJN07989"/>
        <property type="gene ID" value="CG723_30280"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025326">
        <property type="entry name" value="DUF4232"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14016">
        <property type="entry name" value="DUF4232"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014967903" evidence="2">
        <location>
            <begin position="30"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="22"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="41"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN07989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="293" mass="30164" checksum="6B9B29C778FE211B" modified="2018-04-25" version="1">MRRSASLLPALASTALLLTACEPPPHTQVDDPGKDGVRITSLTLPSASPSPTRTTSVSADSLPVDSGVIAAYEVTNKGTKTLTYSVVFTFMSGDGQAMTNQTATVRDVGPGESVRGTVRAGELPPAAPRVTGAAVLEVTKVPAGEAPAAPGTCPASGIRVSADKGDAAMGLRVVGLHLDNCGTRDYTVDGYPLLELLDDDLNPVHGIQILDGSGDITTGAGPDEQPRPVMLKPGESATAGLVWRNTTEAGTAVNVPHVRVRAKAGADPVTVTPHLDLGTTGRLGVRPWERAER</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JMC9</accession>
    <name>A0A2M9JMC9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ribonuclease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CG723_31370</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CB01635</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000017">
        <property type="protein sequence ID" value="PJN07947.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN07947">
        <property type="protein sequence ID" value="PJN07947"/>
        <property type="gene ID" value="CG723_31370"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017039">
        <property type="entry name" value="Virul_fac_BrkB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30213">
        <property type="entry name" value="PTHR30213"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03631">
        <property type="entry name" value="Virul_fac_BrkB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF035875">
        <property type="entry name" value="RNase_BN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00765">
        <property type="entry name" value="yihY_not_rbn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="12"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="76"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="120"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="165"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="196"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="231"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PJN07947.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="284" mass="30635" checksum="7537FC05BA67DF7F" modified="2018-04-25" version="1">MREFKEDNLTDWAAALTYYGVLAIFPALLALVSILGLLSPSTIDSLIKNLSSMAPGSVRNILTTMLEQLKGGQGKALIALIIGVVLALWSASGYVAAFMRASNIVYDIGEGRPVWKTLPVRLAITAAVVILLALTAVGVVFTGTLAKKMGSVLGLGDTAVTVWNIAKWPVMLILVVLIVMLLYWAAPNVKRRVRRVMPGAALAVVIWLIACALFALYVANLSSYNKTYGTFATPIVALIWLWLTNIAILLGLEFNAELERGRAIEGGLPPGNEPYAEPRDTRKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-05-25" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JMD4</accession>
    <name>A0A2M9JMD4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Amino acid ABC transporter substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_30530</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000016">
        <property type="protein sequence ID" value="PJN08029.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08029">
        <property type="protein sequence ID" value="PJN08029"/>
        <property type="gene ID" value="CG723_30530"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028081">
        <property type="entry name" value="Leu-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13458">
        <property type="entry name" value="Peripla_BP_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peripla_BP_6" evidence="1">
        <location>
            <begin position="18"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN08029.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="370" mass="39365" checksum="C5E14F0B8BB8EEF8" modified="2018-04-25" version="1">MNTPAPAPGAEWTDGSAVRIGALVPLTRPGWVEAGQHLLAGLELAVREVNDGGGIVGRPLELVVRDTAADPQKAAAAVDELARMGVAALAGEYHSVVARAAAARADALGLPYLCSSAVLDALTDHPTEWVARLAPAQSHGWQIYADFLLGAGHSRIAVAAQPSVYWASGARILRDYLAPRGGAVIELDMREFDPAALCDELVESHATALLLLAGHPEPAVSIVKSVRHDQRLAEMLIGAPAGQPEFAEWAKLLGDDGAGIPFLRYLPERLNPLGARVETALRERLGEAPSFVAFEGYDTIAVLADVLRAHGADRSRIAASWPRVAVEGTRGQIKFSRTPGISVWQWAWTSVQVVDRDPAEPDGFRILHTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JME9</accession>
    <name>A0A2M9JME9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Copper oxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_30525</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000016">
        <property type="protein sequence ID" value="PJN08028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08028">
        <property type="protein sequence ID" value="PJN08028"/>
        <property type="gene ID" value="CG723_30525"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011706">
        <property type="entry name" value="Cu-oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045087">
        <property type="entry name" value="Cu-oxidase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709">
        <property type="entry name" value="PTHR11709"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07731">
        <property type="entry name" value="Cu-oxidase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="SSF49503"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Plastocyanin-like" evidence="2">
        <location>
            <begin position="474"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="615"/>
            <end position="637"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN08028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="637" mass="71271" checksum="B67CA7AED79B3975" modified="2018-04-25" version="1">MAGAMGGAAMLPRGAGGQASAADGHGHGSAAGDPSIPHTPKLEKYVDPLPIPRAAISDPSVYPGADFYDITMRPGRWRFHRDLGRAKVWGYWAANPHDPRKPIGMGYLGPTLNVTRDHPTLVKWRNHLPTTHLFQFVIDKIRSGDPQLTPTPPPPYKPMQPFPENVNVWNVVHQHGGFTAPQSDGLPLQSFSPDGIHAESYTTLDPKRVAPNEAICGYTNHDRSCMLWYHDHGMGMTSVNVYAGLAGLYFVHDPADDRLGLPQGEFEVPLILQDRTFHPDGSLAYTMTLQQGEDTPVVNGKAYPFLEVERRRYRLRVLNASNERFWRLRFDVPEDVLPQPVLPFWLIGTDGGLRTPLRMLNFLISPAERYDLIVDFSKLPMGTKVTLTNYNAPVHFPGGDGPEISEIMEFRVTKPLSGGRDRTTPPMKLELPKAAPIEVTAHTRRREWVLYQHQLFGTMTFNAVPFMEPSEDFIKAGSTEIWEYVNPNHDGHPMHVHLVNFQVLNRQPIDAAGYQDQYEKWIDGGRKPKDKPVLANYLTGPPIPPDPDEALSRKDTFKSYPETVTRIVINEFDPPTERIAGLPGSGTELPATYVQHCHILEHEDDDLMRPWTIVGRDDHGEHDQAGGDHDGGHGDDH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-09-29" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JMI7</accession>
    <name>A0A2M9JMI7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CG723_30860</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CB01635</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000016">
        <property type="protein sequence ID" value="PJN08083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08083">
        <property type="protein sequence ID" value="PJN08083"/>
        <property type="gene ID" value="CG723_30860"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="44"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="76"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="105"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="135"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="165"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="212"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="249"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="276"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="301"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="337"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="367"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="1"/>
            <end position="392"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PJN08083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="403" mass="41184" checksum="4A2F30DCE610074A" modified="2018-04-25" version="1">MDGDRRAWRKCSLAGAVFAVCMAGTTLPTPLYGLYQDKFGFSELTVTVVYAVYAFGVIGVLLLAGNASDALGRRPVLLWGLGFAAASAVCFLSATGLGWLYAGRLLSGFAAGLFTGAATVYVIELAPHGGGSRATFVATAANMGGLGCGPLLAGLLAQYAAWPLYLPFAVHLALVAASAAVLLWLPETVAERRPLSTVRPQRPSLPPQVRPVFGPAAIAAFVGFALFGVFTSVSPAFLAESLEVDNHAVSGLVVALAFFASTAGQLAVTRVGMERSLPLGCAGLLAGLALLAGALRWDLLVLVMLSALVGGTGQGLAFRAALGAVAEASPPDHRASVISTLFVVAYAGISVPVIGVGVLTGPIGLEGAGLVFIAVMAVLVSTAGVYLVRRPRRTTPEHARPGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JN82</accession>
    <name>A0A2M9JN82_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Polysaccharide deacetylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_28385</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000014">
        <property type="protein sequence ID" value="PJN08315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08315">
        <property type="protein sequence ID" value="PJN08315"/>
        <property type="gene ID" value="CG723_28385"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002509">
        <property type="entry name" value="NODB_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01522">
        <property type="entry name" value="Polysacc_deac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="SSF88713"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51677">
        <property type="entry name" value="NODB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NodB homology" evidence="1">
        <location>
            <begin position="53"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN08315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="233" mass="26023" checksum="8C656D310052B51D" modified="2018-04-25" version="1">MYHSVDDCRDDPYRVTVSPERLHEQLGRLRRRGLRGVGVAALLEARALGTDRGLVGLTFDDGYCDFVDNALPLLRHYGCGATLFVLPGRLDGVNEWDPLGPRKPLLSERGIRTAASAGIEIGSHGLTHVDLTHVDDRVLRAETEDSRRRLEELTGREVPGFCYPYGTVDRRVADAVRHAGYRYACAISPGDLTGEFALPRVHVGQEDAAWRLELKLRLHRLRRRPSPAPEART</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-06-02" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JNB8</accession>
    <name>A0A2M9JNB8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CG723_28400</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CB01635</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the bacterial sugar transferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000014">
        <property type="protein sequence ID" value="PJN08317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08317">
        <property type="protein sequence ID" value="PJN08317"/>
        <property type="gene ID" value="CG723_28400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003362">
        <property type="entry name" value="Bact_transf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017475">
        <property type="entry name" value="EPS_sugar_tfrase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02397">
        <property type="entry name" value="Bac_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03025">
        <property type="entry name" value="EPS_sugtrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="76"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="108"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="135"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="306"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="domain" description="Bac_transf" evidence="9">
        <location>
            <begin position="304"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PJN08317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="490" mass="52811" checksum="9C566BC529F3D1BA" modified="2018-04-25" version="1">MTAERTVASPAGQPRATAPSTLTASVIPPRAEVGGPRSPAGRRAAERHPSRTPLLAADGTAAVLSTLVIAPVQHHPLLVIALAAGVVAANARAGLYRGDEPRLLLDDWPAIGGRIVVIWCAMAAGLAGFPQLDPLPAATLAAGAALHCLLAGAGRGLVYRRRREAAARRPCPTLLIGPETVARPVAAALLRHPRSGVRPVGILADKGPERPPDHDGPDLPVLGTADELRRAIIRNGVRRALLLDGAAPDRAAWLAVLGEYGCGVWEFDPSADPYPARSGDAARHLAGFRYRPRPPARRRGSVGKRALDLVVSGALLVLTSPVLLVCAVWLRLAEGPGVVFRQERVGKDGKPFTLLKFRTHRPIDAMESATRWSVADEKQMAWFCRFLRRTSLDELLQLWNVFRGDMSLVGPRPERPYFVMQFSQAHPGYAERHRMPTGITGLAQIHGLRGDTSIEDRARFDNAYIDSWSLWQDISILVRTAAALVRSTGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JNK2</accession>
    <name>A0A2M9JNK2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_29155</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000014">
        <property type="protein sequence ID" value="PJN08444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08444">
        <property type="protein sequence ID" value="PJN08444"/>
        <property type="gene ID" value="CG723_29155"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017517">
        <property type="entry name" value="CHP03083_actinobac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034660">
        <property type="entry name" value="DinB/YfiT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010872">
        <property type="entry name" value="MDMPI_C-term_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024344">
        <property type="entry name" value="MDMPI_metal-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036527">
        <property type="entry name" value="SCP2_sterol-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07398">
        <property type="entry name" value="MDMPI_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11716">
        <property type="entry name" value="MDMPI_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109854">
        <property type="entry name" value="SSF109854"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55718">
        <property type="entry name" value="SSF55718"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03083">
        <property type="entry name" value="TIGR03083"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MDMPI_N" evidence="2">
        <location>
            <begin position="17"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="domain" description="MDMPI_C" evidence="1">
        <location>
            <begin position="172"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07398"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF11716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN08444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="274" mass="30392" checksum="A2053DE41E4CB512" modified="2018-04-25" version="1">MSLHPSLESYADAWTHSIEAISELVTPLVEGEWSRATPCPGWSVRDIVSHVIGLDCEMLGDPRPIHTLPRDLYHVQNEHQRYMEMQVDVRRHHTAPEMTSELEYTIIRRSRQLRNESREPGALVRGPLGTEETLEFAMRKRAFDVWVHEQDLRVALGRPGNLDSPGAYVTRDMLFAVLPKVVAKDASAPANSAVVFDVHGPVEFLRTVRVDAEGRGTIDGAPSLGPAVTLSLDWETFVKLACGRVTPDAVSDRVKTEGDLDLAQAILNSLSTTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-09-29" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JNN2</accession>
    <name>A0A2M9JNN2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">3-hydroxyacyl-CoA dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CG723_29275</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CB01635</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 3-hydroxyacyl-CoA dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000014">
        <property type="protein sequence ID" value="PJN08465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08465">
        <property type="protein sequence ID" value="PJN08465"/>
        <property type="gene ID" value="CG723_29275"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070403">
        <property type="term" value="F:NAD+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006180">
        <property type="entry name" value="3-OHacyl-CoA_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006176">
        <property type="entry name" value="3-OHacyl-CoA_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006108">
        <property type="entry name" value="3HC_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041040">
        <property type="entry name" value="3HCDH_RFF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00725">
        <property type="entry name" value="3HCDH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02737">
        <property type="entry name" value="3HCDH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18321">
        <property type="entry name" value="3HCDH_RFF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="SSF48179"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00067">
        <property type="entry name" value="3HCDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="3HCDH_N" evidence="3">
        <location>
            <begin position="13"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="domain" description="3HCDH" evidence="2">
        <location>
            <begin position="193"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="domain" description="3HCDH_RFF" evidence="4">
        <location>
            <begin position="355"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="domain" description="3HCDH" evidence="2">
        <location>
            <begin position="417"/>
            <end position="492"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009463"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF18321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PJN08465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="507" mass="54167" checksum="705E53F73B66526E" modified="2018-04-25" version="1">MTALELGSPERLVGVVGTGTMGQGIAQVALTAGHPVRLYDAVPGRAQEAADAIAARLDRLVDKGRLDAAERDAARARLSAAGSLEEFAGAALVVEAVLERLDVKQQLFTDLEEIVADDCLLATNTSSLSVTAVGGALRLPGRLVGLHFFNPAPLMPLVEVVSGAATDVTAATRAYETARAWGKTPVVCADTPGFIVNRIARPFYAEAFAVYEEQGAQPATIDAVLRECGGFKMGAFELTDLIGQDVNEAVTRSVWEAFFQDVKFRPALAQRRLVEAGMHGRKTGRGWYAYTDGEDRPEPHTAQPAQAPAYVVAEGDLGPAGELLALIREAGIPVREEDEDNGTRLVLPGGGQLALADGQTSVEYRDVIYFDLAFDYRAATRIALATSQEASPQTLREATGLFQAIGKDVSVIGDVPGMIVARTVARLIDLAHDAVAKGVATPEDIDTAMRLGVNYPLGPIEWSRKLGKNWAYSLLDDLHLRDPSGRYAPSLALYRHSYASDKREGSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JNX1</accession>
    <name>A0A2M9JNX1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">GYD domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CG723_27785</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000013">
        <property type="protein sequence ID" value="PJN08572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08572">
        <property type="protein sequence ID" value="PJN08572"/>
        <property type="gene ID" value="CG723_27785"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014845">
        <property type="entry name" value="GYD/TTHA1554"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08734">
        <property type="entry name" value="GYD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PJN08572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="106" mass="11319" checksum="7799772463F7ADC4" modified="2018-04-25" version="1">MPKFLIQATYTPEGTKGLLKEGASGRRAAVDHVVTNLGGQVEAMYFAFGEDDIVLIVDFPDPVSMAAVSLTVKASGALHTRATPLLTLDEIDEAARRQVTFRSPGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JP56</accession>
    <name>A0A2M9JP56_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Anti-sigma factor antagonist</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CG723_26475</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CB01635</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the anti-sigma-factor antagonist family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000012">
        <property type="protein sequence ID" value="PJN08646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08646">
        <property type="protein sequence ID" value="PJN08646"/>
        <property type="gene ID" value="CG723_26475"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043856">
        <property type="term" value="F:anti-sigma factor antagonist activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.750.24">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003658">
        <property type="entry name" value="Anti-sigma_ant"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002645">
        <property type="entry name" value="STAS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036513">
        <property type="entry name" value="STAS_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13466">
        <property type="entry name" value="STAS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52091">
        <property type="entry name" value="SSF52091"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00377">
        <property type="entry name" value="ant_ant_sig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50801">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="STAS" evidence="3">
        <location>
            <begin position="3"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PJN08646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="124" mass="13264" checksum="EB01B27E8E6621E8" modified="2018-04-25" version="1">MTLRVTEGQQGGWAVVRVSGEMDLATSPALRQQVHDAVADGRHSLVLDLSQVLFCDSSGVGVLIAARRLMRSCRGELRLILPAKGAEDGSHVNRVLSALGVRRLFEVYPDVLSAVNDEASPLSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JPF2</accession>
    <name>A0A2M9JPF2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_27085</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000012">
        <property type="protein sequence ID" value="PJN08749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08749">
        <property type="protein sequence ID" value="PJN08749"/>
        <property type="gene ID" value="CG723_27085"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045383">
        <property type="entry name" value="DUF6528"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20138">
        <property type="entry name" value="DUF6528"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014889848" evidence="1">
        <location>
            <begin position="31"/>
            <end position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN08749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="336" mass="35684" checksum="496DC45A0964C417" modified="2018-04-25" version="1">MSALPSRRGVLLGAAGAGLAAVVSPGVAYAAPAGTPAVMVTEQASKRILVLDPQVATWDPAVDPSCVRWQFSPVGDPRYRDLVPVESWVYPAEAKVRVHRGRTYLLTTASFGFAAVVSYPTGRRYWGATLGPGDDLFNPHSIEILPDGNVAVACSTGALVRLYAASLGPHSERFAEVTLKGAHGLHWDARSEVLWALGDDELVAYRVGGSRVRPALTRLSSVGLPVAKPGKSPGGHDLFPVAGRPGRLWVTTSASVFQYDIAGRAFVQDFAGAAEIARPGVKAIGNDPRTGQALSTVPESGLGETWWTTKVSVHRPPAAHTLVNGGIYKARWWLPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JPQ5</accession>
    <name>A0A2M9JPQ5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Na+/galactose cotransporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CG723_27250</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CB01635</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000012">
        <property type="protein sequence ID" value="PJN08777.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08777">
        <property type="protein sequence ID" value="PJN08777"/>
        <property type="gene ID" value="CG723_27250"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1730.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038377">
        <property type="entry name" value="Na/Glc_symporter_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001734">
        <property type="entry name" value="Na/solute_symporter"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00474">
        <property type="entry name" value="SSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00813">
        <property type="entry name" value="sss"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50283">
        <property type="entry name" value="NA_SOLUT_SYMP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="21"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="58"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="91"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="133"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="164"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="194"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="250"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="291"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="344"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="392"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="420"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="449"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="481"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="541"/>
            <end position="558"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU362091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PJN08777.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="560" mass="59842" checksum="A8EB888C07CECA4F" modified="2018-04-25" version="1">MLSPTQTLAAGLRLPTNGLDYAILAIYFVVVLGIGFAARRSVKTSLDFFLSGRSLPAWVTGLAFVAANLGATEILGMAATGAQYGVSVVHWYWIGAIPAMVFLGLVMMPFYYRSKVRSVPEYLLQRFDKSAHLLSSILFAFAAILIAGVNLYALSIVVEALLGWPQWLAIVVAGLFVLAYITIGGLSSAIYNEVLQFFVILAALIPLCIIGLKRVGGWGGMTDSLKSAHGDNFLSAWGGTGIGEANPLGANWLTIILGLGFVLSFGYWTTNFAEVQRALSAKNLSAAQRTPLIAAFPKIFIVFLVMIPGMVAAVLVPKIGMTGSDLTYNDAIPYLMQELLPNGVLGIAVTGLLAAFMAGMAANVSSFNTVFTYDIWAKYVKTGKPDGYYLKFGRLITAVGVLASIGTAFIASSFSNIMGYLQTLFSFFNVPMFVVFIIGMFWKRASMKSGVWGLLAGTTAAMVNYFWIYKQGVIDIPTDQGANFVSAIVGFVAGAVVMVVVTLFTAPKPEAELAGLVYGTAAPGLEELPAEGDDAWYRKPALLGWGAIVLAALCYVPFSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JPU1</accession>
    <name>A0A2M9JPU1_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Peptide chain release factor 1</fullName>
            <shortName evidence="5">RF-1</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">prfA</name>
        <name evidence="7" type="ORF">CG723_25705</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CB01635</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 5">Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="5">Methylated by PrmC. Methylation increases the termination efficiency of RF1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the prokaryotic/mitochondrial release factor family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000011">
        <property type="protein sequence ID" value="PJN08891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08891">
        <property type="protein sequence ID" value="PJN08891"/>
        <property type="gene ID" value="CG723_25705"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016149">
        <property type="term" value="F:translation release factor activity, codon specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00093">
        <property type="entry name" value="Rel_fac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005139">
        <property type="entry name" value="PCRF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000352">
        <property type="entry name" value="Pep_chain_release_fac_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045853">
        <property type="entry name" value="Pep_chain_release_fac_I_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004373">
        <property type="entry name" value="RF-1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03462">
        <property type="entry name" value="PCRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00472">
        <property type="entry name" value="RF-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00937">
        <property type="entry name" value="PCRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75620">
        <property type="entry name" value="SSF75620"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00019">
        <property type="entry name" value="prfA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00745">
        <property type="entry name" value="RF_PROK_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 5" id="KW-0488">Methylation</keyword>
    <keyword evidence="4 5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RF_PROK_I" evidence="6">
        <location>
            <begin position="230"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="modified residue" description="N5-methylglutamine" evidence="5">
        <location>
            <position position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS00745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PJN08891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="358" mass="39241" checksum="C9C68E5AE7C834A0" modified="2018-04-25" version="1">MFEAVEDLIGEHADLEKKLADPSVHADQANARKLNKRYAELTPIVATYRSWKQTGDDIETARELAADDPDFAAEVKDLEKQRAEITEKLRLLLVPRDPNDDKDVILEVKAGAGGDESALFAGDLLRMYLRYAERVGWKTEIIDATESELGGYKDVQVAVKTKGGNGATEPGQGVWARLKYEGGVHRVQRVPSTESQGRIHTSAAGVLVTPEAEDVDVEIHANDLRIDVYRSSGPGGQSVNTTDSAVRITHLPTGVVASCQNEKSQLQNKEQAMRILRSRLLAAAVEKAEAEAADARRSQVRTVDRSEKIRTYNFPENRISDHRVGFKAYNLDQVLDGELDPVIQACVDADSAAKLAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JQ09</accession>
    <name>A0A2M9JQ09_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Glutathione S-transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CG723_26080</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000011">
        <property type="protein sequence ID" value="PJN08954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08954">
        <property type="protein sequence ID" value="PJN08954"/>
        <property type="gene ID" value="CG723_26080"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009297">
        <property type="entry name" value="DUF952"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06108">
        <property type="entry name" value="DUF952"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PJN08954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="112" mass="12427" checksum="13B0CDD34D617E9C" modified="2018-04-25" version="1">MTELLHLTERSLWDAARASGAYEMSTRGRTLAEEGFIHCSLAHQFQKVADFLYGAYDGPDELVVLVIDSARVPAPVRFEAPEPGADEFPHIYGPLPVDAVTEVRNWDGGRVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JQ83</accession>
    <name>A0A2M9JQ83_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">AAA family ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_25575</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000011">
        <property type="protein sequence ID" value="PJN09016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN09016">
        <property type="protein sequence ID" value="PJN09016"/>
        <property type="gene ID" value="CG723_25575"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="628"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="687"/>
            <end position="856"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="6"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="687"/>
            <end position="705"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="741"/>
            <end position="758"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="759"/>
            <end position="773"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="778"/>
            <end position="814"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="815"/>
            <end position="841"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN09016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="856" mass="87535" checksum="15F72069DC5948A0" modified="2018-04-25" version="1">MDPMNRGPKDFGHDPYGGDPYDRADRGHHDDESDTQASRPRPPRDPLTPDFGQPAQGLARTVQLVSGDFLLTVNPVDGSEIEPCPPGERPGRPVKYAPAERADMARAARPPLPAGPPLPRLPLLERQEERERLVRLLARGRSVRLTGPSGSGRTVLLDTVAEDCADVAPDGVVRLSGHRRSSNDLLYDLFAVVYNAPLHRPDRALLLELVHDIGAVVVLDDLEFGGAALDELLEATPECAFLVAATPEVAAPSADSHLEEVFLGGLGRGGGLELLERSVGRVLTEEEANWAGDLWFESEGLPLRFVQAGALLRQRDQLRADPNVFDEFGYFGGPGAPPVDAPFDAEGGHDVPLPSLADGAAPAALLASRLSESARATLRFAVALGGEIPHQAHLPALVGDTHADAALAELVGCALVTPVGGRYRLASGVYDQLATAGYADDTGGHAHTAAQHYAWWAGHPSVGPERVAAEADALLAALTVLVPGTTPAGPDEEGSVAVLLARTAAPAFAAGLSWTVWERCLRSGQEAARLSGDVAEEAYFHHELGILALLGGQLDRARAELEASIALRGALADKRGTIAGRRALALVADRSGGALPGGRTAAGEEVPAARYEESASPPGGVLAAFALPAPPPEPDTLVSRQAGTGPGGKPGGARLAVITGTRRNLVAAGAGALLAAVLGTVVTLGATSNNETPSDSVNVNPSASQGEDGGGIGADQADQGGDDAGSTQRPADPGKDGIPNTSDDPTPSTGPSTGESGKPSDKPSDKPSDKPTDKPTTSKPPSSKPPTSKPPTSKPPTSKPPTSSPPPSSGTPSTSPSPPDTSDSASGPAPSGSSAMSSPADSAPGTPGGPDASSTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JQI0</accession>
    <name>A0A2M9JQI0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CG723_24255</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CB01635</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CsoR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000010">
        <property type="protein sequence ID" value="PJN09047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN09047">
        <property type="protein sequence ID" value="PJN09047"/>
        <property type="gene ID" value="CG723_24255"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003735">
        <property type="entry name" value="Metal_Tscrpt_repr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038390">
        <property type="entry name" value="Metal_Tscrpt_repr_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33677">
        <property type="entry name" value="PTHR33677"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02583">
        <property type="entry name" value="Trns_repr_metal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0186">Copper</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0678">Repressor</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005428"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PJN09047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="116" mass="13000" checksum="0A8743DBD0A998AB" modified="2018-04-25" version="1">MTTEATEIVTDHDGGTVTDHDRGIHGYHHQKAEHLKRLRRIEGQIRGLQRMVDEDVYCIDILTQVSASTKALQSFALQLLEEHLRHCVADAAVKGGEEIDAKVEEATKAIARMLRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JQL1</accession>
    <name>A0A2M9JQL1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">N-acetylglucosamine-6-phosphate deacetylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">nagA</name>
        <name evidence="8" type="ORF">CG723_24925</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CB01635</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
        <text evidence="6">Binds 1 divalent metal cation per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the metallo-dependent hydrolases superfamily. NagA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000010">
        <property type="protein sequence ID" value="PJN09156.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN09156">
        <property type="protein sequence ID" value="PJN09156"/>
        <property type="gene ID" value="CG723_24925"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008448">
        <property type="term" value="F:N-acetylglucosamine-6-phosphate deacetylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006044">
        <property type="term" value="P:N-acetylglucosamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00854">
        <property type="entry name" value="NagA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003764">
        <property type="entry name" value="GlcNAc_6-P_deAcase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11113:SF14">
        <property type="entry name" value="PTHR11113:SF14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01979">
        <property type="entry name" value="Amidohydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038994">
        <property type="entry name" value="NagA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="SSF51338"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00221">
        <property type="entry name" value="nagA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydro-rel" evidence="7">
        <location>
            <begin position="48"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="5">
        <location>
            <begin position="213"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="5">
        <location>
            <begin position="302"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="4">
        <location>
            <position position="268"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="123"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="134"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="189"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="210"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="221"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="245"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR038994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR038994-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR038994-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR038994-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PJN09156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="381" mass="39845" checksum="D3EA01854BDA2A7F" modified="2018-04-25" version="1">MAALNVLSGARVVLPAGVVENGRVIVDGARIAGSAPAGAPSTDLTGHWVVPGFVDIHNHGGGGASFTSGSIDDILKGVRTHRLHGTTTVVASFVTGASDFLTQRAGLLSELAEQGEIAGIHFEGPFISPCRKGAHDETLLRDPDPAEVRKLLDAARGQAKMLTLAPELPGGIDSVRLLAEHGVIAAIGHTDATYEQTVEAIDAGATVATHLYNAMPAIGHRAPGPVSALLEDERITVELINDGTHLHPAALELAFHHVGSGRVAFITDAMDAAGFGDGRYMLGTLEVEVKDSVARLVEGNSIAGSTLTLDRAFKRAATIDKLPVEDIVRAISANPARLLGVDDRVGSLEPGKDADLVVLDEDFDLKGVMRKGRWIVEPQLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JQM8</accession>
    <name>A0A2M9JQM8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_25000</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000010">
        <property type="protein sequence ID" value="PJN09171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN09171">
        <property type="protein sequence ID" value="PJN09171"/>
        <property type="gene ID" value="CG723_25000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014650731" evidence="1">
        <location>
            <begin position="38"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN09171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="97" mass="9773" checksum="34C61326E5D9E871" modified="2018-04-25" version="1">MPFVAPGMTMNMPVRALVTGVLAASAVAGVFAPGAYAADPEPPHQTVIMSNEEAEAAGLVSPGFAPAPCYEPGLYYFGSPAPSAPSGYAPGLCGLRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JQY3</accession>
    <name>A0A2M9JQY3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_25140</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000010">
        <property type="protein sequence ID" value="PJN09197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN09197">
        <property type="protein sequence ID" value="PJN09197"/>
        <property type="gene ID" value="CG723_25140"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="48"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN09197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="82" mass="8390" checksum="103A770F6F763805" modified="2018-04-25" version="1">MRDKTQANSAGPGDRLVKAGGIVFIVGAVATLATMAPLFLGTDPFPPVAYAVCMLMGVGFLISAAGVLRGIAVQRRQARSAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JR26</accession>
    <name>A0A2M9JR26_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CG723_23430</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CB01635</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000009">
        <property type="protein sequence ID" value="PJN09304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN09304">
        <property type="protein sequence ID" value="PJN09304"/>
        <property type="gene ID" value="CG723_23430"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="16"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="75"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="107"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="144"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="200"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="245"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="75"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PJN09304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="281" mass="30188" checksum="640A1D09A3719BEE" modified="2018-04-25" version="1">MSAPAPSSGVPTVRRWATTVLALLIVAVFLFPLYWMLNASLQPAQALLSIPPKWIPTDPTLDGYRAAFDTQGRHLLISLFVACGVVVLTLLLATPLAWALARFRLRYAAPLMFVLLIVQMLPGIVKANSLFTLYSHLGLLNNTIGLMLAQSTLAVPFAAVLLRSQLRDIPAEIIEAAALDGAGTWRTFLRIVVPLSRNGLITAGLFAFLFSWADFLFAISLTSRDAVTPVTVGIYRFIGANATDWNALMASAVLASVPAAILLIVAQRYIAVGITGGSVKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JRE4</accession>
    <name>A0A2M9JRE4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_22045</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000008">
        <property type="protein sequence ID" value="PJN09460.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN09460">
        <property type="protein sequence ID" value="PJN09460"/>
        <property type="gene ID" value="CG723_22045"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="51"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN09460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="80" mass="8981" checksum="71C300E7439F008C" modified="2018-04-25" version="1">MADVAQVMHRWGLRSAQLQLAAMGSVGLCTVFWMRAASFDQDERGNAERRALFVGLWAPTLWLMAQSLRDLDQAVHAPPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JRQ1</accession>
    <name>A0A2M9JRQ1_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SnoaL-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_22760</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000008">
        <property type="protein sequence ID" value="PJN09560.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN09560">
        <property type="protein sequence ID" value="PJN09560"/>
        <property type="gene ID" value="CG723_22760"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037401">
        <property type="entry name" value="SnoaL-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12680">
        <property type="entry name" value="SnoaL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="SSF54427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SnoaL-like" evidence="1">
        <location>
            <begin position="10"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12680"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN09560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="134" mass="14786" checksum="33016BA4CF19CBDF" modified="2018-04-25" version="1">MTAESPAQTVQRLFPLLAEGKSAEAAALFADSVSFSIPHPPGIPWVPDVDSAEGMRRFFELLQTHVQAKEFALGQIIAEGDDVVLVGRMVSEVKKTGRDIDTAFALHTTVRDGRITRYHLYEDSYAVAKAYFDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JRZ1</accession>
    <name>A0A2M9JRZ1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_22060</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000008">
        <property type="protein sequence ID" value="PJN09624.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN09624">
        <property type="protein sequence ID" value="PJN09624"/>
        <property type="gene ID" value="CG723_22060"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046134">
        <property type="entry name" value="DUF6131"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19626">
        <property type="entry name" value="DUF6131"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN09624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="51" mass="5511" checksum="12192865B835E1B8" modified="2018-04-25" version="1">MIILGVILLVVGFLTGLSILWTIGIIVLVIGAILWILGAMGHAVAGRRHYW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-09-29" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JRZ9</accession>
    <name>A0A2M9JRZ9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CG723_22550</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CB01635</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000008">
        <property type="protein sequence ID" value="PJN09633.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN09633">
        <property type="protein sequence ID" value="PJN09633"/>
        <property type="gene ID" value="CG723_22550"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="24"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="56"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="84"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="118"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="152"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="224"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="257"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="290"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="314"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="344"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="378"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="1"/>
            <end position="402"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PJN09633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="428" mass="45576" checksum="C27EB7583A923E31" modified="2018-04-25" version="1">MFVVNYMDRVNIGFAKDELSADTGLSAAAFGVGAGIFFIAYAIFEVPSNILMERFGARIWLTRIMISWGVVATAMAFVNSAEMFYALRFLLGVAEAGFFPAVIYYFSRWLPDSHRGRATSIFLMGSGTATVIVGPISGALMEMHGLLGHAGWQWMFFIEGLFSVALGFVVYRFLDNSIESADWLTDEEKQGLVATIDAEQAARESKRGTAKVSRWKLLADPQMLLFLWIYFAINVALYAVTFWLPSIVDDVGDLSEFQVGLLTSVPWLFAIAAVWVSGRISDRMGKRRPLLITLLLIGSLGTLLAVYVSPWLGLGALCIAAVGFKPASPIFWTIPQNYLDARAAAPGIALINSIGNLGGFVAPTAFGILETTTGSTKGGLVGLTVVGILAALSVLLVRGGGRNDSVGGGAVDSAAGASAAADPKPASA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-05-25" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JS22</accession>
    <name>A0A2M9JS22_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 9">D-3-phosphoglycerate dehydrogenase</fullName>
            <ecNumber evidence="9">1.1.1.95</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CG723_20785</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CB01635</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the reversible oxidation of 3-phospho-D-glycerate to 3-phosphonooxypyruvate, the first step of the phosphorylated L-serine biosynthesis pathway. Also catalyzes the reversible oxidation of 2-hydroxyglutarate to 2-oxoglutarate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 9">
            <text>(2R)-3-phosphoglycerate + NAD(+) = 3-phosphooxypyruvate + H(+) + NADH</text>
            <dbReference type="Rhea" id="RHEA:12641"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:18110"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:58272"/>
            <dbReference type="EC" id="1.1.1.95"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(R)-2-hydroxyglutarate + NAD(+) = 2-oxoglutarate + H(+) + NADH</text>
            <dbReference type="Rhea" id="RHEA:49612"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15801"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.399"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4 9">Amino-acid biosynthesis; L-serine biosynthesis; L-serine from 3-phospho-D-glycerate: step 1/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5 9">Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.95" evidence="9"/>
    <dbReference type="EMBL" id="NNBL01000007">
        <property type="protein sequence ID" value="PJN09652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN09652">
        <property type="protein sequence ID" value="PJN09652"/>
        <property type="gene ID" value="CG723_20785"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00135">
        <property type="reaction ID" value="UER00196"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004617">
        <property type="term" value="F:phosphoglycerate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006564">
        <property type="term" value="P:L-serine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002912">
        <property type="entry name" value="ACT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029009">
        <property type="entry name" value="ASB_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006139">
        <property type="entry name" value="D-isomer_2_OHA_DH_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029753">
        <property type="entry name" value="D-isomer_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029752">
        <property type="entry name" value="D-isomer_DH_CS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006140">
        <property type="entry name" value="D-isomer_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006236">
        <property type="entry name" value="PGDH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045626">
        <property type="entry name" value="PGDH_ASB_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00389">
        <property type="entry name" value="2-Hacid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02826">
        <property type="entry name" value="2-Hacid_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01842">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19304">
        <property type="entry name" value="PGDH_inter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143548">
        <property type="entry name" value="SSF143548"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="SSF55021"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01327">
        <property type="entry name" value="PGDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51671">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00065">
        <property type="entry name" value="D_2_HYDROXYACID_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00670">
        <property type="entry name" value="D_2_HYDROXYACID_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00671">
        <property type="entry name" value="D_2_HYDROXYACID_DH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="9" id="KW-0520">NAD</keyword>
    <keyword evidence="7 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 9" id="KW-0718">Serine biosynthesis</keyword>
    <feature type="domain" description="ACT" evidence="10">
        <location>
            <begin position="467"/>
            <end position="541"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00003800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005216"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00005854"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00021582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU363003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PJN09652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="541" mass="56135" checksum="E91C8557438221AF" modified="2018-04-25" version="1">MGLVRTHVSTAATGKPVVLIAEELSPATVDALGPDFEIRQCNGGDRAELLPAIADVDAILIRSATKVDAEAIAAAKKLKVVARAGVGLDNVDVSAATKAGVMVVNAPTSNIVTAAELACGLLIATARNIPQGSQALKAGEWKRSKYTGVELAEKTLGVVGLGRIGALVAQRMSAFGMKVVAYDPYVQPARAAQMGVKVLTLDELLEVSDFITVHLPKTPETVGLIGDDALRKVKPTVRIVNAARGGIVDEAALYSALKEGRVAGAGLDVYAKEPCTDSPLFEFDQVVATPHLGASTDEAQEKAGIAVARSVRLALAGELVPDAVNVQGGVIAEDVKPGLPLAEKLGRIFTALAGEVAARLDVEVYGEITQHDVKVLELSALKGVFEDVVDETVSYVNAPLFAQERGVEVRLTTSSESPDHRNVVTVRGTLTGGEEISVSGTLAGPKHLQKIVAVGEYDVDLALADHMVVLRYEDRPGVVGTVGRVLGEAGINIAGMQVARADLGGEALAVLTVDDTVPAGVLSELGDEIGATSARSVNLTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JS76</accession>
    <name>A0A2M9JS76_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Signal recognition particle receptor FtsY</fullName>
            <shortName evidence="5">SRP receptor</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">ftsY</name>
        <name evidence="8" type="ORF">CG723_21185</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CB01635</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC).</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Peripheral membrane protein</topology>
            <orientation evidence="5">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the GTP-binding SRP family. FtsY subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000007">
        <property type="protein sequence ID" value="PJN09719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN09719">
        <property type="protein sequence ID" value="PJN09719"/>
        <property type="gene ID" value="CG723_21185"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031226">
        <property type="term" value="C:intrinsic component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006614">
        <property type="term" value="P:SRP-dependent cotranslational protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00920">
        <property type="entry name" value="FtsY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013822">
        <property type="entry name" value="Signal_recog_particl_SRP54_hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004390">
        <property type="entry name" value="SR_rcpt_FtsY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036225">
        <property type="entry name" value="SRP/SRP_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000897">
        <property type="entry name" value="SRP54_GTPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042101">
        <property type="entry name" value="SRP54_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43134:SF7">
        <property type="entry name" value="PTHR43134:SF7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00448">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02881">
        <property type="entry name" value="SRP54_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00962">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00963">
        <property type="entry name" value="SRP54_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47364">
        <property type="entry name" value="SSF47364"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00064">
        <property type="entry name" value="ftsY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00300">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4 5" id="KW-0675">Receptor</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SRP54" evidence="7">
        <location>
            <begin position="376"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="26"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="29"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="51"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="211"/>
            <end position="218"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="293"/>
            <end position="297"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="355"/>
            <end position="358"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS00300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PJN09719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="404" mass="42981" checksum="35FE1990B56D53F0" modified="2018-04-25" version="1">MEIVILAVVIAVVVIGALGGLVVGSRRRKQLPPPPPSVPDITAPPAEPHVGEEAETPRDEPRRTIEEVDLPLVEPEPSAPIAVEEPPAPAAPEIEVPEPTAGRLVRLRSRLSRSQNALGKGLLTLLSREHLDEDTWEEIEDTLLTADVGVQPTQELVDRLRERVKVLGTRTPDELRALLREELVQLLVPEFDRSVKTDSNLDTPGIVMVVGVNGTGKTTTTGKLARVLVADGRNVVLGAADTFRAAAADQLQTWGERVGARTVRGPEGGDPASIAFDAVKEGIEEGADVVLIDTAGRLHTKTGLMDELGKVKRVVEKHAPLDEILLVLDATTGQNGLVQARVFAEVVDITGIVLTKLDGTAKGGIVIAVQRELGVPVKLIGLGEGPDDLAPFEPEAFVDALIGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JSE8</accession>
    <name>A0A2M9JSE8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Acyl-CoA dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CG723_21545</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CB01635</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000007">
        <property type="protein sequence ID" value="PJN09783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN09783">
        <property type="protein sequence ID" value="PJN09783"/>
        <property type="gene ID" value="CG723_21545"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016627">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="SSF47203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="SSF56645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0274">FAD</keyword>
    <keyword evidence="3 5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA_dh_N" evidence="9">
        <location>
            <begin position="62"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_M" evidence="8">
        <location>
            <begin position="172"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_1" evidence="7">
        <location>
            <begin position="280"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PJN09783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="646" mass="70263" checksum="46BA47CF08AD5FD5" modified="2018-04-25" version="1">MAAPTSQQPSVSEREARQVAEAAREQGWRKPSFAKELFLGRFRLDLIHPHPQPAGEDVRRGEEFLAKLRDFCETRIDPARIEREAQIPDEVINGLKELGALGMKIDTKYGGLGLTQVYYNKALALVGTVNPAIGALLSAHQSIGVPQPLKIFGTQEQKDTFLPRCASTDITAFLLTEPDVGSDPARLATTAVPDGDSYILDGVKLWTTNGVVADLLVVMARVPKAEGRKGGITAFVVEADSEGITVENRNAFMGLRGLENGVTRFHQVRVPAANRIGPEGAGLKIALTTLNTGRLSLPAMCVGAGKWCLKIAREWSGAREQWGKPVAFHEAVGQKISFIAATTFALEAVVDLSSQMADEDRNDIRIEAALAKLFGSEMGCLMADELVQIRGGRGFETAESLAARGERAVPAEQLLRDLRINRIFEGSTEIMHLLIAREAVDAHLSVAGDLIDPDKSLSDKAKAGAKAGGFYARWLPKLVAGPGQLPNSYSEFHPAGHADLSGHLRFAERSARKLARSTFYAMSRWQGKMETKQGFLGRIVDIGAELFAMSAACVRAEHLRGAGEHGREAYQLADVFCSQSRVRVDELFGRLWHNTDELDRKVTKGVLGGSYTWLEEGVIDPSGDGAWIADATPGPSKRENVRRPIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JSG4</accession>
    <name>A0A2M9JSG4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Type VII secretion-associated serine protease mycosin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">mycP</name>
        <name evidence="16" type="ORF">CG723_21725</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">CB01635</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the peptidase S8 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000007">
        <property type="protein sequence ID" value="PJN09816.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN09816">
        <property type="protein sequence ID" value="PJN09816"/>
        <property type="gene ID" value="CG723_21725"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000209">
        <property type="entry name" value="Peptidase_S8/S53_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023827">
        <property type="entry name" value="Peptidase_S8_Asp-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022398">
        <property type="entry name" value="Peptidase_S8_His-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023828">
        <property type="entry name" value="Peptidase_S8_Ser-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015500">
        <property type="entry name" value="Peptidase_S8_subtilisin-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023834">
        <property type="entry name" value="T7SS_pept_S8A_mycosin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00082">
        <property type="entry name" value="Peptidase_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00723">
        <property type="entry name" value="SUBTILISIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="SSF52743"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03921">
        <property type="entry name" value="T7SS_mycosin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00136">
        <property type="entry name" value="SUBTILASE_ASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00137">
        <property type="entry name" value="SUBTILASE_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00138">
        <property type="entry name" value="SUBTILASE_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 11 16" id="KW-0645">Protease</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 11" id="KW-0720">Serine protease</keyword>
    <keyword evidence="14" id="KW-0732">Signal</keyword>
    <keyword evidence="6 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="14">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014708931" evidence="14">
        <location>
            <begin position="23"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="371"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_S8" evidence="15">
        <location>
            <begin position="57"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="85"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="88"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="PJN09816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="407" mass="41794" checksum="11C2DB12F7A85BE5" modified="2018-04-25" version="1">MAAALTVTVTTTALLPAGPAAAEGEQCTFGPKNPKYEGRPWSLQRVLLDDLWSETKGKGVKVAVIDTGVDVKNPQLTHAVDTSKGKNLLPKNLKDDNGSKIERGKENGTTDTVGHGTRVAGIIAARPAKGTGFVGLAPEATIIPIQQNDAEGHGTAKTLADAIVYAKSVGAQVINISQDTANAVKPDQVLQDAVDSALAAKIVVVASAGNDGLDGKVKETYPASFPGVLAVAASDRNNERASFSQSGEFVGVAAPGVDMVSTVPGAGHCSDNGTSFSAPYVAGVAALVKAKHPDWTAAEVVAQIEQTAERSTSGHDRLVGWGVVDPVRAVTEDPDHPIESPSPNEGVTRAEAPTAAKLHFGETAEQRDTRLATYTVVGTAVLVAGLGGAAVAVRDARRRGRRTAGGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JSM4</accession>
    <name>A0A2M9JSM4_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 10">Purine nucleoside phosphorylase</fullName>
            <ecNumber evidence="6 10">2.4.2.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Inosine-guanosine phosphorylase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CG723_19185</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">CB01635</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta-(deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate. Cleaves guanosine, inosine, 2'-deoxyguanosine and 2'-deoxyinosine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>a purine 2'-deoxy-D-ribonucleoside + phosphate = 2-deoxy-alpha-D-ribose 1-phosphate + a purine nucleobase</text>
            <dbReference type="Rhea" id="RHEA:36431"/>
            <dbReference type="ChEBI" id="CHEBI:26386"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57259"/>
            <dbReference type="ChEBI" id="CHEBI:142361"/>
            <dbReference type="EC" id="2.4.2.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 10">Purine metabolism; purine nucleoside salvage.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homotrimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 10">Belongs to the PNP/MTAP phosphorylase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.1" evidence="6 10"/>
    <dbReference type="EMBL" id="NNBL01000006">
        <property type="protein sequence ID" value="PJN09870.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN09870">
        <property type="protein sequence ID" value="PJN09870"/>
        <property type="gene ID" value="CG723_19185"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00606"/>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004731">
        <property type="term" value="F:purine-nucleoside phosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009116">
        <property type="term" value="P:nucleoside metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09009">
        <property type="entry name" value="PNP-EcPNPII_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1580">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000845">
        <property type="entry name" value="Nucleoside_phosphorylase_d"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035994">
        <property type="entry name" value="Nucleoside_phosphorylase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011269">
        <property type="entry name" value="PUNP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011268">
        <property type="entry name" value="Purine_phosphorylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018099">
        <property type="entry name" value="Purine_phosphorylase-2_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11904">
        <property type="entry name" value="PTHR11904"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01048">
        <property type="entry name" value="PNP_UDP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000477">
        <property type="entry name" value="PurNPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53167">
        <property type="entry name" value="SSF53167"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01697">
        <property type="entry name" value="PNPH-PUNA-XAPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01698">
        <property type="entry name" value="PUNP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01240">
        <property type="entry name" value="PNP_MTAP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PNP_UDP_1" evidence="12">
        <location>
            <begin position="40"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="region of interest" description="Phosphate binding" evidence="11">
        <location>
            <begin position="98"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="46"/>
        </location>
        <ligand>
            <name>phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="78"/>
        </location>
        <ligand>
            <name>phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="130"/>
        </location>
        <ligand>
            <name>phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="199"/>
        </location>
        <ligand>
            <name>a purine D-ribonucleoside</name>
            <dbReference type="ChEBI" id="CHEBI:142355"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="218"/>
        </location>
        <ligand>
            <name>phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="241"/>
        </location>
        <ligand>
            <name>a purine D-ribonucleoside</name>
            <dbReference type="ChEBI" id="CHEBI:142355"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006751"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00011886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00013834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR000477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR000477-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PJN09870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="278" mass="29188" checksum="51EBB1AD9F5C939C" modified="2018-04-25" version="1">MNASVTPDNIQGATRFDPRVAADAAASRLRELTGADTHDVALVMGSGWAPAVDALGTPEAEFPVTELPGFPPPAVEGHGGKIRSYKIGDKRALVFLGRTHYYEGRGVASVAHGVRTAVAAGCKTIVLTNGCGGLREGMRPGQPVLISDHLNLTATSPIVGANFVDLTDLYSPRLRTLCKEIDPSLEEGVYAQFPGPHYETPAEIRMARTIGADLVGMSTVLEAIAAREAGAEVLGISLVTNLAAGMTGEPLNHEEVLQAGRDSATRMGELLGKVLDRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JSQ5</accession>
    <name>A0A2M9JSQ5_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">VanZ domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CG723_19260</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000006">
        <property type="protein sequence ID" value="PJN09883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN09883">
        <property type="protein sequence ID" value="PJN09883"/>
        <property type="gene ID" value="CG723_19260"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006976">
        <property type="entry name" value="VanZ-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04892">
        <property type="entry name" value="VanZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="domain" description="VanZ" evidence="3">
        <location>
            <begin position="25"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="158"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PJN09883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="180" mass="18876" checksum="4C2051D34815F4E8" modified="2018-04-25" version="1">MQRHRPGGSKAAIRFRTAGIVLLAAHLLLVCWITLRPLDVPWVSAANLHPFAGIRADLALGPAEAVRRIGKELVLLAPLGVLLPIAGGRLVVSPLGSLVRTVAAGALLSLGIELLQTGVPGQVVDIDSLFLNTLGVALAHAAVVPTLRGRLRRRAEVPALPREEPSQGRTPTISRVGIAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JT27</accession>
    <name>A0A2M9JT27_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Chaperonin GroEL</fullName>
            <ecNumber evidence="9">5.6.1.7</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">60 kDa chaperonin</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Chaperonin-60</fullName>
            <shortName evidence="9">Cpn60</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9 12" type="primary">groL</name>
        <name evidence="9" type="synonym">groEL</name>
        <name evidence="12" type="ORF">CG723_20035</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">CB01635</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9 11">Together with its co-chaperonin GroES, plays an essential role in assisting protein folding. The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9 11">Forms a cylinder of 14 subunits composed of two heptameric rings stacked back-to-back. Interacts with the co-chaperonin GroES.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell surface</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="8">Secreted</location>
            <location evidence="8">Capsule</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Secreted</location>
            <location evidence="1">Cell wall</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9 10">Belongs to the chaperonin (HSP60) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.6.1.7" evidence="9"/>
    <dbReference type="EMBL" id="NNBL01000006">
        <property type="protein sequence ID" value="PJN10013.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN10013">
        <property type="protein sequence ID" value="PJN10013"/>
        <property type="gene ID" value="CG723_20035"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042603">
        <property type="term" value="C:capsule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042026">
        <property type="term" value="P:protein refolding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03344">
        <property type="entry name" value="GroEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.560.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.7.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00600">
        <property type="entry name" value="CH60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018370">
        <property type="entry name" value="Chaperonin_Cpn60_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001844">
        <property type="entry name" value="Cpn60/GroEL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002423">
        <property type="entry name" value="Cpn60/GroEL/TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027409">
        <property type="entry name" value="GroEL-like_apical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027413">
        <property type="entry name" value="GROEL-like_equatorial_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027410">
        <property type="entry name" value="TCP-1-like_intermed_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00118">
        <property type="entry name" value="Cpn60_TCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00298">
        <property type="entry name" value="CHAPERONIN60"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48592">
        <property type="entry name" value="SSF48592"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52029">
        <property type="entry name" value="SSF52029"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54849">
        <property type="entry name" value="SSF54849"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02348">
        <property type="entry name" value="GroEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00296">
        <property type="entry name" value="CHAPERONINS_CPN60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 9" id="KW-0143">Chaperone</keyword>
    <keyword evidence="9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 9" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="29"/>
            <end position="32"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="86"/>
            <end position="90"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="415"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="479"/>
            <end position="481"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="495"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006607"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00025702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000419"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PJN10013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="541" mass="56827" checksum="60B11F5A6B7B980B" modified="2018-04-25" version="1">MAKILKFDEDARRALERGVNKLADTVKVTIGPKGRNVVIDKKFGAPTITNDGVTIAREVELDDPYENLGAQLVKEVATKTNDIAGDGTTTATVLAQALVKEGLRNVAAGASPAALKKGIDAAVKAVSEELLATARPIEDKADIAAVAGLSAQDSQVGELIAEAMDKVGKDGVITVEESNTFGLELDFTEGMAFDKGYLSPYFVTDQERMEAVLEDPYILINQGKISSIQDMLPLLEKVIQAGGSKPLLIIAEDVEGEALSTLVVNKIRGTFNAVAVKAPGFGDRRKAMLGDMATLTGATVIAEEVGLKLDQAGLDVLGTARRVTITKDDTTIVDGGGVKGDVEGRVNQIKAEIENTDSDWDREKLQERLAKLAGGVCVIKVGAATEVELKEKKHRLEDAISATRAAVEEGIVSGGGSALVHAVKILEGNLDKTGDEATGVAVVRRAAVEPLRWIAENAGLEGYVITSKVAELDKGQGFNAATGEYGDLVKAGVIDPVKVTRSALENAASIASLLLTTETLVVEKPAEEESEAGGHGHGHSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JUK9</accession>
    <name>A0A2M9JUK9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_15120</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000004">
        <property type="protein sequence ID" value="PJN10553.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN10553">
        <property type="protein sequence ID" value="PJN10553"/>
        <property type="gene ID" value="CG723_15120"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000674">
        <property type="entry name" value="Ald_Oxase/Xan_DH_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036856">
        <property type="entry name" value="Ald_Oxase/Xan_DH_a/b_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016208">
        <property type="entry name" value="Ald_Oxase/xanthine_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008274">
        <property type="entry name" value="AldOxase/xan_DH_Mopterin-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037165">
        <property type="entry name" value="AldOxase/xan_DH_Mopterin-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11908">
        <property type="entry name" value="PTHR11908"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01315">
        <property type="entry name" value="Ald_Xan_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02738">
        <property type="entry name" value="Ald_Xan_dh_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01008">
        <property type="entry name" value="Ald_Xan_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54665">
        <property type="entry name" value="SSF54665"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56003">
        <property type="entry name" value="SSF56003"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ald_Xan_dh_C" evidence="2">
        <location>
            <begin position="36"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="431"/>
            <end position="450"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN10553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="775" mass="81110" checksum="C862902881709310" modified="2018-04-25" version="1">MSDEAAATAPAAPVAEPLPHGLGASLPPAEARAKTEGTFPYAADLWAEGLLWAAVLRSPHPHARILSIDTTHAREMPGVRAVITHEDVPGAPLPGHRAADRPVFASDVVRHHGEAIAAVAADHPDTARMAAAAVIVEYEVLEPVTDPEQSFAAEPLHPDGNLIRHIPLRHGDQDAVGEIVVEGQYRIGRQDPAPIGAEAGLAVPRPDGGVELYIASTDPHGDRDLAAARYGLEPERVKVVVTGVPGATGDREDQSFQLPLGLLALRTGCPVKLTATREESFLGHTHRHPTLLRYRHHADAEGKLVKVEAQILLDAGAYADTSSEALAAAVSFACGPYVVPHAFIEGWAVRTNNPPSGHVRGEGALQVCAAYEAQMDKLAKKLGIDPAELRLRNAMATGDVLPTGQTVTCPAPVAELLVAVRDFPLPELPRDTPEDEWLLPGGPEGAGEPGAVRRGVGYGIGMVHMLGAEGTDEVSTATVKVHDGVATVICAAVETGQGFTTLARQIVQDTLGIDEVQVAPVDTDQPPAGPGCRGRHTWVSGGAVERAAKMVRTQLLQPLAHKFGMSTELLQIADGKITSYDGVLSTTVTEAMDGKELWATAQCRPHPTEPLDAEGQGDAFVGLAFCAIRAVVDVDIELGSVRVVELAVAQDVGRVLNPAQLTARIEAGVTQGVGAALTENLRTPRGLVRHPDFTGYALPTALDAPDIRIVKLVEERDVVAPFGAKAASAVPVVASPAAVASAVRAATGRPVNRLPIRPQAAVVTNASAPAMASTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JUL1</accession>
    <name>A0A2M9JUL1_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">YceI domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_18730</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000005">
        <property type="protein sequence ID" value="PJN10512.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN10512">
        <property type="protein sequence ID" value="PJN10512"/>
        <property type="gene ID" value="CG723_18730"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.128.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007372">
        <property type="entry name" value="Lipid/polyisoprenoid-bd_YceI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036761">
        <property type="entry name" value="TTHA0802/YceI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04264">
        <property type="entry name" value="YceI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00867">
        <property type="entry name" value="YceI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101874">
        <property type="entry name" value="SSF101874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YceI" evidence="1">
        <location>
            <begin position="16"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN10512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="174" mass="18608" checksum="3DD03D28B7EFE708" modified="2018-04-25" version="1">MVASRVGEHPVPESGTYEIDPAASSANFRMRTVFGLFPVRGSFRITRGRIEVAGPVEKSTVDVRIGAHTFESGVARRDEHVRSADYLDAATHPEIAYRADGVEVGSNGPVLTGELTVMGVSRPVGVTVESVAVEGRRLTVVGSAVVDRYAFGVTTAKGLTGRRLTVRLDVRATR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JUM5</accession>
    <name>A0A2M9JUM5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MBL fold metallo-hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_15370</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000004">
        <property type="protein sequence ID" value="PJN10596.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN10596">
        <property type="protein sequence ID" value="PJN10596"/>
        <property type="gene ID" value="CG723_15370"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12706">
        <property type="entry name" value="Lactamase_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lactamase_B" evidence="1">
        <location>
            <begin position="18"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN10596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="250" mass="27006" checksum="92884D5E49DE5227" modified="2018-04-25" version="1">MKLTVVGCSGSFPSADSACSSYLVEADGFRLLLDMGNGALGELQRHCGLYDLDAIFLSHLHADHCIDMCGYFVARYYRHDGGRCAPIPVYGPEGTEQRLTTAYADTPSASSMSEVFDFHTVKPGWHEIGPFTVRTEKVCHPVEAYGIRVEHGGRSLTYSGDTGACVALEELAAGSDLFLCEAAFTHGKENIPDLHLNGREAGESATRAGARRLVLTHIPPWTDPQVNLADARAVYTGPTELAAPGRVYEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-06-02" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JV72</accession>
    <name>A0A2M9JV72_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Phosphopeptide-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CG723_16435</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000004">
        <property type="protein sequence ID" value="PJN10769.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN10769">
        <property type="protein sequence ID" value="PJN10769"/>
        <property type="gene ID" value="CG723_16435"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00060">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000253">
        <property type="entry name" value="FHA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00498">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00240">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SSF49879"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50006">
        <property type="entry name" value="FHA_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FHA" evidence="3">
        <location>
            <begin position="340"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="21"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="102"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="25"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="49"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="108"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="141"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="167"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="190"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PJN10769.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="428" mass="44086" checksum="2FAAB1C8A17C75C1" modified="2018-04-25" version="1">MPTCPNGHQSGSDDWCEVCGHRMAGAVPPPPPPPPPAAGYGYPQGGQTPPPGYGYPPPANAGQSAPPPPGAGPELCPQCRTPREGGAPFCEECRWNFLTNTATSYTPAAPNPPMPGPGQGPGQGPVGPNPALRFQQQPPGPGDSFEYQGSRPSQMNRPAEPIPPFGGDAAQGPPPPPGPRTGGAPQAFQQPGPPAAPQAFQQPGPPAAPQAFQQPGPPAPPAFPQETGRPQGPPGPSGPSFGGGDDWVLSPPSAPAQQGPGPGATEAPGGPQGFPPPQQTQAPQAPQGFQQQQPVSWSATIGPDREYFMAMMHRSGPEASGLNLPAYSPEQQRRLTGNQLTIGRRRHSTGDTPDIDLSVPPEDPGVSHQHAVLVQQPDGSWAVVDQNSTNGTTVNGGDEPIQPFVPVPLQDGDRVHVGAWTTITIHRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-09-29" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JV78</accession>
    <name>A0A2M9JV78_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">zf-HC2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_16520</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000004">
        <property type="protein sequence ID" value="PJN10783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN10783">
        <property type="protein sequence ID" value="PJN10783"/>
        <property type="gene ID" value="CG723_16520"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1320">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041916">
        <property type="entry name" value="Anti_sigma_zinc_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027383">
        <property type="entry name" value="Znf_put"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13490">
        <property type="entry name" value="zf-HC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="102"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="140"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="179"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="222"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="250"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="288"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="domain" description="zf-HC2" evidence="2">
        <location>
            <begin position="15"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN10783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="319" mass="32272" checksum="AA74CCF426EB461E" modified="2018-04-25" version="1">MSGERHGSAWHVGEELAARYADGLLTETDDWSVEKHLESCGACATRVSRAVRAGTAGAELAQIRAAVLADIQGELPAAVEGAASPQGHSLPAGPHRPRRGRLLWAAGPALRGPWALALLLVAAGAVGLGKAGGYEGARPLLLALAPVLPVAGIALSYGRHADPAYELAATSPSGGLRLLLTRAAAVLAVCVPLLTVAGLLLPGTMSAGHGGPVPYEMQVPGAAAWLLPGLALTLASLALTAFLGCRTATLLVGGGWLLALAVPTAARGDSPGRLTERLTEQISVYFDGVAAQTGWAAAIALSGAVLAVCRSAYDHLEKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JVD0</accession>
    <name>A0A2M9JVD0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Phosphohydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CG723_16730</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000004">
        <property type="protein sequence ID" value="PJN10820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN10820">
        <property type="protein sequence ID" value="PJN10820"/>
        <property type="gene ID" value="CG723_16730"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PJN10820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="148" mass="15896" checksum="F524FC50909FAF39" modified="2018-04-25" version="1">MLTLAEVEALARGAHVTQTDKAGRPYAEHLEAVAEGVRARGGDEEQIAAAWLHDAIEDDALSPQWLAAADLTDRTKAVVLALTKRPGEPQEAYAQRILATPGALLVKQSDLAHNADPTRLAALDAPTRDRLTRKYAGMRALLGIDETP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JVD8</accession>
    <name>A0A2M9JVD8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Amino acid permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CG723_16290</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CB01635</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000004">
        <property type="protein sequence ID" value="PJN10747.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN10747">
        <property type="protein sequence ID" value="PJN10747"/>
        <property type="gene ID" value="CG723_16290"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="33"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="68"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="109"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="141"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="169"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="217"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="252"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="298"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="354"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="378"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="410"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="435"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PJN10747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="472" mass="49026" checksum="DAD0F6D0689E92F2" modified="2018-04-25" version="1">MSDTLRTSPSTVTEEPLAPLGNTASPQKLKRSIGVVGGTLLTLSCVTPASTLFVVVPDLFSSLGTATALTIGIGSLLCIAVAFCYSELGTLIPSAGGEYAMVSTLAGRLAGWLVFVLSLLVVMIVPPVIAMGTADYLAPLVHLPAAGAGAGVMLLATLAGLLDLRANAWITGIFLVLEVIAAGVVAVLGFSHSERGAGSLVDLHVTGAGGHTDTVTAMLIISGLAIALFITQGFSTAVYLSEELENPRRNVARTVLLTLAISTVVILVPVVAITMGAPDLAALTSGDISGMVEAWSNSAVGTFVSLCVALAIINAGIVMVIQNSRVLFASARDKSWPEPVNNALSKLGRFGSPWVATLVVGVPGAALCFVNLDTLYGVTGVSVTGMYLLVAVAALLARRGSHRDQPAWRMPLWPAVPVVLIAVLAYILSQQEVSYLLWTGGITAVATLYWALYLRPRKDTRWLVSIPEDAQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JVQ6</accession>
    <name>A0A2M9JVQ6_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Probable potassium transport system protein kup</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">kup</name>
        <name evidence="13" type="ORF">CG723_08195</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">CB01635</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Transport of potassium into the cell.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Cell membrane</location>
            <topology evidence="11">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the HAK/KUP transporter (TC 2.A.72) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN10981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN10981">
        <property type="protein sequence ID" value="PJN10981"/>
        <property type="gene ID" value="CG723_08195"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015079">
        <property type="term" value="F:potassium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01522">
        <property type="entry name" value="Kup"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003855">
        <property type="entry name" value="K+_transporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023051">
        <property type="entry name" value="K+_uptake_low_affin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30540">
        <property type="entry name" value="PTHR30540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02705">
        <property type="entry name" value="K_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 11" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9 11" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 11" id="KW-0630">Potassium</keyword>
    <keyword evidence="5 11" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="32"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="73"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="125"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="166"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="196"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="228"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="273"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="314"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="360"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="390"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="422"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="449"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01522"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PJN10981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="656" mass="70765" checksum="29595069E7F0AA25" modified="2018-04-25" version="1">MADRRQEPSSDDGSPSRTLDARRANARDTVRLAVVIGALGVVFGDIGTSPIYTLQTVFNPDDPHPVPVSTENVYGVVSLVFWSVMIIVTVTYVLLAMRADNDGEGGIMALITLLRRLSSQHGRRAAVVLAALGIFGASLFFGDSMITPAISVLSAVEGLKVVEPSLEDAVVPITAVIIVILFLVQRRGTAAVGRVFGPVMIAWFVAIGACGVAGITDHPDILKALSPTYALGFLFGHWGTAFFALAAIVLSVTGAEALYADMGHFGRRAITRGWLFLVLPACVLSYLGQGALILDDPDNISSPFFLLVPGWGRWPMVLLATAATVIASQAVITGAYSVASQAAQLGYLPRLRIAHTSESTIGQIYVPWINWLLMVSVLTLVFAFRSSAALAYAFGMAVTGTITITTLLFFYVARAKWGTPRWLLGIGAGVLLFVDLLFVAANMTKLVHGAWLPLLIGLTAFTVMTTWQRGRELVTAERARAEGPLPEFVDDLRSGKASTLQVPGTAVFLNRGKETTPLAMRANVVHNHVRHEQVVILALQTEPVPRVPADQRIVVDDLGYADDGIVHVTARFGYMETPDVPGLLATLDPAETEGPLQLDQASYFLSKIELRRGKAPTMAPWRKRLFIATSYITSDAAEYFSLPRDRTVIMGSHIEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JVR6</accession>
    <name>A0A2M9JVR6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_16895</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000004">
        <property type="protein sequence ID" value="PJN10847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN10847">
        <property type="protein sequence ID" value="PJN10847"/>
        <property type="gene ID" value="CG723_16895"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN10847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="153" mass="16883" checksum="2887E7C75C31EF8E" modified="2018-04-25" version="1">MRRARPGATSRGSAERALTSVAAGESYQGSGQEESAVTEEGPRLWHVTLSVSGADAPLAEVRRGLEQLAHDHPFLLTSRYAVDHAEIRYWEEARDLHDAAAVALRLWGEHRQSSQLPPWEIVGLEVIDRDTYHQRIAEGYGPLPATPVGVHPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JW03</accession>
    <name>A0A2M9JW03_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Gas vesicle protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CG723_08380</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN11008.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN11008">
        <property type="protein sequence ID" value="PJN11008"/>
        <property type="gene ID" value="CG723_08380"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007804">
        <property type="entry name" value="Gas-vesicle_GvpG"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05120">
        <property type="entry name" value="GvpG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PJN11008.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="84" mass="9503" checksum="2352587996E0F340" modified="2018-04-25" version="1">MGLITGILTLPIAPVRGVIWVAEKLNDAAERELHDPGVLRAQLALLNRELEDGDISLEEFEREEERLLDRLYSTRVGPAPNDRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JWJ2</accession>
    <name>A0A2M9JWJ2_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">5'-nucleotidase</fullName>
            <ecNumber evidence="3">3.1.3.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CG723_09585</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CB01635</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a ribonucleoside 5'-phosphate + H2O = a ribonucleoside + phosphate</text>
            <dbReference type="Rhea" id="RHEA:12484"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:18254"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58043"/>
            <dbReference type="EC" id="3.1.3.5"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SurE nucleotidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.5" evidence="3"/>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN11188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN11188">
        <property type="protein sequence ID" value="PJN11188"/>
        <property type="gene ID" value="CG723_09585"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106411">
        <property type="term" value="F:XMP 5'-nucleosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1210.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030048">
        <property type="entry name" value="SurE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002828">
        <property type="entry name" value="SurE-like_Pase/nucleotidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036523">
        <property type="entry name" value="SurE-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30457">
        <property type="entry name" value="PTHR30457"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01975">
        <property type="entry name" value="SurE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64167">
        <property type="entry name" value="SSF64167"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014889852" description="5'-nucleotidase" evidence="6">
        <location>
            <begin position="24"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="domain" description="SurE" evidence="7">
        <location>
            <begin position="58"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PJN11188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="371" mass="37861" checksum="FB73E2B3289E085F" modified="2018-04-25" version="1">MPTTSRSRIMLATAATAATAATAAVLASLTAVAYALPQATEAAAHAEPSAEPLAGLRVLLSNDDSMQAAKASHADGLGLYEMRKALCAAGADVVVMAPWQVQSGKGTAVTNGGALTLARRTRLPAGYENDCSGVPSGSPVYGVCLSDDACGAGTPSATPADTVKFALRSGLAAKVGWADGPDVVVTGINSGPNVSAQVNDSGTVGAAVAAIDDGVPAIAFSSSSGDSTNTYFPVANYRDNAEFGARLLAGMRERSLFTGKFAVKVDYPDVSGGRRAKPPLWTGIGHGKVVWHDYAARRGSGDTFDIVPGVCADRPGDSCTETVRRADSTALLSGHVAVAPVTADRTYGAIVDGGKNLRKLKHYVEQDAPRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JWR3</accession>
    <name>A0A2M9JWR3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Aldehyde oxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CG723_10025</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CB01635</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the xanthine dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN11262.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN11262">
        <property type="protein sequence ID" value="PJN11262"/>
        <property type="gene ID" value="CG723_10025"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00207">
        <property type="entry name" value="fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002888">
        <property type="entry name" value="2Fe-2S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036884">
        <property type="entry name" value="2Fe-2S-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036010">
        <property type="entry name" value="2Fe-2S_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001041">
        <property type="entry name" value="2Fe-2S_ferredoxin-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006058">
        <property type="entry name" value="2Fe2S_fd_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000674">
        <property type="entry name" value="Ald_Oxase/Xan_DH_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036856">
        <property type="entry name" value="Ald_Oxase/Xan_DH_a/b_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016208">
        <property type="entry name" value="Ald_Oxase/xanthine_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008274">
        <property type="entry name" value="AldOxase/xan_DH_Mopterin-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037165">
        <property type="entry name" value="AldOxase/xan_DH_Mopterin-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11908">
        <property type="entry name" value="PTHR11908"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01315">
        <property type="entry name" value="Ald_Xan_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02738">
        <property type="entry name" value="Ald_Xan_dh_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01799">
        <property type="entry name" value="Fer2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01008">
        <property type="entry name" value="Ald_Xan_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47741">
        <property type="entry name" value="SSF47741"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54292">
        <property type="entry name" value="SSF54292"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54665">
        <property type="entry name" value="SSF54665"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56003">
        <property type="entry name" value="SSF56003"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00197">
        <property type="entry name" value="2FE2S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51085">
        <property type="entry name" value="2FE2S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="2Fe-2S ferredoxin-type" evidence="3">
        <location>
            <begin position="1"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PJN11262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="906" mass="96687" checksum="14F23F7983C1E80B" modified="2018-04-25" version="1">MTYVVNGRGFDEEPGPGQCLRTFLRSLGHHGVKKGCDAGDCGACTVWLDGDPVHSCITPAFRAEGHEVTTIEGLGSPGQLHPMQRQFRDAPGFQCGFCTAGMIMTSATFTEAQKADLPRALKGNLCRCTGYRAIEDAVKGIVGVETAAPGKAVGTSVGAPAGDEVVTGRAEFTMDTDVEGLLHLKVLHSPHAHARIVSVDKTAALAVPGVHRVYTWEDVPRRRFSTAIHTDHLADPDDTYILDDTVRFVGQRVAAVVADTVGAAEEGCRRVEVEYEELPAVFDPEAAMAEGAPQLHGTDDPFVRDAVHNILLEIHSHIGDVDAGFAEADVIHEGTYSSPRVQHAHLETHGSIAWVENGRLIVRTSSQSPSIAKIKLAHLFALRPDQLRVFCKRVGGGFGGKQEVISEDLAALAALDTGRPVCFEYTREEEFTTASPRHPMTLTVRLGAKADGTLTAFQVRNVSNTGAYGNHGGETLYAGGAAVMIYRCPNKKYDGFSVYTNTVPSGALRGYGMTQPAYAVESAMDELARALHLDPLELRRRNIVRPGDPLVAMHDGPDDVMFNENGLGKCIDLVDHAMARAVDEPPPGPGWLVGSGVASSLHETAPPTEHLSEAWVTLGDDLVYELAVGTVEFGEGTSTAHVQIAANQLGTTPSRIRLVQSDTDRTGFDTGAFASAGLFVAGNAVLRAANAVRDRILEFAAAHTGVHVVMCSLGDGEVVCGDQRVPLAELVSLARARGIRFTAARKAYGSPRSVVSNTQGFKIAVHQVTGEIRILYSVHATDAAVVINPAQLRGQVEGGVAQGIGFTLTENYQVDAGGAMANPNLRNYRIPTYADVPRTELFLVKSADSFGPMGSKGMAECCINPVAPALANALHDATGVRCRALPLTPERIYSRLRDNRAIRTAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JWZ8</accession>
    <name>A0A2M9JWZ8_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase</fullName>
            <ecNumber evidence="10">2.1.1.14</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Cobalamin-independent methionine synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Methionine synthase, vitamin-B12 independent isozyme</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">metE</name>
        <name evidence="13" type="ORF">CG723_10485</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">CB01635</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 10">Catalyzes the transfer of a methyl group from 5-methyltetrahydrofolate to homocysteine resulting in methionine formation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>5-methyltetrahydropteroyltri-L-glutamate + L-homocysteine = L-methionine + tetrahydropteroyltri-L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:21196"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:58140"/>
            <dbReference type="ChEBI" id="CHEBI:58199"/>
            <dbReference type="ChEBI" id="CHEBI:58207"/>
            <dbReference type="EC" id="2.1.1.14"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="10">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 10">Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; L-methionine from L-homocysteine (MetE route): step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the vitamin-B12 independent methionine synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.14" evidence="10"/>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN11348.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN11348">
        <property type="protein sequence ID" value="PJN11348"/>
        <property type="gene ID" value="CG723_10485"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00051">
        <property type="reaction ID" value="UER00082"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003871">
        <property type="term" value="F:5-methyltetrahydropteroyltriglutamate-homocysteine S-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009086">
        <property type="term" value="P:methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03311">
        <property type="entry name" value="CIMS_C_terminal_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.210">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00172">
        <property type="entry name" value="Meth_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013215">
        <property type="entry name" value="Cbl-indep_Met_Synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006276">
        <property type="entry name" value="Cobalamin-indep_Met_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002629">
        <property type="entry name" value="Met_Synth_C/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038071">
        <property type="entry name" value="UROD/MetE-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08267">
        <property type="entry name" value="Meth_synt_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01717">
        <property type="entry name" value="Meth_synt_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000382">
        <property type="entry name" value="MeTrfase_B12_ind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51726">
        <property type="entry name" value="SSF51726"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01371">
        <property type="entry name" value="met_syn_B12ind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="7 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 10" id="KW-0486">Methionine biosynthesis</keyword>
    <keyword evidence="4 10 13" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 10 13" id="KW-0808">Transferase</keyword>
    <keyword evidence="8 10" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Meth_synt_1" evidence="12">
        <location>
            <begin position="13"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="domain" description="Meth_synt_2" evidence="11">
        <location>
            <begin position="441"/>
            <end position="763"/>
        </location>
    </feature>
    <feature type="region of interest" description="5-methyltetrahydropteroyltri-L-glutamate binding" evidence="10">
        <location>
            <begin position="24"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="L-homocysteine binding" evidence="10">
        <location>
            <begin position="446"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="region of interest" description="L-methionine binding" evidence="10">
        <location>
            <begin position="446"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="region of interest" description="5-methyltetrahydropteroyltri-L-glutamate binding" evidence="10">
        <location>
            <begin position="530"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="10">
        <location>
            <position position="709"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="120"/>
        </location>
        <ligand>
            <name>5-methyltetrahydropteroyltri-L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:58207"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="499"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="576"/>
        </location>
        <ligand>
            <name>5-methyltetrahydropteroyltri-L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:58207"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="614"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="620"/>
        </location>
        <ligand>
            <name>5-methyltetrahydropteroyltri-L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:58207"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="656"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="658"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="680"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="741"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF08267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PJN11348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="772" mass="82926" checksum="6A9594280B17E079" modified="2018-04-25" version="1">MTTDTAAAAARATVYGYPRQGPARELKKAVEGYWNGHVGADALRSTAAGLRRANWHELADAGIGEVPTGDFSFYDHVLDATVMVGAVPERHRAAVEADALDGYFAMARGTQGVAPLEMTKWFDTNYHYLVPELGPGTVFTADSAKQVAELKEALALGLPARPVLVGPVTYLLLAKPAPGVAADFEPLTLLDRLLPVYAEILADLREAGAEWVQLDEPALVQDRTPAELNAAGRAYRDLGALTDRPKMLVASYFDRLGDALPVLAGAPVEGLALDFTERAAANLDALAAVGGLPGKRLVAGVVNGRNIWVDDLEKSLATLGTLLGLADRVDVAASCSLLHVPVDAALERDIEPQILRWLAFARQKTAEIATLARGLTQGTHAISAQLAANRADLASRTTSTLTRDPAVRARTAAVSPADARRAQPYAERAAAQRGSLGLPLLPTTTIGSFPQTAELRTARAGLRAGRIDDAAYEERVRAEIQEVIAFQEKAGIDVLVHGEPERNDMVQYFAEQLTGYLATQHGWVQSYGTRCVRPPILAGDISRPEPMTVRWTTYAQSLTGRPVKGMLTGPVTMLAWSFVRDDQPLADTARQVALALRDEVDDLERSGTSVIQVDEPALRETLPLRAADHAAYLAWATEAFRLTTSGVRPDTQVHTHMCYAEFGDIVQAIDDLDADVISLEAARSHMQVARELDAHGYPREAGPGVYDIHSPRVPGAGEAAALLRKGLEAIPAERLWVNPDCGLKTRGWPETRASLENLVAAARTVRGELSAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JX69</accession>
    <name>A0A2M9JX69_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Polyketide cyclase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CG723_10910</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN11418.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN11418">
        <property type="protein sequence ID" value="PJN11418"/>
        <property type="gene ID" value="CG723_10910"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019587">
        <property type="entry name" value="Polyketide_cyclase/dehydratase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10604">
        <property type="entry name" value="Polyketide_cyc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PJN11418.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="152" mass="16382" checksum="0786101CC6C02F09" modified="2018-04-25" version="1">MAGQFEATFVVARSVDEVFEYLADGRNDPQFSPRVLKIERVPDTPTTVGTVFRSTVKDAGMKSAREFRITALDAPVKIRWAEVSKNSVMAREGGYDLEPMPDGGTQVRIFNVLEGHGVGKLLVGLALSAARTDADAFGARIKAATEAAIAPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JXE3</accession>
    <name>A0A2M9JXE3_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Bifunctional cytochrome P450/NADPH--P450 reductase</fullName>
        </recommendedName>
        <domain>
            <recommendedName>
                <fullName evidence="8">Cytochrome P450</fullName>
                <ecNumber evidence="8">1.14.14.1</ecNumber>
            </recommendedName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="8">NADPH--cytochrome P450 reductase</fullName>
                <ecNumber evidence="8">1.6.2.4</ecNumber>
            </recommendedName>
        </domain>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CG723_11690</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">CB01635</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>NADPH + 2 oxidized [cytochrome P450] = H(+) + NADP(+) + 2 reduced [cytochrome P450]</text>
            <dbReference type="Rhea" id="RHEA:24040"/>
            <dbReference type="Rhea" id="RHEA-COMP:14627"/>
            <dbReference type="Rhea" id="RHEA-COMP:14628"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:55376"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
            <dbReference type="EC" id="1.6.2.4"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]</text>
            <dbReference type="Rhea" id="RHEA:17149"/>
            <dbReference type="Rhea" id="RHEA-COMP:11964"/>
            <dbReference type="Rhea" id="RHEA-COMP:11965"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:30879"/>
            <dbReference type="ChEBI" id="CHEBI:57618"/>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
            <dbReference type="ChEBI" id="CHEBI:142491"/>
            <dbReference type="EC" id="1.14.14.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <cofactor evidence="8">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8 9">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">In the N-terminal section; belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.14.1" evidence="8"/>
    <dbReference type="EC" id="1.6.2.4" evidence="8"/>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN11553.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN11553">
        <property type="protein sequence ID" value="PJN11553"/>
        <property type="gene ID" value="CG723_11690"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070330">
        <property type="term" value="F:aromatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003958">
        <property type="term" value="F:NADPH-hemoprotein reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.990.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023206">
        <property type="entry name" value="Bifunctional_P450_P450_red"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003097">
        <property type="entry name" value="CysJ-like_FAD-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008254">
        <property type="entry name" value="Flavodoxin/NO_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023173">
        <property type="entry name" value="NADPH_Cyt_P450_Rdtase_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001433">
        <property type="entry name" value="OxRdtase_FAD/NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00667">
        <property type="entry name" value="FAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00258">
        <property type="entry name" value="Flavodoxin_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00175">
        <property type="entry name" value="NAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000209">
        <property type="entry name" value="Bifunctional_P450_P450R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="SSF48264"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52218">
        <property type="entry name" value="SSF52218"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="SSF52343"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="SSF63380"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50902">
        <property type="entry name" value="FLAVODOXIN_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0249">Electron transport</keyword>
    <keyword evidence="4 8" id="KW-0274">FAD</keyword>
    <keyword evidence="2 8" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3 8" id="KW-0288">FMN</keyword>
    <keyword evidence="8 9" id="KW-0349">Heme</keyword>
    <keyword evidence="8 9" id="KW-0408">Iron</keyword>
    <keyword evidence="8 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 8" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5 8" id="KW-0521">NADP</keyword>
    <keyword evidence="6 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Flavodoxin-like" evidence="10">
        <location>
            <begin position="492"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding FR-type" evidence="11">
        <location>
            <begin position="672"/>
            <end position="897"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="9">
        <location>
            <position position="405"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR000209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000209-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PJN11553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="1055" mass="112964" checksum="E1C14CD7DF9A8CC0" modified="2018-04-25" version="1">MPDSALLPPAPTDGLPLIDISATGPGPAPLQQAMELTRRHGPALVRRLHGRDALFVSDLDLVTELADETRFAKHVGPALENVRNFTADGLFTAYNDEPNWARAHDILMPAFALGSMRTYHPVMYQVSRRLIESWDRAARSGSPVDVPGDMTRMTLDTIGLAGFGYDFGSFEGSEPHPFVEAMVRCLEWSMKRLARTPGADHSAADAAFKADADYLAQVVDDVIAARTDAPEGDDLLGLMLTARHPDGSALDTANIRNQVITFLIAGHETTSGAMSFALYYLAKHPAVLDLVRREADALFGDAADPEPTFDEVGRLTYTRQVLNEALRLWPTAAAFSRHAREDTLLGGRIPLRAGQAVTVLAPMLHRQPVWGDNPELFDPSRFTPEAEAARSPHAFKPFGTGERACIGRQFALHEATMLLALLVHRYRLVDHADYELTVKETLTLKPEGFTLTLVPRTSADRNHPALPGHAPVEERTAAPDTLPARVRPGTGVLFLHGSNYGTCRGLAEQLADDVAALGCDTAVAPLDTHAGALPTDRPVVVVAASYNGRPTDDAAEFATWLDGAQDGAANDVTYAVLGVGDRNWAATYQHVPTRIDERLDALGGTRLCERAAADASGDLNATVRTFTTGLRAALLTQYGDPDAAPADAAEPEDAYEIREIGGGPLDAAAARHGLVPFTVTEASSLTAPDHPRTKRFVRLALPEGVTYRTGDHLTVLPAQDPALVERTAAAFGVGLDTVLDIRARRPRRDGLALDRPLTVRQLLTSHVELGHAPTPAQVALLAEANPCPPEKAALAALADDPRTLVELVEDHPALRGALTWPQLLDLLPPLKPRHYSISSSAERSPTHADLMVSVLDAPARSGRGRFRGTGSAYLAGLRPGDTVLARVQPCREVFRVPNDSETPVVMIAAGTGLAPFRGAVADRGALLAAGTPLAPALCYFGCDHPQGDFLHADELRAAEAAGAVSLRPVFSEAPEAGHAFVQHRVAAEADELWALLGAGARVYVCGDGARMAPGVRDAFRALFRDRTPGADDDAAERWLAGLVVDGRYVEDVYAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-05-25" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JXS7</accession>
    <name>A0A2M9JXS7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">LacI family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CG723_12425</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN11671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN11671">
        <property type="protein sequence ID" value="PJN11671"/>
        <property type="gene ID" value="CG723_12425"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01392">
        <property type="entry name" value="HTH_LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000843">
        <property type="entry name" value="HTH_LacI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046335">
        <property type="entry name" value="LacI/GalR-like_sensor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00356">
        <property type="entry name" value="LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13377">
        <property type="entry name" value="Peripla_BP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00354">
        <property type="entry name" value="HTH_LACI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50932">
        <property type="entry name" value="HTH_LACI_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH lacI-type" evidence="5">
        <location>
            <begin position="11"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="337"/>
            <end position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PJN11671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="356" mass="37859" checksum="11DB3EEAE10AED88" modified="2018-04-25" version="1">MPAKRSPARRPTMKDIALRAGVSESAVSFALNDRPGVSEVTRDRVRRVAEQLGWRPSTAARALSGEGAATVGLVVARPADTLGVDSFFLQLISGIQEVLAERHLGLLFQVVEDVEAECAVYRRWWAEHRVDGVLVVDPRTADPRPALLDELGLPAVVIGGVPDAEHPGMSTVWADDAGAMASVVDELYALGHRRIVHIAGLPGLAHTERRIRTLRAEAERRGLTEVRSVTTDYSDAEGAAVTRRVMEGDTPPTALVYDNDVMAVAGVAAAGELGFSVPGDVSVVAWEDSPLCRMVKPWLSALSRDTVQFGRTAAQELTALLDGGPSRTVQVPLPRLIERDSTGAARGAETGASGGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JXU1</accession>
    <name>A0A2M9JXU1_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Maltokinase</fullName>
            <ecNumber evidence="5">2.7.1.175</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Maltose-1-phosphate synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CG723_12370</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CB01635</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + D-maltose = ADP + alpha-maltose 1-phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:31915"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17306"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:63576"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.175"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Glycan biosynthesis; glycogen biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the aminoglycoside phosphotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.175" evidence="5"/>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN11662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN11662">
        <property type="protein sequence ID" value="PJN11662"/>
        <property type="gene ID" value="CG723_12370"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00164"/>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005978">
        <property type="term" value="P:glycogen biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040999">
        <property type="entry name" value="Mak_N_cap"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18085">
        <property type="entry name" value="Mak_N_cap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0418">Kinase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Mak_N_cap" evidence="9">
        <location>
            <begin position="28"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="domain" description="APH" evidence="8">
        <location>
            <begin position="175"/>
            <end position="405"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001537"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00013882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00031251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF18085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PJN11662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="456" mass="50205" checksum="80A9BC6CE919A7F0" modified="2018-04-25" version="1">MPKAALQSPTGVSPSLLLNSLAGLLHEWLPRQRWFAGKGRPVTGLTLASMTELHPGCLHLLVRAEHAAQATRSGSGTPPADNLYQLLLGVREMLPPSLAPAFIGRATEGPLTGLMVYDALQEPRSAGLLLERLRHPAAAGPLRFERDPQVTVPAGLTPRVLDAEQSNTSLVYGDSFILKVFRRVQAGVNPDLEVPWALARQGCTRVPGPVAWFRTSQPQKATLGVLQPFLPDADDGWTLALRSLASGRDFTDEAYELGRATAEIHLALTAAFPVDAPVPHRNRHLAEAMTERLESTARSVPAVLPHAPGLRAAFDAFALVDSAWPAQRIHGDLHLGQVLWSGQQWFVIDFEGEPARPLAERRHAQSPVRDVAGMLRSFDYAARTRLPWRPEWSLRCRDAYCAGYAAESKSDPREEPDLLRAFETDRALYEVLYEARHRPDWLPVPMAAISRLAEPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JY36</accession>
    <name>A0A2M9JY36_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ABC transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CG723_12535</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN11687.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN11687">
        <property type="protein sequence ID" value="PJN11687"/>
        <property type="gene ID" value="CG723_12535"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="11"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="344"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="272"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="43"/>
            <end position="50"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="376"/>
            <end position="383"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PJN11687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="553" mass="59767" checksum="E2E8E4B120CDB92B" modified="2018-04-25" version="1">MATPTAPSASLTCSGLSFQWQDGTPVLDGLSLAIGRGRTGLVGTNGTGKSTLLRLLAGQLAPSQGSVTVGGSLAYLPQNITLDTAMRVDQALGIAERRAALRAIENGDVSEEHFDTVGDDWDVEERALATLGSLGLADVELDRTVGQLSGGETVLLRLAALLLERPDILLLDEPTNNLDVFARRRLYEAVDSWRSGVLVVVSHDRELLERVDRIAELRSGSVSWYGGGWSAYEEALATQQEAAGRMLRAAEADVRRQKRELEETQIKVARRARQSKKLDAQRKAPRIVAGEKKRSAQESGDKLRGLHEDRLGEAHERREEAAEAIRNDAEIRVSLPHTAVPTGRTVLSLDELSLPHGKLRDGSLHIHGPERIALVGRNGAGKTTLLRTLTGELEPLSGEAKTFVPLRFLPQRLDVLDEQLSVAANVARMAPGVTDNHIRSQLARFLFKGARAEQPAGTLSGGERFRAALAATMLAAPAPQLLMLDEPTNSLDMASVRQLTSALGSYEGALLIASHDLPFLESIGITRWLLLGEDLQETTAEEVRDLLEAPEAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JY46</accession>
    <name>A0A2M9JY46_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cupin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_12595</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN11697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN11697">
        <property type="protein sequence ID" value="PJN11697"/>
        <property type="gene ID" value="CG723_12595"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013096">
        <property type="entry name" value="Cupin_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07883">
        <property type="entry name" value="Cupin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cupin_2" evidence="1">
        <location>
            <begin position="20"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN11697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="99" mass="10875" checksum="EECBD674FA367629" modified="2018-04-25" version="1">MTTTAKPSVQHEDEQVRVTRWDFEPDTRTGRHVHEHDYVVVPVVDGRISAFAPDGTVTDSQLRAGESYARPAGGEHDVVNTGGTWLAFVEIELKGTSKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JYA8</accession>
    <name>A0A2M9JYA8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NAD(P)-dependent oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_13580</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN11860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN11860">
        <property type="protein sequence ID" value="PJN11860"/>
        <property type="gene ID" value="CG723_13580"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016040">
        <property type="entry name" value="NAD(P)-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13460">
        <property type="entry name" value="NAD_binding_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD(P)-bd_dom" evidence="1">
        <location>
            <begin position="6"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN11860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="287" mass="29865" checksum="5B7089C5A25E3D37" modified="2018-04-25" version="1">MIVVTGATGKLGRQIAESLLTHVPADRVGVSVRDPQKAQDLADRGVRVRQGSFSDAAGLAHAFEGASQVLIVSVDKMGEEAVRQHRAAIEGAVAAGARRILYTSHMGASATSHFEPCRDHAAAEETLRTCGVPYTALRNGFYATSALQFLGHGLESGEAELPADGPVSWTAHADLADAAAAVLADEGRFEGPTPPLTAAQALTFDDIAGIASEAQGRSVKRITTPDDAFREQLVGHGVPAEAADQLLGVFTASRAGEFATVDPTLANLIGREPTSLSTVLREHLGGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JYE4</accession>
    <name>A0A2M9JYE4_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">HTH tetR-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CG723_13725</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN11884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN11884">
        <property type="protein sequence ID" value="PJN11884"/>
        <property type="gene ID" value="CG723_13725"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039538">
        <property type="entry name" value="BetI_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13977">
        <property type="entry name" value="TetR_C_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0678">Repressor</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="3">
        <location>
            <begin position="31"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="2">
        <location>
            <begin position="54"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PJN11884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="233" mass="25497" checksum="0023115F7CBACAD9" modified="2018-04-25" version="1">MRTSCLLGWASIASQVMTSTSRTGRRRLPAGERRAEILRAASVIAVSEGLDKLTAKRVAQAVGVVPGLVDYHFKSADELIAAAFSHAATADNDAVFEHAERLDHPVDRVRQLMQAWLHEDRDPVSLLWLDAWQASRRRPALLTAVTRQMNAAQDRLAAHIEAGVARGCFRVDNAGYAAMHILVLIDGLSPQAAMRTQIDYAEVRELITATTERVLGLDEGVLAQAQDHGRTDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-05-25" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JZ00</accession>
    <name>A0A2M9JZ00_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_09385</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN12113.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN12113">
        <property type="protein sequence ID" value="PJN12113"/>
        <property type="gene ID" value="CG723_09385"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008969">
        <property type="entry name" value="CarboxyPept-like_regulatory"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49464">
        <property type="entry name" value="SSF49464"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="9"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="139"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="170"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="199"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="224"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="273"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN12113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="444" mass="46165" checksum="F1649199CFFE5F80" modified="2018-04-25" version="1">MAKVLAEAAWFPAVLFLGVIFFFAPALHAPGPHHVKVVVAGGAEANRVDTKLRAQTAGGFDVTAVAGREQARQAVLDRDAFAGYAVDGGHPVLYVAKANGASLEQTLITFFSKVAGTSDPLTVRDVAPTTAEDPMGSNVLYFGIAWNIPAYILATTLLRAVTLNRRRKLLALAVVAAVFSAVGYAVGVGLGYLNPDPSVMAVAFLLTTAVATTASGLAPFTGRFLPAVGMTLFIVMSIPTSGGAVPAPLLPEFYQDVHAVMPLANAIDALRGILYFGGAGVLKPVLVLCGWIAGGVALLALDHGRRKRAAIEEAVAEPPADDPALEMPVPTALPVHRHHFGEPVPALAGMVRGVDGEPVRGAVVVVLDSRGRQLVNTVTDEQGGYAVAGLPEGHLGIVASAPGRHPLALRKLLRAGETVDADFTLRGREESAVDTESGRLTASR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JZ29</accession>
    <name>A0A2M9JZ29_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Peptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_10830</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN12143.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN12143">
        <property type="protein sequence ID" value="PJN12143"/>
        <property type="gene ID" value="CG723_10830"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001466">
        <property type="entry name" value="Beta-lactam-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00144">
        <property type="entry name" value="Beta-lactamase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014773747" evidence="1">
        <location>
            <begin position="28"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-lactamase" evidence="2">
        <location>
            <begin position="55"/>
            <end position="371"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN12143.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="380" mass="41631" checksum="9B9FDFD6FA5E8E02" modified="2018-04-25" version="1">MTFLSRRSLLAGSAAAGAMLVGTGRAAAHTPSGSGSPDTRALKEAISDLTHPPATSAQLLVDRPGQRWYGTSGVADIRTARRVRPDDAFRAGSVTKAFVATVVLQLWSRGLVDLDEPIGRHLPGLLPAESARITVAQLLNHTSGLPDHRDLPDVSTPEAVLRHRFDRWTPEELVRTVTLDPLKFRPGSKQEYRGINYVLLALLVEAVTGRPYGEVIRERVVRPLGLRGTLIPDRDPRLHGSHVHGYLKMTGGSLRDVTVYDQSSAWGEGELVSTVADLFRFHQALLSGELLPPHAMNHLFTLPPDSVRMLDGGPARYSLGLQQATVNGVTFWGKTGDTYGYRTRVFSTRDQQLRWVLAYTRTPLASPEDMTNRVVSVLTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JZ42</accession>
    <name>A0A2M9JZ42_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CG723_10730</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CB01635</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN12139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN12139">
        <property type="protein sequence ID" value="PJN12139"/>
        <property type="gene ID" value="CG723_10730"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045621">
        <property type="entry name" value="BPD_transp_1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19300">
        <property type="entry name" value="BPD_transp_1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014955088" evidence="6">
        <location>
            <begin position="37"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="107"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="154"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="196"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="296"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="7">
        <location>
            <begin position="107"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PJN12139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="330" mass="34416" checksum="2BB119DE82B5240C" modified="2018-04-25" version="1">MKRRLPWGPMARLTGRRILFAVPVLAIVTFGVFAIAAASPFDPVKAYAGTAGLTSSQDNLDQLRANLGVDRPLVTRWWDWLTSALRGDLGDSSVLRQPVAAVVGERIGWSVLLAATAFLAAVLLGTALGVLAARRQGGWLDRAVSAVAYTLEAAPPFWLGLLAVWLFALKLGALPAGGLTDTGSTTITAGQVASHLVLPAAVLAVSQLPWFVLYVRQGVGDALEEDPVRGARARGLAPRTVLIGHALRSGMLPVLTLVGSRVPELITGALLVETVFSWPGIAAATVQAATSVDFPLLAALTVLATLAVLLGNLAADLLYGLADPRVGFDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JZC7</accession>
    <name>A0A2M9JZC7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">TetR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_04040</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000002">
        <property type="protein sequence ID" value="PJN12243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN12243">
        <property type="protein sequence ID" value="PJN12243"/>
        <property type="gene ID" value="CG723_04040"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023772">
        <property type="entry name" value="DNA-bd_HTH_TetR-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041478">
        <property type="entry name" value="TetR_C_27"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17935">
        <property type="entry name" value="TetR_C_27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01081">
        <property type="entry name" value="HTH_TETR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="5"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="28"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN12243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="196" mass="21875" checksum="AB1656EFC0F565D9" modified="2018-04-25" version="1">MATETLTTERILEATEEVLRRHGPAKATVVDVARALGVSHGSVYRHFGTKAQLREAVTKRWLDRTTNELQLLTTDGSLTSPALLRQWFSTLFAAKRRKAGDDPQLFATYQVLISENSRVVELHVGELIMQLDHIIQDGVARGEFSLPHPDPALTARAVFDATNRFHDPAYAGEWQKAGIDEEFRALTDLVLRGLNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JZI9</accession>
    <name>A0A2M9JZI9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Peptidase S8</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CG723_04295</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000002">
        <property type="protein sequence ID" value="PJN12284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN12284">
        <property type="protein sequence ID" value="PJN12284"/>
        <property type="gene ID" value="CG723_04295"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000209">
        <property type="entry name" value="Peptidase_S8/S53_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022398">
        <property type="entry name" value="Peptidase_S8_His-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023828">
        <property type="entry name" value="Peptidase_S8_Ser-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015500">
        <property type="entry name" value="Peptidase_S8_subtilisin-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017296">
        <property type="entry name" value="Peptidase_S8A_SAM-P45"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00082">
        <property type="entry name" value="Peptidase_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037852">
        <property type="entry name" value="Subtilisin_rel_SAV5721"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00723">
        <property type="entry name" value="SUBTILISIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="SSF52743"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00137">
        <property type="entry name" value="SUBTILASE_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00138">
        <property type="entry name" value="SUBTILASE_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0720">Serine protease</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014715279" evidence="4">
        <location>
            <begin position="30"/>
            <end position="1224"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_S8" evidence="5">
        <location>
            <begin position="221"/>
            <end position="478"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PJN12284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="1224" mass="127183" checksum="63F75DB3C0AC0558" modified="2018-04-25" version="1">MTRGPARRSAALLSAGLALALLPGGQAVAGDTATPAARATTPAARAAHTVTLVTGDKVTVTDLGGGKKAVTVDRAKGATGAVRTQVNDGKISVVPDEARPYLAAGTLDARLFDVSELIRQGLADSKADATPLIVSYAGKSARSAARTPKGADRTRGLDSIGGAALDAGKGRTFWNAVTAPEGKDFADGIGKIWLDGRVKADMAESNEQIGTPKAWEAGLTGKGVKVAVLDTGYDATHPDLASRVTESKSFIEGQEVADGNGHGTHVTSTVGGSGAASDGKEKGVAPDATLAVGKVLSNQGSGSESQIIAGMEWAAKDIHAKVVSMSLGSSEASDGTDPMAAAVNSLSKETGALFVIAAGNSGAPGSIGSPGAADSALTIGAVDSADEAAYFTSKGPRFGDNGLKPDLSAPGVGILAARSSLVPGSGAYTSMSGTSMATPHVAGVAALLAQKHPDWTGAQLKDALMSTSKELADSAYDLGSGRVSVPDAVTADVTATGSADLGYYKWPYESNKPVTKTVTYSNSSDSAVELTLTAEGAADGVVSLADSKLTVPAHGTASTTVTGDGAKAAVGNTSGRIVASVAGKPVAHTAFGMVKEEERYTLTVHVKDRDGAATAAYLGVQQLVGNTDPFPATVGDSGTLQLRLKPGSYYVESYLDVHGSHGKDSLGLGYLADPEIKLDRDREITLDGRQLKEVKADVGRTTETRHLLMEADRKAGGADYMSAVQLPVKYDSIFAASTHKVTDGSFEYRTVWRLGKPTLQVDGLREAVVQPGSSLTEGRSRLAVVDAGAGAPADYAGKNVRGRAVLVRRTDALSPAQLAQAAQDAGVKALFVTDGAAGRLNAWFGTDDDTDRPLQIATVDSADGAKLAADAKAGRSVTMTGTRNTPWVYDVTDEHKGAVPSGDLTYRPRKSDLAVIDAKFHAVKPQAGGEFRYSITDTFRIGLGFLQKIDYPAERTDYVSTGTGQKWHESVQTGPTDLEQRSGLITYKGGKHSELDWFKPVWHPWLGTGLGWGQQRSGDTLQFNVPGWGDSGPDHTGFGDVWSDSTQTQNSEVYVDGVLADRKKSSAVYVWDADPAEHTYKVVTDTTLDAARWKLATKGHSEWTFKSAETPDDRWTFLPLLNLGFDVDTDLAGNVRGGHRVSVGISSEYVKGAPDTGKIGGGTLEASYDDGKTWTKVALDGHGASWKGTLKVPGDAQYVSLRASASDDRGGKVTQEIIRAVGVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JZK2</accession>
    <name>A0A2M9JZK2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Lysine transporter LysE</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CG723_12550</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN12187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN12187">
        <property type="protein sequence ID" value="PJN12187"/>
        <property type="gene ID" value="CG723_12550"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006865">
        <property type="term" value="P:amino acid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001123">
        <property type="entry name" value="LeuE-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30086">
        <property type="entry name" value="PTHR30086"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01810">
        <property type="entry name" value="LysE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006324">
        <property type="entry name" value="LeuE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="6"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="41"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="70"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="119"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="152"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="187"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PJN12187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="212" mass="22077" checksum="10655B9856503269" modified="2018-04-25" version="1">MVSSDRLLAFAAMSFLLIVIPGPSVLFVIGRALSQGRRAALTTVVGNTLGAYVLVVAVALGVGAVVERSVLVFTALKLVGAAYLVYLGIKAVRQRRSLHAAFTGDGVAHGSLRTLWEGFAVGVANPKTIVFFAAVLPQFVDRSQGHVTLQMLLLGLVFNVIAVASDSVWGLVAATTRSWFARSPRRLGMVGGVGGLTMIGLGVTVAATGRTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JZV2</accession>
    <name>A0A2M9JZV2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CG723_04725</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000002">
        <property type="protein sequence ID" value="PJN12360.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN12360">
        <property type="protein sequence ID" value="PJN12360"/>
        <property type="gene ID" value="CG723_04725"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PJN12360.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="112" mass="13087" checksum="DBA4D9CB93A61CC0" modified="2018-04-25" version="1">MAATYDFPSDLLAGQEELHQVRAELLTLLKRLPWSVDPLDGFNDDHGWRKRERPASPGWTPDEQAEVEKLRQRERELAVFVTCHRYWKDVSGPDKVDARMYLKRTHEADAPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JZX3</accession>
    <name>A0A2M9JZX3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CG723_04430</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000002">
        <property type="protein sequence ID" value="PJN12307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN12307">
        <property type="protein sequence ID" value="PJN12307"/>
        <property type="gene ID" value="CG723_04430"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PJN12307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="322" mass="34339" checksum="4FE329465D5D69A9" modified="2018-04-25" version="1">MTDSPSPRRPGEPALAALGLSAPSTADADTSPHAFPDGGTWRTEIPSVEGPEALAVVLKEASRLDVPVHRISQGSGVWMLTDAEITEMVESAAERDIELCLFTGPRGTWDTGASVRTDSRGAGLRARGHDAVAGCVEDAVRATELGVKCLLVADEGVLWTLHRAREQGVIPGDTTLKVSALIGPVNPASYAVFERLGADSLNVPSDLTLAHLTEIRRVSAAPMDLYVEAPDDLGGYVRMYEIAELIRRGAPLYLKFGLAKAPAIYPYGAHLRDVTLDTARERVRRGRLALDLLARHGADGGMSPLGSRLPGTLDRFPLTVSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JZX7</accession>
    <name>A0A2M9JZX7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Steroid C27-monooxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_04915</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000002">
        <property type="protein sequence ID" value="PJN12390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN12390">
        <property type="protein sequence ID" value="PJN12390"/>
        <property type="gene ID" value="CG723_04915"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002397">
        <property type="entry name" value="Cyt_P450_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00359">
        <property type="entry name" value="BP450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="SSF48264"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN12390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="414" mass="45823" checksum="92C3AA9D068DBA7E" modified="2018-04-25" version="1">MPCPALPEGFDFTDPDLLQRRVPFPEFAQLRQTEPVRWIAQPTGISGFGDSGYWAVTRHADVKYVSTRPELFSSNLNTAVIRFNESISRDQIEVQKLIMLNMDPPEHTRVRQIVQRGFTPRAIRSLEDALRTRAGSIVETALANAAPDGSFDFVTNVAVELPLQAIAELIGVPQDDRTKIFDWSNKMAAYDDPEYAITEEVGAEAAMEIVSYAMNLAAARKECPAKDIVSQLVAAEDEGNLSSDEFGFFVILLAVAGNETTRNAITHGMHAFLTNPDQWELFKRERPESTAEEIVRWATPVVSFQRTATQDTELGGAQIKKGDRVGIFYSSANHDPEVFDRPDTFDITRDPNPHLGFGGGGPHFCLGKSLATLEINLIFNAVADAMPDLRLTGDPRRLRSAWLNGVKELQVSTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JZX9</accession>
    <name>A0A2M9JZX9_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">UPF0246 protein CG723_05170</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_05170</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0246 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000002">
        <property type="protein sequence ID" value="PJN12435.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN12435">
        <property type="protein sequence ID" value="PJN12435"/>
        <property type="gene ID" value="CG723_05170"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00652">
        <property type="entry name" value="UPF0246"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005583">
        <property type="entry name" value="YaaA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30283">
        <property type="entry name" value="PTHR30283"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03883">
        <property type="entry name" value="H2O2_YaaD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00652"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN12435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="268" mass="28101" checksum="9FBABC4C92F21964" modified="2018-04-25" version="1">MLVLLPPSEGKAPSGRGAPLKPESLSLPGLAGARQAVFDELVELCAADEDKAREVLGLSEGLRGEIAKNVELRTAGARPAGEIYTGVLYDALGLATLDAAAKRRATRSLLVFSGLWGAVRVSDRIPSYRCSMGVKLPGLGALGAHWRKPMAEVLPEAAGDGLVLDLRSSAYTSAWKPKGEVAGRTATVRVLHAQTDPVTGVEKRSVVSHFNKATKGRIVRTLLETGTTPAGPAELVEALRDLGHVVEAQAPAKAGTAWAIDVVVTQIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K084</accession>
    <name>A0A2M9K084_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_05775</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000002">
        <property type="protein sequence ID" value="PJN12541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN12541">
        <property type="protein sequence ID" value="PJN12541"/>
        <property type="gene ID" value="CG723_05775"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="55"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="80"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="119"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="153"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="177"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN12541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="251" mass="27290" checksum="5DA0FFCF2566B92E" modified="2018-04-25" version="1">MGDWWYRNIGEPGKLPLLLALAAFLLTFAVTRTVTRLIRAGRGPFRNVTPGGMHIHHVVPGVILTVIGGFGAVGSGRHGVTASICAVIFGIGAGLVLDEFALILHLADVYWTEQGRQSVEVVVLAAALGLLVLSGFSPLGVNDVSGQEEQGRGTAILTVLVNLLFVVLAMFKGKPRLAVVGVLVPFVALFGAIRLARPGSAWAKRWYRRRPKARARSRLRAYRHDRRWSRMSRGFQDLIGGTPDPERSTPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K092</accession>
    <name>A0A2M9K092_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Adenosylcobinamide kinase</fullName>
            <ecNumber evidence="8">2.7.1.156</ecNumber>
            <ecNumber evidence="9">2.7.7.62</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Adenosylcobinamide-phosphate guanylyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">CG723_05800</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">CB01635</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Catalyzes ATP-dependent phosphorylation of adenosylcobinamide and addition of GMP to adenosylcobinamide phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>adenosylcob(III)inamide + ATP = adenosylcob(III)inamide phosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15769"/>
            <dbReference type="ChEBI" id="CHEBI:2480"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58502"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.156"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>adenosylcob(III)inamide + GTP = adenosylcob(III)inamide phosphate + GDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15765"/>
            <dbReference type="ChEBI" id="CHEBI:2480"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="ChEBI" id="CHEBI:58502"/>
            <dbReference type="EC" id="2.7.1.156"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>adenosylcob(III)inamide phosphate + GTP + H(+) = adenosylcob(III)inamide-GDP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22712"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:58502"/>
            <dbReference type="ChEBI" id="CHEBI:60487"/>
            <dbReference type="EC" id="2.7.7.62"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="6">Cofactor biosynthesis; adenosylcobalamin biosynthesis; adenosylcobalamin from cob(II)yrinate a,c-diamide: step 5/7.</text>
    </comment>
    <comment type="pathway">
        <text evidence="5">Cofactor biosynthesis; adenosylcobalamin biosynthesis; adenosylcobalamin from cob(II)yrinate a,c-diamide: step 6/7.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the CobU/CobP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.156" evidence="8"/>
    <dbReference type="EC" id="2.7.7.62" evidence="9"/>
    <dbReference type="EMBL" id="NNBL01000002">
        <property type="protein sequence ID" value="PJN12545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN12545">
        <property type="protein sequence ID" value="PJN12545"/>
        <property type="gene ID" value="CG723_05800"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00148">
        <property type="reaction ID" value="UER00236"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043752">
        <property type="term" value="F:adenosylcobinamide kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008820">
        <property type="term" value="F:cobinamide phosphate guanylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009236">
        <property type="term" value="P:cobalamin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00544">
        <property type="entry name" value="CobU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003203">
        <property type="entry name" value="Cobinamide_kinase/P_G-Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34848">
        <property type="entry name" value="PTHR34848"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02283">
        <property type="entry name" value="CobU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12 16" id="KW-0418">Kinase</keyword>
    <keyword evidence="11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 16" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00000711"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001522"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00003889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00005159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00007490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00012016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00012523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00029570"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00030571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="PJN12545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="400" mass="41745" checksum="82138545FB4B292D" modified="2018-04-25" version="1">MELTLLGTGAPTGLPRPDCPCAACATALGPVGARAATALLIDGTLLLDLTPGAAFAAARSGHSLSGVRQVLLSHPHDGPPVEVPAGLVSPVRVPDGSELALLTGHRVRALPTDSPGTGYEVTGPDGERLLYLPPGAAPAGFEEAERPYEMVLADIVDRPDAAARLRAVGAIGATTDVLAVHIDHDVPPGPELTRRLAAAGARAVPDGTTLVVGAYEDVPDVPRRTLVLGGARSGKSVEAERRLEAFPGVLYVATGGTRGGDTEWSQRVALHRERRPGSWNTTETCDLVPLLAQDGPPLLIDCLSLWLTYAMDEVQAWDDAEWAGGGERALREKVAALTEAVRNTRRTVVAVSNEVGSGIVPATASGRRYRDELGRLNTAFAAECEQVLLVVAGQVLVLRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K1W8</accession>
    <name>A0A2M9K1W8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_00485</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000001">
        <property type="protein sequence ID" value="PJN13115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN13115">
        <property type="protein sequence ID" value="PJN13115"/>
        <property type="gene ID" value="CG723_00485"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN13115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="78" mass="8410" checksum="CE7EF14E5D0C5356" modified="2018-04-25" version="1">MKIVRRIGVPPRERGSASGATCPDLFELSDGNFAVIGTEATAELDKELPPDAARADYERIVIVSRETLVRAKADIPDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-09-29" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K275</accession>
    <name>A0A2M9K275_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CG723_01180</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000001">
        <property type="protein sequence ID" value="PJN13232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN13232">
        <property type="protein sequence ID" value="PJN13232"/>
        <property type="gene ID" value="CG723_01180"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.620.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009078">
        <property type="entry name" value="Ferritin-like_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012348">
        <property type="entry name" value="RNR-like"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47240">
        <property type="entry name" value="SSF47240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PJN13232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="236" mass="25927" checksum="BA20CCFD3954A066" modified="2018-04-25" version="1">MITRGYAGWVWEFEVERERRAAAGEPAWERGARVDTAIWRSVRRFQIGESGDGANLIAKADRAGDAPYARAVRLFVAEEQNHARLLGLLLGAGGVPPLASHWSDTVFVRLRRLLGLRLELLVLMVAEVVALRYYRALRDGTDDGLTTQVAGAILADEERHVPFHCERLREAFARVPRPVGRLVLLGWRALLLAAALVVACDHGSALRGLGVGRVRFVRDVVASAGPVVRSVLDRAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K2H6</accession>
    <name>A0A2M9K2H6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CG723_01740</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CB01635</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000001">
        <property type="protein sequence ID" value="PJN13328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN13328">
        <property type="protein sequence ID" value="PJN13328"/>
        <property type="gene ID" value="CG723_01740"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="71"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="108"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="140"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="180"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="252"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="72"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PJN13328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="287" mass="30501" checksum="DC0F964706DACA54" modified="2018-04-25" version="1">MEQPNPAAQTLKFVVIVAMIVAVGYPFLLAIGTSLSSKAELAANGGYVLFPSHPTLEAYRVVLSGGVITRAAVVSVGITVVGTALSLLCTIALAYGLSRPRTFAGKPLLLIVVGTFLFTPGIIPNYLVVQELGLLDTYGAMIAPILLNAFNIIVVRAFFQGIPDELHEAARLDGAGELTILCRIVLPLSKAVIAVVGMFYAVTYWNSFFNAMLYINDPDKLPLQVVLRSYVLQGDTFNAKALGVSVLPASTALSMAVLILAVLPIIAVYPFLQKYFVKGVLTGAIKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K2J7</accession>
    <name>A0A2M9K2J7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Radical SAM protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CG723_01830</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000001">
        <property type="protein sequence ID" value="PJN13345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN13345">
        <property type="protein sequence ID" value="PJN13345"/>
        <property type="gene ID" value="CG723_01830"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PJN13345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="439" mass="49126" checksum="CEDDD74187B6E1CA" modified="2018-04-25" version="1">MQSRTALVEDLMERFPHVPREAVFKEDLLRGGVAFDRSALSDNESGDVKPKSYFIFSFDHGTLPELGEAALRRPPEEIILTGGPYDLRRTVVSVRVNPSSPYRVAADEDGMLGLYLDGKRISDVGVPPMPEYYRHKLSNGKSVMEVAPTIQWGYLIYLTVFRVCQYFGAKEECQYCDINHNWRQHKAAGRPYTGVKDVDEVLEALEIIDKYDTTKASTAYTLTGGAITSKLQGRDEADFYGLYAKAIEEHFPGRWIGKVVAQALPKDDVQRFKDYGVQIYHPNYEVWDRRLFELYCPGKERYVGRDEWHKRILDSADVFGARNVIPNFVAGVEMAEPSGFATVDEAIASTTEGLRFFMSHGITPRFTTWCPEPTTPLGKANPQGAPLEYHIRLLEAYRSTMEEYGLSSPPGYGPAGAGRAVFSVSSFMDSLAPEPAPAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K2N7</accession>
    <name>A0A2M9K2N7_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Catalase</fullName>
            <ecNumber evidence="11">1.11.1.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CG723_02115</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">CB01635</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>2 H2O2 = 2 H2O + O2</text>
            <dbReference type="Rhea" id="RHEA:20309"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="EC" id="1.11.1.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the catalase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.11.1.6" evidence="11"/>
    <dbReference type="EMBL" id="NNBL01000001">
        <property type="protein sequence ID" value="PJN13394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN13394">
        <property type="protein sequence ID" value="PJN13394"/>
        <property type="gene ID" value="CG723_02115"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004096">
        <property type="term" value="F:catalase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042744">
        <property type="term" value="P:hydrogen peroxide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08156">
        <property type="entry name" value="catalase_clade_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018028">
        <property type="entry name" value="Catalase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040333">
        <property type="entry name" value="Catalase_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024708">
        <property type="entry name" value="Catalase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024711">
        <property type="entry name" value="Catalase_clade1/3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011614">
        <property type="entry name" value="Catalase_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002226">
        <property type="entry name" value="Catalase_haem_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010582">
        <property type="entry name" value="Catalase_immune_responsive"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020835">
        <property type="entry name" value="Catalase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11465">
        <property type="entry name" value="PTHR11465"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00199">
        <property type="entry name" value="Catalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06628">
        <property type="entry name" value="Catalase-rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038928">
        <property type="entry name" value="Catalase_clade1-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00067">
        <property type="entry name" value="CATALASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01060">
        <property type="entry name" value="Catalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56634">
        <property type="entry name" value="SSF56634"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00437">
        <property type="entry name" value="CATALASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00438">
        <property type="entry name" value="CATALASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51402">
        <property type="entry name" value="CATALASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 10 11" id="KW-0349">Heme</keyword>
    <keyword evidence="8 11" id="KW-0376">Hydrogen peroxide</keyword>
    <keyword evidence="7 10 11" id="KW-0408">Iron</keyword>
    <keyword evidence="5 10 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3 11" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Catalase" evidence="13">
        <location>
            <begin position="7"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="363"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="54"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="127"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="10">
        <location>
            <position position="337"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000720"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR038928-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR038928-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM01060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="PJN13394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="485" mass="54055" checksum="CABEE9977635A5DA" modified="2018-04-25" version="1">MSKRVLTTESGAPVADNQNSATAGVGGPLLLQDQHLLEKLARFNRERIPERVVHARGSGAYGYFEVTDDVTGFTHADFLSTVGKRTETFIRFSTVADNLGGADAVRDPRGFALKFYTEEGNYDLVGNNTPVFFIKDPIKFPDFIHSQKRDPFTGKQEADNVWDFWAHAPEATHQITWLMGDRGIPASYRHMNGYGSHTYQWTNAEGEAFFVKYHFKTNQGIRCLSSEQGAEIAGKDANSHQTDLLQAIERGVNPSWTLYVQLMPVAEADDYRFNPFDLTKVWPHKDYPLQRVGRLVLDRNPDNVFAEVEQAAFSPNNFVPGIGPSPDKMLQGRLFAYADAHRYRLGVNHTQLAVNAPKATDADNYGRDGLMASNAYGRDRKNYEPNSYDGPAETGRPLSAPLAVAGYTGTHEAPAHTKDDDFFQAGELFRLMSDDEKSRLIANIAGGLSQVSRDDVIEKNLAHFHAADAEYGKRVEEAVRALRED</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K2P3</accession>
    <name>A0A2M9K2P3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_02100</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000001">
        <property type="protein sequence ID" value="PJN13391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN13391">
        <property type="protein sequence ID" value="PJN13391"/>
        <property type="gene ID" value="CG723_02100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="87"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN13391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="266" mass="28294" checksum="A20028BDA7F53B94" modified="2018-04-25" version="1">MAQNVPVRCPACRREQVYAPPVYPCSCGAPVVPPLRRGAPAEPVTHRTWLDDWVTVRCAACGRRDRWPRPEIGCACGTVLRIPVEGDPAPSHDASPDSDVAGGATWPGPAVPPTTDGPDQAGPTRPGPAHIPLPPTAPVPRPAFRPVAIRTARDAVTAVALYLRWLGYRDIRRADQRPSSGIGLAARGVVAQVEPSVRPATLRDVECLWLTGMTESAVCVYFSLAGYDEDARTRADELGVPLFVLDLAGMPQPVNNPADELIAAGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K3R0</accession>
    <name>A0A2M9K3R0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">4-hydroxyphenyl-beta-ketoacyl-CoA hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_01575</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000001">
        <property type="protein sequence ID" value="PJN13752.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN13752">
        <property type="protein sequence ID" value="PJN13752"/>
        <property type="gene ID" value="CG723_01575"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016831">
        <property type="term" value="F:carboxy-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032465">
        <property type="entry name" value="ACMSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21240">
        <property type="entry name" value="PTHR21240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04909">
        <property type="entry name" value="Amidohydro_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydro-rel" evidence="2">
        <location>
            <begin position="9"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN13752.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="290" mass="31803" checksum="2F9D114C30C25330" modified="2018-04-25" version="1">MDVAALTAIDVHTHAEVSSKGRASLDDELNAASSAYFKVEGNRKPTLEETAAYYRERRMAAVIFTVDAESATGTEPVPNEEVAEAAHANPDVLIPFASIDPFRGRAGIRQARRLVEEYGVRGFKFHPSIQGFFPNDRMAYGLYEVIEETGAVALFHTGQTGIGAGVPGGGGIRLKYSNPMHVDDVAADFPHLKIILAHPSFPWQDEALAVATHKPGVHIDLSGWSPKYFPQQLVQYANTLLKDKVLFGSDYPVLTPDRWLADFAKLPIKDEVRPKILKENAARLLGLTKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K3W7</accession>
    <name>A0A2M9K3W7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">4-carboxymuconolactone decarboxylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">pcaC</name>
        <name evidence="3" type="ORF">CG723_02435</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000001">
        <property type="protein sequence ID" value="PJN13770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN13770">
        <property type="protein sequence ID" value="PJN13770"/>
        <property type="gene ID" value="CG723_02435"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051920">
        <property type="term" value="F:peroxiredoxin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029032">
        <property type="entry name" value="AhpD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003779">
        <property type="entry name" value="CMD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012788">
        <property type="entry name" value="Decarb_PcaC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02627">
        <property type="entry name" value="CMD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00111">
        <property type="entry name" value="ABHYDROLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69118">
        <property type="entry name" value="SSF69118"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02425">
        <property type="entry name" value="decarb_PcaC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="20"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="domain" description="CMD" evidence="2">
        <location>
            <begin position="337"/>
            <end position="419"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02627"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN13770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="430" mass="45929" checksum="3EB8D298626345CC" modified="2018-04-25" version="1">MSETPKNTLQYRFDGPEDAPVLILGPSLGTTWHMWDRQVPELARQWRVFRFDLPGHGGAPAHPAGSVADLAARLLATLDELGVQRFGYAGCSLGGAIGAELALRHPQRVASLALIAASPRFGTADEFRQRGVIVRSNGLDPIARTSPEHWFTSGFAAAQPAITDWAVQMVRTTDPGCYIAACEALASFDVRAELGSIGVPTLVLVGSDDQVTGPAQARTLVAGIPDARLAVVPAASHLAPVEQPAAVTDLLVRHFSTAWQPAYETGQHAIPAAPVKPVLAPPPPPVAPVAEIGPTEAQPEAEVRPDRHDIGLKVRREVLGDAHVDRALASADAFSGDFQEFLTRYAWGEIWSRPGLDRRMRSCVTLTALVAGGHLEELAFHTRAALRNGLTADEIKEVLLQAAVYCGVPAVNSAFKVAQAVIREETTPQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K3Y4</accession>
    <name>A0A2M9K3Y4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Type VII secretion protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_03330</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000001">
        <property type="protein sequence ID" value="PJN13790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN13790">
        <property type="protein sequence ID" value="PJN13790"/>
        <property type="gene ID" value="CG723_03330"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002586">
        <property type="entry name" value="CobQ/CobB/MinD/ParA_Nub-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01656">
        <property type="entry name" value="CbiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CbiA" evidence="2">
        <location>
            <begin position="53"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN13790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="292" mass="30605" checksum="AB4CA3A303ABEFE8" modified="2018-04-25" version="1">MAGALGRAQRGDTMARRTGHSLRRLASSAAPGVSEETRLARAVQQPVANGRVVAVTSIRGGVGKTTVSALLARTLNHYRHDPVLALEADAALGTLPVRLGAESVRWSCPDLAQILKPSMRLTDVTGYLVPVTDGGWLLPASQGRVGAPLDIRTYRTVSLALRRYFAVTVVDCETLPGEVARTAMDTAHARVVVAPMTAEGVGGTRVVLDWLAQLPKAALASTVVALTSSAPDMTLDLKAATAHLRETGVAVVHLPYDRHLAAGGPIRTALLSEATRRAATGLAAEAVQRAAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JEM3</accession>
    <name>A0A2M9JEM3_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CG723_45250</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CB01635</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="NNBL01000052">
        <property type="protein sequence ID" value="PJN05344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN05344">
        <property type="protein sequence ID" value="PJN05344"/>
        <property type="gene ID" value="CG723_45250"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025666">
        <property type="entry name" value="PQQ-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018391">
        <property type="entry name" value="PQQ_beta_propeller_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002372">
        <property type="entry name" value="PQQ_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_supfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13360">
        <property type="entry name" value="PQQ_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13570">
        <property type="entry name" value="PQQ_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00564">
        <property type="entry name" value="PQQ"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="SSF50998"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="8">
        <location>
            <begin position="10"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="266"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="39"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PJN05344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="691" mass="72659" checksum="DC6F42F97624F7C4" modified="2018-04-25" version="1">MAVRVLGGRYELVAFVGRGGMGEVWEGRDRVIERRVAVKLLPHDRRDASGAELFYREAKTAGGLNHAGVVTVFDMGLDPNDGTLYLVMEFLAGRDLDTVLRQDGPPEVATAVEWAAQTAAALGVAHAAGIVHRDLKPANLMLGLDGRVKILDFGIARYLASTHRSSKVIGTLAYMPPERFGEFPGDARSDLYSLGCVLHELLTGQPLFRAGDLVAMMAAHLHTTPLPPGQIRSGVPAALDDLVLALLAKNPDHRPASAAEVHHRLRELPTSTPGSVTDTSLPDAAPPAGAGPATPGGLTTIPRNHTPHQDPTATAPAPEHVPGPAAARTRPRRITRRTALGLGIGAAATAGITAALTLFDDGSRYARLRWRQPIGRLINSSPTVVDGVVYVGSDDNKMHALDARTGNPKWTYATGGNVDSLPTVVDGVVYFGSDDGSVYAVDAGTGNRAWAFPASINHNPVDESPAVAEGIVYIGSSNHVHALDATTGAVKWDFERPGTDWGFSSAAVVDGVVYFGGATNVYALDAATGKQKWASNPGTDRGFSSPVVTDGIVYTGNRKDVYALDAATGKQKWAFTIDSDFFSLPAVVDGVVYFGSNNSVYALDAATGAEKWIFTTGGSVQQPPVVVEGVLYVGSYDKNMYALDAATGKQRWAFTTGGGVSATPAVAERVVYVGSADGNMYALDATGKDPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JEM6</accession>
    <name>A0A2M9JEM6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_45345</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000053">
        <property type="protein sequence ID" value="PJN05341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN05341">
        <property type="protein sequence ID" value="PJN05341"/>
        <property type="gene ID" value="CG723_45345"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="52"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="76"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="105"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="239"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="261"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="286"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="313"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN05341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="444" mass="47329" checksum="17DE1DE3495CADA0" modified="2018-04-25" version="1">MPAFAHALGWDEAVYVSQYDPRVPAAFFSAPRSRGISFLTAPFIAVTPSVPVLRIALTLLSSAALYAAFRVWRPVVGARATALAALLFAGLWITQISGPQAMPNLWVAFGSVAATGWFLRALIRREPRANRWLAGCVAVTALFRAPDAVWLALPLIATALFRGRRTLPYLVGGLATGLAQWVAEAYIRFGSVQERLHVSSATEGDMGLHLNFDNAWASLNGPLLCRPCTATLHSPGLTLWWLALPALAAAALAYAVRERRLLAAALPVAVAAALAVPYLLMIDYSAPRFLLPAYALLALPVASLVTRLTSRRALFLVGLIVAAQFASQASVLTEVTAATATTNQRYRAAADGLRTLGLRPPCLVSGPRALPIAYDAGCASAQIDGNNVSTTVAGILGRAAKVPTAVLTEKGQRPPHYARDWTPYPLHHTRGWTAWLAPAVPQGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JF44</accession>
    <name>A0A2M9JF44_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Response regulatory domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CG723_45170</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000051">
        <property type="protein sequence ID" value="PJN05377.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN05377">
        <property type="protein sequence ID" value="PJN05377"/>
        <property type="gene ID" value="CG723_45170"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="3">
        <location>
            <begin position="47"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PJN05377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="439" mass="47982" checksum="20A6DD03073AF7D6" modified="2018-04-25" version="1">MTSEPRRRRTHDRPGPLGHRHRLAHHTADRPYHNNGGPVTDEVTGARILVADDQTDVARTLCSPLRKAGAQLRFVPDGQTALAEIAIRPFDLIIVDMKMPPEEWGGLWLLRRLSLDGWRIPTLVLSGEGSKQQVIEALRLGSADWIDKDAAGEELLGRCTQILRDRLEPSLELASTQLPTPLAFRFARYARTTDPEKQVTEGLHTLEAVLRFAAALGLSNPAPAPLQGISPERLAQPSMGTWFTLCTALAQTPGCCTPFTEILSWLMPGRADRQPVQDLVKLRNDIAHGRATATPAHRDSLDLLLRRFAHRAASSWRASLAVPTSMTYDGSTYTLDVLTFTGAGKPSPGTVRTEHPQVTGRMLLLTGHAPPLCLSPWLVAQATHPSGTPRCLQFDGLQRARNSPDSATPLKYAKADDGEDTTTAGHPGGTWQALAAWLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JF65</accession>
    <name>A0A2M9JF65_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CG723_44245</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000046">
        <property type="protein sequence ID" value="PJN05530.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN05530">
        <property type="protein sequence ID" value="PJN05530"/>
        <property type="gene ID" value="CG723_44245"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PJN05530.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="139" mass="15771" checksum="DDF3E9E1C540239B" modified="2018-04-25" version="1">MICPPDRGYDFSGSHTYYRDMEPRSGGDSGTTISITFHKGKTTTSTVGGAVSGEAKVVFVKASAEFDYHFAWQWTNSSTYTWSWKVPNTMRHGYLHAGVKARYTKWNYNQTEPNCEIKVLRKGSARLVYNGRETWHGKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JFC8</accession>
    <name>A0A2M9JFC8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_44010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000045">
        <property type="protein sequence ID" value="PJN05590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN05590">
        <property type="protein sequence ID" value="PJN05590"/>
        <property type="gene ID" value="CG723_44010"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="29"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN05590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="47" mass="5459" checksum="FAA29B32EE956E98" modified="2018-04-25" version="1">MNKQRNTIERAINRLKQHRAVATRYDKRGYVFLGTATAAALVIWLRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-06-02" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JFX7</accession>
    <name>A0A2M9JFX7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_42880</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000041">
        <property type="protein sequence ID" value="PJN05778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN05778">
        <property type="protein sequence ID" value="PJN05778"/>
        <property type="gene ID" value="CG723_42880"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="43"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN05778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="179" mass="19036" checksum="7E888F7EF221B0D5" modified="2018-04-25" version="1">MSLPGADELFRTTGGMGLQASSPRRPVNGEARVPAPAGESDAVAAEEKQRGEGGESAEHAAADDESGESRSRATEGDQPAGRRPPQGQEGSASAGSSRKRSRAPANRRPSGRERHDEKITVYVSAEELMDLEHARLVLRGEHGLAVDRGRIVREAVAVVLADLESRGDASILVRRLRGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-05-25" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JG28</accession>
    <name>A0A2M9JG28_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alcohol dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_42650</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000040">
        <property type="protein sequence ID" value="PJN05835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN05835">
        <property type="protein sequence ID" value="PJN05835"/>
        <property type="gene ID" value="CG723_42650"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NADP_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="SSF51430"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldo_ket_red" evidence="1">
        <location>
            <begin position="17"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN05835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="314" mass="33325" checksum="78FEC80DD84E406E" modified="2018-04-25" version="1">MTSLRKLGSSDLEVFPLSLGGNVFGWTADEAQSFAVLDGYVAAGGNFVDTADAYSSWVPGNKGGESETVIGKWLAARGNRSDVVIATKVGAHPDFKGLSANTIKSAADESLRRLGTDYIDLYYTHFDDPSVPVEEIISALDELVKSGKVRAIAASNLTPERLQESLDFSDREGLARYAALQPHYNLVSRDTYEGRLQEVASRSGLAAVPYYALASGFLTGKYRPGTEVDSPRAAGAGRHLQTERGVRVLKALDEVAQAHGAEVATVALAWLASRPTVAAPIASARTVEQLPALVAVADLELTDAELSKLTEASA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JGA0</accession>
    <name>A0A2M9JGA0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Cytoplasmic protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CG723_42250</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000039">
        <property type="protein sequence ID" value="PJN05862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN05862">
        <property type="protein sequence ID" value="PJN05862"/>
        <property type="gene ID" value="CG723_42250"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009351">
        <property type="entry name" value="YcaQ-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06224">
        <property type="entry name" value="HTH_42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PJN05862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="392" mass="43660" checksum="9F91A49370FB5727" modified="2018-04-25" version="1">MTTTPRPAAELSADEARRIALRAQGFLGAPDRKGGVRGVLRHLGAVQLDTISVLARSHELIPYARLGAVGRRTVEDAYWTPGTAGAPHAFEYWSHAACILPIEEWPHFAFRRRAYRTRPHWHHDLPDGAYEQVIKQLRTEGPLTATELGGAKNKGEWWDWSEAKVAVERALMYGEVVCTQRRSWKRVYDLAERAVPAELLHDDLDDRECLRRLVRLAGQSLGIGTRSDIADYHRLKHEQFDAVVEDAGLVPVTVQGWGKPAWADPEALDTAPRGRHRTTLLSPFDSLIWERPRTERIFGFTHRLEAYVPKPKRVHGYFAMPVLAGGHLVGRVDPARDGSTLVARQVSLDGPKAVPAVAQALREAAEWVGCDAVRIERVDAPNLKPALVTALG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JGB2</accession>
    <name>A0A2M9JGB2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_42315</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000039">
        <property type="protein sequence ID" value="PJN05872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN05872">
        <property type="protein sequence ID" value="PJN05872"/>
        <property type="gene ID" value="CG723_42315"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_2-like" evidence="1">
        <location>
            <begin position="14"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN05872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="563" mass="62564" checksum="392008DC878D5B57" modified="2018-04-25" version="1">MTTPTRTITPDVTVTVIVYNDAGRLPRAVASVLAQTHGNIEVVISDDHSTDATPEVARRLAAADPRVRYLRLPENSGGCSAPRNRALDIARAPYLMFLDSDDELPPESVELLLAAHREREIDFAMGAVERIRVDTGRTSTWMPHLVSERRTVDGIDAEPGLFFEHLSTSKMYKREFLDRNQLRFPEGIHYEDQLFSAQAYCLAKSFTVIPEPVYRWYIAPFVEADAASISNQRHKLTNVRDRVHVQELIDDFLASGGHTGVREDKDYKFLKHDFRMYAGDLPYRDYAWLAGFAEIVNPYLATLSPGAYARLPRPERVVLQLVRDGRLSDARLAARGLGHVVAPRETATDASGAVYWGAVVPSSDEARAELDLSDQELYSRPFPSAQFRHEITRIERGPGAGVDLSVRTYDPGLRLAVGPHVASLVVAPGRHRMTTRLRLDPVRPGVFEGRVRLDLAAAPLPVHGFDGMRHPLLQLQDHGLRNTSVLLAPLDFPALTARVGYRSGAAPHRVTLEPEGRGGGRLQIRWEPAGLTARVTHPVARRLATASDGRVRNAVRLVRSALR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JGD5</accession>
    <name>A0A2M9JGD5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CG723_42175</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000038">
        <property type="protein sequence ID" value="PJN05938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN05938">
        <property type="protein sequence ID" value="PJN05938"/>
        <property type="gene ID" value="CG723_42175"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004315">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017000">
        <property type="term" value="P:antibiotic biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901362">
        <property type="term" value="P:organic cyclic compound biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030639">
        <property type="term" value="P:polyketide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018201">
        <property type="entry name" value="Ketoacyl_synth_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032821">
        <property type="entry name" value="PKS_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020807">
        <property type="entry name" value="PKS_dehydratase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042104">
        <property type="entry name" value="PKS_dehydratase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013968">
        <property type="entry name" value="PKS_KR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16197">
        <property type="entry name" value="KAsynt_C_assoc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02801">
        <property type="entry name" value="Ketoacyl-synt_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08659">
        <property type="entry name" value="KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14765">
        <property type="entry name" value="PS-DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00826">
        <property type="entry name" value="PKS_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00825">
        <property type="entry name" value="PKS_KS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="SSF47336"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00606">
        <property type="entry name" value="B_KETOACYL_SYNTHASE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="4" id="KW-0045">Antibiotic biosynthesis</keyword>
    <keyword evidence="1 6" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Carrier" evidence="8">
        <location>
            <begin position="1309"/>
            <end position="1382"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="8">
        <location>
            <begin position="2143"/>
            <end position="2217"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="8">
        <location>
            <begin position="2254"/>
            <end position="2331"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1274"/>
            <end position="1298"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="2046"/>
            <end position="2141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="2220"/>
            <end position="2253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="1277"/>
            <end position="1295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="2056"/>
            <end position="2082"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="2108"/>
            <end position="2132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="2228"/>
            <end position="2245"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="6">
        <location>
            <position position="1343"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="6">
        <location>
            <position position="2177"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="6">
        <location>
            <position position="2291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PJN05938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="2381" mass="248041" checksum="DEBFCCC837C29504" modified="2018-04-25" version="1">MTHDDPGIDPNAIAVVGMACRFGPATSAGRLWELLEEGKTGIRRYTEAELIGLGHDRATVAREGFVPAGVVLEDADAFDAEFFGYSAQHAEWLDPQQRLLLEVAWHGLEDAGFAPDRTGLRTAAYVSVGQPTQPPVAITDLDAAGMIRFSSSDKDFAATRVSYKLGLTGPSLTVQTACSSGLVGVHLAAESLLGQECDLAVVAAASLHFPQAGYLAAPGMILSPTGECRPFDDTADGTVFGNGGGALVLRRLADAVRDGDPVRAVLRGSAVNNDGSRKMDYHAPSPEGQEAVIREALAVAGTDPHSVGYLETHGTGTPLGDPVEFAALERVYGGERPHPAAVGSVKAVLGHLNTAAGIAGVAKAVLALENGTVPLQAPFSEPNRALRGAGGLRVAERGVVEGGWPVPQGPRRAAVSSFGIGGTNAHVVLEQAPPLAESAADAGGGVRWTVLSAHTETALRELAGDLAGAVAGRSLADVAHTLHTGRSRRRIRAVLGAATVTELSYALRELAAGGPLVTDAAPDGYRAWAAGEGDLPEQDATGARRVRLPGYPFARTVWPRPGAAPARTVRPEDPVAADHVVAGRPVLPAAAQLDLALTAARRTAPATAGLADVAFHRPVEVTGPVTLRAVVEGDAVRILSDTAHAEARLLAGPPAAPERLDPAALRAAYPDSAEPADLYRYFADHGVVYGPAFQVLRELRHGSEGALARVVANGPSGGDTLCPYVLDGALQTVIGCVLREDLGGETFIPFAVDTLTLHAPLPREAWVRVRPVRLAGGGRRVRKYDVTVTGADGTAVLTLAGLALRPVPRDAAQATPVVPVLPSGVHLFAPATVPFDGGPGGEPAPLVVIGDAPLAGAAVRLADPEDAERAAALGDELVARLGEDSRPPVVVWPLAGAGTGSASDALRVLALLRALLRPLSRRGARIVVPFPAGALDDDAAVTGHGIAALGRSLAGENPRFELTAVALDAEAGPDALESAVRAAVAQAPAARWLGVARDSTLTTSVLRHCDAPAAGRAPFRTGGRYWINGMGGLAAHLARHLIDTRAAHVVLTGRSAAEGERGAEIARLAERAARSGGSVTYHRLDSADPAAVRALAHRLNAEGPVHGVLHCAGVLRDAYVLRKDIDDAAAVLAAKLTAATALDAATAGWELDFFVVYSSVSGALGSPGQADYAFANAAVDEFVTRRARLVNSASRTGRSLAVSWPYWADGGMRTGPDAEQVLDGLGMRPMPSATGITVLEALLGAPERDGEESAPVVLYGDLDRLRESFPLLAQDPVPAHSPTPTPTPTPPTTPAEQAALTPRSAPAAGLLEERLRAVVAEATRTPVDQVWPDRPFDDLGIDSLLAIRVVELLESDFGRLSKTLLFECRTVAELAEHLVEEFPERCADLIGPTEPADVPVTEEPPASSTALLDVSLRGATGDKDARPGAPDPHAGIDPRAVAIIGVAGRFPEADGLDELWANLLAGRDSITEVPRERWDAEALYDTDKTRVDRTYTKWGGFVRGVENFDAPLFSISPREAGTVDPQARLFLESCWAALDDAGYTPDTLVTADDPVHRKDVGVFVGAMYGEYQLHEAEERLRGNHVLANSAYWSIANRVSYYFDFQGPSTAVDTACSSALTAIHLAVESLRAGSSKVAIAGGVNVLIHPNKYFMLGQGRFAASDGRCRSFGAGGDGYVPGEGVGAFVLKPLADAVRDGDHIHGVIRGTSANHGGRTNGYTVPNPRAQADLVTKALRDAGLTADGLDYVEAHGTGTSLGDPIEIRGLASAFARDGMKGAGDLPIGSVKSNVGHLESAAGAVALAKVLLQMRHRTLVPSLHATPANPEIDFDGVPFTVQQGVAPWTTRDGSDRPLRAGISSFGAGGGNAHIVVEGPPPRAPRAPEQPGPVVVFLSARTDEALAAYAAALRDDLTAAGERGTQIPLADVAYTFAAGRADLERRAAVAAGSMPELLSGLAAVAAGRPRPWRRTEVTADDPVRVWLDGGRIDRVVVSAAGAQARRAPLPHYPFERVRCWYDLQIERLHRQGQGTAGAEPALDRGHLRDFGREDRAAPASRPKPSAAPTPEPEPTPAVPSLPRPVPAKNTTTPTPQETSSMTRDRKISLRPLDTAPAPAPVPAPAPVRAPAPAAAAPAPVAPPHDGAHQDRVAEEVGEVLAGVLYMDPADLDPEQTFQTLGVDSILSVEFVALVNARFGTDIKATELYDHPTPSAFARQVAAKAAGDKPVRPAAQQAVPAPPARPQPAQAPAPKAAPADDDRGAAVLETLREQLAETLYCDVWDIDVHATFNTLGLDSILGVEFVAFLNNAYGLDEKAGVLYDHPSLTALAAHIAARGAAPAPATTAPATTGAAAGQISAADLDALLGAVRDNRLTVEQALALLPQHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JGG5</accession>
    <name>A0A2M9JGG5_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF305 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_41720</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000037">
        <property type="protein sequence ID" value="PJN05968.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN05968">
        <property type="protein sequence ID" value="PJN05968"/>
        <property type="gene ID" value="CG723_41720"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005183">
        <property type="entry name" value="DUF305"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012347">
        <property type="entry name" value="Ferritin-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03713">
        <property type="entry name" value="DUF305"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF305" evidence="1">
        <location>
            <begin position="6"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN05968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="96" mass="10191" checksum="3003683AD29F57AB" modified="2018-04-25" version="1">MPPPSAENRREGVLMPGTASRAELDTLRGARGKRADEVFLWLMIAHHRGGVHMARAVAGHGAPVAVERLARTMVAGQQAEIALMESLLKASGGGPW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JH04</accession>
    <name>A0A2M9JH04_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_40505</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000034">
        <property type="protein sequence ID" value="PJN06160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN06160">
        <property type="protein sequence ID" value="PJN06160"/>
        <property type="gene ID" value="CG723_40505"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014993644" evidence="2">
        <location>
            <begin position="47"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="62"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="105"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="153"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="203"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="234"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="290"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="321"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="372"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="407"/>
            <end position="430"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN06160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="446" mass="46537" checksum="E5B947663BB50261" modified="2018-04-25" version="1">MMRLVLSDVRMQASMWLWTLLCAAVGAACSAGSVIAMFTAVSAAQAAGDARMVSASIALGGNIVFFTVLAAVGIVASTVGLTLTTQRREHALWVILGIPRHRVRFILRTELVVLGMMAGALAVPLAPLVASVALTQWTTTGLDLHGAMVGFQFWHIGASVLSGVVPCLLGGWGVTRRAAKTSEMRAFRDLSDPPARPGVARSILAFCLLAGVVGMWIPGLGIELEGGIEQRTAFAFAGNLFLICLLLLMGPWVLTPLMKFWTALVPSRGVAWHLAVQSCRTRAARSVTTVLPFALSLSLVGLFTVMGNVMPGSTAGLNDVLVVLGWVFVASWVGGLAVIALVGRERTRDSAIVTVAGARPGVLTRSTIYEGVIYAGTAIIFGAISIAVTSVSIAVGAKISVVQVLDGLPWATLGGLAAVTLVTTCLALALQAVRVSRTVATRALRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-09-29" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JH40</accession>
    <name>A0A2M9JH40_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_40750</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000034">
        <property type="protein sequence ID" value="PJN06198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN06198">
        <property type="protein sequence ID" value="PJN06198"/>
        <property type="gene ID" value="CG723_40750"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029030">
        <property type="entry name" value="Caspase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011044">
        <property type="entry name" value="Quino_amine_DH_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037783">
        <property type="entry name" value="Taf5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19879">
        <property type="entry name" value="PTHR19879"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50969">
        <property type="entry name" value="SSF50969"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="SSF50978"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52129">
        <property type="entry name" value="SSF52129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="1">
        <location>
            <begin position="1035"/>
            <end position="1058"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="58"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN06198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="1672" mass="179274" checksum="4F5E6236A2312669" modified="2018-04-25" version="1">MVRPSAGAEGRAGSAGHAGTATRHDGGCRPCAGAAAAARRYDGRRRGSRGGLAAEPPWKPHGDDHQARWHAGRRHCGEGARPHGTGRERAGPAGRRGTRGALGSARGGRRCGGRGGRGATVTSSAAPEGGGPSAADAYGVVSPAVEELSVSDLAGPHCRAVVIGTGQHPEGAALHDLPSAVRSACDLATVLSAVCGMAEDRIDLMVDPATAAEVLATVDSAARRAEGGVLLVFFAGHGLLGPGDQLYLATAAVTGPGDTAHAVPYTEIRNRLSEAPLRPVVVLDCCLSGLADVPERASRADPYATARPDGSFLLASAMHYAASFAPEGERHTTFTGELLRLLREGDPGAPRWFRLTDLYRHLDRRFQGTPARPHASSTGRIGDLRVARNAHAAAVIPEQDAAEDLSNADSDSPYPGMRPYLPDQSHLFHGREQLTRDLVARLRQPGPVVLVGPSGVGKSSLLRAGLCPAADEAGLGPVLLLEGLGERPFRTLAQRWADAVDRPFHEVERALGEGRFVPPAGAAARRPGVLVVDQAEEAFTLCTDLEERALFTRALAGGTEGDAEDADGRAGTPHIVIGMRADHYEHCLRDETLAPLVQQGQFNVPAMTQEELRRAIEGPARQAGLTLEDGLADVLLRDLGQARTGRQDAVALPFLAHALQETWARRRRGRLTFAGYYATGGLWASVSHSANAIHDSLPADEQPALRELLLRLVQVVDRSGSIVRRRVPLSDLDHGVELLGRLAEARLVVLDDEHAQLSHDALLHAWPLLREWIDEDLAGLLLQQRLGTAADVWAESGRRRDLLYTGRLLQSAEEVRVSGARIVPLRPVEREFVAAGVRRRSIWRRGVAAAVCLLLVVTGLAVYFGLDSRAAQRESESRETRLVAQQLAARADSLREADPQTAMRLSLAAYHTAETSESRSSLYASYMTLTPVDLPVPERSAVLALAYRPDGAVLAASHRAGKEGGQVQLWDLSRRGVPRMAHAIPTTGSASIAYQPGGTVLAVHSPTRLELWDTADPDEPQLLAGRQVPHEVAYTLAFSPDGRTLAAGGDSGRLRLWDASRPDAPEIRFDRDVADSALKSLAYSGSGAYLVTGNGVRPAKDGERPAQVRVWDTRDPLRPVLRDTAETKSLASVAFHPRRPLVATAGAAGLAYWVVEGGPAEARLRHVEQGKDSYGPQWDGTGNEIVSSMAFNKDGTLLAGAMSSGSRTLVRQVGPDDNETLYSGDATTDELTTSEEAQAVAYSPDGVVLAAGDVSGAIRLWPNRPAAPAVVGKLSMEQPGESVLSKDGRLLLTDTPALDPVQGSPTVRVWDVRKPSAPRVRFTVPRGWEANSFLPGDGATALLTHQWREGSDRHTFRFWVFGRSGAPKQGRPFHVEAQDLMTRTSTDGKLLAAGTSTGGVELWDVSDPLLPVRRSVSDMELSGDLFSTGRLWFTGDKALGTVANGVDIRLWDVSDPTRPRLSRTIEGAAADGGASYLYQSKILLTEEAGQYLRLWDMKDPAHPKKAGKIPGASAAGYPVGTDQIVTVLKDGNVHFWDVRDPRKPEVDEDRTLRIDQLPDDVRVTPDGKNVLTSNPYRLWDLDDDGRWSTPSTVTLEGASRVVVSNAVDGGQSYMAVEPKQPGPGGRSQTYVLPYDTDGIYEELCEGSPLSVDKKQWTSLFPHLMDKYRNACE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-09-29" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JH81</accession>
    <name>A0A2M9JH81_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CG723_40135</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CB01635</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000033">
        <property type="protein sequence ID" value="PJN06231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN06231">
        <property type="protein sequence ID" value="PJN06231"/>
        <property type="gene ID" value="CG723_40135"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="21"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="55"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="89"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="113"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="152"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="178"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="226"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="263"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="296"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="320"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="351"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="375"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="7">
        <location>
            <begin position="20"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="198"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PJN06231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="405" mass="40917" checksum="08BBF8A8FE64DCDE" modified="2018-04-25" version="1">MPTLNKLRAVKDDSPRTASLTRLRIALTIFFALDGFIFAGWVVRIPAVKEQTGASASTLGLALLGVSAGAVITMMLTGRLCRRFGSHPVTVVSGVLLALSVALPPLTHSALTLGLVLLVFGAAYGGINVAMNSAAVDLVAALRRPVMPSFHAAFSLGGMLGAGLGGLVAGHVSPTRHLLALTVVGLLVTAAVGPTLLRHDAPTAPDDSSRTRSEPASASERPAGRVRGLVLVFGLIALCTAYGEGALADWGALHLEEDLHAHPGVAAAGYSCFALAMTIGRIGGTTLLERLGRTRTLVFGGATGAVGMLLGSLAPTVWLALLGFAVTGLGLANIFPVAVERAGALAGPTGVAAASTLGYGGMLLGPPMIGFMADWFSLPAALTSVAVLAGVAALIGFATRRAAVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JHH1</accession>
    <name>A0A2M9JHH1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CG723_39990</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CB01635</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Antibiotic biosynthesis.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000032">
        <property type="protein sequence ID" value="PJN06326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN06326">
        <property type="protein sequence ID" value="PJN06326"/>
        <property type="gene ID" value="CG723_39990"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00139">
        <property type="reaction ID" value="UER00341"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017000">
        <property type="term" value="P:antibiotic biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008610">
        <property type="term" value="P:lipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901362">
        <property type="term" value="P:organic cyclic compound biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030639">
        <property type="term" value="P:polyketide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.109.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010071">
        <property type="entry name" value="AA_adenyl_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001242">
        <property type="entry name" value="Condensatn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029479">
        <property type="entry name" value="Nitroreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000415">
        <property type="entry name" value="Nitroreductase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00668">
        <property type="entry name" value="Condensation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02801">
        <property type="entry name" value="Ketoacyl-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00881">
        <property type="entry name" value="Nitroreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00825">
        <property type="entry name" value="PKS_KS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="SSF47336"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55469">
        <property type="entry name" value="SSF55469"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01733">
        <property type="entry name" value="AA-adenyl-dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 5" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Carrier" evidence="7">
        <location>
            <begin position="1430"/>
            <end position="1505"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="7">
        <location>
            <begin position="1525"/>
            <end position="1600"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="868"/>
            <end position="904"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1506"/>
            <end position="1527"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1591"/>
            <end position="1615"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="870"/>
            <end position="898"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="5">
        <location>
            <position position="1465"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="5">
        <location>
            <position position="1560"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="2337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PJN06326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="2337" mass="246416" checksum="C9DDC1EA017B85F0" modified="2018-04-25" version="1" fragment="single">MPQTDPTARFEPFALTEVQESFYVGRTLGGGNGPGTQIHLEFEADAFDTDRAEAAWNDVVAATDMLRAHVLPDARQTVREEVTAHRFVRADLTTAAPAERDAELARLRREALAGFDPHRWPLFAIRVAHLAGGRARVLFTVDELIADGPSVSLLLQQWYERYAHGSVVTEPGLTFREYCTAGAGAEVPAASLAYWRDQLADIDLERPLPLGGGAADGPGHRRLALRLEPDRWERVKAAAKEARATPTALLLALCTAAVQGADGGGQAPLPVVLTTYNRQRVHADVPRLVGPFISTSVFVAPPATGTAGERLDLVRARLWSDLEHAAVSGVRALRERARTEPGRRGLAVPMVFTSLLGSLSALTDDPDNWAARVDLESSATLTPGVHLESCVQERDGALLVSWDFAPTAVDGTLTENAFAALRTALERIAREGTDAFALPAALPGCDDGAGSTDEAGDPIPLTDVQSAYLVGRIGGLGGNAETRVYQEFLLRRHDVDALERAWNRLVAHHPMLRAAVHEDGTLTVAPTVTPYRIARHDLTAAADVEAALAGIAARLRDTTFPLGSSPMYTLEASALPDGTVVLHVLLDALLADARSFALLFGQLFALHDGDDRVLDTPADPTAHLRALPERRRTGAGERARTAWREKFAALPSGPALPEPAPGAPRAHRRAPLGSWRELTERAAAIGVPADLVLLTAYTDELRAEYGAAGPFTVTVVSWDRPHGLAHADAMVADFTQLAWVTVDDSLPDGFAERARELWSRVRGDLERAELVPGLGELRTRVFRSGGALRLPVVFTRVPEIDPALHPDGVLLRTSQSQTAQVALDHVPLLVGDELAGQWDAADGALAPDRLDAMFERYARRVREFVAGEQASEQGSEQGSEAGSEQGSEQGSEQASDLAGSAGSVDDHTPVTLVELVEAAFAGHAERDAVHYAGRTLTYGELDRRTARLARHLHALGVRPGDHVAVHMDRSERLVATLIGIVRAGAVYVPVDPANPPERVRYLLQDSGAKVVVADEALATVPTEAGAVVVCPDRDADRAALHALPSTAPAVTVGPDDPVYTIYTSGTTGRPKGCRNTQQGVANRLLWMQDRFRLTPDDRVAQKTPYGFDVSVWEFFWPLLAGASIVVARPGGHVDPGYLAGLLRDEKVTVTHFVPSVLGMFLRHPAASACTALRTVFTSGEALPVATMRQFYEVFEARGQAACGPELHNLYGPTEAAIDVTHWACRPDWDEPTVPIGRPVAHTRIHVVDERLRPVAPGTPGEILIGGRQVALGYHGRPELTAERFVASPFPGLDPSPRLYRTGDLGLVGEDGEIRYLGRIDGQFKLRGLRIEPEEIEAALADVPGVAEARVLPVQDEASGEQVLAAVCVARERDRAPLVSQIRRALGDLLPAYLIPSHFRFVEDLPLTTNGKLDRPAAAELFGVKPASAPVSGTDVRGDIRAAVADVLGVAELDGGADLFDLGATSFTMIRIAQEIERLTGTALPVDALISKPTLDALTAAAVPATDAAPATPPASPASPASSNGAAAPIGAEDVARSAAGILGVDRVDLDADLFDLGATSFTMIRIAQEIEAVTGTQVPVDVLIQSPTPRSIAQSVAPKPAPATPASAPTASATGPDVRIALDPAAKAAFKEARVAERVLPPSLRRVPVPPAAPDEARALFDASSFREFAAGPLPAHDLLGLLAGVTWGELDGRAKRRYPSGGGFYPVQVYVYVAPGAVQDLAPGLYYLHPAERALIAVAPDARYGTDLHVHHNRALVAGSGFGVFLVSTPAAIAPAYGERNATRFSTVEAGHIAQLLLTGAPERGLGLCAVGEMDFDAVRGDFGVGGDQELLLSLWGGALTEQTRGRRAALAPAALAPAALAPATPVLTPQGERAVAVVGFAAELPGARTLDELDDLIARSGTATGPAPVQRWAPLRSRARRAGAAVGGYLDDVLAVEAEEFRIPEAEGSAIDPQERILLSVARRCFEDAALTPDRLDGRVGVYVGSMWQDHALYGVAARADERAEDGTHATRGGLAHRTSHAFGLTGPSLLIDSGCVSGLAAVEAAYRAVADGRCEAALAAGSNLVLHPDHLDVLSEMGLVAQDADSCAFTDRASGWLVGEGVGAVLLKPLDRALADGDPVHAVLRGGALQHSGTTRQFGIPDPERQEATMRAALDDAGVGPADIGYVEAAAAGAALADALEFTALGRLFGGDGSGTAPVPVGTVKPHTGHLEAASVFAQLGKVVTQFRRADVYPTLLTSAVNPALNRTGGSVALAAEGADSWRTAPGAPRRVLVNGFAGGGSYGSLVVEEPPAVEPGPDDQGTWALPLSADTPQNLAALADSLADAWARDPSLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JHM6</accession>
    <name>A0A2M9JHM6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Multidrug ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CG723_39680</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000031">
        <property type="protein sequence ID" value="PJN06381.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN06381">
        <property type="protein sequence ID" value="PJN06381"/>
        <property type="gene ID" value="CG723_39680"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221">
        <property type="entry name" value="PTHR24221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="SSF90123"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="43"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="83"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="161"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="186"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="264"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="9">
        <location>
            <begin position="44"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="8">
        <location>
            <begin position="359"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="392"/>
            <end position="399"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PJN06381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="596" mass="63501" checksum="9036ED216BA480C0" modified="2018-04-25" version="1">MIGLAPPAYDPAAPTTANTLPVGAPATVRSYVRELYQRHRRAFLLLIGVNTIAVVASMVGPYLLGALVQDVSDGTDRLRVEHLGSTITVFVVALVVQAVFVRQVRLRGAMLGERMLADLREDFLVRAVGLPPGVLERAGTGDLLSRITTDIDRLANAMREAVPQLSIGVVWVGLLLGGLAVTAPPLAPAVLVAVPLLVVGCRWYFKRAPSAYRSEAAGYAAVAAALAETVDAGRTIEAHRLGARRVGMSDQRVKEWTAWERYTLYLRSVFFPVINATHVTVLCAVLLIGGVFVLQGWIGVGQLTTGALIAQMLVDPLGLILRWYDELQVAQVSLARLVGVRDIEPDAGDASVAPDGRHVQADDVHFGYRAGVDVLREVSLDVRPGTRLALVGPSGAGKSTLGRLLAGIYAPRAGQVTLGGAELSRMPAERVRSHVALVNQEHHVFVGSLRDNLRLARTGAEDAELWAALGAVDADGWARALDGGLDTEVGSGAVALTPAQAQQIALARLVLADPHTLVLDEATSLLDPRAARNLERSLGRVLDGRTVVAIAHRLHTAHDADVIAVVEEGRIRELGSHDQLVAADGAYAALWRSWHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JIE2</accession>
    <name>A0A2M9JIE2_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Transport permease protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CG723_37850</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CB01635</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the ABC-2 integral membrane protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000027">
        <property type="protein sequence ID" value="PJN06651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN06651">
        <property type="protein sequence ID" value="PJN06651"/>
        <property type="gene ID" value="CG723_37850"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046677">
        <property type="term" value="P:response to antibiotic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC_2_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000412">
        <property type="entry name" value="ABC_2_transport"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01061">
        <property type="entry name" value="ABC2_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006648">
        <property type="entry name" value="DrrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51012">
        <property type="entry name" value="ABC_TM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0046">Antibiotic resistance</keyword>
    <keyword evidence="8" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="25"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="58"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="101"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="140"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="169"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="234"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="domain" description="ABC2_membrane" evidence="9">
        <location>
            <begin position="11"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PJN06651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="261" mass="27298" checksum="2EFFA2A2883B48B3" modified="2018-04-25" version="1">MTTALLYDGTAMLGRHLQRIRHAPAILVMTQTMPIVFLLFFGYVFGSALAMPGADYRAFLVPGMLVATAANGIMTGMFTAAQDSHRGVMDRFRTLPMTRAAVPLGQAAADIVTTAAGLVPLLAVGLAMGWRIEGGALEAVGAFGLLLLFRFATTWVGILLGLASRSEEAAGQLGGATFMLPLLSNAYIPTAGFPGWVRVLAEWNPISAVATAVRDLFGNAPVPGGSSWPVAHPVAGSLAWCAVLLAVCVPLAVRRYTTGGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JIM9</accession>
    <name>A0A2M9JIM9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">TetR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_37300</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000026">
        <property type="protein sequence ID" value="PJN06741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN06741">
        <property type="protein sequence ID" value="PJN06741"/>
        <property type="gene ID" value="CG723_37300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="12"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="35"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN06741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="215" mass="22889" checksum="B18453C1E67A36F4" modified="2018-04-25" version="1">MGEVRVKRMPRAVRERQMLDAAVRVFGERGYRAASMDEIAEFAGVSKPLVYLYLNSKEELFSACIQRESAALVAAVRVGVSGGGDADRQLWDGLRAFFTHTAQNPDGWAVLHSHARTGGEPFVVEVTAVREEIVAFVTGLLAAAARKAHGDPALPDREVAGLAQALVGAAESLAGWANTDPSVTAKEAAATLMNFAWSGLGNLMEGRRWSPAPGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JJ52</accession>
    <name>A0A2M9JJ52_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">UPF0434 protein CG723_37145</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_37145</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0434 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000025">
        <property type="protein sequence ID" value="PJN06905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN06905">
        <property type="protein sequence ID" value="PJN06905"/>
        <property type="gene ID" value="CG723_37145"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01187">
        <property type="entry name" value="UPF0434"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005651">
        <property type="entry name" value="Trm112-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03966">
        <property type="entry name" value="Trm112p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN06905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="56" mass="5873" checksum="BB0908812DD86E69" modified="2018-04-25" version="1">MPLEAGLLEILACPACHAPLKEADAELLCTGSDCGLAYPIRDGIPVLLVDEARRPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JJ82</accession>
    <name>A0A2M9JJ82_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ATP-dependent acyl-CoA ligase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_36145</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000024">
        <property type="protein sequence ID" value="PJN06936.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN06936">
        <property type="protein sequence ID" value="PJN06936"/>
        <property type="gene ID" value="CG723_36145"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-binding" evidence="1">
        <location>
            <begin position="32"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding_C" evidence="2">
        <location>
            <begin position="444"/>
            <end position="519"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN06936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="547" mass="59441" checksum="63622406979F219B" modified="2018-04-25" version="1">MTATTAPGNGARGLEDFPDLADGTVGGLLTVRAAEHPDKLALVCEDTELTYGALDTAATDVARGLLSTGAAPGSSVGIFLPNRTEYLLAWLGAARAGLVEVPINTAYKGSFLDHALRSTDVRVLVTEAALLELVADLPDVPQTLKTVVLLDNDRPRRIPPGVTVQTWSDLLAAGDPAAELPRVASHNPVAIMLTSGTTGRSKGVVHPHLMQLVAARECAMQMATTADERLYTCLPLFHGAAQINISMHALYAGSTVVLGRRFSASRFWDELRTHRVTQFNALGSILPMLLAQRPSDRDRHHQATKAFAAPAPPQVLHPFEERFGVHIIEGYGLTEIKNVLYNPLSARKVGSLGRPTESTILEIHDESGNRAAPGQAGEIVYRPRLANIMFSGYHHDPEATLATVKDLWWHTGDLGYTDEDGYFYFIDRKKDALRRRGENISSHEVESVLLAYPGVVAAAAIGTPSELGEDEVLAVVQLDLGHELDYAELFAHCDRSMPHFMVPRYFRVVDQLPATANGKVRKHQLRDQGRADAWDALAAGLNPTRHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JJ93</accession>
    <name>A0A2M9JJ93_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">TIGR03084 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_36180</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000024">
        <property type="protein sequence ID" value="PJN06941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN06941">
        <property type="protein sequence ID" value="PJN06941"/>
        <property type="gene ID" value="CG723_36180"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017517">
        <property type="entry name" value="CHP03083_actinobac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017518">
        <property type="entry name" value="CHP03084"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034660">
        <property type="entry name" value="DinB/YfiT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024344">
        <property type="entry name" value="MDMPI_metal-binding"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11716">
        <property type="entry name" value="MDMPI_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109854">
        <property type="entry name" value="SSF109854"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03083">
        <property type="entry name" value="TIGR03083"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03084">
        <property type="entry name" value="TIGR03084"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MDMPI_N" evidence="1">
        <location>
            <begin position="27"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF11716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN06941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="268" mass="29017" checksum="1B45F604B11A151B" modified="2018-04-25" version="1">MGCGVPCELIDDLAAEFNSLQTLITSGTDLRQPTPAAGWDIGASVSHLIGCDLLAEKAIATPGAFQCALPAADDGLTELLAGHIAARQDLRVEQLRQEWTDAFTALLRAFQSAHQHQKVPWFGPPMSPATLATARLMEYWAHGQDVAEALKVVRQHTDRIRHVCHLGFATFEFSFANRGLPVPPSPPRVELRLPSGRPWVRGPEDAHAVVTGDALDFALAVTQRRHWLDTSLTYQGEVAEQWLAIAQCFAGPPGPGRAPSEVPSARGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JJ97</accession>
    <name>A0A2M9JJ97_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_36295</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000024">
        <property type="protein sequence ID" value="PJN06956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN06956">
        <property type="protein sequence ID" value="PJN06956"/>
        <property type="gene ID" value="CG723_36295"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="49"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="77"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="129"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN06956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="148" mass="16262" checksum="1F01C46DBFAD1811" modified="2018-04-25" version="1">MLNALEIVTTVVVGVMVGVEFSVAFVMNRIFNALPEDSGQLGRAHGGRMLGAVMPFWYIGSLVLVAVWAVAGWHHHGTGLVVTAGALLILSVVMSILLLVPINNRGKTWTPDNRPEDWKEQMNRWDRFHYVRVAVIIAAFALLVTALT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JJJ9</accession>
    <name>A0A2M9JJJ9_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">30S ribosomal protein S18</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4 7" type="primary">rpsR</name>
        <name evidence="7" type="ORF">CG723_35550</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CB01635</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Part of the 30S ribosomal subunit. Forms a tight heterodimer with protein S6.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4 5">Belongs to the bacterial ribosomal protein bS18 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000023">
        <property type="protein sequence ID" value="PJN07049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN07049">
        <property type="protein sequence ID" value="PJN07049"/>
        <property type="gene ID" value="CG723_35550"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00270">
        <property type="entry name" value="Ribosomal_S18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001648">
        <property type="entry name" value="Ribosomal_S18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018275">
        <property type="entry name" value="Ribosomal_S18_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036870">
        <property type="entry name" value="Ribosomal_S18_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13479">
        <property type="entry name" value="PTHR13479"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01084">
        <property type="entry name" value="Ribosomal_S18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00974">
        <property type="entry name" value="RIBOSOMALS18"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46911">
        <property type="entry name" value="SSF46911"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00165">
        <property type="entry name" value="S18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00057">
        <property type="entry name" value="RIBOSOMAL_S18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="4" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0699">rRNA-binding</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="10"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PJN07049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="86" mass="9963" checksum="6DD2BA823F1E4DCD" modified="2018-04-25" version="1">MPPRNPARNPVGRPDRKPAKSRPNPLDHAKITYIDYKDTDLLRKFISDRGKIRSRRVTRVTAQQQRQIAAAIKNAREMALLPYVTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JJT5</accession>
    <name>A0A2M9JJT5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="10">ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CG723_35500</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CB01635</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000023">
        <property type="protein sequence ID" value="PJN07138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN07138">
        <property type="protein sequence ID" value="PJN07138"/>
        <property type="gene ID" value="CG723_35500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003838">
        <property type="entry name" value="ABC3_permease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025857">
        <property type="entry name" value="MacB_PCD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02687">
        <property type="entry name" value="FtsX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12704">
        <property type="entry name" value="MacB_PCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015006584" evidence="7">
        <location>
            <begin position="43"/>
            <end position="753"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="165"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="206"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="268"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="317"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="347"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="614"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="658"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="688"/>
            <end position="707"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="719"/>
            <end position="745"/>
        </location>
    </feature>
    <feature type="domain" description="FtsX" evidence="8">
        <location>
            <begin position="186"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="domain" description="MacB_PCD" evidence="9">
        <location>
            <begin position="436"/>
            <end position="582"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF12704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PJN07138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="753" mass="77192" checksum="EE5D5151B84021D0" modified="2018-04-25" version="1">MTTLTSAWANLRTRRHLFAGAFVAVALGVALVASMGLGLAAAADPPPGKPQRFAAQPVVVMPHDTLTVEVDRGPNRARDTKKTPYPQPVDKELLGELADLGTVHRDHLAPDAVGVDASATAVREVVGDRAQVLTGAARHLADPGAERDAQAVVAVRAMLGTAGGVSAFVAVFVTASTFAFVVALRRREFGLLRLAGATPGRVRRQLVTEALAVGVAASATGCALGSWGAPLLARALIDNGIAPTWFTVSGSGTALWTSWASWSYWASWPFQLAFWTGLFVAIAGAWAASRRAGRIGPVEALRDADVDTDVMPWSRRIVGAALLSLGLGLTVHTLWTDPSALLKRKTYTTQPMILITAAAALAPLLVHPVLRLVRLPGAVGLLVRENAAASVRRTAAVAAPVLITVALAGSLMGSAESVSAAKAQEASEQMHAQLIATGDDLRLARRPVPGVAAVSPSASAAVFVREEGTALLRSEARGVSDPAALAATSRLPVVAGDIRRLDDRSIVVNEEWEHHRVGDRLTVWLGDGRRTTLRIAAVLARGTGDNGAYVTMANAGAAPVDRIDVRLTPGASPATAAGALRAATSGHDVRVRTAAAWLDATHPRVKPQTRQGMLLLLGIALTYTTISLAGTQLMAASVRDGELRALRRAGATRGQVRWMLAGEALVAVAAGTALGLAVTALNLGGLAAALDLLAPGSGAGAGLGTGLGSGTGNGPGVVVPWGVVGSAVGVCAVVAVGAGVLGAGWGRRNGVRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JK50</accession>
    <name>A0A2M9JK50_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Polyketide cyclase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CG723_35275</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000022">
        <property type="protein sequence ID" value="PJN07251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN07251">
        <property type="protein sequence ID" value="PJN07251"/>
        <property type="gene ID" value="CG723_35275"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019587">
        <property type="entry name" value="Polyketide_cyclase/dehydratase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10604">
        <property type="entry name" value="Polyketide_cyc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PJN07251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="142" mass="14884" checksum="0E0D1BDB58662E18" modified="2018-04-25" version="1">MAEVSAEARIGAPAEKVWAQLTDFTAYGEWNATHTSFPKGAPTALEVGGTFEENMKLMGFPAEVTWTVEDLQTTRTLAIKGKGPMGVTVGTRYTLTADGDGTTVRIDGEFTGAAVSLMAGKLKDSATAALNESLRKLAGLVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JKN8</accession>
    <name>A0A2M9JKN8_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">LPG_synthase_C domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CG723_33495</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CB01635</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000020">
        <property type="protein sequence ID" value="PJN07422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN07422">
        <property type="protein sequence ID" value="PJN07422"/>
        <property type="gene ID" value="CG723_33495"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024320">
        <property type="entry name" value="LPG_synthase_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09924">
        <property type="entry name" value="LPG_synthase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="59"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="101"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="150"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="181"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="242"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="domain" description="LPG_synthase_C" evidence="8">
        <location>
            <begin position="278"/>
            <end position="582"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF09924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PJN07422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="634" mass="69464" checksum="ECBD5FBD1890D9FF" modified="2018-04-25" version="1">MVSSTFSRHLRCSAVFTGKEARRPKKVCRPPRSYRAVVSLLLQRCGALLRSVTVKQRPAAVAGHTCLIIGILDIASAISPHMHETRIERIAPYVPGLAEEVARAAALAAGLLLVMLARGLRRRKRRAWEAAVGLLAVSALVQGVRHHALIPAMVSAVLCVALVAYREEFYALGDPRGRTRALWNLVVLGGSSFGLGLLVVGVRANQEAGHSIVFTERVQEVAYGLFGASGPIAYSSDKAADIVQFSLLALGVVTAVTSVYLALRPVTLRPADSDERLRALLADEGRRDSLGYFALRGDKSVLFSPSGKAAVAYRVVSGVALAGGDPIGDYEAWPGAIKEFLRQCALHAWTPAVMGCSELGGQVWVREGGLKALELGDEAIVDCAAFSLSGRSMRNVRQMVNRIERAGYTCRMQRVRDLPDEEKKRLREAAAAWRGSATERGFSMALGRFGDPDDGDCVVVTAHQDDEAGNDRVRALLHFVPWGQDGLSLDLMRRDRTAEPGLNELLIVAALRGAPGLGVRRMSLNFAVFRAALARGERLGAGPVLRVWRGMLVFLSRWFQIESLYRFNAKFRPEWEPRFVVYPTVRDLPRISWACLQAEAFVVLPRPAERLRQLLRSRPAAREEKPQPMEVTTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JL66</accession>
    <name>A0A2M9JL66_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">AsnC family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CG723_33615</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000020">
        <property type="protein sequence ID" value="PJN07517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN07517">
        <property type="protein sequence ID" value="PJN07517"/>
        <property type="gene ID" value="CG723_33615"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000485">
        <property type="entry name" value="AsnC-type_HTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019888">
        <property type="entry name" value="Tscrpt_reg_AsnC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019887">
        <property type="entry name" value="Tscrpt_reg_AsnC/Lrp_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01037">
        <property type="entry name" value="AsnC_trans_reg"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13404">
        <property type="entry name" value="HTH_AsnC-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00033">
        <property type="entry name" value="HTHASNC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00344">
        <property type="entry name" value="HTH_ASNC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH asnC-type" evidence="6">
        <location>
            <begin position="25"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="domain" description="AsnC_trans_reg" evidence="5">
        <location>
            <begin position="90"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="domain" description="HTH asnC-type" evidence="6">
        <location>
            <begin position="200"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="domain" description="AsnC_trans_reg" evidence="5">
        <location>
            <begin position="270"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="179"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PJN07517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="359" mass="39065" checksum="8982BE3E91F3B4E5" modified="2018-04-25" version="1">MQDRDGSRTLGGLGAPGEQAELDELDELDRGVVHALQVHPRASWALVGEVLGVDPVTAARRWRRLEKAGLAWVTAYPRLTDARIVVTGVIEVDTEPGAAEDVAQALADDPAVPNVKLTAGGRDVVASVQTRTLDELSRLSGSLFRPVPGVRATRTHVSTGLPTEGSRWRLRSLDAVQTGRLEQKARPPAPTGSPVPPRWDSLDARLLELLSVDGRMSLRDLSAASDAPLTTVRRRVESLLASRLLLRCDLARPLSGWPLSAVYFASVPGQYLEETSRVLSQVPEVRSCAITAGPHNLVVDVWLRTLHDVHTFEAHLSRKLPRLTVADRSVVLRTVKHMGRLLDRGGRSVGVVPLQHPED</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-06-02" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JLA3</accession>
    <name>A0A2M9JLA3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_33290</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000019">
        <property type="protein sequence ID" value="PJN07638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN07638">
        <property type="protein sequence ID" value="PJN07638"/>
        <property type="gene ID" value="CG723_33290"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035214">
        <property type="entry name" value="DUF5324"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17258">
        <property type="entry name" value="DUF5324"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="157"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="192"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="219"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN07638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="234" mass="25261" checksum="7CCAB002A806CB61" modified="2018-04-25" version="1">MTRIDSVRAATSSAKDSVLHAAEVVAPYAETAKDRTALYAQEARVRLAPVMSQAAQQTRDQYDTYLAPHLEQARSHVPPKIDQAAQDAAVRTRKAARQAADYARPRIEQAVAATQPVREEATARSVAAIAALRGQVSPKEIQKLVRKHERRARAGRVAKGFLVVGILAGGAFAAWKWWDKQANPDWLVEPPAATEVADSTPLSSVDGNQGALDPEVQAKQAEAEADAADRNDRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JLE3</accession>
    <name>A0A2M9JLE3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">TIGR02611 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_32000</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000018">
        <property type="protein sequence ID" value="PJN07700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN07700">
        <property type="protein sequence ID" value="PJN07700"/>
        <property type="gene ID" value="CG723_32000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013434">
        <property type="entry name" value="CHP02611"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019099">
        <property type="entry name" value="Uncharacterised_PGPGW_TM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09656">
        <property type="entry name" value="PGPGW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02611">
        <property type="entry name" value="TIGR02611"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="44"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="71"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="117"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN07700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="148" mass="16173" checksum="BB03B6791B3F4195" modified="2018-04-25" version="1">MNTGSDEAAESESVSATTGDGAKAEPELGSRAPEFIKARRALHLSWQVGVFVVGLAVVVAGVIMLPLPGPGWLVIFGGMAIWATEFVWAQLVLRWTKRKVTEATQRALDPAVRRRNIILTSIGVVIIAVLVGIYVWKFGFEMPWKIKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JLX1</accession>
    <name>A0A2M9JLX1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Type III effector protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CG723_31290</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000017">
        <property type="protein sequence ID" value="PJN07880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN07880">
        <property type="protein sequence ID" value="PJN07880"/>
        <property type="gene ID" value="CG723_31290"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PJN07880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="214" mass="22944" checksum="AD547F3DBE2C9BE0" modified="2018-04-25" version="1">MFVDGYRQAPASFLAAAAALETINEAVHSAQNAQEPSAHGEQVSSDEALAALLMLRELREQLAGWEPGLIEAARAAGTSWADLAHPLGVASRQAAERRYLRVRPGAPGTTREQRVQATRSRRAADRTLTAWARTNAADLRQLAGQIIALTDLPAQAQPPLARLTEALADNDAANLITPLSATHVHLKAGHPELAARIDTLTRNTGHLRQGNDVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JM20</accession>
    <name>A0A2M9JM20_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Acyl-CoA dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CG723_31630</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000017">
        <property type="protein sequence ID" value="PJN07926.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN07926">
        <property type="protein sequence ID" value="PJN07926"/>
        <property type="gene ID" value="CG723_31630"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016627">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013107">
        <property type="entry name" value="Acyl-CoA_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08028">
        <property type="entry name" value="Acyl-CoA_dh_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="SSF47203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="SSF56645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA_dh_N" evidence="3">
        <location>
            <begin position="21"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_M" evidence="2">
        <location>
            <begin position="127"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_2" evidence="4">
        <location>
            <begin position="234"/>
            <end position="373"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PJN07926.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="398" mass="42273" checksum="240CFA2CA23C915C" modified="2018-04-25" version="1">MPSSVTPHISVSAPADLLHRIRAVAASLEAARELPYKSVQLVRDSGLGALRVPREYGGAGGSLVDLFRLVIDLAEADSNVAQALRPHFGFVELLISQGTAAERARWYPTVVAGELFGNAASERGTAHPGEIRTRLTRDGDAYRVDGTKFYSTGALFADHVVVIALDDAERRVRVVLPRSREGVELVDDWDALGQRTTASGTTRLRQVAAYGDEVTVDATGWQRRTHMGPYYQLFLAAVHAGIAKAALADALSYAREKARAVQHAGVERAVDDPLVQHTVGEIAAGALAAEAVVLHAASVIDAALAVPADDGITGDQDALHSAAATVAQAQVTAARAALSAGERLYDVGGASATLREHHLDRHWRNARTVASHNPVAHKARVCGDWLLNGTPPPLNGFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JM39</accession>
    <name>A0A2M9JM39_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">SfnB family sulfur acquisition oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CG723_31600</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000017">
        <property type="protein sequence ID" value="PJN07922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN07922">
        <property type="protein sequence ID" value="PJN07922"/>
        <property type="gene ID" value="CG723_31600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016627">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013107">
        <property type="entry name" value="Acyl-CoA_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023922">
        <property type="entry name" value="S04_starv_induced_SfnB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08028">
        <property type="entry name" value="Acyl-CoA_dh_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="SSF47203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="SSF56645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04022">
        <property type="entry name" value="sulfur_SfnB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA_dh_N" evidence="3">
        <location>
            <begin position="25"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_M" evidence="2">
        <location>
            <begin position="140"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_2" evidence="4">
        <location>
            <begin position="247"/>
            <end position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PJN07922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="404" mass="44209" checksum="E4D5331454D33425" modified="2018-04-25" version="1">MNRATHTTRVTPFGPDSTEAEVLVVVRQLAARFSTEDARRDAERILPYEEIRTLSGAGLFTLSVPKAYGGPGLSTRTLGEVFTELVAGDASIGQIPQNHFFFVNVLASAGTPEQQAFFYEEILRGRHFANALSERGSRTARDFEIGFARQPDGSRILNGTKYYATGTLFAHWIPVYAADEEGRVHAAWVPADEPGVTVEDDWNGMGQRTTGSGTVRFEQVRVPAERIVPVYTIFEKDEVFGAFGQYLHAAIDTGIAVAALRDGKRLIHELARPRKETGLDRAADEEAIIDLFGELALGVRTARALLREAGDAVDAARADLNTLTAAEASAAVAAARAHSDEVSLKVSSGIFELIGTRAADRDLNLHRHWRNARTHTLHDPRRLKLRYLGGWELNDTPPPANGLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JML7</accession>
    <name>A0A2M9JML7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glyoxalase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_30470</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000016">
        <property type="protein sequence ID" value="PJN08102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08102">
        <property type="protein sequence ID" value="PJN08102"/>
        <property type="gene ID" value="CG723_30470"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041581">
        <property type="entry name" value="Glyoxalase_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18029">
        <property type="entry name" value="Glyoxalase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VOC" evidence="1">
        <location>
            <begin position="6"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN08102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="117" mass="13095" checksum="3432D6395CFD369F" modified="2018-04-25" version="1">MERVLGIGGYFMRADDPAALSAWYRDCLGLDADEHGLWRQGAGLTVFATFESETDYFGSRAQQTMLNFRVRDLDAMLAQLRAKGADVAEETQDMEGVGRFGWVTDPEGNRVELWQPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JMR3</accession>
    <name>A0A2M9JMR3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">AraC family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_30130</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000016">
        <property type="protein sequence ID" value="PJN08097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08097">
        <property type="protein sequence ID" value="PJN08097"/>
        <property type="gene ID" value="CG723_30130"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002818">
        <property type="entry name" value="DJ-1/PfpI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01965">
        <property type="entry name" value="DJ-1_PfpI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="1">
        <location>
            <begin position="210"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN08097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="325" mass="34079" checksum="8AA40B1DE2DA53C1" modified="2018-04-25" version="1">MVIVAFDQVQLLDVTGPTEVFTTATATTGGAAYDVRIVSPDGADVRTSSGVRIGVDIGPDALPRRIDTVLVPGRSDWRAAVHDTELVAFTAQLARRARRVASVCAGAFLLAEAGLLDGRRAATHWRLAADLATAYPAVTVAHDPIYVRDGPVVTSAGVSAGIDLALALVEEDHGADTARDVARELVVFMARPGGQSQFSARLTPATGQHPAVRAAMDAAGADPRVASDLTVLAEVAGVSPRHLTRLFRADTGMTPGQYIESVRLEAARALLEGGGDPVEHIAQAAGFGSSESMRRAFQQTLGVAPTEYRARFRTTHTTNPTVTPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JMY7</accession>
    <name>A0A2M9JMY7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CG723_29935</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CB01635</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000015">
        <property type="protein sequence ID" value="PJN08224.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08224">
        <property type="protein sequence ID" value="PJN08224"/>
        <property type="gene ID" value="CG723_29935"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045621">
        <property type="entry name" value="BPD_transp_1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19300">
        <property type="entry name" value="BPD_transp_1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="9"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="116"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="149"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="192"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="294"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="110"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PJN08224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="329" mass="35560" checksum="AD00E6BEE5F8C27C" modified="2018-04-25" version="1">MTGFLLRRVIGAAVTLLAISVIIYVVFYAAPGNVAQISCGPRCSPAQVQQVADQLRLDDPLYLRYWHFLQGIFVGQDFSTGTAVQHCDAPCLGFSYQTDQQVTQLILTKLPATASLALGAMVLWLILGVGTGVLSAWRRGRPTERILTGITLAGTATPVFVIGLLLMIVVCGQLQWLPFPQYVPFTDNPEQWAWNLLLPWLSLALIEAAKYARLTRASMLETLAEDHVRTFRAYGVGERSIIGRHALRGAVAPVIALNANDFGSMFGGAVLSETLFGIPGLGRELVHAVNVVDLPVVVGMVLVTGFFVVLANAVADVLYAVADRRVVLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JN56</accession>
    <name>A0A2M9JN56_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Arsenical-resistance protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">arsB</name>
        <name evidence="6" type="ORF">CG723_28290</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CB01635</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 3">Belongs to the arsenical resistance-3 (ACR3) (TC 2.A.59) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000014">
        <property type="protein sequence ID" value="PJN08301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08301">
        <property type="protein sequence ID" value="PJN08301"/>
        <property type="gene ID" value="CG723_28290"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015297">
        <property type="term" value="F:antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015103">
        <property type="term" value="F:inorganic anion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004706">
        <property type="entry name" value="Arsenical-R_Acr3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002657">
        <property type="entry name" value="BilAc:Na_symport/Acr3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038770">
        <property type="entry name" value="Na+/solute_symporter_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43057">
        <property type="entry name" value="PTHR43057"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01758">
        <property type="entry name" value="SBF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005508">
        <property type="entry name" value="Acr3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00832">
        <property type="entry name" value="acr3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="3 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="23"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="48"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="90"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="119"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="151"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="194"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="233"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="263"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="297"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="325"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="359"/>
            <end position="380"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR005508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PJN08301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="380" mass="40354" checksum="EC39A5E6E564657A" modified="2018-04-25" version="1">MTETATAPPSGPVSARLSFLDRFLAVWILAAMAVGLGLGRLVPGLGDALAEVIVAGVSLPIALGLLVMMYPVLAKVRYDRLDTVTRDRRLVIPSLVLNWVLGPALMFALAWILLPDLPAYRTGLIIVGLARCIAMVVIWNDLACGDREAAAVLVALNSLFQVLAFSLLGWFYLSVLPGWLGLEQTALDVSVWEIARSVLIFLGVPLLAGYLTRRLGERAKGRTWYEAKLIPRIGPFALYGLLFTVVVLFALQGDAITSQPLDVVRIALPLLVYFAVMWAGSMALGKALGLDHPRATTLAFTAAGNNFELAIAVAIATFGATSGQALAGVVGPLIEVPVLVGLVHVALAARRYFPRPGPVVAEPDTPAAEPAPIEEGPARA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-06-02" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JNA4</accession>
    <name>A0A2M9JNA4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_28570</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000014">
        <property type="protein sequence ID" value="PJN08344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08344">
        <property type="protein sequence ID" value="PJN08344"/>
        <property type="gene ID" value="CG723_28570"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="159"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="159"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN08344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="216" mass="23261" checksum="EF698F63B12A97A9" modified="2018-04-25" version="1">MACDLWLVPLVDVLCHSPDNPFAEELALYDKALHEAGLPPVPVYSYMPGLSGDVAPVAGFDYDALHFLRRAYLLQMCGLAVTPVDELGGDYEQLLEMFETTAQQSHLVWHYDHAGAYVPVDFPSPLSNDELLAGGGPLGSSHALLRELEYVARSIGIDPANPPAPPVPPEGPTSLEEPAAPAPLDDSPFARERHVWLGLHAAATRSLAQGSMIIFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JNI9</accession>
    <name>A0A2M9JNI9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Dioxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CG723_29080</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CB01635</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the intradiol ring-cleavage dioxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000014">
        <property type="protein sequence ID" value="PJN08429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08429">
        <property type="protein sequence ID" value="PJN08429"/>
        <property type="gene ID" value="CG723_29080"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008199">
        <property type="term" value="F:ferric iron binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016702">
        <property type="term" value="F:oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006725">
        <property type="term" value="P:cellular aromatic compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000627">
        <property type="entry name" value="Intradiol_dOase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015889">
        <property type="entry name" value="Intradiol_dOase_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00775">
        <property type="entry name" value="Dioxygenase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49482">
        <property type="entry name" value="SSF49482"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014676892" evidence="5">
        <location>
            <begin position="42"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="domain" description="INTRADIOL_DIOXYGENAS" evidence="6">
        <location>
            <begin position="65"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="125"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PJN08429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="312" mass="32714" checksum="9CE89B0504EC1119" modified="2018-04-25" version="1">MTETQGPAHKRDMTRRKVILAGGAAVAAVGVGGSIAANAFAGETDTADRKSEAESCYRLTSETTEGPYYIDADKLRRDITEDKEGIPMVLRLKVIDAETCKPLRNAAVDIWHCDALGIYSGYESLSTGGGGTPPSGAPSGAPTDQPSGTPTGAPPGGGGGGGHEEPTDDERYLRGTWKTDKHGSVEFRTIFPGWYRGRAVHIHTKVHVDGKWTDAGYEGGHTCHTGQFFFEEAAVIASGKVAPYSTSTTERTTLTEDTIYDQSGTTGGLLKLTYGKGRIAKGVIGSITMAVAPDETHDSTDTQPGASASTAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JNX3</accession>
    <name>A0A2M9JNX3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_27750</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000013">
        <property type="protein sequence ID" value="PJN08568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08568">
        <property type="protein sequence ID" value="PJN08568"/>
        <property type="gene ID" value="CG723_27750"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN08568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="185" mass="19458" checksum="7018245F43D9FE96" modified="2018-04-25" version="1">MVVQTVPPAEPEEGDLDEEGASEEVQVPTETPPKAPEVPPAAPCEAGYSWESTAKHGTYHKGVGAAQATTNNTSHSGKSTFTSETSGTVTVGISGTLKAKASAAVAEIESEYSVNLSVSLTAKIGNSYATTTPAHTVTHAKYGVYRLKTSGYSQYHYANCTKGVKTNATLYSPSHVGRYIWETKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-09-29" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JNZ8</accession>
    <name>A0A2M9JNZ8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">FAD-binding oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_27995</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000013">
        <property type="protein sequence ID" value="PJN08603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08603">
        <property type="protein sequence ID" value="PJN08603"/>
        <property type="gene ID" value="CG723_27995"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.45.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016164">
        <property type="entry name" value="FAD-linked_Oxase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004113">
        <property type="entry name" value="FAD-linked_oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016171">
        <property type="entry name" value="Vanillyl_alc_oxidase_C-sub2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02913">
        <property type="entry name" value="FAD-oxidase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55103">
        <property type="entry name" value="SSF55103"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="SSF56176"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="1">
        <location>
            <begin position="47"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN08603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="465" mass="49453" checksum="06247AE82D5BF9C7" modified="2018-04-25" version="1">MTDLSAALTALSHELGPDAVHTDEVSLDASSHDSWPLSTKLDKLGRHTHRADAVVTVDSEAAIRTVLAAAADHDVPVTVRALASSVTGQPLPVRGGIVLDVSALPATYNVNTEDLTVEASAGYNGGRLEAELQEQGWTLGHSPQSLHRSSVGGWLATLATGQFSSYYGGIEDLVVGYTVILATGETLRLSAAPRAAMGPDLRQLFLGSEGTLGVITSVTLKIFPVPPVRLLETYRLPSVEAGVAVMRAQAAAGLRPFVLRLYDTAEARHALQDDTVDRPVMFAGTQGLEAVARAEFDALSSIVGEHGGTATGPDGTEKWMARRFDFSGVENLLTEDGGYAETVEVAHNWSGILPLYHALTQALAPLADEVLAHFSHVYTQGTSLYLILRGKAETDEEAVRRLEQVWSTAMRVALEHGAELSHHHGGGLARSPYTKQSLGASHLLLRRLKNALDPNGLLNPGKLGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JP83</accession>
    <name>A0A2M9JP83_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_26645</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000012">
        <property type="protein sequence ID" value="PJN08678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08678">
        <property type="protein sequence ID" value="PJN08678"/>
        <property type="gene ID" value="CG723_26645"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002878">
        <property type="entry name" value="DUF35_OB-fold_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022002">
        <property type="entry name" value="DUF35_Znr_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12172">
        <property type="entry name" value="DUF35_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01796">
        <property type="entry name" value="OB_aCoA_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF35_N" evidence="2">
        <location>
            <begin position="21"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="domain" description="OB_aCoA_assoc" evidence="1">
        <location>
            <begin position="60"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN08678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="150" mass="16496" checksum="05809A809CB6E6FF" modified="2018-04-25" version="1">MTESEICYLSPVIDDDGAPFWRYAAQSQLRIQSCASPTCGELRFPPRPCCPHCGSFESEWRLMSGRGRIWSYVVPHPPLLPAYAAVAPYNAIIVELADAPRIRLVGNLVASADAALNSVDPARLRIGAKVQVAFTDVDGVTMPRWVLERP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JPD2</accession>
    <name>A0A2M9JPD2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_26880</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000012">
        <property type="protein sequence ID" value="PJN08716.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08716">
        <property type="protein sequence ID" value="PJN08716"/>
        <property type="gene ID" value="CG723_26880"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014644122" evidence="2">
        <location>
            <begin position="30"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="45"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN08716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="69" mass="6868" checksum="2193F4A5E5700588" modified="2018-04-25" version="1">MRMRRLLGLALATATLAGASAVGVATAQAATYPAISADQCTAQGGTVNQGGPYRGPTCSFPDGHSESIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JQ73</accession>
    <name>A0A2M9JQ73_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DNA-binding response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CG723_25620</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000011">
        <property type="protein sequence ID" value="PJN09018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN09018">
        <property type="protein sequence ID" value="PJN09018"/>
        <property type="gene ID" value="CG723_25620"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00622">
        <property type="entry name" value="HTH_LUXR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="3"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="domain" description="HTH luxR-type" evidence="3">
        <location>
            <begin position="148"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PJN09018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="214" mass="22524" checksum="3EDA88D52BBC002F" modified="2018-04-25" version="1">MIQVLVAEDQSAVRAGLVLILGSAPGIEVVGEAADGEQAVAMARALRPDLVLMDIQMPRLDGVSATRQVVSEGLADVLVLTTFDLDEYVFGALRAGAGGFLLKNTEAKDLIEGVRTVARGEGLIAPAVTRKLIAEFAAKPVRPEPGPAPAGLDTLTRREREVLSCLGDGLSNAEIAVRLEMAEATVKTHVSRLLGKLELRSRVQAAVLAQELGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JQM7</accession>
    <name>A0A2M9JQM7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CG723_25015</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000010">
        <property type="protein sequence ID" value="PJN09173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN09173">
        <property type="protein sequence ID" value="PJN09173"/>
        <property type="gene ID" value="CG723_25015"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PJN09173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="72" mass="7721" checksum="C35E0E12756B952C" modified="2018-04-25" version="1">MVVRDAERLRVVEETVAQLRAELGVLGVLLPSLRVDPVSAAGEVGYPLVDLGCVNLDTAMRLVAVLHDRRGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JQU6</accession>
    <name>A0A2M9JQU6_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">D-inositol-3-phosphate glycosyltransferase</fullName>
            <ecNumber evidence="7">2.4.1.250</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">N-acetylglucosamine-inositol-phosphate N-acetylglucosaminyltransferase</fullName>
            <shortName evidence="7">GlcNAc-Ins-P N-acetylglucosaminyltransferase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7 11" type="primary">mshA</name>
        <name evidence="11" type="ORF">CG723_24585</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CB01635</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2-acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>1D-myo-inositol 3-phosphate + UDP-N-acetyl-alpha-D-glucosamine = 1D-myo-inositol 2-acetamido-2-deoxy-alpha-D-glucopyranoside 3-phosphate + H(+) + UDP</text>
            <dbReference type="Rhea" id="RHEA:26188"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:58401"/>
            <dbReference type="ChEBI" id="CHEBI:58892"/>
            <dbReference type="EC" id="2.4.1.250"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the glycosyltransferase group 1 family. MshA subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.250" evidence="7"/>
    <dbReference type="EMBL" id="NNBL01000010">
        <property type="protein sequence ID" value="PJN09239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN09239">
        <property type="protein sequence ID" value="PJN09239"/>
        <property type="gene ID" value="CG723_24585"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008375">
        <property type="term" value="F:acetylglucosaminyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102710">
        <property type="term" value="F:D-inositol-3-phosphate glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010125">
        <property type="term" value="P:mycothiol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01695">
        <property type="entry name" value="MshA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028098">
        <property type="entry name" value="Glyco_trans_4-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017814">
        <property type="entry name" value="Mycothiol_biosynthesis_MshA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13439">
        <property type="entry name" value="Glyco_transf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03449">
        <property type="entry name" value="mycothiol_MshA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="6 7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_4-like_N" evidence="10">
        <location>
            <begin position="48"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="domain" description="Glycos_transf_1" evidence="9">
        <location>
            <begin position="240"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="UDP-GlcNAc binding" evidence="7">
        <location>
            <begin position="42"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="1D-inositol 3-phosphate binding" evidence="7">
        <location>
            <begin position="47"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="36"/>
        </location>
        <ligand>
            <name>1D-myo-inositol 3-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58401"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="50"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-glucosamine</name>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="105"/>
        </location>
        <ligand>
            <name>1D-myo-inositol 3-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58401"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="138"/>
        </location>
        <ligand>
            <name>1D-myo-inositol 3-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58401"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="162"/>
        </location>
        <ligand>
            <name>1D-myo-inositol 3-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58401"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="182"/>
        </location>
        <ligand>
            <name>1D-myo-inositol 3-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58401"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="257"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-glucosamine</name>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="262"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-glucosamine</name>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="323"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-glucosamine</name>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="332"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="333"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="335"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="345"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-glucosamine</name>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="353"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-glucosamine</name>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="359"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF13439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PJN09239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="449" mass="47947" checksum="6980DB1F6F9EC1F2" modified="2018-04-25" version="1">MSQYVSRLRRSGASSQRLRFPGAHRRPRRVAMLSVHTSPLHQPGTGDAGGMNVYIVELAKRLAAINIEVEIFTRATTGALPPAVELSPGVLVRHVDAGPYEGLAKEELPAQLCAFTHGVMQAWAGHRPGYYDLVHSHYWLSGHVGWLAAERWGVPLVHAMHTMAKVKNAALAEGDTPEPAARVIGETQVVRAADRLIANTAEEADELVRHYEADAGKVAVVHPGVNLERFCPADGRAAARHRLGLPQDALIPLFAGRIQPLKAPDILLRAVAVLLDERPELRSRIVVPVVGGPSGSGLAKPEGLHKLAAKLGIADVVRFRPPVGQDQLADWFRAASVLVMPSYNESFGLVAIEAQAAGTPVIAAAVGGLPVAVRDESTGFLVPGHDPTVYARRLGQFADRPQLVDSMGAAAAAHAQGFGWDTAASATADVYTAATYEHRHPRHVPSLHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JR15</accession>
    <name>A0A2M9JR15_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CG723_23535</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CB01635</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000009">
        <property type="protein sequence ID" value="PJN09321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN09321">
        <property type="protein sequence ID" value="PJN09321"/>
        <property type="gene ID" value="CG723_23535"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045621">
        <property type="entry name" value="BPD_transp_1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19300">
        <property type="entry name" value="BPD_transp_1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="9"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="101"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="134"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="177"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="239"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="281"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="95"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PJN09321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="314" mass="33436" checksum="3BC6F16600B7E740" modified="2018-04-25" version="1">MLTFITRRIAAGAVLLLVISFLSYVLLSIPDMDVGRQLLGEGASQNVIDAKNAQLGLDRPVLAQYTDWLSHAVRGDFGTSWFSSEDVSQAIANRLPVTVSLMLGVTVVTALVSFLLGAWAGVRRGGAVDRAVQILGVLGYALPGFLVTLILVLIFAVRLNWFPAIGYIPFTESPGGWLSTVTLPVISLSVASVAGVSQQVRGAVIDVLRQDYVRTLRARGLPPSRIVLKHVLRNASAPALSVLGMQFVGLLGGAVLVEQIFGLPGLGSMTVTYTTRGDIPVIMALVMLTVIGVVLINLLVDIMIGWLNPKARIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JR41</accession>
    <name>A0A2M9JR41_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Serine/threonine protein kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_23635</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ROK (NagC/XylR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000009">
        <property type="protein sequence ID" value="PJN09333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN09333">
        <property type="protein sequence ID" value="PJN09333"/>
        <property type="gene ID" value="CG723_23635"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000600">
        <property type="entry name" value="ROK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18964">
        <property type="entry name" value="PTHR18964"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00480">
        <property type="entry name" value="ROK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN09333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="410" mass="43214" checksum="A4A5FD6099B5FD68" modified="2018-04-25" version="1">MTAISDHARPPLLVALPARPEPLSVEGGGPGALLRTLLRDGPAARTELVARTRLSPAAVSRHTAELIGLGLLRELPPRVRPPRAGRPQVPVAIDPVHHVACGVHIALEHMTFAVVDLLGRVTAQRRLPHPGGPRQVLEEIGRLLPGFLGRHAAGRSVLGLGVVTGGWVDAEQGTVIEHAPLGWRDVPVRRVLGATTRLPVHVDGHARALAHAELLFGAGAGRSDLVQLFVGNVVDAAIAAGGSVLRGRRSGAGDVAHLPLGHIGQACGCGRTGCLQTAVSELAVAERAFETGTIPAPDFALLLDRARQGHHEALRVLRERLRTVGRAAALLLDVLNPELLVVVERTALTFPELLPDLHEEIAAHSHLCGDPERAVVPSSFGPHVLAVAAGSVVLDAVYRRPMELRTARSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JR94</accession>
    <name>A0A2M9JR94_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_23950</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000009">
        <property type="protein sequence ID" value="PJN09383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN09383">
        <property type="protein sequence ID" value="PJN09383"/>
        <property type="gene ID" value="CG723_23950"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006059">
        <property type="entry name" value="SBP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01547">
        <property type="entry name" value="SBP_bac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014864068" evidence="1">
        <location>
            <begin position="37"/>
            <end position="462"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN09383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="462" mass="49746" checksum="51606EBF55DF15DE" modified="2018-04-25" version="1">MHIRRRPSWIRTLAAPLLAASLLTACVPGMSTGVRAGATAQGPVVTSPGAIGPARLQVLDYFGGGPDKAWMTGVIEAFEKKYPQIDVSETTQNFDSIMKSLPLKLRSGSPPDIVPANNGWQSLGTLVRGNLVLDLDRYADAYGWKKSFPVSIQREHAFSPDGREMGTGPLFGTPIARGSIIEVYYNRALLKKLDAQVPKTFGEFESTLAKAKAAGVTPLSLGNVEGNGVLSGLFALTDALGDQQKIADFTYSHGDVPVRETGFREAVTTYKKWSDRGYLTKDYAAIPYADAMQSYLDGKQLFRFEYSGTLPTKPGDGDRFGSFVLPRADGGAPVATMSAASNFSISAKTKHPDAAAAFLNFAASPEAAEIAVEAGAMPMLATSRLPAGHEKLMADEVANVAQVAQDDTAVPYMDWSTPTMVNTMVQHMQDLFADKTSVPAVVAAVQDDYTKFRQEQREQMAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-05-25" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JRB3</accession>
    <name>A0A2M9JRB3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alcohol dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_23400</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000009">
        <property type="protein sequence ID" value="PJN09421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN09421">
        <property type="protein sequence ID" value="PJN09421"/>
        <property type="gene ID" value="CG723_23400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="PKS_ER"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PKS_ER" evidence="1">
        <location>
            <begin position="10"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN09421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="347" mass="35979" checksum="18DD98B508796D41" modified="2018-04-25" version="1">MKAVRLTGWGRGPAFVDVERPVPRATEVLVRVEAAGLCQSDVHVVDAAAGALPYKPPFTLGHEVAGHVEALGPDTDGPTPGERVVVYGPWGCGRCARCAAGRDNYCDRRGDLDRHGVGLGRDGGMAEYVLVPSAHYLVPIGDLAADQAAPLSDAGLTSYHAIAGVRHALGEGSTAVVIGVGGLGHLAIQILRATTPSRVLAVDIREAALALAHRSGAHASTLMRADTSRALRTGTGGVGADAVLDFVGNKATLALATEILRPGGELVVVGSGGGQLTVRKPGFLPPGFRLSLPFWGTRPELAEVVTLARAGTLHVETEQFPLSAAQTAFHRLREGAMRGRAVLVPEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JRC8</accession>
    <name>A0A2M9JRC8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_24075</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000009">
        <property type="protein sequence ID" value="PJN09402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN09402">
        <property type="protein sequence ID" value="PJN09402"/>
        <property type="gene ID" value="CG723_24075"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="164"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="35"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="39"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN09402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="191" mass="20671" checksum="A4A85C0763690548" modified="2018-04-25" version="1">MASEWISCENCGSRQRKSPAVTTCARCGVRFDPADSCDDIVDPPPPPLPPPPPPPPPPPPPPPPPPPKLESGIVEGTVRDVQTRTQHGGKDSASVFVMNFRVEEYDDSIDRVRLVPIEMKGLIFEGSVANGDRVRASGRMRSGTLRVKKLHNLTTGADVSAKSYSKIGCAVFLVFVVCMVIFIIVTSRIQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JRU6</accession>
    <name>A0A2M9JRU6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Monooxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_23075</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000008">
        <property type="protein sequence ID" value="PJN09610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN09610">
        <property type="protein sequence ID" value="PJN09610"/>
        <property type="gene ID" value="CG723_23075"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyr_redox_2" evidence="2">
        <location>
            <begin position="68"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN09610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="604" mass="66229" checksum="4889BCE31E08062D" modified="2018-04-25" version="1">MPLPQCDTPPTPQETADLRERYRVERERRVRPEGPGQYRSTAAEFGYFAADPYVDEVAEREPLHDVVDVAIVGGGFGGILAGARLRGQGVARVRVIDKGGDFGGTWYWNRYPGIHCDVESHVYLPMLDETGYVPEWKYAPGEEIRRHAMRIAERFGLYEDALFSTAVTSLAWDDSAQQWVVATDRGDKFRATYVITATGTLTEPKLPGIPGIEDYRGHTFHTSRWDYEYTGGSPKGGMTGLAGKRVAVVGTGATGVQVIPMLAEDAGHLYVFQRTPSAVDVRGQRRMTPQDVGADRAGWAAERRENFLRIVSGESAGQDLVADRWTESAGLLEKLLPSFRRDGEPDFEAAYEAADHATMNQVRERVAAEVTDPATAAALKPWYRYACKRPTFSDKYLRAFNRDNVTLVDTADTHGIERMTERGVVVGGVEYEVDCLVFATGFSVGVSGITSGNLPVTGRGGVRLLHARAQQGPRTLHGFTSAGFPNLIQMGSLQNASSVNFTHILDEQAVHAAALVTAAEEKSAVVEPTPEGEAAWIDVCAKGAPDHEWFHAECTPGYYNREGRGRPNGPTAYPHGAVAFHDLLRRWREENITDALQAKATASI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-09-29" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JS24</accession>
    <name>A0A2M9JS24_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">1-acyl-sn-glycerol-3-phosphate acyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CG723_20820</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000007">
        <property type="protein sequence ID" value="PJN09658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN09658">
        <property type="protein sequence ID" value="PJN09658"/>
        <property type="gene ID" value="CG723_20820"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002123">
        <property type="entry name" value="Plipid/glycerol_acylTrfase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01553">
        <property type="entry name" value="Acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00563">
        <property type="entry name" value="PlsC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="432"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="456"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="domain" description="PlsC" evidence="3">
        <location>
            <begin position="127"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="19"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PJN09658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="479" mass="51086" checksum="10AC267784B489B0" modified="2018-04-25" version="1">MGGRGGRRCRNCRRTLSSRRLHAGPVGRRPGRLRPRRSRRVDGEARGGREGRGQLASGLRRAPRPYRLAPRGPAPRDGGDPVTTTVTAPARVRPARAAARLRHALWWLVLTLTGGVERRGRLPRGGCVVVANHSSHADTAALLAALDASHAPAIGAAADYWFASPWRSRICSRLAAGFPVRRSGGGMDDLLGMADTLRAGHAVVLFPEGTRARAGELGSFHRGALVLAEHARVPVVPVGIAGTDRLLPKHGRLRPSLVRVRIGEPLPYTATPEEARKAVAALHDRTVAEPLRDSRARKVLARVISARLGLLLAFAWACAEALSWPLMPELFLAVACVAVPRRALKLSVTALAGSLAGGLLALQLASAGVSLPAPLTTDRMRAEVRHELSVEGASAVRHQPWNGIPLKVYAKEAGRADVPVTHWLSESARARGARTLTVGLAFGAFGFLVHRLRRLYGLYLGLLCGGFAAGLSLIVAGWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JS69</accession>
    <name>A0A2M9JS69_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Alpha-mannosidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CG723_22710</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000008">
        <property type="protein sequence ID" value="PJN09637.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN09637">
        <property type="protein sequence ID" value="PJN09637"/>
        <property type="gene ID" value="CG723_22710"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005887">
        <property type="entry name" value="Alpha_mannosidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014718">
        <property type="entry name" value="GH-type_carb-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041371">
        <property type="entry name" value="GH92_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012939">
        <property type="entry name" value="Glyco_hydro_92"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07971">
        <property type="entry name" value="Glyco_hydro_92"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17678">
        <property type="entry name" value="Glyco_hydro_92N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="SSF48208"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01180">
        <property type="entry name" value="aman2_put"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glyco_hydro_92N" evidence="3">
        <location>
            <begin position="27"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_hydro_92" evidence="2">
        <location>
            <begin position="264"/>
            <end position="752"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF17678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PJN09637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="770" mass="83734" checksum="07CD8282546DEF58" modified="2018-04-25" version="1">MATASATAGVANAKEQGPKFADDPTTLVDTSIGNNGDGTTFPGAAAPFGMVQLSPDTQLNKYASYDYAQDTILGFSHTHLSGVGCQTMGNIRFMPTTGAVTSSDPAQYGAKFSHDNETRAPGYYGVKFDNGIKAELSATQRTGQHRYTYPGGSGSENVLIEAGESNGSTYAGDVKVVGNDTVEGWVQGGNFCGETGKERYRVYFSAKFDRTFSKYGTWTDGTLTPNQREASRGTKRAGAWLTFDPAKGDQVGTSVGLSYTSIDGARLNRGAEQPKSFDKARADAHDAWRDELNRMRVAGGSTADQRTYYSALYHSLLHPSIGSDVDNRYRGFDDKVHRADSTYYQMFSLWDTYRSQNQLVALLNPDRAADMAKSVLHIYQDGGWLPRWGLGGGETNVMSGDPITPWIVDIYQRGLLDKHTSHQLFDALWKNANEVPTDQSVFRGRDGNPSYVKNGWVGYQNLPGYLYGDSRQSGSATLEYALGDCALSTMAGDLGYQDKAATLASRCDNFAKLWDPSVTSQGFSGFPVAKNEDGTVAGDPDPTQAGAFHEGTAWQYQWLAQQDPQTLFRLMGGQAAAEQRLDKFFDMPTVLTDPAKAASESWVSGAYDYHNNFAFNPNNEPDFHTPWMYSWTGAPWKTSAVLRAMRTLFTDDAYGMPGNDDLGATSSLLVFAMAGVFEAQPGSANYIVTAPMFEKVEIRPEHGSKINIEAPGADASKLQYVSSVHTGKGTLHQSWLSHKDLLRAGTIRIGLSDKPTTWGVSTAPPAINQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JSF9</accession>
    <name>A0A2M9JSF9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_21580</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000007">
        <property type="protein sequence ID" value="PJN09788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN09788">
        <property type="protein sequence ID" value="PJN09788"/>
        <property type="gene ID" value="CG723_21580"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012467">
        <property type="entry name" value="DUF1684"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41913">
        <property type="entry name" value="PTHR41913"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07920">
        <property type="entry name" value="DUF1684"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN09788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="240" mass="26621" checksum="CE6687CED89F7516" modified="2018-04-25" version="1">MSAAMPDRASDPSQAWEEWRAERHRSVTGATGNLALVETRWLPAGERPDLTAARAGQRDGVTVTTVERTDLATGEPEYALRFWDAESPAIRDFERTDAFPFDPAWVLDATYTPVEDARRVAFEHIRDNGGTRDLAVPGDIALTVDGTDYTLSAFDDDGTLLLVFGDPTNGTVTYGAGRFLFVEHTGEGRVRLDFNRAFVPPCGFSDQYNCPMPPRQNRFHLPVEAGEKLPVFRDGFADQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JSM7</accession>
    <name>A0A2M9JSM7_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Peptidase_M23 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_21360</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000007">
        <property type="protein sequence ID" value="PJN09853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN09853">
        <property type="protein sequence ID" value="PJN09853"/>
        <property type="gene ID" value="CG723_21360"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.70.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011055">
        <property type="entry name" value="Dup_hybrid_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016047">
        <property type="entry name" value="Peptidase_M23"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01551">
        <property type="entry name" value="Peptidase_M23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51261">
        <property type="entry name" value="SSF51261"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014598676" description="Peptidase_M23 domain-containing protein" evidence="1">
        <location>
            <begin position="22"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M23" evidence="2">
        <location>
            <begin position="46"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN09853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="239" mass="23840" checksum="F166AC7BA08F32F3" modified="2018-04-25" version="1">MLTMTAALAGLAPPPPVPAVGAAWPVGTRPPILRGWAPPATDYGAGHRGVDLAAPVGTSVRAVARGRVSFAGRVAGRGVVAVELSETGDPPLRTTYEPVTPSVKKGARVAPGEVLGVLEPATNHCGPTSCLHWGLLRGDTYLDPLSLLPPRLLRQGPSRLLPVLGAGGSGAGTGGTPWADPPLPVPLPPVRSAVRADGVMAGAPRTFSPLLPDGAMADAGTAMGAAPGPVPLALGPAEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JSN7</accession>
    <name>A0A2M9JSN7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_21780</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000007">
        <property type="protein sequence ID" value="PJN09863.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN09863">
        <property type="protein sequence ID" value="PJN09863"/>
        <property type="gene ID" value="CG723_21780"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="122"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN09863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="156" mass="16671" checksum="9EAA2A7587F27DBF" modified="2018-04-25" version="1">MAMGGVSAAAAANLEVSGELLKDFQKRVDALLADFEGSAGNATKVGSQTISRASFSDGSGAFHEADHLYSQYNRVHGHLTALSKSLSLQIEATGIAVLGAKNGFANLDEDLRHRFWEIQTQLSEQQSQQREAAQAEKDGKTAPKQSDNTKSTVGYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JSU7</accession>
    <name>A0A2M9JSU7_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 6 9">Malate dehydrogenase</fullName>
            <ecNumber evidence="3 6 9">1.1.1.37</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">mdh</name>
        <name evidence="13" type="ORF">CG723_19725</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">CB01635</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the reversible oxidation of malate to oxaloacetate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6 9">
            <text>(S)-malate + NAD(+) = H(+) + NADH + oxaloacetate</text>
            <dbReference type="Rhea" id="RHEA:21432"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15589"/>
            <dbReference type="ChEBI" id="CHEBI:16452"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.37"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the LDH/MDH superfamily. MDH type 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.37" evidence="3 6 9"/>
    <dbReference type="EMBL" id="NNBL01000006">
        <property type="protein sequence ID" value="PJN09959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN09959">
        <property type="protein sequence ID" value="PJN09959"/>
        <property type="gene ID" value="CG723_19725"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030060">
        <property type="term" value="F:L-malate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006108">
        <property type="term" value="P:malate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01517">
        <property type="entry name" value="Malate_dehydrog_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001557">
        <property type="entry name" value="L-lactate/malate_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022383">
        <property type="entry name" value="Lactate/malate_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001236">
        <property type="entry name" value="Lactate/malate_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015955">
        <property type="entry name" value="Lactate_DH/Glyco_Ohase_4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001252">
        <property type="entry name" value="Malate_DH_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010945">
        <property type="entry name" value="Malate_DH_type2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23382">
        <property type="entry name" value="PTHR23382"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02866">
        <property type="entry name" value="Ldh_1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00056">
        <property type="entry name" value="Ldh_1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000102">
        <property type="entry name" value="Lac_mal_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56327">
        <property type="entry name" value="SSF56327"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01759">
        <property type="entry name" value="MalateDH-SF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00068">
        <property type="entry name" value="MDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0520">NAD</keyword>
    <keyword evidence="5 6 10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="Ldh_1_N" evidence="11">
        <location>
            <begin position="7"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="domain" description="Ldh_1_C" evidence="12">
        <location>
            <begin position="157"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="6 7">
        <location>
            <position position="188"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="12"/>
            <end position="18"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="93"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6 8">
        <location>
            <position position="99"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="106"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="113"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="130"/>
            <end position="132"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6 8">
        <location>
            <position position="132"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6 8">
        <location>
            <position position="163"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00020382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000102-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000102-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003369"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF02866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PJN09959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="330" mass="34634" checksum="982393E027A69A90" modified="2018-04-25" version="1">MTRTPVNVTVTGAAGQIGYALLFRIASGQLLGADVPVNLRLLEITPALKAAEGTAMELDDCAFPLLQNIEISDDPNVAFDGANVALLVGARPRTKGMERGDLLSANGGIFKPQGKAINDNAADDIKVLVVGNPANTNALIAQAAAPDVPAERFTAMTRLDHNRALTQLAKKTGTTVADIKRLTIWGNHSATQYPDIFQASVAGKPAIEAIGGDEQWLAEAFIPTVAKRGAAIIEARGASSAASAANAAIDHVHTWVNGTAEGDWTSMGIPSDGSYGVPEGLISSFPVTTKDGKYEIVQGLDINEFSRARIDASVKELEEERAAVRELGLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JT39</accession>
    <name>A0A2M9JT39_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_19660</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000006">
        <property type="protein sequence ID" value="PJN09947.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN09947">
        <property type="protein sequence ID" value="PJN09947"/>
        <property type="gene ID" value="CG723_19660"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="85"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN09947.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="286" mass="31617" checksum="6332B6F4014116AB" modified="2018-04-25" version="1">MSEPRHEDDGSHGPGKEHGPRAGRGLPDELRALGRSLDGLGPGGESMAERVLAQILAESVPAPVAEPEAAPARVRRARRWIRKRWRMLTAGMCGVLTVLVLTPPVRAAVADWFGFGGVEVRYDPSALPSGAHVPGCGTSLSLGEARREAGFEPLVPDELGMPDVVTVTREPKSRFLITLCWREDGHTIRLDEYPAQLDIGYTKSVRMQPRWVGLGPDTGLWFAQPHLLSFWMLDGNGDRWTRSERTAGPTLLWTRRQQVTLRLEGIDSQQRAMEIARSVRKPDAVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JTF0</accession>
    <name>A0A2M9JTF0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_19680</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000006">
        <property type="protein sequence ID" value="PJN10143.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN10143">
        <property type="protein sequence ID" value="PJN10143"/>
        <property type="gene ID" value="CG723_19680"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014967909" evidence="2">
        <location>
            <begin position="25"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="45"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="70"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="98"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="129"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="157"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="190"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="216"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="246"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN10143.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="281" mass="27715" checksum="D6F6E931285B91A2" modified="2018-04-25" version="1">MVCALGAAVCFGTASVLQAMAARASEPGSGSGVDAALLLRALRQWRYVAGLGLDLLGFVLQVVALRSIPIYAVGAALAASLAVTAVVASRLLDVRLSAVEWGAVGVVVAGLAMLGLASGTEGDKAGSDALRYAMLGTALGVLLIGAVAGRLPGRGRALALGLGSGFGFGVVEVSVRLIDDVSPGALLSNPATYALLLGGGSAFLLLTSALQKGSVTTATAGMVVGETVGPALVGVIWLGDRTREGLAWLAVLGFVVAVAGALALARFGEAPVGDPSAPARV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JTS5</accession>
    <name>A0A2M9JTS5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CG723_17455</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000005">
        <property type="protein sequence ID" value="PJN10187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN10187">
        <property type="protein sequence ID" value="PJN10187"/>
        <property type="gene ID" value="CG723_17455"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PJN10187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="94" mass="9899" checksum="E9625A623B460EE9" modified="2018-04-25" version="1">MLAGDPVIQAIITGELAELRRRLLEATVLGDGPTHLVSAALTSWPVFVRVLCVDRLTNESFTRAELHGMCVGALKGALGAVLDLDALTGMEGGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-05-25" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JTZ1</accession>
    <name>A0A2M9JTZ1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">tRNA-specific adenosine deaminase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CG723_18415</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000005">
        <property type="protein sequence ID" value="PJN10350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN10350">
        <property type="protein sequence ID" value="PJN10350"/>
        <property type="gene ID" value="CG723_18415"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008251">
        <property type="term" value="F:tRNA-specific adenosine deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002100">
        <property type="term" value="P:tRNA wobble adenosine to inosine editing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016192">
        <property type="entry name" value="APOBEC/CMP_deaminase_Zn-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002125">
        <property type="entry name" value="CMP_dCMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016193">
        <property type="entry name" value="Cytidine_deaminase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028883">
        <property type="entry name" value="tRNA_aden_deaminase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14437">
        <property type="entry name" value="MafB19-deam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53927">
        <property type="entry name" value="SSF53927"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00903">
        <property type="entry name" value="CYT_DCMP_DEAMINASES_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51747">
        <property type="entry name" value="CYT_DCMP_DEAMINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="CMP/dCMP-type deaminase" evidence="3">
        <location>
            <begin position="1"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PJN10350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="165" mass="18781" checksum="AFF0FC361D991C15" modified="2018-04-25" version="1">MDFAQRTIDLARQNVEEGGRPFATVIVRDGEILAESPNRVAQTSDPTAHAEILAIRDACRKLGTEHLVGATIYVLAHPCPMCLGSLYYCSPDEVVFLTTRDAYEPHYVDDRKYFELDTFYGEFAKDYTERRLPMRHEPRDNAVDVYRLWQERNGGSRRVPGAPTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JUF8</accession>
    <name>A0A2M9JUF8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CG723_19130</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CB01635</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000005">
        <property type="protein sequence ID" value="PJN10468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN10468">
        <property type="protein sequence ID" value="PJN10468"/>
        <property type="gene ID" value="CG723_19130"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001851">
        <property type="entry name" value="ABC_transp_permease"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02653">
        <property type="entry name" value="BPD_transp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="27"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="51"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="83"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="107"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="134"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="174"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="225"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="307"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PJN10468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="333" mass="33653" checksum="56483A96B1DE80C0" modified="2018-04-25" version="1">MTGTAVAPPPVAKSAPPRRIRLADPAVGVWLAAAAVTAAGWIVVAARGGDFLTLANVVGILQNCVALGLVAVGQTAVILSGSLDLSVAYLISLGTLVAATTMEDGSLVTAVLAVLALSAAVGLANGLVVTGLKVNAFIATLGTAFILRGWIEDNYTGPAGKVPASFQHLGYDRIGPVPVSVFLLAAVAAALWLVTRRTRFGHHLYATGGDEHAARLSGVRTRRTVVAAHVLCSLCVGAAALFLAARLGAGAPWAGTEARYDLESIAAVVLGGTALAGGRGGVAGTLGGVLVLAVLDSVFNQLGVDPFFKNVVRGVVIIAAVALYARRGTRRTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JUN5</accession>
    <name>A0A2M9JUN5_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Nitrile hydratase</fullName>
            <ecNumber evidence="3">4.2.1.84</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">nthA</name>
        <name evidence="8" type="ORF">CG723_15275</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CB01635</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>an aliphatic amide = a nitrile + H2O</text>
            <dbReference type="Rhea" id="RHEA:12673"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:18379"/>
            <dbReference type="ChEBI" id="CHEBI:65285"/>
            <dbReference type="EC" id="4.2.1.84"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the nitrile hydratase subunit alpha family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.84" evidence="3"/>
    <dbReference type="EMBL" id="NNBL01000004">
        <property type="protein sequence ID" value="PJN10579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN10579">
        <property type="protein sequence ID" value="PJN10579"/>
        <property type="gene ID" value="CG723_15275"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080109">
        <property type="term" value="F:indole-3-acetonitrile nitrile hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046914">
        <property type="term" value="F:transition metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006807">
        <property type="term" value="P:nitrogen compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.330.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036648">
        <property type="entry name" value="CN_Hdrase_a/SCN_Hdrase_g_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004232">
        <property type="entry name" value="CN_Hdrtase_a/SCN_Hdrlase_g"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023900">
        <property type="entry name" value="CN_Hdrtase_asu/SCN_Hdrlase_gsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018141">
        <property type="entry name" value="Nitrile_hydratase_asu"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02979">
        <property type="entry name" value="NHase_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001426">
        <property type="entry name" value="NHase_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56209">
        <property type="entry name" value="SSF56209"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01323">
        <property type="entry name" value="nitrile_alph"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0456">Lyase</keyword>
    <keyword evidence="4 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NHase_alpha" evidence="7">
        <location>
            <begin position="12"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="104"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="107"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="108"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="109"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001410"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR001426-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PJN10579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="196" mass="21024" checksum="803935A2C64DBE8D" modified="2018-04-25" version="1">MMSGTHEDAVISRQVRRLESLLETRGIVGGDTVDEVIDGFLAGASPVNGAKVVARAWADPAYRERLLADGTAAVGELGFAAGGVQKQRLRVVENTADTHNVIVCTLCSCYPLRLLGPSPGWYKSEAYRSRVVRDPRGVLAEFGVTLPETVDITVWDSSAETRYMVLPRRPAGTDRLSEAALASLITRNGLIGTGVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JUQ5</accession>
    <name>A0A2M9JUQ5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Methionine ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CG723_15450</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000004">
        <property type="protein sequence ID" value="PJN10610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN10610">
        <property type="protein sequence ID" value="PJN10610"/>
        <property type="gene ID" value="CG723_15450"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="6"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="51"/>
            <end position="58"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PJN10610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="329" mass="36982" checksum="8DD0B0BD55417F99" modified="2018-04-25" version="1">MTEDFIEVDGVEKVFDVRRKTGLLRRERHQVRAVDSLTFSVPRGEMVGYIGPNGAGKSTTIKMLTGILTPSAGRLRVAGIEPSRERTRLARRIGVVFGQRTTLWWDLPLIDSYRLMHRMYRIPDVRYRENLDRCVELLELGGLLDTPVRQLSLGQRMRGDIAAALLHDPEVLYLDEPTIGLDVVSKVKVRGFLRELNEERGTTVLLTTHDLTDIEQLCKRVMVIDHGRLMYDGQLTGLHQVGESERTLVVDLERELPPLEVQFARVVKVDGPRQWLAFPAAQSAAPLVAQIAAQYPLVDLSVREPDIESVIARMYAREEPSLGGTAAPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JV96</accession>
    <name>A0A2M9JV96_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_16555</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000004">
        <property type="protein sequence ID" value="PJN10789.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN10789">
        <property type="protein sequence ID" value="PJN10789"/>
        <property type="gene ID" value="CG723_16555"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="61"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN10789.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="81" mass="8082" checksum="33D4FBA4D36AFDA1" modified="2018-04-25" version="1">MAASAHLLLSALSKQADVILPAPALPLPDEFAFGAELPLTSEPPLADTEPLTSEPALIDVAPLTSEPTPSGPVAGLDASGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-09-29" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JVB0</accession>
    <name>A0A2M9JVB0_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Acyl_transf_3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CG723_16735</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000004">
        <property type="protein sequence ID" value="PJN10821.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN10821">
        <property type="protein sequence ID" value="PJN10821"/>
        <property type="gene ID" value="CG723_16735"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002656">
        <property type="entry name" value="Acyl_transf_3_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01757">
        <property type="entry name" value="Acyl_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014889850" description="Acyl_transf_3 domain-containing protein" evidence="3">
        <location>
            <begin position="29"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="43"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="73"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="106"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="137"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="167"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="191"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="220"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="259"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="291"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="329"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl_transf_3" evidence="4">
        <location>
            <begin position="42"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PJN10821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="382" mass="43489" checksum="86DE3094A79674E4" modified="2018-04-25" version="1">MFRAAPTRAPLPAAQTAPAHQPPNTAAAPPTPAAKPAKQRDAFFDNAKYLAIVLVAMGHSWEPLTDHSRAAEALYMTVYTFHMPAFIVISGYFSRSFDMRPDRLRRLITGVAVPYVIFEVAYTFFKRWADDDPTQPFSLLDPWYLTWFLVALFVWRLTTPLWKIVRWPVPLAVAIAVLASVSPDIGDDLDLQRVLQFLPFFVLGLFLKPEHFQLVRRREVRILSVPIFAVALVLAYWAAPRMTSAWFYHRDSAQELGAPWWAGAVMTFALFGCSVVLTACFFAWVPRRKMWFTVLGAGTLYGYLLHGFIAKGSRFWGWFDDYAWLHKPLGEVFVTVVAASLITVLCTPPVQRMFRFAMEPKMEWAFKKDAAEVARDRGRARA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JVG7</accession>
    <name>A0A2M9JVG7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DNA-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CG723_16995</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000004">
        <property type="protein sequence ID" value="PJN10864.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN10864">
        <property type="protein sequence ID" value="PJN10864"/>
        <property type="gene ID" value="CG723_16995"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010994">
        <property type="entry name" value="RuvA_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019554">
        <property type="entry name" value="Soluble_ligand-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10531">
        <property type="entry name" value="SLBB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47781">
        <property type="entry name" value="SSF47781"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="185"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="domain" description="SLBB" evidence="3">
        <location>
            <begin position="266"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="18"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="62"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="216"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="325"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="72"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF10531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PJN10864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="415" mass="41874" checksum="27616E31C19FEB79" modified="2018-04-25" version="1">MAFGPALSETAVRSETLEAAAGDVAPGGASGTWQRRRRVRRRYRQASAEALRLRAEALFAEGRGGPPGWSGAPSLSPGPPGVPSSPDPPEWVRPSLPRWAGTVSSRPPRWARADADADADADADVDSDDGGVWVAGVAPGEFTGERDEPAGEAERAPSWRERAGLAVRERLPLWMQTRCGLERRSVIALVVVLVAAAGFAVHHFWTGRAQPVSAPEVVRSAAPEGAAGQLDAGQEPGAGPSAPAPAGPSAAGGTDGPAGAAAAGIVVDVSGKVRSPGIHRLPAGSRVADALRAAGGIRPGVDPTGINRARLLADGEQVVVGAPAAPGGTGAGGSAGSASSAGTGAGTGAAAAGPIGLNTATAEQLDTLPGVGPVLAQHIIDYRTEHGGFRSIDELREVNGIGDRRFSDLQNLVRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JVU6</accession>
    <name>A0A2M9JVU6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Gas vesicle protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CG723_08455</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN11016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN11016">
        <property type="protein sequence ID" value="PJN11016"/>
        <property type="gene ID" value="CG723_08455"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007804">
        <property type="entry name" value="Gas-vesicle_GvpG"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05120">
        <property type="entry name" value="GvpG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PJN11016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="83" mass="9526" checksum="DF0CB055A9E0F44E" modified="2018-04-25" version="1">MGLLTQILTLPLAPVRGVVWVADRVLEAAEDKYYDPAPVHRELAELERRLLDGEIDEATFDEREDELLDRLDEIKARRDRGAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JVV2</accession>
    <name>A0A2M9JVV2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alkaline shock response membrane anchor protein AmaP</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_08335</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN11000.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN11000">
        <property type="protein sequence ID" value="PJN11000"/>
        <property type="gene ID" value="CG723_08335"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="68"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN11000.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="200" mass="21314" checksum="E08F25B3869EFCD8" modified="2018-04-25" version="1">MNGRSTLNRLLLSLCGLVLLGGGLLILTAGFDLYRRLHVAPPAGWPVAAPHEVLLSNTDRVHWSDQGWWWAAVIAVLVLAAALALIWLLAQRRHRPSAVHLGGTPPPESVELRGRALSDAVTSEARALPDVKQAGAHLTGRAAGPQLHVALTLTDHGLPAPVLQALCHGPVAHAREATGLTRLPARAHLNVGRHKARRAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JW54</accession>
    <name>A0A2M9JW54_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 6">Extracellular small neutral protease</fullName>
            <ecNumber evidence="4 6">3.4.24.77</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CG723_08795</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CB01635</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>Hydrolyzes proteins with a preference for Tyr or Phe in the P1' position. Has no action on amino-acid p-nitroanilides.</text>
            <dbReference type="EC" id="3.4.24.77"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
        <text evidence="8">Binds 1 Ca(2+) ion per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="8">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 6">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 6">Belongs to the peptidase M7 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.77" evidence="4 6"/>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN11062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN11062">
        <property type="protein sequence ID" value="PJN11062"/>
        <property type="gene ID" value="CG723_08795"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000013">
        <property type="entry name" value="Peptidase_M7"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02031">
        <property type="entry name" value="Peptidase_M7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016573">
        <property type="entry name" value="Peptidase_M7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00787">
        <property type="entry name" value="NEUTRALPTASE"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0106">Calcium</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="6" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0964">Secreted</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="6 8" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014495383" description="Extracellular small neutral protease" evidence="6">
        <location>
            <begin position="33"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="active site" evidence="7">
        <location>
            <position position="166"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="158"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="165"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="169"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="175"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="181"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00019129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR016573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR016573-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR016573-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR016573-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PJN11062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="227" mass="23527" checksum="1585A8007DEE11C1" modified="2018-04-25" version="1">MKSSRTSARTLAIVLGLGLASSALGAAVPASAQTAATPSAAAGTSVARYAGSVKETANNKAFFDAVLKSVAEKRAAQPNAQAVTVYYNASQAPSFRSQISSAASIWNSSESNVKLQATSSGADFSYREGNDPDGSYASTNGHGDGYIFLDYTQSRQNDSVRVATHETGHVLGLPDNYSGPCSELMSGGGPGPSCTSHYPNATERSRVDQLWATGLAQAPHSGRTWAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JW83</accession>
    <name>A0A2M9JW83_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_09340</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN11151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN11151">
        <property type="protein sequence ID" value="PJN11151"/>
        <property type="gene ID" value="CG723_09340"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN11151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="67" mass="7158" checksum="7648932722757549" modified="2018-04-25" version="1">MRPLLCTKYGPPLPPEGTEAGIGGTNTGTGEYLEEASGGRMTVVCADPEVVVDDRRPVLRLRESREG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JWE5</accession>
    <name>A0A2M9JWE5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Muconolactone delta-isomerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_09320</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN11148.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN11148">
        <property type="protein sequence ID" value="PJN11148"/>
        <property type="gene ID" value="CG723_09320"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026029">
        <property type="entry name" value="MLI_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02426">
        <property type="entry name" value="MIase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MIase" evidence="2">
        <location>
            <begin position="1"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="domain" description="MIase" evidence="2">
        <location>
            <begin position="107"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="83"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02426"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN11148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="201" mass="21721" checksum="700031F18CBA3386" modified="2018-04-25" version="1">MEHLVTMTTHVPEGTSQAEVDEVRAREAAHSRRLAERGQLLRLWRPPLHPGEWRTLGLFAAQDAAHLEDVLSSMPLRVWRSDEVTPLTPHPNDPGPASTGASGAAKEFLVTFAPAATEDATSQALGDATAAEAVRAKELAGQGHLVRLWKTPGERRALGLWRARDAAEMQTVLDSLPQAPWLSMETTPLSEHPSDPGAVGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JWI3</accession>
    <name>A0A2M9JWI3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CG723_09070</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN11107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN11107">
        <property type="protein sequence ID" value="PJN11107"/>
        <property type="gene ID" value="CG723_09070"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030638">
        <property type="term" value="P:polyketide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009959">
        <property type="entry name" value="Cyclase_SnoaL-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07366">
        <property type="entry name" value="SnoaL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="SSF54427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PJN11107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="157" mass="16942" checksum="BA1FAAB35A7EC545" modified="2018-04-25" version="1">MSELAQALATAKSRQDVPAAMELFHRDMVLDAPAFGTRAQGRAANERALTGFFASFPDYQVALEGHAADGDALVCWGTVKMTMTGDRFGVHPNGRRAELPVFIQFAFKDGLIAGERFFFDLSELCAQSGVSTDAVRRKLFGAAAFAPSTPGIEPIQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JWV7</accession>
    <name>A0A2M9JWV7_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Alpha-L-rhamnosidase</fullName>
            <ecNumber evidence="2">3.2.1.40</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CG723_10660</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CB01635</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal non-reducing alpha-L-rhamnose residues in alpha-L-rhamnosides.</text>
            <dbReference type="EC" id="3.2.1.40"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.40" evidence="2"/>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN11376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN11376">
        <property type="protein sequence ID" value="PJN11376"/>
        <property type="gene ID" value="CG723_10660"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030596">
        <property type="term" value="F:alpha-L-rhamnosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016007">
        <property type="entry name" value="Alpha_rhamnosid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035396">
        <property type="entry name" value="Bac_rhamnosid6H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035398">
        <property type="entry name" value="Bac_rhamnosid_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013737">
        <property type="entry name" value="Bac_rhamnosid_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008902">
        <property type="entry name" value="Rhamnosid_concanavalin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05592">
        <property type="entry name" value="Bac_rhamnosid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17389">
        <property type="entry name" value="Bac_rhamnosid6H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17390">
        <property type="entry name" value="Bac_rhamnosid_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08531">
        <property type="entry name" value="Bac_rhamnosid_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF010631">
        <property type="entry name" value="A-rhamnsds"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="SSF48208"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="SSF49785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014857726" description="Alpha-L-rhamnosidase" evidence="4">
        <location>
            <begin position="31"/>
            <end position="1071"/>
        </location>
    </feature>
    <feature type="domain" description="Bac_rhamnosid_N" evidence="6">
        <location>
            <begin position="357"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="domain" description="Bac_rhamnosid" evidence="5">
        <location>
            <begin position="536"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="domain" description="Bac_rhamnosid6H" evidence="7">
        <location>
            <begin position="641"/>
            <end position="971"/>
        </location>
    </feature>
    <feature type="domain" description="Bac_rhamnosid_C" evidence="8">
        <location>
            <begin position="973"/>
            <end position="1044"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012652"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF05592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF17389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF17390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PJN11376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="1071" mass="114988" checksum="427D4BFCCA30D9EA" modified="2018-04-25" version="1">MISRRRLLSTTATAALGTAIASAAPGAAQAAPASGAAARTRAAKAVRVSAPTVEYVRHPLGLDVPHPRLSWPLVSDEPGRAQSACQIRVATTASRLGDPDVWDSGKVDSPESTLVPYAGPALAARTRYYWTVRIWDTTGRASEWSEPSWWETGLTAASDWSARWIGAPAALIGTPALDDASWIWFPEGDPAAGAPAGTRYFRGRADVPEGLTRARLVMTADDGYTAYVNGTEVAHADPDGPAENWRRPAVVDVTAQLRSGSAVLSVAAVNATDSPAGLLGLLELTTADGVKIFATGADWKAADQEPAGDWKSAGFDDSSWKAAKALAKWGSGPWGKVAPSHSPAAQLRHEFRLKGRSVARARLYASALGLYEAHINGERVGEDRLAPGWTDYRKRVQYQTYDVTKLVKSGANALGATVAAGWYAGNIAWFGPHQYGERPAFLAQLEVTYTDGSTERVLSGTDWHASTGPVTEADLMAGEEYDARLETDGWTRAGFDDSGWVAATAVDKVSAALVAEAGGPTRLERELPARKMTEPKPGVFVYDLGQNMVGAVRLTVAGKAGTTVRLRHAEVLNPDGTIYTANLRTAKATDTYTLKGGGKETYEPRFTFHGFRYVEVTGYPGKPPLDAVVGRVIHTSAPFTMDFSTNVPMLNQLHQNITWGQRGNFVSIPTDTPARDERLGWTGDINVFAPTAAYNMESARFLTKWLGDLRDGQSDEGAFTNVAPDMPGVGNGVAGWGDAGVTVPWALYQAYGDMRVLEQSWASMLKWLDYLEKHSSGFLRPAEGFGDWLNLQDETPKDVIGTAYFAHAADLVARAAKALGKDPAPYTSLFGSVRDAFRAAYVSDGGKVKGDTQTAYVLALSMDLLAQADRGPAADRLVALIKAKDWHLSTGFLGTPRLLPVLTAAGHTDVAYRLLVQRSFPSWGYQIDRGATTMWERWDSIRPDGSFQDAGMNSFNHYAYGSVGEWMYANIAGIAPAEPGFRKILVRPRPGGGITRAEGRYDSVQGPISTKWSVDSDGFRLTLTVPANTTAEVWIPASDAAEVAHGAAKFLRMDDGCAVFAAASGTHRFSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JXR6</accession>
    <name>A0A2M9JXR6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MarR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_12460</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN11675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN11675">
        <property type="protein sequence ID" value="PJN11675"/>
        <property type="gene ID" value="CG723_12460"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000835">
        <property type="entry name" value="HTH_MarR-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12802">
        <property type="entry name" value="MarR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00598">
        <property type="entry name" value="HTHMARR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00347">
        <property type="entry name" value="HTH_MARR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50995">
        <property type="entry name" value="HTH_MARR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH marR-type" evidence="1">
        <location>
            <begin position="7"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN11675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="144" mass="15657" checksum="DD9DDB259843E4FF" modified="2018-04-25" version="1">MAKNGGRRDLAAMLQPLVRSLIAAELPVLASHGISMWGYVVLSALDDGPVRTQAALATAIGADKTRIISTLDTLQESGLISRTPDPHDRRVRLLSITDDGRRLRRSAQADIHAHEDRLLARLPAADRRVFLDAVHTLTPDADTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-06-02" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JXS3</accession>
    <name>A0A2M9JXS3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_12530</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN11686.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN11686">
        <property type="protein sequence ID" value="PJN11686"/>
        <property type="gene ID" value="CG723_12530"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="30"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN11686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="83" mass="9081" checksum="56ED21288DDB7755" modified="2018-04-25" version="1">MVGLPSGTRFRRTPAGGAIMSKKQSRHNRGARSGGHDHDRSAPAAEKKSTPEPITKATDPSEEPARRISEHHSHKPPRKFGHN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JXY9</accession>
    <name>A0A2M9JXY9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">AraC family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_12880</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN11746.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN11746">
        <property type="protein sequence ID" value="PJN11746"/>
        <property type="gene ID" value="CG723_12880"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035418">
        <property type="entry name" value="AraC-bd_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037923">
        <property type="entry name" value="HTH-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14525">
        <property type="entry name" value="AraC_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51215">
        <property type="entry name" value="SSF51215"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="2">
        <location>
            <begin position="197"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="139"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN11746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="297" mass="30961" checksum="7CE41AA753E5C18E" modified="2018-04-25" version="1">MRVSATDLRETAAPPSGVLIVGRYDGQPDYAVRRKAGAPSWLLLWTESGAGHVRQGGAGTVAGPGSLVLLAPGVHHTYRTAPDAEHWGLWWAHFLLRPGWEQRLRPYDLGSGCHVMPDVHPGARTGVAAALRQAHADSRWTGAGAPPRPVSATRRTVPASVATGPDAAALALGSVERALLLATSPSGVTGPGDARVRRAQALIDADPAAAHTVDSLAAAVALSPSRFAHLFAEETGSTPMRALREARLQHAACLLTGTELTVAQVAAASGFAGPFHFSHAFRGRYGSPPKEYRSAAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JY44</accession>
    <name>A0A2M9JY44_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Catechol 1,2-dioxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_13135</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN11789.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN11789">
        <property type="protein sequence ID" value="PJN11789"/>
        <property type="gene ID" value="CG723_13135"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008687">
        <property type="term" value="F:3,4-dihydroxyphenylacetate 2,3-dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008198">
        <property type="term" value="F:ferrous iron binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006725">
        <property type="term" value="P:cellular aromatic compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07370">
        <property type="entry name" value="HPCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011984">
        <property type="entry name" value="HPCD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004183">
        <property type="entry name" value="Xdiol_dOase_suB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02900">
        <property type="entry name" value="LigB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LigB" evidence="1">
        <location>
            <begin position="9"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN11789.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="314" mass="35258" checksum="565EA3540FAFD50F" modified="2018-04-25" version="1">MGEIVGAGLLAHVPTVVLPQETRLELNEGKEITLVTGLKELRREVFERDASQEYDTVVVLDSHWATTVEFVVTGQQRRAGLFTSEELPRGMCRMPYDFPGDPELAENIAGFADKHGTWITAIDDPYLPIYYATTNLWKFLGEGLPDKKWVTIGVCQTGDMEDHLRLGRALADGIAATPGRRVLLIASGALSHTFWPLRQLRDHESSDPAHIFTAEAREADHERIGWFKEGRHDKVLDTMDEFWKFKPEAKFFHYLMMAGALGERACVARARQYGEYENSIGTGQVHLWFDRPAGGWTGNGLPAHPVPHNPHSRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JYS5</accession>
    <name>A0A2M9JYS5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Acetolactate synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CG723_14600</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CB01635</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the TPP enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN12033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN12033">
        <property type="protein sequence ID" value="PJN12033"/>
        <property type="gene ID" value="CG723_14600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030976">
        <property type="term" value="F:thiamine pyrophosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012000">
        <property type="entry name" value="Thiamin_PyroP_enz_cen_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012001">
        <property type="entry name" value="Thiamin_PyroP_enz_TPP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045229">
        <property type="entry name" value="TPP_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011766">
        <property type="entry name" value="TPP_enzyme-bd_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18968">
        <property type="entry name" value="PTHR18968"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02775">
        <property type="entry name" value="TPP_enzyme_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00205">
        <property type="entry name" value="TPP_enzyme_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02776">
        <property type="entry name" value="TPP_enzyme_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="SSF52467"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0786">Thiamine pyrophosphate</keyword>
    <feature type="domain" description="TPP_enzyme_N" evidence="5">
        <location>
            <begin position="1"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="domain" description="TPP_enzyme_M" evidence="3">
        <location>
            <begin position="185"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="domain" description="TPP_enzyme_C" evidence="4">
        <location>
            <begin position="384"/>
            <end position="525"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU362132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PJN12033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="544" mass="57532" checksum="743F3C8DE0F44F5A" modified="2018-04-25" version="1">MKVAEAVGRALAAAGVDHVFGVVGSGNFHLTNALVAAGSRYVAARHEGGAATMADAYARMSGKVAALSVHQGCGLTNALTGIAEAAKSRTPLLVLAAETAETTSNFYVDQDALARSVGAVSARVTSAEDAVEQACAAVRRALHERRTVVLNLPLEIQALDVSEGASVTPPPERTSVEPESGAVVQLVQTLERAQRPVFVAGRGARTPDARDALAALAERHGALLATSAVARGLFHDNPWSLDVSGGFSSPLTAELVKGADLIVGWGCALNMWTMRQGRLIGPEATVVQVDDDPSALGRHRTVHLGIIGDVERTARRALEASGGRRTGYRTPTIGESIAARVRWRDVSYEDESSHERIDPRTLSIALDDLLPAERVIGVDSGNFMGYPSMFLSVPDHNSLCFTQAFQSIGLGLSTAIGAALARPDRLPVAALGDGGALMSAVELDTVRRLGLPMVVVVYNDDAYGAEVHHFAPGQFPLDTVEFPPTDIAAIARGYGFEAVTVRTRADLEPVRDWVAGPRSTPLLIDAKVTSEHGSWWLEEAFRGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JZP5</accession>
    <name>A0A2M9JZP5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">FmdB family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_04655</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000002">
        <property type="protein sequence ID" value="PJN12349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN12349">
        <property type="protein sequence ID" value="PJN12349"/>
        <property type="gene ID" value="CG723_04655"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013429">
        <property type="entry name" value="Regulatory_FmdB_Zinc_ribbon"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09723">
        <property type="entry name" value="Zn-ribbon_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00834">
        <property type="entry name" value="CxxC_CXXC_SSSS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02605">
        <property type="entry name" value="CxxC_CxxC_SSSS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CxxC_CXXC_SSSS" evidence="1">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN12349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="75" mass="7255" checksum="BC83AC9C848784C5" modified="2018-04-25" version="1">MPRYEYRCRTCGDTFELSRPMAESSAPADCPAGHDDTVKLLSTVAVGGTTSAAAPARPAGGGGGGGGCCGGGCCG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JZQ0</accession>
    <name>A0A2M9JZQ0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Tellurium resistance</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CG723_04630</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000002">
        <property type="protein sequence ID" value="PJN12344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN12344">
        <property type="protein sequence ID" value="PJN12344"/>
        <property type="gene ID" value="CG723_04630"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06974">
        <property type="entry name" value="TerD_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003325">
        <property type="entry name" value="TerD"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PJN12344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="246" mass="27579" checksum="C2E0E2A09E525A9E" modified="2018-04-25" version="1">MSFWDGLWRGRAADFESGSAASNSIELTKRHPVVSLTKQGAATGNLRINLSWRMRTSDIGGPERESLLRHPFKLFKPDVVQAHTQSMVNVDLDLGCLYELTDGEKGVVQPLGSFFGALNAPPYVKLSGDDRFGSASGETIYVNLDHRESIKRLLVFVYIYDQTPAFDRTHAHVTLYPSNGPRVEISLDERAPQARSCAVVTIENVKGELIVRREVKFVYGFQAELDRLYGWGLQWGRGYKSKVGER</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K0A8</accession>
    <name>A0A2M9K0A8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CG723_05665</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000002">
        <property type="protein sequence ID" value="PJN12520.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN12520">
        <property type="protein sequence ID" value="PJN12520"/>
        <property type="gene ID" value="CG723_05665"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PJN12520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="67" mass="7440" checksum="244AC0BB45EA6A1C" modified="2018-04-25" version="1">MQAAPVRATAIPTFTDALRAVESLLMSSGQRTARRNAWTSVLEDRRRAKDRVEAQRVLEEAVAARTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K0D3</accession>
    <name>A0A2M9K0D3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Amino acid transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CG723_05485</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CB01635</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000002">
        <property type="protein sequence ID" value="PJN12487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN12487">
        <property type="protein sequence ID" value="PJN12487"/>
        <property type="gene ID" value="CG723_05485"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004841">
        <property type="entry name" value="AA-permease/SLC12A_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00324">
        <property type="entry name" value="AA_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="31"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="61"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="91"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="135"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="169"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="202"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="246"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="286"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="349"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="381"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="416"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="447"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="domain" description="AA_permease" evidence="6">
        <location>
            <begin position="34"/>
            <end position="472"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PJN12487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="489" mass="50680" checksum="A23B827B603475AD" modified="2018-04-25" version="1">MPVTSPQTQNSATATAAEPTLRAGTLGTADIAFFVVSAAAPLTVMAGVAPFAIALGGIGAPVGYLLAGLTLAVFAVGFTTMSRHVRSAGAFYAYITRGLGRSVGIGAALLAMVGYNGMEIGVYGLLGTATQDTLHALFGIDIPWLPVSLAGLVLIWYGGFRSIDFGAKLLGVLLCAETGILVLLAGGVLLKGGAHGLSAASFAPGNVLVPGTAAVLAFAFAAFTGFESTVIYRREARDPGRTVRRATYIAVAFLGLFYAFIVWTVIQAFGDAHVVEAAGSDPAGLFFSAITTFVGGWAADLMHILIVTSVLASLLAFHNAINRYGLALAEEGVLPKAFGTVHAKHRSPYVAGVAQTVLGAAVVLAFWAAGADPYAQLLLWVNTPGMIGLMALQLLAAIAVPFYFRRITHEEGVLRTVVAPIAATVLLSIAIVLVCTHLDLFTGASSLVNMVLMAVAPAVFVLGVALARRLRRTKPDVYERFAAEPSTDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K0D9</accession>
    <name>A0A2M9K0D9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Esterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CG723_06020</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000002">
        <property type="protein sequence ID" value="PJN12586.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN12586">
        <property type="protein sequence ID" value="PJN12586"/>
        <property type="gene ID" value="CG723_06020"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052689">
        <property type="term" value="F:carboxylic ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012354">
        <property type="entry name" value="Esterase_lipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022742">
        <property type="entry name" value="Hydrolase_4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12146">
        <property type="entry name" value="Hydrolase_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017388">
        <property type="entry name" value="Esterase_lipase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hydrolase_4" evidence="4">
        <location>
            <begin position="19"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="1">
        <location>
            <position position="93"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="1">
        <location>
            <position position="194"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="1">
        <location>
            <position position="224"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="25"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="94"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Important for substrate specificity" evidence="3">
        <location>
            <position position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR017388-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR017388-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR017388-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF12146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PJN12586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="259" mass="28224" checksum="7B0751A4E4D41CB1" modified="2018-04-25" version="1">MPVIPGAEPYRHEGGEVGVLLCHGFTGSPQSLRPWAEYLAERGLTVSLPLLPGHGTRWEDMQVTGWQDWYAEVDRALRELRDRCSQVFVFGLSMGAALALRLAAKHGDEVAGLVLVNPGNKVHGLAAHALPVARHLVRTTKGIASDIAKEGSTEIGYDRVPLHAAHSLRNFFRIVDRELPQVTQPLVVLHSTQDHVVPPVDSARVLSRISSTDVEEILLEQSYHVATLDHDADRIFDESFAFIGRLAPSVGKEGTATGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K0M0</accession>
    <name>A0A2M9K0M0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Alpha/beta hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CG723_06570</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CB01635</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 'GDXG' lipolytic enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000002">
        <property type="protein sequence ID" value="PJN12682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN12682">
        <property type="protein sequence ID" value="PJN12682"/>
        <property type="gene ID" value="CG723_06570"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013094">
        <property type="entry name" value="AB_hydrolase_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002168">
        <property type="entry name" value="Lipase_GDXG_HIS_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033140">
        <property type="entry name" value="Lipase_GDXG_put_SER_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07859">
        <property type="entry name" value="Abhydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01173">
        <property type="entry name" value="LIPASE_GDXG_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01174">
        <property type="entry name" value="LIPASE_GDXG_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Abhydrolase_3" evidence="4">
        <location>
            <begin position="83"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF07859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PJN12682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="316" mass="33235" checksum="9151174629F34687" modified="2018-04-25" version="1">MTTHDPLTPPARTLCDAMSAAFPDPADGPLDADALRAAARAGLGKPSVPMRSVTERLVPAQDLDAPVPVRIYEPEADGPRPLVVFLHGGGWVLCDLDTHDGLCRQLAVRTGALVVSVDYRRAPEHPFPAASHDAYAVARWAAAHARELGCDPDRLFVAGDSSGGNLAAAVALRALSDPEGPKVAGQLLLYPVLDHRLGGESPVAFERGFFHTTAHMRWYWEQYLGAGGDPVAASPGLAPDLDGLPPALVLLADCDPLRDEGLAYARRLARAGVRAEVALYPGMFHGFLGAAGFLPEADAALARAAAWLTRTPGTAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K0Q1</accession>
    <name>A0A2M9K0Q1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Fatty acid--CoA ligase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_06595</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000002">
        <property type="protein sequence ID" value="PJN12686.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN12686">
        <property type="protein sequence ID" value="PJN12686"/>
        <property type="gene ID" value="CG723_06595"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-binding" evidence="1">
        <location>
            <begin position="17"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding_C" evidence="2">
        <location>
            <begin position="439"/>
            <end position="512"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN12686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="527" mass="56744" checksum="DC0310435EB82986" modified="2018-04-25" version="1">MTSTTPPRTLAQLPEYAAAAYGDREALADGEVRWTFSRLRDEIAGSSRAAVAHGIRPGTRVAIWAANSRQWILAALGAVGAGAVLVPVNTRYKAAEAADIIRRSGAEILYTERGFLGTDYVRTLTASGEDLGALHSIVVLRGEAQDDAIAWDAYLRAGEGVTETERLARAATVGPDDLSDILYTSGTTGRPKGVMTTHGQTVRLYEEWSRQVTLRTGDRYLLVNPFFHTFGYKAGVIACLLRGVTMLPEEVYDTDRVLERIATERVTCLMGPPTIFHGLIHHPRRHQTDLGALRLAGTGAATIPTELVELIRTELGAPDVFTAYGLTESGGVVSVCPTDADAWTVAHTVGRALPGTAIRIASPLGDELPAGEPGEVQVRGYHVMRGYLDDETATQEAVPQDGWLRTGDIGKLDGRGFLTITDRLKDMYVVGGFNAYPAEVENTLLGHELIVDAAVVGAPDERLGEVGVAFIVVSGPVDAKKLTAWTRERLANFKVPRRFVTVPELPRNAGGKLLKGELRRTARGGTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K0S4</accession>
    <name>A0A2M9K0S4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_06880</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000002">
        <property type="protein sequence ID" value="PJN12732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN12732">
        <property type="protein sequence ID" value="PJN12732"/>
        <property type="gene ID" value="CG723_06880"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021424">
        <property type="entry name" value="PorA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11271">
        <property type="entry name" value="PorA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014870538" evidence="2">
        <location>
            <begin position="28"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="291"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN12732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="333" mass="37505" checksum="68AE082B11D51750" modified="2018-04-25" version="1">MRRKASLILLALAVFCTAMSPLMRWYAFPRLAKIPAGQYQNAVLEAKNPTLLDYGSMQAKKVPKVTIVQTLKGNVEASEEVEKSAGRDVVVWDSLSYVVGPDGKMVSQVPERYVFDAHSQAPVHPTGKYAETVDGDKVRRDGIEFKWPFLTEKRDYEYYDAQARITRPIHYKGTQTFRGVKVYYFEQTIPWTKVPLPKTMPVKGITPESVAKTGTTRWYSTVRKFWVEPVTGAPVYGEEIQNNELRGGTLLGGRDKVTVFAGHVKMREDYIKSTVDLVKSNRVLVVLLTSYLPWGFLVLGLLLLALSLWLEARSRRPGEPEAAPEHEPEPVSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K0W4</accession>
    <name>A0A2M9K0W4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CG723_07005</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000002">
        <property type="protein sequence ID" value="PJN12754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN12754">
        <property type="protein sequence ID" value="PJN12754"/>
        <property type="gene ID" value="CG723_07005"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010296">
        <property type="entry name" value="DUF899_thioredox"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05988">
        <property type="entry name" value="DUF899"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PJN12754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="227" mass="25405" checksum="A755BADF59A9954D" modified="2018-04-25" version="1">MGLPNVVTREEWLGARQELLAREKAATRARDALNARRRELPMVEVEKLYVFEGPDGKAELLDLFEGRSQLIVYHFMFGPDQDAGCPNCSAFLDQIGHLSHLRARDTEFAAVSRAPFTRLLPFKARMGWTMPWYSSATSDFNQDFGFASGEDPRDLPGLSCFLRDGDRVYHTYSTTGRGLDGIGSINSLLDLTALGRQEEWEEPQGRASALGAPAGSARVRYHDEYLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K1B5</accession>
    <name>A0A2M9K1B5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CG723_07975</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CB01635</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000002">
        <property type="protein sequence ID" value="PJN12933.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN12933">
        <property type="protein sequence ID" value="PJN12933"/>
        <property type="gene ID" value="CG723_07975"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004747">
        <property type="entry name" value="Cyan_transport"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00896">
        <property type="entry name" value="CynX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="30"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="70"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="96"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="124"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="159"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="192"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="238"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="266"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="303"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="328"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="361"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="390"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="7">
        <location>
            <begin position="31"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PJN12933.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="427" mass="43580" checksum="22D923D5F74D5B52" modified="2018-04-25" version="1">MASEETPTMTQTPIRTESAPEAKTAPTRAWAVRLMIVGIVLAALNLRPAITSLGALLEEVRDGLGMSGSVAGLLTSVPPLCFAIFGVMAPRLARRFGPGAVVCAGMAAIAAGLVIRPFTGSTVGFLVASALALMGIAVSNVLMPVIVKRWFPDRVGSMTGLYSMALALGTSLAAAVTVPMTDALGGSWKTGLALWAALAVAAVVPWVPLARERGTEGGNAAGTPQRDDGLRITRSRTAWALAVFFGLQATAAYITMGWMAQIFRDAGVSAGTAGVLLAVTMAMGVPLAFVIPRLATRLPSQGPIVIALGVCGLAGYAGLYFAPSGGAWAWAVLLGISNCAFPLALTMVGMRARTGTGVAKLSAFAQSTGYLISIPGPLLVGVLYQHSGGWGVPIALMAALMVPQVVVGVIAGRNRTVEDEAAPAAAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K1C4</accession>
    <name>A0A2M9K1C4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Regulation of enolase 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CG723_07610</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000002">
        <property type="protein sequence ID" value="PJN12870.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN12870">
        <property type="protein sequence ID" value="PJN12870"/>
        <property type="gene ID" value="CG723_07610"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009784">
        <property type="entry name" value="DUF1349"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35332">
        <property type="entry name" value="PTHR35332"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07081">
        <property type="entry name" value="DUF1349"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="SSF49899"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PJN12870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="202" mass="21743" checksum="DC5B5392E61257FB" modified="2018-04-25" version="1">MDIELPELPFPLRTYGPDGHWSYEDGVLTGWAGPRQDRFVPPTGTALDPASDAPRLLGAPKGDFQLLARVTVGFTAAFDAGVLYLHVGEREWAKLCLERSPDEPTVCTVVTRGHSDDANAFVVGGSTVWLRISRTGSAFAFHASPDGEKWTFVRIFSLGDEESAGAALVGFMAQAPVGDGCVVTYEAIEFRPSWPQGLKDGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K1F5</accession>
    <name>A0A2M9K1F5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Asp23/Gls24 family envelope stress response protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_07795</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the asp23 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000002">
        <property type="protein sequence ID" value="PJN12900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN12900">
        <property type="protein sequence ID" value="PJN12900"/>
        <property type="gene ID" value="CG723_07795"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005531">
        <property type="entry name" value="Asp23"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34297">
        <property type="entry name" value="PTHR34297"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03780">
        <property type="entry name" value="Asp23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN12900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="153" mass="15906" checksum="583B088624CCA50C" modified="2018-04-25" version="1">MSDTVEKPGEATGGRTSVTKRGGGSAGTRGRTTIADGVVEKIAGLAARDVMGVHAMGSGLSRTFGAVRDRVPGGTKSVSRGVKAEVGEVQTALDLEIVVEYGVSIADVARDVRENVVAAVERMTGLEVVEVNIAVSDVKLPDEEDEEPESRLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K1M2</accession>
    <name>A0A2M9K1M2_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 6">L-2,4-diaminobutyric acid acetyltransferase</fullName>
            <shortName evidence="6">DABA acetyltransferase</shortName>
            <ecNumber evidence="4 6">2.3.1.178</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6 8" type="primary">ectA</name>
        <name evidence="8" type="ORF">CG723_07650</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CB01635</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the acetylation of L-2,4-diaminobutyrate (DABA) to gamma-N-acetyl-alpha,gamma-diaminobutyric acid (ADABA) with acetyl coenzyme A.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>acetyl-CoA + L-2,4-diaminobutanoate = (2S)-4-acetamido-2-aminobutanoate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16901"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:58761"/>
            <dbReference type="ChEBI" id="CHEBI:58929"/>
            <dbReference type="EC" id="2.3.1.178"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 6">Amine and polyamine biosynthesis; ectoine biosynthesis; L-ectoine from L-aspartate 4-semialdehyde: step 2/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 6">Belongs to the acetyltransferase family. EctA subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.178" evidence="4 6"/>
    <dbReference type="EMBL" id="NNBL01000002">
        <property type="protein sequence ID" value="PJN13024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN13024">
        <property type="protein sequence ID" value="PJN13024"/>
        <property type="gene ID" value="CG723_07650"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00067">
        <property type="reaction ID" value="UER00122"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033816">
        <property type="term" value="F:diaminobutyrate acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019491">
        <property type="term" value="P:ectoine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012772">
        <property type="entry name" value="Ectoine_EctA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02406">
        <property type="entry name" value="ectoine_EctA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="7">
        <location>
            <begin position="5"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000400"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00017935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU365045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PJN13024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="164" mass="17692" checksum="F8D2EE15AFD9EB3B" modified="2018-04-25" version="1">MPESLRIDRPEVADGAAIWRIARDSKVLDLNSSYSYLLWCRDFAATSVVARDSAGSVAGFITGYIRPENPHTLVVWQVAVDHAHRGRGLAGALLDGLWAKVVADGATTVLETTISPDNAASQRLFASFARRNGAEVAQTVLFDAGLFPDDGHEPEVLHRIGPIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K1M8</accession>
    <name>A0A2M9K1M8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Aspartate aminotransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CG723_07655</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CB01635</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 2">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000002">
        <property type="protein sequence ID" value="PJN13025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN13025">
        <property type="protein sequence ID" value="PJN13025"/>
        <property type="gene ID" value="CG723_07655"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044249">
        <property type="term" value="P:cellular biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000192">
        <property type="entry name" value="Aminotrans_V_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024169">
        <property type="entry name" value="SP_NH2Trfase/AEP_transaminase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00266">
        <property type="entry name" value="Aminotran_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000524">
        <property type="entry name" value="SPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="2" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotran_5" evidence="3">
        <location>
            <begin position="75"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="2">
        <location>
            <position position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000524-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PJN13025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="372" mass="38627" checksum="A9CABD8D266229CB" modified="2018-04-25" version="1">MTHPFLDLAPLSAEHFASIERRVAGLLDTSQDVVIMQGEALLPLEGAIRGTARPGTVALNIITGPYGQTFGDWLRDSGATVYDLAVPFHTAVTAEQVRDALAEHPETDFVSLVHAEAATGNTNPVAEIGEVVREHGALFYLDAVASIAAEPVLPDAWGVDLCVIGAQKAMGGPAGVSAVSVSARAWERMESNPQAPRHSYLSLLDWKHRWIDGGRKALLHAPAQLEMLALEACVERIDAEGLDALTARHAGAAAATRAGALALGGGIEPYVYEARDAAPVATTLRAPAGIDASELVARALAVDPVLPLVAGGGALAKEMIRVNHYGPQATRGVVQSSLAALGGALAEMEGSGAPVDLEGARRAVAAAWVQPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K1Y7</accession>
    <name>A0A2M9K1Y7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">DNA-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CG723_00690</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CB01635</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000001">
        <property type="protein sequence ID" value="PJN13152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN13152">
        <property type="protein sequence ID" value="PJN13152"/>
        <property type="gene ID" value="CG723_00690"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="65"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="111"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="139"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="172"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="218"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="262"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="326"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="374"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="402"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="445"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="469"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="654"/>
            <end position="682"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PJN13152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="682" mass="74191" checksum="10FF1AB230F96892" modified="2018-04-25" version="1">MSKLTDVPKRILIGRALRSDRLGETLLPKRIALPVFASDPLSSVAYAPGEVLLVLSIAGVSAYHFSPWIAVAVVVLMFTVVASYRQNVHAYPSGGGDYEVATTNLGPKAGLTVASALLVDYVLTVAVSIASGIENLGSAIPFVVEHKVLCAVLVIVLLTLMNLRGVKESGKLFAIPTYVFVAGVFIMIAWGAFRGLVLDDTMKAPTADFHIKAEHQGLAGFALVFLLLRAFSSGCAALTGVEAISNGVPAFRKPKSKNAATTLAAMGLLAVTMFCGIIALAMSTKVRMAENPATDLIHNGVAVGGSYVQNPVISQVAEAVFGKGSFLFIILAAATALVLFLAANTAYNGFPLLGSILAQDRYLPRQLHTRGDRLAFSNGIVLLAGAAALLVVIYGADSTRLIQLYIVGVFVSFTLSQTGMVRHWNRHLRTEKDPAKRRHMVRSRAINTFGAFFTGLVLVVVLVTKFTHGAWVALLGMCIFYATMTAIRKHYDRVAEEIQAPETPTDDSVRPSRVHSIVLVSKIHRPTLRALAYAKLMRSDTLEALSVNVDPAETKALREEWERRGIDVPLKVLDSPYREITRPIIEYVKSLRRDSPRDAVSVIIPEYVVGHWYEHLLHNQSALRLKGRLLFTPGIMVTSVPYQLESSEVAKKRARRRSEWNAPGAVRRGPVEKRPKEPSNKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K1Z5</accession>
    <name>A0A2M9K1Z5_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Trk system potassium uptake protein TrkA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CG723_00670</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000001">
        <property type="protein sequence ID" value="PJN13149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN13149">
        <property type="protein sequence ID" value="PJN13149"/>
        <property type="gene ID" value="CG723_00670"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015079">
        <property type="term" value="F:potassium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006036">
        <property type="entry name" value="K_uptake_TrkA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006037">
        <property type="entry name" value="RCK_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036721">
        <property type="entry name" value="RCK_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003148">
        <property type="entry name" value="RCK_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02080">
        <property type="entry name" value="TrkA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02254">
        <property type="entry name" value="TrkA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00335">
        <property type="entry name" value="KUPTAKETRKA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF116726">
        <property type="entry name" value="SSF116726"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51202">
        <property type="entry name" value="RCK_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51201">
        <property type="entry name" value="RCK_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0406">Ion transport</keyword>
    <keyword evidence="4" id="KW-0520">NAD</keyword>
    <keyword evidence="3" id="KW-0630">Potassium</keyword>
    <keyword evidence="2" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="RCK N-terminal" evidence="5">
        <location>
            <begin position="2"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="domain" description="RCK C-terminal" evidence="6">
        <location>
            <begin position="133"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00017378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PJN13149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="223" mass="24069" checksum="966B70A4FB1900D2" modified="2018-04-25" version="1">MHIVIMGCGRVGSALAQTLEQQGHTVAVIDQDPTAFRRLGSGFGGRRVTGVGFDQDTLREAGIEEAGAFAAVSSGDNSNIIAARVAREMFGIENVAARIYDPRRAEVYQRLGIPTVATVRWTADQMLRRLLPSGAEPLWRDPTGGVQLAEVHASVAWVGHKISRLQEETGVRVAFVTRLGEAILPTSQTVLQEGDLVHVMMRTDDVEKVEAAFAEGPEEEGGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K2H3</accession>
    <name>A0A2M9K2H3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_01745</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000001">
        <property type="protein sequence ID" value="PJN13329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN13329">
        <property type="protein sequence ID" value="PJN13329"/>
        <property type="gene ID" value="CG723_01745"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014961468" evidence="1">
        <location>
            <begin position="35"/>
            <end position="549"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN13329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="549" mass="59982" checksum="E69F9C9EDE2039C4" modified="2018-04-25" version="1">MSRDFNRRGFLGAATVAGLTVAGAGSLTACGSGAASGGGGAKASAKLKLPTYVPANVAAPDLPGNAAGLDPAYLRYPKNLTRSVTKKPGDGKPVTALTETFTTAAPAMNRNQYWQELNKRLGSELKMTIVNGLGADDVYRAKFNATIAGGDMPDLMWFPPNQGLKNVPALLEAKFHDLTEYLSGDAVKKYPNLANIPEFAWKTAVFNGKIWGMAVPYGRMGQVYVANEDFWKPVGGVQFDSAQDFFDKAKELLDVKRKKYVLEPAYVNHILQFAYWHGAPNGWRNEGGKLTHYFETDEFHAGLEFALKCQKAQLFWPDPNLPTTLEKMEGGFLGLHVQSFPGFLSDSNQYDWPEKVVVPFAAEKGLTPTWGYGYGSVGFTAINKAVSKDRIDTLLQVMNYLSAPFGTEERLFLDNGIEGTHHTRSKDGDVLLNKKGNAEVITTRQAINFFGNAPETLYLPGKPDITRGIHGAQVELMKLAQVNPQTGFFSDTYANKGASSTDTVYQAVKDIVAGRTPLSSFKKDILPTWQREAGNAMRDEFEKAIADAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K2R1</accession>
    <name>A0A2M9K2R1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CG723_02285</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000001">
        <property type="protein sequence ID" value="PJN13424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN13424">
        <property type="protein sequence ID" value="PJN13424"/>
        <property type="gene ID" value="CG723_02285"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045999">
        <property type="entry name" value="DUF5955"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19380">
        <property type="entry name" value="DUF5955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PJN13424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="104" mass="10945" checksum="CB4895518EEE6377" modified="2018-04-25" version="1">MLRSVGQKLVAVSEEDPRVTELRTAVSRLRRELAAHPAEFPDRAVAEDELAALDAMAAGGLPEIPRLRRSLLLIAGAIGSVSALAKGLGDVRSAVELFGGPPLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K391</accession>
    <name>A0A2M9K391_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">CoA ester lyase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CG723_03275</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CB01635</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000001">
        <property type="protein sequence ID" value="PJN13594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN13594">
        <property type="protein sequence ID" value="PJN13594"/>
        <property type="gene ID" value="CG723_03275"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005000">
        <property type="entry name" value="Aldolase/citrate-lyase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011206">
        <property type="entry name" value="Citrate_lyase_beta/mcl1/mcl2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_Kinase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040442">
        <property type="entry name" value="Pyrv_Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03328">
        <property type="entry name" value="HpcH_HpaI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015582">
        <property type="entry name" value="Cit_lyase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="SSF51621"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HpcH_HpaI" evidence="6">
        <location>
            <begin position="35"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="92"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3 4">
        <location>
            <position position="140"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="166"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR015582-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR015582-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF03328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PJN13594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="297" mass="30784" checksum="DA5366294BA852BE" modified="2018-04-25" version="1">MSAEHNTVEPASADPARPELADPERLGRARLAAARTLLFVPGHRPDRFEKAAAAGADAVIVDLEDAVAPDGKDAARRHAADWLARGGDAVVRINAPGTAWWDADLDLVTAFGCPVMLPKAEDPEVIARIAEVCAVIPLVETAAGIERALDVCCAPGVVRAAFGSVDLATELGVRHDDTLALAYGRSRLVMACAAAGVAPPLDGVTTALDDADALAQDLQHARRLGFGGKLCIHPKQLPAVTAGFAPTDEELAWARKVLAAGDAVSAVDGVMVDRPVQERARRLLGVALTTGSAGEVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K3M0</accession>
    <name>A0A2M9K3M0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transketolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_04000</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000001">
        <property type="protein sequence ID" value="PJN13709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN13709">
        <property type="protein sequence ID" value="PJN13709"/>
        <property type="gene ID" value="CG723_04000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005474">
        <property type="entry name" value="Transketolase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00456">
        <property type="entry name" value="Transketolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TRANSKETOLASE_1" evidence="1">
        <location>
            <begin position="31"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN13709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="237" mass="24790" checksum="867513C0BA8254D0" modified="2018-04-25" version="1">MTTTAARTAAGSHAYEDLPALMGRMTGDEKHGPAATSTLDVLWVLYDRVLRVTPEGVRDPERDRFLLSKGHGPMAYYAVLAAKGFVPKEWLPGFGSYDSPLGHHPDRVLVPGVEIASGSLGHGLPIAVGTALGLRAQGLAGPAVWTLIGDAELDEGSNHEAIAFAGPAALDRLHAVVVDNSSASHARPGGIAARFEAAGWSAATVDGRDHEALYEAFTAPHPGEPRVVVARVEPKSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-09-29" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JEJ2</accession>
    <name>A0A2M9JEJ2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_45480</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000055">
        <property type="protein sequence ID" value="PJN05315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN05315">
        <property type="protein sequence ID" value="PJN05315"/>
        <property type="gene ID" value="CG723_45480"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="847"/>
            <end position="880"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1104"/>
            <end position="1148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="1129"/>
            <end position="1146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN05315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="1268" mass="134561" checksum="1E8BC9BC29C68D48" modified="2018-04-25" version="1">MTDASLSGDRWVAAERIIDSVVVTGDGNIVIYYADGGHAEPVAPASLADAERLLFGPVPTAPTSRPWTWLTPEAGLHPLVRRPEESNLVEWARDGRGTALRLVCAPSGQGKTTLALQVCARLRDLGWTAGVLDLERAPAPYAANAAAMAGSLARSARHWDRQLAAVAALPRLSGRALLVVDSAEVHRSRIEELLRTVTELPTAQGVPPVKLLLLARDTGEWWEELSIGSHRHHWIERRVTRLAPVMEGMGTAGLGEMWRDATAGFTRAAEQAGMSLAPGSADLIAEGCPTVVPTTLHLYAAALLRILDAVEGRATSLEYRDHPITGLVEHEQRYMTGAFTAAGVPISHDRARLLLALVCLYAPPDEPAALRTLGRVETTVAQGDLARMARQLQALYPGGGRSLWRAPGPDRLADSVLYALAAGSRSDVEAEGLFRTLCGTDDWFEGRDCARVLIRALGTAEEEPTVSPTVSQRVGGAVSALILDHPRGYVPAALEMAADRFEQQIRAAVAGRGATAPASRLGVGELEALDVLLGSTAGSDSRAQIAVAISDRLVHAVPEAWQGTGPWHASEQVTRLVRYARALRRTDDLQRASSVASEAVTLVRRMLESGDAAANGRIAQRLSRASSELAEAGMDDAALELSTAAVKSAWSSLSSPEPLDIAERAAILNSHSQRLYVLRQAHAAVECSAESLSLYREAMQQSPGRNELELAGAHADYGMKLRAARRPQQAEPHLADALAAYRRHLAADDRPGTRHGLVQILSAYAAVLHDLGRTRQAILHAEEAVELQRGLAAHDPDATVDLAATLNLLGATLAETGSKEAGCRHLEDAVSLLRGMRGKPRVTEELASALANLGTLYSECGDPARAVSLLEEALVLKETRGARLNGAVDDLKATAHNLSLALRQVGDDARAQTVRARFVDSRGEGLSLPAVRTAAEVKAEIPPVTEELRAAARRIPGGSLYAIDPGFDPQGEVPGHGIRGAFRVGADGEITGYEANERYRPSPTALNYPAPTDPVDEAAQLALTGYGSDSALERALKSATVAVAKAAPAATGALEASVFTSASHIPDGIAATRISGEELLALLPAEAVIHINPASPVAYRLDRAGQGTEEAGEKVRSRENTSATPATVPSETPPQPPPPSAFRAAAPPAPALPEDEIAQLCARYTDGEPVLGLLTAALRRSRVWYITAGGNPHRPSIGKMYDGRLAVFVYSSREYASTEVLNFDGGARLSESMMSDLLKKLPPSTYVVINNEGPHALQIPASALLAYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JES8</accession>
    <name>A0A2M9JES8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">NrdH-redoxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CG723_45100</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000050">
        <property type="protein sequence ID" value="PJN05388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN05388">
        <property type="protein sequence ID" value="PJN05388"/>
        <property type="gene ID" value="CG723_45100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008554">
        <property type="entry name" value="Glutaredoxin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05768">
        <property type="entry name" value="Glrx-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PJN05388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="95" mass="10986" checksum="8D3D0E3211FC669B" modified="2018-04-25" version="1">MAGMSPIFRRSEKKNPEERLVTLVGKPGCHLCDDAQEVIEKVCGELGASWEKKDINQDEELYRLYWEQIPVVLVDGAQHDFWKVNEDRLRRALTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JF06</accession>
    <name>A0A2M9JF06_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">DoxX family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CG723_44360</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CB01635</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000047">
        <property type="protein sequence ID" value="PJN05481.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN05481">
        <property type="protein sequence ID" value="PJN05481"/>
        <property type="gene ID" value="CG723_44360"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032808">
        <property type="entry name" value="DoxX"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07681">
        <property type="entry name" value="DoxX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="7"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="60"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="105"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="136"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PJN05481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="166" mass="16797" checksum="9F429CF0797C4A40" modified="2018-04-25" version="1">MHGADLGLLIMRAVLGVMLFVHGANKVFGPGGVAGTARWFESVGLRPGWLHARLAAACEIGAGLLMAAGLAFPAAGAAFAGLMLVAGLTDHRGKGFFVFKGGWEYVGLVGLMAISLVAVGPGAWSLDEVLGWHLTGVGWAGSAAVVGAAAALVLLAARRTPAQDRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JF57</accession>
    <name>A0A2M9JF57_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Peptidase C14</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CG723_44710</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000048">
        <property type="protein sequence ID" value="PJN05452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN05452">
        <property type="protein sequence ID" value="PJN05452"/>
        <property type="gene ID" value="CG723_44710"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029030">
        <property type="entry name" value="Caspase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52129">
        <property type="entry name" value="SSF52129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PJN05452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="377" mass="41029" checksum="21AA91767A0A7B2A" modified="2018-04-25" version="1">MRALPDPAASRAVLVGVSRYTALEPLPAVANNLPALAQALTGPTSWNLPARHCTVVAEPETSRDMLDPVKEAAEATSDTLLVYFAGHGLLDGRGELFFGLPRSVQGHSYTGVTYQALREIITDCAARRFVIILDCCMSGRALGTMGGEDLLADQAEIDGSYLLAAAPENGRALAPPGEIHTAFTGELLNALQHGIPGRTRELDLNTVYHHLRGELAAKGRPTPQKRDRNTAGRLVLAVNQAYRPATAPTHPAETDWPDPDDCHTPIAFLEALAEMRAHTGLTIRAISRRTDPPLAPDTVSRLLNATTLPATWKTTSRYLAACGLTPDQLSIWHRAWQRLHAQEQELARPKSPAPTAGPQRTRLWWDRLAKRGDSGRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JFI3</accession>
    <name>A0A2M9JFI3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">FAD-binding molybdopterin dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_43955</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000045">
        <property type="protein sequence ID" value="PJN05563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN05563">
        <property type="protein sequence ID" value="PJN05563"/>
        <property type="gene ID" value="CG723_43955"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.43.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005107">
        <property type="entry name" value="CO_DH_flav_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036683">
        <property type="entry name" value="CO_DH_flav_C_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016167">
        <property type="entry name" value="FAD-bd_PCMH_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002346">
        <property type="entry name" value="Mopterin_DH_FAD-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03450">
        <property type="entry name" value="CO_deh_flav_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00941">
        <property type="entry name" value="FAD_binding_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01092">
        <property type="entry name" value="CO_deh_flav_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55447">
        <property type="entry name" value="SSF55447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="SSF56176"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="1">
        <location>
            <begin position="1"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN05563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="325" mass="34735" checksum="8E9F665E2C5C287E" modified="2018-04-25" version="1">MRPFTYVRAETIARALEKAQTRGTMFLAGGTELLNWARIGIENPAHVVDICHLASLDGIEASGNGVRIGALGRLNDVAQDPRVVSSYPVLSQAILKAASAQIRNVATIGGNPVQRTRCPYFRSAEPVPCNKRVPGSGCAALQGANERLAIFGWTEECVATQPSDPAVALACLDAQIVTEHPDGGRTIPATQFHMLPAEDSSAHNVLRTGELITAVDLGAPAPKSAYVKVRERQSYEFALVSAAAAVEVEEGVFSRVRLALGSVAMRPWRLYESERALVGLRPGSPEVLDAVTAGFRDSRPLSSNAYKIPLARNTAMRALELALEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-09-29" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JFK0</accession>
    <name>A0A2M9JFK0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_43440</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000043">
        <property type="protein sequence ID" value="PJN05668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN05668">
        <property type="protein sequence ID" value="PJN05668"/>
        <property type="gene ID" value="CG723_43440"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033186">
        <property type="entry name" value="HerA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05872">
        <property type="entry name" value="DUF853"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF853" evidence="2">
        <location>
            <begin position="91"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="516"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN05668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="581" mass="60879" checksum="0530E7C051DD1551" modified="2018-04-25" version="1">MSDSEPIPAGPANAKPSSGVGAGAGLTPGTAASSAPGGTGEASPTGTTGPEPVTTAPALPAPALEIAAGYAFAGPALDLGALVWDGRCLPDAQIRIPLGMLNRHGLVAGATGTGKTKTLQLVAEQLAAQGVPVFLADIKGDVSGISAPGEPGHRVSQRSAEVGQEWRATGFPSEFYALGGIGSGIPLRATITGFGPVLLSKCLQLNQTQEQSLGLIFHYADQKGLELVDLKDLRAVVTFLTSDEGKQELKTIGGLSTTTAGVILRALTAFEQQGMGDFFGEPEFDSSELLRTAPDGRGLVSVLELPAVQDKPHLFSTFLMWLLADLFQDLPEVGDVEKPKLVFFFDEAHLLFSGASKAFLEAITQTVRLIRSKGVGVFFVTQTPKDVPSDVLAQLGNRVQHALRAFTPDDQKALKSTARTFPHSAYDLEELLTSLGTGEAVVTVLSEKGAPTPVAATRLRAPESLMGPIDAAALDKAVKESVLYSRYANAVDRESAYEKLTAQEAETQARKDVEAQAAEAEKAEKAEKAVARGSGGRGKPKEDASVVEQVVGSGIFKSLARSVGTQLGREISRSLFGTRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JFW3</accession>
    <name>A0A2M9JFW3_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 6">Alanine dehydrogenase</fullName>
            <ecNumber evidence="3 6">1.4.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">ald</name>
        <name evidence="13" type="ORF">CG723_42890</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">CB01635</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the reversible reductive amination of pyruvate to L-alanine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>H2O + L-alanine + NAD(+) = H(+) + NADH + NH4(+) + pyruvate</text>
            <dbReference type="Rhea" id="RHEA:18405"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:57972"/>
            <dbReference type="EC" id="1.4.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="10">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 6">Amino-acid degradation; L-alanine degradation via dehydrogenase pathway; NH(3) and pyruvate from L-alanine: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the AlaDH/PNT family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.4.1.1" evidence="3 6"/>
    <dbReference type="EMBL" id="NNBL01000041">
        <property type="protein sequence ID" value="PJN05780.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN05780">
        <property type="protein sequence ID" value="PJN05780"/>
        <property type="gene ID" value="CG723_42890"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00527">
        <property type="reaction ID" value="UER00585"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000286">
        <property type="term" value="F:alanine dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042853">
        <property type="term" value="P:L-alanine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd05305">
        <property type="entry name" value="L-AlaDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008141">
        <property type="entry name" value="Ala_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008142">
        <property type="entry name" value="AlaDH/PNT_CS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007886">
        <property type="entry name" value="AlaDH/PNT_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007698">
        <property type="entry name" value="AlaDH/PNT_NAD(H)-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42795">
        <property type="entry name" value="PTHR42795"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01262">
        <property type="entry name" value="AlaDh_PNT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05222">
        <property type="entry name" value="AlaDh_PNT_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000183">
        <property type="entry name" value="Alanine_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01002">
        <property type="entry name" value="AlaDh_PNT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01003">
        <property type="entry name" value="AlaDh_PNT_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00518">
        <property type="entry name" value="alaDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00836">
        <property type="entry name" value="ALADH_PNT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 6 9" id="KW-0520">NAD</keyword>
    <keyword evidence="9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AlaDh_PNT_N" evidence="12">
        <location>
            <begin position="4"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="domain" description="AlaDh_PNT_C" evidence="11">
        <location>
            <begin position="149"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="7">
        <location>
            <position position="96"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="7">
        <location>
            <position position="270"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="15"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="75"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="134"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="198"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="203"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="220"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="239"/>
            <end position="240"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="267"/>
            <end position="270"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="298"/>
            <end position="301"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="323"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005689"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR000183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000183-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000183-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000183-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000183-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM01002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM01003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PJN05780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="371" mass="39547" checksum="B13ABC9BB79952E4" modified="2018-04-25" version="1">MKVGIPREVKNNEFRVAITPAGVHELVRNGHQVFVEQNAGVGSSITDDEYVSAGAQILGTADEVWATADLLLKVKEPIAEEYHRLRKDQTLFTYLHLAASRECTDALLESGTTAIAYETVETPNRALPLLAPMSEVAGRLAPQVGAYHLMAANGGRGVLPGGVPGVLAARAVVIGGGVSGWNAAQIAIGMGFHVTLLDRDINKLKEADKIFGTKIQTVVSNAFELEKACLEADLVIGAVLIPGAKAPKLVTNELVSRMKPGSVLVDIAIDQGGCFEDSHPTTHAEPTFPVHNSVFYCVANMPGAVPNTSTYALTNATLPYIVELANRGWVEALRRDPALALGLNTHDGKVVYREVAESHGLEYTELESLLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JGA9</accession>
    <name>A0A2M9JGA9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CG723_42030</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000038">
        <property type="protein sequence ID" value="PJN05914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN05914">
        <property type="protein sequence ID" value="PJN05914"/>
        <property type="gene ID" value="CG723_42030"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PJN05914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="144" mass="16157" checksum="2D6167F5A310AC76" modified="2018-04-25" version="1">MHESFADAKMRSSQWKSYGFRIAPDVLARLKERLSADRMSSGNRQLAIGHYLDAALRHVSGDVPQWIDRATDFATERLWDSESTQPSSYRVGSVAHAWVSGLSNALQSADFGRKGTLVISAQVELYLDALESEGPLVRPERRRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JGT0</accession>
    <name>A0A2M9JGT0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CG723_41570</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CB01635</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">In the C-terminal section; belongs to the transposase 35 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000036">
        <property type="protein sequence ID" value="PJN06090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN06090">
        <property type="protein sequence ID" value="PJN06090"/>
        <property type="gene ID" value="CG723_41570"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032196">
        <property type="term" value="P:transposition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001959">
        <property type="entry name" value="Transposase_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010095">
        <property type="entry name" value="Transposase_IS605_OrfB_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01385">
        <property type="entry name" value="OrfB_IS605"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07282">
        <property type="entry name" value="OrfB_Zn_ribbon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0815">Transposition</keyword>
    <feature type="domain" description="OrfB_IS605" evidence="6">
        <location>
            <begin position="160"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="domain" description="OrfB_Zn_ribbon" evidence="7">
        <location>
            <begin position="314"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="179"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="187"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF07282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PJN06090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="413" mass="46678" checksum="E038A4CFBF6EE2AC" modified="2018-04-25" version="1">MDDQAHAARAMWNQLHDLWQMTPKCQRALTRMDQALRQARKEIDWYAVLPAQAAQAVLKTYFQAWRNCWDGRADEPNFKARFRTALSVDIPQGRDLQIKRVHRRWGMVNIPKVGRVRFRWTKDLPVGKLANKENRITGARLVKDGLGWHIAFRIQTLELKPEPHQGPEVGIDAGVNLPLALSDGNHQDHGRPPRLPDGTADRDKWLNPDEKAKLLRLEQRAAHRKSFRKPKERSSNRLHATYDQIKQLRARATRRAIDWQHKTTTAIVKQYGTVVVEQLQITNMVKSAKGTIENPGRNVAQKSGLNRSISQEAWGRTVTLLTYKTARNGGILVKVPAPNTSLRCSACGFITPGSREDQATFVCKNPDCGWSANADWNAARNVLHLYRIGLVAIPAAGRAVVRRTRGVKPAAAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JGX1</accession>
    <name>A0A2M9JGX1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">IS110 family transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_40805</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000035">
        <property type="protein sequence ID" value="PJN06092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN06092">
        <property type="protein sequence ID" value="PJN06092"/>
        <property type="gene ID" value="CG723_40805"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003346">
        <property type="entry name" value="Transposase_20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002525">
        <property type="entry name" value="Transposase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01548">
        <property type="entry name" value="DEDD_Tnp_IS110"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02371">
        <property type="entry name" value="Transposase_20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DEDD_Tnp_IS110" evidence="1">
        <location>
            <begin position="11"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN06092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="401" mass="43219" checksum="208FD66A80527E0F" modified="2018-04-25" version="1">MIDTGDIDVFLGLDVGKGEHHATAITPAGKKAFDKRLPNTEPKLRELFAKLQAKHGTVLVVVDQPASIGALPLAVARDMGCPVAYLPGLTMRRIADLYPGEAKTDARDAFIIADAARAMPHTLRAIDGEDETIAELEMIVGFDDDLAGEATRVANRLHGLLTQIHPSLERVLGPRLQHPAVLALLERFGSPAQIRKAGRRRLVTLLRPKAPRMAERLVEEIFTALDEQTVTVPGTEAAALIVPSLATSLTAVLDQRKLLAGRIEELLEAHPLSKVLTSMPGIGVRTGARILIEVGDGSTFPTAGHLAAYAGLAPATRSSGSSIRGEQPSRRGNKQLKRAFFLSAFAALADPASRTYYDRKIAQGKHHTQALLCLARRRADVLFAMLRDGTFYEPQPSASVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JGZ8</accession>
    <name>A0A2M9JGZ8_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HTH araC/xylS-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_40480</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000034">
        <property type="protein sequence ID" value="PJN06156.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN06156">
        <property type="protein sequence ID" value="PJN06156"/>
        <property type="gene ID" value="CG723_40480"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="1">
        <location>
            <begin position="82"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN06156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="181" mass="20150" checksum="303F996CC9A7F2E1" modified="2018-04-25" version="1">MPARARAVDDCAPDLLLPRLVHLDDLPELRRHLDGLARIRRRPGPDASARSTAALVALLLEIHAQAARAAGDLPALMDRRVHDVVEWLARHPTRRLDLHAAAASAELSADQFSRLFRRETGQSFRAYQVTVRIDRARELLAESGMTVSQVAKALGYADHRLFVRQFKARTGTAPGIWKRSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JH00</accession>
    <name>A0A2M9JH00_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CG723_40500</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000034">
        <property type="protein sequence ID" value="PJN06159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN06159">
        <property type="protein sequence ID" value="PJN06159"/>
        <property type="gene ID" value="CG723_40500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03255">
        <property type="entry name" value="ABC_MJ0796_LolCDE_FtsE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017911">
        <property type="entry name" value="MacB_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="1"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="33"/>
            <end position="40"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PJN06159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="241" mass="25711" checksum="B096F71275232BFF" modified="2018-04-25" version="1">MDFRIPGRRRETTRVLHDIDLDVPEARLTAIVGPSGSGKSTLLLCTAGLERATAGSIEILGTDVLSLTPRKQAAFRSENIGFIFQEYNLVSSLTVEDNIALPARLAGHRVPKSRVSDAMSRLGIAQHARRRPDRLSGGERQRVAVARVVANQPRVVFADEPTGALDLKSGHVVLDWLQALPAQGTTVLMVTHDPHAAARADQVVVMGSGRVHAIIPGGDSHAVSDAVLSAQSEDEAAEEAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JH64</accession>
    <name>A0A2M9JH64_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Anti-sigma factor antagonist</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CG723_40070</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CB01635</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the anti-sigma-factor antagonist family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000033">
        <property type="protein sequence ID" value="PJN06220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN06220">
        <property type="protein sequence ID" value="PJN06220"/>
        <property type="gene ID" value="CG723_40070"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043856">
        <property type="term" value="F:anti-sigma factor antagonist activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.750.24">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003658">
        <property type="entry name" value="Anti-sigma_ant"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002645">
        <property type="entry name" value="STAS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036513">
        <property type="entry name" value="STAS_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13466">
        <property type="entry name" value="STAS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52091">
        <property type="entry name" value="SSF52091"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00377">
        <property type="entry name" value="ant_ant_sig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50801">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="STAS" evidence="3">
        <location>
            <begin position="16"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PJN06220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="125" mass="13480" checksum="2B691D87C64D3503" modified="2018-04-25" version="1">MRQGEQRRGATDAPPAPPVVYETGDCVVVALRGEVDIVTLQDSVALLETVAAGPAATVVIDLTRTTFFDCSGLTLLLRTRRRVESRGGRLRVVCNQPRTLRLLEVTGLLPLFAPAPTVEAAVRQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JH86</accession>
    <name>A0A2M9JH86_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">N-acyl-D-amino-acid deacylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_40210</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000033">
        <property type="protein sequence ID" value="PJN06244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN06244">
        <property type="protein sequence ID" value="PJN06244"/>
        <property type="gene ID" value="CG723_40210"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013108">
        <property type="entry name" value="Amidohydro_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07969">
        <property type="entry name" value="Amidohydro_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="SSF51338"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydro_3" evidence="1">
        <location>
            <begin position="66"/>
            <end position="405"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN06244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="416" mass="44028" checksum="96B8AC1795400A48" modified="2018-04-25" version="1">MPQLILRQARVEDARSPCDVVIDGGRVRAVGDASGQDADEVIDCAGRVVLPGFVEPHLHLDKALLDGVRSSPDGTLAGAIAVTGELKSAFTHEDVLARARRVLEAAVLNGTTAIRAHPDVDPIAGLLGVEVLLQLREEYADVVDLQIVAFPQEGVLRAPGTEKLLIAALAAGADVVGGCTYNEATLDDCHRHVELVLDLAAQHGIPADLHADFADDASDPRYALAEFIAGETVRRGLGGRVTLGHMTSLGGREPADRARAMAALAGAGVAVVPLPATDLHLGGRRDTRSVRRGIAPVRELWDHGVLAACSSNNIRNAFTPFGRADPLDTALLLAQTGHLSGPVDLHRVLRMVTHDAARVIGVADDYGVRPGARADLVVLDTQVYDDIVLDRPERAHVVKAGKVVARTTRTSELLLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JH92</accession>
    <name>A0A2M9JH92_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CG723_41025</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000035">
        <property type="protein sequence ID" value="PJN06127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN06127">
        <property type="protein sequence ID" value="PJN06127"/>
        <property type="gene ID" value="CG723_41025"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PJN06127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="293" mass="33387" checksum="A35A5EDB6A217C27" modified="2018-04-25" version="1">MTDGDRPVDPNDDPATAAKRLTIDSKVLRELYLLSGNECAWPGCTVPLAPDEGGMLGEIAHIRAAESGGARFDPGMTNNERRAFTNLVLLCPTHHTLIDHVGSRHRFDWACLEDVKHRHESRFRRALDCLERTEEQYIDQTRATTVVHCTTLRRMYGDLLGEEDRKGTAESVNQIADQLRRAVPAARQLLSMLVEENQEISVAEAADRGGLTQERIRELVRQLDRLWFAALLPEEYDDPDILPERITLRDSVWDHNPVFDGYAFWDDLRRHVAEREDLTFADMIVGLNFSLLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JHD7</accession>
    <name>A0A2M9JHD7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Pyruvate dehydrogenase (Acetyl-transferring) E1 component subunit alpha</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CG723_39840</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CB01635</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000032">
        <property type="protein sequence ID" value="PJN06298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN06298">
        <property type="protein sequence ID" value="PJN06298"/>
        <property type="gene ID" value="CG723_39840"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016624">
        <property type="term" value="F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001017">
        <property type="entry name" value="DH_E1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017596">
        <property type="entry name" value="PdhA/BkdA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11516:SF41">
        <property type="entry name" value="PTHR11516:SF41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00676">
        <property type="entry name" value="E1_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="E1_dh" evidence="3">
        <location>
            <begin position="24"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PJN06298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="352" mass="37686" checksum="058D3060517FB703" modified="2018-04-25" version="1">MTVLDAPAPSAPGTAAALTGLQLYRAMVVGRAFDRTATTFTRQGRLAVYPSSRGQEACQTASVLALRPTDWIFPTYRESVALLTRGIPAEDVLTLFRGDRHCGYDPAAHRAAPQCTPLATQCLHAAGLADAARMRGDDVVALAYIGDGATSEGDFHEAVNYAAVRRAPVVFFIQNNQYAISVPLSKQTAARSLADKAEGYGATGAVVDGNDALAVHAVVAEAAHRARTGGGPTLVEALTYRMEAHTNADDDTRYRSADEVAAWADKDPVARLEHTLVDDGVLDRAGIAETARAAEELSAALRRDFAEPPRRDPMEMFQHVYHHPPHHLREQSALLADERAADTGPAAEGARR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JHX1</accession>
    <name>A0A2M9JHX1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_38755</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000029">
        <property type="protein sequence ID" value="PJN06486.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN06486">
        <property type="protein sequence ID" value="PJN06486"/>
        <property type="gene ID" value="CG723_38755"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014637720" evidence="2">
        <location>
            <begin position="22"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="26"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN06486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="53" mass="5695" checksum="2C0FD1635789F58E" modified="2018-04-25" version="1">MLFLVAALLLLGVALGSVAHAPLPVTLVAAAVIGIWLVVFAVRERTARRRHQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JI62</accession>
    <name>A0A2M9JI62_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_38410</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000028">
        <property type="protein sequence ID" value="PJN06575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN06575">
        <property type="protein sequence ID" value="PJN06575"/>
        <property type="gene ID" value="CG723_38410"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015128">
        <property type="term" value="F:gluconate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003474">
        <property type="entry name" value="Glcn_transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30354">
        <property type="entry name" value="PTHR30354"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02447">
        <property type="entry name" value="GntP_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002746">
        <property type="entry name" value="Gluconate_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00791">
        <property type="entry name" value="gntP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="54"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="137"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="174"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="212"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="273"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="310"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="350"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="388"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="430"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="468"/>
            <end position="492"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN06575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="493" mass="50784" checksum="FFBF6CF774E0B3F4" modified="2018-04-25" version="1">MPLIPLAATAPAPAPPHTGGLLTIIGGTAGLLTCAALGIILLLFLIIKVRLQPFLALLTVSIAVGLAAGLSVTELFGTVQKSDAVSLIESGMGGTLGHVAIIIGLGTMLGAVLEVSGGAEVLASRLLNLFGEKRAPLAMGLTGLIFGIPVFFDVGIFVLAPIVYAAAKRGGKSIVLYAMPLLAGLSMTHAFLPPHPGPVAAAGLLHVQLGWVILMGIICGIPAVLAAWAWSAWIGKRIFVPVPQDMVEAADEAKAALVEEQRKAGVKPTEKPVPLGTVLAIIGTPLVLILLATFSSIALDPSTVRSVIEFFGHPFVALTIALLLAYYLLGIRRGWSRKSLETVSTASLKPVANILLVVGAGGIFGAVLKGSGVAQALSDTFNDVGLPVIVLAYLISLVLRVAQGSATVAIVTTAGIVLPLIEAGHYSQPFTALVIMAISAGSIFASHVNDGGFWMVAKYFGISERDTLKTWTVLESVLSVAGFAVAAVISLFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JI85</accession>
    <name>A0A2M9JI85_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Peptide ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CG723_38585</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000028">
        <property type="protein sequence ID" value="PJN06606.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN06606">
        <property type="protein sequence ID" value="PJN06606"/>
        <property type="gene ID" value="CG723_38585"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03255">
        <property type="entry name" value="ABC_MJ0796_LolCDE_FtsE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017911">
        <property type="entry name" value="MacB_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="2"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="38"/>
            <end position="45"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PJN06606.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="228" mass="24668" checksum="FEA4CAC8920609D2" modified="2018-04-25" version="1">MYQLRGVTKQYRRGKDTVDALAGVDLTIGDGDRLVIQGPTGGGKSTLLQMLGGLDRPTAGSIELDGVDLAKLPEARLTKFRAESIGFVFQSFNLIPTLNAQENVETALVPLGLKAADRRERAAQALNSVGLGERLGHLPGEMSGGQQQRVAIARALVKNPKVLLADEPTGNLDESMRDEIMDVLETMWKEHGLTFIMVTHDSSIARRAPRLATIRKGRITITENSKAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JIJ9</accession>
    <name>A0A2M9JIJ9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">TetR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CG723_38020</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000027">
        <property type="protein sequence ID" value="PJN06716.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN06716">
        <property type="protein sequence ID" value="PJN06716"/>
        <property type="gene ID" value="CG723_38020"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023772">
        <property type="entry name" value="DNA-bd_HTH_TetR-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041490">
        <property type="entry name" value="KstR2_TetR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17932">
        <property type="entry name" value="TetR_C_24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01081">
        <property type="entry name" value="HTH_TETR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="5">
        <location>
            <begin position="10"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="4">
        <location>
            <begin position="33"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PJN06716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="197" mass="22112" checksum="93446BFC0B288ABB" modified="2018-04-25" version="1">MPRTSDGDGTPVPQRLLAAATRLFAERGFDRTSVQEIVEAAGVTKGALYHYFGSKDDLLHEVYARVLRLQQERLDAFADADAPVEQRLRDAAADVVVTTIENLDDASIFFRSMHQLGPEKHKQVRAERRRYHERFRALIEEGQQAGVFSTATPADLVVDYHFGSVHHLSTWYRPGGPLAPQEVADHLADLLLRALRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-05-25" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JJ60</accession>
    <name>A0A2M9JJ60_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Cation transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CG723_37160</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CB01635</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000025">
        <property type="protein sequence ID" value="PJN06908.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN06908">
        <property type="protein sequence ID" value="PJN06908"/>
        <property type="gene ID" value="CG723_37160"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008324">
        <property type="term" value="F:cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006829">
        <property type="term" value="P:zinc ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1510.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002524">
        <property type="entry name" value="Cation_efflux"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036837">
        <property type="entry name" value="Cation_efflux_CTD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027469">
        <property type="entry name" value="Cation_efflux_TMD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040177">
        <property type="entry name" value="SLC30A9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13414">
        <property type="entry name" value="PTHR13414"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01545">
        <property type="entry name" value="Cation_efflux"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160240">
        <property type="entry name" value="SSF160240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161111">
        <property type="entry name" value="SSF161111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01297">
        <property type="entry name" value="CDF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="77"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="112"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="160"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="189"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="307"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="314"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PJN06908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="334" mass="35044" checksum="134FE57F4B757224" modified="2018-04-25" version="1">MSASGGTKAIVAALAANLAIAVAKFVAFLFSGSSSMLAESVHSLADSGNQGLLLLGGKKAQREATPQHPFGYGRERYIYAFLVSIVLFSVGGMFAVYEGYEKIKHPHALENWYWPIGVLVFAIIAESFSFRTAIKESNELRGKLTWSQFIRRAKAPELPVVLLEDFGALIGLVLALAGTGLALATDDGLWDGIGTVCIGVLLIAIAIVLAAETKSLLLGEAADVDQVKKIEAALVDGDTVTGVIHMRTLHLGPEELLVAAKIAVQHDDTATEVANAINAAEARIREAVPIARVIYLEPDIYNEAAASAGTNPAKTPAGPASDSPTPDSSGPDAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JJ74</accession>
    <name>A0A2M9JJ74_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_36910</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000025">
        <property type="protein sequence ID" value="PJN06913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN06913">
        <property type="protein sequence ID" value="PJN06913"/>
        <property type="gene ID" value="CG723_36910"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="142"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN06913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="246" mass="25925" checksum="91EDC1FC70995430" modified="2018-04-25" version="1">MLRRLAEERATGALLRDRGTLYLADGQVVHAESPATPGIDVLLTTGGTLHPDGWWEAVDAAGTRQRVGRYLVESGRLTDGALELCHLGALYDAAFFALAPSGAPARFRYGAAHWFGTVHPVSVASVEAETLRRRELLHGIRPDAATDTAPLERDGGGHSPAVPPRQRAVLALVDGARTAADISHVLGRPAFHTLVDLRRLAAAGLVRAAAPRPLPPAPAVPAWAGAASADADVALLRRLRDALEAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JJ99</accession>
    <name>A0A2M9JJ99_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 7">UDP-glucose 6-dehydrogenase</fullName>
            <ecNumber evidence="4 7">1.1.1.22</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CG723_36260</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">CB01635</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>H2O + 2 NAD(+) + UDP-alpha-D-glucose = 3 H(+) + 2 NADH + UDP-alpha-D-glucuronate</text>
            <dbReference type="Rhea" id="RHEA:23596"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:58052"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="EC" id="1.1.1.22"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Nucleotide-sugar biosynthesis; UDP-alpha-D-glucuronate biosynthesis; UDP-alpha-D-glucuronate from UDP-alpha-D-glucose: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the UDP-glucose/GDP-mannose dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.22" evidence="4 7"/>
    <dbReference type="EMBL" id="NNBL01000024">
        <property type="protein sequence ID" value="PJN06950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN06950">
        <property type="protein sequence ID" value="PJN06950"/>
        <property type="gene ID" value="CG723_36260"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00038">
        <property type="reaction ID" value="UER00491"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003979">
        <property type="term" value="F:UDP-glucose 6-dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000271">
        <property type="term" value="P:polysaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006065">
        <property type="term" value="P:UDP-glucuronate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017476">
        <property type="entry name" value="UDP-Glc/GDP-Man"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014027">
        <property type="entry name" value="UDP-Glc/GDP-Man_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036220">
        <property type="entry name" value="UDP-Glc/GDP-Man_DH_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014026">
        <property type="entry name" value="UDP-Glc/GDP-Man_DH_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001732">
        <property type="entry name" value="UDP-Glc/GDP-Man_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028357">
        <property type="entry name" value="UDPglc_DH_bac"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00984">
        <property type="entry name" value="UDPG_MGDP_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03720">
        <property type="entry name" value="UDPG_MGDP_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03721">
        <property type="entry name" value="UDPG_MGDP_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF500134">
        <property type="entry name" value="UDPglc_DH_bac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000124">
        <property type="entry name" value="UDPglc_GDPman_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00984">
        <property type="entry name" value="UDPG_MGDP_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="SSF48179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52413">
        <property type="entry name" value="SSF52413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03026">
        <property type="entry name" value="NDP-sugDHase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7 10" id="KW-0520">NAD</keyword>
    <keyword evidence="5 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UDPG_MGDP_dh_C" evidence="11">
        <location>
            <begin position="321"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="9">
        <location>
            <begin position="153"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="8">
        <location>
            <position position="264"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="30"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="35"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="86"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="122"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="156"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="208"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="261"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="267"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="328"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="335"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR000124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR500134-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR500134-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR500134-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PJN06950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="440" mass="46423" checksum="BD6445827852ED41" modified="2018-04-25" version="1">MRVSVIGCGHLGIPHAAAMAELGHEVIGVDVDQAKVDKLNAGECPIYETGLPDLLARHTQSGRLRFTTDIREAAAFAELHFIGVGTPIDADGRSYDTAQVFGAIRQLAPHLDRACTIVGKSTVTVGTTGQVTALAQRLAPAGEQVDVVWNPEFLREGHAVEDTLRPDRLIAGLTTVEAEKAIRTVYAPILDAGVPIFVTDPQTAELAKGAANTFLGLKISYINAVADMCEAAGGDVSQIVDILGIDPRIGSGGMRPGIGYGGGCLPKDVRAFTASARQLGADQAATLLRAAEEINENRTAVALGLITRALGERPVKGSRITVWGAAFKPGTNDVRESPALALSQALQQAGGIVTVHDPQAVPTAMLRNPELDYTDDLAASLDGAELVVLATEWPEYRQADPQALVGRPANPVLVDCRTTLDPDPWRSVGWTIHQLGRPGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-06-02" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JJG2</accession>
    <name>A0A2M9JJG2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_36640</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000024">
        <property type="protein sequence ID" value="PJN07010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN07010">
        <property type="protein sequence ID" value="PJN07010"/>
        <property type="gene ID" value="CG723_36640"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN07010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="147" mass="15642" checksum="CC1899BE37830B68" modified="2018-04-25" version="1">MAATWSSTLRSSSSSRPPNRLRYPSAVIRTGVRVLGDQPVDVRDPVPVAQMLRAVVVHDGGQEELRGVERVERGELCGEVPVIVDSSWLASIFLDGPPTESVDRFGFWAGSQAGQGPECRVGWAPGSTARAVMLMLAGTGKLLVSLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JJK6</accession>
    <name>A0A2M9JJK6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Small membrane hydrophobic protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_36300</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000024">
        <property type="protein sequence ID" value="PJN06957.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN06957">
        <property type="protein sequence ID" value="PJN06957"/>
        <property type="gene ID" value="CG723_36300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025363">
        <property type="entry name" value="DUF4267"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14087">
        <property type="entry name" value="DUF4267"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="48"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="76"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="101"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN06957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="141" mass="14845" checksum="939B85FB3D7495EF" modified="2018-04-25" version="1">MSLKKINTVLAAAFILFILWFGTEFILSPETTAPGYGLPSWPSGDGDGFLIIKGIRDVVLALVLGILLVTGHRRALGWALLVEALAAYGDMTNVLAHHGSVATALGVHGLTATLMVVNGLLMMRETRKVEAAPATLAPQPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-06-02" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JJS7</accession>
    <name>A0A2M9JJS7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CG723_35905</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000023">
        <property type="protein sequence ID" value="PJN07113.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN07113">
        <property type="protein sequence ID" value="PJN07113"/>
        <property type="gene ID" value="CG723_35905"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011712">
        <property type="entry name" value="Sig_transdc_His_kin_sub3_dim/P"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07730">
        <property type="entry name" value="HisKA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="98"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="122"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="405"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="domain" description="HisKA_3" evidence="3">
        <location>
            <begin position="178"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="268"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="455"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="510"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="270"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PJN07113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="532" mass="56341" checksum="E2DA918BF3C6C452" modified="2018-04-25" version="1">MRPPARSTGPLLWAALSVPAVAAERLGLNERTPLWAQLTGLAILAAATALHRTWPATAFLLAAAPGLATSTSLFTTSYGCALAAFAFLLGLRGTATGVALLSFAAVAAAGTAKIAVRQVDPAAEWLVLMGTLLFGGVFPWLIGRYWRQSRELTAAGWARAEQLEREHRIVADRARLRERARIAQDMHDSLGHELSLIALRAGALQVAPDMAEAHRTAAAELRAAASDATERLHGIVGLLREDDEPAPLAPPGESIAALIERAADSGLPVTLQDPQDTGPDPTSRTTSPNTTTRTTYRVIQEALTNAARHAPGAPVTVEHTQNEDGTTVEITNGRPRHRPGPAGSGTGLIGLRAGVAALGGSFEAGPHEEGYRVSATIPTGKTPTPETTTPGALFASARRLAHRRVGVAFGAAAAMGAVLIGGAFAWYAYTKTHAVLTPTAYTALKIGTPLEETVPRLPDRTISDPPVDRAPTPPPPGTDCRYYRASGELFAPVDHFRLCFRKNKSHELVEKSVIPKPGTADQLHRQNRKEPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-09-29" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JL52</accession>
    <name>A0A2M9JL52_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_33110</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000019">
        <property type="protein sequence ID" value="PJN07606.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN07606">
        <property type="protein sequence ID" value="PJN07606"/>
        <property type="gene ID" value="CG723_33110"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="49"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="84"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="178"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="240"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="274"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="305"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="371"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="394"/>
            <end position="413"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN07606.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="418" mass="43405" checksum="50D2DA417D2555CB" modified="2018-04-25" version="1">MAVVRDLRVLLRLRDFRRLLALRLLSQGADGVYQVALATYVVFSPEKQTSAGAIASAMAVLLLPYSVVGPFAGVLLDRWRRRQVFLYGNLLRTVLASVTAVLMLIDAPDWLFYASALCVTAVNRFILSGLSAAMPRLVDAERLVLANSVSPTAGTLAATLGGGLAFAVRLLISDSDALVVLVGAALYLCAALASLPMSAELLGPDPELVRPGLRTALSGTTQGLVSGVRHLTARPPAARALAAITLMRFCYGALTVMVLMLCRYSWSSTESDGLALLGVAVAISGAGFFAAAVVTPWAAGRLGPAGWIIVCAGAAAVLEPALGLPFAPAPMMAAAFVLGLTTQGSKIATDTVVQSSVNDGFRGRIFSVYDVLFNVAFVGAAAVAALMLPPDGQSVPLVLTVALIYAAIAGAIARFDTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JL53</accession>
    <name>A0A2M9JL53_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GNAT family N-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_33015</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000019">
        <property type="protein sequence ID" value="PJN07588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN07588">
        <property type="protein sequence ID" value="PJN07588"/>
        <property type="gene ID" value="CG723_33015"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041496">
        <property type="entry name" value="YitH_GNAT"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13673">
        <property type="entry name" value="Acetyltransf_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18014">
        <property type="entry name" value="Acetyltransf_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="9"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN07588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="288" mass="31084" checksum="8656AEBF503CFD9C" modified="2018-04-25" version="1">MSTPLLSDLPIRRLTPRDLTACADLSEDRGWPREEHKWGLLLSAGTGYGIDDPDGGLVSACVVTDYGPPSRPALSAIGMVLVAERHARRGIGRRLMQYVAEQADTTPLTLHATPYGRPLYEGLGFKVIGRAEMVRGHFTPGGRTPSVATRAATAEDLSAMLHLDAEVFGLDRTHVLTRLPAFADQLRVAEDGGELIGFAAAWPNMDTHVIGPLIARDTETAKALVTSLAAGTDRPLRTDIDVRHEELLAWMKARGVESQAFNAVMTYGAPELPGDWTRRFAPLTVAAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JL88</accession>
    <name>A0A2M9JL88_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF3566 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CG723_33245</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000019">
        <property type="protein sequence ID" value="PJN07633.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN07633">
        <property type="protein sequence ID" value="PJN07633"/>
        <property type="gene ID" value="CG723_33245"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021949">
        <property type="entry name" value="DUF3566_TM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12089">
        <property type="entry name" value="DUF3566"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="117"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="176"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="domain" description="DUF3566" evidence="3">
        <location>
            <begin position="100"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="17"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PJN07633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="220" mass="22602" checksum="D9DB16CE68D73F42" modified="2018-04-25" version="1">MSGATGAGPTGTETDGGRGPATDSNDSNESHGSQGGTVTDTRGPQAQQYAAGTDGALPGERQQPPQSSQPYHPPQAYQAAPPAGAVRRPRTGARTTPRTRKARLRVAKADPWSVMKVSFLLSIALGICTIVAAAVLWMVMDAMGVFSTVGGTISEATGSNESNGFDLQSFLSLPRVLIFTSIIAVIDVVLATALATLGAFIYNLSAGLVGGVELTLAEDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JLI3</accession>
    <name>A0A2M9JLI3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Pyridoxamine 5'-phosphate oxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_32210</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000018">
        <property type="protein sequence ID" value="PJN07736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN07736">
        <property type="protein sequence ID" value="PJN07736"/>
        <property type="gene ID" value="CG723_32210"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011576">
        <property type="entry name" value="Pyridox_Oxase_put"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01243">
        <property type="entry name" value="Putative_PNPOx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Putative_PNPOx" evidence="1">
        <location>
            <begin position="9"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN07736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="195" mass="21762" checksum="2C94BD12F3573243" modified="2018-04-25" version="1">MGKTYERIDGRLRTFIEAQPMFFTATAPLSEGGTVNLSPKGLTGSFAVLDERTVAYLDFAGSTAETIAHLRENGRITLMWCAFQGPPNIVRVHGHGEPVFRDDARFKELLEHFPHIDPTRHGLRAIIVVTAELVRDSCGYAVPFMSYDADRDLHGKRFAREDDASLSEYFKKKEHIEHSIDGLPGLPLPLPPTTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JLQ1</accession>
    <name>A0A2M9JLQ1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Dynein regulation protein LC7</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_32505</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000018">
        <property type="protein sequence ID" value="PJN07788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN07788">
        <property type="protein sequence ID" value="PJN07788"/>
        <property type="gene ID" value="CG723_32505"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004942">
        <property type="entry name" value="Roadblock/LAMTOR2_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03259">
        <property type="entry name" value="Robl_LC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00960">
        <property type="entry name" value="Robl_LC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Robl_LC7" evidence="1">
        <location>
            <begin position="9"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN07788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="135" mass="14312" checksum="D8D65AF5E5E3F69C" modified="2018-04-25" version="1">MIQQRANFDWMLKELADGVPQTRQVVVLSADGLRIARYGGDPDAADRIAAACAGLQSLATAVASEIPDSDGRMSMVIIEVSGGFFYLMAAGKGAYLAVLADAHVDAGLISNRMRDLVVRIGAHLTSPPRRNGQTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JLR3</accession>
    <name>A0A2M9JLR3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ABC transporter substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_32650</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000018">
        <property type="protein sequence ID" value="PJN07815.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN07815">
        <property type="protein sequence ID" value="PJN07815"/>
        <property type="gene ID" value="CG723_32650"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042597">
        <property type="term" value="C:periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030678">
        <property type="entry name" value="Peptide/Ni-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039424">
        <property type="entry name" value="SBP_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000914">
        <property type="entry name" value="SBP_5_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30290">
        <property type="entry name" value="PTHR30290"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00496">
        <property type="entry name" value="SBP_bac_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002741">
        <property type="entry name" value="MppA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SBP_bac_5" evidence="1">
        <location>
            <begin position="79"/>
            <end position="445"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN07815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="529" mass="56830" checksum="5A309D0FFBB69EC1" modified="2018-04-25" version="1">MRMRNQWLVLPLGTGLTAALLAGCGTDQGDAAGQGGAVVMGMSDDIQATDPASGYDPGSWLLFNNVFQSLLSFPKGSTEPEPEAAKECSFTDSGTRVYSCTLRDGLTFSNGHKLTSKDVKFSFDRMMNIGDDAGPAIMFPMLDKVETPNAKTVVFKLKHADATFPSKIASGAGSIVDHAAYSMDGLRTDGKAVGSGPYKLDSFDKKKAVFSVNPDYKGTAKVQNSGMTIKFFHGDQAGLKKALVGGDIDLAYRGLAAKDIAGIENSTSTSKPMDVVEGTSAEVQHLVFNMKDPVAGRLSVRKAMAYLIDRDALVDEVYQDTATPLYSIIPAGISGHNTAFFDTYGAHPSPAKARAALRADGITGKVKITLWSTPSRYGPATDQELAAVAKQLNASGLFEADMKSIEFGQYEKDIKTGKYGVYVKGWVPDYPDPDNFTQPFFGAGNVLGNNYTNSTITGKIIPETGAQSDRASTDRDFEQLQNIVADELPVLPVWQAKQYAVVRDSVYGLESCLDASTVFRFWEISKGTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-09-29" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JME4</accession>
    <name>A0A2M9JME4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Acyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_30560</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000016">
        <property type="protein sequence ID" value="PJN08032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08032">
        <property type="protein sequence ID" value="PJN08032"/>
        <property type="gene ID" value="CG723_30560"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002656">
        <property type="entry name" value="Acyl_transf_3_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01757">
        <property type="entry name" value="Acyl_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="45"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="88"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="126"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="153"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="182"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="214"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="251"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="288"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="329"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl_transf_3" evidence="2">
        <location>
            <begin position="24"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN08032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="362" mass="41204" checksum="B7DB77E05FC6A656" modified="2018-04-25" version="1">MIEPGDREPAVPERSAVRAGGRDRYFDTLRALALVRVVAYHTFGWVWAGLFFPSMGVMFALAGSLMAKSLERPALSVIRGRTRRLLPPFWLWGIFVVLAMLLHGWMPGWQVVYWVVPLGDPPGNSWGMQAWEILWYLRAYLWFVLLSPLLLKVFRLAPVAVLLASLTPILVLQFVWQPPDNRFGSGLLDFATFLFCWLAGFAHREGVLARLRPGPVVVLSIAALAYGAWFALTHQAEYGSYDLDDIPLAQAFWSAGFVMLLMYSKAYFKVDFAWLARFKRLDRIVSVFNARAMTIYLWHEIALILAVPLIDQFWNVPAFVKYLPLESQWFMFGVGWVLIAAAIPLVGWVEDVAAKRRPRLLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JMZ0</accession>
    <name>A0A2M9JMZ0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Peptide ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CG723_29675</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000015">
        <property type="protein sequence ID" value="PJN08177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08177">
        <property type="protein sequence ID" value="PJN08177"/>
        <property type="gene ID" value="CG723_29675"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015833">
        <property type="term" value="P:peptide transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013563">
        <property type="entry name" value="Oligopep_ABC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08352">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01727">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="21"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="65"/>
            <end position="72"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PJN08177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="357" mass="39348" checksum="4D1F839704707458" modified="2018-04-25" version="1">MADLAKEAHAAAPVPAREPILEVSGLVKHYPLTQGILFKKQVGAVKAVDGVDFVLGEGETLGIVGESGCGKSTVARMLVNLERPTAGQIKYRGEDITKLSGRALKAVRRNIQMVFQDPYTSLNPRMTVGDIIGEPYEIHPEVAPKGDRRRKVQDLLDVVGLNPEYINRYPHQFSGGQRQRIGIARGLALRPEIIVADEPVSALDVSVQAQVINLLDSLQNEFDLSYVFIAHDLSIVRHISDRVGVMYLGRIVETGTDEQIYEHPTHPYTQALLSAVPVPDPEAREHRERIILTGDVPSPANVPSGCRFRTRCWKAQERCELEVPALAVPAVFRIGESPAKHDSACHFAEEKRVVPSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JN06</accession>
    <name>A0A2M9JN06_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Peptidase M20</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_30000</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000015">
        <property type="protein sequence ID" value="PJN08235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08235">
        <property type="protein sequence ID" value="PJN08235"/>
        <property type="gene ID" value="CG723_30000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002933">
        <property type="entry name" value="Peptidase_M20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011650">
        <property type="entry name" value="Peptidase_M20_dimer"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07687">
        <property type="entry name" value="M20_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01546">
        <property type="entry name" value="Peptidase_M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="M20_dimer" evidence="1">
        <location>
            <begin position="204"/>
            <end position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN08235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="470" mass="50879" checksum="73C119595C3C0C12" modified="2018-04-25" version="1">MSKPVDNAVSAVRAYIDTHHDAFLQDLAEWLRIPSVSAQPDHAPDVRRSADWLAVKLRETGFPTTEVWETPGAPAVFADWPCDDPHAPTVLVYGHHDVQPAAREDGWNTDPFEPVVIGNRLHARGAADDKGQVFFHTLGVRAHLAATGRTTPAVHLKLLVEGEEESGSPHFRALVEQHRDRLTADAVIVSDTGMWSEDTPTVCTGMRGLADCEIELHGPDQDIHSGSFGGAVPNPATAAARLVAALHDDHARVAVPGFYDGITPLTDRERELFAELPFDEAQWLRTAKSHATHGEAGHTTLERIWARPTAEVNGIGGGYQGPGGKTIVPSSATLKLSFRLVAGQDPDHVEKAITDWVAQQLPAGIRHTVTFGAATRPCLTPLDHPALQSVVRAMNLAFDQKIRFTREGGSGPAADLQDVLDAPVLFLGISVPSDGWHAPNEKVELDLLKKGVETAAHLWGDLAENWRDAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JN51</accession>
    <name>A0A2M9JN51_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Phosphotyrosine protein phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_28295</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000014">
        <property type="protein sequence ID" value="PJN08302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08302">
        <property type="protein sequence ID" value="PJN08302"/>
        <property type="gene ID" value="CG723_28295"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023485">
        <property type="entry name" value="Ptyr_pPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036196">
        <property type="entry name" value="Ptyr_pPase_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01451">
        <property type="entry name" value="LMWPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00226">
        <property type="entry name" value="LMWPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52788">
        <property type="entry name" value="SSF52788"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LMWPc" evidence="1">
        <location>
            <begin position="6"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN08302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="135" mass="14154" checksum="1A7C515AF065AA3B" modified="2018-04-25" version="1">MPDPKPSVLFVCVHNAGRSQMAAAWLTHLAGDRVEVRSAGSAPADTINPAVVEAMHEAGIDISAEAPKILTVEAVQASDVVITMGCGDTCPVFPGKRYLDWKLDDPAGQGVAAVRPIRDAIESLVQGLITEIAPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JN85</accession>
    <name>A0A2M9JN85_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Tyrosinase co-factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_28455</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000014">
        <property type="protein sequence ID" value="PJN08324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08324">
        <property type="protein sequence ID" value="PJN08324"/>
        <property type="gene ID" value="CG723_28455"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042438">
        <property type="term" value="P:melanin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1880.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023199">
        <property type="entry name" value="GriE/MELC1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010928">
        <property type="entry name" value="MelC1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06236">
        <property type="entry name" value="MelC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="74"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN08324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="149" mass="16198" checksum="1B6D884B6F9ECDA5" modified="2018-04-25" version="1">MEAGTPPVGLGPAGRVVVTRRSAVRRLIGVALAAAVVPAAALVGRAFREPHDDLRDASGKDFEETYRGRHIRGTRGQGSMMRGHLGQKPGQRSGRWDVTVDGRPLHLMRRADGSYLSMVDHYQSYPTPLAAARGAVDELGHQILRRQVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JNZ4</accession>
    <name>A0A2M9JNZ4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CG723_27925</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000013">
        <property type="protein sequence ID" value="PJN08591.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08591">
        <property type="protein sequence ID" value="PJN08591"/>
        <property type="gene ID" value="CG723_27925"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PJN08591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="93" mass="10803" checksum="55746A5C2495B020" modified="2018-04-25" version="1">MSLPFGPDRQTREFECECCNAPIERAWNFICSDGEPYAVYFANCYHHRDRDHDAWIDVIFGTWGTGQMPGLITSRSHAVSDPWPGRRLQLRRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JP99</accession>
    <name>A0A2M9JP99_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Aldehyde dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CG723_26730</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000012">
        <property type="protein sequence ID" value="PJN08694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08694">
        <property type="protein sequence ID" value="PJN08694"/>
        <property type="gene ID" value="CG723_26730"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016620">
        <property type="term" value="F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016160">
        <property type="entry name" value="Ald_DH_CS_CYS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="SSF53720"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00070">
        <property type="entry name" value="ALDEHYDE_DEHYDR_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldedh" evidence="3">
        <location>
            <begin position="13"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PJN08694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="488" mass="51159" checksum="D56CAC2A1651907D" modified="2018-04-25" version="1">MDDSQRLFIGGEWTEPDGGHYEVVDPASEEVVGLAPEASRAQVHDAASAAREAFGSWSRTKPEERAAILDRAADVMQRDFAANAELAQAESGATSGTARGMQVAVGVARFRRYAKGALEPVEQALPPQISEAGPMGKAGVLGALAVRQPVGVVTCITSYNNPWANPAGKVAPALAMGNTVVVKPAPQDPLSVYRMAAALEEAGAPPGVVNVVSGTAVDVGEAAVDSPDVDMVSFTGSTAVGRRIGEVCGRGMKRQLMELGGKGAALVFDDLDEAGLASAVAGIGTTYAFYSGQICTAPTRVIAQRGVYDALVSKLTEYIGFMKVGDPRARGTVVGPVISAAHRDRVESYVELGRKEGARVVAGGERPALDKGFYVAPALLADCRDDMRVVREEIFGPVVVVVPFDEEEEGVALANDSEYGLIDYVWSGDVARAFRVARRLRAGGVGVNTVGRNMEAPFGGFKQSGVGRDVGSYALHAYSELQSIVWQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JPB7</accession>
    <name>A0A2M9JPB7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">TetR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_26870</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000012">
        <property type="protein sequence ID" value="PJN08714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08714">
        <property type="protein sequence ID" value="PJN08714"/>
        <property type="gene ID" value="CG723_26870"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="10"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="32"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN08714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="190" mass="20356" checksum="C9063404A62336CE" modified="2018-04-25" version="1">MGRVSHAQAQANRQRVVEQASQLFREQGTGVSVADLMKAAGLTHGGFYKQFASKEALIDEAVVHAVGELAERHATTLEEHEGHRVEAQQALIDGYLSVRHRDNPASGCPVAALATDMARTSGDRGAHRAYTEGVQDFTQWLATDDEDGIARLCTMLGALLLARATKDSPLSEQVLSAARTALSPAPQARV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JPJ2</accession>
    <name>A0A2M9JPJ2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CG723_26805</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CB01635</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000012">
        <property type="protein sequence ID" value="PJN08707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08707">
        <property type="protein sequence ID" value="PJN08707"/>
        <property type="gene ID" value="CG723_26805"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043231">
        <property type="term" value="C:intracellular membrane-bounded organelle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070273">
        <property type="term" value="F:phosphatidylinositol-4-phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3630.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008628">
        <property type="entry name" value="GPP34-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038261">
        <property type="entry name" value="GPP34-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12704">
        <property type="entry name" value="PTHR12704"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05719">
        <property type="entry name" value="GPP34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="207"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PJN08707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="243" mass="25799" checksum="56A5FC05614EE4CB" modified="2018-04-25" version="1">MGRSRRTIPEELLLLALDPATGTTAQPQSLDLGLAGAQLVELALAGRIAPDGDRIAVVAPRPTGDPTLDCALELLRRRGTPVRAVHWIGGPRLGLRQTYLSHLERCGMVHAVAGQMCGVLPTTRYQATETAISREIRSRLDTAIRTGVPPDPRTAALAALAHAVGLGKHLYPGNEGRSSRSRLRDLIRHDPMGGLVAHAVMDVQNGVAAQPRRSPAPPGRGAPEPGRVPMQPHHGSMARAVAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JPK0</accession>
    <name>A0A2M9JPK0_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 10">Phosphoenolpyruvate carboxylase</fullName>
            <shortName evidence="10">PEPC</shortName>
            <shortName evidence="10">PEPCase</shortName>
            <ecNumber evidence="5 10">4.1.1.31</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">ppc</name>
        <name evidence="13" type="ORF">CG723_27305</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">CB01635</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3 10">Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>oxaloacetate + phosphate = hydrogencarbonate + phosphoenolpyruvate</text>
            <dbReference type="Rhea" id="RHEA:28370"/>
            <dbReference type="ChEBI" id="CHEBI:16452"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="EC" id="4.1.1.31"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 10">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="10">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 10">Belongs to the PEPCase type 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.31" evidence="5 10"/>
    <dbReference type="EMBL" id="NNBL01000012">
        <property type="protein sequence ID" value="PJN08786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08786">
        <property type="protein sequence ID" value="PJN08786"/>
        <property type="gene ID" value="CG723_27305"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008964">
        <property type="term" value="F:phosphoenolpyruvate carboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015977">
        <property type="term" value="P:carbon fixation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006107">
        <property type="term" value="P:oxaloacetate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00595">
        <property type="entry name" value="PEPcase_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021135">
        <property type="entry name" value="PEP_COase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022805">
        <property type="entry name" value="PEP_COase_bac/pln-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018129">
        <property type="entry name" value="PEP_COase_Lys_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033129">
        <property type="entry name" value="PEPCASE_His_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_Kinase-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30523">
        <property type="entry name" value="PTHR30523"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00311">
        <property type="entry name" value="PEPcase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00150">
        <property type="entry name" value="PEPCARBXLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="SSF51621"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00781">
        <property type="entry name" value="PEPCASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00393">
        <property type="entry name" value="PEPCASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0120">Carbon dioxide fixation</keyword>
    <keyword evidence="8 10" id="KW-0456">Lyase</keyword>
    <keyword evidence="7 10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="13" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" evidence="10 11">
        <location>
            <position position="138"/>
        </location>
    </feature>
    <feature type="active site" evidence="10 12">
        <location>
            <position position="570"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00003670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022419"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00595"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PJN08786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="912" mass="101604" checksum="49A25B10F567F3B6" modified="2018-04-25" version="1">MSSADDQSREATSSAELRADIRRLGDLLGETLVRQEGPELLELVEKVRRLTREDGEAAARLLGDTELETAAKLVRAFSTYFHLANVTEQVHRGRELRARRAAEGSLLARTADRLKDADAEHLRETVQHLNVRPVFTAHPTEAARRSVLNKLRRVAELLETPVIEADRRRYDTRLAENIDLVWQTDELRVVRPEPTDEARNAIYYLDELHAGAVGDVLEDLTAELQRVGVTLPDATRPLTFGTWIGGDRDGNPNVTPAVTWDVLILQHEHGINDALELIDELRGFLSNSIRYTGATEELLTSLQNDLERLPEISPRYKRLNSEEPYRLKATCIRQKLENTKERLAKGTAHDDGRDYLGTGELLHDLTLIQTSLREHRGALFADGRMNRTIRTLAAFGLQLATMDVREHADAHHHALGQLFDRLGEESWRYADMPREYRQKLLAKELRSRRPLAPSPAPLDAAGEKTLGVFHTVKRALDVFGPEVIESYIISMCQGADDVFAAAVLAREAGLIDLHGGWAKIGIVPLLETTDELRAADVILDEMLADPSYRRLVALRGDVQEVMLGYSDSSKFGGITTSQWEIHRAQRRLRDVAHRYGVRLRLFHGRGGTVGRGGGPSHDAILAQPWGTLEGEIKVTEQGEVISDKYLVPSLARENLELTVAATLQASALHTAPRQSDESLARWDAAMDVVSDAAHAAYRKLVEDPDLPTYFLASTPVDQLADLHLGSRPSRRPGSGVSLDGLRAIPWVFGWTQSRQIVPGWFGVGSGLKALREAGLGTVLDEMSEHWHFFRNFLSNVEMTLAKTDLRIARHYVDTLVPDELKHVFADIEAEHELTVREVLRITGGQELLDTQPVLQQTFSIRDAYLDPISYLQVALLKRQRDEAAAGNEPDPLLGRALLLTVNGVAAGLRNTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JPP5</accession>
    <name>A0A2M9JPP5_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Histidine kinase</fullName>
            <ecNumber evidence="3">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CG723_25490</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">CB01635</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="3"/>
    <dbReference type="EMBL" id="NNBL01000011">
        <property type="protein sequence ID" value="PJN08853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08853">
        <property type="protein sequence ID" value="PJN08853"/>
        <property type="gene ID" value="CG723_25490"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00672">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00304">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 12" id="KW-0418">Kinase</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014631259" description="Histidine kinase" evidence="9">
        <location>
            <begin position="45"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="195"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="11">
        <location>
            <begin position="219"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="10">
        <location>
            <begin position="281"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="95"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PJN08853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="486" mass="50846" checksum="6DA03956846693DD" modified="2018-04-25" version="1">MRRRLFGSVRARATLGATLVVAVALLAAGASVLLALRSNLTDQASSEAESSARKVAVSIATGTAPNGLDLPDGDDTPVQVVDGDGRLLAASEDLERISGTGSPAVRPVTPPVDDDGGDDDDGGSDRHGGKGGEDDSYAYGEIADDAERSEGSATVDGETRDYRFASLEVKKTRQGDLTVYAGASLSAEQSAVGTALTVMLIGFPVLLGVVAAVTWLVTRRALRPVEGIRREMSAITASQDLARRVPEPGTHDEVARLARTTNETLAALETSVERQRRFVADASHELRSPIASLRTQLEVGAAHPELLDVDGAVADTVRLQELAAGLLLLARLDAGERPGEARVDLAALAGEELSQRPPGRVAVRTRLEPVEVAGSRSQLARVVGNLLDNAQRHARSRVDIAVRAEGPWAVVEVGDDGAGVPEAERERIFERFVRLDDARARDDGGAGLGLAIARDVAVRHGGALTVRSSPAGGALFELRLPVAPGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JPZ5</accession>
    <name>A0A2M9JPZ5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CG723_26075</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000011">
        <property type="protein sequence ID" value="PJN08953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08953">
        <property type="protein sequence ID" value="PJN08953"/>
        <property type="gene ID" value="CG723_26075"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PJN08953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="298" mass="34086" checksum="85C9540B65F611AA" modified="2018-04-25" version="1">MAVVLLAGCDVSPSGVRRTADGVPIVREAKDRPELPLHRYEFTAEDDGAFGTLKRAQKLLAQRCMRDFGFADFPRDPKNPNPGGLAMVAVSQDLDGQLDLEKARRWGYGWDPQRDVRIEPEGRRMTAEESRVYWGHRTGGKPTVLGKRVPQEGCLGRADKRLYRGVRDLRRAWGYVPQREIVLEKAAAKDRRMRRVLKVWSQCVVDKGFKRYGTPDDAFRDKAWKRDRGGNTARTRRERGTAVADVECKREHNTAGVWWSVLSERQRADLGRHRSAYEAARRDQETVRDNVREVLADT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-09-29" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JQ35</accession>
    <name>A0A2M9JQ35_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Metal-dependent phosphohydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CG723_26265</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000011">
        <property type="protein sequence ID" value="PJN08988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08988">
        <property type="protein sequence ID" value="PJN08988"/>
        <property type="gene ID" value="CG723_26265"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00077">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006674">
        <property type="entry name" value="HD_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01966">
        <property type="entry name" value="HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="122"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="183"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="230"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="domain" description="HD" evidence="3">
        <location>
            <begin position="299"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PJN08988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="452" mass="46656" checksum="5E8A402F504963AD" modified="2018-04-25" version="1">MEPRGDRGRGRRAGARAPRHAAGGSAVTWRRSPGPGSGRARTTIAAVQGLAVVLSAASLGATLWKGLEEPGTALAFGVLIAVGELARWGAPGKDREPAPLGVAGALAYALLGETAGQATHHGALQVVAVCVAAALVGSVPHLAVGRGPSADHMARRVLTVAFAAVCFQPLYNEGRFGAWLGDGAAYALLLVGLLVLTALCDAVLAAAMAHARTGWPFGPLLRDELRAMSGIGSAVCATGAVIALAVAVAGLWALPVFCLPLLLTQLAFRRYAAVRTTYRQTIASLARATEIAGYTPQGHALRVAALSRAVGRELGLSEPDLTVLEYAALMHDIGQLSLVDPVADGATAALPAQEQRRIALLGGAVVRQTGVDAEVAVVVERQADPYREQPLTARIVRTANAYDEMARGEGPQGPLTALERLRLATGRDYQPDVVESLARVVSRGGVTLPPAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-05-25" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JQY1</accession>
    <name>A0A2M9JQY1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Branched-chain amino acid ABC transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CG723_23285</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CB01635</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the leucine-binding protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000009">
        <property type="protein sequence ID" value="PJN09278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN09278">
        <property type="protein sequence ID" value="PJN09278"/>
        <property type="gene ID" value="CG723_23285"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006865">
        <property type="term" value="P:amino acid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028081">
        <property type="entry name" value="Leu-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000709">
        <property type="entry name" value="Leu_Ile_Val-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13458">
        <property type="entry name" value="Peripla_BP_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00337">
        <property type="entry name" value="LEUILEVALBP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014799566" evidence="3">
        <location>
            <begin position="24"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="domain" description="Peripla_BP_6" evidence="4">
        <location>
            <begin position="38"/>
            <end position="381"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PJN09278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="397" mass="42266" checksum="EB0EBA385E853265" modified="2018-04-25" version="1">MRRRTTRALIAALAAMLAVVASACGTKNPSAAGDDKVIKIGAWYPLTGALASFGIPERAGADAYFKSVNARGGINGRKIDWVVKDSAFDPQQTVQVARRLVDQDGVVAIVAANGTAQSQATFPFVLDQKKVPVLNPLGGDATWYQPARDGLFGLQTLYEDQAAALGDWVARDGAKKVLVVHSDPAAFVNVAKEIGPAARKADPSVRVKRLKVKFQTSDYSPVISKVKAEKPDAVVLILASAEAASYLKEAKLQGLSTPVYGYAPVAAQSTLTLAGKAAEGVRAVQLVKSPNDDDPAVEEFRTAMAKYEKGQPADFITLWGWEAAKAFVEIAKTIDGPVTSEALTAAYEKAKAVDTGVGPVLNFSPDNHLGTRDVQKVVVRNGRWESQGDFFTPPTRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JR17</accession>
    <name>A0A2M9JR17_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">2,4-dienoyl-CoA reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CG723_23365</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CB01635</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">In the N-terminal section; belongs to the NADH:flavin oxidoreductase/NADH oxidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000009">
        <property type="protein sequence ID" value="PJN09294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN09294">
        <property type="protein sequence ID" value="PJN09294"/>
        <property type="gene ID" value="CG723_23365"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001155">
        <property type="entry name" value="OxRdtase_FMN_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00724">
        <property type="entry name" value="Oxidored_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Oxidored_FMN" evidence="2">
        <location>
            <begin position="10"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="domain" description="Pyr_redox_2" evidence="3">
        <location>
            <begin position="383"/>
            <end position="605"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PJN09294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="653" mass="68147" checksum="04F5FA5CE0D8CBA3" modified="2018-04-25" version="1">MTHPTDLALAAPFTLGALTLRNRLVATAHATAAVADGAPTEADATYWRRLAQGGAAMVITGGTAVAPESTLPQRYLTEAWRPEIEDAVRRRAEAITDGGAVAIAQLVHLGRETLGAGTYYAPVSAAAVRSPREASAPHALSTEEVRGVVDAFRISAANSVQAGFHGVELHAGHGYLLAQFLSGVNNTRDDDYGDRIALLAQVIDAIRTEIGQLPIGVRVSVEPGKDSGLGLDDLVELLPRLIAASPFTYANVTTGVRNTYVPGMATTRPPLLDAVARLRAAVALPLLVSQGFRAAHDIERALDAGADLVGMARPFIADPDFARKMTVGNERSIRPCTGCNEGCRTFEPTGSCSVNPELGPPGAAARPAVPLLLTRRPGHRSGSVAVLGAGPAGMECAMALARTGATVVVFDSAREVGGQARLAALAAHRPGWQKLVDFQRDRLADLGVRVRLGTSPTAGELAEYAHIVLATGAEETTVPMPGELRTLTSTDFLGRYADVVPQAPRVAVLDDGFGWWQGVSAVESALAAGAREVTLITPGNGFATGLSPENRTQLMNRLTGAPLRVVAMSGVTSTTGDGVRLRHVLDGQETDLAADLLVTVGERRPRRPDFTPADGQSVRAVGDCVVPRRITHAVAEGRAAAEAVAAGPLPAMP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JR35</accession>
    <name>A0A2M9JR35_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Flavoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CG723_23670</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000009">
        <property type="protein sequence ID" value="PJN09339.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN09339">
        <property type="protein sequence ID" value="PJN09339"/>
        <property type="gene ID" value="CG723_23670"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PJN09339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="457" mass="47297" checksum="04CE67DB1BAE3A96" modified="2018-04-25" version="1">MSEQQLPVVVIGTGPAGLAAAAHLHERGIGHLVLESGPAAASAVREWSHVRLFSTWGELVDPAAEKLLAPTGWTKPDAAAYPTGGDWADEYLQPLADALGEQVRYEATVTGVSRAGRDRIVDADRESQPFVVHFTTPAGEERAFASAVIDASGTWTTPSPAGASGLPALGETTAADRITYRVPDLKDPAVRARYAGKRTAVIGSGASAFTALASLAELAKDDAGAHAVWILRRGISGSTFGGGSADQLPARGALGLAAKAAVDNGYADAVTGFRTEAVERDADGRLILVGEDSRRLDPVDEVIVLTGLRPDLSFLSELRLGLDERLQAPVELAPLIDPNQHSCGTVYPHGHRELSHPEQDIYLVGMKSYGRAPTFLAMTGYEQVRSVVAAIAGDTESADHVELTLPETGVCGGAGLFDDPAAEQSEGGGCCAPAPAVVQISVGAGAALTVEESSSGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JRA7</accession>
    <name>A0A2M9JRA7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CG723_24120</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000009">
        <property type="protein sequence ID" value="PJN09411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN09411">
        <property type="protein sequence ID" value="PJN09411"/>
        <property type="gene ID" value="CG723_24120"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00118">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018392">
        <property type="entry name" value="LysM_dom"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PJN09411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="110" mass="11848" checksum="4069744670BECBB1" modified="2018-04-25" version="1">MFDPTSRYHGIATTTLTTPDGRTVTYVRRRFLPQPGDLTSVGVQVVAPGDRLDRIAARQYGDPEQAWRIADANGAMRPEDLTAVPGRRLRIALLAGVPGSLTMATTPATS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JRK3</accession>
    <name>A0A2M9JRK3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_22170</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000008">
        <property type="protein sequence ID" value="PJN09478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN09478">
        <property type="protein sequence ID" value="PJN09478"/>
        <property type="gene ID" value="CG723_22170"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="28"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN09478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="59" mass="6281" checksum="DCE47EAEB425302E" modified="2018-04-25" version="1">MFAIASAVLFFLAFLINAADIATNDVFSSVNVMLLGLTALALHLAGAGGWARTRTSRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JRY0</accession>
    <name>A0A2M9JRY0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_23095</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000008">
        <property type="protein sequence ID" value="PJN09614.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN09614">
        <property type="protein sequence ID" value="PJN09614"/>
        <property type="gene ID" value="CG723_23095"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014618173" evidence="1">
        <location>
            <begin position="39"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN09614.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="244" mass="25461" checksum="27A6C9BF0183D94C" modified="2018-04-25" version="1">MPLRDQDSALSRRRFLAAGAACAGALAVPAAVAPPAAAATRYTLTATNNSNQFQDLCLFQKTVGLGVPSALSLAWLTAPAQPGHTVTFTWSVDYSFVWAVTGPLMSGIPFMDRELVAADPDDELENQTGFDFDNGNYGFVPASGSGTPLGGLGIQVLPSVPDDTASVGIGMDGAPVFAAQAVPGAKLVFTPHAQYWITAGTFSNGEVLDVEEITNDVEIPYDDTFSMNAVLGPNNLWTVSASKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JS50</accession>
    <name>A0A2M9JS50_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GNAT family N-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_22350</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000008">
        <property type="protein sequence ID" value="PJN09627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN09627">
        <property type="protein sequence ID" value="PJN09627"/>
        <property type="gene ID" value="CG723_22350"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13302">
        <property type="entry name" value="Acetyltransf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="16"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN09627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="167" mass="18292" checksum="B23A5DC22E3D2A9D" modified="2018-04-25" version="1">MSTYETMSFHLQTERLTLRPWAESDAAELCALVSERGKGAPTVEHTRTSIAELLTATATTGIALLPIQRRAEGDFIGYCGLTIGRSTLEEPEIAYELFQHAHGRGYATEAAGAVLDAAVATGRKRLWATVGAWNAPSFRVLEKLEFERDHVSTDDSGEVVWLTRSLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JS51</accession>
    <name>A0A2M9JS51_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cell division initiation protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_21120</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000007">
        <property type="protein sequence ID" value="PJN09706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN09706">
        <property type="protein sequence ID" value="PJN09706"/>
        <property type="gene ID" value="CG723_21120"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3" id="KW-0132">Cell division</keyword>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="140"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="298"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="94"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="157"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="301"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="342"/>
            <end position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN09706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="363" mass="40010" checksum="FA98DB229221F998" modified="2018-04-25" version="1">MDVQKKLDEIVAAVGNARSMPMSASCVVNRADLLAMLEEVRQALPGSLAQAEELIGGREQMVEQARQEADRIIETAHAERGSLISDTEVARRSQDEGERILTEARKEAEEIRAEADDYVDSKLANFEVVLTKTLGSVGRGREKLLGTGPGLDAQGYEDEDAPERSHDPETLRRDADSYVDVKLGAFEAVLAKTLEAVGRGRHTLQGRVASDELGTLGADGTGGQHTSDADYLAGLAEIGNAPAEPEREIPQAPQIQTPQIPAQQPVYATQQHDPQQDLYGYQQHQQQPYGQQDPYAVYQQDPYAYQQQDPYAYQQHQQQGYDQGQAGYAQPQVAHEPTALDETSLFDTSMISTEQLRQYEQGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JSF6</accession>
    <name>A0A2M9JSF6_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Riboflavin biosynthesis protein</fullName>
        </recommendedName>
        <domain>
            <recommendedName>
                <fullName evidence="11">Riboflavin kinase</fullName>
                <ecNumber evidence="11">2.7.1.26</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="11">Flavokinase</fullName>
            </alternativeName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="11">FMN adenylyltransferase</fullName>
                <ecNumber evidence="11">2.7.7.2</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="11">FAD pyrophosphorylase</fullName>
            </alternativeName>
            <alternativeName>
                <fullName evidence="11">FAD synthase</fullName>
            </alternativeName>
        </domain>
    </protein>
    <gene>
        <name evidence="13" type="primary">ribF</name>
        <name evidence="13" type="ORF">CG723_21675</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">CB01635</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2 11">
            <text>ATP + FMN + H(+) = diphosphate + FAD</text>
            <dbReference type="Rhea" id="RHEA:17237"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
            <dbReference type="EC" id="2.7.7.2"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>ATP + riboflavin = ADP + FMN + H(+)</text>
            <dbReference type="Rhea" id="RHEA:14357"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57986"/>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.26"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 11">Cofactor biosynthesis; FAD biosynthesis; FAD from FMN: step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4 11">Cofactor biosynthesis; FMN biosynthesis; FMN from riboflavin (ATP route): step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the ribF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.26" evidence="11"/>
    <dbReference type="EC" id="2.7.7.2" evidence="11"/>
    <dbReference type="EMBL" id="NNBL01000007">
        <property type="protein sequence ID" value="PJN09806.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN09806">
        <property type="protein sequence ID" value="PJN09806"/>
        <property type="gene ID" value="CG723_21675"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00276">
        <property type="reaction ID" value="UER00406"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00277">
        <property type="reaction ID" value="UER00407"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003919">
        <property type="term" value="F:FMN adenylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008531">
        <property type="term" value="F:riboflavin kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006747">
        <property type="term" value="P:FAD biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009398">
        <property type="term" value="P:FMN biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009231">
        <property type="term" value="P:riboflavin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02064">
        <property type="entry name" value="FAD_synthetase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015864">
        <property type="entry name" value="FAD_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023468">
        <property type="entry name" value="Riboflavin_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002606">
        <property type="entry name" value="Riboflavin_kinase_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015865">
        <property type="entry name" value="Riboflavin_kinase_bac/euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023465">
        <property type="entry name" value="Riboflavin_kinase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22749">
        <property type="entry name" value="PTHR22749"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06574">
        <property type="entry name" value="FAD_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01687">
        <property type="entry name" value="Flavokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004491">
        <property type="entry name" value="FAD_Synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00904">
        <property type="entry name" value="Flavokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82114">
        <property type="entry name" value="SSF82114"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00083">
        <property type="entry name" value="ribF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9 11" id="KW-0274">FAD</keyword>
    <keyword evidence="5 11" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6 11" id="KW-0288">FMN</keyword>
    <keyword evidence="11" id="KW-0418">Kinase</keyword>
    <keyword evidence="8 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Flavokinase" evidence="12">
        <location>
            <begin position="187"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR004491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PJN09806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="317" mass="34530" checksum="FF783626496AF334" modified="2018-04-25" version="1">MQRWRGLEDIPQDWGRSVVTIGSYDGVHRGHQLIIGRAVERARELGVPAVVVTFDPHPSEVVRPGSHPPLLAPHHRRAELMAELGVDALLILPFTTEFSKLSPADFVAKVLVDKLHARLVVEGPNFRFGHRAAGNVAFLAEQGTTYDFEVEVVDLYVSGSAGGGEPFSSTLTRRLVAEGDMEGAREILGRPHRVEGVVVRGAQRGRELGFPTANVETLPHTAIPADGVYAGWLHVGDEAMPAAISVGTNPQFDGTERTVEAYAIDRVDLDLYGLHVAVDFLAYVRGMAKFDSIESLLVAIADDVKRSRELVEAYEGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JSK9</accession>
    <name>A0A2M9JSK9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Gamma-glutamylcyclotransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_19180</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000006">
        <property type="protein sequence ID" value="PJN09869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN09869">
        <property type="protein sequence ID" value="PJN09869"/>
        <property type="gene ID" value="CG723_19180"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003839">
        <property type="term" value="F:gamma-glutamylcyclotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06661">
        <property type="entry name" value="GGCT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017939">
        <property type="entry name" value="G-Glutamylcylcotransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013024">
        <property type="entry name" value="GGCT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036568">
        <property type="entry name" value="GGCT-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12935">
        <property type="entry name" value="PTHR12935"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110857">
        <property type="entry name" value="SSF110857"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN09869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="145" mass="16257" checksum="B9EA706E1C3F1A44" modified="2018-04-25" version="1">MSLYAAYASNLDARLMTRRAPHSPMRATGWLSGWRLTFGGEHMGWEGALATLVEAPRSQVFVALYDIAPMDEDSMDRWEGVGLDIYRRMRVRVDTLEGEEPAWVYVLNGYEGGFPSARYLGELADAAESAGAPHDYVMELRKHPC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JSY5</accession>
    <name>A0A2M9JSY5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Betaine-aldehyde dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CG723_19720</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CB01635</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000006">
        <property type="protein sequence ID" value="PJN09958.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN09958">
        <property type="protein sequence ID" value="PJN09958"/>
        <property type="gene ID" value="CG723_19720"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016620">
        <property type="term" value="F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016160">
        <property type="entry name" value="Ald_DH_CS_CYS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="SSF53720"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00070">
        <property type="entry name" value="ALDEHYDE_DEHYDR_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00687">
        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldedh" evidence="5">
        <location>
            <begin position="13"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="252"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PJN09958.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="500" mass="53326" checksum="C7538612073DBD56" modified="2018-04-25" version="1">MSENQSIFVDGEWRSAASGATREILDPADAQPFALIAEGGTQDADAAVAAARRAFDEGTWPATPVAERAALLRRVADLLVRDREKIGLLESRDAGKTVEEGRVDVDCVADAFRYFADLVVGEGGGRVVDAGSDEIHSVVVHEPVGVCSLITPWNYPLLQASWKVAPALAAGNTFVIKPSEITPLTTVVLIELLAEAGLPAGVANIVTGPGHTVGARLAEHPDVDLVSFTGGLISGTKVAQAAAADVKKIALELGGKNPNVVFADSCETDEGFDTAVDQALNAAFIHSGQVCSAGARLIVEESVRERFVAELARRAEKIRLGRGTEDGVECGPLVSAQQRNKTESYVASALAEGAVLRSGGKRPEPSEVRPADGYFYEPTVLDQCHREMRVVREEVFGPVLTVETFRTEDEAVALANDTEYGLAGAVWTADAGRARRVAGRLRHGTIWINDFHPYLPQAEWGGFGKSGIGRELGPAGLAEYRETKHVYQNLAPKPVRWFAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JT62</accession>
    <name>A0A2M9JT62_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">50S ribosomal protein L7/L12</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">rplL</name>
        <name evidence="7" type="ORF">CG723_20445</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CB01635</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Is thus essential for accurate translation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homodimer. Part of the ribosomal stalk of the 50S ribosomal subunit. Forms a multimeric L10(L12)X complex, where L10 forms an elongated spine to which 2 to 4 L12 dimers bind in a sequential fashion. Binds GTP-bound translation factors.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the bacterial ribosomal protein bL12 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000006">
        <property type="protein sequence ID" value="PJN10081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN10081">
        <property type="protein sequence ID" value="PJN10081"/>
        <property type="gene ID" value="CG723_20445"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00387">
        <property type="entry name" value="Ribosomal_L7_L12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.710">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00368">
        <property type="entry name" value="Ribosomal_L7_L12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000206">
        <property type="entry name" value="Ribosomal_L7/12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014719">
        <property type="entry name" value="Ribosomal_L7/12_C/ClpS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013823">
        <property type="entry name" value="Ribosomal_L7/L12_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008932">
        <property type="entry name" value="Ribosomal_L7/L12_oligo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036235">
        <property type="entry name" value="Ribosomal_L7/L12_oligo_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45987">
        <property type="entry name" value="PTHR45987"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00542">
        <property type="entry name" value="Ribosomal_L12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16320">
        <property type="entry name" value="Ribosomal_L12_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48300">
        <property type="entry name" value="SSF48300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54736">
        <property type="entry name" value="SSF54736"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00855">
        <property type="entry name" value="L12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 7" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Ribosomal_L12_N" evidence="6">
        <location>
            <begin position="6"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="domain" description="Ribosomal_L12" evidence="5">
        <location>
            <begin position="61"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF16320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PJN10081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="127" mass="13213" checksum="5E320A452D0FD9BB" modified="2018-04-25" version="1">MAKLSQDDLLAQFEEMTLIELSEFVKAFEEKFDVTAAAAVAVAGPAAGGPAAEAAEEQDEFDVILTGAGEKKIQVIKVVRELTSLGLKEAKDLVDGAPKPVLEKVAKDAAEKAAESLKGAGASVEVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-06-02" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JTY6</accession>
    <name>A0A2M9JTY6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_18450</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000005">
        <property type="protein sequence ID" value="PJN10356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN10356">
        <property type="protein sequence ID" value="PJN10356"/>
        <property type="gene ID" value="CG723_18450"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="39"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="50"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN10356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="64" mass="7021" checksum="4087E26D3FBD544C" modified="2018-04-25" version="1">MWAAQHEAPIYSRLIQERGDIPAQVRAVAEQTLRDLERVMPAPLPRAMPTQQTPALNSGGQGSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JU25</accession>
    <name>A0A2M9JU25_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CG723_18020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000005">
        <property type="protein sequence ID" value="PJN10287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN10287">
        <property type="protein sequence ID" value="PJN10287"/>
        <property type="gene ID" value="CG723_18020"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PJN10287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="129" mass="13894" checksum="9C889BD5D6210B9A" modified="2018-04-25" version="1">MSNPDELLVDIAVMVESGQSNQMSLTVVTSGAVITGRLAPEAVWRQRVSEVLTDSDHLGSFSEIFTADGKPDVRKRGEADDGPAPTHLHFHVARILQGSVGIPETGGMYRVAIQDVSAWTVGDFSYSDH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-06-02" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JU64</accession>
    <name>A0A2M9JU64_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_18950</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000005">
        <property type="protein sequence ID" value="PJN10436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN10436">
        <property type="protein sequence ID" value="PJN10436"/>
        <property type="gene ID" value="CG723_18950"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GFO_IDH_MocA" evidence="1">
        <location>
            <begin position="3"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN10436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="401" mass="43542" checksum="04971A8EB43ADD40" modified="2018-04-25" version="1">MTFSIGIVGAGQFSGQFAKLFRAHPGVGDIHVTDLLPERAEQLVAAERLTGTFPSFDAMLESDAVDAVAVFTQRWTHGPLVLKALRAGKHVYSAVPMAITEDEIAAIIDAVRDTGLTYMMGETSQYNPATVHARNQIADGAFGRLFYAEGDYVHDMDLGFYDAYRYSGGDDWKATASYPPLLYPTHSVGGVLGAWQTHAVSVSAIGVPDERGDGVFDKEVSQFGNDLSNATALFEVAGGGSFRTNEFRRVGYPSHIRESRFRFFGTDASMEQLATVSFWQDKKGVQDISELLQPKPTLPADDPSLQHIAPALRDAFTSGSAPVHDRARLPREFDHMPNGHEGSHHFLVDDFVTAVATRTLPSVNAWVAARYTLPGIVAHESALRGGARLDIPDFGDAPNSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JU75</accession>
    <name>A0A2M9JU75_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CG723_18985</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000005">
        <property type="protein sequence ID" value="PJN10441.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN10441">
        <property type="protein sequence ID" value="PJN10441"/>
        <property type="gene ID" value="CG723_18985"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PJN10441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="196" mass="21075" checksum="308F34E5871148DB" modified="2018-04-25" version="1">MGFLDILLGRTRPAPPDLDRLFGLPSAAVTLEAAAGFTPTGLGSVCFTTVEGTAFDTIRQDVGALLNADAERAVATEFSRDEYGYTWLLSQRAPSDLPALVGDLHAVNATLEGNGFGPQLLCSLAGFHNAEGHSLALVYLYKRGTFYPFAPLPGEKRDNALELRVRAVVGDDLRIEPDLERWFPVWGAPGLEGARS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JU99</accession>
    <name>A0A2M9JU99_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Sugar phosphate isomerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_19115</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000005">
        <property type="protein sequence ID" value="PJN10465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN10465">
        <property type="protein sequence ID" value="PJN10465"/>
        <property type="gene ID" value="CG723_19115"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036237">
        <property type="entry name" value="Xyl_isomerase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013022">
        <property type="entry name" value="Xyl_isomerase-like_TIM-brl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01261">
        <property type="entry name" value="AP_endonuc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51658">
        <property type="entry name" value="SSF51658"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AP_endonuc_2" evidence="1">
        <location>
            <begin position="30"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN10465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="291" mass="30842" checksum="927AEDA640CB98FB" modified="2018-04-25" version="1">MTAPAWKLGANPWIWHSPVTGHALADTLPRLAAWGFDCVELPMESAGDWDPGDAAKLLDATGLAPAAVIAVMPHGRELVDAAAATVRTTQDYLRHCVDAAHAIGAPVVAGPLYASVGRTWRMDRAAREAAYDELRTHLAPLVEHARAAGVRLAVEPLNRYETSLLNTVAQTLDALDGLPHDGIGVALDTYHQNIEEHSLPAAVGATGDRIAHVQVCANDRGTPGADHLDWSGFLDALREAGYQGPLCIESFTAHNDAIAVAASVWRPLAGSQDALATDGLRFLRAATGRSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JUB0</accession>
    <name>A0A2M9JUB0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CG723_19080</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CB01635</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000005">
        <property type="protein sequence ID" value="PJN10459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN10459">
        <property type="protein sequence ID" value="PJN10459"/>
        <property type="gene ID" value="CG723_19080"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="35"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="97"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="130"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="179"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="233"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="285"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="93"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PJN10459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="315" mass="35067" checksum="931A25227186BBFC" modified="2018-04-25" version="1">MSAPTLSKSSPAPARAPHQLPERRGSLARAVKRNLSAHGFLIGAVLCFSFFSWYPMVREFFLAFQKNKDGRTTWAGWSNLSYVFNDPAFWQAWRNTLLFTGLALVLGFAVPFLVAVLLNEFRHGQGYLRMLVYLPVMLPPVASVLLFKYFYDPGYGLFNRILGIFGIPDQQWLQSTSTAMVSVVIAATWMNMGGATLIYLAALQGIPGELYEAAELDGAGLWRKIWHVTIPQTRLILSLMFLMQIIATMQVFTEPFLLTNGAGPEGSTMTVVYLIYQYAFNFNNYGGAAALGLVLLVLLAGFSAVYVRLSRTQED</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-05-25" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JUB5</accession>
    <name>A0A2M9JUB5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Nitroreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_19050</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>a quinol + H(+) + oxidized coenzyme F420-(gamma-L-Glu)(n) = a quinone + reduced coenzyme F420-(gamma-L-Glu)(n)</text>
            <dbReference type="Rhea" id="RHEA:39663"/>
            <dbReference type="Rhea" id="RHEA-COMP:12939"/>
            <dbReference type="Rhea" id="RHEA-COMP:14378"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
            <dbReference type="ChEBI" id="CHEBI:133980"/>
            <dbReference type="ChEBI" id="CHEBI:139511"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the F420H(2)-dependent quinone reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000005">
        <property type="protein sequence ID" value="PJN10453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN10453">
        <property type="protein sequence ID" value="PJN10453"/>
        <property type="gene ID" value="CG723_19050"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004378">
        <property type="entry name" value="F420H2_quin_Rdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04075">
        <property type="entry name" value="F420H2_quin_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00026">
        <property type="entry name" value="hi_GC_TIGR00026"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00029371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN10453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="134" mass="15390" checksum="523FF6F8759416EE" modified="2018-04-25" version="1">MSRYREFKFRAVTSFQRRIGNPLLSRLPGQILLETTGRTSGLPRRTPVGGLLVGREFWWVSEYGDKSQYVRNIQADPKIRVRIKGRWHTGTAHLLPDDDARARLKRLPRYNSAAVRTLGTNLLTLRADLTDLTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-06-02" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JUL0</accession>
    <name>A0A2M9JUL0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_15190</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000004">
        <property type="protein sequence ID" value="PJN10564.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN10564">
        <property type="protein sequence ID" value="PJN10564"/>
        <property type="gene ID" value="CG723_15190"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="22"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN10564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="118" mass="12702" checksum="A65B179482D706DE" modified="2018-04-25" version="1">MVIGPAQGQQNLASSPARKRAAARAIENHIEPDTRHSGEWADEDTGAAVRAFDAKDGHGWVTSSSLKKAHKAWGEQVKSLMNRLSSEKVSLRATTALLQGTDFGVGAQVRTTSSLDRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JUU4</accession>
    <name>A0A2M9JUU4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CG723_15630</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000004">
        <property type="protein sequence ID" value="PJN10640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN10640">
        <property type="protein sequence ID" value="PJN10640"/>
        <property type="gene ID" value="CG723_15630"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021994">
        <property type="entry name" value="DUF3592"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12158">
        <property type="entry name" value="DUF3592"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PJN10640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="149" mass="15914" checksum="D6282B95726BC1B2" modified="2018-04-25" version="1">MGPLWLLALIPFIAGLALAVSQVLQLVTETLRRSTGTVVDATVTGHVASNEASYAVLHPVVSWTAPDGTAHEQALPDEVGAHALPEGRRVRVRFDPAHPALAALDTDGRYRSCVAWLWAGTVLWAGTLAVVVGRMAYVWNESDGYASGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JUW2</accession>
    <name>A0A2M9JUW2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CG723_15215</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CB01635</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000004">
        <property type="protein sequence ID" value="PJN10567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN10567">
        <property type="protein sequence ID" value="PJN10567"/>
        <property type="gene ID" value="CG723_15215"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="50"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="80"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="114"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="142"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="171"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="201"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="242"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="265"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="298"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="327"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="361"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="388"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="434"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="472"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="7">
        <location>
            <begin position="48"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PJN10567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="508" mass="51192" checksum="5F75A60FE026B1C8" modified="2018-04-25" version="1">MAALEPRDDADVVATSTPPPTAPTTPTAPTTPTTAPGVGVLGRSYRSLSVGIVSVVLLIAFEATAVGTAMPVAARELDGVSLYAFAFSGYFTTSLFGMVFSGQWADRRGPLGPLGAGIAAFAVGLLLAGTAGSMWMFIAGRAVQGLGGGLVIVALYVVVSRAYPERLRPAIMAAFAASWVVPSVVGPLASGAVTEHLGWRWVFIGIPVLVVFPLALALPQIRRRASGPAEGAARGAVDGRRIRLALGISLGAGLLQYAAQDLRWISLLPGAVGVALLVPAVLGLLPRGTYRAARGLPAVVLLRGVAAGSFIAAESFVPLMLVTQRGLSPMMAGLSLAVGGATWAVGSFLQSRPRFEPYRERLMAGGMVLVAAAVATAPSVLIEAVPVWIVAVAWGFGCLGMGLVISSTSVLLLELSAPEEAGANSAALQISDGLSNVVLLAVGGAAFAALGGGAVGSAHEVASAGGGGSHPAAFVAVFLPMAAVALVGAWVATRVRSASRPAASGLLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JV17</accession>
    <name>A0A2M9JV17_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5">D-ribose pyranase</fullName>
            <ecNumber evidence="2 5">5.4.99.62</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">rbsD</name>
        <name evidence="6" type="ORF">CG723_16190</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CB01635</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the interconversion of beta-pyran and beta-furan forms of D-ribose.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 5">
            <text>beta-D-ribopyranose = beta-D-ribofuranose</text>
            <dbReference type="Rhea" id="RHEA:25432"/>
            <dbReference type="ChEBI" id="CHEBI:27476"/>
            <dbReference type="ChEBI" id="CHEBI:47002"/>
            <dbReference type="EC" id="5.4.99.62"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="5">Carbohydrate metabolism; D-ribose degradation; D-ribose 5-phosphate from beta-D-ribopyranose: step 1/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homodecamer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the RbsD / FucU family. RbsD subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.4.99.62" evidence="2 5"/>
    <dbReference type="EMBL" id="NNBL01000004">
        <property type="protein sequence ID" value="PJN10731.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN10731">
        <property type="protein sequence ID" value="PJN10731"/>
        <property type="gene ID" value="CG723_16190"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00916">
        <property type="reaction ID" value="UER00888"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0062193">
        <property type="term" value="F:D-ribose pyranase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016872">
        <property type="term" value="F:intramolecular lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048029">
        <property type="term" value="F:monosaccharide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019303">
        <property type="term" value="P:D-ribose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1650.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01661">
        <property type="entry name" value="D_rib_pyranase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023064">
        <property type="entry name" value="D-ribose_pyranase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023750">
        <property type="entry name" value="RbsD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007721">
        <property type="entry name" value="RbsD_FucU"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37831">
        <property type="entry name" value="PTHR37831"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05025">
        <property type="entry name" value="RbsD_FucU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102546">
        <property type="entry name" value="SSF102546"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="3 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 5" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="5">
        <location>
            <begin position="118"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="5">
        <location>
            <position position="20"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="28"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="96"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PJN10731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="129" mass="13331" checksum="D2F7918EFA85C925" modified="2018-04-25" version="1">MRKAGILNRHLAGALAELGHGDGVLVCDAGMPIPAGPRVVDLAFRAGVPSFAEVLGGLLDELVVEGGTAAAEIRAANPGAAGLLAERLPALAFVPHEELKELSRGARLVVRTGEARPYANVLLRCGVFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JV25</accession>
    <name>A0A2M9JV25_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Aminopeptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_16125</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000004">
        <property type="protein sequence ID" value="PJN10719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="ESTHER" id="bacfn-q5lhv2">
        <property type="family name" value="Peptidase_S37"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN10719">
        <property type="protein sequence ID" value="PJN10719"/>
        <property type="gene ID" value="CG723_16125"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008761">
        <property type="entry name" value="Peptidase_S37"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05576">
        <property type="entry name" value="Peptidase_S37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014721795" evidence="1">
        <location>
            <begin position="24"/>
            <end position="475"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN10719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="475" mass="53027" checksum="40D091F4472FAA4B" modified="2018-04-25" version="1">MRNALRWLLALVVLIGTVSTATAATAAQARPAASDTSTDIKDRLLAVPGMSLVEEKPYTGYRYFVLNYTQPVDHRHPSKGTFQQRITVLHKDVSRPTVMFTSGYNVSTTPSRSEPTRIVDGNQISVEYRYFTPSRPAPADWSKLDIWQAASDQHGIYQALKPIYGKNWLTTGGSKGGMTATYYERFYPRDMDGVVAYVAPNDVVNKEDSAYDDFFKTVGPKDCRVALQNVQRETLVRRDALEKKYADYLKANNYTVDTVGSLDKAYEATVLDLVWGFWQYQPSQTACAEVPDAATVTDQALFDYVDAVGGWSSYADQGLTQYTPYYYQAGTQLGSPDIKQPWLGNLSRYGYQPPRNFVPRSIPMKFQPSAMRDVDSWVRHHATRMLYVYGSNDPWGAERFRPGKGSTDSYVLTAPGANHGANVAGLNADDKTFATERILKWAGVSAPAAQAAKPLATYDARLDKRDVQRELTLRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JV85</accession>
    <name>A0A2M9JV85_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Sugar ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CG723_16500</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CB01635</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000004">
        <property type="protein sequence ID" value="PJN10779.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN10779">
        <property type="protein sequence ID" value="PJN10779"/>
        <property type="gene ID" value="CG723_16500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="21"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="76"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="111"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="163"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="206"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="278"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="73"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PJN10779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="311" mass="34197" checksum="CFB31CAD04A69328" modified="2018-04-25" version="1">MALTLSNPARRRLRTLGFLSPWLIGFSVFFAYPLIATVYFSFMHYNQIQKPDFVGLRNWKYVFEQMPLFGPALWNTLWLVVVMVALRVVFGLSLGLLITKIKTGAGFFRTAFYLPYLAPPVAATVAFVFLLNPSTGPVNEVLAHLGITGPNWFNDAAWAKPSLVMLSLWGIGDLMVIFMAALLDVPREQYEAAELDGAGAWSKFRYVTWPSITPIVMFAVVTGVVQTMQYYTQALVAGKIASGVSIGPGSVIQPGYPDHSTLTVPQLVYSMGFQNFNTGAACVLSLVLFAIAMAVTMLLMRKRSGLLAAED</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JWC0</accession>
    <name>A0A2M9JWC0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Aminotransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_09330</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN11149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN11149">
        <property type="protein sequence ID" value="PJN11149"/>
        <property type="gene ID" value="CG723_09330"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044249">
        <property type="term" value="P:cellular biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000192">
        <property type="entry name" value="Aminotrans_V_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00266">
        <property type="entry name" value="Aminotran_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotran_5" evidence="1">
        <location>
            <begin position="36"/>
            <end position="371"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN11149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="385" mass="41547" checksum="A683CD69717D47C1" modified="2018-04-25" version="1">MSIAPLDAAERFRARFPSLKDTVHLASCSQGAASEHVLTALQEFQWSMRSQGAPWGEWMAQVDAARATFAARIGAQPDEIAVVGCASEGAYQVASTLDWSRRPGLVTTDMEFPSIAHVWLAQERRGARVRHVPEQGGTVPAEDYAAAIDDTTNLVSVPLVSYRNGARLPVTDTVRAAHAVGARVFIDAYQGLGVLPVDVRELDCDYLVCGALKYLLGVPGIAFLYVRGGLRDDMDPQLTGWFGRVDPFAFDPRSLDFPDTARRFETGTPSIPSAYAAAAGLRTLADVDPKDIEAHIGALTTYAHARLTEIGETPASPADPELRGPQMAIADPAPDALAAALAERRIVTSPRGTLLRLSFHYYNNTSDVDALIDALGEIRAQQHIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JWE7</accession>
    <name>A0A2M9JWE7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CG723_09530</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CB01635</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN11179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN11179">
        <property type="protein sequence ID" value="PJN11179"/>
        <property type="gene ID" value="CG723_09530"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015658">
        <property type="term" value="F:branched-chain amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06581">
        <property type="entry name" value="TM_PBP1_LivM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001851">
        <property type="entry name" value="ABC_transp_permease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043428">
        <property type="entry name" value="LivM-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30482">
        <property type="entry name" value="PTHR30482"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02653">
        <property type="entry name" value="BPD_transp_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="40"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="65"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="98"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="143"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="247"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="276"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="315"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="339"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="364"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="389"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="416"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="460"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="501"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="539"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="564"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="606"/>
            <end position="663"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PJN11179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="663" mass="68001" checksum="9CDC65F404355E44" modified="2018-04-25" version="1">MRGVCGMSDLLPFLVVGITTGSVYGLAAMGLVLTYKTSGIFNFAHGAIAAVSAFVYYDLRTLRGLPWPLALAVAVIVVPPLIALLMERVTRSLAAGTAATKIVATVGLQLVIMSALLAGYGGAALDFPGFLPTDTVTVIGVNVGIDQLTSAIVAAVCALGFFAFFRLSSMGVRMRAVVDDPDLLELSGTSAFAVRSRAWLIGCWFAAASGVLLAPQLGLDVLLLTLLVVQAYGAAAVGLFSSLPLTYAGGLLIGILAALATKWVSHSETFSGLPPAMPFVVLFVALLLVGRGRLTEIGGHRPAPASRPLVSRATARILAVAAVVLAAGIPIVAESKLPVYSAALVFVLIFASLQLLVRTSGQVSLAHAALVAVGASTFSHLAVGAGLPWLIAVLLAGAAAVPVGMLVAIPAIRLSGLYLALATFGLGLLLERAVYGTSWMFGATNTLPAPRPGLFETDAAFYYVLLAFAVAGSLLIALVGRSRLGRLLRAMADSPTTLSTLGLGVNVTRVTVFAISAFVAGVAGALYAAQGQSATGAPFLSYTSLTWLTVLVLCAGLRSAGPPLAAVLVAVVPAYLTNGTFAQALPVLFGFGALLVALYEAGAARRRGTGQPPEEPAGSRSDERLDAPGPAAQRLTAARKARRAQARPARVRVGAGLTKEVAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JWM0</accession>
    <name>A0A2M9JWM0_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 7">L-carnitine dehydrogenase</fullName>
            <shortName evidence="7">CDH</shortName>
            <shortName evidence="7">L-CDH</shortName>
            <ecNumber evidence="5 7">1.1.1.108</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">lcdH</name>
        <name evidence="10" type="ORF">CG723_09755</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CB01635</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the NAD(+)-dependent oxidation of L-carnitine to 3-dehydrocarnitine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>carnitine + NAD(+) = 3-dehydrocarnitine + H(+) + NADH</text>
            <dbReference type="Rhea" id="RHEA:19265"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17126"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57885"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.108"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 7">Amine and polyamine metabolism; carnitine metabolism.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4 7">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the 3-hydroxyacyl-CoA dehydrogenase family. L-carnitine dehydrogenase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.108" evidence="5 7"/>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN11218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN11218">
        <property type="protein sequence ID" value="PJN11218"/>
        <property type="gene ID" value="CG723_09755"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00117"/>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047728">
        <property type="term" value="F:carnitine 3-dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070403">
        <property type="term" value="F:NAD+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042413">
        <property type="term" value="P:carnitine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02129">
        <property type="entry name" value="L_carnitine_dehydrog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006176">
        <property type="entry name" value="3-OHacyl-CoA_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006108">
        <property type="entry name" value="3HC_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026578">
        <property type="entry name" value="L-carnitine_dehydrogenase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00725">
        <property type="entry name" value="3HCDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02737">
        <property type="entry name" value="3HCDH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="SSF48179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0520">NAD</keyword>
    <keyword evidence="7 10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="3HCDH_N" evidence="9">
        <location>
            <begin position="12"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="domain" description="3HCDH" evidence="8">
        <location>
            <begin position="190"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="16"/>
            <end position="21"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004855"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00021240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PJN11218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="322" mass="34261" checksum="191B211E7EB20D08" modified="2018-04-25" version="1">MTSTEPENVRRVACVGAGVIGGGWVAHFLARGYDVTAWDPAPDAELRLRRLVDAAWPALTQLGLADGASTDRLTVTATLEEAVADTEFVQESAPEKLDLKRDLLARLDAATPPGVVIASSTSGYPMTDMQTDAEGAGRLVVGHPFNPPYLIPLVEVVGGERTSAEAVAWASRFYEVAGKSVITMDREVPGFIANRLQEALWREALHMVANGEATVKEIDDSITEGPGLRWAFMGPMLTFALAGGEGGMAHMLDHFGPSLKSPWTRLEAPELDKALYDSVVAGCDDAAAGRTIADLVAERDQGVIDVLRATGRLPGARKEAGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JWW5</accession>
    <name>A0A2M9JWW5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">L-rhamnose isomerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">rhaI</name>
        <name evidence="2" type="ORF">CG723_10650</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN11374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN11374">
        <property type="protein sequence ID" value="PJN11374"/>
        <property type="gene ID" value="CG723_10650"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013457">
        <property type="entry name" value="Rhamnose_iso-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036237">
        <property type="entry name" value="Xyl_isomerase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013022">
        <property type="entry name" value="Xyl_isomerase-like_TIM-brl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01261">
        <property type="entry name" value="AP_endonuc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51658">
        <property type="entry name" value="SSF51658"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02635">
        <property type="entry name" value="RhaI_grampos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AP_endonuc_2" evidence="1">
        <location>
            <begin position="76"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN11374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="399" mass="43796" checksum="59D128CF9DE75642" modified="2018-04-25" version="1">MTGSTAHEARTAAAKAVLKRQSIETPSWAYGNSGTRFKVFAQAGVPRTPREKLDDAAQVHAFTGAAPTVALHIPWDRVEGGPEGYAKLAAYAEERGVKLGAVNSNVFQDDDYKLGSVTNPDPAVRRKAVGHLLECVDIMDATGSRDLKLWFSDGTNYPGQDDLRDRQDRLEEALRTVYERLGDDQRMVLEYKLFEPAFYATDVPDWGTSYAHCLKLGEKAQVCVDTGHHAPGTNIEFIVAFLLREGRLGAFDFNSRFYADDDLMVGAADPFQLFRILYEVRRGGGLDADSGIAFMLDQCHNIEAKIPAIIRSVMNVQEATAKALLIDTEALAAAQREGDVLAANGVLMDAYNTDVRPLLGEVREELGLDPDPMAAYRRSGWQERIVKDRVGGVQAGWGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JWX1</accession>
    <name>A0A2M9JWX1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DNA-binding response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CG723_10290</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN11312.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN11312">
        <property type="protein sequence ID" value="PJN11312"/>
        <property type="gene ID" value="CG723_10290"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007492">
        <property type="entry name" value="LytTR_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04397">
        <property type="entry name" value="LytTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00850">
        <property type="entry name" value="LytTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50930">
        <property type="entry name" value="HTH_LYTTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="2">
        <location>
            <begin position="3"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="domain" description="HTH LytTR-type" evidence="3">
        <location>
            <begin position="143"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PJN11312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="249" mass="27160" checksum="F98D562144E48D35" modified="2018-04-25" version="1">MLRVLAVDDEEPALAELLYLLRADPRVRAAEGATDANEALRRIGRALDAGGDDAGAIDVLFLDIQMAGLTGLDVARLLAGFAKPPLIVFVTAHEDFAVQAFDLKAVDYVLKPVRRERLAEAVRRVAEQAAVARPAVDLSADRIPVELGGVTRLVAVADITYAEAQGDYARLHTADASHLVRIPLTTLEERWQPHGFVRIHRSHLVALHRIDELRLDGGGMSVRIGDAELAVSRRHASRVRELLMRRAGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JX61</accession>
    <name>A0A2M9JX61_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">LysR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_10870</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LysR transcriptional regulatory family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN11412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN11412">
        <property type="protein sequence ID" value="PJN11412"/>
        <property type="gene ID" value="CG723_10870"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005119">
        <property type="entry name" value="LysR_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000847">
        <property type="entry name" value="Tscrpt_reg_HTH_LysR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00126">
        <property type="entry name" value="HTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03466">
        <property type="entry name" value="LysR_substrate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00039">
        <property type="entry name" value="HTHLYSR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50931">
        <property type="entry name" value="HTH_LYSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH lysR-type" evidence="2">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN11412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="309" mass="33890" checksum="9A83DD8296E54B6A" modified="2018-04-25" version="1">MLFRQLEYLVALSRERHFARAAQACYVSQPALSEAIRKLEDELDVPLVRRGRKYEGLTPEGERIVVWAQRILADRDALKDEVGALRTGLSGRMRIGSVPTASGAVSLLTGPFCAEHPLVTVEVIADLQSRDILRQLQNFEIDAGITYLHKDLAENFNTVPLYEERYVLLITAADALAHRTTATWTEASRLPLCLLTDSMQGRRVLDEVFAEAGTRPSPRVETDSVGALFAHVRTGRWASIVPHAWLHVFGVPHGMRAVPLVEPSRTVPVGLVVTAREPGSVMARALTDVARHTDVAAALERLPGGPGVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JX68</accession>
    <name>A0A2M9JX68_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Peptidase M28</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CG723_11310</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CB01635</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="1">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN11484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN11484">
        <property type="protein sequence ID" value="PJN11484"/>
        <property type="gene ID" value="CG723_11310"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032610">
        <property type="entry name" value="DUF2172"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032589">
        <property type="entry name" value="DUF4910"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012353">
        <property type="entry name" value="UCP015244"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032622">
        <property type="entry name" value="UCP01524_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09940">
        <property type="entry name" value="DUF2172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16254">
        <property type="entry name" value="DUF4910"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16221">
        <property type="entry name" value="HTH_47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015244">
        <property type="entry name" value="UCP015244"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="DUF4910" evidence="4">
        <location>
            <begin position="12"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="domain" description="DUF2172" evidence="2">
        <location>
            <begin position="62"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="domain" description="HTH_47" evidence="3">
        <location>
            <begin position="351"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="182"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="188"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="318"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR015244-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF16221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF16254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PJN11484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="427" mass="47021" checksum="0C682E8A10EE5A03" modified="2018-04-25" version="1">MAPMTAVGEEMHALVERLYPLCRSITGDGVRATLDVVGEYVPLQVHEVPTGTQVLDWTVPQEWNIRDAYIADTAGNRVVDFAASSLHVLGYSLPVSATMPLAELREHLHTLPDHPAWVPYRTSYYQPTWGFCLAQETLDALPDGEYEVRIDSTLADGHLTYAEHVIPGQVPDEVIVSCHVCHPSLANDNLAGIAVATYLARALAGQRPYYTYRFIYAPGTIGAITWLARNKERIDRVKHGLVLACAGDSGQLTYKQSRRGDAEIDRVLRHVLAASERPYHVSEFTPYGYDERQFCSPGFDLGVGSLSRTPYAGYPEYHTSADNPDFVSPEAMADTLAVCREAFAVLDRNRRYLNLSPYGEPQLGRRGLYDSLGGRSDAKQAQMAMLWVLSLSDGEHSLLDVAERSELPFDTVAVAADALHGAGLIKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JY08</accession>
    <name>A0A2M9JY08_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_12830</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN11738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN11738">
        <property type="protein sequence ID" value="PJN11738"/>
        <property type="gene ID" value="CG723_12830"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045756">
        <property type="entry name" value="DUF6183"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19681">
        <property type="entry name" value="DUF6183"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="167"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN11738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="365" mass="40191" checksum="2F9B8245A52117D3" modified="2018-04-25" version="1">MDDFGPLDWDQVEQRAARGDTSYLRELAARLAERREAAAEQAREYGCHLAHVVRVLALTPGRDSLTQLLLLLDEKQASTSLHPRFVASLLAEHQEPADLAATVFDRPHSDRLDELRGCLFHELILRGVDIDDFRPLRTWAIVRPGWSALAWLPDQLRDMETAVDFPSRSLRGSARGGGSGLPTEGRMDPPTPRVTARSALQDVATTDVYESIVAAPEAGEWGDHGAWVFRLDEAIAPEQVPALLPTLPMPCVDGLGPTGRFEIAIRPVDEIWRLLFATASMGGMYSTGVDGAYGRLWAWRSLAGLSGTAADASADEVERHASQSTWFHFEADVEWFHNDLCADYGIATLSPDRRRLAVLAATDTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JY39</accession>
    <name>A0A2M9JY39_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Proline hydroxylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_13190</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN11796.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN11796">
        <property type="protein sequence ID" value="PJN11796"/>
        <property type="gene ID" value="CG723_13190"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018655">
        <property type="entry name" value="DUF2086"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09859">
        <property type="entry name" value="Oxygenase-NA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN11796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="265" mass="29747" checksum="A424DFC7FE36954F" modified="2018-04-25" version="1">MNQPHQRTPAPDTLFSDHAPAAGAPPRIPYDPTVPALSELNWADLYGRLNDEGVAVTPPLLSRTQCQEIIDTFGEPALFRSTVVMQRYQFGRGTYKYYADPTAVPLVQTLRERLYPPMAWMANQWAPQLGERAFPGTLDELIDECGGNGQKRPTPLILQYGQGDYACLHQDIYGDIVFPLQIAVMLNQPGEDFTGGENVFVEQRPRFQSRAMVVKPQLGQGMIFPVRHRPVRGTNGFRRHPMRHGTNAVESGHRNTLGLIFHNAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JY62</accession>
    <name>A0A2M9JY62_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Peptide ABC transporter substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CG723_13270</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN11810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN11810">
        <property type="protein sequence ID" value="PJN11810"/>
        <property type="gene ID" value="CG723_13270"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015833">
        <property type="term" value="P:peptide transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013563">
        <property type="entry name" value="Oligopep_ABC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08352">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01727">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="5"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="48"/>
            <end position="55"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PJN11810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="334" mass="36403" checksum="2D010F727A6B46C5" modified="2018-04-25" version="1">MTPLLEVTDLTKHFPIRSRAFRPGGGAIKAVDGVSFSVDAGQTLGLVGESGCGKSTTGRLLMRLLEPTSGSIRLDGREIAELRRSELQEYRRRVQMVFQNPSSSLNPRQSVGSAIAAPLLAQRITPAGGVKAKVRDLMDRVGLRPDHYNRFPHEFSGGQKQRVGIARALALDPQLIICDEPVSALDVSVQAQVINLLEDIQRDTGVAYLFIAHDLSVVQHFADRIAVMYLGKIMEYGDTSRVFGAPEHPYTRALLSAVPQPDPAADRSGRIRLKGDLPSPADPPRGCVFQSRCPVHTQLDPERRQLCTESVPSGDIACHHTEVTAETLATTTSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JY98</accession>
    <name>A0A2M9JY98_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CG723_13515</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN11850.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN11850">
        <property type="protein sequence ID" value="PJN11850"/>
        <property type="gene ID" value="CG723_13515"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.660">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009499">
        <property type="entry name" value="DUF1116"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024033">
        <property type="entry name" value="Uncharacterised_dom_sf_YlbE"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06545">
        <property type="entry name" value="DUF1116"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PJN11850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="477" mass="49774" checksum="40CE6B0F6A958B35" modified="2018-04-25" version="1">MSTQATSLFNSDLSVINVGLAMFDRDITAQGAQVSTLDWTPPGGGSPEVLAALDALEDPRVAERTEAANAEAVDRIIGARPMLVGFGRAIDVVPGMTPTTILHAGPPITWDRMAGAMKGAVTGALVFEGLARDLYAAERLAASGEITFSPCHEHDCVGSMAGVTSASMYMHIVRNETHGNTAFTNLSEQMAKILRMGANDESVVERLVWMRDVLGPMLKEAMEIGGPVDLRLLLSQALHMGDECHNRNIAGTLLLAQALTPALLQTSFTTEQKKEVFDFIASSDYFSGPTWLAMAKAAMDAAHGIEGSTIVTTMARNGVEFGLRVSGLPGNQWLTGPAQPVVGPMFAGFKPEDAGLDIGDSAISETYGFGGFAMATAPAIVALVGGTVQEAVAFTRDMGEITTTENPNVTIPALGFQGIPTGIDVRKVLATGILPVINTAIAHKEAGIGMIGAGITHPPAAVFEQAATALALSSTVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JYV7</accession>
    <name>A0A2M9JYV7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_14700</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN12049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN12049">
        <property type="protein sequence ID" value="PJN12049"/>
        <property type="gene ID" value="CG723_14700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GFO_IDH_MocA" evidence="1">
        <location>
            <begin position="8"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN12049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="392" mass="41943" checksum="5884694A620BCF2D" modified="2018-04-25" version="1">MTAQPVAVVLVGGRGFGRIHRANLRRLTGQGQVQVVGVCDQSPLDAEELDGLGPFASISQSTDLKALLERTRPAVTIISTPLHTHVPLALTAVRAGSHVLLEKPPASSLAGFQQLAEELDRSGRVCQVGFQSFGSAAVASVRQLIADGAIGRPVGIGAAGAWVREARYYARSPWAGRRRVAVGPGAQDMVDVVDGVLTNPLAHALATALRVDGSDRQDDVAGVELELYRAHDIEADDTSCVRVTTAHDTTITLAATLCAEQNVAPYIVVHGEQGRITLHYTEDRVLLERRGQVSQEYEHPRTDLLENLIAHLRDGDELLSPLERSGAFTRVLEAVRIAPEPVRLPPGVWHMLGEGAEQRRVIPGIDALTASSAGRLALFSELDAPWAKATEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JYX5</accession>
    <name>A0A2M9JYX5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CG723_14820</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN12066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN12066">
        <property type="protein sequence ID" value="PJN12066"/>
        <property type="gene ID" value="CG723_14820"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PJN12066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="76" mass="7949" checksum="8D257D4A90F63D30" modified="2018-04-25" version="1">MTSSPATMRAVRLSAPGTMDNLRLTTIPLPPERDGWVWCVPPTTPTHHDLQSAERAPVGVRADSGGALEAVTEGGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JZ84</accession>
    <name>A0A2M9JZ84_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Bifunctional protein FolD</fullName>
        </recommendedName>
        <domain>
            <recommendedName>
                <fullName evidence="8">Methylenetetrahydrofolate dehydrogenase</fullName>
                <ecNumber evidence="8">1.5.1.5</ecNumber>
            </recommendedName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="8">Methenyltetrahydrofolate cyclohydrolase</fullName>
                <ecNumber evidence="8">3.5.4.9</ecNumber>
            </recommendedName>
        </domain>
    </protein>
    <gene>
        <name evidence="8" type="primary">folD</name>
        <name evidence="11" type="ORF">CG723_12720</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CB01635</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + NADP(+) = 5,10-methenyltetrahydrofolate + NADPH</text>
            <dbReference type="Rhea" id="RHEA:22812"/>
            <dbReference type="ChEBI" id="CHEBI:15636"/>
            <dbReference type="ChEBI" id="CHEBI:57455"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.5.1.5"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>5,10-methenyltetrahydrofolate + H2O = (6S)-10-formyltetrahydrofolate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23700"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57454"/>
            <dbReference type="ChEBI" id="CHEBI:57455"/>
            <dbReference type="EC" id="3.5.4.9"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="8">One-carbon metabolism; tetrahydrofolate interconversion.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.5.1.5" evidence="8"/>
    <dbReference type="EC" id="3.5.4.9" evidence="8"/>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN12192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN12192">
        <property type="protein sequence ID" value="PJN12192"/>
        <property type="gene ID" value="CG723_12720"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00193"/>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004477">
        <property type="term" value="F:methenyltetrahydrofolate cyclohydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004488">
        <property type="term" value="F:methylenetetrahydrofolate dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009086">
        <property type="term" value="P:methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006164">
        <property type="term" value="P:purine nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035999">
        <property type="term" value="P:tetrahydrofolate interconversion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01080">
        <property type="entry name" value="NAD_bind_m-THF_DH_Cyclohyd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01576">
        <property type="entry name" value="THF_DHG_CYH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046346">
        <property type="entry name" value="Aminiacid_DH-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000672">
        <property type="entry name" value="THF_DH/CycHdrlase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020630">
        <property type="entry name" value="THF_DH/CycHdrlase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020867">
        <property type="entry name" value="THF_DH/CycHdrlase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020631">
        <property type="entry name" value="THF_DH/CycHdrlase_NAD-bd_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00763">
        <property type="entry name" value="THF_DHG_CYH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02882">
        <property type="entry name" value="THF_DHG_CYH_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00085">
        <property type="entry name" value="THFDHDRGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53223">
        <property type="entry name" value="SSF53223"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00767">
        <property type="entry name" value="THF_DHG_CYH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0368">Histidine biosynthesis</keyword>
    <keyword evidence="3 8 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 8" id="KW-0486">Methionine biosynthesis</keyword>
    <keyword evidence="7 8" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="4 8" id="KW-0521">NADP</keyword>
    <keyword evidence="1 8" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="5 8 11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2 8" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="THF_DHG_CYH" evidence="9">
        <location>
            <begin position="10"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="domain" description="THF_DHG_CYH_C" evidence="10">
        <location>
            <begin position="130"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="170"/>
            <end position="172"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="195"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PJN12192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="292" mass="30556" checksum="353FCED199B82335" modified="2018-04-25" version="1">MSPTHTAHRMDGTGTARRLVEESAGRAAELVRRTGSAPCLATVLVGEDPASVTYVRMKQARCAKAGIESRRVQLPAETTTAELVAALRTLSQDASVHGILLQHPVGPHIDERAAFEAIAPEKDVDGVTMTSFGAMAFGLPGFVSCTPGGIMRLLDEYDVDVTGRHAVVVGRSAILGKPAGMLLLARDATVTYCHSRTADLSAYVREADIVVAAVGRPRLIRGEDIKPGAVVIDAGYNAGNVGDVDFDTAAERARLITPVPGGVGPMTIAVLLAQTVTAAYHQLGADLDRALA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JZB2</accession>
    <name>A0A2M9JZB2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CG723_08680</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN12097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN12097">
        <property type="protein sequence ID" value="PJN12097"/>
        <property type="gene ID" value="CG723_08680"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PJN12097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="86" mass="9189" checksum="468AC61E9B107FEF" modified="2018-04-25" version="1">MLVVQGVSATAVVRDRTGEPVVLLSGELPEALTPAALDELLNLAAAVLDAEELRLFRSCLSALHCGEKLDERRIEVSGAVLTVYRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-09-29" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JZF4</accession>
    <name>A0A2M9JZF4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CG723_04055</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CB01635</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000002">
        <property type="protein sequence ID" value="PJN12246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN12246">
        <property type="protein sequence ID" value="PJN12246"/>
        <property type="gene ID" value="CG723_04055"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="26"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="62"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="94"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="152"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="183"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="246"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="292"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="319"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="353"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="385"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="428"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="454"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="28"/>
            <end position="478"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PJN12246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="480" mass="49132" checksum="E7B939517B988ABA" modified="2018-04-25" version="1">MTGTGTRSLSVATTARSATAPPALGGLGLFTVLVGAALPLIDFFIVNVALPTIGHDLAAGEALLELVVAGYGLAYAVLLVLGGRLGDLFGRRRLFLGGMIAFGLTSLACGLAPDAWTLVAARVAQGAASAAMLPQVLATIQSTTTGRRRAKAMGLYGATAGLSMVAGQILGGVLIAADVFGTGWRSVFLVNVPVVLVGLFLAARAVPETRSEHPEPVDGPGTVLLAASLLTLLAPLTEGRAAGWPLWTWLSLAVFPFIAYAFYQVERRADRHGRTPLVPPSLFALVSLRRGLIMVVPFSIGFSGFMFVIAVALQQGEHLGPVPAGLALAPMAVAFFAVSLAGPRLIARYGTRIVTAGGIIQGAGVVLIALAAWRTWPDLGVLELMPGAALAGAGQALQLPILFRLILSEVPASRAGVGSGVMITTQQSALALGVATLGSLFLALIPSLGARDALVTTLLAQLAGIALTTALSVRLPRVVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-06-02" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JZN2</accession>
    <name>A0A2M9JZN2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_04325</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000002">
        <property type="protein sequence ID" value="PJN12290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN12290">
        <property type="protein sequence ID" value="PJN12290"/>
        <property type="gene ID" value="CG723_04325"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005651">
        <property type="entry name" value="Trm112-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03966">
        <property type="entry name" value="Trm112p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="52"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="61"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN12290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="76" mass="8604" checksum="D269DE57111CF44D" modified="2018-04-25" version="1">MKPDDPLLRILACPLDKGPLHLLPPEEDALLSGEALYNPRLRRRYPIVDGIPQLLPSSGEQVPEDEHERLLDRMSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K027</accession>
    <name>A0A2M9K027_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_05315</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000002">
        <property type="protein sequence ID" value="PJN12458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN12458">
        <property type="protein sequence ID" value="PJN12458"/>
        <property type="gene ID" value="CG723_05315"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="43"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="46"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN12458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="77" mass="9100" checksum="5940D385C07884A0" modified="2018-04-25" version="1">MALFKRRTVGKPGEWYYCLEHQKVEEGPDCPNKDRFGPYASRTEAEHAMETARERNLEWETDPKWHDATAKDEDDKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K0B2</accession>
    <name>A0A2M9K0B2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CG723_05865</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000002">
        <property type="protein sequence ID" value="PJN12558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN12558">
        <property type="protein sequence ID" value="PJN12558"/>
        <property type="gene ID" value="CG723_05865"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PJN12558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="70" mass="7385" checksum="1B366CB8128E0E71" modified="2018-04-25" version="1">MTNLKVRTASAPLDLEGGLASLRGDCARMAPHWTAPAKEKQTPVAPSLPHGVVVPSKSARLIDSMSEYGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K0E0</accession>
    <name>A0A2M9K0E0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Phenazine-specific anthranilate synthase component I</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_06050</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000002">
        <property type="protein sequence ID" value="PJN12592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN12592">
        <property type="protein sequence ID" value="PJN12592"/>
        <property type="gene ID" value="CG723_06050"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044249">
        <property type="term" value="P:cellular biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071704">
        <property type="term" value="P:organic substance metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="CDD" id="cd01743">
        <property type="entry name" value="GATase1_Anthranilate_Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005801">
        <property type="entry name" value="ADC_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019999">
        <property type="entry name" value="Anth_synth_I-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015890">
        <property type="entry name" value="Chorismate_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017926">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006221">
        <property type="entry name" value="TrpG/PapA_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11236">
        <property type="entry name" value="PTHR11236"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00425">
        <property type="entry name" value="Chorismate_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00117">
        <property type="entry name" value="GATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56322">
        <property type="entry name" value="SSF56322"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Chorismate_bind" evidence="2">
        <location>
            <begin position="109"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="domain" description="GATase" evidence="1">
        <location>
            <begin position="435"/>
            <end position="618"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN12592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="638" mass="68360" checksum="57AD88D664E88ED2" modified="2018-04-25" version="1">MDLSELLHDDRPFALLRRRAPGRAAGNTDTVELLIGPVSTYERLADIPEGLALVPFRQIRERGFDVRDDGTPLAVLTPEETHELPLADVLAQLPAHDVRVSDGGFDVDDAAYADIVERVLREEIGQGEGANFVIRRTYEGEIRGFGRADALALFRRLLAGERGAYWTFVVHTGDQQGTGGRTLVGASPEVHVRMSGGTVVMNPISGTYRYPAGGPTPEHLLDFLADGKEIEELSMVVDEELKMMCTVGDMGGVVIGPRLKEMAHLAHTEYELRGRSSLDVRDVLKETMFAATVTGSPVQNACRVIERHEVGGRGYYAGALALVGRDAGGAQTLDSPILIRTADIDAGGRLRVPVGATLVRGSDPASEVQETHAKAAGVLAALGVRPGRPRGEGVRPALADDPRVQAALDGRRAALAPFWLRMQEKAAALEGHALVVDAEDTFTAMLAHLLRSSGLTVSVRRYDEPGLREAVLAHEGPVVLGPGPGNPSEEADPKMQFLRALTADVLRDHGHGVLGVCLGHELIAAELGLEIVRKEVPYQGAQTDVDLFGRSETVGFYNSFVARCDDDAAVELAAHGVEVSRDAASGEVHALRGPGFAGVQFHPESVLSLRGADVVRELLAQLLGAEGTRTFSERRPAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K0K1</accession>
    <name>A0A2M9K0K1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_05860</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000002">
        <property type="protein sequence ID" value="PJN12557.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN12557">
        <property type="protein sequence ID" value="PJN12557"/>
        <property type="gene ID" value="CG723_05860"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="16"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="36"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="129"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="167"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="368"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="465"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="465"/>
            <end position="483"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN12557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="493" mass="50218" checksum="8A0A95032145FD34" modified="2018-04-25" version="1">MSTEQTQDRHRGRSPLAVASVAAAVLLVGGGGAYFAATSADGDGRGGSPAAGDGSAPPPLALDGYREGGTGSTSGIAPGEPDPNGTRYRADGKLPTGPGDAPVYRTEGKVTAADVAELARTLDAQGTPRLENGAWKVGPAKDGSGPSLQVTERAPGAWTYARYAPSAGHKCASPTKCTEAPGNGSTKDAVSEDAAKKAAAPVLKALGQDDAKLDARQLMGAIRVVNAEPRVGDLPTYGWTTGVQVGSDGQVVGGSGQLKKPAKGDTYPVISAQKTLDLLNSTAVGAGRVGIGGCASPVPVQERDEAPCKAPTKLPAAEPVHVTGATFGLAAQFTQGRQILVPSWLFQVKPQGGQAAFTVTHPAVDPKFLTAPQAQGPTGKPSPRPSVQPGDPGTDTRDVRPDGYTGDGRTLTAHFTGGVCSTYTASATEQDGKVALKVTETRKKGTVCVAMAKFYTLPVTLDEPLDGRKVVDSNDKAVPHADGRQGHEPAPQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K0N2</accession>
    <name>A0A2M9K0N2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Enoyl-CoA hydratase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_06620</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000002">
        <property type="protein sequence ID" value="PJN12691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN12691">
        <property type="protein sequence ID" value="PJN12691"/>
        <property type="gene ID" value="CG723_06620"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN12691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="297" mass="32547" checksum="F5C929923E6BD0F9" modified="2018-04-25" version="1">MPAAHDSPERVSQDGPEPAPTEPVLYERRGPVAYVTMNRPRYRNAQNSAMTYALDAAFYRAADDPDVKVVVLAGAGDHFSAGHDIGTPERDAHLPFERRAGLWWDHSDKRGAESRFARESEVYLGMCRRWRELPKPVIASVHGACVAGGLMLAWVCDLIVASDDAFFADPVVRMGIPGVEYFAHPWVMPPRVAKEFLFTGDRMTARRAYEVGMVNRVVPCGELAGAAHELALRVAEMPRLGLALTKRAVNQAEDLQGLHAGMDSVFGLHHLAHAHNAETAKDSLGGMDVRAMKEANA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K1G7</accession>
    <name>A0A2M9K1G7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ABC transporter substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_04875</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000002">
        <property type="protein sequence ID" value="PJN12971.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN12971">
        <property type="protein sequence ID" value="PJN12971"/>
        <property type="gene ID" value="CG723_04875"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005693">
        <property type="entry name" value="Mce"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003399">
        <property type="entry name" value="Mce/MlaD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024516">
        <property type="entry name" value="Mce_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11887">
        <property type="entry name" value="Mce4_CUP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02470">
        <property type="entry name" value="MlaD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00996">
        <property type="entry name" value="Mtu_fam_mce"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MlaD" evidence="1">
        <location>
            <begin position="33"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="domain" description="Mce4_CUP1" evidence="2">
        <location>
            <begin position="114"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF11887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN12971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="335" mass="34568" checksum="CF4119E61A42849F" modified="2018-04-25" version="1">MSGRRRHIVVGVVVLAVLAAGGLVGVRALGGGGTTVTAYFDRAVGVYAGSDVRILGVRVGSVGSVHPQGKQVRVILGLDEGVRVPEGARAVVVAPSIVADRYVQLTPAYTAGPALAAGAVLPASRNRTPVEIDQLYDSITELGDALGPNGANAQGALSDLLDTGAKNLDGNGTAIGESIEQFGKAAKTLDGSSDDLFTTLAQLQAFTTMLKDKDGGVRTAQERLDDVVGFFADNKDDLTGALKELGTALGQVKTFIEDNRGELKKNVDKLVPITQTLVRQRASLAEALDTAPLATGNVVNTYDKDGRTLDGRTNLNEISMGGDLLPLPAVGGGGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-06-02" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K225</accession>
    <name>A0A2M9K225_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_00265</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000001">
        <property type="protein sequence ID" value="PJN13077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN13077">
        <property type="protein sequence ID" value="PJN13077"/>
        <property type="gene ID" value="CG723_00265"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="SSF50494"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014605232" evidence="2">
        <location>
            <begin position="34"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="33"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="110"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="35"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="70"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="110"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN13077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="400" mass="42358" checksum="3BD4C9D2699B97CD" modified="2018-04-25" version="1">MRSTRPSSMRSRGRRTVLAATGLAAALALTATACGPSDDKTSDKSAASASQGAGDGSNGQLPGGIADQLKKHGIDPDKWQNGAWKNWDKDDWLREAKDFVNPVIKDHWKPERMKSAKDPDKTIAAKDASADQGATDPEPQPVKAVPEKTPYHDNAAPVGKVFFDSPEGSMVCSGTVVKDPRNPGKSNLVWTAGHCVHAGSAGGWYRNIAFVPAYNDLGKSEAQLQNAAPQEIAPYGTFWADWASTSNEWIDTGAESGGAGAPYDYAVLHVKPEQGSKSLEETVGNALPVDFSEPAVQSVSSMGAWGYPAAPPFNGQLMHKCIDRPGRLSLSPDMPTMYRIGCTMTGGSSGGGWFRMVDGKTQLVSNTSIGPAGNTWLAGPQLGKGAQQVFDTMSEKYGSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K293</accession>
    <name>A0A2M9K293_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">2-aminobenzoate-CoA ligase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_00995</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000001">
        <property type="protein sequence ID" value="PJN13200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN13200">
        <property type="protein sequence ID" value="PJN13200"/>
        <property type="gene ID" value="CG723_00995"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-binding" evidence="1">
        <location>
            <begin position="52"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding_C" evidence="2">
        <location>
            <begin position="456"/>
            <end position="531"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN13200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="544" mass="58688" checksum="7C3FD691DD690C48" modified="2018-04-25" version="1">MTDAPPQHTSAHVDTFARDHLPPRELWPDLVFDLPELRYPQRLNCGAELLDRTVERFGAEPPAFRTGDGEVWTYGELLRRVDRIAHVLSGELGVRPGNRVLLRGPTTPWLAACWLAVMKAGAVAVTVLAQARSQELATICSIARVTHALCDARTMDDLVKAEVPGLRVTPFGGEGPDDLLRRGSGQPETYDAVATAADDVALIAFTSGTTGRPKGCMHFHRDVLAIADTFARHVLRPRPDDVFAGSPPLGFTFGLGGLVVFPLRAGASSLLLEQAGPRQLLPAIAEHGVSVLFTAPTAYRALLDGIDGTDGHALSSLRRCVSAGENLPAATWRAWHEATGIRIINGIGATELLHIFISAADDAIRPGTTGVPVPGWQARVIDAAGAEVPDGEPGLLAVRGPVGCRYLADERQTTYVRGGWNVTGDTYVRDPDGYFRYVARADDMIISAGYNIAGPEVEDALLRHPDVAETAVVGRPDDERGQIAVAFVVLREGARRDPDALRAFVKAELVPYKCPREIVFLDALPRTATGKLQRFRLRSTGDLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K2W1</accession>
    <name>A0A2M9K2W1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Gamma-glutamyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CG723_02595</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000001">
        <property type="protein sequence ID" value="PJN13474.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN13474">
        <property type="protein sequence ID" value="PJN13474"/>
        <property type="gene ID" value="CG723_02595"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.246.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043138">
        <property type="entry name" value="GGT_lsub_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043137">
        <property type="entry name" value="GGT_ssub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="SSF56235"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PJN13474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="611" mass="64356" checksum="1B06C50F63996F90" modified="2018-04-25" version="1">MFTTRPTLQGTFGMVSSTHWLASQSAMAVLESGGNAYDAAVAAGFVLHVVEPHLNGPAGEVPIILAPAGGEVSVLCGQGVAPAGATVAHYRSLGLDLVPGTGPLAAAVPGAFDAWMLLLKDHGTKSLAEVLSYAIGYAEDGHAPVERVGETVDTVRALFENEWHSSAEVYLKDGASPKPGELFRNPQLAATWRRVIEEAEESAGDDRVAQIEAARAIWREGFIAEALVRQAGRPTMDTSGTHHTGTLTAADLAGWSATYEAPATYDWNGWTLCKAGGWSQGPAFLQQLALLPDELPAYGSAEYVHLLIEGCKLAMADREAWYGDAGPEDVPVAELLSDEYNATRRALVGDKASHELRPGSPRGTEPRISAHAHAVAAGEDGFDAMGVAGAGAGEPTVAKSGDQEVAADGATRGDTCHLDIVDRWGNMVAATPSGGWLQSNPVVPELGFPLGTRLQMAWLDEGLPNSLAPGRRPRTTLTPSLALKDGVPVLAFGTPGGDQQDQWQVHFFLAVALRAAVRGGLDLQGAVDAPNWHNDSFPGSFYPRGMRPGSVTVESRIGEDVIEELRRRGHDVTVGEPWSEGRLCAVARDPETGVLSAAANPRGMQGYAVGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K383</accession>
    <name>A0A2M9K383_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GntR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_03245</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000001">
        <property type="protein sequence ID" value="PJN13588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN13588">
        <property type="protein sequence ID" value="PJN13588"/>
        <property type="gene ID" value="CG723_03245"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07377">
        <property type="entry name" value="WHTH_GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1410.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028978">
        <property type="entry name" value="Chorismate_lyase_/UTRA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011663">
        <property type="entry name" value="UTRA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
        <property type="entry name" value="GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07702">
        <property type="entry name" value="UTRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00035">
        <property type="entry name" value="HTHGNTR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00345">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00866">
        <property type="entry name" value="UTRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64288">
        <property type="entry name" value="SSF64288"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50949">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH gntR-type" evidence="1">
        <location>
            <begin position="7"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN13588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="247" mass="27486" checksum="E2794B68DD95BBF9" modified="2018-04-25" version="1">MAAPGRDSAYVRLARELREAILRHDYPEGVRLPTEAELAASHGLSRQTVRRAFQDLVTEGLVHRVPGRGTFAAPREEQYLRQFGSVEDLMALSLDTTMRLVSPLRRRVDVDAAGRLRVGSDRVDHLSFLRLHEDTPFCLTTVHLPPDVGALVADRPELTEAGADSRVTVIGLLDGRLPEPIAEAEQSVTVALASAEVAAHLDCPPQHPLLRIDRLYLSASGRPVELAVSHFLPEHYSYRVRLRRHPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K3D8</accession>
    <name>A0A2M9K3D8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_03605</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000001">
        <property type="protein sequence ID" value="PJN13644.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN13644">
        <property type="protein sequence ID" value="PJN13644"/>
        <property type="gene ID" value="CG723_03605"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000551">
        <property type="entry name" value="MerR-type_HTH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13411">
        <property type="entry name" value="MerR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00040">
        <property type="entry name" value="HTHMERR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00422">
        <property type="entry name" value="HTH_MERR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="SSF46955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50937">
        <property type="entry name" value="HTH_MERR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH merR-type" evidence="1">
        <location>
            <begin position="9"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN13644.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="243" mass="26977" checksum="8A0A27216FB0307C" modified="2018-04-25" version="1">MTTDTGEPTLTVDELAARAGVTVRTIRFYSTKGLLPPPVIGPRRVGHYGRDHLSRLALIEELQHQGMTLSAIERYLEQLPADLSADDLAIHRALVASWAPDAAEDVTRAELERRAGRPLSGEDLDRLAAMGVVAYLEDSDTFRVDPGLLRLGVELLGVPIAHETILAARTVLMKHTRDAAQELTRLFRDEVWGPYRERESDPEHVAAMKSLSAHMQPMVVQALVTAFQRSLKEQLREAFRAEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K3F2</accession>
    <name>A0A2M9K3F2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">GntR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CG723_03075</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000001">
        <property type="protein sequence ID" value="PJN13557.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN13557">
        <property type="protein sequence ID" value="PJN13557"/>
        <property type="gene ID" value="CG723_03075"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07377">
        <property type="entry name" value="WHTH_GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.530">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011711">
        <property type="entry name" value="GntR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008920">
        <property type="entry name" value="TF_FadR/GntR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07729">
        <property type="entry name" value="FCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
        <property type="entry name" value="GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00035">
        <property type="entry name" value="HTHGNTR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00895">
        <property type="entry name" value="FCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00345">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48008">
        <property type="entry name" value="SSF48008"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50949">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH gntR-type" evidence="4">
        <location>
            <begin position="18"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PJN13557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="225" mass="24805" checksum="0A45B4F2B0990190" modified="2018-04-25" version="1">MLSTGLPQGAVPKLERPGPLRERVYEALLELITTRALQPGQHLVESELAGHLGVSRQPVREALQRLNTEGWVDLRPAQGAFVHEPTEDEADQLLTVRTLLEAEAARLAAANAGKAGIAALEELCARGEQAVADGDVELVVATNAAFHAKVMELAGNVVLGELAGQVDRRVRWYYQPVARQRGKQSWIEHRELIAAIAQRDEARATAVMRAHTEHTRETYHRREQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K3J2</accession>
    <name>A0A2M9K3J2_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">L-threonine 3-dehydrogenase</fullName>
            <shortName evidence="6">TDH</shortName>
            <ecNumber evidence="6">1.1.1.103</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">tdh</name>
        <name evidence="9" type="ORF">CG723_03940</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CB01635</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the NAD(+)-dependent oxidation of L-threonine to 2-amino-3-ketobutyrate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>L-threonine + NAD(+) = (2S)-2-amino-3-oxobutanoate + H(+) + NADH</text>
            <dbReference type="Rhea" id="RHEA:13161"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57926"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:78948"/>
            <dbReference type="EC" id="1.1.1.103"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="6">Binds 2 Zn(2+) ions per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="6">Amino-acid degradation; L-threonine degradation via oxydo-reductase pathway; glycine from L-threonine: step 1/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.103" evidence="6"/>
    <dbReference type="EMBL" id="NNBL01000001">
        <property type="protein sequence ID" value="PJN13698.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN13698">
        <property type="protein sequence ID" value="PJN13698"/>
        <property type="gene ID" value="CG723_03940"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00046">
        <property type="reaction ID" value="UER00505"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008743">
        <property type="term" value="F:L-threonine 3-dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019518">
        <property type="term" value="P:L-threonine catabolic process to glycine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00627">
        <property type="entry name" value="Thr_dehydrog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004627">
        <property type="entry name" value="L-Threonine_3-DHase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00692">
        <property type="entry name" value="tdh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 6" id="KW-0520">NAD</keyword>
    <keyword evidence="4 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="ADH_N" evidence="8">
        <location>
            <begin position="26"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="domain" description="ADH_zinc_N" evidence="7">
        <location>
            <begin position="174"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="6">
        <location>
            <position position="40"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="6">
        <location>
            <position position="43"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="38"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="63"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="64"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="93"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="96"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="99"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="107"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="175"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="195"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="200"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="262"/>
            <end position="264"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="286"/>
            <end position="287"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="site" description="Important for catalytic activity for the proton relay mechanism but does not participate directly in the coordination of zinc atom" evidence="6">
        <location>
            <position position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00627"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF08240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PJN13698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="342" mass="36413" checksum="8FF0D45A880DBE17" modified="2018-04-25" version="1">MKALVKEKSEPGLWLTDVPEPSIGHGDVLIKVLRTGICGTDLHIRNWDGWAQQAISAPLIVGHEFVGEVVETGRDVADIAIGDRVSGEGHLVCGKCRNCLAGRRHLCRSTVGLGVGRDGAFAEYVALPAANVWVHRVPVDLDVAAIFDPFGNAVHTALSFPLVGEDVLITGAGPIGLMAAAVARHAGARNVVVTDVSEERLDLARKIGVSLALNVAESTIAEGQRSLGLREGFDVGLEMSGNPVAMRDMIANMTHGGKIAMLGLPAEEFAVDWSRIVTSMITIKGIYGREMFETWYAMSVLLEGGLDLAPVITGRYGHRDFEAAFDDAASGRGGKVILDWTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JEM9</accession>
    <name>A0A2M9JEM9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GNAT family N-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_45320</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000052">
        <property type="protein sequence ID" value="PJN05356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN05356">
        <property type="protein sequence ID" value="PJN05356"/>
        <property type="gene ID" value="CG723_45320"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13302">
        <property type="entry name" value="Acetyltransf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="36"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN05356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="189" mass="21467" checksum="6B825DBF24568EF1" modified="2018-04-25" version="1">MEPNALESALGPGDVPERIEAEGLVLRRWEPDDLDDRYRAITASFHHLHPWMEWASEPPTEEEHRERFRHALRWPSGGSYNFGIFDLRSGAILGVASVHDQLGPGRVEIGYWCHVDHIGRGVISRSARGLTRILLSLPHVKRIEIHCDEANLRSAAVPERLGYRLDRIEDDGIEAPAESGRGMVWIKER</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JEP9</accession>
    <name>A0A2M9JEP9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CG723_45275</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000052">
        <property type="protein sequence ID" value="PJN05349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN05349">
        <property type="protein sequence ID" value="PJN05349"/>
        <property type="gene ID" value="CG723_45275"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001646">
        <property type="entry name" value="5peptide_repeat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13576">
        <property type="entry name" value="Pentapeptide_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PJN05349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="66" mass="6836" checksum="CFDE9A33EBB5DC54" modified="2018-04-25" version="1">MATAWCLHDFNFTGAVFDGGAFATSHFRGAVSFYGATFSSGTVTVRGATFSGTRIDWGPLPVLAGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-09-29" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JF04</accession>
    <name>A0A2M9JF04_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CG723_44580</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CB01635</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000048">
        <property type="protein sequence ID" value="PJN05468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN05468">
        <property type="protein sequence ID" value="PJN05468"/>
        <property type="gene ID" value="CG723_44580"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004638">
        <property type="entry name" value="EmrB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00711">
        <property type="entry name" value="efflux_EmrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="37"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="67"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="91"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="126"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="153"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="186"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="217"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="256"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="291"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="325"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="438"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="1"/>
            <end position="462"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PJN05468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="472" mass="48356" checksum="2C4D7BE00A7FDAF6" modified="2018-04-25" version="1">MAVIALAQLMVILDGTIVNIALPSAQHSLGMSDADRQWVITAYTLAFGGLLLLGGRIADLLGRKRTFVIGLAGFAAASALGGAAAGPGMLFAARALQGAFAAVLAPSALSLLTTTFTDPKERARAFGVYGALAGGGSAVGLIVGGLLTEYLNWRWSLYVNVPIALAALLGAPAFLRDRSGRRGGHLDVPGALLGCGGLVALVYGFSEAEPRGWTSPSVLTLLVAGVILLAAFVWWQSRAASPLLPLRIVKDRVRAGSLATMGLATIGMFGVFLFLTYYLQVVLGYPPVRTGLAFVPISAGIVIGATQIAARLLPRTAPRTLMSSGMVLAAVGMVLLSSLTVHAQYVPHVLPSLLLLGLGMGLTFMPVYATATAGVPAQDAGVASAVLNTVQQMGASLGTVLLNTIATGAASRYVHSHVHDPAHGGATLDEGMVHGFSVAYWCSAGVLLLAALVAGLTVRPKTPKHAGDDAPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JF20</accession>
    <name>A0A2M9JF20_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_44865</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000049">
        <property type="protein sequence ID" value="PJN05403.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN05403">
        <property type="protein sequence ID" value="PJN05403"/>
        <property type="gene ID" value="CG723_44865"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2840">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025736">
        <property type="entry name" value="PucR_C-HTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042070">
        <property type="entry name" value="PucR_C-HTH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13556">
        <property type="entry name" value="HTH_30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH_30" evidence="1">
        <location>
            <begin position="320"/>
            <end position="374"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN05403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="379" mass="40516" checksum="DAF40FB343312B8D" modified="2018-04-25" version="1">MSHAIRRASELALDETTVTALRAALKSTADEIVQAIIDEVPPYANALSGRMGGTIRRAVRTALGHYLDLASGIATGGDAGDAAYELGRGEVRDGRSMDALLSAYRVGARVAWRCLAAGAVPAGLPAAEVAKFAELTFAYIDELSAASAAGHADELAARGRAHERHLEHLARDLLAGASPDVLLASVQRAGWQPPVSLTAVLLPAAQAWPAYRALDPSTLVLDDLPDATGVLLVPDADRSHLLRQLTDRTAVVGPARPWTRASASYARAVRARSLSSDIRDTEDHLPELVLSADVDAFADLRARALAPLRALPVATARRLEETLRAWLLHQGRRDEVAAALFVHPQTVRYRMSQLRELFPDLASPHRVLELTLAVGLGVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JF31</accession>
    <name>A0A2M9JF31_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_44375</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000047">
        <property type="protein sequence ID" value="PJN05484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN05484">
        <property type="protein sequence ID" value="PJN05484"/>
        <property type="gene ID" value="CG723_44375"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.850">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000868">
        <property type="entry name" value="Isochorismatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036380">
        <property type="entry name" value="Isochorismatase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00857">
        <property type="entry name" value="Isochorismatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52499">
        <property type="entry name" value="SSF52499"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Isochorismatase" evidence="1">
        <location>
            <begin position="10"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN05484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="186" mass="19815" checksum="AE502082A70F68E3" modified="2018-04-25" version="1">MTLTAMDARTALLVVDLQEGILGLPTVHPTAEITDRAAELAAVFRAHELPVVLINVAGGAPGRNEMPKSTSTPAPNWTDLAAQLKAEDSDHRVTKKTWDAFPATDLHDYLQSHNVTQVVLVGIATSIGVESTARSAYALGYNVTLATDAMTDMDPEAHRNSLERVFPKLGETGSTAEVAALVQSSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JFA2</accession>
    <name>A0A2M9JFA2_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ethanolamine-phosphate cytidylyltransferase</fullName>
            <ecNumber evidence="4">2.7.7.14</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">CTP:phosphoethanolamine cytidylyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CG723_44570</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CB01635</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Lipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Phospholipid metabolism; phosphatidylethanolamine biosynthesis; phosphatidylethanolamine from ethanolamine: step 2/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytidylyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.14" evidence="4"/>
    <dbReference type="EMBL" id="NNBL01000048">
        <property type="protein sequence ID" value="PJN05437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN05437">
        <property type="protein sequence ID" value="PJN05437"/>
        <property type="gene ID" value="CG723_44570"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00031">
        <property type="reaction ID" value="UER00007"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00558">
        <property type="reaction ID" value="UER00742"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004306">
        <property type="term" value="F:ethanolamine-phosphate cytidylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006646">
        <property type="term" value="P:phosphatidylethanolamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004821">
        <property type="entry name" value="Cyt_trans-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044608">
        <property type="entry name" value="Ect1/PCYT2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45780">
        <property type="entry name" value="PTHR45780"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01467">
        <property type="entry name" value="CTP_transf_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00125">
        <property type="entry name" value="cyt_tran_rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="CTP_transf_like" evidence="6">
        <location>
            <begin position="14"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00024191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00024221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00031473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PJN05437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="140" mass="15356" checksum="B851050CEC8B3FB7" modified="2018-04-25" version="1">MAERGTVYVDMVGDLFHPGHVALLRAARDFGERLMVGVLSDEIVAGYKRRPIMTLAERIAVIEACRYVDVVLPDAPYRVTNEFLDRHGIDVVVHGDDLTADAVEEVFGPVADAGKLRLVRYTAGVSTTELIQRCRAADAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-06-02" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JFC3</accession>
    <name>A0A2M9JFC3_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CsbD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CG723_43625</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CB01635</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0337 (CsbD) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000044">
        <property type="protein sequence ID" value="PJN05595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN05595">
        <property type="protein sequence ID" value="PJN05595"/>
        <property type="gene ID" value="CG723_43625"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008462">
        <property type="entry name" value="CsbD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036629">
        <property type="entry name" value="YjbJ_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05532">
        <property type="entry name" value="CsbD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69047">
        <property type="entry name" value="SSF69047"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CsbD" evidence="3">
        <location>
            <begin position="5"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="8"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PJN05595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="63" mass="7055" checksum="7E93B412D6881224" modified="2018-04-25" version="1">MTGRGGLDKIKGKAKEVTGKITGDRRKEAEGKGDQVKGEAKRVMREVHDRARGARDSLRRRHN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JFI4</accession>
    <name>A0A2M9JFI4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CG723_43375</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000043">
        <property type="protein sequence ID" value="PJN05656.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN05656">
        <property type="protein sequence ID" value="PJN05656"/>
        <property type="gene ID" value="CG723_43375"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PJN05656.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="225" mass="24825" checksum="AA510FE14A6B2FAF" modified="2018-04-25" version="1">MDADLQGMGDRIKILPDMDAVISALTEEVQASELSAETSAALNGLSQTIGELAIKLMRTGAYQQATLLSKLDRKGQLKRVTFRRWVAPPDAELLGVSNVTGHRINDSVWFIADVEWLLWGVSQSFVPNFGVVPVACIWETRVLMTTSGVERPTILTDRTITKPLPPERRDTWGPIVERVFGPLDELMTEEGQSLVAKLLMDYSEENRDLLSFIPTLIVDDEGGGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-05-25" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JFR7</accession>
    <name>A0A2M9JFR7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Aldo/keto reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_43175</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000042">
        <property type="protein sequence ID" value="PJN05734.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN05734">
        <property type="protein sequence ID" value="PJN05734"/>
        <property type="gene ID" value="CG723_43175"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NADP_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="SSF51430"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldo_ket_red" evidence="1">
        <location>
            <begin position="15"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN05734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="327" mass="34944" checksum="70BEE03DC2375960" modified="2018-04-25" version="1">MEQRHLGRTGLRVSRIGLGTLTWGRDTDEHDAADLLKTFWEAGGTLVDTADVYGGGEAEYLLGQLVEGLVPRRDLVISTKAGSVPDPDRRFDGSRGHLLAALDASLARLGTDYVDLWQVHAFDTATPLDETLQALDIAVSSGRARYAGVSNFCGWQLAKAGTWQLAAPGIRTRLASTQMEYSLLQRGVEREVLPAALDLGIGLLPSSPLGRGVLTGKYRKATPADSRGASDHMAPFVAPYLDDAATRIVDAVITAADGLAVTPLQVALAWVRDRPGVAAPIIGARNSQQLTAALSVEALSLPDEICQALDDVSTPVHRYPDQDWSTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JFS0</accession>
    <name>A0A2M9JFS0_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">M20_dimer domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_43205</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000042">
        <property type="protein sequence ID" value="PJN05740.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN05740">
        <property type="protein sequence ID" value="PJN05740"/>
        <property type="gene ID" value="CG723_43205"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001261">
        <property type="entry name" value="ArgE/DapE_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036264">
        <property type="entry name" value="Bact_exopeptidase_dim_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002933">
        <property type="entry name" value="Peptidase_M20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011650">
        <property type="entry name" value="Peptidase_M20_dimer"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07687">
        <property type="entry name" value="M20_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01546">
        <property type="entry name" value="Peptidase_M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55031">
        <property type="entry name" value="SSF55031"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00758">
        <property type="entry name" value="ARGE_DAPE_CPG2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="M20_dimer" evidence="2">
        <location>
            <begin position="206"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN05740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="446" mass="48116" checksum="7DFC74A0AA2B0772" modified="2018-04-25" version="1">MGGTGVSESSTGRTVSGEDEVVDLCRELIQIDTSNYGDHSGPGERKAAEYVAEKLAEVGLEPKIFESHPGRASTVARIQGEDPSRPALLIHGHTDVVPANAADWTHHPFSGEIADGCVWGRGAVDMKDMDAMTLAVVRDRLRSGRKPPRDIVLAFLADEEAGGTYGARHLVDKHPDLFEGCTEAISEVGGFSFTVNEKLRLYLVETAQKGMHWMKLTVDGTAGHGSMIHKDNAITELSEAVGRLGRHKFPVRVTKTLRHFLDELGDALGTELDPENMDETLAKLGGIAKLIGASLQNTANPTQLGAGYKVNVIPGQATAHIDGRYLPGYEEEFLADLDRILGPNVQREDVHADKALETTFDGALVDAMQTALQAEDPIARAVPYMLSAGTDAKSFDDLGIRGFGFAPLKLPPELDFAGMFHGVDERVPVDGLKFGVRVLDRFIDAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JG27</accession>
    <name>A0A2M9JG27_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CG723_42840</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000041">
        <property type="protein sequence ID" value="PJN05802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN05802">
        <property type="protein sequence ID" value="PJN05802"/>
        <property type="gene ID" value="CG723_42840"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.690">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045372">
        <property type="entry name" value="YidB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027405">
        <property type="entry name" value="YidB-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20159">
        <property type="entry name" value="YidB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140804">
        <property type="entry name" value="SSF140804"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PJN05802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="138" mass="13487" checksum="178EC21E8F533F2F" modified="2018-04-25" version="1">MAGNNDLGSLLSGLLGDKAGGSAGGVLTSLLAAFAKSQGGSAGGNPLGGLLETLAKSGLGGQAQSWVGTGSNEQLTPDQVKEALPDATLQKVAAESGVSPDQAAHDIASALPTAVDKLTPQGEVPSVSLDELVKAQKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JGM5</accession>
    <name>A0A2M9JGM5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GNAT family N-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_41225</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000036">
        <property type="protein sequence ID" value="PJN06031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN06031">
        <property type="protein sequence ID" value="PJN06031"/>
        <property type="gene ID" value="CG723_41225"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13302">
        <property type="entry name" value="Acetyltransf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="11"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN06031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="176" mass="19795" checksum="176F9A425FADFB8D" modified="2018-04-25" version="1">MDPVTLETDRLLLRAFTPADVDAVYEACQDEDIQFYTPVPVPYRRADAEKLVGEKLPAQWAEDKDYTLGAFRKDTGALVGSYCLTLISRGVWELGYWTVKEQRGRGYSVEAAQALCDWGWATLDVHRIEWWAMAGNTGSRAVAEKLGFTVEGTLRNRSIANDGKPHDWWVGGLLRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-09-29" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JGW2</accession>
    <name>A0A2M9JGW2_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">LTD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_41575</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000036">
        <property type="protein sequence ID" value="PJN06082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN06082">
        <property type="protein sequence ID" value="PJN06082"/>
        <property type="gene ID" value="CG723_41575"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1260">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001322">
        <property type="entry name" value="Lamin_tail_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036415">
        <property type="entry name" value="Lamin_tail_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00932">
        <property type="entry name" value="LTD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74853">
        <property type="entry name" value="SSF74853"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51841">
        <property type="entry name" value="LTD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LTD" evidence="2">
        <location>
            <begin position="1"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN06082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="112" mass="13031" checksum="9947548297217949" modified="2018-04-25" version="1">MSGVQYDSPGRDDRSNRSLNNEWVNITNPTRSAVNLNGWTLSDRDGHTFTFHHFTLRAHATVRVHTGIGRDTRTDLFQDRRAYVWDNNGDTTTLRNDRRRIIDGGSWGHHRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JHH7</accession>
    <name>A0A2M9JHH7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">3-hydroxy-3-methylglutaryl-ACP synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CG723_40010</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CB01635</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the thiolase-like superfamily. HMG-CoA synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000032">
        <property type="protein sequence ID" value="PJN06330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN06330">
        <property type="protein sequence ID" value="PJN06330"/>
        <property type="gene ID" value="CG723_40010"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004421">
        <property type="term" value="F:hydroxymethylglutaryl-CoA synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006084">
        <property type="term" value="P:acetyl-CoA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010142">
        <property type="term" value="P:farnesyl diphosphate biosynthetic process, mevalonate pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013746">
        <property type="entry name" value="HMG_CoA_synt_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013528">
        <property type="entry name" value="HMG_CoA_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08540">
        <property type="entry name" value="HMG_CoA_synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01154">
        <property type="entry name" value="HMG_CoA_synt_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HMG_CoA_synt_N" evidence="2">
        <location>
            <begin position="2"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="domain" description="HMG_CoA_synt_C" evidence="3">
        <location>
            <begin position="265"/>
            <end position="365"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PJN06330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="415" mass="44913" checksum="A2AB6D69CF7E2998" modified="2018-04-25" version="1">MKQVGIEAINAYCGETYIDVPALFAARGLDDSRIGNLMMARKSVALHCEDAVSFAVNAAKPIVDALSAEERDSIELLIVGTESGVDFGKSLATYVHDYLGLSRSCRLFETKQACYSGTAALQMAAAVVAASPFEGTKALVISSDVARPVPHTYVEPSQGAGAMAMLVSDNPVVAAFDQGANGFHSYEVMDTCRPDPEREAGDTDLSLLTYIDCLKGSFTDYARKVDGADFVDSFDLLAMHTPFPGMVKGAHRAALRKLKRGTSPQAVEDDFTTRLGPAIQYPQQVGNIYAGTVFLALASTIDNAVIDGERRVGVFSYGSGCASEFYSAVITPASQRAVRAMGIREALDARYALSTDEYDELLSATAELKFGTQDFTFDLDRFPQITKARFDGGRRLVLRGVRDYHREYVWLGGDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-09-29" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JHP2</accession>
    <name>A0A2M9JHP2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DEAD/DEAH box helicase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_39690</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000031">
        <property type="protein sequence ID" value="PJN06406.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN06406">
        <property type="protein sequence ID" value="PJN06406"/>
        <property type="gene ID" value="CG723_39690"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021904">
        <property type="entry name" value="DUF3516"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12029">
        <property type="entry name" value="DUF3516"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0347">Helicase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="1">
        <location>
            <begin position="56"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="2">
        <location>
            <begin position="236"/>
            <end position="432"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN06406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="854" mass="94974" checksum="40DED0A495083DFD" modified="2018-04-25" version="1">MQATDCRIGSEGRQDGGVTLIDQLPQTADPDALYEAFESWAVERGITLYPHQEEALIEVVSGANVIVSTPTGSGKSMIAAGAHFAALARDEVTFYTAPIKALVSEKFFELCKLFGTENVGMLTGDASVNADAPVICCTAEILASIALRDGARADIGQVVMDEFHFYAEGDRGWAWQIPLLELPQAQFILMSATLGDVAMFEKDLTRRTGRPTSVVSSATRPVPLSYEYRLTPLTETLTELLDTRQAPVYIVHFTQAQAVERAQALMSINMCTREEKEKIADLIGNFRFTTKFGRNLSRYVRHGIGVHHAGMLPKYRRLVEKLAQAGLLKVICGTDTLGVGVNVPIRTVLFTALTKYDGTRVRTLRAREFHQIAGRAGRAGFDTAGLVVAQAPEHVIENEKALTKAGDDPKKRRKVVRKKAPEGFVGWTENTFEKLIGSAPEPLTSRFRVTHMMLLAVIARPGNAFAAMRHLLEDNHEPRKQQLRHIRRAIAIYRSLLDGGIVEKLDVPDSTGRIVRLTVDLQQDFALNQPLSTFALASFDLLDPDSPSYALDMVSVVESTLDDPRQILAAQQNKARGEAVAAMKSDGVEYEDRMERLQDITYPKPLEELLFHAYDVYRRSHPWVGDHPLSPKSVIRDMYERAMTFTEFVSFYELARTEGIVLRYLAGAYKTLEHTVPDDLKSEDLEDLIAWLGEMVRQVDSSLLDEWEQLANPEVMTAEEAQEKADQVKPVTANARAFRVLVRNAMFRRVELAALDNVDELGELDADAGWDADAWGEAMDKYWDEYEDLGTGPDARGPKLLQIEENAAHGLWRVRQTFADPNGDHDWGISAEVDLEASDAEGRAVVRVTDVGQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JHZ6</accession>
    <name>A0A2M9JHZ6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Arsenic transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CG723_38675</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CB01635</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000029">
        <property type="protein sequence ID" value="PJN06473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN06473">
        <property type="protein sequence ID" value="PJN06473"/>
        <property type="gene ID" value="CG723_38675"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015105">
        <property type="term" value="F:arsenite transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000802">
        <property type="entry name" value="Arsenical_pump_ArsB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02040">
        <property type="entry name" value="ArsB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00758">
        <property type="entry name" value="ARSENICPUMP"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="31"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="59"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="104"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="175"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="218"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="246"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="274"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="314"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="394"/>
            <end position="416"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PJN06473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="417" mass="42857" checksum="E0F9A007F23C9927" modified="2018-04-25" version="1">MSTVPAELLSVTLLLLILGFAVVRPRQLPEAVVAVPAAAIVVAVGAVSPAHAWAETRELLPVVGFLAAVLVLAQLCADEGLFKAAGDAIARACKGSPRRMLGGVFAAAAVITAVLSLDATVVLLTPVVLATARRIGARPRPHVYASAHLANSASLLLPVSNLTNLLAFTASGLTFARFAGLMALPWLGAIAVEYAVFRRYFADDLAAPAHEPDAEEPPGVPVFTLTVLALTLVGFVVTSFAGIDPLWAAIVGTAVLAARALGQRRTTPLALVKSAHPYFCLFVLALGIVVKAVVDNGLGDGIDRLLPEGSSLLALLAVAGVAALLANLINNLPAVLALLPVAGPAGPGPVLAVLIGVNLGPNLTYVGSLATLLWRRIVHAHDVHPRLGDFTRLGVLTVPATLVVSTVALWAGLQFLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-05-25" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JIW6</accession>
    <name>A0A2M9JIW6_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Enoyl-CoA hydratase 2</fullName>
            <ecNumber evidence="1">4.2.1.119</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Enoyl-CoA hydratase 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CG723_37305</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CB01635</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>a (3R)-3-hydroxyacyl-CoA = a (2E)-enoyl-CoA + H2O</text>
            <dbReference type="Rhea" id="RHEA:26526"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:57319"/>
            <dbReference type="ChEBI" id="CHEBI:58856"/>
            <dbReference type="EC" id="4.2.1.119"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.119" evidence="1"/>
    <dbReference type="EMBL" id="NNBL01000026">
        <property type="protein sequence ID" value="PJN06811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN06811">
        <property type="protein sequence ID" value="PJN06811"/>
        <property type="gene ID" value="CG723_37305"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002539">
        <property type="entry name" value="MaoC-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01575">
        <property type="entry name" value="MaoC_dehydratas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="SSF54637"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="2" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MaoC-like" evidence="5">
        <location>
            <begin position="190"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00029334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00030115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PJN06811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="283" mass="30592" checksum="CD9261FCCCFF3F27" modified="2018-04-25" version="1">MTTVTLTATPSLPPLLARGALLSPLKRPRPGAEAPVTRLVLPAARADRTRLAAYREVCGFDRDAAALPVTYPHVLGFPLAMRIMAGRRFPLPLLGLVHTSLTVTQGHDLPVDEAYELSVYVKELVPHRRGTEATVVTELRAGDTRAWTSTSTYLARHRTDTPPRDNAAPEERPEPLPAVAEWKLPGDLGRRYGAASGDRNPIHLHPLTARLFGFPRAIAHGMWTVARCIAEHGAEGEVQVRAAFKAPVLLPASVTYASRGPAFELRSATRTHVTGEVLRAGGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JIZ0</accession>
    <name>A0A2M9JIZ0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CG723_36805</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000025">
        <property type="protein sequence ID" value="PJN06846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN06846">
        <property type="protein sequence ID" value="PJN06846"/>
        <property type="gene ID" value="CG723_36805"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03255">
        <property type="entry name" value="ABC_MJ0796_LolCDE_FtsE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017911">
        <property type="entry name" value="MacB_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="15"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="51"/>
            <end position="58"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PJN06846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="256" mass="27509" checksum="1830446C9F9BE953" modified="2018-04-25" version="1">MTTTPIAGKATAVAARATDLSKVYGQGETQVVALDRVSVDFRQAEFTAIMGPSGSGKSTLMHCVAGLDNFSSGSVRIGDTELGSLKDKQLTKLRRDKIGFIFQAFNLLPTLTALENITLPMDIAGRRADKQWLENVIAMVGLSDRLGHRPSELSGGQQQRVAVARALASRPEIIFGDEPTGNLDSRSGAEVLGFLRNSVRELGQTVVMVTHDPVAAAYADRVIFLADGRVVDEVYAPTADSVLDRMKQFDAKGRTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JJA2</accession>
    <name>A0A2M9JJA2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">TetR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CG723_36290</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000024">
        <property type="protein sequence ID" value="PJN06955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN06955">
        <property type="protein sequence ID" value="PJN06955"/>
        <property type="gene ID" value="CG723_36290"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025996">
        <property type="entry name" value="TetR_C_WHG"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13305">
        <property type="entry name" value="TetR_C_33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="5">
        <location>
            <begin position="12"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="4">
        <location>
            <begin position="35"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PJN06955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="192" mass="21144" checksum="5757EFD194133096" modified="2018-04-25" version="1">MSVKERKERERASRERLIVATARELAEQQGWDAVTTRQLAERIEYSQPVLYSHFRGKREIIGAVALEGAAEMAAAVRAATAAAHGPRERVYALARAYLDFAARNPAVYDAIFQLDGGLPYAREDTPEPLKDAFAALLESLGEVAGDGVHPGLFTEMFWASLHGLATLTRSGRLPPEDTEPRVELLVDRLAMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JJM5</accession>
    <name>A0A2M9JJM5_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">ATP-dependent zinc metalloprotease FtsH</fullName>
            <ecNumber evidence="5">3.4.24.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">ftsH</name>
        <name evidence="9" type="ORF">CG723_35665</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CB01635</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="5">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homohexamer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
            <orientation evidence="5">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the AAA ATPase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">In the C-terminal section; belongs to the peptidase M41 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">In the central section; belongs to the AAA ATPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.-" evidence="5"/>
    <dbReference type="EMBL" id="NNBL01000023">
        <property type="protein sequence ID" value="PJN07070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN07070">
        <property type="protein sequence ID" value="PJN07070"/>
        <property type="gene ID" value="CG723_35665"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004176">
        <property type="term" value="F:ATP-dependent peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030163">
        <property type="term" value="P:protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.760">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01458">
        <property type="entry name" value="FtsH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005936">
        <property type="entry name" value="FtsH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000642">
        <property type="entry name" value="Peptidase_M41"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037219">
        <property type="entry name" value="Peptidase_M41-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01434">
        <property type="entry name" value="Peptidase_M41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140990">
        <property type="entry name" value="SSF140990"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01241">
        <property type="entry name" value="FtsH_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="9" id="KW-0132">Cell division</keyword>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 5" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="5 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2 5" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="118"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="domain" description="AAA" evidence="8">
        <location>
            <begin position="203"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="620"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="624"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="434"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="211"/>
            <end position="218"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="433"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="437"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="509"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PJN07070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="669" mass="72340" checksum="40B265693DCD703C" modified="2018-04-25" version="1">MDVKRYFRGPVMWIVLAVLAVVVLMQVVGSSGGYKTVDTGQVIQAINDNKVQSAKLTTGDENNIKVELKNDQKVQGSSKIQASYIGDQGVDVAKDLQAKFEDKQIPDGYTVAPTKQNAFVGILLSLLPFVLIVVVFLFLMNQMQGGGSRVMQFGKSKAKLITKDTPKTTFADVAGSDEAVEELHEIKEFLQEPAKFQAVGAKIPKGVLLYGPPGTGKTLLARAVAGEAGVPFYSISGSDFVEMFVGVGASRVRDLFEQAKANAPAIVFVDEIDAVGRHRGAGLGGGHDEREQTLNQLLVEMDGFDVKGGVILIAATNRPDILDPALLRPGRFDRQIAVDRPDMQGRLEILKVHQKGKPVAPDVDLSAVARRTPGFTGADLANVLNEAALLTARSDLKLVDNSMLDEAIDRVVAGPQKRTRIMSDKEKKITAYHEGGHALVAAASPNSDPVHKITILSRGRALGYTMVLPDEDKYSTTRNEMLDQLAYMLGGRAAEELVFHDPTTGAANDIEKATTTARAMVTQYGMTERLGAIKFGGDNTEPFLGREMAHQRDYSEEVAALVDEEVKKLIETAHNEAWEILVENRDVLDNLVLALLEKETLNKEQIAEIFAPIVKRPARPAWTGSSRRTPSTRPPVLSPRELSLTNGSNGAATGVESGLDIAPTDSPEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JJN8</accession>
    <name>A0A2M9JJN8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Ion channel protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CG723_35615</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CB01635</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000023">
        <property type="protein sequence ID" value="PJN07062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN07062">
        <property type="protein sequence ID" value="PJN07062"/>
        <property type="gene ID" value="CG723_35615"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005247">
        <property type="term" value="F:voltage-gated chloride channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014743">
        <property type="entry name" value="Cl-channel_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001807">
        <property type="entry name" value="Cl-channel_volt-gated"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00654">
        <property type="entry name" value="Voltage_CLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00762">
        <property type="entry name" value="CLCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81340">
        <property type="entry name" value="SSF81340"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="31"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="74"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="114"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="143"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="172"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="202"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="243"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="278"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="320"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="346"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="370"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="392"/>
            <end position="417"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PJN07062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="435" mass="44282" checksum="8EF1DADA84075F69" modified="2018-04-25" version="1">MPLSSVYGVPVSTDAQAEPQETTPARTLLPLVVPALVVGVVCSLLFLGVSWLAEQLQHVLWEDLPDALGIGGYSSAWMIVMLTTTGVLVGIVVWKAPGHAGPDPATVGLESAPLPPYVLPGLLVATALMLAGGPSLGPENPIIAANIGLAFWLGSKALPAMPAVLWGTLAEAATLGALFGTPVAAALVISEALAGKPIKGSLWDALFAPLTAAATGALTTSLIGHPSFDLGLPAFPRPDWGDLLSVLVVASAAAVLGMAAVYAFPYTHAAFGRLKHPMLMLPVGGLVLGLLGALGGHLTLFKGLNEVAALAQDPEGWSAGQFALMTVVKLAALLIAASCGFRGGRIFPAVFIGTAFGLLAHALVPGVHPAVGVSAGVLGILLAITRQGWVSLFVAAILVASPPILVLLCIASLPAWLLVTGRPQMQLHDDGTALR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JKJ6</accession>
    <name>A0A2M9JKJ6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Acetoacetate--CoA ligase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_34670</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000021">
        <property type="protein sequence ID" value="PJN07394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN07394">
        <property type="protein sequence ID" value="PJN07394"/>
        <property type="gene ID" value="CG723_34670"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030729">
        <property type="term" value="F:acetoacetate-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005914">
        <property type="entry name" value="Acac_CoA_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032387">
        <property type="entry name" value="ACAS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16177">
        <property type="entry name" value="ACAS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01217">
        <property type="entry name" value="ac_ac_CoA_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ACAS_N" evidence="2">
        <location>
            <begin position="42"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding" evidence="1">
        <location>
            <begin position="108"/>
            <end position="529"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF16177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN07394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="658" mass="72486" checksum="A8FC42B91E40ED24" modified="2018-04-25" version="1">MPSAANPTPLWKPDKEFIAEAQITRFQAWASEHYGAPADGGYEALHRWSVTELDTFWKAVADWFDIRFTTPYARVLGDRSMPGAEWFPGATLNYAEHALRTATDPERADSPAILHVDETQEPRPVTWAELRRQVGSLAAELRAIGVRPGDRVSGYLPNIPEAVVALLATAAVGGVWTSCAPDFGARSVLDRFQQVEPVVLFTVDGYRYGGKEHDRRDTVGELRAELPTLRAVVHIPLLGTDAPEGALEWSELTSADTEPVFEAVPFDHPLWVLYSSGTTGLPKAIVQSQGGILIEHLKQLGLHCDLGPGDRFFWYTSTGWMMWNFLASGLLTGTTIVVYDGSPGYPDTGAQWAVAERTGATLFGTSAAYVMACRKADVHPSRDHDLSRVKCVATTGSPLPPDGFRWLHDEVREDLWIASVSGGTDVCSCFAGAVPTLPVHIGELQAPCLGTDLQSWDPQGKPLIDEVGELVVTNPMPSMPIRFWNDPDGSRYHDSYFDTYPGVWRHGDWITLTSRGSVVIHGRADSTLNRQGVRMGSADIYEAVERLPEIRESLVIGLEQPDGGYWMPLFVHLAPGAVLDDDLRARIKQTIRENLSPRHIPDDIIEAPGVPHTLTGKRIEVPVKRLLQGTPLEKAVNLGSVDSVELLRFYEEIARNRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JKJ9</accession>
    <name>A0A2M9JKJ9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">NUDIX hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_34660</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000021">
        <property type="protein sequence ID" value="PJN07392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN07392">
        <property type="protein sequence ID" value="PJN07392"/>
        <property type="gene ID" value="CG723_34660"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020084">
        <property type="entry name" value="NUDIX_hydrolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="SSF55811"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00893">
        <property type="entry name" value="NUDIX_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="2">
        <location>
            <begin position="45"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN07392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="177" mass="19058" checksum="DDC850554A067EB1" modified="2018-04-25" version="1">MSAPHHITNAVPDSHCSSCGTAYGPDVSGWPRTCPACADVSYRNPLPVAVALQAVYDSRGSALVVITRTIAPARGGVALPGGFVDHREDWKDAVVRELKEETGIEAASRDVRLADAMSSPDGHLLLFGLLPERPAAELPEPAVTDETEGWHLLRRPAELAFPLHTLAARAWFEGRYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JKY9</accession>
    <name>A0A2M9JKY9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DNA primase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CG723_32735</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000019">
        <property type="protein sequence ID" value="PJN07539.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN07539">
        <property type="protein sequence ID" value="PJN07539"/>
        <property type="gene ID" value="CG723_32735"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015330">
        <property type="entry name" value="DNA_primase/pol_bifunc_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014820">
        <property type="entry name" value="PriCT_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09250">
        <property type="entry name" value="Prim-Pol"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00942">
        <property type="entry name" value="PriCT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00943">
        <property type="entry name" value="Prim-Pol"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Prim-Pol" evidence="3">
        <location>
            <begin position="19"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="domain" description="PriCT_1" evidence="2">
        <location>
            <begin position="227"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="39"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="39"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PJN07539.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="294" mass="30676" checksum="0EC6B5744C4D61E9" modified="2018-04-25" version="1">MATTDRHAVPFATLALAHALSAAERGLAVIPLSRTKLPALRSPHRDEPDPAPCHGECGRPGHGVYDATTDPGRIRELFAAAPRATGYGIACGLPPHHLIGVDLDTKSGTDSSAALRELALRHLFTIPDTVVVATPSGGRHVWLSGPPDVVVPNSAGRLAPGIDIRGAGGYLVGPGSRTAQGVYSAVPGTAHLPVAPCPPALLRLLTPPPRVHHPSPAHAGQHGQGLVQFVLAAHEGQRNTRLFWAACRAYESDLGDSLTNALVKAATRTGLTEHEARSTIASAARMTQRNDTEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JKZ7</accession>
    <name>A0A2M9JKZ7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Peptide ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CG723_33655</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CB01635</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000020">
        <property type="protein sequence ID" value="PJN07447.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN07447">
        <property type="protein sequence ID" value="PJN07447"/>
        <property type="gene ID" value="CG723_33655"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="34"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="97"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="131"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="262"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="93"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PJN07447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="291" mass="30481" checksum="CBCE366AD6603C3C" modified="2018-04-25" version="1">MTSIAADGKGHSRPARRIDPTLARYLSALRTPKGLTGGVVLAVLALAALLAPVIFPGGYDQQGATALIGPSVAHPFGLDEFGRDIFVRSVYGLRIDLSLILTAVPAAAALGTLLGLTGALSERLGAATQRVLDVIIGFPGLILGVCLVAILGAGWFALFLTIFISGLPSAGRYARSAWLSQQDREYVLAARVLGVKRRQLLTRHVLPNALDACVVNTAVWMVVGVYIEAGLSIVGLGIQPPTPSLGVLLNNGLRFVTQSPTYVVGPALLLLLLAVAFSLLSDAFNEAVNRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JL01</accession>
    <name>A0A2M9JL01_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycerophosphodiester phosphodiesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_32760</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000019">
        <property type="protein sequence ID" value="PJN07543.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN07543">
        <property type="protein sequence ID" value="PJN07543"/>
        <property type="gene ID" value="CG723_32760"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008081">
        <property type="term" value="F:phosphoric diester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030395">
        <property type="entry name" value="GP_PDE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017946">
        <property type="entry name" value="PLC-like_Pdiesterase_TIM-brl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03009">
        <property type="entry name" value="GDPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51695">
        <property type="entry name" value="SSF51695"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51704">
        <property type="entry name" value="GP_PDE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GP-PDE" evidence="1">
        <location>
            <begin position="9"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN07543.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="271" mass="29745" checksum="EDCB3CE33A9EB3E4" modified="2018-04-25" version="1">MTLARQQQIQVVAHRGASDEAPEHTLAAYRRAIQDGADALECDVRLTADGHLVCVHDRRVNRTSNGRGAVSALELADLAALDFGSWKNSEAGRTSTEGPDWEDTSVLTLERLLELVADAGRRVELAIETKHPTRWAGQVEERLLMLLKRFGLDAPTGAPDTPSPVRVMSFSARSLHRVQVASPHLPTVYLMQFVSPRHRDGRLPKGVSIAGPGIRIVRSHPGYVEKLKRAGHQVHVWTVNEPEDVDLCVGLGVDAIITNRPRAVLRQLGRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JLI1</accession>
    <name>A0A2M9JLI1_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Acetylornithine aminotransferase</fullName>
            <shortName evidence="2">ACOAT</shortName>
            <ecNumber evidence="2">2.6.1.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">argD</name>
        <name evidence="4" type="ORF">CG723_32230</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CB01635</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>2-oxoglutarate + N(2)-acetyl-L-ornithine = L-glutamate + N-acetyl-L-glutamate 5-semialdehyde</text>
            <dbReference type="Rhea" id="RHEA:18049"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29123"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57805"/>
            <dbReference type="EC" id="2.6.1.11"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
        <text evidence="2">Binds 1 pyridoxal phosphate per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-arginine biosynthesis; N(2)-acetyl-L-ornithine from L-glutamate: step 4/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="miscellaneous">
        <text evidence="2">May also have succinyldiaminopimelate aminotransferase activity, thus carrying out the corresponding step in lysine biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. ArgD subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.11" evidence="2"/>
    <dbReference type="EMBL" id="NNBL01000018">
        <property type="protein sequence ID" value="PJN07740.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN07740">
        <property type="protein sequence ID" value="PJN07740"/>
        <property type="gene ID" value="CG723_32230"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00068">
        <property type="reaction ID" value="UER00109"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003992">
        <property type="term" value="F:N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006526">
        <property type="term" value="P:arginine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00610">
        <property type="entry name" value="OAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01107">
        <property type="entry name" value="ArgD_aminotrans_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004636">
        <property type="entry name" value="AcOrn/SuccOrn_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005814">
        <property type="entry name" value="Aminotrans_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00202">
        <property type="entry name" value="Aminotran_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000521">
        <property type="entry name" value="Transaminase_4ab_Lys_Orn"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00707">
        <property type="entry name" value="argD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00600">
        <property type="entry name" value="AA_TRANSFER_CLASS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="2 4" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="2" id="KW-0055">Arginine biosynthesis</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 2 3" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Pyridoxal phosphate binding" evidence="2">
        <location>
            <begin position="106"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Pyridoxal phosphate binding" evidence="2">
        <location>
            <begin position="217"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="132"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="135"/>
        </location>
        <ligand>
            <name>N(2)-acetyl-L-ornithine</name>
            <dbReference type="ChEBI" id="CHEBI:57805"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="275"/>
        </location>
        <ligand>
            <name>N(2)-acetyl-L-ornithine</name>
            <dbReference type="ChEBI" id="CHEBI:57805"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="276"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="2">
        <location>
            <position position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PJN07740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="400" mass="41567" checksum="C03D7054A5650701" modified="2018-04-25" version="1">MSNQELTARWQGALMDNYGTPRLPLVRGAGAKVWDADGKEYVDFVGGIAVNALGHAHPAVVRAVTEQIASLGHVSNLFVAEPPVALAERLLQLFGRSGRVYFCNSGAEANEGAFKIGRLTGRSHMVATQGGFHGRTMGSLALTGQPGKQEPFVPLPGDVTHVPYGDAEALRAAVTEETALVIIEPIQGENGVVVPPAGYLRVAREITRATGTLLVLDEVQTGIGRTGHWFAYQAEEGIDPDVVTLAKGLGGGLPIGATVAFGEAAELLKPGHHGTTFGGNPVACAAGLAVLDTVAGEGLLENVKRAEARLRDGIASLGHPLVGHVRGAGLLLGIVLTEPRAPQVQQAAQDAGLLVNAPAPDVVRLMPPLNLRDDEVDTFLQALPGVLDKALEGADGEGRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JLR4</accession>
    <name>A0A2M9JLR4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_30970</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000017">
        <property type="protein sequence ID" value="PJN07831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN07831">
        <property type="protein sequence ID" value="PJN07831"/>
        <property type="gene ID" value="CG723_30970"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="16"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN07831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="292" mass="33418" checksum="CEF4CA3B32CEB589" modified="2018-04-25" version="1">MQLVKWIPPVEAKLNLWQIAAIFVACISLYNILRGWWRSTLGRRGFFVRNCRKLAPHVRHEYVKGLFGEPAWQHKQNVEQYSSEQEVPGSTETLEMTVRTWPLGRMGFLVTWCTANDEVEMYSITTRSRIFRPAIRVGGRYLVRLGKSRLSALPYPDVIEDPIQWRIGSRRFSYAETHYFGNPGAYHTWAMGVSDSGHPAAPPVELGSSPEYCNDPVEIPRYRARARINSVLVAGGSAIRLNSLLPDGVGPDHDRVRLADPEYGLRALCTRLRWQTWQAASHMRELVRRGEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JM31</accession>
    <name>A0A2M9JM31_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alkanesulfonate monooxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_31540</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000017">
        <property type="protein sequence ID" value="PJN07912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN07912">
        <property type="protein sequence ID" value="PJN07912"/>
        <property type="gene ID" value="CG723_31540"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011251">
        <property type="entry name" value="Luciferase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036661">
        <property type="entry name" value="Luciferase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00296">
        <property type="entry name" value="Bac_luciferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51679">
        <property type="entry name" value="SSF51679"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bac_luciferase" evidence="1">
        <location>
            <begin position="18"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN07912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="366" mass="39725" checksum="5061239DB1CBFDEC" modified="2018-04-25" version="1">MPVEFISAVHTDSGASGPAASARTGFDPDYVRRYARALDDGGFDHTLVAYHSASPDALQLAQFVATHTERIRPVLAHRPGVIFPTHAARAFATLDRISNGRLSVHIISGGSDEEQHREGDYLNKAERYERSDEYIQILRKVWTAGGPVSHEGKHYKFEGFHSDVRPANGLVPISVGGSSQDAYRVGGQQGDIFGLWGEPLKETAEQIAAVNAVADAAGRPRPRIWVSFRPIIAPTDELAWEKAHRTLGVLQEQAAGTELLRHYRTTGRPANVGSQRLLDIAERGEVHDRCLWTAPAAATNAAGASTALVGSPETVAKALLDYVDIGCDLLSIRGYDPLNDAIDYARYILPLVRQELAHRAATSQAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JM47</accession>
    <name>A0A2M9JM47_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_31680</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000017">
        <property type="protein sequence ID" value="PJN07932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN07932">
        <property type="protein sequence ID" value="PJN07932"/>
        <property type="gene ID" value="CG723_31680"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045513">
        <property type="entry name" value="DUF6479"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20087">
        <property type="entry name" value="DUF6479"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="31"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN07932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="73" mass="7732" checksum="EA16ADD3B58D139D" modified="2018-04-25" version="1">MAVEGGSSLLFLIVGIIVVLGLLAMFVSGRRRAARRTEPSTPAPGTAPGSEEAQHGTTWQTPDDDPEQGHPHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JMF1</accession>
    <name>A0A2M9JMF1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_30660</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000016">
        <property type="protein sequence ID" value="PJN08046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08046">
        <property type="protein sequence ID" value="PJN08046"/>
        <property type="gene ID" value="CG723_30660"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014825391" evidence="2">
        <location>
            <begin position="18"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN08046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="64" mass="6650" checksum="B5828BB3EB6FF831" modified="2018-04-25" version="1">MVTLTVSGSLTARMVLMVTASTGGMVLTSPSVLSDAVLAYVAVRATRRRTAQLRPGPTAATEAW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JMM5</accession>
    <name>A0A2M9JMM5_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF2154 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_29375</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000015">
        <property type="protein sequence ID" value="PJN08120.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08120">
        <property type="protein sequence ID" value="PJN08120"/>
        <property type="gene ID" value="CG723_29375"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012551">
        <property type="entry name" value="DUF1707"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024425">
        <property type="entry name" value="DUF2154"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08044">
        <property type="entry name" value="DUF1707"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09922">
        <property type="entry name" value="DUF2154"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF2154" evidence="2">
        <location>
            <begin position="109"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN08120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="222" mass="24439" checksum="398736B041D8C137" modified="2018-04-25" version="1">MDLEKRSEQPAPQTDLRASDADRDRTAEILREALAEGRLTAEEHSERIDGVYRAKTHAELEPLVRDLPGAHTQHRPTTSSPAPNRPAMGAVPAVADENLVAVFSTSARKGRWRVGRRTHAYAIFGNIEIDLSEAIFEYQQVVIKAVSVFGNVEVRVPENISLRGSGGGVLGNFEVHTLDSADPDAPVVYVDGIAVLGNIEAKPKRGKRLRDLHDRMRKHLDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-09-29" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JMS0</accession>
    <name>A0A2M9JMS0_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SPOR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_29560</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000015">
        <property type="protein sequence ID" value="PJN08155.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08155">
        <property type="protein sequence ID" value="PJN08155"/>
        <property type="gene ID" value="CG723_29560"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042834">
        <property type="term" value="F:peptidoglycan binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1070">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007730">
        <property type="entry name" value="SPOR-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036680">
        <property type="entry name" value="SPOR-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05036">
        <property type="entry name" value="SPOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SPOR" evidence="1">
        <location>
            <begin position="9"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN08155.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="63" mass="7264" checksum="045E19E95CB4E67B" modified="2018-04-25" version="1">MNEGTTTLVWLVIRQDDNGNRYRVGRYATRAEAQQIADSLDDRGHKQLYWVERLGQAQNGTAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JNA0</accession>
    <name>A0A2M9JNA0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DUF5063 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CG723_28545</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000014">
        <property type="protein sequence ID" value="PJN08339.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08339">
        <property type="protein sequence ID" value="PJN08339"/>
        <property type="gene ID" value="CG723_28545"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1550">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032025">
        <property type="entry name" value="DUF5063"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038312">
        <property type="entry name" value="DUF5063_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16702">
        <property type="entry name" value="DUF5063"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PJN08339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="219" mass="24009" checksum="5207C136C298D596" modified="2018-04-25" version="1">MSDATLNAVKDDPDDFAVQISDQIESFLVAVAEVAKGDEPDSAVPFLLLELSQLLFAGGRLGAHEDIVPDERYEPDLGPEPDVDDLRQKLATILEPIDVYSEVFDPYEPRKAPVACRISDDLADVMADLRHGMAHYRAGRTTEALWWWQFSYFSNWGSTASGALRALQSLVAHVRLNQPLDDLDGLDTDEDLAEEALAEAAGKVMAEEIAGPLGLRTVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JND0</accession>
    <name>A0A2M9JND0_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PPM-type phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_28470</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000014">
        <property type="protein sequence ID" value="PJN08327.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08327">
        <property type="protein sequence ID" value="PJN08327"/>
        <property type="gene ID" value="CG723_28470"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07228">
        <property type="entry name" value="SpoIIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="SSF81606"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPM-type phosphatase" evidence="1">
        <location>
            <begin position="50"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN08327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="186" mass="20438" checksum="60FAAFA5F48FAD7B" modified="2018-04-25" version="1">MATSSHHERRSHIAMSRQSLLFIDAGFYRPLRVRYGNFRHSTGRWSGGGSEVTFLNFGHPAPMLVRPDGSAHFPRPPQYALPLGLGVHGAEGPEPYTVGFEPGDQILLYTDGVTEARDRAGDFYPLGDRASLLKDPDPEAALRELRADLVHHAAGPLHDDAAMLLLRHRHEEPPGTVPPFVPSAPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JP89</accession>
    <name>A0A2M9JP89_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_26675</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000012">
        <property type="protein sequence ID" value="PJN08684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08684">
        <property type="protein sequence ID" value="PJN08684"/>
        <property type="gene ID" value="CG723_26675"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043917">
        <property type="entry name" value="DUF5753"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19054">
        <property type="entry name" value="DUF5753"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="20"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN08684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="280" mass="31710" checksum="97A7137C35063C9D" modified="2018-04-25" version="1">MSSRKDPDASANVPSFYGAELRFKRELAELTLEQLAEGSFRGVPFLSQIERGERRMPLDLARHVDEKLGTDGFFQRRCEDARKARQSGHAEYFADVAEMEQHAETIEDWAPMIVPGLLQTEEYATAVVHTSLPWLRPETVDKQVGARMKRAKLWEREDHPTFWGIVRESMIRNPLLPPGEMAEQLGHIVRLVRSTQSVLQVLPETAAAHPMMMGMIRVMTFPDAPPVVYTEGLHSGQLIDYPALVKDYRRSYDLLRAAALPPEASLALIEEAAEDYRNGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JPA7</accession>
    <name>A0A2M9JPA7_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CG723_26625</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CB01635</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="NNBL01000012">
        <property type="protein sequence ID" value="PJN08675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08675">
        <property type="protein sequence ID" value="PJN08675"/>
        <property type="gene ID" value="CG723_26625"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025666">
        <property type="entry name" value="PQQ-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018391">
        <property type="entry name" value="PQQ_beta_propeller_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002372">
        <property type="entry name" value="PQQ_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_supfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13360">
        <property type="entry name" value="PQQ_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13570">
        <property type="entry name" value="PQQ_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00564">
        <property type="entry name" value="PQQ"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="SSF50998"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="8">
        <location>
            <begin position="16"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="292"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="325"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="44"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PJN08675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="801" mass="83941" checksum="560E937B91A514A9" modified="2018-04-25" version="1">MVDQLTQHDPRRIGPFEVLGRLGAGGMGLVYLARSASGRRVAIKTVRTELAEDQLFRVRFTREVEAARAVSGFYTAAVVDADPRAAVPWLATAYVPAPSLEEIVNECGPLPAQAVRWLAAGIAEALQSIHGAGLVHRDLKPSNVLVVEDGPRVIDFGIASGVSNTRLTMTNVAVGTPAYMSPEQAKDSRSVTGASDVFSLGSTLVFAATGHAPFHGANPVETVFMLLREGPDIEGLPTELRPLIESCMKMEAPLRPSPADLQAQLAPHLFGSGSDDSGTASAWLPERSVALIEERRGGRPPVKSSGPGRGGSGGRGVHGGAPGPMPAMPAQPPGPPPSHAPGTGGWRPAPAPVGTSGLAPDAGPVRLAGAQVPIGPGPRVADARAAAVKAPPADAGLAASWSRPKPGVNGAPDPVIPAPAPEAGAAWRPWRFRMSNDVWGTPSVAGDLVYVTSFEVHALDVSTGRRRFKTRDVAWSMAVADGRIHASDGPTLYALDAREGHDLWRLQTDAWVYSLKADRGTVVTGTRGGGVQAWEAVNGDKLWEITGAQTDFESPEAGPVIHDGTVYVWKDARLRALEARTGEERWSYPIGDAASCGGVPVRLTQASDGYVYVAAGTRVLAVDVASGHVRWHFEAPAVFLCPPAFAPGPAVTGGGVYLADHLGTVYALDATDGRDRWRIATEPRPSSIEPVLVSHGHVHVGSGQGLYTLDAVTGTPKWRFQAGGEVVGSPVVADNRIHFGATDHLLYTLKADDGRLRWKLATGGEITGAPVVKDGVVYACSKDRCVYALDAEKGTGTASAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JPF6</accession>
    <name>A0A2M9JPF6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Cyclohexanone monooxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CG723_27095</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CB01635</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FAD-binding monooxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000012">
        <property type="protein sequence ID" value="PJN08750.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08750">
        <property type="protein sequence ID" value="PJN08750"/>
        <property type="gene ID" value="CG723_27095"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004499">
        <property type="term" value="F:N,N-dimethylaniline monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020946">
        <property type="entry name" value="Flavin_mOase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00743">
        <property type="entry name" value="FMO-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="497"/>
            <end position="517"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PJN08750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="517" mass="57048" checksum="CB357922AE838EE5" modified="2018-04-25" version="1">MTEHEHEHVRVVVIGSGFGGLGAAVRLRREGVTDFVVLERADAVGGTWRDNSYPGCACDVPSHLYSFSFAPNPDWPRTFSGQERIREYLEGVADTFRLRPHIRFDHEVKQARWDTEKLWWVVETSQGTLTADVVVSATGPLSDPKMPDIKGLDAFPGKVFHSARWDHDYDLRGKRVAVIGTGASAIQIVPAIQRDVAKLTLFQRTPPWVMPRADRAITGAERWLHRRLPFTTQARRGLLWGIRELQVQAFTKRPNELGLVEQLAKRNIHRSIKDPALRAKLTPNYRIGCKRILLSNAYYPALAQPNVDVVASGLSEIRGSTLVATDGSEVEVDAIVFSTGFHVTDMPIADRVVGAEGHTLMESWKDGMKALRGATAAGFPNFMTVIGPNTGLGNSSMILMIESQLNYLADYVRQLDVLGGRVALDPRASAVNAWNRRVQDRMERTVWSSGGCSSWYLDESGVNTTLWPGTTTEFRSATRRVDLGEYEVVRAPAAKPAAVPAARTKKGRGGKVEAGAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JPH1</accession>
    <name>A0A2M9JPH1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_26690</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000012">
        <property type="protein sequence ID" value="PJN08687.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08687">
        <property type="protein sequence ID" value="PJN08687"/>
        <property type="gene ID" value="CG723_26690"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022074">
        <property type="entry name" value="DUF3626"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12294">
        <property type="entry name" value="DUF3626"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN08687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="296" mass="32309" checksum="86E32299721D4D13" modified="2018-04-25" version="1">MSAEASRTPQERALRHVASVASGPPVDSSLRVTLNFHPDRLLHGKPILDALADDGVYRSQFVTGTSNGGLTAYPGGDRWRWESRIFDASYDEAPAQDRPVYGALNFRRKAMGGAPRFGSAHFRLTAEAVARTTFCYPDSFLEPSDFGVADRMGLIGLALADSKDDLDDYIEAQVHGAVRPDCHVEALVLDPCYRGTPVEAAALRLGCPVEWHGGFRLGVEELRRHPDYRGQEYVDLGTRIAVGGVLDPGIIGDAARADRYDPQSVKRVWHYLARFGAGTTTGPSRAGSRAARMRPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-05-25" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JPI6</accession>
    <name>A0A2M9JPI6_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1 2">Peptidyl-tRNA hydrolase</fullName>
            <shortName evidence="1">PTH</shortName>
            <ecNumber evidence="1 2">3.1.1.29</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">pth</name>
        <name evidence="4" type="ORF">CG723_27315</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CB01635</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 2">
            <text>an N-acyl-L-alpha-aminoacyl-tRNA + H2O = a tRNA + an N-acyl-L-amino acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:54448"/>
            <dbReference type="Rhea" id="RHEA-COMP:10123"/>
            <dbReference type="Rhea" id="RHEA-COMP:13883"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:59874"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:138191"/>
            <dbReference type="EC" id="3.1.1.29"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the PTH family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.29" evidence="1 2"/>
    <dbReference type="EMBL" id="NNBL01000012">
        <property type="protein sequence ID" value="PJN08788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08788">
        <property type="protein sequence ID" value="PJN08788"/>
        <property type="gene ID" value="CG723_27315"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004045">
        <property type="term" value="F:aminoacyl-tRNA hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00462">
        <property type="entry name" value="PTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1470">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00083">
        <property type="entry name" value="Pept_tRNA_hydro_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001328">
        <property type="entry name" value="Pept_tRNA_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018171">
        <property type="entry name" value="Pept_tRNA_hydro_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036416">
        <property type="entry name" value="Pept_tRNA_hydro_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17224">
        <property type="entry name" value="PTHR17224"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01195">
        <property type="entry name" value="Pept_tRNA_hydro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53178">
        <property type="entry name" value="SSF53178"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00447">
        <property type="entry name" value="pth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01195">
        <property type="entry name" value="PEPT_TRNA_HYDROL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01196">
        <property type="entry name" value="PEPT_TRNA_HYDROL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU000673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU004320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PJN08788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="198" mass="21450" checksum="7D8B91EB16C67ED4" modified="2018-04-25" version="1">MTTDATAPWLIVGLGNPGPEYAMNRHNVGFMVADLLAERIGGKFKRAGKAQAQVLEGRIGAPGPQNRRVILAKPMSFMNVSGGPVTGLRDFYKVPVGNTVAIHDELDIDYGTMRLKLGGGDNGHNGLKSITKSMGADYHRVRFGIGRPPGRMQVADFVLKDFSSTERKELDYLVDRAADAVECLVTEGLERAQSAYNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JPQ1</accession>
    <name>A0A2M9JPQ1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_25385</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000011">
        <property type="protein sequence ID" value="PJN08836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08836">
        <property type="protein sequence ID" value="PJN08836"/>
        <property type="gene ID" value="CG723_25385"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="42"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN08836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="229" mass="24985" checksum="F3247CCCCDBD6A69" modified="2018-04-25" version="1">MHPSDSAPPFNAPAARRLREALGMAPGHVAYGMRASYGQHQVTPDTIIAWERGLASPTAVEITALAGALWCSPGDLIGAARTLREHRMARGMAPEDVARTVGVEIHSYLRMEETGEWRGNERQSATLAEVLGLTPPDFATVTGRNDQLADLLRSAVTTRWQAYTRPIAKLVPVHKGQLEEVLQEMQLEYQALMAATLSWGGGSGRESGEAGRELLDGILDEFWSRMHTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JQ18</accession>
    <name>A0A2M9JQ18_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Diacylglycerol kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_26160</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000011">
        <property type="protein sequence ID" value="PJN08969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08969">
        <property type="protein sequence ID" value="PJN08969"/>
        <property type="gene ID" value="CG723_26160"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003951">
        <property type="term" value="F:NAD+ kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017438">
        <property type="entry name" value="ATP-NAD_kinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001206">
        <property type="entry name" value="Diacylglycerol_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016064">
        <property type="entry name" value="NAD/diacylglycerol_kinase_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00781">
        <property type="entry name" value="DAGK_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00046">
        <property type="entry name" value="DAGKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111331">
        <property type="entry name" value="SSF111331"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50146">
        <property type="entry name" value="DAGK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DAGKc" evidence="1">
        <location>
            <begin position="1"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN08969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="322" mass="34550" checksum="CBA63A44C476084C" modified="2018-04-25" version="1">MRALLVVNPAATTTSARTRDVLIHALASEMKLEAITTEYRGHARDLGRQAAESKDIELVVALGGDGTVNEVVNGLLHHGPNPDRLPRLAVVPGGSTNVFARALGLPNDAVEATGALLDALREGRERTVGLGLAGGTPGTEDEAAPSRWFTFCAGLGFDGGVIGRVEQQRERGKRSTHALYLRQVVRQFLGEHDRRHGAITLDRPGENPVTDLVLSIVCNTSPWSYLGNKPLYASPRASFDTGLDVLGLKKLSTPSVARYGTQLLTSTPDRGPHGKNAVTLHDLTDFTLQSKVPLPLQMDGDHLGLRTSVTFTGVRRALRVIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JQ82</accession>
    <name>A0A2M9JQ82_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Multidrug ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CG723_24170</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000010">
        <property type="protein sequence ID" value="PJN09034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN09034">
        <property type="protein sequence ID" value="PJN09034"/>
        <property type="gene ID" value="CG723_24170"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="3"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="35"/>
            <end position="42"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PJN09034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="309" mass="32305" checksum="B5B793927F9AE9F3" modified="2018-04-25" version="1">MTIRAHGLTKRYGDKTVVQDLTFTVNPGTVTGFLGPNGAGKSTTMRMLLGLDAPTSGRATVGGRAYAAHAAPLHEVGALLEARSIHPGRTAFHHLMALAHTHGVPRSRVDHVLALTGLTEVAGKRVKGFSLGMGQRLGIAAALIADPATVILDEPVNGLDPEGVLWVRNLLKSLAAEGRTVLVSSHLMSETALTADHLIIIGRGRLLADTTVSELVRESGAAYVKVVTPEAVRLRELLSGAPGVDVTGESPDTLHVRGTDAPDIGRTAATHGIPLFELTPQTASLEQAFMDLTHDSVEYQATALTGAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JQM3</accession>
    <name>A0A2M9JQM3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DUF397 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_25005</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000010">
        <property type="protein sequence ID" value="PJN09172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN09172">
        <property type="protein sequence ID" value="PJN09172"/>
        <property type="gene ID" value="CG723_25005"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007278">
        <property type="entry name" value="DUF397"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04149">
        <property type="entry name" value="DUF397"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF397" evidence="2">
        <location>
            <begin position="13"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN09172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="69" mass="7619" checksum="0D60EB0DA9289822" modified="2018-04-25" version="1">MKITHPEPDLTSATWHKSSYSGGQGGDCLEVTHDHPGLVPVRDSKSPDGPKLVLRAEAWTAFIDDLRRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JQN4</accession>
    <name>A0A2M9JQN4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CG723_25070</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000010">
        <property type="protein sequence ID" value="PJN09184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN09184">
        <property type="protein sequence ID" value="PJN09184"/>
        <property type="gene ID" value="CG723_25070"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009218">
        <property type="entry name" value="HD_phosphohydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21174">
        <property type="entry name" value="PTHR21174"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF035170">
        <property type="entry name" value="HD_phosphohydro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PJN09184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="216" mass="24144" checksum="92BC9EE2308209C1" modified="2018-04-25" version="1">MRDDLRKAWAETLATAQHATATPTTPDAYADNLLARWSEPQRRYHTTTHLKAVLDHIDVLEDHADDPALVRLAAWFHDAVYLPERSTNEERSARLAERALSEAGLTDQQIDEVSRLVLLTVTHDPDEDDHNGEVLCDADLAILAAAPDAYAAYAAAVREEYGFVPDEPFREGRAAVLQQLLALPRLFRTPYGAAHWEERARENLTAELDLLTPQTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JQY0</accession>
    <name>A0A2M9JQY0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Acyl-CoA dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CG723_23325</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CB01635</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000009">
        <property type="protein sequence ID" value="PJN09286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN09286">
        <property type="protein sequence ID" value="PJN09286"/>
        <property type="gene ID" value="CG723_23325"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016627">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="SSF47203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="SSF56645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0274">FAD</keyword>
    <keyword evidence="3 5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA_dh_N" evidence="8">
        <location>
            <begin position="6"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_M" evidence="7">
        <location>
            <begin position="141"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_1" evidence="6">
        <location>
            <begin position="247"/>
            <end position="392"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PJN09286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="400" mass="44005" checksum="4598A38EB84AB9F0" modified="2018-04-25" version="1">MSGIPEPEEFRAEARQWLATVARPRAADGAWGSGSDSVAVFENWTEEQEREHTARTQEWERTRYDRGWGALNWQAAYGGRDLPAYYEQLYRSEEAAFDVPHRTEIFPVTQQLVASAIGIWGTEEQKARWLRPMLRTDELACQLFSETEAGSDLAAVRTKAVRDGDHWVLDGHKVWTSGARVATWGVAVCRTDPDVRKHAGITVFLVRMDAPGVTVRPIQQMTGGASFNEVYLDGVVVPDTDRLGPVGEGWRVTLSVLAAERLDSGNLGLDNADHALDLARNLPRPLTGAEQQRATDLYVRALVQRLIGLRITGALVAGREPGAEASVGKLYATETMRRTSDLVAELLGPSLVADTGEWGTYAWTEHLLGAPGYSIAGGTDEIQHNILAERVLGLPKEPVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JR00</accession>
    <name>A0A2M9JR00_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Acyl-CoA dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CG723_23370</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CB01635</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000009">
        <property type="protein sequence ID" value="PJN09295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN09295">
        <property type="protein sequence ID" value="PJN09295"/>
        <property type="gene ID" value="CG723_23370"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016627">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="SSF47203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="SSF56645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA_dh_N" evidence="4">
        <location>
            <begin position="16"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_1" evidence="3">
        <location>
            <begin position="226"/>
            <end position="367"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PJN09295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="377" mass="39816" checksum="576819F22A4C22ED" modified="2018-04-25" version="1">MHSRHPEIDPQSLSETDEQRELRTVLRDFFTETSGPEDVRKQLATPRGHDEALWARLAGEIGVHGLAIPEEYGGSGFTFAELAVALQESGRALYCAPLLPTVVLAAHALLHSGDRQACARHLPRIADGTLTATVAGFDDTEPGIGAEHGTSGWVLRGAADFVLDGAGADLIVVRAQTPDGARLFSCEPTADTCVRTPHRVLDETRRQARVEFRGAPATPVGNSGEVTATLDAGRAALAAEQVGGSGHALDATVEFVAQRRQFGRPIGSFQAVKHRLADVLVALEAARSASSYATVCVATASPQLPVAASAAAAVCSETFRLATAEYVQLHGGIGFTWEHPAHLYVRRARSGEALFGTADQNRARLAELVGLAPRSAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JRT1</accession>
    <name>A0A2M9JRT1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Glycoside hydrolase 43 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CG723_22780</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CB01635</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the glycosyl hydrolase 43 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000008">
        <property type="protein sequence ID" value="PJN09564.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN09564">
        <property type="protein sequence ID" value="PJN09564"/>
        <property type="gene ID" value="CG723_22780"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.115.10.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041542">
        <property type="entry name" value="GH43_C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006710">
        <property type="entry name" value="Glyco_hydro_43"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023296">
        <property type="entry name" value="Glyco_hydro_beta-prop_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17851">
        <property type="entry name" value="GH43_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04616">
        <property type="entry name" value="Glyco_hydro_43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="SSF49899"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75005">
        <property type="entry name" value="SSF75005"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 6 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GH43_C2" evidence="7">
        <location>
            <begin position="297"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="4">
        <location>
            <position position="14"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="4">
        <location>
            <position position="171"/>
        </location>
    </feature>
    <feature type="site" description="Important for catalytic activity, responsible for pKa modulation of the active site Glu and correct orientation of both the proton donor and substrate" evidence="5">
        <location>
            <position position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR606710-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR606710-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF17851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PJN09564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="492" mass="52906" checksum="4C252D8A5F751CD4" modified="2018-04-25" version="1">MADPRPAIPGFHPDPSVCRVGDDYYLACSSFEYVPGVPLFHSRDLVRWRQIGNILDRPGQLRLPWDTPSSAGIYAPTLRHHGGRFWLITTNVSEGGGNLLVSATDPAGPWSDPVPLPGVPGIDPDLAWDEDDACWVTVAGISQVRIDPYTGEMFGEPRPLWSGTPGAKAPEAPHLYHVGDHWYLLISEGGTERGHAVSVARGPAPTGPFEPCPANPVLTHRGTDEPVQNTGHADLVQAPDGTWWMVFLGVRPRGGTPGWHVLGRETFLAPVTWEDGWPVVGPPATAGPAPASAEPFTDDFDDADLQPSWISLRHRSPRHCTTKERPGRLTLHALGGGPDAADVTFVGHRQQHLSCRVRAHLDPADGTGGLVVRLDERHHYEIEADAVEVRVIARVGPLRTVVASTSRATAGEPLVLGVDMTPTDTPGDARTGPDMLAFGVEDPHGTFTALAALDGRYLSTEVAGGFTGRVIGLYAATGTAHFDWFRYEPLAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JS15</accession>
    <name>A0A2M9JS15_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Agmatine deiminase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_20865</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000007">
        <property type="protein sequence ID" value="PJN09666.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN09666">
        <property type="protein sequence ID" value="PJN09666"/>
        <property type="gene ID" value="CG723_20865"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004668">
        <property type="term" value="F:protein-arginine deiminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009446">
        <property type="term" value="P:putrescine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007466">
        <property type="entry name" value="Peptidyl-Arg-deiminase_porph"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31377">
        <property type="entry name" value="PTHR31377"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04371">
        <property type="entry name" value="PAD_porph"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN09666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="342" mass="37416" checksum="36D68569E1920970" modified="2018-04-25" version="1">MSSFHMPPEWAPHERTWMAWPSPNPTFTNDEELAEAREAWASVARAVRRFEPVTVIVAPGQSDSARALLGDDIELVERDLDDAWMRDIGPTFVVGDGRLAAVDWTFNGWGAQDWAVWEHDAKIARHIADLAGVPVHSSSLVNEGGGIHVDGEGTVLLTETVQLDPDRNPGRTKAEVEQEIHARIGTTKAIWLPRGLTGDYGVYGTRGHVDIVAAFAAPGVVLVHSQQDPAHPDHELSKQLIAQLRGETDAKGRPLEVVEVPAPTVLKDDEGWVDYSYINHYLCNDGVVLCSFDDPNDEVAAGIFRRLFPGRTVQLVDARTIFAGGGGIHCITQQQPETTPAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JS32</accession>
    <name>A0A2M9JS32_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Branched-chain-amino-acid aminotransferase</fullName>
            <ecNumber evidence="15">2.6.1.42</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">CG723_20845</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">CB01635</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 15">
            <text>2-oxoglutarate + L-isoleucine = (S)-3-methyl-2-oxopentanoate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:24801"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:35146"/>
            <dbReference type="ChEBI" id="CHEBI:58045"/>
            <dbReference type="EC" id="2.6.1.42"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 15">
            <text>2-oxoglutarate + L-leucine = 4-methyl-2-oxopentanoate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:18321"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:17865"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57427"/>
            <dbReference type="EC" id="2.6.1.42"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3 15">
            <text>2-oxoglutarate + L-valine = 3-methyl-2-oxobutanoate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:24813"/>
            <dbReference type="ChEBI" id="CHEBI:11851"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57762"/>
            <dbReference type="EC" id="2.6.1.42"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4 14">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="5 16">Amino-acid biosynthesis; L-isoleucine biosynthesis; L-isoleucine from 2-oxobutanoate: step 4/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="7 16">Amino-acid biosynthesis; L-leucine biosynthesis; L-leucine from 3-methyl-2-oxobutanoate: step 4/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="6 16">Amino-acid biosynthesis; L-valine biosynthesis; L-valine from pyruvate: step 4/4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8 13">Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.42" evidence="15"/>
    <dbReference type="EMBL" id="NNBL01000007">
        <property type="protein sequence ID" value="PJN09662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN09662">
        <property type="protein sequence ID" value="PJN09662"/>
        <property type="gene ID" value="CG723_20845"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00047">
        <property type="reaction ID" value="UER00058"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00048">
        <property type="reaction ID" value="UER00073"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00049">
        <property type="reaction ID" value="UER00062"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052656">
        <property type="term" value="F:L-isoleucine transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052654">
        <property type="term" value="F:L-leucine transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050048">
        <property type="term" value="F:L-leucine:2-oxoglutarate aminotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052655">
        <property type="term" value="F:L-valine transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009097">
        <property type="term" value="P:isoleucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009098">
        <property type="term" value="P:leucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009099">
        <property type="term" value="P:valine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01557">
        <property type="entry name" value="BCAT_beta_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001544">
        <property type="entry name" value="Aminotrans_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018300">
        <property type="entry name" value="Aminotrans_IV_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036038">
        <property type="entry name" value="Aminotransferase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005786">
        <property type="entry name" value="B_amino_transII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043132">
        <property type="entry name" value="BCAT-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043131">
        <property type="entry name" value="BCAT-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033939">
        <property type="entry name" value="BCAT_family"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11825">
        <property type="entry name" value="PTHR11825"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01063">
        <property type="entry name" value="Aminotran_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006468">
        <property type="entry name" value="BCAT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56752">
        <property type="entry name" value="SSF56752"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01123">
        <property type="entry name" value="ilvE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00770">
        <property type="entry name" value="AA_TRANSFER_CLASS_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="15" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="9 15 17" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="15" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="11 14" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 15 17" id="KW-0808">Transferase</keyword>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="12">
        <location>
            <position position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000627"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00000995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00004931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00005072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00009320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR006468-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU004106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU004516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU004517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU004519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="PJN09662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="362" mass="39033" checksum="42B56743F9C6343A" modified="2018-04-25" version="1">MTTPTIELKPSSTPLSGAEREAILANPGFGRHFTDHMVTIRWTEGRGWHDGQLVPYGPLSLDPATNVLHYAQEIFEGLKAYRRPDGTVATFRPEMNAKRFQASARRLAMPELPVETFIEACDALVTQDIAWVPAHGGEESLYLRPFMIATEVGLGVKPANEYLFIVIASPAGAYFAGGVKPVSIWLSEDRVRAVPGGMGDAKTGGNYAASLLAQAEAAAEGCDQVAYLDAVEHKWVEELGGMNLYFVYGDKIVTPELTGSLLAGVTRDSLLSVARDLGYESVEGRVSIDQWQADSENGTLTEVFACGTAAVITPVGTVKRAGAQWTQSGGEPGEVTLKLREALLDIQRGTSVDKHGWMHQLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JS66</accession>
    <name>A0A2M9JS66_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Chromosome partition protein Smc</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">smc</name>
        <name evidence="9" type="ORF">CG723_21165</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CB01635</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Required for chromosome condensation and partitioning.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="5">Contains large globular domains required for ATP hydrolysis at each terminus and a third globular domain forming a flexible hinge near the middle of the molecule. These domains are separated by coiled-coil structures.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SMC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000007">
        <property type="protein sequence ID" value="PJN09715.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN09715">
        <property type="protein sequence ID" value="PJN09715"/>
        <property type="gene ID" value="CG723_21165"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030261">
        <property type="term" value="P:chromosome condensation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007062">
        <property type="term" value="P:sister chromatid cohesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01894">
        <property type="entry name" value="Smc_prok"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003395">
        <property type="entry name" value="RecF/RecN/SMC_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024704">
        <property type="entry name" value="SMC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010935">
        <property type="entry name" value="SMC_hinge"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036277">
        <property type="entry name" value="SMC_hinge_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011890">
        <property type="entry name" value="SMC_prok"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06470">
        <property type="entry name" value="SMC_hinge"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02463">
        <property type="entry name" value="SMC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005719">
        <property type="entry name" value="SMC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00968">
        <property type="entry name" value="SMC_hinge"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75553">
        <property type="entry name" value="SSF75553"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014708930" description="Chromosome partition protein Smc" evidence="7">
        <location>
            <begin position="18"/>
            <end position="1271"/>
        </location>
    </feature>
    <feature type="domain" description="SMC hinge" evidence="8">
        <location>
            <begin position="512"/>
            <end position="710"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="311"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="607"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="791"/>
            <end position="815"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="884"/>
            <end position="918"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="950"/>
            <end position="969"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1023"/>
            <end position="1056"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="167"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="241"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="825"/>
            <end position="852"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="1058"/>
            <end position="1120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="315"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1041"/>
            <end position="1056"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="32"/>
            <end position="39"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PJN09715.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="1271" mass="135383" checksum="E14632FC9CC026E2" modified="2018-04-25" version="1">MHLKALTLRGFKSFASATTLRFEPGITCVVGPNGSGKSNVVDALSWVMGEQGAKSLRGGKMEDVIFAGTTGRPPLGRAEVSLTIDNSDGALPIEYAEVTITRIMFRNGGSEYQINGDTCRLLDIQELLSDSGIGREMHVIVGQGQLDSVLHADPMGRRAFIEEAAGVLKHRKRKEKALRKLDAMKANLARVQDLTDELRRQLKPLGRQAAVARRAAVIQADLRDARLRLLADDLVRMRGALRAEIEDEAALKERKDAAEAELKKALQREALLEAEVRQLTPRLQRAQQTWYELSQLAERVRGTVSLADARVKSATSAPAEERRGRDPEDMEREAARIREQEAELEAALEAAERALDDTVAHRADLERELAAEERRLKDAARAIADRREGLARLNGQVNAARSRAAAAQAEIDRLAATRDEARERAVAAQEEYEQLKVEVDDLDAGDAELGDRHDAARAALADAESALTAAREALTSAERKRAAVSARHDALALGLRRKDGTGALLGARDRLTGVLGPAAELLSVTPGFEVPVAAAFGAAADAIAVTTPASAAEAIRLLRKQDAGRAALLLAGEDSAWAGGGGASSAGGSVGGGPVAGGDGGVSAAAAGGMSASAGGSPGGGAAGGGDGTGDVHRGGSHPASAASATGAGDVGEGLGGSGRAYPGRAARSGDGPPLVADFVRGPSELMPAVRLLLRGIVVVGTLEDAEDLVYARPELTAVTAEGDLLGAHFAQGGSAGAPSLLEVQASVDEAAGELAELGVRCEELAEAQRAAVARRADAAALVEELGERRRAADREKSSVAQQLGRLSGQARGAAGEAERSAAAAAKAQDALEKAVMDAEELAERLAVAEEMPADEEPDTAVRDRLAADGANARQTEMEARLQARTHEERVKGLAGRADSLDRAARAEREARARAERQRSRLRHEAAVAEAVASGARQLLAHVEVSVGRAEQERASAESAKGERERELVAERARGRDLKAELDKLTDSVHRGEVLGAEKRLRIEQLEAKALEELGVEPAGLVAEYGPQQPVPPSLPAEGEELPDDPEHPRNQPRPFVRAEQEKRLKSAERAYQQLGKVNPLALEEFAALEERHKFLSEQLEDLKKTRSDLLQVVKEVDERVEQVFTEAYRDTAREFEGVFSRLFPGGDGRLILTDPDNMLTTGVDVEARPPGKKVKRLSLLSGGERSLTAVALLVSIFKARPSPFYVMDEVEAALDDTNLQRLIRIMQELQEASQLIVITHQKRTMEVADALYGVSMQGDGVSKVISQRLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-05-25" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JSB5</accession>
    <name>A0A2M9JSB5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Polyamine ABC transporter substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CG723_21450</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000007">
        <property type="protein sequence ID" value="PJN09766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN09766">
        <property type="protein sequence ID" value="PJN09766"/>
        <property type="gene ID" value="CG723_21450"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042597">
        <property type="term" value="C:periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019808">
        <property type="term" value="F:polyamine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015846">
        <property type="term" value="P:polyamine transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006059">
        <property type="entry name" value="SBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001188">
        <property type="entry name" value="Sperm_putr-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13416">
        <property type="entry name" value="SBP_bac_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00909">
        <property type="entry name" value="SPERMDNBNDNG"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PJN09766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="385" mass="42847" checksum="C3A4171D9FB3CEBA" modified="2018-04-25" version="1">MRALGGGAAAAAVGALASGCGVPAAYVAPGDRAATDRSGSDKRLVFANWPLYIDVDDDDPSKRPTLDAFQKQTGIDVKYTEEINDNDEFFGKISPSLMNHQKTGRDLIVISDWMCAKFVTLGWVQEMDRARQPHVTKYLDPLLRSPHFDPGRKYTVPWQSGITGIAYNKRRVGREIKHVSDLWAADLKGKVTLLSGLDESFALLMQGNGVDITRWTPDDFHRVCDQVEKLVKSHHIRRFTGNDYIKDLSSGDVLACQAYSGDVIQLQADDPDIEFVVPEEGGELWAESLMIPNLADHKRNAERLIDFYYRPEVAAELATWVNYVSPVPAAREILADSKDKDTAALAEDPLIFPDDTMRARLAIARDITSKERPEFAKRWNAIAGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JSR3</accession>
    <name>A0A2M9JSR3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">AsnC family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CG723_19540</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000006">
        <property type="protein sequence ID" value="PJN09931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN09931">
        <property type="protein sequence ID" value="PJN09931"/>
        <property type="gene ID" value="CG723_19540"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000485">
        <property type="entry name" value="AsnC-type_HTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019888">
        <property type="entry name" value="Tscrpt_reg_AsnC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019887">
        <property type="entry name" value="Tscrpt_reg_AsnC/Lrp_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019885">
        <property type="entry name" value="Tscrpt_reg_HTH_AsnC-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01037">
        <property type="entry name" value="AsnC_trans_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13404">
        <property type="entry name" value="HTH_AsnC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00033">
        <property type="entry name" value="HTHASNC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00344">
        <property type="entry name" value="HTH_ASNC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00519">
        <property type="entry name" value="HTH_ASNC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50956">
        <property type="entry name" value="HTH_ASNC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH asnC-type" evidence="4">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PJN09931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="144" mass="15524" checksum="B50B293C385EB595" modified="2018-04-25" version="1">MDEIDRKLVALLQRDATTAYAALGKEVGLSAGAAHERVRKLRERGVIRRTTVDVDPAALGQGVLAFVMVESSSWMGESAGEFAAIPEIQEAHVIAGSASVLVKVRTETTQQLQDVLRRLYAIEGVSGTQATVALETFFERPVVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JSS6</accession>
    <name>A0A2M9JSS6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycosyl transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_19370</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000006">
        <property type="protein sequence ID" value="PJN09903.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN09903">
        <property type="protein sequence ID" value="PJN09903"/>
        <property type="gene ID" value="CG723_19370"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_2-like" evidence="1">
        <location>
            <begin position="5"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN09903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="326" mass="36420" checksum="93F77AFC8E4D98D3" modified="2018-04-25" version="1">MVKLSVIVPFYNVQQYAPDTLRSLRANARDDFEFILVDDCSKDETPDILARAERELPGAVLVRHEKNGGLATARNTGLDASRGEYLTFLDGDDWLAPGYYERLLASIEGLGCDFVRTDHVQCTARARTVHRVPTGRRGVVMDPREAILPADRSTSVDYAYAWAGMYHRRLADAGLLHFTDGLRTAEDRPWIWRLHREAKSFAAVGLLGVFYRRGVASSLTQIGDVRQLDFIKAFDQVVAETAQDQDAEKLLPKAVRTYCAIISHHLGSIERFEPAVARKLKTLSSAALKRMPQDVLDDALDSMDVQRATRLRRLRRRPAAAGVAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JSU6</accession>
    <name>A0A2M9JSU6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CG723_19495</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000006">
        <property type="protein sequence ID" value="PJN09923.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN09923">
        <property type="protein sequence ID" value="PJN09923"/>
        <property type="gene ID" value="CG723_19495"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PJN09923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="185" mass="19621" checksum="4D4438183BA085E3" modified="2018-04-25" version="1">MSLVELIAQADERGLAASGLACLDRCVPLLGAEDDEALRPLWASLAEGGPEWGECLAKARAAFPAGPDDDADEASGLARRMLAAVPDTPSAPALREWADACSVGALQIHRMLDTMEDGAGSVRSRREGRTDGMSPLVAAELRRQVRILELLAGRGASGLRQALDVSTEGRRILRAVVSRRARGRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JSZ0</accession>
    <name>A0A2M9JSZ0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CG723_19900</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CB01635</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000006">
        <property type="protein sequence ID" value="PJN09990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN09990">
        <property type="protein sequence ID" value="PJN09990"/>
        <property type="gene ID" value="CG723_19900"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032808">
        <property type="entry name" value="DoxX"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07681">
        <property type="entry name" value="DoxX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="27"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="88"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="113"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="144"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PJN09990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="175" mass="18698" checksum="00792BB509B86485" modified="2018-04-25" version="1">MTHGMRTDIHTDYVNGRGSWRDNAQRFALLPLRIFLGVTFIYAGLDKLTDSAFFHATGSGSIGEQMRGVRDISAIPAMVDLALKSPTGFGYAIAFGELAVGIGTLIGLLARLAAVGGMLISLSLWLTVSWATEPYYLGNDLAYLMAWLPLVLAGASVFSVDAMLAARRRARGGLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JSZ6</accession>
    <name>A0A2M9JSZ6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_19775</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000006">
        <property type="protein sequence ID" value="PJN09968.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN09968">
        <property type="protein sequence ID" value="PJN09968"/>
        <property type="gene ID" value="CG723_19775"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="155"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="188"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN09968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="271" mass="28403" checksum="E90461E32D68626A" modified="2018-04-25" version="1">MPDRSLRLPLPPAGSTLLREGCPTPPPPQDTPPKSSDSSKPSKSSKSSKSSKDENPFAPPPEGSPDRPWQPRRPEGGQDGQGDGSGGDRNPWGGQWSDRQPGRAQGGRFGDRPGQGGGPGGQGGPEGPQGPGSGMRWDPTDPAQRRARYALLSGMWGFFFALFSWPYVALLLGALALYWGITALRAKPRTPNPDAPAPTGPAAGSRPQTTAAVSGLVTGSLALALVAATFTAQLVYSDYYTCVNDALTSASQKACNDKLPKELRTLLGTRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JTC9</accession>
    <name>A0A2M9JTC9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CG723_19515</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000006">
        <property type="protein sequence ID" value="PJN10134.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN10134">
        <property type="protein sequence ID" value="PJN10134"/>
        <property type="gene ID" value="CG723_19515"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006144">
        <property type="term" value="P:purine nucleobase metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3330.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018020">
        <property type="entry name" value="OHCU_decarboxylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036778">
        <property type="entry name" value="OHCU_decarboxylase_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09349">
        <property type="entry name" value="OHCU_decarbox"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158694">
        <property type="entry name" value="SSF158694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0659">Purine metabolism</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OHCU_decarbox" evidence="3">
        <location>
            <begin position="22"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="domain" description="OHCU_decarbox" evidence="3">
        <location>
            <begin position="95"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="170"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF09349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PJN10134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="199" mass="21652" checksum="DFA76A16FADE15D7" modified="2018-04-25" version="1">MQCSPGHASPLQSSPHGLTRFNTLPATEAERALLTCCGSLHWACRLVAHRPYPDLDALLAAADEAVYDFAPADLDEALSRESLPLTPHRSYSVAHTALGAAHSAYESRFGHAFVICLDGYGPDEALDQLLAGIRSRLGNDPEEERVLSWDELRRLARGRLVRLVRSLDARTEPQEAIDPQEPADSGRPDSASDSPYVAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JTI2</accession>
    <name>A0A2M9JTI2_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Peptidase_S8 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CG723_17510</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CB01635</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the peptidase S8 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000005">
        <property type="protein sequence ID" value="PJN10196.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN10196">
        <property type="protein sequence ID" value="PJN10196"/>
        <property type="gene ID" value="CG723_17510"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07474">
        <property type="entry name" value="Peptidases_S8_subtilisin_Vpr-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000209">
        <property type="entry name" value="Peptidase_S8/S53_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023827">
        <property type="entry name" value="Peptidase_S8_Asp-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022398">
        <property type="entry name" value="Peptidase_S8_His-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023828">
        <property type="entry name" value="Peptidase_S8_Ser-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015500">
        <property type="entry name" value="Peptidase_S8_subtilisin-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034213">
        <property type="entry name" value="S8_Vpr-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00082">
        <property type="entry name" value="Peptidase_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00723">
        <property type="entry name" value="SUBTILISIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="SSF52743"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00136">
        <property type="entry name" value="SUBTILASE_ASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00137">
        <property type="entry name" value="SUBTILASE_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00138">
        <property type="entry name" value="SUBTILASE_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 5" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0720">Serine protease</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014663955" description="Peptidase_S8 domain-containing protein" evidence="7">
        <location>
            <begin position="30"/>
            <end position="1415"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_S8" evidence="8">
        <location>
            <begin position="157"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="417"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="795"/>
            <end position="836"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="818"/>
            <end position="836"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PJN10196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="1415" mass="145912" checksum="CD522465400FFCA9" modified="2018-04-25" version="1">MTPRRTFTPGLTAAVISGLLSAVPQSAGADPHQDPERRVIVTLSGDAAATGKGTLRSADAKEIGADRASLAARQKKFLGDAKDAGLSTGAPRRLNLLLDAVAVTVKASEVAELKQLPGVVSVVPDSKVHILTDDSVPLINAPQVWQRKDPAGNGADGKGVTVAILDSGVDYSHPDLGGAFGKGHKVVGGYDFVNGDADPMDDNGHGTHVAGIIAGKAAEKGGVTGVAPGADLLAYKVMDAAGEGYTSDIVAGIEAAIDPADPHRADVINMSIGGYGDGHDPLGLAATAATKAGVVVVASAGNEGPDSGTVGSPAAADGVIAVGASISGLRIPGAAYKGGKKIQTYRGMISANPPAKPVTTELVDLGQGTPEDWERAGDVKGKVVRVEMTVAAVRDDLYASEIETAREAERRGALAVIGGQNSGGGPVLAGGPDTAGQPGGSGQARGSGQPPPGADGTVPLGPATSVKESGDSLRMDSMVMLGVDATQFAELGRRLADGKVEVTISGTDVTDKIASFSSRGPDLNRNLKPDLVAPGYDIRSTVPKSLYAPGYYRMSGTSMAGPHVAGAAALLRQLRPGETPAQVTSELVGSAKELKDYGTTTTGSGRLDVAAAADRADAAVTTTPATLSYGLADLSRHTVGGSKKLRVNNSGTRTRTVRLKVSGEARVSPRILRIPAGGSATATVALSADRPEGEAEISGTVTVTPEHGAALRIPYLLVVRQLFVQAGPDPSDGKSTAVVFTPAPLAKPPVLTVTPPHGRPYTVTTGLRSGNVYQAEITGRGIGAHLVSVTGRTTDGKTLTSNRDGFEVTPEDSRDSRWQPVGPNSESGNITTAKSDSGAALLTQYNKLGPWSTDDKGETWKQHPRLPIGDVSGQAFTVVDPKNAKRWWYASNSASGIPRTSSILRTEDGGRTWKTLDTPDVPLTKFLSDEAAKILVAVTPTDLLISKDGGDTWAKEPIGIPVDEVYDVAIGGDSLYFTAGNSLWKRDGLSTGNLGPATKVHESTDGKVSVTVAADSQVVAIYEIGSGVVGSFDGGKTWSTLDDHGVGGTGMTLTGGDVYVSYGGDIRVGRDHGRQWSTIPSVNDSSVASDFDRWADGSLTVSASSAGVYRGTAEGKDYHRLGVQGGTVNSLAVSGNQLLAAGDQGTHRAQLPVSGSEWGTTGGEGTIGLSTRLLQTSAKDSRIVWRVRNDAFGGFHLERSGDSGATWEEKGASNGTVFALAVHPADPERVYVSYGNLQGMGLFSTEDGGATWKNVLNEQTYFTAVAGDPKNPDRLWLGAPDGLYRSDNGGDDITRVADGRVDTIEFTGSRMLTGGDAIKVSTDGGETFRTGDTGKLPARVSDLLQVGGTLYAATTSYWETALPRGGRGVLRSTDGGRTWQNISTGLQNLDATTLAANGGWLYVGTVQGGVHRLKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JTM2</accession>
    <name>A0A2M9JTM2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Ferric reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CG723_17745</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CB01635</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000005">
        <property type="protein sequence ID" value="PJN10236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN10236">
        <property type="protein sequence ID" value="PJN10236"/>
        <property type="gene ID" value="CG723_17745"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013130">
        <property type="entry name" value="Fe3_Rdtase_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001433">
        <property type="entry name" value="OxRdtase_FAD/NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01794">
        <property type="entry name" value="Ferric_reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00175">
        <property type="entry name" value="NAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="SSF52343"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="SSF63380"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="56"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="95"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="135"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="166"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="201"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="233"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding FR-type" evidence="6">
        <location>
            <begin position="258"/>
            <end position="358"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PJN10236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="484" mass="51429" checksum="79A6C97078DBB521" modified="2018-04-25" version="1">MTTEAASESELSRYPALNAYLRHVEGPGAEYPPIPPRPTRRPRIGRPAAPLRISPGALRAGTVVGGIGVGALWAVQAEPSARLDVLFATGAHLTGLLAGYGILVMLFLMARIPAVEHGVGADRLARRHAAGGRHVLVLCAAHLVLAVCGYATHAGTDLVSTVVALLGYRAVVAAFAGTALLVAVGVSSARAVRRRVTHETWRALHLLTYLGAALGFVHQLAGPDVASGVVTRWLWALLHATVAVLLVWYRLVVPVHQALRHSLRVVAVHGEGPGVFSVVMQGIGLDGLRAEPGQFFRWRFLRGGLWHTSLPFSLSAPVRGDELRITVKALGRHTRRVRRLAPGTRVLATGPFGALTAHRRTRRKVLLLAGGVGITPLRALFETMPGAPGDLTLLYRAGTAEQLVLSGELEAIARSRQAALHYLLGPSDASFDPLAPQALRNLVPELAEHDVYVCGPPGMTAAATAALVRAGVPENHIHAECFTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JUC6</accession>
    <name>A0A2M9JUC6_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">M20_dimer domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CG723_18900</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000005">
        <property type="protein sequence ID" value="PJN10428.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN10428">
        <property type="protein sequence ID" value="PJN10428"/>
        <property type="gene ID" value="CG723_18900"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001261">
        <property type="entry name" value="ArgE/DapE_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036264">
        <property type="entry name" value="Bact_exopeptidase_dim_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017150">
        <property type="entry name" value="Pept_M20_glutamate_carboxypep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002933">
        <property type="entry name" value="Peptidase_M20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011650">
        <property type="entry name" value="Peptidase_M20_dimer"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07687">
        <property type="entry name" value="M20_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01546">
        <property type="entry name" value="Peptidase_M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037238">
        <property type="entry name" value="Carboxypeptidase_G2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55031">
        <property type="entry name" value="SSF55031"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00758">
        <property type="entry name" value="ARGE_DAPE_CPG2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="M20_dimer" evidence="3">
        <location>
            <begin position="200"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="104"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="2">
        <location>
            <position position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR037238-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PJN10428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="404" mass="42092" checksum="0263A1092C050DA0" modified="2018-04-25" version="1">MSAPPRQQPLDEALLALSHAHQARYFEDLAELVAIDSGSYSPDGVNRVADLVRARLERLGFSVERVPLPPAHGRRTGDVLIGRRQGRLAVADGGRRLLLAAHMDTVFDDGAAAERPFSLSGSLAHGPGVSDDKGGLVAGLAALEILARAGVEDFAELVFLATPDEEIGSPASRPVTRRAAEGAHYALALECARENGDLVIARKGVADFRLTVTGRAAHAGIEPERGANAALAAAHLVIAIQALNGRWEGVTLNVGVVRAGSRFNIVCPDAELLVEIRSATDSGLREATAAIQEAAARPVVPGTRATVEELESCPPMEDTDASRRMLHRARDIGVRLGLHFGATATGGVGDANTIAGTGVPTLDGLGPVGGADHTPEEWLDVSSVPARVALLASLIAELGDSRSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JUH9</accession>
    <name>A0A2M9JUH9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_17705</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000005">
        <property type="protein sequence ID" value="PJN10482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN10482">
        <property type="protein sequence ID" value="PJN10482"/>
        <property type="gene ID" value="CG723_17705"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="86"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="116"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="22"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN10482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="140" mass="15565" checksum="6D878417AF4F64D4" modified="2018-04-25" version="1">MPRRERRQRGKEPADMSTEEPQAVPQRPQYTPGSAQPRLNRPVQERYPQIRPTSGYGDPRIQHTGPGPGAGTDQEPERSSKLTARLVLAMTVVIGQLWGLSVVVNEWMMGATGTAWWGAGFLCLSFLVVLGLWLLDPTDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JUL8</accession>
    <name>A0A2M9JUL8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_14950</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000004">
        <property type="protein sequence ID" value="PJN10522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN10522">
        <property type="protein sequence ID" value="PJN10522"/>
        <property type="gene ID" value="CG723_14950"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014631258" evidence="2">
        <location>
            <begin position="30"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="54"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="69"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="110"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="139"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN10522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="217" mass="20965" checksum="86D3AC5435E3DACE" modified="2018-04-25" version="1">MTKKTRIRVARIAAGAVIAAGASLTAAGAASALDIGVNLPGAGVNVHAGEDGVAAGVSLGGDEDPTDPPTGLPTDPTDPTDPPTEDPTDPPTSEPTDPTEEPTEPTEDPTAPTEDPTSPGGNGGNNGGGGHHGGGNGNTDPDGGNNPVEQGQGKDSLQDTGSVPAAQPAQNGKSGGELAETGAAETTFLLIGAATMIAGGIGFRMLPRLVGGGRTVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JUW7</accession>
    <name>A0A2M9JUW7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ectoine/hydroxyectoine ABC transporter substrate-binding protein EhuB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">ehuB</name>
        <name evidence="3" type="ORF">CG723_15820</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000004">
        <property type="protein sequence ID" value="PJN10673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN10673">
        <property type="protein sequence ID" value="PJN10673"/>
        <property type="gene ID" value="CG723_15820"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033294">
        <property type="term" value="F:ectoine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051470">
        <property type="term" value="P:ectoine transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01002">
        <property type="entry name" value="PBP2_Ehub_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014337">
        <property type="entry name" value="Ectoine_EhuB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001638">
        <property type="entry name" value="Solute-binding_3/MltF_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00497">
        <property type="entry name" value="SBP_bac_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00062">
        <property type="entry name" value="PBPb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02995">
        <property type="entry name" value="ectoine_ehuB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="domain" description="PBPb" evidence="2">
        <location>
            <begin position="62"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN10673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="305" mass="32955" checksum="FC6110C5F55E4F55" modified="2018-04-25" version="1">MAPPIWNVTEGTQSLEGNRKGIRRRSLLIGATALGATGALGAAGCSRVPNGDTLARLQGQGTVRLGIAGEVPYGYIDDNGEFTGEAVELAKVIFKRLGVGHVQPVATDFSSLIPGLQTQQFDVVSAGMYINKERCRQVIFSDPEYQMLDSFIVRKGNPKDLHDYADCVKAKAKFGTGTGYAEIAYAVEAGYKESDIVILQDQVAGLNAVEAGRIDVFAGTALTTREVTKKSRKAEHTEPFAPLVGGKKHVDGGGFTFRSNDTAMRDAFNKEIHKMKASGELFRILRPFGFTQAEMTKLTAEELCK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-05-25" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JV07</accession>
    <name>A0A2M9JV07_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Lysine N-acyltransferase MbtK</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Mycobactin synthase protein K</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CG723_16020</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CB01635</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Acyltransferase required for the direct transfer of medium- to long-chain fatty acyl moieties from a carrier protein (MbtL) on to the epsilon-amino group of lysine residue in the mycobactin core.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Siderophore biosynthesis; mycobactin biosynthesis.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000004">
        <property type="protein sequence ID" value="PJN10704.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN10704">
        <property type="protein sequence ID" value="PJN10704"/>
        <property type="gene ID" value="CG723_16020"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00011"/>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019290">
        <property type="term" value="P:siderophore biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019432">
        <property type="entry name" value="Acyltransferase_MbtK/IucB-like"/>
    </dbReference>
    <dbReference type="SMART" id="SM01006">
        <property type="entry name" value="AlcB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="AlcB" evidence="5">
        <location>
            <begin position="15"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003818"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00031122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM01006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PJN10704.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="186" mass="20476" checksum="DBDBF7E06D16750B" modified="2018-04-25" version="1">MSTPTGSPTGTFSIRPLDPVAEAELLHRWVTDPKAAFWLMQDAKLQDVEREYMAIAAAEHHDAFIGLHDGEPAFLMERYDPAHVELVGLYEPEPGDVGMHFLTAPSDVRIPGFTRAVITTVMEFLFADPAARRVVVEPDVRNKAVHALNEAVGFVPDRVIQKPEKQALLSFCAREQFLAATGVAAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JV80</accession>
    <name>A0A2M9JV80_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_16565</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000004">
        <property type="protein sequence ID" value="PJN10791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN10791">
        <property type="protein sequence ID" value="PJN10791"/>
        <property type="gene ID" value="CG723_16565"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014812518" evidence="2">
        <location>
            <begin position="30"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="47"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN10791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="79" mass="8177" checksum="79E28E4F3DC2379C" modified="2018-04-25" version="1">MDKKNALRAGALAAGTTLMMLLMTSPALALARDDGDDPGKGLSVIETLGLYVVAPIVLFLVIAGLVIVGDKSRKPQKQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-09-29" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JVP1</accession>
    <name>A0A2M9JVP1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Methylmalonyl Co-A mutase-associated GTPase MeaB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_08110</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SIMIBI class G3E GTPase family. ArgK/MeaB subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN10971.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN10971">
        <property type="protein sequence ID" value="PJN10971"/>
        <property type="gene ID" value="CG723_08110"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005129">
        <property type="entry name" value="GTPase_ArgK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23408">
        <property type="entry name" value="PTHR23408"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00750">
        <property type="entry name" value="lao"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009625"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN10971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="326" mass="35074" checksum="B2EACDA103070B3D" modified="2018-04-25" version="1">MAIELDTYVKGVLDGKRAVIARAITLVESTRPQHRTLAQELLTELLPHSGRSRRIGISGVPGVGKSTFIDAFGTMLTGLGHRVAVLAVDPSSSRTGGSILGDKTRMERLAVDPAAFVRPSPTSGTLGGVAKATRESIVVMEAAGYDVVLVETVGVGQSETAVANMVDTFLLLTLARTGDQLQGIKKGVLELADVISVNKADGPHERDARAAARELAGALRLMHGKDAFWTPPVLSCSARESTGLDAVWERLEQHRTLLDSAGRLAARRRDQQIDWTWAMVRDELLGRLHADPAVRSLAPNLERQVREGELTATLAAERILDVFRNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JVZ4</accession>
    <name>A0A2M9JVZ4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CG723_15825</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000004">
        <property type="protein sequence ID" value="PJN10927.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN10927">
        <property type="protein sequence ID" value="PJN10927"/>
        <property type="gene ID" value="CG723_15825"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024532">
        <property type="entry name" value="DUF3830"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12903">
        <property type="entry name" value="DUF3830"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="SSF50891"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PJN10927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="169" mass="18521" checksum="960C5226DE31B41F" modified="2018-04-25" version="1">MEGMADRYIEVSLAKRGVQCTAKLLDDRAPLTCAAVWDALPLGSDVYHAKYARNEIYALFPAFADREPPLENPTITPIPGDLCYFSFSGTELGTQAYGYESGAELKPGAVVVDLALFYERNNLLINGDVGWVPGIVWGQVVEGLDRMAEACQDLWRGGALGETLEFRRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JW26</accession>
    <name>A0A2M9JW26_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CG723_08810</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CB01635</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN11064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN11064">
        <property type="protein sequence ID" value="PJN11064"/>
        <property type="gene ID" value="CG723_08810"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035673">
        <property type="term" value="F:oligopeptide transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004813">
        <property type="entry name" value="OPT"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03169">
        <property type="entry name" value="OPT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="30"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="56"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="95"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="120"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="180"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="230"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="291"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="315"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="343"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="412"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="484"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PJN11064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="548" mass="56485" checksum="C53EC25F271BFCA8" modified="2018-04-25" version="1">MSRTDAAPQAETSHTASQGRHHPRALAPGNLILTVVLSVFGAVVGVQLLATLGVTPSTSLIGALAAMTLARVPLVRLRGFRSVHAQNLAQTSISSATFGAANSLFLPIGIPFLFGMDNMIIPMLIGVAAAMLVDAWLLYRMYDTPAFPAKNPWPPGLAAAEAIKAGDEGGRRAKVLGLGLLTGLAGAVFTLPMSAFGVALIGGFAAMAAFGVGLLFTQYAEPLFGLDLNAMYLPHGMMIGAGVVALVQVGRTILKARRTAADEARAAAPAGAPEGTRDGAQRLGRSMRLGFGAYLVISILLAFGTGAAAHMSPGMLIGFLVYATVAAFVHELLVGIASMHSGWFPAFAIALITLLLGILIGFPPEALVVLSGFTAATGPAFADMGYDLKAGHLLRGENADPAFELEGRRQQLIAAMIGFGVAIVVVLVSYRMFFDNGQTAPIDAAYVAAIKAGPSVETAQHLALWAIPGAIVQIVGGSRRQLGILLATGLLITTPMAGWMVAAGIAVRVLAPRVLGPKAKEDLEVFAGGAIAGDALYSFGNGVFKAAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JW86</accession>
    <name>A0A2M9JW86_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HTH tetR-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_09380</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN11156.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN11156">
        <property type="protein sequence ID" value="PJN11156"/>
        <property type="gene ID" value="CG723_09380"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="3"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="26"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN11156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="185" mass="20361" checksum="03339C91D252AFF1" modified="2018-04-25" version="1">MNTEKRAELLGQVMEYVQRHGLANLSLSPLAEEIGTTKRMLLYYFGSRGNLLARALAASRPDAHAMFDTVEDTADLRRSARALWKAITVGEQAGPIRMLLQLLSLAATDPDQYGDLARETVEVMIGPIADAVVRLGHPREVARERATLLVSGLRGLCQDRLVTDDAARTDAAAFHLIETVVEPRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JWB1</accession>
    <name>A0A2M9JWB1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CG723_09135</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN11118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN11118">
        <property type="protein sequence ID" value="PJN11118"/>
        <property type="gene ID" value="CG723_09135"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PJN11118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="146" mass="16406" checksum="77F7E5FF0218CE77" modified="2018-04-25" version="1">MIALCALALSAATAYVQHRARKRETLGADVTAYFHRTSDFARIKLFDGTVRQAGYHLVIWNHGPAPAERVHLAVVDVEGAVVELADCPPDEFPLQRLDKGARYPVPWIPVSDTHRGARRFTVHLRWQDGNGTQERLLPMRRGQTNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JWL5</accession>
    <name>A0A2M9JWL5_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">TIR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_09720</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN11212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN11212">
        <property type="protein sequence ID" value="PJN11212"/>
        <property type="gene ID" value="CG723_09720"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003953">
        <property type="term" value="F:NAD+ nucleosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019677">
        <property type="term" value="P:NAD catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000157">
        <property type="entry name" value="TIR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035897">
        <property type="entry name" value="Toll_tir_struct_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13676">
        <property type="entry name" value="TIR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52200">
        <property type="entry name" value="SSF52200"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50104">
        <property type="entry name" value="TIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TIR" evidence="2">
        <location>
            <begin position="360"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="550"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="573"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="605"/>
            <end position="627"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN11212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="737" mass="81799" checksum="E106CFFE4F82949A" modified="2018-04-25" version="1">MTGSRRSATDPPPISNLPVQATPFVGRDEEIAAVHDLFEDHRAVLLHDPADRQHGYGKSEAAITYCHRYRMRYRVAWWFNCSHESDPHRLRQLIERGTDELHTRYREVLRVTDIPERPDDKWLLLYDNVADPDRIQDLFPAGDARILVTSRPPGGGWDEAARLPVDDLDPAEVASLFRQLAEIRQPVAEDLARAFAGHPQQIIAVAEQIRRGTPPATCVALADAVRLAPAPARPAPPQPSGHVRMSAQDRETLIDTLLSSPVCRDLPSYRAWIKAIDRRAAVSSGLPSETETIRTRVVGLVSIALSRDAPDVLLALAKAFEDRAGRHEAQLVRALIGPAAANWNENKEPIRAVLPPRPADAPFFFTSYANREDDQDHVAEFHEQLEQELRIKRGRNVTSTGFLDRRSLRLGLTWREPMVEAIRSTRLMVALITADYFESEWCRREWAVMTERARRAGRSPGDEPVAILPLFWVKPRGPLPKDLAAIQYSSPALFGGSKAPDNLIDLLREDKKKAAAFIRRLADTMIDAADRDLPALDADAVRDIPLAFGEWDTGDTSLSGSEAGSGPGTGDAQPHPEPQPTPESEPEPAPPEHTPALSLVPDPRVSPDRPEPPVRPTEPPPVTAPNPPAASDKTRLIEALTTGPLREPTRYTPWVEAVLRDVDRAHRPAVTQFVDPLRRRVHLLVNFAYDQTTPDLFRAMARALTLVDPGGATAPDETVTAVHRLVDRIVAAWPHHT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JWT7</accession>
    <name>A0A2M9JWT7_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ribosomal RNA large subunit methyltransferase G</fullName>
            <ecNumber evidence="1">2.1.1.174</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">23S rRNA m2G1835 methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">rRNA (guanine-N(2)-)-methyltransferase RlmG</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rlmG</name>
        <name evidence="3" type="ORF">CG723_10525</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Specifically methylates the guanine in position 1835 (m2G1835) of 23S rRNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>guanosine(1835) in 23S rRNA + S-adenosyl-L-methionine = H(+) + N(2)-methylguanosine(1835) in 23S rRNA + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:42744"/>
            <dbReference type="Rhea" id="RHEA-COMP:10217"/>
            <dbReference type="Rhea" id="RHEA-COMP:10218"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74269"/>
            <dbReference type="ChEBI" id="CHEBI:74481"/>
            <dbReference type="EC" id="2.1.1.174"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the methyltransferase superfamily. RlmG family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.174" evidence="1"/>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN11353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN11353">
        <property type="protein sequence ID" value="PJN11353"/>
        <property type="gene ID" value="CG723_10525"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052916">
        <property type="term" value="F:23S rRNA (guanine(1835)-N(2))-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01859">
        <property type="entry name" value="23SrRNA_methyltr_G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002052">
        <property type="entry name" value="DNA_methylase_N6_adenine_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017237">
        <property type="entry name" value="rRNA_m2G-MeTrfase_RsmD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007848">
        <property type="entry name" value="Small_mtfrase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47816:SF5">
        <property type="entry name" value="PTHR47816:SF5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05175">
        <property type="entry name" value="MTS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037565">
        <property type="entry name" value="RRNA_m2G_Mtase_RsmD_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00092">
        <property type="entry name" value="N6_MTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="1" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="1 3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="MTS" evidence="2">
        <location>
            <begin position="210"/>
            <end position="384"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN11353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="394" mass="43139" checksum="783C055FBB5BB7E5" modified="2018-04-25" version="1">MSNRFETSWGEFDLARFPEDSHDPLRAWDAADEYLLRHLADSATDLSGSVVVIGDRWGALATSLAGHCDRPTAISDSYLGQRATRANLDRAGFDENAVRLLTTQDAPPERVDVLLVRVPKSLALLEDQLHRIASAVHEDTVVIGTGMVKEIHTSTLKLFERIIGPTRTSLAEKKARLIFTTPFPALARPRNPWPHRYALPDGVGPVSGRTVTNHAGVFCAERLDIGTRFLLQHLPRSEGAERVVDLGCGNGVVGTAMALENPRAEIVFTDESFQAVASAEATYRANVDPSEHPEARAEFLVGDGLAELPAGSADLVLNNPPFHSHQATTAATAMRMFSDARDALRPGGELWVIGNRHLGYHVKLRRLFGNSELIASDPKFVVLRAVKKEREPRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-09-29" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JX06</accession>
    <name>A0A2M9JX06_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Growth inhibitor PemK</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_10455</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN11342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN11342">
        <property type="protein sequence ID" value="PJN11342"/>
        <property type="gene ID" value="CG723_10455"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003477">
        <property type="entry name" value="PemK-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011067">
        <property type="entry name" value="Plasmid_toxin/cell-grow_inhib"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02452">
        <property type="entry name" value="PemK_toxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN11342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="152" mass="17233" checksum="43D139341DF72CFE" modified="2018-04-25" version="1">MTAFIDDPHAHEHPGRAGATATVEAAPREVGRVRTEYAPAHDGDPDPGEIVWTWVPFEENDGRGKDRPVLVVAREAAGTLLAVQLSSKRHDHDREWVPIGSGPWDTAGRDSWVAIDRVLRVHERGMRREACALDRMRFNLVVLRLRERYGWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JX32</accession>
    <name>A0A2M9JX32_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="10">ABC transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CG723_11070</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN11443.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN11443">
        <property type="protein sequence ID" value="PJN11443"/>
        <property type="gene ID" value="CG723_11070"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221">
        <property type="entry name" value="PTHR24221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="SSF90123"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="186"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="301"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="327"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="9">
        <location>
            <begin position="115"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="8">
        <location>
            <begin position="392"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="426"/>
            <end position="433"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PJN11443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="660" mass="71225" checksum="37AA8FA6EAFA4CE9" modified="2018-04-25" version="1">MRLLRRPEPGAPVVSASERELFGGPLRYDAGWSKHEYARLDLTLWSALKSLPHLVLQTVRLAWHTDRRSLITVGVTEVGQGIAAALKLLAVNAALHAVVATGTDVRGLRDALPAVVMTAVVLAANALLASRSTAAAGSLEPKVERAASEQYLAACQRVEMSAIEDGTFRELIDRAQYGANEARHMIGSSVAAINSVLALVAAGGVLSVLNPALLPMLFLIVAPRGWGVMRVAQQRYFSTMTWIEHLRASRVLSNLLTSVTAALEVRVHHVGAFLLRHYRIMAHTAESEQARLAKDKARTELAASALSGLGYALTFTVMIGLCLTGRMSVAVFGTAIMAINAGSAGIGALVNTMSQLHEQSLYVHDLTDFLKKAEDLAIPEGGLALPARPRSIRLDNVSFRYPGRDEPAVDSVSFSVELGSVIALVGPNGSGKSTLVRLLSGLHLPGEGHIHWDDVDISEADRRQLFGHVSLLTQTFERWPFTAAANIRIGQPDRDVTDEDLRTSAAYAGADRDIAGLPHGMNTLLGKNFRGASDLSGGQWQKIGLARAHFRDACLVIVDEPTSALDPDAEQRAFDQILGLAGPDRIIVLVTHRMAAVRRVDRIFVLDEGRLIEEGSHAELFAAEPASRYAHMYRLQADQYEHARPAQLPGPTRPPASEPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JX56</accession>
    <name>A0A2M9JX56_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DeoR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CG723_11200</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN11465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN11465">
        <property type="protein sequence ID" value="PJN11465"/>
        <property type="gene ID" value="CG723_11200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014036">
        <property type="entry name" value="DeoR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001034">
        <property type="entry name" value="DeoR_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00455">
        <property type="entry name" value="DeoRC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08220">
        <property type="entry name" value="HTH_DeoR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00037">
        <property type="entry name" value="HTHLACR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00420">
        <property type="entry name" value="HTH_DEOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="SSF100950"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51000">
        <property type="entry name" value="HTH_DEOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH deoR-type" evidence="3">
        <location>
            <begin position="6"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PJN11465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="260" mass="27810" checksum="F3D70AAE26094BA2" modified="2018-04-25" version="1">MPPTTSQARRDRIVHLATTTGLASVEELSQLFDVTPSTIRRDLARLTTEGRLARTYGGAMALSAHPEASLRQRTGEAYEEKRAIAQWAARQVEPGETLLLDAGTTVGALAHELRGAKDLTVATTGLTALHALADAEGVDVECLGGTLRPLSQGFVGPLTEAALEHMSFDRVFLGADGVTVDRGICEADLRQTRLKELMARRADRVYVLAHGAKLGRAPFHAWAKLRKEWTLVTDASAPDAQIRAFGASGVRVEIAPPAGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JXT4</accession>
    <name>A0A2M9JXT4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">SAM-dependent methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_12545</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN11689.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN11689">
        <property type="protein sequence ID" value="PJN11689"/>
        <property type="gene ID" value="CG723_12545"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransf_11" evidence="1">
        <location>
            <begin position="39"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN11689.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="207" mass="22445" checksum="F68B394DEA06AFC4" modified="2018-04-25" version="1">MGFYAEQVLPRIIDVACGVKMTAPLRRRVCEGLRGQVVEIGFGTGHNVPYYPSTVEGVVAIEPSDVGWRLAAERVGAASVPVRRAGPDGQSLPFEDNSFDTALSTWTLCTIPDAGAALREVRRVLRPGGTLHFLEHGLAPEEDENVRRWQRRMEPVNKRLFGGCHLTRPITDLLTEAGFTITALDAFYEQGPPKPIGAASLGVALAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JY05</accession>
    <name>A0A2M9JY05_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_13005</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN11766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN11766">
        <property type="protein sequence ID" value="PJN11766"/>
        <property type="gene ID" value="CG723_13005"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014799577" evidence="2">
        <location>
            <begin position="25"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="119"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN11766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="163" mass="16788" checksum="7FE1315F2EB34793" modified="2018-04-25" version="1">MLRTRFLSVAAASLFAWLGPAAPAVSEPPDATVTVTSPAADSVHPVNSSLFVRWRNDTGQEVDVWLTQGDSEGGAQRLFKLASKASSKPETELVAAVPPVPDGADYTVEVTARDTGVRGYSAPFEVGPVPAEAPAVGTGSGSGSEKAAAPLSWVQAQDGQSPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JY58</accession>
    <name>A0A2M9JY58_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_13305</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN11816.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN11816">
        <property type="protein sequence ID" value="PJN11816"/>
        <property type="gene ID" value="CG723_13305"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="28"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="113"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN11816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="141" mass="14863" checksum="5037EBC78627B3B0" modified="2018-04-25" version="1">MAKYTVAQHITRFFWLPRGTERHQPTSYARLTGIWLASIAVGTAVTAAGGAEEYGGADIMMVIVVLNVIDDIITGVRHRWPAALAAVALLYGGSRLTGAVLSDSLDTDWATTIAAAVGVTLSLAATATLTRLPQRPATTAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JY77</accession>
    <name>A0A2M9JY77_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">3-oxoacyl-ACP reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CG723_13325</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN11819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN11819">
        <property type="protein sequence ID" value="PJN11819"/>
        <property type="gene ID" value="CG723_13325"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PJN11819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="262" mass="26678" checksum="9E7CF11B4E036ED8" modified="2018-04-25" version="1">MELKLQGRAAVVTGASKGIGLAITKALAAEGVRVTAGARHVGGELADLARTGSVQAVEVDLATTEGPAVLVSAAGSAFGPPDILVNNVGAVRTRTGGFSSVTDQDWTTTLDINFLASVRATREVLPLMLQRTAGSIITVASINARLPDPLVIDYCAAKAALLSFSKSLSKELGPSGIRVNTVSPGPVATDLWLGKDGVAATVGQAGGLEADAVIEHVAREAATGRFTHPEEVAELVLLLASDRTANVTGSDFVIDGGMITTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JY83</accession>
    <name>A0A2M9JY83_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF1918 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_13410</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN11833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN11833">
        <property type="protein sequence ID" value="PJN11833"/>
        <property type="gene ID" value="CG723_13410"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015035">
        <property type="entry name" value="DUF1918"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08940">
        <property type="entry name" value="DUF1918"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF1918" evidence="1">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN11833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="72" mass="7902" checksum="39ECE65ABE89ACA1" modified="2018-04-25" version="1">MEAKKGDYLTLHGLRGDRTVRVEEIISGTNRDLYQVAFSDGHTAVVAPGPDVEKAHCKRHTHVVDVSGSPYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JYA3</accession>
    <name>A0A2M9JYA3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Asp/Glu/hydantoin racemase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_13545</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN11855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN11855">
        <property type="protein sequence ID" value="PJN11855"/>
        <property type="gene ID" value="CG723_13545"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036361">
        <property type="term" value="F:racemase activity, acting on amino acids and derivatives"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006807">
        <property type="term" value="P:nitrogen compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015942">
        <property type="entry name" value="Asp/Glu/hydantoin_racemase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01177">
        <property type="entry name" value="Asp_Glu_race"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014825397" evidence="1">
        <location>
            <begin position="23"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN11855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="241" mass="25151" checksum="05B507A5C5DD2EF5" modified="2018-04-25" version="1">MRILVVNVNTTASMTESIGAQAAAVASPGTEIVPLTPSFGAESVEGNYESYLAAVAVMEAVRSYPHSFDAVIQAGYGEHGREGLQELLDVPVVDITEAAASTAQFLGHRYSVVTTLDRTVPLIEDRLKLAGLADRCASVRASGMAVLDLESDAEAAVEAIVEQAAQAVERDKAEVICLGCGGMAGLTERVVERTGVPVVDGVAAAVTIAESLVRLGLSTSKVRTYAAPRTKAIKNWPPRAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JYC6</accession>
    <name>A0A2M9JYC6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CG723_13680</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN11875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN11875">
        <property type="protein sequence ID" value="PJN11875"/>
        <property type="gene ID" value="CG723_13680"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046038">
        <property type="entry name" value="DUF5996"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19459">
        <property type="entry name" value="DUF5996"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PJN11875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="317" mass="34738" checksum="4C8B5DF156B4A976" modified="2018-04-25" version="1">MSERRATWPELVYEDLAPMVGYVNRLVQVGGKYTLDEPFEAGWGNIVLDVTSRGLRTPTHRRQGVTFEVHYRLLDGDVVIESDRGSVTVPLSNGSLAAFYTSFCDAAAELGVRPPRTSLICEIPGAPRKFEDDQIERTWDGEAARLMSTAFNLAAGGLETWQAPFQGHRPRVGVMWGGFDLSATRYRAHRATPEADRPAFMQNAARDEYVSVGFTFGDAKSPNAGMYAYIWPQPDGLEGRSWGVDGAAWSADAGLALLPWTTLRDMADPHQAIVAFGDAVYDAAVETAGWPADLIGPRCNGWRMSTTPPAADRGRDH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JYZ5</accession>
    <name>A0A2M9JYZ5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">FUSC family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_08775</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN12102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN12102">
        <property type="protein sequence ID" value="PJN12102"/>
        <property type="gene ID" value="CG723_08775"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="43"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="71"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="116"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="400"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="449"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="478"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="175"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="560"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="176"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN12102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="707" mass="73646" checksum="F6C09C8A9587E556" modified="2018-04-25" version="1">MAAGAGFYLCLYGFGSAEAATYALFAAVSLAGLSHIPGTGRQRATVVARLLPVCLVLIIVGTYLSVQTWSATAGMLVVGFALAFSAVGGPRPAGAAPGLQLMYILPSFPPYDPGSLGVRLAGASVGIVFLVLAETFLLPDPPTVPYRELAARAADSARRCAEELTGPPYAVTARTAQEAQAASSALRSSQVPEAERPAGPSVRARGLAHTGLATRTLLARLTAPPQWNPGPAESEVWLVVLRAVRDTARETADRLRGRAPAAGDAHAELLRARTALAAGPEADAAPAALRRHAAVLELADAALAMSTAAAIAVRGRAGAAQAAPGRFWYARKRAPQLWWWRMAGHAGARSVFFQNAVRISLALAAARLIAGVDTLPHGFWVLLATLTLTRTTVRETRSTVRVALTGTLVGALIVAGLLTLVGTNIAVYAAVLPPLMLITFTLGPVKGIGWAQAMFTLVVALAFAQLAPTTWQLAEFRLLDVLTGSAIGAVFGLLAWPRGAHDELRRSMAVLLRGAAENVVATSAQVAAGGVRAPVKAAPGHHSLQHSLVMAESAYAQFQSEPKGLTTARPGRDPQGSTGPHEPAGQDGSQDWQATLMAAHHTLWGADRLLVPAERIVVPPLELEPSAAVSRLGDRVAGRMLLVSARLDPGGDTPQAPVPLRDPDFDGFAVEPPGAPRVYYAAVSWLDALMTDLERITGEAAAASPGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K031</accession>
    <name>A0A2M9K031_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CG723_05515</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CB01635</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000002">
        <property type="protein sequence ID" value="PJN12493.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN12493">
        <property type="protein sequence ID" value="PJN12493"/>
        <property type="gene ID" value="CG723_05515"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="34"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="101"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="134"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="165"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="222"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="265"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="97"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PJN12493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="303" mass="33258" checksum="1A0CE13B958F90CF" modified="2018-04-25" version="1">MSTTTVDTPATGAQPVTDTVRPRRVRRRGERSRLATFLSHGVLSVASLTALFPIAWLVYLSLGPDKDDYLHPGRILDKATFSNYSFVLEHTNFFKWLQSTLIVSLGTTVVGVLFAATTGYAVSRMRFPGHRKLMWVLLLTQAFPIAVLIVPMYEILGDLGLIDTYGGLILVYCSTAVPYCAWLLKGYFDTIPYEIDEAGRIDGLSPFGTFARLIVPLAKPGLAVAAFYSFITAFGEVAFASTFMLDDEKYTFAVGLRSFVSEHDAQWNYMAATAVLIAIPVSAFFYLVQRNLVTGLTAGGTKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K166</accession>
    <name>A0A2M9K166_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Sugar kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CG723_07080</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000002">
        <property type="protein sequence ID" value="PJN12767.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN12767">
        <property type="protein sequence ID" value="PJN12767"/>
        <property type="gene ID" value="CG723_07080"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016773">
        <property type="term" value="F:phosphotransferase activity, alcohol group as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002173">
        <property type="entry name" value="Carboh/pur_kinase_PfkB_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011611">
        <property type="entry name" value="PfkB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00294">
        <property type="entry name" value="PfkB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="SSF53613"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00584">
        <property type="entry name" value="PFKB_KINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PfkB" evidence="3">
        <location>
            <begin position="5"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PJN12767.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="299" mass="30017" checksum="97DA85C83EB65064" modified="2018-04-25" version="1">MSGTLLVVGDVVTDIVARHDAPLAAGTDTAAEIRTLPGGAGANVACWAAHSGCPDVALLGRVGADSAAWHEEALTRARVRPRLVVDPEAATGTVIALVDTGAGAERTFLTDSGASLRLSPADWSADLLGGVAWLHLSGYLFFSAEGRGLVAAALASARARGVPVSIDPASAGFLRELGPDRFLALAKGVDILLPSRDEAELLSGVGDAEVAAAKLSGWFPLVVVTSGVAGAVVAQDGTVRARVPSLPAVARDSTGAGDAFTGAFLAAWVRGAGPREAATDGCHAGALAVARVGGRPPQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-09-29" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K175</accession>
    <name>A0A2M9K175_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Export associated protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_07135</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000002">
        <property type="protein sequence ID" value="PJN12777.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN12777">
        <property type="protein sequence ID" value="PJN12777"/>
        <property type="gene ID" value="CG723_07135"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06974">
        <property type="entry name" value="TerD_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003325">
        <property type="entry name" value="TerD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02342">
        <property type="entry name" value="TerD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TerD" evidence="2">
        <location>
            <begin position="65"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="213"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="337"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="222"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="244"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="265"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN12777.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="663" mass="69538" checksum="51002F4645269E96" modified="2018-04-25" version="1">MTAELVRGQNHPLTQNRLEIRVSAGAPIVAGATLSDDQGKVHGRDWVAHPGAPALPGLEVPRQAAADHRLAVDLDAVPESAHRVSVLLALPTGPGDPDRFGAVAAPFVAVTGLDGSEVASYTITDLDAESAVVALELYRRQGAWKVRAVGQGYAGGLGALLTDQGLPDAGALAGEIGEAVARGLARTAAPPPPRTAASGASAMVDTGAGASVAGAALPSTTPPRSHQPPEPQSPPAPRPTHEPQPQAHASTQTDGTGPVNYTHPGRQAPAPPAPAPTSSPGAPGQPAVPVAGDATGWSMDERLYNQVWGMFEDLARCVAAYRSAVDFADSRMEQELDKALSDPRSRIGGQGDAAREAARTKHGRLVDQAREALDRDLAQLAAESAVVEPALPPAYAGWDNPVWHAYRSPMEIPMALRLGDLQLPESRGLGLRIPMLVRLPLERGMWIDSGRSGADALTEPDELRRRAMRSAVEHAARLLAVYPAGEFAVHVIDPAGSATGALAPLVRAGVLAGPPAAGMAGVSEVLARLIQRVDLVQMAVRGGAADALPPDLDTAEQLLIVNDFPHGFDDRAVTRLRYLADEGPAVGVHLLMVADREDAAEYGPVLDPLWRALLRLTPVPDDHLADPWVGHAWTYEPPSVPPGSRILEQVLEEVARARREQGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-05-25" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K180</accession>
    <name>A0A2M9K180_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 7">L-ectoine synthase</fullName>
            <ecNumber evidence="4 7">4.2.1.108</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6 7">N-acetyldiaminobutyrate dehydratase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7 8" type="primary">ectC</name>
        <name evidence="8" type="ORF">CG723_07640</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CB01635</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the circularization of gamma-N-acetyl-alpha,gamma-diaminobutyric acid (ADABA) to ectoine (1,4,5,6-tetrahydro-2-methyl-4-pyrimidine carboxylic acid), which is an excellent osmoprotectant.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>(2S)-4-acetamido-2-aminobutanoate = H2O + L-ectoine</text>
            <dbReference type="Rhea" id="RHEA:17281"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:58515"/>
            <dbReference type="ChEBI" id="CHEBI:58929"/>
            <dbReference type="EC" id="4.2.1.108"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 7">Amine and polyamine biosynthesis; ectoine biosynthesis; L-ectoine from L-aspartate 4-semialdehyde: step 3/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the ectoine synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.108" evidence="4 7"/>
    <dbReference type="EMBL" id="NNBL01000002">
        <property type="protein sequence ID" value="PJN12876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN12876">
        <property type="protein sequence ID" value="PJN12876"/>
        <property type="gene ID" value="CG723_07640"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00067">
        <property type="reaction ID" value="UER00123"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033990">
        <property type="term" value="F:ectoine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019491">
        <property type="term" value="P:ectoine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06978">
        <property type="entry name" value="cupin_EctC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01255">
        <property type="entry name" value="Ectoine_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010462">
        <property type="entry name" value="Ectoine_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39289">
        <property type="entry name" value="PTHR39289"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06339">
        <property type="entry name" value="Ectoine_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0456">Lyase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00019707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00033271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PJN12876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="132" mass="15145" checksum="BB94468FDDB78238" modified="2018-04-25" version="1">MIVRSFKEIENTDRHVKSATGTWESKRIVLAKEKVGFSLHETILYAGTETDMWYANHIEAVLCVEGEAELTNKETGEKHWIEPGTMYLLNGHERHTLRPKTDFRCVCVFNPPVTGREDHDENGVYPLLTEEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K1A5</accession>
    <name>A0A2M9K1A5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alkaline shock response membrane anchor protein AmaP</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_07815</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000002">
        <property type="protein sequence ID" value="PJN12904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN12904">
        <property type="protein sequence ID" value="PJN12904"/>
        <property type="gene ID" value="CG723_07815"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="63"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN12904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="195" mass="21102" checksum="B6CE3A4873184794" modified="2018-04-25" version="1">MSPVLRTVNRVVVGLVGLILVVIGGSVLAVGLGAPPPSWWIYDGRHDVLLSKADRYRWRDDGWWWPVVIAAIAVCVLLALWWLVAQLRRRRLTEVLVDTGDGEGALLRGRALEGVLASEAESLDGVERAGVVLTGRRSAPQVRMGLLLEPHAEPGAALQQISEEALGHARDSAGLAALPAEVRLRAVKHRAERVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K1G6</accession>
    <name>A0A2M9K1G6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CG723_04785</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000002">
        <property type="protein sequence ID" value="PJN12968.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN12968">
        <property type="protein sequence ID" value="PJN12968"/>
        <property type="gene ID" value="CG723_04785"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034660">
        <property type="entry name" value="DinB/YfiT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007061">
        <property type="entry name" value="DUF664"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04978">
        <property type="entry name" value="DUF664"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109854">
        <property type="entry name" value="SSF109854"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PJN12968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="181" mass="20103" checksum="012FBD31D98D4B98" modified="2018-04-25" version="1">MTGATYDETGAGEIKALLNALRGQRRHILGIIDGLGPEALRRPVLPSGWSCLGLVQHLALDVERFWFQAVLTGDQPVIDGLDATEDAWQVAPDVPAADVLERYRRETDRADEIITATPADAPLAWWPHHLFGPPHLHSHRDVLLHVITETACHAGHLDAARELIDGRRWLVLTEDREADRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K1K0</accession>
    <name>A0A2M9K1K0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CG723_06725</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000002">
        <property type="protein sequence ID" value="PJN13012.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN13012">
        <property type="protein sequence ID" value="PJN13012"/>
        <property type="gene ID" value="CG723_06725"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006439">
        <property type="entry name" value="HAD-SF_hydro_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041492">
        <property type="entry name" value="HAD_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023198">
        <property type="entry name" value="PGP-like_dom2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13419">
        <property type="entry name" value="HAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01509">
        <property type="entry name" value="HAD-SF-IA-v3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PJN13012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="207" mass="21078" checksum="DED3D35379D22C4C" modified="2018-04-25" version="1">MDGTLVDTEDMWLEVVEAVSVRHGRPLDEEGRAAVLGRSVEDAADLLHESLGAPREDLADELGRDFTARIAEGAPPRPGALGLLAALRAAGVPTALVSASPRAVVRRIAESLDGHVFDAVYGAEDTPRTKPAPDPYLAAAATLGAEPARCVAVEDTPTGVASAEAAGCAVLAVPSVRPIAPAPGRTVVADLTAADVELLRSLVAGAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K1N7</accession>
    <name>A0A2M9K1N7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CG723_00120</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000001">
        <property type="protein sequence ID" value="PJN13052.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN13052">
        <property type="protein sequence ID" value="PJN13052"/>
        <property type="gene ID" value="CG723_00120"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021408">
        <property type="entry name" value="DUF3046"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11248">
        <property type="entry name" value="DUF3046"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PJN13052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="64" mass="7323" checksum="AEF34C702D4A150F" modified="2018-04-25" version="1">MRLTVFWQRMADHFGPGYAETFARDHVMTELGGRTVHEALDAGWEAKDVWRAVCATMNVPSENR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K1V8</accession>
    <name>A0A2M9K1V8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Cation acetate symporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CG723_00435</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CB01635</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000001">
        <property type="protein sequence ID" value="PJN13105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN13105">
        <property type="protein sequence ID" value="PJN13105"/>
        <property type="gene ID" value="CG723_00435"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1730.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038377">
        <property type="entry name" value="Na/Glc_symporter_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001734">
        <property type="entry name" value="Na/solute_symporter"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00474">
        <property type="entry name" value="SSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50283">
        <property type="entry name" value="NA_SOLUT_SYMP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="79"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="121"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="159"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="189"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="247"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="281"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="340"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="387"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="413"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="446"/>
            <end position="467"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU362091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PJN13105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="530" mass="54702" checksum="93A638DABB484580" modified="2018-04-25" version="1">MTGNHQTLALLLFSVFVAVTLAITTWVSHNRHGSAEEFYAGGRLFSPMENGFAIAGDYMSAASFLGISGLIALFGYDGLLYSVGFLVAWLVVLLLVAELVRNCGRFTLADVIAARMRERPVRIAAGTSSVTVSVLYLVAQMVGAGSLVALLLGSTGGAVQAWTVVGVGGLMVVYVSLGGMRATTWIQIVKAVLLMGGAIVLTVLVLVRFHGDFDQLLRTAAQRSGHGAAFLAPGLKYGGDWTARLDFISLGLALVLGTAGLPHILSRFYTVPTARAARRSVIWSIGLIGSFYLMTIVLGFGAAAIVGSGAVRGSNAAGNTAVPLLALDLGGGPDSTGGTVLFAVVAAVAFATILAVVAGITLASSASVAHDLYASLRRPHAKPRSEVAVARVAAAGIGVVAIALGLLARDLNVAFLVGLAFAVAASANLPVLLYSLFWRNFTTRGAVWSVYGGLVPALVLVVLSPVVSGSETSLFPGVDFQYFPLENPGLVSIPLGFLAGWLGTVTSHEPPDEAKHAETEVRALTGAGAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K260</accession>
    <name>A0A2M9K260_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">UDP-N-acetylglucosamine 1-carboxyvinyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_01030</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000001">
        <property type="protein sequence ID" value="PJN13205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN13205">
        <property type="protein sequence ID" value="PJN13205"/>
        <property type="gene ID" value="CG723_01030"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016765">
        <property type="term" value="F:transferase activity, transferring alkyl or aryl (other than methyl) groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.65.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001986">
        <property type="entry name" value="Enolpyruvate_Tfrase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036968">
        <property type="entry name" value="Enolpyruvate_Tfrase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013792">
        <property type="entry name" value="RNA3'P_cycl/enolpyr_Trfase_a/b"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00275">
        <property type="entry name" value="EPSP_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01381">
        <property type="entry name" value="HTH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55205">
        <property type="entry name" value="SSF55205"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="2">
        <location>
            <begin position="13"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN13205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="509" mass="55961" checksum="8D46C37C5E28A9DD" modified="2018-04-25" version="1">MADDYLVRIGKLIRDARQHRGWTQSQLAEALGTSQSAVNRIERGNQNISLEMIARIGEALDSEIVSLGYSGPMHLRVVGGRRLSGSIDVKTSKNACVALLCASLLNRGRTVLRRVARIEEVYRLLEVLNSIGVRTRWINGGVDLEIVPPAALDMDAIDAAAARRTRSIIMFFGPLLHRLNHFKLPYAGGCDLGTRTIEPHMIALRRFGLDITATEGLYHAQVEAGVSPGRPIVLTERGDTVTENALLAAARHDGTTVIRNASSNYMVQDLCFFLEALGVRVEGIGTTTLTVHGVPQIDVDVDYSPSEDPVEAMSLLAAAVVTESELTVKRVPIEFLEIELAVLEEMGLDHDRTAEYFADNGRTRLVDLTVRPSKLEAPIDKIHPMPFPGLNIDNVPFFAAIAAAAQGQTLIHDWVYDNRAIYLTDLNRLGGRLQLLDPHRVLVEGPTRWRAAEMMCPPALRPAVVVLLAMMAAEGTSVLRNVYVINRGYEDLAERLNSVGAQIETFRDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K298</accession>
    <name>A0A2M9K298_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">TIGR04222 domain-containing membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_01235</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000001">
        <property type="protein sequence ID" value="PJN13243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN13243">
        <property type="protein sequence ID" value="PJN13243"/>
        <property type="gene ID" value="CG723_01235"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026467">
        <property type="entry name" value="Ser/Gly_Cys_C_dom"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04222">
        <property type="entry name" value="near_uncomplex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014896388" evidence="2">
        <location>
            <begin position="29"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="147"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="173"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN13243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="256" mass="26128" checksum="23F12F2E050ECF88" modified="2018-04-25" version="1">MFWLLFLLMACAAAFLSCARLCLAAVHAAHGEPAGGGAHELTLYEAAFLSGGPFRVADLTLVSMARSRRLLLAHTGWATVVDPVGGDDIERSVIGAIGPDGQSRIGAVRRATAAADAVRALADRLVAAGLAVPDGARGGVAAAVRQVRAAALAVVVLAAVSLTMPGGEPGDGVLIAAWFALPLILTLSCLAIARFEVHPYTRWASPTGQRLIGALPRGVREGVGEAALLTAVAVHGVRAVSDPALRSAFGTAQRGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K2B3</accession>
    <name>A0A2M9K2B3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CG723_01415</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000001">
        <property type="protein sequence ID" value="PJN13274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN13274">
        <property type="protein sequence ID" value="PJN13274"/>
        <property type="gene ID" value="CG723_01415"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PJN13274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="153" mass="16742" checksum="A0D2A292491D7BF4" modified="2018-04-25" version="1">MTTNRGRKHVIRSRMTSTGESYVVAAKNLKAMKDMGATAEAVRTQRWRPAESLDVPCPCGGTCEPGEKCDRCHARHRHVGRAPGSLTDVETWMDKYDCMGCASSYTLTVVLPGRPWGIAETVVQGGSTEPVVRARVFPGVVHPMMRPETPAED</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K314</accession>
    <name>A0A2M9K314_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CG723_02810</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CB01635</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LytR/CpsA/Psr (LCP) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000001">
        <property type="protein sequence ID" value="PJN13512.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN13512">
        <property type="protein sequence ID" value="PJN13512"/>
        <property type="gene ID" value="CG723_02810"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027381">
        <property type="entry name" value="LytR/CpsA/Psr_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004474">
        <property type="entry name" value="LytR_CpsA_psr"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13399">
        <property type="entry name" value="LytR_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03816">
        <property type="entry name" value="LytR_cpsA_psr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00350">
        <property type="entry name" value="lytR_cpsA_psr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="33"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="domain" description="LytR_cpsA_psr" evidence="4">
        <location>
            <begin position="108"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="domain" description="LytR_C" evidence="5">
        <location>
            <begin position="387"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="358"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="472"/>
            <end position="508"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF03816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF13399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PJN13512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="508" mass="53126" checksum="989AA4C33D75E8A7" modified="2018-04-25" version="1">MAGTREQLTPARRGGGAKSPARAARPRRSRVRFTLAIALSLLVLLTGGVGWLYLKLGGDINTFSSDGISGDRPDADASQGENVLVIGSDARTGGNEALGGGDKGDIGRSDTTFLLHVYADHRNAVAVSVPRDTLVTIPPCKLPDGSWTSNRPDTMFNAAYSTGETAGGNPACTQNTVEKLTGLRVDHTVVVDFKGFAALTDVVGGVKVCLPQAIYQRDLNPHRTTPGKLLFPRGEQSVSGQKALDYVRLRHGIGDGSDIGRIKRQQAFVGSLIKEIKSNGLTPTKLLPLANAATRSMTVDPGLGSADKLLSFAMSLKNVDLHNTKFVTIPWRYEGSRVAVVEPDADALWASLREDRTLDGKDASGKKGAGPSASPASSAAPDPGDGIRVTVYNGTTVMGLAAQAARALEDDGFTVTGTATANTRNQATTLIQYGPGEKTRAGTLAQRFPGARLEETSTAGIKAILGQDYADHPSTAATASPEPTGIPSDVSDDARSADDSLCSNLSYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K343</accession>
    <name>A0A2M9K343_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CG723_02975</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000001">
        <property type="protein sequence ID" value="PJN13539.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN13539">
        <property type="protein sequence ID" value="PJN13539"/>
        <property type="gene ID" value="CG723_02975"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018170">
        <property type="entry name" value="Aldo/ket_reductase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NADP_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43827">
        <property type="entry name" value="PTHR43827"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000097">
        <property type="entry name" value="AKR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="SSF51430"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00062">
        <property type="entry name" value="ALDOKETO_REDUCTASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00063">
        <property type="entry name" value="ALDOKETO_REDUCTASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldo_ket_red" evidence="4">
        <location>
            <begin position="31"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="1">
        <location>
            <position position="64"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="122"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Lowers pKa of active site Tyr" evidence="3">
        <location>
            <position position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PJN13539.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="290" mass="31667" checksum="81CB467229BB4D47" modified="2018-04-25" version="1">MGVPTDNAKDRELVSKVPPIILNNGVEMPQLGFGVWQVPDAEAEKAVATALEAGYRSIDTAAIYGNEEGTGKAIAASGIAREKLFVTTKLWNADQGYDATLRAFDASLDKLGLDYLDLYLIHWPLPSKDSYVDTYKAFEKIYADGRAKAIGVSNFLPEHLERLLGETSIIPAVNQIELHPHLQQRAAREFHAEQGIATEAWSPLGQGKGLLDVPAIVAIAQKHGRTPAQIVLRWHVQHGNVVIPKSVTPSRIVENIDVFGFELDVEDIAAISALNEDRRLGPDPATFDMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K3E3</accession>
    <name>A0A2M9K3E3_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF2510 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_03020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000001">
        <property type="protein sequence ID" value="PJN13547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN13547">
        <property type="protein sequence ID" value="PJN13547"/>
        <property type="gene ID" value="CG723_03020"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.115.10.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018929">
        <property type="entry name" value="DUF2510"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023296">
        <property type="entry name" value="Glyco_hydro_beta-prop_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10708">
        <property type="entry name" value="DUF2510"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF2510" evidence="1">
        <location>
            <begin position="267"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF10708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN13547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="416" mass="44498" checksum="E96B45093FBDA6E9" modified="2018-04-25" version="1">MPADTEAVRRRSLGAGLGLLLALVCAAALLTALPDDDREGGRPCAARGIASWSAEPGLTGAFARYGDDASRDDDWTGGDGTHSVRLPDGRVLWLFSDTYLGQVHAPPNPAGQPHAWRDMSAPFVRNSAVVMGRSGTLERTLPAPLFPDPAPQQWRWPVAARVEPRSPGSAERVVRVLLWTRTTGTGPWIYGMPAATEVATLSLPGLRVESVATVLDQRGVPDPARRVLFGTTVVDRGGRTYVFGGDDGQGVTRRAYVARVPRGRLAEPGAWRYWDGSRWTRAARPRAVLGDGARRGVGSAFTVVRDGGTYVLFTMAAGTAGLTRVTSYWACAPTGPWHGPGKGFEAPLPPDGALRQDTAAYNPQAHPALGGGDGRLLLSYDVNWLDAAPATAQAQVSRNVSLYRPRFVALRLARPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K3I0</accession>
    <name>A0A2M9K3I0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CG723_03830</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000001">
        <property type="protein sequence ID" value="PJN13683.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN13683">
        <property type="protein sequence ID" value="PJN13683"/>
        <property type="gene ID" value="CG723_03830"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="SSF54427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PJN13683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="141" mass="15731" checksum="74ECA26D9849BAEF" modified="2018-04-25" version="1">MPHIDAQELAGRYAAVWNERDPELRRKAVHALWSPDGVHALLPPRELQETAVRLGFPTAALEARGHDELEARVTRAHEEFVATGEYTFRATAAHAQQLNDVVTFRWESVITRSGEVTGGGLEFVVVAQDGRIVRDYQFVGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-09-29" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JEJ7</accession>
    <name>A0A2M9JEJ7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CG723_45425</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CB01635</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000054">
        <property type="protein sequence ID" value="PJN05320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN05320">
        <property type="protein sequence ID" value="PJN05320"/>
        <property type="gene ID" value="CG723_45425"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="51"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="86"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="111"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="144"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="180"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="245"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="277"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="312"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="335"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="367"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="403"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="20"/>
            <end position="428"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PJN05320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="448" mass="46095" checksum="3976C534E6F18EB5" modified="2018-04-25" version="1">MSTRQTDMRDQAARKVMAHLIPLLVVVYFAASIDKANIAMAKDSLGADIGLSAAAYGLGAGIFFISYMLLEIPSNLVLHKVGPRWWIGRISVTWGVITAAAMFVHDEWTFYLARVLLGAAEAGLYPGLMYLVSVWLPQPKRAKAVGLLLASATAAGLVGAPIGSGLLYLDGTVGLHGWQWMFLIEGGASVLIGIVVWMRLPSRPEDARWLRAEEASALAEAAAERGPTEPVPASTITTSLTNPTVLISAALYLLLQAALSGPVFFGPAMVEDMGVSGTAAIGGVVALITLGPLLGVLLLPRIYRRTGAGSEWTLIAGSMSAALAASLALPSAHGVIAQALLLGIAMLLVMGIATVVWAFAMTATSGIGAAAALAAVNSIGALGAFAGPFAFGHIEQSTGSALNGMYLVAALAAAIGALTPLVRSRHRSTASASAGTTRVNLSGIAETD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-09-29" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JEY1</accession>
    <name>A0A2M9JEY1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_45500</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000056">
        <property type="protein sequence ID" value="PJN05307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN05307">
        <property type="protein sequence ID" value="PJN05307"/>
        <property type="gene ID" value="CG723_45500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="29"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="77"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="107"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="137"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="162"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="205"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="237"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="277"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="350"/>
            <end position="381"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN05307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="404" mass="41742" checksum="B9F7931EBEE3428D" modified="2018-04-25" version="1">MAGDNGPERVLIGASFVNRVGNGLFNAAAALYFTLVVGLPAVQVGAALTIGGVIGLCTGIPGGHLADRRGARSIMMLALTVQAMSMAALLVVESWGALTIIATVDQMAAAAGGAAWGALVVRVGGDRPALFRARLRTFVNLGVFLGTVGAGLALAADTRGAYVTLILGNAASFALCAVFLLLLPRYPVLAAPPQRRRWLAFTDRPFLTFTALYGAMGLQYPVVSLLLPIWISEHTEVPRWTVAALFAVNAAFCVLMQTRIGSRIETLHDGGRAFRTAGLLFLVSCPMMALAAYTPVWAAAGLVLAAIFVHSLGEVWESSAGFALGFGLAPDHAQGQYQGVLGLGFSAGQALAPAILTTVVLGLGAAGWLMLALFFAALGAVGPSLARWGTRTRPQPGVTAEGTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JF13</accession>
    <name>A0A2M9JF13_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HpcH_HpaI domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_44345</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000047">
        <property type="protein sequence ID" value="PJN05478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN05478">
        <property type="protein sequence ID" value="PJN05478"/>
        <property type="gene ID" value="CG723_44345"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005000">
        <property type="entry name" value="Aldolase/citrate-lyase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_Kinase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040442">
        <property type="entry name" value="Pyrv_Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03328">
        <property type="entry name" value="HpcH_HpaI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="SSF51621"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HpcH_HpaI" evidence="1">
        <location>
            <begin position="29"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN05478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="257" mass="27188" checksum="85E47E22175515A9" modified="2018-04-25" version="1">MRENRTKRQLSEDRPAFGVSLTIPDVFVAETIGAGGFDFVMIDTEHAPIPIDALQAMLVALRASRSTLFVRSPANDTALIGQILDVGAEGVIVPGVQNAAECAAAVAATRYPPAGVRGFGPRRAARLDGGRAEYIARADEEIAAFVMIEHADAVADIDAILKTPGLDGIMVGPADLAVSMGHLHDLDHPGVRAAIDRVFAACERHSVPFGIFAPSEQAARLWVRRGARFMAVGGDVQFLSQGIAHTKTLVASLNDSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JF32</accession>
    <name>A0A2M9JF32_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Mycofactocin biosynthesis peptidyl-dipeptidase MftE</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">mftE</name>
        <name evidence="6" type="ORF">CG723_44450</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CB01635</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the creatininase superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000047">
        <property type="protein sequence ID" value="PJN05498.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN05498">
        <property type="protein sequence ID" value="PJN05498"/>
        <property type="gene ID" value="CG723_44450"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10310">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024087">
        <property type="entry name" value="Creatininase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003785">
        <property type="entry name" value="Creatininase/forma_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023871">
        <property type="entry name" value="MftE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35005">
        <property type="entry name" value="PTHR35005"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02633">
        <property type="entry name" value="Creatininase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102215">
        <property type="entry name" value="SSF102215"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03964">
        <property type="entry name" value="mycofact_creat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="240"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="261"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00024029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PJN05498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="278" mass="29228" checksum="E691051C6BFF8626" modified="2018-04-25" version="1">MPRQHDSSALELGRAVWPEITGRPMVLVPVGATEQHGPHLPLNTDTVVATAVAREAVQRLADRDHAEGSPDARVILAPALAFGASGEHAHFPGTVSIGHEALRVVLIETVRSLSLWAGRCVFINGHGGNVATLDGAVAQLRAEGHDIAWLGCVVHGGDAHAGRTETSLMLHLAPDDVRLDAAAAGETRPIAELMPELAARGVRAVAPNGVLGDPSGASAQEGRVLLRNLVDTAVRRIQAWRPDPRGRLGEPSAPSPPPADRRTVAEHRAPTASDRSRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-05-25" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JFB0</accession>
    <name>A0A2M9JFB0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">LacI family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CG723_44040</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000045">
        <property type="protein sequence ID" value="PJN05591.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN05591">
        <property type="protein sequence ID" value="PJN05591"/>
        <property type="gene ID" value="CG723_44040"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01392">
        <property type="entry name" value="HTH_LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000843">
        <property type="entry name" value="HTH_LacI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046335">
        <property type="entry name" value="LacI/GalR-like_sensor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00356">
        <property type="entry name" value="LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13377">
        <property type="entry name" value="Peripla_BP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00036">
        <property type="entry name" value="HTHLACI"/>
    </dbReference>
    <dbReference type="SMART" id="SM00354">
        <property type="entry name" value="HTH_LACI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50932">
        <property type="entry name" value="HTH_LACI_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH lacI-type" evidence="5">
        <location>
            <begin position="36"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="20"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PJN05591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="362" mass="37928" checksum="B1B5BF0B26AA1E64" modified="2018-04-25" version="1">MHRDRGAGLTTSRASDATGRKSDTTGKKGASGRRRVTITDVGTAAGVSTSTVSRVLNGTARVDPDLAARVQGAVAELGYRPNAAARGLARGETDAVGVLVPDLSNPYFPDLLKAVSAVARSHGRRVMVMESDEDPASEHELAEDLMRCCDGVLLCSPRMERAALVDLPLRDHPVVLVNRIVPGLSVPSVSVDFYGGMTLACGHLTQLGHRRVAYLSGPEASWANAERIRAFDAAAAFGLDVTVIPCGHTAKHGYAAADGVQAAGVTAVVAYNDLVALGALTALEESGLRVPEDMSVIGCDDISLDDLPSSRRLTTASLARHELGRQATEMLEALMADGGDSEPRYIPMELLVRGTSAPPARG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JFQ6</accession>
    <name>A0A2M9JFQ6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CG723_43055</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000042">
        <property type="protein sequence ID" value="PJN05711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN05711">
        <property type="protein sequence ID" value="PJN05711"/>
        <property type="gene ID" value="CG723_43055"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000835">
        <property type="entry name" value="HTH_MarR-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041678">
        <property type="entry name" value="TetR_C_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12802">
        <property type="entry name" value="MarR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17920">
        <property type="entry name" value="TetR_C_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00598">
        <property type="entry name" value="HTHMARR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00347">
        <property type="entry name" value="HTH_MARR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50995">
        <property type="entry name" value="HTH_MARR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="3">
        <location>
            <begin position="61"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="domain" description="HTH marR-type" evidence="4">
        <location>
            <begin position="271"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="84"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="24"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PJN05711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="413" mass="43975" checksum="F771A9317E2D7157" modified="2018-04-25" version="1">MLRTGTSAVAGDGDGPGGRPPRPARTPHSEHSFNLRHVDAEHSTPDRTAPEPRRGRSHDPEGRRSAVLEAARRLFAAQGYKGVGIRAIAAEAGVTPGLVMAYFGSKDGLFREVVGGGTGVTEGVLDDPSVGREELPRALAHDYLDRWDRLPAHDPWPALIRSGLSHPPSAELLSTILDRQVSEPLRRLLGDCDAADARIAMIRSILFGVIMERYLFAHEPATSVPTGTLEPVLADVLTAALTGRVPERRAPEPDPAAAPRPLVREAPGASGPAVFAALNACTAHYRTLIGRVVKRHGISLAAFEVLSALHATSAPYQRTMGEIAAAGAVSAGGVTQQADRLVEAGLIERERDGQDRRIVHLRLTPAGADLVGRVAEERRAHERELLAGLVPGEQRQLAALLDGLGRSMKAEQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-09-29" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JFX4</accession>
    <name>A0A2M9JFX4_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">AAA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_42895</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000041">
        <property type="protein sequence ID" value="PJN05781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN05781">
        <property type="protein sequence ID" value="PJN05781"/>
        <property type="gene ID" value="CG723_42895"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043531">
        <property type="term" value="F:ADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002182">
        <property type="entry name" value="NB-ARC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00931">
        <property type="entry name" value="NB-ARC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA" evidence="2">
        <location>
            <begin position="46"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="652"/>
            <end position="679"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN05781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="679" mass="73275" checksum="44FBCD8990ABE399" modified="2018-04-25" version="1">MTDQAVEPKDGLKNSQFLGRSRELKELRADIERAGLDTIAGRKAPRARVLLIAGRPGSGRTALAEELLSQVAAGYPDGILRTRLTAPDGTRVPTERTARELLDSLDLPAPPGEGEDDLAERLREGLSVRRAVLFLDDATDAEQVDPLLPETPDCLVVAVSEGPLTGISDVRPCTLGGLDTKSALELLGRHTGSVRITVDPRSAESLVEECGSQPAALMLAGGWLAVRPKEAVADLAKQLHAQADDGPPLARVFQHAYASLPVPAARILRYLSLAPEGHVDPHTASALAGCSVSAARTTLDDFTVLGLVGRIDSELPQYEVPGCLMPLLRGLTEAHDRPGEVQLARARMLERTVRLLQSCRAITEPEGSPARKKLAGLPRALRFPNPAAGAEWLRVRRPALLAAARLAVADGELDTLARRLMAALTRALAVHVGTEAAAPDLYGIHRLVLDVAERRKLPREKAAALLNLADLDARTGRTQEALTRYRAALDAGREARDPYATGRAMESVGGTYQELGDWHRAADWYGRALAQRLTRGERADAARLHGRIGTVNTYAGRYGDALRSWRSAAAGYRKEGDVAAQARALSEMARVQEYAGRPEESLRTCHEAVEWARQAKDVRLQAALQLRLADTLDRLGDPAAAKLHRGAAERMLGEELPIEGKTPEQGADTYEIRSASEED</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JFZ7</accession>
    <name>A0A2M9JFZ7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Multidrug ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CG723_42480</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000040">
        <property type="protein sequence ID" value="PJN05811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN05811">
        <property type="protein sequence ID" value="PJN05811"/>
        <property type="gene ID" value="CG723_42480"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="8"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="41"/>
            <end position="48"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PJN05811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="323" mass="35177" checksum="B63FA9A54A869865" modified="2018-04-25" version="1">METNERVIDVTDLRRVYGGSYEAVRGVTFSVARGELFALLGTNGAGKTSTVELLEGLAVPAGGRVRVLGHDPYTERDLVRPRVGVMLQEGGFPSELTVAEAVRMWGGCTSGARPAGEALELVGLERRSRVRVKQLSGGEKRRLDLALALLGRPEVLFLDEPTTGLDAEGRRATWNLVRELRAEGTTVLLTTHYLEEAEELADRLAILHEGRIAAEGRVDEVVAAQPSHISFELPDGYFPGDLPPLAELGVSGHETDGRTIRLRTGELQRAATGLLLWARDARVELRGLDVRSASLEEAFLRIAQDARTETMAGTEHRDEVAAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JG25</accession>
    <name>A0A2M9JG25_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_43030</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000042">
        <property type="protein sequence ID" value="PJN05707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN05707">
        <property type="protein sequence ID" value="PJN05707"/>
        <property type="gene ID" value="CG723_43030"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010419">
        <property type="entry name" value="CO_DH_gsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38588">
        <property type="entry name" value="PTHR38588"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06240">
        <property type="entry name" value="COXG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="180"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN05707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="209" mass="21968" checksum="8B17E74FAA915741" modified="2018-04-25" version="1">MRLDHSFTVPAAPDDAWKLFLDLGRVAPCMPGAVLDTLDGDAFTGRVKVKVGAVQMSYRGEGTVTRDESGRSMVLDLSGSETRGAGTASATVTASLTADPAGTRVRVSTDLDITGRPAQFGRGIMTEVGDRIVRQFADRLEELLREPATMEPAAALSSPAREPEAVDLGAAALPVLLRKAAVPAVAVLVTIAVIRLFARRASTPRSLQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-05-25" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JGG8</accession>
    <name>A0A2M9JGG8_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Phosphoribosylamine--glycine ligase</fullName>
            <ecNumber evidence="6">6.3.4.13</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">GARS</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Glycinamide ribonucleotide synthetase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Phosphoribosylglycinamide synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">purD</name>
        <name evidence="9" type="ORF">CG723_42440</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CB01635</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>5-phospho-beta-D-ribosylamine + ATP + glycine = ADP + H(+) + N(1)-(5-phospho-beta-D-ribosyl)glycinamide + phosphate</text>
            <dbReference type="Rhea" id="RHEA:17453"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:58681"/>
            <dbReference type="ChEBI" id="CHEBI:143788"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.4.13"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 6">Purine metabolism; IMP biosynthesis via de novo pathway; N(1)-(5-phospho-D-ribosyl)glycinamide from 5-phospho-alpha-D-ribose 1-diphosphate: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the GARS family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.13" evidence="6"/>
    <dbReference type="EMBL" id="NNBL01000040">
        <property type="protein sequence ID" value="PJN05847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN05847">
        <property type="protein sequence ID" value="PJN05847"/>
        <property type="gene ID" value="CG723_42440"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00125"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004637">
        <property type="term" value="F:phosphoribosylamine-glycine ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009113">
        <property type="term" value="P:purine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.600.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00138">
        <property type="entry name" value="GARS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020561">
        <property type="entry name" value="PRibGlycinamid_synth_ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000115">
        <property type="entry name" value="PRibGlycinamide_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020560">
        <property type="entry name" value="PRibGlycinamide_synth_C-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037123">
        <property type="entry name" value="PRibGlycinamide_synth_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020559">
        <property type="entry name" value="PRibGlycinamide_synth_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020562">
        <property type="entry name" value="PRibGlycinamide_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011054">
        <property type="entry name" value="Rudment_hybrid_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43472">
        <property type="entry name" value="PTHR43472"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01071">
        <property type="entry name" value="GARS_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02843">
        <property type="entry name" value="GARS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02844">
        <property type="entry name" value="GARS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01210">
        <property type="entry name" value="GARS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51246">
        <property type="entry name" value="SSF51246"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="SSF52440"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00877">
        <property type="entry name" value="purD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00184">
        <property type="entry name" value="GARS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 6 9" id="KW-0436">Ligase</keyword>
    <keyword evidence="3 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4 6" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-grasp" evidence="8">
        <location>
            <begin position="107"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PJN05847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="417" mass="42529" checksum="BD92241F6E15D6F6" modified="2018-04-25" version="1">MKVLVIGSGAREHALCRSLSLDPDVTALHCAPGNAGIAEVAELLPVDALDGAAVARLAGELAADLVVVGPEAPLVAGVADAVRAAGIPCFGPSGEAAQLEGSKAFAKDVMAGAGVPTARSYVCTTPAEVDEALDAFGAPYVVKDDGLAAGKGVVVTDDLEAARAHANACDRVVIEEFLDGPEVSLFAITDGVTVVPLQPAQDFKRALDGDAGPNTGGMGAYSPLPWADPKLVDEVMETVLQPTVDELRRRGTAFSGLLYAGLAITSRGVRVIEFNARFGDPETQVVLARLKTPLAGVLLASADGTLADLPPLRWSDEAAVTVVVASHNYPETPRTGDPITGLADVAAQDAPHAYVLHAGTKRDGGAVVSAGGRVLSVTATGSDLTQARERAYAAVSRIGLDGSQHRTDIAAKAAAEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JGP3</accession>
    <name>A0A2M9JGP3_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Tautomerase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_42115</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000038">
        <property type="protein sequence ID" value="PJN05927.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN05927">
        <property type="protein sequence ID" value="PJN05927"/>
        <property type="gene ID" value="CG723_42115"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006725">
        <property type="term" value="P:cellular aromatic compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.429.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004370">
        <property type="entry name" value="4-oxalocrotonate_tautomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014347">
        <property type="entry name" value="Tautomerase/MIF_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01361">
        <property type="entry name" value="Tautomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55331">
        <property type="entry name" value="SSF55331"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tautomerase" evidence="1">
        <location>
            <begin position="2"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN05927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="61" mass="6876" checksum="AFFF6F68A002FD22" modified="2018-04-25" version="1">MPYIDVKIYDRRLTPESERALIERLTQATVDVFGEDIRAQTWITLTGIPAERWGIAGTPGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JHB9</accession>
    <name>A0A2M9JHB9_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HATPase_c domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_40250</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000033">
        <property type="protein sequence ID" value="PJN06252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN06252">
        <property type="protein sequence ID" value="PJN06252"/>
        <property type="gene ID" value="CG723_40250"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13581">
        <property type="entry name" value="HATPase_c_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HATPase_c" evidence="1">
        <location>
            <begin position="14"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN06252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="172" mass="18941" checksum="C49A7206F8E6967F" modified="2018-04-25" version="1">MISHPSKHCTVELQALPSRIRQVRRIVSAQLRYWHLEPLIDEAMLGVTELLTNVHRHAGPDKMCTVEIELLRDRLTVSVHDHDPHLPQLCDADPLSTCGRGLALVAAVSESWGARPQGEDGKVVWFTLPAPPAALPLPPIPEYRVTDAFPELDSPADRRAARHAPARSAVVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-06-02" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JHC4</accession>
    <name>A0A2M9JHC4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">O-antigen polymerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CG723_40320</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CB01635</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000033">
        <property type="protein sequence ID" value="PJN06265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN06265">
        <property type="protein sequence ID" value="PJN06265"/>
        <property type="gene ID" value="CG723_40320"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007016">
        <property type="entry name" value="O-antigen_ligase-related"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04932">
        <property type="entry name" value="Wzy_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="69"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="102"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="130"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="173"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="267"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="293"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="334"/>
            <end position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PJN06265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="356" mass="35049" checksum="496DCB4ABE922E7E" modified="2018-04-25" version="1">MSSAAGPSAEYERRNVADAAGIVALGACAVWSLITATARAGRPEGVLLAVLAVAAGYACGRISGALLPMAAPCAAAFAGLGLALASPHAVPAPDTGSPLGRTGATAALLALSTGGACCAAWAARRLPVRAALFLLAGGTVAAAAAVGSIAGVTACTGVLLCSLASVMMRHHRGLGLAGLGVMTGLVTGLLLALLKGVLPSGLTASLEGQLTQHRILLWQDALRLAESDPGLGSGPGRFAELSPTVGETLLPDGKPHSAPLQQAAEQGLVGVCLLAAVFCWLLYVLWRSARSTPVVLTAGAALTALAGLATLGNALSFTTVTAGAGLLAGVATARPWGDEPPDSTTAAPVRVRSGRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JHH3</accession>
    <name>A0A2M9JHH3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CG723_39815</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CB01635</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pantetheine 4'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:47942"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Antibiotic biosynthesis.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000032">
        <property type="protein sequence ID" value="PJN06293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN06293">
        <property type="protein sequence ID" value="PJN06293"/>
        <property type="gene ID" value="CG723_39815"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00140">
        <property type="reaction ID" value="UER00205"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043604">
        <property type="term" value="P:amide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017000">
        <property type="term" value="P:antibiotic biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008610">
        <property type="term" value="P:lipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901362">
        <property type="term" value="P:organic cyclic compound biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901566">
        <property type="term" value="P:organonitrogen compound biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030639">
        <property type="term" value="P:polyketide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010071">
        <property type="entry name" value="AA_adenyl_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001242">
        <property type="entry name" value="Condensatn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020802">
        <property type="entry name" value="PKS_thioesterase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001031">
        <property type="entry name" value="Thioesterase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00668">
        <property type="entry name" value="Condensation"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00975">
        <property type="entry name" value="Thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00824">
        <property type="entry name" value="PKS_TE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="SSF47336"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01733">
        <property type="entry name" value="AA-adenyl-dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0045">Antibiotic biosynthesis</keyword>
    <keyword evidence="3 6" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="8">
        <location>
            <begin position="1016"/>
            <end position="1092"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="8">
        <location>
            <begin position="2061"/>
            <end position="2136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="973"/>
            <end position="1024"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1092"/>
            <end position="1119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1571"/>
            <end position="1602"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="2287"/>
            <end position="2319"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="6">
        <location>
            <position position="1053"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="6">
        <location>
            <position position="2096"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PJN06293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="2431" mass="259233" checksum="F918CA7F31594A29" modified="2018-04-25" version="1">MTMLQRSGAQTAATAGPGAAEAGTVPLTEDQLGLLLQHRADPQNSPYNVPLAIDLRGPLDDAALEAALAALVARHPLLSARVCDDDTGSGDGLPFLDVDPARAPRMERRGAARDTGHGPARALLAEARRELDLERDGVLRAVLIAHAPDHHTLLLVVHHLVVDGESTGLLLADLLGAYEYGEVPGAAPAGFGAYVTARAHEAGQDTAAAEEYWRGRLDGADLTVDFPLDTPGADAPREAMVPLDLDAGLWGEINAFSRQHRAGAAAVLLAAYLKALGTYGRQQAPTVGVPLGARTDPRFDRTVGYFVRTLLVRAPAQDPDLTAAAFVGGVQRELARAVDHSRLPFPRIAKLAPGGAAADPFNCTFVLHSWADPGAAADEGVELRGGLRARWRQDVPTPGLGLLTLELYEGGGTLRGRLKYDAARIETATAEAFTEHVCELARQLVRGPDRAVAELDGIGPRARATLDHLNATDHPLDDTDIDTLIRAAAQARPDAVAVEFGDRRWTRRELDARIEGYAAGLVARGVRAGDRVGVLLPRSDEAVAAMLGILRTGAAYVPLDAAHPEARRRHIVDSSGIRLAIVAPDTAGACPAGPQQVPLADLARSGVAAVQGPTSADALHVLYTSGSTGTPKGVQLSHRALVTDVLAAVRHFGIGSDDAMLLKAPFTFDVSAHEMLVALVSGARLVVAPPDAERDPDLLAEAIERHGVTLLHAVPSQLRLLLEAEAFTANRTLRTVVSTGESLPNELRIAFEAAHPARLHNAYGPTETSYSTVFSWGRGDDSFWTRRGEVPIGVPFDNIRAYVLDESLRELPPGAPGELWIGGGTVSDGYVGDPERTADRYRALQVGGRTDTVYRTGDLVRLLPGGALTHLGRLDDQVKINGNRVELGEVRAALMSLPAVQDASVQVSRHARGSLQIVAHVVTRAEVTDVRAALGPLLPSHMVPAHFHRVPGIPVLPNGKTDRRALDQLATQGEPAVEAEPTGPVEPAGPVEPAASPEAATAPAVSAPTAPAPAASAPRADVRSSLPAVRSVWGELLGDVRDDAQFFEAGGDSILAMQMVSRLRREGFTLAMREIYRHPVLADLAAHLDAGAPQPTGEPAAAGAAADVPAAADPTRGSSVSPLAPVQSWFFRHIRTDLHQWNQSVLLELNRPVDPTVLRLAMQAVVAAHPALSARFTADAHGDFSEGHMTGAAPFSAYDPRDVLRERDVTDDGELDAALEEIERSLDPLKGVHVRALLAHDRRRPEDNGLLLVAIHHLVVDGVSWRILLEDLEHALASLSDGTLPALPDEACRYEEWVASLPAVAARPGEADYWRALAAARGEARSLLLTTPAPDEQDIRRVEFSLDPEATTRLIGPLPRKLGLQVHQVMTGAFAQALARWRGTREVTFDVETHGRHGRDDLFRTVGWFTSIHPVVLAAERATDPERWLAQVADGLTGVPDGGVGFGACREFSSDPALRTQLRTLPPALVCFNYYGQADQLSADGGFTMSGRPIPREHSARCERVYGIEVYGIVHGGRLRMGLTWVPSPADGVDEAGVKALVDQMRWVLATLAGADPDAVSAGEITAPGLPAALPAAEPSRAGALPDSSTAGPSAVDPRETVPVTPQQHGLLLDALAHSGSGRYVEQLFWRWYGPLDTERFTAAWQSVFDRETVLRAAFDWDDAPCLVLHDRVTADVVRHPAGSVDWDELMEQDRVRGFDLRVPGLLRATLVDDPDGAGTPSTRVLITFHHVLLDGWSVSVLLQEFYRAYFADGTLPGSERRPDIRDYARWLAEQDTAPAREFWSAAVPAAAPLVRPALPGPATGQSGWSRAEVRLSRPEADRLRSWAAARAATESSALQAVWALLLYRAGGGHGPSPVGFGVTVSGRGIALDSVERLPGLLMNSLPMTIQVDPAHTVPQLLTELRDQALDMAAYEWVSTGQIHEWSGRRADEKLVESLIVFENYPRSSEDLESTLAAHGIRVELPEAAGSQTAFPVTLLAFRDVDGSLVLTAVYDRGRITDADAALLVDQCAGLLRALPDTADESTTVADILAGLSPADLPRMADRTEPVADAAGEAVTWPEGPQTQVVKEAWQAVFGTPVADPGVHFFQAGGHSLLAMRLLRELNLRSGRTLRLDELLAHPRAGELAHLLTQEPRDTTGSGPADVLVPLRPAERPGAGTVHLVHPPGGQVACYAQLAHCYEGPEALVGIRDPRVDDPEPEHLSAEQLAELYLEALRPALDSGERIVLGGFSGGGVIAYEIARRITEEGGRPPLVVMVDAGAPDGELTDADADGSFANQLRAVAEGRAPAPDAEGPGARPSDPDGEQDARTAEPDGSASYLTELAQIAEWMRGDGGGDPVALMRDSVEAVQRYRPGPYAGPVAVLRAGDTGFGKGTDYDESDRFHARAGLGWEDHVEDLAIRVVPGNHVTMLTGENVRALARILASAVRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JHH9</accession>
    <name>A0A2M9JHH9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alkene reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_39425</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000031">
        <property type="protein sequence ID" value="PJN06338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN06338">
        <property type="protein sequence ID" value="PJN06338"/>
        <property type="gene ID" value="CG723_39425"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001155">
        <property type="entry name" value="OxRdtase_FMN_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045247">
        <property type="entry name" value="Oye-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22893">
        <property type="entry name" value="PTHR22893"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00724">
        <property type="entry name" value="Oxidored_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Oxidored_FMN" evidence="1">
        <location>
            <begin position="6"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN06338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="365" mass="39326" checksum="1BA950E9FA224777" modified="2018-04-25" version="1">MTTSRLFETARLGTLTLPNRLVMAPMTRNRATADGVPQPVMATYYAQRATAGLIIAEASTPNAVGQTYANITAIHNEAHVEGWRHVTDEVRAAGGRMFLQLQHGGRIGHPDNSGGLTPVAPSPVPLPDTIHTPTGHQPAVVPKEMTPDDIRSTVADFAEAARKAVAAGFEGVEVHGANGYLLHQFLGQGTNHRTDAYGGTVEGRIRFVVEAVRAVADAIGPERVGLRISPGLTVNGMDEGDTDDIYPALVDALSDLDLAYLHIVFADPDNPLFQDLRKRWTGTLIANPVLPRERLPADGGRHESERLLAAGADLVALGRPFLANPDLVERLRVGAPLNQVRDRYLMYVGGATGYTDYPFLSDSRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JHL6</accession>
    <name>A0A2M9JHL6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Pyridine nucleotide-disulfide oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CG723_39625</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000031">
        <property type="protein sequence ID" value="PJN06370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN06370">
        <property type="protein sequence ID" value="PJN06370"/>
        <property type="gene ID" value="CG723_39625"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PJN06370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="374" mass="40274" checksum="96DEB5ED5A176F45" modified="2018-04-25" version="1">MRDTADVHEVDVVVVGAGQAGLSSAYHLRRAGFEPERDFVVLDHSPRPGGAWQFRWPSLTYGKVHGMHSLPGLELTGADPARPSSEVIAAYFASYEETFDLRVRRPVDVRAVREGGGGPPWTEPVGVLGGGRLLVETSAGTWSTRALINATGTWDRPFWPRYPGQETFRGRQLHTAIYPGPEAFRGQRVIVVGGGASGTQHLMEIAPHAAATTWVTRRPPVFNEGPFDENFGRAAVALVDERVRAGLPPQSVVSVTGLPLNDAIRQARADGVLDRLPMFDRITPSGVEWDDGRRVDADVILWATGFRPAIEHLAPLRLRGPGGGIQAEDTRVVADPRIHLVGYGPSASTIGANRAGRAAVRDIKRLLAGAPVAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-06-02" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JIB8</accession>
    <name>A0A2M9JIB8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_37765</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000027">
        <property type="protein sequence ID" value="PJN06636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN06636">
        <property type="protein sequence ID" value="PJN06636"/>
        <property type="gene ID" value="CG723_37765"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN06636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="47" mass="5758" checksum="63288B4D5FA045D4" modified="2018-04-25" version="1">MRRVTINKPVAKTSTTRRQQQDDAAAERRHDRPEVRKDIRRTWWPDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JIE5</accession>
    <name>A0A2M9JIE5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Acyl-CoA dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CG723_37940</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CB01635</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000027">
        <property type="protein sequence ID" value="PJN06665.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN06665">
        <property type="protein sequence ID" value="PJN06665"/>
        <property type="gene ID" value="CG723_37940"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003995">
        <property type="term" value="F:acyl-CoA dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006089">
        <property type="entry name" value="Acyl-CoA_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="SSF47203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="SSF56645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00073">
        <property type="entry name" value="ACYL_COA_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0274">FAD</keyword>
    <keyword evidence="3 5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA_dh_N" evidence="9">
        <location>
            <begin position="6"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_M" evidence="8">
        <location>
            <begin position="122"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_1" evidence="7">
        <location>
            <begin position="241"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="130"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PJN06665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="395" mass="41634" checksum="EDD44155EAEF309B" modified="2018-04-25" version="1">MNLELSEEQTAVRQLAKDFVAREITPNVVGWDRAEEVDRGIVKKLGDVGFLGLTIDEEYGGSGGDHLAYCLVTEELGRGDSSVRGIVSVSLGLVAKTIQSYGTEEQKREWLPRLTAGEALGCFGLTEPGTGSDAGSLTTRAVRDDGGPSRSSGAESGGDYVINGSKMFITNGTWADVVLLFARSTDAPGHKGVTAFLVPTDTPGLTRRTIHGKLGLRGQATAELVLEDVRVPASAMLGPEGKGFSVAMSALAKGRMSVAAGCVGIAQAALDAAVGYAAEREQFGKSIASYQLVQELISDISVDVDAARLLTWRVADLIDRGEDFATAASKAKLFASEAAVRCANNALQVFGGYGYIDEYPVGKLLRDARVMTLYEGTSQIQKLIIGRALTGVSAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JII5</accession>
    <name>A0A2M9JII5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alcohol dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_38040</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000027">
        <property type="protein sequence ID" value="PJN06678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN06678">
        <property type="protein sequence ID" value="PJN06678"/>
        <property type="gene ID" value="CG723_38040"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="PKS_ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002364">
        <property type="entry name" value="Quin_OxRdtase/zeta-crystal_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01162">
        <property type="entry name" value="QOR_ZETA_CRYSTAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PKS_ER" evidence="1">
        <location>
            <begin position="10"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN06678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="311" mass="32661" checksum="E6E564AC7C55539C" modified="2018-04-25" version="1">MKAISYSGYGGPEVLEYGEAHDPKVGPDAVLVKVRAAAVNPVDWKAREGYLDPVLDAVFPVIPGWDVSGVVVQPGSSVTEFVTGDEVIGYVREDFLSRGTFAEYVAAPVRTLARKPRNLTYEEAAGLPLTGLTAYQVLTGALAVQEGDVVLVHAAAGGVGSIAVQLGRHLGARVIGTASERNHDFLRELGAEPITYGDGLAERVRALAPEGVDAAFDTVGGEALKVSADLLAPGGRLASIADASVVDLGGHYVFVRPDAADLARLADLAEQDVVTVHVDETFPLERAADAQRLSAEGRTRGKIVVTVPWTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JJ59</accession>
    <name>A0A2M9JJ59_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CG723_36740</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CB01635</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="NNBL01000025">
        <property type="protein sequence ID" value="PJN06911.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN06911">
        <property type="protein sequence ID" value="PJN06911"/>
        <property type="gene ID" value="CG723_36740"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="8">
        <location>
            <begin position="13"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="282"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="294"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="42"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PJN06911.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="508" mass="55531" checksum="52E18C3F633174C0" modified="2018-04-25" version="1">MNASGGQLVAGRYELSTLIGQGGMGQVWTAYDQRLDRRVAVKLLRPDRVAGQEADELRRRFVRECRVTAQVDHPGLVTVHDAGTQGEDLYLVMQYVDGADLSDHLAEHDPYPWQWAVSVAAQLCAVLCAVHAVPIVHRDLKPRNVMVKQDGTVTVLDLGVASVLDTDTTRLTHTGSPIGSPAYMAPEQAMGGAVGPYTDLYALGVLLHELLSGDVPFAGSTALGVLHRHLYEPPLPVRRLRPEVPEPLEALVLRLLAKDPQHRPASAQETYEALLPLLPARGVPNGGPLDPTRPFLRPHAPWPDRARTPAPQPAAPTPHTDKPDVAGAVDEVKRLLGEGRITQAVDILGAILPAAAAQHGEHSPVVRTLRKQYAATLMDDGQYRRALPELRRLADERATEAGQADPQSLQFRYEAAQCLEQLGEPAAALAEYRALLPYYENQYATTDVTLPLEVRRRIGHLLLALGDRAAAHDTLVRLLHDAERLHGPGHPFPAEIRRTLQWLGQVRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JK27</accession>
    <name>A0A2M9JK27_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Spermidine synthase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_35105</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000022">
        <property type="protein sequence ID" value="PJN07220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN07220">
        <property type="protein sequence ID" value="PJN07220"/>
        <property type="gene ID" value="CG723_35105"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="253"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN07220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="281" mass="29850" checksum="14D6136F4A5870E7" modified="2018-04-25" version="1">MDEPIPVTRTVDHGTAKLMPDVDRRRAWLLTVDGAPQSYVDLDAPEHLEFEYARRLGHVLDCADEPGKPLDVLHLGGGALTLPRYTAATRPGSRQNVVEADRGLLALVAEHLPVPDGAGITVHGADARTWLESADADSADVLVADVFGGSRVPAHLTTVAYAEAAERVLRPTGVYAANLADGTPFAFLRSQLATFSAVFEHLALIAEPAVLRGRRFGNTVLVASHEELDIAALARRAAADAFPARVEHGPQLRRFTGSATPVRDEDAVPSPEPPGGSFGIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JK58</accession>
    <name>A0A2M9JK58_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">VWFA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CG723_35295</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000022">
        <property type="protein sequence ID" value="PJN07255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN07255">
        <property type="protein sequence ID" value="PJN07255"/>
        <property type="gene ID" value="CG723_35295"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00092">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00327">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="SSF53300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50234">
        <property type="entry name" value="VWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="26"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="domain" description="VWFA" evidence="3">
        <location>
            <begin position="386"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="210"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="336"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="226"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PJN07255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="590" mass="61899" checksum="0FB494BCF9AFABC3" modified="2018-04-25" version="1">MGRHSLPDEYGTDAVGPRPRTRGRTVAIATALVLVVAGGTALAARSGLLSFGGACDGKTVHLDIAASPDVAPALRDAADLARKKHLTSDGQCLDTRVQAGDSYKIADSLRKGGKGAGGYEAWVPDSSLWIRRAGLGGNATPVTAMGNIASSPIGISMVPSAAKSMGWPAKQYTWAQLTGAAMEGDKLRLGTADPARSATGLLALTQLGASTKKSGSEGDTQAAAMAKALSQRTTDSDGQLTDTLARDSSGTEQGNPRRNQALFLSEQSSFRYNATAGDKDGLDLFYPKDGSPQLDYPFALVDEGDKSTDERRAAIRFMTLLGEDAGIRILDRHGFRTDDEEPSDAVVAGAGGRTPQPYATSDSEPPTDKELQETLGMWTITVQSARITVVVDASASMANYVPGRNQSRMEVTKASMLQALATFTPEDEIGLWEFATLLDGNRDYRRLVPTERLGDRKGGGTQRDRLSEAFSGLQPVPGGATGLYDTTLAAYEEATSSYRSGKFNALVVVTDGANQDLGSISRSHLVSRLRSLADPQHPVPLIAIAVGPDADKDEVEQIAGATGGSGHQVSDPAQIHAVILKAIVEAGAKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JK74</accession>
    <name>A0A2M9JK74_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">BFN domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_35335</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000022">
        <property type="protein sequence ID" value="PJN07263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN07263">
        <property type="protein sequence ID" value="PJN07263"/>
        <property type="gene ID" value="CG723_35335"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004518">
        <property type="term" value="F:nuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.690.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036104">
        <property type="entry name" value="BFN_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003729">
        <property type="entry name" value="Bi_nuclease_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02577">
        <property type="entry name" value="DUF151"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103256">
        <property type="entry name" value="SSF103256"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51658">
        <property type="entry name" value="BFN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BFN" evidence="1">
        <location>
            <begin position="1"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN07263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="157" mass="17090" checksum="8A8B9278879FFF21" modified="2018-04-25" version="1">MNELDVVGVRVEMPSNQPIVLLREVGGDRYLPIWIGPGEATAIAFAQQGMAPARPLTHDLFKDVLEAVGQELTEVRITDLREGVFYAELVFSSGVEVSARPSDAIALALRTGTPIYGSDGVLDDAGIAIPDEQEDEVEKFREFLDQISPEDFGTNSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-09-29" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JKG1</accession>
    <name>A0A2M9JKG1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CG723_34455</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CB01635</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000021">
        <property type="protein sequence ID" value="PJN07354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN07354">
        <property type="protein sequence ID" value="PJN07354"/>
        <property type="gene ID" value="CG723_34455"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024671">
        <property type="entry name" value="Atg22-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11700">
        <property type="entry name" value="ATG22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="27"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="69"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="105"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="130"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="171"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="201"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="260"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="294"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="325"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="349"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="395"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="417"/>
            <end position="437"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PJN07354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="452" mass="48012" checksum="10765B63F2FFD869" modified="2018-04-25" version="1">MGSDTVRAEPAGDEAAQRRREQRGWYFYDWACSVYSTSVLTVFLGPYLTAVAKSAADADGFVHPLGIPVRAGAFFAYTVSASVIVSILVMPLAGAAADRTGRKKPLLAISAYLGATATAGMFFLDGDRYLLGGLLLVVANASLAVSMVLYNSYLPQIAPPEERDAVSSRGWAFGYASGALVLVANLVLYSGHDSFGVSESTAVRICLASAGVWWGAFTLVPLRRLRDRRTAAADDGAAAVPGWRQLASTVRDMRRRPLTLSFLLAYLVYNDGIQTVISQASVYGSEELGLDQSTLIVAVLLVQVLAVAGALAMGRLARTYGAKNTILGSLIAWTVTIGAGYFLPSGAPVWFFALAAGIGLVLGGTQALSRSLFSHLVPAGKEAEYYSAYEMSDRGMSWLGPLVFGLAYQLTGSYRDAIVSLVAFFMIGFVLLARVPVRQAVRAAGNPVPTRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JKU5</accession>
    <name>A0A2M9JKU5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CG723_33970</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000020">
        <property type="protein sequence ID" value="PJN07496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN07496">
        <property type="protein sequence ID" value="PJN07496"/>
        <property type="gene ID" value="CG723_33970"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PJN07496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="120" mass="13792" checksum="2A4EDE8AD10C8301" modified="2018-04-25" version="1">MKDWADDEYCLYVNGGEASDLWAVLADWTQGEDEEEWKKHIPRFARLIACWQPLGFIRVFRSDEWPAYGAGQEVTGEELTELLTDPRSWAYAEEPTQWICVASGDRPISELEEGMCDEGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-09-29" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JL05</accession>
    <name>A0A2M9JL05_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CG723_32820</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">CB01635</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000019">
        <property type="protein sequence ID" value="PJN07555.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN07555">
        <property type="protein sequence ID" value="PJN07555"/>
        <property type="gene ID" value="CG723_32820"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042597">
        <property type="term" value="C:periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006825">
        <property type="term" value="P:copper ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046688">
        <property type="term" value="P:response to copper ion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032694">
        <property type="entry name" value="CopC/D"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007348">
        <property type="entry name" value="CopC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008457">
        <property type="entry name" value="Cu-R_CopD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014755">
        <property type="entry name" value="Cu-Rt/internalin_Ig-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34820">
        <property type="entry name" value="PTHR34820"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04234">
        <property type="entry name" value="CopC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05425">
        <property type="entry name" value="CopD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="SSF81296"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0186">Copper</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0732">Signal</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014676891" evidence="10">
        <location>
            <begin position="34"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="155"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="187"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="236"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="269"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="308"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="341"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="379"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="domain" description="CopC" evidence="11">
        <location>
            <begin position="32"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="domain" description="CopD" evidence="12">
        <location>
            <begin position="337"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="416"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="486"/>
            <end position="502"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF04234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF05425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PJN07555.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="661" mass="67751" checksum="DD349FCB0C9DFA65" modified="2018-04-25" version="1">MKTIAPRFRHLLLLLLAVTGALLAGAAPVSAHAALTGSDPKQGAVVEQAPTRVSLTFSEEVAMSAGSVRVLDPAGKRVDTGKTTDLGGTTYGVPLHSGLPDGTFTVAYQVVSADSHPVSGAFTFSIGAPSKTTAALPDQTAGGGVVGGLYGVARYLSYGGFILTVGGAAFVLACWPRGAGVRPVQRVVVGGWITLTGATLAMLLMRGSYTGSGAVGDIFDLTLLGQVLQTKSGAALVSRLLLLAAAALFIAVLFGAYEKRTDPKEKKDLTFGLAIGGAVVAAGLAATWAMAEHASTGIQAGLAMPVDVLHLLAVAAWLGGLATLLVALYRAPSIEATAVRRFSRVAFCAVSTLAATGLYQSWRQVGSWSALTGTRYGQLLLLKIGLVAVLVGVAWISRKWTGRLSEGLAPEAAATTVIEERTRSEEAVTVPTGGASKGSSSAEGRRGEAGSGSGGDTGSGAGSDTGSGSDVDDKRSAQLARQRAALTTAREKRIRDADPGRSGLRRSVLTEAGVAVVLLVVTTVLTSTEPGRTEEEAKAVTAAASQRSGPLSLKLPFDTGGQDGKGTLLLDMDPGRTGSNDMHVYVERPNGKAFDVPEVKVSFTLAAKKLGPLPVVPDHIATGHWSASGVQIPVAGDWKIAITVRTSDIDQVTVNKNAKIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-09-29" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JL68</accession>
    <name>A0A2M9JL68_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_33145</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000019">
        <property type="protein sequence ID" value="PJN07613.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN07613">
        <property type="protein sequence ID" value="PJN07613"/>
        <property type="gene ID" value="CG723_33145"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1320">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041916">
        <property type="entry name" value="Anti_sigma_zinc_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="154"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="88"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="176"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="107"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="176"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN07613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="320" mass="33370" checksum="4D4BB94358AB0128" modified="2018-04-25" version="1">MTSTTDTAEHPEIAEISELTEGLLSSSRTEQVREHLNGCELCADVYASLEEIRGTLGTLPGPPHMPADIAGRIDAALAAEALLDTQAPAHTEHEAEAEAEAEAQAASPVSRETTPETTPADSPTAPADRPSGHPRATTGPGRGSRTRNRRRRGAALGAVFTAASIGLGVLLLQNGGSTPTGAPESGTPRQASSALSFSEGKLENQVQSLLTEKSSAPSDSSTSKPSLDIEQSGPKTPRTNSPMRGKTIVVPDCIQRGTGRETPALAIERGDYKGTTAYLVVLPHQSDPAQVSAYVIDATCVKQPSSAPGKLLLTHSYARR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JLB0</accession>
    <name>A0A2M9JLB0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Acyl-CoA dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CG723_32715</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CB01635</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000019">
        <property type="protein sequence ID" value="PJN07661.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN07661">
        <property type="protein sequence ID" value="PJN07661"/>
        <property type="gene ID" value="CG723_32715"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016627">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="SSF47203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="SSF56645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA_dh_N" evidence="4">
        <location>
            <begin position="36"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_1" evidence="3">
        <location>
            <begin position="210"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PJN07661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="368" mass="38171" checksum="6A8287DFF834844F" modified="2018-04-25" version="1">MDFTPTQDQAAAAGLAARIFGDLSTPERLAAAGTGTDPELWKALGSAGLPGAVEETGLLGLVLMLEEQGRTTAQVPFAASCVYGLLAVAGHGTSEQRDRLLPGLRDGTEVATGAFPAQAAVRVAGAEEGEAGEAGTGGGVGRLTGVVPWVPWLRDASWVLVATPDRGLWRVRTADAGCDAVELSAPWSAGRLVLDGAPAERLGGAGAYDDVLAMARTAFAGLQAGVCAGSLARAVEYTNEREQFGRPLAAKQGVQLRAADAYMDTEAIRVTAYEAAWRRDEGLPYAGHALTAAWWASEAGRRVVHAGQHLHGGMGADLEHPVHRHFLWGRQLDAYLGCGGELLAELGDLIAGDDGSGAEGAGMTWVRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JLC4</accession>
    <name>A0A2M9JLC4_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">SSI domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CG723_32680</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CB01635</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protease inhibitor I16 (SSI) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000019">
        <property type="protein sequence ID" value="PJN07658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN07658">
        <property type="protein sequence ID" value="PJN07658"/>
        <property type="gene ID" value="CG723_32680"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004867">
        <property type="term" value="F:serine-type endopeptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.350.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020054">
        <property type="entry name" value="Prot_inh_SSI_I16_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023549">
        <property type="entry name" value="Subtilisin_inhibitor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036819">
        <property type="entry name" value="Subtilisin_inhibitor-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00720">
        <property type="entry name" value="SSI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55399">
        <property type="entry name" value="SSF55399"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00999">
        <property type="entry name" value="SSI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0646">Protease inhibitor</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="5" id="KW-0722">Serine protease inhibitor</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014644121" description="SSI domain-containing protein" evidence="7">
        <location>
            <begin position="25"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="domain" description="SSI" evidence="8">
        <location>
            <begin position="58"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00720"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PJN07658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="148" mass="15225" checksum="D86E66A0E8E4CA15" modified="2018-04-25" version="1">MLRRIALTAAASAAALSAVPAAHADTGPLGLPQLFAEPAVQDQLRVAVTGTGDGRDGTYELECGPSGGTHPEPANACARLDELSANGRDPFAPNSSDSQCTMQYGGPATARVTGTWHGRPVDATYKRTDGCEISRWQGLVPVLPATGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JLL5</accession>
    <name>A0A2M9JLL5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">GntR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_32275</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">In the C-terminal section; belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000018">
        <property type="protein sequence ID" value="PJN07748.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN07748">
        <property type="protein sequence ID" value="PJN07748"/>
        <property type="gene ID" value="CG723_32275"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044249">
        <property type="term" value="P:cellular biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="CDD" id="cd07377">
        <property type="entry name" value="WHTH_GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
        <property type="entry name" value="GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00035">
        <property type="entry name" value="HTHGNTR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00345">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50949">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH gntR-type" evidence="2">
        <location>
            <begin position="4"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN07748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="478" mass="50332" checksum="D4B08FF0BE6238CC" modified="2018-04-25" version="1">MHERSSVGELAERLRGELDRYSPGGKLPSSRALVERFRVSPVTVSRALAQLAAEGLVVTRPGAGAFRAQPRAAAQPAGDTSWQALALSADSATELVPRAVDASGVLVTLSAPPPGVVEFNGGYLHPSLQPERAMAAALARAGRRPGAWGRPPIDGIPELREWFARGIGGAITAAEVLIASGGQSALATALRALAPPGAPVLVESPTYPGMLAIARAAGLRPVPVPVDTDGVRPELLAEAFRATGARVFVCQPLFQNPTGAVLSAQRRPEVLRIAREAGAFIVEDDFVRRLVHEDAGPLPRPLATDDHDGVVVHVCSLTKATSPSFRIGCLAARGPVLERLRAIQVVDHFFVPRPLQEAALELVGSPAWPRHLRTVAAHLKVRRDTMTAALRTTLPELTVGHVPSGGYLLWPRLPDGTDEAALVAGALRAGVAVAPGRPYFSAEPPAPHIRLSFAAIAGPAEITEGVRRLRAACDEVLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JLL8</accession>
    <name>A0A2M9JLL8_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Beta-lactamase2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_32365</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000018">
        <property type="protein sequence ID" value="PJN07765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN07765">
        <property type="protein sequence ID" value="PJN07765"/>
        <property type="gene ID" value="CG723_32365"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008800">
        <property type="term" value="F:beta-lactamase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030655">
        <property type="term" value="P:beta-lactam antibiotic catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046677">
        <property type="term" value="P:response to antibiotic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045155">
        <property type="entry name" value="Beta-lactam_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000871">
        <property type="entry name" value="Beta-lactam_class-A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35333">
        <property type="entry name" value="PTHR35333"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13354">
        <property type="entry name" value="Beta-lactamase2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014883506" description="Beta-lactamase2 domain-containing protein" evidence="1">
        <location>
            <begin position="30"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-lactamase2" evidence="2">
        <location>
            <begin position="127"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN07765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="293" mass="29095" checksum="23CCE69AF8FEE4D2" modified="2018-04-25" version="1">MDRNGLAACAALLAGTLVGTLIGCSPGGAEQPVPVAATASASVPASDEEVSVDRDDALAKALKPLLSDGDARVSVAVAALDGSADGAVYDGASAFDTASIVKVDILAALLLRAQDAGRALTSQERAYATAMIENSDNASATALWDSIGGADGLDAANLTLGLTGTRAGAGGEWGLTQTTAEDQLTLLRAVFSTEGSGLSEASRAYVVGLMGRTAADQRWGVSAAADSVSGCALKNGWLPRTATGLWDINSVGRVTVGGKPYLVSVLSDGNATKEVGVALVEGVATAAVSVLTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JM90</accession>
    <name>A0A2M9JM90_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CG723_31420</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CB01635</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">In the C-terminal section; belongs to the transposase 35 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000017">
        <property type="protein sequence ID" value="PJN07897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN07897">
        <property type="protein sequence ID" value="PJN07897"/>
        <property type="gene ID" value="CG723_31420"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032196">
        <property type="term" value="P:transposition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001959">
        <property type="entry name" value="Transposase_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010095">
        <property type="entry name" value="Transposase_IS605_OrfB_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01385">
        <property type="entry name" value="OrfB_IS605"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07282">
        <property type="entry name" value="OrfB_Zn_ribbon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01766">
        <property type="entry name" value="tspaseT_teng_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0815">Transposition</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014663951" evidence="6">
        <location>
            <begin position="17"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="domain" description="OrfB_IS605" evidence="7">
        <location>
            <begin position="179"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="domain" description="OrfB_Zn_ribbon" evidence="8">
        <location>
            <begin position="301"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="219"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="230"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF07282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PJN07897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="390" mass="43527" checksum="F1D99D3C312366DB" modified="2018-04-25" version="1">MKLVVRVKLLPTHVQAAALEATLYACNQAATWAAGVAFEENARRPLELRKHTYAEFRARWQLGAQAAQHAIKKTCDAYTTLKANLRNGRYGRPGCRRHTRASGKPVVFRPQVAQPYDDRMLSWQYEQQTVSIWSTAGRLKNVAFTGQAGQLEVLAAYRKGESDLVCQGGKWFLIATCDIDEATASTHPVGFLGVDLGIVNIAVTSDGARHCGRRINRKRESDRNLRSKLQKKNTKSAKRRAKKHAGKEARRAKDINHKISKRIVAEAERTGRGIALETLTGIRERARLRKPQRVKIHSWPFAQLGSFIAYKAKQAGVPVVYVDPAYTSQECSQCHHTARGNRPSQAVFSCRVCGFVEHADHNASHNIRQRGWMAWVCGAQSTAPELTLIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JNI6</accession>
    <name>A0A2M9JNI6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CG723_29075</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000014">
        <property type="protein sequence ID" value="PJN08428.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08428">
        <property type="protein sequence ID" value="PJN08428"/>
        <property type="gene ID" value="CG723_29075"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PJN08428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="150" mass="16820" checksum="0E21CE6BC7806356" modified="2018-04-25" version="1">MPVPATIPIAHEPDHRTATIGRYADGQFLATVTYAFPEGYRPDDGWEEHKRLYAVLHTFDASGRYRDSEIWCAGTWAEGAELAQAHAHLDKLLAALPGRTYADIAVRPFRLAVDRVLFGLIAEDDDEGGWAELYPDRLGFGEPWDGRYDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JNJ1</accession>
    <name>A0A2M9JNJ1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Pirin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CG723_29100</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CB01635</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the pirin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000014">
        <property type="protein sequence ID" value="PJN08433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08433">
        <property type="protein sequence ID" value="PJN08433"/>
        <property type="gene ID" value="CG723_29100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012093">
        <property type="entry name" value="Pirin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008778">
        <property type="entry name" value="Pirin_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003829">
        <property type="entry name" value="Pirin_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13903">
        <property type="entry name" value="PTHR13903"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02678">
        <property type="entry name" value="Pirin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05726">
        <property type="entry name" value="Pirin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006232">
        <property type="entry name" value="Pirin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pirin" evidence="3">
        <location>
            <begin position="42"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="domain" description="Pirin_C" evidence="4">
        <location>
            <begin position="201"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF05726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PJN08433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="320" mass="34303" checksum="79741654A9D9A3F1" modified="2018-04-25" version="1">MPAVTVENPLTLPRVAASADAVARPVLAVTTAPSGFEGEGFPVRRAFAGINYKYLDPFIMMDQMGEVEYAPGEPKGTPWHPHRGFETVTYIIDGTFVHQDSNGGGGTITNGDTQWMTAGSGLLHIEAPPEALVMSGGLFHGLQLWVNLPAADKMKDPRYQDIHGGQVKLLTTADGGALLRVIAGELDGHDGPGITHTPITMVHATVRPGAELTLPWREEFNGLAYVLAGRGTVGTDRRPVHMGQTAVFGAGSSLTVRADETQDSNTPDLEVVLLGGRPIREPMAHYGPFVMNTRDELQQAFEDFQAGRLGVIPGERIPHT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JNK4</accession>
    <name>A0A2M9JNK4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CG723_29195</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000014">
        <property type="protein sequence ID" value="PJN08452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08452">
        <property type="protein sequence ID" value="PJN08452"/>
        <property type="gene ID" value="CG723_29195"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024747">
        <property type="entry name" value="Pyridox_Oxase-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12900">
        <property type="entry name" value="Pyridox_ox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PJN08452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="150" mass="16313" checksum="73191D921F173CB6" modified="2018-04-25" version="1">MPSEFQLDRAQEQRAIELIGSVDHGRVATSMRALPFLASARHIVVDGRVVLRMHKGHGYHRACAGSVVAYGADNLNNGDPADGQWSVQFVGTCVAVEPTPGELGLFGPAPRFADGEPFDPVHLRIEPQFVTVHELTGGARHSKRAFRHVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JNW7</accession>
    <name>A0A2M9JNW7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MBL fold metallo-hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_27760</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000013">
        <property type="protein sequence ID" value="PJN08569.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08569">
        <property type="protein sequence ID" value="PJN08569"/>
        <property type="gene ID" value="CG723_27760"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lactamase_B" evidence="1">
        <location>
            <begin position="61"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN08569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="306" mass="33031" checksum="89F04C1565EE1268" modified="2018-04-25" version="1">MKVPIGRPSLRPYLPYQQRTAAHREGLSAHFLGTSSVLLSDGQTSVLSDGFVTRPGMMRVGMGKIAPNRALVRAAIERLRVDNLAAVVCAHSHYDHALDAPVWALETGADLVGSESTANIGRGLGVPESSLRVVGDGDTVTYGSFTLTFLDSVHSPGDHYPGTVDQPLVPPARAGAWKTGTAYSVLVTHPYGRVLLHASANYRLGALRGHHADVVYLGVGMLGKQPAEFLQTYWDEVVAATGARRVILVHWDDFFLGLDRPLRPMPYLLDDLDTTMSRLLLLARRDGVDVVLPVSWQPSAPLTGLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JNX0</accession>
    <name>A0A2M9JNX0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">TetR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_27690</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000013">
        <property type="protein sequence ID" value="PJN08560.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08560">
        <property type="protein sequence ID" value="PJN08560"/>
        <property type="gene ID" value="CG723_27690"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="10"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="32"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN08560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="198" mass="21242" checksum="10F4E97B80E6EA35" modified="2018-04-25" version="1">MGRVSQAQAQENRQRVVATASRMFREKGTAVSVADLMKAAGLTHGGFHKQFASKDDLVDEAIAHAFAEQAAHAAATPEERAGEHEAARRTLIEQYLSVWHRDHAADGCPVSGFAADLGREPDQAARARHVYINGIRNRAARLATGDDDGMAQLCTMVGALALARATRGDPISEELLQAARTALAESGTEQSEPQQRMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JP08</accession>
    <name>A0A2M9JP08_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CG723_28010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000013">
        <property type="protein sequence ID" value="PJN08606.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08606">
        <property type="protein sequence ID" value="PJN08606"/>
        <property type="gene ID" value="CG723_28010"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046267">
        <property type="entry name" value="DUF6300"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19817">
        <property type="entry name" value="DUF6300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PJN08606.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="117" mass="12827" checksum="E11E0239E4BC3289" modified="2018-04-25" version="1">MTAPADENDVIIQLDDMDACRACGEQSVLKASFTQTWTNKRGEAMSGLCEAVLCPECERGTPAADELLALFAVDETLGINNIETFGGLVAAWVESVRHQRVDEARLTEEHEQWSGEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JP75</accession>
    <name>A0A2M9JP75_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GNAT family N-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_26575</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000012">
        <property type="protein sequence ID" value="PJN08666.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08666">
        <property type="protein sequence ID" value="PJN08666"/>
        <property type="gene ID" value="CG723_26575"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013653">
        <property type="entry name" value="FR47"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08445">
        <property type="entry name" value="FR47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="152"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN08666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="295" mass="31256" checksum="7F4992979189AE9F" modified="2018-04-25" version="1">MTESPAPLPGWHLTADVDEFLARAGDYLRAEPALHTVALSVTASLRERGPAVYGARGQLFGVLYGPDGRVSGTFLWTPPFRISVSPLDREQADALAVALQGRPVPGVFGVDAASAAFADAWQSRTGARAHRAVEQRLYRLGDLTPPHPAPAGRHRVATEADRELLVRWRTAFAADAGTPGGASGSAEWADERISYGGVTLWETPDGVPASMAGVTREAAGAVRVAPVYTPEELRGRGYAGAVTAEVSRAARAAGASEVLLFTDLANRTSNGLYLRIGYRPVRDFAVHTFTAPENG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JP76</accession>
    <name>A0A2M9JP76_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">RNA polymerase subunit sigma-70</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CG723_26470</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CB01635</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000012">
        <property type="protein sequence ID" value="PJN08645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08645">
        <property type="protein sequence ID" value="PJN08645"/>
        <property type="gene ID" value="CG723_26470"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039425">
        <property type="entry name" value="RNA_pol_sigma-70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43133">
        <property type="entry name" value="PTHR43133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="6">
        <location>
            <begin position="28"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="173"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PJN08645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="195" mass="21765" checksum="AC5462F8CE3A7409" modified="2018-04-25" version="1">MAKETPTRWDRRMQQRLAHGEAAALGELYDRFASLVHGLAHRVLGDEDAADRITRDVFTHVWENPDAYDPKQGPLRSWIATLTHRRAVHRLRQTESAALVRSGEGTTEDLERKVRHASAAARADYIVTSMPAPLRAALELAYFQRRDYRQTAVDLGVTEDEARRRLRLGLQLLSTAHDSGTSGTPPGSPGHGRAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-05-25" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JPI9</accession>
    <name>A0A2M9JPI9_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">50S ribosomal protein L25</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">General stress protein CTC</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">rplY</name>
        <name evidence="6" type="synonym">ctc</name>
        <name evidence="8" type="ORF">CG723_27320</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CB01635</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Part of the 50S ribosomal subunit; part of the 5S rRNA/L5/L18/L25 subcomplex. Contacts the 5S rRNA. Binds to the 5S rRNA independently of L5 and L18.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the bacterial ribosomal protein bL25 family. CTC subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000012">
        <property type="protein sequence ID" value="PJN08789.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08789">
        <property type="protein sequence ID" value="PJN08789"/>
        <property type="gene ID" value="CG723_27320"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008097">
        <property type="term" value="F:5S rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00495">
        <property type="entry name" value="Ribosomal_L25_TL5_CTC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.120.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.240.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01334">
        <property type="entry name" value="Ribosomal_L25_CTC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020056">
        <property type="entry name" value="Rbsml_L25/Gln-tRNA_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029751">
        <property type="entry name" value="Ribosomal_L25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011035">
        <property type="entry name" value="Ribosomal_L25/Gln-tRNA_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020057">
        <property type="entry name" value="Ribosomal_L25_b-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037121">
        <property type="entry name" value="Ribosomal_L25_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001021">
        <property type="entry name" value="Ribosomal_L25_long"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01386">
        <property type="entry name" value="Ribosomal_L25p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14693">
        <property type="entry name" value="Ribosomal_TL5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50715">
        <property type="entry name" value="SSF50715"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00731">
        <property type="entry name" value="bL25_bact_ctc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 6 8" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3 6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 6" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="Ribosomal_TL5_C" evidence="7">
        <location>
            <begin position="98"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF14693"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PJN08789.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="194" mass="20260" checksum="86706FA6A8082DD6" modified="2018-04-25" version="1">MAEIKLAAEIRTEFGKGAARAVRRENKVPGVIYGHGAEPVHVTLPGHELLLALRTANVLLSLDVDGKTELAIPKAVQRDAIKGYLVHVDLLTVKRGEKVTVEVAVETEGDLAPGSFLVENVLNTLSVETEATHIPTSVTVSIAGLEGGDAIHAKDIALPTGTTLVTDPDAVVIQILAAQAEEPAAETEAEGAEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JPR4</accession>
    <name>A0A2M9JPR4_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Corrinoid adenosyltransferase</fullName>
            <ecNumber evidence="4">2.5.1.17</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Cob(II)alamin adenosyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">Cob(II)yrinic acid a,c-diamide adenosyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">Cobinamide/cobalamin adenosyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CG723_25605</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CB01635</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>2 ATP + 2 cob(II)alamin + reduced [electron-transfer flavoprotein] = 2 adenosylcob(III)alamin + 3 H(+) + oxidized [electron-transfer flavoprotein] + 2 triphosphate</text>
            <dbReference type="Rhea" id="RHEA:28671"/>
            <dbReference type="Rhea" id="RHEA-COMP:10685"/>
            <dbReference type="Rhea" id="RHEA-COMP:10686"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16304"/>
            <dbReference type="ChEBI" id="CHEBI:18036"/>
            <dbReference type="ChEBI" id="CHEBI:18408"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:58307"/>
            <dbReference type="EC" id="2.5.1.17"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>2 ATP + 2 cob(II)yrinate a,c diamide + reduced [electron-transfer flavoprotein] = 2 adenosylcob(III)yrinate a,c-diamide + 3 H(+) + oxidized [electron-transfer flavoprotein] + 2 triphosphate</text>
            <dbReference type="Rhea" id="RHEA:11528"/>
            <dbReference type="Rhea" id="RHEA-COMP:10685"/>
            <dbReference type="Rhea" id="RHEA-COMP:10686"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:18036"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:58307"/>
            <dbReference type="ChEBI" id="CHEBI:58503"/>
            <dbReference type="ChEBI" id="CHEBI:58537"/>
            <dbReference type="EC" id="2.5.1.17"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Cofactor biosynthesis; adenosylcobalamin biosynthesis; adenosylcobalamin from cob(II)yrinate a,c-diamide: step 2/7.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the Cob(I)alamin adenosyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.17" evidence="4"/>
    <dbReference type="EMBL" id="NNBL01000011">
        <property type="protein sequence ID" value="PJN08873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08873">
        <property type="protein sequence ID" value="PJN08873"/>
        <property type="gene ID" value="CG723_25605"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00148">
        <property type="reaction ID" value="UER00233"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008817">
        <property type="term" value="F:cob(I)yrinic acid a,c-diamide adenosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009236">
        <property type="term" value="P:cobalamin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016030">
        <property type="entry name" value="CblAdoTrfase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036451">
        <property type="entry name" value="CblAdoTrfase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029499">
        <property type="entry name" value="PduO-typ"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12213">
        <property type="entry name" value="PTHR12213"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01923">
        <property type="entry name" value="Cob_adeno_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89028">
        <property type="entry name" value="SSF89028"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00636">
        <property type="entry name" value="PduO_Nterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0169">Cobalamin biosynthesis</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Cob_adeno_trans" evidence="5">
        <location>
            <begin position="7"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU366026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PJN08873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="190" mass="20719" checksum="80B6643412DAA0F8" modified="2018-04-25" version="1">MVNLTRIYTRTGDQGTTALGDMSRTAKTDLRISAYADANEANAVIGTAVALGGLDEEVVKVLVRVQNDLFDVGADLSTPVVEDPKYPPLRVEQFYVDKLEADCDRFNEQLEKLRSFILPGGTPGAALLHQACTVVRRAERSTWAALDVHGESMNPLTATYLNRLSDLLFILARTANKAVGDVLWVPGGER</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JPZ1</accession>
    <name>A0A2M9JPZ1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">MarR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_25950</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000011">
        <property type="protein sequence ID" value="PJN08930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08930">
        <property type="protein sequence ID" value="PJN08930"/>
        <property type="gene ID" value="CG723_25950"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000835">
        <property type="entry name" value="HTH_MarR-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023187">
        <property type="entry name" value="Tscrpt_reg_MarR-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12802">
        <property type="entry name" value="MarR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00598">
        <property type="entry name" value="HTHMARR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00347">
        <property type="entry name" value="HTH_MARR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01117">
        <property type="entry name" value="HTH_MARR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50995">
        <property type="entry name" value="HTH_MARR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH marR-type" evidence="2">
        <location>
            <begin position="33"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN08930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="167" mass="18317" checksum="7D94CB6752FC68E5" modified="2018-04-25" version="1">MGADVHEDGNGARPGAEFDATESGVDHEFLSLERELTVFLRRARASSGEMARAVHPDLEPAAYGLLARLEECGRQRATELAAYVGVGKATMSRQLRALEDLGLVAREPDPADGRAWLVHLTDEGRANFRQVRDARRATYVRQLAGWDRTEVAELARLLHQLNAGAEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JQ74</accession>
    <name>A0A2M9JQ74_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_25885</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000011">
        <property type="protein sequence ID" value="PJN09024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN09024">
        <property type="protein sequence ID" value="PJN09024"/>
        <property type="gene ID" value="CG723_25885"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021708">
        <property type="entry name" value="DUF3291"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11695">
        <property type="entry name" value="DUF3291"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF3291" evidence="2">
        <location>
            <begin position="18"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="domain" description="DUF3291" evidence="2">
        <location>
            <begin position="77"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="100"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF11695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN09024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="129" mass="14086" checksum="A502D35818250DE1" modified="2018-04-25" version="1">MTDYGTAHTTENGTRHELAQVNIGRLTAPLDSEQLRDFAEGLDPVNAVADASDGFVWRLKDDTGDATSFRIFDDAWLPTVEEAEERLVHLRTHGPTPYAFNLRTSFPAGDAGPEPEPTSEPESVSRSAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JQA6</accession>
    <name>A0A2M9JQA6_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Mycothiol acetyltransferase</fullName>
            <shortName evidence="2">MSH acetyltransferase</shortName>
            <ecNumber evidence="2">2.3.1.189</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Mycothiol synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2 4" type="primary">mshD</name>
        <name evidence="4" type="ORF">CG723_24325</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CB01635</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>1D-myo-inositol 2-(L-cysteinylamino)-2-deoxy-alpha-D-glucopyranoside + acetyl-CoA = CoA + H(+) + mycothiol</text>
            <dbReference type="Rhea" id="RHEA:26172"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16768"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:58887"/>
            <dbReference type="EC" id="2.3.1.189"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="2">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the acetyltransferase family. MshD subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.189" evidence="2"/>
    <dbReference type="EMBL" id="NNBL01000010">
        <property type="protein sequence ID" value="PJN09059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN09059">
        <property type="protein sequence ID" value="PJN09059"/>
        <property type="gene ID" value="CG723_24325"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035447">
        <property type="term" value="F:mycothiol synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010125">
        <property type="term" value="P:mycothiol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01698">
        <property type="entry name" value="MshD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017813">
        <property type="entry name" value="Mycothiol_AcTrfase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF021524">
        <property type="entry name" value="MSH_acetyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03448">
        <property type="entry name" value="mycothiol_MshD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="3">
        <location>
            <begin position="15"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="domain" description="N-acetyltransferase" evidence="3">
        <location>
            <begin position="165"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="region of interest" description="Acetyl-CoA binding 1" evidence="2">
        <location>
            <begin position="90"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Acetyl-CoA binding 2" evidence="2">
        <location>
            <begin position="246"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="region of interest" description="Acetyl-CoA binding 2" evidence="2">
        <location>
            <begin position="253"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="46"/>
        </location>
        <ligand>
            <name>1D-myo-inositol 2-(L-cysteinylamino)-2-deoxy-alpha-D-glucopyranoside</name>
            <dbReference type="ChEBI" id="CHEBI:58887"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="192"/>
        </location>
        <ligand>
            <name>1D-myo-inositol 2-(L-cysteinylamino)-2-deoxy-alpha-D-glucopyranoside</name>
            <dbReference type="ChEBI" id="CHEBI:58887"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="233"/>
        </location>
        <ligand>
            <name>1D-myo-inositol 2-(L-cysteinylamino)-2-deoxy-alpha-D-glucopyranoside</name>
            <dbReference type="ChEBI" id="CHEBI:58887"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="242"/>
        </location>
        <ligand>
            <name>1D-myo-inositol 2-(L-cysteinylamino)-2-deoxy-alpha-D-glucopyranoside</name>
            <dbReference type="ChEBI" id="CHEBI:58887"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="280"/>
        </location>
        <ligand>
            <name>1D-myo-inositol 2-(L-cysteinylamino)-2-deoxy-alpha-D-glucopyranoside</name>
            <dbReference type="ChEBI" id="CHEBI:58887"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PJN09059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="310" mass="33336" checksum="9BA72CD80FC690D1" modified="2018-04-25" version="1">MTSDAVPTAPDRQIETLTALTPDQAEAVLEILVDAARADGQQAVSEQGRLQLRGGPREGVRHFLLKVDRQLIGYGQLEDTDPIEAPAAELVVHPAHRGHGHGRALGSALLGASGKRLRVWAHGGHSAARHLSQVLGLTLFRELRQMRRPLAEGPPLAEPVLPEGVAIRTFVPGEDDAAWLAVNAAAFAHHPEQGSLTQRDLDDRKAEPWFDPAGFFLAVREGDGEVIGFHWTKVHAEEQLGEVYVVGVAPGNQGGGLGKALTAVGLRHLAASGMPTAMLYVDADNKPAVTVYERLGFVTHETDLMYRTES</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JQB7</accession>
    <name>A0A2M9JQB7_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Sulfurtransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CG723_24390</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CB01635</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>hydrogen cyanide + thiosulfate = 2 H(+) + sulfite + thiocyanate</text>
            <dbReference type="Rhea" id="RHEA:16881"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17359"/>
            <dbReference type="ChEBI" id="CHEBI:18022"/>
            <dbReference type="ChEBI" id="CHEBI:18407"/>
            <dbReference type="ChEBI" id="CHEBI:33542"/>
            <dbReference type="EC" id="2.8.1.1"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000010">
        <property type="protein sequence ID" value="PJN09071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN09071">
        <property type="protein sequence ID" value="PJN09071"/>
        <property type="gene ID" value="CG723_24390"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004792">
        <property type="term" value="F:thiosulfate sulfurtransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001307">
        <property type="entry name" value="Thiosulphate_STrfase_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00581">
        <property type="entry name" value="Rhodanese"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00450">
        <property type="entry name" value="RHOD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52821">
        <property type="entry name" value="SSF52821"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00683">
        <property type="entry name" value="RHODANESE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Rhodanese" evidence="4">
        <location>
            <begin position="18"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodanese" evidence="4">
        <location>
            <begin position="154"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="180"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="185"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU000507"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PJN09071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="279" mass="31336" checksum="CF50597F5F0917AA" modified="2018-04-25" version="1">MSRSDVLVDADWVEANLDNPKVVIVEVDEDASAYDKNHIKNAIKVDWQQDLQDPVRRDFIDQAGFEKLLSARGVANDDTVVLYGGNNNWFASYAYWYFKLYGHDSVKLLDGGRKKWELDSRDLVAEIVQRPATEYKAKAQDTSIRAFRDDVVAAIGSLNLVDVRSPDEFSGKLLAPAHLPQEQSQRPGHVPSARNIPWSKNANDDGTFKSDDELKALYEDEQVDLAKDTIAYCRIGERSALTWFVLHELLGQANVKNYDGSWTEYGSLVGVPIELGANK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JQD2</accession>
    <name>A0A2M9JQD2_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Inhibitor_I42 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_24410</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000010">
        <property type="protein sequence ID" value="PJN09074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN09074">
        <property type="protein sequence ID" value="PJN09074"/>
        <property type="gene ID" value="CG723_24410"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036331">
        <property type="entry name" value="Chagasin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018990">
        <property type="entry name" value="Prot_inh_I42_chagasin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09394">
        <property type="entry name" value="Inhibitor_I42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141066">
        <property type="entry name" value="SSF141066"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014942140" description="Inhibitor_I42 domain-containing protein" evidence="1">
        <location>
            <begin position="22"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="domain" description="Inhibitor_I42" evidence="2">
        <location>
            <begin position="35"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN09074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="152" mass="15536" checksum="E99443DBC7373E49" modified="2018-04-25" version="1">MRTAAASAAALVTLSGCGGSAGPAAIGPGERSVSVDKGDTFTLEVPASPALGQNWYLASPRPDQGVVTYQGRREEEDGGDEDLIGSGDGAQFFDFKARAAGTTTVKLLFCPHGLCGSAAEVSASPVPTATTTEGPTKSDDEVAYYVYTITVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-06-02" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JQH5</accession>
    <name>A0A2M9JQH5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">DNA-binding response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CG723_24690</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000010">
        <property type="protein sequence ID" value="PJN09116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_018527980.1">
        <property type="nucleotide sequence ID" value="NZ_NNBL01000010.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN09116">
        <property type="protein sequence ID" value="PJN09116"/>
        <property type="gene ID" value="CG723_24690"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00383">
        <property type="entry name" value="trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="3"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="domain" description="OmpR/PhoB-type" evidence="5">
        <location>
            <begin position="127"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="3">
        <location>
            <begin position="127"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PJN09116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="226" mass="25128" checksum="DF525B4F7D07800D" modified="2018-04-25" version="1">MTRVLVVEDEESFSDALSYMLRKEGFEVAIAATGPDGLDEFERNGADLVLLDLMLPGLPGTEVCRQLRGRSNVPVIMVTAKDSEIDKVVGLEIGADDYVTKPFSSRELVARIRAVLRRRGEPEEVAPQALEAGPVRMDVDRHVVTVSGSKVDLPLKEFDLLEMLLRNAGRVLTRMQLIDRVWGADYVGDTKTLDVHVKRLRAKIEPDPGAPRYLVTVRGLGYKFEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JR69</accession>
    <name>A0A2M9JR69_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CG723_23710</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000009">
        <property type="protein sequence ID" value="PJN09344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN09344">
        <property type="protein sequence ID" value="PJN09344"/>
        <property type="gene ID" value="CG723_23710"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PJN09344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="123" mass="13621" checksum="54CFE70DE7A4AB93" modified="2018-04-25" version="1">MALKEGQRVELAADTRLTDSVEVSGVIIGFLSLAAGTSGIIERVTDHQDESEDVREHERLKSLLDAFGLDMPTESRRQLEEKVASLEPAWTAFQERVPHVSVRVRFDNGFILDGADEAVFVPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JRC6</accession>
    <name>A0A2M9JRC6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CG723_23615</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CB01635</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000009">
        <property type="protein sequence ID" value="PJN09429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN09429">
        <property type="protein sequence ID" value="PJN09429"/>
        <property type="gene ID" value="CG723_23615"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="41"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="98"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="130"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="157"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="197"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="252"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="87"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PJN09429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="287" mass="30480" checksum="D7E5EEEAF46ACCCB" modified="2018-04-25" version="1">MESPVATTAEATSRLKPAKGTVPQAARGTRRRLGPGRSVPFGRLIGPALLIAVWWAASAVGYLDPRILSGPGTVLSTAADLVSTGRLQDNVLVSLQRAGLGLFFGVAAGVILAVAAGLNRTGEYLLDGTLQVKRAIPSLAMLPLLILWLGIGEQMKVTVIALGVAVNMYINTYASLTGIDSRYVELAEGLDLSRWQFIRKVVVPGSLPGFFVGLRLGVTASWLGLIVVEQINATQGIGYMMFQAQQYAQSDVIIVGLVAYGIFGFASDAAVRAIERRVLSWRRTLAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JRD2</accession>
    <name>A0A2M9JRD2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CG723_21925</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000008">
        <property type="protein sequence ID" value="PJN09441.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN09441">
        <property type="protein sequence ID" value="PJN09441"/>
        <property type="gene ID" value="CG723_21925"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PJN09441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="110" mass="11820" checksum="55BCB497B50DE139" modified="2018-04-25" version="1">MPSFKIDLQTAIVFVATAPEPKLINKKTGERAMDRDNPNVALSTVGLLVSDEGEGNLYQVTVPETGLPEGLAPGMPVKVTGLKARDWENEFNGQKRHGISFRAIALTSGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JRF3</accession>
    <name>A0A2M9JRF3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_21970</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000008">
        <property type="protein sequence ID" value="PJN09449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN09449">
        <property type="protein sequence ID" value="PJN09449"/>
        <property type="gene ID" value="CG723_21970"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041657">
        <property type="entry name" value="HTH_17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010093">
        <property type="entry name" value="SinI_DNA-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12728">
        <property type="entry name" value="HTH_17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01764">
        <property type="entry name" value="excise"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH_17" evidence="1">
        <location>
            <begin position="12"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN09449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="68" mass="7778" checksum="3095B395F93D9937" modified="2018-04-25" version="1">MTTALIQRKWHTTAEVAEMLGYGLSKTKMLVLTGEIRSIKDGRNRRILPRYVDEYIERLALQAEGDVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JRR6</accession>
    <name>A0A2M9JRR6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">TetR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_22745</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000008">
        <property type="protein sequence ID" value="PJN09559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN09559">
        <property type="protein sequence ID" value="PJN09559"/>
        <property type="gene ID" value="CG723_22745"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004111">
        <property type="entry name" value="Repressor_TetR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02909">
        <property type="entry name" value="TetR_C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="17"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="40"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN09559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="232" mass="25147" checksum="498694F0D3A9F45F" modified="2018-04-25" version="1">MPVWERPEPQPRAAPVPLSREKIAATAIRLADTHGLDGLSVRKIAKELGVGPMRLYDYVINRSELLDLMVDVVYARIAEVGQHSAWRATVLAIAHATRDAALDHEWFSDLLGGRPHLGPHALAVGEATAAALSQAPGVRGIDDLQRTLGALNAFIIGAVRREVTERRTARSTGTDEAAFQASLGPYLTRMLNTGRYPTIARLVIDGAHLNAAETFNHNLTTVLDGITSRPRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JS86</accession>
    <name>A0A2M9JS86_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Ammonium transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CG723_21200</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CB01635</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the ammonia transporter channel (TC 1.A.11.2) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000007">
        <property type="protein sequence ID" value="PJN09722.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN09722">
        <property type="protein sequence ID" value="PJN09722"/>
        <property type="gene ID" value="CG723_21200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008519">
        <property type="term" value="F:ammonium transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3430.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029020">
        <property type="entry name" value="Ammonium/urea_transptr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001905">
        <property type="entry name" value="Ammonium_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018047">
        <property type="entry name" value="Ammonium_transpt_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024041">
        <property type="entry name" value="NH4_transpt_AmtB-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43029">
        <property type="entry name" value="PTHR43029"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00909">
        <property type="entry name" value="Ammonium_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00836">
        <property type="entry name" value="amt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01219">
        <property type="entry name" value="AMMONIUM_TRANSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0924">Ammonia transport</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="52"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="107"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="139"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="180"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="211"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="240"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="269"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="296"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="327"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="366"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="domain" description="Ammonium_transp" evidence="10">
        <location>
            <begin position="21"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="425"/>
            <end position="453"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU362002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PJN09722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="453" mass="46744" checksum="EAD8B912CA2E644F" modified="2018-04-25" version="1">MPPGITLAADTPTLSAANTGFMLICSALVMIMTPGLAFFYGGMVRVKSTLNMLMMSFISLGIVTILWVLYGFSAAFGTDHGSLIGWSSDYVGLSGIGLTQLWDGYTIPVYVFAVFQLMFAIITPALISGALADRVKFSAWALFITLWATLVYFPVAHWVWGTGGWAFDLGVIDFAGGTAVHINAGAAALGVILVIGKRVGFKKDPMRPHSLPLVMLGAGLLWFGWFGFNAGSWLGNDDGVGALMFVNTQVATAAAMLAWLIYEKIRHGACTTLGAASGAVAGLVAITPSGGSCSPLGAIAIGVIAGVLCAMAVGLKYRFGYDDSLDVVGVHLVGGVIGSLLIGFFATGGGQSDAQGLFYGGGLTQLWKQLAGVGAVLAYSLVVSAILAFLIDKAIGMRVSEDDEVSGIDQVEHAETAYDFSGAGGGTVLRSAAPGPGPGPVDESAAQTKKVDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-09-29" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JSA7</accession>
    <name>A0A2M9JSA7_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 5">Signal peptidase I</fullName>
            <ecNumber evidence="3 5">3.4.21.89</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">lepB</name>
        <name evidence="8" type="ORF">CG723_21310</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CB01635</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 5">
            <text>Cleavage of hydrophobic, N-terminal signal or leader sequences from secreted and periplasmic proteins.</text>
            <dbReference type="EC" id="3.4.21.89"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Membrane</location>
            <topology evidence="5">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the peptidase S26 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.89" evidence="3 5"/>
    <dbReference type="EMBL" id="NNBL01000007">
        <property type="protein sequence ID" value="PJN09743.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN09743">
        <property type="protein sequence ID" value="PJN09743"/>
        <property type="gene ID" value="CG723_21310"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006465">
        <property type="term" value="P:signal peptide processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06530">
        <property type="entry name" value="S26_SPase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036286">
        <property type="entry name" value="LexA/Signal_pep-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000223">
        <property type="entry name" value="Pept_S26A_signal_pept_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019758">
        <property type="entry name" value="Pept_S26A_signal_pept_1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019533">
        <property type="entry name" value="Peptidase_S26"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43390">
        <property type="entry name" value="PTHR43390"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10502">
        <property type="entry name" value="Peptidase_S26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00727">
        <property type="entry name" value="LEADERPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51306">
        <property type="entry name" value="SSF51306"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02227">
        <property type="entry name" value="sigpep_I_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00761">
        <property type="entry name" value="SPASE_I_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="55"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_S26" evidence="7">
        <location>
            <begin position="54"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="active site" evidence="4">
        <location>
            <position position="83"/>
        </location>
    </feature>
    <feature type="active site" evidence="4">
        <location>
            <position position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR600223-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF10502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PJN09743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="378" mass="42234" checksum="3E4D97FC5839B38B" modified="2018-04-25" version="1">MGNRGRSHSRRGGGDTRLPTGTRRAGTPPLPGRAERRRLARKVKRRRQRSALKEIPLLIGVALLIALVLKTFLVQAFVIPSGSMEQTIRIGDRVLVDKLTPWFGAKPHRGDVVVFKDPGKWLEQEQGAKKDAPVGVKQVKEGLTWIGLLPSDDERDLIKRVIAVGGDTVKCCDKQGRVTVNGTPLNEPYIHPGDVPSKFEFEVKVPKGRLFVMGDHRSNSADSRFHRTEPFSGTVSEKSVVGRARVIAWPVGHWTTLPEPDTYATVAAAQNRSAAARQPSHRVASEDLNGLIPLPSPAELPLVMGVVGLHRVWDDRQRHGVRSGCGGLGGRRTVRARARRAARAIRRRSGIGRDGRREPRQWRRERRRARWWTGRRPW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JSP1</accession>
    <name>A0A2M9JSP1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Heme ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CG723_19330</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000006">
        <property type="protein sequence ID" value="PJN09896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN09896">
        <property type="protein sequence ID" value="PJN09896"/>
        <property type="gene ID" value="CG723_19330"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="9"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="258"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="41"/>
            <end position="48"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PJN09896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="522" mass="56051" checksum="25A545A2DFD050BC" modified="2018-04-25" version="1">MNASSPPAVELRGITKRFPGVVANRDIDITVRRGTVHALCGENGAGKSTLMKILYGMQKPDEGTIAVDGTQVAFATPADAIARGIGMVHQHFMLADNLTVLENVVLGAEKLHGIGGKARTKIREISEAYGLGVRPDVLVEELGVADRQRVEILKVLYRGARTLILDEPTAVLVPQEVDALFDNLRELKSEGLTVIFISHKLGEVLSVADEITVIRRGTTVGTADPKSTSTKQLAELMVGSELPSPETEESTVTDTPMLHLGGVRLTQTDLDGVERVILDDVSFTIHRGEVLGIAGVEGNGQSELVEAIMGMRAPDRGTVALDGADVTRTPTRKRREAGVGYIPEDRHRHGLLLEAPLWENRVLGHVTERPNSKGGLLDLKAARADTERIVRDYDVRTPGIEVTAASLSGGNQQKLIVGREMSHAPKLLIAAHPTRGVDVGAQAQIWDQIRRARREGLAVLLISADLDELIGLSDTLRVMYRGRLVADADPATITPEELGSAMTGAASGHLEHTEDAEGGDAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JSY6</accession>
    <name>A0A2M9JSY6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_19930</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000006">
        <property type="protein sequence ID" value="PJN09995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN09995">
        <property type="protein sequence ID" value="PJN09995"/>
        <property type="gene ID" value="CG723_19930"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="45"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN09995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="263" mass="27372" checksum="F18CE5FD71A37E7D" modified="2018-04-25" version="1">MDGASVRADAWPRAAEDEGGNVKSGVRRAVAAAAVVAALGVTTACGGSSETTDDAKKPAASEKTTAPAKPAEEGAKALTAAELEKAVVATGDVKGYKVEKVGKDDLPPTESVAAKPASCQPLADMFMFSTQPTAKDRVVRTLMATDELDPKVTSLALLAHDGADAAKVMKDLRTASKSCTAYEHVDYKYSGVKERPAPDAGDEAVSYDVKGVIDGDKVPMTFTVVRSGSTVVAFYTMNMLDSSKTDVPQVIVDAQLAKLEKTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JT01</accession>
    <name>A0A2M9JT01_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">UDP-N-acetyl-D-glucosamine dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CG723_19985</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CB01635</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the UDP-glucose/GDP-mannose dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000006">
        <property type="protein sequence ID" value="PJN10004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN10004">
        <property type="protein sequence ID" value="PJN10004"/>
        <property type="gene ID" value="CG723_19985"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016628">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000271">
        <property type="term" value="P:polysaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029752">
        <property type="entry name" value="D-isomer_DH_CS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017476">
        <property type="entry name" value="UDP-Glc/GDP-Man"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014027">
        <property type="entry name" value="UDP-Glc/GDP-Man_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036220">
        <property type="entry name" value="UDP-Glc/GDP-Man_DH_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014026">
        <property type="entry name" value="UDP-Glc/GDP-Man_DH_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001732">
        <property type="entry name" value="UDP-Glc/GDP-Man_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028359">
        <property type="entry name" value="UDP_ManNAc/GlcNAc_DH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00984">
        <property type="entry name" value="UDPG_MGDP_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03720">
        <property type="entry name" value="UDPG_MGDP_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03721">
        <property type="entry name" value="UDPG_MGDP_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF500136">
        <property type="entry name" value="UDP_ManNAc_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000124">
        <property type="entry name" value="UDPglc_GDPman_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00984">
        <property type="entry name" value="UDPG_MGDP_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="SSF48179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52413">
        <property type="entry name" value="SSF52413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03026">
        <property type="entry name" value="NDP-sugDHase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00065">
        <property type="entry name" value="D_2_HYDROXYACID_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0520">NAD</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UDPG_MGDP_dh_C" evidence="4">
        <location>
            <begin position="316"/>
            <end position="411"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR000124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PJN10004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="417" mass="44218" checksum="EBE64151CFC89560" modified="2018-04-25" version="1">MPADLAVIGLGHLGLPLAQAAVATGIATIGYDPARATDLAAGRLPGDGAEGTLTAADIRRMLSGGFRPTGDPVELGRVRTAVICAPAPLGADRSLDLAQLTDATRALAARLRPHTTVIIETPVAPGTTEGVLRPLLEDGSGLRAGRDFHLAYSPGRLDPGSRTHAYATTPKVIGGLTPACTESAAAFYGRLSDKVVRARGPREAETVQLLETNYRHVNIALVNEMAVLCHDLGVDLWDVIRCAETKPFGFQAFRPGPGVGGHGVPQDLSRPPLPVRPLRMVELAQQVNHHMPQYVIQRAATLLNEHGKSARGARVLLLGVTYKPDVADLEGTPAHEIATRLMQLGAAVSYHDPHIPSWNVLGHPVPRADSLYEAAADADLTILLQQHRTYDLQGLSVKAQLLLDTRGATPTGAAHRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JT09</accession>
    <name>A0A2M9JT09_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">MOSC domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_20020</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000006">
        <property type="protein sequence ID" value="PJN10010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN10010">
        <property type="protein sequence ID" value="PJN10010"/>
        <property type="gene ID" value="CG723_20020"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030151">
        <property type="term" value="F:molybdenum ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005302">
        <property type="entry name" value="MoCF_Sase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011037">
        <property type="entry name" value="Pyrv_Knase-like_insert_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03473">
        <property type="entry name" value="MOSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50800">
        <property type="entry name" value="SSF50800"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51340">
        <property type="entry name" value="MOSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MOSC" evidence="2">
        <location>
            <begin position="29"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN10010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="232" mass="24689" checksum="8F462B25236AEF24" modified="2018-04-25" version="1">MKLLSLNVGRPEASEHTDQAEGVTGIDKQAVPGPVRVAAPGPKGVGASGLEGDAVCDMRHHGGDHQAVYAFAREDLDEWQGTLGRDLRNGSFGENLTTEGVDVTGAKIGERWRVGSDLVLEVASGRIPCRTFQGHLGEKGWVKRFTARAAPGAYLRVIEPGAIRAGDTIEIVHRPDHEVTVAFQFRAVTTERELLPRLLVAADVLDPEAVETARMYVAKYGDGGAGGDATQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JT43</accession>
    <name>A0A2M9JT43_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 8 11">50S ribosomal protein L22</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">rplV</name>
        <name evidence="12" type="ORF">CG723_20305</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">CB01635</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome.</text>
    </comment>
    <comment type="function">
        <text evidence="7">This protein binds specifically to 23S rRNA; its binding is stimulated by other ribosomal proteins, e.g. L4, L17, and L20. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.</text>
    </comment>
    <comment type="function">
        <text evidence="8 11">This protein binds specifically to 23S rRNA; its binding is stimulated by other ribosomal proteins, e.g., L4, L17, and L20. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8 10">Part of the 50S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 8 9">Belongs to the universal ribosomal protein uL22 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000006">
        <property type="protein sequence ID" value="PJN10061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_026249422.1">
        <property type="nucleotide sequence ID" value="NZ_NNBL01000006.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN10061">
        <property type="protein sequence ID" value="PJN10061"/>
        <property type="gene ID" value="CG723_20305"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015934">
        <property type="term" value="C:large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00336">
        <property type="entry name" value="Ribosomal_L22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01331_B">
        <property type="entry name" value="Ribosomal_L22_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001063">
        <property type="entry name" value="Ribosomal_L22"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018260">
        <property type="entry name" value="Ribosomal_L22/L17_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036394">
        <property type="entry name" value="Ribosomal_L22/L17_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005727">
        <property type="entry name" value="Ribosomal_L22_bac/chlpt-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13501">
        <property type="entry name" value="PTHR13501"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00237">
        <property type="entry name" value="Ribosomal_L22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54843">
        <property type="entry name" value="SSF54843"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01044">
        <property type="entry name" value="rplV_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00464">
        <property type="entry name" value="RIBOSOMAL_L22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 8 9" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5 8 9" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="4 8 10" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 8 10" id="KW-0699">rRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00021205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PJN10061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="115" mass="12747" checksum="85FCC4F40A3DB649" modified="2018-04-25" version="1">MEARAQARYIRVTPMKARRVVDLIRGMDATEAQAVLRFAPQAASVPVGKVLDSAIANAAHNYDHTDANSLVISEAYVDEGPTLKRFRPRAQGRAYRIRKRTSHITVVVSSKEGTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JT68</accession>
    <name>A0A2M9JT68_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF397 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_20360</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000006">
        <property type="protein sequence ID" value="PJN10070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN10070">
        <property type="protein sequence ID" value="PJN10070"/>
        <property type="gene ID" value="CG723_20360"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007278">
        <property type="entry name" value="DUF397"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04149">
        <property type="entry name" value="DUF397"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF397" evidence="1">
        <location>
            <begin position="14"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN10070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="69" mass="7145" checksum="A1B35309439BEF35" modified="2018-04-25" version="1">MTGKSSAWAASDLTWFKSSYSSSGDGNDCVEVAATPGTVHVRDSKNAQAACFSVTAEAWADFVTYASGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JTH3</accession>
    <name>A0A2M9JTH3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Dihydrofolate reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_17350</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000005">
        <property type="protein sequence ID" value="PJN10174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN10174">
        <property type="protein sequence ID" value="PJN10174"/>
        <property type="gene ID" value="CG723_17350"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008703">
        <property type="term" value="F:5-amino-6-(5-phosphoribosylamino)uracil reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009231">
        <property type="term" value="P:riboflavin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.430.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024072">
        <property type="entry name" value="DHFR-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002734">
        <property type="entry name" value="RibDG_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01872">
        <property type="entry name" value="RibD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53597">
        <property type="entry name" value="SSF53597"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RibD_C" evidence="1">
        <location>
            <begin position="4"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN10174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="187" mass="20695" checksum="5C3E0DB62A392158" modified="2018-04-25" version="1">MRTLAITQNITVDGCVEMLTDWFEPQAQGNADMADVLAEGHRQDSEADALLVGRRTFEDFRGYWPGLTDDTTGISDYLNQVRKYVVSGSIEDPQWENSIVLSGDAVKEVTALKALEGGKDIVLTGSISLAHTLIEAGLVDEYRLFVYPVVQGRGRRLFPGGYEVPRLRLVDSKSFRSGIVLLRYVPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JTN5</accession>
    <name>A0A2M9JTN5_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">GMP synthase [glutamine-hydrolyzing]</fullName>
            <ecNumber evidence="9">6.3.5.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">GMP synthetase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Glutamine amidotransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">guaA</name>
        <name evidence="12" type="ORF">CG723_19920</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">CB01635</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 9">Catalyzes the synthesis of GMP from XMP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>ATP + H2O + L-glutamine + XMP = AMP + diphosphate + GMP + 2 H(+) + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:11680"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57464"/>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.3.5.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 9">Purine metabolism; GMP biosynthesis; GMP from XMP (L-Gln route): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Homodimer.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.2" evidence="9"/>
    <dbReference type="EMBL" id="NNBL01000006">
        <property type="protein sequence ID" value="PJN10147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN10147">
        <property type="protein sequence ID" value="PJN10147"/>
        <property type="gene ID" value="CG723_19920"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00189">
        <property type="reaction ID" value="UER00296"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003922">
        <property type="term" value="F:GMP synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016462">
        <property type="term" value="F:pyrophosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01742">
        <property type="entry name" value="GATase1_GMP_Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01997">
        <property type="entry name" value="GMP_synthase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00344">
        <property type="entry name" value="GMP_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017926">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001674">
        <property type="entry name" value="GMP_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004739">
        <property type="entry name" value="GMP_synth_GATase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022955">
        <property type="entry name" value="GMP_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025777">
        <property type="entry name" value="GMPS_ATP_PPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022310">
        <property type="entry name" value="NAD/GMP_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00117">
        <property type="entry name" value="GATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00958">
        <property type="entry name" value="GMP_synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02540">
        <property type="entry name" value="NAD_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00884">
        <property type="entry name" value="guaA_Cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00888">
        <property type="entry name" value="guaA_Nterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51553">
        <property type="entry name" value="GMPS_ATP_PPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 9" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="5 9 10" id="KW-0332">GMP biosynthesis</keyword>
    <keyword evidence="3 9" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 9 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 9 10" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GMPS ATP-PPase" evidence="11">
        <location>
            <begin position="204"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="9">
        <location>
            <position position="89"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="177"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="179"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="231"/>
            <end position="237"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PJN10147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="528" mass="56592" checksum="27ABB4D175249FD6" modified="2018-04-25" version="1">MPSASPAAAPDTVLVVDFGAQYAQLIARRVREARVYSEIVPSTMPVEEMLAKNPKAIILSGGPSSVYAEGAPRLDRAIFEAGVPVFGMCYGFQLMATTLGGTVDDNGAREYGRTPLTVSRPGSTLFEGTPAEQSVWMSHGDACSAAPEGFTVTASTDVVPVAAFENDAKKLYGVQYHPEVMHSTYGQQVLEHFLYRGAGIEPTWTTGNVIEEQVAAIREQVGTKRAICGLSGGVDSAVAAALVQKAIGSQLTCVYVDHGLMRKGETEQVEKDFVAATGANLKVVDASQRFLDALAGVSDPETKRKIIGREFIRVFEQAQAEIVAEGAADGEDVAFLVQGTLYPDVVESGGGTGTANIKSHHNVGGLPEDLEFALVEPLRQLFKDEVRMVGAELGLPDEIVQRQPFPGPGLGIRIVGEVTKDRLDLLREADAIAREELTAAGLDRDIWQCPVVLLADVRSVGVQGDGRTYGHPIVLRPVSSEDAMTADWTRMPYDVLAKISTRITNEVADVNRVVLDVTSKPPGTIEWE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JV71</accession>
    <name>A0A2M9JV71_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Sugar kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_16510</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ROK (NagC/XylR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000004">
        <property type="protein sequence ID" value="PJN10781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN10781">
        <property type="protein sequence ID" value="PJN10781"/>
        <property type="gene ID" value="CG723_16510"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000835">
        <property type="entry name" value="HTH_MarR-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000600">
        <property type="entry name" value="ROK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18964">
        <property type="entry name" value="PTHR18964"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12802">
        <property type="entry name" value="MarR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00480">
        <property type="entry name" value="ROK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="HTH marR-type" evidence="2">
        <location>
            <begin position="20"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN10781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="392" mass="39795" checksum="ACE52B81618E2DC3" modified="2018-04-25" version="1">MAGTAPGTPGTPSVLRAMNDRAALDLLVAHGPLTRTRIGELTGLSKPTTSQLLSRLEAVGLVRTTGSQTGRPGPNAVLYEIHPGAAHIAAVSADPTGITAVVADIAGAERGRCRIEAVAVADDVRNRTAQLVAEAFDGALRLAGLGHGDITATVIGTPGAIDPHTGQLRYAPHLPGWHSRTLLAELAEVLGTPVSIENDVNLAAIAEQYEGAAQDHDDFVLAYVDEGVGAAIVLGGVLLRGATGGAGEIGYMPLPGAPLARGGDEEIAGEDAGGGFQSLVAAPAVRLLAGGAKDLGEALADPAVLDEVARRLATGLAAVVAVVDPELVVLSGQVAQAGGEALRVRVEDELTGLALPRPQLRISDLDDDPILTGALRSALTQARDIVFDTGNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JV91</accession>
    <name>A0A2M9JV91_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">FAD-dependent oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_16575</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000004">
        <property type="protein sequence ID" value="PJN10793.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN10793">
        <property type="protein sequence ID" value="PJN10793"/>
        <property type="gene ID" value="CG723_16575"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD_binding_3" evidence="1">
        <location>
            <begin position="8"/>
            <end position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN10793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="485" mass="51759" checksum="CA8E375A25DA0C53" modified="2018-04-25" version="1">MNGTTPRTVIVVGSGPTGLLLAGDLAAAGVPVTVVEKRPHKISNLSRAFVLHARTLEQLDARGLADGIEAKGQALDRLQLFGRLAVDLTVLPSRFRHLLVLPQYEVEAALQQRATDAGVKFAYETEVTGLAQDADGVTLQVRTADGESTALRAAYVVGADGMRSAVRESVGLPFPGKSVIRSVVLADVKLAEEPENVLTANAVGDAFAFIAPFGDGYYRIIGWNRARNVPESAPLGLDEIKEVTRLALGRDYGMHEARWMSRFHSDERQAPAYRVGRVLLAGDAAHVHTPAGGQGMNTGLQDAANLGWKLAAVVNGRAGDALLDTYEAERHPVGKAVLRSSGGIVRLAMANRPWTLAARAALTAFLARVRPARTRLLGQLTGIGVAYPAPRGAHRLVGTRVPDVALKEGRLYEALRQGLFVLIVPEGAHDKGDRYTVTHWASDRRTALLVRPDGYVAWASDGEPADGGAISAGMPDSIDSYSFRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JVN4</accession>
    <name>A0A2M9JVN4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Class E sortase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CG723_15635</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000004">
        <property type="protein sequence ID" value="PJN10924.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN10924">
        <property type="protein sequence ID" value="PJN10924"/>
        <property type="gene ID" value="CG723_15635"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05830">
        <property type="entry name" value="Sortase_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005754">
        <property type="entry name" value="Sortase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023365">
        <property type="entry name" value="Sortase_dom-sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042003">
        <property type="entry name" value="Sortase_E"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04203">
        <property type="entry name" value="Sortase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63817">
        <property type="entry name" value="SSF63817"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01076">
        <property type="entry name" value="sortase_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="63"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="72"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PJN10924.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="264" mass="28395" checksum="1A36BB829C407241" modified="2018-04-25" version="1">MRPPQGRRPSTLRRTLWTGAEVAVTLGVVLLLLVVHQLWWTNREARAGAERKVQALEREWAAAPADGQGDGGQESASDQAGDDTPGGSSGEGSGGGSGGRTSADSTSASRETPRWDQAYAVLTIPRLGLTVPVAEGVGKQNVLNKGYVGHYPATAQPGRAGNFALAGHRNTHGEPFRYINRLRKGDEVRVRTRSAEYTYVVDKTLAQTSARDGGVIAGVPRSEVVRGAGYSEPGYYITLTTCTPEYTSKYRLAVWGKLRSMRPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JVQ8</accession>
    <name>A0A2M9JVQ8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Metal-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CG723_16835</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000004">
        <property type="protein sequence ID" value="PJN10837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN10837">
        <property type="protein sequence ID" value="PJN10837"/>
        <property type="gene ID" value="CG723_16835"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.40.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007899">
        <property type="entry name" value="CHAD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038186">
        <property type="entry name" value="CHAD_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033469">
        <property type="entry name" value="CYTH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023577">
        <property type="entry name" value="CYTH_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05235">
        <property type="entry name" value="CHAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01928">
        <property type="entry name" value="CYTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00880">
        <property type="entry name" value="CHAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01118">
        <property type="entry name" value="CYTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55154">
        <property type="entry name" value="SSF55154"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51708">
        <property type="entry name" value="CHAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51707">
        <property type="entry name" value="CYTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CYTH" evidence="2">
        <location>
            <begin position="5"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="domain" description="CHAD" evidence="3">
        <location>
            <begin position="216"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="186"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PJN10837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="498" mass="53865" checksum="FD301F7CC64414CD" modified="2018-04-25" version="1">MAETKREIERKYEAPVADEGFGLPDLSRVAGVFAVIDKGVVDLDAVYYDTADQRLAAAAITLRRRTGGADAGWHLKLPVSLAEGVRDEIRAPLSDDVPRDLTGLVRSRVREADLVPLMRLRSSRDVHDLTGADGALLAEVSVDGVRAERLTGGAGATSWTEIEVELADGGDPAFLGKVEKKLRKAGASRSASSSKLARALTETGIGPRPPRPADDPETPADHVLAYLRAQRDAIVDLDPAVRRDLPDSVHQMRVATRRLRSALRSYGKILDRAVTDPIGDELKWLAGELGLDRDQEVLTERLSAALDELPRELSTGPVRSRLRTWSRARGSGSRRHLIAVLDGKRYLALLAVLDALVDAPPLRAKQSKNALAKAVKKDFKRLAGRVDEALAEDPGPARDHALHDARKAAKRTRYAAEVAAPALGDRAKDVGKHAKAIQSLLGEHQDSVMAREALRDLAAQAHAAGESSFTYGLLYGREEALAERAEAELPPLWAKAVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JVV9</accession>
    <name>A0A2M9JVV9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_08295</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN10994.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN10994">
        <property type="protein sequence ID" value="PJN10994"/>
        <property type="gene ID" value="CG723_08295"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="49"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN10994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="310" mass="33265" checksum="5F02CBE3E351B5C6" modified="2018-04-25" version="1">MTDPATAASVPDNPVRDLPLHDLAGFTHRWVDAGGVRLHAVEGGQPNGPAVVLLAGFPQTWRAWRKVMPGLADRFHVIAIDLPGQGHSERPDGSYDTHTIAAYVHAAVNALGVSTYWLAAHDIGAWVAFSLALKYQSQLRGVALLDAGIPGITLPGSIPTDPEVAWKTWHFAFHLVPDLPETLLTGREREYVDWFLKVKSLSPDTFDDAEIEQYAAAITADGGLRASLAYYRDAAESARKNHEALEQQHLTVPVLGISSSHGSIPDMAASIRPWADNATGVVVPDAGHFIPDEQPDAVTAALSGFIAQGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-05-25" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JW02</accession>
    <name>A0A2M9JW02_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Cation transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CG723_16080</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CB01635</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000004">
        <property type="protein sequence ID" value="PJN10937.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN10937">
        <property type="protein sequence ID" value="PJN10937"/>
        <property type="gene ID" value="CG723_16080"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008324">
        <property type="term" value="F:cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006829">
        <property type="term" value="P:zinc ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1510.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002524">
        <property type="entry name" value="Cation_efflux"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036837">
        <property type="entry name" value="Cation_efflux_CTD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027469">
        <property type="entry name" value="Cation_efflux_TMD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040177">
        <property type="entry name" value="SLC30A9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13414">
        <property type="entry name" value="PTHR13414"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01545">
        <property type="entry name" value="Cation_efflux"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160240">
        <property type="entry name" value="SSF160240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161111">
        <property type="entry name" value="SSF161111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01297">
        <property type="entry name" value="CDF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="93"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="125"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="185"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="210"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PJN10937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="332" mass="34759" checksum="F7789179238D09E6" modified="2018-04-25" version="1">MGTSAEQSGTAGDTGENGGGESVVTVLVAAAANLGIALAKAVAGVISGSSAMLSEAAHSVADTVTEVLLLTALKRSEKPADEEHPLGYGPERYIWAMLAAVATFVGGAVFSIYDGIHTLIAGEELGNPLISYIVLALAFLLEGFSLRTGIKQARGEAERMGAPVGRYLQRTPDTAVKAVVMEDSAALVGLVLAAGGLLGGQLTGSGVWDAIASLCIGALLLYVAWVLGRSNAELLIGRPLPKPVRLEIREILAGVEHIEAVLELTTLVQGPREALVAAKVDLRDTSTAAQIEWACEEAARRLRERFPNVTRVYLDPTPGFAQRREEGLNPWG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JW17</accession>
    <name>A0A2M9JW17_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_08720</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN11054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN11054">
        <property type="protein sequence ID" value="PJN11054"/>
        <property type="gene ID" value="CG723_08720"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008160">
        <property type="entry name" value="Collagen"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01391">
        <property type="entry name" value="Collagen"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014780112" evidence="2">
        <location>
            <begin position="27"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="49"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="127"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="57"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="84"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN11054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="149" mass="15896" checksum="CCA97877859A1801" modified="2018-04-25" version="1">MKEAWRSPRRRLAIGAALTVMLVAQAVVIVAHQQQIDELQARRIALQGNSVQQGLPGPPGPSGPSGEPGPTGPTGVPGWHGRDGHHGPPGRDGRRGRHGRNGVVIYLRPCRHAAACARCSSELSPVIRRPNHQPPRSVRGPRAAGVCRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JW27</accession>
    <name>A0A2M9JW27_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">1-phosphofructokinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">pfkB</name>
        <name evidence="4" type="ORF">CG723_08965</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CB01635</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the carbohydrate kinase PfkB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN11091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN11091">
        <property type="protein sequence ID" value="PJN11091"/>
        <property type="gene ID" value="CG723_08965"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008662">
        <property type="term" value="F:1-phosphofructokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01164">
        <property type="entry name" value="FruK_PfkB_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022463">
        <property type="entry name" value="1-PFruKinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011611">
        <property type="entry name" value="PfkB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017583">
        <property type="entry name" value="Tagatose/fructose_Pkinase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00294">
        <property type="entry name" value="PfkB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000535">
        <property type="entry name" value="1PFK/6PFK/LacC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="SSF53613"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03168">
        <property type="entry name" value="1-PFK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03828">
        <property type="entry name" value="pfkB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PfkB" evidence="3">
        <location>
            <begin position="20"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRNR" id="PIRNR000535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PJN11091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="315" mass="31517" checksum="4B2AE7440DDADB5A" modified="2018-04-25" version="1">MILTVTPNPSLDRTYEVPALDRGEVLRATDERMDPGGKGVNVSRAVAAAGAPTLAVLPLGGAPGALVAELLDAQGISVDPVPVAGQTRSNIALAEPDGTLTKINASGPELTPEEAESLLTVVGERSAGADWIACCGSLPRGLAPSWYAELVARAHAAGARIALDTSGPALLAALRERPDVVKPNGEELAEAVGRPLATVGDALKAAEELRDLGARAVLASLGSDGQLLVDGTGAWFATAPVDTVRSNVGAGDSSLAGFLIAGGTGPRALASAVAHGAAAVQLPGSAMPTPADLDPDAVTLTSDVPLDRALKEPAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JWL1</accession>
    <name>A0A2M9JWL1_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Putative fluoride ion transporter CrcB</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">crcB</name>
        <name evidence="10" type="ORF">CG723_10170</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CB01635</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 9">Important for reducing fluoride concentration in the cell, thus reducing its toxicity.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cell membrane</location>
            <topology evidence="9">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the CrcB (TC 9.B.71) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN11290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN11290">
        <property type="protein sequence ID" value="PJN11290"/>
        <property type="gene ID" value="CG723_10170"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903425">
        <property type="term" value="F:fluoride transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00454">
        <property type="entry name" value="CrcB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003691">
        <property type="entry name" value="CrcB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28259">
        <property type="entry name" value="PTHR28259"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02537">
        <property type="entry name" value="CRCB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00494">
        <property type="entry name" value="crcB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="32"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="63"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="101"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007610"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PJN11290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="126" mass="12876" checksum="F53EE0917AB56991" modified="2018-04-25" version="1">MNWLLVIVGAMVGAPLRYLTDRAVQTRHDSVFPWGTFTVNACGCLVLGLLTGAVAAGAASSRVQLLIGTGLCGALTTYSTFSYETLRLGEDGARLFAVANVVASVAVGLGAAFAGVALADALWGQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JWT0</accession>
    <name>A0A2M9JWT0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cobalt transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_10505</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN11351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN11351">
        <property type="protein sequence ID" value="PJN11351"/>
        <property type="gene ID" value="CG723_10505"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012667">
        <property type="entry name" value="CbtB_put"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09489">
        <property type="entry name" value="CbtB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="24"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN11351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="73" mass="7735" checksum="E9ADA2C72D96AE52" modified="2018-04-25" version="1">MAQTVAQPTATTPVLPAALPLKAIAPWAVFFGILMLVLLYFVGAEQGATAVVSGEGVHEWVHDARHLLGFPCH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JX36</accession>
    <name>A0A2M9JX36_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">4Fe-4S ferredoxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CG723_11045</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN11439.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055563275.1">
        <property type="nucleotide sequence ID" value="NZ_NNBL01000003.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN11439">
        <property type="protein sequence ID" value="PJN11439"/>
        <property type="gene ID" value="CG723_11045"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12838">
        <property type="entry name" value="Fer4_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="4">
        <location>
            <begin position="10"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="4">
        <location>
            <begin position="42"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PJN11439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="75" mass="8251" checksum="7B0C6A9B1D6ADFDC" modified="2018-04-25" version="1">MPVVPQRADVPVTIDESRCIDGCTLCVDMCPLDSLAIREDNGKAYMHVDECWYCGPCAARCPTGAVTVNMPYLLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JXL2</accession>
    <name>A0A2M9JXL2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Esterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CG723_11930</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN11592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN11592">
        <property type="protein sequence ID" value="PJN11592"/>
        <property type="gene ID" value="CG723_11930"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.130">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013517">
        <property type="entry name" value="FG-GAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013519">
        <property type="entry name" value="Int_alpha_beta-p"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028994">
        <property type="entry name" value="Integrin_alpha_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01839">
        <property type="entry name" value="FG-GAP"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00191">
        <property type="entry name" value="Int_alpha"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69318">
        <property type="entry name" value="SSF69318"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51470">
        <property type="entry name" value="FG_GAP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014650736" evidence="5">
        <location>
            <begin position="31"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="405"/>
            <end position="424"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PJN11592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="492" mass="48974" checksum="E3ECC93BBB793EF3" modified="2018-04-25" version="1">MRKNRSAALAAASFLLLSGAAIATAPSAYAGTPGGTHAGDRNSDFNGDGYEDVLVGAPGATVSGKKGAGLVTVQYGSSRGIGTTHVARFSQSTSGVAGAAETGDAFGKAVATGDLDGDGYDDAVVGIPGEDIGTTADAGGVAILWGSKAGLTGAASDWLETQEPTAGEKFGTGVTAAHFTNDTPGDVIAVLDRDDLELFAYDSAPQPASKAPLERRSTSRLSKLADARDIVPMSLTTGDYDNNGFADLVVSGVTAGSEPGHGWSSYLSGHADGLTYERDLRGGPVAASGDINRDGYDDLVTGEPNSPDDGGASMTGGLVGVRLGGPEGPSSDVQWWTQDSAGVPGTAERGDGWGTDLSVADTNGDGYADVAIGAAGEDIGTVADAGAVWVLRGAATGLTATGAQSWDQNSANVPGAPEKGDKWGGQVRLTDPNRDGRFGLLAAAPGENTNDGVVWVFSAGSGGVTASGSWTYGAGSLGAPSADAMFGAAIDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JXL9</accession>
    <name>A0A2M9JXL9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Cyclase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CG723_12095</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN11619.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN11619">
        <property type="protein sequence ID" value="PJN11619"/>
        <property type="gene ID" value="CG723_12095"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019587">
        <property type="entry name" value="Polyketide_cyclase/dehydratase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10604">
        <property type="entry name" value="Polyketide_cyc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PJN11619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="178" mass="19809" checksum="A845208D7563AB6A" modified="2018-04-25" version="1">MEWTGARYADRPTVEVRRRVQASPERVWEFVSDIDLMPTLSAELQSVAWLDGAVGPTLGARFLGRSKHESLGEWETTSYVVACEAPREFAWGVEDPEQPSALWKFTLTPLDDGGTELAQWMQLGPGRSGLSYAIDAMPEKEQKIVFVRLREFERNITATLDAIKDLAEGGPAPEGRGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JXZ6</accession>
    <name>A0A2M9JXZ6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CG723_12915</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN11753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN11753">
        <property type="protein sequence ID" value="PJN11753"/>
        <property type="gene ID" value="CG723_12915"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PJN11753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="123" mass="13940" checksum="268554A5AF74338F" modified="2018-04-25" version="1">MPTSAKTPDRRSDRYLGTSERAPRLRHICRVGSAPTAPLRAIRRLRSTSSISTSTCTDRRRPSALRRTLHTGAGFLTEKQRTRLEAVFAVEEHVEVEATWGVYQRTIAAYRDLDEAKGKKLMQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JY78</accession>
    <name>A0A2M9JY78_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Nudix hydrolase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_13425</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN11836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN11836">
        <property type="protein sequence ID" value="PJN11836"/>
        <property type="gene ID" value="CG723_13425"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="SSF55811"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="1">
        <location>
            <begin position="13"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN11836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="125" mass="13139" checksum="5E1BD3DEC3321E7B" modified="2018-04-25" version="1">MALEQTAHGMVQAVVIHNGRLLLVEQPDGSELPSGIPEPAESAEATAARLVYELTGYLVDGSSTLEPQAAQGDPRPAVLCQLLTEDPSDGARLTPEQIHWVPVAAAVDVTPPGAVRNYLEGHTPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JYN6</accession>
    <name>A0A2M9JYN6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">NAD-dependent succinate-semialdehyde dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CG723_14315</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CB01635</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN11981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN11981">
        <property type="protein sequence ID" value="PJN11981"/>
        <property type="gene ID" value="CG723_14315"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016620">
        <property type="term" value="F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="SSF53720"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00687">
        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldedh" evidence="4">
        <location>
            <begin position="34"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PJN11981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="501" mass="52787" checksum="95D6F6D9E5CF89B7" modified="2018-04-25" version="1">MDIDLAVETDLATDIESIVKSPYGEGDLWIGGQWRAASDGRTYPVYDPATGEVVREVGAASAQDAADALDAASAAAEEWRRTPARRRSEILTGAFRLMHEHSDALARLITLENGKAYRDAKAEVGYAAEFFRWFAEEAVRIGSGFGEAPAGGFRHAILKAPVGVTAFVTPWNFPAAMATRKIAPALAAGCPVLLKPAPETPLTALAVAALLAEAGLPAGLLNVLPTDRAPETVSAWLDDERVRKFSFTGSTATGRVLLRQCADHVVNVTMELGGNAPFVVLADADIDAAVRGAMDAKMRGGGEVCIAANRFYVHSDVAAEFTEKFGAAMREVKAGPGLAQGVTLGPMINPTAVERISGLVADAVNRGARIAAQGEVPADGGWYHPATVLTDVPADADILHTEVFGPVAPIVTFTDEEEMLAAANDTAYGLASYVYTRDLARGLRIAERLEAGMVGLNRGLISDTAAPFGGVKQSGIGREGGREGIEAFLETKYVALDWPTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JYQ1</accession>
    <name>A0A2M9JYQ1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cupin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_14490</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN12013.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN12013">
        <property type="protein sequence ID" value="PJN12013"/>
        <property type="gene ID" value="CG723_14490"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025979">
        <property type="entry name" value="ChrR-like_cupin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12973">
        <property type="entry name" value="Cupin_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cupin_7" evidence="1">
        <location>
            <begin position="14"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN12013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="112" mass="12487" checksum="99A33678994545C3" modified="2018-04-25" version="1">MKQELEFFAGDAAPWREAAQPGTEEKVLSRDPDDPAVLTRLVRWLPGLDTSAAGVITHDYVEEVYLLEGELVDLTLGQTFGPGHYASRRPGMRHGPYRTPAGCTMLEIRYRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JYR9</accession>
    <name>A0A2M9JYR9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ABC transporter substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_14505</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN12016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN12016">
        <property type="protein sequence ID" value="PJN12016"/>
        <property type="gene ID" value="CG723_14505"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042597">
        <property type="term" value="C:periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030678">
        <property type="entry name" value="Peptide/Ni-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039424">
        <property type="entry name" value="SBP_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000914">
        <property type="entry name" value="SBP_5_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30290">
        <property type="entry name" value="PTHR30290"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00496">
        <property type="entry name" value="SBP_bac_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002741">
        <property type="entry name" value="MppA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014747728" evidence="1">
        <location>
            <begin position="25"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="domain" description="SBP_bac_5" evidence="2">
        <location>
            <begin position="104"/>
            <end position="471"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN12016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="552" mass="58315" checksum="B5AC304FE9CB6883" modified="2018-04-25" version="1">MTHTSSRRRAAVAAGLVVATIAAAAGCSGATRNTAGGSATADAAKLTLTPATAAAKGELANADWLLEDEPDSLDLDTQGTSAGRVVLTNVCERLYQLQPDMSTKPLLAEKARTPDDKTLVLTLRSGVTFHDGTSMTADDVLWSLKRHADPDMEQGDEFGNIAAMKKTGARQITITFKAPDAMFFKALAGDAGIVWNKEQVEKAGKDFGTPGQPDACTGPYELSGWKSGDSITIRRYDSYWGKKPLTKQVTFRWAADSALVNALTTGAADGAYAESPNTAAALQGKKGIEQHYGPSTASLVLIPTERGGLKDAKVRRALSLALDRKGIAASGYGGMVQPWGTPVGSGAWGYEKPVFEAAQKAVDYAPASPSADDLATAKQLVKESGTDAATPIVIGTDASQGRTVIANAVRAALQRIGLKGQIKTVATSQFEQFYSDPQARADIDVLVGDWYISKADPMGFYDNALSDSSNNWVGFKDAAYDTEVKKALATLDDAERAKLAVDVQKKFTDSAVWISVAQVPSVLVLNTKLTGPPASMAYLYYPWAAELGAKKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JZD5</accession>
    <name>A0A2M9JZD5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alpha/beta hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_14855</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN12242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN12242">
        <property type="protein sequence ID" value="PJN12242"/>
        <property type="gene ID" value="CG723_14855"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="25"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN12242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="270" mass="28309" checksum="50B68809E1CFD255" modified="2018-04-25" version="1">MAELLASSDDAHPITALDDGSGPNLLVVHPGGGDATTWDSVTRHLTDDFRVVRIHRRIYSPGPDTDIALPHSMGVEAADIVAVAELLDSPVLLVGHSSGAVAALEASLLAPSAFAGLCLYEPPMPTRELIAGAAGAHARAALDAGDPVEAMRIHMRDIVRMPANMVDAMFADQQVQAAFAAYAVAQIADDEAIDALGVGVDRFANLETPTTLIEGDLSPTHLRERLADLAATLPNTRIVTLPGQGHIAHLTAPDTLANAIRDMAEQVLHT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JZY2</accession>
    <name>A0A2M9JZY2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">TetR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CG723_04480</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000002">
        <property type="protein sequence ID" value="PJN12317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN12317">
        <property type="protein sequence ID" value="PJN12317"/>
        <property type="gene ID" value="CG723_04480"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039538">
        <property type="entry name" value="BetI_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13977">
        <property type="entry name" value="TetR_C_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0678">Repressor</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="3">
        <location>
            <begin position="15"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="2">
        <location>
            <begin position="38"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PJN12317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="202" mass="22130" checksum="8F8270B924E930BE" modified="2018-04-25" version="1">MSYGDGMGTRTARSEERRAEILRAALEVIAERGYRGATLGAVAERVGLTQQGLLHYFRTKEALLVAVLEERDQWDAVPDGRWRLDLLASLVEYNAMRPGIVQTFSALLGESVTEDHPARPYFTERYGSVRESMAAVLRTEYGERLPGGLTPERAAPLLVAVMDGLQYQWLLDPDSVDMPGAFRDFLALIEGGEGDAGDAGPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K0N1</accession>
    <name>A0A2M9K0N1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Acyl-CoA dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CG723_06625</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CB01635</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000002">
        <property type="protein sequence ID" value="PJN12692.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN12692">
        <property type="protein sequence ID" value="PJN12692"/>
        <property type="gene ID" value="CG723_06625"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016627">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="SSF47203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="SSF56645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0274">FAD</keyword>
    <keyword evidence="3 5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA_dh_N" evidence="8">
        <location>
            <begin position="5"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_M" evidence="7">
        <location>
            <begin position="125"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_1" evidence="6">
        <location>
            <begin position="233"/>
            <end position="372"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PJN12692.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="380" mass="41677" checksum="C82FC5717842CA44" modified="2018-04-25" version="1">MSSVEEFRAEIRAWLADHLVGEFAELRGRGGPGREHEAFEGRLAWERHMAAHGWTCVGWPVEHGGRGASLEEQIAFHEEYALADAPARVNHIGEQLLGPTLIAFGTEGQKERFLPPIVAVEELWCQGYSEPDAGSDLANVRTRGALSPDGSQWVVDGQKIWTSLAHEAQWCFVVARTESGSRRHAGLSYLLVPLDQPGVEVRPIVQLTGTSEFNEVFFDGARTDASHVVGEPGDGWRIAMATLGFERGVSTLGQQVGFRREWDGLAALARRNGAIAAPLIRDRLVQAWIDLEAMAASARRGVDPSVGKLHWAAWHRGLGELAMDVCGAASTIAAGEPYELDDWQRLFLFCRADTIYAGSDEIQKNIVAERLLGLPKEARV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K0X7</accession>
    <name>A0A2M9K0X7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Tellurium resistance protein TerC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CG723_07140</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CB01635</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TerC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000002">
        <property type="protein sequence ID" value="PJN12778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN12778">
        <property type="protein sequence ID" value="PJN12778"/>
        <property type="gene ID" value="CG723_07140"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005496">
        <property type="entry name" value="Integral_membrane_TerC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022369">
        <property type="entry name" value="Integral_membrane_TerC_rswitch"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30238:SF0">
        <property type="entry name" value="PTHR30238:SF0"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03741">
        <property type="entry name" value="TerC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03718">
        <property type="entry name" value="R_switched_Alx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="37"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="67"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="102"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="130"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="192"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="225"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="253"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="288"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="318"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PJN12778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="341" mass="37253" checksum="1B718E45D47597CD" modified="2018-04-25" version="1">MDVSMTLWVLTILGLVALIAVDFFIGRKPHDVSIKEAGIWTVVWIVLAALFGIGLLIWGNSQASGEFFAGFITEKSLSVDNLFVFILIMAKFSVPSQLQQRVLLFGVLIALVLRAIFIAAGAAVIANFSWVFYIFGAFLIYTAWKLIQEAMSDDEEDEFEENRLLKSIEKKFGVADRYHGTKLFIRVNGKRILTPLMVVMLAIGTTDVLFAMDSIPAIFGLTQDPYIVFTANAFALMGLRQLYFLIGGLLRKLVYLSYGLSVILGFIGVKLVLHALHESGVHVPEISIPVSLAVICGVLAVTTIASLIASKKQAQKQALDGGDDDQDGDATDGARKDSIKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K0Y7</accession>
    <name>A0A2M9K0Y7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Acyl-CoA dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CG723_06600</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CB01635</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000002">
        <property type="protein sequence ID" value="PJN12687.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN12687">
        <property type="protein sequence ID" value="PJN12687"/>
        <property type="gene ID" value="CG723_06600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016627">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="SSF47203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="SSF56645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA_dh_N" evidence="4">
        <location>
            <begin position="6"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_1" evidence="3">
        <location>
            <begin position="212"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PJN12687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="346" mass="36506" checksum="53EEC38A4A364285" modified="2018-04-25" version="1">MKFTREQNELRSAVRAVLTHHEGATAWVPLTEAVGAAGLGVPEEYGGVGGGTLETYVVMEELGRTLSPVPYLASTILATQALVASGNARACAELLPKLADGTAVGALAWAEDGSWEPRALNARVRAGRLTGVKEHVLTGPGRPDTLLVLAQGEEGPALYQVTCADSEFTPLPTMDETRPQARIAFDGTPDAELLAADGERILSRVRDLACTALAAEQMGAATQALADTIEYAKNRVQFGRPIGSFQAVKHRIADLHVELEAARSLAQAAAHSNAAPHLAAAAKAACSQAYTNIAGEMIQLHGGIGITWEHQAHRHLKRAHSARLLFGAPAEHRQRLAAGLDLTPVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K150</accession>
    <name>A0A2M9K150_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Glucose-6-phosphate isomerase</fullName>
            <shortName evidence="7">GPI</shortName>
            <ecNumber evidence="7">5.3.1.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Phosphoglucose isomerase</fullName>
            <shortName evidence="7">PGI</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Phosphohexose isomerase</fullName>
            <shortName evidence="7">PHI</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">pgi</name>
        <name evidence="9" type="ORF">CG723_07250</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CB01635</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the reversible isomerization of glucose-6-phosphate to fructose-6-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 7 8">
            <text>alpha-D-glucose 6-phosphate = beta-D-fructose 6-phosphate</text>
            <dbReference type="Rhea" id="RHEA:11816"/>
            <dbReference type="ChEBI" id="CHEBI:57634"/>
            <dbReference type="ChEBI" id="CHEBI:58225"/>
            <dbReference type="EC" id="5.3.1.9"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="7">Carbohydrate biosynthesis; gluconeogenesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 7 8">Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 2/4.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7 8">Belongs to the GPI family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.9" evidence="7"/>
    <dbReference type="EMBL" id="NNBL01000002">
        <property type="protein sequence ID" value="PJN12800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN12800">
        <property type="protein sequence ID" value="PJN12800"/>
        <property type="gene ID" value="CG723_07250"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00181"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00138"/>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097367">
        <property type="term" value="F:carbohydrate derivative binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004347">
        <property type="term" value="F:glucose-6-phosphate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd05015">
        <property type="entry name" value="SIS_PGI_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05016">
        <property type="entry name" value="SIS_PGI_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00473">
        <property type="entry name" value="G6P_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001672">
        <property type="entry name" value="G6P_Isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023096">
        <property type="entry name" value="G6P_Isomerase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018189">
        <property type="entry name" value="Phosphoglucose_isomerase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046348">
        <property type="entry name" value="SIS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035476">
        <property type="entry name" value="SIS_PGI_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035482">
        <property type="entry name" value="SIS_PGI_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11469">
        <property type="entry name" value="PTHR11469"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00342">
        <property type="entry name" value="PGI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00662">
        <property type="entry name" value="G6PISOMERASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53697">
        <property type="entry name" value="SSF53697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00174">
        <property type="entry name" value="P_GLUCOSE_ISOMERASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51463">
        <property type="entry name" value="P_GLUCOSE_ISOMERASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 7 8" id="KW-0312">Gluconeogenesis</keyword>
    <keyword evidence="4 7 8" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="5 7 8" id="KW-0413">Isomerase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Proton donor" evidence="7">
        <location>
            <position position="359"/>
        </location>
    </feature>
    <feature type="active site" evidence="7">
        <location>
            <position position="390"/>
        </location>
    </feature>
    <feature type="active site" evidence="7">
        <location>
            <position position="514"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00029321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PJN12800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="550" mass="60620" checksum="D0B0346A07D0B970" modified="2018-04-25" version="1">MNAESRTRLNQMPEWTALAKHREELGDVQLRELFAAEPARGSDYTLQVGDLHVDYSKHLVTDETLRLLRELAAATDVFGLRDAMFRGEKINTTEGRAVLHTALRAPRDAVIEVDGVDVVPQVHAVLDKMAAFADRVRSGEWTGHTGKRIKNVVNIGIGGSDLGPAMAYEVLRSFTDRDLTVRFVSNVDGADLHEAVRDLDPAETLFIIASKTFTTIETITNATSARNWLLTGLRAGQEAVAKHFVALSTNAEKVSDFGIDTANMFEFWDWVGGRYSYDSAIGLSLMIAIGPDAFREMLDGFHLVDEHFRTAPAEANAPLLMGLLGIWYGNFHGAQSHAVLPYSHYLSKFTAYLQQLDMESNGKSVTRDGTEVDWQTGPVVWGTPGTNGQHAYYQLIHQGTKLIPADFIGFAEPVADLLPGLVAQHDLLMANFFAQTQALAFGKTPAEVRAEGVPEELVPHKTFRGNHPTTTLLAKRLTPFVLGQFIALYEHKVFVQGAVWNIDSFDQWGVELGKVLAKRIEPALTEGADVPGLDPSTKALVAKYRELRGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K1U0</accession>
    <name>A0A2M9K1U0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Two-component sensor histidine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_00420</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000001">
        <property type="protein sequence ID" value="PJN13102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN13102">
        <property type="protein sequence ID" value="PJN13102"/>
        <property type="gene ID" value="CG723_00420"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011712">
        <property type="entry name" value="Sig_transdc_His_kin_sub3_dim/P"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07730">
        <property type="entry name" value="HisKA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="26"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="50"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="79"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="144"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="domain" description="HisKA_3" evidence="2">
        <location>
            <begin position="194"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN13102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="384" mass="40538" checksum="A1C8BC71A74D3B1E" modified="2018-04-25" version="1">MTSGAWTSWPSREALSREGLTRARRVLARVVRAVALTALVWTAAAERGVHGWTVALAPVALIACGAAAWGFFRTTLEHLLWPSVGLLAVLLGAAFAAEQAGFRGPALVLWCGCAVTALERLPLVAAIPLTAGALTGFAVLNNDAWFTTAVTTIGLCLAGYVLRLDAEARGSAQRLLRQERAARAAEAESAALAERARIAREIHDVLAHSLSAQLVHLEAARLLIERGADLDQIHERVVAARGMARDGLTETRQALSALRGEMTPLEDFLRELVATDGATVSVEGVRRPLSVEASQTVRRVAQEALTNVRKHAPGAKAQVRLEYGTAEVTLEVRDAGSATSAGELTVSGSGYGLLGMRERAELLGGTLVAGPCEEGFAVKLKVPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K1U5</accession>
    <name>A0A2M9K1U5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_00430</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000001">
        <property type="protein sequence ID" value="PJN13104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN13104">
        <property type="protein sequence ID" value="PJN13104"/>
        <property type="gene ID" value="CG723_00430"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007436">
        <property type="entry name" value="DUF485"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04341">
        <property type="entry name" value="DUF485"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="79"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="109"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN13104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="165" mass="18072" checksum="75BFD653AB316C97" modified="2018-04-25" version="1">MEKHDGREAAQTRPGDRGVLGDPWYDALASGWGELDGTGAPAPAVPPQAAPPERSAAAIYLEVQRSAAFQEVRSRYRRFVIPAAAAFFAWYLAYILAATTAPGLMGRPVAGAVNVAMLAGLGQFLSTFLLTWLYSRHARLRRDRAALELRWDTQEMTRVIEGGQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K243</accession>
    <name>A0A2M9K243_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">PaaX family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_00990</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000001">
        <property type="protein sequence ID" value="PJN13199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN13199">
        <property type="protein sequence ID" value="PJN13199"/>
        <property type="gene ID" value="CG723_00990"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012906">
        <property type="entry name" value="PaaX-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013225">
        <property type="entry name" value="PaaX_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011965">
        <property type="entry name" value="PaaX_trns_reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07848">
        <property type="entry name" value="PaaX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08223">
        <property type="entry name" value="PaaX_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF020623">
        <property type="entry name" value="PaaX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PaaX" evidence="1">
        <location>
            <begin position="7"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="domain" description="PaaX_C" evidence="2">
        <location>
            <begin position="170"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN13199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="273" mass="29237" checksum="348A23E285ABF907" modified="2018-04-25" version="1">MSDLHTPRSLIVTLYGAYGRGFPGAVPVAELIRLLGAVGVDAPAVRSCVSRLKRRGLLLPERTGSGAAGYALSPAARQLLDDGDRRIYGAPAGGADGWVLAVFSVPEAERAKRHVLRSRLAGLGFGSAAPGVWIAPAGLHEETRHTLERLGLSAYVDLFRGEHLGFAATADAVARWWDLDRLAALHEAFLDEHAPVLAAWQARSPGDAAPEEAYRDYLLALDSWRHLPYADPGLPAGLLPARWPGTRSASVFRALHERLRNAGAAFTTVNHPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-05-25" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K267</accession>
    <name>A0A2M9K267_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ABC transporter substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_01080</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000001">
        <property type="protein sequence ID" value="PJN13213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN13213">
        <property type="protein sequence ID" value="PJN13213"/>
        <property type="gene ID" value="CG723_01080"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025997">
        <property type="entry name" value="SBP_2_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13407">
        <property type="entry name" value="Peripla_BP_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014683310" evidence="1">
        <location>
            <begin position="28"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="domain" description="Peripla_BP_4" evidence="2">
        <location>
            <begin position="78"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN13213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="373" mass="39308" checksum="A85B8977162E0701" modified="2018-04-25" version="1">MNTRMRRAAVAFCATGMAVSLAACGSAKESGDKGSDKASPKKGDNITVGLLLPENQTARYEKFDKPIIEKQISTLTNGKGKVEYLNAKQEATLQSQQIDTMITKKVDVLILDAVDFKAVAGGVKKAKDAGIPVVAYDRLAEGPISAYTSFDNEEVGKTQGEALLKAMGSKATKSSKIVMMNGAITDPNAAFFKKGALSVLKDKVTVAKSYDTKEWKPENANQNMEGAISAIGKDKIAGVYSANDGMAGGIITALKAAGLSKLPPVTGQDAELAGVQRIVTGDQNMSVFKSYPQEAETVAKMAVSIAKTGKLDSSLETSTVDSGTEKGIPSVIVPVVSLTQDNINDTVIKEGYYTLGEICTPKYKAACDKIGLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K2D9</accession>
    <name>A0A2M9K2D9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Glycogen debranching enzyme GlgX</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">glgX</name>
        <name evidence="5" type="ORF">CG723_01495</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CB01635</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 13 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000001">
        <property type="protein sequence ID" value="PJN13285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN13285">
        <property type="protein sequence ID" value="PJN13285"/>
        <property type="gene ID" value="CG723_01495"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004133">
        <property type="term" value="F:glycogen debranching enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005980">
        <property type="term" value="P:glycogen catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02856">
        <property type="entry name" value="E_set_GDE_Isoamylase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044505">
        <property type="entry name" value="GlgX_Isoamylase_N_E_set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006047">
        <property type="entry name" value="Glyco_hydro_13_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004193">
        <property type="entry name" value="Glyco_hydro_13_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011837">
        <property type="entry name" value="Glycogen_debranch_GlgX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00128">
        <property type="entry name" value="Alpha-amylase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02922">
        <property type="entry name" value="CBM_48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00642">
        <property type="entry name" value="Aamy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="SSF81296"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02100">
        <property type="entry name" value="glgX_debranch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aamy" evidence="4">
        <location>
            <begin position="164"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="464"/>
            <end position="486"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PJN13285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="704" mass="79181" checksum="3391ABFE90A032C3" modified="2018-04-25" version="1">MQVWPGQAYPLGATYDGAGTNFAVFSEAARRIELCLLHDDGSETAVELRESDAFVRHAYLPGIMPGQRYGFRAHGPYTPERGQRCNSSKLLLDPYAKAISGRIDWGEAVYGYPFGSPDKRNDLDSAPHTMTSVVVNPYFDWGDDRPPRTEYHHTVIYEAHVKGLTMTHPALPDELRGTYAALAHPAILDHLTELGVTALELMPVHQFVNDHRLVEMGLNNYWGYNTIGFFAPHNAYASWGDRGQQVLEFKSAVRALHEAGIEVILDVVYNHTAEGNHLGPTLSFRGLDNASYYRLADDRRYYMDTTGTGNSLLMRSPHVLQMIMDSLRYWVTEMHVDGFRFDLAATLARQFHEVDRLSSFFDLVQQDPVVSQVKLIAEPWDVGEGGYQVGNFPPLWTEWNGKYRDTVRDLWRGEPRTLAEFAGRLTGSSDLYQDDGRRPLASINFVTCHDGFTLRDLVSYNEKHNEANGEGNRDGESHNRSWNCGVEGDSDDPGVLGLRNRQIRNFIATLMLSQGVPMLSHGDELGRTQNGNNNAYCLDSELAWVRWPEDGEQDALLAFTRAMARLRRDHPVFRRRRFFHGRPVEGTHDELSDIAWFTPEGEEMTRDDWGAAQARALSVFLNGHAISEPGPRGERISDDSFLLLFNASPDALEFLVPVNHGRQWEVVVDTSLPEGVPHGTGAKVKAGDRLTLLDRSLTVLQRPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K2G8</accession>
    <name>A0A2M9K2G8_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ricin B-type lectin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CG723_01690</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000001">
        <property type="protein sequence ID" value="PJN13318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN13318">
        <property type="protein sequence ID" value="PJN13318"/>
        <property type="gene ID" value="CG723_01690"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021862">
        <property type="entry name" value="DUF3472"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035992">
        <property type="entry name" value="Ricin_B-like_lectins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000772">
        <property type="entry name" value="Ricin_B_lectin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11958">
        <property type="entry name" value="DUF3472"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00652">
        <property type="entry name" value="Ricin_B_lectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00458">
        <property type="entry name" value="RICIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50370">
        <property type="entry name" value="SSF50370"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50231">
        <property type="entry name" value="RICIN_B_LECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014902927" description="Ricin B-type lectin domain-containing protein" evidence="2">
        <location>
            <begin position="37"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="domain" description="Ricin B-type lectin" evidence="3">
        <location>
            <begin position="274"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="366"/>
            <end position="398"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PJN13318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="398" mass="41792" checksum="FA9BB7385C0137C2" modified="2018-04-25" version="1">MTGRFTRSLKRRSVPLLAALGLAAGAGLASAPAANADDAIGTTPGTYTYYSFPSAADGLSEVTWSTTVEKDPGYNANTFWSHQFGFNVGNGAYIGMQRNGGDKPTFLFSVWDSFERKPGSEGSYCLQFGGEGEGSSCRMNHDWEEGHTYTSTVAYEGDGWFGATIHDRTTGESFKLGSVQTPATAIKPTGLIDWVEYFEWNDPRATCYDQPYSEAHFGLPTGTAVDAGAAVSSVTKTKSNPPCAAAVDARPDGSTDQRLALGNSKRAEISAPGDKCLAPRGAAKDGAALTLAACKDNGPGAFEQSWVLAADGTVRLPSNYCLTASDKKSVRITDCAGDIATGGKVTDPAKLWTYNPDRKTLVNQATGRSLARTGPEVKLAPAGPGTQGWNAPVPVSAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K2W0</accession>
    <name>A0A2M9K2W0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Dihydropyrimidinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">hydA</name>
        <name evidence="4" type="ORF">CG723_02540</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CB01635</strain>
        </source>
    </reference>
    <comment type="PTM">
        <text evidence="2">Carbamylation allows a single lysine to coordinate two divalent metal cations.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the metallo-dependent hydrolases superfamily. Hydantoinase/dihydropyrimidinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000001">
        <property type="protein sequence ID" value="PJN13466.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN13466">
        <property type="protein sequence ID" value="PJN13466"/>
        <property type="gene ID" value="CG723_02540"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01314">
        <property type="entry name" value="D-HYD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011778">
        <property type="entry name" value="Hydantoinase/dihydroPyrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01979">
        <property type="entry name" value="Amidohydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="SSF51338"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02033">
        <property type="entry name" value="D-hydantoinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydro-rel" evidence="3">
        <location>
            <begin position="57"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-carboxylysine" evidence="2">
        <location>
            <position position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR611778-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PJN13466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="468" mass="50957" checksum="255440C92E1769C4" modified="2018-04-25" version="1">MSSSRTVIRGGLVVTAADEIHADVLIEDGRIAALAAAGSDAAESWTADRTIDARQKYVIPGGVDAHTHMEMPFGGTFAADTFETGTRAAAWGGTTTIVDFAIQTVGHTLREGLDAWHAKADGNCAIDYGFHMIVSDVHDETLKEMDLLVAEGVTSFKQFMAYPGVFYSDDGQILRAMQRAGDNGGLIMMHAENGIAIDVLVQQALERGETDPRYHGEVRKALLEAEATHRAIKLAQVAGAPLYVVHVSAREALAEIARARDEGLNVFGETCPQYLFLSTDNLAEPDFEGAKYVCSTPLRPKDHQAALWRGLRTNDLQVVSTDHCPFCFTGQKELGRGDFSKIPNGLPGVENRMDLLHQAVVDGHISRRRWIEIACATPARMFGLYPKKGTIAPGADADVVIYDPHAEQVVSADTHHMNVDYSAYEGKRITGRVETVLSRGELVITEREFTGRAGHGVYTARSTCQYLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K313</accession>
    <name>A0A2M9K313_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Aminotransferase</fullName>
            <ecNumber evidence="2">2.6.1.2</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_02245</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.2" evidence="2"/>
    <dbReference type="EMBL" id="NNBL01000001">
        <property type="protein sequence ID" value="PJN13417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN13417">
        <property type="protein sequence ID" value="PJN13417"/>
        <property type="gene ID" value="CG723_02245"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004021">
        <property type="term" value="F:L-alanine:2-oxoglutarate aminotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044249">
        <property type="term" value="P:cellular biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotran_1_2" evidence="1">
        <location>
            <begin position="34"/>
            <end position="392"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN13417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="402" mass="44301" checksum="E65101770D47B267" modified="2018-04-25" version="1">MEFRQSSKLSEVCYEIRGPVIEHADALEEAGHSVLRLNTGNPALFGFEAPEEIVQDMIRMLPQAHGYTDSRGVLSARRAVAQRYQALGLEVGVDDVFLGNGVSELVSMAVQALLEDGDEVLIPAPDFPLWTAVTTLSGGKAVHYICDESADWYPDLDDMAAKITDRTKAVVIINPNNPTGAVYPKEIIEGILDLARRHGLMVLADEIYDQILYDDAVHHSAAALAPDLVVLTFCGLSKTYRVAGFRSGWLVVTGPQQHARNYLEGLTMLASMRLCANAPAQYAIQAALGGRQSIRELTAPGGRLLEQRDKAWEKLNEIPGVSCVKPKGALYAFPRIDPKVHPIVDDEKFVLDLLLREKIQVVQGTGFNWPRPDHFRILTLPYADDLDAAISRIGRFLSGYRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K364</accession>
    <name>A0A2M9K364_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_03105</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000001">
        <property type="protein sequence ID" value="PJN13563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN13563">
        <property type="protein sequence ID" value="PJN13563"/>
        <property type="gene ID" value="CG723_03105"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004104">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02894">
        <property type="entry name" value="GFO_IDH_MocA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GFO_IDH_MocA" evidence="1">
        <location>
            <begin position="15"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="domain" description="GFO_IDH_MocA_C" evidence="2">
        <location>
            <begin position="155"/>
            <end position="395"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN13563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="403" mass="43040" checksum="847120E31D1B632D" modified="2018-04-25" version="1">MGTTQEPGAGPRPLGVGMVGYAFMGAAHSQGWRTVGRVFDLPLQPVLAAVCGRDGQAVRAAADRLGWAAAETDWRALIAREDVDVVDICTPGDSHAEIAVAALEAGKHVLCEKPLANTVDEAEAMVEAAERARARGQLAMAGFNYRRVPATALARRMVEEGRIGALRHVRVSYLQDWLVDPDFPLTWRLKKEYAGSGALGDLGAHAVDLAQYLAGESLVGVSALTETFVRERPILKDTVGASAGLAAGDTGTGRGPVTVDDAALFTARFASGALGSFEATRFASGRKNALRLELNGERGSLAFDLERLNELSFHDHTEPGVSAGFRRILVTEPGHPYLEAWWPPGHGLGYEHTFVHQARDLVHAIASGQQPEPSFAEGLRVQRVLAAVEESALKNSVYTPIPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K3U8</accession>
    <name>A0A2M9K3U8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_03835</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000001">
        <property type="protein sequence ID" value="PJN13808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN13808">
        <property type="protein sequence ID" value="PJN13808"/>
        <property type="gene ID" value="CG723_03835"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041413">
        <property type="entry name" value="MLTR_LBD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17765">
        <property type="entry name" value="MLTR_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="2">
        <location>
            <begin position="27"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN13808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="279" mass="30256" checksum="1717FDABD636230E" modified="2018-04-25" version="1">MQAEPVEAGTGAGPSDRAAQGGLGGALREWRVRRRVSQLELATRAGTTQRHVSFVESGRSVPGRAMVVRLAEALMVPLRERNALLLAAGYAPAYQESHFGGPQLSAVRTALERIMEAHLPYPAVIIDRRADLVAANAAFGALTEGVDPALLSAPVNIARVLLHPRGLAPRIVNLDEWAWHVIDGLHDESVRNSNRALTELVAELEDMVPDRPRQAGPDYLGFAVPLRLRTERGELRLLSTLTHFGTAVDVTLAELKLEAFLPLDQETAALLADAMEGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K432</accession>
    <name>A0A2M9K432_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Amino acid transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CG723_03230</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CB01635</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000001">
        <property type="protein sequence ID" value="PJN13787.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN13787">
        <property type="protein sequence ID" value="PJN13787"/>
        <property type="gene ID" value="CG723_03230"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="7"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="39"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="79"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="115"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="147"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="185"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="219"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="269"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="314"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="339"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="377"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="403"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="445"/>
            <end position="470"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PJN13787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="470" mass="50107" checksum="DCDFA705D57A4421" modified="2018-04-25" version="1">MVIPNGLLLTVGYTVGAIGGWTAITIWCVGALVAFAQNMLFAETAAMFPGMSGGISRYATEGWKRYFAPLGAVASYGYWIGWSFSIAVNGAAIGHLITAQWFPHAPSIPFPGHRIGLPEALAVLAIAGGWACNYFGARLAASVSKAVAALVMCGLAVVVIAPFLRPGSWDASRLTWYHGGSWMTLIVWFYVTAWTTYGTEICASFAPEYRDTARDTAKALRLTSLISLGVFFVVPLATVGSVGEATLRSDPVGAFATAFTQALGGFSDVGVLILIVSMFFGMVSCTADGGRALYGLAREGMTVRQLDKVNRWGVPGRALTLDALVNAAIVVLLGEPLSILIASNFGYLVAMTLAVAGFLLLRKDRPDWPRPIRRARAWIPVAWAILAFNIVIVSVGVTHPSLAGYGGATESFLAVGILLISVVLYAYRRVVQDGQRIAWRIEPPLMPDDEAAPQPPNSATARPTIRSSRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-09-29" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JEH0</accession>
    <name>A0A2M9JEH0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Methionine synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CG723_45620</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000061">
        <property type="protein sequence ID" value="PJN05295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN05295">
        <property type="protein sequence ID" value="PJN05295"/>
        <property type="gene ID" value="CG723_45620"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008705">
        <property type="term" value="F:methionine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.196.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004223">
        <property type="entry name" value="VitB12-dep_Met_synth_activ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037010">
        <property type="entry name" value="VitB12-dep_Met_synth_activ_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02965">
        <property type="entry name" value="Met_synt_B12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56507">
        <property type="entry name" value="SSF56507"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50974">
        <property type="entry name" value="ADOMET_ACTIVATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0170">Cobalt</keyword>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="AdoMet activation" evidence="4">
        <location>
            <begin position="34"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="29"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="32"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PJN05295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="323" mass="35744" checksum="FFDCB40233EEEB8C" modified="2018-04-25" version="1" fragment="single">AFEGLRLMDALIAVKRGVPGATLPELKQRRVKAGSVQIEERPEEGPARSDTSTDNPVPEPPFWGTRVIKGIQLKEYASWLDEGALFKGQWGLKQARTGDGPTYEELVETEGRPRLRGWLDRLQTDNLLEAAVVHGYFRCVSKGDDLILLDEAGSELSRFSFPRQGRGRRLCLADFFRPEESGETDVVGLQVVTVGSRIGEATAGLFESNSYRDYLELHGLSVQLAEALAEYWHARVRSELGIAGGDPDLLDGMFRTEYQGCRYSLGYPACPDLADRAKIATLLAPERIGVVLSEEFQLHPEQSTDAIVLHHPEASYFNAGGRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JF18</accession>
    <name>A0A2M9JF18_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CG723_44410</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000047">
        <property type="protein sequence ID" value="PJN05491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN05491">
        <property type="protein sequence ID" value="PJN05491"/>
        <property type="gene ID" value="CG723_44410"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PJN05491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="281" mass="31182" checksum="2B8E5E8B4C20B703" modified="2018-04-25" version="1">MHVIETAKIPWSLVSKSNRPGRVHRKLVHEGEVSPGVGYTADLVRYEGGHGTFNAPRHKHNFDQIRYTVSGTPDFGHYQVSSEGQSVFFPAGAAYGPETIEEAEILLIQWGEHWVSRAQHDETYAQMQQKGEFRDGYYITVGADGTEHRADGRNAVWEAFNQRKLVYPTPRHPQPVMMEPEGFAWRSIGRGVSTKTLGRFTEDDVYVANYRWDVAGGVLDLTAERTQLLWIIDGGLSVDGVAYEPHTVIFSDFGETTSLVGTVDAHAVVFGLPLPAPVAVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JF62</accession>
    <name>A0A2M9JF62_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CG723_44135</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000046">
        <property type="protein sequence ID" value="PJN05514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN05514">
        <property type="protein sequence ID" value="PJN05514"/>
        <property type="gene ID" value="CG723_44135"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PJN05514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="132" mass="13978" checksum="409021D55637CC50" modified="2018-04-25" version="1">MIILDTGAVKALATGHKALNLLAGNMATTAGDQLRIPALSLMQAEADEEHLHRRVLAFSSVVVDPLDTMAAATVGTMIRDGYGGPDTCHALYCALPRAEFTGMSILLTEDENRYPPGVVTVDINSPGMLGFH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JFJ2</accession>
    <name>A0A2M9JFJ2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CG723_43345</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000043">
        <property type="protein sequence ID" value="PJN05650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN05650">
        <property type="protein sequence ID" value="PJN05650"/>
        <property type="gene ID" value="CG723_43345"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PJN05650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="181" mass="20251" checksum="B54CEE896B60B59E" modified="2018-04-25" version="1">MKVTAYRVFGRRNILREAQHAAPSAADLVAHNVRGRLPRVEIVLTTPQGMGELATRAESSLVPGASPRAVDKNRRIVVRNARRVFGLTTATRNGVLILLNVHKLPHPDLLAVTLVHELVHAMQFSRPGVLERHLDRVRNNLDIAPLSRRELRSLDRHMNADEDEAYRMESALTPQLNAYAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JFS2</accession>
    <name>A0A2M9JFS2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CG723_43360</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000043">
        <property type="protein sequence ID" value="PJN05653.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN05653">
        <property type="protein sequence ID" value="PJN05653"/>
        <property type="gene ID" value="CG723_43360"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046251">
        <property type="entry name" value="DUF6284"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19801">
        <property type="entry name" value="DUF6284"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PJN05653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="89" mass="9718" checksum="5A91018D969CC561" modified="2018-04-25" version="1">MGNIVALQAVVTTDGFDREPTAAELDAIEAEMPVILARVELLDAQIVTLDHTPTELDQRRIRRARRKVLAARRELANRSATLAQTGGVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JFU4</accession>
    <name>A0A2M9JFU4_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Magnesium transport protein CorA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6 7" type="primary">corA</name>
        <name evidence="7" type="ORF">CG723_43160</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CB01635</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Mediates influx of magnesium ions.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Membrane</location>
            <topology evidence="1 6">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the CorA metal ion transporter (MIT) (TC 1.A.35) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000042">
        <property type="protein sequence ID" value="PJN05749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN05749">
        <property type="protein sequence ID" value="PJN05749"/>
        <property type="gene ID" value="CG723_43160"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015087">
        <property type="term" value="F:cobalt ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015095">
        <property type="term" value="F:magnesium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045861">
        <property type="entry name" value="CorA_cytoplasmic_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045863">
        <property type="entry name" value="CorA_TM1_TM2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004488">
        <property type="entry name" value="Mg/Co-transport_prot_CorA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002523">
        <property type="entry name" value="MgTranspt_CorA/ZnTranspt_ZntB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01544">
        <property type="entry name" value="CorA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143865">
        <property type="entry name" value="SSF143865"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144083">
        <property type="entry name" value="SSF144083"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00383">
        <property type="entry name" value="corA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="278"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="309"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU362010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PJN05749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="335" mass="37480" checksum="CC88F8830D2EEB89" modified="2018-04-25" version="1">MRRVIVDCGIYRDGRRTEGPADFSDALAEARVEGHSFVWIGLYEPTEDEFARVSDEFGLHPLAVEDALKAHQRPKLDVYDDSLFVVLKPVVYEPDSDKVSSGEVMLFMGDSFVVTVRHGEGAPLKAVRKRLEADPDVLRHGPTAVLYSIADATVDHYLEVATELQTDMEGLEAEVFSPEGGGSRNTASRIYTFKRQILEFRRATGPLMPPLAKLSGTGPSMGPVPFVNESARPFFRDVSDHLLRVNESVDALDRLVSDILSAHLAQMGVRQNDDMRKISAYAAMVAVPTLIAGVYGMNFDHMPELHWTWSYPLVILLMISLELLLFRTFKRRGWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JFV5</accession>
    <name>A0A2M9JFV5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">ABC transporter substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CG723_42745</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000041">
        <property type="protein sequence ID" value="PJN05758.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN05758">
        <property type="protein sequence ID" value="PJN05758"/>
        <property type="gene ID" value="CG723_42745"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001638">
        <property type="entry name" value="Solute-binding_3/MltF_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00497">
        <property type="entry name" value="SBP_bac_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00062">
        <property type="entry name" value="PBPb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014935549" evidence="2">
        <location>
            <begin position="27"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="domain" description="PBPb" evidence="3">
        <location>
            <begin position="72"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PJN05758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="315" mass="33252" checksum="B7DAA8EF746EE789" modified="2018-04-25" version="1">MSRQRIPAAFALITAATLALTGCGSGDPGTSAGAAAPAGKSDKIPTTDVVKAVKKDEAAAKLLPADVRSSGRLTVGASIGGTPPGAFYLEDGRTAAGQDIDFADAVAKVLGLKLKREAAGFEAILPALGSGKYDLGTGNFGVTDERRRTIDFVTYINDGQGFAVREDSDLKKVTDLRQLCGLNVATGAGTTFEATLEENKHLCTDAGKKAYSVKTYADQSAIWSSLQQGRSDVVMSTINGLRYAVAHQEGLRFLNEYHRLDVGFAFKKGTKLAPAFRAAVNKLIADGTYDKILKKWGTSESAIEKSQISPPEIKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JFV9</accession>
    <name>A0A2M9JFV9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_42915</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000041">
        <property type="protein sequence ID" value="PJN05785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN05785">
        <property type="protein sequence ID" value="PJN05785"/>
        <property type="gene ID" value="CG723_42915"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2840">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025736">
        <property type="entry name" value="PucR_C-HTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042070">
        <property type="entry name" value="PucR_C-HTH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012914">
        <property type="entry name" value="PucR_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13556">
        <property type="entry name" value="HTH_30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07905">
        <property type="entry name" value="PucR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PucR" evidence="1">
        <location>
            <begin position="22"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="domain" description="HTH_30" evidence="2">
        <location>
            <begin position="493"/>
            <end position="551"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN05785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="556" mass="58659" checksum="6D0BAEBFBE6E7D5B" modified="2018-04-25" version="1">MDTQAPHSSAPGPQGGITVQRALELPGLRSGLPEVVAGADRLQRTVRWVHAGEVPNIASLLKGGELLLTTGFGIGTRPAEQRAFVRKLADRGISALVIELGQRFARLPAALVETARTAGLPLVQLHREVPFVTVTEEVHTEIVNGHYALLQRAEEVHRRCTEALLGGGGVPQVLRILAEFSGNPVFLETADGQLLYAAGGEPEVADPLQVWEGMRGKPADRDEPPAGAVLVDVPGGGPGTGSVRARLVLLPVAAPLAPVHRIAAERAASSLAVVLMQARQEEELAARGRGDFLTDLSEGRITPDDAPAQARVLGFKPGGQGPLLPVVMRLPEASVGSVGLSPGGGWAVLARAVAEELAAVGVPVLLGVRPVEGRVPLLLGLRSDSERTAVADRVAAALRAGVERAGMQRAGTQPPVVVVGGAGGWAAAAAGLRHAAETATAAQGLADRPWYDARRLDIDLLLWRLRDHPDLAAFVERAIGPLQAHDRRAKPPLLPTLQTYLAHAGRKAETARELHLNRQTLYNRLARISELLGTDLDDPQTVLALSLALRARRHVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JFZ1</accession>
    <name>A0A2M9JFZ1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">6-phosphogluconate dehydrogenase (Decarboxylating)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">gnd</name>
        <name evidence="5" type="ORF">CG723_43260</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CB01635</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 6-phosphogluconate dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000042">
        <property type="protein sequence ID" value="PJN05752.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN05752">
        <property type="protein sequence ID" value="PJN05752"/>
        <property type="gene ID" value="CG723_43260"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004616">
        <property type="term" value="F:phosphogluconate dehydrogenase (decarboxylating) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019521">
        <property type="term" value="P:D-gluconate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016054">
        <property type="term" value="P:organic acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006098">
        <property type="term" value="P:pentose-phosphate shunt"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004849">
        <property type="entry name" value="6DGDH_YqeC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006114">
        <property type="entry name" value="6PGDH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006115">
        <property type="entry name" value="6PGDH_NADP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006184">
        <property type="entry name" value="6PGdom_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015815">
        <property type="entry name" value="HIBADH-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006183">
        <property type="entry name" value="Pgluconate_DH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11811">
        <property type="entry name" value="PTHR11811"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00393">
        <property type="entry name" value="6PGD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03446">
        <property type="entry name" value="NAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000103">
        <property type="entry name" value="HIBADH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00076">
        <property type="entry name" value="6PGDHDRGNASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01350">
        <property type="entry name" value="6PGD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="SSF48179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00872">
        <property type="entry name" value="gnd_rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00461">
        <property type="entry name" value="6PGD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0311">Gluconate utilization</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="6PGD" evidence="4">
        <location>
            <begin position="160"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008419"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000103-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM01350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PJN05752.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="291" mass="31586" checksum="335B978615E91D41" modified="2018-04-25" version="1">MQLGLIGLGKMGGNMRERIRRAGHTVIGYDRNPEVSDVDSLAELVEKLEGPRVVWVMVPAGAATQSTIDELKELLSPGDIVVDGGNSRWTDDEKHAAELATKGIGFVDAGVSGGVWGLENGYALMVGGDKEHIARVQPVFDALKPEGDFGYVHAGKVGAGHFSKMVHNGIEYAMMQAYAEGWELLEKVDSVTDVREVFRSWQEGTVIRSWLLDLAVNALDDDEHLDKLRGFAADSGEGRWTVEAAIDNAVPLPAITASLFARFASRQDDSPQMKMIAALRNQFGGHAVEKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JG30</accession>
    <name>A0A2M9JG30_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Chorismate mutase</fullName>
            <ecNumber evidence="2">5.4.99.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">aroH</name>
        <name evidence="3" type="ORF">CG723_42835</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>chorismate = prephenate</text>
            <dbReference type="Rhea" id="RHEA:13897"/>
            <dbReference type="ChEBI" id="CHEBI:29748"/>
            <dbReference type="ChEBI" id="CHEBI:29934"/>
            <dbReference type="EC" id="5.4.99.5"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.4.99.5" evidence="2"/>
    <dbReference type="EMBL" id="NNBL01000041">
        <property type="protein sequence ID" value="PJN05773.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN05773">
        <property type="protein sequence ID" value="PJN05773"/>
        <property type="gene ID" value="CG723_42835"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004106">
        <property type="term" value="F:chorismate mutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009073">
        <property type="term" value="P:aromatic amino acid family biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008652">
        <property type="term" value="P:cellular amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02185">
        <property type="entry name" value="AroH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008243">
        <property type="entry name" value="Chorismate_mutase_AroH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035959">
        <property type="entry name" value="RutC-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21164">
        <property type="entry name" value="PTHR21164"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07736">
        <property type="entry name" value="CM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005965">
        <property type="entry name" value="Chor_mut_AroH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55298">
        <property type="entry name" value="SSF55298"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01796">
        <property type="entry name" value="CM_mono_aroH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51167">
        <property type="entry name" value="CHORISMATE_MUT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="1 2" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="1">
        <location>
            <position position="7"/>
        </location>
        <ligand>
            <name>prephenate</name>
            <dbReference type="ChEBI" id="CHEBI:29934"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="89"/>
        </location>
        <ligand>
            <name>prephenate</name>
            <dbReference type="ChEBI" id="CHEBI:29934"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="107"/>
        </location>
        <ligand>
            <name>prephenate</name>
            <dbReference type="ChEBI" id="CHEBI:29934"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR005965-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN05773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="120" mass="12918" checksum="CA221E163C84A1B9" modified="2018-04-25" version="1">MAVRAVRGAVQLERDEAGHMDEQVSELLTAILERNALTSDDLISIWFTATPDLHSDFPAAAARKLGIVDVPLICAQELDIEGALPRVVRVLAHIESELPKSGIAHVYLGAAAALRKDIAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JGC9</accession>
    <name>A0A2M9JGC9_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Phosphoribosylaminoimidazole-succinocarboxamide synthase</fullName>
            <ecNumber evidence="8">6.3.2.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">SAICAR synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">purC</name>
        <name evidence="10" type="ORF">CG723_42455</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CB01635</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate + ATP + L-aspartate = (2S)-2-[5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamido]succinate + ADP + 2 H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:22628"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58443"/>
            <dbReference type="ChEBI" id="CHEBI:77657"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.2.6"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 8">Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the SAICAR synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.6" evidence="8"/>
    <dbReference type="EMBL" id="NNBL01000040">
        <property type="protein sequence ID" value="PJN05807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN05807">
        <property type="protein sequence ID" value="PJN05807"/>
        <property type="gene ID" value="CG723_42455"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00131"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004639">
        <property type="term" value="F:phosphoribosylaminoimidazolesuccinocarboxamide synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00137">
        <property type="entry name" value="SAICAR_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028923">
        <property type="entry name" value="SAICAR_synt/ADE2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001636">
        <property type="entry name" value="SAICAR_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018236">
        <property type="entry name" value="SAICAR_synthetase_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01259">
        <property type="entry name" value="SAICAR_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00081">
        <property type="entry name" value="purC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01057">
        <property type="entry name" value="SAICAR_SYNTHETASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01058">
        <property type="entry name" value="SAICAR_SYNTHETASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 8" id="KW-0436">Ligase</keyword>
    <keyword evidence="5 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 8" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SAICAR_synt" evidence="9">
        <location>
            <begin position="19"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PJN05807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="298" mass="33030" checksum="08F309EB981D0877" modified="2018-04-25" version="1">MSGFVEKPEPQQVPGLVHLHTGKVRDLYRNEAGDLVMVASDRMSAYDWVLPTPIPDKGRVLTQLSLWWFDQLADLVPNHVLSTELPPGAPADWQGRTLICKSLRMVPVECVARGYLTGSGLVEYNDSRTVCGLALPEGLTDGSELPAPIFTPATKAEVGEHDENVSYEEVARQVGAETAAQLRQMTLAVYGRARDIARERGVILADTKFEFGFDGEALILGDEVLTPDSSRFWPAAEWEPGHAQPSFDKQYVRNWLTGPESGWDRKSEQPPPALPQQIVDATRAKYIEAYERLTGVSW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JGG2</accession>
    <name>A0A2M9JGG2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF5134 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_41735</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000037">
        <property type="protein sequence ID" value="PJN05971.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN05971">
        <property type="protein sequence ID" value="PJN05971"/>
        <property type="gene ID" value="CG723_41735"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033458">
        <property type="entry name" value="DUF5134"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17197">
        <property type="entry name" value="DUF5134"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="36"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="62"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="92"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="116"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN05971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="183" mass="18680" checksum="0CF7E164FC7E592D" modified="2018-04-25" version="1">MHGPGSAAWLLVAVCAATGAYCLLRMRSRVEEQRRTAGGEALMGFGMALMAIPAAVVTPLPAAWTVYAAVFGAAALRALWAARSSAHHLHHLVGAFAMAYMAVAMDAAPGGHAGHAAAGAPLVTGLLLLYFAGYVLWSGARLVPVATATGGGPPVSGWGDRPELARACRLSMGIGMVAMLLTM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JGH5</accession>
    <name>A0A2M9JGH5_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 8">Uracil-DNA glycosylase</fullName>
            <shortName evidence="8">UDG</shortName>
            <ecNumber evidence="4 8">3.2.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">ung</name>
        <name evidence="11" type="ORF">CG723_41835</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CB01635</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 8">Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>Hydrolyzes single-stranded DNA or mismatched double-stranded DNA and polynucleotides, releasing free uracil.</text>
            <dbReference type="EC" id="3.2.2.27"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the uracil-DNA glycosylase (UDG) superfamily. UNG family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.2.27" evidence="4 8"/>
    <dbReference type="EMBL" id="NNBL01000037">
        <property type="protein sequence ID" value="PJN05991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN05991">
        <property type="protein sequence ID" value="PJN05991"/>
        <property type="gene ID" value="CG723_41835"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004844">
        <property type="term" value="F:uracil DNA N-glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006284">
        <property type="term" value="P:base-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd10027">
        <property type="entry name" value="UDG-F1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00148">
        <property type="entry name" value="UDG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002043">
        <property type="entry name" value="UDG_fam1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018085">
        <property type="entry name" value="Ura-DNA_Glyclase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005122">
        <property type="entry name" value="Uracil-DNA_glycosylase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036895">
        <property type="entry name" value="Uracil-DNA_glycosylase-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11264">
        <property type="entry name" value="PTHR11264"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03167">
        <property type="entry name" value="UDG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00986">
        <property type="entry name" value="UDG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52141">
        <property type="entry name" value="SSF52141"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00130">
        <property type="entry name" value="U_DNA_GLYCOSYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 8" id="KW-0227">DNA damage</keyword>
    <keyword evidence="7 8" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UDG" evidence="10">
        <location>
            <begin position="53"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="8 9">
        <location>
            <position position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001400"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PJN05991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="225" mass="24419" checksum="7C271B0A87CD2A06" modified="2018-04-25" version="1">MAPRPLHEIVEAGWAKALEPVAGQITAMGEFLRAEIAAGRTYLPAGANVLRAFQQPFDEVRVLIVGQDPYPTPGHAVGLSFSVAPEVRPLPGSLINIYRELNTDLGLPQPSNGDLTPWTQQGVLLLNRALTTAPRRPAAHRGKGWEEVTEQAIRALAARGRPLVSVLWGRDARNLRPLLGDLPSVESAHPSPMSADRGFFGSRPFSRANDLLARQGGQPVDWRLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JH14</accession>
    <name>A0A2M9JH14_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Serine hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_40555</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000034">
        <property type="protein sequence ID" value="PJN06170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN06170">
        <property type="protein sequence ID" value="PJN06170"/>
        <property type="gene ID" value="CG723_40555"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008800">
        <property type="term" value="F:beta-lactamase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030655">
        <property type="term" value="P:beta-lactam antibiotic catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046677">
        <property type="term" value="P:response to antibiotic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045155">
        <property type="entry name" value="Beta-lactam_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000871">
        <property type="entry name" value="Beta-lactam_class-A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35333">
        <property type="entry name" value="PTHR35333"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13354">
        <property type="entry name" value="Beta-lactamase2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Beta-lactamase2" evidence="1">
        <location>
            <begin position="29"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN06170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="297" mass="32112" checksum="D84F68627110841C" modified="2018-04-25" version="1">MVTESELVETITGRAAEVGVQVRLHAADLDSPRQVGIDADEPVVTASVFKVPVAVELARQAADGELDLAERITVPPGHPTASPYGLATFLHDVTMSWYDLAVLMIGISDNVATDLILGKVGKAAVAETLRRLGLPQTAVPHDCGDLLRTIGEDLGIDYQDDERILAVMPAEQLAKLRALTPEETCRTTAAESTRLLGLIWRDEAAPAAACADVRRWLELQVWPHRLRSGFADDDVTISGKTGTLPSLRNEIGVVEYPDGGRYAVGVFTRAVDARSRVPERDAFIGFAAAQAVDWLRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JH71</accession>
    <name>A0A2M9JH71_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ATP/GTP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_40080</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000033">
        <property type="protein sequence ID" value="PJN06221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN06221">
        <property type="protein sequence ID" value="PJN06221"/>
        <property type="gene ID" value="CG723_40080"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020476">
        <property type="entry name" value="Nudix_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00502">
        <property type="entry name" value="NUDIXFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="SSF55811"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="1">
        <location>
            <begin position="199"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN06221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="346" mass="37697" checksum="533B88FEBFC9DB73" modified="2018-04-25" version="1">MIVWINGAFGAGKTTTARELIELIPNSTLFDPDAIGGELAQLLPAKQLAEVTDIQDLRIWRRLVVDTAAALLAEVGGVLVVPATLLRQEYRDEIFGGLAARRIPVRHVLLAPAETILRERIARREIPPETRDGELRVRQWSYDHIEAYRTALATWLTADAHPVDTSALSAYGAAERIAEAVRTGAVEPCDIVQTPEPTGETVAAGVLLFDEEDRVLLVDPTYKAGWEFPGGVVEPGEAPARAGVREVAEETGIQLPVLPGLLVVDWEAPAPPAYGGLRLLFDGGRLDGAEAHRMILPGPELRGWRFVTEQEAAGLMPPVRYERLRWALRARERGAALYLEAGVPVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JHF3</accession>
    <name>A0A2M9JHF3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Oxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_39885</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000032">
        <property type="protein sequence ID" value="PJN06306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN06306">
        <property type="protein sequence ID" value="PJN06306"/>
        <property type="gene ID" value="CG723_39885"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD_binding_3" evidence="2">
        <location>
            <begin position="12"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="149"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN06306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="607" mass="64280" checksum="A2454B86CD3B1FEB" modified="2018-04-25" version="1">MSTGPAAPGPAVLVVGAGPVGLTAAHELARRGLRVRLVDAASGPSRTSRAVAVHPRTLETFDQMGTVDGILRHGRRNRAFTMYAGGRRLVRLDADYTSMPTRHPYSVIIEQTRTEAVLREAVARLGVEVEWGVRLAGFEQDGTGVRARLTRADGTGETGQTEQTEQRGERGETGETEEICTVPWLVGCDGGHSTVRKALGLPLLGESRDTWMLADAPVSTDLPPDSIYWVHTGGQALMMVPYAREGHWRLLDTAPDRPDATGAAERFTAKLSRGLGSAVRVGDPEWTSVFTFQQRMVPRMHEGRVFVAGDAAHVHSPASGQGMNTGVQEAYNLAWKLAMVHRGYAERPLLDTYGEERVPVGKALLGSTRTATSLVQFKNALAAVALPVVFSVVRNLPPLRRAIQRKVLGGMSGLRLGYARSSLTTGGGPEPVPIVTPVASPVMVPRRGHVPAPGERVSGAATVSDALVRELRDVRWTLLVAPGGHDADGVPVRAARDAAGQHGAWLSVRSVGGSGAGPRPLPDPDGALCAALGLAAGSWALVRPDGYLAARGDFLTAGALAEALAPVRPRAGDRAAPIKRRSGGFRAVQDTVETETITGAMEMESTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JI25</accession>
    <name>A0A2M9JI25_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alpha/beta hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_39750</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000031">
        <property type="protein sequence ID" value="PJN06407.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN06407">
        <property type="protein sequence ID" value="PJN06407"/>
        <property type="gene ID" value="CG723_39750"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00111">
        <property type="entry name" value="ABHYDROLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="26"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN06407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="255" mass="26960" checksum="23A4D8BF2A1C9493" modified="2018-04-25" version="1">MKQARFDSQESHIRWVEADGYGASRVYVHGLGSASTVYHAHIAGRPELAGRRSLFVDLPGHGISDRPADFGYSLDDHADALAAALDASGASGAELVAHSMGGAVAIVLAHRRPDLVSRLVLTEANLDPYPPRVEGSSGIASYGEDEYVTGGGHARVLAKIGPLWAATMRLADPLALHRTAVGLARGTRPIMRRMLMDLDIDRLYLQGARSGELADRAGLEAAGVRVRTVPDAGHNIMFDNAEAFAAAVAGDHVIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JI36</accession>
    <name>A0A2M9JI36_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Isoprenyl transferase</fullName>
            <ecNumber evidence="2">2.5.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_38245</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="2">Binds 2 magnesium ions per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UPP synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.-" evidence="2"/>
    <dbReference type="EMBL" id="NNBL01000028">
        <property type="protein sequence ID" value="PJN06549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN06549">
        <property type="protein sequence ID" value="PJN06549"/>
        <property type="gene ID" value="CG723_38245"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004659">
        <property type="term" value="F:prenyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00475">
        <property type="entry name" value="Cis_IPPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01139">
        <property type="entry name" value="ISPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001441">
        <property type="entry name" value="UPP_synth-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018520">
        <property type="entry name" value="UPP_synth-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036424">
        <property type="entry name" value="UPP_synth-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10291">
        <property type="entry name" value="PTHR10291"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01255">
        <property type="entry name" value="Prenyltransf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64005">
        <property type="entry name" value="SSF64005"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00055">
        <property type="entry name" value="uppS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01066">
        <property type="entry name" value="UPP_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2 3" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="2">
        <location>
            <begin position="34"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="2">
        <location>
            <begin position="78"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="2">
        <location>
            <begin position="208"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="33"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="2">
        <location>
            <position position="81"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="33"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="38"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="50"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="82"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="84"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="202"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="221"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN06549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="253" mass="28475" checksum="64EAD1A4C0640846" modified="2018-04-25" version="1">MNLRDLVYGLYARRVEGRLDHDQVPKHIGVILDGNRRWAKASGGTAAQGHQAGAYKIEEFLGWCAETDVEVVTLWMLSTDNFDRPEEELRPLLGIIEETVRSLAVDGRWRVHHVGTLDLLPARTQTVLKEAEQATADNAGILVNVAVGYGGRQEIADAVRSLLLDHADKGTSLEEIAESVDIDQISKHLYTSGQPDPDLVIRTSGEQRLSGFMLWQSAHSEYYFCEVFWPAFRKVDFLRALRDYAARHRRYGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JIA3</accession>
    <name>A0A2M9JIA3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_38535</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000028">
        <property type="protein sequence ID" value="PJN06598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN06598">
        <property type="protein sequence ID" value="PJN06598"/>
        <property type="gene ID" value="CG723_38535"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN06598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="369" mass="40290" checksum="885D0EE9DB38F5F3" modified="2018-04-25" version="1">MGILWVLMAVVMLGAVLGPYLLRRRGGIRQVAPGSPDAADPAEYGFMRQEDLDVRLPGPDQDLLNVMSVVQRNQDFTAAKQLLAGTGKESEQRWERVQAIAGAAALELAQTPRLGAGWLHAWRAQDLKDPGGAQVFAEFLVQQAWRNAGGEAQADERRIILEEARSACEDAALLAPGDPVPHITHLAVARGLGYSQHDFEQLWLKILDTAPGHMGAHLAGLRYWCEKWHGSRELAFSFAEAAAARAPRGSLLAALPLFALYEHLPDVNLVRSFYQSEVVTKSIHGALFAVQAARPDDPMLAHVRHLLVFFLVRCERWAEAMEQLLHVDGHVGALPWTTGSDPAADYAVYRALAVAGYEANGGSPATLRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JIH7</accession>
    <name>A0A2M9JIH7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Daunorubicin/doxorubicin resistance ABC transporter ATP-binding protein DrrA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CG723_37855</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000027">
        <property type="protein sequence ID" value="PJN06652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN06652">
        <property type="protein sequence ID" value="PJN06652"/>
        <property type="gene ID" value="CG723_37855"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043215">
        <property type="term" value="P:daunorubicin transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1900753">
        <property type="term" value="P:doxorubicin transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005894">
        <property type="entry name" value="DrrA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01188">
        <property type="entry name" value="drrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="7"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="43"/>
            <end position="50"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PJN06652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="316" mass="33573" checksum="D45707E443B7204D" modified="2018-04-25" version="1">MTSTYAVLSEGLEKRYGSGDQVVHALRGLDLAVEEGTVCGLLGPNGAGKTTAVRVLTTLLRPDAGSARVAGHDVLTESAAVRRRIGVTGQYASVDGDLTGRENLRLFARLLRLPRTRADELLDRFGLTAAADRTARSYSGGMRRRLDLAASLLTRPVVLFLDEPTTGLDPHSRNGIWDAVRELTGQGTTVLLTTQYLEEADQLADSVVLIDGGRAAHRGTPAELKAQTGSYAEVVVAEDAALHAAAVVLDQLSGAEPTLDPDRRAVGVVTLDQTLTLPRIVRELDASGVPIVDATLRPPTLDEAFLRLTGGRELVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JIJ0</accession>
    <name>A0A2M9JIJ0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Urea transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CG723_37925</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CB01635</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the urea transporter family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000027">
        <property type="protein sequence ID" value="PJN06663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN06663">
        <property type="protein sequence ID" value="PJN06663"/>
        <property type="gene ID" value="CG723_37925"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015204">
        <property type="term" value="F:urea transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3430.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029020">
        <property type="entry name" value="Ammonium/urea_transptr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004937">
        <property type="entry name" value="Urea_transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10464">
        <property type="entry name" value="PTHR10464"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03253">
        <property type="entry name" value="UT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="35"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="89"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="111"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="190"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="220"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="250"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="273"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="301"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PJN06663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="352" mass="35641" checksum="A105FB383ABFF5AC" modified="2018-04-25" version="1">MRQAKYGPTPGKSPLNWGAGCRQLGVQLLRGQAQVVFLSSVPAGALLTVALFAAGWEYGLYAIAGTALGTATSRLLGADRERVSTGLEGFNACLTALCFAVFLGADHLSTALLAAAGCVVVTVVTAAVVNLLGVWNLPSLTLPYCLLASATTTAAPGFERIWHHGDGLAALTSAATGPTSLGFSDLWHGFFTGFAEIFFMPQWYVGALILAALLVASRRAAAVAGMGSLVGILSAWALGAPAAQIADGTMGYNAILVALALCGVFLEAGPRTLAYAAVGAFTATAATPAMAAVFAPSGGHTFTWPFVLTTFAFLAAARSFPGLRTSAPAPAVPEPMAAGTLSAQPGPAPQAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JJ25</accession>
    <name>A0A2M9JJ25_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Acyl-CoA thioesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CG723_37045</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CB01635</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the acyl coenzyme A hydrolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000025">
        <property type="protein sequence ID" value="PJN06886.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN06886">
        <property type="protein sequence ID" value="PJN06886"/>
        <property type="gene ID" value="CG723_37045"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016790">
        <property type="term" value="F:thiolester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040170">
        <property type="entry name" value="Cytosol_ACT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033120">
        <property type="entry name" value="HOTDOG_ACOT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006683">
        <property type="entry name" value="Thioestr_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11049">
        <property type="entry name" value="PTHR11049"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03061">
        <property type="entry name" value="4HBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="SSF54637"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51770">
        <property type="entry name" value="HOTDOG_ACOT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HotDog ACOT-type" evidence="5">
        <location>
            <begin position="18"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PJN06886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="182" mass="19813" checksum="A705485F28B650D2" modified="2018-04-25" version="1">MTDQARGTESEIPGKPTSASRTTLSHIMTHNDTNLLGTVHGGVIMKLVDDAAGAVAGRHSGGPAVTASMDEMAFLEPVRVGDLVHVKAQVNWTGRTSMEVGVRVLAERWNESTPAQQVGSAYLVFAAVDGDGKPRSVPPVLPESERDKRRCQEAQIRRQHRLARRRAIMELRQQRAADGIED</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JJ75</accession>
    <name>A0A2M9JJ75_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CG723_36060</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">CB01635</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TMEM175 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000024">
        <property type="protein sequence ID" value="PJN06921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN06921">
        <property type="protein sequence ID" value="PJN06921"/>
        <property type="gene ID" value="CG723_36060"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005267">
        <property type="term" value="F:potassium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010617">
        <property type="entry name" value="TMEM175"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06736">
        <property type="entry name" value="TMEM175"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0407">Ion channel</keyword>
    <keyword evidence="9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0630">Potassium</keyword>
    <keyword evidence="6" id="KW-0631">Potassium channel</keyword>
    <keyword evidence="4" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="20"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="57"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="90"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="127"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="169"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PJN06921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="223" mass="24712" checksum="117A387228153611" modified="2018-04-25" version="1">MARRRYEEVPHSDTGRAEAFSDGVLAIVITLLVLHLKPPPIASGGLLTQLLNQWPTYLAYVASYLYIAVVWLNHKAAFQRIKAMTRGLHWANLGVPFSTALLPWPTALVSEAIAEGNPPDDRVAVGLYALIGAMLWVSWMIFFHVLFRHPELLEDSVEETFFHGERLRAFVGALLYAAAGLIGVLTIPALALAIFVLLPLFYGITSHGYAQLQVFGRRPPPKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JJB7</accession>
    <name>A0A2M9JJB7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Peptide ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CG723_36400</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CB01635</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000024">
        <property type="protein sequence ID" value="PJN06970.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN06970">
        <property type="protein sequence ID" value="PJN06970"/>
        <property type="gene ID" value="CG723_36400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="38"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="102"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="138"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="163"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="193"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="218"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="266"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="102"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PJN06970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="300" mass="31830" checksum="5956B62F0B84572D" modified="2018-04-25" version="1">MSDTALATAATAAELEPVGEDTPRGAAVLRELLRKPRFVLSALAILVIALMAAFPRLFTATDPTVCDLKLSKGAPSAAHWFGYDIQGCDYYANVIYGARPSVLVSVSVCVVGFAVACVLGMLAGYFPGFVDSLVSRTADVLFALPGLVAMIVILQAFSSRSVWTIAFVIVLLGWPAGMRLMRSTVLSVRTREYVLASRALGAGAPHILRVHILPNSVAPLLALTTLTVGAAVGTEAALTFLGIGLQPPTISWGLQIAIAASYRDDVHLFLFPALLLTITVMAFMIMGDTVRDALDPKLKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JJL4</accession>
    <name>A0A2M9JJL4_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Transport permease protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CG723_35605</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CB01635</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the ABC-2 integral membrane protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000023">
        <property type="protein sequence ID" value="PJN07060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN07060">
        <property type="protein sequence ID" value="PJN07060"/>
        <property type="gene ID" value="CG723_35605"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046677">
        <property type="term" value="P:response to antibiotic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC_2_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000412">
        <property type="entry name" value="ABC_2_transport"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01061">
        <property type="entry name" value="ABC2_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006648">
        <property type="entry name" value="DrrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51012">
        <property type="entry name" value="ABC_TM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0046">Antibiotic resistance</keyword>
    <keyword evidence="8" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="30"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="61"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="103"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="142"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="229"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="domain" description="ABC2_membrane" evidence="9">
        <location>
            <begin position="13"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PJN07060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="256" mass="27390" checksum="30245833657DD3D9" modified="2018-04-25" version="1">MSTPMSWAVADSWTMTRRELAHWARQPTQIVVGLAFPVMLLLMFGFLIGGGKGVEGEYVDYLVPGMLALTMAFGLEATMLAVTQDLNKGVIDRFRSMPMVNGAVLVGRSAADMLQSAAALLVMTGVGYVIGWRPHGSAGTFLGALGLLLLFRFAMLWIGIHLAMVAGKPELVQAVQILVWPVGFLSNALAEPGSMPGWLGTVVEWNPMSHTATAVRDLFGGPGGEPGHLWAAVLWPLALLAVFFPLAVRKFAALSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JK06</accession>
    <name>A0A2M9JK06_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">CopY family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_35030</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the BlaI transcriptional regulatory family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000022">
        <property type="protein sequence ID" value="PJN07205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN07205">
        <property type="protein sequence ID" value="PJN07205"/>
        <property type="gene ID" value="CG723_35030"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005650">
        <property type="entry name" value="BlaI_family"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34134">
        <property type="entry name" value="PTHR34134"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03965">
        <property type="entry name" value="Penicillinase_R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN07205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="140" mass="14978" checksum="564C3D889E796902" modified="2018-04-25" version="1">MTRDGHDGRRPRRRGQGELETQVLTALCEAPGPVPAAWVQERIGGGLAYTTVVTILTRLLAKSAVTRARDGRSFLWTPAADGAGLAALRMRKVLDGETNREAVLARFVTALPPGDEQLLRDLLEQAERPDAAPGPGEGEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-05-25" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JK71</accession>
    <name>A0A2M9JK71_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ATP-dependent helicase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_34690</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000022">
        <property type="protein sequence ID" value="PJN07271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN07271">
        <property type="protein sequence ID" value="PJN07271"/>
        <property type="gene ID" value="CG723_34690"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140658">
        <property type="term" value="F:ATP-dependent chromatin remodeler activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022138">
        <property type="entry name" value="Helicase_SWF/SNF-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12419">
        <property type="entry name" value="DUF3670"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0347">Helicase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="1">
        <location>
            <begin position="232"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="2">
        <location>
            <begin position="517"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN07271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="686" mass="74848" checksum="C148661778BB2BEC" modified="2018-04-25" version="1" fragment="single">ASAKAFGPRARMDALLALRRAARAWTPLAPLLSAAVPDALDLADEEITDLLGTGARALAAAGVDVHWPRQLARRLSARAVIGPPGEGSPGGESPDRFRTTTPSFLSADALLAFNWRFALGDQELSREELDRLAEANRPVVRLRDQWVLIDPEQARRAREHQDRKVTPIDALGAVLTGSTEVDGRRVDVHPTGWLAELRERLADPEGMAPVGQPAALAADLRDYQLRGLNWLARMTSLGLGACLADDMGLGKTITLIALHLHRQTAPETAAPTLVVCPTSLMGNWQREIERFAPGTPVRRFHGGRRSLEDLDPGEFVLTTYGTMRLDAAQLAGVDWGMVVTDEAQHVKNPHSATAKELRTIGARARVALTGTPVENNLSELWAILDWTTPGLLGKLGTFRTRYARAVEEGKDPGAAQRLSQLVRPFLLRRRKSDPGIAPELPPKTETDRAVSLTTEQTGLYEAVVRETLAEISGADGIARRGLIVKLLTELKQICNHPAQFLKEDAPRIPGRSGKLELLDELLDTILSEDASVLVFTQYVQMGRLIEQHLAARGVASQFLHGGTPITAREAMVGRFQEGEVPVFLLSLKAAGTGLNLTRAEHVVHYDRWWNPAVEAQATDRAYRIGQNRPVQVHRLIAEGTIEDRIADMLVRKRELADAVLGSGEAALTELTDSELADLVELRGGAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-06-02" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JKH5</accession>
    <name>A0A2M9JKH5_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Putative hydro-lyase CG723_34525</fullName>
            <ecNumber evidence="3">4.2.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CG723_34525</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CB01635</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the D-glutamate cyclase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.-" evidence="3"/>
    <dbReference type="EMBL" id="NNBL01000021">
        <property type="protein sequence ID" value="PJN07368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN07368">
        <property type="protein sequence ID" value="PJN07368"/>
        <property type="gene ID" value="CG723_34525"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01830">
        <property type="entry name" value="Hydro_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009906">
        <property type="entry name" value="D-Glu_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038021">
        <property type="entry name" value="Putative_hydro-lyase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016938">
        <property type="entry name" value="UPF0317"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07286">
        <property type="entry name" value="DUF1445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF029755">
        <property type="entry name" value="UCP029755"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160920">
        <property type="entry name" value="SSF160920"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0456">Lyase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01830"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PJN07368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="285" mass="30968" checksum="8433F1EF6892AA64" modified="2018-04-25" version="1">MNRTQDRVTESVTPDSLPTRTELVDSHAHAWSPAEARARIRAGASGPTAGWSRGHTQANLISVPADWAYEMLLFCQRNPKPCPVLDVTDAGAWTTPLAPGADLRTDLPRYRVWEHGELTAEPTDVVGHWRDDLVSFLIGCSFTFEWALSEAGVPMRHIEQGLNVAMYTTSRQCRPAGRLQGPMVVSMRPVPPEHLAAAIRESALLPAVHGSPVHCGEPSGLGIEDLGRPDFGDPVAAQQGDIPVFWACGVTPQAAVMASRPPFAITHAPGRMFLTDARDEKYRVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JKR6</accession>
    <name>A0A2M9JKR6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_33760</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000020">
        <property type="protein sequence ID" value="PJN07464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN07464">
        <property type="protein sequence ID" value="PJN07464"/>
        <property type="gene ID" value="CG723_33760"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014631255" evidence="1">
        <location>
            <begin position="29"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN07464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="333" mass="34871" checksum="C62F7382DAFB2588" modified="2018-04-25" version="1">MQPASRPRFPLARSVPIAAALFVLPACTAGTVDSAGGSGGGAPGPVVRIAVGVDASFAPFFLADAEGLWAKHGVNVDVVQFAKGGEGVDALTAGQVQLAGNSDTTTIGVLAQNPDLRALAVYENSGDYLKAVLGPHVKSPARIRKMAVVPGLSELAATRFLESRGIDPATVDLVTADPAEIPALTKKGDIDAYVLWEPWPAKGEELGARVVATTGDYGLSYQQWLLATSPWLKANSDTAAKVAAALTEATKQAERDPDAAARATKEAAKVPTEQTVKAIREIDFGVRDFTTADLKGYRNTAEFYASTGKVKAAPDVNRAVLGGWLPEHRKEAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JKU0</accession>
    <name>A0A2M9JKU0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Alkyl/aryl-sulfatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CG723_33925</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CB01635</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the metallo-beta-lactamase superfamily. Type III sulfatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000020">
        <property type="protein sequence ID" value="PJN07489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN07489">
        <property type="protein sequence ID" value="PJN07489"/>
        <property type="gene ID" value="CG723_33925"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018741">
        <property type="term" value="F:alkyl sulfatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018909">
        <property type="term" value="P:dodecyl sulfate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07710">
        <property type="entry name" value="arylsulfatase_Sdsa1-like_MBL-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038536">
        <property type="entry name" value="Alkyl/aryl-sulf_dimr_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029229">
        <property type="entry name" value="Alkyl_sulf_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029228">
        <property type="entry name" value="Alkyl_sulf_dimr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044097">
        <property type="entry name" value="Bds1/SdsA1_MBL-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036527">
        <property type="entry name" value="SCP2_sterol-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14864">
        <property type="entry name" value="Alkyl_sulf_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14863">
        <property type="entry name" value="Alkyl_sulf_dimr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55718">
        <property type="entry name" value="SSF55718"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Lactamase_B" evidence="6">
        <location>
            <begin position="118"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="18"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00033751"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PJN07489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="634" mass="69469" checksum="3E1BBEE3009B99B6" modified="2018-04-25" version="1">MAQVVALFLRASSGTEARRRHHPWETEVTTSDTPDSAPDFADRSDFEEADRGLVSPPLSSTVTAEDGRVVWNFDDTAFLDEDCPDTAHPNLWRQSQLCARAGLFEVTEGVFQVRGFDLSNMTLIEGDHGVVVVDPLASAETAAAALELYRSQRGERPVAAVVFTHSHLDHFGGVLGVIGADDDVPVIAPQGFMEHSVAENVYAGAAMLRRGTYYTGANLERGPEGLVGMGLGFTASTGTAGLMAPTVEVRHTGQELTLDGVVFRFQMTPGTEAPSEMNFLLPQRRALCMAENATHNLHNILTLRGAVVRDARIWARYLNEAIELFGHDADVLFASHHWPTWGSDRIRSFLAEQRDVYAYLHDQTLRLLNQGYTGAEIAELIELPPALSAAWHARGYYGSVSHNVKAIYQRYMGWYDGNPASLWEHPPTETAERYVDCMGGLEAVLGKARTYLEEGDLRFAAQLLRHAVFAAPDSADAKELLAETFERLAHGAECATWRNCYLTGAQELRGEVRATSIGGGNMGDALNIEQLFDSLAVRVDGPRAWDHSLTLHWHLSDLGEMYRMTLHNGVLVHTRTTRPADSADLSLTLTKPQLLTLLAGKGLHGVYHSGDLGALDTLLSVLDENDPDFAIVTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JKV3</accession>
    <name>A0A2M9JKV3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Acyl-CoA synthetase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_34030</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000020">
        <property type="protein sequence ID" value="PJN07506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN07506">
        <property type="protein sequence ID" value="PJN07506"/>
        <property type="gene ID" value="CG723_34030"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-binding" evidence="1">
        <location>
            <begin position="9"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding_C" evidence="2">
        <location>
            <begin position="448"/>
            <end position="524"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN07506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="538" mass="58257" checksum="B1F21021129F5975" modified="2018-04-25" version="1">MEYNLADLFESVVDVVPDREALVHIDHPGTGAEHRLTYAGLDAAANRLAHHLIDSGIRPGEHLGLHLYNGIEYLQTVLACLKARIVPVNVNYRYVEEELVYLYRDADLAALVFDAEFTERVAAAQPQTEKLRHLVRVGTPPAGAPPVKAVDFTEAEATGSPERGFGPRSADDLFIIYTGGTTGMPKGVMWRQEDLFFSGLGGGAPTGEPVSRPEELSERVAAGGDGITFFPTPPLMHGTSTLTAFIGFNFGQRLVIHTKFVPEEVLRTVEKERVTSMSLVGDAMLRPLIDALNGPMKGTDCSSMFSVSSSGAIMSETVRAQFQALVPNVMLLNNFGSSESGFNGTATDDSGPEKGFRLRVNSRTQVVDPATYEPVAPGEPGRIAQRGHVPLGYYNDPAKTAETFFQKGDERWVLLGDMATVDEDGIVTVLGRGSQCINTGGEKVYPEEVEQALKSHPDVYDALVAGVPDAKWGNHVAAVVQLRDGAEPPSLDDIQTHCRTRLAGYKIPRQLVLTDRIQRSPSGKADYRWARAVAADGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JKW6</accession>
    <name>A0A2M9JKW6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NAD-dependent dehydratase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_33540</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000020">
        <property type="protein sequence ID" value="PJN07515.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN07515">
        <property type="protein sequence ID" value="PJN07515"/>
        <property type="gene ID" value="CG723_33540"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Epimerase" evidence="1">
        <location>
            <begin position="3"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN07515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="341" mass="35890" checksum="E9927FEB54D85500" modified="2018-04-25" version="1">MRVLVTGGAGFIGSAVVDTLSARGHEVVVLDVRPPGPDAPHPWVVADVRDPAAVESALAGIDAVCHQAAKVGLGKDFADAPDYVSRNDLGTAVLLAAMASAGVRDLVLAGSMVVYGEGRYECERHGVVRPGPRAEADLRDGRFEPACPRCGAALSPGLVGEDAPTDPRNVYATTKLAQEHLASSWARATGGRAVSLRYHNVYGPGMPRDTPYAGVASFFRSALARGEAPRVFEDGRQRRDFVHVHDVAAANALALETMSDRPSDTCVAYNTGSGDPHTVGEMAHALAAAYGGPMPVVTGEYRLGDVRHITADPARLRAELGWRAEVGFEEGMTEFAKAELG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JKY5</accession>
    <name>A0A2M9JKY5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">SigE family RNA polymerase sigma factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CG723_32695</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CB01635</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000019">
        <property type="protein sequence ID" value="PJN07535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN07535">
        <property type="protein sequence ID" value="PJN07535"/>
        <property type="gene ID" value="CG723_32695"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050896">
        <property type="term" value="P:response to stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039425">
        <property type="entry name" value="RNA_pol_sigma-70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014325">
        <property type="entry name" value="RNA_pol_sigma-E_actinobac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013249">
        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43133">
        <property type="entry name" value="PTHR43133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08281">
        <property type="entry name" value="Sigma70_r4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02983">
        <property type="entry name" value="SigE-fam_strep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014734756" evidence="6">
        <location>
            <begin position="16"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r2" evidence="7">
        <location>
            <begin position="57"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4_2" evidence="8">
        <location>
            <begin position="150"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF08281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PJN07535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="213" mass="23470" checksum="1D716A6BAFF5A590" modified="2018-04-25" version="1">MTATMAPVCSSASDAATRSAPRAAMTPHSSRPAPCTPAAHSTPYGPHKSYPSFASYVRARQPVLLRTARSLTANPCDAEDLLQTALTKTYVAWDRIEDHRALDGYVRRALLNTRTSQWRKRKVDEFACDELPEPETVAAADPAEHQALHDAMWRAIMKLPARQRAMVVLRYYEDLSEVQTAEVLGVSVGTVKSAVSRALGKLREDPELRPAQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JL43</accession>
    <name>A0A2M9JL43_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 12">Replicative DNA helicase</fullName>
            <ecNumber evidence="3 12">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CG723_33045</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">CB01635</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Participates in initiation and elongation during chromosome replication; it exhibits DNA-dependent ATPase activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 12">
            <text>ATP + H2O = ADP + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the helicase family. DnaB subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="3 12"/>
    <dbReference type="EMBL" id="NNBL01000019">
        <property type="protein sequence ID" value="PJN07594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN07594">
        <property type="protein sequence ID" value="PJN07594"/>
        <property type="gene ID" value="CG723_33045"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990077">
        <property type="term" value="C:primosome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006269">
        <property type="term" value="P:DNA replication, synthesis of RNA primer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00984">
        <property type="entry name" value="DnaB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.860.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036185">
        <property type="entry name" value="DNA_heli_DnaB-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007692">
        <property type="entry name" value="DNA_helicase_DnaB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007694">
        <property type="entry name" value="DNA_helicase_DnaB-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007693">
        <property type="entry name" value="DNA_helicase_DnaB-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016136">
        <property type="entry name" value="DNA_helicase_N/primase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00772">
        <property type="entry name" value="DnaB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03796">
        <property type="entry name" value="DnaB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48024">
        <property type="entry name" value="SSF48024"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00665">
        <property type="entry name" value="DnaB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51199">
        <property type="entry name" value="SF4_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 12" id="KW-0235">DNA replication</keyword>
    <keyword evidence="11 12" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9 12 15" id="KW-0347">Helicase</keyword>
    <keyword evidence="8 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 12" id="KW-0639">Primosome</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SF4 helicase" evidence="14">
        <location>
            <begin position="225"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="30"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008428"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU362085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="PJN07594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="491" mass="53779" checksum="CB193355D7E1A030" modified="2018-04-25" version="1">MSISEPLDDPWADSGPSDRLPASRQRGSGGRGRGEQHDRGGDGGWDDGAPSFERVPPQDLDAEQSVLGGMLLSKDAIADVVEVIKGHDFYRPAHETIFTAVLDLYAKGEPADPITVAAELTKRGEITKVGGASYLHTLVQTVPTAANAEYYAEIVHERAVLRRLVEAGTRITQMGYAADGDVDEIVNSAQAEIYAVTEQRTSEDYLPLGDIMEGALDEIEAIGSRSGEMTGVPTGFTDFDSLTNGLHPGQMIVIAARPAMGKSTLALDFARAASIKHNLPSVIFSLEMGRNEIAMRLLSAEARVALHHMRSGTMTDEDWTRLARRMPEVSAAPLYIDDSPNLSMMEIRAKCRRLKQRNDIKLVIIDYLQLMQAGGSKRSESRQQEVSDMSRNLKLLAKELEVPVIALSQLNRGPEQRTDKKPMVSDLRESGSIEQDADMVILLHREDAYEKESPRAGEADIIVGKHRNGPTATITVAFQGHYSRFVDMAQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JL86</accession>
    <name>A0A2M9JL86_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_33260</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000019">
        <property type="protein sequence ID" value="PJN07635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN07635">
        <property type="protein sequence ID" value="PJN07635"/>
        <property type="gene ID" value="CG723_33260"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045925">
        <property type="entry name" value="DUF6344"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19871">
        <property type="entry name" value="DUF6344"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014929072" evidence="2">
        <location>
            <begin position="33"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="30"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="72"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="31"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN07635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="112" mass="11821" checksum="610BFE371F73ED60" modified="2018-04-25" version="1">MASNKVIKLWTVLITAFLAVLTAMGLTSPAAAATPVQQTEGTRNAAVSTPAATAVRAPWAFKRSLPPTMKQRIRAEAHGSSPSCRHRPPVDTESGNEFEETAAGISTLHSQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-05-25" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JLA4</accession>
    <name>A0A2M9JLA4_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Enoyl-CoA hydratase 2</fullName>
            <ecNumber evidence="1">4.2.1.119</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Enoyl-CoA hydratase 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CG723_32710</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CB01635</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>a (3R)-3-hydroxyacyl-CoA = a (2E)-enoyl-CoA + H2O</text>
            <dbReference type="Rhea" id="RHEA:26526"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:57319"/>
            <dbReference type="ChEBI" id="CHEBI:58856"/>
            <dbReference type="EC" id="4.2.1.119"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.119" evidence="1"/>
    <dbReference type="EMBL" id="NNBL01000019">
        <property type="protein sequence ID" value="PJN07660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN07660">
        <property type="protein sequence ID" value="PJN07660"/>
        <property type="gene ID" value="CG723_32710"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002539">
        <property type="entry name" value="MaoC-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01575">
        <property type="entry name" value="MaoC_dehydratas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="SSF54637"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="2" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MaoC-like" evidence="6">
        <location>
            <begin position="24"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="153"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00029334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00030115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PJN07660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="178" mass="18079" checksum="765F285C8C6B5A74" modified="2018-04-25" version="1">MDQGEGEAAVAEVAVGVGTELAPLEIPVTRTLIVSGAIASRDYQDVHHDVELAKEKGSPDIFMNILTTNGLVGRYVTDHFGPAAVLRKVAIRLGAPNHPGDTMVLTGTVAEVQEGDAGGSGHWSEPDGGGATVVVRIVGANGLGKHVTGTVTVALPSPPNPPSPTSTPSRPSVSGRPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JLT8</accession>
    <name>A0A2M9JLT8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CG723_30985</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000017">
        <property type="protein sequence ID" value="PJN07834.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN07834">
        <property type="protein sequence ID" value="PJN07834"/>
        <property type="gene ID" value="CG723_30985"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PJN07834.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="95" mass="10237" checksum="4DA4F2B5FAA4BDF0" modified="2018-04-25" version="1">MEKAGILNRRRPPLAPATVDCAPLPTEAFMAHLVFDPDEQSALRADAREHAITDPGVAYVLERLAAEGVDLEQCADWEDLRLQAGLPARDASSAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JM16</accession>
    <name>A0A2M9JM16_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Hydrophobic protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_31655</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000017">
        <property type="protein sequence ID" value="PJN07930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN07930">
        <property type="protein sequence ID" value="PJN07930"/>
        <property type="gene ID" value="CG723_31655"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="26"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN07930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="57" mass="6489" checksum="CFF1F010D29EE0D1" modified="2018-04-25" version="1">MVPIILVLLLALILFGAGFALKALWWIAIIVLVVWLLGFVIRPAASAGKRRGRWYRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JME6</accession>
    <name>A0A2M9JME6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Acylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CG723_30160</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CB01635</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
        <text evidence="5">Binds 1 Ca(2+) ion per dimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S45 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000016">
        <property type="protein sequence ID" value="PJN07967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN07967">
        <property type="protein sequence ID" value="PJN07967"/>
        <property type="gene ID" value="CG723_30160"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016811">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017000">
        <property type="term" value="P:antibiotic biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1400.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.439.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014395">
        <property type="entry name" value="Pen/GL7ACA/AHL_acylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043147">
        <property type="entry name" value="Penicillin_amidase_A-knob"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023343">
        <property type="entry name" value="Penicillin_amidase_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043146">
        <property type="entry name" value="Penicillin_amidase_N_B-knob"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002692">
        <property type="entry name" value="S45"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34218">
        <property type="entry name" value="PTHR34218"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01804">
        <property type="entry name" value="Penicil_amidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001227">
        <property type="entry name" value="Pen_acylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="SSF56235"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0106">Calcium</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0865">Zymogen</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015006587" evidence="6">
        <location>
            <begin position="36"/>
            <end position="742"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="4">
        <location>
            <position position="214"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="284"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="287"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR001227-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR001227-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PJN07967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="742" mass="82349" checksum="9D82AC325C92310D" modified="2018-04-25" version="1">MSHAQNSGVSRRRVLGGAAGLAAAAAGLQTGTAFAKPALPDEARRRRHADRVTITRDDWGVSHIVGETDADAVFGMMYAQAEDDFNRIEQNYLVALGRLAEAEGESAIWQDLRQRLFLDPEALKKDYAKCPAWLRALMRAWADGLNHYLATHPEVRPRVLDRFEPWMPLSFSEGSIGGDIESVLLTQLEAFYDKRDVPMTDEERGLVQREPTGSNGFAIAPSHTRDGHALLLINPHTSFFFRAEQHVTSREGLNAYGAATWGQFFIYQGFNAETGWMHTSSGVDNIDEFAETIVVGADGARSYRYGDELRPVTTKKVTLSFRTAEGGQSKRTFTTYATHHGPIVRETDGKWIACALMNKPVQALQQSFLRTTTRDYAGYLRVAGLKANSSNNTLFADSKGEIAFLMPQFMPVRDDRFDYLKPVSGSDPATDWRGLHSLDSMPQAVNPKNGWAFNTNNWPWTAAGADSPDKADYPRYFDRFGENPRGPQAIRVLSARDDFTPQTLIDAAFDPYLTAFARLLPGLVAAWDQLPEGSGRKRKLAGPIGLLRDWDHRWSADSPATSVAVFWGEDTWALTSQAAADAGMSVWDYIADRASNAQKLGALETAMQRLQRDFGSWRVPWGDINRYQRNDAAIVQEFSDDKPSIPVPFTSSRWGSLASFGAKAYPGTKRYYGTSGNSFVAVVEFGPRLRAWAVTAGGVSGHPDSPHFGDQAERYARGALRPVYFYPEDLAGHVERRYRPGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JMR1</accession>
    <name>A0A2M9JMR1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">GntR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_29550</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000015">
        <property type="protein sequence ID" value="PJN08153.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08153">
        <property type="protein sequence ID" value="PJN08153"/>
        <property type="gene ID" value="CG723_29550"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07377">
        <property type="entry name" value="WHTH_GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1410.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028978">
        <property type="entry name" value="Chorismate_lyase_/UTRA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011663">
        <property type="entry name" value="UTRA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
        <property type="entry name" value="GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07702">
        <property type="entry name" value="UTRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00345">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00866">
        <property type="entry name" value="UTRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64288">
        <property type="entry name" value="SSF64288"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50949">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH gntR-type" evidence="2">
        <location>
            <begin position="6"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="82"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN08153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="250" mass="27140" checksum="2B25BF056CF00A23" modified="2018-04-25" version="1">MTFGEQPAYLRVAGDLRKKIVNGSLPPHTRLPSQARIREEYGVSDTVALEARKVLMAEGLVEGRSGSGTYVRETPVPRRVARSGYRPISGSTPFKQEQADETARGTWESRSEQAEASSAIAERLGVRAGDRVMCTKYVYRDAGEVMMLSTSWEPLAVTGRTPVMLPEEGPLGGCGVVERMSAIDVIVDNVTEEVGARPGLAEELMALGGVPGHVVLVIQRTYFASGRPVETADVVVPADRYRIAYHLPVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JN29</accession>
    <name>A0A2M9JN29_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_28140</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000014">
        <property type="protein sequence ID" value="PJN08278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08278">
        <property type="protein sequence ID" value="PJN08278"/>
        <property type="gene ID" value="CG723_28140"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009937">
        <property type="entry name" value="Phage_holin_3_6"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07332">
        <property type="entry name" value="Phage_holin_3_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="48"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="97"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN08278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="169" mass="17097" checksum="40AA06EA9880B263" modified="2018-04-25" version="1">MSAPDGTPVGAERSIGQLVATATTEMSALVHDEIALAKAQLKQDVKRGAVGGGALAAAGVVLLFSLPMLSFALAYGIQAWTGGHNGEGGWNLGWCFLLSFAANVLVAGLLALIGVVFAKKAKKGKGPQKVAASVKETAGVLGNAKPHPRQVVPANRVGDTVEAVARSSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JNB6</accession>
    <name>A0A2M9JNB6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Alpha/beta hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_28655</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000014">
        <property type="protein sequence ID" value="PJN08358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08358">
        <property type="protein sequence ID" value="PJN08358"/>
        <property type="gene ID" value="CG723_28655"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008236">
        <property type="term" value="F:serine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001375">
        <property type="entry name" value="Peptidase_S9"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00326">
        <property type="entry name" value="Peptidase_S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase_S9" evidence="2">
        <location>
            <begin position="75"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN08358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="290" mass="30309" checksum="1C14B3EA07FC3824" modified="2018-04-25" version="1">MPDDAAARDEAEEASAFSHPVVPPDVTAAYGDHPDQVVDLYAPRDGAESAPLVVLLHGGAWRAPYDRQHLTPFADFLARRGFAVANVEYRRGSSLPQQGGTAPVAGRWPETFDDIAAALDALPGLVREVLPQGDPRRTVVVGHSAGGQLALWAAARHLLPEDAPWRTAAPAPLRGVVALAPIADFVTARDLDVCSGAPAQFLGGKAVFEERLPYADPAALLPTGIATTLVQGRADTTVPYAVAEAYADAAAKAGEVVGLTLLEDVGHFPLIDPAADACAVVAEEIAQLAW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JP55</accession>
    <name>A0A2M9JP55_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CG723_27815</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000013">
        <property type="protein sequence ID" value="PJN08577.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08577">
        <property type="protein sequence ID" value="PJN08577"/>
        <property type="gene ID" value="CG723_27815"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PJN08577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="245" mass="25248" checksum="3A14B72072CCC62C" modified="2018-04-25" version="1">MLDPEEQDPPQGARLVHGVHAEWGIFAGRGPGGVGTGTLGTGALIRVDCLRELGVDGLGGLGGLGGVGGVGGGGDLGGVGVLGGMGGGLAFRVRGCRTGGQRLVGRWPALTGTGHVRAPFGRTARSDFSRDPALDGEPNRFGQIDLAASMKALGTTVKSGGTKGFRDGPGSRQHAARDLGGRFMSLRHPRKRTHLLEMPEVIAIGVPGTVNHGQQRCAPAFRAPRRSLYGQVRRTTLPRAPSFPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JP87</accession>
    <name>A0A2M9JP87_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Short-chain dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CG723_26520</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000012">
        <property type="protein sequence ID" value="PJN08655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08655">
        <property type="protein sequence ID" value="PJN08655"/>
        <property type="gene ID" value="CG723_26520"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PJN08655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="303" mass="31378" checksum="6F77B6BD0C607A1B" modified="2018-04-25" version="1">MGNFLAGKVVAVTGAGRGIGRAVALACAAEGARVVVNDYGVSIEGGEPASEIAESVVKEIEAAGGEAVAVADDISTMAGGQRIVDVALARYGRIDGVVCVAGILRERMLFNMSEQEWDPVVATHLKGTFTVFRAASAVMRKQGSGTLIGFTSGNHQGSVAQANYSAAKGGIISLVRSAALGLHKYGVTANAVAPVARTRMSANVPMELKEIGEPEDVAALVVYLLSERARAEKITGQVYTIAGPKIAVWAQPRELRSGYAEGGWTPDKIADFLPGTVGVDPMPMLAQLEAMAEAAAAKARPNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JPE7</accession>
    <name>A0A2M9JPE7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Exodeoxyribonuclease III</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">xth</name>
        <name evidence="4" type="ORF">CG723_27080</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CB01635</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DNA repair enzymes AP/ExoA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000012">
        <property type="protein sequence ID" value="PJN08748.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08748">
        <property type="protein sequence ID" value="PJN08748"/>
        <property type="gene ID" value="CG723_27080"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008853">
        <property type="term" value="F:exodeoxyribonuclease III activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004808">
        <property type="entry name" value="AP_endonuc_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22748">
        <property type="entry name" value="PTHR22748"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03372">
        <property type="entry name" value="Exo_endo_phos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="SSF56219"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00633">
        <property type="entry name" value="xth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51435">
        <property type="entry name" value="AP_NUCLEASE_F1_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014618169" evidence="2">
        <location>
            <begin position="23"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="domain" description="Endo/exonuclease/phosphatase" evidence="3">
        <location>
            <begin position="13"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007092"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PJN08748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="273" mass="30531" checksum="5D568BDFCDA53728" modified="2018-04-25" version="1">MCRYRALVLTVTSVNVNGLRAAAKKGFVEWLAGTSADVLCLQEVRAEPAQLPEEVREPEGWHVVHAPAGAKGRAGVSLYTRRRPERVQIGFGSEEFDGSGRYVEVDLPGVVVASLYLPSGEVGTERQDEKIRFMGEFLAYLKGLRERAAAEGREVLVCGDWNIAHREADLKNWKSNKKNSGFLPEERDWLGQVLDEADGGYVDVVRSLHPDEEGPYSWWSYRGRAFDNDSGWRIDYHLSTPGLAGRAVKGFVERAATHDERWSDHAPVTVVYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-09-29" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JPG1</accession>
    <name>A0A2M9JPG1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CG723_26950</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CB01635</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000012">
        <property type="protein sequence ID" value="PJN08725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08725">
        <property type="protein sequence ID" value="PJN08725"/>
        <property type="gene ID" value="CG723_26950"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004638">
        <property type="entry name" value="EmrB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00711">
        <property type="entry name" value="efflux_EmrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="49"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="81"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="106"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="139"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="173"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="201"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="233"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="274"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="308"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="341"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="370"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="416"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="453"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="7">
        <location>
            <begin position="15"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="478"/>
            <end position="500"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PJN08725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="500" mass="52707" checksum="CAC79231742D9554" modified="2018-04-25" version="1">MTSPVTTPDRRRWFALAIVMTAAFMDLVDVTIVNIAIPSIQRDAGATVSQIQWITAGYALAFAAGLITGGRLGDIYGRKRLFLIGIAGFTLASALCGFAANPEMLVASRILQGGMAAMMVPQVLSIVHATFPAEERGKVFGLFGMIVGLGAVSGPLLGALLTEWNLFGLEWRPIFLINLPVGIAGLLLGRKFISESKAPRALKLDLVGVVLVTLGLLMLIYPLTRGRELGWPVWGHVVMGSSVLVFGALVAYEKYKTRRDGSPLIELSLFKVKSFAAGIAVQVVFGVALGVFFLVWTMYMQVGLGWTALHAGLTGVPFSIAVSAAAGISVQKLVPKFGRKVLQTGALAMMTGVLIYIWEAGRYGAGITSWQMALPLVVMGVGMGLIVAPLTDAVLSDVPREHAGSASGLINTTQQMGTALGLGLVSVVFFGTIGDHLAPTEVGPAFTDAFSNSLWYVVGVLAVIFLLMFALPGRPAQHVEGGAQDADPTAGPVEKAPELV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JPG8</accession>
    <name>A0A2M9JPG8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Glycerophosphodiester phosphodiesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CG723_27220</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000012">
        <property type="protein sequence ID" value="PJN08772.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08772">
        <property type="protein sequence ID" value="PJN08772"/>
        <property type="gene ID" value="CG723_27220"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.380">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032524">
        <property type="entry name" value="ABC_tran_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032781">
        <property type="entry name" value="ABC_tran_Xtn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037118">
        <property type="entry name" value="Val-tRNA_synth_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16326">
        <property type="entry name" value="ABC_tran_CTD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12848">
        <property type="entry name" value="ABC_tran_Xtn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="6"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="291"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="533"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="38"/>
            <end position="45"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="323"/>
            <end position="330"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PJN08772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="606" mass="66951" checksum="A3D3638D4B03383B" modified="2018-04-25" version="1">MAVNLVNVEAVSKVYGTRALLDGVSLGVSEGDRIGVVGRNGDGKTTLIRMLAKLEEADTGRVTHSGGLRLGVLTQHDSLDPEATVRHEVIGDLADHEWAGNAKIRDVLTGLFGGLDLPGFPQGLDTVIAPLSGGERRRIALAKLLIGEPDLIVLDEPTNHLDVEGISWLAGHLRARRSALVCVTHDRWFLDQVCTRMWDVQKGDVFEYEGGYSDYVFARAERERIAATEETKRQNLMRKELAWLRRGAPARTSKPRYRIEAANELIADVPEPRDKSELMKFASSRLGKTVFDLEDVTVQAGPKVLLKHLTWQLGPGDRIGLVGVNGAGKTSLLRAMAQAARTGGEEQPAAGRVAVGKTVKLAYLSQEVAELNPELRVIQAVQQVRDRVDLGKGREMTAGQLCETFGFNKEKQWTPVGDLSGGERRRLQILRLLMDEPNVLFLDEPTNDLDIETLTQLEDLLDGWPGSMVVISHDRFFIERTTDRVFALLGDATLRMLPRGIDEYLERRRRMEEAVAASMTAAAATPATGTPEKAVSAADARAAKKELQKIERQLDKMSEKETKLHAQIADNATDFAKVAKLDGELRELIGEREELEMRWLELAEDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JPV1</accession>
    <name>A0A2M9JPV1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_25770</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000011">
        <property type="protein sequence ID" value="PJN08901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08901">
        <property type="protein sequence ID" value="PJN08901"/>
        <property type="gene ID" value="CG723_25770"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="51"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="79"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="109"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN08901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="138" mass="14131" checksum="80F44B09EC7DB964" modified="2018-04-25" version="1">MADEEDSGSGSIRRPSWDHPVVSTVALELGGLAVSGLVALVGWPFGWLPDTGFVLIVTGLIAIGPAVELYRGAGPPRRLAVVAALLALATVRLLVAAAVNWAFPALADPGVGILVGYLVALPIGVAVLAWFLTRANVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JQ23</accession>
    <name>A0A2M9JQ23_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Serine hydroxymethyltransferase</fullName>
            <shortName evidence="5">SHMT</shortName>
            <shortName evidence="5">Serine methylase</shortName>
            <ecNumber evidence="5">2.1.2.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">glyA</name>
        <name evidence="8" type="ORF">CG723_25685</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CB01635</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + glycine + H2O = (6S)-5,6,7,8-tetrahydrofolate + L-serine</text>
            <dbReference type="Rhea" id="RHEA:15481"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15636"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="EC" id="2.1.2.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 5 6">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="5">Amino-acid biosynthesis; glycine biosynthesis; glycine from L-serine: step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="5">One-carbon metabolism; tetrahydrofolate interconversion.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the SHMT family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.2.1" evidence="5"/>
    <dbReference type="EMBL" id="NNBL01000011">
        <property type="protein sequence ID" value="PJN08887.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08887">
        <property type="protein sequence ID" value="PJN08887"/>
        <property type="gene ID" value="CG723_25685"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00193"/>
    <dbReference type="UniPathway" id="UPA00288">
        <property type="reaction ID" value="UER01023"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004372">
        <property type="term" value="F:glycine hydroxymethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019264">
        <property type="term" value="P:glycine biosynthetic process from serine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035999">
        <property type="term" value="P:tetrahydrofolate interconversion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00378">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00051">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001085">
        <property type="entry name" value="Ser_HO-MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039429">
        <property type="entry name" value="SHMT-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11680">
        <property type="entry name" value="PTHR11680"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00464">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000412">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="4 5 6" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SHMT" evidence="7">
        <location>
            <begin position="24"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="5">
        <location>
            <begin position="139"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="69"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="71"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="113"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="135"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="218"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="243"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="250"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="370"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="5 6">
        <location>
            <position position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000412-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PJN08887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="422" mass="43668" checksum="8F734B428F0493BC" modified="2018-04-25" version="1">MPVTTEQAPAGATYAHAGFDVLRLQDPEIAEIMLGEAARQATSLQLIAAENFTSPAVLAALGSPLANKYAEGYPGARHHGGCELVDMAERIAVDRARALFGAEHANVQPHSGSSAVLAAYAALLRPGDTVLAMGLSYGGHLTHGSPANFSGRWFDFVPYGVDPESGLIDHDQVRALARAHRPKAIVCGSIAYPRHIDYAAFRDIADDVGAYLIADAAHPIGLVAGGAAPNPVPYADVVCATTHKVLRGPRGGMVLCGAELAARIDRAVFPFTQGGAQMHTIAAKAVAFGEAATPAFAAYARQVVANARVLAAALDAEGLAITTGGTDTHLLTADPTSLGVDGPTARGRLASAGMVLDTCALPFGDGRGLRLGTAAVTTQGMGEPEMARIAVLFSGVLRDEVDPRTARAEVRDLTGRFPPYPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JQA9</accession>
    <name>A0A2M9JQA9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GNAT family N-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_24175</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000010">
        <property type="protein sequence ID" value="PJN09035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN09035">
        <property type="protein sequence ID" value="PJN09035"/>
        <property type="gene ID" value="CG723_24175"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="7"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN09035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="190" mass="21238" checksum="601D569BBCF483E2" modified="2018-04-25" version="1">MEPAEEYVVRPVRSQEWEAVREIRLASLRDPAAPIAFLETYETALARPEEFWRDRAGRFELDGSGHQFVAEGADGRWWGSVTVRVEEAGAPLAFGETSDVRQAHLVGVYVRPEHRGSGVTEALFLAAVEWARSLEGLERVRLYVHEDNARARAFYRRFGFVPSGARVAVPSDPSKCEYEMVLEGSGGNKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JQB4</accession>
    <name>A0A2M9JQB4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DNA mismatch repair protein MutT</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_24290</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000010">
        <property type="protein sequence ID" value="PJN09054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN09054">
        <property type="protein sequence ID" value="PJN09054"/>
        <property type="gene ID" value="CG723_24290"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020084">
        <property type="entry name" value="NUDIX_hydrolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="SSF55811"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00893">
        <property type="entry name" value="NUDIX_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="2">
        <location>
            <begin position="6"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN09054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="152" mass="16815" checksum="1E3A2562D4C167EA" modified="2018-04-25" version="1">MSSGDDTIHAAGCVLWRRSSHDDVPQALHFDRAGDAPIEICLVHRPKYDDWSHPKGKLKRGEEALAAALREVAEETGFQCAPGARLPTTRYIAKGRPKRVDYWAAEATDGGFTPNREVDRVTWLAPAAARHRLSQPRDKTLVDALLDALHLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JQM5</accession>
    <name>A0A2M9JQM5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_24995</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000010">
        <property type="protein sequence ID" value="PJN09170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN09170">
        <property type="protein sequence ID" value="PJN09170"/>
        <property type="gene ID" value="CG723_24995"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029046">
        <property type="entry name" value="LolA/LolB/LppX"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89392">
        <property type="entry name" value="SSF89392"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014618171" evidence="1">
        <location>
            <begin position="26"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN09170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="270" mass="28259" checksum="357B29157EFDB2C2" modified="2018-04-25" version="1">MRAPLPFTAALVTAAALCAGCGAHDDAGDGSAAKSTAAKAAPADAVRAAVKATRATSAHTRQNVEISDGQGQTYRIDITGGFDLDADRGALSVRMPGGPTGRIDEVFADDTVYVRGTGDLAMDGWGSTSRSAAKAHAMLRAPLNDPEYVLEQISAMRQVTESGTENLDKVPATHYRGTLGHSTLTLRTTSKIRDKADEARDYLGSDLPVFADAWIDGKGRIVRARTDLNLGGVRMTVTLSLSQHGKPVRVAVPDAGQTSPVPEFDGPMLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JR31</accession>
    <name>A0A2M9JR31_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Glutathione ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CG723_23545</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000009">
        <property type="protein sequence ID" value="PJN09323.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN09323">
        <property type="protein sequence ID" value="PJN09323"/>
        <property type="gene ID" value="CG723_23545"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015833">
        <property type="term" value="P:peptide transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013563">
        <property type="entry name" value="Oligopep_ABC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08352">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="11"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="50"/>
            <end position="57"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PJN09323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="284" mass="31130" checksum="A0477B4DF2D9060A" modified="2018-04-25" version="1">MTSASASEALLTVKDVRVSFPGKGWRTPRTEVLKGVDLDIRPGETLGLVGESGSGKTTIGRAILGLVPVASGTITLDGERIDTATTARRRALSRDLQVIFQDPYTSLNPTLTVGDTLAEPLLAQGVDAREARGRVDDLLDRVHLPSDAARRLPREFSGGQRQRVAIARALALRPRLVVCDEPVSALDLTTQRTVLDLLLEIQRETGVSYLFVSHDLAVVRCMSHRVAVIHKGEIVETGDTDHVTRSPHHPYTRTLLLSAPVADVVEQRRRRQLRQEPDQPRQAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JRD5</accession>
    <name>A0A2M9JRD5_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF218 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_21915</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000008">
        <property type="protein sequence ID" value="PJN09439.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN09439">
        <property type="protein sequence ID" value="PJN09439"/>
        <property type="gene ID" value="CG723_21915"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06259">
        <property type="entry name" value="YdcF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003848">
        <property type="entry name" value="DUF218"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02698">
        <property type="entry name" value="DUF218"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF218" evidence="1">
        <location>
            <begin position="32"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN09439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="221" mass="24198" checksum="865B185043CD74D7" modified="2018-04-25" version="1">MISTQAWTDARRLWGYHQMGHTLRPCSVAVGLGSHDLGVADAAVDLYKRGMAPLLVFTGATSPTTRDRMPQGEAVHYRERALELGVPSSAILVEPNARNTGENIRFSKAVLKEAGVDVSSVLLISKPYEERRAYATARKLWPEVEIVSASTPMTLDEYVDSIGDARLVIDMLVGALQRLLIYPEQGFVISQPVPNDVLQAYERLCHEGFSSRLLASGKSSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-05-25" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JRN3</accession>
    <name>A0A2M9JRN3_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Biotin carboxylase</fullName>
            <ecNumber evidence="2">6.3.4.14</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">uca</name>
        <name evidence="12" type="ORF">CG723_22600</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">CB01635</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>biotin</name>
            <dbReference type="ChEBI" id="CHEBI:57586"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.14" evidence="2"/>
    <dbReference type="EMBL" id="NNBL01000008">
        <property type="protein sequence ID" value="PJN09536.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN09536">
        <property type="protein sequence ID" value="PJN09536"/>
        <property type="gene ID" value="CG723_22600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004075">
        <property type="term" value="F:biotin carboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005481">
        <property type="entry name" value="BC-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001882">
        <property type="entry name" value="Biotin_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011764">
        <property type="entry name" value="Biotin_carboxylation_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005482">
        <property type="entry name" value="Biotin_COase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000089">
        <property type="entry name" value="Biotin_lipoyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005479">
        <property type="entry name" value="CbamoylP_synth_lsu-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003778">
        <property type="entry name" value="CT_A_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003833">
        <property type="entry name" value="CT_C_D"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011054">
        <property type="entry name" value="Rudment_hybrid_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011053">
        <property type="entry name" value="Single_hybrid_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014084">
        <property type="entry name" value="Urea_COase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02785">
        <property type="entry name" value="Biotin_carb_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00289">
        <property type="entry name" value="Biotin_carb_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00364">
        <property type="entry name" value="Biotin_lipoyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02786">
        <property type="entry name" value="CPSase_L_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02626">
        <property type="entry name" value="CT_A_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02682">
        <property type="entry name" value="CT_C_D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00796">
        <property type="entry name" value="AHS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00797">
        <property type="entry name" value="AHS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00878">
        <property type="entry name" value="Biotin_carb_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="SSF50891"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51230">
        <property type="entry name" value="SSF51230"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51246">
        <property type="entry name" value="SSF51246"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="SSF52440"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00724">
        <property type="entry name" value="urea_amlyse_rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02712">
        <property type="entry name" value="urea_carbox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50979">
        <property type="entry name" value="BC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00188">
        <property type="entry name" value="BIOTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50968">
        <property type="entry name" value="BIOTINYL_LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00866">
        <property type="entry name" value="CPSASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00867">
        <property type="entry name" value="CPSASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0092">Biotin</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Biotin carboxylation" evidence="11">
        <location>
            <begin position="2"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-grasp" evidence="10">
        <location>
            <begin position="121"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="domain" description="Lipoyl-binding" evidence="9">
        <location>
            <begin position="1108"/>
            <end position="1186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PJN09536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="1195" mass="128338" checksum="FE6BDE1B2184CB91" modified="2018-04-25" version="1">MTFDTLLVANRGEIASRIIRTARRIGLRTVAVYSDPDRGAEHVRLADEAVRLGPAPAKDSYLDAALILKAAKDTGAGAVHPGYGFLSEDAGFARSCAEAGLVFVGPTPVQLELFGAKHTARAAAHAAGVPLAPGTGLLPDLDTALAAAEGIGYPVMLKATGGGGGIGMQGCHDADALEDAWERVQRVAAASFSSAGVFLERLVERARHVEVQVFGDGEGRVVTLGDRDCSLQRRNQKVLEEAPAPDLPDAVRKQLTSSARDLCASVNYRSAGTVEFVYDAAREEAYFLEVNTRLQVEHPVTEEIYGVDLVEWMLRLAQGDTTVAGVPLTPRGHAVEARIYAEDPSRDHRPSAGLLTRVAFPEGVRVDTWVETGTEVTTSYDPMLAKVVAHGSDRAEALDRLDAALAATRLDGIETNLGLVRAALQDADVRQAAHSTASLATISDPTPRIEIVTPGTLTTVQDWPGRTGHWQVGVPPCGPMDDLSFRLGNTALGNTEGAPGLECTLQGPSLRFTHPTTVCVTGAPAPVTIDGIAVPQWEPVTVEAGQTLAVGSPDEHGLRTYVLFAGGLDIPEFLGSSATFALGRFGGHGGRALRAGDVLHGGEQRPDTSVVALDRRPAFAGAWYIGAVEGPHAAPEFFTDDDIRDFYAADWKVHFNSARTGVRLVGPRPRWARTDGGEAGLHPSNIHDTPYSVGAVDYTGDMPVLLGPDGPSLGGFVCPATIVTGQRWKLGQLRPGDTVRFVPVTTEAAAGLRRNPAAAPRADREAVVDGGILARLPRTETRPSVTYRRSGDDNLLIEYGPMQLDLALRMRIHALAQALAGQRLDGVEDLTPGIRSLQVRTDPDVLPQEKLLDIARRVEEELPAPDELVVPSRIVHLPLSWDDPATREAIARYMAGVRDDAPWCPWNIEFIRRVNGLETVEDVYRTVFDAEYLVMGLGDVYLGAPVATPLDPRHRLVTTKYNPARTWTAENSVGIGGAYLCVYGMEGPGGYQFVGRTTQVWSGWQQRGAFEPGRPWLLRFFDRIRWYPVEAEELLELRADITSGRFVPRVEEGSFSLAEYQRFLAENAESIAEFRAGQSAAFRAERDAWEAAGEFTREQAATEAAPQPTDVSVPEGGHLVEAEFTASVWQVNVEVGDRVSAGQPLLALEAMKMESRVPAPADGIVTKILTKPGSQVEAGTALVVLAPVETVEAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JS71</accession>
    <name>A0A2M9JS71_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Dihydroxyacetone kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_21100</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000007">
        <property type="protein sequence ID" value="PJN09702.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN09702">
        <property type="protein sequence ID" value="PJN09702"/>
        <property type="gene ID" value="CG723_21100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004371">
        <property type="term" value="F:glycerone kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006071">
        <property type="term" value="P:glycerol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.340">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019986">
        <property type="entry name" value="DAK2_dom-cont_prot_YloV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004007">
        <property type="entry name" value="DhaL_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036117">
        <property type="entry name" value="DhaL_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033470">
        <property type="entry name" value="UPF_DhaK"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13684">
        <property type="entry name" value="Dak1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02734">
        <property type="entry name" value="Dak2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01121">
        <property type="entry name" value="Dak1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01120">
        <property type="entry name" value="Dak2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101473">
        <property type="entry name" value="SSF101473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03599">
        <property type="entry name" value="YloV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51480">
        <property type="entry name" value="DHAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DhaL" evidence="1">
        <location>
            <begin position="8"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN09702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="556" mass="57309" checksum="19BCC3B022CB0203" modified="2018-04-25" version="1">MPQVLDVHAVRAWCALALEALGRDREEIDAINVYPVADGDTGTNLYLTVESAVQAVEAVFTGLEPAPPALPEVVHAMAHGALIGARGNSGTILAQLLRGMAQVLAGDVDGEADHCERADGDGLRRALRRAAESAREAVAHPVEGTVLTVAAAAADAADISGGPGGDCRDVARAAYDGARAALDATPGQLAVLGRAGVVDAGGRGLVAVLGALTEALSGDPVAPPGVRGVHHARVAADQPLECADGEGPAFEVIYLLEADDQAVARLRTRLDGLGDSLVVVGGDGLWNVHVHVDDAGAAVEAGVEAGRPYRIRITHFAVGDAHMTHPTTGSAPAGEPAQRAIVAVVPGEGLAGLYSEAGATVVPERPGEAPGSGELVEAIRRAHAREVVLLPNDAELRHTAAAAAEQARTEGVRVALIPTRSAIQGIAALAVHEKERRFDEDVVAMTSAAGATRYAELAVAERQSWTMAGICQAGDFLGLIDGDVAVIGEDVTRTARTTLDRMLAAGGEMVTLVLGDDVPDEVAERLERHVRETYLAVDTVVYRGGRNSALMLIGVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JSD2</accession>
    <name>A0A2M9JSD2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC transporter substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CG723_21585</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CB01635</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial solute-binding protein 5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000007">
        <property type="protein sequence ID" value="PJN09789.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN09789">
        <property type="protein sequence ID" value="PJN09789"/>
        <property type="gene ID" value="CG723_21585"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042597">
        <property type="term" value="C:periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030678">
        <property type="entry name" value="Peptide/Ni-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039424">
        <property type="entry name" value="SBP_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023765">
        <property type="entry name" value="SBP_5_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000914">
        <property type="entry name" value="SBP_5_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30290">
        <property type="entry name" value="PTHR30290"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00496">
        <property type="entry name" value="SBP_bac_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002741">
        <property type="entry name" value="MppA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01040">
        <property type="entry name" value="SBP_BACTERIAL_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014974288" evidence="3">
        <location>
            <begin position="29"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="domain" description="SBP_bac_5" evidence="4">
        <location>
            <begin position="86"/>
            <end position="415"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PJN09789.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="506" mass="55471" checksum="29B577833DDA5A70" modified="2018-04-25" version="1">MNLPKKSLSAGVLTVALAVTLAACGGSGDNNSSGGSGAYDKNATVNIGSLYEPQNLDNTGGGGQGVTEALNGNVYEGLFKLTDDGKVENLLAKDYKVSGDGLTYTFTLRDGVKFHSGKALTSKDVKYSLEKVIAPDSQSARKSNLEVIKSVDTPDAKTVQVTLKQKSISFVYNLSYVWIINDQAKNLKTTEDGTGPYKLGKWTRGSALSLDRFPGYWGTAATNKQVVLHYYKDATALNNALMTNAVDVVTSEQSPDALDQFKSNQNYKVNDGDSTTKLLLAFNDKAKPFTDVRVRKAVSSAIDDKKLLESVWGGYGKEIGSMVPPTDPWYEDLTKVNAYDPTEARKLLKEAGYAKGFSFTLDTPNYDPHPTAATFIKSQLAKVGITVKINTITPDEWYTKVYKNHDFSATLQEHVNDRDLVWYGNPDFYWGYDNKQVTRWVEDAEKASSTGAQTDLLKKVNRKTAEDAASDWLYLYPQIVVASSKLSGYPVNGLNSQFFAYDIKKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JSD7</accession>
    <name>A0A2M9JSD7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Zinc metalloprotease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CG723_21565</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CB01635</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the peptidase M50B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000007">
        <property type="protein sequence ID" value="PJN09786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN09786">
        <property type="protein sequence ID" value="PJN09786"/>
        <property type="gene ID" value="CG723_21565"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041489">
        <property type="entry name" value="PDZ_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004387">
        <property type="entry name" value="Pept_M50_Zn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008915">
        <property type="entry name" value="Peptidase_M50"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42837">
        <property type="entry name" value="PTHR42837"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17820">
        <property type="entry name" value="PDZ_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02163">
        <property type="entry name" value="Peptidase_M50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="SSF50156"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="11" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="126"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="345"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="407"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="10">
        <location>
            <begin position="149"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PJN09786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="434" mass="46878" checksum="5A4AB3E8BE4706F6" modified="2018-04-25" version="1">MTTLMMILGIVVFAIGLLVSIAWHELGHLSTAKLFKIRVPQYMVGFGPTVWSRKKGDTEYGVKAIPLGGYIRMIGMFPPGPDGKIQSRSTSPFRSMVEDARAAAFEELQPGDETRLFYTRKPWKRVIVMFAGPFMNLILAVGLFFTVLMGFGITQQTTTVSSVQQCVVKQSENRDTCKKSDPASPAAAAGLRAKDKIVSFNGVKTDKWNTLSDEIRANPGRTVDIVVRRDGQEKVLHAKIATNQVAKKDGSGQIVQGEYINAGFLGFSASTGVVRQDFGDSVTWMGDRVGDAVNSLAALPGKIPALWDAAFGDGPREPDSPMGVVGAARVGGEIFNLDIPATQQLGMALMLVAGFNLSLFLFNMLPLLPLDGGHIAGALWESLRRNVAKVFKRPDPGPFDVAKLMPVAYVVAGIFVCFTVLVLIADVVNPVKIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JSM3</accession>
    <name>A0A2M9JSM3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NADPH-dependent FMN reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_19220</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000006">
        <property type="protein sequence ID" value="PJN09875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN09875">
        <property type="protein sequence ID" value="PJN09875"/>
        <property type="gene ID" value="CG723_19220"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005025">
        <property type="entry name" value="FMN_Rdtase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03358">
        <property type="entry name" value="FMN_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52218">
        <property type="entry name" value="SSF52218"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FMN_red" evidence="1">
        <location>
            <begin position="17"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN09875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="206" mass="22358" checksum="52F25338DD805ED6" modified="2018-04-25" version="1">MDTPYTSRGFTVSTPLHVAVLVGSTREGRFAPVVTKWLAGRLAEHGDMTADVVDLAETPLPTVLPAFGQELPQDSKELLAAVSPRLAAADAFVFVTPEYNHSFPASLKNAVDWHNEQWHAKPIAFVSYGGLSGGLRAVEQLRAVMPELNAMTIRNTVSFHNAWAEFDASGEHADPAVEAAAKAMLDQLAWWAHALRDARSVRPYAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JSP7</accession>
    <name>A0A2M9JSP7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Aldehyde dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_19210</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000006">
        <property type="protein sequence ID" value="PJN09873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN09873">
        <property type="protein sequence ID" value="PJN09873"/>
        <property type="gene ID" value="CG723_19210"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="SSF53720"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldedh" evidence="2">
        <location>
            <begin position="25"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN09873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="298" mass="31461" checksum="145DE44F133077BA" modified="2018-04-25" version="1">MSTVERLTVLKTYKLYVGGKFPRSESGRVYEVSDSKDKWLANAPLSSRKDARDAVVAARKAFGGWAGATAYNRGQVLYRVAEMLEGRRDQFVQEVADAEGLSKSKAAAVVDAAVDRWVWYAGWTDKIGQVVGGANPVAGPFFNLSTPEPTGVVAVLAPQKSSFLGLVSVIAPVIATGNTAVVIASETSPLPALSLGEVLATSDVPGGVVNVLSGRTSEIAPTLAAHQDVNAIDLTGADTDLARDLEIAAADNLKRVRRPQTVDTDWTTDPGTDRLTSFLETKTVWHPTGSLGASGSSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-09-29" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JSR0</accession>
    <name>A0A2M9JSR0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CG723_19465</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000006">
        <property type="protein sequence ID" value="PJN09919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN09919">
        <property type="protein sequence ID" value="PJN09919"/>
        <property type="gene ID" value="CG723_19465"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037883">
        <property type="entry name" value="Knr4/Smi1-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160631">
        <property type="entry name" value="SSF160631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PJN09919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="367" mass="40740" checksum="52FD45A920C6064A" modified="2018-04-25" version="1">MCWVALMGAITFGAGEDLSDRLAALVGTLPAWGYIGFRIRREARAIKEDSRLARGERRRREAVMEPDELVDAVTRLVGKGARRFECCEEGHGSGHVCLALSEELGLLELIDGISGRYGASRNLAMRGFADPTVDATTGLPLLAPFGTEVIDMRAWAHADQWIGAGTVRVGDDIRHVVLVAERDVPVVEELSDDATWVERVVAVTGWAGEARTVDWDAVEARVGTRLPTDFKQLAEIFGYGAFDGFLTLYVPESDVPGMDFVENAEHLAGFAARSGTSLWRPYGIHPAPGGLLEWGASEQADQYYWLTEGDDPDRWPVLASQDIADTWTRFDGTAAEFVFRMLTERSHPHSVARYYDRHWFQSFEDEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JT37</accession>
    <name>A0A2M9JT37_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 5">50S ribosomal protein L14</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">rplN</name>
        <name evidence="6" type="ORF">CG723_20280</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CB01635</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3 5">Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Part of the 50S ribosomal subunit. Forms a cluster with proteins L3 and L19. In the 70S ribosome, L14 and L19 interact and together make contacts with the 16S rRNA in bridges B5 and B8.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 4">Belongs to the universal ribosomal protein uL14 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000006">
        <property type="protein sequence ID" value="PJN10056.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003974257.1">
        <property type="nucleotide sequence ID" value="NZ_NNBL01000006.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A2M9JT37"/>
    <dbReference type="EnsemblBacteria" id="PJN10056">
        <property type="protein sequence ID" value="PJN10056"/>
        <property type="gene ID" value="CG723_20280"/>
    </dbReference>
    <dbReference type="GeneID" id="66855990"/>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015934">
        <property type="term" value="C:large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.150.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01367">
        <property type="entry name" value="Ribosomal_L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036853">
        <property type="entry name" value="Ribosomal_L14_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000218">
        <property type="entry name" value="Ribosomal_L14P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005745">
        <property type="entry name" value="Ribosomal_L14P_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019972">
        <property type="entry name" value="Ribosomal_L14P_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11761">
        <property type="entry name" value="PTHR11761"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00238">
        <property type="entry name" value="Ribosomal_L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01374">
        <property type="entry name" value="Ribosomal_L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50193">
        <property type="entry name" value="SSF50193"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01067">
        <property type="entry name" value="rplN_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00049">
        <property type="entry name" value="RIBOSOMAL_L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="1 3 4" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3 5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 5" id="KW-0699">rRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PJN10056.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="122" mass="13370" checksum="49705967D7024784" modified="2018-04-25" version="1">MIQQESRLRVADNTGAKEILTIRVLGGSGRRYAGIGDVIVATVKDAIPGGNVKKGDVVKAVIVRTVKERRRPDGSYIRFDENAAVILKNDGDPRGTRIFGPVGRELREKKFMKIISLAPEVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JT60</accession>
    <name>A0A2M9JT60_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 8">30S ribosomal protein S3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">rpsC</name>
        <name evidence="13" type="ORF">CG723_20300</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">CB01635</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7 8">Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Part of the 30S ribosomal subunit. Forms a tight complex with proteins S10 and S14.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 8 10">Belongs to the universal ribosomal protein uS3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000006">
        <property type="protein sequence ID" value="PJN10060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN10060">
        <property type="protein sequence ID" value="PJN10060"/>
        <property type="gene ID" value="CG723_20300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1140.32">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01309_B">
        <property type="entry name" value="Ribosomal_S3_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004087">
        <property type="entry name" value="KH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015946">
        <property type="entry name" value="KH_dom-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004044">
        <property type="entry name" value="KH_dom_type_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009019">
        <property type="entry name" value="KH_sf_prok-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005704">
        <property type="entry name" value="Ribosomal_S3_bac-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001351">
        <property type="entry name" value="Ribosomal_S3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036419">
        <property type="entry name" value="Ribosomal_S3_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018280">
        <property type="entry name" value="Ribosomal_S3_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07650">
        <property type="entry name" value="KH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00189">
        <property type="entry name" value="Ribosomal_S3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00322">
        <property type="entry name" value="KH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54814">
        <property type="entry name" value="SSF54814"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54821">
        <property type="entry name" value="SSF54821"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01009">
        <property type="entry name" value="rpsC_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50823">
        <property type="entry name" value="KH_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00548">
        <property type="entry name" value="RIBOSOMAL_S3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 8 10" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5 8 10" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="4 8 9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 8" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="KH type-2" evidence="12">
        <location>
            <begin position="38"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="216"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00016776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00024998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01309"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PJN10060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="282" mass="30590" checksum="CCC016FED1B6D842" modified="2018-04-25" version="1">MGQKVNPHGFRLGITTDFKSRWYADKLYKDYVKEDVAIRRMMTSGMERAGISKVEIERTRDRVRVDIHTARPGIVIGRRGAEADRIRGDLEKLTGKQVQLNILEVKNPETDAQLVAQAVAEQLSSRVSFRRAMRKSMQTAMKAGAKGIKIQCGGRLGGAEMSRSEFYREGRVPLHTLRANVDYGFFEAKTTFGRIGVKVWIYKGDVKNIAEVRAENAAARAGNRPARGGGGGADRPARGGGRGGERGGRGRKPQQQTAPAAEAPKADAPAAAAPAESTGTEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JT71</accession>
    <name>A0A2M9JT71_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">SWIM-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CG723_19825</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000006">
        <property type="protein sequence ID" value="PJN09977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN09977">
        <property type="protein sequence ID" value="PJN09977"/>
        <property type="gene ID" value="CG723_19825"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007527">
        <property type="entry name" value="Znf_SWIM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04434">
        <property type="entry name" value="SWIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50966">
        <property type="entry name" value="ZF_SWIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="SWIM-type" evidence="3">
        <location>
            <begin position="58"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="114"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="382"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="138"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PJN09977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="468" mass="49032" checksum="D08EA03451D71B3C" modified="2018-04-25" version="1">MTQQGVRWTADQVLALAPDAPSRKAGSKLGVAGPWSEAGSSGEGLVWGLCKGSGSKPYQTVVDVADAAGPAYKCSCPSRKFPCKHALGLLLLWAGADGSVPDAQTLPDWAEQWAEGRRKRAQTKRETDAAGGSAADPEAARRRAERRAERVTAGASELEQRLADLLRGGLASAEQAGYGMWEETAARMVDAQAPGLAARVRELGSIPASGPGWPVRLLEECALLHLLDSGWLRRDLLPAGLSATVRSRIGLPSSAEGRPTRDRWLVLAQYDRADSRLTTRRTWLYGTESGHTALLLSYGAAGRAPALSLPVGLALDAELCAYAGDGQLRADLGEQFTAPAPSPVRPKGAGVAEAAARYGDALGRDPWLESWPVTLSRVIPTPDGASGSGSGWQLADADDDLARPRPARPASERLALPITPQAASSPGLWRLAALSGGAPVTVFGECGHRGFTPLTAWPEGPGEAVALC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JTR5</accession>
    <name>A0A2M9JTR5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">LysR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_17370</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LysR transcriptional regulatory family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000005">
        <property type="protein sequence ID" value="PJN10177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN10177">
        <property type="protein sequence ID" value="PJN10177"/>
        <property type="gene ID" value="CG723_17370"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005119">
        <property type="entry name" value="LysR_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000847">
        <property type="entry name" value="Tscrpt_reg_HTH_LysR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00126">
        <property type="entry name" value="HTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03466">
        <property type="entry name" value="LysR_substrate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00039">
        <property type="entry name" value="HTHLYSR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50931">
        <property type="entry name" value="HTH_LYSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH lysR-type" evidence="2">
        <location>
            <begin position="2"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN10177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="304" mass="33631" checksum="9705A057C7451865" modified="2018-04-25" version="1">MLDLRQLRYFVAVAEEEHVGRAADRLHISQSPLSRQIAQLEKNLGLTLFERSQQRLRLTSDGRVFLTEATALLRHADRLENLGRRLGRGEEGGLCVGYVGDAMHTGILPQALRALHDERPGIHVALYDLTAAQQFEGLRQRSLDIALVPEAPPETDPDLRSALLLEDPLLLAMPSSHALAGRAEILPEDLDDQPWIAIENSQQPAWRDDFVASCAAAGFTPDIRLEAPEPLTALGLAASGLGMTLVQESMLRGDTPGVTVRELPWFQRSVRLWAAWHQIDLRPVVTSFRATVLTTKDTADDPVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-09-29" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JTU9</accession>
    <name>A0A2M9JTU9_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Urease</fullName>
            <ecNumber evidence="3">3.5.1.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CG723_17860</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CB01635</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>2 H(+) + H2O + urea = CO2 + 2 NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:20557"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16199"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="EC" id="3.5.1.5"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Nitrogen metabolism; urea degradation; CO(2) and NH(3) from urea (urease route): step 1/1.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.5" evidence="3"/>
    <dbReference type="EMBL" id="NNBL01000005">
        <property type="protein sequence ID" value="PJN10258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN10258">
        <property type="protein sequence ID" value="PJN10258"/>
        <property type="gene ID" value="CG723_17860"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00258">
        <property type="reaction ID" value="UER00370"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035550">
        <property type="term" value="C:urease complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016151">
        <property type="term" value="F:nickel cation binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009039">
        <property type="term" value="F:urease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043419">
        <property type="term" value="P:urea catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00407">
        <property type="entry name" value="Urease_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00390">
        <property type="entry name" value="Urease_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.280.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002019">
        <property type="entry name" value="Urease_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036461">
        <property type="entry name" value="Urease_betasu_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008223">
        <property type="entry name" value="Urease_gamma-beta_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002026">
        <property type="entry name" value="Urease_gamma/gamma-beta_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036463">
        <property type="entry name" value="Urease_gamma_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00699">
        <property type="entry name" value="Urease_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00547">
        <property type="entry name" value="Urease_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001225">
        <property type="entry name" value="Urease_gammabeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51278">
        <property type="entry name" value="SSF51278"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54111">
        <property type="entry name" value="SSF54111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00192">
        <property type="entry name" value="urease_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00193">
        <property type="entry name" value="urease_gam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PJN10258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="237" mass="24489" checksum="ECBB533B322A57DD" modified="2018-04-25" version="1">MRLTPTERDRLLLFGAAELARARRARGLRLNVPEATALIADTVCEAARDGARLAEAVAVARKTLGPDDVLPGVPDVVTEIHVEAVFDDGTRLAVVSDPFGGGSLGAQAPGAVLPAAEEPAGQAAPVRTVTVHNTASVPISVTSHFHFFEANPRLDFDRAAAFGMRLAMPAGASTRFAPGTESEVGLLPIGGARVVIGFAGLVDGPLDAPGARRDALRRAAACGYLGARPDDDQEASL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JU49</accession>
    <name>A0A2M9JU49_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glyoxalase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_18425</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000005">
        <property type="protein sequence ID" value="PJN10352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN10352">
        <property type="protein sequence ID" value="PJN10352"/>
        <property type="gene ID" value="CG723_18425"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VOC" evidence="1">
        <location>
            <begin position="8"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN10352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="116" mass="11885" checksum="2F7D779666E198F5" modified="2018-04-25" version="1">MTSSSTQGIKTVLHPVSDLEKAKAVYVALLGAEPTADAPYYVGFDVEGQHIGLVPGGGGMTSPVTYWHVPDIAAKLAEVTAAGAVVKEAAHDVGGGRLVATFTDPDGNVLGLLQDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JUF0</accession>
    <name>A0A2M9JUF0_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PPM-type phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_19045</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000005">
        <property type="protein sequence ID" value="PJN10452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN10452">
        <property type="protein sequence ID" value="PJN10452"/>
        <property type="gene ID" value="CG723_19045"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07228">
        <property type="entry name" value="SpoIIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00331">
        <property type="entry name" value="PP2C_SIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPM-type phosphatase" evidence="1">
        <location>
            <begin position="25"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN10452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="240" mass="25037" checksum="C68B12E15FE62A72" modified="2018-04-25" version="1">MTARSQPVSPLPERVGTLRVSARHLANATVAPVETGPAAAGGDVYGAVESPYGTRLLMGDVMGKGRALARTADSVLCAWRDLAVREARLEGIAVRLHSLVARSDEPDRFVTATLLSVAPDGSAQLVCCGHPPPVLLRDGAAVHAAVPAPAPPLGLLDLHSGWCAAQPVPATAWECMLLYTDGVSEARDARGAFYPLAERAAALENTLLEDFTDALAADLLRHAEGRLQDDASLLAVRAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JUJ9</accession>
    <name>A0A2M9JUJ9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">TetR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_15170</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000004">
        <property type="protein sequence ID" value="PJN10560.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN10560">
        <property type="protein sequence ID" value="PJN10560"/>
        <property type="gene ID" value="CG723_15170"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011075">
        <property type="entry name" value="TetR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16859">
        <property type="entry name" value="TetR_C_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="17"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="40"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN10560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="209" mass="22458" checksum="1C14774C71692052" modified="2018-04-25" version="1">MTERPQHGSARPGGRTARTRAAVLAAALHELDETGFGALTLDKLAARSGVHVSTIRRRWRSVEGVVVDLMAQHSKTIATPDSGEFRQDLYELAEAIAGFHALPRSRNLVEAMVAAAAYDPHIADLVRGAFVARTEVVTQLVRRAVDRGEVPPDTDAYEVIAALSAPFYYRLLIMRGDIDERLVAASAEAAYRSACGGVFGGVDGEEGSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-09-29" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JUT7</accession>
    <name>A0A2M9JUT7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Helicase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CG723_15580</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000004">
        <property type="protein sequence ID" value="PJN10633.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN10633">
        <property type="protein sequence ID" value="PJN10633"/>
        <property type="gene ID" value="CG723_15580"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006935">
        <property type="entry name" value="Helicase/UvrB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04851">
        <property type="entry name" value="ResIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0347">Helicase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="2">
        <location>
            <begin position="1200"/>
            <end position="1373"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="3">
        <location>
            <begin position="1442"/>
            <end position="1584"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="425"/>
            <end position="445"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PJN10633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="1584" mass="176374" checksum="FC7E891DC2A88F6F" modified="2018-04-25" version="1">MQPSDQRVVQTVLEQSSRVLQTYSVDPGLVAEHANGERRITQGGYGDRQLFELVQNAADEISAAPGGRIQVVLTATHLYCANEGDAVTPEGAETILRMSMSKKRGGQIGRFGVGVKSVLVVTDTPEFFSKSGSFGFDRSWSYEKINAVPGVTDRYGENFDAPVLRMARPLDMPTERNTDPVLKELLTWATTVVRLPLLAGADDRLGRDMHGGRAKNHGEIRDEFPVGFQLFSPHVGQVVLEDRRPRPVLRRVLTSHQSDDLHTIDEERTGKAVAKTSWRVFTTTHEPGPAARADAGELHDRVALDLSWAVPALAEDPSTGLYTANARGRGRFWSFFPTKYDMTLSGVLNGAWKTNEDRQNLLDSSPFNQEMIRVAARLVVDSLPSLAPEQDPAAYLPLLPGRVKESISWADEFLTREIWNRAASSPSLPDQDGTLRNPADLQAPPRFKDAKDKAKWLGLWHDCPGRPSNWLHPSADADTLRSGKVEHILGERRQERAGVREWLEALVQCGTAESSKAAIKILAALVESKRPEAEEARKARVILTEEHGFVAPMHGKVFRRTEQGGLRESLVYVVDALAQDSELTHELNVLGVREADVEGRFTSVLDQGFDHYGEAEWQRFWELFRQAGIRQQTYKVLERMSDPRDTLHVRTGDGRFRPIVDCMLPGPVVDVSRDPEIAVDVVFHSDDLPFFAQVGLRPKPSSGVRPSTHEEWFQDYREAVHASHLRGLDSRAPRPAINRLKLEGAPIGGPLHLFRAMSEESRANFLKALPDESVVDNWTRQFGAQANTRQAVPSPIRWMLRKYGVVGTTQGLKPLKEAVGPQLASYHDVLPVADISPEKARKLHLPVTVDEVPPQLWQSLLDAVARSEDDVFVGATYVMLTRFEADFPEDSLTRCRIGDTWGARPDDEITLAVDTTEYRALRAEQLPALLVPSAADAELMVERWGMLRYADVISTETREVPDGDPVLLVDLYPGLRQRLNSTNRSSSVQRCSELEEVIRTPNGTRSAPLKAVRQGDVVKVRVPLERAPMLALIDTGLGLGLRAEGCRAVLELEERMARDSAMQAAVKAVREAQDMVTKIELLIGADALRAGLPEGLVEAEIQEGDGEPTPRRIAQMAFNSHGDGVLQQHARDVQARFPNAPGSYTGTSNAIAFVSDLRLPVSFAGSRTPSPPPFETIDGPQDFPSLHDYQEDLVRNVTTMLDRLAPQRGMLSLPTGAGKTRVTAEAVIRWVKRVRDLTGPLLWIAQTEELCEQAVQSWKFVWSKVGAERPLVISRLWGSNEVGDVVDHPHLVVATDAKLERCLGTDQYDWLRQAALVIVDEAHTAVSKRYTEILGRLGLTQYETERHLLGLTATPFRNNNEDETRRLVSRFGNRRLDEGVFPSGDPYRDLQKWEMLAQVEHRTLEGGQIELTRDEKSHADTMAMLSRSAEQRLADDHARSRRIVDAVAALPSDWPTLLFATSVDHAKYLAAMLNDRGIRSAAVDSTTSTQDRRTRIENFRNNRIRVLTNYGVLTQGFDAPATRVVVVARPVFSKNVYQQMIGRGLRGPKNGGKDTCLILNVSDNITNFDTDLAFAEFEHLWSRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JUX9</accession>
    <name>A0A2M9JUX9_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Oligoribonuclease</fullName>
            <ecNumber evidence="1">3.1.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">orn</name>
        <name evidence="3" type="ORF">CG723_15970</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">3'-to-5' exoribonuclease specific for small oligoribonucleotides.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the oligoribonuclease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="1"/>
    <dbReference type="EMBL" id="NNBL01000004">
        <property type="protein sequence ID" value="PJN10696.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN10696">
        <property type="protein sequence ID" value="PJN10696"/>
        <property type="gene ID" value="CG723_15970"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000175">
        <property type="term" value="F:3'-5'-exoribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06135">
        <property type="entry name" value="Orn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00045">
        <property type="entry name" value="Oligoribonuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013520">
        <property type="entry name" value="Exonuclease_RNaseT/DNA_pol3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022894">
        <property type="entry name" value="Oligoribonuclease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11046">
        <property type="entry name" value="PTHR11046"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00929">
        <property type="entry name" value="RNase_T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00479">
        <property type="entry name" value="EXOIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0540">Nuclease</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Exonuclease" evidence="2">
        <location>
            <begin position="4"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN10696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="200" mass="22116" checksum="402EFC5C19379342" modified="2018-04-25" version="1">MNDRMVWIDCEMTGLSLANDALIEVAALVTDSELNVLGDGVDIVIRPPAEALETMPEVVRQMHTASGLLDELAGGTTLADAEEQVLAYVREHVKEPGKAPLCGNSVGTDRGFLLRDMPTLEDYLHYRIVDVSSVKELARRWYPRAYFNSPDKNGNHRALADIRDSIVELRYYREAVFVPQPGPDSDTAKKIAAKHALPAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JV16</accession>
    <name>A0A2M9JV16_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Acyl-CoA dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CG723_16045</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CB01635</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000004">
        <property type="protein sequence ID" value="PJN10709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN10709">
        <property type="protein sequence ID" value="PJN10709"/>
        <property type="gene ID" value="CG723_16045"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003995">
        <property type="term" value="F:acyl-CoA dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006089">
        <property type="entry name" value="Acyl-CoA_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="SSF47203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="SSF56645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00072">
        <property type="entry name" value="ACYL_COA_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00073">
        <property type="entry name" value="ACYL_COA_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0274">FAD</keyword>
    <keyword evidence="3 5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA_dh_N" evidence="8">
        <location>
            <begin position="7"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_M" evidence="7">
        <location>
            <begin position="122"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_1" evidence="6">
        <location>
            <begin position="234"/>
            <end position="382"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PJN10709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="386" mass="41858" checksum="34656CAE1E4EA32E" modified="2018-04-25" version="1">MDHRLSSEHEELRRTVEEFAHDVVAPKIGDFYERHEFPYEIVREMGRMGLFGLPFPEEYGGMGGDYLALGIALEELARVDSSVAITLEAGVSLGAMPLHLFGTEDQKAEWLPRLCSGEILGAFGLTEPDGGSDAGATRTTARVDEATGEWVINGTKCFITNSGTDITGLVTVTAVTGHSPEGKPQISSIIVPSGTPGFTVAAPYSKVGWNASDTRELHFDDVRVPAANLLGEQGRGFAQFLRILDEGRIAIAALATGLAQGCVDESVKYAKERHAFGRNIGSYQAIQFKIADMEMKAHTSRLAWRDAASRLVSGEPFKKEAALAKLYSSTIAVDNAREATQVHGGYGFMNEYPVARMWRDSKILEIGEGTSEVQRMLIARELGLTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JVP6</accession>
    <name>A0A2M9JVP6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ABC transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CG723_17275</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000004">
        <property type="protein sequence ID" value="PJN10966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN10966">
        <property type="protein sequence ID" value="PJN10966"/>
        <property type="gene ID" value="CG723_17275"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="12"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="229"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="44"/>
            <end position="51"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PJN10966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="260" mass="27385" checksum="F89AEFA88CE86ABC" modified="2018-04-25" version="1">MDASVKAGEPVIALRSVTAELGSRPVLRGIDLTVRRGEVVALLGANGSGKSTAVRTVIGQVPVSGGEVEIFGTPRRRFRDWARVGYVPQRTTAAGGVPATVTEVVSSGRLSRARFGLLRKADREAVRRALDLVGMADRAKDSVDALSGGQHQRVLIARALASEPELLIMDEPMAGVDLASQEILAQTLRAQVAAGASVLLVLHELGPLEPLIDRAIVLRDGCVLHDGPPPEAVGQHALPGHDHVHPHTSDLTPVRTGLLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JVU4</accession>
    <name>A0A2M9JVU4_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 6">GTPase Era</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">era</name>
        <name evidence="12" type="ORF">CG723_17155</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">CB01635</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
            <topology evidence="6">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6 8 9">Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Era GTPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000004">
        <property type="protein sequence ID" value="PJN10962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN10962">
        <property type="protein sequence ID" value="PJN10962"/>
        <property type="gene ID" value="CG723_17155"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070181">
        <property type="term" value="F:small ribosomal subunit rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042274">
        <property type="term" value="P:ribosomal small subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04163">
        <property type="entry name" value="Era"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00367">
        <property type="entry name" value="GTPase_Era"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030388">
        <property type="entry name" value="G_ERA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005662">
        <property type="entry name" value="GTP-bd_Era"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015946">
        <property type="entry name" value="KH_dom-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004044">
        <property type="entry name" value="KH_dom_type_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009019">
        <property type="entry name" value="KH_sf_prok-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42698">
        <property type="entry name" value="PTHR42698"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07650">
        <property type="entry name" value="KH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00326">
        <property type="entry name" value="GTP1OBG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54814">
        <property type="entry name" value="SSF54814"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00436">
        <property type="entry name" value="era"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51713">
        <property type="entry name" value="G_ERA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50823">
        <property type="entry name" value="KH_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 6 8" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 6 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="4 6 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="Era-type G" evidence="11">
        <location>
            <begin position="17"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="domain" description="KH type-2" evidence="10">
        <location>
            <begin position="221"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="region of interest" description="G1" evidence="8">
        <location>
            <begin position="25"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="G2" evidence="8">
        <location>
            <begin position="51"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="G3" evidence="8">
        <location>
            <begin position="72"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="G4" evidence="8">
        <location>
            <begin position="135"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="G5" evidence="8">
        <location>
            <begin position="169"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="25"/>
            <end position="32"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="72"/>
            <end position="76"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="135"/>
            <end position="138"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007921"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00020484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PJN10962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="317" mass="34743" checksum="271BF3E051E5D47C" modified="2018-04-25" version="1">MSVRTQSSEPSGEASHRAGFACFVGRPNAGKSTLTNALVGKKVAITADQPQTTRHTVRGIVHRPDAQLILVDTPGLHKPRTLLGQRLNDVVRTTWAEVDVIGFCLPANEKLGPGDRFIAKELASIKKTPKVAIVTKTDLVDSKQLAEQLIAIDQLGKELGFEWAEIVPVSAVGDKQVGLLADLLVPLLPEGPALYPEGDLTDEPEQVMVAELIREAALEGVRDELPHSIAVVVEEMLPREDRPADRPLLDIHAFVYIERPSQKGIIIGPKGKRLKDVGIKSRKQIEALLGTPVFLDLHVKVAKDWQRDPRQLRKLGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JW06</accession>
    <name>A0A2M9JW06_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_08915</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN11083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN11083">
        <property type="protein sequence ID" value="PJN11083"/>
        <property type="gene ID" value="CG723_08915"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="73"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN11083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="152" mass="16200" checksum="DA243BAA680D14A1" modified="2018-04-25" version="1">MRLQAGYWTVKPWFNGLSRIGSSYLAHIGATLVTPHIEALQTPWTRRSVPDVWDIPVQLKAGLVALELRAADSEPADTPAQPAHVPHGSAARGAPRGNPCSTEVQHTAAALPVPQALTRHRQGAEGSFCLLCTPEFDRVTVQVMACGGGFTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JWQ7</accession>
    <name>A0A2M9JWQ7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">GntR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CG723_10220</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN11299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN11299">
        <property type="protein sequence ID" value="PJN11299"/>
        <property type="gene ID" value="CG723_10220"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07377">
        <property type="entry name" value="WHTH_GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.530">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011711">
        <property type="entry name" value="GntR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008920">
        <property type="entry name" value="TF_FadR/GntR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07729">
        <property type="entry name" value="FCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
        <property type="entry name" value="GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00035">
        <property type="entry name" value="HTHGNTR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00895">
        <property type="entry name" value="FCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00345">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48008">
        <property type="entry name" value="SSF48008"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50949">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH gntR-type" evidence="4">
        <location>
            <begin position="9"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PJN11299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="236" mass="25547" checksum="95991D3546DAE0AB" modified="2018-04-25" version="1">MEQTAPQKGTVTQRAIEQIKAMIGEGLLEPGQRLPTERDLATQLGISRSSMREAIRALTVLGALEARHGSGIYVTQLNAGDLLETFGVVADLSRGARLVELMEVRRVLESTATALAAARITPEQLAEVELHLAAMAATDDPEEILSHDLAFHRVIATAAGNDTMAAILEGLSSRTFRARVWRGYQEEGAFERTGREHARIHRALVARDPEAARAAAAAHVGEVEAWMRSQLDAEPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JWT8</accession>
    <name>A0A2M9JWT8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CG723_10570</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN11361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN11361">
        <property type="protein sequence ID" value="PJN11361"/>
        <property type="gene ID" value="CG723_10570"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PJN11361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="655" mass="73043" checksum="12988A2AF6EA888C" modified="2018-04-25" version="1">MTSRYVLRLQVDPADDPTQAGDRLLALARAARAEEICVFLFGLEFNDGHESLDGVAHWLAATRPWRARLRAEGIAVSLNPGHTVGHSDWARSLKPGQTWQTMTDQHGTAAAVQVCPLDPGWRAYFARTLRLYAAEDVDTVWIEDDIRLHNHRPLDWGGCFCPLHLAEFARRTGIETTRDELVAACTAPGDPHPWRERWLDFWDSTQRELLTSWREILGDRLGLMSSRTDSHAAEGRDWQSWLDLPTVHRPHFWGYSDGAGPELPRAIQQLDMQRTVQPEGLRSFPEIECWPYGHWNKSFRQTGAQMSLAHVLGSDGLAISLYDFLGNHPDDEPRRASFLAEWRDTFDWLSETFPKTLRTVGVGLPWSERTGRRTRTEREGWQSLVVPHGSWAGLLGAAGHAVTARGGASVNALSGEATWSFEDAELREWLGQGLLLDSVAARILFERGYGPLIGVTGALPSPEGHAREICTDPEFSLRPGCAISLDTESYDRSTVVAFDPAPDARVASVVRDQLDRERGSGLLLYENALGGRVAVTPWPAHTPGMTLMNAQREAQLGAVLDWLDRGAHARATGHPWLVTQALTDGTRWRVVVWNASPDEADGFRLRLPQGMPEPRSVVQVTARGERLTAAWRDGRPLLSRPLGQWEYVVLSSKHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JWX2</accession>
    <name>A0A2M9JWX2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CG723_10755</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN11393.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN11393">
        <property type="protein sequence ID" value="PJN11393"/>
        <property type="gene ID" value="CG723_10755"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019756">
        <property type="entry name" value="Pept_S26A_signal_pept_1_Ser-AS"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00501">
        <property type="entry name" value="SPASE_I_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PJN11393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="64" mass="6586" checksum="E6969EFAD369DEF4" modified="2018-04-25" version="1">MSLSISVVLLLLILAVVFLRNGAMKISHAMVCVLLGFLLAGTSMAPTLHNGLTATAGIVSSLHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-09-29" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JX12</accession>
    <name>A0A2M9JX12_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">FAD-containing monooxygenase EthA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CG723_10790</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CB01635</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FAD-binding monooxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN11399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN11399">
        <property type="protein sequence ID" value="PJN11399"/>
        <property type="gene ID" value="CG723_10790"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004499">
        <property type="term" value="F:N,N-dimethylaniline monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020946">
        <property type="entry name" value="Flavin_mOase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00743">
        <property type="entry name" value="FMO-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="497"/>
            <end position="521"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PJN11399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="521" mass="57153" checksum="A5A90B6E99057DAA" modified="2018-04-25" version="1">MTHTADSSTAGSGAPAEHIDVVIVGAGLSGVGAAYRLRTECPERSYAIIEARQSMGGTWDLFRYPGVRSDSDMFTLGYPFKPWRDRKVLADGGSILSYIKETAAEFGIDRRIRYGTKVLAADWSTEAARWTLTLERTDEDGHRALSTVTCDFLYSCAGYYDYDKGHTPEFEGADSFSGTVVHPQFWPEGLDYAGKRVVVIGSGATAVTLVPAMAQSAAHVTMLQRSPTWISSLPSRDRLADGIRAALPAGVAHRVVRGKNILFTIGVYQFCRRSPKVARRVLTGLNKRIVKDDRLVDEHLTPSYDPWDQRLCAVPDADLFKVLNSGDADIVTDHIDRFVPEGIRLKSGRVVEADIIVSATGLKLLAFGGIAPRVDGEPVALNRQFVWRGAMMTGVPNFAVCIGYTNASWTLRADLTSRLVCKVLNHMRRHDYAAVEPRPTGALNERPLLDLASGYVKRSIDAFPRQGDRSPWKVRQNYVLDAASTMRTNLHRTLAPTPASTVRAARGRMGREPVEAATPGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JX46</accession>
    <name>A0A2M9JX46_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">4-hydroxythreonine-4-phosphate dehydrogenase PdxA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">pdxA</name>
        <name evidence="3" type="ORF">CG723_11195</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN11464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN11464">
        <property type="protein sequence ID" value="PJN11464"/>
        <property type="gene ID" value="CG723_11195"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005255">
        <property type="entry name" value="PdxA_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30004">
        <property type="entry name" value="PTHR30004"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04166">
        <property type="entry name" value="PdxA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00557">
        <property type="entry name" value="pdxA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN11464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="337" mass="34921" checksum="86061153C121B95B" modified="2018-04-25" version="1">MSTPLPLIAVTMGDGAGVGPEVVIVALLDDAVLTRCRPVVIGDAQRLREAARILGLGCEIAAVDHPRDAEFTPGRVNVVDLGLLPADLPWGKLSPIAGDAAYAYIARAAELAVAGDVHAICTAPLNKEALYAAGHIYPGHTELLAHLTGTEEVSMMLSTEKVKVIHVTTHIGLIDAVNRIEPGLVERTVRRGHEAMVRAGTPNPVIGVCGINPHAGENGLFGYGEEGEKIVPALEKLRAEGVDARGPLPADTAFFLAARGDYDLIVAMYHDQGHGPVKVLGIEAGVNLTVGLPVIRTSVDHGTAFDIAGTGAAEAGSMVEALRQAAEMATAPVAPAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-05-25" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JX63</accession>
    <name>A0A2M9JX63_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_11265</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN11475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN11475">
        <property type="protein sequence ID" value="PJN11475"/>
        <property type="gene ID" value="CG723_11265"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ADH_zinc_N" evidence="1">
        <location>
            <begin position="182"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="domain" description="GFO_IDH_MocA" evidence="2">
        <location>
            <begin position="410"/>
            <end position="530"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN11475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="734" mass="77843" checksum="35E8B7AF9179ABCF" modified="2018-04-25" version="1">MKQVVQNYKSGELAVLDVPVPGCKPGGVLVRTAYSLISTGTELMKVSEAGMSMLGKARSRPDQVAKVMQSVATNGVPATYRKVMGKLDSYTPLGYSLCGVVEQVGPGIDDVKVGDLVACAGNEHALHAELNWVPKNLYAPVPDGLAPRHAAFGTVGSIAMQGVRRGEPQLGDVALVIGLGLIGQLVVQLLAASGVRVVGVDPDPVRCDLAERLGAAACGDPESAAVEAAVAELTDGHGVDQVYLAAGGGSNQPVELAARLCRDRGRVVDIGKCRLDLPWNAYYEKELDVRFSRSYGPGRYDPEYELEGRDYPIGYVRWTERRNLACFLDLLARGSVDVEPLVSHIAGFDDAVETYQRLKDGDLKAVAVLFRYSEQAEEEGELAAPTVSVPEVRRSGGTSTPARSAKAPVRLAFVGAGNYATSMLLPHLAQRDGVELSTVVTTTALSAANAKRKFGFAEATTDLDAVLGDKSIDAVFVVTRHSSHAELTRRALLAGKTVFVEKPLALTEDELAGVLAAVEESGNDRLQVGFNRRFAPLLQEARKRFGARTGPASLRYLVNAGRLGHGSWYLQQGTEGSRFTGEGGHFIDTASWLLDADPVSVYAVATSGNEDLQVVLSYPDGSTATISYVTTGAAGFPKETLDLVADGKVLRLDDFVRASLYSDGRAGRKRWVSSRLPKARDKGQSAELAAFIKAVRTGGPMPVPLESLVATTTATLAVQAGLVGGAPVTLARAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JXD3</accession>
    <name>A0A2M9JXD3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_11675</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN11551.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN11551">
        <property type="protein sequence ID" value="PJN11551"/>
        <property type="gene ID" value="CG723_11675"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001845">
        <property type="entry name" value="HTH_ArsR_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01022">
        <property type="entry name" value="HTH_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00778">
        <property type="entry name" value="HTHARSR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00418">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50987">
        <property type="entry name" value="HTH_ARSR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH arsR-type" evidence="1">
        <location>
            <begin position="1"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN11551.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="112" mass="12672" checksum="16E43797A4C87012" modified="2018-04-25" version="1">MPAPAVWTALADPHRRAIVALLLERPRPVGEIVEACGLSQPSTSKHLRVLREAGLVDVEQEAQRRVYRLRPGPVAELDAWLEPYRRLWNDRLDALGRRLDAHAPEDDEPAKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JXF3</accession>
    <name>A0A2M9JXF3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_11465</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN11512.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN11512">
        <property type="protein sequence ID" value="PJN11512"/>
        <property type="gene ID" value="CG723_11465"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014799574" evidence="1">
        <location>
            <begin position="29"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN11512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="96" mass="10084" checksum="21686387B2703E06" modified="2018-04-25" version="1">MIRTRFRLLLPAALLLASVPLLGGTAQAGGTCFATHEDAPIYAGNNPWTDIVGYLDPGVPVNGTRQGADELWRVSRTDNGAPLGFMRAADLTCDGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JXK1</accession>
    <name>A0A2M9JXK1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">HAD family hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CG723_11715</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN11558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN11558">
        <property type="protein sequence ID" value="PJN11558"/>
        <property type="gene ID" value="CG723_11715"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041492">
        <property type="entry name" value="HAD_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023198">
        <property type="entry name" value="PGP-like_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022468">
        <property type="entry name" value="PhnX-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13419">
        <property type="entry name" value="HAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03351">
        <property type="entry name" value="PhnX-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PJN11558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="229" mass="24313" checksum="CA4A55F855DA796A" modified="2018-04-25" version="1">MIELAVFDMAGTTIEEHGAVYEALRHAVESTGVTVDAQDLQTWMGTDKREAIDALVRLGGGTPDAELVERQYGVFRLFLKQRYAEVPPQPIAQADKALAELRARGIKVALTTGFSDDVALPLLASLGWSTGEGGNLDAVVTADEVVRGRPAPYMIHRAMEKTGVVDVRKVLVAGDTAVDLQAGHHAGAGVVVGVLTGQLPRTELELHPHTYVLDSVAEVPGLAEAMAAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-05-25" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JXM7</accession>
    <name>A0A2M9JXM7_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ornithine aminotransferase</fullName>
            <ecNumber evidence="3">2.6.1.13</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Ornithine--oxo-acid aminotransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">rocD</name>
        <name evidence="7" type="ORF">CG723_12110</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CB01635</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-proline biosynthesis; L-glutamate 5-semialdehyde from L-ornithine: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.13" evidence="3"/>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN11621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN11621">
        <property type="protein sequence ID" value="PJN11621"/>
        <property type="gene ID" value="CG723_12110"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00098">
        <property type="reaction ID" value="UER00358"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050155">
        <property type="term" value="F:ornithine(lysine) transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004587">
        <property type="term" value="F:ornithine-oxo-acid transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055129">
        <property type="term" value="P:L-proline biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00610">
        <property type="entry name" value="OAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005814">
        <property type="entry name" value="Aminotrans_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010164">
        <property type="entry name" value="Orn_aminotrans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11986:SF18">
        <property type="entry name" value="PTHR11986:SF18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00202">
        <property type="entry name" value="Aminotran_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000521">
        <property type="entry name" value="Transaminase_4ab_Lys_Orn"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01885">
        <property type="entry name" value="Orn_aminotrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00600">
        <property type="entry name" value="AA_TRANSFER_CLASS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00030587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PJN11621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="407" mass="42688" checksum="17300B0710C59244" modified="2018-04-25" version="1">MTVAPVQAARSSAELISAETPVLAHNYHPLPVVVARAEGTWVEDVEGRRYLDLLAGYSALNFGHRHPALIEAAHRQLDQLTLTSRAFHNDRLAGFAEGLAELTGLDMVLPMNTGAEAVESAVKVARKWAYEVKGVPADRATIVVADGNFHGRTTTIVSFSTDESARAGFGPFTPGFRVVPYNDLSALEAAVDETTAAVLLEPIQGEAGVVIPDDGYLTGVRDLTRRAGCLFIADEIQSGLGRTGRTLAVDHEAVRPDMLLLGKALGGGIVPVSAVVAGRDVLGVLRPGEHGSTFGGNPLSAAVGSAVVDLLATGEFQRRAADLGEVLRAGLEALTGKGVNAFRARGLWAGVDIDPAIGTGRRISELLLDEGVLVKDTHGSTIRLAPPLTITREELESALAALGRVLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JY13</accession>
    <name>A0A2M9JY13_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Glucarate dehydratase</fullName>
            <ecNumber evidence="6">4.2.1.40</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">gudD</name>
        <name evidence="6" type="ORF">CG723_12965</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CB01635</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the mandelate racemase/muconate lactonizing enzyme family. GlucD subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.40" evidence="6"/>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN11760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN11760">
        <property type="protein sequence ID" value="PJN11760"/>
        <property type="gene ID" value="CG723_12965"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008872">
        <property type="term" value="F:glucarate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03323">
        <property type="entry name" value="D-glucarate_dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036849">
        <property type="entry name" value="Enolase-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029017">
        <property type="entry name" value="Enolase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029065">
        <property type="entry name" value="Enolase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034598">
        <property type="entry name" value="GlucD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013342">
        <property type="entry name" value="Mandelate_racemase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034593">
        <property type="entry name" value="Mandelate_racemase_DgoD-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48080">
        <property type="entry name" value="PTHR48080"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13378">
        <property type="entry name" value="MR_MLE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00005">
        <property type="entry name" value="glucarate_dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00922">
        <property type="entry name" value="MR_MLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51604">
        <property type="entry name" value="SSF51604"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54826">
        <property type="entry name" value="SSF54826"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MR_MLE" evidence="5">
        <location>
            <begin position="184"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="3">
        <location>
            <begin position="234"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="3">
        <location>
            <begin position="338"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="2">
        <location>
            <position position="206"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="2">
        <location>
            <position position="338"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="31"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="102"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="149"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="204"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="234"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="265"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3 4">
        <location>
            <position position="288"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="367"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="421"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009938"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR634598-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR634598-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR634598-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PJN11760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="445" mass="48594" checksum="4D2CC8B3DAB505A1" modified="2018-04-25" version="1">MTLSKQPTVTAFAVYPVAGRDCMELNLSGAHGPYFTRNVVVLQDSEGRTGLGEVPGGEKITQTLRDAESLVVGAKVGDYKRVLGEIGARFADRDSGGRGAQTFDLRTTVHAVTAVESAMLDLLGQHLEVPVAALLGDGQQRDSVRVLGYLFYVGDPGRTDLEYVREPDVAVDWHRVRHEEALTPEAIVRQAEAAYDRYGFRDFKLKGGVLEGAEEVKAVQALKDRFPEARITLDPNGAWSLREAIELCTPLSGTLAYAEDPCGAEGGYSGREILAEFRRATGLPTATNMIATDWRQLTHALALQSVSIPLADPHFWTMQGSVRVAQLCNAMGLTWGCHSNNHFDISLAMVTHCGAAAPGEYNALDTHWIWQEGLERLTTAPPRIVDGEIAVPDAPGLGVQLDMDRLLAAHDLYRTKALGARDDAIGMRYLVPDWQFDSKRPCLVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JYU5</accession>
    <name>A0A2M9JYU5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Polyisoprenoid-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_14620</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN12036.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN12036">
        <property type="protein sequence ID" value="PJN12036"/>
        <property type="gene ID" value="CG723_14620"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.128.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007372">
        <property type="entry name" value="Lipid/polyisoprenoid-bd_YceI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036761">
        <property type="entry name" value="TTHA0802/YceI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04264">
        <property type="entry name" value="YceI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00867">
        <property type="entry name" value="YceI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101874">
        <property type="entry name" value="SSF101874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YceI" evidence="2">
        <location>
            <begin position="43"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN12036.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="218" mass="24073" checksum="CDCB4957EBCA1CAB" modified="2018-04-25" version="1">MGIFSRRQSTTIEPTPAAGPRTPFPDAAAGATLDPALRALTGQWTIDRPHSRIGFSVRHAMVTTVRGAFADYDSTLYFDGARPSQSRADITIRVASVDTGVEQRDAHLIGTDFFDARRHPEMTFRSTSTTHEGKETFRMTGDLTIRGVTRPVELQLDYLGSVLDPFGYERAGFDATTTIDRTQWGLVYNQRLEAGGTMVSEKVRLQFDISAIRSTPIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-05-25" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JYU6</accession>
    <name>A0A2M9JYU6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">LacI family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CG723_14725</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN12052.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN12052">
        <property type="protein sequence ID" value="PJN12052"/>
        <property type="gene ID" value="CG723_14725"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01392">
        <property type="entry name" value="HTH_LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000843">
        <property type="entry name" value="HTH_LacI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046335">
        <property type="entry name" value="LacI/GalR-like_sensor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00356">
        <property type="entry name" value="LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13377">
        <property type="entry name" value="Peripla_BP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00354">
        <property type="entry name" value="HTH_LACI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50932">
        <property type="entry name" value="HTH_LACI_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH lacI-type" evidence="4">
        <location>
            <begin position="10"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PJN12052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="341" mass="36491" checksum="A073D87E528CDA6F" modified="2018-04-25" version="1">MPEQTTGSRPTLEAVAAYAGVSRATASRVVNGGAGVRAPLVDKVRRAVEELGYVPNHAARTLVTRRNGAVAVIIAEPELRIFSDPFFEQQVRGISRELTEHDAQLVLLWVEGPGDHDRIARYLGGGHVDGALAFSLHNDDELPALIGRTGIPAVFGGRPAAGSGLNVPFVDCDNRGGAREAVRHLVSLGRRHIAHIAGPRDQMSALNRIDGYHDVLLKADPALLCQGDFAEESGARAMAELLDRRPDVDGVFVSNDLMASGALRTLRERGVQVPEDVAVVGFDDMASVVRTTEPALTTVRQDIEGMGRLMVKLLMQRLDNADGEAPASVITPTTLVRRASA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JZ77</accession>
    <name>A0A2M9JZ77_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GNAT family N-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_11940</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN12170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN12170">
        <property type="protein sequence ID" value="PJN12170"/>
        <property type="gene ID" value="CG723_11940"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13302">
        <property type="entry name" value="Acetyltransf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="8"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN12170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="165" mass="17482" checksum="CAD50F75B9D73DA9" modified="2018-04-25" version="1">MVIATGRIELLPLQAEFADEMAVVLGDPALHAFIGGAPLTSPELRERYGRLIAGSPDPAVSWCNWVVRVREEGSLAGTVQATVGPGDDGLEAEIAWVVGVPWQGRGLATEAARGLVDWLGQRPVRTVVAHIHPDHAASAAVAKACGLAPTDRMHDGEIRWQLTLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JZF0</accession>
    <name>A0A2M9JZF0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_04155</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000002">
        <property type="protein sequence ID" value="PJN12263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN12263">
        <property type="protein sequence ID" value="PJN12263"/>
        <property type="gene ID" value="CG723_04155"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014942144" evidence="1">
        <location>
            <begin position="27"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN12263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="173" mass="16357" checksum="3B4783A91C0698B4" modified="2018-04-25" version="1">MRTSRLLTAAALAAAAAALTAAPSYAGKGGSGGLEVYPANATAGATVTVNTTACGASRAAAGDASAVGAGTFMLAPGSQAKDAVGRFQVPPSAPPGTYEIVAKCSGGGQVTGDLTVALASSSDQALPKGHVKTGVGGALGTDPVKTAAGVAALAVAAAGGTWLLHRRARGEGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JZG1</accession>
    <name>A0A2M9JZG1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Short-chain dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_04100</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000002">
        <property type="protein sequence ID" value="PJN12254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN12254">
        <property type="protein sequence ID" value="PJN12254"/>
        <property type="gene ID" value="CG723_04100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN12254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="304" mass="32447" checksum="E9FB8BF7C3ACA8E8" modified="2018-04-25" version="1">MTGWNASDIPDQSGRTAVVTGANSGIGYITARELARKGAHVVLACRSEARGTAALDRLRSEVPGAQAEFEQLDLGDLSSVRKFAGARGSGERLDLLINNAGVMALPLGRTADGFETQFGVNHLGHFALTGLLLPRLLDTPGARVVSVSSMFHVLSDIDIADLNSERRYRRWIAYGRSKTANLLFIHELARKLAARGSDVVAASAHPGYASTNLATQGVRMEGRKAVERVVELGNRVIAQPAEAGALPTLYAATEPGVRPDSFTGPSLMMWRGAPAKSWRAGRTLDDVAGERLWAASEQLTGVTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JZH9</accession>
    <name>A0A2M9JZH9_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Cell shape-determining protein MreB</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">mreB</name>
        <name evidence="3" type="ORF">CG723_04275</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Forms membrane-associated dynamic filaments that are essential for cell shape determination. Acts by regulating cell wall synthesis and cell elongation, and thus cell shape. A feedback loop between cell geometry and MreB localization may maintain elongated cell shape by targeting cell wall growth to regions of negative cell wall curvature.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Forms polymers.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <text evidence="2">Membrane-associated.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the FtsA/MreB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000002">
        <property type="protein sequence ID" value="PJN12281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN12281">
        <property type="protein sequence ID" value="PJN12281"/>
        <property type="gene ID" value="CG723_04275"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000902">
        <property type="term" value="P:cell morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd10225">
        <property type="entry name" value="MreB_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02207">
        <property type="entry name" value="MreB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004753">
        <property type="entry name" value="MreB"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01652">
        <property type="entry name" value="SHAPEPROTEIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0133">Cell shape</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="165"/>
            <end position="167"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="294"/>
            <end position="297"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN12281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="345" mass="36318" checksum="BC5860742BCE46C8" modified="2018-04-25" version="1">MTVSLEQLRRCHLAVDLGAARTRVYVKGAGLVVDEPSAAAVNTRTGALIAVGELAEKMTGRTPDYIRVMRPVSGGTVIDIDMAQRMLRHLIGEKLRRALRRKPRLRAAACTPHDADPLAQRAAVETLVGLGARRVELVDTLIAAAVGCDLPVERPEGTMIIVCGAATTQIAVLSLGSIVTAQRIPVGGDAIDHAVVQHLRQHHELMLPSQSVRPLQIALSGNGLTPYGPESTEIHGRDVATGLARSVVVDTAAVRHAIHTPLTAVLDGIGKVLRDCPPDLVADLADRGIMMVGGSALLPGFDQMLRDATGVPVHIAERPDICAVLGLGAMLEGKVQPLTLTPVAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JZL2</accession>
    <name>A0A2M9JZL2_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Deoxyguanosinetriphosphate triphosphohydrolase-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CG723_04195</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CB01635</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the dGTPase family. Type 2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000002">
        <property type="protein sequence ID" value="PJN12270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN12270">
        <property type="protein sequence ID" value="PJN12270"/>
        <property type="gene ID" value="CG723_04195"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008832">
        <property type="term" value="F:dGTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006203">
        <property type="term" value="P:dGTP catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00077">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01212">
        <property type="entry name" value="dGTPase_type2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006261">
        <property type="entry name" value="dNTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020779">
        <property type="entry name" value="dNTPase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023023">
        <property type="entry name" value="dNTPase_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006674">
        <property type="entry name" value="HD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026875">
        <property type="entry name" value="PHydrolase_assoc_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11373:SF32">
        <property type="entry name" value="PTHR11373:SF32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01966">
        <property type="entry name" value="HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13286">
        <property type="entry name" value="HD_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00471">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01353">
        <property type="entry name" value="dGTP_triPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51831">
        <property type="entry name" value="HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HD" evidence="3">
        <location>
            <begin position="102"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="36"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PJN12270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="463" mass="50930" checksum="93B60ED67C157EB1" modified="2018-04-25" version="1">MEGTHETPAAKSVPAIPTAPSHPIDQSGYDAAAAERWAPEPDKRPGRTAFQRDRARVLHSSALRRLAGKTQVVTPGTIPQALDSARAGGTPIRAWDASPRTRLTHSLECAQVGRELGAALGCDPDLVETACLSHDMGHPPFGHNGEQALNEVAQDCGGFEGNAQSLRLLTRIEPKRFVQSADTDELVSVGLNLTRAALDAATKYPWPRGGHPTDPASPKFGVYEDDRPVFDWIRKESPERRTCFEAQVMDWSDDVAYSVHDLEDGLHAGHLDPNMLHAEPERRDIYAVAIGRYVPADTDPEELAAALDRLLDQEWWPHGYDGTAVAQARLKDATSQLIGRFCLAAEGATRTRYGSGRLTRYEAELVVPREARYECAVLKAVADRYVMQRPQQERLRADQRIVVAELAEALTLRAPDGLDPQFRALFDTAGDDRSRKRVIVDQISSLTDASARELHARLTGPRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JZT6</accession>
    <name>A0A2M9JZT6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Glycosyl transferase family 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CG723_04985</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000002">
        <property type="protein sequence ID" value="PJN12403.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN12403">
        <property type="protein sequence ID" value="PJN12403"/>
        <property type="gene ID" value="CG723_04985"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044249">
        <property type="term" value="P:cellular biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901576">
        <property type="term" value="P:organic substance biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028098">
        <property type="entry name" value="Glyco_trans_4-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13439">
        <property type="entry name" value="Glyco_transf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_4-like_N" evidence="5">
        <location>
            <begin position="36"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="domain" description="Glycos_transf_1" evidence="4">
        <location>
            <begin position="257"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="439"/>
            <end position="464"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF13439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PJN12403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="464" mass="49809" checksum="2E1CA4D779BABAB5" modified="2018-04-25" version="1">MTAEAMEAGPRARSSADGDRPLRIALLTYKGNPFCGGQGVYVRHLSRELARLGHQVEVIGSQPYPVLDDGEDLSGLRLTELPSLDLYRSPDPFRTPKRDEYRDWVDALEVGTMWIGGFPEPLTFSLRARRHLRARRGEFDIVHDNQTLGYGLLGGPAALGAPLVTTIHHPITVDRQLEIDAAPDWKRRASVRRWYAFTRMQKRVARRLPSVLTVSGTSRQEIVDHLGVRQDRIRVVHIGADTDLFSPDPSVAEVPGRIVTTSSADVPLKGLVFLIEALAKVRTENPAAHLVVVGKRAEDGPVAAAIEKYGLEGAVSFVKGITDAELVDLVRSAEVACVPSLYEGFSLPAAEAMATGTPLVATTGGAIPEVAGPDGETCLAVPTGDAGALAAALGRLLDDPRLRARLGAAGRERVLGNFTWARAALGTAELYRESIARSAGRTTGAAATTPLERAGSDRESRATC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JZT7</accession>
    <name>A0A2M9JZT7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">TetR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_04980</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000002">
        <property type="protein sequence ID" value="PJN12402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN12402">
        <property type="protein sequence ID" value="PJN12402"/>
        <property type="gene ID" value="CG723_04980"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041642">
        <property type="entry name" value="KstR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17925">
        <property type="entry name" value="TetR_C_20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="20"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="43"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN12402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="206" mass="23005" checksum="9A76D590D93C83A1" modified="2018-04-25" version="1">MTAEAKTAHPASPPLTERQEARRRRILHASAQLASRGGFDAVQMREVAESSQVALGTLYRYFPSKVHLLVATMQDQLQHMHATVRKRPPSSDLPSERVAETLMRAFRALQREPHLADAMVRALTFADRSVSPEVDQVSRQTTAIILDAMELDDPTPQQLSAVRVIEHTWHSALITWLSGRASIAQVKIDIETVCRLIDLTTPDAKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K0J2</accession>
    <name>A0A2M9K0J2_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Histidinol-phosphate aminotransferase</fullName>
            <ecNumber evidence="3">2.6.1.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Imidazole acetol-phosphate transaminase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">hisC</name>
        <name evidence="6" type="ORF">CG723_06405</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CB01635</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>2-oxoglutarate + L-histidinol phosphate = 3-(imidazol-4-yl)-2-oxopropyl phosphate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:23744"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57766"/>
            <dbReference type="ChEBI" id="CHEBI:57980"/>
            <dbReference type="EC" id="2.6.1.9"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 3">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 7/9.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.9" evidence="3"/>
    <dbReference type="EMBL" id="NNBL01000002">
        <property type="protein sequence ID" value="PJN12653.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN12653">
        <property type="protein sequence ID" value="PJN12653"/>
        <property type="gene ID" value="CG723_06405"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00031">
        <property type="reaction ID" value="UER00012"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004400">
        <property type="term" value="F:histidinol-phosphate transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01023">
        <property type="entry name" value="HisC_aminotrans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001917">
        <property type="entry name" value="Aminotrans_II_pyridoxalP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005861">
        <property type="entry name" value="HisP_aminotrans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01141">
        <property type="entry name" value="hisC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00599">
        <property type="entry name" value="AA_TRANSFER_CLASS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="2 3" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="3" id="KW-0368">Histidine biosynthesis</keyword>
    <keyword evidence="3" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotran_1_2" evidence="5">
        <location>
            <begin position="34"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="3">
        <location>
            <position position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PJN12653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="374" mass="40715" checksum="4D684F4388602D24" modified="2018-04-25" version="1">MEGSRPVTGIDDLPVRDELRGKSPYGAPQLDVPVRLNTNENPYPLPEPLVERIAERVRESARDLNRYPDRDAVQLRTELAGYLTRTGGHHVGIENVWAANGSNEVIQQLLQTFGGPGRSAIGFEPSYSMHGLIARGTGTGWISGPRSADFTIDVEASVQAIAENRPDVVFITTPNNPTGSAVPPETVLALYEAAQAAKPSMVVVDEAYIEFSHGNSLLPLLEGRPNLVISRTMSKAFGAAGLRLGYMAAAPAVVDAVQLVRLPYHLSAVTQATALAALEHTDTLLKYVEQLKDERDRLVTELRATGYEVTDSDANFVQFGRFDDAHAVWQQILDRGVLVRDNGVPGWLRVSTGTPDENDAFLDAVRAIKKERNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K0P8</accession>
    <name>A0A2M9K0P8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_06755</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000002">
        <property type="protein sequence ID" value="PJN12711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN12711">
        <property type="protein sequence ID" value="PJN12711"/>
        <property type="gene ID" value="CG723_06755"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004155">
        <property type="entry name" value="PBS_lyase_HEAT"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00567">
        <property type="entry name" value="EZ_HEAT"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="SSF48371"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="SSF48403"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="40"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="73"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="106"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN12711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="492" mass="51346" checksum="5D117308EC69D0CB" modified="2018-04-25" version="1">MDEEQKAGASGLFDAVYGGDEDAVVRALRAGAAADEPDDEGRTALYLASVSDEPGIVRLLLSAGADPDRLSSGTDLPLCGAACGGHTEVVRALLAAGARVDLREEFGFTAMAWALQRGHERVVRALLDGGADPQLPAPGGGLPLVAAARRGSTGCVRALVEHGAQGRTEALAEALAWCGVDVAAVLRTGLERPESEAVTQRFVEDGGVTVVVELLDEEGRPRSGNDMQTGHAAIATLLEADLGVVTPAAELAERALRRGDPDDDDWTEAASVLQARGDEETYRWAAAWCASDEELRRAFGADVLGQLGPRGRYTARSLPVLCALARAARDTAGLRSAVVALGHLGDPAALPEILLQAEHPEPRVRRAVALALTGLMPAGHDEAVAALVALTRDADGDVRNWAAAALAAAPADTAEVRDALAALLDDPVPDAAAEAARGLALRHDLRAVEALARILACQAPGGYAHDTARDAIRHVPDARVRARLEWTVPRCR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K1D8</accession>
    <name>A0A2M9K1D8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CG723_08045</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000002">
        <property type="protein sequence ID" value="PJN12945.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN12945">
        <property type="protein sequence ID" value="PJN12945"/>
        <property type="gene ID" value="CG723_08045"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PJN12945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="262" mass="27169" checksum="FC2BDDD9E7037DBF" modified="2018-04-25" version="1">MLSEPRSGRLASWGNSLLAGFVAPDDAALAIVGEDAVHRVEGLPGESAPVGLTLALGRLRTLGATGLRVALPAPGHPLGLSGPPEFNARALDAEEAVVCQGAALGLVPEVYEAGPADDVHVDVLWHCLPVREAPPADVPSLGEAERELAEALRDATAVLSRLDVAGSGPVAEAAVDAYRARAERGREVLAPGYPPRAVRVLELAQRVGLLISVASESGHGGAMSASEMAARSEALRPVERTARRAQVAAYNAFVEERERGGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K251</accession>
    <name>A0A2M9K251_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Carbohydrate ABC transporter, N-acetylglucosamine/diacetylchitobiose-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">ngcE</name>
        <name evidence="3" type="ORF">CG723_01060</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000001">
        <property type="protein sequence ID" value="PJN13209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN13209">
        <property type="protein sequence ID" value="PJN13209"/>
        <property type="gene ID" value="CG723_01060"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022386">
        <property type="entry name" value="Chitin_NgcE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006059">
        <property type="entry name" value="SBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13416">
        <property type="entry name" value="SBP_bac_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03851">
        <property type="entry name" value="chitin_NgcE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014760780" evidence="2">
        <location>
            <begin position="41"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="41"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN13209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="482" mass="51991" checksum="67182D7355D86105" modified="2018-04-25" version="1">MGSTSAQNNGEGFGRRDLIKRSAALGLVAVPTMSFLSACASSDSGSGDKAEKGKTSKKNPLGVNETAPLAVTIFDGGFGTKYATDANAEYKKAFPKAKIDFHKTQKIQSELQPKFNGGTPPDLIDNSGAEQMDMGVLVGKKQLTDLTPLLDAPSIDDPSKKVRDTLRPGIVEMGQFDGDPVWIMYYAYTVYGVWYSQKALDGLDAQYPETWDDMLALCAKAKKKGIAGWTYAGKYPYYLPFSLYPFIAKIGGREVLDKIDNLEPNAWKDPAVKSAFEAYYELYKKGYILKGTPGIDHIQSQTAWAKGKALFIPNGSWVENESAKVIPADFGLSVGAPTGLDSSDKMPFGTIWASGGEPFIVPAKANNVEGGMEQLRLMLSEASSKNFTSSVKSLTALNGGTDGIELTPGLKSGVAALDKAGENVVNPRLQDWYVKLQKEQIGVSCLGEMMAGRLTPAEAIKKIQGFADAAAKDQSIKHYKHQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K2W6</accession>
    <name>A0A2M9K2W6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_02515</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000001">
        <property type="protein sequence ID" value="PJN13461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN13461">
        <property type="protein sequence ID" value="PJN13461"/>
        <property type="gene ID" value="CG723_02515"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="171"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="174"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN13461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="452" mass="48550" checksum="A5B0552DB5724822" modified="2018-04-25" version="1">MEVEQLPDQVREFAVYLRNLLARLDQDAGWCGIFWQRDPDGMRACLTGAEVPPWDVMEALLQDLGVGGGSYEAAADAGAGAEAVRARALHRASLTAFDARPGGRDLLGDRLDVMLREQRYAAERQVELAQLLHTAATREQAEAMRLDLAWARDDHERATARCAELHRRIADLDRQPPPPPPLPVPQQRPQSAPPDPPGRSKPPKERKRRPRGSARFAGMLDEAEAPVAGATESTVDSTPPAAQGPLRDPAASPRGARFAGAVEGQEAAPPAPQRLDGEARAAIAACVGTLLRLRAEGRGGEAHGALVEAAHWPAARFPLLAAELNRAGLGADWATLLWETASLPADLLVAAADALTAAGRTVDAQQILRQGVARPATEIGASVLRLTGEGRHRETRALLDAYIRVRTPEEAARSVHDDPGRLVPLLVEAARGVSDERYWDVVHALRVAGFPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JEN6</accession>
    <name>A0A2M9JEN6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">IS3 family transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_45285</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000052">
        <property type="protein sequence ID" value="PJN05351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN05351">
        <property type="protein sequence ID" value="PJN05351"/>
        <property type="gene ID" value="CG723_45285"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025948">
        <property type="entry name" value="HTH-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002514">
        <property type="entry name" value="Transposase_8"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13276">
        <property type="entry name" value="HTH_21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01527">
        <property type="entry name" value="HTH_Tnp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="2">
        <location>
            <begin position="221"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="58"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN05351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="393" mass="43474" checksum="EFD94F69CBB0E588" modified="2018-04-25" version="1">MGTSKYSPEFRADAVALYHSSPGGMYASVAKDLGVNHETLRTWVRDAGQAARPGAVEATAMEKLNRQLRARVKELELEREILRRAAKYFGGGDQLVSSRFQFVDDHRGAFGVKRLCRILAVSRSGFYRWLAGASARAGRARADAELAEHIDRIHQESDGTYGVPRVTAELKEAGRPVNHKRVERVMRKFHIVGLHLRRKVRTTIPEPSATPVPDLLQRDFAAQVPNTKYVGDITYLPIGNGQFLYLATVLDLCSKRLTGWSIADHMRTSLVTEALRAAARARGGDGLRGAIFHSDNGAQYVSKEFAQVCSELGVTRSRGTVGTSADNAAAKSLNASMKRETLQGRKRGNGAREARLAVFRWATRYNTRRRHSRLGQISPITYEQRSTTLATAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JET3</accession>
    <name>A0A2M9JET3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Acyl-CoA desaturase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_44855</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000049">
        <property type="protein sequence ID" value="PJN05401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN05401">
        <property type="protein sequence ID" value="PJN05401"/>
        <property type="gene ID" value="CG723_44855"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005804">
        <property type="entry name" value="FA_desaturase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012171">
        <property type="entry name" value="Fatty_acid_desaturase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19353">
        <property type="entry name" value="PTHR19353"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00487">
        <property type="entry name" value="FA_desaturase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FA_desaturase" evidence="1">
        <location>
            <begin position="67"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN05401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="372" mass="42833" checksum="83C121D6311BA762" modified="2018-04-25" version="1">MTAIDPTAHLSAEQIEELGRELDAIRDEVIAGRGEKDAAYIRKVISAQRKLELVSRGVLLFSIFPPAWLIGTAGLSVAKIMDNMEIGHNILHGQWDWMRDPKIHSTTWEWDHVSPSEQWKHSHNELHHTYTNVIGKDNDLGYGIMRVDEDQKWHPFYLGQPLWNFINACFFEYGIAAYDLELGKNLHKRRRNNPEFRARAKAVGRKIRKQVLKDYVIHPLLSGPSFLPTLAATFTANLVRNIWTHSVIMCGHFPEGVQVFERRSIKGETRGQWYLRQMMGSANISGSRAMHFMTGNLSHQIEHHLFPDLPSNRYAEVAVKVRALFEKYELEYVTGPLPKQVFSAWHKVFRLSLPNKKPKVKTPDREQELVAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-05-25" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JF34</accession>
    <name>A0A2M9JF34_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Aldo/keto reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_44500</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000047">
        <property type="protein sequence ID" value="PJN05506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN05506">
        <property type="protein sequence ID" value="PJN05506"/>
        <property type="gene ID" value="CG723_44500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NADP_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42686">
        <property type="entry name" value="PTHR42686"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="SSF51430"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldo_ket_red" evidence="1">
        <location>
            <begin position="49"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN05506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="376" mass="40371" checksum="CACC2D87294E6E76" modified="2018-04-25" version="1">MLSAAAAWLNPVRTVRPLKSGDTVPNTPRDIATGTSRVEIGEHGLRLPRIGLGTASLGNFLGAVTDEQAVDTIRHARDRGIRYVDTAPLYGHGLAEQRVGSALRDTPREDLVISSKVGRLLRADAPRDESQYADGQPFYTDVPATGPVWDFTYDGVRTSLAESLDRLDLDRVDILHLHDPDDHYEQASSTAYAALRDLRAKGTVKAIGAGMNRTPVLTRLVENCDLDVVLLAGRYTLLDQGAMADLLPACREHGTKVVVGGVFNSGILVDPSPQARYDYVPAAPAVIAKAARIQAVCDRYDVPLAAAALQFPLAHPQIASVLVGARSLAELDMDLSLLEVVIPDALWHDLRASGLLPEDVPVPVGPPATGLERTAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-06-02" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JF40</accession>
    <name>A0A2M9JF40_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">DNA-binding response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CG723_44540</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000048">
        <property type="protein sequence ID" value="PJN05432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN05432">
        <property type="protein sequence ID" value="PJN05432"/>
        <property type="gene ID" value="CG723_44540"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00383">
        <property type="entry name" value="trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="2"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="domain" description="OmpR/PhoB-type" evidence="5">
        <location>
            <begin position="124"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="3">
        <location>
            <begin position="124"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PJN05432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="226" mass="24829" checksum="8C782111B92CCB4D" modified="2018-04-25" version="1">MRILVVEDEVDLAHTLHTGLTAEGYSVDLAHDGRQGLWMARTGEYALVVLDLMLPGLNGYKVCAQLRREGNATPILVLTAKDGEWDQAEALDTGADDYLAKPFSYVVLVARLRALVRRAATVAPPVLAVGDLSLDVAGRVCRRAGARVELTPREFAVLELLARRAGQAVSKTDLLYHAWPDEALDPNLVEARVSALRKKVDTAFGRRSLQTVRGTGYRLVDDRERD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JFB7</accession>
    <name>A0A2M9JFB7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_44670</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000048">
        <property type="protein sequence ID" value="PJN05447.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN05447">
        <property type="protein sequence ID" value="PJN05447"/>
        <property type="gene ID" value="CG723_44670"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025959">
        <property type="entry name" value="Winged_HTH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13592">
        <property type="entry name" value="HTH_33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH_33" evidence="2">
        <location>
            <begin position="96"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="159"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN05447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="179" mass="20358" checksum="F0CAB2E44561405F" modified="2018-04-25" version="1">MRYPEGGGLTPERRAFREKIRLQAGERFAAGEKTAVIAKDLRVSVRSVERWRRAWREGGTEALRSAGPANVPTVTDGQFAVLEEELGKGPAAHGFEDERWTLARVQTVIRRRLRVSLSVATVWRMLKRHGWSWQAPARRALERDEHAVELWKKEVWPRVKASRRPMAPGSSSRTKPGSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JFT8</accession>
    <name>A0A2M9JFT8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CG723_43195</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000042">
        <property type="protein sequence ID" value="PJN05738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN05738">
        <property type="protein sequence ID" value="PJN05738"/>
        <property type="gene ID" value="CG723_43195"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007155">
        <property type="term" value="P:cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005528">
        <property type="entry name" value="ChpA-H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019931">
        <property type="entry name" value="LPXTG_anchor"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03777">
        <property type="entry name" value="ChpA-C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51884">
        <property type="entry name" value="CHAPLIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50847">
        <property type="entry name" value="GRAM_POS_ANCHORING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0034">Amyloid</keyword>
    <keyword evidence="3" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="1" id="KW-0134">Cell wall</keyword>
    <keyword evidence="5" id="KW-0572">Peptidoglycan-anchor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0964">Secreted</keyword>
    <keyword evidence="2 8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015006579" evidence="8">
        <location>
            <begin position="29"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="domain" description="Chaplin" evidence="10">
        <location>
            <begin position="39"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="domain" description="Chaplin" evidence="10">
        <location>
            <begin position="106"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="domain" description="GRAM_POS_ANCHORING" evidence="9">
        <location>
            <begin position="197"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="79"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="143"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="153"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="180"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PJN05738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="231" mass="22130" checksum="62D27083A31BA86E" modified="2018-04-25" version="1">MRQVTRKGLITVAAATGVLAVSGGYAHADSGAEGGSSGSPGVLSGNTIQLPVDVPVNACGNTVNVVGLLNPAAGNDCANTSKPGGGHPGGSHHGGGATAEGGTSDSPGVGSGNHVQVPVHVPVNACGNGVSVIGLLNPAGGNDCANSPGGDKPTTPPTKPPTQPEPNTPAPPKPVTPSTPNHPGTQTVTQPEGSEQLAETGSSMPLGTVLPAGAGALLAGALLYRRARAGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JFW7</accession>
    <name>A0A2M9JFW7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_42805</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000041">
        <property type="protein sequence ID" value="PJN05768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN05768">
        <property type="protein sequence ID" value="PJN05768"/>
        <property type="gene ID" value="CG723_42805"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="27"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="88"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN05768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="275" mass="28273" checksum="99E72D32D1B312AF" modified="2018-04-25" version="1">MPRMLDVSDDVRAEIGDAEADRLLAGENAPGTYDCTSCRTPGDSEQERTSTVLFIGDETAVLAFAHSTCLPSQVVQVSEEQLQGAVRSITGDGGAPAAASPVPSPAAQPIPGQAAPQPQQAVLGVTSGLVLIAGELHPALVVEPTGPIARPGATSGMDEFLTLLVEQGFTPTAQVGQVPPVLHGWSVLLAMGQLHAVLQPGTAGLGQVAWWQAHQPLHVTDSWRAAANKTNSVLVFAAPSGTIGRQPREDLLRDALDKAAANGLLVGATMPLAGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JG55</accession>
    <name>A0A2M9JG55_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_42310</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000039">
        <property type="protein sequence ID" value="PJN05871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN05871">
        <property type="protein sequence ID" value="PJN05871"/>
        <property type="gene ID" value="CG723_42310"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="73"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="123"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="157"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="182"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="204"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="232"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="271"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="296"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="321"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="353"/>
            <end position="377"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN05871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="508" mass="54958" checksum="045B04A7AD6D4E1E" modified="2018-04-25" version="1">MRAASNAALRAAAPLVLLLVVALLVAVAIRLPWAGDLGIHAATVERLRHDLLDPGNPLVDEKTPSPYYSPWTVFLGVVADVTGLGTFTVLRIAALISLTLLVTGVWRFTGTFTEASASRSRRTAVTALVLLCLLLLWGTSLFNWSGFLGLNSLALTLSYPSTFALGLSFHLWALLRGALARGSGLPGFLGLGLLWSVILLSHQFTGVVTSFGALAMVAGARPWPARAVWARLVAGLALGAVVLAAWPYYSFFDLFHAQGLEEIHQALYRNLPGRYWLLLAGVFALALRWRRDRRDPLVIFFALGVLMFAAGWVSGHYSWGRVLPAAVIPAQVAAGLEVCGAERRAGRRTVRTAFAAVLGAVLLAGAWTQSGVLGYVVPRDVLPKPLADRYKPPWRGYHWMTPWVKYGDVVLATDFPARQIPAYGPYTVAPGYPDFFLPDEAARTSAVGTYFAPGTERAARLDVLRRYGVRWIVSHRDDAGLAATDPALHKVTTGPGGQTLYEVVGDRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JGV1</accession>
    <name>A0A2M9JGV1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_40910</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000035">
        <property type="protein sequence ID" value="PJN06108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN06108">
        <property type="protein sequence ID" value="PJN06108"/>
        <property type="gene ID" value="CG723_40910"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032722">
        <property type="entry name" value="Deaminase_XOO_2897"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14440">
        <property type="entry name" value="XOO_2897-deam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="224"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="276"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="493"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="228"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="276"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="493"/>
            <end position="519"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN06108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="525" mass="57596" checksum="A3954D295B088128" modified="2018-04-25" version="1">MGKTLPDDLVAVMDLVGVSWPNIDEDEVRGSAKDYRHLADGIRDIITEGNRACSHIVGGKSKGKTVQAIDRRWGKLTTKDLSTFIKALDDLADALDDCAGFIEGCKIVCITELSATAATATAGVIGMFFTAGLSGLLSAGAIAACRIALHEAINYATGEITSIVTDKIEAKILDKIEDLFTDQLDAHDDNDLGHYAVGTGDMAQDLAIEFDDFDKASGDYDKTKRNFDKKKNAHKTGGGKRRSSVKKDSRFHKLATVMDKAEDAVDKKADETVHVLEKHGGKIDASKKEHKKSDEKTRDDVNRCKVDDDDTPMYLLNADGTVERLNPDGSTDPVKKTDNSGIRDLMTEPGQKPGEAGRVWRPRKGQKGPSYPVSPSKDKAVVTSRKVAPGSTDLSRATQIARYHNQDWGGGNYAAGRYQDPSGKEMVLVTNSEGPHSERTLGYPILKAEKQDNLTEVYTEREPCQGRPSWCDKWTAKYFGSDLEVTHSAKYLNSEEPKIRDVEHEKYRSQLEKDQKAHGVSGGFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-06-02" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JGZ1</accession>
    <name>A0A2M9JGZ1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_40935</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000035">
        <property type="protein sequence ID" value="PJN06112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN06112">
        <property type="protein sequence ID" value="PJN06112"/>
        <property type="gene ID" value="CG723_40935"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="101"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="112"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN06112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="171" mass="19681" checksum="6CDEA77BBABE31BE" modified="2018-04-25" version="1">MGRFRDWRTGTRYPDEGVEPLARSHVEAALFALNGPDKPYRVRTALAEEKADVVAEWHMLEPGWGSGMGRRQVERTFKFRMRLDGGAHEVRVCADVRETTRAGDPPTRVVARRHGKGPRTRVKSWRGSYKKGPDGRRQRVDDFRFDSNDLRDPLQEVVLTSGWTWRGTHKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JH43</accession>
    <name>A0A2M9JH43_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Serine hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_40565</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000034">
        <property type="protein sequence ID" value="PJN06172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN06172">
        <property type="protein sequence ID" value="PJN06172"/>
        <property type="gene ID" value="CG723_40565"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008800">
        <property type="term" value="F:beta-lactamase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030655">
        <property type="term" value="P:beta-lactam antibiotic catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046677">
        <property type="term" value="P:response to antibiotic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045155">
        <property type="entry name" value="Beta-lactam_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000871">
        <property type="entry name" value="Beta-lactam_class-A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35333">
        <property type="entry name" value="PTHR35333"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13354">
        <property type="entry name" value="Beta-lactamase2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Beta-lactamase2" evidence="1">
        <location>
            <begin position="29"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN06172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="299" mass="31876" checksum="1095391C74402646" modified="2018-04-25" version="1">MNAIADEIAAVFAEAGAQGFLHAREIGVTDGPEVAVGADAPVVLASVFKIPVAVAYVREVAAGRLDETERTRVTARYRVGGIGTAGCVDDVEMSWRDLALFMLTMSDNAATDVVFHRVGQDAVDRVLTDLGLSRTRIRGCCEDHFASLLSDLGAGEGDDAEAVLAAATPEQLWKLAVLDPARTTSSTPREITRLLDAIWTDRAADPGACEKVRAIMGRQIWPHRISSGLDTGVQVAAKTGTLPAIRNEAGVLTYPDGRQYAVAVFTRADSLEDRRPAVDTSIGRAARLAVDHLRHGMTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JHI4</accession>
    <name>A0A2M9JHI4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_39445</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000031">
        <property type="protein sequence ID" value="PJN06341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN06341">
        <property type="protein sequence ID" value="PJN06341"/>
        <property type="gene ID" value="CG723_39445"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000674">
        <property type="entry name" value="Ald_Oxase/Xan_DH_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036856">
        <property type="entry name" value="Ald_Oxase/Xan_DH_a/b_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016208">
        <property type="entry name" value="Ald_Oxase/xanthine_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008274">
        <property type="entry name" value="AldOxase/xan_DH_Mopterin-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037165">
        <property type="entry name" value="AldOxase/xan_DH_Mopterin-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11908">
        <property type="entry name" value="PTHR11908"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01315">
        <property type="entry name" value="Ald_Xan_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02738">
        <property type="entry name" value="Ald_Xan_dh_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01008">
        <property type="entry name" value="Ald_Xan_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54665">
        <property type="entry name" value="SSF54665"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56003">
        <property type="entry name" value="SSF56003"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ald_Xan_dh_C" evidence="1">
        <location>
            <begin position="28"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM01008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN06341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="712" mass="74840" checksum="B9CA62E7E06433CF" modified="2018-04-25" version="1">MTTTTTATPVTGTAGASYTRVEGLEKVTGAARYAGDVPAAELAHGWLVLSTVARGRIRSIESDPVRGMPGVLAVLHHGNAPRVDGNYVGMLGRPDPIVEVFQHDRVPFVGWPVALVVAETTEQAREAAEALVVRYDEEPHDVAFSAGHAGIYTPDGDGMLAEKGDLAAELAASVHVVDAEYTTPEEHHSSMEPHAAMARWDGGRLEIVDSNQGSMWVAQELAKLFSLDPASVRVRSEHIGGAFGSKGVRVHQILAVMAATVLDRPVRVVMTRRQMFSLVGYRSPTAQRVRLGADADGRLRALDHQAHSLTSTVHEFVEASAGFGRPMYAADAHRSVNRVVRLDVPTPTFMRAPGEAPGSFALESALDELAEQCGMDPIALRARNEPDVGPVSGLPFGSRNLLACFDEGARRFGWADRDPRPGVRREGRWLLGTGTAAATFPVIVAPSTAAVTAEADGTFTVRIGASDVGTGARTALTLLAAEALGVAGERVHVRIGDSDFGPAAISGGSMGTRSWGWAVTAAGRDLREQLALGGDIPPQGITVRSDTSAAVGSLTQKERHSFGAQFAEVAVDVTTGEVRVRRMLGVFAAGRIVNPLTARSQFIGGMIWGLSMALHEEAIRDQATGGHVGADLAGYHFAANADVPLIEADWVDDPDADDPVGIKGIGEIGIVGAAAAVANAVWHATGVRHRHLPIRPDRVLSAGAPAAGDGDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JHV9</accession>
    <name>A0A2M9JHV9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_39375</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000030">
        <property type="protein sequence ID" value="PJN06465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN06465">
        <property type="protein sequence ID" value="PJN06465"/>
        <property type="gene ID" value="CG723_39375"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="26"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN06465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="68" mass="6934" checksum="998D508BFE6B4A2B" modified="2018-04-25" version="1">MFLAGAVATLATVAPLFLGTEPLPSVFYWVCTLMGLGFLIAAAGVIRSATAQRRQVAAPSPPSTPSAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-09-29" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JHZ9</accession>
    <name>A0A2M9JHZ9_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">SSD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CG723_38670</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CB01635</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000029">
        <property type="protein sequence ID" value="PJN06472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN06472">
        <property type="protein sequence ID" value="PJN06472"/>
        <property type="gene ID" value="CG723_38670"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004869">
        <property type="entry name" value="MMPL_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000731">
        <property type="entry name" value="SSD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03176">
        <property type="entry name" value="MMPL"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50156">
        <property type="entry name" value="SSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015006582" description="SSD domain-containing protein" evidence="7">
        <location>
            <begin position="31"/>
            <end position="757"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="180"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="204"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="230"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="278"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="306"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="370"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="525"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="556"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="596"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="638"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="663"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="domain" description="SSD" evidence="8">
        <location>
            <begin position="180"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PJN06472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="757" mass="79319" checksum="0198883AC49CF0A4" modified="2018-04-25" version="1">MAALARWCARHRLVVVLLWLLALGATSAAAAVAGSSYSNDYEAPGTESGRATQLLDDGFPGLGGDSDTVVWHTDGSMVRAADVKERMTRTLDRIEHLPGISAVTGPYEQQGTSQISADGRTAYAMVTFDQQSGDVAKADAQRLVDTAKAAEKNAPDGLRVELGGSAVALTESAQGHVAEIIGVVVAAAVLLLAFGSLAASALPIATALVSVGTAASGIVLLGHVMTVADFAPMLGMLVGLGVGIDYALFIVTRHRRGLKQGLPVNEAAERAVATTGRAVVFAGATVCIALLGMLILRLSFLNGVAIAASLTVLLTVVASVTLLPALLSFIGMRALSRRQRRRLAEHGPEPERPAGFAARWAVFVERHPRLLGGLALGVIAVLSVPTFFLHLGTSDQGNNASSSTTRQAYDLLADGFGPGVNGPLTLVTPIDGAGDQVALSRLESLIDSAEGVSSVTPATYNGSGTAAFLTVVPKSAPQSQRTSELVDRLRSDVIPAAEKGTSLDVQLGGVTASYDDFADVIVGKLPLFVGVVIGLGCVLLLLAFRSIGIPLKAAAMNVAAVASAFGVVVAIFQWGWGSEMLGLGRAGPIEPFLPVIMVSVLFGLSMDYQVFLVSRMYEEWLETRDNRRAVRVGLAETSRVINSAAVIMISVFLAFVLSGDRVIAMFGIALAAAVALDAFVLRTLLVPALMHMLGGANWWLPKWLDRRLPRISIEPPECGEAHASMPGQRPTEDDALLDVLVKAEAEELKRDVHDLPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JIU1</accession>
    <name>A0A2M9JIU1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">NADH-quinone oxidoreductase subunit M</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CG723_37480</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CB01635</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 3">Membrane</location>
            <topology evidence="1 3">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the complex I subunit 4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000026">
        <property type="protein sequence ID" value="PJN06773.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN06773">
        <property type="protein sequence ID" value="PJN06773"/>
        <property type="gene ID" value="CG723_37480"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042773">
        <property type="term" value="P:ATP synthesis coupled electron transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010227">
        <property type="entry name" value="NADH_Q_OxRdtase_chainM/4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003918">
        <property type="entry name" value="NADH_UbQ_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001750">
        <property type="entry name" value="ND/Mrp_mem"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43507">
        <property type="entry name" value="PTHR43507"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00361">
        <property type="entry name" value="Proton_antipo_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01437">
        <property type="entry name" value="NUOXDRDTASE4"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01972">
        <property type="entry name" value="NDH_I_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="3 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014864066" evidence="5">
        <location>
            <begin position="22"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="31"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="78"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="123"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="186"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="234"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="297"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="326"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="357"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="395"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="430"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="472"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="domain" description="Proton_antipo_M" evidence="6">
        <location>
            <begin position="139"/>
            <end position="443"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PJN06773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="523" mass="55785" checksum="B6698B82BE43AA78" modified="2018-04-25" version="1">MSFPLLTATAVLPAVGAIATAAVPAARRTAAKWLALLVSLATLVLAAVVLVRFEPGGARYQLTESHSWIKDFGVRYELGVDGIAVALIALTALLIPFVILAGWHDADPQETGSSRWRPTQGFFALILGVEAMVVISFEATDVFLFYIFFEAMLIPMYFLIGGFGDRAHAGSDENAAAQRSYAAVKFLLYNLVGGLIMLAAVIGLYVVAGNFSLQEIAAARADGSLHMATSTERWLFLGFFFAFAVKAPLWPLHTWLPNAMGEATAPVAVLITAVVDKVGTFAMLRFCLQLFPEASKWATPVILVLALISIVYGALLAVGQRDIKRLVAYASISHFGFIVLGIFAMTSQGQSGATLYMVNHGISTAALMLVAGFLISRRGSRLIADYGGVQKVAPVLAGTFLIGGLATLSLPGLAPFVSEFLVLVGTFSRYPVIGIIATFGIVLAALYTLVLYQRTMTGPVKPEVSSLPDLRVRELAVVVPLIAALIFLGVYPKPVTDLVNPAVKQTLSDVHKKDPKPAVEAAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JIX4</accession>
    <name>A0A2M9JIX4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Protein RarD</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">rarD</name>
        <name evidence="11" type="ORF">CG723_37580</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CB01635</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the EamA transporter family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000026">
        <property type="protein sequence ID" value="PJN06819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN06819">
        <property type="protein sequence ID" value="PJN06819"/>
        <property type="gene ID" value="CG723_37580"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000620">
        <property type="entry name" value="EamA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004626">
        <property type="entry name" value="RarD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22911:SF114">
        <property type="entry name" value="PTHR22911:SF114"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00892">
        <property type="entry name" value="EamA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00688">
        <property type="entry name" value="rarD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="36"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="64"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="95"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="119"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="142"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="170"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="202"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="232"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="257"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="10">
        <location>
            <begin position="5"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="10">
        <location>
            <begin position="145"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="292"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="302"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PJN06819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="328" mass="35220" checksum="6938CCE6B14165FF" modified="2018-04-25" version="1">MLNGIAAYGMWGLVPLFWPLLKPAGAGEILAHRMVWSLAVVGIALLFVRRWAWAGELLRNPRRLALVTVAAAVITVNWGVYIWAVNAGHVVEASLGYFINPLVTIAMGVLLLGERLRPAQWAAVGVGLAAVLVLAFGYGQPPWISLCLAFSFATYGLVKKKVNLGGLESLAAETAIQFVPALAYLLWIGAQGESTFGNGAGHATLLAATGLVTAIPLVCFGAAAIRVPLSTLGLLQYLAPVFQFLLGILYFHEAMPAERWAGFALVWVALTLLTWDALRTARRGRIALAEQEARVTAPETVPESIPQPQTQTQPQTQPETDPRREPAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-09-29" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JJ49</accession>
    <name>A0A2M9JJ49_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Peptidase S15</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_37530</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000026">
        <property type="protein sequence ID" value="PJN06817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN06817">
        <property type="protein sequence ID" value="PJN06817"/>
        <property type="gene ID" value="CG723_37530"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008239">
        <property type="term" value="F:dipeptidyl-peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005674">
        <property type="entry name" value="CocE/Ser_esterase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000383">
        <property type="entry name" value="Xaa-Pro-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013736">
        <property type="entry name" value="Xaa-Pro_dipept_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02129">
        <property type="entry name" value="Peptidase_S15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08530">
        <property type="entry name" value="PepX_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00939">
        <property type="entry name" value="PepX_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="SSF49785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00976">
        <property type="entry name" value="NonD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PepX_C" evidence="1">
        <location>
            <begin position="291"/>
            <end position="514"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN06817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="666" mass="74156" checksum="E7114E123774C16B" modified="2018-04-25" version="1">MTIRTSFPYETTREDVRVPLPDGTTLFARIWRPVTDEPVPAILEYLPYRLSDWTAPRDWQRHPWYAGHGYASVRVDVRGHGNSEGLPGDEYDTTELADGVAVVNWLAEQPWCTGKVGMFGISWGGFNSLQIAALAPEPLKAVVTVCSTDDRYDNDVHYMGGSVLAVDMHAWAATMLAFVSRPPDPQFVGEGWRDMWLERLEAVDPFIHTWLGHQTRDAYWQHGSVCEDYTAVRAAVLAVGGWHDPYRDTVLRLVENLPDQQVRGIIGPWSHQYPDRGLPPGPAIGFLQETLRWWDHHLKGADNGVMAEPKLRSWISDSHPPATVYPTLPGHWVGDPSWPSPNVAPLAYALQGPPVIVKSPQQTGLDAGRFFPFGNDADLPPDQRDEDAKSACFEFEVPSDLQVLGRPQVTLRITSEAPRGQVAVRVCDVAPDGSSTLVTRGVLNFSSREGRDKAVAWSPGTTDEVSFELNGIGHTFPAGHRIRLAVSSAYWPWIWPQPGSEAGFTLDPAGSTLELPVRMVDAENGADIGFEPPEQSEPMGVVHPATLDEQRPERLCVRDVAKGEWRLEVDPRYGGTRVYPDGLEFTEDAVETYVIQEADPLSARTRSDWSIRLHRPELAWDVTIKTRSEIACDATDFITSNEVVCRDGGEVVFHRTWEQRIPRTAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-09-29" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JJ78</accession>
    <name>A0A2M9JJ78_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Peptigoglycan-binding protein LysM</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CG723_36760</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CB01635</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the transglycosylase family. Rpf subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000025">
        <property type="protein sequence ID" value="PJN06837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN06837">
        <property type="protein sequence ID" value="PJN06837"/>
        <property type="gene ID" value="CG723_36760"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00118">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13925">
        <property type="entry name" value="RPF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.350.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018392">
        <property type="entry name" value="LysM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036779">
        <property type="entry name" value="LysM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023346">
        <property type="entry name" value="Lysozyme-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010618">
        <property type="entry name" value="RPF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01476">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06737">
        <property type="entry name" value="Transglycosylas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00257">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53955">
        <property type="entry name" value="SSF53955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54106">
        <property type="entry name" value="SSF54106"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51782">
        <property type="entry name" value="LYSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014961455" evidence="3">
        <location>
            <begin position="41"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="domain" description="LysM" evidence="4">
        <location>
            <begin position="269"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="132"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="302"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="171"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="201"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="231"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010830"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PJN06837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="325" mass="32686" checksum="EB1B3D47D9CBC179" modified="2018-04-25" version="1">MLTGNGRHRRPRQAPALIVAAGVAGSAIAIPLLGATSASAASTATWDKLAECESGGSWSADPGNGYYGGLQFSQETWENYGGLDFAPRADQASRSQQIAVAEKVLADQGPRAWPVCSVTSGLTADAAAADVDPGAALPTPSAGDSGSDDAADGAAKGDASDEPSDSASSGAKDTSREKNHDKSGDTAGNTSDDSKSDKSGRDGSTSTPATPSPEASAGSDAATPPASGRHRGDAAADDTADSLRADDGSGRHASRGDESGRKQANQDEGAYTVRAGDNLWDIADTHDVDGGWAALYAENKKTVGADPDLILPGQSLDLGLESGEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JJ89</accession>
    <name>A0A2M9JJ89_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Lactate dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_36130</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000024">
        <property type="protein sequence ID" value="PJN06933.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN06933">
        <property type="protein sequence ID" value="PJN06933"/>
        <property type="gene ID" value="CG723_36130"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1530.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043144">
        <property type="entry name" value="Mal/L-sulf/L-lact_DH-like_ah"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043143">
        <property type="entry name" value="Mal/L-sulf/L-lact_DH-like_NADP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036111">
        <property type="entry name" value="Mal/L-sulfo/L-lacto_DH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003767">
        <property type="entry name" value="Malate/L-lactate_DH-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11091">
        <property type="entry name" value="PTHR11091"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02615">
        <property type="entry name" value="Ldh_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89733">
        <property type="entry name" value="SSF89733"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN06933.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="330" mass="34136" checksum="9BD354466658FBBB" modified="2018-04-25" version="1">MTTLTLPDARALVAAAMTAHGHSAESAETIADHLLDCELRGLSFGGLARALSIAERIRTTDVPPQPIRVVAETPVSATVDGGDQVGYLVGMHALQLAVEKARTQGIAVVGARNTWYTGMFSYYLEQAAKSGLAGMIAGSAPALVAPHGGTEARFGTNPIAFGFPATPAPVIWDIGTSAVMYGEATLKARLGEKLTPGQAYDAAGIPTLDPAAALEGAFGVWGGHKGSGLALVVQLLGMMTGAAADPPGISDCGFFVVLFDPGALTDPDDYRQRVTAFAESIRATRPVEAGSPVRVPFDGSVARRNETLRRGTIDVPEAVVAALREEATSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JJD9</accession>
    <name>A0A2M9JJD9_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5">Alpha-galactosidase</fullName>
            <ecNumber evidence="2 5">3.2.1.22</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CG723_36535</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CB01635</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 5">
            <text>Hydrolysis of terminal, non-reducing alpha-D-galactose residues in alpha-D-galactosides, including galactose oligosaccharides, galactomannans and galactolipids.</text>
            <dbReference type="EC" id="3.2.1.22"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the glycosyl hydrolase.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.22" evidence="2 5"/>
    <dbReference type="EMBL" id="NNBL01000024">
        <property type="protein sequence ID" value="PJN06991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN06991">
        <property type="protein sequence ID" value="PJN06991"/>
        <property type="gene ID" value="CG723_36535"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052692">
        <property type="term" value="F:raffinose alpha-galactosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016052">
        <property type="term" value="P:carbohydrate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14791">
        <property type="entry name" value="GH36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038417">
        <property type="entry name" value="Alpga-gal_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002252">
        <property type="entry name" value="Glyco_hydro_36"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031705">
        <property type="entry name" value="Glyco_hydro_36_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031704">
        <property type="entry name" value="Glyco_hydro_36_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16874">
        <property type="entry name" value="Glyco_hydro_36C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16875">
        <property type="entry name" value="Glyco_hydro_36N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005536">
        <property type="entry name" value="Agal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00743">
        <property type="entry name" value="GLHYDRLASE36"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glyco_hydro_36N" evidence="9">
        <location>
            <begin position="68"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_hydro_36C" evidence="8">
        <location>
            <begin position="633"/>
            <end position="710"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="7">
        <location>
            <begin position="349"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="7">
        <location>
            <begin position="459"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="6">
        <location>
            <position position="461"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="6">
        <location>
            <position position="531"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="182"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="426"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="509"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="531"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR005536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR005536-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR005536-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF16874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF16875"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PJN06991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="714" mass="78761" checksum="C6809544C0A2F34D" modified="2018-04-25" version="1">MSTTDRPLDRWVLRTATTVYAVTLGGDGEGDGPGAGIWPELSVWGPTGAEDGPAPLEWSRRTHFVTPADLAPAEYIPHGLRPFNGADLTASRPGGERGVWWRFTEARQENDAALDLTFDDDVLGLRVTVRYATVPGTDIIRRWSELTCTGDETLRLERIDSAAVNVPVSAQGTRVTYLTGQWSQEFSFTQTQLTRGTLEFGSTQGVPGHAYAPWLAVQDAAHPDRGADSPTYGIALEWAGNWHMAVDAEPGGAVRVRAGRVPHEGAVLLAPGETLVTPKLACAFSPDGLDGLSRVWHRYERHLAGDRLTRRRPVLYNSWEATEFDVRADHQLTLARRAADLGAELFVVDDGWFTGRHDDTGGLGDWHPDPALFPQGFDRFIDDVRALGLDFGLWVEPEAVSPASKLYAERPDWIYQLPHRTGRRVRNQLLLDLGREDVQDFVLGTLDRLLGRYDISYLKWDMNRPPTERGRPGPRSAQQLDLDAAHVAGYLRVLDHLRARHPHVTVEGCAGGGGRIDHSTLARTDVVWPSDNTAPLDRLRIQYGYLHAHAPHTMSSWVTDAQGLFDPRPRSLAFRFVSAMTGVLGIGADLGAWSEEQLASAARWIARYKDVRDVVHHGDTYVLGSPDEPTFGVESVAPDEARVVVAALSTGRLDGSPLVPGRPDRLRLKGVDAGARYRDETDGQEYGGAYLRHVGLPFCWSAEHDAELTVLRRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-09-29" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JJE7</accession>
    <name>A0A2M9JJE7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">SMI1/KNR4 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_36615</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000024">
        <property type="protein sequence ID" value="PJN07006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN07006">
        <property type="protein sequence ID" value="PJN07006"/>
        <property type="gene ID" value="CG723_36615"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018958">
        <property type="entry name" value="Knr4/Smi1-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037883">
        <property type="entry name" value="Knr4/Smi1-like_sf"/>
    </dbReference>
    <dbReference type="SMART" id="SM00860">
        <property type="entry name" value="SMI1_KNR4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160631">
        <property type="entry name" value="SSF160631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SMI1_KNR4" evidence="1">
        <location>
            <begin position="37"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN07006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="195" mass="21759" checksum="6AF936EAEF721BFA" modified="2018-04-25" version="1">MDPRIPRLRRKLAAIPFQPLRSHSFGEEQHEFRLGPKLAEARVAAFEAEHDIVLPDAYRQFLTHIGGSGAAPFYGLMPVERCSLLVMNPRGEPGTPRGFDATGPRAHGRDLFLHIIEMGCTDVCVLAVTGPLTGRVLIGNSDGFWGPNVSSATDFLEWYERWLNHMSAGRDNRALELTSPRLRAHPDRPRMAPKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JJF4</accession>
    <name>A0A2M9JJF4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CG723_36610</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000024">
        <property type="protein sequence ID" value="PJN07005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN07005">
        <property type="protein sequence ID" value="PJN07005"/>
        <property type="gene ID" value="CG723_36610"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PJN07005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="132" mass="14946" checksum="79C7EEBD34820EFF" modified="2018-04-25" version="1">MIPWNLLDLDRALRASWAADTCSPDDQADWQPGNPAWGHCDITALVINDIFSGDLIVGEVHLDGTEHGFHWWNRLPSGIELDLTREQFQLGQTVTAARVVARPPGPLPRRWEEYLLLRERVIKHLGPLPEPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JJJ4</accession>
    <name>A0A2M9JJJ4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">IS110 family transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_36245</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000024">
        <property type="protein sequence ID" value="PJN06947.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN06947">
        <property type="protein sequence ID" value="PJN06947"/>
        <property type="gene ID" value="CG723_36245"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003346">
        <property type="entry name" value="Transposase_20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002525">
        <property type="entry name" value="Transposase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01548">
        <property type="entry name" value="DEDD_Tnp_IS110"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02371">
        <property type="entry name" value="Transposase_20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DEDD_Tnp_IS110" evidence="1">
        <location>
            <begin position="5"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN06947.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="413" mass="45829" checksum="256EA6838E060ED3" modified="2018-04-25" version="1">MQVTCGIDWAEDHHDVAVVDSDARLLGKLRVSDDAAGFQDLLRLLAEHGDTPDDPIPIAIETSRGLMVACLRASGRQVFAINPMAVARYRDRHSVSRKKSDHQDAVVLANILRTDAELHRPLPGDTELVKAIAVLARAQQDAVWDRTRAHNRLSSHLREYYPAVLEAFADKREKLLAREARAILAIAPTQAKAAKLARSKLKAAVKQAGRQRRIDAETDRLLEVFRRTWLRQPTLVETAMGHQTLALLAQLEAACKACDELASATEELFLQHPDAEIITSFPGLAALTGARLLAEIGDDRTRFDTARDLKAYAGSAPVTRESGKSRRVSHRRIKNSRLAATGRHWAFAALTASIGAHDHYNRRRETGDRYYAALRNLFNRMLGQLHHCLTTRQRFNEAIAFAPPNPSPLTAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JJR7</accession>
    <name>A0A2M9JJR7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CG723_35835</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000023">
        <property type="protein sequence ID" value="PJN07103.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN07103">
        <property type="protein sequence ID" value="PJN07103"/>
        <property type="gene ID" value="CG723_35835"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PJN07103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="191" mass="20003" checksum="00F5E4A0842C758A" modified="2018-04-25" version="1">MVSIVPTVPLPRRPLDAGDPVREWYENALGWATAPGPEGLQLLTGLRFDVLELPAEAGRAVLRRLDPRCPVALQGETMRLLVAAGSAEELPGLLDWLEWGALPLDLTVAGAGGRIDAPAPPGVPDPQEAAVWVRPPEPGCDVEPTLPALTALSAVGGGGGAPGLVRLVETAATQCHRIRLRRGCTQPLAFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-09-29" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JJS8</accession>
    <name>A0A2M9JJS8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_35830</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000023">
        <property type="protein sequence ID" value="PJN07102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN07102">
        <property type="protein sequence ID" value="PJN07102"/>
        <property type="gene ID" value="CG723_35830"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.320.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036625">
        <property type="entry name" value="E3-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024412">
        <property type="entry name" value="Lsr2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042261">
        <property type="entry name" value="Lsr2_dimerization"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11774">
        <property type="entry name" value="Lsr2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="54"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN07102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="112" mass="11897" checksum="1A1A1DF2F354D65C" modified="2018-04-25" version="1">MAQKVQVLLVDDLDGGEADETVTFALDGKTYEIDLTTANADKLRGLLEPYLKGGRRTGGRSAGGRGKARAAVAGGSQDTAQIRAWAKENGYEVNDRGRVPASIREAYEKANG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-05-25" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JJY1</accession>
    <name>A0A2M9JJY1_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Urease subunit beta</fullName>
            <ecNumber evidence="2">3.5.1.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Urea amidohydrolase subunit beta</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2" type="primary">ureB</name>
        <name evidence="3" type="ORF">CG723_34775</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>2 H(+) + H2O + urea = CO2 + 2 NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:20557"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16199"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="EC" id="3.5.1.5"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Nitrogen metabolism; urea degradation; CO(2) and NH(3) from urea (urease route): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Heterotrimer of UreA (gamma), UreB (beta) and UreC (alpha) subunits. Three heterotrimers associate to form the active enzyme.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the urease beta subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.5" evidence="2"/>
    <dbReference type="EMBL" id="NNBL01000022">
        <property type="protein sequence ID" value="PJN07162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN07162">
        <property type="protein sequence ID" value="PJN07162"/>
        <property type="gene ID" value="CG723_34775"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00258">
        <property type="reaction ID" value="UER00370"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035550">
        <property type="term" value="C:urease complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009039">
        <property type="term" value="F:urease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043419">
        <property type="term" value="P:urea catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00407">
        <property type="entry name" value="Urease_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01954">
        <property type="entry name" value="Urease_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002019">
        <property type="entry name" value="Urease_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036461">
        <property type="entry name" value="Urease_betasu_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00699">
        <property type="entry name" value="Urease_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51278">
        <property type="entry name" value="SSF51278"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00192">
        <property type="entry name" value="urease_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN07162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="103" mass="10894" checksum="7D8A48A8D78D0E63" modified="2018-04-25" version="1">MIPGEILFADEPVVFNEGREVTRLTVLNAADRPVQVGSHYHFAEANPGLEFDRAAAHGLRLNVAAGTAVRFEPGIPVDVELVPLAGRRIVPGLRGQTGGALDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JK63</accession>
    <name>A0A2M9JK63_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">CPBP family intramembrane metalloprotease domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_35290</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000022">
        <property type="protein sequence ID" value="PJN07254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN07254">
        <property type="protein sequence ID" value="PJN07254"/>
        <property type="gene ID" value="CG723_35290"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071586">
        <property type="term" value="P:CAAX-box protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003675">
        <property type="entry name" value="Rce1-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02517">
        <property type="entry name" value="Rce1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="26"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="75"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="117"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="208"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="235"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN07254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="266" mass="28111" checksum="F00A64A9B8CFEF70" modified="2018-04-25" version="1">MQAEAGAVADSFPNERLSRRILRNETLLVLALSLGASGVSALISFVGSVTKPGGLKDQAATLNASAAPGRPWLDLAWQLFGIASALVPVALVAHLLLREGAGMRTIGFDRTRPLFDATRGAVIAAVIGSTGIAFYLAARGLGFNLTVVPEALPDVWWKYPVLVLSAIQNSVLEEVIVVGYLLRRLGQLGWTPGTAIVASSVLRGSYHLYQGIGGFFGNLAMGLVFAYLYRRWGRVGPLVVAHSLLDIGAFVGYALLAGKVGWLPTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JK94</accession>
    <name>A0A2M9JK94_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">CoA-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_35040</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000022">
        <property type="protein sequence ID" value="PJN07207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN07207">
        <property type="protein sequence ID" value="PJN07207"/>
        <property type="gene ID" value="CG723_35040"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003781">
        <property type="entry name" value="CoA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13380">
        <property type="entry name" value="CoA_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00881">
        <property type="entry name" value="CoA_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CoA_binding" evidence="1">
        <location>
            <begin position="12"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN07207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="135" mass="14626" checksum="B674B69425543CAA" modified="2018-04-25" version="1">MYGDQETVRRILTELGDTWAVVGLSSNRARAAYGVAEVLQRFGKRVVPVHPKAGTVHGEQGYASLDEIPFKVDVVDVFVNSHLAGQVADEARAIGAEAVWFQLGVIDEAAYDRTREAGLAMVMDTCPAIEIPRLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JKE3</accession>
    <name>A0A2M9JKE3_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 7">6,7-dimethyl-8-ribityllumazine synthase</fullName>
            <shortName evidence="7">DMRL synthase</shortName>
            <shortName evidence="7">LS</shortName>
            <shortName evidence="7">Lumazine synthase</shortName>
            <ecNumber evidence="4 7">2.5.1.78</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">ribH</name>
        <name evidence="8" type="ORF">CG723_34340</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CB01635</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>(2S)-2-hydroxy-3-oxobutyl phosphate + 5-amino-6-(D-ribitylamino)uracil = 6,7-dimethyl-8-(1-D-ribityl)lumazine + H(+) + 2 H2O + phosphate</text>
            <dbReference type="Rhea" id="RHEA:26152"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15934"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58201"/>
            <dbReference type="ChEBI" id="CHEBI:58830"/>
            <dbReference type="EC" id="2.5.1.78"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 7">Cofactor biosynthesis; riboflavin biosynthesis; riboflavin from 2-hydroxy-3-oxobutyl phosphate and 5-amino-6-(D-ribitylamino)uracil: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the DMRL synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.78" evidence="4 7"/>
    <dbReference type="EMBL" id="NNBL01000021">
        <property type="protein sequence ID" value="PJN07333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN07333">
        <property type="protein sequence ID" value="PJN07333"/>
        <property type="gene ID" value="CG723_34340"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00275">
        <property type="reaction ID" value="UER00404"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009349">
        <property type="term" value="C:riboflavin synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000906">
        <property type="term" value="F:6,7-dimethyl-8-ribityllumazine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009231">
        <property type="term" value="P:riboflavin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd09209">
        <property type="entry name" value="Lumazine_synthase-I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.960">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00178">
        <property type="entry name" value="Lumazine_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034964">
        <property type="entry name" value="LS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002180">
        <property type="entry name" value="LS/RS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036467">
        <property type="entry name" value="LS/RS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21058">
        <property type="entry name" value="PTHR21058"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00885">
        <property type="entry name" value="DMRL_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52121">
        <property type="entry name" value="SSF52121"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00114">
        <property type="entry name" value="lumazine-synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0686">Riboflavin biosynthesis</keyword>
    <keyword evidence="6 7" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="5-amino-6-(D-ribitylamino)uracil binding" evidence="7">
        <location>
            <begin position="58"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="5-amino-6-(D-ribitylamino)uracil binding" evidence="7">
        <location>
            <begin position="81"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="1-deoxy-L-glycero-tetrulose 4-phosphate binding" evidence="7">
        <location>
            <begin position="86"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="7">
        <location>
            <position position="89"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="26"/>
        </location>
        <ligand>
            <name>5-amino-6-(D-ribitylamino)uracil</name>
            <dbReference type="ChEBI" id="CHEBI:15934"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="114"/>
        </location>
        <ligand>
            <name>5-amino-6-(D-ribitylamino)uracil</name>
            <dbReference type="ChEBI" id="CHEBI:15934"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="128"/>
        </location>
        <ligand>
            <name>(2S)-2-hydroxy-3-oxobutyl phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58830"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PJN07333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="161" mass="16847" checksum="7C8DB38B7D515E17" modified="2018-04-25" version="1">MSGKGAPELSVRNCGDLRVAVIAAQWHEKVMDGLVDGALRALHELGIDEPTLLRVPGSFELPVVAKVLAGRGYDAIVALGVVIRGGTPHFEYVCQGVTMGLTQVTIDTGVPVGFGVLTCDTEEQALDRAGIEGSNEDKGHEAVTAAVATAATLRSVSEPWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JLE7</accession>
    <name>A0A2M9JLE7_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Threonine--tRNA ligase</fullName>
            <ecNumber evidence="10">6.1.1.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Threonyl-tRNA synthetase</fullName>
            <shortName evidence="10">ThrRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">thrS</name>
        <name evidence="13" type="ORF">CG723_31965</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">CB01635</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>ATP + L-threonine + tRNA(Thr) = AMP + diphosphate + H(+) + L-threonyl-tRNA(Thr)</text>
            <dbReference type="Rhea" id="RHEA:24624"/>
            <dbReference type="Rhea" id="RHEA-COMP:9670"/>
            <dbReference type="Rhea" id="RHEA-COMP:9704"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57926"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78534"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="10">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.3" evidence="10"/>
    <dbReference type="EMBL" id="NNBL01000018">
        <property type="protein sequence ID" value="PJN07695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN07695">
        <property type="protein sequence ID" value="PJN07695"/>
        <property type="gene ID" value="CG723_31965"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004829">
        <property type="term" value="F:threonine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006435">
        <property type="term" value="P:threonyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00771">
        <property type="entry name" value="ThrRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.800">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00184">
        <property type="entry name" value="Thr_tRNA_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002314">
        <property type="entry name" value="aa-tRNA-synt_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004154">
        <property type="entry name" value="Anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036621">
        <property type="entry name" value="Anticodon-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004095">
        <property type="entry name" value="TGS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002320">
        <property type="entry name" value="Thr-tRNA-ligase_IIa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018163">
        <property type="entry name" value="Thr/Ala-tRNA-synth_IIc_edit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033728">
        <property type="entry name" value="ThrRS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012947">
        <property type="entry name" value="tRNA_SAD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11451">
        <property type="entry name" value="PTHR11451"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03129">
        <property type="entry name" value="HGTP_anticodon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00587">
        <property type="entry name" value="tRNA-synt_2b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07973">
        <property type="entry name" value="tRNA_SAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01047">
        <property type="entry name" value="TRNASYNTHTHR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00863">
        <property type="entry name" value="tRNA_SAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55186">
        <property type="entry name" value="SSF55186"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00418">
        <property type="entry name" value="thrS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51880">
        <property type="entry name" value="TGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="6 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 10 13" id="KW-0436">Ligase</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8 10" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 10" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 10" id="KW-0820">tRNA-binding</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="TGS" evidence="12">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="domain" description="AA_TRNA_LIGASE_II" evidence="11">
        <location>
            <begin position="290"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="353"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="404"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="531"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PJN07695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="658" mass="74177" checksum="5C4E14549A0BF488" modified="2018-04-25" version="1">MSDVRVIIQRDSEREERVVTTGTTAAELFAGERTIVAARVAGELKDLAYAVQDGEEVEPVEISSEDGLNILRHSTAHVMAQAVQELFPDAKLGIGPPVKDGFYYDFDVEKPFTPEDLKAVEKKMQEIQKRGQRFSRRVVTDEAAREELADEPYKLELIGIKGSASTDDGANVEVGGGELTIYDNLDAKTGDLCWKDLCRGPHLPTTRNIPAFKLMRNAAAYWRGSEKNPMLQRIYGTAWPSKDELKAHLEFLAEAEKRDHRKLGNELDLFSIPDQIGSGLAVFHPKGGIIRRVMEDYSRRRHEEEGYEFVYTPHATKGKLFETSGHLDWYADGMYPPMQLDEGVDYYLKPMNCPMHNLIFDARGRSYRELPLRLFEFGTVYRYEKSGVVHGLTRARGFTQDDAHIYCTKEQMAEELDKTLTFVLGLLRDYGLTDFYLELSTKDPEKFVGSDEIWEEATETLRQVAEKQGLPLVPDPGGAAFYGPKISVQAKDAIGRTWQMSTVQLDFNLPERFNLEYTGPDGTKQRPVMIHRALFGSIERFFAVLLEHYAGAFPAWLAPVQAVGIPIGDAHIPYLEEFAAKAKKKGLRVDVDSSSDRMQKKIRNAQKQKVPFMIIAGDEDMAAGAVSFRYRDGSQENGIPVDEAIEKIVKVVEERVQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JLI6</accession>
    <name>A0A2M9JLI6_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Acetylglutamate kinase</fullName>
            <ecNumber evidence="7">2.7.2.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">N-acetyl-L-glutamate 5-phosphotransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">NAG kinase</fullName>
            <shortName evidence="7">NAGK</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7 9" type="primary">argB</name>
        <name evidence="9" type="ORF">CG723_32235</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CB01635</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the ATP-dependent phosphorylation of N-acetyl-L-glutamate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>ATP + N-acetyl-L-glutamate = ADP + N-acetyl-L-glutamyl 5-phosphate</text>
            <dbReference type="Rhea" id="RHEA:14629"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:44337"/>
            <dbReference type="ChEBI" id="CHEBI:57936"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.2.8"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="7">Amino-acid biosynthesis; L-arginine biosynthesis; N(2)-acetyl-L-ornithine from L-glutamate: step 2/4.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the acetylglutamate kinase family. ArgB subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.2.8" evidence="7"/>
    <dbReference type="EMBL" id="NNBL01000018">
        <property type="protein sequence ID" value="PJN07741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN07741">
        <property type="protein sequence ID" value="PJN07741"/>
        <property type="gene ID" value="CG723_32235"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00068">
        <property type="reaction ID" value="UER00107"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003991">
        <property type="term" value="F:acetylglutamate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042450">
        <property type="term" value="P:arginine biosynthetic process via ornithine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04250">
        <property type="entry name" value="AAK_NAGK-C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1160.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00082">
        <property type="entry name" value="ArgB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036393">
        <property type="entry name" value="AceGlu_kinase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004662">
        <property type="entry name" value="AcgluKinase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037528">
        <property type="entry name" value="ArgB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001048">
        <property type="entry name" value="Asp/Glu/Uridylate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001057">
        <property type="entry name" value="Glu/AcGlu_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041727">
        <property type="entry name" value="NAGK-C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00696">
        <property type="entry name" value="AA_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000728">
        <property type="entry name" value="NAGK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00474">
        <property type="entry name" value="GLU5KINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53633">
        <property type="entry name" value="SSF53633"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00761">
        <property type="entry name" value="argB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="1 7" id="KW-0055">Arginine biosynthesis</keyword>
    <keyword evidence="6 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 7 9" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="AA_kinase" evidence="8">
        <location>
            <begin position="29"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="7">
        <location>
            <begin position="69"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="91"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="191"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="7">
        <location>
            <position position="34"/>
        </location>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="7">
        <location>
            <position position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PJN07741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="311" mass="32960" checksum="0A7E9BCA3D4A67B8" modified="2018-04-25" version="1">MSTTRKHTALPKAQILIEALPWLTRHQGKTVVIKFGGNAMIDEDLKAAFAQDVVFLHHAGLKPVVVHGGGPQISKALDRHGIVSEFKAGLRVTTEDAMDVVRMVLAGQVQRELVGLLNEHGPLAIGLTGEDAHTITATKHKPEIGGELVDIGRVGEITEIDTGAIEALLADGRIPVVSSIARSQDDGHVYNVNADTAAAALAAALGAETLMVLTDVEGLYEDWPNSDEVISRLTARQLEKLLPELASGMVPKMEGCLHAVRNGVTTARVIDGRVPHSILLEIFTDEGIGTMVVPDAPEATDVSAIDAQGES</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JLN5</accession>
    <name>A0A2M9JLN5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glutamine synthetase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_32405</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glutamine synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000018">
        <property type="protein sequence ID" value="PJN07772.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN07772">
        <property type="protein sequence ID" value="PJN07772"/>
        <property type="gene ID" value="CG723_32405"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004356">
        <property type="term" value="F:glutamate-ammonia ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006542">
        <property type="term" value="P:glutamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036651">
        <property type="entry name" value="Gln_synt_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014746">
        <property type="entry name" value="Gln_synth/guanido_kin_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008146">
        <property type="entry name" value="Gln_synth_cat_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00120">
        <property type="entry name" value="Gln-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01230">
        <property type="entry name" value="Gln-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54368">
        <property type="entry name" value="SSF54368"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55931">
        <property type="entry name" value="SSF55931"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gln-synt_C" evidence="2">
        <location>
            <begin position="120"/>
            <end position="374"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN07772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="456" mass="50369" checksum="A2025B9F40F28759" modified="2018-04-25" version="1">MADRTPPLGVEELTSLVESGEIDTVVLAFPDMQGRLQGKRFAARFFLDEVLAHGTEGCNYLLAVDTEMNTVDGYEMSSWDRGYGDFAMHADLSTLRRVPWNDGTAMLIADLAWNDASPVVAAPRQILRRQLDRLAEHGYTAHVGTELEFIVFKDTYEQAWDAGYKNLTPANQYNIDYSVLGTGRIEPLLRRIRNDMAAAGLVVESAKGECNPGQHEIVFRYDEALVTCDQHAIYKTGAKEIAAQEGVSLTFMAKFNEREGNSCHIHLSLQDADGTNVMAGTADDPGGMSPVMRHFLAGQLAALRDFSLLYAPNINSYKRFQPGSFAPTAAAWGHDNRTCALRVVGHGRSMRFENRLPGGDVNPHLAVAGLVAAGLYGIEQKLELPEECTGNAYTGEYEHVPTTLREAAELWETSPVAKAAFGDEVVAHYRNMARVELEAFDAAVTDWELRRSFERL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JM35</accession>
    <name>A0A2M9JM35_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GNAT family N-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_31575</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000017">
        <property type="protein sequence ID" value="PJN07918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN07918">
        <property type="protein sequence ID" value="PJN07918"/>
        <property type="gene ID" value="CG723_31575"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013653">
        <property type="entry name" value="FR47"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08445">
        <property type="entry name" value="FR47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="112"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN07918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="248" mass="26525" checksum="BAC4331D1218D0F7" modified="2018-04-25" version="1">MAYPIDVRGDGAAITPNTRHLDNAVWAALTGPHIHFAERLGRAARYPADMYGFAALADPADPAAWADLHTLAGPSTTVRVKGVDRVPSGWEVVGGGRGVQLVDVSLRPEHAPEAVRLGPGDVPEILELVARTRPGPFLARTVELGTYLGIRQQGRLIALAGERLRLPGWTEISAVCTDPAHRGQGLATRLVRAVAAGIRERGETPFLHAAATNKTAIRLYQSIGFTLRTRTRILQVRTPGTGSGPRPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JM60</accession>
    <name>A0A2M9JM60_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Peptide ABC transporter substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_31625</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000017">
        <property type="protein sequence ID" value="PJN07954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN07954">
        <property type="protein sequence ID" value="PJN07954"/>
        <property type="gene ID" value="CG723_31625"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042597">
        <property type="term" value="C:periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030678">
        <property type="entry name" value="Peptide/Ni-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039424">
        <property type="entry name" value="SBP_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000914">
        <property type="entry name" value="SBP_5_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30290">
        <property type="entry name" value="PTHR30290"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00496">
        <property type="entry name" value="SBP_bac_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002741">
        <property type="entry name" value="MppA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SBP_bac_5" evidence="1">
        <location>
            <begin position="67"/>
            <end position="431"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN07954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="530" mass="58112" checksum="824D08EB68660206" modified="2018-04-25" version="1">MLLATACGAGEAATSVTARPAAGGTLTYATDREPTCLDPHVAGDMPQAYVAQQVLDSLVALDAEGEAKPWLAASWDISEDGRTYTFHLRDDVRFTDGTRFDAVAVKANFDHMVDPDTQSGTAGGYLAPYQRTDVVDEFTARVHLDRPYSPFLNMLAQAFLAMESPKALARGKEANCAAPVGTGPFIVKKWNRQSDVVLVRNPHYNSPPPYAKHSGPAYAEKIVWRFIPEPATRFAAVQSGQVDVIDALPPEDQRTAEHDDRLKVVVRDRPGNPTNLALNTSRAPFDDIRVRKAFLYSADVADGLKSVFFGQYRRAGGPLSYVTPHYSDAYENAWPYDPEKANTLLDQAGWGKRDGDGYRVKGTGRLTAEVLLKSDISPNQLAVMEQIQATAKDVGFQLKLLRLDAATVNTRYLAGKYDLRDGYWNTNTPDVLHTVFGSEYAVQNGIHSNATYAKDPALDRLFRTAQATTDPDEQQKLYGAAQRLISAGAYQLTLYPQTTRLAAHDGSVRGAALEPALSLPYLYDAWVSSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JMC1</accession>
    <name>A0A2M9JMC1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_31735</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000017">
        <property type="protein sequence ID" value="PJN07937.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN07937">
        <property type="protein sequence ID" value="PJN07937"/>
        <property type="gene ID" value="CG723_31735"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="46"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN07937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="99" mass="10796" checksum="7BC822F205D0A728" modified="2018-04-25" version="1">MHQLATNLVLTRTYLLFVLSSLCVYTVLWGMTQWLQVARGMSSKEAGLLLLPMSALLALLVRPISRRNLIRSTAPGRATGRSIEERAVGRPLVTAGCTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JMF0</accession>
    <name>A0A2M9JMF0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Acetolactate synthase large subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CG723_30710</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CB01635</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TPP enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000016">
        <property type="protein sequence ID" value="PJN08055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08055">
        <property type="protein sequence ID" value="PJN08055"/>
        <property type="gene ID" value="CG723_30710"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030976">
        <property type="term" value="F:thiamine pyrophosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012001">
        <property type="entry name" value="Thiamin_PyroP_enz_TPP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045229">
        <property type="entry name" value="TPP_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011766">
        <property type="entry name" value="TPP_enzyme-bd_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18968">
        <property type="entry name" value="PTHR18968"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02775">
        <property type="entry name" value="TPP_enzyme_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02776">
        <property type="entry name" value="TPP_enzyme_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TPP_enzyme_N" evidence="4">
        <location>
            <begin position="1"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="domain" description="TPP_enzyme_C" evidence="3">
        <location>
            <begin position="374"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="165"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PJN08055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="517" mass="52705" checksum="A5C0F1210A44B211" modified="2018-04-25" version="1">MNGAQSLIRTLVGAGVEVCFANPGTSEMHFVAALDSVPEMRGVLGLFEGAVTGAADGYARIAGKPAATLLHLGPGLGNGLANLHNARRAHTPIVNVVGDHATHHKKYDAPLESDIEPVAGSVSGWVRRSGQVAEVGADAAAAVAASMEAPGQVATVILPADASWDEGGQVAEPQPSRTSAAPDPQTVSSIADILRSGEPAALLIGGAACREPGLVATSRIANATGVRALVETFPARLERGAGLPAIERLRYLAEQAVRQLDGVKHLIVAGTRSPVSFFAYPGKPSDLVPEGAQVHTLADPSQDVVAALEALAERVAADTLPTLAEPALPSLPSGPLTANNWAEVIGALLPAGAIISDEANTSGAALPAATAGAPRHDVLTLTGGAIGQGIPVATGAAIAAPDRPVINLEADGSAMYTISALWTQARENLDVTTVILNNSAYAVLRLEMLRVGADLSGPAAKTLLDLSSPDLNFAKIAEGMGVPSSRATTCEELAEQLRRAFAEPGPHLIDAVVPPHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-09-29" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JMK1</accession>
    <name>A0A2M9JMK1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Diguanylate cyclase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_30125</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000016">
        <property type="protein sequence ID" value="PJN08096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08096">
        <property type="protein sequence ID" value="PJN08096"/>
        <property type="gene ID" value="CG723_30125"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00077">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006674">
        <property type="entry name" value="HD_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01966">
        <property type="entry name" value="HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HD" evidence="1">
        <location>
            <begin position="35"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN08096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="215" mass="23811" checksum="3801B28A6D724AD6" modified="2018-04-25" version="1">MNNDGAAVAGVAVPDTKLAREAEQLVRDTTSELIYHHSRRVFFFGALQGRKLDLSYDPELVYIGALFHDLGLSERFHGSGRRFEVDSADEAQRFLTARDVPPDSVRRVWTAIALHTTPGVPQHMEPEVALVTAGVEYDVLGIGYDDLSAADRADIVALHPRPDFKHRILAAFTDGVAPKPDTTFGNVKADVLAHYVPGFERGDFVRTILDSKWEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JNH9</accession>
    <name>A0A2M9JNH9_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ParB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CG723_29010</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CB01635</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ParB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000014">
        <property type="protein sequence ID" value="PJN08419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08419">
        <property type="protein sequence ID" value="PJN08419"/>
        <property type="gene ID" value="CG723_29010"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004437">
        <property type="entry name" value="ParB/RepB/Spo0J"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003115">
        <property type="entry name" value="ParB/Sulfiredoxin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036086">
        <property type="entry name" value="ParB/Sulfiredoxin_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02195">
        <property type="entry name" value="ParBc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00470">
        <property type="entry name" value="ParB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110849">
        <property type="entry name" value="SSF110849"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00180">
        <property type="entry name" value="parB_part"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ParB" evidence="3">
        <location>
            <begin position="38"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="210"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PJN08419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="272" mass="29583" checksum="4E27EB43CC9BA2C9" modified="2018-04-25" version="1">MGRRTDLSSLLSSGAAAPAPEPSQGDAQPVARDAAHPVTVALADLAENPDNPRHELRDLDGLAETVRERGVLQALGVVPRAVFVAAHPHHEEAVGRAPYVVLHGHRRLAAARMAGLDEVPVLVREDASRTDEDALIENVQRDDLTELEQAQAIQGLIRSYGYSQRQVAARIGKTQGFVSQRLSLMKLREDLQEALADGRVSVEDARRIARLPQEEQALPGDTGTPPPSVPKARRDYGVIKIDSRGTPEEVVESLRRHLAPAALDRILELLAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JNK8</accession>
    <name>A0A2M9JNK8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alpha-ketoacid dehydrogenase subunit beta</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_29180</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000014">
        <property type="protein sequence ID" value="PJN08449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08449">
        <property type="protein sequence ID" value="PJN08449"/>
        <property type="gene ID" value="CG723_29180"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009014">
        <property type="entry name" value="Transketo_C/PFOR_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005475">
        <property type="entry name" value="Transketolase-like_Pyr-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033248">
        <property type="entry name" value="Transketolase_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02779">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02780">
        <property type="entry name" value="Transketolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00861">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52922">
        <property type="entry name" value="SSF52922"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transket_pyr" evidence="1">
        <location>
            <begin position="6"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN08449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="326" mass="35626" checksum="E5AE15792A39C8C9" modified="2018-04-25" version="1">MAVQKLPLAKAINESLRLALETDPKVLIMGEDVGKLGGVFRVTDGLQKDFGEDRVIDTPLAESGIVGTAIGLALRGYRPVVEIQFDGFVFPAYDQIVTQLAKMHARALGKIKLPVVVRIPYGGGIGAVEHHSESPEALFAHVAGLKVVSPSNSSDAYWMMQQAIQSDDPVIFFEPKRRYWDKGEVDTEAIPGPLHGARTLREGTDLTLVAYGPMVKVCLEVAAAAQEEGKSLEVLDLRSMSPIDFDAVQKSVEKTRRLVVVHEAPVFLGTGAEIAARITERCFYHLEAPVLRVGGYHVPYPPARLEDEYLPGLDRVLDAVDRSLAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JNQ9</accession>
    <name>A0A2M9JNQ9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">IclR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CG723_29015</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000014">
        <property type="protein sequence ID" value="PJN08500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08500">
        <property type="protein sequence ID" value="PJN08500"/>
        <property type="gene ID" value="CG723_29015"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046278">
        <property type="term" value="P:3,4-dihydroxybenzoate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045893">
        <property type="term" value="P:positive regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012318">
        <property type="entry name" value="HTH_CRP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012794">
        <property type="entry name" value="PcaR_PcaU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014757">
        <property type="entry name" value="Tscrpt_reg_IclR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005471">
        <property type="entry name" value="Tscrpt_reg_IclR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09339">
        <property type="entry name" value="HTH_IclR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01614">
        <property type="entry name" value="IclR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00419">
        <property type="entry name" value="HTH_CRP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00346">
        <property type="entry name" value="HTH_ICLR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02431">
        <property type="entry name" value="pcaR_pcaU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51077">
        <property type="entry name" value="HTH_ICLR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51078">
        <property type="entry name" value="ICLR_ED"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH iclR-type" evidence="4">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="domain" description="IclR-ED" evidence="5">
        <location>
            <begin position="58"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="domain" description="HTH iclR-type" evidence="4">
        <location>
            <begin position="291"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="domain" description="IclR-ED" evidence="5">
        <location>
            <begin position="352"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="248"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PJN08500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="546" mass="57522" checksum="C1C1BD69AA6FA2B3" modified="2018-04-25" version="1">MRGIDVLRRLTDAGGTLSLSELARATGLARSTVDRICATLAHMGCLRLDGRDATLAPPLMAVGNACLSALRVPALLGPRAERLADELDESVSLAVPDGDGIRFIHQATRRRAMSLSFRIGDLLPAERTAPGPLFAGAWDVDMWARWRARRAADPEDRGFPAVPPRQEPEKEPFEECVARAGAAGWALDDQLIEPGLVALAVPVRGPGGDIACVVSVVSHTSRHTAASLREAMLGRLRAAVTEMEAALREPAPEGPAPGPGPDAPAPTGAQAKGPDAAWAAEAKQRLGRDFVESLARGLAVLTVFGAGRAELNLTEIAAATGLARATARRALITLEYLGYVASRGRGFRLTPRVLALGFPPLSHLTLAEIATPHMRALSAELHDSVSLTVLDGDDIRYTARVATSRVMSVNISVGTRFPAFATSMGRVLLAGLAPHARAAFLARADLTPLTPRTVTGADRLGALLDDVQRQGHALVDGELEEGLRSVAVPVRDLAGQVVAAVNVATHSSRRDLARVTDEVLPALLATASRIEADLHVAGRFARIPAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-09-29" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JNS6</accession>
    <name>A0A2M9JNS6_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex</fullName>
            <ecNumber evidence="3">2.3.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CG723_29250</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CB01635</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 3">
            <name>(R)-lipoate</name>
            <dbReference type="ChEBI" id="CHEBI:83088"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 3">Belongs to the 2-oxoacid dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.-" evidence="3"/>
    <dbReference type="EMBL" id="NNBL01000014">
        <property type="protein sequence ID" value="PJN08505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08505">
        <property type="protein sequence ID" value="PJN08505"/>
        <property type="gene ID" value="CG723_29250"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.320.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001078">
        <property type="entry name" value="2-oxoacid_DH_actylTfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000089">
        <property type="entry name" value="Biotin_lipoyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036625">
        <property type="entry name" value="E3-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004167">
        <property type="entry name" value="PSBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011053">
        <property type="entry name" value="Single_hybrid_motif"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00198">
        <property type="entry name" value="2-oxoacid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00364">
        <property type="entry name" value="Biotin_lipoyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02817">
        <property type="entry name" value="E3_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47005">
        <property type="entry name" value="SSF47005"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51230">
        <property type="entry name" value="SSF51230"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50968">
        <property type="entry name" value="BIOTINYL_LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51826">
        <property type="entry name" value="PSBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="3" id="KW-0450">Lipoyl</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Lipoyl-binding" evidence="5">
        <location>
            <begin position="4"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="domain" description="Peripheral subunit-binding (PSBD)" evidence="6">
        <location>
            <begin position="147"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="107"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="129"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001938"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PJN08505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="442" mass="46432" checksum="BA32D03D9C198EA1" modified="2018-04-25" version="1">MAQVLEFKLPDLGEGLTEASIVTWLVQVGDVVAVDQPVVEVETAKAMVEVPCPYGGVVTARFGEEGTELPVGSPLLTVAVGTPAEGEGDDEGSGNVLVGYGTAAAPARRRRVRRQDDLPVAAPAAPTRNAPSAPVPEAPPRSGPVPVISPLVRKLAREHGVDLRELPGSGPEGLIMRADVESAMRETVQVRAHVAEAEVVAPAPAQAPVGGTADGIRVPLRGLRGAVADKLTRSRREIPDATCWVDADATEFMHARVAMNAAGGEKISVLALLARICTAALARYPELNSRVDMAAREVVQLDAVHLGFAAQTERGLVVPVVKDAHVRDAESLSAEFARLTDAARAGRITPGELTGGTFTLNNYGVFGVDGSTPIINHPEAAMLGVGRIIPKPWVHQGELAVRQVVQLSLTFDHRVCDGGTAGGFLRYVADCIEQPAVLLRTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JNV8</accession>
    <name>A0A2M9JNV8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Hydroxylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_27680</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000013">
        <property type="protein sequence ID" value="PJN08559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08559">
        <property type="protein sequence ID" value="PJN08559"/>
        <property type="gene ID" value="CG723_27680"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016040">
        <property type="entry name" value="NAD(P)-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13460">
        <property type="entry name" value="NAD_binding_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD(P)-bd_dom" evidence="1">
        <location>
            <begin position="11"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN08559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="300" mass="32652" checksum="D49518695E0E3B72" modified="2018-04-25" version="1">MTADNLVLIPGAGGVGRTVFEHLRAQDVPVRFMVRRDDERAAELRALGAEVVIGDLTRPETVAAALQGVSRMHFGISVSPDQLLAATVVASVAREYGELAALVDLSQMTVSQMTATSTEESHQQRLHWLTEQMFDWSGLPVVHVRPTAFLDNPLFTTIAARSIQANGTIALPFGTGRTSPVAADDVARTIATVLRDPAPHIGQVYELTGPRSVDMTELAAEFSRALNRPVSYVDLPPDRWEAQLPKLGMSPHLAQHVATMARLHRDNRNDRTADGVERVTGTPAMSIEAFVAARRDFYLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JPD6</accession>
    <name>A0A2M9JPD6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_26975</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000012">
        <property type="protein sequence ID" value="PJN08730.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08730">
        <property type="protein sequence ID" value="PJN08730"/>
        <property type="gene ID" value="CG723_26975"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046195">
        <property type="entry name" value="DUF6227"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19738">
        <property type="entry name" value="DUF6227"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN08730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="256" mass="28589" checksum="3EE1CA879BADFEA7" modified="2018-04-25" version="1">MSVPYDTAAYEPPESHESHQPDGTHQPDEHLGRLLGRALNSFELPDEALARLDCALAYDSSLHSAHHSAGLHRETYRHTWLLADGSALTLWELVHNTTPGRGTQHEVYTSEDDLHLATDRLPLPREAAPDFELPLPLQLPSIPEPRRSYAADDSADHARRLLRRAENEDRPGPGTAGLLHTACAHQITQAFGRPRLGFTLYEHAFLLHDGSEISLWEIEHTATPDGRHMCEVYATQDEARAAMKRRATDRSRPSCG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JPL2</accession>
    <name>A0A2M9JPL2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">TetR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CG723_26960</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000012">
        <property type="protein sequence ID" value="PJN08727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08727">
        <property type="protein sequence ID" value="PJN08727"/>
        <property type="gene ID" value="CG723_26960"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="3">
        <location>
            <begin position="16"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="39"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="158"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PJN08727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="247" mass="24810" checksum="605A9FA4624C42AF" modified="2018-04-25" version="1">MPGSSTTETLTERRKAATRLDIARTAAALFVEDGLRATRAEDIARAAGVAPRTFYRYFATKEEAVAPLFAAGAQRWAEAVRDAPAALSVPEALRHAVAQSLTADDAANVESLEWVRSLLRMAAESPALQAVWGTACHASEATLLAVLAERVGAITSGGSGGSGDLGRSGGAGGASDSGGVGAHDGSGASQAPASLALRMAAGVACTAIRVGVETWAASDAPVDGELGPAALAARCLASLGDFPWAPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JPM7</accession>
    <name>A0A2M9JPM7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Resuscitation-promoting factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CG723_27200</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CB01635</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the transglycosylase family. Rpf subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000012">
        <property type="protein sequence ID" value="PJN08820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08820">
        <property type="protein sequence ID" value="PJN08820"/>
        <property type="gene ID" value="CG723_27200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd13925">
        <property type="entry name" value="RPF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007137">
        <property type="entry name" value="DUF348"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011098">
        <property type="entry name" value="G5_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023346">
        <property type="entry name" value="Lysozyme-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010618">
        <property type="entry name" value="RPF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03990">
        <property type="entry name" value="DUF348"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07501">
        <property type="entry name" value="G5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06737">
        <property type="entry name" value="Transglycosylas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01208">
        <property type="entry name" value="G5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53955">
        <property type="entry name" value="SSF53955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51109">
        <property type="entry name" value="G5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="domain" description="G5" evidence="4">
        <location>
            <begin position="235"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010830"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PJN08820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="402" mass="43680" checksum="9B0C9E4333EE02B4" modified="2018-04-25" version="1">METQPAWQVPEALLPRQSAPAAGRAEARRAARRRKRPERPETLRRLLPQALVVVFLAGGTTAFVAADKAVQLSVEGRPRTLHTFADDVGELLADEGVDVGPHDVVAPAPGTALASGDEVTVRYGRLVHLTIDGQRRQVWTTAGTVDGALHQLGVRAEGAYVSASRSRRIARDGLEFDVRTERSVMVMADGRERTIRTNAATVRDAVDEAGISLHGQDTTSVPQDSFPRDGQTITVMRIKGSKEVREEVIEYAVERTQDPTLFRGTEVVERAGRQGARRVTYALRTVNGVKQKPRRMSAEVVREPRSQVVKVGTKPLPPSVAGADGLNWSELARCESGGRPSATDATGTYGGLYQFDVQTWRSLGGGGRPQDASASEQTYRAKKLYVRRGASPWPHCGGRLHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JQ85</accession>
    <name>A0A2M9JQ85_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_26260</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000011">
        <property type="protein sequence ID" value="PJN09030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN09030">
        <property type="protein sequence ID" value="PJN09030"/>
        <property type="gene ID" value="CG723_26260"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="255"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="255"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN09030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="326" mass="35690" checksum="04DE43259979B00F" modified="2018-04-25" version="1">MRIFGKGRHRPSASWRQATDRAFTLIGDGRYEDAGALLTRAADLEPWLSESWFNLALLHKFRHDWEQARAAGLRAVALLDRESGAPDWWNVGIAATALQDWPLARRAWQAYGLKVPGGATAAGEPTGMDLGSAAVRLSPEGEAEVVWGRRLDPARMEVLSIPLPSSGRRWGEVVLHDGVPHGERTTAAGHSYPVFDEIELWAPSPVPTWVVLLEAATEADRDALEQLASDAGFAAEDWSSSVRLLCRMCSESRMPSDEGDGEHLDPHDHSEPGHPGPLGHRTDGQLWVPERECGVAAPAALVRGLLDGWVADSPDSRDWRDLEEVC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-06-02" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JQA4</accession>
    <name>A0A2M9JQA4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_24335</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000010">
        <property type="protein sequence ID" value="PJN09061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN09061">
        <property type="protein sequence ID" value="PJN09061"/>
        <property type="gene ID" value="CG723_24335"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021373">
        <property type="entry name" value="DUF2993"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11209">
        <property type="entry name" value="LmeA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="78"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="45"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN09061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="419" mass="45205" checksum="9292B34391A64B4B" modified="2018-04-25" version="1">MSTDPSDAWTEESVPSDTVSSRTAPSGTAPPNPYDELGALADNPLDEFLHEEDPEAGPDDQPWSRPNHRRGSRRRNRFAGLPLATKAVVGILVLAAFLTLADRWALLYAEHRAADRLKDQLHLSAAPEVDIEGFPFLTQLADRRLDEVKVTVPDVAASRVSLAKVSATIRDVTIDGDGLTDVRGARIGGMTGEVLLTFDDLNRELGASQVAFSGQGRDRVLARGTLPVAGHDLRVRADATIRRIGDTGIATDIGGMRLDIGDLATYRPGTRPSEGLHLSRRSVTRLATETAKAKALLSVPSLVHRLGVPDSAVRAALRSDRRLSELTGSPRFVHQLMSLNLVDLALAHPALLKKFGLDPALLQGLTRLTRPELADRLSLAFRLPKLPGDGMGDVRLSDVKVEKDGIRVGLTGEGLGFER</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JQE7</accession>
    <name>A0A2M9JQE7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Nitrate ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CG723_26365</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CB01635</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000011">
        <property type="protein sequence ID" value="PJN09007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN09007">
        <property type="protein sequence ID" value="PJN09007"/>
        <property type="gene ID" value="CG723_26365"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="36"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="95"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="128"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="153"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="197"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="243"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="87"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PJN09007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="287" mass="30890" checksum="59668A6C8AB6A242" modified="2018-04-25" version="1">MTTTAPKEDTTLLVRRPGPQELHPARTHRRRRALELSLAVAVPLVLVLLWQLAATQAWIDDRVYPAPSTILVDGWHRAADGDLWPDVWATLKRVLAGYAIGTVTGYALGLLMGSLSMVRAALEPMLDALYVVPKLALLPIFLNMFGLGEGPQIALVATTVFFFVWISTMAAVLAVPSGHRDAGQVFGASPWQMFRHVLLPASLPAVLVGARIAAGVAVLVIVASEQIAATNGLGHLIFDARALFQNDVMFVGIVCVAVLGVVFSELVRIAGRLLTPWAPRDRGRGQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JQJ4</accession>
    <name>A0A2M9JQJ4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Hydroxyurea phosphotransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CG723_24845</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000010">
        <property type="protein sequence ID" value="PJN09143.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN09143">
        <property type="protein sequence ID" value="PJN09143"/>
        <property type="gene ID" value="CG723_24845"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016773">
        <property type="term" value="F:phosphotransferase activity, alcohol group as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019748">
        <property type="term" value="P:secondary metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006748">
        <property type="entry name" value="NH2Glyco/OHUrea_AB-resist_kin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04655">
        <property type="entry name" value="APH_6_hur"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PJN09143.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="293" mass="31862" checksum="F53D65D76076E182" modified="2018-04-25" version="1">MIDIPDGLVESQYTYAGDPGRAFIAGLPARVEEFVERWDLRVDGPAMHGMAALVLPVVRGDGTPAAVKFQILDEETEGEPVALRVWDGDGAVRLLDHDDATGTMLLERLDSGRMLDSVEDSRKAVLVIAELLARLTSGPAPEGMRRLADIAADMLAQVPSALAAVADPADRALLADCAAAVREVAGEAGNRLLHWDLHFENVLAAAREPWLAIDPKPLAGDPGFDLKPAIDNRFDADEVVWRFDAMSGVLGLDRERARAWTLGRVLQDSLWEIEDGRPLAPDHMETARRLLGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JR23</accession>
    <name>A0A2M9JR23_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">3-hydroxybutyryl-CoA dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CG723_23355</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000009">
        <property type="protein sequence ID" value="PJN09292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN09292">
        <property type="protein sequence ID" value="PJN09292"/>
        <property type="gene ID" value="CG723_23355"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070403">
        <property type="term" value="F:NAD+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022694">
        <property type="entry name" value="3-OHacyl-CoA_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006176">
        <property type="entry name" value="3-OHacyl-CoA_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006108">
        <property type="entry name" value="3HC_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00725">
        <property type="entry name" value="3HCDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02737">
        <property type="entry name" value="3HCDH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000105">
        <property type="entry name" value="HCDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="SSF48179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="3HCDH_N" evidence="3">
        <location>
            <begin position="7"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="domain" description="3HCDH" evidence="2">
        <location>
            <begin position="189"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="site" description="Important for catalytic activity" evidence="1">
        <location>
            <position position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR000105-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PJN09292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="287" mass="30490" checksum="CC7A02F3706F21B5" modified="2018-04-25" version="1">MTAISRLGVVGCGLMGSGIAEVAALRGLDVTVAESTPELASAGRARVTASLDRGLRRSKLTEADRDQALARLSFTHDLGDLSDRQFVVEAVAENREVKLEVFRQLDKVLADPQAVLATNTSSLPVVDLAVATGRASQVVGLHFFNPVPVQKLVEVIPSLTTGADTLARARDFAAEGLGKEVVQAPDRSGFVVNALLVPYLLAAIRMVESGAARPEDIDRGMELGCAQPMGPLRLLDLIGLDTAQAVAESLYEEFKEPLYAAPPLLQRMVAAGHLGRKSGRGFYAYDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JR75</accession>
    <name>A0A2M9JR75_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Sugar ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CG723_23995</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CB01635</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000009">
        <property type="protein sequence ID" value="PJN09390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN09390">
        <property type="protein sequence ID" value="PJN09390"/>
        <property type="gene ID" value="CG723_23995"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="27"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="88"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="120"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="151"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="194"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="250"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="84"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PJN09390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="286" mass="30736" checksum="6835973B4E055AF5" modified="2018-04-25" version="1">MSATLTPARPSLAPPFRRRRRLAWLRGTAIGLVTLVFALPLVWMFAAAFKTNLQVTDPSVGLWFTPTLDNFRNVVEAGQIVRSMGNSLLVGAVSTALSAVIAVPAAWAVGRFGMRRTGSVILIARIVPAISLLVPWYYLFAQIGLVGSYTVLILSHMFVSVPLIMWIMISFFAGLPVELEEAARTDGLSAFGAFWRISLPLAAPGTATASLLAFVFSWNNFMFALVFADDRTQTVPVTLFNFISYASTDWGGLMAASTLITVPVVIAAVLGQKYLVAGLTSGATKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-09-29" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JRQ4</accession>
    <name>A0A2M9JRQ4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Cellulase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CG723_22785</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CB01635</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the glycosyl hydrolase 5 (cellulase A) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000008">
        <property type="protein sequence ID" value="PJN09565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN09565">
        <property type="protein sequence ID" value="PJN09565"/>
        <property type="gene ID" value="CG723_22785"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005102">
        <property type="entry name" value="Carbo-bd_X2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040946">
        <property type="entry name" value="CBM46"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001547">
        <property type="entry name" value="Glyco_hydro_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016282">
        <property type="entry name" value="Glyco_hydro_5_endoGlcnase_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18448">
        <property type="entry name" value="CBM46"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03442">
        <property type="entry name" value="CBM_X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00150">
        <property type="entry name" value="Cellulase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001043">
        <property type="entry name" value="Endoglucanase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="SSF81296"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="3 4" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014876961" evidence="5">
        <location>
            <begin position="35"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="domain" description="Cellulase" evidence="6">
        <location>
            <begin position="69"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="domain" description="CBM_X2" evidence="7">
        <location>
            <begin position="378"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="domain" description="CBM46" evidence="8">
        <location>
            <begin position="467"/>
            <end position="571"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU361153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF03442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF18448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PJN09565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="574" mass="62656" checksum="C4DDEF0E5435C798" modified="2018-04-25" version="1">MRQARSRRRRVGPVAGLFLVLLATVGTSRTGAVAAARPAPAATGSAMDTVAAMQPSWNLGNTLDAIPDETSWGNPPATKALFDTVKSQGFRSVRIPVTWGNHQSAQAPYTIDAAFLSRVRQVVDRAQADGLRVVLNVHHDSWQWINKMATDHDQVLARYHATWQQIATAFKDEPRTLLFESINEPAFDNADDARKMELVDELNTSFHSIVRASGGANAQRLLVLPTVGATPDQTLMDDLAATIDGLDDPNLVATVHYYSFWPFSVNIAGYTRFDATVQQDMTDAFARMHDTFVTKGIPVYLGEYGLLSYPDYTHQDYVERGEALKYFEALGHTARVNGVTTALWDPFSLLNRETLRWRDPALFALIKSSWTTRSGTASSDKVYVRKADPVTDQSLTLNLNGTSFRGLWQGGNELGRGVDYTVSRDRLTLTAAALTRLTGDRAYGVNATLQARFSSGVPWRIDVTTYDPPLLADATGTTGSFAAPARFRGDSLATMEATYADGTNAGPADWTSYQQFGTAFAPDYDDGTLRLTADFLNSLGDGVPVTLTFHFWSGAAITYQVTRSGDTVTGTAVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JRS9</accession>
    <name>A0A2M9JRS9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_22315</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000008">
        <property type="protein sequence ID" value="PJN09497.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN09497">
        <property type="protein sequence ID" value="PJN09497"/>
        <property type="gene ID" value="CG723_22315"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018691">
        <property type="entry name" value="DUF2188"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09954">
        <property type="entry name" value="DUF2188"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="38"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="76"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN09497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="97" mass="10485" checksum="EBB2211D8ECE8C09" modified="2018-04-25" version="1">MAAKQTVYHVTPSGERAADAGVKWQVEGREGRRLLHEPHRTQKDAIDSARDRAKEHTPAQVVVHARDGHIRTAYAYGDASAGSPDNRGRKAGGGGLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JRX8</accession>
    <name>A0A2M9JRX8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ribonuclease BN</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CG723_22445</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CB01635</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000008">
        <property type="protein sequence ID" value="PJN09631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN09631">
        <property type="protein sequence ID" value="PJN09631"/>
        <property type="gene ID" value="CG723_22445"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017039">
        <property type="entry name" value="Virul_fac_BrkB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03631">
        <property type="entry name" value="Virul_fac_BrkB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="85"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="123"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="146"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="175"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="215"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PJN09631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="256" mass="27725" checksum="73C3A3438843CFED" modified="2018-04-25" version="1">MRRVRAGRRWVHVGNLDLWQRSLGFAALGFLTLVPLLIVVSAADPASGRGFAKWLGDGLGVTEAARGDIERLFALPGQTLRTTTAFGLAVLAVFGLSFGAAVQSGYEKVWDLPPARWWARWRHVVWLAVLIGFLFLSAITPLWQAAPARGVITALSGTLFFWWSQRMLLGGRVSWVALLPGAVTTMAGQLGLRVFSRLVFSPLIASSAVTYGPIGTVLVIQSWLVGVGVVVFGGALAGRCLQDELPRVAHALKRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JSL0</accession>
    <name>A0A2M9JSL0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DUF397 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_21825</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000007">
        <property type="protein sequence ID" value="PJN09864.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN09864">
        <property type="protein sequence ID" value="PJN09864"/>
        <property type="gene ID" value="CG723_21825"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007278">
        <property type="entry name" value="DUF397"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04149">
        <property type="entry name" value="DUF397"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF397" evidence="2">
        <location>
            <begin position="34"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN09864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="99" mass="10763" checksum="7DA114E1C2189FDB" modified="2018-04-25" version="1">MGSDAAGESSEEVKARKEREKNELYALDISDAEWHSAPGTEDHEERVEIAYLPAGAVAMRSSVDPETVLRYTEAEWTAFVLGARDGEFDLEDAAGDGGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-09-29" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JT86</accession>
    <name>A0A2M9JT86_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Disulfide bond formation protein DsbA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_20495</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000006">
        <property type="protein sequence ID" value="PJN10090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN10090">
        <property type="protein sequence ID" value="PJN10090"/>
        <property type="gene ID" value="CG723_20495"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012336">
        <property type="entry name" value="Thioredoxin-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13462">
        <property type="entry name" value="Thioredoxin_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014689686" evidence="1">
        <location>
            <begin position="36"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin-like_fold" evidence="2">
        <location>
            <begin position="58"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN10090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="241" mass="25956" checksum="98266DBEE3672D7C" modified="2018-04-25" version="1">MLRGRGRRVAIPVLVAALTGVLAAGCGRGPSGGDAADARKPERFASSRQLPEHLAADGTTVVVGSSKADTVVRLYEDLRCPVCRDFEEDGGAGALRKMTLHGEVRAEYTLASFLDDRLGGKGSKKAANALRAALEKGKFVEYHDLLFQEQPEEAVDGYTDAFLLRMASRVKGLRGAEFDAAVKGMKYRPFVTASEKAYEADKAPGTPAFAVNGTLISEDRWNLMFDPKYVPLAVMTSTLPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JTQ2</accession>
    <name>A0A2M9JTQ2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CG723_17895</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000005">
        <property type="protein sequence ID" value="PJN10265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN10265">
        <property type="protein sequence ID" value="PJN10265"/>
        <property type="gene ID" value="CG723_17895"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015833">
        <property type="term" value="P:peptide transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013563">
        <property type="entry name" value="Oligopep_ABC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08352">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="6"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="38"/>
            <end position="45"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PJN10265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="265" mass="28442" checksum="1D99B30DFBB9C70D" modified="2018-04-25" version="1">MSETVLQVTGVSRSYRSVRAADDVSFTLGVGGSLGIVGESGSGKTTTARIVVGLERADAGEVLVRGVSRTVRARGRAARLARAREVQMVFQDPFLSLDPRITVDATLRETLRLHFPDGDHSHRLGELLDQVGLGSRAAGALPRQLSGGQRQRVAIARALAVEPAVLVLDEAVAALDVSVQAQILNLLADIREQTGIAYLFITHDLGVVRCVTDDVIVMRQGRIVESGPTPQVLDAPQHAYTRLLLESIPRPGWNPQAIALARRAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JTR7</accession>
    <name>A0A2M9JTR7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CG723_17890</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000005">
        <property type="protein sequence ID" value="PJN10264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN10264">
        <property type="protein sequence ID" value="PJN10264"/>
        <property type="gene ID" value="CG723_17890"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015833">
        <property type="term" value="P:peptide transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013563">
        <property type="entry name" value="Oligopep_ABC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08352">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01727">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="8"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="42"/>
            <end position="49"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PJN10264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="332" mass="35168" checksum="7C24604C9A14B31A" modified="2018-04-25" version="1">MNDTPPVLDIQGLRLQLPDTARPVLDGVDLTVAAGETVALVGESGSGKSLTSRSVLGLLPPGATAEGTVRVSGDDVLTMTPARLRELRTGTAAMIFQDPRAAINPLRRIGDFLTESLRLNAGMRAEDAARRAVEMLAAVGLSSDALRRYPGQLSGGMLQRVMIAAALMGDPALLLADEATTALDVTTQAEVVGLLGDLRERFGTGLLFVTHDLGLAATISDRVYVMYAGRIAETGPAEALFDRPRHPYTAALLEATPRLDAPQGRLAAIDGQPPDLRQELTGCPFAPRCAYATGICRDEAPVDRPAGDDDGLLRHRVACHHSERLEGKSGHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JTW4</accession>
    <name>A0A2M9JTW4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_18235</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000005">
        <property type="protein sequence ID" value="PJN10320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN10320">
        <property type="protein sequence ID" value="PJN10320"/>
        <property type="gene ID" value="CG723_18235"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014902922" evidence="1">
        <location>
            <begin position="19"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN10320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="150" mass="15591" checksum="11E0F789E28BE925" modified="2018-04-25" version="1">MAVLLGCLVLACASCADAGGEAAVIQQADLVGDWANSAGAHVHMAGDHTVTASGVDHAVPDYTCPTTVKAARWQFFTQADSSGFATASDSVTEGDSLVVTVDAGDPDSQWCDLQAAVQRDYRGFNLCLVLDMDQGCTAGELLRRVPAARE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JTW6</accession>
    <name>A0A2M9JTW6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">TetR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CG723_18195</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000005">
        <property type="protein sequence ID" value="PJN10314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN10314">
        <property type="protein sequence ID" value="PJN10314"/>
        <property type="gene ID" value="CG723_18195"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025996">
        <property type="entry name" value="TetR_C_WHG"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13305">
        <property type="entry name" value="TetR_C_33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="5">
        <location>
            <begin position="5"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="4">
        <location>
            <begin position="28"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PJN10314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="189" mass="20518" checksum="9E88542356FEDDF4" modified="2018-04-25" version="1">MVRVGLTRERLIRAGAELADEVGFDNVTVSALARQFDVKVASLYSHLKNSQELKTGIALLALEELADRGAAALAGRAGKDALAAFANVYRDYAREHPGRYAAAQLRLDPETAAASAGVRHARMMRAILRGYDLTEPDQTHAVRLLGSVFHGYVSLEMQGGFSHSAPDSQESWSRILDSLDATLRNWPAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JUH4</accession>
    <name>A0A2M9JUH4_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 6">Cell division ATP-binding protein FtsE</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6 8" type="primary">ftsE</name>
        <name evidence="8" type="ORF">CG723_14960</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CB01635</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Part of the ABC transporter FtsEX involved in cellular division.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homodimer. Forms a membrane-associated complex with FtsX.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
            <topology evidence="6">Peripheral membrane protein</topology>
            <orientation evidence="6">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the ABC transporter superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000004">
        <property type="protein sequence ID" value="PJN10524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN10524">
        <property type="protein sequence ID" value="PJN10524"/>
        <property type="gene ID" value="CG723_14960"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007049">
        <property type="term" value="P:cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005286">
        <property type="entry name" value="Cell_div_FtsE_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02673">
        <property type="entry name" value="FtsE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="6 8" id="KW-0132">Cell division</keyword>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 5 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="7">
        <location>
            <begin position="2"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="36"/>
            <end position="43"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00020019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU365094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PJN10524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="229" mass="25729" checksum="19D3BA62D401E597" modified="2018-04-25" version="1">MIRFDNVSKAYPKQTRPALRDVSLEVERGEFVFLVGSSGSGKSTFLRLILREERTSHGQVHVLGKDLARLSNWKVPQMRRQLGTVFQDFRLLPNKTVGENVAFAQEVIGKSRGEIRKSVPQVLDLVGLGGKEDRMPGELSGGEQQRVAIARAFVNRPKLLIADEPTGNLDPQTSVGIMKLLDRINRTGTTVVMATHDQQIVDQMRKRVIELEKGRLVRDQSRGVYGYQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JUK5</accession>
    <name>A0A2M9JUK5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">4-hydroxyphenylpyruvate dioxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">hppD</name>
        <name evidence="7" type="ORF">CG723_15260</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CB01635</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
        <text evidence="5">Binds 1 Fe cation per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the 4HPPD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000004">
        <property type="protein sequence ID" value="PJN10576.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN10576">
        <property type="protein sequence ID" value="PJN10576"/>
        <property type="gene ID" value="CG723_15260"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003868">
        <property type="term" value="F:4-hydroxyphenylpyruvate dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009072">
        <property type="term" value="P:aromatic amino acid family metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07250">
        <property type="entry name" value="HPPD_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd08342">
        <property type="entry name" value="HPPD_N_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005956">
        <property type="entry name" value="4OHPhenylPyrv_dOase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041735">
        <property type="entry name" value="4OHPhenylPyrv_dOase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041736">
        <property type="entry name" value="4OHPhenylPyrv_dOase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004360">
        <property type="entry name" value="Glyas_Fos-R_dOase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11959">
        <property type="entry name" value="PTHR11959"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00903">
        <property type="entry name" value="Glyoxalase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF009283">
        <property type="entry name" value="HPP_dOase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01263">
        <property type="entry name" value="4HPPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="4 5" id="KW-0408">Iron</keyword>
    <keyword evidence="2 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="VOC" evidence="6">
        <location>
            <begin position="25"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="domain" description="VOC" evidence="6">
        <location>
            <begin position="187"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="190"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="273"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="352"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005877"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR009283-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PJN10576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="384" mass="42100" checksum="0633ED2816B91759" modified="2018-04-25" version="1">MAATSANIQTTPDTAREADPFPVKGMDAVVFAVGNAKQAAHYYSTAFGMKLVAYSGPENGSRETASYVLTNGSARFVFTSVIKVSTDWGQFLADHVAEHGDGVVDLAIEVPDARAAYAYAVEHGARGITEPYESKDEHGTVVRAAIATYGKTRHTLVERTGYDGPYLPGFAAAEPVVAPPAKRTFQAIDHCVGNVELGRMNEWVAFYNKVMGFTNMKEFVGDDIATEYSALMSKVVADGTLKVKFPINEPAIAKKKSQIDEYLEFYGGAGVQHIALATNDIVESVRTMRAAGVQFLDTPDSYYDTLGEWAGETRVPVETLREQKILVDRDEDGYLLQIFTKPVQDKPTVFFEMIERHGSMGFGKGNFKALFEAIEREQDKRGNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JUS3</accession>
    <name>A0A2M9JUS3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CG723_15470</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CB01635</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000004">
        <property type="protein sequence ID" value="PJN10613.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN10613">
        <property type="protein sequence ID" value="PJN10613"/>
        <property type="gene ID" value="CG723_15470"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="31"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="67"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="99"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="125"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="158"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="187"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="248"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="282"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="317"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="341"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="374"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="406"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="7">
        <location>
            <begin position="33"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="433"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="443"/>
            <end position="457"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PJN10613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="457" mass="47153" checksum="5F4A509E1D98FCD0" modified="2018-04-25" version="1">MSWPSGQSWRRVPPSQGEVMRPYRKIPRSPWTVAAGAALAIVTAGAFSTLAGLLVGPLHEDLGWSRASIGLGSLVNMVVYGASAPFAAALMDRLGMRRVAVGALCLVGAGAGLATTMTAPWQFVLYWGVLVGLGTGATATTFAATVTERWFVARRGLVTGLLTAASVVGQFVFLPVLSWVIDTYSWRAAAAALALAAAGALPVVWAAVREPRKDPGRTEDTARPAGRTEGAARHALRTLARAARTGPFWLLAGTFAVCGASTNGVMWTHFAPAAHDHGMPVTVAASLLSLIGIFNVAGTVASGWLTDRADPRRLLAVYYALRGLTLLALPLLLTSAVDAPLVAFTVVFGLLDVATVPPTIALCRAHYGAGAPVVFGWVSAAHQVGAGAVAFAGGMARDTFGSYDPVWVGAGALCAGAALLALTVRRSGQAGRAALTPPVPATPRRSRALPASPPPCR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JUW4</accession>
    <name>A0A2M9JUW4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">GntR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CG723_15730</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000004">
        <property type="protein sequence ID" value="PJN10659.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN10659">
        <property type="protein sequence ID" value="PJN10659"/>
        <property type="gene ID" value="CG723_15730"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07377">
        <property type="entry name" value="WHTH_GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.530">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011711">
        <property type="entry name" value="GntR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008920">
        <property type="entry name" value="TF_FadR/GntR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07729">
        <property type="entry name" value="FCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
        <property type="entry name" value="GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00035">
        <property type="entry name" value="HTHGNTR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00895">
        <property type="entry name" value="FCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00345">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48008">
        <property type="entry name" value="SSF48008"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50949">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH gntR-type" evidence="4">
        <location>
            <begin position="1"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PJN10659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="236" mass="25877" checksum="7D71D3198E583527" modified="2018-04-25" version="1">MARDLQERIKKLIIDRRLPSGASLPTEPELMELLGVSRNSVREALKALQAMGIVEIRHGFGTYVGPMSMAPMIEGLTFRTVAGHYRGEDSLLQLLELREAVETGLIARLAGRVPDADLAELDALVDRMDTEAAADGAVSPGTDRAFHATLYRGLGNPLLGEVMEAFWDAFHRVRTDLVAIPHDPKVTGLQHREIVDAVRSGDPLRAERAIREHFGDIRARLSTPADTRGERPASST</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JV94</accession>
    <name>A0A2M9JV94_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Aminopeptidase N</fullName>
            <ecNumber evidence="4">3.4.11.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Alanine aminopeptidase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">Lysyl aminopeptidase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="primary">pepN</name>
        <name evidence="16" type="ORF">CG723_16655</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">CB01635</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Release of an N-terminal amino acid, Xaa-|-Yaa- from a peptide, amide or arylamide. Xaa is preferably Ala, but may be most amino acids including Pro (slow action). When a terminal hydrophobic residue is followed by a prolyl residue, the two may be released as an intact Xaa-Pro dipeptide.</text>
            <dbReference type="EC" id="3.4.11.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the peptidase M1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.11.2" evidence="4"/>
    <dbReference type="EMBL" id="NNBL01000004">
        <property type="protein sequence ID" value="PJN10806.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN10806">
        <property type="protein sequence ID" value="PJN10806"/>
        <property type="gene ID" value="CG723_16655"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1730">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045357">
        <property type="entry name" value="Aminopeptidase_N-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042097">
        <property type="entry name" value="Aminopeptidase_N-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024571">
        <property type="entry name" value="ERAP1-like_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012778">
        <property type="entry name" value="Pept_M1_aminopeptidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001930">
        <property type="entry name" value="Peptidase_M1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014782">
        <property type="entry name" value="Peptidase_M1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027268">
        <property type="entry name" value="Peptidase_M4/M1_CTD_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11838">
        <property type="entry name" value="ERAP1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01433">
        <property type="entry name" value="Peptidase_M1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17900">
        <property type="entry name" value="Peptidase_M1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00756">
        <property type="entry name" value="ALADIPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63737">
        <property type="entry name" value="SSF63737"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02412">
        <property type="entry name" value="pepN_strep_liv"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="16" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="6" id="KW-0645">Protease</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase_M1_N" evidence="15">
        <location>
            <begin position="120"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M1" evidence="13">
        <location>
            <begin position="242"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="domain" description="ERAP1_C" evidence="14">
        <location>
            <begin position="536"/>
            <end position="847"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012564"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00015611"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00029811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00031533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF01433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF11838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF17900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="PJN10806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="860" mass="95323" checksum="D6C26CA621C37E85" modified="2018-04-25" version="1">MPGENLSRDEARERAGLLSVDGYEVQLDLRSAIGETEGEGPRTFRSVTTIRFRATEPGAATFVDLIAPSVNAVTLNGEDLDTAAVFDGTRIALDGLAAENELVVDAQCAYSRTGEGMHRFVDPEDGEVYLYTQYEPADSRRVYAGFEQPDLKAPYRFSVQAPEGWTVWSNGVGELADDVWKFAETKPISTYITAIVAGPYHYVTDSYERVFEDGTKLEIPLGAMCRKGLAKHFDADDVFLVTKQGLDFFHDHFDYPYPFGKYDQAFVPEYNLGAMENPGCVTFREEFIFRGKVTQASYERRANVILHEMAHMWFGDLVTMQWWDDLWLKESFADFMGTFSMVEATRFANGWITFANNRKAWAYRADQLPSTHPVTADIRDLEDAKLNFDGITYAKGASVLKQLVAYVGREAFLEGARRYFKRNAYGNTQLGDLLSVLEETSGRDMATWSRAWLQTAGVNSLTPQVTLSAEGRITELAVIQEAADSHPTLRPHRVAVGLYHRDGASGALVRYARAEVDVDGPRTVLDELAGAEAPELVLVNDDDLTYCKIRFDENSLATLREHLGDITDPLARALCWSALWSLTRDGLMPARDFIGLVLRFAGRESDIGVLQMLHTWANSAVTHYAAPEWRAEGSRQLAEGALRELRFAEPASQNQLTWARFFASVASAEADLQLLRGLLQGTAKIDGLDVDQELRWSFVNALASTGEADESVIDAELARDDTASGKRHQVRCLAARPSAAVKAQAWAQVVESDALSNALVEATIAGFQQPAQRELTAPYAERYFAAIERVWQERSIQIGMDVVKGLFPSLQDSQGTLDATDAWLAAHEDAAPALRRLVLEARDDLARALRAQACDATAGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JVE2</accession>
    <name>A0A2M9JVE2_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Leucine--tRNA ligase</fullName>
            <ecNumber evidence="9">6.1.1.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Leucyl-tRNA synthetase</fullName>
            <shortName evidence="9">LeuRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">leuS</name>
        <name evidence="14" type="ORF">CG723_16980</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">CB01635</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu)</text>
            <dbReference type="Rhea" id="RHEA:11688"/>
            <dbReference type="Rhea" id="RHEA-COMP:9613"/>
            <dbReference type="Rhea" id="RHEA-COMP:9622"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57427"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78494"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.4"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9 10">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.4" evidence="9"/>
    <dbReference type="EMBL" id="NNBL01000004">
        <property type="protein sequence ID" value="PJN10861.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN10861">
        <property type="protein sequence ID" value="PJN10861"/>
        <property type="gene ID" value="CG723_16980"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002161">
        <property type="term" value="F:aminoacyl-tRNA editing activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004823">
        <property type="term" value="F:leucine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006429">
        <property type="term" value="P:leucyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00049_B">
        <property type="entry name" value="Leu_tRNA_synth_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002302">
        <property type="entry name" value="Leu-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025709">
        <property type="entry name" value="Leu_tRNA-synth_edit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013155">
        <property type="entry name" value="M/V/L/I-tRNA-synth_anticd-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015413">
        <property type="entry name" value="Methionyl/Leucyl_tRNA_Synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009008">
        <property type="entry name" value="Val/Leu/Ile-tRNA-synth_edit"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43740">
        <property type="entry name" value="PTHR43740"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08264">
        <property type="entry name" value="Anticodon_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13603">
        <property type="entry name" value="tRNA-synt_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09334">
        <property type="entry name" value="tRNA-synt_1g"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00985">
        <property type="entry name" value="TRNASYNTHLEU"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="SSF47323"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50677">
        <property type="entry name" value="SSF50677"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00396">
        <property type="entry name" value="leuS_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9 10" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="6 9 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 9 10" id="KW-0436">Ligase</keyword>
    <keyword evidence="5 9 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 9 10" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="tRNA-synt_1g" evidence="12">
        <location>
            <begin position="70"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="domain" description="tRNA-synt_1_2" evidence="13">
        <location>
            <begin position="300"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="domain" description="Anticodon_1" evidence="11">
        <location>
            <begin position="813"/>
            <end position="925"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'KMSKS' region" evidence="9">
        <location>
            <begin position="732"/>
            <end position="736"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="735"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU363039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF08264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF09334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF13603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="PJN10861.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="964" mass="107260" checksum="E92C621CE76A9828" modified="2018-04-25" version="1">MSETNSAAASEVAAPHRYTAAMAADIEARWQDFWDADGTYEAPNPSGDLAGDTEAGRAMAARPKKFVMDMFPYPSGAGLHVGHPLGYIATDVFARFQRMNGHNVLHTLGFDAFGLPAEQYAVQTGTHPRTSTEANMVNMKSQLRRLGLGHDKRRSFATIDPEYYKWTQWIFVQIFNSWYDDEAKKARPIDQLIAQFESGERAVPDSTRAWHELNAAERADVLSEYRLAYASEAPVNWCPGLGTVLANEEVTADGRSERGNYPVFKAKLRQWNMRITAYADRLLDDLDALDWPEAIKLQQRNWIGRSEGARVDFPVGDEAITVFTTRQDTLFGATYMVLAPEHDLVDRIVPAAWPEGTHDVWTGGHATPAEAVAAYRKQAASKSDVERQAEAKDKTGVFTGAYAANPVSGEQVPVFIADYVLMGYGTGAIMAVPAHDTRDFAFARAFELPMRCVVEPSDDRGTDTSTWDDAFASYDARLVNSASDQISVDGMGVTDAKARMTEWLERTGIGRGTVNFRLRDWLFSRQRYWGEPFPIVYDEDGVAHSLPESMLPLELPEVDDYSPRTFDADDADTRPETPLSRNDDWVHVTLDLGDGPKKYRRETNTMPNWAGSCWYELRYLDPHNSDKLVDPAIEQYWMGPREGQPTGGVDLYVGGAEHAVLHLLYARFWSKMLFDLGHISSAEPFHKLYNQGMIQAYVYRDSRGIAVPAAEVEERDGAYYFEGEKVSRLLGKMGKSLKNAVTPDEICAEYGADTLRLYEMAMGPLDVSRPWDTRAVVGQFRLLQRLWRNIVDEASGEVTVVDTEDSAIDGITLRALHKAIDGVRQDLEGMRFNTAIAKVTELNNHLTKVGGPLSRSVAERLVLLVAPLAPHIAEELWRKLGHTDSVVHQDFPVADPAYVVDESVTCVVQIKGKVKARLEVSPSISDEELEKVALADERVVAALDGAGIRKVIVRAPKLVNIVPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-05-25" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JVX4</accession>
    <name>A0A2M9JVX4_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 8">DNA repair protein RecO</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7 8">Recombination protein O</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">recO</name>
        <name evidence="10" type="ORF">CG723_17255</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CB01635</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 8">Involved in DNA repair and RecF pathway recombination.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the RecO family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000004">
        <property type="protein sequence ID" value="PJN10907.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN10907">
        <property type="protein sequence ID" value="PJN10907"/>
        <property type="gene ID" value="CG723_17255"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1440.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00201">
        <property type="entry name" value="RecO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037278">
        <property type="entry name" value="ARFGAP/RecO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022572">
        <property type="entry name" value="DNA_rep/recomb_RecO_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003717">
        <property type="entry name" value="RecO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042242">
        <property type="entry name" value="RecO_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33991">
        <property type="entry name" value="PTHR33991"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02565">
        <property type="entry name" value="RecO_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11967">
        <property type="entry name" value="RecO_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57863">
        <property type="entry name" value="SSF57863"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00613">
        <property type="entry name" value="reco"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0227">DNA damage</keyword>
    <keyword evidence="5 8" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="6 8" id="KW-0234">DNA repair</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA_rep/recomb_RecO_N" evidence="9">
        <location>
            <begin position="1"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00033409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF11967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PJN10907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="249" mass="27060" checksum="06614D8D924378D8" modified="2018-04-25" version="1">MSLFRDDGIVLRTQKLGEADRIITLLTRNHGRVRAVARGVRRTKSKFGARLEPFSHVDVQFFARGSELIGRGLPLCTQSETIAPYGGGIVSDYARYTAGTAMLETAERFTDHEGEPAVQQYLLLVGGLRTLSRGEHEPHLVLDAFLLRSLAVNGYAPSFGDCAKCGLPGPNRFFSVGAGGSVCVDCRVPGSVVPSPQALILLGALLTGDWETADACEARFVREGSGLVSAYLHWHLERGLRSLRYVEKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JW04</accession>
    <name>A0A2M9JW04_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Anti-sigma factor antagonist</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CG723_08625</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CB01635</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the anti-sigma-factor antagonist family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN11039.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN11039">
        <property type="protein sequence ID" value="PJN11039"/>
        <property type="gene ID" value="CG723_08625"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043856">
        <property type="term" value="F:anti-sigma factor antagonist activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.750.24">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003658">
        <property type="entry name" value="Anti-sigma_ant"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002645">
        <property type="entry name" value="STAS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036513">
        <property type="entry name" value="STAS_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01740">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52091">
        <property type="entry name" value="SSF52091"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00377">
        <property type="entry name" value="ant_ant_sig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50801">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="STAS" evidence="3">
        <location>
            <begin position="11"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PJN11039.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="135" mass="14722" checksum="6D9C43D8A52768CD" modified="2018-04-25" version="1">MCDQGVAGPHESVDCHVANGWTVVEANEEIDIAFAPFVQAAVVRRLAEGHRHFVLDLCSTPFLDSMGLGMIVAVTKRIKSCHGSLRIACSDKWLLHVFSLGGLRHVYSFHDSVEQAIAQSPGASSWPVRSVTRHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JW09</accession>
    <name>A0A2M9JW09_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HTH_21 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_08650</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN11044.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN11044">
        <property type="protein sequence ID" value="PJN11044"/>
        <property type="gene ID" value="CG723_08650"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025948">
        <property type="entry name" value="HTH-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13276">
        <property type="entry name" value="HTH_21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH_21" evidence="1">
        <location>
            <begin position="40"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN11044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="96" mass="10474" checksum="56E524F53A677A5D" modified="2018-04-25" version="1">MAGEGLPVRTATRALGVTESGYFTWRARRPSARSIRHTWLTELITTIHAASGATHGYRRIHSELTRTYGIAVSHGTVELLMRRAGIQGRTGDGTPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JW72</accession>
    <name>A0A2M9JW72_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_09105</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN11114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN11114">
        <property type="protein sequence ID" value="PJN11114"/>
        <property type="gene ID" value="CG723_09105"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045961">
        <property type="entry name" value="DUF6381"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19908">
        <property type="entry name" value="DUF6381"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="26"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN11114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="62" mass="6910" checksum="DF4C41EEFB5B5743" modified="2018-04-25" version="1">MSVAGESGDRAQQMRAQVQKIEQAAERASDPAERQRLKDKARRIEEQSKKESEPGRGGVDPM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JWQ9</accession>
    <name>A0A2M9JWQ9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Enoyl-CoA hydratase</fullName>
            <ecNumber evidence="3">4.2.1.17</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_10000</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the enoyl-CoA hydratase/isomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.17" evidence="3"/>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN11258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN11258">
        <property type="protein sequence ID" value="PJN11258"/>
        <property type="gene ID" value="CG723_10000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004300">
        <property type="term" value="F:enoyl-CoA hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018376">
        <property type="entry name" value="Enoyl-CoA_hyd/isom_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00166">
        <property type="entry name" value="ENOYL_COA_HYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN11258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="254" mass="26632" checksum="D326B11EA457AD2E" modified="2018-04-25" version="1">MPVRVERRGHVTTVVLSRPEVRNAVDGPTAAELAAAFKEFDADESARVAVLWGEGGTFCAGADLKAIGTERGNRVAEEGDGPMGPTRLRLSKPVIAAVSGHAVAGGLELALWCDLRVAEEDAVFGVFCRRWGVPLIDGGTVRLPRLIGESRAMDLILTGRPVPAPEAYAMGLANRLVPPGRARAEAEELAEQIAGFPQACMRGDRASVLDQAGQGEEAAMAGELRYGTAVLEESLTGAARFASGAGRHGSFTDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JWY3</accession>
    <name>A0A2M9JWY3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">GntR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CG723_10800</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN11400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN11400">
        <property type="protein sequence ID" value="PJN11400"/>
        <property type="gene ID" value="CG723_10800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07377">
        <property type="entry name" value="WHTH_GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.530">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011711">
        <property type="entry name" value="GntR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008920">
        <property type="entry name" value="TF_FadR/GntR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07729">
        <property type="entry name" value="FCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
        <property type="entry name" value="GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00035">
        <property type="entry name" value="HTHGNTR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00895">
        <property type="entry name" value="FCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00345">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48008">
        <property type="entry name" value="SSF48008"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50949">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH gntR-type" evidence="4">
        <location>
            <begin position="17"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PJN11400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="253" mass="27131" checksum="D9D5131C6AD1A51E" modified="2018-04-25" version="1">MSNSESRDEWTAGTRQAASHAVVAEALRQRIALGGFGPGDRLPTERELSAVFGVGRNTVRQAVRELAEEGLVTTTLGRNGGTRVAPTPPGGEGSRAAITATIRASLRDYMEYRLAIEPYAARLAAERGAGAARRELVAMLENQVADLGEYHRCDTAFHLGIAAAGGNEVLAEAVTRARAEMFVGGNALWLGSDWSRVYPAERDFGSAFREEHEAIALAVLSGDGAAAEARMRDHLLDSHRQFLALLDQFAAQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JWZ6</accession>
    <name>A0A2M9JWZ6_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 4">Diaminopimelate decarboxylase</fullName>
            <shortName evidence="3">DAP decarboxylase</shortName>
            <shortName evidence="3">DAPDC</shortName>
            <ecNumber evidence="3 4">4.1.1.20</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3 7" type="primary">lysA</name>
        <name evidence="7" type="ORF">CG723_10930</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CB01635</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Specifically catalyzes the decarboxylation of meso-diaminopimelate (meso-DAP) to L-lysine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3 4">
            <text>H(+) + meso-2,6-diaminoheptanedioate = CO2 + L-lysine</text>
            <dbReference type="Rhea" id="RHEA:15101"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:32551"/>
            <dbReference type="ChEBI" id="CHEBI:57791"/>
            <dbReference type="EC" id="4.1.1.20"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 3 4">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 4">Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; L-lysine from DL-2,6-diaminopimelate: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the Orn/Lys/Arg decarboxylase class-II family. LysA subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.20" evidence="3 4"/>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN11421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN11421">
        <property type="protein sequence ID" value="PJN11421"/>
        <property type="gene ID" value="CG723_10930"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00034">
        <property type="reaction ID" value="UER00027"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008836">
        <property type="term" value="F:diaminopimelate decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009089">
        <property type="term" value="P:lysine biosynthetic process via diaminopimelate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06828">
        <property type="entry name" value="PLPDE_III_DapDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.37.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02120">
        <property type="entry name" value="LysA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009006">
        <property type="entry name" value="Ala_racemase/Decarboxylase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002986">
        <property type="entry name" value="DAP_deCOOHase_LysA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022643">
        <property type="entry name" value="De-COase2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022644">
        <property type="entry name" value="De-COase2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022653">
        <property type="entry name" value="De-COase2_pyr-phos_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000183">
        <property type="entry name" value="Orn/DAP/Arg_de-COase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029066">
        <property type="entry name" value="PLP-binding_barrel"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02784">
        <property type="entry name" value="Orn_Arg_deC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00278">
        <property type="entry name" value="Orn_DAP_Arg_deC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01181">
        <property type="entry name" value="DAPDCRBXLASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01179">
        <property type="entry name" value="ODADCRBXLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50621">
        <property type="entry name" value="SSF50621"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51419">
        <property type="entry name" value="SSF51419"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01048">
        <property type="entry name" value="lysA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00878">
        <property type="entry name" value="ODR_DC_2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="3 4" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="3 4" id="KW-0456">Lyase</keyword>
    <keyword evidence="2 3 4" id="KW-0457">Lysine biosynthesis</keyword>
    <keyword evidence="3" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Orn_Arg_deC_N" evidence="6">
        <location>
            <begin position="56"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="domain" description="Orn_DAP_Arg_deC" evidence="5">
        <location>
            <begin position="309"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="region of interest" description="Pyridoxal phosphate binding" evidence="3">
        <location>
            <begin position="302"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="260"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="305"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="341"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="345"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="373"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="402"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="3">
        <location>
            <position position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02784"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PJN11421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="445" mass="47144" checksum="4F7FC67379A2CDD5" modified="2018-04-25" version="1">MTTVHEPAVTTATADELSVWPASTTEPHPGDLAVGGVPLAGVADRFGTPAYVLDEGEVRERCRTYRHAFPDAEVLYAAKAFLCRAMAHWVDDEGLGLDVCSAGELELAVTTGFPPERIVLHGNAKSPHDLESALRLGVGRIVIDSPSEIARLAAAVGPDGHQKVMVRVVPAISAGGHEKIRTGTDDQKFGLSISDGYAQHAIARILDQPQLELTGLHCHLGSQITSVKPYLAAVRRMVGLMARLHEQHGLVLPELDLGGGHGIAYRPGEQALDITTLARKVRAELTEACAAAGLTVPRLIIEPGRAIAGPAGIALYRVLAVKRTGAHTFVAVDGGMSDNPRPALYGVRYAPRLIGRHSTADRTAMTVVGRHCEAGDVLATDVELPADVHPGDLLAVPVAGAYHLSMASGYNLVGRPPVVAVDDGRARLLVRRESLDDIRSRDVGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JX03</accession>
    <name>A0A2M9JX03_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CG723_10945</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN11424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN11424">
        <property type="protein sequence ID" value="PJN11424"/>
        <property type="gene ID" value="CG723_10945"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006764">
        <property type="entry name" value="SAM_dep_MeTrfase_SAV2177_type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04672">
        <property type="entry name" value="Methyltransf_19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017393">
        <property type="entry name" value="MTase_SAV2177"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PJN11424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="261" mass="29021" checksum="BADA23627E55B501" modified="2018-04-25" version="1">MTAQSSGSRIDTSRAHPARVYDWLLGGKDNYPVDQEVGEKLPPESRLSARRNRAFMHRAAAWLAGNGIDQFLDVGTGIPTKPNLHQIVQGIVPSARVAYTDNDPIVLRHAEALLVSTPEGATDYIEADVRQPKVILDHARTFLDFTRPVALSMLALMHFITDEEDPYALARTLIDALPSGSYFVFSHGTTDEHPHLAKTVKNTYRQGEIPLRMRTRAEVEPFFESLELVEPGLVTSTKWYKETPAPEAELSGFYVGVARVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JX66</accession>
    <name>A0A2M9JX66_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Pyridine nucleotide-disulfide oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CG723_10480</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CB01635</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="2">Binds 1 FAD per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN11347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN11347">
        <property type="protein sequence ID" value="PJN11347"/>
        <property type="gene ID" value="CG723_10480"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045454">
        <property type="term" value="P:cell redox homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016156">
        <property type="entry name" value="FAD/NAD-linked_Rdtase_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001100">
        <property type="entry name" value="Pyr_nuc-diS_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004099">
        <property type="entry name" value="Pyr_nucl-diS_OxRdtase_dimer"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02852">
        <property type="entry name" value="Pyr_redox_dim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000350">
        <property type="entry name" value="Mercury_reductase_MerA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55424">
        <property type="entry name" value="SSF55424"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="2" id="KW-0520">NAD</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyr_redox_2" evidence="5">
        <location>
            <begin position="7"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="domain" description="Pyr_redox_dim" evidence="4">
        <location>
            <begin position="359"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="53"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="116"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="183"/>
            <end position="190"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="270"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="310"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="disulfide bond" description="Redox-active" evidence="3">
        <location>
            <begin position="44"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000350-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000350-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PJN11347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="474" mass="49651" checksum="1A45C306AFBFEA22" modified="2018-04-25" version="1">MTDENTYDVVVLGAGPVGENVADRARAAGLSTAVVESELVGGECSYWACMPSKALLRPVIAQADARRLPGLLESVQGPLDAPAVLARRDEYTSHWKDDGQVSWLESIGADLYRGQGRLAGPRRVTVTGPDGTEHVLTARHAVAVCTGTRAALPDLPGLADVEPWTSREATSAQKVPGRLVVVGGGVVAAEMATAWQALGSQVTMLVRGSGLLSRMEPFAGELVAQALAEAGAEVRTGVSVKGVTREGGTVVTTLDDGSTLESDEILFATGRAPRTEDIGLETVGLEPGSWLPVDDSLRVDGSTWLYAVGDVNHRALLTHQGKYQARIAGAAIAARAQGVPLLETDRWGAHAATADHSAVPQVVFTDPEAGSAGLTLAEAEAAGHRVRAVDYDIASVAGAGLYGDGYRGRARMIVDLDREILLGVTFVGPGVGELIHSATVAVAGEVPIDRLWHAVPSYPTVSEVWLRLLETYRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JY68</accession>
    <name>A0A2M9JY68_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_13295</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN11814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN11814">
        <property type="protein sequence ID" value="PJN11814"/>
        <property type="gene ID" value="CG723_13295"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="25"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="47"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="58"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="93"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN11814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="168" mass="17275" checksum="12E55D8346DDB166" modified="2018-04-25" version="1">MTNSYTTPPAPRPVDTRPLRKRKRVWLGGSGLLLTGALIVGAGNGDQQPVAAEAKPAPTVTTTVTATPEPAPTVTETIKAKAKPRPTVTVTKTARAAADTGSDTGSDTGSGSGSQDTTGTCSITSNAGNCYSAGQFCRNSDHGAVTTNEGGTRIKCVYSSNAWRWTYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JYE3</accession>
    <name>A0A2M9JYE3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_13845</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN11903.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN11903">
        <property type="protein sequence ID" value="PJN11903"/>
        <property type="gene ID" value="CG723_13845"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN11903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="383" mass="42470" checksum="09A9AC58A457C332" modified="2018-04-25" version="1">MAKNSSSSTIAPDTAWLGRGRHLGPEPEQDVRRNLIALKAAGVLDDFLDLDPVEAARSTALHPRDESADPGPTARRLFEARWRVADDVTVRAQLTTYDPEARRKEGEGVTWVLAAEAQRAWDAHWPSPATMFWPDSDRVDWDHDTVPGVRLRAANYLPKDDDELRHRLRDCTRNSWFIHVVVHEAMTPDAMGQKPVSAFLPPSLRHRVVEHRGTPDQAQIADVAMKRELSLRMPRGGAVVLPTVPPVPGYEAERFTVRSVFLDGSEPTELLDRIREFAALPRSMPDDAERALTRLRQGWHLLTPDEELVHAQGMVVRYAEALEAMTKSCDLYREAAEAAQAALAEATGGAGVPRPVDPGSARLDGSPLTAFTKAFGRFRGPNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JYH3</accession>
    <name>A0A2M9JYH3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Sugar ABC transporter substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_14005</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN11930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN11930">
        <property type="protein sequence ID" value="PJN11930"/>
        <property type="gene ID" value="CG723_14005"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006059">
        <property type="entry name" value="SBP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01547">
        <property type="entry name" value="SBP_bac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014876965" evidence="1">
        <location>
            <begin position="37"/>
            <end position="444"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN11930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="444" mass="48277" checksum="CE4DCAC6C64B3AA7" modified="2018-04-25" version="1">MPEPRSGRRPLPRRAVLAAAAVGLSPALNSTLTACATASGSTSGGVTLTFSWWGNDDRAARTEQAVRLFEKEHPGVTVRTSSGDFGAYLQKLATQAAGGGMPDVAQLDYRQVSQYAGGGALMSLDDAIKNGTIRTSDMSRDFLRTGTYKGGQYALPMGRGITGYAYDSAVYEKANIPSPKPSWTWQDWERANRKIVALGLKSPDGRPFAGANDGGTNEDVFETWLRSRGGKLYASQTELGFTEDDLTAFWTFCDRLRKDGTIAQARDTAQANSTETSPMGRHLAAADFTWDAPFPSYPALLGDSVHFAPVPTTDGHQGSYFKPSMLIGVSADSEHPEEAAQLVDFLLNDQRVGDILAFSRSTPPNRRIAARVAKTLKGPEREIYEYAQTLEKYGLDAPPTAPPRGDVAIQTAFTREYQRVMYGLATPRQAARELIDEANRELRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JYY8</accession>
    <name>A0A2M9JYY8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Short-chain dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_14915</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN12081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN12081">
        <property type="protein sequence ID" value="PJN12081"/>
        <property type="gene ID" value="CG723_14915"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN12081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="239" mass="24575" checksum="D9A2E2CBCD4D8B2B" modified="2018-04-25" version="1">MKIDGSVAFVTGANRGLGEQFVRALFEAGAAKVYAGARDPAKVTVPGAVPVTVDITDHESVRAAGAQAQDVTLLINNAGSTTRAGILTSDLDSFRTEFETHVLGTLAMSRAFAPVLERNGGGALVNVLSVLSWVSIPVSAGYAAAKSAEWSVTNALRVALAEQGTQVTALHVSYLATDMAANVRGPKADPGEVARAALAGVEAGRHEVLADEVSKQVQAALPGGPHELYPQLHGGQSLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JZG5</accession>
    <name>A0A2M9JZG5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">FAD-dependent oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_04205</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000002">
        <property type="protein sequence ID" value="PJN12272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN12272">
        <property type="protein sequence ID" value="PJN12272"/>
        <property type="gene ID" value="CG723_04205"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016156">
        <property type="entry name" value="FAD/NAD-linked_Rdtase_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028202">
        <property type="entry name" value="Reductase_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14759">
        <property type="entry name" value="Reductase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55424">
        <property type="entry name" value="SSF55424"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyr_redox_2" evidence="1">
        <location>
            <begin position="8"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="domain" description="Reductase_C" evidence="2">
        <location>
            <begin position="333"/>
            <end position="419"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN12272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="424" mass="45227" checksum="CF49AC3DC7CEA112" modified="2018-04-25" version="1">MVDADQTFVIVGGGLAGAKAAETLRSEGFNGRVILIGDERDHPYERPPLSKGYLQGKEERDSVFVHEPAWYAQNDIELHLGQTVVAVDPAVKNVRLGDGTVVHYDKLLLVTGAEPRRMDIPGTELAGVHHLRRLAHAERLKGVLASLGRDNGHIVIAGAGWIGLEVAAAAREYGAEVTVVEPEATPLHAVLGPEIGQIFADLHAEHGVRFHFGTRLTGITGQDGMVLAALTDDGEEHLAHDVLAAIGAAPRVSLAESAGIELADRSHGGGIAVDASLRTSDPDIYAAGDVAAVQHPLFGTRLRVEHWANALNGGPAAARAMLGQEVTYDRVPYFFSDQYDVGLEYSGWAPPGSYDQVVIRGDAGKRQFIAFWLKDGRVLAGMNVNVWDVTETIQALIRSGVRPGAERLSDPSVALTALLEGEDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JZI8</accession>
    <name>A0A2M9JZI8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Nitrite reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CG723_04180</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000002">
        <property type="protein sequence ID" value="PJN12268.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN12268">
        <property type="protein sequence ID" value="PJN12268"/>
        <property type="gene ID" value="CG723_04180"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043546">
        <property type="term" value="F:molybdopterin cofactor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009010">
        <property type="entry name" value="Asp_de-COase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006657">
        <property type="entry name" value="MoPterin_dinucl-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006656">
        <property type="entry name" value="Mopterin_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006963">
        <property type="entry name" value="Mopterin_OxRdtase_4Fe-4S_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04879">
        <property type="entry name" value="Molybdop_Fe4S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00384">
        <property type="entry name" value="Molybdopterin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01568">
        <property type="entry name" value="Molydop_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00926">
        <property type="entry name" value="Molybdop_Fe4S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50692">
        <property type="entry name" value="SSF50692"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51669">
        <property type="entry name" value="4FE4S_MOW_BIS_MGD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="2 4" id="KW-0408">Iron</keyword>
    <keyword evidence="3 4" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="1 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4Fe-4S Mo/W bis-MGD-type" evidence="5">
        <location>
            <begin position="2"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="9"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="12"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="16"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="44"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PJN12268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="703" mass="74621" checksum="5C14ECE00BFF09E4" modified="2018-04-25" version="1">MLTVTPTHCPYCSLQCGMNLVPTASGVVEVAERAGFPVNRGALCGKGRTAAAVLEPGVRLSGPLVRKGGALEAASWGEALDRVAEGLSRTRSAHGPDACGVFGGGGLTNEKAYGLGKFARVVLGTSQIDYNGRFCMSSAAAGQLAAFGLDRGLPFPLEDIPRTGCVVLVGSNMAETMPPAVRYLNELRENGGTLVVIDPRRTRTAELADLHLAPRPGTDLALALGMLHLVVTEGRVDEEFVRARTRGWEDARAAVMAHWPEYVERVTGVPVPQLREAVRMFCEPEAAMVLTARGPEQQSKGTDTVGAWINLCLATGRAGRPLSGYGCLTGQGNGQGGREHGQKADQLPGYRKLTDPAARAHVAGVWGVDPDSLPGPGRSAYELLDALGRDVRALLVMGSNPVVSAPRAAHVEGRLRSLDFLAVADVVLSETAALADVVLPVTQWAEETGTVTSLEGRVLLRRRAISPPDGVRSDLEVLRELAGRLGVEKGFPADPEEVFEELRLASEGGPADYAGISYRRLVEEDGVFWPCPEEEHPGTPRLFLERFATDDGRARFVAVSHRAAAEEPDAEFPVHLTTGRVVSQYQSGAQTRRVAELNAAAPGPFVELHPRLAALIGVAEGEPVAVVSRRGRAEAPARITAGIRPDTVFMPFHWPGAGRANNLTNPALDPTSRMPEFKVCAVRVEAAGIDSGSGDRSDGVVHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JZJ7</accession>
    <name>A0A2M9JZJ7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CG723_04260</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000002">
        <property type="protein sequence ID" value="PJN12278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN12278">
        <property type="protein sequence ID" value="PJN12278"/>
        <property type="gene ID" value="CG723_04260"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PJN12278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="78" mass="8111" checksum="7502AEDB394D91F4" modified="2018-04-25" version="1">MPGSSGSIEPSKSRRLSSVMLHIPYTDGGIRNGVMADQPRIAMGGMPAVHGLGIHQAADCLAPSIRDVESAPSDLRDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-09-29" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JZR9</accession>
    <name>A0A2M9JZR9_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Acyl_transf_3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_04550</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000002">
        <property type="protein sequence ID" value="PJN12330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN12330">
        <property type="protein sequence ID" value="PJN12330"/>
        <property type="gene ID" value="CG723_04550"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002656">
        <property type="entry name" value="Acyl_transf_3_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01757">
        <property type="entry name" value="Acyl_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="30"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="68"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="112"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="146"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="174"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="204"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="234"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="274"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="302"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="350"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="388"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl_transf_3" evidence="2">
        <location>
            <begin position="24"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN12330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="405" mass="43004" checksum="F1DB8A7B41CF81A9" modified="2018-04-25" version="1">MSIATLRRTASAIDAKTPAHRDRAIDGLRALALLAVPMGHWLLGGFSLDGQGALHNTSPLSSFGFLAPISWVLQMLGIFFLVGGYASVLSYRRTLEAGGSMSVWLRGRLARLGRPVLGVTAVCAALIPALYALGVPEKTLHTGSTLVIQPLWFVGVYTVITALTPYCVRAARKLGAWAAAPLLGSVAVIDFLRYGPHADAMPSWLSLLNLLPGWMFAYQLGVCWGEKRIGRRGAWALLIGGAALFATLLLAFHYPESMVGVPGEVRTNSHPPSLLVLALAAAQSGAAMLLRDRIGRLLRRPALWAPVVVINLSAMTILCWHQTALLAAAIPGSFAGAIPGLTTSPDSLGWIAARVAWLPVFAGLLALIGRYTRGFEAPWKRSTHARRALAGLLAAGFAVFALGLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K047</accession>
    <name>A0A2M9K047_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DNA-binding response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CG723_05585</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000002">
        <property type="protein sequence ID" value="PJN12505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN12505">
        <property type="protein sequence ID" value="PJN12505"/>
        <property type="gene ID" value="CG723_05585"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="2"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="domain" description="HTH luxR-type" evidence="3">
        <location>
            <begin position="144"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PJN12505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="216" mass="23428" checksum="2F46655414908CF4" modified="2018-04-25" version="1">MRVVLAEDLFLLRDGLVRMLEAYDFEVAAAVESGPELTKALAELEPDVAVVDVRLPPSHTDEGLQCALAARRARPGLPVLVLSQHVEQLYARELLADGNGGIGYLLKDRVFDADQFIDAVRRVAAGGTAMDPQVIKQLLSRRAADAPLGGLTPREMEVLELMAQGRSNAAIAGQLVVTERAIAKHTSNIFLKLGLPVSDDDNRRVLAVIAYLDQVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K063</accession>
    <name>A0A2M9K063_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_05640</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000002">
        <property type="protein sequence ID" value="PJN12515.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN12515">
        <property type="protein sequence ID" value="PJN12515"/>
        <property type="gene ID" value="CG723_05640"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018721">
        <property type="entry name" value="DUF2252"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39441">
        <property type="entry name" value="PTHR39441"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10009">
        <property type="entry name" value="DUF2252"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN12515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="446" mass="48909" checksum="3A571947A33E80E9" modified="2018-04-25" version="1">MTTPQARAALGKEARKRASRSSHGAWIPSADRTDPVVVLERQAADRVAELLPIRYGRMAASPFAFLRGAAAVMTGDLATQRATGLTVQLCGDAHLLNFGLFASPERSLLFDVNDFDETSPGPFEWDVKRLAASVAVAARDNGHTDTQALRSARAAAAAYRTAMRRLSEMGELAVWYEHINAHQLLPLIRSGRSRRRVQATLAHATRRTSLHALGKLTEVVDGRRRIVRDPPLLEPASTPDTATVRKLFGDYRSTLAEERRRLLDRYRFVEAARKVVGVGSVGTRCFVVLLEGRDADDPLFLQIKEATRSVIEEYQPHGPYVHPGHRVVAGQRLLQASGDIFLGWMTGPQGRAFYWRQLRDMKGAADVAGLGPDDLRAYAELCGTALARAHARSGDRIAISGYLGRADIFDRAVADFALRYTDQNATDHTALRRAASEGLITIAPGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K0F3</accession>
    <name>A0A2M9K0F3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_05595</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000002">
        <property type="protein sequence ID" value="PJN12507.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN12507">
        <property type="protein sequence ID" value="PJN12507"/>
        <property type="gene ID" value="CG723_05595"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Epimerase" evidence="1">
        <location>
            <begin position="4"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN12507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="332" mass="34941" checksum="C57564DAA482F440" modified="2018-04-25" version="1">MKLLVLGGTEFVGRAVVEAAVARSWDVTVFHRGQHAAPEGVRSLHGDRTADGGLAALAESESEWDVVVDTWGAAPRAVRDSARLLAGRAGRYVYVSTSSVYTWAPPPGYTEDAPVVDGASPDAERTDYARDKRGGELAAVEAFGAGRALLVRCGLILGPYENIGRLPWWLGRIARGGPVLAPGPRELPLQYIDVRDLAAWVLDAAQAGLSGPYTVISPSGHTTMGGLLDACIRATGGDADLRWTAPEVIAAAGIEPWMQLPVWVPPGSDMHAALHSGDVAKAVAAGLRCRPVEETVADTWAWLESIGGKAPQRPDRPVLGLDPATEAKVLAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-05-25" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K0I7</accession>
    <name>A0A2M9K0I7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">NYN domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_06360</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000002">
        <property type="protein sequence ID" value="PJN12645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN12645">
        <property type="protein sequence ID" value="PJN12645"/>
        <property type="gene ID" value="CG723_06360"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004540">
        <property type="term" value="F:ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021139">
        <property type="entry name" value="NYN_MARF1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01936">
        <property type="entry name" value="NYN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NYN" evidence="2">
        <location>
            <begin position="32"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="224"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="249"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN12645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="441" mass="46833" checksum="B58B252164D92E55" modified="2018-04-25" version="1">MDRCIVLVDAGYLLGAAASLLAGEPSRSRIAVDHVALIQGLRERAESDTERQLLRIYWFDGAPDRVPQPEHRRLRVMPRVTVRLGALTRSDGRWAQKGVDAAMHAELTELARNRACSDIVLVTGDGDLLPGMMAAKEHGVAVHLWAVQAADGDYNQSEDLVAEADERRVLDRAWITKAVRAKEVGGICAPQPAPRPEIAAILSAPLPESALASAAGHSADLSDVAGGAGASVSGGGPGGAAGGDGADHGVAAREGDGGGAEDERGGVGRGVPTPKDLAALRGPGAAPGLGAHPHVHPAQHPANATLRWSSDKGWVERPGVVGESADAASLPTLAQLTTAEQRWADREEDITTVGGDPFEVGQVFARRWMERLGDQVELQKLSTMYPRVPHRIDGELLRYAARFGLLAHKDDQIDEHDRYAIRAGFWREVDVRSAAERVAAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K0Q4</accession>
    <name>A0A2M9K0Q4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CG723_06390</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000002">
        <property type="protein sequence ID" value="PJN12650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN12650">
        <property type="protein sequence ID" value="PJN12650"/>
        <property type="gene ID" value="CG723_06390"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PJN12650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="343" mass="37769" checksum="14E6A98465184BCD" modified="2018-04-25" version="1">MALLRALIRTARMVRHTSGLAAGLPPDDDVLLDVPDERLAPALVAAGRGEYEAAAKLLAATREAGEWENRDRYVTRLAAFARSRGEWFDDWRFAAPHDPDALLVKAELEVARGWESPARAELLREVTPLITAAAEGDPGDPVPWRVALDHARGTNASHTVFEKLWAEAVRRSPHHYGCHVSALQYLSAAWYGSHRECFDFAERAAQDALPGSLVQALPVRAAFAYLTSEEGPGPAAKVPRERLDEAADLASALSREYLADDPWPAEVRNLLTYVLVRLERWSDALEQLRLTGPYATSFPWDRISDDPLGQFLELRDGVRIEVAAARTLGGRDTGRGPLTSSSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K124</accession>
    <name>A0A2M9K124_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Metal-sulfur cluster biosynthetic enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_07355</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000002">
        <property type="protein sequence ID" value="PJN12821.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN12821">
        <property type="protein sequence ID" value="PJN12821"/>
        <property type="gene ID" value="CG723_07355"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034904">
        <property type="entry name" value="FSCA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002744">
        <property type="entry name" value="MIP18-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01883">
        <property type="entry name" value="FeS_assembly_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117916">
        <property type="entry name" value="SSF117916"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FeS_assembly_P" evidence="1">
        <location>
            <begin position="12"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN12821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="110" mass="12099" checksum="31A513D15F9AF850" modified="2018-04-25" version="1">MSETVTTKPASEEEVREALYDVVDPELGIDVVNLGLIYGIHIDDANIATIDMTLTSAACPLTDVIEDQAKSATDGIVNELRINWVWMPPWGPDKITDEGREQLRALGFNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-06-02" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K1N5</accession>
    <name>A0A2M9K1N5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_07760</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000002">
        <property type="protein sequence ID" value="PJN13028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN13028">
        <property type="protein sequence ID" value="PJN13028"/>
        <property type="gene ID" value="CG723_07760"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN13028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="442" mass="46995" checksum="D8516A29C126FFCD" modified="2018-04-25" version="1">MTQARPPRPAPRPPEGTPPPAELARMARRGLADAVRVARWADAVLSPGSGHGTPDGRGALSPPTAERAAADLDLTPRQVRADWDTARLAGLVEVHGDSARPGWRLRAWDRDDTAVLRGWVALFDAWSLAHPANKSLEAAAVAEVVEAMPQVLSLLQLSAGPVPVPQLLDLLGQRVEELRTERCEIPYGPQPEPTDTATATTGTTLPPLLDWALHGLAAVGALTYADSQATLTPLGSWAVWVKLEQICVAAQSPAGNIEQSADAMLRGCARLRPNAARAEYRAWLAARPVGSAVTELIAAARGEDALLRGLAFEALRVVGAPAEPVVRSVADEPPLRPYALLWLAEYEGADPEDVHMVLTREETTWLWVDTAAAVADHGEAQLLVRHLESAVQPTVPALLDEVRAAGHPRTVQVLVALAAAHPDPALAKAVRRAAFQVHTGGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K1N9</accession>
    <name>A0A2M9K1N9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">3-oxoacyl-ACP reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CG723_00070</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000001">
        <property type="protein sequence ID" value="PJN13043.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN13043">
        <property type="protein sequence ID" value="PJN13043"/>
        <property type="gene ID" value="CG723_00070"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PJN13043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="258" mass="26450" checksum="9A36409AC06FF897" modified="2018-04-25" version="1">MPVTAYDLTGRTAFVTGAASGIGRASALLLADAGATVHCADRDAQGLHATETLIKARGGTARTHALDVADRTQLAEAVAAAVDTTGRLDVMAAIAGIMHSSTVLETRDEDLDRVLGINFKGVLYACQEAARAMIATGTHGSIVTMASGAVDTGGPGLLCYGASKAAVVQLTKTLATEVGPQGIRVNAVAPGWIRTPMTGRHDASEQSHTEALMVRMSPLGRVGEADDIAHAVLHLASDASSFTTGQILRPNGGVAMPW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-09-29" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K279</accession>
    <name>A0A2M9K279_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Acetyl-CoA acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CG723_01175</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CB01635</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the thiolase-like superfamily. Thiolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000001">
        <property type="protein sequence ID" value="PJN13231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN13231">
        <property type="protein sequence ID" value="PJN13231"/>
        <property type="gene ID" value="CG723_01175"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00751">
        <property type="entry name" value="thiolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002155">
        <property type="entry name" value="Thiolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020617">
        <property type="entry name" value="Thiolase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020613">
        <property type="entry name" value="Thiolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020616">
        <property type="entry name" value="Thiolase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02803">
        <property type="entry name" value="Thiolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00108">
        <property type="entry name" value="Thiolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000429">
        <property type="entry name" value="Ac-CoA_Ac_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01930">
        <property type="entry name" value="AcCoA-C-Actrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00737">
        <property type="entry name" value="THIOLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Thiolase_N" evidence="4">
        <location>
            <begin position="8"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="domain" description="Thiolase_C" evidence="5">
        <location>
            <begin position="275"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-thioester intermediate" evidence="2">
        <location>
            <position position="96"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="2">
        <location>
            <position position="354"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="2">
        <location>
            <position position="385"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000429-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PJN13231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="408" mass="43558" checksum="34DE8BF1E3ABB3DB" modified="2018-04-25" version="1">MPRTVRDVVFVDGVRTPFGKAGPKGIYHETRADDLVVKAIRELLRRNPALDPAKIDEVAIAATTQIGDQGLTLGRTAGILAGLPQSVPGYSIDRMCAGALTAVTATAGSIAFGAYDAVIAGGVEHMGRHPMGEGVDPNPRFVSEKLVDESALFMGMTAENLHDRYPQITKQRADEYAVRSQEKAAKAYANGKIQQDLVPVSVRNTNPDVGETGWGLVTADEPMRPGTTLENLSGLKTPFRVHGRVTAGNAAGLNDGATASIIASEDFARENNLPVKMRLVSYAFVGVEPEVMGYGPIPATEKALAKAGLSIEDINLFEINEAFAIQVLAFLDHYGIADDDARVNQYGGAIAFGHPLASSGVRLMTQLARQFEEQPEVRYGLTTMCVGFGMGATVIWENPHHKDAGGDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K283</accession>
    <name>A0A2M9K283_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_00940</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000001">
        <property type="protein sequence ID" value="PJN13190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN13190">
        <property type="protein sequence ID" value="PJN13190"/>
        <property type="gene ID" value="CG723_00940"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046081">
        <property type="entry name" value="DUF6099"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19594">
        <property type="entry name" value="DUF6099"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="43"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN13190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="159" mass="16738" checksum="C1F59E58AF937851" modified="2018-04-25" version="1">MDAVRLIRASRRALAESQDAPAITREAWQAQALAQAMGNRLAREGPPELRGEARGLSEAGGRGCSGSALPVIGAGGIRAAQLTELPEAHKALIGLAALLGEVGIALVGIASEAEEEGDYWHCMDAIDAADESRDRVLEIIRRLGLRRDTMSESEPDSAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K2B9</accession>
    <name>A0A2M9K2B9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_01385</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000001">
        <property type="protein sequence ID" value="PJN13268.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN13268">
        <property type="protein sequence ID" value="PJN13268"/>
        <property type="gene ID" value="CG723_01385"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="50"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="76"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="117"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="149"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN13268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="180" mass="19277" checksum="9A90CCFBF8AC43D7" modified="2018-04-25" version="1">MKVLLRAVRAIDRVVVRALVNRDRSLARAPRRPGRVQAYGQRYPVRAGGLLGTATAALMVGICAVAGWRFTGAADALALVAIGAGAGLLLALTLRWERMAKEALEHIDRAEPFKASSVRSAVAWIAGTWVVLTVMWWSEDARQGSDADWLVSAVCAAVLTVLVSSAGFVVALVTGRRRSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K2E7</accession>
    <name>A0A2M9K2E7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_01540</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000001">
        <property type="protein sequence ID" value="PJN13291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN13291">
        <property type="protein sequence ID" value="PJN13291"/>
        <property type="gene ID" value="CG723_01540"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006059">
        <property type="entry name" value="SBP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01547">
        <property type="entry name" value="SBP_bac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014818980" evidence="1">
        <location>
            <begin position="28"/>
            <end position="428"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN13291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="428" mass="46319" checksum="B24F3CC78CDA0C15" modified="2018-04-25" version="1">MRRVRRLAAVAAAVALLLTGCSSGGTADDGKITLEFQSLAWQKESVDANKQLVKEWNAAHPDIQVKYVQGSWDSVHDQLLTSFEGGEAPDVIHDASDDLADFAYGGYLADLRDLLPARLKSDIPQHSWETATFGDGVYGVPFLQEPRVLIANAKILKAAGVRIPTPAKPWSWEEFRAVTKKLSGDEKFGVAWPLKEPVSATLNLSLSAGGRMFHRGADGKVTVRFDAADQVVPRTVHDQVDTDGSASGATLGMGGSDTLPGFFAGKYAMVPLGFSYRQQIVQQAPKGFDWQVLPAPAGRDGLAQGVSPQTLSVAEDSPHKKEAAQFIDFLLRPPNMVRLALGDWMLPTGTEALKDPALHTQKNDWATGTALAGDLRSAPAQSVRGYAEWKDKVATPALQEYYSGSIGLGELRKRLVKDGNLVLARYQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K2H0</accession>
    <name>A0A2M9K2H0_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Assimilatory sulfite reductase (ferredoxin)</fullName>
            <ecNumber evidence="3">1.8.7.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CG723_01675</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CB01635</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the reduction of sulfite to sulfide, a step in the biosynthesis of sulfur-containing amino acids and cofactors.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>3 H2O + hydrogen sulfide + 6 oxidized [2Fe-2S]-[ferredoxin] = 7 H(+) + 6 reduced [2Fe-2S]-[ferredoxin] + sulfite</text>
            <dbReference type="Rhea" id="RHEA:23132"/>
            <dbReference type="Rhea" id="RHEA-COMP:10000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10001"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17359"/>
            <dbReference type="ChEBI" id="CHEBI:29919"/>
            <dbReference type="ChEBI" id="CHEBI:33737"/>
            <dbReference type="ChEBI" id="CHEBI:33738"/>
            <dbReference type="EC" id="1.8.7.1"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.8.7.1" evidence="3"/>
    <dbReference type="EMBL" id="NNBL01000001">
        <property type="protein sequence ID" value="PJN13315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN13315">
        <property type="protein sequence ID" value="PJN13315"/>
        <property type="gene ID" value="CG723_01675"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050311">
        <property type="term" value="F:sulfite reductase (ferredoxin) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.413.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005117">
        <property type="entry name" value="NiRdtase/SiRdtase_haem-b_fer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036136">
        <property type="entry name" value="Nit/Sulf_reduc_fer-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006067">
        <property type="entry name" value="NO2/SO3_Rdtase_4Fe4S_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045854">
        <property type="entry name" value="NO2/SO3_Rdtase_4Fe4S_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006066">
        <property type="entry name" value="NO2/SO3_Rdtase_FeS/sirohaem_BS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01077">
        <property type="entry name" value="NIR_SIR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03460">
        <property type="entry name" value="NIR_SIR_ferr"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00397">
        <property type="entry name" value="SIROHAEM"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55124">
        <property type="entry name" value="SSF55124"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56014">
        <property type="entry name" value="SSF56014"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00365">
        <property type="entry name" value="NIR_SIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0349">Heme</keyword>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0883">Thioether bond</keyword>
    <feature type="domain" description="NIR_SIR_ferr" evidence="9">
        <location>
            <begin position="102"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="domain" description="NIR_SIR" evidence="8">
        <location>
            <begin position="173"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="domain" description="NIR_SIR_ferr" evidence="9">
        <location>
            <begin position="349"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="domain" description="NIR_SIR" evidence="8">
        <location>
            <begin position="426"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012353"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022784"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF03460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PJN13315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="565" mass="62743" checksum="51F5088E90852083" modified="2018-04-25" version="1">MAATPEKPTTAAPRRKVSRHRGEGQWAVGHFTPLNGNEQFKKDDDGLNVRTRIETIYSKRGFDSIDPNDLRGRMRWWGLYTQRKPGIDGGKTAILEPEELDDEYFMLRVRIDGGRLTTEQLRVIGEISQEFARGTADITDRQNIQYHWIRIEDVPEIWRRLEAVGLSTTEACGDTPRVILGSPVAGVAADEIIDGTPAIDEIQRRFIGNPEFSNLPRKFKTAISGSPQLDVAHEINDIAFVGVNHPEHGPGFDLWVGGGLSTNPKLGQRLGAWVPLDEVPDVYGGVIGIFRDYGYRRLRTRARLKFLLADWGTEKFRQVLEDEYLQRKLVDGPAPEQPAGTWRDHLGVHRQKDGLFYVGFAPRVGRVDGTTLTKIAEVAGAHGSGRLRTTAEQKMIVLDVAEDQVESLVASLEALDLKVNASPFRRGTMACTGIEFCKLAIVETKARGASLIDELERRVPEFDEPLTININGCPNACARIQVADIGLKGQLMLDADGNQVEGYQVHLGGALGLEAGFGRKVRGLKVTAAELPDYVERVLKRFQAEREDGERFATWTSRASEEALS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K2N5</accession>
    <name>A0A2M9K2N5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CG723_02070</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CB01635</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CorA metal ion transporter (MIT) (TC 1.A.35) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000001">
        <property type="protein sequence ID" value="PJN13386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN13386">
        <property type="protein sequence ID" value="PJN13386"/>
        <property type="gene ID" value="CG723_02070"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046873">
        <property type="term" value="F:metal ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045861">
        <property type="entry name" value="CorA_cytoplasmic_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045863">
        <property type="entry name" value="CorA_TM1_TM2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002523">
        <property type="entry name" value="MgTranspt_CorA/ZnTranspt_ZntB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01544">
        <property type="entry name" value="CorA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143865">
        <property type="entry name" value="SSF143865"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144083">
        <property type="entry name" value="SSF144083"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="330"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="361"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="29"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PJN13386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="387" mass="43015" checksum="2EE6D68B6CDB6AB4" modified="2018-04-25" version="1">MAERRTRPGAEPKKYMWRRAAGQSPANPPETDTTPPPPATPTDPASETASVVQAALYRDGVRVSSPVTLAETFRELREQQDGMAWIGLARPTESELLSLAGEFDLHPLAVEDALEAHQRPKLERYGDTLFVVLRAARYLDAPEEVEFGELHVFVGADFVITVRHGAAPDLSGVRRRMEDSPELLKLGPEAVLYAILDAVVDGYAPVVAGVQTDIDEIETEVFSGAPEVSRRIYELSREMVEFQRATRPLVGMLHALMAGFAKYGTDEELQRYLRDVADHVTHTSERVDGFRQALADILTVNATQVTQQQNAEMRALAEAGFEQNEEIKKISSWAAILFAPTLVGTIYGMNFDQMPELHWVGGYPFAIVLMAVVCTSLYVIFKKRDWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-09-29" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K2Z6</accession>
    <name>A0A2M9K2Z6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Radical SAM protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CG723_02775</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000001">
        <property type="protein sequence ID" value="PJN13506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN13506">
        <property type="protein sequence ID" value="PJN13506"/>
        <property type="gene ID" value="CG723_02775"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040086">
        <property type="entry name" value="MJ0683-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43432">
        <property type="entry name" value="PTHR43432"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01084">
        <property type="entry name" value="Uncharacterised_Radical_SAM_Su"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="domain" description="Radical SAM core" evidence="7">
        <location>
            <begin position="60"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="324"/>
            <end position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PJN13506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="348" mass="39024" checksum="39693FFC72D5D51B" modified="2018-04-25" version="1">MRWENLTENPAEIPTGRVTDAALFGADSVITRTFDTPEFAGVTFHEIRARSIVNRVPGASRMPFEWTVNPYRGCTHACVYCFARKTHSYLDLDTGLGFDSQIVVKVNAPDLLRRHLASRRWHGEHIAMGTNVDCYQRAEGRYRLMPGIIEALRDYANPFSILTKGTLILRDLDLLRQAAEVTDVGVSVSVGFVDRELWRTVEPGTPAPERRLDVVRALGEAGIGCGVLMAPVIPFLGDHPGQLRETVRAVAAAGATSVTPLVLHLRPGAREWFMSWLGHHHPHLVRRYERLYAEGAYAPKWYQRRITRQVHELAEEFGIGPSRAEAPRRLRARQEPEPAPAATQLTLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K3B3</accession>
    <name>A0A2M9K3B3_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">PAP2_3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CG723_03415</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CB01635</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000001">
        <property type="protein sequence ID" value="PJN13615.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN13615">
        <property type="protein sequence ID" value="PJN13615"/>
        <property type="gene ID" value="CG723_03415"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026841">
        <property type="entry name" value="Aur1/Ipt1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14378">
        <property type="entry name" value="PAP2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="101"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="131"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="184"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="212"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="236"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="domain" description="PAP2_3" evidence="7">
        <location>
            <begin position="68"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF14378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PJN13615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="351" mass="37280" checksum="98C7AA4CCE9DE3BB" modified="2018-04-25" version="1">MNSLTEPAEPEPDTAGRETDAVGHQPDVVARPPLVRELLLVVGLFLVYKFGRQLANGHTGEAFHNAHRVWDLERAVHLPGEGAVQHALLHSDGLVHIANTYYATVHFPATAAFLIWLYLCRPRHYIWTRRVLAALTAAALVLHLTFPLAPPRMLAAAHLVDTGQVYGPTVYGATPQTDSMANQFAAMPSLHFGWALMVAVGLIAATRSRLRWLWLLHPALTLFVVVGTANHYWLDAIVATALLGIALAVIRLPGTTQAAKPGRSIGRRLLPAPRAAASLTATAETMGAAIPAPWTPAHQRGGSLSASEVLARIPVSVTAGSVSAVDAPVASVTSGAARPGREVLTASGAHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-09-29" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JFE0</accession>
    <name>A0A2M9JFE0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_43695</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000044">
        <property type="protein sequence ID" value="PJN05608.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN05608">
        <property type="protein sequence ID" value="PJN05608"/>
        <property type="gene ID" value="CG723_43695"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041413">
        <property type="entry name" value="MLTR_LBD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17765">
        <property type="entry name" value="MLTR_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="2">
        <location>
            <begin position="42"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="282"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN05608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="305" mass="33713" checksum="52FE7F8300E3B64C" modified="2018-04-25" version="1">MASESAHSEGAELGRYLRARRTQTSPEHVGLTVGAGIRRTPGLRREELATLAGISIDYYVRMERGKETRPSPAVLDSLARALHMDDQEHQHLRELAARAARYVPDPPPAPSRTVRPHLKLLLESLRPNPAYVISRSMDMLAWNPGGLALYAGLDDWPVKQRNLARYLFLHPVARDLFADWDRQITACVARLRAIAGTAPDAPDLTHLVGELLLKSPDFAGLWERYEVTGRKPAHKTFQHPQVGTVTLTSQSLHVEGTPGQRIGVYTAEPGTPDHDALLLLDMTAPQSAPRPEPAPEATGQQTRRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JFK1</accession>
    <name>A0A2M9JFK1_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Stress-response A/B barrel domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_43485</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000043">
        <property type="protein sequence ID" value="PJN05675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN05675">
        <property type="protein sequence ID" value="PJN05675"/>
        <property type="gene ID" value="CG723_43485"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013097">
        <property type="entry name" value="Dabb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07876">
        <property type="entry name" value="Dabb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00886">
        <property type="entry name" value="Dabb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51502">
        <property type="entry name" value="S_R_A_B_BARREL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Stress-response A/B barrel" evidence="1">
        <location>
            <begin position="2"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN05675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="97" mass="11365" checksum="7A2DE10F1CF04EEB" modified="2018-04-25" version="1">MIRHLVLFKLNEGVQRDEPRVVEGVKAFRALGEQIPELTFWECDWNITDRPIAYDFAINSAVEDTDALKRYIEHPAHQAGVAQWREFATWVIADYEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JFK8</accession>
    <name>A0A2M9JFK8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Metal-dependent hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_43545</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000043">
        <property type="protein sequence ID" value="PJN05685.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN05685">
        <property type="protein sequence ID" value="PJN05685"/>
        <property type="gene ID" value="CG723_43545"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03372">
        <property type="entry name" value="Exo_endo_phos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="SSF56219"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014961453" evidence="1">
        <location>
            <begin position="29"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="domain" description="Endo/exonuclease/phosphatase" evidence="2">
        <location>
            <begin position="40"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN05685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="286" mass="30707" checksum="C7DCAC1DD3CDB5E7" modified="2018-04-25" version="1">MSKHRRTPHVLLAAGLLGGLAAAPPAQAAGGPPPVPLRIATYNIHAGSGMDNVFDLDRQEAALRALHADVIGLQEVDVHWDARSQNRDLAEELADRLGMHVSFAPIYSLDPVEEGGPRREYGVAVLSRYPVRGAANHEITRLSTQDPNPVPAPAPGFGEVELKVRGVPVQVFVTHLDYRSDPSVRAAQVADTRRIMAAERTSPTDRQILLGDFNAAPDAPELAPLWKELTPADPGANTFPAADPVKRIDYVAVGEGVRVRDAAVAETLASDHRPVVADLALTRKSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JFV8</accession>
    <name>A0A2M9JFV8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CG723_42760</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CB01635</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000041">
        <property type="protein sequence ID" value="PJN05761.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN05761">
        <property type="protein sequence ID" value="PJN05761"/>
        <property type="gene ID" value="CG723_42760"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="23"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="58"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="91"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="116"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="149"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="177"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="211"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="242"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="280"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="317"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="346"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="372"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="481"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="7">
        <location>
            <begin position="25"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="518"/>
            <end position="543"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PJN05761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="543" mass="56278" checksum="0FC621D581D27CE8" modified="2018-04-25" version="1">MTGTITATAPSRLRTAGPGANRWVVLVVLCTSLLLVALDATVLHVAVPAVTQDLRPSAVQLLWIVDAYPLICAALLILFGTLGDRVGRRRVLLLGYGLFGVASALAVFASTPHILILARALLGVGGAMIMPATLSILRAVFPDRRERAVAIGVWSAVAAIGAATGPVLGGFMVEHFWWGSVFLINIPLMAIMLPLGRLILPESKGRSDGPWDVVGAFMAAVGMLGVVYGVKRLGVDRDLLDPSAVGPLLVGAAVLIVFVRRQKRREHPLIDMKMFARPAFSTAVGCIVLAMLALVGLELIAVQYLQLVLGLSPLETGVRLLPLTFAAMAAGVLGSAQLRRFGPRRMVSAGFVLTAAAVLMLTPMGQHDRPSLLTFGFVLLGFGLQTTLFGAYESMLSEASAEDAGGAAAIGETSYQLGAGMGIALLGSVMNAAYAPGIARVTGVPGSASAHAGNSLGEAYQVATRLGGTAGEALRSAARVAFVHGLHVTLFVSAGLLLLGAVAALRLPKRMECEAAAPQDAEGTAKIGPQRGPERVGVESTVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JG96</accession>
    <name>A0A2M9JG96_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HTH tetR-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_41980</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000038">
        <property type="protein sequence ID" value="PJN05906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN05906">
        <property type="protein sequence ID" value="PJN05906"/>
        <property type="gene ID" value="CG723_41980"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="23"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="51"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00440"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN05906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="73" mass="7929" checksum="68F68FA779E1C254" modified="2018-04-25" version="1">MSPLGPRTAVVFTVTARASRPSGYDQTTVDEITEAADVARGAFFNHFQRKEAHRRMGRTAARTAAPGAEGRRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JGF2</accession>
    <name>A0A2M9JGF2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cobyrinic acid a,c-diamide synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_42025</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000038">
        <property type="protein sequence ID" value="PJN05913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN05913">
        <property type="protein sequence ID" value="PJN05913"/>
        <property type="gene ID" value="CG723_42025"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025669">
        <property type="entry name" value="AAA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13614">
        <property type="entry name" value="AAA_31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA_31" evidence="1">
        <location>
            <begin position="1"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN05913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="294" mass="32012" checksum="1E1EBE003DF23536" modified="2018-04-25" version="1">MKVIAVATQKGGVGKTSTTVNLAAGLALAGARVLIVDLDPQAQAGTAVGVNLVGEDQLARSLGWVLQARLQGMRMDLAGVWFDRCELLEEWEDAGTLHLLACEESTMTSAQDLIHKKGFQSTPILRRMLVEIEDQFDFVVIDTPPAVSSLSATALAAADFVITVCIPEYPALKGAAATRGTVKYVKDRTGGECEPQYLGAVLNRSNPPSRWKAQEVNIRNGMLDADLFPFQTDIRLDNRISDSFAYGVPSVIRFASHTPGKMYSELMGQIVERMQLPAEKWQTPERIESEDSGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JGJ4</accession>
    <name>A0A2M9JGJ4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Deaminase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_41890</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000037">
        <property type="protein sequence ID" value="PJN06000.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN06000">
        <property type="protein sequence ID" value="PJN06000"/>
        <property type="gene ID" value="CG723_41890"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008703">
        <property type="term" value="F:5-amino-6-(5-phosphoribosylamino)uracil reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009231">
        <property type="term" value="P:riboflavin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.430.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024072">
        <property type="entry name" value="DHFR-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002734">
        <property type="entry name" value="RibDG_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01872">
        <property type="entry name" value="RibD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53597">
        <property type="entry name" value="SSF53597"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RibD_C" evidence="1">
        <location>
            <begin position="4"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN06000.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="195" mass="21560" checksum="E7904BEE7D057ADC" modified="2018-04-25" version="1">MRDIILGMSVSLDGYIEGPDRDISWHRVDEELHRYFNAELAGMSAFIDGRVTHELMVSVWPTVDADPDCGETMAEFAGIWRNMPKIVFSRTLENTAENTDWNTTIVRDVVVEDILALKAQPGGDMSLGGAGLAARFMELDLVDEFRVYVHPVLIGGGKPLFPAAGRAVALRLMETRTFGNGVVMLRYRRAAEAAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JGW0</accession>
    <name>A0A2M9JGW0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CG723_40880</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000035">
        <property type="protein sequence ID" value="PJN06105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN06105">
        <property type="protein sequence ID" value="PJN06105"/>
        <property type="gene ID" value="CG723_40880"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PJN06105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="167" mass="18593" checksum="6A5B421845998FD8" modified="2018-04-25" version="1">MLIARSPEGAPPIEGGWRRSEKMGLLATQHLDAEVMFYGLWMEDIGASFDDEPKPDAPFGSSTGGRVVIHSGGHTHTADFCAEVWDEEPPEAPGPWEKVAQTQIDAPAGQVRLWTYAAMTKEDIVLGQPGRTWRVRVHVRGREEVHKLAQLDVPEGIEHYLVQFWPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JH24</accession>
    <name>A0A2M9JH24_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">LysR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_40620</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LysR transcriptional regulatory family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000034">
        <property type="protein sequence ID" value="PJN06180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN06180">
        <property type="protein sequence ID" value="PJN06180"/>
        <property type="gene ID" value="CG723_40620"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005119">
        <property type="entry name" value="LysR_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000847">
        <property type="entry name" value="Tscrpt_reg_HTH_LysR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00126">
        <property type="entry name" value="HTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03466">
        <property type="entry name" value="LysR_substrate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50931">
        <property type="entry name" value="HTH_LYSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH lysR-type" evidence="2">
        <location>
            <begin position="2"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN06180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="321" mass="35004" checksum="4D1EA02B77BD74A8" modified="2018-04-25" version="1">MLNVRRLLLLAEVAERGSLTAAAEALSMTTSAASQQMSLLEREAGQPLIERLPRGARTTAAGAALAERGRVIRRELQAAEADLEAFGHLDRGVVTLGSFPTASASLLPLALTRFRRAHPQVRTVVRAGVLAQLREMLHTGEVELSLMWDYDWNRVDDDQLILTPLLEDPTVLVVPTSSPLVSSDQVRLSDLADQEWIIRAENHPVADVLRRACRQAGFEPRIAYASHDYQEAQAMVAAGLGLALAPRLALTNRRSDVRLLPLSHEQSASELSPVRRILLARPAQRASTPAAQAMARVLHAVARGFTDPGLDRSQLGAVRTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JH35</accession>
    <name>A0A2M9JH35_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Peptide ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CG723_40580</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CB01635</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000034">
        <property type="protein sequence ID" value="PJN06175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN06175">
        <property type="protein sequence ID" value="PJN06175"/>
        <property type="gene ID" value="CG723_40580"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015833">
        <property type="term" value="P:peptide transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013563">
        <property type="entry name" value="Oligopep_ABC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08352">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01727">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="21"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="89"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="204"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="247"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="10">
        <location>
            <begin position="83"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="9">
        <location>
            <begin position="310"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="346"/>
            <end position="353"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PJN06175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="643" mass="67740" checksum="39F59C251923763E" modified="2018-04-25" version="1">MTSTSQWRRRGSAWSAAARTPMGACSLALLVALAALAILGPVLWGEQAAAVDTNAIGQGPSGAHLLGTDSLGRDIFYRTLVATRFSVELAVIATAVGVTVGLLLGTLPSVLPRRAGRLITSAVDIAVAFPGLLLALFFAVIFGVGTRGAVLAIAFATAPGFARLAQTLAASVAGRDYVSAARIAGVGRLRLLVRHVLPNIGEPLMVNATISAGGALLAFASLSFLGIGVQAPRYDWGRLLGEGLDGIYVTPAAALAPGAAVVLAGLAFNLVGETVAAVVGVRTPTARIPARPAPPARPAAAEEPTAKPVLLVENLHVAFPRADGWTVPVRGVSFTVRDGEAIGVVGESGSGKSLTGLAVSRLIETPGVVTADRLEFAGTPLLTTPERELRELLGTSLAMVFQDPTSSFNPTRRIGRQLAEASEQHHGLNRREAFARAVDRLREVRIPAAERRARQYPHQFSGGMRQRAMIGMGLMGEPKLIIADEPTTALDVTVQRQVLRLLARTRETENAAILLISHDIAVVAQTCDRMLVMYAGRVVEDLPTADLMSVPRHPYTRALLAATLELDTDRDEPLAVVPGRPPEPDQVPEGCAFAARCPVATDRCRSEDPVLERADRAHRVACWHPKGAVARESGREAAYGGAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-05-25" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JHA9</accession>
    <name>A0A2M9JHA9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Sugar isomerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_40145</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000033">
        <property type="protein sequence ID" value="PJN06233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN06233">
        <property type="protein sequence ID" value="PJN06233"/>
        <property type="gene ID" value="CG723_40145"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097367">
        <property type="term" value="F:carbohydrate derivative binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901135">
        <property type="term" value="P:carbohydrate derivative metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05008">
        <property type="entry name" value="SIS_GlmS_GlmD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05009">
        <property type="entry name" value="SIS_GlmS_GlmD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035466">
        <property type="entry name" value="GlmS/AgaS_SIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035490">
        <property type="entry name" value="GlmS/FrlB_SIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001347">
        <property type="entry name" value="SIS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046348">
        <property type="entry name" value="SIS_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01380">
        <property type="entry name" value="SIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53697">
        <property type="entry name" value="SSF53697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51464">
        <property type="entry name" value="SIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="SIS" evidence="2">
        <location>
            <begin position="26"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN06233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="294" mass="30974" checksum="6598D918CFE5721A" modified="2018-04-25" version="1">MSHVENELNSQPECWTRAAGLAAGEAAKLPAPGERVAIVGCGTSWFMAQAFAALREQSGQGETDAFAASEFPAGRPYDRLIALSRSGTTTEVVELLAAVKGRIRTTAVIGDPNTPIVSAADDVIVLDFADEQSVVQTRFATTALTLLRAHLGLHTEQAVADARTALETPLPEGLVECGQFTFLGRGWTVGLANEAALKMREASLSWTEAYPAMEYRHGPISVTTAGTATWMIGTAPEGLAEQVTGTGALWVEGSLDPLAELVRAQRLAVAVAAARGLDPDQPRHLTRSVILTAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JHJ8</accession>
    <name>A0A2M9JHJ8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">12-oxophytodienoate reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_39520</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000031">
        <property type="protein sequence ID" value="PJN06355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN06355">
        <property type="protein sequence ID" value="PJN06355"/>
        <property type="gene ID" value="CG723_39520"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001155">
        <property type="entry name" value="OxRdtase_FMN_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045247">
        <property type="entry name" value="Oye-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22893">
        <property type="entry name" value="PTHR22893"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00724">
        <property type="entry name" value="Oxidored_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Oxidored_FMN" evidence="1">
        <location>
            <begin position="17"/>
            <end position="361"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN06355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="376" mass="40372" checksum="39A497CF56149AFB" modified="2018-04-25" version="1">MTDAASPDSRAAEILSRPIALNGLKVPNRIAMAPMTRMFSPNGIPGEDVRSYYSRRAAAGVGLIVTEGTYVGHDSAGESDRVPRFHGEEQLAGWAKVAEDVHAAGGTIVPQLWHIGMVRQQGKPPFAEAPAVGPSGLRIDGTEGTGKAMTQGDLDDVIGAFAQAAKDAERIGFDGVEVHGAHGYLLDQFLWAGTNRRTDGYGGDAVARTKFAAEIVAAIRENVSPGFPVIFRYSQWKQEAYEARLAETPEELEAILNPLTAAGVDAFHASTRRYWNPEFDGSDLNLAGWTKKVTGKPTITVGSVGLDGDFIRAFMGEGSAVKGIDDLLDRLERDEFDMVAIGRALLQDPEWAAKVLAGRFDELTPYDAEAALKTLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JHT3</accession>
    <name>A0A2M9JHT3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Amino acid ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CG723_39195</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CB01635</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000030">
        <property type="protein sequence ID" value="PJN06434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN06434">
        <property type="protein sequence ID" value="PJN06434"/>
        <property type="gene ID" value="CG723_39195"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="26"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="91"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="123"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="166"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="226"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="273"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="88"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PJN06434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="302" mass="32462" checksum="B740BCDAED0173C5" modified="2018-04-25" version="1">MTLTASAPATRAPAKTPSPGRRSLRWLLPLAPALVLIAIFLVGPILWSVWIAFTNETLTGSASVNSHFVGLDNFTRLFGDDAFTGSLVRTLVFVLFSAVLGQNVLGLLIALVLRGKNRVVRGVVNGVVIAAWVVPEVVAAACWFSFLDEKGTLNSVLGVHQEWLVSAPMLAVILANTWRGTAFSMLVYSAALSEVPRDVMEAAKVDGASTGRTFFSVTLPLIQRSVLSNLMLTTLQTLASFGLIYALTGGGPGEESQTTPLYMYEQAFKYFEVGYGSAIALVMLLFGGLLSLVYLRLIKVED</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JI39</accession>
    <name>A0A2M9JI39_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Polysaccharide deacetylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_38905</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000029">
        <property type="protein sequence ID" value="PJN06512.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN06512">
        <property type="protein sequence ID" value="PJN06512"/>
        <property type="gene ID" value="CG723_38905"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002509">
        <property type="entry name" value="NODB_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01522">
        <property type="entry name" value="Polysacc_deac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="SSF88713"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51677">
        <property type="entry name" value="NODB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NodB homology" evidence="2">
        <location>
            <begin position="102"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="61"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN06512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="288" mass="30871" checksum="F164AD0426A27DED" modified="2018-04-25" version="1">MKIYLRRYPVFIKTLGSISLACHLLTLNGAVTSTDRRAALRFGAGLTAAALTTGCSTTARDPVAAGHSASPSHPARAAPPAPAPRRFPGQPAQIDHGPRDRPRVALTFHGQGDPAIAYALLKEAERGHAKVTVLAVGTWLDEHPAVARRILDGGHDLGNHTLNHRDINTMSEAEARAEITGCADRIRRLTGSIGTWFRPSRTQRATPLVESLARTAGYPHVLSYDVDSLDYTSPGAAEVTRKVTSEIREGSVVSLHFGYKDTVVALPALLEDLDRRGLAAVTTTELLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JJD1</accession>
    <name>A0A2M9JJD1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CG723_36460</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000024">
        <property type="protein sequence ID" value="PJN06978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN06978">
        <property type="protein sequence ID" value="PJN06978"/>
        <property type="gene ID" value="CG723_36460"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PJN06978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="446" mass="47357" checksum="6B13556FF965BC72" modified="2018-04-25" version="1">MTTVLSTEWDSVRQRARLSSQAAGTGVPLERPTALERAELLGRLRWEVIQGGSLFLVYPQLLDGAVFAGLRPAELLDELTIRAIDGGAALPLRVNARGADLAGQLIAMLSTGFVFSSLPVPDDQCLRLQQELSARADHRAAAELLMAEGPAGAADRLLAATGVLDAPLRRRTVARWRDWLEAAERGLLQVSSLVPADYPAAYALCPPPRPEALASDSGRAALASWIGGEYDRNGLPNRSLLYESLDPLLYSGDGAERADAQLLRESFDETYYRAIAVSEGCALGLASPRRGLRRREAAVLPASTRVVLFPTRFELRLGLMTAAAWQRYTDDVADALTSWWQHRDLTALQDVGDLLAARTKEPASGGEDEVSVTRLQQLVRQASGVTAQVVAGGGMSAATGVLGGGTPGAFAAGAGGALAPMLVAAVTAGVNHLSSFRGRYDVIELP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JJN4</accession>
    <name>A0A2M9JJN4_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 11">L-aspartate oxidase</fullName>
            <ecNumber evidence="4 11">1.4.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CG723_35790</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">CB01635</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Catalyzes the oxidation of L-aspartate to iminoaspartate, the first step in the de novo biosynthesis of NAD(+).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-aspartate + O2 = H2O2 + iminosuccinate</text>
            <dbReference type="Rhea" id="RHEA:25876"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:77875"/>
            <dbReference type="EC" id="1.4.3.16"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:25877"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 11">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2 11">Cofactor biosynthesis; NAD(+) biosynthesis; iminoaspartate from L-aspartate (oxidase route): step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the FAD-dependent oxidoreductase 2 family. NadB subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.4.3.16" evidence="4 11"/>
    <dbReference type="EMBL" id="NNBL01000023">
        <property type="protein sequence ID" value="PJN07095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN07095">
        <property type="protein sequence ID" value="PJN07095"/>
        <property type="gene ID" value="CG723_35790"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00253">
        <property type="reaction ID" value="UER00326"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008734">
        <property type="term" value="F:L-aspartate oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044318">
        <property type="term" value="F:L-aspartate:fumarate oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033765">
        <property type="term" value="F:steroid dehydrogenase activity, acting on the CH-CH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009435">
        <property type="term" value="P:NAD biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008202">
        <property type="term" value="P:steroid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.700.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003953">
        <property type="entry name" value="FAD-binding_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037099">
        <property type="entry name" value="Fum_R/Succ_DH_flav-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015939">
        <property type="entry name" value="Fum_Rdtase/Succ_DH_flav-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005288">
        <property type="entry name" value="NadB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027477">
        <property type="entry name" value="Succ_DH/fumarate_Rdtase_cat_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42716">
        <property type="entry name" value="PTHR42716"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00890">
        <property type="entry name" value="FAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02910">
        <property type="entry name" value="Succ_DH_flav_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46977">
        <property type="entry name" value="SSF46977"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56425">
        <property type="entry name" value="SSF56425"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00551">
        <property type="entry name" value="nadB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0274">FAD</keyword>
    <keyword evidence="5 11" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8 11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6 11" id="KW-0662">Pyridine nucleotide biosynthesis</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD_binding_2" evidence="13">
        <location>
            <begin position="29"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="domain" description="Succ_DH_flav_C" evidence="14">
        <location>
            <begin position="457"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="560"/>
            <end position="584"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00029281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00029426"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU362049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF02910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="PJN07095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="584" mass="61191" checksum="84E6C523853B3020" modified="2018-04-25" version="1">MSATGTTVTGTATGIRLHAPAPGWSVTADVVIVGSGVAGLTAALRCQAAGLRTVVVTKARLDDGSTRWAQGGVAAALGDGDTPEQHLEDTLVAGVGLCDEEAVRTLVTEGPDAVRRLIATGAHFDESADGDLALTREGGHHRRRIAHAGGDATGAEISRALVEAVRARGIRTVENALVLDLLTDADGRTAGVSLHVMGEGQHDGVGAALAPAVVLATGGMGQVFSATTNPHVSTGDGVALALRAGAEVSDLEFVQFHPTVLFLGADAEGQQPLVSEAVRGEGAHLVDADGVRFMVGQHELAELAPRDIVAKGITRRMQEQGAEHMYLDARHFGAEMWENRFPTILAACRAHGIDPVTEPVPVAPAAHYASGGVRTDLQGRTTVPGLYACGEVACTGVHGANRLASNSLLEGLVYAERIADDIAASHRENGLHARVPAPVPHPEIPTHPLMPPEARFAIQRVMTQGAGVLRSADSLAEAAAGLGRIHAEAAGALAENGKTAEPGVDTWEATNLLCVARVLVAAARRREETRGCHWREDHADRDDAAWRRHIVVRLNPDRTLAAHTTPTAEFPPTRPECRTHQQEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-05-25" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JJP0</accession>
    <name>A0A2M9JJP0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_35765</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000023">
        <property type="protein sequence ID" value="PJN07090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN07090">
        <property type="protein sequence ID" value="PJN07090"/>
        <property type="gene ID" value="CG723_35765"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045981">
        <property type="entry name" value="DUF5937"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001845">
        <property type="entry name" value="HTH_ArsR_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19361">
        <property type="entry name" value="DUF5937"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00778">
        <property type="entry name" value="HTHARSR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00418">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50987">
        <property type="entry name" value="HTH_ARSR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH arsR-type" evidence="1">
        <location>
            <begin position="276"/>
            <end position="368"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN07090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="368" mass="40449" checksum="8258A504FA62A085" modified="2018-04-25" version="1">MSVSIDISGLAPERISVVPSPLSELGMALHALAEPAHHPGLQGWTTAVSARLDPGLADRLCEADFLWRTTFSDVFAPFAGIPGRAALPGATLAEELDLLDKLTDRQFVDAALEFTCQNSYALREANPLEDPDMHRRALDLAATRGLPQVQFTQRLLDDPPAVRAWFRRLVEDCEEAFFADIWARVHHQLAADARHKTELLRRKGLAEALTAVSSVVTLDEPANLITVDKITVGRTTTEDGGLVLVPTSLGWPHLMVLHRFGWQPAITYPVGSPGLTTPATVEQLTRRMTALAHPVRMRLCRHLARGAYTTSELSDAHGMTAPEISRHLTVLKKAGLITTRRRGRYVQHQLDLTAVARLGSDFIEGVLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-06-02" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JJW4</accession>
    <name>A0A2M9JJW4_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5">Urease subunit gamma</fullName>
            <ecNumber evidence="4 5">3.5.1.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Urea amidohydrolase subunit gamma</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">ureA</name>
        <name evidence="6" type="ORF">CG723_34780</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CB01635</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 4">
            <text>2 H(+) + H2O + urea = CO2 + 2 NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:20557"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16199"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="EC" id="3.5.1.5"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Nitrogen metabolism; urea degradation; CO(2) and NH(3) from urea (urease route): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Heterotrimer of UreA (gamma), UreB (beta) and UreC (alpha) subunits. Three heterotrimers associate to form the active enzyme.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4 5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 5">Belongs to the urease gamma subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.5" evidence="4 5"/>
    <dbReference type="EMBL" id="NNBL01000022">
        <property type="protein sequence ID" value="PJN07163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN07163">
        <property type="protein sequence ID" value="PJN07163"/>
        <property type="gene ID" value="CG723_34780"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00258">
        <property type="reaction ID" value="UER00370"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016151">
        <property type="term" value="F:nickel cation binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009039">
        <property type="term" value="F:urease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043419">
        <property type="term" value="P:urea catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00390">
        <property type="entry name" value="Urease_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.280.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00739">
        <property type="entry name" value="Urease_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012010">
        <property type="entry name" value="Urease_gamma"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002026">
        <property type="entry name" value="Urease_gamma/gamma-beta_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036463">
        <property type="entry name" value="Urease_gamma_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00547">
        <property type="entry name" value="Urease_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001223">
        <property type="entry name" value="Urease_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54111">
        <property type="entry name" value="SSF54111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00193">
        <property type="entry name" value="urease_gam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 4 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PJN07163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="100" mass="11109" checksum="883E98DB5C3EE624" modified="2018-04-25" version="1">MQLTPHEQERLLIHVAADVAEKRRSRGLKLNHPEAIALLTSHILEGARDGRTVAELMSSGRKVLTRDDVMEGIPEMIHDVQVEATFPDGTKLVTVHDPIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JJY7</accession>
    <name>A0A2M9JJY7_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Type III pantothenate kinase</fullName>
            <ecNumber evidence="6">2.7.1.33</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">PanK-III</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Pantothenic acid kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">coaX</name>
        <name evidence="7" type="ORF">CG723_35800</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CB01635</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>(R)-pantothenate + ATP = (R)-4'-phosphopantothenate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16373"/>
            <dbReference type="ChEBI" id="CHEBI:10986"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29032"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.33"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>NH4(+)</name>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
        </cofactor>
        <cofactor evidence="6">
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </cofactor>
        <text evidence="6">A monovalent cation. Ammonium or potassium.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 6">Cofactor biosynthesis; coenzyme A biosynthesis; CoA from (R)-pantothenate: step 1/5.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the type III pantothenate kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.33" evidence="6"/>
    <dbReference type="EMBL" id="NNBL01000023">
        <property type="protein sequence ID" value="PJN07097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN07097">
        <property type="protein sequence ID" value="PJN07097"/>
        <property type="gene ID" value="CG723_35800"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00241">
        <property type="reaction ID" value="UER00352"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004594">
        <property type="term" value="F:pantothenate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015937">
        <property type="term" value="P:coenzyme A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01274">
        <property type="entry name" value="Pantothen_kinase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004619">
        <property type="entry name" value="Type_III_PanK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34265">
        <property type="entry name" value="PTHR34265"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03309">
        <property type="entry name" value="Pan_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00671">
        <property type="entry name" value="baf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 6" id="KW-0173">Coenzyme A biosynthesis</keyword>
    <keyword evidence="4 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 7" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0630">Potassium</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="6">
        <location>
            <begin position="112"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="6">
        <location>
            <position position="114"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="6"/>
            <end position="13"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="134"/>
        </location>
        <ligand>
            <name>a monovalent cation</name>
            <dbReference type="ChEBI" id="CHEBI:60242"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="137"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="189"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PJN07097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="265" mass="28145" checksum="DFACC047F85D2E1B" modified="2018-04-25" version="1">MLLTIDVGNTHTVLGLFDGEEIVEHWRISTDARRTADELAVLLQGLMGMHPLLGDELGDGIDGIAICSTVPSVLHELREVTRRYYGDVPAVLVEPGIKTGVPILMDNPKEVGADRIINAVAAVELYGGPAIVVDFGTATTFDAVSARGEYAGGVIAPGIEISVEALGVRGAQLRKIEIARPRSVIGKNTVEAMQSGILYGFAGQVDGVVTRMARELADDPDDVTVIATGGLAPMVLGEAAVIDEHEPWLTLIGLRLVYERNVSRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JK11</accession>
    <name>A0A2M9JK11_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_35055</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000022">
        <property type="protein sequence ID" value="PJN07210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN07210">
        <property type="protein sequence ID" value="PJN07210"/>
        <property type="gene ID" value="CG723_35055"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013096">
        <property type="entry name" value="Cupin_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07883">
        <property type="entry name" value="Cupin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01381">
        <property type="entry name" value="HTH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="15"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN07210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="190" mass="20461" checksum="6032E6F98E348214" modified="2018-04-25" version="1">MSDLDLLTQSLGRNVKRWRTERGFTLDGLATRAGVSRGMLIQIEQARTNPSIGTVVKIGDALGISITTLLDYEQGPKVRIVPPEQAVRLWSTEGGSYNRLLAGTEAPGPLEMWDWRLEPGDGSGSDPHPAGTVELLHVTAGELTLVVDGAEYRVPAGSSVSFEADSSHTYRNDGTEAMEMTMAVSVPPVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JKF7</accession>
    <name>A0A2M9JKF7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_35355</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the sbp family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000022">
        <property type="protein sequence ID" value="PJN07267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN07267">
        <property type="protein sequence ID" value="PJN07267"/>
        <property type="gene ID" value="CG723_35355"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009709">
        <property type="entry name" value="DUF1290"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06947">
        <property type="entry name" value="DUF1290"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF018579">
        <property type="entry name" value="Sbp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="1 2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="29"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="55"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="80"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRNR" id="PIRNR018579"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN07267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="110" mass="11457" checksum="6C46E1C47CD57436" modified="2018-04-25" version="1">MIAVLGLVVGVVVGLFVRPEVPAVVEPYLPIAVVAALDAVFGGLRAMLDGIFDDKVFVVSFLSNVVVAALIVFLGDKLGVGAQLSTGVVVVLGIRIFSNAAAIRRHIFRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JL39</accession>
    <name>A0A2M9JL39_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Cystathionine gamma-lyase</fullName>
            <ecNumber evidence="4">4.4.1.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CG723_32985</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CB01635</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 3">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the trans-sulfuration enzymes family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.4.1.1" evidence="4"/>
    <dbReference type="EMBL" id="NNBL01000019">
        <property type="protein sequence ID" value="PJN07583.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN07583">
        <property type="protein sequence ID" value="PJN07583"/>
        <property type="gene ID" value="CG723_32985"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004123">
        <property type="term" value="F:cystathionine gamma-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080146">
        <property type="term" value="F:L-cysteine desulfhydrase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044540">
        <property type="term" value="F:L-cystine L-cysteine-lyase (deaminating)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044249">
        <property type="term" value="P:cellular biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019346">
        <property type="term" value="P:transsulfuration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000277">
        <property type="entry name" value="Cys/Met-Metab_PyrdxlP-dep_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11808">
        <property type="entry name" value="PTHR11808"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01053">
        <property type="entry name" value="Cys_Met_Meta_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001434">
        <property type="entry name" value="CGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00868">
        <property type="entry name" value="CYS_MET_METAB_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="2 3" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="2">
        <location>
            <position position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR001434-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU362118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PJN07583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="378" mass="40471" checksum="AF18D9F77F3037B3" modified="2018-04-25" version="1">MTQSTQIGDGTRAVRAGLPEASKNDPTLPGPVFAAHFHLPGDVSGPYTYGRDDNPTWTHLERAIGELEAPGQEDVDTLVFASGMAAISAVLFSQLKAGDMVVLPSDGYQVFPLVREQLTAFGIEVRTAPTGGDAQLDVLDGAKLLWIETPSNPGLDVCDVRRLAEAAHARGALVAVDNTLATPLGQRPLELGADFSVASGTKQLTGHGDILLGYVTCRDAELTASVRGWRKIVGAIPGPMEAWLAHRSLATLQLRAERQNANALALALALRDRDDIEGLRYPGLPDDPSHKIAAQQMRRFGCVVSFTLPTRARAEQFMESLTLVDDATSFGGVRSTAERRRRWGGDDVPEGFIRFSAGAEDPDDLVADVLRALDEAAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-05-25" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JL65</accession>
    <name>A0A2M9JL65_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Thioredoxin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">trxA</name>
        <name evidence="6" type="ORF">CG723_33155</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CB01635</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the thioredoxin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000019">
        <property type="protein sequence ID" value="PJN07615.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN07615">
        <property type="protein sequence ID" value="PJN07615"/>
        <property type="gene ID" value="CG723_33155"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015035">
        <property type="term" value="F:protein-disulfide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005746">
        <property type="entry name" value="Thioredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017937">
        <property type="entry name" value="Thioredoxin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000077">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01068">
        <property type="entry name" value="thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00194">
        <property type="entry name" value="THIOREDOXIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2 4" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="5">
        <location>
            <begin position="1"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="disulfide bond" description="Redox-active" evidence="4">
        <location>
            <begin position="33"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR000077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000077-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PJN07615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="110" mass="11809" checksum="6AA67B8D16E00EDE" modified="2018-04-25" version="1">MAGNLKNVTDASFDEDVLKSDKPVLVDFWAAWCGPCRQIAPSLEAIAAEYGDKIEVVKLNIDENPAIAAKYGVMSIPTLNVYQGGEVAKTIVGAKPKAAIVRDLEDFIAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JL78</accession>
    <name>A0A2M9JL78_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ribonuclease P protein component</fullName>
            <shortName evidence="5">RNase P protein</shortName>
            <shortName evidence="5">RNaseP protein</shortName>
            <ecNumber evidence="5">3.1.26.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Protein C5</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5 6" type="primary">rnpA</name>
        <name evidence="6" type="ORF">CG723_33195</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CB01635</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>Endonucleolytic cleavage of RNA, removing 5'-extranucleotides from tRNA precursor.</text>
            <dbReference type="EC" id="3.1.26.5"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="5">Consists of a catalytic RNA component (M1 or rnpB) and a protein subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the RnpA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.26.5" evidence="5"/>
    <dbReference type="EMBL" id="NNBL01000019">
        <property type="protein sequence ID" value="PJN07623.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN07623">
        <property type="protein sequence ID" value="PJN07623"/>
        <property type="gene ID" value="CG723_33195"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004526">
        <property type="term" value="F:ribonuclease P activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001682">
        <property type="term" value="P:tRNA 5'-leader removal"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00227">
        <property type="entry name" value="RNase_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000100">
        <property type="entry name" value="RNase_P"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33992">
        <property type="entry name" value="PTHR33992"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00825">
        <property type="entry name" value="Ribonuclease_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00188">
        <property type="entry name" value="rnpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="4 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 5" id="KW-0540">Nuclease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="1 5" id="KW-0819">tRNA processing</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PJN07623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="123" mass="13177" checksum="A7BC8D8EB6E5E374" modified="2018-04-25" version="1">MLPSENRLRRREDFATAVRRGRRAGRPLLVVHLRSGATDPHAPGESVPPTRAGFVVSKAVGGAVVRTAVKRRLRHLMRDRLALLSPGSLVVVRALPGSGDADHAELARDLDAALQRLLGGGAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JLG6</accession>
    <name>A0A2M9JLG6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CG723_32130</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CB01635</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000018">
        <property type="protein sequence ID" value="PJN07721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN07721">
        <property type="protein sequence ID" value="PJN07721"/>
        <property type="gene ID" value="CG723_32130"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="63"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="146"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="189"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="14"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PJN07721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="250" mass="26461" checksum="8BA3E974F1C2A87D" modified="2018-04-25" version="1">MTWSEMQPLLSQACWDTLYMVGWSTLIAVVAGLPLGVLLVLTDRGGLLQNAVVNKVIGQIVNIVRSMPFLILMVALMGFTRWIVGTTIGREAAIVPLAIGAIPFFARLVETSVREVDGGLIEAVQSMGGNTWTVVRKVLVPESLPSLISATTTTIIAIIGYSAMAGTVGAGGLGDLAIRYGYQRFEAELMWIIVAVLAVTIAVIQFAGDSGARVLHRRAGKGGEPLRFRAFTGLLPGGPVTADATPAKTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JLK0</accession>
    <name>A0A2M9JLK0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">AAA family ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_32190</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000018">
        <property type="protein sequence ID" value="PJN07732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN07732">
        <property type="protein sequence ID" value="PJN07732"/>
        <property type="gene ID" value="CG723_32190"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011704">
        <property type="entry name" value="ATPase_dyneun-rel_AAA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07728">
        <property type="entry name" value="AAA_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA_5" evidence="1">
        <location>
            <begin position="105"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN07732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="394" mass="41832" checksum="B32FEA00094F3590" modified="2018-04-25" version="1">MSTTTDTVQGATSAAPRQIVPPEELYSDELAFLAAYDTGPRPPGWWLTPRAVVTFVMGSGEPLRLPEGADAGEGVPRRLAVRRKFVGERALVERCVVTLAGERGLLLVGEPGTAKSMLSELLAAAVSGTSALTVQGTAGTTEDQLKYGWNYALLLAQGPSPKALVPSPVLAAMTQGAVARVEEVTRCLPEVQDALISLLSERRIAVPELAGTDAAQAHAAPGFNVIATANLRDKGVSEMSAALKRRFNFETVGPIGDFDAELDLVRRQSKAAVERAGAAYQLDDMVLDVLVTAFRELRSGRSAEGWEVERPSTVMSTAEAVSVATALGVAAAYFPGDRDALALLPGHLTGVVRKDDPADAARLLGYWDGAVRRRAEEGSATWRTLWDLRSVLEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JLN2</accession>
    <name>A0A2M9JLN2_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF2510 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CG723_32385</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000018">
        <property type="protein sequence ID" value="PJN07768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN07768">
        <property type="protein sequence ID" value="PJN07768"/>
        <property type="gene ID" value="CG723_32385"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018929">
        <property type="entry name" value="DUF2510"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10708">
        <property type="entry name" value="DUF2510"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="69"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="domain" description="DUF2510" evidence="3">
        <location>
            <begin position="5"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="91"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="297"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="38"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="99"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF10708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PJN07768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="317" mass="32574" checksum="03495874BAB1F08D" modified="2018-04-25" version="1">MTPPPGWYPDPTAPPTERWWDGAAWTEHRRQPQNTPAAPQAFGPPVEPPLPAAGPQRPPAAPGRGAKTIALAAAGIVLVASIATGAVLLGRGDDDPKSRTAPTSSAPAPTDPTATASSAEPTPTEDASTAVDQLNGITLPVLDGWQKAENVVDDDMLITTPRTYDCPGDSGLCRHGTVVSRTVTGTDETSPEVIAKRDIKDAADASYDKNGINQQPFGGIESHQQIAARQTAVAGRAGYLVRWKVKTAKGPGGYVQSVVFPSSAGSEALVTVRITVDAGQDAPPLSDMDRIVKGIRAAGDSGSDGGVGSSIGPTVTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JM78</accession>
    <name>A0A2M9JM78_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Histidine kinase</fullName>
            <ecNumber evidence="3">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CG723_30235</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CB01635</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="3"/>
    <dbReference type="EMBL" id="NNBL01000016">
        <property type="protein sequence ID" value="PJN07981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN07981">
        <property type="protein sequence ID" value="PJN07981"/>
        <property type="gene ID" value="CG723_30235"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="HAMP" evidence="9">
        <location>
            <begin position="185"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="8">
        <location>
            <begin position="246"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="395"/>
            <end position="419"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PJN07981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="452" mass="48768" checksum="A662A11C552BD4AA" modified="2018-04-25" version="1">MRPYVSWFWPRTLRGRLALVALTTATLLMVILTAVFNTVVRNRLQHQADDELHTRAAAVAATVDTSGPRVRVLETPGEELLDTNVWIYDGGRLLEKPPSAAAGPLTRAADRLAARSGRRCVTVQAHGPVRLCSLPVPDGKSDASVVTALDLSPYSSSADAMLYASLALDAVMLACTYALTRLAVGRALRPVRTMTEHAAQWSAIASEERFASVERPIELTQLGGSLDALLDRIRALLRHEQQLTRELSHELRNPLARIIAELDWWQARPRSAADTRTTHDAIADAARSMRRICDTLLDDARDSAATTRGVSDVPMVLRGLADRADTAGNVEVVVTVREPGLSAGVPGTLLERIASPLLDNALRHARSRVEIRACARAGGVRVDVTDDGPGVPESFAPQLFQPGRRARPGDGHDGAGLGLPLSRRLARSVGGEVHHDERHTPGARFVISLPAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JMD7</accession>
    <name>A0A2M9JMD7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Phosphomannomutase/phosphoglucomutase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CG723_30455</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CB01635</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the phosphohexose mutase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000016">
        <property type="protein sequence ID" value="PJN08018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08018">
        <property type="protein sequence ID" value="PJN08018"/>
        <property type="gene ID" value="CG723_30455"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016868">
        <property type="term" value="F:intramolecular transferase activity, phosphotransferases"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005844">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016055">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-I/II/III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005845">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005846">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005843">
        <property type="entry name" value="A-D-PHexomutase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036900">
        <property type="entry name" value="A-D-PHexomutase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005841">
        <property type="entry name" value="Alpha-D-phosphohexomutase_SF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02878">
        <property type="entry name" value="PGM_PMM_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02879">
        <property type="entry name" value="PGM_PMM_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02880">
        <property type="entry name" value="PGM_PMM_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00408">
        <property type="entry name" value="PGM_PMM_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00509">
        <property type="entry name" value="PGMPMM"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53738">
        <property type="entry name" value="SSF53738"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55957">
        <property type="entry name" value="SSF55957"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PGM_PMM_I" evidence="6">
        <location>
            <begin position="17"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="domain" description="PGM_PMM_II" evidence="7">
        <location>
            <begin position="165"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="domain" description="PGM_PMM_III" evidence="8">
        <location>
            <begin position="272"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="domain" description="PGM_PMM_IV" evidence="5">
        <location>
            <begin position="383"/>
            <end position="459"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PJN08018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="461" mass="48823" checksum="DD0FFBB10F0880D1" modified="2018-04-25" version="1">MTRATDATHRTDLSGLVKAYDVRGVVPDQWGEVTAELFGAAFVQVTGADAIVTGHDMRPSSPGLARAFARGATAQGADVTEIGLCSTDQLYYASGSLGLPGAMFTASHNPAQYNGIKMCRAAAEPVGQDTGLAEIRTLVEEWTDNGAPATADRTGAVTTRDTLADYATYLHSLVDLSAIRPLKVVVDAGNGMGGHTVPTVLAGLPLDIVPMYFELDGTFPNHEANPLDPANIVDLQARVRAEGADIGIAFDGDADRCFVVDENGDPVSPSAVTALVASRELARHPGATVIHNLITSRTVPEVIREAGGTPVRTRVGHSFIKREMARAGAVFGGEHSAHYYFRDFWNADTGMLAALHVLAALGTQNTPLSDLTSSFERYAASGEINSAVGDPSARTAAVRAAWSTRPDVTLDDLDGLTVSGTDWWFNVRPSNTEPLLRLNVEAPTESAMRALRDEVLATIRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JME5</accession>
    <name>A0A2M9JME5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">IclR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CG723_30685</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000016">
        <property type="protein sequence ID" value="PJN08050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08050">
        <property type="protein sequence ID" value="PJN08050"/>
        <property type="gene ID" value="CG723_30685"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014757">
        <property type="entry name" value="Tscrpt_reg_IclR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005471">
        <property type="entry name" value="Tscrpt_reg_IclR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09339">
        <property type="entry name" value="HTH_IclR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01614">
        <property type="entry name" value="IclR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00346">
        <property type="entry name" value="HTH_ICLR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51077">
        <property type="entry name" value="HTH_ICLR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51078">
        <property type="entry name" value="ICLR_ED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH iclR-type" evidence="3">
        <location>
            <begin position="11"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="domain" description="IclR-ED" evidence="4">
        <location>
            <begin position="74"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PJN08050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="273" mass="29469" checksum="D34B77A1BC8C8CB5" modified="2018-04-25" version="1">MGERTTASSASPAVGRALDILLHLAGRSGPVQAAALARELDIPRSSAYHVLSVLVDRGFVTYLPKEQAYGLGVASFEIGSAYLRHEPLERLARPILRSASARLGQTVHLGIVHGAETVYLLKERPTSTRSGDADISLVTDVGVRLPAHLTANGRAILAHASPAQLRALFPRQADLITRTGKGPRSLSELLDLLARDRARGWSEEVELVSEGFRSLGVAAFDHNERPVAALSSTWQRHYSRHDADHVREVLEQGAARLTAAMSGRRPHAGTRAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JMK9</accession>
    <name>A0A2M9JMK9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CG723_30400</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000016">
        <property type="protein sequence ID" value="PJN08101.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08101">
        <property type="protein sequence ID" value="PJN08101"/>
        <property type="gene ID" value="CG723_30400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PJN08101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="76" mass="8533" checksum="8F846467FB212B74" modified="2018-04-25" version="1">MPVECPRCAFAEISLLATSPVPGVWDVVQCGRCLYTWRTIEPARRTQRDAYPDTFKLTESDIENAIEVPAVPPLLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JMN8</accession>
    <name>A0A2M9JMN8_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Fructose-1,6-bisphosphatase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">glpX</name>
        <name evidence="7" type="ORF">CG723_29385</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CB01635</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>beta-D-fructose 1,6-bisphosphate + H2O = beta-D-fructose 6-phosphate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:11064"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:32966"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57634"/>
            <dbReference type="EC" id="3.1.3.11"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Carbohydrate biosynthesis; gluconeogenesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 4">Belongs to the FBPase class 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000015">
        <property type="protein sequence ID" value="PJN08122.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08122">
        <property type="protein sequence ID" value="PJN08122"/>
        <property type="gene ID" value="CG723_29385"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00138"/>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042132">
        <property type="term" value="F:fructose 1,6-bisphosphate 1-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006071">
        <property type="term" value="P:glycerol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01516">
        <property type="entry name" value="FBPase_glpX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004464">
        <property type="entry name" value="FBPase_class-2/SBPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30447">
        <property type="entry name" value="PTHR30447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03320">
        <property type="entry name" value="FBPase_glpX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004532">
        <property type="entry name" value="GlpX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00330">
        <property type="entry name" value="glpX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="5" id="KW-0464">Manganese</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="6">
        <location>
            <begin position="105"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="6">
        <location>
            <begin position="182"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="6">
        <location>
            <begin position="204"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="50"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="74"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="102"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="105"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="137"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="228"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="231"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR004532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR004532-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR004532-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PJN08122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="344" mass="36478" checksum="39D975EA5FE87823" modified="2018-04-25" version="1">MTEHHQLPSELEVPAEAPDRNLALELVRVTEAAAMAAGRWVGRGDKNGADGAAVRAMRTLVSTVSMNGVVVIGEGEKDEAPMLYNGERVGDGTSAEVDIAVDPIDGTTLCAKGMPNAIAVLAAADRGTMFDPSAVFYMDKLVAGPEAADYVDINAPVAVNIRRIAKAKRAAPEDVTVVILDRPRHEGIIKEVREAGARIKLISDGDVAGSVLAVREDSGIDLLLGIGGTPEGIISACAIKCLGGVIQGKLWPKDDAERQRAIDAGHDLDRVLSTNDLVSGENVFFVATGITDGELLRGVRYRAESATTSSLVMRSKSGTIRQIDSQHRLSKLRAYSAIDFDRAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JMU4</accession>
    <name>A0A2M9JMU4_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Dihydropteroate synthase</fullName>
            <shortName evidence="1">DHPS</shortName>
            <ecNumber evidence="1">2.5.1.15</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Dihydropteroate pyrophosphorylase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">folP</name>
        <name evidence="3" type="ORF">CG723_29765</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; tetrahydrofolate biosynthesis; 7,8-dihydrofolate from 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate and 4-aminobenzoate: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the DHPS family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.15" evidence="1"/>
    <dbReference type="EMBL" id="NNBL01000015">
        <property type="protein sequence ID" value="PJN08193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08193">
        <property type="protein sequence ID" value="PJN08193"/>
        <property type="gene ID" value="CG723_29765"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00077">
        <property type="reaction ID" value="UER00156"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004156">
        <property type="term" value="F:dihydropteroate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046656">
        <property type="term" value="P:folic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046654">
        <property type="term" value="P:tetrahydrofolate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00739">
        <property type="entry name" value="DHPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045031">
        <property type="entry name" value="DHP_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006390">
        <property type="entry name" value="DHP_synth_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011005">
        <property type="entry name" value="Dihydropteroate_synth-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000489">
        <property type="entry name" value="Pterin-binding_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20941">
        <property type="entry name" value="PTHR20941"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00809">
        <property type="entry name" value="Pterin_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51717">
        <property type="entry name" value="SSF51717"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01496">
        <property type="entry name" value="DHPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00792">
        <property type="entry name" value="DHPS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00793">
        <property type="entry name" value="DHPS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50972">
        <property type="entry name" value="PTERIN_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0289">Folate biosynthesis</keyword>
    <keyword evidence="1" id="KW-0460">Magnesium</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pterin-binding" evidence="2">
        <location>
            <begin position="14"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU361205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN08193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="286" mass="30776" checksum="B234A30C8A080524" modified="2018-04-25" version="1">MLRLGPREFGAHEPVIMAIVNRTPDSFYDQGSTFHDEPALTRVEQAVAEGAAIIDIGGVKAGPGDEVSAQEEARRTVGFVAEVRRRFPDVVISVDTWRHDVGEAVCEAGADVLNDAWGGVDPKLAEVAARYGKGLVCTHAGGAEPRTRPHRVAYDDVMADILDVTVGLAERAVALGVPRESVLIDPGHDFGKNTRHSLEATRRLGEMVETGWPVLVSLSNKDFVGETLDRPVKERVIGTLATTAVSAWLGAQVYRVHEVAETRQVLDMVATIAGHRPPAVARRGLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JMV6</accession>
    <name>A0A2M9JMV6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Suppressor of fused domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_29850</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000015">
        <property type="protein sequence ID" value="PJN08208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08208">
        <property type="protein sequence ID" value="PJN08208"/>
        <property type="gene ID" value="CG723_29850"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020941">
        <property type="entry name" value="SUFU-like_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05076">
        <property type="entry name" value="SUFU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SUFU" evidence="1">
        <location>
            <begin position="29"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN08208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="198" mass="20823" checksum="DF40DA064729AE23" modified="2018-04-25" version="1">MGDVLALVEARLRTALGEPDARAAVTFLGTDRIEVLRFTDAADTGLVRYATLGMSAAPMADPTSALADPLKGPRAELVLSVRTGRADTDKVLRPLAVLAASPQVEGVVVAAGASLDVGEPLWPGAPFTSVLVAGSGGLVEDLELDDPLDPVRFLPLLPMTQNEAAWKRVHGAAALEEKWLNSGTDLRDPLRKSVPLDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JN07</accession>
    <name>A0A2M9JN07_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_30080</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000015">
        <property type="protein sequence ID" value="PJN08251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08251">
        <property type="protein sequence ID" value="PJN08251"/>
        <property type="gene ID" value="CG723_30080"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.150.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018766">
        <property type="entry name" value="Zinicin_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042271">
        <property type="entry name" value="Zinicin_2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39420">
        <property type="entry name" value="PTHR39420"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10103">
        <property type="entry name" value="Zincin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03624">
        <property type="entry name" value="TIGR03624"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="96"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="449"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="462"/>
            <end position="490"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN08251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="490" mass="51765" checksum="2A026285776CB184" modified="2018-04-25" version="1">MSDTPFGFGLPPEEPDDGDEGKKKDQQGGGGQGPANPFGFGGMPGMGGGDNPFAAMFGSLNPNDLGAAFQQLGQMLSYEGGPVNWEMAKDIARQTVSQGTADGTKDASVGPAERSQVEEAVRLADLWLDDATSLPSGAGSAVAWSRAEWVEATLPVWKELVDPVAERVGLAMGDVLPEEMQAMAGPLIGMMRSMGGAMFGSQIGQAVGVLAGEVVGSTDIGLPLGPAGKAALLPVNIEAFGKDLGIPKEEVRLYLALREAAHQRLFSHVPWLRSHLFGAVEGYARGIKVDTAKLEDAVGQLDPQNPEQLQEALQQGMFQPEDTPEQKAALARLETALALVEGWVDAVVHAAAKPRLSSADALRETLRRRRATGGPAEQTFATLIGLELRPRRLRDASRLWASLTDARGVDGRDGLWAHPDMLPTASDLDDPDGFVHREQLDFSEIDKMLGEAASGGLDKPNLSKEGDSKGDGPADSSKNDSDGSKDDEGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-05-25" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JN89</accession>
    <name>A0A2M9JN89_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Tyrosinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_28460</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000014">
        <property type="protein sequence ID" value="PJN08325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08325">
        <property type="protein sequence ID" value="PJN08325"/>
        <property type="gene ID" value="CG723_28460"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1280.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008922">
        <property type="entry name" value="Di-copper_centre_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002227">
        <property type="entry name" value="Tyrosinase_Cu-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00264">
        <property type="entry name" value="Tyrosinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00092">
        <property type="entry name" value="TYROSINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48056">
        <property type="entry name" value="SSF48056"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00497">
        <property type="entry name" value="TYROSINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00498">
        <property type="entry name" value="TYROSINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyrosinase_Cu-bd" evidence="1">
        <location>
            <begin position="55"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosinase_Cu-bd" evidence="2">
        <location>
            <begin position="219"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS00497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS00498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN08325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="285" mass="32274" checksum="817C05A48DAEF9A1" modified="2018-04-25" version="1">MVYTRQNQSALTAAQKKRFVSALLAIKRSGQYDEFVRLHVEFYVGDGDGGQRVAHMASTFLPWHRQFLLEFEGALQRVDPGVSVPYWDWTVDRSPTSSLWGEGFLGGNGRRSDRRVTTGPFAYGSGHWPIKEGVTEGEYLTRDFGRPHDPIELPTKDELAWAMQDALYDSAPWNSTSSRGFRNKVEGWTSGVGNGKFRNHNRVHRWVGGHMLGADAVNDPVFWLNHAFVDLLWSRWHRNYPDSAPYLPAGGTTGTGRVVTLDELMPPWKVKPSSLIEHGHLYRYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JNE3</accession>
    <name>A0A2M9JNE3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CG723_28800</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000014">
        <property type="protein sequence ID" value="PJN08385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08385">
        <property type="protein sequence ID" value="PJN08385"/>
        <property type="gene ID" value="CG723_28800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PJN08385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="105" mass="11177" checksum="C437DD260BD315EC" modified="2018-04-25" version="1">MKDPMTTVPCTVNQWSVPLRELLCPAAWYGARRFTEAGAGTTAGPSHAQTPRAARGAALPREGGVMAAFCRLPAYVRQLCGPRQGVTQMTCAFVKGRAGSAARRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JNX9</accession>
    <name>A0A2M9JNX9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CG723_27810</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CB01635</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000013">
        <property type="protein sequence ID" value="PJN08576.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08576">
        <property type="protein sequence ID" value="PJN08576"/>
        <property type="gene ID" value="CG723_27810"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015205">
        <property type="term" value="F:nucleobase transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006043">
        <property type="entry name" value="NCS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006042">
        <property type="entry name" value="Xan_ur_permease"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00860">
        <property type="entry name" value="Xan_ur_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01116">
        <property type="entry name" value="XANTH_URACIL_PERMASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="38"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="72"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="95"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="120"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="160"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="186"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="310"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="334"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="371"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="399"/>
            <end position="419"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PJN08576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="439" mass="45081" checksum="86451F4A984CBF94" modified="2018-04-25" version="1">MDESRPLGRILLFGIQHVLVMAATPISAIFLMSATLGLSAGLTVDLLSAAFVLSGVGSLIQSLGPWKFGPRLPFVMLPGGAPLILFLAIAEQHGVRIATGAVVLTAVFSFVVLPVFSRLLAYFPALVIGTMIVIVGVNLVKVGAVLVTGQPGSPGFANPTNLGLGMATIGFTVVFYLLFTGILRQLAVMLGLFAGTALAAAVGAIDGAGATGGALVNLPHLMPFGSPEFNLVAALPLMLYSLASMAEATGQTVINAEAVGKKIDKRTDVPKTVRGDALTSLFGGFFGLPLMVTSGENIGIVRVTGVRSRFVTAAAGVILIIIGFLAPVTRAISVIPTAVVGGTAMVVFAVITVLGIQMLGRSDLDKHTSTFICAVALALGLLPILVPGVYGAFPPNVRILLESGVAVGTFTAAVLNILFHHVRPGVAARLTTARAEGDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JP66</accession>
    <name>A0A2M9JP66_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alpha/beta hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_26405</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000012">
        <property type="protein sequence ID" value="PJN08635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08635">
        <property type="protein sequence ID" value="PJN08635"/>
        <property type="gene ID" value="CG723_26405"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000639">
        <property type="entry name" value="Epox_hydrolase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00111">
        <property type="entry name" value="ABHYDROLASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00412">
        <property type="entry name" value="EPOXHYDRLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="35"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN08635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="286" mass="31832" checksum="8233E8F13034F881" modified="2018-04-25" version="1">MVRRIDVTGAGGVSLAAWEFADPPKTGEVDQSPGVLLLHGLMGRASHWANTARWLSERHRAVALDQRGHGQSQKPPEGPYDREAYVQDAEAALVQLGLAPAVVIGHSMGALTAWQLAARRPDLVRAVIICDMRASALGAASQREWEDWFDAWPLPFATLGDVRKWFGEDDPWVERPQPSRGEFYAEVMAESPDGWRPVFDHRQMLVSRATWVYDAHWEELAQVRCPTLVVRGLDGELGRAESQEMVRVLPRGEYAEIADAGHLVHYDRPEALRSAIEPFLDGVLTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JPX6</accession>
    <name>A0A2M9JPX6_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 6">Lon protease</fullName>
            <ecNumber evidence="5 6">3.4.21.53</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">ATP-dependent protease La</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5 13" type="primary">lon</name>
        <name evidence="13" type="ORF">CG723_25960</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">CB01635</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5 6 9">
            <text>Hydrolysis of proteins in presence of ATP.</text>
            <dbReference type="EC" id="3.4.21.53"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="5 6">Homohexamer. Organized in a ring with a central cavity.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5 6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="induction">
        <text evidence="5">By heat shock.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5 6 9 10">Belongs to the peptidase S16 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.53" evidence="5 6"/>
    <dbReference type="EMBL" id="NNBL01000011">
        <property type="protein sequence ID" value="PJN08932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08932">
        <property type="protein sequence ID" value="PJN08932"/>
        <property type="gene ID" value="CG723_25960"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004176">
        <property type="term" value="F:ATP-dependent peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034605">
        <property type="term" value="P:cellular response to heat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006515">
        <property type="term" value="P:protein quality control for misfolded or incompletely synthesized proteins"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.130.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01973">
        <property type="entry name" value="lon_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027543">
        <property type="entry name" value="Lon_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004815">
        <property type="entry name" value="Lon_bac/euk-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008269">
        <property type="entry name" value="Lon_proteolytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027065">
        <property type="entry name" value="Lon_Prtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003111">
        <property type="entry name" value="Lon_prtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046336">
        <property type="entry name" value="Lon_prtase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008268">
        <property type="entry name" value="Peptidase_S16_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10046">
        <property type="entry name" value="PTHR10046"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05362">
        <property type="entry name" value="Lon_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02190">
        <property type="entry name" value="LON_substr_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001174">
        <property type="entry name" value="Lon_proteas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00464">
        <property type="entry name" value="LON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="SSF88697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00763">
        <property type="entry name" value="lon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51787">
        <property type="entry name" value="LON_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51786">
        <property type="entry name" value="LON_PROTEOLYTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01046">
        <property type="entry name" value="LON_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at transcript level"/>
    <keyword evidence="5 6 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 6 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 6 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2 5 6" id="KW-0645">Protease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5 6" id="KW-0720">Serine protease</keyword>
    <keyword evidence="4 5" id="KW-0346">Stress response</keyword>
    <feature type="domain" description="Lon N-terminal" evidence="12">
        <location>
            <begin position="10"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="domain" description="Lon proteolytic" evidence="11">
        <location>
            <begin position="611"/>
            <end position="795"/>
        </location>
    </feature>
    <feature type="active site" evidence="5 7 9">
        <location>
            <position position="701"/>
        </location>
    </feature>
    <feature type="active site" evidence="5 7 9">
        <location>
            <position position="744"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5 8">
        <location>
            <begin position="369"/>
            <end position="376"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR001174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR001174-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR001174-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PJN08932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="804" mass="86452" checksum="8E78191E220754AA" modified="2018-04-25" version="1">MASTSTPLTLPVLPLDDEVVLPGMVVPLDLNDNDVRAAVEAAQAAARSSGSVGGSKPKVLLVPRIDGTYANTGVLGTVEQVGRLADGDPGALIRGRSRVRIGAGTTGPGAALWVEGLAVEETVPEPLPGSVTELVTEYKALATNWLKKRGAWQVVDRVQQIDDVSALADNSGYSPFLSTPQKVELLETADPVARLKLATEQLREHLAEQDVAESIAKDVQEGVDKQQREFLLRRQLDAVRKELRELNGESEGEESDDYRTRVEAADLPERVREAALKEVEKLERSSDQSPEGSWIRTWLDTVLELPWNERTEDEYDIQGAQSVLDAEHSGLEDVKERITEYLAVRKRRSERGLGVVGGRRGGAVLALVGPPGVGKTSLGESVAHAMGRKFVRVALGGVRDEAEIRGHRRTYVGALPGRIVRAIKEAGSMNPVVLLDEIDKVGSDFRGDPAAALLEVLDPAQNHTFRDHYLEVELDLSDVVFLATANVLEAIPEALLDRMELVRLDGYTEDEKVVIARDHLLPRQLERAGLDKGEVTLDESALRKLAGEYTREAGVRNLERSVARLLRKVAAQHELGERELPFTVEDTDLRSLIGRPHHVPEAAQDPAERRTAVPGVATGLAVTGAGGDVLYVEASLADPETGAAGLTLTGQLGDVMKESAQIALSFLRSHGAELELPVADLKDRGVHIHFPAGAVPKDGPSAGVTMTTALASLLSGRQVRTDVAMTGEVSLTGRVLPIGGVKQKLLAAHRAGITTVVIPKRNEADLDDVPAEVLEKLDVHPVTDVRQVLELALAPAALEVTVAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JPZ3</accession>
    <name>A0A2M9JPZ3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Multi-component regulatory system-8</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_25930</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000011">
        <property type="protein sequence ID" value="PJN08926.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08926">
        <property type="protein sequence ID" value="PJN08926"/>
        <property type="gene ID" value="CG723_25930"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007995">
        <property type="entry name" value="DUF742"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36221">
        <property type="entry name" value="PTHR36221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05331">
        <property type="entry name" value="DUF742"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN08926.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="143" mass="15515" checksum="C5715F59885CF4F4" modified="2018-04-25" version="1">MSSSSSVTNLSTGGPKLPTRGGDRKPARVRPYSLTGGRTRFGHVLLVETFVAALEAPEERLEIGQGTLSTRIMPEMRAIVELCRRMRTVAEIAALLKMPLGVVRVLLSDLADQGKIRVYGTGHGPGQPDRALLERVLSGLRRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JQB8</accession>
    <name>A0A2M9JQB8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_24245</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000010">
        <property type="protein sequence ID" value="PJN09045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN09045">
        <property type="protein sequence ID" value="PJN09045"/>
        <property type="gene ID" value="CG723_24245"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029046">
        <property type="entry name" value="LolA/LolB/LppX"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89392">
        <property type="entry name" value="SSF89392"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014644128" evidence="1">
        <location>
            <begin position="30"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN09045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="292" mass="30365" checksum="1C3BF54C2631ABD7" modified="2018-04-25" version="1">MVQHGRAARAVAAAAAVGVMGLTTGCSAAAEADNESPADSAAAVHDAADRLVREGSSKARTSMEMASGGTRVTIRGEGVYDYRARVGQLKVVLPQDPSGAEEHRPITELLAPGALYMKNRGAGVPADKWVRVETASMADGNLVTGGATDPLAAAELLRGARKVTYVGESELAGTVVRHYRGTVDMAAAAHAASPASRQSLTAAAKGFAKDQVPFDVYLDDEGRIRKVRHRFSFVNTTKVTTAVKGNGKGKGQGGKRDVVDVASTTLLYGFGVTANIELPDTKDIFAGKIAEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JQH2</accession>
    <name>A0A2M9JQH2_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Cysteine--tRNA ligase</fullName>
            <ecNumber evidence="11">6.1.1.16</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Cysteinyl-tRNA synthetase</fullName>
            <shortName evidence="11">CysRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">cysS</name>
        <name evidence="13" type="ORF">CG723_24725</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">CB01635</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>ATP + L-cysteine + tRNA(Cys) = AMP + diphosphate + L-cysteinyl-tRNA(Cys)</text>
            <dbReference type="Rhea" id="RHEA:17773"/>
            <dbReference type="Rhea" id="RHEA-COMP:9661"/>
            <dbReference type="Rhea" id="RHEA-COMP:9679"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:35235"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78517"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.16"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="11">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 11">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.16" evidence="11"/>
    <dbReference type="EMBL" id="NNBL01000010">
        <property type="protein sequence ID" value="PJN09122.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN09122">
        <property type="protein sequence ID" value="PJN09122"/>
        <property type="gene ID" value="CG723_24725"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004817">
        <property type="term" value="F:cysteine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006423">
        <property type="term" value="P:cysteinyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00672">
        <property type="entry name" value="CysRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00041">
        <property type="entry name" value="Cys_tRNA_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015803">
        <property type="entry name" value="Cys-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015273">
        <property type="entry name" value="Cys-tRNA-synt_Ia_DALR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024909">
        <property type="entry name" value="Cys-tRNA/MSH_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032678">
        <property type="entry name" value="tRNA-synt_1_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10890">
        <property type="entry name" value="PTHR10890"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09190">
        <property type="entry name" value="DALR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01406">
        <property type="entry name" value="tRNA-synt_1e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00983">
        <property type="entry name" value="TRNASYNTHCYS"/>
    </dbReference>
    <dbReference type="SMART" id="SM00840">
        <property type="entry name" value="DALR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="SSF47323"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00435">
        <property type="entry name" value="cysS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 11" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="8 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 11 13" id="KW-0436">Ligase</keyword>
    <keyword evidence="5 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9 11" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 11" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="DALR_2" evidence="12">
        <location>
            <begin position="341"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'HIGH' region" evidence="11">
        <location>
            <begin position="31"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'KMSKS' region" evidence="11">
        <location>
            <begin position="264"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="29"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="208"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="233"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="237"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="267"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PJN09122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="466" mass="51967" checksum="C7961B84706DC6E3" modified="2018-04-25" version="1">MTIRLHDTSARKIRDFVPLTPGCVSIYLCGATVQAAPHIGHIRSGLNFDIMRRWFTYRGYEVTFVRNVTDIDDKIIKKAAEQGRPWWSIGYENERAFNDGYTALGCLPPTYEPRATGHVTEMVEMMRGLIERGHAYEADGNVYFDVRSFPGYLELSNQDLDELRQPSGDGETGKRDPRDFAMWKAVKPGEPSWETPWGRGRPGWHLECSAMAHKYLGSAFDIHGGGIDLIFPHHENEIAQAKAFGDEFAKYWVHNSWVTMSGEKMSKSLGNSVLVSEMVKDWRPIVLRYYLGTPHYRSTIEYSEEALRDAESAFARIEGFVQRVTELAGGVVAPADEVPPAFAEAMDDDLGVPQALAIIHTTVRQGNSALAADDKEAAVARLAEVRAMLGVLGLDPLDPHWAGETERGEDLHGAVDTLVRLVLEQRESARARKDWSTADAIRDQLGQSGLVIEDSPTGPRWTLGPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JQQ6</accession>
    <name>A0A2M9JQQ6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Calcium-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_25180</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000010">
        <property type="protein sequence ID" value="PJN09204.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN09204">
        <property type="protein sequence ID" value="PJN09204"/>
        <property type="gene ID" value="CG723_25180"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043761">
        <property type="entry name" value="DUF5707"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18968">
        <property type="entry name" value="DUF5707"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014967906" evidence="1">
        <location>
            <begin position="26"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN09204.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="287" mass="29873" checksum="893C66A347D485B6" modified="2018-04-25" version="1">MRIRATVAAATISGALALTAFAVPAAQAGTGTASDLNKPSAAQRFAAEAPAKHMSAFAAEAEPVVSNVTVNSGQDVVLGTTNLKTFTVSLTASHASGIQDAYIDLWHGSDVDHVDGYLPPNEDAATCTAASATTSTCKLTITVDPRGDLANSLAGSWHVTAGALAGDGSIYWDDYYGKRSVKRYSKLTTNASPEPVKKGKTITVTGSLTRANWDTSKYMGYTKQPVKLQFKKKGASTYSTVKTVTSSSTGGLKTTVTAASDGYWRYNFAGTSTTPAVASTSDFVDVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JQR4</accession>
    <name>A0A2M9JQR4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PPOX class F420-dependent enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_25240</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000010">
        <property type="protein sequence ID" value="PJN09216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN09216">
        <property type="protein sequence ID" value="PJN09216"/>
        <property type="gene ID" value="CG723_25240"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019965">
        <property type="entry name" value="PPOX_F420-dep_Rv2061_put"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011576">
        <property type="entry name" value="Pyridox_Oxase_put"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01243">
        <property type="entry name" value="Putative_PNPOx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03666">
        <property type="entry name" value="Rv2061_F420"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Putative_PNPOx" evidence="1">
        <location>
            <begin position="15"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN09216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="134" mass="14983" checksum="51C6533AD10E0BBD" modified="2018-04-25" version="1">MTTEPTSPVLAPLVKQYTVLLTSHKKDGTGVGTPVNLVVEGDHAYFRTYGKAWKVKRLRRNPEVEIAPSTLRGAPTGPEFKARVRLLDEGGEEAKHAAKLLRHKHPVMHGVAVPLAHKVQRDRTLHYEVRVLEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JQV8</accession>
    <name>A0A2M9JQV8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Carbamoylsarcosine amidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_23175</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000009">
        <property type="protein sequence ID" value="PJN09258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN09258">
        <property type="protein sequence ID" value="PJN09258"/>
        <property type="gene ID" value="CG723_23175"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.850">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000868">
        <property type="entry name" value="Isochorismatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036380">
        <property type="entry name" value="Isochorismatase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00857">
        <property type="entry name" value="Isochorismatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52499">
        <property type="entry name" value="SSF52499"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Isochorismatase" evidence="1">
        <location>
            <begin position="30"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN09258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="224" mass="23163" checksum="5E22FD2E281B321C" modified="2018-04-25" version="1">MSSGLYGRTTDDTYEQAGFGAPVQRGNRPVILVVDLTRGFTEDGYATGSDLTDVVKSTTRLIEAGRPADVPVVFTAISYTRAEAAGDSVTWLRKAPGMRSLVDGSDAVALDPRLPWQPGQDHLVVKKGASAFFGTGLAATLTGLGCDTVLVCGATTSGCVRATAVDAVQSGFPVLVPRDCVGDRADGPAQAALFDIQAKYGDVIGLDDAVGYLAALPTSRLPAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JQY2</accession>
    <name>A0A2M9JQY2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Aldehyde dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CG723_23375</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CB01635</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000009">
        <property type="protein sequence ID" value="PJN09296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN09296">
        <property type="protein sequence ID" value="PJN09296"/>
        <property type="gene ID" value="CG723_23375"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016620">
        <property type="term" value="F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="SSF53720"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00687">
        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldedh" evidence="5">
        <location>
            <begin position="15"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="499"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PJN09296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="518" mass="54867" checksum="A1D40CCDF7ABA427" modified="2018-04-25" version="1">MTAIDHKAFFINGSWRAADGTDRFDVISPRSEQRIGSAPAASKADIDAAVAAARHAFDEGEWPRLTPAERADHLSRLADGIERRRTELAELITEELGCTLFLSHIYQTVSPVMSLNYSAEIGRSLQTAEVRVSDLSRLGGESAGGGIIPMAGSSLVVKEPVGVVACFPAYNFALPAIGQKAGPALIAGCTVVVKVTEPNPLALFVVGEICEEIGLPPGVLNIVAARAPESEYLVRHPGVDMVSFTGSVDVGARIAAACGELIRPCVLELGGKSAAIVLEDAKLEDVLPVLVGASVGTNAGQSCVAQTRLLVPESQYRAYAEALADAFASLKLGDPMDAETAVGPLVTSRQRERVEYYVDVARKEGATIAHGGRRPAHLSRGWYYEPTLVTDAHNGMRVSREEIFGPVTSLIPHRGEDDAVRIANDSELGLAGSVFTADTAHGFEVARRVRTGTFSVNTFAADLGSPFGGFKKSGLGREHGPDAVQEYLVTKTISIDPSRHLPESVTRNVPRGTGPGAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JR99</accession>
    <name>A0A2M9JR99_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Phytanoyl-CoA dioxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_23895</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000009">
        <property type="protein sequence ID" value="PJN09372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN09372">
        <property type="protein sequence ID" value="PJN09372"/>
        <property type="gene ID" value="CG723_23895"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008775">
        <property type="entry name" value="Phytyl_CoA_dOase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05721">
        <property type="entry name" value="PhyH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="235"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN09372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="257" mass="28665" checksum="B9638CA34148E272" modified="2018-04-25" version="1">MATNGTLGELVTPALREQYESEGYFVLENVLSEEQLELLRGGAQYSIDRLDAEMDAAGVDTIGINHRGKRYFSNMIYQHRPELRAFLFSELTAEICRATIGEEAYLFWEQYVIKAGDPDTAFSWHQDSGYVHEDHEPYVTVWIALDDVTMDNGPVHLLPYSRSGVKSYVKHITDPVSNDRVCYFGSDPGMPMTAPAGSVVVFSSVVMHRSGPNLTDRNRRVYIAQYSKDVITLKDAPDTPQGATDPFLSGGENVADL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JRJ1</accession>
    <name>A0A2M9JRJ1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_22080</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000008">
        <property type="protein sequence ID" value="PJN09464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN09464">
        <property type="protein sequence ID" value="PJN09464"/>
        <property type="gene ID" value="CG723_22080"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="25"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN09464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="64" mass="6745" checksum="A2F0B7F951928F14" modified="2018-04-25" version="1">MNTATVGLAAGMALGFAGYFGGFWAFLLVAVLGAVGLVVGLVLQGDADVLFTRRQRDLSTRRQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JRQ0</accession>
    <name>A0A2M9JRQ0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Protein lplB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CG723_22645</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CB01635</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000008">
        <property type="protein sequence ID" value="PJN09543.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN09543">
        <property type="protein sequence ID" value="PJN09543"/>
        <property type="gene ID" value="CG723_22645"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="35"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="100"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="136"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="244"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="288"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="96"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PJN09543.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="323" mass="36591" checksum="4A24160EA4B166F3" modified="2018-04-25" version="1">MTGSQPRTGAPPDPPPDKKLPSGRRSWRRSLHRDWQLYSLAVLPILFFLVFRYLPMIGNVIAFRRFEPGGSILGEEWVGLRYVQMFLSDPSFWQVFRNTLWMGLLTLLFCFPVPIVLALLLNEVRRTALKRFVQSISYLPHFLSIVIVAGITVQMLASDGPINHMLTTFGHDPVRFIQEPGWFRTIYVGSEVWQTAGWGTILYLAALSTIDEDLYEAARIDGANRWQQTWHVTLPGIRPTMITLLILNIGTFMVVGFEKILLLYNPLTYPTADVISTYLYRTGVESNSFSYAAAIGLFEAVIGLVLITSANRLSRKTVGTSLW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JRW7</accession>
    <name>A0A2M9JRW7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">FAD-dependent oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_22945</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000008">
        <property type="protein sequence ID" value="PJN09592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN09592">
        <property type="protein sequence ID" value="PJN09592"/>
        <property type="gene ID" value="CG723_22945"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016156">
        <property type="entry name" value="FAD/NAD-linked_Rdtase_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028202">
        <property type="entry name" value="Reductase_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14759">
        <property type="entry name" value="Reductase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55424">
        <property type="entry name" value="SSF55424"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyr_redox_2" evidence="1">
        <location>
            <begin position="9"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="domain" description="Reductase_C" evidence="2">
        <location>
            <begin position="336"/>
            <end position="413"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN09592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="455" mass="48033" checksum="18DDB8B9D3F97E55" modified="2018-04-25" version="1">MPGDLEDGRIVIVGASLAGLRAAEALREEGFTGSLTVVGDEPHPPYDRPPLSKQVLLGQATADTTGLPMRRDPDAEWRLGVRATGVDLLAKQVLLEDGESLPYDRLLITTGTRARPWPNQDEGALDGVFTLRTREDGAGLAERLAAGPERVLVIGGGFTGSEIASACRERGLEVTVAERGPAPLVGALGGTLGKLAAAMQRNHGVDLRTGVTVTALHGNGSFTGADLSDGSRVDADVCVVALGAIRNVEWLAESGLAAGPRGIACDAGCRAFNMYGIVTDDVFAAGDVSRFPHPLFGYQMLSLEHWGNAVEQAEVAAHNMVNPGPLRRPHLAIPTFWSTQFGLNIKSVGVPTYSDHVVIAQGSLEARRLAMVYGYQGRVTAAVTVDMAKSLDYYRHLIETAAPFPPPPGAADRAIAAEVPIPSDVPDPSVLSHGPTVALTGYLPDRRLTVVQPMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JRY9</accession>
    <name>A0A2M9JRY9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Sugar ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CG723_22650</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CB01635</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000008">
        <property type="protein sequence ID" value="PJN09636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN09636">
        <property type="protein sequence ID" value="PJN09636"/>
        <property type="gene ID" value="CG723_22650"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="78"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="109"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="140"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="182"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="256"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="74"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PJN09636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="290" mass="31742" checksum="A280BE592938AF1A" modified="2018-04-25" version="1">MTGPTRGYRVFQGFNAVILTLVVVVTLYPIINIVARSFSGEHQIRAGEVTLWPKGFNLTTYRIVFQDGTFWRSYGNTVLYTVLSTAVAMALTTIYAYVLSKKDLRGRTFLVGIAVFTMFFSGGLIPNYVLITSLGLKNSIWAIALPNAISVFNLLVMKAFFENMPAELEEAAQIDGLSTYGTLLRIVLPLSKAVIATMVLFYSVSFWNSWFSAFLYMDRADLMPVTVYLRNLIAGATEGGNAGAAADQLTQAAANIQSVTIVLTALPILAVYPFVQRYFVSGVMLGAVKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JS43</accession>
    <name>A0A2M9JS43_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">D-alanine--D-alanine ligase</fullName>
            <ecNumber evidence="7">6.3.2.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">D-Ala-D-Ala ligase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">D-alanylalanine synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">ddl</name>
        <name evidence="11" type="ORF">CG723_21065</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CB01635</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Cell wall formation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>ATP + 2 D-alanine = ADP + D-alanyl-D-alanine + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:11224"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57416"/>
            <dbReference type="ChEBI" id="CHEBI:57822"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.2.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="8">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="8">Binds 2 magnesium or manganese ions per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="7">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the D-alanine--D-alanine ligase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.4" evidence="7"/>
    <dbReference type="EMBL" id="NNBL01000007">
        <property type="protein sequence ID" value="PJN09695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN09695">
        <property type="protein sequence ID" value="PJN09695"/>
        <property type="gene ID" value="CG723_21065"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008716">
        <property type="term" value="F:D-alanine-D-alanine ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00047">
        <property type="entry name" value="Dala_Dala_lig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000291">
        <property type="entry name" value="D-Ala_lig_Van_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005905">
        <property type="entry name" value="D_ala_D_ala"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011095">
        <property type="entry name" value="Dala_Dala_lig_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011127">
        <property type="entry name" value="Dala_Dala_lig_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07478">
        <property type="entry name" value="Dala_Dala_lig_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01820">
        <property type="entry name" value="Dala_Dala_lig_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039102">
        <property type="entry name" value="Ddl/VanB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="SSF52440"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01205">
        <property type="entry name" value="D_ala_D_alaTIGR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00843">
        <property type="entry name" value="DALA_DALA_LIGASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00844">
        <property type="entry name" value="DALA_DALA_LIGASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 7" id="KW-0133">Cell shape</keyword>
    <keyword evidence="6 7" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 7 11" id="KW-0436">Ligase</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8" id="KW-0464">Manganese</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 7" id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-grasp" evidence="10">
        <location>
            <begin position="165"/>
            <end position="375"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR039102-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PJN09695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="385" mass="41735" checksum="2BF9FD5BE5D0BF3D" modified="2018-04-25" version="1">MSSENLPQSSRPSGQKPRVAVVFGGRSSEHGVSVVTAGAVLRAIDRTKYDVLPIGITREGRWALTADDPERMAIADRKVPDVAELTESAEGGVVLPVDPSSREVVYTEPGSVPKALGDVDVVFPVLHGPYGEDGTIQGLLDLSGTPYVGCGVLSSAVGQDKDYMKRVFTSFGLKVGPYLVIRPREWEQDREGARRRVADFVGEQGWPLFIKPARAGSSIGITKVDSFEGLDEAIEEARSHDPKIIVEAALVGREIECGVLEFEDGPRASVPAEIPPVQAHDFYDFEAKYIDSASGIVPAPLTDEQTAEVQRLAVEAFDAASCEGLVRADFFLTEDGEFVINEINTLPGFTPISMYPRMWQESGVSYPELVDRLIQAALNRSTGLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JSD1</accession>
    <name>A0A2M9JSD1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CG723_21500</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CB01635</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000007">
        <property type="protein sequence ID" value="PJN09774.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN09774">
        <property type="protein sequence ID" value="PJN09774"/>
        <property type="gene ID" value="CG723_21500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="27"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="88"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="118"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="174"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="280"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="84"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PJN09774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="308" mass="33920" checksum="CB314915DE3ABBBB" modified="2018-04-25" version="1">MTTVTDTPAAPPAVKTARPPRKRGRLVPYWLLLPGLLWLVVFFALPMVYQASTSIQTGSLEDGFKVTWHFATYWDALADYWPQFLRSVLYAGAATILCLALGYPLAYLIAFRAGRWRNVVLILVIAPFFTSFLIRTLAWKTILSDSGPVVSTLNALHILDVTSWIGMTDGDRVLATPLAVICGLTYNFLPFMILPLYTSLERIDGRLHEAAGDLYASPATTFRKVTFPLSMPGVVSGTLLTFIPAAGDYVNADLLGSTDTRMVGNVIQTQFLRILDYPTAAALSFILMAAILIMVTVYIRRSGTEDLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JSL8</accession>
    <name>A0A2M9JSL8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">TetR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_19215</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000006">
        <property type="protein sequence ID" value="PJN09874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN09874">
        <property type="protein sequence ID" value="PJN09874"/>
        <property type="gene ID" value="CG723_19215"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004111">
        <property type="entry name" value="Repressor_TetR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02909">
        <property type="entry name" value="TetR_C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="29"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="52"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN09874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="244" mass="26776" checksum="FBFB1B6B6AA64E64" modified="2018-04-25" version="1">MAAQKKGDEGLVEPSLWERLERPAPARATLTLERIAAAAVEIADAEGAAAVTMRRLATQLGVAPMAAYRHVSGKDDLWALMTDRVSAELSVPPEVAGWREVLRSFAVQTRELMLRHPWMGQVPTPLISLTPARMAVAERQLEVLATTGLDADSMMAAFRTVSSYVHGATQSELALREYKERHGWSSGAETRQALAPQMNYLMDTGRYPNYQRYGLGAAHKDDPTWEFDLGLDCILDGIAARLGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JSN3</accession>
    <name>A0A2M9JSN3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_19270</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000006">
        <property type="protein sequence ID" value="PJN09885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN09885">
        <property type="protein sequence ID" value="PJN09885"/>
        <property type="gene ID" value="CG723_19270"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014832022" evidence="2">
        <location>
            <begin position="29"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="83"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN09885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="114" mass="10395" checksum="282FCEB43DA56C32" modified="2018-04-25" version="1">MKQSAVKTLGVAALGAAFAAAGAGAASAAPALPDAGSALDTVTSTLPAEQVAQVLPAGGTESLTAGKNAVAGGLKAATPAVTKALPTNGSDPVSGLLGGLPVKSLPAGGALPVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JSY4</accession>
    <name>A0A2M9JSY4_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 14">Inosine-5'-monophosphate dehydrogenase</fullName>
            <shortName evidence="7">IMP dehydrogenase</shortName>
            <shortName evidence="7">IMPD</shortName>
            <shortName evidence="7">IMPDH</shortName>
            <ecNumber evidence="7 14">1.1.1.205</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">guaB</name>
        <name evidence="16" type="ORF">CG723_19995</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">CB01635</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7 14">
            <text>H2O + IMP + NAD(+) = H(+) + NADH + XMP</text>
            <dbReference type="Rhea" id="RHEA:11708"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57464"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
            <dbReference type="EC" id="1.1.1.205"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </cofactor>
    </comment>
    <comment type="activity regulation">
        <text evidence="7">Mycophenolic acid (MPA) is a non-competitive inhibitor that prevents formation of the closed enzyme conformation by binding to the same site as the amobile flap. In contrast, mizoribine monophosphate (MZP) is a competitive inhibitor that induces the closed conformation. MPA is a potent inhibitor of mammalian IMPDHs but a poor inhibitor of the bacterial enzymes. MZP is a more potent inhibitor of bacterial IMPDH.</text>
    </comment>
    <comment type="pathway">
        <text evidence="7 14">Purine metabolism; XMP biosynthesis via de novo pathway; XMP from IMP: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7 13">Belongs to the IMPDH/GMPR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.205" evidence="7 14"/>
    <dbReference type="EMBL" id="NNBL01000006">
        <property type="protein sequence ID" value="PJN10006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN10006">
        <property type="protein sequence ID" value="PJN10006"/>
        <property type="gene ID" value="CG723_19995"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00601">
        <property type="reaction ID" value="UER00295"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003938">
        <property type="term" value="F:IMP dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006177">
        <property type="term" value="P:GMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00381">
        <property type="entry name" value="IMPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01964">
        <property type="entry name" value="IMPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005990">
        <property type="entry name" value="IMP_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015875">
        <property type="entry name" value="IMP_DH/GMP_Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001093">
        <property type="entry name" value="IMP_DH_GMPRt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11911">
        <property type="entry name" value="PTHR11911"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00478">
        <property type="entry name" value="IMPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000130">
        <property type="entry name" value="IMPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="SSF54631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01302">
        <property type="entry name" value="IMP_dehydrog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00487">
        <property type="entry name" value="IMP_DH_GMP_RED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 12" id="KW-0129">CBS domain</keyword>
    <keyword evidence="3 7 14" id="KW-0332">GMP biosynthesis</keyword>
    <keyword evidence="2 7 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 10 14" id="KW-0520">NAD</keyword>
    <keyword evidence="5 7 13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4 7 11" id="KW-0630">Potassium</keyword>
    <keyword evidence="7 14" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CBS" evidence="15">
        <location>
            <begin position="101"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="15">
        <location>
            <begin position="161"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="region of interest" description="IMP binding" evidence="7 9">
        <location>
            <begin position="344"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="region of interest" description="IMP binding" evidence="7 9">
        <location>
            <begin position="367"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="region of interest" description="IMP binding" evidence="7 9">
        <location>
            <begin position="391"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="active site" description="Thioimidate intermediate" evidence="7 8">
        <location>
            <position position="311"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="7 8">
        <location>
            <position position="413"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="255"/>
            <end position="257"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="255"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7 10">
        <location>
            <begin position="304"/>
            <end position="306"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7 11">
        <location>
            <position position="306"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7 11">
        <location>
            <position position="308"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7 9">
        <location>
            <position position="309"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7 11">
        <location>
            <position position="311"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7 9">
        <location>
            <position position="428"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="482"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
            <note>ligand shared between two tetrameric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="483"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
            <note>ligand shared between two tetrameric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="484"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
            <note>ligand shared between two tetrameric partners</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000130-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000130-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000130-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR000130-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU003927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU003928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="PJN10006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="501" mass="52537" checksum="4BC72B95C932E0E4" modified="2018-04-25" version="1">MTANVDGVPEKFATLGLTYDDVLLLPGASEVLPNAVDTSSRISRNVRVNIPLLSAAMDKVTESRMAIAMARQGGVGVLHRNLSIEDQVNQVDLVKRSESGMVTDPITVHPDATLAEADALCAKFRISGVPVTDPAGKLLGIVTNRDMAFESDRSRQVREVMTPMPLVTGKVGISGVDAMELLRRHKIEKLPLVDDAGVLKGLITVKDFVKAEQYPNAAKDAEGRLLVGAAVGASPEALERAQALAEAGADFLIVDTSHGHNSNALNWMAKIKSSVGVDVIGGNVATRDGAQALIDAGVDGVKVGVGPGSICTTRVVAGIGVPQVTAIYEAALAARAAGVPVIGDGGLQYSGDIGKALAAGADTVMLGSLLAGCEESPGELMFINGKQFKSYRGMGSLGAMQSRGQGRSYSKDRYFQAEVASDDKLVPEGIEGQVPYRGPLANVLHQLVGGLRQTMGYVGAASIDEMETKGRFVRITSAGLKESHPHDIQMTVEAPNYSRSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JT98</accession>
    <name>A0A2M9JT98_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CG723_20340</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000006">
        <property type="protein sequence ID" value="PJN10068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN10068">
        <property type="protein sequence ID" value="PJN10068"/>
        <property type="gene ID" value="CG723_20340"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PJN10068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="296" mass="32380" checksum="9D6C363F47623AE4" modified="2018-04-25" version="1">MTRKTMHLILGNDCAVTVHEPPLPLTPRFSLSGEYVTVSPHTDQPTHETLLSETFGSVDWLWSGDDEFRFAAADRGLRGVILTVPETLATDAESDRMRSWGRAPRVPGNVRAVDSRHFDARPTRVRWVSETGDQVVCAYESGAGGASQDVLRLRSAPCFDLVFVDRALSGWILDRPADFLVQEWEYAPSRPAPDGVADVLRDCLGTFGEATIGRMQDGEAAAPEVLRSLRARAPTCRRTPVATCCATSWAGSWRAGVTRLPAESRRAGRPSAAVPARPRFDLRHPRGTLYGSIGQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JTZ7</accession>
    <name>A0A2M9JTZ7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CG723_18100</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CB01635</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000005">
        <property type="protein sequence ID" value="PJN10298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN10298">
        <property type="protein sequence ID" value="PJN10298"/>
        <property type="gene ID" value="CG723_18100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="36"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="104"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="141"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="193"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="245"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="301"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="104"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PJN10298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="331" mass="36804" checksum="C2EDE4C1E0F645D0" modified="2018-04-25" version="1">MTTIVNSPKGDPAVREDTPGATRKPRRPGRIRRLGLPYLLLLPALLLEILVHLLPIAIGFFMAFKELTQFYLRDWGAAPWAGLGNFDVAVDFNAPVGKALLHSFWITCVFTLMSVGLCWLLGTAAAVFMQETFTGRGFLRTLFLVPYALPVYAAVITWAFMFQRDNGLVNHVLHDQLGLTGGHPFWLIGDNSFFALLTVSVWKGWPFAFLIVMAGLQNIPKELYEAAAMDGAGIWQQIRRITIPSLRPVNQVLVLVLFLWTFNDFNTPFVLFGRAAPEAADLISVHIYQSSFATWNFGTGAAMSVLLLLFLLLVTGIYLVLTSRGRKVSRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JUU1</accession>
    <name>A0A2M9JUU1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_15085</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000004">
        <property type="protein sequence ID" value="PJN10547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN10547">
        <property type="protein sequence ID" value="PJN10547"/>
        <property type="gene ID" value="CG723_15085"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021400">
        <property type="entry name" value="DUF3039"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11238">
        <property type="entry name" value="DUF3039"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN10547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="95" mass="10250" checksum="349C6F58843E287C" modified="2018-04-25" version="1">MSTLEPERGTGTGTLVEPTPQTSHGDGDHERYAHYVQKDKIMASALEGTPVVALCGKVWVPGRDPKKYPVCPMCKEIYESMGAGGDKDKGGKDKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JUX0</accession>
    <name>A0A2M9JUX0_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NHase_beta domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_15265</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000004">
        <property type="protein sequence ID" value="PJN10577.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN10577">
        <property type="protein sequence ID" value="PJN10577"/>
        <property type="gene ID" value="CG723_15265"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018822">
        <property type="term" value="F:nitrile hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042262">
        <property type="entry name" value="CN_hydtase_beta_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024690">
        <property type="entry name" value="CN_hydtase_beta_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008990">
        <property type="entry name" value="Elect_transpt_acc-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02211">
        <property type="entry name" value="NHase_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50090">
        <property type="entry name" value="SSF50090"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NHase_beta" evidence="1">
        <location>
            <begin position="1"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN10577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="94" mass="10637" checksum="953C648AAD5D2B78" modified="2018-04-25" version="1">MARINDVGGMTGFGAIDTSDDAEPFHADWEARVFALQRALLVKGVFNLDEFRDAIETMPPGEYLAASYYERWFHAIRTLLERKGVIEEGALRDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JV49</accession>
    <name>A0A2M9JV49_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ABC transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CG723_16410</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000004">
        <property type="protein sequence ID" value="PJN10765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN10765">
        <property type="protein sequence ID" value="PJN10765"/>
        <property type="gene ID" value="CG723_16410"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042953">
        <property type="term" value="P:lipoprotein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03255">
        <property type="entry name" value="ABC_MJ0796_LolCDE_FtsE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015854">
        <property type="entry name" value="ABC_transpr_LolD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017911">
        <property type="entry name" value="MacB_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007159">
        <property type="entry name" value="SpoVT-AbrB_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24220:SF654">
        <property type="entry name" value="PTHR24220:SF654"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51740">
        <property type="entry name" value="SPOVT_ABRB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="33"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="domain" description="SpoVT-AbrB" evidence="6">
        <location>
            <begin position="272"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="66"/>
            <end position="73"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51740"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PJN10765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="318" mass="34667" checksum="DF1CC972E8A46058" modified="2018-04-25" version="1">MTTTDPTLADLERRAADRRDQPAYGHDALITCDRLVRIFSTDGVEVQALQGLDLLVREGELMALVGASGSGKSTLMNILAGLDEPTAGAAKVAGCDLLTMGAKERLRYRRDIVGFVWQQTARNLLPYLTAAQNVALPMQLRGGTKRSHKSRRAVELLDLLGVGDCRDRRPQALSGGQQQRVAIAVALANEPSVLLADEPTGELDSHTGEQIFAAFRTANEELGTTIVIVTHDQTVASEVRRTVAIRDGRTSTEVLRRTEVDAATGQESLISREYAMLDRAGRLQLPADHTRALGMRDRVLLELEEDHIGVWPDDTEPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JV87</accession>
    <name>A0A2M9JV87_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 7">4-alpha-glucanotransferase</fullName>
            <ecNumber evidence="3 7">2.4.1.25</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5 7">Amylomaltase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6 7">Disproportionating enzyme</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">malQ</name>
        <name evidence="9" type="ORF">CG723_16560</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CB01635</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>Transfers a segment of a (1-&gt;4)-alpha-D-glucan to a new position in an acceptor, which may be glucose or a (1-&gt;4)-alpha-D-glucan.</text>
            <dbReference type="EC" id="2.4.1.25"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the disproportionating enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.25" evidence="3 7"/>
    <dbReference type="EMBL" id="NNBL01000004">
        <property type="protein sequence ID" value="PJN10790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN10790">
        <property type="protein sequence ID" value="PJN10790"/>
        <property type="gene ID" value="CG723_16560"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004134">
        <property type="term" value="F:4-alpha-glucanotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102500">
        <property type="term" value="F:beta-maltose 4-alpha-glucanotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003385">
        <property type="entry name" value="Glyco_hydro_77"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32438">
        <property type="entry name" value="PTHR32438"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02446">
        <property type="entry name" value="Glyco_hydro_77"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00217">
        <property type="entry name" value="malQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="7" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 9" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="191"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00020295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00031423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00031501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU361207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PJN10790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="699" mass="75616" checksum="4A09FD81BD8B5945" modified="2018-04-25" version="1">MTLARLAALHGIAPSYSPSPGRTVEAPDAALVAVLAALGVDARTPESVRDALVAREAETAAWLLPPTVVLWAGEPAPAWARELPEGVTLELATEQGERVDDWRPPGPVPLGVHRLRATAPDGATADAHLIVAPPRVRTPGERMYGLLVQLYSLLSAKSWGMGDLGDLADLASWAGRTAGAGFVQVNPLHAAVPRGEGPTDPSPYRPSSRRFPDPVHLRVEDIPEYAYLPDADRDRVRELLAEAARLRDGVLHKGALIDRDAVWDLKRRALDLVVRVPLSPGRRAAYWDFLAEQGADLDHHATWCALAERHGPDWHTWPEPLRDPGSGETADARTELMDRVDFHSHLAWLTDTQLATAQRSARDAGMPVGLVHDLAVGVHPEGADAWAQQHIFAAGMSIGAPPDAFNSRGQDWGLPPWRPDRLAAAGYAPYRALLRGLFAHAGAVRIDHVMGLFRLWWVPAGQPPTEGAYVRYDAEAMLAVLALEAGRADALVIGEDLGTVEPGVREALHARGVLGTSVLWFERDWDGTGRPVPPERWRTDCVATATTHDLPSTAARLTGDHVRLRDSLGLLGRPLAREQAEATAEVAEWTALFARLGLLPGGGGQGLSEEEEIRAVHRFLLLTPARMVGVWLPDAVGDRRPQNLPGTSDEYPNWRLPVADATGRPVTFEELTASPRAHALIEVLRSGLPRTAPPGARPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JVL1</accession>
    <name>A0A2M9JVL1_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Heme chaperone HemW</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CG723_17045</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CB01635</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Probably acts as a heme chaperone, transferring heme to an unknown acceptor. Binds one molecule of heme per monomer, possibly covalently. Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the anaerobic coproporphyrinogen-III oxidase family. HemW subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000004">
        <property type="protein sequence ID" value="PJN10872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN10872">
        <property type="protein sequence ID" value="PJN10872"/>
        <property type="gene ID" value="CG723_17045"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004109">
        <property type="term" value="F:coproporphyrinogen oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006779">
        <property type="term" value="P:porphyrin-containing compound biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.30.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034505">
        <property type="entry name" value="Coproporphyrinogen-III_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaB/NifB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004559">
        <property type="entry name" value="HemW-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023404">
        <property type="entry name" value="rSAM_horseshoe"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13932">
        <property type="entry name" value="PTHR13932"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00562">
        <property type="entry name" value="HemN-like__clustered_with_heat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00539">
        <property type="entry name" value="hemN_rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="2" id="KW-0143">Chaperone</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2" id="KW-0349">Heme</keyword>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="domain" description="Radical SAM core" evidence="3">
        <location>
            <begin position="24"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU364116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PJN10872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="410" mass="44017" checksum="EC2433639312EC2B" modified="2018-04-25" version="1">MPSALPDGEPVPDDGALPASALAGAAERPLGFYLHVPYCATRCGYCDFNTYTATELRGSGGVLASRDNYADTLVDEVRLARKVLGDAPRQVRTVFVGGGTPTLLAADDLVRMLGAIRDEFGLAPDAEVTTEANPESVGPAYLETLREGGFNRISFGMQSAKQHVLKILDRTHTPGRPEACVAEARAAGFDHVNLDLIYGTPGESDDDWRASLEAAIGAGPDHVSAYALIVEEGTQLARRIRRGEVPMTDDDVHADRYLIADEVLGGAGFDWYEVSNWATTDAGRCLHNELYWRGADWWGAGPGAHSHVGGVRWWNVKHPGAYAGRLAEGRSPGAGRELLSDEDRRVERILLELRLLEGCPLSLLKPAGRAAAGRALSDGLLEAAPYESGRAVLTLRGRLLADAVVRDLVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JVX9</accession>
    <name>A0A2M9JVX9_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Histidine kinase</fullName>
            <ecNumber evidence="4">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CG723_08275</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CB01635</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="4"/>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN10992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN10992">
        <property type="protein sequence ID" value="PJN10992"/>
        <property type="gene ID" value="CG723_08275"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038318">
        <property type="entry name" value="KdpD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025201">
        <property type="entry name" value="KdpD_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003852">
        <property type="entry name" value="Sig_transdc_His_kinase_KdpD_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13493">
        <property type="entry name" value="DUF4118"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02702">
        <property type="entry name" value="KdpD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="380"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="412"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="459"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="9">
        <location>
            <begin position="622"/>
            <end position="833"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PJN10992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="848" mass="90398" checksum="EC0B8D0522809C1D" modified="2018-04-25" version="1">MARGKLRIYLGAAPGVGKTYAMLSEAHRRVERGTDCVVGFVEHHDRPRTEVMLHGLEQVVRKELQYRGSVFTEMDVDAVLARRPQVALVDELAHTNIPGSRNAKRWQDVEELLAAGIDVISTVNIQHLESLGDVVESITGIRQRETVPDEVVRRADQIELVDMSPPALRRRMAHGNIYKPDKVDAALSNYFRPGNLTALRELALLWVADRVDAYLTEYRSEHRVSKIWGSRERIVVGLTGGPEGRTLIRRAARLAEKGAGGEVMAVYIARSDGLTSASPKELVVQRTLVEDLGGTFHHVIGDDIPTALLDFARGVNATQIALGVSRRKGWQYVFGPGVGATVARDSGPDLDVHLITHDEAGKGRGLPVARTARLGRSRVVLGWLAGVAGPALLTLLLTGVAPEVGLANDMLLFLALTVAAALLGGLYPALASALVGSLLLNWFFTPPVHTLTIADPKNVVAIAIFVGVAVSVASVVDLAARRTHQAARLRAESEILSFLAGSVLRGETSLEALLERVRETFGMESVALLERAGDVEPWTCAGSVGTGAVVGRPEDADADMPVGDRMALALSGRVLPAEDRRVLAAFAAQAAVVLDRQRLQSEADQSRSLAEGNRIRTALLAAVSHDLRTPLAGIKAAVSSLRSDDVAWSEEDHAELLEGIEDGADRLDNLVGNLLDMSRLQTGTVTPLIREIDLDEVVPMALGGVPEGSVELEIPETLPMVTVDPGLLERSVANLVENAVKYSPSGERVLVSASAIADRVEVRVVDRGPGVPDEAKDRIFEPFQRYGDAPGGAGVGLGLAVARGFAEAMGGTLSAEDTPGGGLTMVLTLPTASGLEPARPDLPETATS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JW48</accession>
    <name>A0A2M9JW48_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_08685</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN11048.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN11048">
        <property type="protein sequence ID" value="PJN11048"/>
        <property type="gene ID" value="CG723_08685"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014696118" evidence="1">
        <location>
            <begin position="29"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN11048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="101" mass="11687" checksum="CD6246B7D954A6E3" modified="2018-04-25" version="1">MRKLARATATAALTVAAIAIPLTGTAMASTATAAPAQTHRLLHKAALHNNGWCGDYRYNRHHRGHYWSRWDDNCGYRKDWRGHRHVNYRGYDDYRNCDRDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-06-02" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JWE1</accession>
    <name>A0A2M9JWE1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ArsR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CG723_09615</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN11194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN11194">
        <property type="protein sequence ID" value="PJN11194"/>
        <property type="gene ID" value="CG723_09615"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014757">
        <property type="entry name" value="Tscrpt_reg_IclR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005471">
        <property type="entry name" value="Tscrpt_reg_IclR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09339">
        <property type="entry name" value="HTH_IclR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01614">
        <property type="entry name" value="IclR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00346">
        <property type="entry name" value="HTH_ICLR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51077">
        <property type="entry name" value="HTH_ICLR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51078">
        <property type="entry name" value="ICLR_ED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH iclR-type" evidence="4">
        <location>
            <begin position="47"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="domain" description="IclR-ED" evidence="5">
        <location>
            <begin position="109"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="10"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PJN11194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="288" mass="30388" checksum="C4410740CC834184" modified="2018-04-25" version="1">MDREESLKSTDAPTNASSATRRPTPSELRPQEPHGSTQGQSETSGPVNSVAKALRVLHALAHPDAPHKLGEIAERSGVPKASTHRILATLIEEGYAVPDGEGRYGIGTQLRALAAQVLSDDTVGIDAVLRALQQRLGQAVHLAVLSGDHATYTHKVDPGLAYRIATEVGTRLPLHASAAGKVLLAHLPERETKALLDRAGLPARTSHTVTDRTTLLSQLETVRHTGFATDYEEADEAICSLAAPVLDTDGSPVGAVSVSSLAALVTEDQLTAFAPAVRQAAQEVSRRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JWH2</accession>
    <name>A0A2M9JWH2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Precorrin-8X methylmutase</fullName>
            <ecNumber evidence="6">5.4.99.61</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">cobH</name>
        <name evidence="6" type="ORF">CG723_09845</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CB01635</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; adenosylcobalamin biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CobH/CbiC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.4.99.61" evidence="6"/>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN11233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN11233">
        <property type="protein sequence ID" value="PJN11233"/>
        <property type="gene ID" value="CG723_09845"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00148"/>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016993">
        <property type="term" value="F:precorrin-8X methylmutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009236">
        <property type="term" value="P:cobalamin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003722">
        <property type="entry name" value="Cbl_synth_CobH/CbiC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036588">
        <property type="entry name" value="CobH/CbiC_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02570">
        <property type="entry name" value="CbiC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63965">
        <property type="entry name" value="SSF63965"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0169">Cobalamin biosynthesis</keyword>
    <keyword evidence="4 6" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CbiC" evidence="5">
        <location>
            <begin position="13"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02570"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PJN11233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="213" mass="21942" checksum="4EE1862FE51A6377" modified="2018-04-25" version="1">MSTAFEYEKSGAEIYRRSFATIRAEADLGGLPAEVAQVAVRMIHACGMVDLAGDLAYSPDVAVRAREALRGGAPVLCDVSMVASGITRKRLPADNDVVCTLSDPSVPALAERLGTTRSAAALELWRERMGGAVVAVGNAPTALFRLLELVREGAAPPAAVIGVPVGFVGAVESKDALVEHAGELGLEYLVVRGRRGGSAMAAAAVNAVACAVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JWN6</accession>
    <name>A0A2M9JWN6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CG723_10310</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN11316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN11316">
        <property type="protein sequence ID" value="PJN11316"/>
        <property type="gene ID" value="CG723_10310"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PJN11316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="172" mass="19161" checksum="AAC70C33B4E18FB3" modified="2018-04-25" version="1">MLHGSKEGTSDAGGGELMVPMAWLYAEYIADELLRTGDLMPPTSFEFRAGRDALALTIFLSDTDGELSGIRVVSQLETWLSLTAYDQPWQYWVREHMGRLAAQALDENRPSPDLELAEAAWRWLEETELLAPDLDSVPGRGSLPDEEDDGPKVWTPAWQLGLPLGHLAIHLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-05-25" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JWR7</accession>
    <name>A0A2M9JWR7_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Glutamate--cysteine ligase EgtA</fullName>
            <ecNumber evidence="2">6.3.2.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Gamma-glutamylcysteine synthase</fullName>
            <shortName evidence="2">GCS</shortName>
            <shortName evidence="2">Gamma-ECS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2 4" type="primary">egtA</name>
        <name evidence="4" type="ORF">CG723_10445</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CB01635</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the synthesis of gamma-glutamylcysteine (gamma-GC). This compound is used as substrate for the biosynthesis of the low-molecular thiol compound ergothioneine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 2 3">
            <text>ATP + L-cysteine + L-glutamate = ADP + gamma-L-glutamyl-L-cysteine + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:13285"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:35235"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58173"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.2.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; ergothioneine biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 3">Belongs to the glutamate--cysteine ligase type 2 family. EgtA subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.2" evidence="2"/>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN11340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN11340">
        <property type="protein sequence ID" value="PJN11340"/>
        <property type="gene ID" value="CG723_10445"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA01014"/>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004357">
        <property type="term" value="F:glutamate-cysteine ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052699">
        <property type="term" value="P:ergothioneine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006750">
        <property type="term" value="P:glutathione biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02034">
        <property type="entry name" value="EgtA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017809">
        <property type="entry name" value="EgtA_Actinobacteria"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035434">
        <property type="entry name" value="GCL_bact_plant"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006336">
        <property type="entry name" value="GCS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014746">
        <property type="entry name" value="Gln_synth/guanido_kin_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011556">
        <property type="entry name" value="Glut_cys_lig_pln_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34378">
        <property type="entry name" value="PTHR34378"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34378:SF1">
        <property type="entry name" value="PTHR34378:SF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04107">
        <property type="entry name" value="GCS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017901">
        <property type="entry name" value="GCL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55931">
        <property type="entry name" value="SSF55931"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03444">
        <property type="entry name" value="EgtA_Cys_ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 3 4" id="KW-0436">Ligase</keyword>
    <keyword evidence="2 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00029283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR017901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PJN11340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="430" mass="46287" checksum="D385B4CD4DF1AC14" modified="2018-04-25" version="1">MPEGDCTELGTAALVTEAEVEALVRGICFKTGPPRTVGVEVEWLVHEPRRPRLPLAPERLDAAYAALGALPLSSALTVEPGGQLELSSLPASSLMDCVSAVSADLTAVRTSLAARGLALTGLGTDPWRPPRRLLHEPRYDAMESWFDRTGPAGRAMMCSSASVQVCLDAGYEEPGPLGHGRRWRLSHLLGAVLVSAFANSPMLCGRPTGWRSTRQAVWEEIDPGRSGAPPLDVEPREAWVRHVLDAPVMCVRKDSGPWDVPDGMSLRTWLRTGGPRPATRGDVEYHLSTLFPPVRPRGHLELRMIDAQPGDDGWIVPLAVTTALFDDPEAAETAYRTVKPLSERAGPLPAPHNRLWRDAARHGPSDPELAEAAVTCFAAALDALPRLGASPRVLAAVSAFMDRYVVRGRCPADDVLDHIDAPAPGRTVTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JWT3</accession>
    <name>A0A2M9JWT3_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Glucose-1-phosphate adenylyltransferase</fullName>
            <ecNumber evidence="9">2.7.7.27</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">ADP-glucose pyrophosphorylase</fullName>
            <shortName evidence="9">ADPGlc PPase</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">ADP-glucose synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9 12" type="primary">glgC</name>
        <name evidence="12" type="ORF">CG723_10130</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">CB01635</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Involved in the biosynthesis of ADP-glucose, a building block required for the elongation reactions to produce glycogen. Catalyzes the reaction between ATP and alpha-D-glucose 1-phosphate (G1P) to produce pyrophosphate and ADP-Glc.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>alpha-D-glucose 1-phosphate + ATP + H(+) = ADP-alpha-D-glucose + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:12120"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57498"/>
            <dbReference type="ChEBI" id="CHEBI:58601"/>
            <dbReference type="EC" id="2.7.7.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="9 10">Glycan biosynthesis; glycogen biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the bacterial/plant glucose-1-phosphate adenylyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.27" evidence="9"/>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN11282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN11282">
        <property type="protein sequence ID" value="PJN11282"/>
        <property type="gene ID" value="CG723_10130"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00164"/>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008878">
        <property type="term" value="F:glucose-1-phosphate adenylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005978">
        <property type="term" value="P:glycogen biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00624">
        <property type="entry name" value="GlgC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011831">
        <property type="entry name" value="ADP-Glc_PPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005836">
        <property type="entry name" value="ADP_Glu_pyroP_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023049">
        <property type="entry name" value="GlgC_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005835">
        <property type="entry name" value="NTP_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43523">
        <property type="entry name" value="PTHR43523"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00483">
        <property type="entry name" value="NTP_transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="SSF51161"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02091">
        <property type="entry name" value="glgC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00808">
        <property type="entry name" value="ADP_GLC_PYROPHOSPH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00809">
        <property type="entry name" value="ADP_GLC_PYROPHOSPH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00810">
        <property type="entry name" value="ADP_GLC_PYROPHOSPH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 9" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="7 9 10" id="KW-0320">Glycogen biosynthesis</keyword>
    <keyword evidence="2 9" id="KW-0321">Glycogen metabolism</keyword>
    <keyword evidence="5 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4 9 12" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9 12" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="NTP_transferase" evidence="11">
        <location>
            <begin position="9"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="region of interest" description="Alpha-D-glucose 1-phosphate binding" evidence="9">
        <location>
            <begin position="180"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="99"/>
        </location>
        <ligand>
            <name>alpha-D-glucose 1-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58601"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="164"/>
        </location>
        <ligand>
            <name>alpha-D-glucose 1-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58601"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="198"/>
        </location>
        <ligand>
            <name>alpha-D-glucose 1-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58601"/>
        </ligand>
    </feature>
    <feature type="site" description="Could play a key role in the communication between the regulatory and the substrate sites" evidence="9">
        <location>
            <position position="61"/>
        </location>
    </feature>
    <feature type="site" description="Could play a key role in the communication between the regulatory and the substrate sites" evidence="9">
        <location>
            <position position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PJN11282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="406" mass="43615" checksum="B1318747DFFB1EB3" modified="2018-04-25" version="1">MRGGPSVLGIVLAGGEGKRLLPLTADRAKPAVTFGGTYRLVDFVLSNLVNADILRICVLTQYKSHSLDRHVTTTWRMSSLLGNYVTPVPAQQRLGPRWYLGSADAILQSLNLVHDEQPDYIAVFGADHVYRMDPRQMLQQHIESGAGVTVAGIRVPRADASAFGIITPAGDGTRVDRFLEKPADPPGIPGSPHQVFASMGNYVFTTKTLIDALQQDSEMPNSVHDMGGSILPMLTERGVAQLYDFDGNHVPGETPHEHGYWRDVGTLDAYYEAHLDLLSDKPAFNLDNRRWPIYTHPGQLPPAKFCAGGIAGQSIVSPGCVIRGQVTRSVLSPGVTVEEGAVVQGSVLHDNVRIGRGAVVRGAVLDKNVDVPPGATIGVNPERDAELYTVSKGGVIALGKGRQVVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JWY9</accession>
    <name>A0A2M9JWY9_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Gamma-glutamyl-hercynylcysteine sulfoxide hydrolase</fullName>
            <ecNumber evidence="1">3.5.1.118</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Gamma-glutamyl hercynylcysteine S-oxide hydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1 3" type="primary">egtC</name>
        <name evidence="3" type="ORF">CG723_10435</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the hydrolysis of the gamma-glutamyl amide bond of hercynyl-gamma-L-glutamyl-L-cysteine sulfoxide to produce hercynylcysteine sulfoxide, a step in the biosynthesis pathway of ergothioneine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>gamma-L-glutamyl-hercynylcysteine S-oxide + H2O = L-glutamate + S-(hercyn-2-yl)-L-cysteine S-oxide</text>
            <dbReference type="Rhea" id="RHEA:42684"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:82703"/>
            <dbReference type="ChEBI" id="CHEBI:82706"/>
            <dbReference type="EC" id="3.5.1.118"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; ergothioneine biosynthesis.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.118" evidence="1"/>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN11338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN11338">
        <property type="protein sequence ID" value="PJN11338"/>
        <property type="gene ID" value="CG723_10435"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA01014"/>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016811">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052699">
        <property type="term" value="P:ergothioneine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02036">
        <property type="entry name" value="EgtC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017808">
        <property type="entry name" value="EgtC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026869">
        <property type="entry name" value="EgtC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032889">
        <property type="entry name" value="EgtC_Actinobacteria"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017932">
        <property type="entry name" value="GATase_2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13230">
        <property type="entry name" value="GATase_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="SSF56235"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03442">
        <property type="entry name" value="TIGR03442"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51278">
        <property type="entry name" value="GATASE_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutamine amidotransferase type-2" evidence="2">
        <location>
            <begin position="2"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN11338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="251" mass="26865" checksum="B5916D4835182F0E" modified="2018-04-25" version="1">MCRQLAYLGPAAPLGDVLVTPSHSLLRQSWEPRRQRHGTVNADGFGVGWYADGDPVPARYRRAGPIWGDQSFADLARVVRSGAVLAAVRDATLGGADGEAAAAPFASGPWLFSHNGAVRGWPRSLAPLTTAVPPVDLLSLEARCDSAFVWALLLHRLRSGDDQGQALADTVLEVAEAAPGSRLNLLLTDGETITATAWGDSLWYLTEPGRSTVVASEPYDDDPHWREVPDRTLLAASRTDVLLTPLKEPSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JXB8</accession>
    <name>A0A2M9JXB8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_11580</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN11535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN11535">
        <property type="protein sequence ID" value="PJN11535"/>
        <property type="gene ID" value="CG723_11580"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014598679" evidence="1">
        <location>
            <begin position="31"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN11535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="133" mass="13887" checksum="E856B1081BAE9267" modified="2018-04-25" version="1">MKTRNTVIRALATGACAIGLVAGLQGQAWAGTVTIYAPSGAGNATWNADPDGSIPGDAIRACDTKSDGWGIETALDYNYDGIMDRRVDTRGHTAGYCSSWKGGDLTEGRTVRMYVTPVSGSSYGPSTYIDVTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JXK0</accession>
    <name>A0A2M9JXK0_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PS_pyruv_trans domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_11325</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN11487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN11487">
        <property type="protein sequence ID" value="PJN11487"/>
        <property type="gene ID" value="CG723_11325"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007345">
        <property type="entry name" value="Polysacch_pyruvyl_Trfase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04230">
        <property type="entry name" value="PS_pyruv_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PS_pyruv_trans" evidence="1">
        <location>
            <begin position="21"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN11487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="414" mass="44339" checksum="B4F8A7CCCBD100D6" modified="2018-04-25" version="1">MTSADETPVRVGIFGLLGSGNLGNDGSLEAVLGYLRAERPEAVVDALCGGPEAVTTRFGIPATRLHWYRGEYRTASRAGAIVAKGLGKLVDAVRTAAWVRRHDVVIVPGMGVLEATLPLRPWGFPYALFLLCASGRLCGTRVALVGVGAAPIGNRPIRALVRWSARLATYRSYRDAQSRDAMREMGVDTAQDEVYPDLTFALPALPASAPSDPPGPVCVGVMDFHGSDDDRARAEEIHRRYLDGTTRFVRALAEDGRPVRLLTGDECDAPVVAAILDAVDSPLVTAAEAASLADLMKEMAAADTVVATRYHNLVCALKVGVPTLALSYAAKSDALMDRMGLADFRHPAREVDADQLRAQFRALEQRSAELRRTLTERNLTAAQQLEDQFTALTTALFPAAGPAPALANALRETP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JXS9</accession>
    <name>A0A2M9JXS9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Beta-ketoacyl-ACP reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CG723_12265</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN11648.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN11648">
        <property type="protein sequence ID" value="PJN11648"/>
        <property type="gene ID" value="CG723_12265"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PJN11648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="255" mass="26568" checksum="07FFEF36923F4C0F" modified="2018-04-25" version="1">MSANSSAQKVAVVTGAARGIGAATAARLARDGFAVAVFDLDEAACARTVEEIEKEGGRALAVSCDVSDPEQVEAGVARVAAELGAPAVLVNNAGIIRDNLIFRMTPQDFDSVIGVHLRGAFLMAKACQAHMVDAKWGRIVNMSSAAALGNRGQSNYSSAKAGLQALTKTLAIELGPFGVTANCVAPGFIATEMTEATAQRMGITFEEFTERYAKTIPVRRGGRPEDIAQAVSFFVREEAGFVSGQILYVAGGPKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-06-02" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JXZ1</accession>
    <name>A0A2M9JXZ1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_12715</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN11718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN11718">
        <property type="protein sequence ID" value="PJN11718"/>
        <property type="gene ID" value="CG723_12715"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="162"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="164"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN11718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="191" mass="20960" checksum="FC653F01D0B73FE9" modified="2018-04-25" version="1">MAYGGECAGTGPFFRLAWRGSHYPDRPVEDLWITLDRDVDGGWWFDGYFLGRLPLGQGAPRSAEFARWLLEAPPTGPYEREFTLIDREPQAGSARIAAGTLLTVGFLLGREEPGGPEYLQLLPSGETAVRHLGFEVCAPLECEPLPRVALEVAAAGLLDAATDQGSRMRDRRGLVRRARDRGPRRAGGTPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JYB1</accession>
    <name>A0A2M9JYB1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">2-hydroxycyclohexanecarboxyl-CoA dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CG723_13010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN11767.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN11767">
        <property type="protein sequence ID" value="PJN11767"/>
        <property type="gene ID" value="CG723_13010"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PJN11767.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="259" mass="26403" checksum="87CB033B70269DCE" modified="2018-04-25" version="1">MLTDALKDKVAVIYGGAGSLGAGVARAYTDAGARVFLAGRTEDTLRKASAEVGAEYDVVDALDEAAVEAQADAVVERAGRIDISFNLVPRGDLQGIPLTEMSVDDYTRPVVQGISSQFITARAAARRMVNQGGGVILSLDSGSKNGTPMLGGTGAADGAMDALIRQLAQELGPSGVRALGIWTAGVADTLTPEKLAGAGAPGMDEAALQGVLAHLDSLRMTKRSPRIADIAALATFLASDAASSITGTWINATAGMFPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JZ40</accession>
    <name>A0A2M9JZ40_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Molybdopterin molybdenumtransferase</fullName>
            <ecNumber evidence="7">2.10.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CG723_10895</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CB01635</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 7">Catalyzes the insertion of molybdate into adenylated molybdopterin with the concomitant release of AMP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>adenylyl-molybdopterin + H(+) + molybdate = AMP + H2O + Mo-molybdopterin</text>
            <dbReference type="Rhea" id="RHEA:35047"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:36264"/>
            <dbReference type="ChEBI" id="CHEBI:62727"/>
            <dbReference type="ChEBI" id="CHEBI:71302"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.10.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 7">Cofactor biosynthesis; molybdopterin biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 7">Belongs to the MoeA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.10.1.1" evidence="7"/>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN12145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN12145">
        <property type="protein sequence ID" value="PJN12145"/>
        <property type="gene ID" value="CG723_10895"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00344"/>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061599">
        <property type="term" value="F:molybdopterin molybdotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006777">
        <property type="term" value="P:Mo-molybdopterin cofactor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032324">
        <property type="term" value="P:molybdopterin cofactor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00887">
        <property type="entry name" value="MoeA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.340.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.980.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036425">
        <property type="entry name" value="MoaB/Mog-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001453">
        <property type="entry name" value="MoaB/Mog_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038987">
        <property type="entry name" value="MoeA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005111">
        <property type="entry name" value="MoeA_C_domain_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036688">
        <property type="entry name" value="MoeA_C_domain_IV_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005110">
        <property type="entry name" value="MoeA_linker/N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036135">
        <property type="entry name" value="MoeA_linker/N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10192">
        <property type="entry name" value="PTHR10192"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00994">
        <property type="entry name" value="MoCF_biosynth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03454">
        <property type="entry name" value="MoeA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03453">
        <property type="entry name" value="MoeA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00852">
        <property type="entry name" value="MoCF_biosynth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53218">
        <property type="entry name" value="SSF53218"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63867">
        <property type="entry name" value="SSF63867"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63882">
        <property type="entry name" value="SSF63882"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 7" id="KW-0500">Molybdenum</keyword>
    <keyword evidence="6 7" id="KW-0501">Molybdenum cofactor biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="MoCF_biosynth" evidence="9">
        <location>
            <begin position="176"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="109"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU365090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PJN12145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="396" mass="41050" checksum="FEF17019041EE158" modified="2018-04-25" version="1">MVWEQARRIARDCVGQPLPVVPRSLADALGHTLAEPLTALTDLPPFDTSAMDGWAVAGPGPWLVGGAAVLAGDRSAPLRDHGTAVPIATGARLPTGATAVLRREHGEFDAESGTLHDRSTGPGAVAPGRDIRPRGQECRAGEALIPAGITVTPAVLGLAAAAGYDRLAVHRRPTVELLVLGDELLEAGLPRHGRVRDALGPMLPPWLRSCGADVIGRRRVADDLGLLREAVHNSPADVVVTTGSTAAGPVDFLHATLEEAGARLLVDSVAVRPGHPMLLAELPPTPDGRTRRLVGLPGNPLAAVAGTVTLAAPLLRHLGGHPDAEPRRMRAATELPGHPRDTRLLPVRRTHHEVAPLPFDGPAMLRGLAFADGLAVVPPGGVPAGATAEVLEVPGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JZM2</accession>
    <name>A0A2M9JZM2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CG723_04270</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000002">
        <property type="protein sequence ID" value="PJN12280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN12280">
        <property type="protein sequence ID" value="PJN12280"/>
        <property type="gene ID" value="CG723_04270"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PJN12280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="88" mass="9324" checksum="313BDCD15A6A307A" modified="2018-04-25" version="1">MDSTPIVVHPPAPTGGRRVAIQGHVAGIVRSDADLVELLCQAGVTVHSALLDDEAWVKWRGGRAHHYASTVNIVDAPRASESPQPPQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JZP0</accession>
    <name>A0A2M9JZP0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_04570</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000002">
        <property type="protein sequence ID" value="PJN12334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN12334">
        <property type="protein sequence ID" value="PJN12334"/>
        <property type="gene ID" value="CG723_04570"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027860">
        <property type="entry name" value="DUF4429"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14472">
        <property type="entry name" value="DUF4429"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4429" evidence="1">
        <location>
            <begin position="15"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4429" evidence="1">
        <location>
            <begin position="142"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN12334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="287" mass="30977" checksum="27335F7B238994AF" modified="2018-04-25" version="1">MSRMGDVLAGFHAAWEFGSDSVLIRFERGIRTPKLLQALGERRIPYEAIAAVTLTPGKRGTVVLRAVPRPGADPLMDAAAGQLKEGCDPYRLVLPAERETLAEYYADELRDVLALDDDAPAGRYLVAAPEAPLHFKAYDGKASFDGKSVAFRWFWTGASSAKWKAGDKSFPVSDLSGVEWRSPEVFEGHLRLLRRDTSEQPAQADQDPAAVIFGLGYGPVHESLPFAASILAAVRAGSAVPASGASPARRDPADIADRIRHLGELHQAGLVTDSEFSTKKAELLAEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JZW9</accession>
    <name>A0A2M9JZW9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_04835</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000002">
        <property type="protein sequence ID" value="PJN12380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN12380">
        <property type="protein sequence ID" value="PJN12380"/>
        <property type="gene ID" value="CG723_04835"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014670482" evidence="2">
        <location>
            <begin position="34"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="183"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="201"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN12380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="502" mass="51873" checksum="2D085BE8CD878962" modified="2018-04-25" version="1">MTVKASHPSRLRRRAAAVAVGAMVAAAAPGAGAAPATQHVDARLDYTCRFPSGEMPVTMTVTAQLPEEARVSEEIRPSDVGTSVELPQAAVDELRTLGAASATPATGLSVGVTQGADTATTTWKGTGQPTPLPATGSLRLDTSGDVAAVSTGTPAELAFDAGELDLGLALSADQGAPANTPFLSVSCTPKSPDSGHLATVRVTDGTGTTTPDPSDTPGTTPSGSPDDDKSRDTGPRVATPRSATPREGSAPPCHKNPDAKLPLVAYITGLSNVDKLKGASLIPLSCTQADQGPQSLKVMPDGVHLIQHSTARLFNDGKEQSTVGTGTFLTFGFMPTEAKMILEQTGEMTLDSDLNATKGMGRTDIRLPLTLRLYDVRVNGTPLDVGPNCRTRGSLYSTDPDPARDTKDHVHLLGTVARQPNGAYAGYTLTTGGPLTTTLTIPPFTGCGVDEDLDALLTASISGPGNFAKQIQGQTCATDVMPRPPAECTEDRQPVVIPVPQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K025</accession>
    <name>A0A2M9K025_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CG723_05510</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CB01635</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000002">
        <property type="protein sequence ID" value="PJN12492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN12492">
        <property type="protein sequence ID" value="PJN12492"/>
        <property type="gene ID" value="CG723_05510"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="34"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="109"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="146"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="239"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="270"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="304"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="109"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PJN12492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="332" mass="37488" checksum="8D402F4D23782103" modified="2018-04-25" version="1">MTVAVDSTAAKTRGGRAPRPGPFGRLRRSYQKHWYAYAMIAPVVVVLGVLVIYPLVRGFYLTLTDADSLNSARTIGVNHIDATYQFIGLDNYADILWGPTSYDRFWSHFIWTIVWTALCVALHYVIGLGLAMLLNQKVRGRTFYRLLLILPWAVPTFVTVFSWRIMLSDSGIINSVLGSLHLPQPQWLEDTFFQRSAAILVNTWCGVPFMMVSLLGGLQSIDPVLYEAAEMDGASPWQRFWNVTLPGLRSVSSTVVLLGVIWTFNQFNVIFLLFGNTAPDAQILVTWAYYLGFGQQPRDYAQSAAYGVLLLSLLAVFTSFYYRWLNRNEQLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K062</accession>
    <name>A0A2M9K062_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 7">Octanoyltransferase</fullName>
            <ecNumber evidence="6 7">2.3.1.181</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Lipoate-protein ligase B</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Lipoyl/octanoyl transferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Octanoyl-[acyl-carrier-protein]-protein N-octanoyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">lipB</name>
        <name evidence="13" type="ORF">CG723_05675</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">CB01635</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5 6 7">Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6 7">
            <text>L-lysyl-[protein] + octanoyl-[ACP] = H(+) + holo-[ACP] + N(6)-octanoyl-L-lysyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:17665"/>
            <dbReference type="Rhea" id="RHEA-COMP:9636"/>
            <dbReference type="Rhea" id="RHEA-COMP:9685"/>
            <dbReference type="Rhea" id="RHEA-COMP:9752"/>
            <dbReference type="Rhea" id="RHEA-COMP:9928"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:64479"/>
            <dbReference type="ChEBI" id="CHEBI:78463"/>
            <dbReference type="ChEBI" id="CHEBI:78809"/>
            <dbReference type="EC" id="2.3.1.181"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 6 7">Protein modification; protein lipoylation via endogenous pathway; protein N(6)-(lipoyl)lysine from octanoyl-[acyl-carrier-protein]: step 1/2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="miscellaneous">
        <text evidence="6">In the reaction, the free carboxyl group of octanoic acid is attached via an amide linkage to the epsilon-amino group of a specific lysine residue of lipoyl domains of lipoate-dependent enzymes.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6 7">Belongs to the LipB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.181" evidence="6 7"/>
    <dbReference type="EMBL" id="NNBL01000002">
        <property type="protein sequence ID" value="PJN12522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN12522">
        <property type="protein sequence ID" value="PJN12522"/>
        <property type="gene ID" value="CG723_05675"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00538">
        <property type="reaction ID" value="UER00592"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033819">
        <property type="term" value="F:lipoyl(octanoyl) transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009249">
        <property type="term" value="P:protein lipoylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16444">
        <property type="entry name" value="LipB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00013">
        <property type="entry name" value="LipB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004143">
        <property type="entry name" value="BPL_LPL_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000544">
        <property type="entry name" value="Octanoyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020605">
        <property type="entry name" value="Octanoyltransferase_CS"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016262">
        <property type="entry name" value="LPLase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51733">
        <property type="entry name" value="BPL_LPL_CATALYTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01313">
        <property type="entry name" value="LIPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6 7" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="13" id="KW-0436">Ligase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="BPL/LPL catalytic" evidence="12">
        <location>
            <begin position="35"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="6 9">
        <location>
            <begin position="73"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="6 9">
        <location>
            <begin position="186"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="6 9">
        <location>
            <begin position="199"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="261"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="262"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-thioester intermediate" evidence="6 8">
        <location>
            <position position="217"/>
        </location>
    </feature>
    <feature type="site" description="Lowers pKa of active site Cys" evidence="6 10">
        <location>
            <position position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00024732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR016262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR016262-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR016262-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR016262-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PJN12522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="283" mass="31148" checksum="6DA589A5D6C68187" modified="2018-04-25" version="1">MNELRFVRLGFGADSVDYQDAWDEQRRVHAARFADEAPDTCLLLEHPPVYTAGRRTAPEERPLDGTPVVDVDRGGKITWHGPGQLVGYPIQKLPRPVDVVAHLRRLEDAMIAVCAEFGVETSRVEGRAGVWVLGDAKDSAERPRLGGLSLDFDPRVNDSEFDPRLNGPEYAPSNAGQRREDRKICAMGIRVAKGVTMHGFALNVNPDTSNFDKIIPCGIRDAGVTSLSYELGREVTIDEVLPVAERHLRDVLENAALAPRVIEKAPEREPDKASAQEPDKATA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K0D0</accession>
    <name>A0A2M9K0D0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Long-chain fatty acid--CoA ligase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_05980</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000002">
        <property type="protein sequence ID" value="PJN12579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN12579">
        <property type="protein sequence ID" value="PJN12579"/>
        <property type="gene ID" value="CG723_05980"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-binding" evidence="1">
        <location>
            <begin position="23"/>
            <end position="466"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN12579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="598" mass="64132" checksum="B802F936421F1BBD" modified="2018-04-25" version="1">MREFSLPALYEVPADGNLTDIVRRNAAQHPDVAVIARKVNGTWQDVTATTFLAEVRSAAKGLIASGVQPGDRVGLMSRTRYEWTLLDFAIWSAGAITVPVYETSSAEQIQWILGDSGAVACVVESVAHAATVESVRDGLPGLTHVWQIDAGGVQELDRAGADVSDVTVDERSAVAKADDPATIVYTSGTTGRPKGCVLTHRSFFAECGNVVERLKPLFRTGECSVLLFLPVAHVFGRLVEVASLMAPIKLGHAPDIKHLTDELAAFRPTLILGVPRVFEKVYNSARAKAQADGKGKIFDKAADTAIEYSRALDTPKGPSIGLKLKYKTFDKLVYSKLRAVLGGRGEYAISGGAPLGERLGHFFRGIGFTVLEGYGLTESCAATAFNPWDRQKIGTVGQPLPGSVVRIADDGEVLLHGEHLFSGYWNNEAATGEALADGWFHTGDIGTLDEDGYLRITGRKKEIIVTAGGKNVAPAVIEDRIRAHALVAECMVVGDGRPFVGALVTVDDEFLGRWAAEHGKPADSTAVSLRDDADLLAAIQTAVDDGNAAVSKAESVRKFRILPTQFTEESGHLTPSLKLKRNVVAKDYADEIEALYRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K0J8</accession>
    <name>A0A2M9K0J8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GNAT family N-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_06310</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000002">
        <property type="protein sequence ID" value="PJN12639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN12639">
        <property type="protein sequence ID" value="PJN12639"/>
        <property type="gene ID" value="CG723_06310"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004343">
        <property type="term" value="F:glucosamine 6-phosphate N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006048">
        <property type="term" value="P:UDP-N-acetylglucosamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039143">
        <property type="entry name" value="GNPNAT1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13355">
        <property type="entry name" value="PTHR13355"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13673">
        <property type="entry name" value="Acetyltransf_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="10"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN12639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="168" mass="17438" checksum="54C5A3183447ED51" modified="2018-04-25" version="1">MTVPQPSSSYVVRVADSEADRKACFAVRQEVFVVEQRVPQELEYDEHDAGSGTVHVLALRADGEPLGTGRLLTGAAAVAKNGGDAGVGALGRLAVAKAARGLGVGAALVRAIEDAAAERGLVAVDLHAQTHALGFYERLGYAVYGPEFPDAGIPHRAMRKALGQPDAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-09-29" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K0T9</accession>
    <name>A0A2M9K0T9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_07000</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000002">
        <property type="protein sequence ID" value="PJN12753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN12753">
        <property type="protein sequence ID" value="PJN12753"/>
        <property type="gene ID" value="CG723_07000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="SSF50494"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014832028" evidence="1">
        <location>
            <begin position="28"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN12753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="279" mass="28986" checksum="E0E8A1A913E39C0F" modified="2018-04-25" version="1">MNKPLVGAVFGLLLIGATAAPATAVGAQHEAKAKAKAVTFAGTVALSNCSGSVVRVPDSQPTDPALVMSNGHCLESGFPGPGEVVVDQPSSRTFSLLNSAGSKVATLRADKIAYGTMTDTDVSLYQLTSTYEQIESSYGIKALELSASHPTAGTAITVVSGYWKKTYSCNIDGFAYRLKEGEWTWKDSVRYTSTCNTIGGTSGSPVVDQASGKVVAVNNTGNEDGARCTDNNPCEVDENGTVTVRKGINYAQETYGIVPCVGIGNKIDLSAAGCELPKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K0Y8</accession>
    <name>A0A2M9K0Y8_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cytochrome bc1 complex Rieske iron-sulfur subunit</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Cytochrome bc1 reductase complex subunit QcrA</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CG723_07190</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">CB01635</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Iron-sulfur subunit of the cytochrome bc1 complex, an essential component of the respiratory electron transport chain required for ATP synthesis. The bc1 complex catalyzes the oxidation of menaquinol and the reduction of cytochrome c in the respiratory chain. The bc1 complex operates through a Q-cycle mechanism that couples electron transfer to generation of the proton gradient that drives ATP synthesis.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>2Fe-2S cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49601"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000002">
        <property type="protein sequence ID" value="PJN12788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN12788">
        <property type="protein sequence ID" value="PJN12788"/>
        <property type="gene ID" value="CG723_07190"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.102.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017941">
        <property type="entry name" value="Rieske_2Fe-2S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036922">
        <property type="entry name" value="Rieske_2Fe-2S_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014349">
        <property type="entry name" value="Rieske_Fe-S_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005805">
        <property type="entry name" value="Rieske_Fe-S_prot_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10134">
        <property type="entry name" value="PTHR10134"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00355">
        <property type="entry name" value="Rieske"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00162">
        <property type="entry name" value="RIESKE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50022">
        <property type="entry name" value="SSF50022"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51296">
        <property type="entry name" value="RIESKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0408">Iron</keyword>
    <keyword evidence="8" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rieske" evidence="11">
        <location>
            <begin position="44"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00029586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PJN12788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="141" mass="14027" checksum="E83DBDB382650FB8" modified="2018-04-25" version="1">MPGTSPARRTLLRGAALAGTAGLGIAACSTGGSDGGADAAPTAPVDLGKADEVPVGGVKLYRDENVVVSRPAADKYAAFSTICTHAGCPISMLEGTELTCSCHGSKFDAETGKVLHDPATQPLAKVPVVVKNGKIVAGPEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K119</accession>
    <name>A0A2M9K119_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_07095</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000002">
        <property type="protein sequence ID" value="PJN12770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN12770">
        <property type="protein sequence ID" value="PJN12770"/>
        <property type="gene ID" value="CG723_07095"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="31"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="63"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN12770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="99" mass="10090" checksum="94A19F7BD91AD1D6" modified="2018-04-25" version="1">MEISGVISAIVIGIVIGVLGRLALPGRQRIGILATVVVGIVAALLGSAIAAGIGVADTKGVDWVEWLIQIGLAALGVALLDRGRTGGRSRGRAWGRARR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K120</accession>
    <name>A0A2M9K120_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Fe-S cluster assembly ATPase SufC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">sufC</name>
        <name evidence="6" type="ORF">CG723_07340</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CB01635</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ABC transporter superfamily. Ycf16 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000002">
        <property type="protein sequence ID" value="PJN12818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN12818">
        <property type="protein sequence ID" value="PJN12818"/>
        <property type="gene ID" value="CG723_07340"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03217">
        <property type="entry name" value="ABC_FeS_Assembly"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010230">
        <property type="entry name" value="FeS-cluster_ATPase_SufC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43204">
        <property type="entry name" value="PTHR43204"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01978">
        <property type="entry name" value="sufC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="4"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="40"/>
            <end position="47"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006216"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PJN12818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="254" mass="27735" checksum="482D23980BF7026C" modified="2018-04-25" version="1">MATLEIKDLHVTVEADNSTKEILKGVDLTVKQGETHAIMGPNGSGKSTLAYSIAGHPKYTITQGTVTLDGEDVLEMSVDERARAGMFLAMQYPVEVPGVSVSNFLRTSATAIRGEAPKLRTWVKEVKTAMEQLQMDPAFAERNVNEGFSGGEKKRHEILQMELLKPKIAILDETDSGLDVDALRQVSEGVNRVRETGEVGTLLITHYTRILRYIKPDFVHVFSQGRIVESGGPELADKLEAEGYEAYTKGGASA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K1R5</accession>
    <name>A0A2M9K1R5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Glutamate ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CG723_00195</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000001">
        <property type="protein sequence ID" value="PJN13063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN13063">
        <property type="protein sequence ID" value="PJN13063"/>
        <property type="gene ID" value="CG723_00195"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015424">
        <property type="term" value="F:ABC-type amino acid transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030679">
        <property type="entry name" value="ABC_ATPase_HisP-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039085">
        <property type="entry name" value="ABC_ATPase_HisP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="18"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="50"/>
            <end position="57"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PJN13063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="258" mass="28289" checksum="82E2057C07E54146" modified="2018-04-25" version="1">MTDVSVTKDAIPAADELVVLNQVNKHFGALHVLQDIDLTIARGEVVVVIGPSGSGKSTLCRTINRLETVDTGDITIDGKPLPQEGKELARLRADVGMVFQSFNLFAHKTVLENVMLGQIKVRRTDKKAAEAKARTLLDRVGVGTQADKYPAQLSGGQQQRVAIARALAMDPKIMLFDEPTSALDPEMINEVLEVMQQLARDGMTMIVVTHEMGFARSAANRVVFMADGRIVEEATPDQFFSNPRSDRAKDFLSKILHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K1Z3</accession>
    <name>A0A2M9K1Z3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Branched-chain amino acid transporter AzlD</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_00095</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000001">
        <property type="protein sequence ID" value="PJN13047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN13047">
        <property type="protein sequence ID" value="PJN13047"/>
        <property type="gene ID" value="CG723_00095"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008407">
        <property type="entry name" value="Brnchd-chn_aa_trnsp_AzlD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05437">
        <property type="entry name" value="AzlD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="67"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN13047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="102" mass="10167" checksum="D460CB56E565F7FD" modified="2018-04-25" version="1">MNIWIAVAVTAVGCYAVKLIGLLVPAGALERPLVRRLAALLPVALLAALTAQQTFAEGTTLVLDAKAAGLAAAAVALILRAPFLVVVAAAVVVTAGLRAVTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K216</accession>
    <name>A0A2M9K216_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_00770</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000001">
        <property type="protein sequence ID" value="PJN13161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN13161">
        <property type="protein sequence ID" value="PJN13161"/>
        <property type="gene ID" value="CG723_00770"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="56"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="81"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="122"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN13161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="155" mass="16797" checksum="E5636FCD93205515" modified="2018-04-25" version="1">MSHEPTDPPSPRPARRPWRAAARILAAAGLAVNAYVHADLASRYDPVSATISQGSLFRIETALAALAAVLVLFWRRSLGDVFAWLTAAGGLAALLVYRYVDVGAFGPLPNMYEPVWYAEKDLVVISQVLTVVAMTVLLVGRGRERLLTRRSASGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-09-29" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K258</accession>
    <name>A0A2M9K258_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Alpha-mannosidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CG723_01055</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000001">
        <property type="protein sequence ID" value="PJN13208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN13208">
        <property type="protein sequence ID" value="PJN13208"/>
        <property type="gene ID" value="CG723_01055"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005887">
        <property type="entry name" value="Alpha_mannosidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000421">
        <property type="entry name" value="FA58C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014718">
        <property type="entry name" value="GH-type_carb-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041371">
        <property type="entry name" value="GH92_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012939">
        <property type="entry name" value="Glyco_hydro_92"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00754">
        <property type="entry name" value="F5_F8_type_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07971">
        <property type="entry name" value="Glyco_hydro_92"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17678">
        <property type="entry name" value="Glyco_hydro_92N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="SSF48208"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="SSF49785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01180">
        <property type="entry name" value="aman2_put"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50022">
        <property type="entry name" value="FA58C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014967910" evidence="2">
        <location>
            <begin position="32"/>
            <end position="1269"/>
        </location>
    </feature>
    <feature type="domain" description="F5/8 type C" evidence="3">
        <location>
            <begin position="71"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="24"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="396"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1135"/>
            <end position="1183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="30"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1165"/>
            <end position="1182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PJN13208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="1269" mass="136680" checksum="630DD4D5B22FD83E" modified="2018-04-25" version="1">MDGRSRHRLKATAALGAASLALVAAGQGASAASPGQQPRVDREFSSSFETGDPAPTWLNTVDTATDGTKRSSGVDGGDSGGLPGNVNSHVTEVRASDENAGGGETKENLLDGESSTKWLSFEPTAWVEYDLDAPAKITTYALTSANDHAERDPKDWTLKGSTDGKEWTTLDTRTGESFADRFQTKKYDLQNPAEYQHFRIEFTKNNGAGDATQLADLQLATADTGSPTPDDMLSLVDKGPSGSPTAKAGAGFTGKKALRYAGTHKADSRAYSYNKVFDVDVAVARDTELSYKIFPSMADGDRDYDATNVSVDLAFTDGTYLSDLKATDSNGGLLTPQGQGAAKRLYVNQWNAVASSIGSVAAGKTVDRILVAYDSPKGPAKFRGWVDDIALKAAKQEPPKAHPADYAVTTRGTNSSGGFSRGNTFPATAVPHGFNFWTPVTNAGSLSWLYDYSRDNNADNLPTMEAFSASHEPSPWMGDRQTFQMMPSAASGTPDTSRTGRALPFKHENETARPYYYGVRFENGLKAEMTPTDHAAMLRFTYPGDDASVIFDNVSDQAGLTLDKDKGIVTGYSDVKSGLSAGATRLFVYGVFDTPVTGGDSTGPKGYLRFKPGADKAVTLRLATSLIGIDQAKANLAQELPSGSSFSSVRDSARAQWDKLLGKVEVEGATADQRTTLYSSLYRLYLYPNSGFEKVGSKYQYASPFSPMPGPDTPTHTGAKIVDGKPYVNNGFWDTYRTTWPAYSLLTPKKAGELVDGFVQQYKDGGWISRWSSPGYADLMTGTSSDVAFADAYVKGVKFDAEAAYKAALKNASVVPPAAGVGRKGMQTSPFLGYTSTDTHEGLSWALEGYLNDYGIAQMGQALYKKTGEKHYKEESEYFLNRARDYVNMFDPKAGFFQGKSEKGDWRVESSKFDPRIWGYDYTETNAWGYAFTAPQDSRGLANLYGGRDGLGKKLDTFFATPETASNDVAGSYGGVIHEMTEARDVRMGMYGHSNQVAHHITYMYDAAGQPSKTQEKVREVLSRLYTGSEIGQGYHGDEDNGEQSAWYLFSSLGFYPLVMGSGEYAIGSPQFTKMTLHLENGKDLVVKAPRNSAKNIYVQGLKVNGKNWTSTSLPHSVVAKGGVLEFAMGPKPSKWGTGKNAAPVSITQDDKVPSPRKDAITGSGPLFDNSSATSASSESVELPVGTDGAKAVQYTLTSDDRAKAPAGWKLEASADGSSWKTLDQRSGESFSWDKQTRAFSVSKPGTYKHYRLVFAGGAATVAEVELLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K2C2</accession>
    <name>A0A2M9K2C2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Indole-3-glycerol phosphate synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CG723_01400</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000001">
        <property type="protein sequence ID" value="PJN13271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN13271">
        <property type="protein sequence ID" value="PJN13271"/>
        <property type="gene ID" value="CG723_01400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PJN13271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="157" mass="17362" checksum="E9A847A005CD2CC0" modified="2018-04-25" version="1">MFTSVLMIEKALTSADVEFVTTLHGDEEVTFHVLLQPRGDQADRLLRAIDDVAMGELDDAAKERDVPEGQDATEPGEQALQVSLTALHQAGCQAEGRLVEDHPLDALKSLVDEIGADEVIVLTDPHYVEEFFHRDWASRARHKVGVPVLKLFSYSKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K2G4</accession>
    <name>A0A2M9K2G4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Aspartate aminotransferase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CG723_01695</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CB01635</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000001">
        <property type="protein sequence ID" value="PJN13319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN13319">
        <property type="protein sequence ID" value="PJN13319"/>
        <property type="gene ID" value="CG723_01695"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044249">
        <property type="term" value="P:cellular biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="CDD" id="cd00610">
        <property type="entry name" value="OAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005814">
        <property type="entry name" value="Aminotrans_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00202">
        <property type="entry name" value="Aminotran_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00600">
        <property type="entry name" value="AA_TRANSFER_CLASS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="1 2" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="14"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="17"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PJN13319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="436" mass="46740" checksum="25AEB036591C2B1D" modified="2018-04-25" version="1">MAYHKSRELFERARGSLAGGTSSSSRITTTGSEPHPLYMESGSGARIRDVDGNTYVDYLLAYGSAVLGHANPLLTDALSTVLASGTMFGTCNVPEVELAEKIRESVPCADLVRYANSGSEAVQGAIRAARGFTGRSLVVKFEGHYHGWTDTLAVSSKSTRDEVGPYEAPFAKPHSRGIPQGVLDDVVICPWNDAEVLRDVLDAHRGRIAAVVCEPIVANNACTMPVPGYLETLRAECTRRGIVLVFDEVCTGFRTGPGGAQALFGVVPDLAVYSKALGGGLPISAFVGCREIMEQVGDNRIKQGGTYNGSPLCATAALVTVTQLADPAVAGRIDEAGRRVMEAVRRASRDHGVPCAVQGVGAMFQIVFSADGAPTRHYRDLFAADLDRYERFRHELLVRGIHVNVYGLACWFVSAALEEDDIRRTCEAVNEAFAVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K323</accession>
    <name>A0A2M9K323_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Phosphoesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_02885</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000001">
        <property type="protein sequence ID" value="PJN13523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN13523">
        <property type="protein sequence ID" value="PJN13523"/>
        <property type="gene ID" value="CG723_02885"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003951">
        <property type="term" value="F:NAD+ kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017438">
        <property type="entry name" value="ATP-NAD_kinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001206">
        <property type="entry name" value="Diacylglycerol_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016064">
        <property type="entry name" value="NAD/diacylglycerol_kinase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036938">
        <property type="entry name" value="P_Acid_Pase_2/haloperoxi_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000326">
        <property type="entry name" value="P_Acid_Pase_2/haloperoxidase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00781">
        <property type="entry name" value="DAGK_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01569">
        <property type="entry name" value="PAP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00014">
        <property type="entry name" value="acidPPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00046">
        <property type="entry name" value="DAGKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111331">
        <property type="entry name" value="SSF111331"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48317">
        <property type="entry name" value="SSF48317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50146">
        <property type="entry name" value="DAGK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DAGKc" evidence="1">
        <location>
            <begin position="267"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN13523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="501" mass="52606" checksum="55FBCA3D9C15AA51" modified="2018-04-25" version="1">MCADLDHLTTWRTAPPAGPGLRGRLAALDLRVFEYAARRHWPGGDRVLPRLSRSANHGVLWFAVAGALAVGGSPKARRAAVRGVASLAVASATINTLGKRSVRRPRPVLDPVPLVRRLKRQPVTTSFPSGHAASAAAFAAGVALESRPLGALVAPLAFSVAASRVYTGAHFPGDVLAGAALGAGAAFAVRGLVPTRDQMPSPGRPLVDDVPKLPGGEGLVMVVNTGAGSPDQARTLRGLLPHAEIVEAEGSDLPAALEKAATRARALGVCGGDGTVNTAAGVALRHGLPLAVLPGGTLNHFAYDLGIEDPGDLSRAVEAGDAVAVDVGRFRSSATSGIFLNTFSLGVYPELVKERERWSRRIGGRLADVVAATHVLRRDHPLQAELDGTRRPLWMVFAGNCTYRRMGLTAGRRADLADGLLDVRVVHGGRLPGVRLLAAAFAGPLSRSPFHAAVRRTRLRMDHISPGTPLAFDGEVGSCGRELTIDKQHEALRVYRPLTIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K377</accession>
    <name>A0A2M9K377_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Peroxiredoxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CG723_02930</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000001">
        <property type="protein sequence ID" value="PJN13530.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN13530">
        <property type="protein sequence ID" value="PJN13530"/>
        <property type="gene ID" value="CG723_02930"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004601">
        <property type="term" value="F:peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015946">
        <property type="entry name" value="KH_dom-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003718">
        <property type="entry name" value="OsmC/Ohr_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036102">
        <property type="entry name" value="OsmC/Ohrsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019904">
        <property type="entry name" value="Peroxiredoxin_OsmC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02566">
        <property type="entry name" value="OsmC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82784">
        <property type="entry name" value="SSF82784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03562">
        <property type="entry name" value="osmo_induc_OsmC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PJN13530.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="141" mass="14202" checksum="C15A5E0A4504FD22" modified="2018-04-25" version="1">MATTRSAHTVWEGDLLKGSGLVTFDSSGIGQQAVSWASRAEQANGKTSPEELIAAAHSSCFSMALSNGLATGGNPPTKLVTSADVTFQPGEGITGIHLTVEGTVPGLDEAGFAAAAEDAKKNCPVSQALTGTTITLTAKLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K3D5</accession>
    <name>A0A2M9K3D5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Carnitine dehydratase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CG723_03255</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000001">
        <property type="protein sequence ID" value="PJN13590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN13590">
        <property type="protein sequence ID" value="PJN13590"/>
        <property type="gene ID" value="CG723_03255"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10540">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003673">
        <property type="entry name" value="CoA-Trfase_fam_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044855">
        <property type="entry name" value="CoA-Trfase_III_dom3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023606">
        <property type="entry name" value="CoA-Trfase_III_dom_1_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02515">
        <property type="entry name" value="CoA_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89796">
        <property type="entry name" value="SSF89796"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PJN13590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="410" mass="43645" checksum="372FE4D491557E77" modified="2018-04-25" version="1">MTDPLPLEGITVVSLEQAVAAPFATRQLADLGARVIKVERPGGGDFARRYDTTVHGQASYFVWLNRSKESLTLDLKSQEGRDILEELLADADVFVQNLAPGAADRMDLGPAALQARHPRLIPCTISGYGTSGSWSQRKAYDLLVQCQTGLLSITGSPDEPARVGISVADIAAGMYAYSGVLSALYTRATTGRAPAVEVSLFEALAEWMSQPAYYTRYGGTQPPRIGAQHATIAPYGPFTASDGKEVLLSIQNEREWQALCSTVLGRPELTDDPRMATGADRVAHRDEVNAAVSARFAELGSEDAMALLDKAGIANAGVNSIAEFLAHPALAERDRWRDIAVPGAQGPVQALLPPADLSGVTPRMDPVPAAGEHTEQILSALGRSAADIERLRAQGVIDTTHDHEQGASAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K3G5</accession>
    <name>A0A2M9K3G5_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Transport permease protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CG723_03740</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CB01635</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the ABC-2 integral membrane protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000001">
        <property type="protein sequence ID" value="PJN13668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN13668">
        <property type="protein sequence ID" value="PJN13668"/>
        <property type="gene ID" value="CG723_03740"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046677">
        <property type="term" value="P:response to antibiotic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC_2_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000412">
        <property type="entry name" value="ABC_2_transport"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01061">
        <property type="entry name" value="ABC2_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51012">
        <property type="entry name" value="ABC_TM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0046">Antibiotic resistance</keyword>
    <keyword evidence="8" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="76"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="108"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="154"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="182"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="218"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="280"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="domain" description="ABC2_membrane" evidence="10">
        <location>
            <begin position="60"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PJN13668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="309" mass="33842" checksum="8640C6E6189F75B7" modified="2018-04-25" version="1">MSETTHDGGVAVTARPSPDEGLSPADLAAKYGLTVSGARPGLFEYVSQLWGRRHFILAFSQAKLTAQYSQAKLGQLWQVATPLLNAAVYYLIFGLILHASRGMSMDVYIPFLVTGVFVFTFTQSSVMAGVRAISGNLGLVRALHFPRASLPISFALQQLQQLLFSMIVLFVVAIGFGSYPGLSWLLIIPVLALQFLFNTGLALIMARLGSKTPDLAQLMPFVMRTWMYASGVMFSIPIMLADKPAWVADILQWNPAAIYMDLMRFALIDGYDSGNLPPHVWAVAAGWSVLVAAGGFVYFWKSEERYGRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K3S8</accession>
    <name>A0A2M9K3S8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_03280</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000001">
        <property type="protein sequence ID" value="PJN13788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN13788">
        <property type="protein sequence ID" value="PJN13788"/>
        <property type="gene ID" value="CG723_03280"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="47"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="76"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="119"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN13788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="407" mass="44794" checksum="753CFEDA90091F54" modified="2018-04-25" version="1">MSRRRQFPEPRRAAAHPQDDGRARPCRLRHRVRRLVPEEHLRPVLGHQRPRHVPRQHAHDHPARHGRAVRRPALRRRPRQPLEHPQGRHRPARPRDPGHAPALLADLDPQFRPHPARHGHREAAARHVLRTPRRHARPGVPRPRPLHRHLGVVLRGRDALRRRHAPHRSGAAHRHGVDRARRGLRRPDGAALALRRPCPSRAYGGCRGAGRQGGRRDAAAACDVTDADAVKAAVRGCVERFGSLDAMVNNAGITRDATLRKMSEADFDAVVDVHLKGAWLGTRAAAEVMREQGSGSIVNISSISGKVGMVGQTNYSAAKAGLVGLTKAAAKELAHRGVRVNAVQPGLIRTEMTESLREDIWNAKLAEVPMRRAGEPEEVAGTVLFLASDLSSYTTGCVLEVAGGRSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JEL5</accession>
    <name>A0A2M9JEL5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_45350</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000053">
        <property type="protein sequence ID" value="PJN05331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN05331">
        <property type="protein sequence ID" value="PJN05331"/>
        <property type="gene ID" value="CG723_45350"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005025">
        <property type="entry name" value="FMN_Rdtase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023932">
        <property type="entry name" value="Uncharacterised_CE1759"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03358">
        <property type="entry name" value="FMN_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52218">
        <property type="entry name" value="SSF52218"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04037">
        <property type="entry name" value="LLM_duo_CE1759"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FMN_red" evidence="1">
        <location>
            <begin position="1"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN05331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="199" mass="20806" checksum="C61C7BE504C392A2" modified="2018-04-25" version="1">MKLVVVSAGLSAPSSSRILADRLTQAVTSQVSGADVDVTVVELRDLAVEIAHNLVTGFPGPALKEALDAVAGADGLIAVSPVFSASYSGLFKSFFDVLDKDVLTGKPVLVGATGGTPRHSLVLEHAMRPLFAHLRAVVVPTAVYAASQDWGAEGLEQRVERAGGELARLMTGLAAARPAPVEWGDDVIPFERRLAALRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JEQ9</accession>
    <name>A0A2M9JEQ9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CG723_45335</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000052">
        <property type="protein sequence ID" value="PJN05359.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN05359">
        <property type="protein sequence ID" value="PJN05359"/>
        <property type="gene ID" value="CG723_45335"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PJN05359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="59" mass="5989" checksum="27E55292FA211222" modified="2018-04-25" version="1">MTITYDQAGGNNGGGGGGSILPVNLSGVIPMFNNISINHNIKSPGATNNTTQDFDLNAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-06-02" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JEX1</accession>
    <name>A0A2M9JEX1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CG723_45165</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000051">
        <property type="protein sequence ID" value="PJN05362.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN05362">
        <property type="protein sequence ID" value="PJN05362"/>
        <property type="gene ID" value="CG723_45165"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004525">
        <property type="term" value="F:ribonuclease III activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016772">
        <property type="term" value="F:transferase activity, transferring phosphorus-containing groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1520.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014720">
        <property type="entry name" value="dsRBD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000999">
        <property type="entry name" value="RNase_III_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036389">
        <property type="entry name" value="RNase_III_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00035">
        <property type="entry name" value="dsrm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00358">
        <property type="entry name" value="DSRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69065">
        <property type="entry name" value="SSF69065"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50137">
        <property type="entry name" value="DS_RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50142">
        <property type="entry name" value="RNASE_3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0540">Nuclease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="DRBM" evidence="5">
        <location>
            <begin position="135"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="domain" description="RNase III" evidence="6">
        <location>
            <begin position="232"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="4">
        <location>
            <begin position="743"/>
            <end position="950"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PJN05362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="957" mass="101718" checksum="1BA2C00CA22096B0" modified="2018-04-25" version="1">MALTHSSYLHEHRDLFPGVTRSLLNVLQRLGMEYLRKQATVEIFRRGGVQTAGSLSKGVGLVPPVVQSWSTRQEWINQSCAVGGSLTGGPLPARSAAELCYQVVGVLCLAGEETAAAALVGRLIAAADEGGSIADPKTELQERLQGSRTNGSAVYKYQREGPEHALTFRAVVTDSRGRRGTGVGPSKKRASQQAALDFLRRYVPEALGTRNVAAPRLVPAQIPLQQSHARVVRHLQDLFSLTAEARPLLSQALIHSSWAYEHREVLAACRQQDNQVLGFVGSQVLNYEHALDSVRRVLPDPPEELSLLTLPNEVHDGAFRHVGLESGLLLGAGQASLGIPAEMGANAFQAVIGAVFVARGFPDSLHPTWPRQWEPVWRMVAPEIPRKQDPTTLLQQAASAMKLQIGFSYRMSGPDHATEQHATVTLSSTELGTETQIEGAWIGARPKAKHQASQAVLTVLDKLAACRPSEDLRSEGPTARSVGRFLLSHQAAVLAVHRVPVRRWVDARLFGLHWAASPADLLSWAQEADELISGTVDFRPSISHIEQAFRAASELAAGSQVAIEPELAAVLDILEGLHTPDALTADQLQRLVQLADLCRCLGSDDLGVDLRELADDWGLLHRGGLLVPRLLPGMRLSGRERAILDAGASAVLASGTSASVEVLSSSPLRLRFLAGAPLDPAAGKRMCTLWSSVSRTAMLTLNERGIDATILTTADPTSAGPITRAARAALQPAARPYQAAVADLLHDLKNQLVAARLADSSPAETRTARLQQQLAASRHLDQAHALAARLRSTTSLLGPTGTESVDIGSFLRHYASGVLTRLPGSISLSIPDAPRSVRVALDEGGLTAVLDNLVGNAIEALPGGGSITLEWTADDDEAVVEITDDGPGLPPEVVAALVAGERVRSTKPGGNGLGLLGVQSLLNRAGGELTTVPAPSGTGTAWLITLPIAPTTTTEDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JEY5</accession>
    <name>A0A2M9JEY5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_44780</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000048">
        <property type="protein sequence ID" value="PJN05461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN05461">
        <property type="protein sequence ID" value="PJN05461"/>
        <property type="gene ID" value="CG723_44780"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038721">
        <property type="entry name" value="IS701-like_DDE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13546">
        <property type="entry name" value="DDE_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDE_5" evidence="2">
        <location>
            <begin position="22"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="429"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="463"/>
            <end position="480"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN05461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="480" mass="53314" checksum="148F332CD36A1428" modified="2018-04-25" version="1">MSVSASGSAGDGLEVLSRFRVEFYDCLYARADALFELTDAILCKDGPVQTLVDLSLEAEHRRGHGALYQALNAGWAEPARLRGLLASLPVPRAVDGRIVLAVDVSTWLRPDAETSSDRLFCHVYGRGRSKDQFIPGWPYSFVAVLESGRTSWCRLLDAVRLGPADDAAAVTAAQLRDIVMQLIAAGHWSDGAPELLIVADAGYDLARLAHLLADLPVEVCGRLRSDRVMARDPAPHNARPRPGRPRMHGAPFALARPTTWGDPQTETRTDTTRYGTATATAWDRLHPRLTRRSAWITDRNAELPILHGLVVRLNVERLPGGRDPDPVWLWSSRPGADAAHVDQLWRAYLRRFDLEHTFRLLKQTLGWTVPKLRDPANADLWTTLIIAAHTQLWLARPAAQDLRHPWERPLAAHKLTPARVRRGFRNIRAKTARPAAAPKPSHPGPGRPRGSRNHTRAPRHVPGKTVKRAETLDQHYGRTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JF47</accession>
    <name>A0A2M9JF47_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">HIT family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_44625</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000048">
        <property type="protein sequence ID" value="PJN05442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN05442">
        <property type="protein sequence ID" value="PJN05442"/>
        <property type="gene ID" value="CG723_44625"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.428.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001310">
        <property type="entry name" value="Histidine_triad_HIT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011146">
        <property type="entry name" value="HIT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036265">
        <property type="entry name" value="HIT-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46648">
        <property type="entry name" value="PTHR46648"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01230">
        <property type="entry name" value="HIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00332">
        <property type="entry name" value="HISTRIAD"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54197">
        <property type="entry name" value="SSF54197"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51084">
        <property type="entry name" value="HIT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HIT" evidence="2">
        <location>
            <begin position="4"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Histidine triad motif" evidence="1">
        <location>
            <begin position="91"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN05442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="145" mass="16031" checksum="5EC7265EEF5604D0" modified="2018-04-25" version="1">MTTVFSRIIVGELPGRFVWQDPEIVAFLSIAPLRPGHTLVVPRREVDRWTDADGTLLARCFEVAQAIGQGVQRAWNAPRAGLVIAGFEVPHLHIHVAPVWDMSDFDFSKAKQEEDQSALAEAAAKLRAALLELGYEQARDFDPGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-09-29" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JFH2</accession>
    <name>A0A2M9JFH2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">E9imm peptide</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CG723_44015</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000045">
        <property type="protein sequence ID" value="PJN05572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN05572">
        <property type="protein sequence ID" value="PJN05572"/>
        <property type="gene ID" value="CG723_44015"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035900">
        <property type="entry name" value="Colicin_E_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PJN05572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="76" mass="8362" checksum="D4CFA6ACA5A8D16F" modified="2018-04-25" version="1">MGAVELSRAEAVALVQRIMEADYASEGEVNDWLDRLDRALACPSGHVSGLVFWPPQRELSAEEVVDHALAYRPIAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JFH6</accession>
    <name>A0A2M9JFH6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Amidohydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_44505</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000047">
        <property type="protein sequence ID" value="PJN05507.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN05507">
        <property type="protein sequence ID" value="PJN05507"/>
        <property type="gene ID" value="CG723_44505"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04909">
        <property type="entry name" value="Amidohydro_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydro-rel" evidence="1">
        <location>
            <begin position="9"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN05507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="288" mass="32144" checksum="4F48FAB8569663A4" modified="2018-04-25" version="1">MTARHAVRIDAHQHFWDPKRFTYPWMEGAVLDPVRRPFTPDDLAQDLATHGIDGTVLVQTVSALPETRMFLDIARETPFVHGVVGWVDLTAPDVGDELDELLEEYGRLLVGIRHQVHDEDDPHWLDRPDVRHGLREIAARGLVYELLVRTRELPAATATVAALPDLHFVLDHIAKPHIAAGWDDPWASAVARLAEHPNVDVKLSGMVTEADWQDWTPRTLQPFVDHILSAFTVQRVMFGSDWPVCLLAAGSYSDVADALADTLGGLSAAENEQVFGRNAQQRYRLPGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JFJ6</accession>
    <name>A0A2M9JFJ6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GntR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_43365</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000043">
        <property type="protein sequence ID" value="PJN05654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN05654">
        <property type="protein sequence ID" value="PJN05654"/>
        <property type="gene ID" value="CG723_43365"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07377">
        <property type="entry name" value="WHTH_GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
        <property type="entry name" value="GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00035">
        <property type="entry name" value="HTHGNTR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00345">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50949">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH gntR-type" evidence="1">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN05654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="100" mass="10758" checksum="AC63C2E27F198DFF" modified="2018-04-25" version="1">MQVADALRDDIKKMKPGEKLPSQRELMDRFGYASQTIQNGLAALRTEGLIVSAGNLGNFVSDGSAPGGDVRDDIKEIRSQLKTLTERLEALESRSVPGGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JFQ4</accession>
    <name>A0A2M9JFQ4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Short-chain dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CG723_43090</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000042">
        <property type="protein sequence ID" value="PJN05718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN05718">
        <property type="protein sequence ID" value="PJN05718"/>
        <property type="gene ID" value="CG723_43090"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PJN05718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="250" mass="26459" checksum="9750020C2859FFD8" modified="2018-04-25" version="1">MTDPSGDAGTVVVTGAGRGLGLAMARRAAEDGFRVVVAELDTERGTHAAEELRGDGLDAHFVRCDVADPESVDELAGRVRELGPLYGLINNAALANGVGGKEFQDIDVEVWDRLMTVNARSPWLVSKALYPLFGSPGRIVNVASDAALYGSPRLAHYIASKGAVIALTRAMARELGDKGITVNAVAPGLTECEATETVPEERHELYRSGRAISRPQEPGDLIGLVAFLLGEESRYLTGQVIAVNGGFTMN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JFY1</accession>
    <name>A0A2M9JFY1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">SMC-Scp complex subunit ScpB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">scpB</name>
        <name evidence="5" type="ORF">CG723_42870</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000041">
        <property type="protein sequence ID" value="PJN05805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN05805">
        <property type="protein sequence ID" value="PJN05805"/>
        <property type="gene ID" value="CG723_42870"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051304">
        <property type="term" value="P:chromosome separation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005234">
        <property type="entry name" value="ScpB_csome_segregation"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34298">
        <property type="entry name" value="PTHR34298"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04079">
        <property type="entry name" value="SMC_ScpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF019345">
        <property type="entry name" value="ScpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00281">
        <property type="entry name" value="TIGR00281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="1" id="KW-0132">Cell division</keyword>
    <keyword evidence="2" id="KW-0159">Chromosome partition</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="187"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PJN05805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="214" mass="23430" checksum="BFF7859647F8EE89" modified="2018-04-25" version="1">MSGQEVVAGADRVAELDLRPALEAVLMVVDEPATEEHLAKILDRPRRAVADALRALADEYTVQGRGFELRLVAGGWRFYTRPQYAAAVERFVLDGQQARLTQAALETLAVVAYRQPVSRSRVSAVRGVNCDGVMRTLLQRGLVEEAGAEPETSAILYRTTNYFLERMGLRGLDELPELAPFLPEADAIEAETQEGVPSFDPDAPDAPGYEDADD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JG93</accession>
    <name>A0A2M9JG93_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">GtrA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CG723_42305</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CB01635</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GtrA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000039">
        <property type="protein sequence ID" value="PJN05898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN05898">
        <property type="protein sequence ID" value="PJN05898"/>
        <property type="gene ID" value="CG723_42305"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000271">
        <property type="term" value="P:polysaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007267">
        <property type="entry name" value="GtrA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04138">
        <property type="entry name" value="GtrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="27"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="61"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="91"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="125"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="domain" description="GtrA" evidence="7">
        <location>
            <begin position="29"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PJN05898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="155" mass="17029" checksum="BF884FC0E751FF7F" modified="2018-04-25" version="1">MTVQTAAREAPVVVPVRVRVRRLSMEVAKFGAVGGSGVAVNFLVFNLLLHGIGRAPMTATVLASCVAMGTNYLGFRFFAYRDRDSRTRRQIALFFGFSALGVLMESVLFYAGYHGASMTGPLASNIAKALSIVLASAFRFLVYRTWVFQHDARRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JGJ2</accession>
    <name>A0A2M9JGJ2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Choline oxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CG723_41880</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CB01635</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 3">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GMC oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000037">
        <property type="protein sequence ID" value="PJN05998.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN05998">
        <property type="protein sequence ID" value="PJN05998"/>
        <property type="gene ID" value="CG723_41880"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012132">
        <property type="entry name" value="GMC_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000172">
        <property type="entry name" value="GMC_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007867">
        <property type="entry name" value="GMC_OxRtase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552">
        <property type="entry name" value="PTHR11552"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05199">
        <property type="entry name" value="GMC_oxred_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00732">
        <property type="entry name" value="GMC_oxred_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000137">
        <property type="entry name" value="Alcohol_oxidase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00624">
        <property type="entry name" value="GMC_OXRED_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GMC_OxRdtase_N" evidence="4">
        <location>
            <begin position="257"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="82"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000137-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS00624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PJN05998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="514" mass="55623" checksum="CE438BCE8C0BF913" modified="2018-04-25" version="1">MDEFDYVVVGGGTAGAVVAARLSEDPAVTVCVLEAGPSDVGDDSILRLERWMALLESGYDWDYPVEPQENGNSFMRHARGKVLGGCSSHNSCIAFWAPAEDLDEWGALGCTGWSAADCYPLYQRLETNDAPGDHHGRSGPVTIRTIPPNDPCGTALLAACADAGIPTTPFNTGSTVVRGAHWFQINAREDGTRSSASVSYLHPILDSRPNLAIRTGLQAKSLRFDDSNRCTGVDYLEPDTIHSGSVAARREVIVSCGAIDSPKLLMLSGIGPAGDLRDCGVDVRVDSPGVGSHLQDHPEGVIMWEAKQPMVTRSTQWWEIGIFAGTEPGLDRPDLMFHYGSVPFDMNTYRRGYPTTDNAFCLTPNVTRARSMGTVRLRTRDFRDKPRVDPRYFTDEHDIRVMIHGLRLAREITAQAPMAAWAGAELAPGPAAQSDDELFSYIKETHNTVYHPAGTVRMGSASDADSPLDPQLRVKGVSGLRVADASVMPFLPAVNPCITTMMIGEKCADMIKAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JGM1</accession>
    <name>A0A2M9JGM1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">MarR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CG723_41985</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000038">
        <property type="protein sequence ID" value="PJN05907.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN05907">
        <property type="protein sequence ID" value="PJN05907"/>
        <property type="gene ID" value="CG723_41985"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000835">
        <property type="entry name" value="HTH_MarR-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025246">
        <property type="entry name" value="IS30-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13936">
        <property type="entry name" value="HTH_38"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12802">
        <property type="entry name" value="MarR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH_38" evidence="3">
        <location>
            <begin position="5"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="domain" description="HTH marR-type" evidence="2">
        <location>
            <begin position="119"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="33"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="55"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PJN05907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="244" mass="26826" checksum="3E3CDD04F50C949D" modified="2018-04-25" version="1">MPGGRLTQPERQQIALGLAGGLAYAEIARTLDRPTSTVTREVMRNGGPTAYRADLVHRATEHRARRKQSAPRDPGTPPQPHGRDAEAVRAYEETFTTVLIQSGTPKMMARVMACLTLTDTGSLTAAELVQRLQVSPASISKAVAFLESQGMVRRERDERRRERYVVDNDIMYQSMMASARSTAHVVDIARQGVGVLGSGTPAATRLENIGRFLDFVSERIARAAEQARDILHTQPEPPKDHTTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JH06</accession>
    <name>A0A2M9JH06_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Abi_C domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_41050</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000035">
        <property type="protein sequence ID" value="PJN06132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN06132">
        <property type="protein sequence ID" value="PJN06132"/>
        <property type="gene ID" value="CG723_41050"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026001">
        <property type="entry name" value="Abi-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14355">
        <property type="entry name" value="Abi_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Abi_C" evidence="2">
        <location>
            <begin position="191"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="286"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN06132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="309" mass="33336" checksum="4AE73CF5C48C8576" modified="2018-04-25" version="1">MVTADRELLSRTARNAVRGLMSDLVAGAIGEYWENEHFAPAPGFTRVEGGVRKQLFDSYAASVDWTDHDHVTRALRVFESMLRRLDRESRKYGGDGLPADTVADLREAFARDGCRLDDELRLHTARVAHLVVHADALSEASGIQAELERVRRFGADYPDDAIGAAKQLIEATAKLVLLKRNLPVDERQDLPALIKQAQQALHLHPAAVPPARTGGSPDNADSIKRILGALTSAAIGVAELRNRYGTGHGRLAAPTGLGPRHARFAVGTAATWCELMLDTLADPNAPWRKAPSTPAPLADSADSEPAASI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JH48</accession>
    <name>A0A2M9JH48_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">C4-dicarboxylate ABC transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CG723_40610</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CB01635</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000034">
        <property type="protein sequence ID" value="PJN06206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN06206">
        <property type="protein sequence ID" value="PJN06206"/>
        <property type="gene ID" value="CG723_40610"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004680">
        <property type="entry name" value="Cit_transptr-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009827">
        <property type="entry name" value="MatC_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03600">
        <property type="entry name" value="CitMHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07158">
        <property type="entry name" value="MatC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="44"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="89"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="137"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="172"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="226"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="269"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="307"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="390"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="domain" description="MatC_N" evidence="8">
        <location>
            <begin position="1"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="domain" description="CitMHS" evidence="7">
        <location>
            <begin position="241"/>
            <end position="398"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF03600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF07158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PJN06206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="414" mass="43124" checksum="AF34C5AE50217B73" modified="2018-04-25" version="1">MISVGALLVMFVVGTVLPINIGILAFVACFAVGTTALNMTEEQIFEGFPVELFLTIVGVTYLFAVARRNGTVDLLVAAGVRLVRGQTALIPWVLFLLAGVLTSLGTFTPAAVAILVPIGMNFAFRHNINPLMTGMMVISGAHAGAFSPMAVSGALVLGMVDDTDLSVAPATLFFASFAVNLLLSLLTFAALRRRTMAADSSAQPEQEAPDGDADTERATWHQWATLAALAALVVCALGFQMQIGVLALAAGALLALLDMKRQEKAVDGISWHTLLLVGGMMTYIAMLEHAGIIEKISEHAAGFGTPLVVALLLCFTVAVTSAFASSTAILTAIIPIAVPLLLSSHLSSTGLIAALAVSTTIVDVSPFSTNGALVLSNARGVERRGFYRQILGYTCGIVAAGPVVAWGALVLPWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JH83</accession>
    <name>A0A2M9JH83_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Aldolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_40030</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000033">
        <property type="protein sequence ID" value="PJN06212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN06212">
        <property type="protein sequence ID" value="PJN06212"/>
        <property type="gene ID" value="CG723_40030"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005000">
        <property type="entry name" value="Aldolase/citrate-lyase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_Kinase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040442">
        <property type="entry name" value="Pyrv_Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03328">
        <property type="entry name" value="HpcH_HpaI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="SSF51621"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HpcH_HpaI" evidence="1">
        <location>
            <begin position="112"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN06212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="430" mass="45792" checksum="7DD77E36AD02FD96" modified="2018-04-25" version="1">MGQQEKVATSLAGAVSEGISASLAPVDAELERRYPGDPGTRQPVHTVYVPGEQFDADTIRTWGDKALAMLDEHAPDAASFAAVLGLGDDLAEAVHTRVRAKLEREPVEDLRIDFEDGYKGADEDQDAARAARLVAEAYKNGTAAPYMGIRMKCMEAPVRDRGIRTLDIFLSGLMEAGGLPDGLVLTLPKVTYPEQVTAMVRLLEAFEKAHGLEAGRLGFEIQIETSQSILAADGTAAVARMIDAAEGRATGLHYGTFDYSACLGVSAAYQASDHPAADYAKAVMQVAAAGTGVRVSDGSTNVLPVGTTAKVHDAWRLHYGLTRRALARAYYQGWDMHPGHIPTRYAAVFAFYREGFESAAARLAAYAGHHEGGDVADEPATAKALAGYLLRGLDCGALDTGEVTRITGLTLARLQGFAGPRRGDLTAQER</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JHC2</accession>
    <name>A0A2M9JHC2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CG723_40405</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CB01635</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the class I-like SAM-binding methyltransferase superfamily. Cation-independent O-methyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000033">
        <property type="protein sequence ID" value="PJN06280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN06280">
        <property type="protein sequence ID" value="PJN06280"/>
        <property type="gene ID" value="CG723_40405"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008171">
        <property type="term" value="F:O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016461">
        <property type="entry name" value="COMT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001077">
        <property type="entry name" value="O_MeTrfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00891">
        <property type="entry name" value="Methyltransf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005739">
        <property type="entry name" value="O-mtase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51683">
        <property type="entry name" value="SAM_OMT_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransf_2" evidence="3">
        <location>
            <begin position="114"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="205"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PJN06280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="342" mass="37403" checksum="AB7273A47C33844B" modified="2018-04-25" version="1">MTTVEEAPQSPMRLRELVFGAACAAAVRAAARLGVADALDDTPMSAEDLAAAVKTQPLTLRRLLRALSSQGVFTELPDGTFAHTDMSRLLREDDPHSLRYIALWCTEPWTWNVWPKLDEAVRHGRNVFEDVYEAEFFTYLNQQAPESAHVFNRAMTTSSEQSARDVADLLDLTGVASVADIGGGHGQVVASLLEKHPDMHGTLLDLPGVVENADPRLRDGGSLASRVRIVAGDCREDIPVQADVYIIKNILEWDDDSTRRALANVRKAARPGARVVVIENLVDDTPSMKFTTSMDLLLLLNVGGAKHTRLSMVERLTDAGLVLGEVRPVNAYLHAFECTVPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-09-29" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JI53</accession>
    <name>A0A2M9JI53_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Chitinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CG723_38345</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CB01635</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the glycosyl hydrolase 18 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000028">
        <property type="protein sequence ID" value="PJN06565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN06565">
        <property type="protein sequence ID" value="PJN06565"/>
        <property type="gene ID" value="CG723_38345"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011583">
        <property type="entry name" value="Chitinase_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001223">
        <property type="entry name" value="Glyco_hydro18_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001579">
        <property type="entry name" value="Glyco_hydro_18_chit_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00704">
        <property type="entry name" value="Glyco_hydro_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00636">
        <property type="entry name" value="Glyco_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01095">
        <property type="entry name" value="GH18_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51910">
        <property type="entry name" value="GH18_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="1 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014670473" evidence="5">
        <location>
            <begin position="35"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="domain" description="GH18" evidence="6">
        <location>
            <begin position="46"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU004453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PJN06565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="335" mass="34247" checksum="7B618DA77B611E41" modified="2018-04-25" version="1">MARATTKPARKRSFLAAALTTLALALTGTATATADPAGADAAPPAHAVTGYWQNFNNGAAVQKISDVPGDYDIIAVAFADATTTPGAVDFTLDSAGLGGYTEDAFKADIKAKQAAGKSVVISIGGQNGTVSINDSNSATNFANSVYSLMQEYGFNGVDIDLENGLNSTYMSQALKSLASKAGSDFVLTMAPQTIDMQSTSAEYFKTALAVKDILTVVNMQYYNSGSMLGCDGKVYSQGSVDFLTALACIQLEGGLAPSQVGLGVPASTSAAGSGYVSPSVANAALDCLTKGTNCGSFKPSKTYPGLRGAMTWSTNWDASTGNGWSSSVGPHVHGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JJ05</accession>
    <name>A0A2M9JJ05_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 9">Urocanate hydratase</fullName>
            <shortName evidence="9">Urocanase</shortName>
            <ecNumber evidence="4 9">4.2.1.49</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8 9">Imidazolonepropionate hydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">hutU</name>
        <name evidence="13" type="ORF">CG723_36920</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">CB01635</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the conversion of urocanate to 4-imidazolone-5-propionate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>4-imidazolone-5-propanoate = H2O + trans-urocanate</text>
            <dbReference type="Rhea" id="RHEA:13101"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17771"/>
            <dbReference type="ChEBI" id="CHEBI:77893"/>
            <dbReference type="EC" id="4.2.1.49"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </cofactor>
        <text evidence="9">Binds 1 NAD(+) per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 9">Amino-acid degradation; L-histidine degradation into L-glutamate; N-formimidoyl-L-glutamate from L-histidine: step 2/3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the urocanase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.49" evidence="4 9"/>
    <dbReference type="EMBL" id="NNBL01000025">
        <property type="protein sequence ID" value="PJN06865.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN06865">
        <property type="protein sequence ID" value="PJN06865"/>
        <property type="gene ID" value="CG723_36920"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00379">
        <property type="reaction ID" value="UER00550"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016153">
        <property type="term" value="F:urocanate hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019556">
        <property type="term" value="P:histidine catabolic process to glutamate and formamide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019557">
        <property type="term" value="P:histidine catabolic process to glutamate and formate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10730">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00577">
        <property type="entry name" value="HutU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023637">
        <property type="entry name" value="Urocanase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035401">
        <property type="entry name" value="Urocanase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038364">
        <property type="entry name" value="Urocanase_central_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023636">
        <property type="entry name" value="Urocanase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035400">
        <property type="entry name" value="Urocanase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035085">
        <property type="entry name" value="Urocanase_Rossmann-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036190">
        <property type="entry name" value="Urocanase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12216">
        <property type="entry name" value="PTHR12216"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01175">
        <property type="entry name" value="Urocanase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17392">
        <property type="entry name" value="Urocanase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17391">
        <property type="entry name" value="Urocanase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001423">
        <property type="entry name" value="Urocanate_hydrat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111326">
        <property type="entry name" value="SSF111326"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01228">
        <property type="entry name" value="hutU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01233">
        <property type="entry name" value="UROCANASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 9" id="KW-0369">Histidine metabolism</keyword>
    <keyword evidence="7 9" id="KW-0456">Lyase</keyword>
    <keyword evidence="6 9" id="KW-0520">NAD</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Urocanase_N" evidence="11">
        <location>
            <begin position="7"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="domain" description="Urocanase" evidence="10">
        <location>
            <begin position="136"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="domain" description="Urocanase_C" evidence="12">
        <location>
            <begin position="346"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="405"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="48"/>
            <end position="49"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="126"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="172"/>
            <end position="174"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="192"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="197"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="238"/>
            <end position="239"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="259"/>
            <end position="263"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="268"/>
            <end position="269"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="317"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="487"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000607"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF17391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF17392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PJN06865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="554" mass="60160" checksum="32456711635AEA72" modified="2018-04-25" version="1">MSGPRPVRAPRGTELNTLGWQQEGALRMLMNNLDAEVAEHPDKLVVYGGTGKAARSWEAFDAIVRTLKTLKADETLLVQSGKPVGVMRTHEWAPRVLLANSNLVGDWANWEEFRKLEAEGLTMYGQMTAGSWIYIGSQGIVQGTYETFGAVARKKFNGTLAGTITLTAGVGGMGGAQPLAVTMNEGVAICVDVDETRIDRRIGTRYLDVKADNLDHALELAVQARDERRGLSIGVVGNAAEIFPELLRREAPIDIVTDQTSAHDPLAYLPVGISVEDWDKEREADPAGFTDKARHSMRLHVEAMIGFLDRGAEVFDYGNSIRDEARKAGCERAFDFPGFVPAHIRPLFEEGLGPFRWAALSGDPEDIAKTDKAIKELFPENKHLHRWIDMAAERIAFEGLPARICWLGYGERHLAGLKFNEMVASGELSAPVAIGRDHLDSGSVASPYRETEAMKDGSDAIADWPLLNALVNTASGASWVSIHHGGGVGMGRSIHAGQVCVADGTELAAQKIERVLTNDPAMGVIRHVDAGYEHAAEVAAERGVRVPMREGDDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JJ20</accession>
    <name>A0A2M9JJ20_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Anti-sigma factor antagonist</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CG723_36945</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CB01635</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the anti-sigma-factor antagonist family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000025">
        <property type="protein sequence ID" value="PJN06868.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN06868">
        <property type="protein sequence ID" value="PJN06868"/>
        <property type="gene ID" value="CG723_36945"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043856">
        <property type="term" value="F:anti-sigma factor antagonist activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.750.24">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003658">
        <property type="entry name" value="Anti-sigma_ant"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002645">
        <property type="entry name" value="STAS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036513">
        <property type="entry name" value="STAS_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13466">
        <property type="entry name" value="STAS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52091">
        <property type="entry name" value="SSF52091"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00377">
        <property type="entry name" value="ant_ant_sig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50801">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="STAS" evidence="3">
        <location>
            <begin position="14"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PJN06868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="122" mass="12764" checksum="41FCB7B398E80482" modified="2018-04-25" version="1">MDRGTVGSAHRGRLLVEVREEGASAVVTPVGELDHHTADLLREPLESCLTAGFSRLVIDCSRLEFCDSTGLNVLLGARLKAEAAGGGVHLAGMLPVVARVFEITGAEAVFTVHESLDAALGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-06-02" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JK42</accession>
    <name>A0A2M9JK42_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_35165</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000022">
        <property type="protein sequence ID" value="PJN07232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN07232">
        <property type="protein sequence ID" value="PJN07232"/>
        <property type="gene ID" value="CG723_35165"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GFO_IDH_MocA" evidence="1">
        <location>
            <begin position="1"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN07232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="301" mass="33021" checksum="D8F5EC6DFCCE86A4" modified="2018-04-25" version="1">MKVGCIGLGDIAQKAYLPVLTTLPGVELHLQTRTPATLQLVGDTHHIPAERRHTDLDALLAHGLDAAFVHAPTAVHPEIVTRLLEAGVATYVDKPLAYELADSQRLVRLAEERGVSLTVGFNRRHAPGYTQCAEHPRELILMQKNRIGLPEDPRTLVLDDFIHVVDTLRYLVPGPIDDVSVRARVEDGLLHHVVLQLGGDGFTAIGVMNRLSGSTEEILEVSGQDTKRQVVNLAEVIDHKGQPTVRRRGDWVPVARQRGIEQVVLGFLDGVRAGKVLSAKDALETHVLCEQVVREVQQFAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JKQ0</accession>
    <name>A0A2M9JKQ0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CG723_33565</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000020">
        <property type="protein sequence ID" value="PJN07432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN07432">
        <property type="protein sequence ID" value="PJN07432"/>
        <property type="gene ID" value="CG723_33565"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PJN07432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="88" mass="9378" checksum="58A84ACA9EA46C2E" modified="2018-04-25" version="1">MSDPSDVPARYTVLVKPQLADKDGHPEHGNPLRVVSVEATGSSGESGYPRFEGEGVQVEIDPLTRSVEAVTVDGEELPYGWVAEIAAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JKT9</accession>
    <name>A0A2M9JKT9_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">4-hydroxy-2-oxovalerate aldolase</fullName>
            <shortName evidence="7">HOA</shortName>
            <ecNumber evidence="7">4.1.3.39</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">4-hydroxy-2-keto-pentanoic acid aldolase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">4-hydroxy-2-oxopentanoate aldolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">dmpG</name>
        <name evidence="9" type="ORF">CG723_33810</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CB01635</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>(S)-4-hydroxy-2-oxohexanoate = propanal + pyruvate</text>
            <dbReference type="Rhea" id="RHEA:36003"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:17153"/>
            <dbReference type="ChEBI" id="CHEBI:73142"/>
            <dbReference type="EC" id="4.1.3.43"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="6">
            <dbReference type="Rhea" id="RHEA:36004"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>(S)-4-hydroxy-2-oxopentanoate = acetaldehyde + pyruvate</text>
            <dbReference type="Rhea" id="RHEA:22624"/>
            <dbReference type="ChEBI" id="CHEBI:15343"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:73143"/>
            <dbReference type="EC" id="4.1.3.39"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the 4-hydroxy-2-oxovalerate aldolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.3.39" evidence="7"/>
    <dbReference type="EMBL" id="NNBL01000020">
        <property type="protein sequence ID" value="PJN07472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN07472">
        <property type="protein sequence ID" value="PJN07472"/>
        <property type="gene ID" value="CG723_33810"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008701">
        <property type="term" value="F:4-hydroxy-2-oxovalerate aldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019439">
        <property type="term" value="P:aromatic compound catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07943">
        <property type="entry name" value="DRE_TIM_HOA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01656">
        <property type="entry name" value="HOA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017629">
        <property type="entry name" value="4OH_2_O-val_aldolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012425">
        <property type="entry name" value="DmpG_comm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035685">
        <property type="entry name" value="DRE_TIM_HOA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000891">
        <property type="entry name" value="PYR_CT"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07836">
        <property type="entry name" value="DmpG_comm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00682">
        <property type="entry name" value="HMGL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03217">
        <property type="entry name" value="4OH_2_O_val_ald"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50991">
        <property type="entry name" value="PYR_CT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0058">Aromatic hydrocarbons catabolism</keyword>
    <keyword evidence="5 7" id="KW-0456">Lyase</keyword>
    <keyword evidence="4 7" id="KW-0464">Manganese</keyword>
    <keyword evidence="2 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyruvate carboxyltransferase" evidence="8">
        <location>
            <begin position="6"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="7">
        <location>
            <begin position="14"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="7">
        <location>
            <position position="18"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="15"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="168"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="197"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="199"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="288"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="7">
        <location>
            <position position="14"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008944"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023518"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PJN07472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="342" mass="36190" checksum="2007B41CC3899AD6" modified="2018-04-25" version="1">MSAKSLYVQDVTLRDGMHAIRHRYTVEQAAAIAGALDAAGVAAIEISHGDGLAGSSVNYGVGAHTDWEWIEAVVGATKKAVPTTLLLPGIGTIQDLKQAHALGIRSVRVATHCTEADVAAQHIAAARELGMDVAGFLMMSHMSEPADLARQAKLMESYGAHCVYVTDSGGRLTMDGVRSRFRAYRDVLDPATELGIHAHHNLALGVANTVVAVEEGVTRVDASLAGQGAGAGNCPLEAFIAVADLQGWKHGCDLFPLMDAADDLVRPLQDREVRVDRETLSLGYAGVYSSFLRHAEAAATRYGLDTRTILVEVGRRGMVGGQEDMITDIALDLVGGRENASP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JKY6</accession>
    <name>A0A2M9JKY6_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Peptidase_S8 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CG723_32740</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CB01635</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the peptidase S8 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000019">
        <property type="protein sequence ID" value="PJN07540.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN07540">
        <property type="protein sequence ID" value="PJN07540"/>
        <property type="gene ID" value="CG723_32740"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000209">
        <property type="entry name" value="Peptidase_S8/S53_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023827">
        <property type="entry name" value="Peptidase_S8_Asp-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022398">
        <property type="entry name" value="Peptidase_S8_His-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023828">
        <property type="entry name" value="Peptidase_S8_Ser-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015500">
        <property type="entry name" value="Peptidase_S8_subtilisin-rel"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00082">
        <property type="entry name" value="Peptidase_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00723">
        <property type="entry name" value="SUBTILISIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="SSF52743"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00136">
        <property type="entry name" value="SUBTILASE_ASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00137">
        <property type="entry name" value="SUBTILASE_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00138">
        <property type="entry name" value="SUBTILASE_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 5" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0720">Serine protease</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014799561" description="Peptidase_S8 domain-containing protein" evidence="7">
        <location>
            <begin position="41"/>
            <end position="1132"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_S8" evidence="8">
        <location>
            <begin position="246"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="42"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="401"/>
            <end position="430"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PJN07540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="1132" mass="119469" checksum="0C88A0497DDC8C89" modified="2018-04-25" version="1">MRDMNSRWRPWVRRPRSRPAAATAALVALLAGLTVAPAAARDLTPDTGRSGAGAPGGATPARTPMVSRHQVTLVTGDRVTLETDTSGRQSVSVEPAKGREHIMFVKRQQGHDWTVIPADALPLLAAGRLDKALFNVSALVKGKYAERSSLPLIVQYTGDASSAKSRLTAAGADEVRPVSGTSFAALSESRRDAPAFWAGIAPATAGAKSFGAGVSRVWLDGHAKVQLDSTAPLIGAPHAWELGYKGDGVKVAVLDTGFDPNHPDLKGLVAESANFTGEPNTDDLNGHGTHVTSTIAGSGAASDGRYKGVAPGAQVLFGKVCTMDGNCDDSAIVEGLAWAAQHGAKVINLSLGDIDTPETDAIEAVVDTVTRDYGTLVVAAAGNNGSGSKVSSPASADRALAVGASEADDDRADFSSVGPRTGDSGLKPDTIAPGVNVVGAMAGGTNADDGYVAMSGTSMATPHVAGSAAILFQQHPDWTPEQVKRQLMHSATGAKEHGAYFQGAGRVDVARAVDQEVSAEPTGLDFGLVRWTDGKRPPVTKTITYRNPGAEPLTLHVTQHASTGRLDRPAPEGLFQLGDDTVTVPAHGTADVRFTVTPEATTAYVAYSGVVTAATADGKISVRVPFGMDLEQPSHDLRITLKGRSGAAPDYADLLVNSADGRTYEQELVGQGSTVLRLPNDTYSVTGFFFDGAFTEATVVGVPKAVMTTDQKETIDARTARPVTVSAPSRTARIASAEVGTISLGDQLLSVTMANAIGSDHIEGVYATPTARFKDSKFTYLVSTVWNELAADGGNPSSVYYLSRPVHGAIPADPGYRPRKSELATVNTTFAATAPGTTATRIVWMYVDNVRFGGQSMEGLPVPNRRVDYFSAAEGLRWQTAFDQNSFLDPSKTGQSYLSALHGYKAGAKVEERWNGGVQAVGFSPEGMNTFREGDDMWYAFQFAANGDLDLVGDTTTGMPTVELRRNGELVPHSWGLAQVPADATPADYRLTFAVDRDRAPSSVSTKLRAEWQFRSQTTATRQALPLYAVRMSPELDEWNRARAGRALDIPVLIQRTVGAAESPIRAVTVEVSYDEGRTWQSTAVKGSGTHRTVTVDSPRRAAGGSVSLRTYVKDAAGDSFKQTVIKAYLLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-09-29" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JLD0</accession>
    <name>A0A2M9JLD0_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Protein-export membrane protein SecF</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9 11" type="primary">secF</name>
        <name evidence="11" type="ORF">CG723_31880</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CB01635</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Forms a complex with SecD. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF. Other proteins may also be involved.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cell membrane</location>
            <topology evidence="9">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the SecD/SecF family. SecF subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000018">
        <property type="protein sequence ID" value="PJN07679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN07679">
        <property type="protein sequence ID" value="PJN07679"/>
        <property type="gene ID" value="CG723_31880"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015450">
        <property type="term" value="F:protein-transporting ATPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0065002">
        <property type="term" value="P:intracellular protein transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006605">
        <property type="term" value="P:protein targeting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043952">
        <property type="term" value="P:protein transport by the Sec complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01464_B">
        <property type="entry name" value="SecF_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022813">
        <property type="entry name" value="SecD/SecF_arch_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022645">
        <property type="entry name" value="SecD/SecF_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022646">
        <property type="entry name" value="SecD/SecF_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005665">
        <property type="entry name" value="SecF_bac"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30081">
        <property type="entry name" value="PTHR30081"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07549">
        <property type="entry name" value="Sec_GG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02355">
        <property type="entry name" value="SecD_SecF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01755">
        <property type="entry name" value="SECFTRNLCASE"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00916">
        <property type="entry name" value="2A0604s01"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00966">
        <property type="entry name" value="3a0501s07"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 9" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 9" id="KW-0811">Translocation</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="26"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="140"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="164"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="191"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="246"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="275"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="322"/>
            <end position="373"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PJN07679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="373" mass="39573" checksum="A7EB8FE9B8B0BBDF" modified="2018-04-25" version="1">MSKLGHLGARLIRGEVGYDFIGKRKIWYGVSILITITAIVGLAVRGLNMGIEFEGGAVFTTPKTSVSAGTAERSAEAASSHDAIVQELGTGGLRIQISGVDTAKSDQIKTQLSKDLNVPEAKINADLVGPSWGETIANKAWTGLIVFMILVVIYLAIAFEWRMAIAALVALIHDLTITVGIYALVGFEVTTGTIIGLLTILGYSLYDTVVVFDSLKEGTKDITKQTRFTYSEVANRSINGTLVRSINTTVVALLPVAGLLFIGGGFLGAGMLNDISLSLFVGLAAGAYSSIFIATPLVADLKERDPQIKALKKRVLAKRAAAAAKGESAEAPEPQDDDYDDPSDDEATTAVVGPRHQPASRNRGRGRPSGKRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JLK9</accession>
    <name>A0A2M9JLK9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_33405</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000019">
        <property type="protein sequence ID" value="PJN07657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN07657">
        <property type="protein sequence ID" value="PJN07657"/>
        <property type="gene ID" value="CG723_33405"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018721">
        <property type="entry name" value="DUF2252"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39441">
        <property type="entry name" value="PTHR39441"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10009">
        <property type="entry name" value="DUF2252"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN07657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="477" mass="51315" checksum="1BF052E15DE43682" modified="2018-04-25" version="1">MTELDTAVPAQREEPAARRLPAVEGFAALPSSGSPKQEGKALRDRVPRSAHAALTLHPARPDAVRAVEESNLGRIEELTPIRVGRMAATPFAFLRGSAGLMAHDLAQTPVTGVGAQICGDAHAANFGLYADARGGLVIDLNDFDETVHGPWEWDVKRLATSLVLAGRVAGADEDTCREAAHYAVGAYRRTMRLLARLPALDAWNAIADEELVSHTDAHDLVGTLERVSEKARNNTSGRFAAKSTELADDGTRRFVDAPPVLRRVPDEEASEVAASLGDYLQTLSEDRLPLLGRYAIQDVAFRVVGTGSVGTRSYVVLLLDHRGEALVLQVKEARPSALLPHLPAVGFDTPAAAHEGRRVVLGQKRMQVVSDILLGWTTVAGRPFQVRQFRNRKGSVDPAALAADQMDDYGRMTGALLARAHAHSADPRLIAGYCGKNEELDEAIAQFAVTYADRTEQDHAALVRAVREGRVGAEVGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JLV3</accession>
    <name>A0A2M9JLV3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CG723_31225</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CB01635</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">In the C-terminal section; belongs to the transposase 35 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000017">
        <property type="protein sequence ID" value="PJN07871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN07871">
        <property type="protein sequence ID" value="PJN07871"/>
        <property type="gene ID" value="CG723_31225"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032196">
        <property type="term" value="P:transposition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001959">
        <property type="entry name" value="Transposase_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010095">
        <property type="entry name" value="Transposase_IS605_OrfB_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01385">
        <property type="entry name" value="OrfB_IS605"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07282">
        <property type="entry name" value="OrfB_Zn_ribbon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01766">
        <property type="entry name" value="tspaseT_teng_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0815">Transposition</keyword>
    <feature type="domain" description="OrfB_IS605" evidence="6">
        <location>
            <begin position="177"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="domain" description="OrfB_Zn_ribbon" evidence="7">
        <location>
            <begin position="301"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="378"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="383"/>
            <end position="407"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF07282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PJN07871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="417" mass="46356" checksum="31843E5B7D767C8B" modified="2018-04-25" version="1">MKLTVQVKLLPTPVQAAALEETLRACNEAATWVSSVAFERDVKSNFALREHTYTAVKDRWRLGAQAAQHVIKKTCDAYTTLKANLTAGNLGKPSSKRYRRATEKPIAFRPEGAQPYDDRMLSWQYTQRTVSIWTLSGRIKEVAFTAAPEHLARLALCRKGESDLLFRDGMWFLTATCEVPEAELTTGVTEFLGVDLGIVNIATTSDGQIMAGRRLNRGRLRERTLRTKLQRKNTPSVKRRLKNRRRKEARRARDINHKIAKHVVAEAERTGRGIALEVLTGIRARVRLRKPQRATHSSWAFAQLADFIAYKARRAGVPVVHVDPAYTSRTCAQCGHIDKANRASQGRFVCRSCGVVAHADWNGSRNIRHRAEELWRCGAQSTAPDPPPNTGRGTGRKRSTTASGARCASLGLSVPGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JM04</accession>
    <name>A0A2M9JM04_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Aliphatic sulfonate ABC transporter substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CG723_31535</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000017">
        <property type="protein sequence ID" value="PJN07911.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN07911">
        <property type="protein sequence ID" value="PJN07911"/>
        <property type="gene ID" value="CG723_31535"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001638">
        <property type="entry name" value="Solute-binding_3/MltF_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015168">
        <property type="entry name" value="SsuA/THI5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09084">
        <property type="entry name" value="NMT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00062">
        <property type="entry name" value="PBPb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014650728" evidence="2">
        <location>
            <begin position="30"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="domain" description="PBPb" evidence="3">
        <location>
            <begin position="37"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PJN07911.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="323" mass="33093" checksum="AECEFBCA22719A38" modified="2018-04-25" version="1">MIRRLAAAALSLSALLTLTACGADSSADAAGSEDAVTLTIGDQAKTLQTIVAASGALKGADYKVKWAEFEGAAPLYQAVQAGAADTAYSADLPALQALSGGVKFKNVAALKNDGRHVGIVVRKGSGISRVKDLKGQKVVVSSAKGSISEYLLANVLRQNGLKYSDVKVQYLLPTDAQAAFSSGKLKAWATFGVYQAVGLGQGGRLLVDGADGRVSGYGFIGASDKALANSAKKAALSDFLRRLTTALTWTSTHQDAYADAIVERNGADASVAKTLASAAYSKVLPITSDVNGTVQGVADLMHGIGVLDPNVDVAKSADTSVLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JMI1</accession>
    <name>A0A2M9JMI1_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Formyltetrahydrofolate deformylase</fullName>
            <ecNumber evidence="3">3.5.1.10</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Formyl-FH(4) hydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3 6" type="primary">purU</name>
        <name evidence="6" type="ORF">CG723_30760</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CB01635</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the hydrolysis of 10-formyltetrahydrofolate (formyl-FH4) to formate and tetrahydrofolate (FH4).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>(6S)-10-formyltetrahydrofolate + H2O = (6S)-5,6,7,8-tetrahydrofolate + formate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19833"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="ChEBI" id="CHEBI:57454"/>
            <dbReference type="EC" id="3.5.1.10"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Purine metabolism; IMP biosynthesis via de novo pathway; formate from 10-formyl-5,6,7,8-tetrahydrofolate: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the PurU family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.10" evidence="3"/>
    <dbReference type="EMBL" id="NNBL01000016">
        <property type="protein sequence ID" value="PJN08064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08064">
        <property type="protein sequence ID" value="PJN08064"/>
        <property type="gene ID" value="CG723_30760"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00170"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008864">
        <property type="term" value="F:formyltetrahydrofolate deformylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016742">
        <property type="term" value="F:hydroxymethyl-, formyl- and related transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006730">
        <property type="term" value="P:one-carbon metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04875">
        <property type="entry name" value="ACT_F4HF-DF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd08648">
        <property type="entry name" value="FMT_core_Formyl-FH4-Hydrolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01927">
        <property type="entry name" value="PurU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002912">
        <property type="entry name" value="ACT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041729">
        <property type="entry name" value="Formyl-FH4-Hydrolase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002376">
        <property type="entry name" value="Formyl_transf_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036477">
        <property type="entry name" value="Formyl_transf_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004810">
        <property type="entry name" value="PurU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044074">
        <property type="entry name" value="PurU_ACT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42706">
        <property type="entry name" value="PTHR42706"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00551">
        <property type="entry name" value="Formyl_trans_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01575">
        <property type="entry name" value="FFH4HYDRLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53328">
        <property type="entry name" value="SSF53328"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="SSF55021"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00655">
        <property type="entry name" value="PurU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51671">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 3" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="3" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ACT" evidence="5">
        <location>
            <begin position="31"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PJN08064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="309" mass="33737" checksum="55DAD495F768ED69" modified="2018-04-25" version="1">MTDSPASAASPVPASPAPSPTGPATAPVEHVLTLDCPEAPGIVHAVSRFLVEHGSDIIDNQQFGDRRDGHFFMRVHFAATGGENTTQAMRDDFAAVAASFAMRWHIEPVSTRRRVLIMVSRYDHCLNDLLFRTRSGDLPIDVVAVVSNHRDHEALVAWHGVPFFHVPVTASTKPEAEAQLLELIDSFDVDLVVLARYMQVLSDGLCAQLPGRLINIHHSFLPSFKGAKPYHQAHDRGVKLVGATAHYVTADLDEGPIIAQEVISADHSHTPEDLAAIGRDAESAALARAVRWHCEGRVFVQGRRTVVLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JMV9</accession>
    <name>A0A2M9JMV9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CG723_29870</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000015">
        <property type="protein sequence ID" value="PJN08212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08212">
        <property type="protein sequence ID" value="PJN08212"/>
        <property type="gene ID" value="CG723_29870"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PJN08212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="50" mass="5405" checksum="78AD7B2BDEC15AFB" modified="2018-04-25" version="1">MRFEIMRLDDVDGTAVDSTVVDAASVNRIVQQAAAIGQRLYIRPAESPAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-09-29" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JNH4</accession>
    <name>A0A2M9JNH4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CG723_28990</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CB01635</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000014">
        <property type="protein sequence ID" value="PJN08416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08416">
        <property type="protein sequence ID" value="PJN08416"/>
        <property type="gene ID" value="CG723_28990"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="61"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="89"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="114"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="146"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="174"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="208"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="233"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="277"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="312"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="344"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="372"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="418"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="449"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="23"/>
            <end position="473"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PJN08416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="489" mass="49669" checksum="012FF3253A16109D" modified="2018-04-25" version="1">MSRVKAAHGPAAPGPGGARVAAVVGFLVFVELISGILQGMMPTLLPGLGADLEITAGDLNWVSSAQLLAAAISVPIFGRLGDLYGHRRLLRIAALCLAAGSVLVAWAPSFELLLLGRVLQGPLAALLPLEMGLVRDRLSPEGARSAIGLLVGALTFGASAGTVLAGLLSEVVTSVHGILWIPAAATALCVGIVFFLVPESRTRAGGTVDWAGAGLLSVGLAALLLAISQGPRWGWTGGGTLGLFAVAALVLVVWVLVELRVAHPVVDIRLTVKRTLLPVYGASFLLGGALFGSQTAASLFLSSPPERLGYGFGYGTLGIGWMMAPWGLMAFAGSATVPRLARAIGARAVLALSGAFMAAGYTALAFAHAEPWQFVVANLVLGFGMGLALSAMPALVLDASPADRTGIATGVYNTSKTLGGSVSGAVFAAILTAITFKGTEIPTESAYTTVWWCCAGVSLLVAAAAALVVRARQAPAETDAAPQQPAPVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JNP4</accession>
    <name>A0A2M9JNP4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CG723_28590</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000014">
        <property type="protein sequence ID" value="PJN08491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08491">
        <property type="protein sequence ID" value="PJN08491"/>
        <property type="gene ID" value="CG723_28590"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PJN08491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="279" mass="30013" checksum="4D48A223E31FE55E" modified="2018-04-25" version="1">MNRTPVAVRALARAALAARPVGLDETDAAAPLLRHHGHSYLVPVELFQDFAALLTDPRRPGGPYRTLSVGGRRWFGYRSTHYDTPALRSFHDHAQERAPRFGIRERLYQDSGRRQLELKVRGADGATVKHRTRLGEGDDPLDDTGRAFVTGVLRGTYGIGAPQELAARVVTEYRRATFVADGQRLTCDAGLVVRDAGEGRAVRADGGSVLVETKAGAPGRPTDADRLLARFGVAPVAFGKYCGGLAVLRPELAAGPWQEAVRTLFPGAVPAGEGDSVSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JNS2</accession>
    <name>A0A2M9JNS2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PIG-L domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_27420</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000013">
        <property type="protein sequence ID" value="PJN08514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08514">
        <property type="protein sequence ID" value="PJN08514"/>
        <property type="gene ID" value="CG723_27420"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016137">
        <property type="term" value="P:glycoside metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10320">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003737">
        <property type="entry name" value="GlcNAc_PI_deacetylase-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024078">
        <property type="entry name" value="LmbE-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12993">
        <property type="entry name" value="PTHR12993"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02585">
        <property type="entry name" value="PIG-L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102588">
        <property type="entry name" value="SSF102588"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN08514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="243" mass="26415" checksum="8D3DD1B6AE801EF4" modified="2018-04-25" version="1">MADTLLELPDDFSRVLAIVAHPDDIEFGAGPAVAQWTAQGREVAYLLVTRGEAGISDLEPARCGPVREAEQRKAAAELGVHEVDFLDHYHDGTIEYGPGLRRDLARAVRRHRPELIVTFNHHDTWASGAWNTPDHRAVGLAALDAVADAANRWIFPELLDEGLEPWRAGKVAIAGSPHATHAVAVDDDSRDRAVRSLAAHDRYLGSLSDDPPQERARFILGHLLAATAPRFGGRNGVAFQIVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JP69</accession>
    <name>A0A2M9JP69_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DoxX family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_26565</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000012">
        <property type="protein sequence ID" value="PJN08664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08664">
        <property type="protein sequence ID" value="PJN08664"/>
        <property type="gene ID" value="CG723_26565"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="95"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="122"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN08664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="150" mass="16586" checksum="13EB75042EDB9677" modified="2018-04-25" version="1">MDSIWLDGVEWLAVLRIGLGLWWLESWRHKDKKGWFERGTGIAWAADVAAKHRWNAVRSGFGAVVTPRPKVMAYIVVYAELALGLGLVAGLLTPVALIGGLLLNLLYLVLMIHDWAEQGQNAMMALISLVALFAMSWQAWSLDAAIGLFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JPB0</accession>
    <name>A0A2M9JPB0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CG723_26855</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000012">
        <property type="protein sequence ID" value="PJN08712.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08712">
        <property type="protein sequence ID" value="PJN08712"/>
        <property type="gene ID" value="CG723_26855"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PJN08712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="88" mass="9451" checksum="3964569383C87526" modified="2018-04-25" version="1">MLKGRGLFLSVERSDAVEVVYVCVDDGIPGGYPVGYVISSRTGTWAAYARVRPGRIFTTDEISSGLGSVEEAIRAVVAHARYEDVLTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JPP0</accession>
    <name>A0A2M9JPP0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_25415</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000011">
        <property type="protein sequence ID" value="PJN08842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08842">
        <property type="protein sequence ID" value="PJN08842"/>
        <property type="gene ID" value="CG723_25415"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046096">
        <property type="entry name" value="DUF6114"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19609">
        <property type="entry name" value="DUF6114"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="28"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="59"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="89"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="158"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN08842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="185" mass="18978" checksum="A630F389C69E27E2" modified="2018-04-25" version="1">MSAEAQAGLGDRLGQTRRSFRGWRGQRPFWGGLLTLLGGIPIMYFPYANLTLGSMTIRMSTTAGAGSLIIGVLLVVLGLTLWFQPMSRVFAGVAAILLALVSLVVSNFGGFVIGFLLALLGGALGISWGPSRAAKTETGGVKSADDADSPKGETAAFDAFGGASDDLSGTSPNGNDGTNGRHRAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-09-29" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JQ65</accession>
    <name>A0A2M9JQ65_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Transcriptional regulatory protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CG723_25345</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CB01635</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000011">
        <property type="protein sequence ID" value="PJN09010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN09010">
        <property type="protein sequence ID" value="PJN09010"/>
        <property type="gene ID" value="CG723_25345"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024187">
        <property type="entry name" value="Sig_transdc_resp-reg_cit/mal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45526">
        <property type="entry name" value="PTHR45526"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006171">
        <property type="entry name" value="RR_citrat_malat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0010">Activator</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0902">Two-component regulatory system</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="2"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="3">
        <location>
            <position position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRNR" id="PIRNR006171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PJN09010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="222" mass="23980" checksum="A97D6E5AAC2E26BB" modified="2018-04-25" version="1">MRVLIVEDDPVAADAHVLYVNRVPGFTAIGKAHTAAEAHRALERTQVDLLLLDLHLPDGHGLQLARSLRAAGHHTDVIAVTSARDLTVVREGVSLGVVQYVLKPFTFPTLRDRLVRYAEFRAAAGEAGGQDEVDRALATLRAPSPAALPKGLSAPTLERVTRTLRAAPEGLTAAAAAESVGISRITARRYLEHLVESGRAARSPQYGQVGRPELHYRWLTTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JQ90</accession>
    <name>A0A2M9JQ90_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DUF397 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_24210</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000010">
        <property type="protein sequence ID" value="PJN09041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN09041">
        <property type="protein sequence ID" value="PJN09041"/>
        <property type="gene ID" value="CG723_24210"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007278">
        <property type="entry name" value="DUF397"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04149">
        <property type="entry name" value="DUF397"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF397" evidence="2">
        <location>
            <begin position="6"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN09041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="74" mass="8195" checksum="66E0F5F4BF7C609B" modified="2018-04-25" version="1">MSDLRWERAAPEGADGPGPWIEIAFGPDDLVHLRETSAPETVVTTTQRKWDAFVLGVQAGEFDHFVEDADQQSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-05-25" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JQA7</accession>
    <name>A0A2M9JQA7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DNA-binding response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CG723_24345</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000010">
        <property type="protein sequence ID" value="PJN09063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN09063">
        <property type="protein sequence ID" value="PJN09063"/>
        <property type="gene ID" value="CG723_24345"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00383">
        <property type="entry name" value="trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="3">
        <location>
            <begin position="12"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="domain" description="OmpR/PhoB-type" evidence="4">
        <location>
            <begin position="142"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="2">
        <location>
            <begin position="142"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PJN09063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="244" mass="26743" checksum="0401EB7ED82CC58A" modified="2018-04-25" version="1">MSPAEGDREPQRILIVDDEPAVREALQRSLAFEGYGTEVAVDGADALGKAAAYQPDLVVLDIQMPRMDGLTAARRLRAGGSRTPILMLTARDTVGDRVTGLDAGADDYLVKPFELDELFARVRALLRRSAYASAAGPADDAGDVLSFADLRMDLATREVTRGARTVELTRTEFTLLEMFLAHPRQVLTREQILKAVWGFDFEPSSNSLDVYVMYLRRKTEAGGEPRLVHTVRGVGYVLRSGGSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JQB3</accession>
    <name>A0A2M9JQB3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_24380</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000010">
        <property type="protein sequence ID" value="PJN09069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN09069">
        <property type="protein sequence ID" value="PJN09069"/>
        <property type="gene ID" value="CG723_24380"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="251"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="273"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="303"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="329"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="354"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="378"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="404"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN09069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="430" mass="43403" checksum="49AE40D290CF0B5F" modified="2018-04-25" version="1">MSNEPYEDEYGQQQPPQQTQHWQGQTWDTQAQSTYPPPQGSEPGQAAYGQAEYGQAAYGQGPVSQTGGEQHAYGDQQAYGGEQRAYGDQQAYGGEQHAYGGDQQSYGYGQVPYGQGPAVQTPGGQTPPPAHAAYGQAPQGPGADQQTQVFGTVAAAQPLPVAEPEAAGYGPATVTGNARVTDAQRARAEGRSPIIEPGMQPAALTALLGLLLAGGAAVGQYALLVPLVLLQAVTAAGWFRLNGMWPARQGIALAFAGGLAADAALLVTGREHAPAAILGTLGVWVLLTLVLQLRSHAAPDERMYGLMATVASAALAIVATGHLAADPDAVTVGAVAVAVAVLARALPLPTPASVAVALLAAAGAGIAAGGLTDMGSKGALLGLGAGVCALIGHRVASYDYPSRFVHMTAGVALPLAAAAPAVYLLGRVVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-09-29" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JQM1</accession>
    <name>A0A2M9JQM1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Carbohydrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CG723_24915</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000010">
        <property type="protein sequence ID" value="PJN09155.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN09155">
        <property type="protein sequence ID" value="PJN09155"/>
        <property type="gene ID" value="CG723_24915"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005084">
        <property type="entry name" value="CMB_fam6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="SSF49785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51175">
        <property type="entry name" value="CBM6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="122"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="domain" description="CBM6" evidence="3">
        <location>
            <begin position="183"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="149"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="55"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="158"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PJN09155.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="322" mass="32680" checksum="EEEFAB6E97B174BB" modified="2018-04-25" version="1">MAPADNGEGTPADDDPFGYLYADGQAAGATPPSGGGGYGYPGPRSYHQVRPVGERQYGQQPQQAPTAAYGQAPPQQQPQGYGQPNAHYSAPETLPGGAPTTVTPTQHGGGGGRGRGPNTKGLLIGALAVVAAVVIGIGVAVLGGDSNDDAKGGDAGGQPSGGSQSVQPSETASKKADEPVDLPKTDAKALKLEGGTATASDVKGAKADGGTYVAGFNQVGAKLTWTVNGIPKDGAYSLRVNYGVPGKHADATITVNGKVQTRPLNMDNFSGAKEGDWEKGWTTTWSVVQLSKGTNAITISCEQGNQCDANFDQMWLVKGTKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JQS9</accession>
    <name>A0A2M9JQS9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Exopolyphosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CG723_25275</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000010">
        <property type="protein sequence ID" value="PJN09221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN09221">
        <property type="protein sequence ID" value="PJN09221"/>
        <property type="gene ID" value="CG723_25275"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010839">
        <property type="entry name" value="AtuA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07287">
        <property type="entry name" value="AtuA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PJN09221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="588" mass="62044" checksum="5C7BE6F8D93A1E16" modified="2018-04-25" version="1">MTEDVLRIGNASGFYGDRFDALREMLEDGPLDVLTGDYLAELTMLILGRDRLKDPARGYARTFLRQLEETLGPALDRGVRIVANAGGLNPAGLADAVRALADRLGLHARVAHVEGDDLSPGGRFPGALTANAYLGGAGIAACLAAGADIVVTGRVTDAALVTGPAAWRFGWEQDAYDRLAGAVVAGHILECGTQATGGNYSRFAGRARDLRRPGFPLAELHADGSCVITKHPGTGGLVTVGTVTEQLLYETGGARYAGPDVTARLDTVRLTQEAPDRVRVDGVRGEAPPPTLKVGLNRLGGFRNEVVFVLTGLDIEAKASLVREQMDEAFDRAKSRPAQVTWELARTDRADADTEETASALLRLVVRDGDADAVGRTLSSAAIELALGSYPGFHVTAPPGKGAPYGVFEAAYVDRGEVEQVAVLPDGERKLITYDGPVRALTDVEEPPLPAPLPPGPTRRAPLGLVAGARSGDKGGDANVGVWVDGGEGSDGDWAGAGAGAGAGAGDQDEAWRWLVHEMTADRFQNLIAESRQLTVVRHVLPNLRALNFTVTGLLGQGVASQHRFDPQAKGLGEWLRSRHLDIPEVLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JQU1</accession>
    <name>A0A2M9JQU1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">1-phosphofructokinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CG723_24920</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CB01635</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the carbohydrate kinase PfkB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000010">
        <property type="protein sequence ID" value="PJN09246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN09246">
        <property type="protein sequence ID" value="PJN09246"/>
        <property type="gene ID" value="CG723_24920"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016773">
        <property type="term" value="F:phosphotransferase activity, alcohol group as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01164">
        <property type="entry name" value="FruK_PfkB_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002173">
        <property type="entry name" value="Carboh/pur_kinase_PfkB_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011611">
        <property type="entry name" value="PfkB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017583">
        <property type="entry name" value="Tagatose/fructose_Pkinase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00294">
        <property type="entry name" value="PfkB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000535">
        <property type="entry name" value="1PFK/6PFK/LacC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="SSF53613"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03168">
        <property type="entry name" value="1-PFK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00583">
        <property type="entry name" value="PFKB_KINASES_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00584">
        <property type="entry name" value="PFKB_KINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PfkB" evidence="5">
        <location>
            <begin position="13"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR000535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PJN09246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="310" mass="31819" checksum="2508BEDFA7CB377B" modified="2018-04-25" version="1">MILTVTLNAALDITYDVPALHPHASHRVTKVTERPGGKGLNVARVLAALGHDVTVTGFAGGGTGRALREQLLDSPGIRDALVPVSGATRRTIAVVDGASGDTTQLNEPGPLVAPAEWSAFTEAYEELLTSASAVALCGSLPPGVPVGAYAQLVRAARAASVPVLLDSSGEPLRRGLAARPDVIKPNSDELAELTGSHEPLRATRDARRRGAHSVVASLGPEGLLAVTPDGSWRAPAPDRVKGNPTGAGDSAVAGLLSGYVEDLPWPDRLARAVALSAATVLAPVAGEFDRAAYEELLGRVSVTQQTTTAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JQV1</accession>
    <name>A0A2M9JQV1_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Pectate_lyase_3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_24595</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000010">
        <property type="protein sequence ID" value="PJN09241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN09241">
        <property type="protein sequence ID" value="PJN09241"/>
        <property type="gene ID" value="CG723_24595"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024535">
        <property type="entry name" value="Pectate_lyase_SF_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12708">
        <property type="entry name" value="Pectate_lyase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="SSF51126"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pectate_lyase_3" evidence="1">
        <location>
            <begin position="60"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN09241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="539" mass="59003" checksum="92C04F355A70D638" modified="2018-04-25" version="1">MTATGTGARAATARPGEVPPIWREFTRTPYTHPQIPYVGRAGYRVGRHGFARPRVVADVVRDYGARPDGSADAAPAINRALADAGRAGGGTVHLPPGTYRIDDLIRIGHCGVVLRGAGSTRTKLYATRSLTELIGVYGSRYGGDKSSWSWAGGLVWLCPEDRFRTLTDAIRAKAWPFEGWTGNKRDEWDTLTAVEPATRGSWSVTVADATRLSRGDLVLLRLVDDPGHTLLEHMAGGGPGPEAYFWDDKTKLTSYVPYEWPVRIESVHGRRVTFERPLPLDVRPEWDPRLTTHAGALTGSGVEALTLEAVETPQSQHLLDKGYNGVAFQCAYDCWADDVTVRHVDNGFGLVAASACTLRRTRVAGRGSHHPYFCREGSHDNLVESFTIEQRTVPAPAGTQLHGINVEGLSSYNVWSRGEMEMGTFDSHRGMPFANVRTDITVNNDGRHGGDASAGPLFGARFTHWNIRVTNQRAGLMRIDGLAPYSATVAVNTVREFDQIDVPDFTGDLHARLELYGDGVSDTVRPRNLYDAQRSSVGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JRF5</accession>
    <name>A0A2M9JRF5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">NUDIX hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CG723_21910</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CB01635</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the Nudix hydrolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000008">
        <property type="protein sequence ID" value="PJN09438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN09438">
        <property type="protein sequence ID" value="PJN09438"/>
        <property type="gene ID" value="CG723_21910"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020476">
        <property type="entry name" value="Nudix_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020084">
        <property type="entry name" value="NUDIX_hydrolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00502">
        <property type="entry name" value="NUDIXFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="SSF55811"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00893">
        <property type="entry name" value="NUDIX_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="5">
        <location>
            <begin position="29"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="13"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003476"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PJN09438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="171" mass="18700" checksum="CA674FD3F2DB186D" modified="2018-04-25" version="1">MRASPAVSSPLASPPPERSSVSANREPAQQHSVSVAGVAVREDGRVLVIRRADNGRWEPPGGVLERDEAIEEGVRREVYEETGIKVHVERLTGVYKNMTLGVVALVFRCSPAGGHERLSDESTAVTWLALDEVMTRMSEAYSVRIADALTDDLAPHIRTHDGRNLTVPDCY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JRX9</accession>
    <name>A0A2M9JRX9_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 5">Beta-galactosidase</fullName>
            <shortName evidence="5">Beta-gal</shortName>
            <ecNumber evidence="3 5">3.2.1.23</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CG723_22670</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">CB01635</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 5">
            <text>Hydrolysis of terminal non-reducing beta-D-galactose residues in beta-D-galactosides.</text>
            <dbReference type="EC" id="3.2.1.23"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the glycosyl hydrolase 42 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.23" evidence="3 5"/>
    <dbReference type="EMBL" id="NNBL01000008">
        <property type="protein sequence ID" value="PJN09547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN09547">
        <property type="protein sequence ID" value="PJN09547"/>
        <property type="gene ID" value="CG723_22670"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009341">
        <property type="term" value="C:beta-galactosidase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004565">
        <property type="term" value="F:beta-galactosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006012">
        <property type="term" value="P:galactose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013739">
        <property type="entry name" value="Beta_galactosidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013738">
        <property type="entry name" value="Beta_galactosidase_Trimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003476">
        <property type="entry name" value="Glyco_hydro_42"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013529">
        <property type="entry name" value="Glyco_hydro_42_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36447">
        <property type="entry name" value="PTHR36447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02449">
        <property type="entry name" value="Glyco_hydro_42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08533">
        <property type="entry name" value="Glyco_hydro_42C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08532">
        <property type="entry name" value="Glyco_hydro_42M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001084">
        <property type="entry name" value="B-galactosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Glyco_hydro_42" evidence="9">
        <location>
            <begin position="15"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_hydro_42M" evidence="10">
        <location>
            <begin position="399"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_hydro_42C" evidence="11">
        <location>
            <begin position="614"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="6">
        <location>
            <position position="151"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="6">
        <location>
            <position position="309"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="112"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="116"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="150"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="156"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="158"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="161"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001412"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR001084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR001084-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR001084-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR001084-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF08532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF08533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PJN09547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="675" mass="74567" checksum="C72F8F5EBAFDBAAF" modified="2018-04-25" version="1">MNGVPATPAIPYGGDYNPEQWPEEVWDADHRLFGKAGIDTLTVGVFTWSLLQPAPDTYDFTVLDRIVDRAAAEGRRIVLATGTAALPPWLAKAHPEVNRTDFEGRRHGYGQRHNFCPSSPAYRRLSTTLAGRIAERYADHPALLAWHINNEYGGACYCDLCAEAFRGWLREKYGSLDALNDAWWTTFWSHRYTDWSEIEPPSALTEHWRGPDHTAFQGITLDYHRFTTDALLGCFVAEKEAVRAHSPRTPVTTNFMGMYRPLDYHRWAPHLDFASWDSYPPLGAPPTWPALAHDLMRGLRGGAPFWLMEQTPSTTACRDVNPLRRPGELRLASWQAVAHGADAVLYFQMRASRGACEKYHGAVIGHAGRDDTRVFREVATLGRELADAGGVTLGARTPARTALLFDWDSWWALEMSDGPSRLVRYQDVVHSYYRAARTAGADVDVVPVTADLSAYDVVLAPLLHLVKGDLPARLEAVAVRGGTVVTTYLSGRGDEHDRAFLTDVPGPLGPLMGVRVDEWDSRPAEVTNPVDFGDLRSPARLVFELVVPQGAEPVATYTTDFYAGTPAVTRNRFGERGGEGWYVATQLDDAGTDRVVRQVLARHGLVGPYAEMAGVETATRVAPDGTRLRFLLNHNSSEAELTVHESATDLLTGKAYAPGEPLTLDPLGVCVLRLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JS95</accession>
    <name>A0A2M9JS95_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DNA mismatch repair protein MutT</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CG723_21325</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CB01635</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the Nudix hydrolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000007">
        <property type="protein sequence ID" value="PJN09746.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN09746">
        <property type="protein sequence ID" value="PJN09746"/>
        <property type="gene ID" value="CG723_21325"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020476">
        <property type="entry name" value="Nudix_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020084">
        <property type="entry name" value="NUDIX_hydrolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00502">
        <property type="entry name" value="NUDIXFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="SSF55811"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00893">
        <property type="entry name" value="NUDIX_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="4">
        <location>
            <begin position="11"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003476"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PJN09746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="173" mass="19360" checksum="D940655AC9758025" modified="2018-04-25" version="1">MRAEPPGAGRELRKVARVVLLDPDDRILLLHGHEPGDTADDWWFTPGGGLEGDETREQAALRELAEETGITDVELGPVLWRRTCSFPFDGRRWDQDEWYFLARTTAAVAGAEIAGAGLTELERRSVAGARWWTCRELTEAHETVYPTRLAGLLERLLDEGPPSRPEVLDTEIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JSK0</accession>
    <name>A0A2M9JSK0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Thiamine ABC transporter substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CG723_21395</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000007">
        <property type="protein sequence ID" value="PJN09854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN09854">
        <property type="protein sequence ID" value="PJN09854"/>
        <property type="gene ID" value="CG723_21395"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030975">
        <property type="term" value="F:thiamine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015888">
        <property type="term" value="P:thiamine transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd13545">
        <property type="entry name" value="PBP2_TbpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005948">
        <property type="entry name" value="ThiB-like"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01254">
        <property type="entry name" value="sfuA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PJN09854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="350" mass="37520" checksum="6837FDD5303E7233" modified="2018-04-25" version="1">MAAGLGLVALSACGGSGSGKDSAESKTVTLVSHDSWAVSKSVLKDFEKRSGYKVTVLKDGDAGEAVNKAILSKDNPQGDVLFGVDNTLLSRALDNGLFQPYEAKGLDQVRAEYQLDGDKHRVTPIDTGDICVNYDKKYFADHKLTPPASFDDLAKPAYKNLLVTENVSTSSPGLGFLLGSAAQYGDEGWQGYWKKLKANGVKVVDGWEQAYNEEFSGSAGGRKAGGDRPLVVSYASSPPAEAIYSDPQPKTAPTGVATGTCFRQTEFAGLLSNAKNEKGGKALLDFLIAKEFQQDMPLNMFVDPVTKDAALPADYAKYDIKVDAPKTMAPKKIADNRDAWVKSWTSLVLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JSL7</accession>
    <name>A0A2M9JSL7_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Flavin-dependent thymidylate synthase</fullName>
            <shortName evidence="6">FDTS</shortName>
            <ecNumber evidence="6">2.1.1.148</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">FAD-dependent thymidylate synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Thymidylate synthase ThyX</fullName>
            <shortName evidence="6">TS</shortName>
            <shortName evidence="6">TSase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">thyX</name>
        <name evidence="7" type="ORF">CG723_21890</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CB01635</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + dUMP + H(+) + NADPH = (6S)-5,6,7,8-tetrahydrofolate + dTMP + NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:29043"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15636"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:63528"/>
            <dbReference type="ChEBI" id="CHEBI:246422"/>
            <dbReference type="EC" id="2.1.1.148"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="6">Binds 4 FAD per tetramer. Each FAD binding site is formed by three monomers.</text>
    </comment>
    <comment type="pathway">
        <text evidence="6">Pyrimidine metabolism; dTTP biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the thymidylate synthase ThyX family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.148" evidence="6"/>
    <dbReference type="EMBL" id="NNBL01000007">
        <property type="protein sequence ID" value="PJN09843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN09843">
        <property type="protein sequence ID" value="PJN09843"/>
        <property type="gene ID" value="CG723_21890"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00575"/>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050797">
        <property type="term" value="F:thymidylate synthase (FAD) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006231">
        <property type="term" value="P:dTMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006235">
        <property type="term" value="P:dTTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01408">
        <property type="entry name" value="ThyX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003669">
        <property type="entry name" value="Thymidylate_synthase_ThyX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036098">
        <property type="entry name" value="Thymidylate_synthase_ThyX_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34934">
        <property type="entry name" value="PTHR34934"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02511">
        <property type="entry name" value="Thy1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69796">
        <property type="entry name" value="SSF69796"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02170">
        <property type="entry name" value="thyX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51331">
        <property type="entry name" value="THYX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0274">FAD</keyword>
    <keyword evidence="2 6" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="1 6" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5 6" id="KW-0521">NADP</keyword>
    <keyword evidence="3 6" id="KW-0545">Nucleotide biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="active site" description="Involved in ionization of N3 of dUMP, leading to its activation" evidence="6">
        <location>
            <position position="200"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="69"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <note>ligand shared between neighboring subunits</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="89"/>
            <end position="92"/>
        </location>
        <ligand>
            <name>dUMP</name>
            <dbReference type="ChEBI" id="CHEBI:246422"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="92"/>
            <end position="94"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="101"/>
            <end position="105"/>
        </location>
        <ligand>
            <name>dUMP</name>
            <dbReference type="ChEBI" id="CHEBI:246422"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="101"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <note>ligand shared between neighboring subunits</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="173"/>
        </location>
        <ligand>
            <name>dUMP</name>
            <dbReference type="ChEBI" id="CHEBI:246422"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="189"/>
            <end position="191"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <note>ligand shared between neighboring subunits</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="195"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="200"/>
        </location>
        <ligand>
            <name>dUMP</name>
            <dbReference type="ChEBI" id="CHEBI:246422"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PJN09843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="246" mass="27960" checksum="FA63335D17A0D128" modified="2018-04-25" version="1">MTETPADDLKPTFRGDVTVELVKHTASDTDVLFAARVSTAGEQSLDELTKDPERSKGLINFLMRDRHGSPFEHNSMTFFINAPIFVFREFMRHRAGWSYNEESGRYRELQPVFYVPEASRKLVQQGRPGKYQFVEGTQGQQELTGRVMEDSYRQAYEAYQEMLAAGVAREVARSVLPVGLFSSMYATCNARSLMHFLGLRTQHELAKVPSFPQREIEMVGEKMEAEWAKLMPLTYAAFNGNGRVAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-09-29" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JSW8</accession>
    <name>A0A2M9JSW8_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NlpC/P60 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CG723_19870</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CB01635</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C40 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000006">
        <property type="protein sequence ID" value="PJN09986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN09986">
        <property type="protein sequence ID" value="PJN09986"/>
        <property type="gene ID" value="CG723_19870"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000064">
        <property type="entry name" value="NLP_P60_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00877">
        <property type="entry name" value="NLPC_P60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="SSF54001"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51935">
        <property type="entry name" value="NLPC_P60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NlpC/P60" evidence="4">
        <location>
            <begin position="259"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="216"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="72"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="174"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PJN09986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="374" mass="39452" checksum="4AB0749107EA3F09" modified="2018-04-25" version="1">MRAAAGRVSSTYRKDVPLVSAAHRKPRQRSLTGPTARTAATLALASAATATALDGAAHADPRLTPSQVKAKVDQLYQEAEKATEKYNGAKEKADKAEKKLGSLRDEAARRTDRLNTQREALGSAAAAQYRTGALDPAVQLVLSSDPAQYLDNAALADRLGTRQASAVGRVQRELRQIDQLRSEADGRLAELRKRQGELKKQKKTVTGKLAEAKRLLDQLPADERTGVGAGAGDSGAAGRASRSDSSREVPSGALPKAPDSRTAAAIAYAYSALGSPYVWGATGPNAFDCSGLTQAAYRSAGISLPRTTYSQINAGPRIPRSQLQPGDLVFFYSGISHVGLYIGNGKMIHAPNPSAPVRIAPIDEMPFAGATRVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-05-25" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JT22</accession>
    <name>A0A2M9JT22_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5">30S ribosomal protein S13</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">rpsM</name>
        <name evidence="8" type="ORF">CG723_20200</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CB01635</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits; these bridges are implicated in subunit movement. Contacts the tRNAs in the A and P-sites.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Part of the 30S ribosomal subunit. Forms a loose heterodimer with protein S19. Forms two bridges to the 50S subunit in the 70S ribosome.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5 6">Belongs to the universal ribosomal protein uS13 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000006">
        <property type="protein sequence ID" value="PJN10041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN10041">
        <property type="protein sequence ID" value="PJN10041"/>
        <property type="gene ID" value="CG723_20200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.910.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01315">
        <property type="entry name" value="Ribosomal_S13_S18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027437">
        <property type="entry name" value="30s_Rbsml_prot_S13_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001892">
        <property type="entry name" value="Ribosomal_S13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010979">
        <property type="entry name" value="Ribosomal_S13-like_H2TH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019980">
        <property type="entry name" value="Ribosomal_S13_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018269">
        <property type="entry name" value="Ribosomal_S13_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10871:SF1">
        <property type="entry name" value="PTHR10871:SF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00416">
        <property type="entry name" value="Ribosomal_S13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002134">
        <property type="entry name" value="Ribosomal_S13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46946">
        <property type="entry name" value="SSF46946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03631">
        <property type="entry name" value="uS13_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00646">
        <property type="entry name" value="RIBOSOMAL_S13_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50159">
        <property type="entry name" value="RIBOSOMAL_S13_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 5 6" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0699">rRNA-binding</keyword>
    <keyword evidence="5" id="KW-0820">tRNA-binding</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="94"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00029533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003830"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PJN10041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="126" mass="14394" checksum="475401EB67460797" modified="2018-04-25" version="1">MARLEGVDLPRDKRVEVALTYVFGIGRTLSQQTLDATGVDRNIRVRDLSEEDLIKIREYVDANIQTEGDLRREIQADIRRKVEIGCYQGLRHRRGLPVRGQRTSTNARTRKGPRRAIAGKKKPGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-06-02" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JT32</accession>
    <name>A0A2M9JT32_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 5">50S ribosomal protein L6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">rplF</name>
        <name evidence="7" type="ORF">CG723_20250</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CB01635</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3 5">This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Part of the 50S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 4">Belongs to the universal ribosomal protein uL6 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000006">
        <property type="protein sequence ID" value="PJN10051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN10051">
        <property type="protein sequence ID" value="PJN10051"/>
        <property type="gene ID" value="CG723_20250"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.930.12">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01365_B">
        <property type="entry name" value="Ribosomal_L6_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000702">
        <property type="entry name" value="Ribosomal_L6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020040">
        <property type="entry name" value="Ribosomal_L6_a/b-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036789">
        <property type="entry name" value="Ribosomal_L6_a/b-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019906">
        <property type="entry name" value="Ribosomal_L6_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002358">
        <property type="entry name" value="Ribosomal_L6_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11655">
        <property type="entry name" value="PTHR11655"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11655:SF14">
        <property type="entry name" value="PTHR11655:SF14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00347">
        <property type="entry name" value="Ribosomal_L6"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002162">
        <property type="entry name" value="Ribosomal_L6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00059">
        <property type="entry name" value="RIBOSOMALL6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56053">
        <property type="entry name" value="SSF56053"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03654">
        <property type="entry name" value="L6_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00525">
        <property type="entry name" value="RIBOSOMAL_L6_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="1 3 4" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3 5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 5" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="Ribosomal_L6" evidence="6">
        <location>
            <begin position="11"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="domain" description="Ribosomal_L6" evidence="6">
        <location>
            <begin position="92"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PJN10051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="179" mass="19218" checksum="D84E958D576D91A8" modified="2018-04-25" version="1">MSRIGKLPITVPAGVDVTIDGRTVSVKGPKGSLSHTIVAPIVITKDEDGVLNVARPNDERQNKALHGLSRTLVANMITGVTQGYVKKLEISGVGYRVLAKGSNLEFSLGYSHSIVIEAPEGISFKVESPTKFSVEGIDKQKVGEVAANIRKLRKPDPYKAKGVKYEGEVIRRKVGKAGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JT76</accession>
    <name>A0A2M9JT76_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">50S ribosomal protein L30</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">rpmD</name>
        <name evidence="7" type="ORF">CG723_20235</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CB01635</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2 5">Part of the 50S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the universal ribosomal protein uL30 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000006">
        <property type="protein sequence ID" value="PJN10048.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_041985698.1">
        <property type="nucleotide sequence ID" value="NZ_NNBL01000006.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN10048">
        <property type="protein sequence ID" value="PJN10048"/>
        <property type="gene ID" value="CG723_20235"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015934">
        <property type="term" value="C:large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01658">
        <property type="entry name" value="Ribosomal_L30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1390.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01371_B">
        <property type="entry name" value="Ribosomal_L30_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036919">
        <property type="entry name" value="L30_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005996">
        <property type="entry name" value="Ribosomal_L30_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016082">
        <property type="entry name" value="Ribosomal_L30_ferredoxin-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15892">
        <property type="entry name" value="PTHR15892"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00327">
        <property type="entry name" value="Ribosomal_L30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002211">
        <property type="entry name" value="Ribosomal_L30_bac-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55129">
        <property type="entry name" value="SSF55129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01308">
        <property type="entry name" value="rpmD_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 5 7" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Ribosomal_L30" evidence="6">
        <location>
            <begin position="4"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00327"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PJN10048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="60" mass="6951" checksum="F27CEBAB74C96FEE" modified="2018-04-25" version="1">MARLKITQTKSYIGSKQNHRDTLRSLGLKRLNDVVVKEDRPEFRGMANTVRHLVTVEEVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JTA4</accession>
    <name>A0A2M9JTA4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CG723_20655</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000006">
        <property type="protein sequence ID" value="PJN10115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN10115">
        <property type="protein sequence ID" value="PJN10115"/>
        <property type="gene ID" value="CG723_20655"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PJN10115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="75" mass="8514" checksum="371894C0B38FC077" modified="2018-04-25" version="1">MNTSYLDDIARRIAYATEQFTPSHRPNARQKADAAAILRDMVQATETHGLSFADFDGIADFPRMAIQLVQHRDQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JTC4</accession>
    <name>A0A2M9JTC4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Cell division protein FtsK</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CG723_20675</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000006">
        <property type="protein sequence ID" value="PJN10119.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN10119">
        <property type="protein sequence ID" value="PJN10119"/>
        <property type="gene ID" value="CG723_20675"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002543">
        <property type="entry name" value="FtsK_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50901">
        <property type="entry name" value="FTSK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="5" id="KW-0132">Cell division</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="179"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="domain" description="FtsK" evidence="4">
        <location>
            <begin position="358"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="17"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="374"/>
            <end position="381"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PJN10119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="730" mass="79875" checksum="7E15971A14B6B7D7" modified="2018-04-25" version="1">MTEMNLSGPPAEESADVLPFRLKKQDPAPDEVKPGEWEAELPDTDDPEADELTEGAQVDLPREAYPPSVSEWMEAKDKARLPVLPDWVKLPDQRTAVRKWAVRHYSTMVGYHAVRLPCIYAPKVLAYSPRGAWRWSTAIGRWVFDSEGKALRLAAVAAEDAGEYLALSRQRNDRVKMRGVVATIAGFIGLAAALTVYVMAPSWLLLLSVAALTTTLGAVGAPADRPLIDRAKVTFRKRKLSSDIIIRAHEAAKLTIKDQSISFPRPIGRDGDGWRVVVDLPYGLHFKDALNAHARLASGMDIAPTQLFLDIDETSNRRVSYWIADRDPLAVPSGKSPLLGATRVDFWKPFPWGVDERGNPVMATMLWLSLLVGAVPRQGKTFSARTIALAAALDPYVRLYVFDGKASPDWRAFAKVAHRIGFGIVPKNGIDPVGHLLSSLRELKADVEDRYHRLSELPLHICPEGKLTPEISRDKKLNMPLTLFVVDEVQEYLQHPEHGKEILALLVYLARVAPAVGVSVMTSTQKPDDKACPSELRDQHQARFALRVGAYQVSDTILGAGSYSEGLDASKLLKSHKGVGLLKGMSDDSGIVRTYLADGQDAERILTRAAALREAEGTLSGDAAGEAPAPEASATILDDVAQVLGKGETKVWSETIVDRLADLRPDVYGAWAELEAKPKAEALTAALKPYGVATEQIGRRIDGKPVNKRGIKREDLAAAITQRNEKRDAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JU47</accession>
    <name>A0A2M9JU47_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CG723_18150</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000005">
        <property type="protein sequence ID" value="PJN10307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN10307">
        <property type="protein sequence ID" value="PJN10307"/>
        <property type="gene ID" value="CG723_18150"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PJN10307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="96" mass="10296" checksum="834E71D144736344" modified="2018-04-25" version="1">MNSSATVLPTPDRDADADFLLPLPDPEQRLDIVPPAPSLLTPRDRHRLSLNATLTTAGIPPHPDDMEAIDALSALDDTVALAVQRWLISRPAALLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JU70</accession>
    <name>A0A2M9JU70_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_18815</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000005">
        <property type="protein sequence ID" value="PJN10413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN10413">
        <property type="protein sequence ID" value="PJN10413"/>
        <property type="gene ID" value="CG723_18815"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014650733" evidence="1">
        <location>
            <begin position="27"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN10413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="251" mass="25915" checksum="21FD4069DC87B340" modified="2018-04-25" version="1">MNPLRLATAAGAAVLLTLGAAGESWASTPTVRWTTGAPTPVTELTLPMSFESAPDASGIYFAYYTTLESGTRPYAGFQPKPAVDGKPTLQAIFSSFNANATTTDSHCKYGADGGAGVSCAVQFPYTKGTMYAVKLSRVSDDGTTQLMNGEVVNTETGADVAHIGSFRLPVASGRFKSADQGFIEPYLTAGCSQQVTVTYGRPVGTEGGNKYTGSLPTVTDPASGSCLSSTSSDTPVGRKVTVTGDQFTAGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JUA8</accession>
    <name>A0A2M9JUA8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_18060</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000005">
        <property type="protein sequence ID" value="PJN10486.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN10486">
        <property type="protein sequence ID" value="PJN10486"/>
        <property type="gene ID" value="CG723_18060"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014870533" evidence="1">
        <location>
            <begin position="27"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN10486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="119" mass="12800" checksum="EA27024B695EA6FE" modified="2018-04-25" version="1">MRRRSTVAASLAAFALALTLPASAQAATGDFSYKIVGLDGQTQSVTLHDLPSRQCVTLPEVADPSSSEPAFAPHNDTDEWALVFTGPDCEGDSWTLRPHGRPATDYLKLRSVFLTPARD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JUJ7</accession>
    <name>A0A2M9JUJ7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CG723_15200</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000004">
        <property type="protein sequence ID" value="PJN10565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN10565">
        <property type="protein sequence ID" value="PJN10565"/>
        <property type="gene ID" value="CG723_15200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PJN10565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="719" mass="77502" checksum="8124D0653C206354" modified="2018-04-25" version="1">MAEKTMTAQELSNLRLGTLDTAVSDWETMSKRLDTLSTGGHGEVSAKDLEAKANEADWKGVNATVSREFVTKTAVEFQDVAGEAASVLGILKDAGAAFKQHKTDLRTAESDLTKRNLHVDAKGGVVRQEASGAAGVGGIHATDEEIEVAQHRITRILWEASETDRIAARALRKLAKSKYDFTGDGPQGLKEADARQGKEDAEYWAKRIKEGDVKDWSDADLRRYNETLKNQRDNPGFTETFATTLGADGTLQFWRDLAAPPGGAVDGDRAKILAEVQDNLSMSLANATHSDSPAMETWKREVVAAGDKPFPIQGLPMGPNGFQVMSSLMGKGKFDGDFMHDYGNAMLKYEREYPGDPKVAWRDSTNLNYPPTDEPNDPVAGFMEGLGHNPEASLKFFDDSTTVDGKKLDNWDYLVAKGDDAREWPLGDDGNPIGHDALGHALESATIGVPYGSDATPPKHSAESAELVNRIVQEFGTNPEQLDDSPMSDSFGNITAEYMRDVQDGLNGEGGIATYGSNANLEALADDGTLKRFLGEVGKDPDAYGAIINSQQAVSTELINGAFHDRDKLGDQLMFEVNNRVSPGAEIAGIMADSRTQAVYDQKIAEDAEFNKGVVTADKWAGRAIDTGLARFPVAGDAAGWVIGDIRESVVEHYTRDSSGEAQVERDKFLATQRSGSASAVYDATYTAATEAGVSDIQAKSMATTASEKVKDSYGQGQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JUR9</accession>
    <name>A0A2M9JUR9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF4440 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_15535</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000004">
        <property type="protein sequence ID" value="PJN10624.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN10624">
        <property type="protein sequence ID" value="PJN10624"/>
        <property type="gene ID" value="CG723_15535"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037401">
        <property type="entry name" value="SnoaL-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13474">
        <property type="entry name" value="SnoaL_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="SSF54427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SnoaL-like" evidence="1">
        <location>
            <begin position="29"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13474"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN10624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="138" mass="15375" checksum="88CBD774DE401B26" modified="2018-04-25" version="1">MSETISTTKTEIDAITAEFFGAFDNRGGSEADVDRIRRLTIPGAVIVSTGPATTAYTVDEFIEPRRKLLSDGRLVEFSEWETTERTQIAGDIAARFGEYRKSGIMNGEPFEGGGTKSIQFVRTPEGWRIASFIWFDRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JUU6</accession>
    <name>A0A2M9JUU6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">SGNH hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CG723_15460</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000004">
        <property type="protein sequence ID" value="PJN10612.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN10612">
        <property type="protein sequence ID" value="PJN10612"/>
        <property type="gene ID" value="CG723_15460"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013830">
        <property type="entry name" value="SGNH_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13472">
        <property type="entry name" value="Lipase_GDSL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="domain" description="SGNH_hydro" evidence="3">
        <location>
            <begin position="231"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="36"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PJN10612.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="440" mass="46500" checksum="57DBD8F4B9D97904" modified="2018-04-25" version="1">MTKRHGYALLAAVAALVVVISAAIYLGVSGAFDGSDSTVSAGPRHPQNSAAPASTGTWSGSWSASPAGGEPGTETDGLAGRTVRNVVHTSIGGTSARITFSNLFGQQPLSITHASVAVAAAPNTPAAAAGTLRRLTFGGNTSVVIPAGSQAMSDAVRLHVPHDADMLVTSYSPTPSGPVTYHPQARQMSYVAQGDRAEDATGAPFTQQTPFWRYVTALDVLSNESDGTVVVIGDSLTDGVTSTVGANRRWTDDLADRLRDENGAARYGVVNQGISGNRILSDGLGRPANNPSGLSRFDRDVLDRSGVKAVVIALGVNDILRNPHQNDPDKIVEGLRELTRQAHTRGLRVVGATLMPFQGHRGYEPRLEGVRQAVNAQIRSGKVFDEFVDFDKALRDPYNPRKLLPAYDSGDHLHPSDSGFRRMADTFNLTTLKGSTPAEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JV11</accession>
    <name>A0A2M9JV11_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Phospholipase C</fullName>
            <ecNumber evidence="2">3.1.4.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CG723_16160</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CB01635</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O = a 1,2-diacyl-sn-glycerol + H(+) + phosphocholine</text>
            <dbReference type="Rhea" id="RHEA:10604"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17815"/>
            <dbReference type="ChEBI" id="CHEBI:57643"/>
            <dbReference type="ChEBI" id="CHEBI:295975"/>
            <dbReference type="EC" id="3.1.4.3"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="5">
            <dbReference type="Rhea" id="RHEA:10605"/>
        </physiologicalReaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial phospholipase C family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.4.3" evidence="2"/>
    <dbReference type="EMBL" id="NNBL01000004">
        <property type="protein sequence ID" value="PJN10726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN10726">
        <property type="protein sequence ID" value="PJN10726"/>
        <property type="gene ID" value="CG723_16160"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034480">
        <property type="term" value="F:phosphatidylcholine phospholipase C activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044003">
        <property type="term" value="P:modulation by symbiont of host process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007312">
        <property type="entry name" value="Phosphoesterase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31956">
        <property type="entry name" value="PTHR31956"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04185">
        <property type="entry name" value="Phosphoesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0134">Cell wall</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0843">Virulence</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014598677" description="Phospholipase C" evidence="7">
        <location>
            <begin position="37"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="427"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="430"/>
            <end position="445"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PJN10726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="476" mass="52655" checksum="658587E35B8EC3AF" modified="2018-04-25" version="1">MPEDFTRRRLLGSAAGALGGAAALSLLPPSVQKAVAAGPPRRGSLRDIEHVVMLMQENRSFDHYFGTLSGVRGFNDPRALKLDTGRSVFYQPDAVNPKGYLLPFHLDTHSSSAQAIPSTSHAWSVQHEAWNGGRMDRWLPAHRKADGANGPYVMGYYTREDIPFQFALAEAFTICDHYFCSVFGPTWPNRLYWMTGSIDAGGTQGGPVLSNKAPTPYRWKTYAERLQAAGVSWKVYQQDDDYGCNMLEQFQAFKDAKPGSDLYERGVRPQPEGTFEDDARGDRLPAVSWIMPTSYQSEHPDYLPAAGADFVASKIEAIASNPKVWAKTAFILNYDENDGLFDHVPPPTAPAGAKGEYVQGLPIGAGFRVPAIIVSPWTVGGWVASETFDHTSALQFLERFTGVEEPNITDWRRDTFGDLTSAFRFSDGRPHAPRLPDDTAEQLEKAKQEVATLPKPTLPGADQHFPHQERGRRPQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JVA7</accession>
    <name>A0A2M9JVA7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CG723_16610</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000004">
        <property type="protein sequence ID" value="PJN10799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN10799">
        <property type="protein sequence ID" value="PJN10799"/>
        <property type="gene ID" value="CG723_16610"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009593">
        <property type="entry name" value="DUF1203"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06718">
        <property type="entry name" value="DUF1203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF034110">
        <property type="entry name" value="DUF1203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PJN10799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="171" mass="18387" checksum="28D94FCFB8747CA3" modified="2018-04-25" version="1">MTTYTAQPIAPATLKELRDTDDAGRPCVAFTATDDAAVGSPLRCCLRSVEPGERIALVSYAPLRRWSEATGAHPGAYDEQGPVFVHADDCEGPAPDAGGYPFDRPGALRTVRRYNAEGHIVGGRLLEIPQDATAGFDAAFAEAFGDPHVALVHVRALEYGCFQFEVRRPQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JVG3</accession>
    <name>A0A2M9JVG3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CG723_16970</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CB01635</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the complex I 51 kDa subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000004">
        <property type="protein sequence ID" value="PJN10860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN10860">
        <property type="protein sequence ID" value="PJN10860"/>
        <property type="gene ID" value="CG723_16970"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1440.230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11540">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011538">
        <property type="entry name" value="Nuo51_FMN-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037225">
        <property type="entry name" value="Nuo51_FMN-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019575">
        <property type="entry name" value="Nuop51_4Fe4S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037207">
        <property type="entry name" value="Nuop51_4Fe4S-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01512">
        <property type="entry name" value="Complex1_51K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10589">
        <property type="entry name" value="NADH_4Fe-4S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00928">
        <property type="entry name" value="NADH_4Fe-4S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140490">
        <property type="entry name" value="SSF140490"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF142019">
        <property type="entry name" value="SSF142019"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADH_4Fe-4S" evidence="7">
        <location>
            <begin position="325"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="179"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="502"/>
            <end position="529"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PJN10860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="529" mass="54603" checksum="C02663FB393E12AF" modified="2018-04-25" version="1">MNTALPDVPEVRVVGLPQLTSGFDLVERLDLDMHLKVHGPLEPMGGEQLAALAGQISLRGRGGAGFPFAKKLRAVAQSAIRRGVRPVVVVNGSEDEPACRKDTVLINRAPHLILDGALLVAEALGARTLVVGVTRDSTEASMQAALLERGLSNRRGAPLRARVQRNPVRMVTGESSALIRSADGGPPVPPGRKVRASDSGVGGAPTLLSNAETFAQLAVAARTGPERYCRTGLRDEPGTILLTLSGAVARPMVLEVPAGVPLRYVLQLAGAPPMPQGVLTGGYHGKWLDAFTAQEAVVSRASLEAAGGALGAGAILPIGPDTCPLGEALRVAQWLASESAGQCGPCYLGLPAAARGLEDVLNGGGPTALEALQQVTRAVKRRGACKHPDGSAAFLESTISAFTDDLAAHVLGGGCGRPVQGVLPLHTEAPQGESPSGRRLAVDWTLCEGHGLCADIIPELIQLGPDGYPSVAEAPVARYSEARAVRAVRRCPALALRIEEDPAAAPARPALPPALPPGRGRRALGSGRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JVK9</accession>
    <name>A0A2M9JVK9_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Elongation factor 4</fullName>
            <shortName evidence="5">EF-4</shortName>
            <ecNumber evidence="5">3.6.5.n1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Ribosomal back-translocase LepA</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">lepA</name>
        <name evidence="7" type="ORF">CG723_17025</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CB01635</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back-translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>GTP + H2O = GDP + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="EC" id="3.6.5.n1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Peripheral membrane protein</topology>
            <orientation evidence="5">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. LepA subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.5.n1" evidence="5"/>
    <dbReference type="EMBL" id="NNBL01000004">
        <property type="protein sequence ID" value="PJN10868.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN10868">
        <property type="protein sequence ID" value="PJN10868"/>
        <property type="gene ID" value="CG723_17025"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045727">
        <property type="term" value="P:positive regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03709">
        <property type="entry name" value="lepA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2570">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00071">
        <property type="entry name" value="LepA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006297">
        <property type="entry name" value="EF-4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035647">
        <property type="entry name" value="EFG_III/V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000640">
        <property type="entry name" value="EFG_V-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004161">
        <property type="entry name" value="EFTu-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031157">
        <property type="entry name" value="G_TR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038363">
        <property type="entry name" value="LepA_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013842">
        <property type="entry name" value="LepA_CTD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035654">
        <property type="entry name" value="LepA_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43512">
        <property type="entry name" value="PTHR43512"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00679">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03144">
        <property type="entry name" value="GTP_EFTU_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06421">
        <property type="entry name" value="LepA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00838">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="SSF50447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54980">
        <property type="entry name" value="SSF54980"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01393">
        <property type="entry name" value="lepA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00301">
        <property type="entry name" value="G_TR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="4 5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="6">
        <location>
            <begin position="17"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="29"/>
            <end position="34"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="148"/>
            <end position="151"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PJN10868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="619" mass="67931" checksum="6F33E10D86E5BC23" modified="2018-04-25" version="1">MPATPNNVPEPSRTAPALIRNFCIIAHIDHGKSTLADRMLQLTGVVDQRQMRAQYLDRMDIERERGITIKSQAVRLPWAPSEDPGNTHILNMIDTPGHVDFTYEVSRSLAACEGTVLLVDAAQGIEAQTLANLYLAMENDLKIIPVLNKIDLPAAQPEKFSEELANLIGCDPDDVLKVSAKTGMGVEALLDKVVAEIPAPVGVADAPARAMIFDSVYDSYRGVVTYVRVVDGQLNKRERIRMMSTGATHELLEIGVSSPEMTPADGIGVGEVGYIITGVKDVRQSKVGDTITSLHNGATVALGGYKDPKPMVFSGLYPLDGSEYPDLREALDKLQLNDAALVYEPETSAALGFGFRVGFLGLLHLDVIRERLEREFGLDLIATAPNVVYRVAMEDGSEHTVTNPSEFPEGKIDKVFEPVVRATILAPSEFIGSIMELCQTRRGTLLGMDYLSEDRVEIRYTLPLAEIVFDFFDQLKSKTRGYASLDYEPTGEQDSSLVKVDILLHGDKVDAFSAVTHKDAAYAYGVRLVAKLRELIPRQAFEVPIQAAIGSRVIARETIRAIRKDVLAKCYGGDISRKRKLLEKQKEGKKRMKMVGSVEVPQEAFIAVLSSDDSGSKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JVR1</accession>
    <name>A0A2M9JVR1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_08230</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN10986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN10986">
        <property type="protein sequence ID" value="PJN10986"/>
        <property type="gene ID" value="CG723_08230"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="205"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="238"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="443"/>
            <end position="462"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN10986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="470" mass="51207" checksum="C222C2ABAF231544" modified="2018-04-25" version="1">MDAWAALRRRFWATLPARLRLLHVSTVSLTAALALLLLLAGLAASGTWDAVADRDSPRTTSAADLNLALNDMDAQAANILLSSGDAGKGRLRTPYGKAVGFYGDARTAIGHDLRTLAVAAQGDRTDERTVESLTDHFAEYQELVGRALENDGRTGGKASALADYRDATDLLQRKLLPESSELVASNNRAFNTQYAQARSALSVQLAAVIVLGVLLLAVLAVLQWYAARRFHRILNPGVLAGTVCVLLATLLGAQALSETAEQLRGARRDAFDSVVALSRARAIAYDANADESRYLLDQERRGQYERAFVANSRKLYGVRGATLATYDDELATTWQAYRSDHEDLRFTGEFRRELDNITFPGERAAAEKAVETYAVYQRDDRKIRALVAQGKEREAVAFGISWQPGMSNAHFGAWMAALDKVTDINRRHFTASVRAGRSAVGGLLPWALGALLAAVALTALGLRPRYAEFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JVW1</accession>
    <name>A0A2M9JVW1_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Gas vesicle structural protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CG723_08400</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CB01635</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Gas vesicles are small, hollow, gas filled protein structures that are found in several microbial planktonic microorganisms. They allow the positioning of the organism at the favorable depth for growth.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the gas vesicle protein type A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN11010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN11010">
        <property type="protein sequence ID" value="PJN11010"/>
        <property type="gene ID" value="CG723_08400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031411">
        <property type="term" value="C:gas vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005773">
        <property type="term" value="C:vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012506">
        <property type="term" value="C:vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000638">
        <property type="entry name" value="Gas-vesicle_GvpA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018493">
        <property type="entry name" value="Gas-vesicle_GvpA_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00741">
        <property type="entry name" value="Gas_vesicle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00234">
        <property type="entry name" value="GAS_VESICLE_A_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0304">Gas vesicle</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0926">Vacuole</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PJN11010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="114" mass="12775" checksum="16DEF102483ACDDF" modified="2018-04-25" version="1">MTDVDLRQTSYPASGPQTTNLADILERVLDKGIVIAGDIKIELLDIELLTIRIRLFVASVDTAKKAGIDWWETDPALSSRASRSALQDENRALRERLEALESKTKDESPEQRPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JVX5</accession>
    <name>A0A2M9JVX5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CG723_08710</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN11053.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN11053">
        <property type="protein sequence ID" value="PJN11053"/>
        <property type="gene ID" value="CG723_08710"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PJN11053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="68" mass="7266" checksum="4CDADF8AE8BDA4FE" modified="2018-04-25" version="1">MVTPLLDGANHLAFFETVEIVSLLTQNPAQADQFVRRALGDLATAPRDLQQAVSAPTFRTSADRPSAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JWX9</accession>
    <name>A0A2M9JWX9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_10760</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN11394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN11394">
        <property type="protein sequence ID" value="PJN11394"/>
        <property type="gene ID" value="CG723_10760"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014644131" evidence="1">
        <location>
            <begin position="28"/>
            <end position="523"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN11394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="523" mass="56125" checksum="F0FA654E137B0E91" modified="2018-04-25" version="1">MTSRALSRALALTMTIAAAGVAYPAQADDIPKAPGHRLVEQYAGAPAKARPVPGQAPPQHPYLAANGRSGMHADAAGSGTYPWSGPLGNKPAVSSEKMAALGGECATVTFDKDGRIVTVCGTFTGFLVKLLDPHSLKTLAEYKLPQRPSTVEAITRLDFSKIFKDTSGGAYSYLDNEDRLVLADSRQHIIRLAHERAADGSWRFRVTDDWDLTGQVPHDCVSWTNLYPSGTCDPVTSVMPDWQGRVWWVTRQGRVGTVDPAGGTIKSIQLPGEEIQNSFSVAEDGVSIVSDHALYSFEAAADGTPKAVWRQTYDRGTGTKPGSVNQGSGTTPDLFGAGEGYVAITDNADDRMNILVYRRGRDVPDDQRLVCKVPVFGSGASTTDNSLISYGNSLVVENNYGYENITSLTFGRSVVGGVTRVDVRKDGSGCDTVWESKVRSPSTVPKLSTANGLLYFYTKDPNSLGIDAWYLTAVDFHTGEPRWKQLAGTGVTYDNNWAPVTLGPDGTAYVGVFNGLVAVRDRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JXB7</accession>
    <name>A0A2M9JXB7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">SAM-dependent methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_11225</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN11468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN11468">
        <property type="protein sequence ID" value="PJN11468"/>
        <property type="gene ID" value="CG723_11225"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransf_11" evidence="1">
        <location>
            <begin position="92"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN11468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="244" mass="26435" checksum="E18FFC42101AFB15" modified="2018-04-25" version="1">MSKNRKDSPLPRVQWPRYGIDAPAFPAVLGAAGAACCLAAGRWRPGRKALATAGTVLIAHTGIYLRTTLHGKLQVWRRELDRADLKGDEQLLDLGCGRGAVLIEAARRLPTGHAVGVDLWSGTDQSGNRPEVTLSNAAAAGVADRVEVRTADMTELPFADGSFDVVTSALAIHNIPSPEERYRAVDEAMRVLRPGGQLIVADFWPMARKYAEHIGRGTLRGLGPEYWYGGPWLGVTLLHAVKER</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JXE7</accession>
    <name>A0A2M9JXE7_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Probable DNA ligase</fullName>
            <ecNumber evidence="12">6.5.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Polydeoxyribonucleotide synthase [ATP]</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="primary">lig</name>
        <name evidence="16" type="ORF">CG723_11410</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">CB01635</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="12 14">Belongs to the ATP-dependent DNA ligase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.5.1.1" evidence="12"/>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN11502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN11502">
        <property type="protein sequence ID" value="PJN11502"/>
        <property type="gene ID" value="CG723_11410"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003910">
        <property type="term" value="F:DNA ligase (ATP) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007049">
        <property type="term" value="P:cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071897">
        <property type="term" value="P:DNA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00407">
        <property type="entry name" value="DNA_ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022865">
        <property type="entry name" value="DNA_ligae_ATP-dep_bac/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000977">
        <property type="entry name" value="DNA_ligase_ATP-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012309">
        <property type="entry name" value="DNA_ligase_ATP-dep_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012310">
        <property type="entry name" value="DNA_ligase_ATP-dep_cent"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016059">
        <property type="entry name" value="DNA_ligase_ATP-dep_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012308">
        <property type="entry name" value="DNA_ligase_ATP-dep_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036599">
        <property type="entry name" value="DNA_ligase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04679">
        <property type="entry name" value="DNA_ligase_A_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01068">
        <property type="entry name" value="DNA_ligase_A_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04675">
        <property type="entry name" value="DNA_ligase_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117018">
        <property type="entry name" value="SSF117018"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00574">
        <property type="entry name" value="dnl1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00697">
        <property type="entry name" value="DNA_LIGASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50160">
        <property type="entry name" value="DNA_LIGASE_A3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 12 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11 12" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2 12" id="KW-0132">Cell division</keyword>
    <keyword evidence="6 12 13" id="KW-0227">DNA damage</keyword>
    <keyword evidence="9 12 13" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="10 12 13" id="KW-0234">DNA repair</keyword>
    <keyword evidence="3 12 13" id="KW-0235">DNA replication</keyword>
    <keyword evidence="1 12 13" id="KW-0436">Ligase</keyword>
    <keyword evidence="8 12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 12 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA_LIGASE_A3" evidence="15">
        <location>
            <begin position="287"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="active site" description="N6-AMP-lysine intermediate" evidence="12">
        <location>
            <position position="210"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="208"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="215"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="230"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="259"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="299"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="377"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="383"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU004196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="PJN11502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="513" mass="54878" checksum="0A7EFFB3166A3EF7" modified="2018-04-25" version="1">MLFSRLAQVSQEVAATRARSRKIALLAELFRAAEPDDVPIVIPYLAGRLPQGRLGIGWRVLREPVAPAAQPRLTVQDVDAALTALGDVAGAGSQAERTRLVGELMGAATGDEQRFLFGLLTGEVRQGALDAVALEGLAQATGAPPEEVRRAVMLTGSLQVVAQALLAEGPDALGEFQLTVGRPVFPMLAHSAPSVGEAVDKLGACAVEEKLDGIRVQVHRDGDVVRVYTRTLDDITDRLPEVTAVAAGLDGDRFILDGEVIALDGDGRPRPFQEIASRVGSRVDVVTAAGSVPVVPVFFDVLYAGGDELLDLPFAERHARLARLVPKVMRVRHVVVPDGEDAAARAAADAFFADTLRRGHEGVVVKGLDAPYSAGRRGASWLKVKPVHTLDLVVLAAEWGHGRRTGKLSNLHLGARRPDGSFAMLGKTFKGLTDALLAWQTERLRELATSDDGHVVTVRPELVVEIAYDGLQKSTRYPAGVTLRFARVVRYREDKTAEDADTVETVLAAHPAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JXG1</accession>
    <name>A0A2M9JXG1_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">FBP_C domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_11815</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN11571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN11571">
        <property type="protein sequence ID" value="PJN11571"/>
        <property type="gene ID" value="CG723_11815"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032330">
        <property type="entry name" value="EF-G-binding_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16571">
        <property type="entry name" value="FBP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FBP_C" evidence="1">
        <location>
            <begin position="8"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF16571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN11571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="168" mass="18021" checksum="F6AF74563321E3E4" modified="2018-04-25" version="1">MEPLNEKQIRASFVNCTKGEATRMKLPLDFAEVPWEDLDFLGWVDPGAPLRAHLVRPGPDGPLGITLRVPSVGRTSAVKSSMCQVCLTGHASSGVALLAAPLAGARGREGNTVGIYLCADLACSLYLRGKRQPKLRAGRYEESLSLDERIARAMSNLDAFAAKVTEVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JXP6</accession>
    <name>A0A2M9JXP6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Amidinotransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CG723_12115</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN11622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN11622">
        <property type="protein sequence ID" value="PJN11622"/>
        <property type="gene ID" value="CG723_12115"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PJN11622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="275" mass="30301" checksum="792A47B7CFAA7725" modified="2018-04-25" version="1">MPRRYLVCEPRYFDVQYAINPWMRDDVRVDTALAIAQWQNLIETYRAHGHTVETVPPVPGLPDMVFAANSALVVAGRVLGSHFHAEQRRPESAEYETWFKAAGYDVHRPESVCEGEGDLVPAGRYVLAGSGFRTTRAAHDEAQEFFGVPVIGLRLVDPYFYHLDTALFALDHPDDPVDPDDPDGGTIAYYPEAFSAGSREVLARLFPSAVLATREDAMAFGLNSVSDGRHVFVAPQATGLIAQLTHRGYVPVPVDLSEFHKAGGGIKCCTQEIRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JXU3</accession>
    <name>A0A2M9JXU3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Epoxide hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_12500</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN11681.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN11681">
        <property type="protein sequence ID" value="PJN11681"/>
        <property type="gene ID" value="CG723_12500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000639">
        <property type="entry name" value="Epox_hydrolase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00412">
        <property type="entry name" value="EPOXHYDRLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="29"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN11681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="327" mass="35174" checksum="E314072299EA7E34" modified="2018-04-25" version="1">MSQQAAQATHRLVDGPAGRIHLVEQGTGPLVLLVHGFPESSYSWRRQLPALAAAGYRAVALDVRGYGRSSKPADPVAYGMLDLVDDNVAVVDALGERSAVLVGHDWGANIAAYSALLRPEVFRAVALLSVPYTPPGGPRPSDVFAGMGGNEEIYVSYFQEPGRAEAEIEPDVRGWLAGIFAALSADTMAAPGAPDPHFVARGGTMRERFPVDRLPAWLDEAELDVYAGEFERTGLTGALNRYRNMDRDWEELAALQGAPVTQPSLFIGGAMDASTTWLSDAIDAYPTTLPGLRSSHILDGCGHWIQQERGDDVNRILVEWLAGLPDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-09-29" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JY12</accession>
    <name>A0A2M9JY12_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Carboxylesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_12325</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN11657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN11657">
        <property type="protein sequence ID" value="PJN11657"/>
        <property type="gene ID" value="CG723_12325"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001466">
        <property type="entry name" value="Beta-lactam-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00144">
        <property type="entry name" value="Beta-lactamase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Beta-lactamase" evidence="1">
        <location>
            <begin position="19"/>
            <end position="373"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN11657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="381" mass="40765" checksum="E85984C934F0333B" modified="2018-04-25" version="1">MEQRNGWADERFGAVADVFARNFTEFPELGAAVTVFAGGRKVVELWGGVADERTGRAWGQDTTVPVFSCAKGLVSLTAHLLAQEGRLDLDAPVSRYWPEFARHGKEAVTTRMVLGHRAGVPALDRVLSFEEIADWTPVIRAIEEQKPLWEPGTAYEYHGHVFGFLVGEVIRRITRLTPGACFRRTVGDPLGLRAWIGLPAVESERVARLVEAEGRPGMPGPEHLLTRIVTMNGALVFPGLDAPHGWNDPELHAMELPGAGAVASASGLAGLYAAAVTGVEGGERLLTTDTVTDAVREVSSGEGWLGFDAGARWGSGFLLDSPSFRPMLGARSFGNDGAGGQFAFGDDEFGVGFAYVANRMIGHGDARANRLIAAVRECLGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JY15</accession>
    <name>A0A2M9JY15_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Amino acid transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_13065</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN11775.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN11775">
        <property type="protein sequence ID" value="PJN11775"/>
        <property type="gene ID" value="CG723_13065"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="65"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="121"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="163"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="190"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="232"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="284"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="341"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="382"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="405"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="434"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="461"/>
            <end position="481"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN11775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="650" mass="70696" checksum="C56BE97562214C53" modified="2018-04-25" version="1">MATTHGPRTSRLRAWMLEGLSDMAKTAPHGAGAAAEPSHKGQPWWRVMCLTGVDYFSTLGYQPGIAALAAGLLSPVATIVLVIVTLVGALPVYRRVAEESPHGEGSIAMLERLLSFWKGKLFVLTLLGFAATDFLITITLSAADASTHLVENPHLTDTLHNKQMVITLVLVALLGAVFLKGFLEAIGVAVVLVGIYLSLNVVVVVTGLWHVITKEHVITDWSTALTAEHGNAFAMIGVALLVFPKLALGLSGFETGVAVMPHVKGDPTDTEEQPKGRIRGAKKLLTTAAAIMSVFLVCTSFITTLLIPEKEFESGGKANGRALAYLAHEYLGNTFGTVYDISTIAILWFAGASAMAGLLNLMPRYLPRYGMAPHWARAVRPMVIVFTLVAFLVTWIFNADVDAQGGAYATGVLVLICSAAIAVTIAARKARQRNWTIGFAVISAVFLYTTVVNVIERPDGVKIGACFIAGIILVSLLSRLARAFELRVTHVTFDSMAERFVRDIASRKVRFIANEPDNRDLAEYRAKIDQIRHDNDVPAHEDFVFVEVTVVDPSEFEGDLNVRGEVLHGRYRVLTLEGSSIPNALAALLLHIRDTTGRVPHIYFEWTEGNPLANFLRFFLFGQGEVAPVTREVLREAEPDPARRPHVHVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JYG7</accession>
    <name>A0A2M9JYG7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CG723_13895</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN11912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN11912">
        <property type="protein sequence ID" value="PJN11912"/>
        <property type="gene ID" value="CG723_13895"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PJN11912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="185" mass="20391" checksum="136582D330B0ADCE" modified="2018-04-25" version="1">MTGDHDAELDLAVRLLAGTPTHEGRDPLMLRQWALTAEQFGSRMAPDPGPVRVVERDGGLAAGLLARYRSRPPVVEIYVDTVDRAEQLIAERDWRHWFPEGSVRAAALAHEQAHAWLHHAHVRADFKRALGHTAMRLGRRRLYAHVAGADELAAHAYARAACGLGRSPLLLTEALAAFVSCESEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JYH2</accession>
    <name>A0A2M9JYH2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Amidohydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_13975</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN11924.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN11924">
        <property type="protein sequence ID" value="PJN11924"/>
        <property type="gene ID" value="CG723_13975"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017439">
        <property type="entry name" value="Amidohydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036264">
        <property type="entry name" value="Bact_exopeptidase_dim_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002933">
        <property type="entry name" value="Peptidase_M20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011650">
        <property type="entry name" value="Peptidase_M20_dimer"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11014">
        <property type="entry name" value="PTHR11014"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07687">
        <property type="entry name" value="M20_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01546">
        <property type="entry name" value="Peptidase_M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005962">
        <property type="entry name" value="Pept_M20D_amidohydro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55031">
        <property type="entry name" value="SSF55031"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01891">
        <property type="entry name" value="amidohydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="M20_dimer" evidence="1">
        <location>
            <begin position="197"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN11924.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="417" mass="44288" checksum="AAE944C8A972F8AF" modified="2018-04-25" version="1">MSKTVTAQLPEIRDELAAFYKDLHQNPELSLQETRTAGLLAQRLRDAGFDEVAEGIGITGVVGLLRNGEGPVVMLRADFDALPVEEKTGLPYASQARGVDNEGRDVPVMHACGHDMHAACLTGAAMLLAQARDQWRGTLLVVFQPAEELAVGARGMVDDRLFERFPKPEIVLGQHVGPLPAGVIGYGTGPVMAAADSLNITLHGRGGHGSRPEASIDPVLMAANVVTRLQGIVAREVPPAETAVVTVGRLQAGTKDNIIPDKAELGVNVRTFTPAIRDKVRNAIERIVTAESQASGAEQPPDFDWTGAAPALVSEPAATQTTVAAFAEHFGQQRIMPMPQVNASEDVGVFGEVLGVPTVFWFWGGLDTETVLTALAEDRLDELPANHSPHFAPLVEPTLSTGVEALVVAALEWLADA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JYM2</accession>
    <name>A0A2M9JYM2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Two-component sensor histidine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CG723_14120</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN11948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN11948">
        <property type="protein sequence ID" value="PJN11948"/>
        <property type="gene ID" value="CG723_14120"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011712">
        <property type="entry name" value="Sig_transdc_His_kin_sub3_dim/P"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07730">
        <property type="entry name" value="HisKA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="40"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="65"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="domain" description="HisKA_3" evidence="4">
        <location>
            <begin position="186"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="336"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="384"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="161"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF07730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PJN11948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="414" mass="44098" checksum="CC8C5AF495DAF6FA" modified="2018-04-25" version="1">MTAKRPGAQARVRVKDVLLAAVVFLLSMVAVSIIHEQHRISIRWQAVVLLGTSSFALVWRRRHPFGVLVVAVACAVVLQSLGFREGPLGTSSVILSVYTVAACTDRRTTWTTACVSASVLVGAALVTDPRTWLSPDNAAMLAWTALPAAIGDGVRSRRAYVAAVEERAEHAERTREQEARQRVAAERMRIARELHDVVAHHIALINAQAGVAVHLVEQRPEHVLTALEGIRDVSQSALDELRVTVSLLRQPDETAAPRDPTPGMGHVPDLLASFDRAGLAVKQTVSGDPQPLPPAADLAAYRIIQEALTNVRKHSGVDQARLDLSYLPNLLTITVQDDGPSQPTRSDPGKGHGLIGMRERAGTVGGRVQAGPRAEGGFTVTAELPLLSGTAEGEPASAGTDETGSRGTAEEGRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-06-02" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JYN9</accession>
    <name>A0A2M9JYN9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_14335</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN11985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN11985">
        <property type="protein sequence ID" value="PJN11985"/>
        <property type="gene ID" value="CG723_14335"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="45"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN11985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="63" mass="6423" checksum="E2539AA42E1BD46B" modified="2018-04-25" version="1">MPAIASTRTRCGTGRFPHSFSTTLSMAGTPNPAPGTRRLPVATASSCAAGTSVTADNSLDRSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JYW1</accession>
    <name>A0A2M9JYW1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">TetR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_14865</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN12073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN12073">
        <property type="protein sequence ID" value="PJN12073"/>
        <property type="gene ID" value="CG723_14865"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="16"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="38"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN12073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="187" mass="20374" checksum="25C6F8F177B46DB4" modified="2018-04-25" version="1">MSASIPSAKPARADARRNYEALLAAGRNVFMRDGTDAPMDDVAKEAGVGRATLYRHFPSREHLFVAIMQDRVDLLDTQAREFLGAPDVWEALVQWLLRYDRSATEYRGMSTRVGDGLADDGSPMASACAPMKASFARLFARAQDEGAVRGDVTAVQLLALISALPKHAEHDASADAYLDIVLRGLRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JZ79</accession>
    <name>A0A2M9JZ79_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Acyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CG723_12860</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN12193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN12193">
        <property type="protein sequence ID" value="PJN12193"/>
        <property type="gene ID" value="CG723_12860"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002656">
        <property type="entry name" value="Acyl_transf_3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043968">
        <property type="entry name" value="SGNH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01757">
        <property type="entry name" value="Acyl_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19040">
        <property type="entry name" value="SGNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="74"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="114"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="210"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="235"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="263"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="290"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="321"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="359"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="398"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl_transf_3" evidence="3">
        <location>
            <begin position="48"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="domain" description="SGNH" evidence="4">
        <location>
            <begin position="477"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF19040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PJN12193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="716" mass="76624" checksum="9AD558B560EB3C47" modified="2018-04-25" version="1">MRARTHAGQAATEPATRSTGTGEEEPASDAGRTAPPPGATHAAPGQRPDIQGLRALAVTLVVLGHAGVTRFSGGYVGVDVFFVISGFLITSSLLRELSASDRISIRAFYARRALRLLPASALVVLVTLAGSWLFLSKIRFAEYMSDAFASALYAVNFRLAATGTDYLAEGSPPSPFQHFWSLAVEEQFYLVWPLLLFLGWRLSRRRRALLAIPLVALCAVSFGLSVHVTGQSAPWAYFGSHTRAWELGVGALVALLRPPRLPAGVAVAMTWAGLACIIAAALRFDADTPFPGTAAAAPVIGAALVIVGGTSPAWPGARRMLTARPVTWLGGLSYSWYLWHWPFLVIGPKALDRPAGTHLELALGAAALLPAWLTLRLVENPVRFHRALRGRPGRGLRLGLALTAVTASTALIAAAFPPSISSGEPAPVLKDALAAAPDPGARLTKALGTTGTRLPDNLTPPLTGITDIRSAVYRDGCHQNYAGTSAPMCVYGDRSSKYVVVLFGDSHAAQWFPALNVLALQHHWKLISMTKASCKAATVTIVNAHRPYTTCDRWRADALSRIEKLRPSLVLVSSSDAGTPAQTMRDPLAGWTDGYARTFRKLSRSGARLVALLDTPWPREDVLDCAAIHPLHLRDCSVRVPKALHDVTRRNATKAAARSTGVSVIDPQPWLCTTHGDCPVAVYDTFVYRDESHMAEGYAEALAPVLGRALEVRSGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JZK4</accession>
    <name>A0A2M9JZK4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">6-phosphogluconate dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CG723_04470</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CB01635</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HIBADH-related family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000002">
        <property type="protein sequence ID" value="PJN12315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN12315">
        <property type="protein sequence ID" value="PJN12315"/>
        <property type="gene ID" value="CG723_04470"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016054">
        <property type="term" value="P:organic acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002204">
        <property type="entry name" value="3-OH-isobutyrate_DH-rel_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006115">
        <property type="entry name" value="6PGDH_NADP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015815">
        <property type="entry name" value="HIBADH-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03446">
        <property type="entry name" value="NAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000103">
        <property type="entry name" value="HIBADH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="SSF48179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00895">
        <property type="entry name" value="3_HYDROXYISOBUT_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD_binding_2" evidence="4">
        <location>
            <begin position="3"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000103-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF03446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PJN12315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="269" mass="27152" checksum="9DB50E4C074C33F4" modified="2018-04-25" version="1">MEKIAFLGLGHMGAPMARHLLDAGHPLTVWNRTPAKAAPLVERGAVLAGTPADAVRDADVVITMLATPDAVSEVADAIAPELRPGTYWAEMSTIGPDAVRQLAARLGDGVTLVDAPVMGSTDKAEAGELGILAGGDADRIEGVLAHLGTVTRTGAPGSGAALKLVVNTAVIGGVGLVAEAMALADALGLPEDVAKGALAAGPLGGAVARAFAQGVHFGSDLAVKDIALATETTELPAMEAVLGHFKQAAADPSLVHEDIARAVTRIRER</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JZL0</accession>
    <name>A0A2M9JZL0_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Aldose 1-epimerase</fullName>
            <ecNumber evidence="3">5.1.3.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CG723_04410</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CB01635</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>alpha-D-glucose = beta-D-glucose</text>
            <dbReference type="Rhea" id="RHEA:10264"/>
            <dbReference type="ChEBI" id="CHEBI:15903"/>
            <dbReference type="ChEBI" id="CHEBI:17925"/>
            <dbReference type="EC" id="5.1.3.3"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 3">Carbohydrate metabolism; hexose metabolism.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 3">Belongs to the aldose epimerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.1.3.3" evidence="3"/>
    <dbReference type="EMBL" id="NNBL01000002">
        <property type="protein sequence ID" value="PJN12304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN12304">
        <property type="protein sequence ID" value="PJN12304"/>
        <property type="gene ID" value="CG723_04410"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00242"/>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004034">
        <property type="term" value="F:aldose 1-epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019318">
        <property type="term" value="P:hexose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015443">
        <property type="entry name" value="Aldose_1-epimerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008183">
        <property type="entry name" value="Aldose_1/G6P_1-epimerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014718">
        <property type="entry name" value="GH-type_carb-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01263">
        <property type="entry name" value="Aldose_epim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005096">
        <property type="entry name" value="GALM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="SSF74650"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014676902" description="Aldose 1-epimerase" evidence="7">
        <location>
            <begin position="29"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="6">
        <location>
            <begin position="114"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="6">
        <location>
            <begin position="214"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="4">
        <location>
            <position position="214"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="4">
        <location>
            <position position="352"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="286"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR005096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR005096-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR005096-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR005096-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PJN12304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="386" mass="41431" checksum="FA5DD24AA7E49601" modified="2018-04-25" version="1">MELSRRTLLASGAAAGAAATALGGTAHASASASGSRRPVKELFGKLADGTRIYRWSLENGGTRLKVLSYGGIVQSLEIPDRHGRYVNVSLGYDTIEDYVAGTTFFGATIGRYGNRIANGRFALDGTTYQLSVNDGANSLHGGAKGFNTRVWDVEDFNSGSDVGLKLHYTSVDGEMGYPGTLKVTVTYTLGPSGDWRIDYEATTNKATVVNLTNHTYYNLAGEGSGGIYDHELTLAASRYTPTDSGLIPTGERAKVTGTPFDFRSAKPIGRDIRTAHPQLVTAKGFDHNWVLDKGITARPVHFATLRDPSSGRTLEIATDQPGVQFYSGNFLDGTLTGPSGRTYRQGDGLCLETQHFPDSPNHPAFPSTVLRPGETYRTTTVHSFST</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JZM4</accession>
    <name>A0A2M9JZM4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_04575</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000002">
        <property type="protein sequence ID" value="PJN12335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN12335">
        <property type="protein sequence ID" value="PJN12335"/>
        <property type="gene ID" value="CG723_04575"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010427">
        <property type="entry name" value="DUF1023"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06259">
        <property type="entry name" value="Abhydrolase_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN12335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="402" mass="42774" checksum="736FF49D484F89C0" modified="2018-04-25" version="1">MTSFDSSPQLSVWRALLALAVVFVMLATTGWTAVRHKGVTSPVNAAITAWEHGHLNGRALPDPDGSPARLAQFFAALTSQQRTRLVAHYPLAVGNMNGAPLELRYRANRIALDQARKVARRSTHDNRLSAAGQRDAGQRMNRYASLMRPDRKILAFDPLGTGRVAEVFGDLDKAQRVSVVVPGVDTNLLTFQRTVRKYSAPVGMARSLYRAERAAGPGTRTAVIAWADYTTPAGLGVDAATAMRAKEGATRLNALVRALPGRTPVALYCHSYGSVVCGVAAHKLPSRVSDIAVAGSPGMRAEKAAKLGTHARVWAMRDSDDWIQDVPYLEVGGIGHGADPVSRGFGARVLSAAGARGHTGYFEPGTESLSNFADIGIGSYRTLRCASGHDTCRDGSSGTTSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JZX2</accession>
    <name>A0A2M9JZX2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Sulfate ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CG723_05115</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000002">
        <property type="protein sequence ID" value="PJN12425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN12425">
        <property type="protein sequence ID" value="PJN12425"/>
        <property type="gene ID" value="CG723_05115"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="11"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="296"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="298"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="43"/>
            <end position="50"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PJN12425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="335" mass="34507" checksum="BDAF8000E5096831" modified="2018-04-25" version="1">MTMTDGTPVAVSFTGAVKTFGAVRAVDGVDLEIRRGETVALLGRNGAGKSSTIALLLGLDTPDEGTVSLFGTTPEEAVRAGQVGAMLQEGRAVPRVTVRELVAFVAGRYPAPMPVADALALAGIEELAQRRVDKLSGGQTQRVRFAVALAGNPALLVLDEPTAALDVEARHAFWASMRAYARRGHTVLFSTHYLEEADAHADRIVVIDHGKVVAVGSGEELKRAAGGSLVSFDLAGRGTEGLSLLPGVTAVEVRGDRARLRTDDSDATVIALAGLNAIRGLEVAPASLDDAFMALTSGSDGRSGSGTDSGSDSGSDSGSDNRPGSGSDTDLETVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-06-02" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K0L4</accession>
    <name>A0A2M9K0L4_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 6">Imidazoleglycerol-phosphate dehydratase</fullName>
            <shortName evidence="5">IGPD</shortName>
            <ecNumber evidence="5 6">4.2.1.19</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">hisB</name>
        <name evidence="7" type="ORF">CG723_06410</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CB01635</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5 6">
            <text>D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate = 3-(imidazol-4-yl)-2-oxopropyl phosphate + H2O</text>
            <dbReference type="Rhea" id="RHEA:11040"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:57766"/>
            <dbReference type="ChEBI" id="CHEBI:58278"/>
            <dbReference type="EC" id="4.2.1.19"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 5 6">Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 6/9.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5 6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 6">Belongs to the imidazoleglycerol-phosphate dehydratase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.19" evidence="5 6"/>
    <dbReference type="EMBL" id="NNBL01000002">
        <property type="protein sequence ID" value="PJN12654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN12654">
        <property type="protein sequence ID" value="PJN12654"/>
        <property type="gene ID" value="CG723_06410"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00031">
        <property type="reaction ID" value="UER00011"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004424">
        <property type="term" value="F:imidazoleglycerol-phosphate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07914">
        <property type="entry name" value="IGPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00076">
        <property type="entry name" value="HisB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038494">
        <property type="entry name" value="IGPD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000807">
        <property type="entry name" value="ImidazoleglycerolP_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020565">
        <property type="entry name" value="ImidazoleglycerP_deHydtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23133">
        <property type="entry name" value="PTHR23133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00475">
        <property type="entry name" value="IGPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00954">
        <property type="entry name" value="IGP_DEHYDRATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00955">
        <property type="entry name" value="IGP_DEHYDRATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 5 6" id="KW-0368">Histidine biosynthesis</keyword>
    <keyword evidence="4 5 6" id="KW-0456">Lyase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000599"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PJN12654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="197" mass="21578" checksum="2C4CB2D21032850C" modified="2018-04-25" version="1">MSRVGRVERTTKETSVLVEIDLDGTGKVEVSTGVGFYDHMLDQLGRHGLFDLTVKTEGDLHIDTHHTIEDTALALGAAFKQALGDKVGIYRFGNCTVPLDESLAQVTVDLSGRPYLVHTEPENMAPMIGSYDTTMTRHILESFVAQAQIALHVHVPYGRNAHHIVECQFKALARALRYASERDPRAAGILPSTKGAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K0V3</accession>
    <name>A0A2M9K0V3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF397 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_06980</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000002">
        <property type="protein sequence ID" value="PJN12749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN12749">
        <property type="protein sequence ID" value="PJN12749"/>
        <property type="gene ID" value="CG723_06980"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007278">
        <property type="entry name" value="DUF397"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04149">
        <property type="entry name" value="DUF397"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF397" evidence="1">
        <location>
            <begin position="14"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN12749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="70" mass="7273" checksum="26989350064ED970" modified="2018-04-25" version="1">MSGAVAGPNSDELTWFKSSYSAGNGGECVEVASRLGLTHVRDSKDEAGPIVSLTATAWTEFVGFAARHTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K0W8</accession>
    <name>A0A2M9K0W8_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="12 13 14">UvrABC system protein B</fullName>
            <shortName evidence="13">Protein UvrB</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Excinuclease ABC subunit B</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="primary">uvrB</name>
        <name evidence="20" type="ORF">CG723_07125</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">CB01635</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10 13">The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. Upon binding of the UvrA(2)B(2) complex to a putative damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11 13 14">Forms a heterotetramer with UvrA during the search for lesions. Interacts with UvrC in an incision complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13 14">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="13">The beta-hairpin motif is involved in DNA binding.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 13 14">Belongs to the UvrB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000002">
        <property type="protein sequence ID" value="PJN12775.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN12775">
        <property type="protein sequence ID" value="PJN12775"/>
        <property type="gene ID" value="CG723_07125"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009380">
        <property type="term" value="C:excinuclease repair complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009381">
        <property type="term" value="F:excinuclease ABC activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009432">
        <property type="term" value="P:SOS response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00204">
        <property type="entry name" value="UvrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006935">
        <property type="entry name" value="Helicase/UvrB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001943">
        <property type="entry name" value="UVR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036876">
        <property type="entry name" value="UVR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004807">
        <property type="entry name" value="UvrB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041471">
        <property type="entry name" value="UvrB_inter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024759">
        <property type="entry name" value="UvrB_YAD/RRR_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24029">
        <property type="entry name" value="PTHR24029"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04851">
        <property type="entry name" value="ResIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02151">
        <property type="entry name" value="UVR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12344">
        <property type="entry name" value="UvrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17757">
        <property type="entry name" value="UvrB_inter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46600">
        <property type="entry name" value="SSF46600"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00631">
        <property type="entry name" value="uvrb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50151">
        <property type="entry name" value="UVR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="15" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3 13" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 13 14" id="KW-0227">DNA damage</keyword>
    <keyword evidence="6 13 14" id="KW-0228">DNA excision</keyword>
    <keyword evidence="9 13 14" id="KW-0234">DNA repair</keyword>
    <keyword evidence="8 13 14" id="KW-0267">Excision nuclease</keyword>
    <keyword evidence="4 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13 14" id="KW-0742">SOS response</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="18">
        <location>
            <begin position="35"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="19">
        <location>
            <begin position="438"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="domain" description="UVR" evidence="17">
        <location>
            <begin position="670"/>
            <end position="705"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="641"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="15">
        <location>
            <begin position="265"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="15">
        <location>
            <begin position="666"/>
            <end position="712"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Beta-hairpin" evidence="13">
        <location>
            <begin position="101"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="48"/>
            <end position="55"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00025647"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00026033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00029504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU003587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="PJN12775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="715" mass="80123" checksum="B1766338544072CB" modified="2018-04-25" version="1">MRPVSKIERTVAPFEVVSPYQPSGDQPAAIADLERRITAGEKDVVLLGATGTGKSATTAWMIEKLQRPTLVMAPNKTLAAQLANEFRELLPNNAVEYFVSYYDYYQPEAYVPQSDTYIEKDSSINEEVERLRHSATNSLLTRRDVVVVASVSCIYGLGTPQEYVDRMVSLKVGDEIDRDDLLRRFVDIQYTRNDVAFSRGTFRVRGDTIEIFPVYEELAVRIEMFGDEIESLSTLHPLTGEVISDDESLYVFPATHYVAGPERLERAANDIEKELGERLAELEKQGKMLEAQRLRMRTTYDLEMLRQIGSCSGVENYSMHFDGRSPGSPPNTLLDYFPDDFLLVIDESHVTVPQIGAMYEGDASRKRTLVDHGFRLPSALDNRPLKWEEFQERIGQTVYLSATPGKYELARGDGFVEQIIRPTGLIDPEVVVKPTEGQIDDLVHEIRKRTEKDERVLVTTLTKKMAEDLTEYFLELGIQVRYLHSDVDTLRRVELLRELRAGEYDVLVGINLLREGLDLPEVSLVAILDADKEGFLRSGTSLIQTIGRAARNVSGQVHMYADKITPAMEKAIDETNRRREKQIAYNTEKGIDPQPLRKKINDIVASIAREDVDTEELLGSGYRKGAKDGKGAKAPVPALAKAGAKKTGGKAAKGKTAQTVPTDRPAAELAGQIEEMTDRMRAAAADLQFEIAARLRDEVSEMKRELRQMKEAGLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K0Y0</accession>
    <name>A0A2M9K0Y0_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Nucleotide-binding protein CG723_07205</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_07205</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Displays ATPase and GTPase activities.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the RapZ-like family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000002">
        <property type="protein sequence ID" value="PJN12791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN12791">
        <property type="protein sequence ID" value="PJN12791"/>
        <property type="gene ID" value="CG723_07205"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00636">
        <property type="entry name" value="RapZ_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005337">
        <property type="entry name" value="RapZ-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30448">
        <property type="entry name" value="PTHR30448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03668">
        <property type="entry name" value="ATP_bind_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005052">
        <property type="entry name" value="P-loopkin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="25"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="51"/>
            <end position="58"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="102"/>
            <end position="105"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN12791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="327" mass="35761" checksum="58B5038984124E5A" modified="2018-04-25" version="1">MNENEQGEQAPQPAPDDPAGQAAETDGAQVSTGTTSETPEAAIPELVIISGMSGAGRSTAAKCLEDLGWFVVDNLPPALIPTMVELGARSQGNVARIAVVVDVRGRRFFDDLHQSLADLESRQVTRRIVFLESSDEALVRRFESVRRPHPLQGDGRIVDGIAAERTLLRELRGDADLVIDTSSLNVHELRAKMDAQFAGDEEPELRATVMSFGFKYGLPVDADLVVDMRFLPNPHWVPELRPFTGLNEEVANYVFGQPGAKEFLDRYTELLQLIAAGYRREGKRYVTIAVGCTGGKHRSVAMSEKLAARIAAEGVETVVVHRDMGRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K101</accession>
    <name>A0A2M9K101_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RNA polymerase-binding protein RbpA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">rbpA</name>
        <name evidence="4" type="ORF">CG723_07245</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CB01635</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Binds to RNA polymerase (RNAP), stimulating transcription from principal, but not alternative sigma factor promoters.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="2">Bind 1 Zn(2+) per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Forms a complex with the RNAP catalytic core and with free principal sigma factors.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RNA polymerase-binding protein RbpA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000002">
        <property type="protein sequence ID" value="PJN12799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003976875.1">
        <property type="nucleotide sequence ID" value="NZ_NNBL01000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN12799">
        <property type="protein sequence ID" value="PJN12799"/>
        <property type="gene ID" value="CG723_07245"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001000">
        <property type="term" value="F:bacterial-type RNA polymerase core enzyme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045893">
        <property type="term" value="P:positive regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.28.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01483">
        <property type="entry name" value="RbpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038638">
        <property type="entry name" value="RbpA_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025182">
        <property type="entry name" value="RNApol-bd_RbpA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018527">
        <property type="entry name" value="Rubredoxin_Fe_BS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13397">
        <property type="entry name" value="RbpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00202">
        <property type="entry name" value="RUBREDOXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="60"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="35"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="39"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="57"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="60"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PJN12799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="111" mass="12066" checksum="0494E90BF0CEB611" modified="2018-04-25" version="1">MASGNAIRGSRVGAGPMGEAERGESAPRLRISFWCSNGHETQPSFASDAQVPETWDCPRCGFPAGQDRDNPPDPPRTEPYKTHLAYVRERRSDADGEAILAEALAKLRGEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K185</accession>
    <name>A0A2M9K185_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Cobalamin biosynthesis protein CbiX</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CG723_07675</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000002">
        <property type="protein sequence ID" value="PJN12881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN12881">
        <property type="protein sequence ID" value="PJN12881"/>
        <property type="gene ID" value="CG723_07675"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002762">
        <property type="entry name" value="CbiX-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01903">
        <property type="entry name" value="CbiX"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="278"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="281"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PJN12881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="310" mass="33526" checksum="E11912A6FC5CCD7C" modified="2018-04-25" version="1">MTTPPALLIAGHGTRDEAGAEAFRDFVRELGRRRPDLPVAGGFIELSPPPLTEAVGELVERGVRRFAAVPLMLVSAGHAKGDIPAALAREKERHPGISYTYGRPLGPHPSLLQVLERRLDEALGGGARTPEDRADVTVLLVGRGSTDPDANAEVHKAARLLWEGRGYAGVETAFVSLAAPDVPSGLDRCVKLGARRVVVLPYFLFTGILPDRVRQQTEGWASAHPDVEVLSADVIGPEPELIDLVMERYEEAVRGDLRMNCDTCVYRIALPGFEDKVGLPQQPHFHPDDDGDHPGHGHAHGHGHSHSHAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K1M0</accession>
    <name>A0A2M9K1M0_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">CopD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CG723_07890</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CB01635</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000002">
        <property type="protein sequence ID" value="PJN13032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN13032">
        <property type="protein sequence ID" value="PJN13032"/>
        <property type="gene ID" value="CG723_07890"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006825">
        <property type="term" value="P:copper ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032694">
        <property type="entry name" value="CopC/D"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008457">
        <property type="entry name" value="Cu-R_CopD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34820">
        <property type="entry name" value="PTHR34820"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05425">
        <property type="entry name" value="CopD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="27"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="64"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="104"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="193"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="238"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="280"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="317"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="domain" description="CopD" evidence="8">
        <location>
            <begin position="234"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF05425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PJN13032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="340" mass="34545" checksum="35ED56B46A3DFF60" modified="2018-04-25" version="1">MRQTTEAPAPGGDDTAPHARRPATGRAVAALVLVAAATVIPLLGPSAVLDGTGEAAAPGVTGVALLRTLLFAALCVQLGELFAARLTQRVPGAPPGDGPRSWSAYAPWAGFLAALGLASIVANGNLVPHALSDLDIAGLYGTRDGTLALLEVNAFVVAALCARSRHPATALAPLAAVVVGEALRVHPPAEHTAYLGSALTLVHLTCAALWVGGLLHVLRTLRRWRTTAPEAGAALLGLYARVAAVLLAAITATGVCSTLRRMPVSTVLDQLVTTAYGRTLLAKVILVAVVSVLALVARGRQRNGGLGAAYAPARAEVAVLGVVVAVSAVLTALPLPIRWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K219</accession>
    <name>A0A2M9K219_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Peptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CG723_00515</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000001">
        <property type="protein sequence ID" value="PJN13120.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN13120">
        <property type="protein sequence ID" value="PJN13120"/>
        <property type="gene ID" value="CG723_00515"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.70.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011055">
        <property type="entry name" value="Dup_hybrid_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016047">
        <property type="entry name" value="Peptidase_M23"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01551">
        <property type="entry name" value="Peptidase_M23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51261">
        <property type="entry name" value="SSF51261"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014929080" evidence="2">
        <location>
            <begin position="45"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M23" evidence="3">
        <location>
            <begin position="154"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="87"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PJN13120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="262" mass="26909" checksum="DE0FABDBEDBE2AE4" modified="2018-04-25" version="1">MAFTRATGKHRRPSRLTRTTAQVAGVAALTTTGVIGGLAAPALAADDAAVEQTGLTKAIAIGDSLAEQIDAQAAAQQQAADEAAAKKKAEAEAEKKAEEDRRKAAAKAKAEREAKERAARAAERKRLNAFVIPVTGSYVSTAYKASSGLWSSGSHTGIDFHAASGTSVHAVGAGTVVEAGWGGAYGNNIVIKMNDGTYTQYGHLSSIGVSVGRTVTPGQQIGLSGATGNVTGPHLHFEARTSPEYGSDIDPVAYLRSHGVNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K269</accession>
    <name>A0A2M9K269_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Glyco_trans_2-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CG723_01120</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CB01635</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CDP-glycerol glycerophosphotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000001">
        <property type="protein sequence ID" value="PJN13221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN13221">
        <property type="protein sequence ID" value="PJN13221"/>
        <property type="gene ID" value="CG723_01120"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047355">
        <property type="term" value="F:CDP-glycerol glycerophosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019350">
        <property type="term" value="P:teichoic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12580">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007554">
        <property type="entry name" value="Glycerophosphate_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043148">
        <property type="entry name" value="TagF_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043149">
        <property type="entry name" value="TagF_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04464">
        <property type="entry name" value="Glyphos_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0777">Teichoic acid biosynthesis</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_2-like" evidence="6">
        <location>
            <begin position="8"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022944"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PJN13221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="913" mass="102720" checksum="052FF693A24B6B6C" modified="2018-04-25" version="1">MNSYDVTLVVPVYNVEQYLHECLDSIAAQTVFERCEVILVDNGSSDGSYRLCADFALRHANVTVLVRHGGGAGAARNLGMDRATGARIAFCDSDDVLPPTALERLLDAAVTTGAQVVVGAMETFPKATRWAWKDHFGKGDRTFASIAEAPELVHSASACNKLFDLSYLRTHRIRFAEGVHFEDAYVGVTALVRASRIALVDACVYKYRKRAAGNSTMDAIWTRRQNYWDHLQLVEYLHGLGSAVPASSRAVLDLFLVRSYQGFALRAPELFQGAELEELYARCRAVYWNVSPDVVVAATADGRHRVAYYAFITGDFGLFADRAARLHGISVRDGRPYLADAVPDGLAPLVEATPFTAHVEHVRRLPGTRMLRISGRFEVCGMPLVRPLPGRLGLRVRGSRLSAPATQVRRRDMKNLRPDTEWGGFTADLPLDALRPGVHDLEFVLDTEGGQTVTPCLVAAGFLRGARVVRHRGTRVVPHWRGSNRAILMVVGSSRGLGRRIRGGLLAKDAKHVLRRRPFWKQRLARLLTKPLFLGRDIRLFGERGDTAQDNGRHLFRHERTAGKRRGAYYVIRAGSPDRAHLAGLGHVVAHSSWKHKLLMLHASALINAYDIDTYMLPDGWDRTRYLKHLNWRVGARRVFLQHGVTDKDVSKGLHRNRTGVDLILAVSRHEGEFLSAELGYEGQVAVTGFPRFDALVPDRGGRRILFMPTWRAYLTVPSYSRDGGGGEAERAMQDRFLASTYRDFMVRFLNDPALLAALERYDYTLDFLPHYEMRAVVGEMAPDHERVRIIDQNEISVQDAMRRCDLFITDWSSTAFDVAYLGTPLVYAQFDAEEYWDGHYRKGYFDAHRDGFGPVGETVEGVVGEVIRYVQRGCEREPEYLRRVEKFFEHHDQQNNVRASEAIERLIRGLNH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K278</accession>
    <name>A0A2M9K278_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Glyco_trans_2-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_01130</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000001">
        <property type="protein sequence ID" value="PJN13223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN13223">
        <property type="protein sequence ID" value="PJN13223"/>
        <property type="gene ID" value="CG723_01130"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047355">
        <property type="term" value="F:CDP-glycerol glycerophosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12580">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007554">
        <property type="entry name" value="Glycerophosphate_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043148">
        <property type="entry name" value="TagF_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04464">
        <property type="entry name" value="Glyphos_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glyco_trans_2-like" evidence="1">
        <location>
            <begin position="10"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN13223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="915" mass="105507" checksum="769CD23CDF8DAD3E" modified="2018-04-25" version="1">MFDPVYDVAVVVPIFNVERYLQECLDSLARQTMFDRCQVILVDNGSSDSSPAIAAGFAARHQNVWAFVHPTGKAGGARNAGMDLVSSRYITFCDSDDVLPEDALEVMWRTAVKERVPLTIGRMETFPEPTNWPWLRYFGTNVQVHPGIENIPEMIHGGSACHKLFDVEFIRANNIRFREGVHFEDAFFSVPAMLLADRIAMVPSTVYQYRKRAAEDSTMDKLWERKANYWDHLLLEEYLMTLRPRLSGHRQEVLNRFLVRSYQGFALRAPQAMDEQELFQLFTRARAVYTQLTPDAVMASTHDTRHRVPFLAMYMNWFELFARPEHAITGVYGRAGDLYLDLSVPSALLPLTKVSSTSVHVERVQEDPESDGIVVAGRFVLNGLPMNRPMRNPMQLWPETSGQMVTARQVWRSDLKATRDDLEWGGFEAVVPVRAIKDGEFPLKLVFCTSGRDVSRTCMTTTAMLRSARGMNVGGRWVLPMSKGKDNAVLLVREVQGKGRGADKDWEEFLQGMDEDQKKRKAPFWRARAIRRATLRFFRRKEIWLIAERKDTAQDNSLHLFRYLRTHERRRKAYYIIDKDSADRAKLKRLGNVVAHSSWKHKLLMLHASLLINAYDIDSYMLPDGWDRGQYLKHLNWRVGAKRVFLQHGVTDEDGSKALHRNRTGVDLVFATSDREAQYFSEHMHYGEQAKALGFPRFDALQPDRGGRRILLMPTWRKYLTIPSYLQQEGADQDAVNEIFRESAYRDFVVRLLRDPKLMEALEYYDYTLDFLPHYEMRNMIDGVVPDHPRVQRLDQTKVSVQTALRQCDLFITDWSSVHFDMAYLGTPLVYARFDPDEYWAKHARKGYFEAEHDGFGPVCGNVDEVVTEVIRYLGNGCAREPEYDRRARAFFAFEDRDNCARATAAIAELAASDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K2I0</accession>
    <name>A0A2M9K2I0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Flavin-nucleotide-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CG723_01825</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000001">
        <property type="protein sequence ID" value="PJN13344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN13344">
        <property type="protein sequence ID" value="PJN13344"/>
        <property type="gene ID" value="CG723_01825"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024747">
        <property type="entry name" value="Pyridox_Oxase-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12900">
        <property type="entry name" value="Pyridox_ox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PJN13344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="230" mass="24599" checksum="46508ED77292EAB7" modified="2018-04-25" version="1">MTQTDIATTLSRTLPQTDRTRHSRLREQASLERSDLEAILDAGFVCHLGVLVDGRPVVVPTVYGRDDTRLYLHGSVASRSLAAEPDGPICVTVTHVDGLVLARSVFEHGVNYRSAMIHGVPHTVTDPDEKLAGLRRLTEHATPGQWTYARQPSRKELAATTLLVLSLDEASVKIRTGAPDDGDGPDAALGLWAGTLPLTSRWGAPTADPLLPTGITAPAHIVARAGTRQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K2I4</accession>
    <name>A0A2M9K2I4_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ricin B-type lectin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_01760</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000001">
        <property type="protein sequence ID" value="PJN13332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN13332">
        <property type="protein sequence ID" value="PJN13332"/>
        <property type="gene ID" value="CG723_01760"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00161">
        <property type="entry name" value="RICIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035992">
        <property type="entry name" value="Ricin_B-like_lectins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000772">
        <property type="entry name" value="Ricin_B_lectin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00652">
        <property type="entry name" value="Ricin_B_lectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00458">
        <property type="entry name" value="RICIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50370">
        <property type="entry name" value="SSF50370"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50231">
        <property type="entry name" value="RICIN_B_LECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014793060" description="Ricin B-type lectin domain-containing protein" evidence="1">
        <location>
            <begin position="31"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="domain" description="Ricin B-type lectin" evidence="2">
        <location>
            <begin position="262"/>
            <end position="374"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN13332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="375" mass="38921" checksum="B5DABB861E61F390" modified="2018-04-25" version="1">MRRFRSIRSVCVTAVVAVAATLGLSAPAQAAGQTPGTYTNYGFPSGTTALTEATWGTTVEADPGRGNVYWAHQFDFTNSVGGYVGQQRWRTGTGMFLFSLWGSTAAKAGSAGTYCQTFDESGTGYTCRYNQAFAAGHHYTYRVSPDTTDGWYKATISDVTAGTSFVLGSLQVGSGARISAGGMVDWVEYFDWNSNSATCEDEPYSRARLDLPKGTSTGGPAVTASVSSTSTSSTCTQYAGVTQVSGGSVHDDATGNSASGDITGSGGKCVDITGGSSTDGTPLELWTCGGGNHQNWVLSHDGTVRALYKCMTVSGSSVQLSTCNGSAAQQWQRSGDTLVNQGKCLDAEGGASTDGTKLITYTCSGGANQRWTTPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K2R3</accession>
    <name>A0A2M9K2R3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DNA-binding response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CG723_02300</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000001">
        <property type="protein sequence ID" value="PJN13425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN13425">
        <property type="protein sequence ID" value="PJN13425"/>
        <property type="gene ID" value="CG723_02300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00622">
        <property type="entry name" value="HTH_LUXR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="4"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="domain" description="HTH luxR-type" evidence="3">
        <location>
            <begin position="139"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PJN13425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="208" mass="21765" checksum="84A7DC12884EAC21" modified="2018-04-25" version="1">MTVRLLLADDHPVVRAGLRAVLDAEPDFEIAAEAATAERAVELAAAGGIDVVLMDLQFGAGMHGSEATAAIAARPGAPRVLVLTTYDTDADILAAVEAGASGYLLKDAPPEELAAAVRTAASGQSALAPAIAHRLMDRMRAPAEALSRRELEVLQLVRDGLSNQRISKELFLSQATVKSHLVHIYAKLGVDSRTAAVAAATARGLMRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K3K6</accession>
    <name>A0A2M9K3K6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Damage-inducible protein CinA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_00055</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000001">
        <property type="protein sequence ID" value="PJN13714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN13714">
        <property type="protein sequence ID" value="PJN13714"/>
        <property type="gene ID" value="CG723_00055"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.950.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036653">
        <property type="entry name" value="CinA-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008136">
        <property type="entry name" value="CinA_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02464">
        <property type="entry name" value="CinA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF142433">
        <property type="entry name" value="SSF142433"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00199">
        <property type="entry name" value="PncC_domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CinA" evidence="1">
        <location>
            <begin position="3"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN13714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="198" mass="20386" checksum="0D46B5949551B0B6" modified="2018-04-25" version="1">MLRLLTERGETLAVAESLTGGLVAADITSVPGASRVFRGSVTSYATELKRDVLGVDGTLLAERGAVDPEVALQMATGVRRVLGADWGIATTGVAGPDEQDGQPVGTVFVAVAGPGDSMAFEARSGGADAGTGAGVEGVGGQAGSFARSRKVAALRLNGDRSEIRMKSVRSVLELLLERLLSERAENERAQDTEQNGGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JEX4</accession>
    <name>A0A2M9JEX4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">S9 family peptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_44555</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000048">
        <property type="protein sequence ID" value="PJN05434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN05434">
        <property type="protein sequence ID" value="PJN05434"/>
        <property type="gene ID" value="CG723_44555"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008236">
        <property type="term" value="F:serine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001375">
        <property type="entry name" value="Peptidase_S9"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00326">
        <property type="entry name" value="Peptidase_S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase_S9" evidence="2">
        <location>
            <begin position="409"/>
            <end position="624"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN05434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="629" mass="68912" checksum="43AA2B08838D7A05" modified="2018-04-25" version="1">MALPKPISVEELFAPPIRSRASLSPDGTKIAYLAPWGNHLNLWIESVDAPGDARRVTSEDRNLLSYHWTDDPRWLLYTRDQGGDENRHLYRVDLEDPDAGATDLTPFPGARIMDLKLPAAQPGKAVFSSNSRNPAAFDLFELDIATGDLQTLAENPGGAATTLFYGGSGDPFTSDVTEQGDLNLSRWNEATQTLRHIAQFDGADYPLGVYPLEVTADAGVLFGSNRGSDRLRLARLDAETGEETEVDSHPQYDLDTRARVFPALPSPLIFSRRTGELIGVRYLGERLVINALDPHFAEVLENLRNLSDGDLAHISSDESEQRWVVSFTHDRDPGATYFYDHSSGESRLLFRPLGHLDPEQLAPMTPVTITARDGLALPSHLTLPIGTEPHRLPLVLLVHGGPWDRDSWGFNPLVQLLANRGYAVLQVNFRSSTGYGKSFMKAGIGELAGKMHDDLIDGVNWAIQQGYADPDRVAILGGSYGGYAALVGVTFTPDVFAAAVDIFGVSDLANFLRNQPEFVQPALAANWFRWVGDPADPQQEADMLARSPISQVDQARTPLLIAQGANDARVAQAESDNMVQALRARGVPVEYILMADEGHSIENPENLIAVYHAVEHFLDEHLGDGRDAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JF11</accession>
    <name>A0A2M9JF11_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 11">Delta-aminolevulinic acid dehydratase</fullName>
            <ecNumber evidence="4 11">4.2.1.24</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CG723_45125</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">CB01635</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>2 5-aminolevulinate = H(+) + 2 H2O + porphobilinogen</text>
            <dbReference type="Rhea" id="RHEA:24064"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58126"/>
            <dbReference type="ChEBI" id="CHEBI:356416"/>
            <dbReference type="EC" id="4.2.1.24"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Porphyrin-containing compound metabolism; protoporphyrin-IX biosynthesis; coproporphyrinogen-III from 5-aminolevulinate: step 1/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Homooctamer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the ALAD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.24" evidence="4 11"/>
    <dbReference type="EMBL" id="NNBL01000050">
        <property type="protein sequence ID" value="PJN05393.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN05393">
        <property type="protein sequence ID" value="PJN05393"/>
        <property type="gene ID" value="CG723_45125"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00251">
        <property type="reaction ID" value="UER00318"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004655">
        <property type="term" value="F:porphobilinogen synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006782">
        <property type="term" value="P:protoporphyrinogen IX biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001731">
        <property type="entry name" value="ALAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030656">
        <property type="entry name" value="ALAD_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11458">
        <property type="entry name" value="PTHR11458"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00490">
        <property type="entry name" value="ALAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001415">
        <property type="entry name" value="Porphbilin_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00144">
        <property type="entry name" value="DALDHYDRTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01004">
        <property type="entry name" value="ALAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00169">
        <property type="entry name" value="D_ALA_DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0350">Heme biosynthesis</keyword>
    <keyword evidence="7 11" id="KW-0456">Lyase</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 11" id="KW-0627">Porphyrin biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Schiff-base intermediate with substrate" evidence="9">
        <location>
            <position position="203"/>
        </location>
    </feature>
    <feature type="active site" description="Schiff-base intermediate with substrate" evidence="9">
        <location>
            <position position="255"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="240"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00020771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR001415-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR001415-5"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU004161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PJN05393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="329" mass="35308" checksum="EBB56E9E5D3571C4" modified="2018-04-25" version="1">MTEYGSFPGARPRRLRTTPAMRRMVAETRLHPADLILPAFVREGISEPVAIGSMPGVVQHTRDTLKKAAVEALEAGVSGIMLFGVPDDAKKDALGTAGTDPDGILQVALRDVRAEVGDDLIVMSDLCLDEFTDHGHCGVLDAEGRVDNDATLERYAEMAQVQADAGAHVVGPSGMMDGQVGVVRDALDTIGKEDVSILAYTAKYSSAFYGPFREAVGSSLTGDRKTYQQDPANVRESLRELALDLEEGADMVMVKPAGPYLDILAKVAESVDVPVAAYQISGEYAMIEAAAQRGWIERDRAILETLLGIKRAGANMILTYWATEVARGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JF41</accession>
    <name>A0A2M9JF41_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_45010</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000049">
        <property type="protein sequence ID" value="PJN05423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN05423">
        <property type="protein sequence ID" value="PJN05423"/>
        <property type="gene ID" value="CG723_45010"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="6"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="28"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN05423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="180" mass="19296" checksum="74C9A7028C218995" modified="2018-04-25" version="1">MRSDAARNRQRIFDEARGAVIGGETALTLNELARRAGVGVGTVYRVFPTQRVMRESVLEEAVRELVDAATVAGGYPDPAKALIDFLRTALLTALARPGLTDVLITGSDETDSLHRAKGELVDVTSHLLVRIRPAPALTGENLLKLLCGLIHAVSEHPAERQGAAIDNYLDILRAGLAPTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JF76</accession>
    <name>A0A2M9JF76_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CG723_44645</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000048">
        <property type="protein sequence ID" value="PJN05472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN05472">
        <property type="protein sequence ID" value="PJN05472"/>
        <property type="gene ID" value="CG723_44645"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007344">
        <property type="entry name" value="GrpB/CoaE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34822">
        <property type="entry name" value="PTHR34822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04229">
        <property type="entry name" value="GrpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="SSF81301"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PJN05472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="187" mass="20956" checksum="AD5CE9199AC60642" modified="2018-04-25" version="1">MMNSSKPRRPDVTTVEIIGGPEALEVGLGSYDARWAEVYLHHRRRILDALAAVDVDVEHIGSTSVPGLAAKPIVDIVVAVADITAEEDYLDGLLAAGYELRVREPGHRLVRTPTRDVHVHVYERGDAAVHEYLLFRDHLRTHADDRALYESVKRGLLSQQWNDMNDYADAKNDVILAIKTRARSARQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-05-25" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JF89</accession>
    <name>A0A2M9JF89_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Amino acid oxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_43915</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000045">
        <property type="protein sequence ID" value="PJN05558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN05558">
        <property type="protein sequence ID" value="PJN05558"/>
        <property type="gene ID" value="CG723_43915"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045170">
        <property type="entry name" value="MTOX"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10961">
        <property type="entry name" value="PTHR10961"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DAO" evidence="2">
        <location>
            <begin position="7"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN05558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="366" mass="38995" checksum="E29CCF7387E35CB2" modified="2018-04-25" version="1">MDRVPEVAVVGAGIVGLCTAYALAERGTTARVYESGVPGHGQSNGQSRIFRHAHDDARLVEFARQGRAVWDEWADRLGAELISQDGVVALGDSVPERLRILQEAGGIRARALDSAELHARMPLLADYRGPAMLDEDGGAIRTRVAVESLVDALGDSVVTDEVISLHPTGRGTVEVLSAVGREEYATAVVCAGLGTARLARNVGLSLPIRPAAHVRLTFQVRGAPPERVACLQDSSGDFGEVGVYAAPYPGNSRYAVGLSQTVEVREDGSFVDPEALAALGDRARAYVSRALPGLDPEPVEHLRCWVTSLPWSEDGMAVWEADRIFFAAGHNLFKQAPRLGRALAGAAMAEELEENLRPAAALGQPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JFG0</accession>
    <name>A0A2M9JFG0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">TetR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_44315</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000046">
        <property type="protein sequence ID" value="PJN05543.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN05543">
        <property type="protein sequence ID" value="PJN05543"/>
        <property type="gene ID" value="CG723_44315"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039532">
        <property type="entry name" value="TetR_C_Firmicutes"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14278">
        <property type="entry name" value="TetR_C_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="12"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="35"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN05543.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="210" mass="23516" checksum="DD5E5DDBDAAD94AC" modified="2018-04-25" version="1">MDMNPAGDRRVRRTRAALRQALVELVLDRGFQAITVEQITERADVGRATFYAHYRDKEDLLVGIVRDLAQDRERLLPAVQQAHAEGFTGLPVKYIFEHAEQEKPVYRVILRGEGDGRALREFTDLICAHAEAAFRTRTQQLAVTPRIPLEVVARAWTGELIGLLTWWVENDTGYSAAEITAHLRDLSVYGRVWATGLTPSDAPGALDLAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-06-02" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JFL1</accession>
    <name>A0A2M9JFL1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_43460</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000043">
        <property type="protein sequence ID" value="PJN05671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN05671">
        <property type="protein sequence ID" value="PJN05671"/>
        <property type="gene ID" value="CG723_43460"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="41"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="46"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN05671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="64" mass="8078" checksum="E89DBE3C38E4FDBE" modified="2018-04-25" version="1">MPDQGRRDRRQDPEPEDAEDGRRRLRAQFLRELAESRELRDRVRPRRARAARMRQQMRMRTFRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JFL3</accession>
    <name>A0A2M9JFL3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CG723_44285</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000046">
        <property type="protein sequence ID" value="PJN05537.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN05537">
        <property type="protein sequence ID" value="PJN05537"/>
        <property type="gene ID" value="CG723_44285"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PJN05537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="121" mass="13583" checksum="AE6A3F76D1F66AEB" modified="2018-04-25" version="1">MGVFVSIRGWLECDEQQLAAARQVIAHHSDGHYSGGWGFPDHHFNWTYYVFYGGDVRESAVNWFLDQLRCIAALPASDEDGDRVLGLFVVSSEVAPQVEWQVRGGSVIPRPTDDRLAYLAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JG75</accession>
    <name>A0A2M9JG75_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">RNA polymerase subunit sigma-24</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CG723_42685</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CB01635</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000040">
        <property type="protein sequence ID" value="PJN05842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN05842">
        <property type="protein sequence ID" value="PJN05842"/>
        <property type="gene ID" value="CG723_42685"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1320">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.1060">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041916">
        <property type="entry name" value="Anti_sigma_zinc_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013222">
        <property type="entry name" value="Glyco_hyd_98_carb-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038637">
        <property type="entry name" value="NPCBM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039425">
        <property type="entry name" value="RNA_pol_sigma-70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43133">
        <property type="entry name" value="PTHR43133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08305">
        <property type="entry name" value="NPCBM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00776">
        <property type="entry name" value="NPCBM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="SSF49785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="NPCBM" evidence="6">
        <location>
            <begin position="505"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="422"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="441"/>
            <end position="509"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PJN05842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="650" mass="67874" checksum="62AE3D9FCB42444A" modified="2018-04-25" version="1">MSVDGRDEPLENSGAGDTGTGGLPARQVPSQGGPRRDDSPGSEPPGPSAPAGPSDAAGEGRSDLSVPQQREHGVDPGTSVLPPPRETPPADADLITCMRSGDDTAYEELYRRHSAAVRRYARTCCRDGHTADDLTAEVFARMLQAVRGGSGPEHAVRAYLLTTVRRVAAGWTKSAKREHLVEDFAVFAQQAARSSEVSDDDTLDLGADVLAMHEAEQSMAMQAFRSLPERWQAVLWHTEVEDESPSEVATLFGLDANGTRVLAKRAREGLKEAYLQAHVSTTLTQDEECARYADRLGAYARGSLRTRAERGLRKHLEECAKCRLAAGQIKEVASGIPGVVPVAVIGWFGAAGYAKVVALIGGGAASAAGAGAAAAAGGSSGGAAGGGAAASEGLGAPVKAGIAAGVVAAGVAVAVAIALAGDPHKPKPEARKEKPAVSQPITPSKPTPPPKPKPEPPAPPQPTPPPEPAPKPTPTPKPTPKPTPPPKPTPKPTPEPTPKPTPPPPAPAVYQLNQLSYAGLGDGTKPEIRPGESSWVWQRYGLRVADKQYANGVTVHANSTVTIDLNRSCTAYDAFAGVDDMTLGTGAVRFSVYADGVRLWRSQVLRGGDPAVPVHLNLAQRKAIRLVTEPQTNFDSLAVGDWAESRFTCR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JGB6</accession>
    <name>A0A2M9JGB6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA primase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_42055</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000038">
        <property type="protein sequence ID" value="PJN05918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN05918">
        <property type="protein sequence ID" value="PJN05918"/>
        <property type="gene ID" value="CG723_42055"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015330">
        <property type="entry name" value="DNA_primase/pol_bifunc_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09250">
        <property type="entry name" value="Prim-Pol"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00943">
        <property type="entry name" value="Prim-Pol"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Prim-Pol" evidence="1">
        <location>
            <begin position="23"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN05918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="362" mass="37827" checksum="0026CB1E26152342" modified="2018-04-25" version="1">MAFELLVPDSDSGGQARRALATAHWFAGRGWPVHPLSPGRKTPAGSCADCRAPGHSYEGCGCMVEGRWCHGFRAATLDAARINRWWGANSRLGVGISCGPAGLVVIDIDAHERQLPDRGRLLPGIPIAEQVDLTGLANGFHTLGVLAALRGATSPAQDTSTMRVRTPSGGLHVWYRAQPGRRYQCSTGSGGGRALAWQVDVRAHGGYIVAPGTVTDAGPYTAMGPVREPAPLPAWLARELDRTGHLPRPPAPRPVVPRARQAVIAAGGGRTTASRVLRASLADVSACAAVPEGAAFSEKLNRAAYIAGGLVAAGHLDADEAERSLTEAAALARGGQERRCASIIRSGLRAGQLHPLHPGGRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-06-02" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JGE1</accession>
    <name>A0A2M9JGE1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_41960</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000038">
        <property type="protein sequence ID" value="PJN05902.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN05902">
        <property type="protein sequence ID" value="PJN05902"/>
        <property type="gene ID" value="CG723_41960"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="35"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="41"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN05902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="62" mass="6598" checksum="27E137A22DB7221B" modified="2018-04-25" version="1">MDVPALRERLIWLIASGVLDLGLERVRAFRLDAVNDASGTPPRTADLSAAPSSSHPSADRAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-09-29" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JGY5</accession>
    <name>A0A2M9JGY5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CG723_40940</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000035">
        <property type="protein sequence ID" value="PJN06113.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN06113">
        <property type="protein sequence ID" value="PJN06113"/>
        <property type="gene ID" value="CG723_40940"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PJN06113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="165" mass="17888" checksum="34D355323F82E4D1" modified="2018-04-25" version="1">MSKPLPLAVEFQLSDGWAPASTETIDSFGVAFAALHPHPDAGFAANITIDGEIPPDDVSLSDLADASVRRLEQAAESVQLVDRREVGPDDAPALVQRFLLSAAVNDELRELAQVQVYLPLADTVDPHKYAVIKLALTATTEQLHEVLEEFQDFVRTVRPSTSEGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JH65</accession>
    <name>A0A2M9JH65_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">IS5/IS1182 family transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CG723_40605</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CB01635</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000034">
        <property type="protein sequence ID" value="PJN06205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN06205">
        <property type="protein sequence ID" value="PJN06205"/>
        <property type="gene ID" value="CG723_40605"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027806">
        <property type="entry name" value="HARBI1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027805">
        <property type="entry name" value="Transposase_HTH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13359">
        <property type="entry name" value="DDE_Tnp_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13613">
        <property type="entry name" value="HTH_Tnp_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH_Tnp_4" evidence="4">
        <location>
            <begin position="32"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="domain" description="DDE Tnp4" evidence="3">
        <location>
            <begin position="111"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PJN06205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="279" mass="31564" checksum="1B3BA67196F73934" modified="2018-04-25" version="1">MARPWVVGVEGRRYQTRGGARKRAPGAGARHQLVFVDRLVATLIHLRHDLPHAVLALLYGVDRSTVTRAVGEVRQLLAGRGFAVADRPGVRLRTMDDVFAYAQTEGVRLRMDATEIQVRRPTAGRGGRRAFVSGKKKQNTMKATVIADHQGRTLWTDALRPGRMHDATAARLAGIGRCFDAFDRVQVLLDDGYLGLSRDHRGKALTQPRELRPGATLPFLEHNERQRHEHSSQRITVEHALADHKRWKQLQRWTHRRDRLPDTYQAIATLVSDRSITPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JHG8</accession>
    <name>A0A2M9JHG8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Crotonase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_40000</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the enoyl-CoA hydratase/isomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000032">
        <property type="protein sequence ID" value="PJN06328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN06328">
        <property type="protein sequence ID" value="PJN06328"/>
        <property type="gene ID" value="CG723_40000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018376">
        <property type="entry name" value="Enoyl-CoA_hyd/isom_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00166">
        <property type="entry name" value="ENOYL_COA_HYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN06328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="261" mass="27825" checksum="B8DC086E4F22B01F" modified="2018-04-25" version="1">MSAPTTDAALSVVRLSWEGPVAVVTMDDPGGRNTFSAGLTSGLVDSIEQAAADPRTRAVVVEGRPELFCAGGTQRELVNFARGNGSFDTDDFFRVFARCPLPVIASVQGHAIGGGLVLALYADFAVFSERSMYAGNFMKYGFTPGMGASYLFPSRFGRELGTEMLFTARNYRGAELRERGAPVRVVPHQDVPGTARELALSMTGAPRASIELLKRELAVPLLAATGEAVAREAALHRTSFRLPEVMERIVGAYGTAATDTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JHH4</accession>
    <name>A0A2M9JHH4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">HNH endonuclease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_40700</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000034">
        <property type="protein sequence ID" value="PJN06207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN06207">
        <property type="protein sequence ID" value="PJN06207"/>
        <property type="gene ID" value="CG723_40700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011089">
        <property type="entry name" value="DUF1524"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07510">
        <property type="entry name" value="DUF1524"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF1524" evidence="1">
        <location>
            <begin position="93"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07510"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN06207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="214" mass="23323" checksum="8748748830E4974E" modified="2018-04-25" version="1">MAVLAIPTATTAQAAPGPFGSPGDVITTPLQYALKALPIADEDRTGYQRTSFKHWIDADKDGCNTRAEVLKAEAFMTPEQGLKCKLTGGRWYSEYDDQYIDGASGLDVDHRVPLAEAWDSGASRWTAAERQAYANDLGDDRALIAVSAKSNRSKADQDPATWMPPAASDHCDYLRDWIVVKVRWQLAIDPAEQSALSDDLAQCPNAPVKVTLAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JHI5</accession>
    <name>A0A2M9JHI5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Acyl-CoA dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_39870</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000032">
        <property type="protein sequence ID" value="PJN06303.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN06303">
        <property type="protein sequence ID" value="PJN06303"/>
        <property type="gene ID" value="CG723_39870"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016627">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="SSF47203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="SSF56645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN06303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="597" mass="63373" checksum="51A162248B5FC831" modified="2018-04-25" version="1">MTGTLTPRAPAAAGAGPPAPPRTAADEAPLDGAERAAWIEALLGDPDDPHNPHGYRCLLDADDRRRVPEATEELLTDARLTAEFVPRELGGRLARPDVLARVLRPVFRRDVALGFGYGITSLFGASAVWAAGDDRQRARTAALLLDGGGGRVTILHHELAHANAILRDEFTARSAPGGFVLGGRKDVVINADRADAFVMYARTATTAGPRSHSVLLLDPERLPPGGLRRLQRVPTPGMRGSRFAGLEFTDSRVRADTLVGEVGDGVSLALRTFMVNRCLIPGTVVAGVDSALRFAVRAATAGRPAGQPARRHHTVLAGVFADLLACDSMAVTGLRALSLLPDSAHLMAAAVKLTMPDLLREDLEELATVLGFHGYDRGPLYGGFQKLVRDLPVAGLGHAGSAACQAVLIPQLRTLARTSWFRTEEPTARLFLLSAPVPALDYRKLTLSGSDDVLTATLVGAGERLGALRPAGPQWAALADLADAFVQEMRALREQCAALPESVRATLADPRACALADRYALVLAAAACLGVWQGQDGTDSFLSQPAWAVLALSRIGRRLGVPVPELPDGVTESVLSEVLLRFREGRSLDVYDTRIAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JHU5</accession>
    <name>A0A2M9JHU5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ricin-type beta-trefoil lectin domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CG723_39110</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000030">
        <property type="protein sequence ID" value="PJN06423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN06423">
        <property type="protein sequence ID" value="PJN06423"/>
        <property type="gene ID" value="CG723_39110"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00161">
        <property type="entry name" value="RICIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039743">
        <property type="entry name" value="6GAL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039514">
        <property type="entry name" value="6GAL-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035992">
        <property type="entry name" value="Ricin_B-like_lectins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000772">
        <property type="entry name" value="Ricin_B_lectin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42767">
        <property type="entry name" value="PTHR42767"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14587">
        <property type="entry name" value="Glyco_hydr_30_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14200">
        <property type="entry name" value="RicinB_lectin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50370">
        <property type="entry name" value="SSF50370"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50231">
        <property type="entry name" value="RICIN_B_LECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0430">Lectin</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014780107" evidence="2">
        <location>
            <begin position="27"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="domain" description="Ricin B-type lectin" evidence="3">
        <location>
            <begin position="570"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="651"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="654"/>
            <end position="675"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PJN06423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="675" mass="72246" checksum="BE8D2645E7D8CB16" modified="2018-04-25" version="1">MARLTRRRFIGIAAATAAAAGTQLSAAPLAAAAAAAVTVTPDPSYRQERFEGWGTSLVWFANATGHYPDEIRERIADLAFGRDGLALNIARYNIGGGNAPDVPAYLRPGGAVEGWWKAPEGTTRTDTDWWDPDNGDHWNGDADATQRWWVDRIKKDITHWETFSNSPPYFMTVSGYVSGGFDASKDQLKEASVDDFATYLAGATRRLEKAHGIKVKTVDPCNEPNTSYWGTKLGADGNPTGGRQEGCHIGPALQQKIVPALHAALKKARTTAVVSAMDETNPTTFTTNWTSYPADVKSHVTQMNVHTYGTGGRTSVRDLAKADGKPLWMSEVEGDWGDGQSFTDMRPGLGLAQHIVDDLRELEPSAWVFWQPVEDWDNMKPGGESAEGGNWGEIQVSFSAGPDDTLETCPVHTNTKFDTARNFTHYIRPGDHLIKTDDTSSTAAVTRGGNGATVVHVNSTTSSRTVTLDLSKFGTVRQGATVTPVVTSTDGKLAEQTPVAVTGRTATFTVPAQSVTTFVIKGVSGVTKDAATLRKGRTYELTGVQSGKDLSVADGGSTLVIKSGTGAAGQRWRLAQISGEGPANRRRHVFTSAADGRRLAVRDGAPVVEPDRDERDAAAQWILSTTGDGTYTLVNAGTGRLLEVGGQATHEGAPVGTWQPNSGSNQRWKVTDVTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JHV0</accession>
    <name>A0A2M9JHV0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Excinuclease ABC subunit A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">uvrA</name>
        <name evidence="15" type="ORF">CG723_39405</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000030">
        <property type="protein sequence ID" value="PJN06459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN06459">
        <property type="protein sequence ID" value="PJN06459"/>
        <property type="gene ID" value="CG723_39405"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009380">
        <property type="term" value="C:excinuclease repair complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004518">
        <property type="term" value="F:nuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004602">
        <property type="entry name" value="UvrA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041552">
        <property type="entry name" value="UvrA_DNA-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17755">
        <property type="entry name" value="UvrA_DNA-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00630">
        <property type="entry name" value="uvra"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0227">DNA damage</keyword>
    <keyword evidence="6" id="KW-0228">DNA excision</keyword>
    <keyword evidence="12" id="KW-0234">DNA repair</keyword>
    <keyword evidence="11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="10" id="KW-0267">Excision nuclease</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="ABC transporter" evidence="14">
        <location>
            <begin position="480"/>
            <end position="810"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="514"/>
            <end position="521"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="PJN06459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="822" mass="88406" checksum="2BF0F1819C0044D5" modified="2018-04-25" version="1">MNKDGTDPFVHVRGASENNLRNIDVDVPRDAMVAFTGVSGSGKSSLAFGTLYAEAQRRYFESVAPYARRLLQQVGAPHVQEITGLPPAVALQQRRGSPSSRSTVGTITTLSNLLRMLYSRAGTYPPRAARLEAESFSPNTAAGACPECHGLGVVHDVAEDLLVPDPSLSIREGAIAAWPGAWQGANLRSVVSGLGIDIDRPWRRLRKKDRDWLLYTDEQPSVYIEPEEDRVDYGYQGKFWSARKHVMHVLADSKSEKMRERALRFVRSVPCPECHGSGLRPEALAVTFAGRSIAEINAMPLTEVVALLRPVAGRSEADATTSTARSGETSEAAVRICGDLVARVDVLLDLGLGYLSLGRRSTTLSPGEAQRLRIATQLRSGLFGVVYVLDEPSAGLHPADAEPLLDVLDRLKAAGNSLFVVEHDMDVVRRADWVVDIGPRAGEGGGRVLYSGPVAGLERVGESATSQYLFGRAQPLDHRTRTPHGWLHLSGVSRHNLHDVSVDVPLCVLTAVTGVSGSGKSTLVTQVLAEVVRGHLGLVPEEPDEAQLEVDVQDASGVESFDRLVRVDQRPIGRTPRSNLATYTGMFDAVRKLYAATDEARARGYSAGRFSFNVPEGRCETCQGEGFVAVELLFLPGTYAPCPTCQGARYNAETLEVTYRGKNIAEVLALSVDAAAKFLSAVPAASRSLETLREVGLGYLRLGQPATELSGGEAQRIKLASELQRARRGHALYLLDEPTAGLHPSDIALLLRQLHRLVDAGNTVVLVEHDLDTIATADWVIDLGPGGGDAGGRVVAAGPPAKVARARRSVTAPYLAARLARS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JHZ3</accession>
    <name>A0A2M9JHZ3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">C4-dicarboxylate transporter DctA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CG723_39660</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CB01635</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000031">
        <property type="protein sequence ID" value="PJN06377.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN06377">
        <property type="protein sequence ID" value="PJN06377"/>
        <property type="gene ID" value="CG723_39660"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015293">
        <property type="term" value="F:symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046942">
        <property type="term" value="P:carboxylic acid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3860.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001991">
        <property type="entry name" value="Na-dicarboxylate_symporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018107">
        <property type="entry name" value="Na-dicarboxylate_symporter_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036458">
        <property type="entry name" value="Na:dicarbo_symporter_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42865">
        <property type="entry name" value="PTHR42865"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00375">
        <property type="entry name" value="SDF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF118215">
        <property type="entry name" value="SSF118215"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00714">
        <property type="entry name" value="NA_DICARBOXYL_SYMP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0769">Symport</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="58"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="88"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="160"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="196"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="231"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="319"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="362"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="438"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="444"/>
            <end position="461"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PJN06377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="461" mass="47515" checksum="55C622F31C0CBB0C" modified="2018-04-25" version="1">MPQSVPSLPRRAARVLRTSLFAQVACALVIGVVVGRLWPHAGTAVQPLGDGFVRLIKAMIAPLVFCVVVAGITKAGDLKAFGRIGLKALLWFEVATTVALVVGLLAGNLAGPGVGMNVDPSKLDASAVEDKTGGGSLPSTGDFILHSLPDSAVGAFAENSLLQVLVLACLVGAALLHLGNTKVPAILPAIEQGQEVVFAVVGFIMKLAPLAVFGATAHLVGEYGLGALSTYGKLIGVCYAVAVIFLVLLGLAMKAVTGLSLWKFVRYAREELLLALGTASSETVMPRMMQKLRHAGCRDDAVGLVLPTGYSFNLDGASIYLSIGTLFIAQAVGVDLSLGQQITVVIVLMLTSKGMAGVPGSAFLALSATASALGVIPAGAVALLLGVDRIMDAMRVSTNLLGNCVAVFVVSRWEGALDTARAKKVLGGEIAFVPEEDRAEQVQSPVLAKSQDPKSAAETVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-05-25" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JI38</accession>
    <name>A0A2M9JI38_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_38885</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000029">
        <property type="protein sequence ID" value="PJN06534.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN06534">
        <property type="protein sequence ID" value="PJN06534"/>
        <property type="gene ID" value="CG723_38885"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="SSF47473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EF-hand" evidence="1">
        <location>
            <begin position="2"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="1">
        <location>
            <begin position="39"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN06534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="71" mass="7853" checksum="0BE88A55AD78870B" modified="2018-04-25" version="1">MADIEEARKAFQRFDADGDGFITAVEYKSAMAQMGDFNVTESVAEALIARQDANGDKVLSFDEFWANLNKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JIA7</accession>
    <name>A0A2M9JIA7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Serine protease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CG723_37715</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CB01635</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000027">
        <property type="protein sequence ID" value="PJN06626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN06626">
        <property type="protein sequence ID" value="PJN06626"/>
        <property type="gene ID" value="CG723_37715"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004236">
        <property type="entry name" value="Pept_S1_alpha_lytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001316">
        <property type="entry name" value="Pept_S1A_streptogrisin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035070">
        <property type="entry name" value="Streptogrisin_prodomain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018114">
        <property type="entry name" value="TRYPSIN_HIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033116">
        <property type="entry name" value="TRYPSIN_SER"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02983">
        <property type="entry name" value="Pro_Al_protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001134">
        <property type="entry name" value="Streptogrisin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00861">
        <property type="entry name" value="ALYTICPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="SSF50494"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00134">
        <property type="entry name" value="TRYPSIN_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00135">
        <property type="entry name" value="TRYPSIN_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 10" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014902913" evidence="7">
        <location>
            <begin position="39"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="domain" description="Pro_Al_protease" evidence="9">
        <location>
            <begin position="47"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S1" evidence="8">
        <location>
            <begin position="120"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="150"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="180"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="257"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="131"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="251"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR001134-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR001134-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PJN06626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="301" mass="30349" checksum="00C87EAB02C8939F" modified="2018-04-25" version="1">MRIKRTTPRSGIARRARMISVASGLVAIGALTVPTASASDAPVAHTFSATQLTQAGTSVLKSDVPGTAWTVDQKTNQVVVTADSTVSQAEIARIQKAAGSNAGALKIERTPGTFKKLVSGGDAIYASSWRCSLGFNVRSGSTYYFLTAGHCTDGAGTWWSNSSHSTTIGSTAGSSFPGNDYGLVRYSSTGTPPGTVGSQDITGAATPSVGTTVTRRGSTTGIHSGRVTALNATVNYGGGDIVSGLIQTTVCAEPGDSGGPLYGGSTAYGLTSGGSGNCTSGGTTFFQPVTEALSAYGVSVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-05-25" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JIB2</accession>
    <name>A0A2M9JIB2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Alcohol dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CG723_38565</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CB01635</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000028">
        <property type="protein sequence ID" value="PJN06621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN06621">
        <property type="protein sequence ID" value="PJN06621"/>
        <property type="gene ID" value="CG723_38565"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="PKS_ER"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="PKS_ER" evidence="3">
        <location>
            <begin position="14"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PJN06621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="346" mass="36503" checksum="009878BAD1B0F203" modified="2018-04-25" version="1">MTTVSAYAAPSAKAPLERTTIPRRPVSEFDVLIDIKFAGICHSDIHQARDGWGEGIFPMVPGHEIAGIVTEVGPGVTKFAVGDRVGVGCMVDSCRECDNCKAGLEQYCAKGNVGTYNALDKNGEPTYGGYSTHIVVDENYTVGIPEGLALDEAAPLLCAGITTYSPLKHWNAGPGKKVAVLGMGGLGHMGVKIAHALGAEVTVLSQSLRKQEDGLKLGADHYYATSDPKTFEELAGTFDIILSTVSAPLDFGAFLSLLKTDGALVNVGAPEEPISINLFSVIAGRKSLAGSGIGGIQETQEMLDFCAEHGLGAEIELIEASQINEAYERVLASDVRYRFVIDAATI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-09-29" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JIN3</accession>
    <name>A0A2M9JIN3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CG723_37325</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000026">
        <property type="protein sequence ID" value="PJN06745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN06745">
        <property type="protein sequence ID" value="PJN06745"/>
        <property type="gene ID" value="CG723_37325"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PJN06745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="349" mass="37043" checksum="CE7BD7AB1A7E5F8B" modified="2018-04-25" version="1">MPELLHTRAAGLVGRGGAAAALERLLREKRLVTVAGPGGVGKSALAAEVVRRMHREPWSAKGTADLATLDIPGLVPHALARALRLARDPAVPQLPALAAAIGRRPALLVVDTCERQAAECAATLLHLVQACPELRVIATSRVPLDTPVTFPLPPLAPDVAARLLRTAALALGAPRAPDPEPARRICAALGGLPLALRIAAGQLKGHDADDLLSLIGRPERLLDLPAPMPGLPHRLRTLRASLRWSQRLCPPGERLLWARASVFTGPFTLADTVTVCADDRLPPDELARAFEGLAAHCLITPEPSGPGAFRMTAATRAYGKHLLERLGEDAEFRRRCLAHCLHNAPALPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JJH5</accession>
    <name>A0A2M9JJH5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Carbohydrate kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_36595</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000024">
        <property type="protein sequence ID" value="PJN07002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN07002">
        <property type="protein sequence ID" value="PJN07002"/>
        <property type="gene ID" value="CG723_36595"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011611">
        <property type="entry name" value="PfkB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00294">
        <property type="entry name" value="PfkB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="SSF53613"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PfkB" evidence="1">
        <location>
            <begin position="7"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN07002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="305" mass="31801" checksum="93E85799F5C720E3" modified="2018-04-25" version="1">MTTTAATAVCLGETMAQVTPADGAGLERSEELRLAVAGAESTVAQYLADLGHGAAWVSRVGDDPFGRRIVAAVASRGVDVTGVRRDTSAPTGVYFKDPRPDGTRVHYYRAGSAASRMSAADADGIDLTDVRLLHLTGITPALSDTCAVLVAALLERAAGTKTLVSFDINHRPALWSSRGEAAEALLALARRADIVLVGRDEGETLWGTATAQDIRDHIAPRGTLVVKDGAVGATEFTDETQEFVAAPAVDVVEAVGAGDAFAAGYLSGLLDGAAPRQRLALGHRLAGRTLRSIEDYVPISPKDRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JJJ0</accession>
    <name>A0A2M9JJJ0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PPOX class F420-dependent oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_36630</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000024">
        <property type="protein sequence ID" value="PJN07022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN07022">
        <property type="protein sequence ID" value="PJN07022"/>
        <property type="gene ID" value="CG723_36630"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019967">
        <property type="entry name" value="F420-dep_enz_PPOX_Rv0121"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011576">
        <property type="entry name" value="Pyridox_Oxase_put"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01243">
        <property type="entry name" value="Putative_PNPOx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03668">
        <property type="entry name" value="Rv0121_F420"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Putative_PNPOx" evidence="1">
        <location>
            <begin position="4"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN07022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="141" mass="15769" checksum="840A7B47C0E94A7D" modified="2018-04-25" version="1">MAGDEARRRFMTARVARLATVDAGLRPHLVPVVFAAHGEEIVTAVDWKPKRSQQLKRLDNIAAHPAVCLLVDAYDEDWERLWWVRADGDARVLPPGTQGEYPAAVALLREKYAPYRQRPPTGPALVIAVRRWHGWRAASGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JJV3</accession>
    <name>A0A2M9JJV3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Protease inhibitor SIL-V5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CG723_34740</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CB01635</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protease inhibitor I16 (SSI) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000022">
        <property type="protein sequence ID" value="PJN07156.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN07156">
        <property type="protein sequence ID" value="PJN07156"/>
        <property type="gene ID" value="CG723_34740"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004867">
        <property type="term" value="F:serine-type endopeptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.350.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020054">
        <property type="entry name" value="Prot_inh_SSI_I16_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023549">
        <property type="entry name" value="Subtilisin_inhibitor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036819">
        <property type="entry name" value="Subtilisin_inhibitor-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00720">
        <property type="entry name" value="SSI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55399">
        <property type="entry name" value="SSF55399"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00999">
        <property type="entry name" value="SSI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0646">Protease inhibitor</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="5" id="KW-0722">Serine protease inhibitor</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014922448" evidence="7">
        <location>
            <begin position="23"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="domain" description="SSI" evidence="8">
        <location>
            <begin position="33"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00720"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PJN07156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="129" mass="13254" checksum="000E20A651A3F23A" modified="2018-04-25" version="1">MRPLVLAAAALTALAAAGPARATATDPPAPQGVFLTVSGDQGSWMRGELLRCEPGASGHHPHASEACAALDGAQGNLDALHPAPEMCTQVYAPVTVSASGTYRGKKITWEKTFANACTMNASTGSVFRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JK65</accession>
    <name>A0A2M9JK65_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Mannose-1-phosphate guanyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CG723_35365</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CB01635</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the phosphohexose mutase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000022">
        <property type="protein sequence ID" value="PJN07269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN07269">
        <property type="protein sequence ID" value="PJN07269"/>
        <property type="gene ID" value="CG723_35365"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016868">
        <property type="term" value="F:intramolecular transferase activity, phosphotransferases"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005844">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016055">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-I/II/III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005845">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005846">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036900">
        <property type="entry name" value="A-D-PHexomutase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001451">
        <property type="entry name" value="Hexapep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005835">
        <property type="entry name" value="NTP_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00132">
        <property type="entry name" value="Hexapep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00483">
        <property type="entry name" value="NTP_transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02878">
        <property type="entry name" value="PGM_PMM_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02879">
        <property type="entry name" value="PGM_PMM_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02880">
        <property type="entry name" value="PGM_PMM_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="SSF51161"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53738">
        <property type="entry name" value="SSF53738"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55957">
        <property type="entry name" value="SSF55957"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="NTP_transferase" evidence="2">
        <location>
            <begin position="2"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="domain" description="PGM_PMM_I" evidence="3">
        <location>
            <begin position="384"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="domain" description="PGM_PMM_II" evidence="4">
        <location>
            <begin position="532"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="domain" description="PGM_PMM_III" evidence="5">
        <location>
            <begin position="639"/>
            <end position="740"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PJN07269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="831" mass="89959" checksum="296C17122B1A84F5" modified="2018-04-25" version="1">MKAVVMAGGEGTRLRPMTSSMPKPLLPVVNRPIMEHVLRLLKRHGLTETVVTVQFLASLVRNYFGDGEELGMELTYANEEKPLGTAGSVKNAEEALKDDAFVVISGDALTDFDLTDLINFHKEKGALVTVCLTRVPNPLEFGITIVDEQGKVERFLEKPTWGQVFSDTVNTGIYVMEPEVFDYVEADVSVDWSGDVFPQLMKEGKPVYGYIAEGYWEDVGTHESYVKAQADVLEGKVDVEIDGFEISPGVWVAEGAEVHPDAVLRGPLYIGDYAKVEADVELREHTVIGSNVVVKSGAFLHKAVVHDNVYIGQHSNLRGCVIGKNTDIMRAARVEDGAVIGDECLVGEESIIQGNVRVYPFKTIEAGAFVNTSVIWESRGQAHLFGARGVSGIINVEITPELAVRLAGAYATTLKKGSTVTTARDHSRGARALKRAVISALQASAIDVRDLENVPLPVARQQTARGSAGGIMIRTTPGVPDSVDIMFFDERGADLSQASQRKLDRVYARQEYRRAFPGEIGDLHFPSSVFDSYTGSLLRNVDTTGIAEAGLKVVVDASNGSAGLVLPSLLGRLGVDSLTINPGLDESRPTETRDARRSGLVRLGEIVASARAAFGVRFDPVGERLSLVDEKGRIVEDDRALLVMLDLVAAERRSGRVALPVTTTRIAEQVAAYHGTQVEWTTTSPDDLTRVGRDEGTIFGGDGRGGFIIPEFSSVFDGAAAFVRLIGLVARTQLTLSQIDARIPRAHVLKRDLATPWAVKGLVMRRVVEEAGDRSVDTTDGVRVVEADGRWVMVLPDPAEAVTHLWAEGPDDASAQQLLDEWAAVVDSAGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JKC1</accession>
    <name>A0A2M9JKC1_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 10 11">Ribulose-phosphate 3-epimerase</fullName>
            <ecNumber evidence="7 10 11">5.1.3.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10 15" type="primary">rpe</name>
        <name evidence="15" type="ORF">CG723_34235</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">CB01635</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Catalyzes the reversible epimerization of D-ribulose 5-phosphate to D-xylulose 5-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10 11">
            <text>D-ribulose 5-phosphate = D-xylulose 5-phosphate</text>
            <dbReference type="Rhea" id="RHEA:13677"/>
            <dbReference type="ChEBI" id="CHEBI:57737"/>
            <dbReference type="ChEBI" id="CHEBI:58121"/>
            <dbReference type="EC" id="5.1.3.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10 13">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
        <text evidence="10 13">Binds 1 divalent metal cation per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="10">Carbohydrate degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6 10 11">Belongs to the ribulose-phosphate 3-epimerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.1.3.1" evidence="7 10 11"/>
    <dbReference type="EMBL" id="NNBL01000021">
        <property type="protein sequence ID" value="PJN07314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN07314">
        <property type="protein sequence ID" value="PJN07314"/>
        <property type="gene ID" value="CG723_34235"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00275">
        <property type="reaction ID" value="UER00400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004750">
        <property type="term" value="F:D-ribulose-phosphate 3-epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019323">
        <property type="term" value="P:pentose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006098">
        <property type="term" value="P:pentose-phosphate shunt"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00429">
        <property type="entry name" value="RPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02227">
        <property type="entry name" value="RPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026019">
        <property type="entry name" value="Ribul_P_3_epim"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000056">
        <property type="entry name" value="Ribul_P_3_epim-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011060">
        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11749">
        <property type="entry name" value="PTHR11749"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00834">
        <property type="entry name" value="Ribul_P_3_epim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001461">
        <property type="entry name" value="RPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51366">
        <property type="entry name" value="SSF51366"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01163">
        <property type="entry name" value="rpe"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01085">
        <property type="entry name" value="RIBUL_P_3_EPIMER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01086">
        <property type="entry name" value="RIBUL_P_3_EPIMER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 11" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="13" id="KW-0170">Cobalt</keyword>
    <keyword evidence="9 10 11" id="KW-0413">Isomerase</keyword>
    <keyword evidence="13" id="KW-0464">Manganese</keyword>
    <keyword evidence="8 10 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0862">Zinc</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="10 14">
        <location>
            <begin position="140"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="10">
        <location>
            <begin position="173"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="10 14">
        <location>
            <begin position="195"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="10 12">
        <location>
            <position position="33"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="10 12">
        <location>
            <position position="173"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10 14">
        <location>
            <position position="8"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10 13">
        <location>
            <position position="31"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10 13">
        <location>
            <position position="33"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10 13 14">
        <location>
            <position position="64"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10 13">
        <location>
            <position position="173"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="175"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00009541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00013188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR001461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR001461-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR001461-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR001461-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="PJN07314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="228" mass="24291" checksum="B96316140208BD51" modified="2018-04-25" version="1">MAVQINPSILSADFARLAEEAKAVEGADWLHVDVMDNHFVPNLTLGVPVVESLARATDIPLDCHLMIEDADRWAPQYVEAGAGSVTFHAEAAAAPIRLAREIRAKGARASMALKPATPIEPYEDLLPELDMLLIMTVEPGFGGQAFLDLMLPKIRRTRELISKHGLELWLQVDGGVSASTIERCAEAGADVFVAGSAVYGAADPAQAVRALRTQAETVSAAAAWACGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JKD9</accession>
    <name>A0A2M9JKD9_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 11">ATP phosphoribosyltransferase</fullName>
            <shortName evidence="11">ATP-PRT</shortName>
            <shortName evidence="11">ATP-PRTase</shortName>
            <ecNumber evidence="4 11">2.4.2.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">hisG</name>
        <name evidence="14" type="ORF">CG723_34350</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">CB01635</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10 11">Catalyzes the condensation of ATP and 5-phosphoribose 1-diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>1-(5-phospho-beta-D-ribosyl)-ATP + diphosphate = 5-phospho-alpha-D-ribose 1-diphosphate + ATP</text>
            <dbReference type="Rhea" id="RHEA:18473"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="ChEBI" id="CHEBI:73183"/>
            <dbReference type="EC" id="2.4.2.17"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="activity regulation">
        <text evidence="11">Feedback inhibited by histidine.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 11">Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 1/9.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the ATP phosphoribosyltransferase family. Long subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.17" evidence="4 11"/>
    <dbReference type="EMBL" id="NNBL01000021">
        <property type="protein sequence ID" value="PJN07335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN07335">
        <property type="protein sequence ID" value="PJN07335"/>
        <property type="gene ID" value="CG723_34350"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00031">
        <property type="reaction ID" value="UER00006"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003879">
        <property type="term" value="F:ATP phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00079">
        <property type="entry name" value="HisG_Long"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013820">
        <property type="entry name" value="ATP_PRibTrfase_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001348">
        <property type="entry name" value="ATP_PRibTrfase_HisG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020621">
        <property type="entry name" value="ATP_PRibTrfase_HisG_long"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013115">
        <property type="entry name" value="HisG_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011322">
        <property type="entry name" value="N-reg_PII-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015867">
        <property type="entry name" value="N-reg_PII/ATP_PRibTrfase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21403">
        <property type="entry name" value="PTHR21403"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01634">
        <property type="entry name" value="HisG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08029">
        <property type="entry name" value="HisG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54913">
        <property type="entry name" value="SSF54913"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00070">
        <property type="entry name" value="hisG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03455">
        <property type="entry name" value="HisG_C-term"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 11 14" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="9 11" id="KW-0368">Histidine biosynthesis</keyword>
    <keyword evidence="11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 11 14" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="HisG" evidence="12">
        <location>
            <begin position="49"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="domain" description="HisG_C" evidence="13">
        <location>
            <begin position="207"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00020998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00024861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF08029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="PJN07335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="282" mass="30150" checksum="D41759043783D221" modified="2018-04-25" version="1">MLRIAVPNKGSLSGPASAMLHEAGYQQRKESKELVLVDPVNEVEFFYLRPKDIAIYVSSGKLDIGITGEDLLIDSGVNAEVILPLGFARSTFRFAAKPGTVSGPGDLAGKTIATSYEGIVGKHLAESGVDASVVHLDGAVETAIELGVAQVIADVVETGTSLRNAGLEVFGEPIMKSEAVVIRRCGAAAEEPKVQQFLRRLQGVLVARTYVMMDYDCRAEHLEQAVALTPGLESPTVSPLHNEGWVAVRAMVPAKDAQRIMDDLYELGARAILTTAIHACRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JL94</accession>
    <name>A0A2M9JL94_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">6-phosphogluconate dehydrogenase (Decarboxylating)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">gnd</name>
        <name evidence="5" type="ORF">CG723_33220</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CB01635</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 6-phosphogluconate dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000019">
        <property type="protein sequence ID" value="PJN07628.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN07628">
        <property type="protein sequence ID" value="PJN07628"/>
        <property type="gene ID" value="CG723_33220"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004616">
        <property type="term" value="F:phosphogluconate dehydrogenase (decarboxylating) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019521">
        <property type="term" value="P:D-gluconate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016054">
        <property type="term" value="P:organic acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006098">
        <property type="term" value="P:pentose-phosphate shunt"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004849">
        <property type="entry name" value="6DGDH_YqeC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006114">
        <property type="entry name" value="6PGDH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006115">
        <property type="entry name" value="6PGDH_NADP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006184">
        <property type="entry name" value="6PGdom_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015815">
        <property type="entry name" value="HIBADH-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006183">
        <property type="entry name" value="Pgluconate_DH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11811">
        <property type="entry name" value="PTHR11811"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00393">
        <property type="entry name" value="6PGD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03446">
        <property type="entry name" value="NAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000103">
        <property type="entry name" value="HIBADH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00076">
        <property type="entry name" value="6PGDHDRGNASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01350">
        <property type="entry name" value="6PGD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="SSF48179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00872">
        <property type="entry name" value="gnd_rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00461">
        <property type="entry name" value="6PGD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0311">Gluconate utilization</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="6PGD" evidence="4">
        <location>
            <begin position="160"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008419"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000103-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM01350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PJN07628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="291" mass="31369" checksum="39095BD6DE2093A8" modified="2018-04-25" version="1">MELGLVGLGKMGGNMRERIRRAGHTVIGYDRNPDLADVHSLGELVGKLKAPRVVWVMVPAGGPTQATVDELADLLSPGDVVVDGGNSRWTDDEKHAVELGIKDIGFVDCGVSGGVWGLENGYALMYGGSKENVAKVQPIFDALKPEGEFGAVHAGKVGAGHFAKMVHNGIEYAMMQAYAEGWELLEKVDSVTDVREVFRSWQEGTVIRSWLLDLAVNALDDDEHLDKLRGFAADSGEGRWTVEAAIDNAVPLPAITASLFARFASRQDDSPQMKMIAALRNQFGGHAVEKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JLD3</accession>
    <name>A0A2M9JLD3_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8 10">Phosphatidylinositol phosphate synthase</fullName>
            <shortName evidence="10">PIP synthase</shortName>
            <ecNumber evidence="10">2.7.8.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9 10">CDP-diacylglycerol--D-myo-inositol-3-phosphate 3-phosphatidyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CG723_31940</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">CB01635</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Catalyzes the conjugation of the 1'-hydroxyl group of D-myo-inositol-3-phosphate (also named L-myo-inositol-1-phosphate) with a lipid tail of cytidine diphosphate diacylglycerol (CDP-DAG), forming phosphatidylinositol phosphate (PIP) and CMP. PIP is a precursor of phosphatidylinositol (PI) which is an essential lipid required for cell wall formation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 10">
            <text>1,2-di-(9Z-octadecenoyl)-sn-glycero-3-cytidine-5'-diphosphate + 1D-myo-inositol 3-phosphate = 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + CMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:61216"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58401"/>
            <dbReference type="ChEBI" id="CHEBI:60377"/>
            <dbReference type="ChEBI" id="CHEBI:85356"/>
            <dbReference type="ChEBI" id="CHEBI:144472"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7 10">
            <text>1D-myo-inositol 3-phosphate + a CDP-1,2-diacyl-sn-glycerol = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + CMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:60504"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58088"/>
            <dbReference type="ChEBI" id="CHEBI:58332"/>
            <dbReference type="ChEBI" id="CHEBI:58401"/>
            <dbReference type="ChEBI" id="CHEBI:60377"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="10">Contains a di-nuclear catalytic Mg(2+) center.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Lipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 10">Phospholipid metabolism; phosphatidylinositol phosphate biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5 10">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cell membrane</location>
            <topology evidence="10">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 10 11">Belongs to the CDP-alcohol phosphatidyltransferase class-I family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.8.-" evidence="10"/>
    <dbReference type="EMBL" id="NNBL01000018">
        <property type="protein sequence ID" value="PJN07690.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN07690">
        <property type="protein sequence ID" value="PJN07690"/>
        <property type="gene ID" value="CG723_31940"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00220"/>
    <dbReference type="UniPathway" id="UPA00705"/>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016780">
        <property type="term" value="F:phosphotransferase activity, for other substituted phosphate groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1760">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02241">
        <property type="entry name" value="PIP_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000462">
        <property type="entry name" value="CDP-OH_P_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043130">
        <property type="entry name" value="CDP-OH_PTrfase_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044268">
        <property type="entry name" value="PIP_synthase_PgsA1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01066">
        <property type="entry name" value="CDP-OH_P_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00379">
        <property type="entry name" value="CDP_ALCOHOL_P_TRANSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="10" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="10" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 11 12" id="KW-0808">Transferase</keyword>
    <keyword evidence="10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="177"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="region of interest" description="CDP-DAG binding" evidence="10">
        <location>
            <begin position="29"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="10">
        <location>
            <position position="91"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="66"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="69"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="70"/>
        </location>
        <ligand>
            <name>a CDP-1,2-diacyl-sn-glycerol</name>
            <dbReference type="ChEBI" id="CHEBI:58332"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="74"/>
        </location>
        <ligand>
            <name>a CDP-1,2-diacyl-sn-glycerol</name>
            <dbReference type="ChEBI" id="CHEBI:58332"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="80"/>
        </location>
        <ligand>
            <name>a CDP-1,2-diacyl-sn-glycerol</name>
            <dbReference type="ChEBI" id="CHEBI:58332"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="87"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="91"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00024082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00033137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PJN07690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="224" mass="23527" checksum="1590AFEC8F17335C" modified="2018-04-25" version="1">MLNKYARAFFTRVLTPFAAFLIRRGVSPDAVTLIGTAGVVAGALVFFPRGEFFWGTIVITLFVFSDLVDGNMARQLGRTSRWGAFLDSTLDRVADGAIFGGLALWYAGSGDNNMLCAVSIFCLASGQVVSYTKARGEAIGLPVAVNGLVERAERLVITLVAAGLAGLHKFGVPGIQIVLPIALWAVAAGSLVTLIQRMVTVRRESAEADAEGAAEASQESGTAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JLH2</accession>
    <name>A0A2M9JLH2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Chloride transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_32040</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000018">
        <property type="protein sequence ID" value="PJN07708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN07708">
        <property type="protein sequence ID" value="PJN07708"/>
        <property type="gene ID" value="CG723_32040"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044249">
        <property type="term" value="P:cellular biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005801">
        <property type="entry name" value="ADC_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019999">
        <property type="entry name" value="Anth_synth_I-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015890">
        <property type="entry name" value="Chorismate_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11236">
        <property type="entry name" value="PTHR11236"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00425">
        <property type="entry name" value="Chorismate_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00095">
        <property type="entry name" value="ANTSNTHASEI"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56322">
        <property type="entry name" value="SSF56322"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Chorismate_bind" evidence="1">
        <location>
            <begin position="83"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN07708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="351" mass="36964" checksum="4C6D2865DB64A961" modified="2018-04-25" version="1">MRDLPHDLPPLARFGGLVATELRDVTSDPEALDSAGFWAVSADFEGRLVCARFDSVREEPVPAPVPGAWQGPAAGDWTSSLDRAAYTEGVRSIRTHIAAGEVYQANLCRVLSAPLPPGADVDALTALLARGNPAPYAGTVRLPAHGVEIATASPELFLRRTGRTVESGPIKGTGRTEADLLEKDYAENVMIVDLVRNDLGRVCATGSVTVPELCVVEKHPGLVHLVSAVRGELPEGAGWRDLLDAAFPPGSVTGAPKSSALRIIGALETAPRGPYCGGIGWVDADRGTGELAVGIRTFWADRAEGVLRFGTGAGITWGSDPEGEWRETELKASRLLAVASGTYEESEGIPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-05-25" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JLS0</accession>
    <name>A0A2M9JLS0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">LacI family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CG723_32580</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000018">
        <property type="protein sequence ID" value="PJN07802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN07802">
        <property type="protein sequence ID" value="PJN07802"/>
        <property type="gene ID" value="CG723_32580"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01392">
        <property type="entry name" value="HTH_LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000843">
        <property type="entry name" value="HTH_LacI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046335">
        <property type="entry name" value="LacI/GalR-like_sensor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00356">
        <property type="entry name" value="LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13377">
        <property type="entry name" value="Peripla_BP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00354">
        <property type="entry name" value="HTH_LACI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50932">
        <property type="entry name" value="HTH_LACI_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH lacI-type" evidence="4">
        <location>
            <begin position="13"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PJN07802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="344" mass="35950" checksum="160ED3AB17C6968A" modified="2018-04-25" version="1">MTTGSDETAPARPTSRDVARAAGVSQAAVSLVLGDKWRGRVAEATAERVRTAARDLGYRPNLAARNLRLGRTRTALLVVPALTNEFFAGVYTGAARVAAQHGFGVVLYPSPEGIGPARDPFDSARAALDGVLASSMASDAVTAIRGDGLPLVMLDSDPDDTATTGAATVNLDIADGMRQVTDHLLALGHRRFLHLASAVPSWTFDVRAHELADRTARVPDTHVHTVHSHLTVEAARTAAQAALTAPGPRPTAIVCDDDKLATGAYKAARTLGLRIPDDLSVTGFDDLSLATAVEPELTTVRLPAELFGERGMAALLAVLDGRAPETTALPVELVVRGSTAAPAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JLS7</accession>
    <name>A0A2M9JLS7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alpha/beta hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_30960</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000017">
        <property type="protein sequence ID" value="PJN07830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN07830">
        <property type="protein sequence ID" value="PJN07830"/>
        <property type="gene ID" value="CG723_30960"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="7"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN07830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="228" mass="24690" checksum="9E7926EF86616F85" modified="2018-04-25" version="1">MASKPSIVFAHGLWADGSCFNKLIPTLQAEGHEVFASQHGLDSLESDVACVNFTLNHVPGPIVLVGHSYGGTLITKAGTHDRVGALVYIAALAPDEDETSQEHQDKFPRTPIFEHVDVADGRVWLKPSGVPHFCGDLPEAEQKLVLATGAVPVADLFNQQVPGTAWRTKPSWYIVANNDHTVHPDLERSAAERMAANIRPVDSSHVPMLSHPDFVLDVIREAAKSLDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-05-25" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JLZ7</accession>
    <name>A0A2M9JLZ7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">NAD(P)-dependent alcohol dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CG723_31325</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CB01635</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000017">
        <property type="protein sequence ID" value="PJN07885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN07885">
        <property type="protein sequence ID" value="PJN07885"/>
        <property type="gene ID" value="CG723_31325"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="PKS_ER"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014857721" evidence="4">
        <location>
            <begin position="19"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="domain" description="PKS_ER" evidence="5">
        <location>
            <begin position="79"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PJN07885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="423" mass="45331" checksum="6A6487190076863D" modified="2018-04-25" version="1">MRRTRRSTRAATPSRSCRATGRRRPRSASRPAEPGNSRAHPHSGSPGDAGLHPQRQGGTTREEIPPMKTMKGYVIQEKGRADWQKVPLPEIGPYDALVRPTAVATCTTDVHLIDSLALPNALGKVIGHEAVGVVEQVGDLVADFAAGDRVVLPAGLADWRHPRAQRGEGKFHQSKSPYFSDDPTNGGWFSEVVKCFDADSNLAHIPDGVTDVQAVFVDDMAATAFTGVERMEIQFGEVVVVLGVGPVGLMGVAAAALRGAGRIVAVDSRLDRMTLATQYGATDLIDYTQGDIYGQIMALTGGAHVDSVLVASGGSASDQITTAMRITKFGGHVSVVSGFFDDETVTLPMDVWNYGVMEKFLTAAQANQGRDYMERLLLLIANGKLDTQPLATHVLHGWDKVGASLELMRSRDQSVVKPVVIVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JM22</accession>
    <name>A0A2M9JM22_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">LLM class F420-dependent oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_31730</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000017">
        <property type="protein sequence ID" value="PJN07936.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN07936">
        <property type="protein sequence ID" value="PJN07936"/>
        <property type="gene ID" value="CG723_31730"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019945">
        <property type="entry name" value="F420_G6P_DH-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011251">
        <property type="entry name" value="Luciferase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036661">
        <property type="entry name" value="Luciferase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00296">
        <property type="entry name" value="Bac_luciferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51679">
        <property type="entry name" value="SSF51679"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03557">
        <property type="entry name" value="F420_G6P_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bac_luciferase" evidence="1">
        <location>
            <begin position="9"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN07936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="321" mass="34634" checksum="AD7A92D0DC8828EF" modified="2018-04-25" version="1">MVRFGYTMMTEQAGPRTLVDNVVAAERAGFEFSVTSDHYSPWLASQGHAPYAWSVLGAAAQATTRIQLMTFVTCPTIRYHPAVVAQKAATMQLLSEGRFRLGLGSGENLNEHVVGESWPSAGVRLDMLEEAVEIIRALFAGGELNHHGTHFDVVNAKLWDLPAQAPPVGIAVSGERSCSLAGRLADLVIATEPKAELLDAFDRHGGAGKPKIGQLPVCYDTDRHAAVLRAHDQFRWALGGWPVNAELPGPSGFEAATTYVTPDDVAKTIPCGDDVGAFADAVRPYIEAGFTEIALVQVGGDRQRPFIDWAEKHLLPALREL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JMI8</accession>
    <name>A0A2M9JMI8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Long-chain-fatty-acid--CoA ligase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_30895</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000016">
        <property type="protein sequence ID" value="PJN08089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08089">
        <property type="protein sequence ID" value="PJN08089"/>
        <property type="gene ID" value="CG723_30895"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-binding" evidence="1">
        <location>
            <begin position="11"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding_C" evidence="2">
        <location>
            <begin position="422"/>
            <end position="497"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN08089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="504" mass="54273" checksum="CB63C3586D561B72" modified="2018-04-25" version="1">MSFNLATMLYETASAAPDKPCVIIDDTALTYAQVEELSGLVAGNLLSLGLERGAKVAVQLPNIPQFLFAYFGALRAGLVMVPLNPLLRAPEVTYHLENSDAQVLITCESFAEEAHRGASAVPGISTYVVDLGGGQRPEGTRPFDELLAPAETPDIVPTNADDTAVLLYTSGTTGKPKGAELTHFQLYMNCSVAGDLIGFLDEDIVIAVLPMFHVFGLSSVLNAAVRFGTTMVLVPRFEPGAVIDAIERHGATIFPGVPTMYVALLNAAAGERDLASLRVGVSGGAAIPGEVIRAFEERFPGIVILEGYGLSETASTATFNISADQRKVLSVGKPVWGVQIRVVDTDDEPLPPGPDHVGEIVIRGHNVLKGYYKNPQATADAMRGGWFHTGDLGYADDDGYLFIVDRKKDLVIRGGYNVYPREVEEVLYEHPVVAEAAVIGRPDETFGEEVVAVVSLTPGRQATPEELIAFCKERMAAYKYPREIRVLHELPKGPTGKILKKELR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JMJ1</accession>
    <name>A0A2M9JMJ1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_30855</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000016">
        <property type="protein sequence ID" value="PJN08082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08082">
        <property type="protein sequence ID" value="PJN08082"/>
        <property type="gene ID" value="CG723_30855"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN08082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="104" mass="10842" checksum="15DE3859E4E7D742" modified="2018-04-25" version="1">MNVVAGAQRMTPTVPNPAAKGTAATTADEASARTLVVKWIEDGPGQAPTAHRRLRTELAALQFLGDDIGTGLAPDCCGAPPSGASATPYPCRAGRRNYCRRHGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JMQ9</accession>
    <name>A0A2M9JMQ9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DNA mismatch repair protein MutT</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CG723_29565</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CB01635</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the Nudix hydrolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000015">
        <property type="protein sequence ID" value="PJN08156.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08156">
        <property type="protein sequence ID" value="PJN08156"/>
        <property type="gene ID" value="CG723_29565"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020476">
        <property type="entry name" value="Nudix_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020084">
        <property type="entry name" value="NUDIX_hydrolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00502">
        <property type="entry name" value="NUDIXFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="SSF55811"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00893">
        <property type="entry name" value="NUDIX_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="4">
        <location>
            <begin position="3"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003476"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PJN08156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="131" mass="14472" checksum="F79044D36582918F" modified="2018-04-25" version="1">MTEPTVVVAAALHDSGRLLAARRSAPPELAGRWELPGGKVEPGEDPKQALVRELREELGIGAELVARVPGEWPLKPGYVLRVWTARPLSGRPRPLEDHDELRWLGPDEIWSVDWLDQDVPAVKAVLAARQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JMU2</accession>
    <name>A0A2M9JMU2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_29700</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000015">
        <property type="protein sequence ID" value="PJN08181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08181">
        <property type="protein sequence ID" value="PJN08181"/>
        <property type="gene ID" value="CG723_29700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="265"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="224"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN08181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="572" mass="56731" checksum="F1CDD4609EFA88AD" modified="2018-04-25" version="1">MDAGPATPDPAAAPVPAPETPAPPAPRTAPSGDGQGAPAAEEKTSDWFAPRKSGPPQRGGSADAPAPGNSGTVPGQSGGAAAPHGRPPQPGSSGDPHRGDLPYFAGNADGTGPGVPPRGPAGPTTGPVGGNSPMARPGGDNPMARPGGPVGGPPGGPMGGPVGGPLGGPAGGPPGGQRPPQMSDDTAILTPQKPAPEPGPGGHVSGETLTSGIPVVRPGLGGPNAPFAPGPRPEGPLPHTPPKLPDPVGQSAPAAPRKKKGRNKLVLVGAGVVGLVGVAYGAGLLMSHSDVPKGTTVLGVDIGGGTRDEAAAKLDTAFGKRTTDPLQLSVDGRSVPLRPDQAGLSLDSTATVAAAAGSDYNPVSVIGSLFGNERVVEPVMPVDEEKLRAALERAAGDASTGDGTIRFVPGKAIAVYGKTGKGIDVARSSSSVEEAYRAHVETGAARAVPMATTTRRPTVSNAEVDRMMKEFAQPAMSANVVIKAGNAQIPFGPAKSLPQILGVKAVNGKLVDVYDLPALKKLYGNTFDGILITRGTGKKTPVNPNDVAAAMRQALKGKTPAERTGTIETNPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JMY3</accession>
    <name>A0A2M9JMY3_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA helicase</fullName>
            <ecNumber evidence="3">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CG723_29990</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">CB01635</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O = ADP + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the helicase family. UvrD subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="3"/>
    <dbReference type="EMBL" id="NNBL01000015">
        <property type="protein sequence ID" value="PJN08233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08233">
        <property type="protein sequence ID" value="PJN08233"/>
        <property type="gene ID" value="CG723_29990"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004527">
        <property type="term" value="F:exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.320.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013986">
        <property type="entry name" value="DExx_box_DNA_helicase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014017">
        <property type="entry name" value="DNA_helicase_UvrD-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000212">
        <property type="entry name" value="DNA_helicase_UvrD/REP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011604">
        <property type="entry name" value="PDDEXK-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038726">
        <property type="entry name" value="PDDEXK_AddAB-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011335">
        <property type="entry name" value="Restrct_endonuc-II-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014016">
        <property type="entry name" value="UvrD-like_ATP-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11070">
        <property type="entry name" value="PTHR11070"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12705">
        <property type="entry name" value="PDDEXK_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00580">
        <property type="entry name" value="UvrD-helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13361">
        <property type="entry name" value="UvrD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52980">
        <property type="entry name" value="SSF52980"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51198">
        <property type="entry name" value="UVRD_HELICASE_ATP_BIND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51217">
        <property type="entry name" value="UVRD_HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0227">DNA damage</keyword>
    <keyword evidence="9" id="KW-0234">DNA repair</keyword>
    <keyword evidence="7" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="10 14" id="KW-0347">Helicase</keyword>
    <keyword evidence="10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UvrD-like helicase ATP-binding" evidence="12">
        <location>
            <begin position="36"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="domain" description="UvrD-like helicase C-terminal" evidence="13">
        <location>
            <begin position="346"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1037"/>
            <end position="1063"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="57"/>
            <end position="64"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="PJN08233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="1111" mass="120578" checksum="87AE09A453666AD4" modified="2018-04-25" version="1">MSSSSSTRNLSHRQVRQGIPGAYRLVRTPPAQVDPPRLDARQRAVVDHPHGPLLVLAGPGTGKTTTLVEAVAARIAKGTDPERILVLTFSRKAAVELRDRMALRIGAAHAPQATTFHSFCYALVRAHQDAGLFEEPLRLLSGPEQDVAVRELLAGQIDLEQAGLAHVRWPDELRACLTTRGFADEVRAVLARSRELGLGPAALDAFARRIGRPDWKAAATFLAEYLDVLDLHGVLDYAELVHRAVLLAHRTPVADELATRYDAVFVDEYQDTDPAQVRLLHALAGHGRTLLAFGDPDQSIYTFRGADVNGILEFPDQFPRADKSPAPVEVLTTSRRSGAHLLDATRRITRRMPLTRLPADKVRAHRELTPARDGGRVEVCTYPTSGTELDNIADILRRGHLEDGIPWGDMAVLVRAGTRSIPAIRRTLTAAGVPLDIDGDDLPLRHEPAVTPLLTALRAVALGVAQDIPEPDGDQDQEPPVWLDTETALTLLASPLAGMDAADLRRLGRALREEERAAGNHVPPPSDELLARALAQPERLAAHDPAHARGAQRLGALLRAARDTLTSGGTAEEALWQLWNGTSWPQRLERAARRGGAAGRNADRDLDAVCALFATASRAEERTGGRGALNFLEEVEAQDIAADTLAGRAVRPDAVRLMTAHRSKGLEWRLVVVAGVQEGLWPDLRRRGSLLEADRIGRDGLAEPLTPGALLSEERRLFYVATTRARERLVVTAVKAPADDGDQPSRFLTELGVDPQDVTGRPRRPLSVAALVAELRATTVDPRVSATLRDAAARRLARLAALTDDDGRPLVPSAHPYRWWGMDDPTESRIPLRDRDQPVVLSGSALDQLANTCSLQWFLGREVKADAPATAAQGFGNVVHVLADEVASGRTPADLAVLMERLDSVWDALAFDAPWKSVQEKEHARVALERFLRWHVDSSTVRTPVASEHAFDVTLEAGSYEVRIRGSMDRVERDTEGRAYVVDFKTGKQAPSAADVARHPQLAVYQLAVREGAVDEPFDGERPEPGGAELVQLRQGAAKKDGGDALPKVQSQHPLGDAADGGEGEWVGDLLATAAGKVLDERFTPTTGQHCTHCAFRASCSARPEGKHVVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JNC5</accession>
    <name>A0A2M9JNC5_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 13">Fructose-bisphosphate aldolase</fullName>
            <shortName evidence="13">FBP aldolase</shortName>
            <ecNumber evidence="5 13">4.1.2.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CG723_28685</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">CB01635</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 13">Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 13">
            <text>beta-D-fructose 1,6-bisphosphate = D-glyceraldehyde 3-phosphate + dihydroxyacetone phosphate</text>
            <dbReference type="Rhea" id="RHEA:14729"/>
            <dbReference type="ChEBI" id="CHEBI:32966"/>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="4.1.2.13"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12 13">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="12 13">Binds 2 Zn(2+) ions per subunit. One is catalytic and the other provides a structural contribution.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 13">Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 4/4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 13">Belongs to the class II fructose-bisphosphate aldolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.2.13" evidence="5 13"/>
    <dbReference type="EMBL" id="NNBL01000014">
        <property type="protein sequence ID" value="PJN08364.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08364">
        <property type="protein sequence ID" value="PJN08364"/>
        <property type="gene ID" value="CG723_28685"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00183"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004332">
        <property type="term" value="F:fructose-bisphosphate aldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000771">
        <property type="entry name" value="FBA_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006411">
        <property type="entry name" value="Fruct_bisP_bact"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30559">
        <property type="entry name" value="PTHR30559"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01116">
        <property type="entry name" value="F_bP_aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001359">
        <property type="entry name" value="F_bP_aldolase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00167">
        <property type="entry name" value="cbbA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01520">
        <property type="entry name" value="FruBisAldo_II_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00602">
        <property type="entry name" value="ALDOLASE_CLASS_II_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="9 13" id="KW-0456">Lyase</keyword>
    <keyword evidence="7 12 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 12 13" id="KW-0862">Zinc</keyword>
    <feature type="region of interest" description="Dihydroxyacetone phosphate binding" evidence="11">
        <location>
            <begin position="253"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="region of interest" description="Dihydroxyacetone phosphate binding" evidence="11">
        <location>
            <begin position="274"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="10">
        <location>
            <position position="95"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="96"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="131"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="161"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="212"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="213"/>
        </location>
        <ligand>
            <name>dihydroxyacetone phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="252"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00013779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR001359-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR001359-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR001359-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU366023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="PJN08364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="343" mass="36725" checksum="2E0B2C018EACC791" modified="2018-04-25" version="1">MPIATPEVYAEMLDRAKAGKFAYPAINVTSSQTLNAALRGFAEAESDGIIQISTGGAEFLGGQYNKDMVTGAVALAEYAHIIAEKYDVTVALHTDHCPKGKLDGYVRPLLDISAERVKAGRNPLFQSHMWDGSAETLADNLAIGQELLAKAAAAKIILEVEITPTGGEEDGVSHEINDELYTTVDDAIRTAEALGLGEKGRYLLAASFGNVHGVYKPGNVVLRPELLKDLQEGVGAKYGKTAGSQPFDFVFHGGSGSTEQEIATALENGVVKMNLDTDTQYAFTRPVADHMFRHYDGVLKVDGEVGVKSQYDPRTWGKSAEAGMAKRVSEACANLRSTGTKLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JNF3</accession>
    <name>A0A2M9JNF3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_28855</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000014">
        <property type="protein sequence ID" value="PJN08395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08395">
        <property type="protein sequence ID" value="PJN08395"/>
        <property type="gene ID" value="CG723_28855"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013517">
        <property type="entry name" value="FG-GAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028994">
        <property type="entry name" value="Integrin_alpha_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01839">
        <property type="entry name" value="FG-GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69318">
        <property type="entry name" value="SSF69318"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN08395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="130" mass="13294" checksum="3C1B2A4864059C63" modified="2018-04-25" version="1">MRLRTITALTALVAAALGDGYQDLAVGAYGEKIDDKEYAGGVRVFKGRAAGISGTGSQWFARNSPGVTGALDSDDSFGSAVRLRDTDRDGYADLYVAGTVGSLRLPGSASGITTTGAASVPSDLIEGFLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-09-29" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JNJ2</accession>
    <name>A0A2M9JNJ2_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Uma2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_29115</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000014">
        <property type="protein sequence ID" value="PJN08436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08436">
        <property type="protein sequence ID" value="PJN08436"/>
        <property type="gene ID" value="CG723_29115"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06260">
        <property type="entry name" value="DUF820"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1570.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012296">
        <property type="entry name" value="Nuclease_put_TT1808"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011335">
        <property type="entry name" value="Restrct_endonuc-II-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008538">
        <property type="entry name" value="Uma2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05685">
        <property type="entry name" value="Uma2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52980">
        <property type="entry name" value="SSF52980"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Uma2" evidence="2">
        <location>
            <begin position="34"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN08436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="208" mass="23596" checksum="87577F9E7BAED6D2" modified="2018-04-25" version="1">MGGTMTAEALPEASQPRRDDSKWPVPPPDGYTVDDFFTLDDLPPHTELIDGSLVFVSPQRKFHTLAMDLLVNGLRRTIPEHLRVRREMAVVLGPRQAPEPDLLVVDAEADGDRRQTRYEAADVLLAVEVVSPDSEDRDRDTKPRKYAKAGIRHFWLVEMAGEQDRPMVVTYELDPVNRTYVSTGVHHDRLKLSAPYDIDIDLTEIDRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JNP0</accession>
    <name>A0A2M9JNP0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">RdlA protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_28340</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000014">
        <property type="protein sequence ID" value="PJN08483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08483">
        <property type="protein sequence ID" value="PJN08483"/>
        <property type="gene ID" value="CG723_28340"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014948606" evidence="1">
        <location>
            <begin position="29"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN08483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="136" mass="13508" checksum="01798EFA4FA1C097" modified="2018-04-25" version="1">MMKKVMAAAAVAASVAGISAVAAPQAMAIGNDGGTTSNSGNGASQVYGNSATYGKMSPQMALIQGSLNKPCIALPVKGNAGGVAGVVPVGIHDIPILSAPQNQQCVENSTQAKGDEPLSHILDDFPILSGNGAHNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JNZ5</accession>
    <name>A0A2M9JNZ5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ABC transporter substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_27435</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000013">
        <property type="protein sequence ID" value="PJN08517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08517">
        <property type="protein sequence ID" value="PJN08517"/>
        <property type="gene ID" value="CG723_27435"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042597">
        <property type="term" value="C:periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030678">
        <property type="entry name" value="Peptide/Ni-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039424">
        <property type="entry name" value="SBP_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000914">
        <property type="entry name" value="SBP_5_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30290">
        <property type="entry name" value="PTHR30290"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00496">
        <property type="entry name" value="SBP_bac_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002741">
        <property type="entry name" value="MppA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014598675" evidence="1">
        <location>
            <begin position="21"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="domain" description="SBP_bac_5" evidence="2">
        <location>
            <begin position="92"/>
            <end position="404"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN08517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="513" mass="54892" checksum="799DE8512B04A64A" modified="2018-04-25" version="1">MSRVNGVGRRRFLQWGAAAATATAGATALSGCATSKSGDTRSVGSAGKLLRVGASDATGTTSLDPRHAGFGASYIALYHLYDQLMYLKGSRYELGLAESVEPDKDAGEWTIRLHKHAVFHDGSPVRAADVAYSLRTLATPPSTRANNFVDLDLDRLKAVDAHTLKVGLKRPRGDFREAVLAVFSPVFPEGTRGKDFDKGVGSGPYRLEEHDGKNLRLAVNDKYWGGTSYFRRIELDLIADPAARLAALKSGQIDYAFGITATGAKAERGNSAIRVRRGGTANSNALSFAMNEQLAPFDNPDVRRAVRLAADREALVRQVLLGLGTKGDDVVGKGLPGYAGGDRKRDLAEARRLFARAKVDSLTLHAADTVPGFVAAARLLGQQLQEAGVELDVQKVPADTYYADLKGLARTPFQTFYYANRPAAVHLSATTTKGAFFNVTGLGEPHFKRLASAQATVDDSKREAAFAAVQRGLYSSGGDLLWGFQEQLDASAPGLSGVWSSQSIPVFTRARSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JQ88</accession>
    <name>A0A2M9JQ88_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">acidPPc domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CG723_24235</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000010">
        <property type="protein sequence ID" value="PJN09043.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN09043">
        <property type="protein sequence ID" value="PJN09043"/>
        <property type="gene ID" value="CG723_24235"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036938">
        <property type="entry name" value="P_Acid_Pase_2/haloperoxi_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000326">
        <property type="entry name" value="P_Acid_Pase_2/haloperoxidase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01569">
        <property type="entry name" value="PAP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00014">
        <property type="entry name" value="acidPPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48317">
        <property type="entry name" value="SSF48317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="38"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="75"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="122"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="148"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="174"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="domain" description="acidPPc" evidence="3">
        <location>
            <begin position="76"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="219"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="224"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PJN09043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="239" mass="25182" checksum="7D4836C32CCF0221" modified="2018-04-25" version="1">MAGLAGLSALGASGSNPDVGLLYDINGLAKDAPGWVDSAMAFVGEYGLLLALVLLTLWCWWGVRKRDSLDDAASSVASVVWAPLAAGIAVLVNVPIRSFVERPRPFTDHEGLDVLVDGKSDFSFVSDHATLAMAIGAGLFVAHRKFGLIGLGLAVLEGFCRVFMGVHYPTDVVGGFALGTAVALLLSPLASALLTPLARSVGRTTRLRWLVWSPSPASSARETVEIPEPRESEERDLAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JQP1</accession>
    <name>A0A2M9JQP1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MarR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_25025</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000010">
        <property type="protein sequence ID" value="PJN09175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN09175">
        <property type="protein sequence ID" value="PJN09175"/>
        <property type="gene ID" value="CG723_25025"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000835">
        <property type="entry name" value="HTH_MarR-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12802">
        <property type="entry name" value="MarR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00347">
        <property type="entry name" value="HTH_MARR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50995">
        <property type="entry name" value="HTH_MARR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH marR-type" evidence="1">
        <location>
            <begin position="26"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN09175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="169" mass="17829" checksum="0D05A68CBE7EF677" modified="2018-04-25" version="1">MSDDAAEPDESPSGCPSAGAGLLPPELRAWMLLLAATGGVEQRLRSVVKEQLGVSHDEFLILCLLAEEKGESTEGGVRMTRIADLLGRPKTRLTYQVALLQRAGLVTRASACGDKRGVEVALTDKARTLLRQASAALAATVTDAIAQFVGAAQQEALHSLIPSPEEARN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-09-29" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JQZ9</accession>
    <name>A0A2M9JQZ9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Integrase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_23470</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000009">
        <property type="protein sequence ID" value="PJN09309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN09309">
        <property type="protein sequence ID" value="PJN09309"/>
        <property type="gene ID" value="CG723_23470"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13683">
        <property type="entry name" value="rve_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="1">
        <location>
            <begin position="1"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN09309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="133" mass="15634" checksum="FD979ACE3F602481" modified="2018-04-25" version="1">MDCQGAGIRGKFLIRDRDAKYPALIDEILADAGIRTAFTGARKPRMNSITERWVRTLRRELLDRTLIWNQQHLRHALRAYELHDNEHRTHRSLQTTAPLHPLPQPLEPERIPSLRIRRHDRLGGVLREYRHAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JR46</accession>
    <name>A0A2M9JR46_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glyoxalase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_23785</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000009">
        <property type="protein sequence ID" value="PJN09356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN09356">
        <property type="protein sequence ID" value="PJN09356"/>
        <property type="gene ID" value="CG723_23785"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004360">
        <property type="entry name" value="Glyas_Fos-R_dOase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00903">
        <property type="entry name" value="Glyoxalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VOC" evidence="1">
        <location>
            <begin position="12"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN09356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="150" mass="16120" checksum="A89EF5649783B553" modified="2018-04-25" version="1">MHGDGFPAPDSGLLLTHFLTVTDVARSRAFYADVLGGEVVLEENPCTIKLANGWIIMNPGGGPTPDKPDVILRPPTDPSTVSSFLNLRVADIEACHREWSAKGAEFLTPPIDRKAELRCYLRDPDGYLIEVGQATGMLQGVYADPPAGTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JR56</accession>
    <name>A0A2M9JR56_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_23865</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000009">
        <property type="protein sequence ID" value="PJN09366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN09366">
        <property type="protein sequence ID" value="PJN09366"/>
        <property type="gene ID" value="CG723_23865"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015006592" evidence="2">
        <location>
            <begin position="34"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="145"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="177"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="206"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="236"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="295"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN09366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="345" mass="34454" checksum="B1D42085C96E6EE1" modified="2018-04-25" version="1">MTHHATPPGTGRKLTLVVLALAALIAAMLCAFALPSLHSGAHHVPIGVTGPGQAAETVRGTVDGPEWDVRVYETPEAVETAVKGGDIAGGLAITAQGVDVYAATASGPSATSALTALGDGVAEQNKTQATVHDVVPFTDDDPRGAGLTAALMPMIFAGIFPALILGNVFPGHRGLRVRLAGALTFSVVAGAAVAAVLQFGTHSIDGSFGLTALGVILGMAALSTTLLGLQARFGMAGFAIGGALMMLLGNPLSGLATGPHWLPDGWATIGQLLPPGASGSLLRANAFFDGAGSGLPGLVLMVWVVIGVGLALLADRRGRRAAGSRSKVIAASATVDASHAEFATS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JR93</accession>
    <name>A0A2M9JR93_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_24035</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000009">
        <property type="protein sequence ID" value="PJN09396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN09396">
        <property type="protein sequence ID" value="PJN09396"/>
        <property type="gene ID" value="CG723_24035"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="72"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="233"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="288"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN09396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="335" mass="35571" checksum="14F04E644041FDA8" modified="2018-04-25" version="1">MTGILGDFGAQLGKGLADKWLSLLALPGALYLAVCAAAQALGQAHALDAPRLAHQVTTWAHAPAVRTTGGQIVVLVAVLAASVAAGLAARALGAGIERVALAADWRSWPRPAAALARRRTDIRRRRWDAAHREYSAQWARAARAAALDREVDPTARRRALGARAAISAERPDRPTWSGDRVHAVALRLQRDQHLDLGQLWPYIWLSLPEGERTELVATRSAGARAAELGAWSVLYAALAAVWWPAGVLAVLLAATARRRARSTTDSYARLVEAVVRLHSRELMERFGIEDAGPPSSGDRLGDALGSAPPVVVNVAEPGGSVDPASRDESGGGRRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JRG4</accession>
    <name>A0A2M9JRG4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">3-hydroxyacyl-CoA dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_21995</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000008">
        <property type="protein sequence ID" value="PJN09453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN09453">
        <property type="protein sequence ID" value="PJN09453"/>
        <property type="gene ID" value="CG723_21995"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000033">
        <property type="entry name" value="LDLR_classB_rpt"/>
    </dbReference>
    <dbReference type="SMART" id="SM00135">
        <property type="entry name" value="LY"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="210"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN09453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="300" mass="32552" checksum="956F09CD1C627C77" modified="2018-04-25" version="1">MTQRQERLFVLELSGGGRVFSVNPDGTDKKVIVTGCRYPDGVAVDVEAGHLYWTNMGSPPVNDGSIERVGLDGSNRTTIVPSGGTHTPKQLHFEAVGRKLYWGDREGMRVMRCDLDGSNVETLVQTGQGGNDRRDPTRWCVGVAVDPGGGHLYWTQKGPSDAGLGKILRAGIDLPAGESAADRSDIEVLLRGLPEPIDLQLDLAERTLYWTDRGDPPRGNSVNRTPMDPQNGQREAEILWTHLMEGIGIALDLDGSRMFVTDMAGTVYAADLDGSNRREILIVQGNLTGIAHALIPTEEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JRI8</accession>
    <name>A0A2M9JRI8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">B/F/G family RNA polymerase sigma-70 factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CG723_22210</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000008">
        <property type="protein sequence ID" value="PJN09483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN09483">
        <property type="protein sequence ID" value="PJN09483"/>
        <property type="gene ID" value="CG723_22210"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014322">
        <property type="entry name" value="RNA_pol_sigma-B/F/G"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000943">
        <property type="entry name" value="RNA_pol_sigma70"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007624">
        <property type="entry name" value="RNA_pol_sigma70_r3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007630">
        <property type="entry name" value="RNA_pol_sigma70_r4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04539">
        <property type="entry name" value="Sigma70_r3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04545">
        <property type="entry name" value="Sigma70_r4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00046">
        <property type="entry name" value="SIGMA70FCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02980">
        <property type="entry name" value="SigBFG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00715">
        <property type="entry name" value="SIGMA70_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0731">Sigma factor</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="RNA_pol_sigma70" evidence="5">
        <location>
            <begin position="88"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS00715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PJN09483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="287" mass="32462" checksum="ECB8680B07B1368A" modified="2018-04-25" version="1">MITVTTQEKIQAAQAQEDLVERAYADPSSIAPKDAREIGKRFFGRLGQLEEGTHEYQYVRNCLIEMNLSLVRYAASRFRHRGQEEMEDIVQVGTIGLIKAIDRFELTREVEFATFAVPYITGEIKRFFRDTSWAVHVPRRLQEARIELSKATEELRTRLGRNPSTAELAELMQLEPSEVTQAQMASNGYNASSLDASVMSAGDESDTALADFIGFEEDSYELIDNFHSLAPLIADLDERERTLIHLRFVEEQTQSQIGEALGVSQMHVSRLITRVVAKLRTGLMTTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JRW3</accession>
    <name>A0A2M9JRW3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">LysR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_23055</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000008">
        <property type="protein sequence ID" value="PJN09609.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN09609">
        <property type="protein sequence ID" value="PJN09609"/>
        <property type="gene ID" value="CG723_23055"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016040">
        <property type="entry name" value="NAD(P)-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13460">
        <property type="entry name" value="NAD_binding_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD(P)-bd_dom" evidence="1">
        <location>
            <begin position="7"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN09609.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="242" mass="25410" checksum="4F4967A77727173B" modified="2018-04-25" version="1">MKFAVIGGTGLIGSQVVKDLNAAGHQAVPHSKSTGVDVLTGQGLDEAVAGADVVINLTNSPTFDEASPAFFQTSMDNLLAAAHKGGVGHFVILSIVGTDQVPELDYYRAKTLQEHILANGPVPFSIVRATQFMEFMDAVMSWTADGDTIRLPATPIQPIAAKDVAGAVAEVAAGTPLNGIRNIAGPEIFPLDELGRITLSRKDDSRTVVTDPTAGMFAVVSGDVLTDKDAHLAPTRYTDWLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JS93</accession>
    <name>A0A2M9JS93_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glyoxalase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_21420</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000007">
        <property type="protein sequence ID" value="PJN09761.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN09761">
        <property type="protein sequence ID" value="PJN09761"/>
        <property type="gene ID" value="CG723_21420"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004360">
        <property type="entry name" value="Glyas_Fos-R_dOase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00903">
        <property type="entry name" value="Glyoxalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VOC" evidence="1">
        <location>
            <begin position="4"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN09761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="135" mass="15008" checksum="A8926B22057E79C4" modified="2018-04-25" version="1">MYQQMIFPNLAVNDLDASKKFFTELGYSINPQFSDETCASVVVSEHIVVMLLTKEKYAGFTKKTIVDSTKSTEVLLCLSAESREKVDELVDKAIAAGGTETGEKQDHGFMYGRAFDDPDGHTWEIMWMDPAAVQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JSX3</accession>
    <name>A0A2M9JSX3_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Succinate--CoA ligase [ADP-forming] subunit alpha</fullName>
            <ecNumber evidence="2">6.2.1.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Succinyl-CoA synthetase subunit alpha</fullName>
            <shortName evidence="2">SCS-alpha</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2" type="primary">sucD</name>
        <name evidence="7" type="ORF">CG723_19790</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CB01635</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 5">Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 5">
            <text>ATP + CoA + succinate = ADP + phosphate + succinyl-CoA</text>
            <dbReference type="Rhea" id="RHEA:17661"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57292"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.2.1.5"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 5">Carbohydrate metabolism; tricarboxylic acid cycle; succinate from succinyl-CoA (ligase route): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2 5">Heterotetramer of two alpha and two beta subunits.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the succinate/malate CoA ligase alpha subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.2.1.5" evidence="2"/>
    <dbReference type="EMBL" id="NNBL01000006">
        <property type="protein sequence ID" value="PJN09970.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN09970">
        <property type="protein sequence ID" value="PJN09970"/>
        <property type="gene ID" value="CG723_19790"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00223">
        <property type="reaction ID" value="UER00999"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004775">
        <property type="term" value="F:succinate-CoA ligase (ADP-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.261">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01988">
        <property type="entry name" value="Succ_CoA_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017440">
        <property type="entry name" value="Cit_synth/succinyl-CoA_lig_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033847">
        <property type="entry name" value="Citrt_syn/SCS-alpha_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003781">
        <property type="entry name" value="CoA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005810">
        <property type="entry name" value="CoA_lig_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005811">
        <property type="entry name" value="CoA_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016102">
        <property type="entry name" value="Succinyl-CoA_synth-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02629">
        <property type="entry name" value="CoA_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00549">
        <property type="entry name" value="Ligase_CoA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001553">
        <property type="entry name" value="SucCS_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00881">
        <property type="entry name" value="CoA_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52210">
        <property type="entry name" value="SSF52210"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01019">
        <property type="entry name" value="sucCoAalpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01216">
        <property type="entry name" value="SUCCINYL_COA_LIG_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00399">
        <property type="entry name" value="SUCCINYL_COA_LIG_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4 7" id="KW-0436">Ligase</keyword>
    <keyword evidence="1 2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="CoA_binding" evidence="6">
        <location>
            <begin position="4"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Coenzyme A binding" evidence="2">
        <location>
            <begin position="17"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Coenzyme A binding" evidence="2">
        <location>
            <begin position="100"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="active site" description="Tele-phosphohistidine intermediate" evidence="2 3">
        <location>
            <position position="251"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="43"/>
        </location>
        <ligand>
            <name>CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="165"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared with subunit beta</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR001553-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PJN09970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="293" mass="30055" checksum="24D6C598BE362E6D" modified="2018-04-25" version="1">MAIFLTKDSKVIVQGMTGATGMKHTKLMLGDGTNIVGGVNPRKAGTSVDFDGTEVPVFGTVKEAMEKTGANVSVLFVPPAFSKAAVVEAIDAEIPLAVVITEGIAVHDSAAFWAYAKSKGNKTRIIGPNCPGLITPGQSNAGIIPGDITKPGRIGLVSKSGTLTYQMMYELRDLGFSSAVGIGGDPVIGTTHIDALEAFEADPDTDLIVMIGEIGGDAEERAADYIAKHVTKPVVGYVAGFTAPEGKTMGHAGAIVSGSSGTAQAKKEALEAAGVKVGKTPTETAKLARELLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JTB0</accession>
    <name>A0A2M9JTB0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">PRL2-8</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CG723_20650</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000006">
        <property type="protein sequence ID" value="PJN10114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN10114">
        <property type="protein sequence ID" value="PJN10114"/>
        <property type="gene ID" value="CG723_20650"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PJN10114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="41" mass="4699" checksum="80E2680ACC7A50C8" modified="2018-04-25" version="1">MSAQCWEHAYNRAVHRRLGPREDCPQCVDHMVNGCPGFNRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JTZ9</accession>
    <name>A0A2M9JTZ9_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Cyanate hydratase</fullName>
            <shortName evidence="3">Cyanase</shortName>
            <ecNumber evidence="3">4.2.1.104</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Cyanate hydrolase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="3">Cyanate lyase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3 5" type="primary">cynS</name>
        <name evidence="5" type="ORF">CG723_18410</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CB01635</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 3">Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>cyanate + 3 H(+) + hydrogencarbonate = 2 CO2 + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:11120"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29195"/>
            <dbReference type="EC" id="4.2.1.104"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the cyanase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.104" evidence="3"/>
    <dbReference type="EMBL" id="NNBL01000005">
        <property type="protein sequence ID" value="PJN10349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN10349">
        <property type="protein sequence ID" value="PJN10349"/>
        <property type="gene ID" value="CG723_18410"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008824">
        <property type="term" value="F:cyanate hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009439">
        <property type="term" value="P:cyanate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00559">
        <property type="entry name" value="Cyanase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1160.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00535">
        <property type="entry name" value="Cyanate_hydrat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008076">
        <property type="entry name" value="Cyanase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003712">
        <property type="entry name" value="Cyanate_lyase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036581">
        <property type="entry name" value="Cyanate_lyase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34186">
        <property type="entry name" value="PTHR34186"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02560">
        <property type="entry name" value="Cyanate_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001263">
        <property type="entry name" value="Cyanate_hydratas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01693">
        <property type="entry name" value="CYANASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01116">
        <property type="entry name" value="Cyanate_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55234">
        <property type="entry name" value="SSF55234"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00673">
        <property type="entry name" value="cynS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0456">Lyase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyanate_lyase" evidence="4">
        <location>
            <begin position="83"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="96"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="99"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM01116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PJN10349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="156" mass="16630" checksum="8CBDE760C2F11785" modified="2018-04-25" version="1">MPHAQFDPTARETLAVAAVAAKTRKDLTWQRIADAAGLSPAFVTAAVLGQHALPKTSAEAVAELLGLDEDAALLLQTIPTRGSIPGGIPTDPTIYRFHEMLQVYGTTLKALVHEQFGDGIISAINFKLDVKKVADPEGGERAVITLDGKYLPTKPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JU24</accession>
    <name>A0A2M9JU24_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Flavin-dependent monooxygenase</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">TetX monooxygenase</fullName>
            <shortName evidence="1">TetX</shortName>
            <ecNumber evidence="1">1.14.13.-</ecNumber>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CG723_18720</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CB01635</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">An FAD-requiring monooxygenase active on some tetracycline antibiotic derivatives, which leads to their inactivation. Hydroxylates carbon 11a of tetracycline and some analogs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a tetracycline + H(+) + NADPH + O2 = an 11a-hydroxytetracycline + H2O + NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:61444"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:144644"/>
            <dbReference type="ChEBI" id="CHEBI:144645"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="1">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="1">Consists of an N-terminal FAD-binding domain with a Rossman fold and a C-terminal substrate-binding domain.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the aromatic-ring hydroxylase family. TetX subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.13.-" evidence="1"/>
    <dbReference type="EMBL" id="NNBL01000005">
        <property type="protein sequence ID" value="PJN10396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN10396">
        <property type="protein sequence ID" value="PJN10396"/>
        <property type="gene ID" value="CG723_18720"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046677">
        <property type="term" value="P:response to antibiotic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00845">
        <property type="entry name" value="TetX_monooxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043683">
        <property type="entry name" value="TetX_monooxygenase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1" id="KW-0274">FAD</keyword>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="1" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="1" id="KW-0521">NADP</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD_binding_3" evidence="3">
        <location>
            <begin position="8"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="385"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="385"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="43"/>
        </location>
        <ligand>
            <name>NADPH</name>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="50"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="107"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="301"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PJN10396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="412" mass="42911" checksum="E69663558BC6494D" modified="2018-04-25" version="1">MTTTHHSIAIVGGGLGGLVLARVLHLGGVEAAVYDLEASAAARPQGGMLDMHVESGQAALRAAGLHEEFVAAIHAGGESMRILDQHGTVRMEESDNGGTDGRPEVNRHDLRDMLLASLPEGTIRWGAKVTGARPLTGGRHEVTLASGETFTTDLLVGADGAWSKVRPLLSDARPAYSGISFVEAYLDDADTLHPESAAVVGGGALFALGDEKGFLTHRESDGRIHVYCALRVPSDWFTTSGIDFADTEAAKARILTSFDGWDEALRGLIGDADGALVPRSIHALPVGHRWDRVPGVTLLGDAAHLMSPFAGEGANLAMLDGAELAAAILAHPGETEKALAVYEEALFPRSEHAAAGSADNLDVIFSPDAPQGLLDMFASFREKAEAAGDEAETAGEKAETMGDAAETVGTGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JU89</accession>
    <name>A0A2M9JU89_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">TetR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CG723_19035</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000005">
        <property type="protein sequence ID" value="PJN10450.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN10450">
        <property type="protein sequence ID" value="PJN10450"/>
        <property type="gene ID" value="CG723_19035"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023772">
        <property type="entry name" value="DNA-bd_HTH_TetR-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041347">
        <property type="entry name" value="MftR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17754">
        <property type="entry name" value="TetR_C_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01081">
        <property type="entry name" value="HTH_TETR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="3">
        <location>
            <begin position="25"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="48"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PJN10450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="224" mass="24036" checksum="D54943E0AAB8102A" modified="2018-04-25" version="1">MTSGTATSAVREQAPAEGLRARRRRQTRAELHAATVRLAREHGLEHVTVEMISKEAGVSPRTFFNYFRTKETALFAWPGGLTEAEAEQFVSAPGRDPDAVLRDLGEVFATHVDEMAPGAGAFEDVFAIVEKVPSALGAFLAECDALERDLAGAIARRTGDAPDGQTVALLAGIAMTAVRNGLMRWARDKQHPDGPAASVRDSFTALRGLLSPADFPHATTEREA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JUA5</accession>
    <name>A0A2M9JUA5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CG723_19150</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000005">
        <property type="protein sequence ID" value="PJN10471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN10471">
        <property type="protein sequence ID" value="PJN10471"/>
        <property type="gene ID" value="CG723_19150"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PJN10471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="166" mass="17982" checksum="42322119008CC360" modified="2018-04-25" version="1">MSFLRRRSSATPAGPDFDVLAMDPGDWPGNLGAGLLPAPDGSCQGVFLRYDLFGGRGPAMIIGNLPEGSSARETAEGEIPFEVAQLLLALENDEEVTVVGTEDVPVMQGDNLLIVRRLKLSESRISCVQFDRSDNVLVTIAAWDRPITDDLYALLKPLPPELFQQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-09-29" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JUB7</accession>
    <name>A0A2M9JUB7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CG723_18340</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CB01635</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000005">
        <property type="protein sequence ID" value="PJN10496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN10496">
        <property type="protein sequence ID" value="PJN10496"/>
        <property type="gene ID" value="CG723_18340"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="34"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="63"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="88"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="121"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="151"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="192"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="218"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="255"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="289"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="319"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="342"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="382"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="414"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="1"/>
            <end position="438"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PJN10496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="445" mass="46105" checksum="0949413B3A086C2A" modified="2018-04-25" version="1">MILGSVLNPINSTIIAVALVPIGVAFGAPPAQTAWLISALYLATALGQPVVGRLIDLFGPRRLFLISTSLVGIAGIAGTLAPNLGCLIAARVLLGFGTCAGYPASMSLLRSEAERTGRDSPGGILTTLAVSSQTIAVIGPSLGGLLIDVGGWRATSALNIPLAAAALILGARRLPVQARPRRTGGRSIASELDLPGMALFAALLFSLLLFLMNLHADTWYLLAIAAAAAAAFAVRELRAPVPFIDLRVLAGNTPLLATYGRALVAYVVSYAFLYGFTQWAEEGRGLSPSQAGLVQLPIFLTGIAVSTLTGRHKSIRGKLLIGAVFQLAACTLLLRLGGTSPIWMLLAVALIFGVPQGLNSLALQNSVYYQADPARVGTSSGLLRTFIYLGSMVASAASATAFGQHADTGGMHHLAWFMLGAGALFLLLTVFDRGLRSVATPGSPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JUE6</accession>
    <name>A0A2M9JUE6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">TetR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_18725</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000005">
        <property type="protein sequence ID" value="PJN10511.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN10511">
        <property type="protein sequence ID" value="PJN10511"/>
        <property type="gene ID" value="CG723_18725"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004111">
        <property type="entry name" value="Repressor_TetR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02909">
        <property type="entry name" value="TetR_C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="19"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="42"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN10511.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="234" mass="25117" checksum="8D025516D8511D9A" modified="2018-04-25" version="1">MSPQPAAPRSRRERPAKPALTRDGIVAAAVMIMRDEGLKRVTMRRLAQELDTGPASLYVYVRNTAELHAAILDELLGEVDLSPATAAGDWQDRLVRILFSYTAVLFEHPSLARSALVAMPSGEHYLDLIEALLALLAEGGVPDAQAAWGVDALLQYATSTAAEQSTRDRDEDAQGDWDALTTALHDVSATSHPRLAALGDELLSGPGQARLGWGLRVLLNGMPHTPRPSSADTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JUN8</accession>
    <name>A0A2M9JUN8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ABC transporter substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_15090</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000004">
        <property type="protein sequence ID" value="PJN10548.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN10548">
        <property type="protein sequence ID" value="PJN10548"/>
        <property type="gene ID" value="CG723_15090"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006059">
        <property type="entry name" value="SBP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01547">
        <property type="entry name" value="SBP_bac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014708933" evidence="1">
        <location>
            <begin position="31"/>
            <end position="430"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN10548.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="430" mass="45033" checksum="E6DE71E5C7A1676A" modified="2018-04-25" version="1">MKLPVRMALPLAALALATACAPGTSDNGSAGDDKSGTLRVWLFQEVNNQPKRKVVDAAVAAFEKSHKGADVKVEYIPVETRAEKIKAAFNDPKSAPDVIEYGNTDTAGYVKDGGLADVTAEFGAWSEAKDTDPTAKESVTVDGKIYGAPYFVGVRALYYRTDVFKDLKLGVPTTQARLAATARKIHKAKPDLYGLAVGGAYTYGAMPFIWSQGGELAEKKGGSYESAIDSPAARKGIEAYTSLFGDDNCPAAKCAGMGGNDTVTAFASGKAGMAIGGDFSHQAMEDGKVKGKYAVVPLPGADKGGIAPAFAGGNNIGVLKSTSHRTLAVDLMKSLASKKTQGELFDAMGFLPTYTDVRESVAKKEPFVAPFIKTLGAGAKFVPASPAWGQIDASLVLPTMFQEIVSGRKDVATASRDAAKKMDTAFRTAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JV53</accession>
    <name>A0A2M9JV53_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_16415</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000004">
        <property type="protein sequence ID" value="PJN10766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN10766">
        <property type="protein sequence ID" value="PJN10766"/>
        <property type="gene ID" value="CG723_16415"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="334"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="375"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="407"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="455"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="484"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="539"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="829"/>
            <end position="854"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="887"/>
            <end position="908"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN10766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="924" mass="95729" checksum="3BD60EC226C92F45" modified="2018-04-25" version="1">MTPPTVAPWVRTRLRTAPGASWALALLVALTSFLAAVFPRAVEDYEDAGLRHAVSAEAPPRTVLTLTAEAGSEQESVARDEMMRSESMNTAYEDVLDSLRAPLAVDRAQSSYGLRTTTLLKAATDRWLPRPDGLPAEFTLSAQSGLARHSTVAAGRLPRAAGEVTWETTEVEGAVTAATAKALHIKPGSVIHVPAVMKGYVSVRITGVLKVRDPKASYWAAAPALAAPSLHQTQGRPPSDFWVGGLLLAPDAAPALLGTAGDPERFWQLAPDLGSLDARTMPALKSALAYTENGPGLLAVRVATGGDTEVATGLDEFITGYQELRSRIGPVVSVAAYGTGTVACIVLLMAGGLAAERRRAEFTVLRSRGGSVRGLAGRLLAETAVVAVPAGAAGLALALVAVRHGRWQPAVLAVAGAVLLTCLALPLRAAAAHRRVQVGGARDDLAHARPSRRRTVAELTLLVLAVASIVALRRRGTADGGDSLVALAPVLVGVVAAFVLVRVYPLPLRWLARPAGRLRGVVGYLSLARTGRATAGAGTAVLPLLALLTALTTAAFGGSVLSGIDHERDRAAVLATGADARVESGSALPTALTGQVRKIPGVRDVSPLTLRYDAEPKDGRRQVPLAAVDTASYARLAARTDLGAFPAGALTTNAARPGTAASPLPVLASPSMRDVFGTGPFSLLMDGEDIVLRVSAVRTTTPALSDDFLVVDRAALARRVGVDQKANQGIAPRYLPTSLLVTGDHIDGPALRKAAGSEVSVRLRATERARYVDSPLQTGAARVYSAAVVIGAGYAALTLLLALARAAPERTALLARLRTMGLTRRQARRLLILEALPQAVLAAAGGALTGWAAIRLLAPGLDLTGLALASAGGGGPVAQLRTDALSLLLPALCVVLLATAVAAGQAWWTGRRGFVRELRAGETS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JVF8</accession>
    <name>A0A2M9JVF8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_16905</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000004">
        <property type="protein sequence ID" value="PJN10849.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN10849">
        <property type="protein sequence ID" value="PJN10849"/>
        <property type="gene ID" value="CG723_16905"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="128"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="57"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="153"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="13"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="63"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN10849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="195" mass="20999" checksum="F2E48422D69F5EBE" modified="2018-04-25" version="1">MPEDVGGTPFPDGWEPDDDRDRGGADEEFASVVFDEDFVKAAEVHEPTAVERLLAAAQARAEAQEAEARRARTRGSAVDDDLYDDGYGPDPRGGYAHGPEVDDLYDPDVDEDGYPRPGAAKVRWRRPVAWLLALVMGIGMVALAFTAVYRGASSGGRQDRVPPPATTELEKGFPTAPSASAEYFQPPVPATPRTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JWX4</accession>
    <name>A0A2M9JWX4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Enoyl-CoA hydratase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_10700</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Lipid metabolism; fatty acid beta-oxidation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the enoyl-CoA hydratase/isomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN11384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN11384">
        <property type="protein sequence ID" value="PJN11384"/>
        <property type="gene ID" value="CG723_10700"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00659"/>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.12.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045002">
        <property type="entry name" value="Ech1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014748">
        <property type="entry name" value="Enoyl-CoA_hydra_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43149">
        <property type="entry name" value="PTHR43149"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN11384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="283" mass="30374" checksum="AB6FC71402BC1288" modified="2018-04-25" version="1">MIDTTSNELPDEGEGDGERRLRLRVEEGGIGVLTLCRPDKLNAWSWESSRQLGLLADRIRFDDTIRVVLLRAEGRAFCAGIDIRAPGGGITGRSGSERTRNYYEGIRWVHERFRAFAGLPQPVVAAVQGYCLGVGFELALMADVRIAADDAVFALPEAQLGVAVDAGGDLRIAREAGSGWAKFLALTGRRIDAATAHRLNLVQQVTGAAELEEAAHSVAAEIAANAPLAVQSVKRDIDAFADAGMGAALDRVAMSAALTLTSEDIREGYTAKAERREPRFDGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JX04</accession>
    <name>A0A2M9JX04_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CG723_10735</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CB01635</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN11389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN11389">
        <property type="protein sequence ID" value="PJN11389"/>
        <property type="gene ID" value="CG723_10735"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="21"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="83"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="120"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="144"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="194"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="254"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="81"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PJN11389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="288" mass="30864" checksum="61FD8F9BD631CE0F" modified="2018-04-25" version="1">MAELTWRTYGGARRSTRAWRVRTSAVLVAAVVLAVLVVPPLAHLDEQAVDLAAKLRPPSWAHPFGTDDVGRDLLLRCVYGLRVSLLVGVVAAVVATVIGTAVGALAGAVGGWTDRVVMRLVDVFSSVPHLLLGIFIVAMFRPGVWPVVVSVALTHWLSTARIVRAEVLSLRSRPYIDAAVSGGSSRWRIAVRHLLPGVLPQAALAAVLMVPHAIWHESALSFLGLGLPAHQASLGTLVQSARGSLLAGDWWPTLFPGLFIIVPTLAIAGLAGAWRERLNPRRRSELML</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JXI9</accession>
    <name>A0A2M9JXI9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Amidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_11215</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN11467.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN11467">
        <property type="protein sequence ID" value="PJN11467"/>
        <property type="gene ID" value="CG723_11215"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1300.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000120">
        <property type="entry name" value="Amidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020556">
        <property type="entry name" value="Amidase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023631">
        <property type="entry name" value="Amidase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036928">
        <property type="entry name" value="AS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11895">
        <property type="entry name" value="PTHR11895"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01425">
        <property type="entry name" value="Amidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75304">
        <property type="entry name" value="SSF75304"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00571">
        <property type="entry name" value="AMIDASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidase" evidence="2">
        <location>
            <begin position="29"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="147"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN11467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="479" mass="50077" checksum="C44BDD387B9E6885" modified="2018-04-25" version="1">MTHSPIDPFMPAVELAAAVRRKEVSPVEVADCFLERMDRLDPDLNAFCHRADDDVRKAASAAADAVARATSADDLPPFHGVPLPVKDLVDVAGWPTTYGSAGAGQAPAQASDPVVRRFADAGFVLLGKTTTSEFGSLPFTESTALGISRNPWDPDRTPGGSSSGAGAAVAAGMAPIAHAEDGGGSIRIPASCNGLVGLKPTRGLVTNAVVEVEGLGTSGVLTHSVADAAAALDVLACHDPAAWWSPPTPRTSFAAALRTDLPTGLRIGALTDSPIDGIRVHPACIAAVDRTLRTLESSGAHLVDTPLPLPPTDELVTAFTTLWNVGGAGIALAEPDQVEPHNRALRAAARAIDSWAYAEGVRKTQQLSRRIVEGFLAGFDLLVTPTMACLPPLVGAWRTGTDDDPLRALRNSYPMGVFTSVFNVTGQPAISLPIHHDEATGLPVGVQIVAAPWREDLLLQVSRTLELALPWATRRPPVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JXJ5</accession>
    <name>A0A2M9JXJ5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CG723_11980</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN11600.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN11600">
        <property type="protein sequence ID" value="PJN11600"/>
        <property type="gene ID" value="CG723_11980"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PJN11600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="187" mass="20898" checksum="62F48CEAA60E75C8" modified="2018-04-25" version="1">MAQVYLRRLSRWQAEQQRDSVADVYVSAYHGAAGAEYRDRQGFLTRFEKHGRRPDFDMVVADSGGLVGCVYGFRADRTGDWWAGFRGDLPTEFEELTASGRAFVLAELMVLPAHRRHGVATDLQVRLLTRHDTDLIVAAVDLPDPTGPEAPGSTLLRSWGWLHLGTSDPGGAPGARDRQLWVRRPLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JYW8</accession>
    <name>A0A2M9JYW8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Sugar ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CG723_14785</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CB01635</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN12060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN12060">
        <property type="protein sequence ID" value="PJN12060"/>
        <property type="gene ID" value="CG723_14785"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="75"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="107"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="146"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="187"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="218"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="245"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="75"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PJN12060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="281" mass="30682" checksum="A55859695DE1EBA9" modified="2018-04-25" version="1">MTAANSRTAKAPWVRPVAALVVTAAFFLPLYLVLTNVFKPGKDIAGHPASLPWPPTLDNLRAALDRPDRLFWNGLINSVTITLFSIVVLTVVSALLGHYLCRSRSRLARLTLLVLLAGLMIPPQVILVPVTEVLRLTGMMTTLQGIVAFNVGYYVPFGVFVFSGFIRTVPLELEESAQLDGAGRWRTFWQVVFPLLRPATASVLIFLGVWIWNDFLNPLIILGPAGGTTVTVGVYRAIGEHQADYGQVFGLMFLAALPVLIFYLALQRHFVKGLTGGAVKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JZ78</accession>
    <name>A0A2M9JZ78_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF305 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_12040</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN12171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN12171">
        <property type="protein sequence ID" value="PJN12171"/>
        <property type="gene ID" value="CG723_12040"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005183">
        <property type="entry name" value="DUF305"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012347">
        <property type="entry name" value="Ferritin-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03713">
        <property type="entry name" value="DUF305"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF305" evidence="1">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN12171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="54" mass="5804" checksum="1D51270B84D177CA" modified="2018-04-25" version="1">MTAHHMGGIDMASACAQQCEVPVERSLAQGMVDAQESEMKLMADLLRARGSSPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JZA2</accession>
    <name>A0A2M9JZA2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Gas vesicle protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_08410</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN12087.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN12087">
        <property type="protein sequence ID" value="PJN12087"/>
        <property type="gene ID" value="CG723_08410"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031411">
        <property type="term" value="C:gas vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005773">
        <property type="term" value="C:vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012506">
        <property type="term" value="C:vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000638">
        <property type="entry name" value="Gas-vesicle_GvpA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00741">
        <property type="entry name" value="Gas_vesicle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0304">Gas vesicle</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0926">Vacuole</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN12087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="75" mass="7891" checksum="4D4B155CE6AE35BB" modified="2018-04-25" version="1">MYDDVVPWDSPEPLNGPIGVPLVDLLDRLLATGVVISGDLVIAIADVPLVRLSLHALLSSVNERVPAPWADGGPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JZA5</accession>
    <name>A0A2M9JZA5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">AsnC family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CG723_13320</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN12204.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN12204">
        <property type="protein sequence ID" value="PJN12204"/>
        <property type="gene ID" value="CG723_13320"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000485">
        <property type="entry name" value="AsnC-type_HTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019888">
        <property type="entry name" value="Tscrpt_reg_AsnC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019887">
        <property type="entry name" value="Tscrpt_reg_AsnC/Lrp_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01037">
        <property type="entry name" value="AsnC_trans_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13404">
        <property type="entry name" value="HTH_AsnC-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00033">
        <property type="entry name" value="HTHASNC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00344">
        <property type="entry name" value="HTH_ASNC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH asnC-type" evidence="6">
        <location>
            <begin position="23"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="domain" description="AsnC_trans_reg" evidence="5">
        <location>
            <begin position="82"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="domain" description="HTH asnC-type" evidence="6">
        <location>
            <begin position="190"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PJN12204.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="349" mass="38162" checksum="A0B9E22ED6698850" modified="2018-04-25" version="1">MPDASTEVPEERRDAAAGSLQESDLALIEALQRSPRAPWSQIGPALGVDATSAARRWHRLVAQGLAWLTAYPSASTTSFAYVDVRCRPNTVDDVTRHLCALPQVLSVEEVTGDFDLFMTVAAPTPAALAALVRRDLPTAPGVEATAVHLGLRLYQEGSGWRMRALDRQQRSLLAPRQQPPRRSPKAATADAALIAALGRDGRRSHQELARDLGVSEATVRRRVQRLMETRSVHFRCDFAQSAAGWPLAATYRIDLPAHQLTAAARTLGLMPEVRLCSAVSGTANFLVIAWLRTTEDVTGFEAHMCEQLPDLRVRDRTVTLVTAKRMGRLLDPHGRAVGHVPWDDPSTTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-05-25" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JZF2</accession>
    <name>A0A2M9JZF2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Aldo/keto reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_04045</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000002">
        <property type="protein sequence ID" value="PJN12244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN12244">
        <property type="protein sequence ID" value="PJN12244"/>
        <property type="gene ID" value="CG723_04045"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NADP_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="SSF51430"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldo_ket_red" evidence="1">
        <location>
            <begin position="26"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN12244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="344" mass="36427" checksum="4118292A329BA059" modified="2018-04-25" version="1">MSPTTPTSPTLHLRSLGSTGPQVSAIGLGCMGMSALYGEADRGESIATVHAALDAGITLLDTGDFYAMGHNEMLIGEALRTAPAAHREKALTSVKFGALRDPDGGWSGYDGRPAAVKNFAAYSLQRLGVDHIDVYRIARVDPDVPIEETVGAIAELVEKGHVRHIGLSEVGADTIRRAAATAPISDLQIEYSLISRGIEEAILPVARELGIGVTAYGVLSRGLISGHFGRDRKLAANDFRGMSPRFQGENLQHNLDLVESLRKIAEQKGASVAQVAIAWVLSRGDDIVPLVGARRRDRLTEALGALDVTLDSADLAAIEKAVPAGAAAGDRYPEAQMAHLDSER</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JZM1</accession>
    <name>A0A2M9JZM1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_04465</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000002">
        <property type="protein sequence ID" value="PJN12314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN12314">
        <property type="protein sequence ID" value="PJN12314"/>
        <property type="gene ID" value="CG723_04465"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="25"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="70"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="140"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="167"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="206"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="245"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="249"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN12314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="265" mass="28570" checksum="398F7184A01FB0CE" modified="2018-04-25" version="1">MRDLGAGFGYLMKGQRWVSQHGKQFGMGLLPGLITLVLYAAALVCLALWGDDFVTWATPFADDWTSPWAGLFRGFLTAVLFALVLLLAVLAFTAVTLLIGQPFYESLSEKVDLAEGGHAPESGLPLWRELWISARDSLRVLVRAALWGVLLFALGFVPFVGQTVVPVLGFFVTGFFLTEELAAVALQRRSVELRERLALLRSRKGLAWGFGTPLAVAFLVPVVAVFLMPGAVAGATLMARDLLGETTPEPAPEPAPHPTGDPATH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JZM8</accession>
    <name>A0A2M9JZM8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_04625</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000002">
        <property type="protein sequence ID" value="PJN12343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN12343">
        <property type="protein sequence ID" value="PJN12343"/>
        <property type="gene ID" value="CG723_04625"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007427">
        <property type="entry name" value="DUF475"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04332">
        <property type="entry name" value="DUF475"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="30"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="65"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="115"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="157"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="193"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="236"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="269"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="315"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="339"/>
            <end position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN12343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="382" mass="41429" checksum="9F43E0E8F9287996" modified="2018-04-25" version="1">MVLKTFGWSFAITALGLVAAVFYDGWTAFGVVAILAVLEISLSFDNAVINAGILKKMNAFWQKIFLTVGVLIAVFGMRLVFPVVIVAVSAKLGPIEAVKLALNDKDKYQQLVTDAHPSIAAFGGMFLLMIFLDFIFEERDVQWLRWIERPLAKLGKVDMLSVCIAMIVLLISSFTVATHAHQHGGAHVDKAETVLIAGVAGLITYLIVGGLSGYFENRLEEEEEREHEVEEEARKSGKAAPAIAMAGKAAFFMFLYLEVLDASFSFDGVIGAFAITNDIVLMALGLGIGAMYVRSLTVYLVRQGTLDDYVYLEHGAHYAIGALAVILLVTIQYEINEVITGLIGVVLIAWSFWSSVRRNSRIAAAEGKAAASGEKAEVSSGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JZR8</accession>
    <name>A0A2M9JZR8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_04855</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000002">
        <property type="protein sequence ID" value="PJN12383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN12383">
        <property type="protein sequence ID" value="PJN12383"/>
        <property type="gene ID" value="CG723_04855"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030802">
        <property type="entry name" value="Permease_MalE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30188">
        <property type="entry name" value="PTHR30188"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02405">
        <property type="entry name" value="MlaE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="39"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="100"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="145"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="199"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="242"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN12383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="268" mass="28484" checksum="4BFE5AF31C496D38" modified="2018-04-25" version="1">MASPLVWLDRSGDQLIFYVRALVWIPRTLRRYLKEVQRLLAEVAFGSGGLGVIGGTIGVMFAMTVFTGTVVGLQGYAALDQIGTAAFTGFVSAYFNTREIAPLVAGLALSATVGAGFTAQLGAMRINEEVDALEGMGIRSMPYLVTTRIIAGVVAIVPLYAIGLLSSYLASRYVTVWFNGQSQGTYDHYFNLFLSPADVLLSVLKVLIFSVMVIVAHCYYGFRASGGPAGVGVAVGRSVRNAIVLISVTDFFLSLALWGATTTVKVAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JZV1</accession>
    <name>A0A2M9JZV1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Cobalt ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CG723_04935</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000002">
        <property type="protein sequence ID" value="PJN12394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN12394">
        <property type="protein sequence ID" value="PJN12394"/>
        <property type="gene ID" value="CG723_04935"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03225">
        <property type="entry name" value="ABC_cobalt_CbiO_domain1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015856">
        <property type="entry name" value="ABC_transpr_CbiO/EcfA_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="2"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="308"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="268"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="36"/>
            <end position="43"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="340"/>
            <end position="347"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PJN12394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="563" mass="59343" checksum="C1EF99F4DD7CC168" modified="2018-04-25" version="1">MIRFEDVSVTYDGAATPTVRDIRLDVPEGELVLLVGPSGVGKSTLLGAVSGLVPHFTGGTLSGRVTVAGRDTRTHKPRELADVVGTVGQDPLSHFVTDTVEDELAYGMESLGLAPDVMRRRVEETLDLLGLADLRDRPIATLSGGQQQRVAIGSVLTPHPRVLVLDEPTSALDPAAAEEVLAVVQRLVHDLGTTVLMAEHRLERVVQYADQVALLPGPGEPLLLGAPAEIMAVSPVFPPVVDLGRLAGWSPLPLTVRDARRRSGELRERLAGHEPREPHEQPQATASPDSRRSPLRRTRKQPEVAAVAEVAGLAVRRGRVEALRHVDLTVGPGEIVALMGRNGAGKSTLLSTLVGLVRPSSGTALVGGAVPHRTGPRELIRRVGLVPQEPRDLLYADTVAAECAAADHDAGAGPGTCRALVSRLLPGIADDTHPRDLSEGQRLTLALAIALTARPPLLLLDEPTRGLDYAAKARLITVLRGLAAEGHAVVLATHDVELAAELSHRVAVLADGEIVANGPTPEVVVASPAFSPQVAKVLAPGEWLTVAQVREALESAGGPEERV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K059</accession>
    <name>A0A2M9K059_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Lipoyl synthase</fullName>
            <ecNumber evidence="6">2.8.1.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Lip-syn</fullName>
            <shortName evidence="6">LS</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Lipoate synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Lipoic acid synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Sulfur insertion protein LipA</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">lipA</name>
        <name evidence="8" type="ORF">CG723_05670</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CB01635</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>[[Fe-S] cluster scaffold protein carrying a second [4Fe-4S](2+) cluster] + 4 H(+) + N(6)-octanoyl-L-lysyl-[protein] + 2 oxidized [2Fe-2S]-[ferredoxin] + 2 S-adenosyl-L-methionine = (R)-N(6)-dihydrolipoyl-L-lysyl-[protein] + 2 5'-deoxyadenosine + [[Fe-S] cluster scaffold protein] + 4 Fe(3+) + 2 hydrogen sulfide + 2 L-methionine + 2 reduced [2Fe-2S]-[ferredoxin]</text>
            <dbReference type="Rhea" id="RHEA:16585"/>
            <dbReference type="Rhea" id="RHEA-COMP:9928"/>
            <dbReference type="Rhea" id="RHEA-COMP:10000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10001"/>
            <dbReference type="Rhea" id="RHEA-COMP:10475"/>
            <dbReference type="Rhea" id="RHEA-COMP:14568"/>
            <dbReference type="Rhea" id="RHEA-COMP:14569"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17319"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="ChEBI" id="CHEBI:29919"/>
            <dbReference type="ChEBI" id="CHEBI:33722"/>
            <dbReference type="ChEBI" id="CHEBI:33737"/>
            <dbReference type="ChEBI" id="CHEBI:33738"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:78809"/>
            <dbReference type="ChEBI" id="CHEBI:83100"/>
            <dbReference type="EC" id="2.8.1.8"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="6">Binds 2 [4Fe-4S] clusters per subunit. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.</text>
    </comment>
    <comment type="pathway">
        <text evidence="6">Protein modification; protein lipoylation via endogenous pathway; protein N(6)-(lipoyl)lysine from octanoyl-[acyl-carrier-protein]: step 2/2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the radical SAM superfamily. Lipoyl synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.8.1.8" evidence="6"/>
    <dbReference type="EMBL" id="NNBL01000002">
        <property type="protein sequence ID" value="PJN12521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN12521">
        <property type="protein sequence ID" value="PJN12521"/>
        <property type="gene ID" value="CG723_05670"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00538">
        <property type="reaction ID" value="UER00593"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016992">
        <property type="term" value="F:lipoate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102552">
        <property type="term" value="F:lipoyl synthase activity (acting on glycine-cleavage complex H protein"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102553">
        <property type="term" value="F:lipoyl synthase activity (acting on pyruvate dehydrogenase E2 protein)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009249">
        <property type="term" value="P:protein lipoylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00206">
        <property type="entry name" value="Lipoyl_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaB/NifB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031691">
        <property type="entry name" value="LIAS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003698">
        <property type="entry name" value="Lipoyl_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10949">
        <property type="entry name" value="PTHR10949"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16881">
        <property type="entry name" value="LIAS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005963">
        <property type="entry name" value="Lipoyl_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00271">
        <property type="entry name" value="lipoyl_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 6" id="KW-0408">Iron</keyword>
    <keyword evidence="5 6" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="3 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Radical SAM core" evidence="7">
        <location>
            <begin position="68"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="56"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="61"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="67"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="82"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="86"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="89"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="298"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PJN12521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="321" mass="36228" checksum="926677B6A515238B" modified="2018-04-25" version="1">MSAVAPDGRKMLRLEVRNSQTPIERKPEWIKTRAKMGPEYTKMQGLVKSEGLHTVCQEAGCPNIYECWEDREATFLIGGDQCTRRCDFCQIDTGKPEALDRDEPRRVGESVVTMDLNYATITGVARDDLEDGGAWLYAETVRQIHAMTAERAEGYTKVELLIPDFNADPDQLAEVFSSRPEVLGHNVETVPRIFKRIRPGFRYERSLEVITKAREAGLVTKSNLILGMGEERAEVSEALRQLHEAGTELITITQYLRPTPRHHPVERWVKPAEFVELKEEAEQIGFSGVMSGPLVRSSYRAGRLYQMAVEKRGAYVASQAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-05-25" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K0F0</accession>
    <name>A0A2M9K0F0_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Glucokinase</fullName>
            <ecNumber evidence="2">2.7.1.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Glucose kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CG723_06005</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CB01635</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ROK (NagC/XylR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.2" evidence="2"/>
    <dbReference type="EMBL" id="NNBL01000002">
        <property type="protein sequence ID" value="PJN12584.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN12584">
        <property type="protein sequence ID" value="PJN12584"/>
        <property type="gene ID" value="CG723_06005"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004340">
        <property type="term" value="F:glucokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000600">
        <property type="entry name" value="ROK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004654">
        <property type="entry name" value="ROK_glcA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18964">
        <property type="entry name" value="PTHR18964"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00480">
        <property type="entry name" value="ROK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00744">
        <property type="entry name" value="ROK_glcA_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01125">
        <property type="entry name" value="ROK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00014701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00032386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PJN12584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="317" mass="33150" checksum="0D76A4BED067052F" modified="2018-04-25" version="1">MGLTIGVDIGGTKIAAGVVDEEGNILSTFKVPTPSTSEAIVDAIASAVEGARAGHEIVGVGIGAAGYVNRQRSTVYFAPNIDWRQEPLKEEVEKRVGLPVVVENDANAAAWGEYKFGAGKGHRNVICITLGTGLGGGIIIGNKLRRGHFGVAAEFGHIRMVPDGLLCGCGSQGCWEQYASGRALVRYAKQRANATPENAEFLLSLGDGTPDGIEGKHISMAARQGDAVAVDSYRELARWAGAGLADLASLFDPSAFIVGGGLSDEGELVLDPIRKSYKRWLVGGNWRPVADVIAAQLGNKAGMVGAADLAREPDPIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-05-25" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K0L8</accession>
    <name>A0A2M9K0L8_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Tryptophan synthase alpha chain</fullName>
            <ecNumber evidence="7">4.2.1.20</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">trpA</name>
        <name evidence="9" type="ORF">CG723_06485</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CB01635</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>(1S,2R)-1-C-(indol-3-yl)glycerol 3-phosphate + L-serine = D-glyceraldehyde 3-phosphate + H2O + L-tryptophan</text>
            <dbReference type="Rhea" id="RHEA:10532"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:57912"/>
            <dbReference type="ChEBI" id="CHEBI:58866"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="4.2.1.20"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 7">Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 5/5.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Tetramer of two alpha and two beta chains.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7 8">Belongs to the TrpA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.20" evidence="7"/>
    <dbReference type="EMBL" id="NNBL01000002">
        <property type="protein sequence ID" value="PJN12668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN12668">
        <property type="protein sequence ID" value="PJN12668"/>
        <property type="gene ID" value="CG723_06485"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00035">
        <property type="reaction ID" value="UER00044"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004834">
        <property type="term" value="F:tryptophan synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04724">
        <property type="entry name" value="Tryptophan_synthase_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00131">
        <property type="entry name" value="Trp_synth_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011060">
        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018204">
        <property type="entry name" value="Trp_synthase_alpha_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002028">
        <property type="entry name" value="Trp_synthase_suA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43406">
        <property type="entry name" value="PTHR43406"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00290">
        <property type="entry name" value="Trp_syntA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51366">
        <property type="entry name" value="SSF51366"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00262">
        <property type="entry name" value="trpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00167">
        <property type="entry name" value="TRP_SYNTHASE_ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="5 7" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="6 7" id="KW-0456">Lyase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0822">Tryptophan biosynthesis</keyword>
    <feature type="active site" description="Proton acceptor" evidence="7">
        <location>
            <position position="53"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="7">
        <location>
            <position position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00131"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PJN12668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="271" mass="27805" checksum="A3E4A0291A1EDAF3" modified="2018-04-25" version="1">MSGNIQLLNDTLAAARAEGRSALIAYLPAGFPTVDGGIEAIKAVFDGGADVVEVGLPHSDPVLDGPVIQTADDIALRGGVRIADVMRTVREAHAATGKPVLVMTYWNPIDRYGIERFTAELAEAGGAGCILPDLPVQESGTWREHADKHGLGTVFVVAPSSKDERLATITAAGSGFVYAASLMGVTGTRESVGNQAQDLVRRTKATTDLPVCVGLGVSNAKQAAEVAGFADGVIVGSAFVKLMLDADDEAAGLAAVRALAADLADGVRAKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K0Z2</accession>
    <name>A0A2M9K0Z2_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">YceI domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_07170</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000002">
        <property type="protein sequence ID" value="PJN12784.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN12784">
        <property type="protein sequence ID" value="PJN12784"/>
        <property type="gene ID" value="CG723_07170"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.128.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007372">
        <property type="entry name" value="Lipid/polyisoprenoid-bd_YceI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036761">
        <property type="entry name" value="TTHA0802/YceI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04264">
        <property type="entry name" value="YceI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00867">
        <property type="entry name" value="YceI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101874">
        <property type="entry name" value="SSF101874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YceI" evidence="1">
        <location>
            <begin position="24"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN12784.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="193" mass="20487" checksum="D3DC709AC24732C4" modified="2018-04-25" version="1">MTYDDNSGATATTSATALPLAAGDWTLDPLHSAVNFTIRHLGIAKVRGRFAQVEAALHIGERVDDIRVSATIALASIDTGNADRDAHVRQADLLDVERRPTMTYVSHGVSGKDDDWSLEGELTVGDVTRPVALAVEFGGVVDVPMDGSRHAGFEATGEIRRSDFGLDFGAGLLGDVVKIQLDMQFVEPQGQGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K104</accession>
    <name>A0A2M9K104_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DNA polymerase subunit beta</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_06985</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000002">
        <property type="protein sequence ID" value="PJN12750.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN12750">
        <property type="protein sequence ID" value="PJN12750"/>
        <property type="gene ID" value="CG723_06985"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041633">
        <property type="entry name" value="Polbeta"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18765">
        <property type="entry name" value="Polbeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="SSF81301"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Polbeta" evidence="2">
        <location>
            <begin position="15"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF18765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN12750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="253" mass="27326" checksum="9594B1A4B17B6BC6" modified="2018-04-25" version="1">MTDDVFPDHVAERLAALPGVRAVALGGSRAQGTQRPDSDWDFAIYYRGDFQPDDLRGVGWEGEVSEIGGWGGGVFNGGAWLTVDGRRADVHYRDLDVVERELAEAGRGRVRWEPLMFHLAGIPTYLVVAELAVNQVLRGTAPRPDRYPEALRKAAPEMWWSRASGTLHYARANNAPTGGRAEVHGAVAVAAMSAAHAVLAARGEWVTNEKRLLERAGLLGVHSLLAGASGDLTDVVDRTQVLLESAVDAARRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-05-25" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K134</accession>
    <name>A0A2M9K134_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Alcohol dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CG723_07485</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CB01635</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000002">
        <property type="protein sequence ID" value="PJN12845.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN12845">
        <property type="protein sequence ID" value="PJN12845"/>
        <property type="gene ID" value="CG723_07485"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="PKS_ER"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="PKS_ER" evidence="3">
        <location>
            <begin position="4"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PJN12845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="329" mass="34666" checksum="8CA7492302B283AA" modified="2018-04-25" version="1">MKAAVIESVGKAVVTEVPDPTPGPRDVVVEVAACGLCGTDLHILQGEFAPTLPVVPGHEFAGVVVGLGRDVREVSVGDRVAVDPSLYCYECRYCRSGHNNLCERWAAIGVTTAGGAAQYAVAPVANCVRLPDHVRTEDAALIEPLSCAVRGYDVLNSRLGSHVLIYGSGTMGLMMLELAKRTGAASVDVVDLNADRLATARKLGVSGSGADADELDRPQGWDVVIDATGNAGAIQDGLERVAKAGTFLQFGVADYATRVSIDPYRIYNQEITITGSMAVLHSYERAAELFAGGVLDPDVFISDRLPLEAYPQALDQFASGVGRKIVVVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K1A6</accession>
    <name>A0A2M9K1A6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CG723_07925</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000002">
        <property type="protein sequence ID" value="PJN12923.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN12923">
        <property type="protein sequence ID" value="PJN12923"/>
        <property type="gene ID" value="CG723_07925"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PJN12923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="73" mass="8406" checksum="55DAE08109A00E18" modified="2018-04-25" version="1">MSDENPICSAKGCRVDAVWVLAWNNPKLHTPERRKTWLACDEHREHLSQFLGVRGFLKDVVALKDWESGDREG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K1N0</accession>
    <name>A0A2M9K1N0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="13">ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CG723_08005</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">CB01635</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000002">
        <property type="protein sequence ID" value="PJN12937.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN12937">
        <property type="protein sequence ID" value="PJN12937"/>
        <property type="gene ID" value="CG723_08005"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00060">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC_2_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000253">
        <property type="entry name" value="FHA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01061">
        <property type="entry name" value="ABC2_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00498">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00240">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SSF49879"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50006">
        <property type="entry name" value="FHA_DOMAIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 8 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="596"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="635"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="675"/>
            <end position="701"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="721"/>
            <end position="741"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="748"/>
            <end position="769"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="822"/>
            <end position="844"/>
        </location>
    </feature>
    <feature type="domain" description="FHA" evidence="11">
        <location>
            <begin position="34"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="domain" description="FHA" evidence="11">
        <location>
            <begin position="201"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="12">
        <location>
            <begin position="283"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="89"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="103"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="149"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="323"/>
            <end position="330"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PJN12937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="854" mass="92558" checksum="DB773E3F092B1BF5" modified="2018-04-25" version="1">MGASSGDNSVGHGVPELVLELNGRTWTLDPSRPYTLGRDPQGDVAIDDARVSWRHATISWGGRSWVIEDHGSTNGTFVQGQRIHQMEIGPGSTLHLGNATDGPRVNLSGSASGAAVPAAQQAQQQAHPQQAPVQKPQGGDPGWAHNAPPQQQVPAQQSWQQPQQAQNIPPQQGPGGVAGAPPVYGDRSPTTFHQLALGRVMRIGRALENELVVSDLQVSRLHAEFHATPDGRYEIRDLGSHNGTYVNGMPIAKGGSALLGPNDIVGVGHSTFRLVGDRLEEFVDTGEVSFSARHLTVTVDGGKDILKDVSFGVPEKSLIAVIGPSGSGKSTLLKALTGYRPANKGDVLYDNRNLYKQFAELRQRIGLVPQDDILHKELTVKKALKYAAKLRFPSDTSVQEREQRIDEVLRELKLDIHKEKKVTSLSGGQRKRVSVALELLTKPSLIFLDEPTSGLDPGMDRDVMQLLRGLADDGRTVLVVTHSVAELAICDKLLVMAPGGSVAYFGPPEEALNFFGYSTWADVFSAFENYRDYDWAGRWKGSQHYQMYAADIDAVAAQSVHMPPPQAMKPPKPQGWGSQLWTLIRRYTSVIASDKGFLGLMVILPAVLGVVSTVIPADFGLAPPKPPSRFNGDAGTIMLILAVGMCFSGAANSVRELIKERVIYERERATGLSRSAYLMSKVIVLGVVTAIQGVIICAIGFFPRDLPAEGLMMPPAVELCIVIIALGFTSMMFGLVISSLVKTAEKTMPLLVMFAIVQVVFTGILFQVYGSPGLEQFAWLMPSRWAIAGAGSTLDLAHLMPPWDQAHPNDLDPLWEHSVSQWGINLAILIALGVICGFAVARLLRRHEPEVMRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K1T1</accession>
    <name>A0A2M9K1T1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Iron transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CG723_00280</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CB01635</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the IucA/IucC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000001">
        <property type="protein sequence ID" value="PJN13079.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN13079">
        <property type="protein sequence ID" value="PJN13079"/>
        <property type="gene ID" value="CG723_00280"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016881">
        <property type="term" value="F:acid-amino acid ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019290">
        <property type="term" value="P:siderophore biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007310">
        <property type="entry name" value="Aerobactin_biosyn_IucA/IucC_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022770">
        <property type="entry name" value="FhuF_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037455">
        <property type="entry name" value="LucA/IucC-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34384">
        <property type="entry name" value="PTHR34384"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06276">
        <property type="entry name" value="FhuF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04183">
        <property type="entry name" value="IucA_IucC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="IucA_IucC" evidence="3">
        <location>
            <begin position="289"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="domain" description="FhuF" evidence="4">
        <location>
            <begin position="560"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="143"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="17"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="233"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF06276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PJN13079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="740" mass="79544" checksum="9D10C4A1A93D19D7" modified="2018-04-25" version="1">MNATPAPDDRHRPQASGACDTQPQLAPECGTTVPRQKDGSQEAEHLHGSTADLLEHPDPGTAAQAAAVENLLRCWVRENDLAEPPHGTLRIPLPASGTALLIPVHHWSVTGWHRFGMPHLQDGPLDAPRVDAVTVAALLSREASGPGSAPAVRGGVPARDAGGSGADVAARVGVVPGPAHTPDTTSGTHAGPEPVNGPAPTASSPTPSVPARTQAVPEAVAAASASMAPHPETQSPHPEPSRPTTPHHSHPTPSGDGADLVGRVADSVRRTADFIAHRRSNPRDTTDLFLAAEQSLLLGHPLHPTPKSREGLSEAESRLYSPELQGSFPVHWMAVNRSVLAMDSAWTQRGRPLPADQLALQLAGTELPLPDGHAALPLHPWQVRELKHRPQAAALLDAGLLRDLGPHGAPWYPTSSVRTLYQPDASAMLKLSLGLRITNSRRENLRKELHRGVEVHRLLRTGLFEQWQAAHPGFDIVRDPAWLAVNGPDGEPVPGLDVMIRNNPFAPGDDAACIAGFVSPRPPALAHGQRDRQLMRSRLAETITRLAGRTGRPRGAVAAEWFLRYLEHVVRPVLWLDSTAGVALEAHQQNTLLLLDPEGWPVGGRYRDNQGYYFRESRRAELDGRLPGIGSHSDTFVSDDVTDERFAYYLGINNIFGLIGAFGSQQLADERLLLAAFRGFLSDVASGPDKLRTPLPRYLLDSPALRCKANLLTRLHGLDELVGPVDTQSVYVTIANPLHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K1U2</accession>
    <name>A0A2M9K1U2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Histidine phosphatase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CG723_00330</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000001">
        <property type="protein sequence ID" value="PJN13088.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN13088">
        <property type="protein sequence ID" value="PJN13088"/>
        <property type="gene ID" value="CG723_00330"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07067">
        <property type="entry name" value="HP_PGM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001345">
        <property type="entry name" value="PG/BPGM_mutase_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00300">
        <property type="entry name" value="His_Phos_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00855">
        <property type="entry name" value="PGAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="SSF53254"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00175">
        <property type="entry name" value="PG_MUTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PJN13088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="219" mass="25902" checksum="BE74B1F8F27B4189" modified="2018-04-25" version="1">MARPRRIVLVRHGESEGNADDTVYEREPDHALALTETGHRQADETGKYLRELFGREQVSVYVSPYRRTHQTFRAFRLDPELVRVREEPRLREQDWGNWQDRDDVRLQKAYRDAYGHFFYRFAQGESGADVYDRVGAFLESLYRSFEAHDHPSNVLLVTHGLTMRLFCMRWFHWTVADFECLSNPRNGETRALVLGKDGKYTLDRPFERWRDPEPYGVTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K239</accession>
    <name>A0A2M9K239_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Polynucleotide kinase-phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CG723_00960</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000001">
        <property type="protein sequence ID" value="PJN13194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN13194">
        <property type="protein sequence ID" value="PJN13194"/>
        <property type="gene ID" value="CG723_00960"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07423">
        <property type="entry name" value="MPP_Prp_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP_ApaH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041780">
        <property type="entry name" value="MPP_PrpE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024028">
        <property type="entry name" value="PNKP_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032390">
        <property type="entry name" value="PNKP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032380">
        <property type="entry name" value="PNKP_ligase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16536">
        <property type="entry name" value="PNKP-ligase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16542">
        <property type="entry name" value="PNKP_ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="SSF56300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04075">
        <property type="entry name" value="bacter_Pnkp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Metallophos" evidence="1">
        <location>
            <begin position="191"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="domain" description="PNKP_ligase" evidence="3">
        <location>
            <begin position="465"/>
            <end position="794"/>
        </location>
    </feature>
    <feature type="domain" description="PNKP-ligase_C" evidence="2">
        <location>
            <begin position="799"/>
            <end position="857"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF16536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF16542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PJN13194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="857" mass="94191" checksum="EF0D3F5AF76C8060" modified="2018-04-25" version="1">MTTTPGSHARTLPVTDLSLVVLIGASGSGKSTFARRHFKPTEIISSDFCRGLVADDENDQSASRDAFDVLHYIAGKRLAAGRLTVVDATNVQQESRKQLVDLARQYDVLPIAIVLDIPEEVCAARNAERADRAGMHRRVISRHTRELRRSLRHLEREGFRKVHILRGVEEADSAEVVREKRYNDLTHLTGPFDIIGDIHGCAFELEMLLTRLGYADGVHPEGRTAVFVGDLVDRGPDSPGVLRRVMSMVKSGHALCVPGNHENKFGRYLKGRKVQHTHGLAETVEQFAGESEEFTQEVAEFVDGLVSHYVLDGGKLVVCHAGLPEKYHGRTSGRVRSHALYGDTTGETDEFGLPVRYPWAEDYRGSAAVVYGHTPVPQATWLNNTICLDTGAVFGGKLTALRWPERELVDVPAQKVWYEPSRPLRTEAPGGQDGRPLDLADVHGRRAVETRHAGRVAVREENAAAALEVMSRFAVDPRLVPYLPPTMAPTATSREEARGGAADEHFLEHPAEAFAQYAADGVGRVVCEEKHMGSRAVALVCRDAEVARERFGVPEGPTGALYTRTGRSFFADEQVTEEILGRVRAAVTDAGLWDELDTDWLLLDTELMPWSLKASGLLRSQYAAVGAASGAVFPGAIAGLEAAAARGVDVGELLGRQRERAEDAAAFTDAYRRYCWTTDGLDGVRLAPFQILAVQGRSLAALPHDEQLALIDRMVEHDGSGLLQTTRRLFVDTGDEASVSAGVDWWLEMTGRGGEGMVVKPVEALTRDGKGRLVQPGIKCRGREYLRIIYGPEYTRPDHLERLRGRFLGHKRSLAVREYALGLEALDRLADGEPLWRVHEAVFAVLALESEPVDPRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K2D5</accession>
    <name>A0A2M9K2D5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GNAT family N-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_01470</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000001">
        <property type="protein sequence ID" value="PJN13281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN13281">
        <property type="protein sequence ID" value="PJN13281"/>
        <property type="gene ID" value="CG723_01470"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="186"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN13281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="316" mass="35382" checksum="890F61FBF03E8BF9" modified="2018-04-25" version="1">MTAAPHGSPHPAHDDTRPVVRALTEEDVPLFRTFDDPGLVGRVITGVGYRTVTEGGDYRPEWTWVALREGRVVARAAWWGGKDDTEPVNLNWFDVLEDDIEAGAELLRQAPFDVEYELILPAGWREDPRTRAAAEARMEAVTRAGKKLLVERLRYRWTPENGLPERPGRLEFRAEPDDEVILDVLRRVHSATLDAHARRAIEESGLDTAAQEELDFFHWCPSPREWWQLAYTPQGELAGLHIPAHNPGGPCIGFIGVVPEQRGHGYAYDLLVESTHFLVEQGAEFIAGATDDGNFPMAANFAKAGYPVTEKRINFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K2F9</accession>
    <name>A0A2M9K2F9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">2-dehydropantoate 2-reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CG723_01625</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CB01635</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ketopantoate reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000001">
        <property type="protein sequence ID" value="PJN13305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN13305">
        <property type="protein sequence ID" value="PJN13305"/>
        <property type="gene ID" value="CG723_01625"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013752">
        <property type="entry name" value="KPA_reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013332">
        <property type="entry name" value="KPR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02558">
        <property type="entry name" value="ApbA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08546">
        <property type="entry name" value="ApbA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="SSF48179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ApbA" evidence="3">
        <location>
            <begin position="4"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="domain" description="ApbA_C" evidence="4">
        <location>
            <begin position="187"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="245"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02558"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PJN13305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="335" mass="35113" checksum="616F12AF8C897C41" modified="2018-04-25" version="1">MRYLIIGAGAVGGAIGGRLAQAGHDVVLVARGKQYEALRDHGLRLVTPDGPHIHRLPVVAGPGALGELSPDDVLVLAVKTQDSVAALEAWAGRPVAGGGTAAERLALVCAQNGVESERLALRLFRRVYGMCVWLPATFVEPGVVSAAGTPLTGILHIGRYPEGTDETAQRISADLEKSFFEAPVVPDVMRWKYAKLLGNLANAIEAVSGVITSEAGLALHGRARAEGEAVLAAAGIAFASKEEEKESRGDKIRFEPFDGSERSGGSSWQSLSRGTGTIESDYLNGEMGLLGRLHGVPTPVNDALQSVADRFAREGRPAGSMQITELISKAAAAPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K2K0</accession>
    <name>A0A2M9K2K0_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">SSD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CG723_01600</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CB01635</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000001">
        <property type="protein sequence ID" value="PJN13300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN13300">
        <property type="protein sequence ID" value="PJN13300"/>
        <property type="gene ID" value="CG723_01600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004869">
        <property type="entry name" value="MMPL_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000731">
        <property type="entry name" value="SSD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03176">
        <property type="entry name" value="MMPL"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50156">
        <property type="entry name" value="SSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="24"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="199"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="247"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="292"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="319"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="381"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="542"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="575"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="613"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="655"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="691"/>
            <end position="714"/>
        </location>
    </feature>
    <feature type="domain" description="SSD" evidence="7">
        <location>
            <begin position="212"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PJN13300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="751" mass="78953" checksum="7F9663AADCB6E8CD" modified="2018-04-25" version="1">MGNRDTRVRGLAARAGGWSVRHRWAAVGIWVLFVVLAMGIGTAAGRVDVSDSDQLQGETTQAARIIDDAGIEEPAGETVLVQGRDGKVRATDADFRRAVDEVVKAVQGTGAATNVKSPYDPGAKTISKDGRSALVQFDMRGDPGTASDRVEPVLKAVEKVQRTHGSLRIEEIGGASMGKTFEDAFGNDFQRAEYSAVPVALGILLIAFGALVAALLPVALAVTAIMATMGLMGIVSHLQPMSDTANSVMLLVGLAVGVDYCLFYLRREREERMKGHDPQTALRVAAATSGRAIIVSGVTVCVAMAGMLFTGLAEFQAMGLASLMVVAVAMVGSVTVLPALLSLLGERVEKGRLPFLNRGRRRNGNGAPEGSRFWQAVLRVVLARPAVSVVVAIGALLAVTAPALGMKTQNLTLDQEFGDSLPIVATYDRLNDAFPGGSEPAEVVVKAADINAPEVRSAIAGFREAAVSSGASRGPVDLTVHGRENVAFISVPLVGGSDQDRAEKSLALIRDQVRPDTLGKVDGVEAPVTGQVAGSKDFNDQIVGSVVPVFAFVVVFAFLLMLLSFRSLTVAITSIALNLLSVGAAYGILVAVFQNGWGASLVGAEGVGAIISWLPLFLFVILFGLSMDYHVFVVSRIREARLQGRTNKDAITHGVVTTAGVVTSAAVIMVAVFAIFGTLSMQSFKQMGVGLAAAVLIDATAIRGILLPAVMALLGERNWYLPKWLHRLPDLTHDEVAAPPPPAVTDERVGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K303</accession>
    <name>A0A2M9K303_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NAD(P)-dependent oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_02195</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000001">
        <property type="protein sequence ID" value="PJN13407.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN13407">
        <property type="protein sequence ID" value="PJN13407"/>
        <property type="gene ID" value="CG723_02195"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016040">
        <property type="entry name" value="NAD(P)-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13460">
        <property type="entry name" value="NAD_binding_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD(P)-bd_dom" evidence="1">
        <location>
            <begin position="6"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN13407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="284" mass="29525" checksum="E4A0E27EFDA89B9E" modified="2018-04-25" version="1">MILITGATGTIGSEVTRLLATRGVPHRALTRDPARAAFGPATEVVRGDLDDPETLGAAVAGATAVFMVTLPGSGSGPGAQDKALLDAARAAGVHRVVKLSAIGTGEPGAGRFGMWHVPGEEALRAGDLEWTVLRPTTFASNFLWSAPEIRAGRPVPDQFADGAQGVIDPRDIAEAAVETLLADGHTGRVYTLTGPELLTVPDQAAAIAAAVGRPVETVEVPLESAREYVLAAGIAEESVDSVLEGFAYVRAGHNAIVTDDVERILGRPPRTFAMWAEEHKGAFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K305</accession>
    <name>A0A2M9K305_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">PAS sensor protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_02790</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000001">
        <property type="protein sequence ID" value="PJN13508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN13508">
        <property type="protein sequence ID" value="PJN13508"/>
        <property type="gene ID" value="CG723_02790"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07228">
        <property type="entry name" value="SpoIIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00331">
        <property type="entry name" value="PP2C_SIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="SSF81606"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PAS" evidence="2">
        <location>
            <begin position="34"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="69"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="237"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN13508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="822" mass="88108" checksum="AD60E5B4C7AE3EC0" modified="2018-04-25" version="1">MTLGRRAGKGAQAMHSGTGTAPQSPVPGRVPLAVVVVDESGLVSHWSTGARRLFGPAREDAVGRPATDLLPVSGVLPDGPNSEAYGEEGAYDGLGPGLESSLEGRASYPAAGRARLEAPRRERIDVLWWAYPLVGPGPEKLLVLAADAGRLHADDVPDGQPLERIAPGFALHTDFPGADELARGLPAILPSMSVGESARIVSQVLELGYPVLEFSLHDRVPVTADWGVPRRAERKARREEAARAAAAGLPAPRRAPDDDADDLEYAAVREHLEFLNEVSGRIGSSLDLSRTIIEVSRAVVPRFTDVAGTYLREQVVAGEGFPEGPPDATTLWHRVALEHTDEPGRWDDVVPVGESMPFPAHTPFFQCMTSGQPVLVPRITEEMGNAIASQFEKRDIRPLITDRSMLVVPLKARNVVLGFMILLRHRERPVFNDMDRVTGAELAARAGLVLDNARMYTYQESVAETLQDSMLPHIEPHMPGCDIATRYLPGTLLGRVGGDWFDSIKLPGSRTALVVGDVMGHGLNSAAMMGQLRTAVQTMAALDLPPAQLLRNLDDLAQRLGEHYLATCLYAVYDPIANELELANAGHIPPVLVRAEDGRSELLELPTGAPIGVGGVPFESVRVPMAPGDRLVMCTDGLVEVRGEDIGVGLATLCESAAHPAASMDAACDTIIRSLNTCGGRKDDVALLMARLNGIAPEDVAHWSVTPDPAEVPRTRALVRDQLTAWGLGALIAPAEMMAGELVANAVRHARTRSVEVRLVRSGALVCEVEDDDQRLPTLLNAGPGDEFGRGLRVVSALAREWGTSRTGSGKTVWFELALPRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K310</accession>
    <name>A0A2M9K310_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Adenylosuccinate lyase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CG723_02760</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000001">
        <property type="protein sequence ID" value="PJN13503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN13503">
        <property type="protein sequence ID" value="PJN13503"/>
        <property type="gene ID" value="CG723_02760"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004155">
        <property type="entry name" value="PBS_lyase_HEAT"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03130">
        <property type="entry name" value="HEAT_PBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00567">
        <property type="entry name" value="EZ_HEAT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="SSF48371"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PJN13503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="193" mass="20454" checksum="A4E519ADA5FBE3DA" modified="2018-04-25" version="1">MDEELRSVTERLRAESGASPLFDRIAATGDLDELAAVLTEPGQPLWARELAAYRLGAAGDRRAFEALVLLLNHRDPARCATAAHALAALGDPRTARAAAALATNELRVAYALHPVRLLAALRAPESAPALITTLERRLGPRDPYRAVALACVEGLGSLGDARARPALTAALAHPALAEAAVRALARLPEQRWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K3I6</accession>
    <name>A0A2M9K3I6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Acyl-CoA dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CG723_03855</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CB01635</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000001">
        <property type="protein sequence ID" value="PJN13685.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN13685">
        <property type="protein sequence ID" value="PJN13685"/>
        <property type="gene ID" value="CG723_03855"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016627">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="SSF47203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="SSF56645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0274">FAD</keyword>
    <keyword evidence="3 5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA_dh_N" evidence="8">
        <location>
            <begin position="12"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_M" evidence="7">
        <location>
            <begin position="130"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_1" evidence="6">
        <location>
            <begin position="237"/>
            <end position="385"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PJN13685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="385" mass="42179" checksum="3C38173ADA078856" modified="2018-04-25" version="1">MSELPIELVPLTPEQRDIVDLTRTFAREEIRPRGRAVDEADVETPWDLWRAAAKVGITGFMLPEEYGGGGFTDVFTQVLVQEELCVGDLGIGNLLCSNGFFADPVMELGTEEQKRAWLTPLAGADTPMTSLATTEPGSGSDAASIVTTATRTAGGYLLNGQKAWISNAGEAEQYVVFAKTDPTQRSRGVTAFLLRKGAEGLTFGEPMRKMGQRAIVCREVFFSDVFVPDVDRLGDEGQGFAGLMRTFDISRAVLGAAATGVARAAYEYARDYARTRVQFGKPIIEHQAVAFRLADMRTRIEQSRLMTWRAARRLDAGLDATAEAAMAKLTASETAAYCTWAAVQTLGGWGYSREFPVEQWMRDAKLEEIEEGTSDIMRLVISRSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K3M6</accession>
    <name>A0A2M9K3M6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Biotin transporter BioY</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CG723_00930</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000001">
        <property type="protein sequence ID" value="PJN13734.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN13734">
        <property type="protein sequence ID" value="PJN13734"/>
        <property type="gene ID" value="CG723_00930"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PJN13734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="384" mass="40349" checksum="4224040A7AC5BE8A" modified="2018-04-25" version="1">MTLLARDGGAPPAPQDRPSLTELRLSAFAAHRSARFPLGPLTLFAGPSGSGKSSALKAYEGLARLGGGAALDEVFPDPSAHVPDGARPDAQRRRGFRIGCTVTGPVGPVRLDLAIQAEPELRIVGERLTCGGRTLLETALRDPGRRVVQAAWHTAGATPVTRAPLPDDLLGTALLPLRVAGKTEGQRLVIAAAEQVVVALRSVFSCDPRPDRMRRPAPATADRLLSGCDNLAAVLWRTRSECGIRHALLVAAARAGCAGPVVDVLSEDLGNGTVRAVLDRGDGLRTPVDRLGDGELRYLALALVLLTGPRVLAVDPVAEVPEAYQTLTVLADGLDRSLDPRQLRELTALAVRMCGRGHIRLAGAVGDGTWAAREHGAAVVDLRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K3M7</accession>
    <name>A0A2M9K3M7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycogen debranching protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_00375</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000001">
        <property type="protein sequence ID" value="PJN13722.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN13722">
        <property type="protein sequence ID" value="PJN13722"/>
        <property type="gene ID" value="CG723_00375"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032856">
        <property type="entry name" value="GDE_N_bis"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14742">
        <property type="entry name" value="GDE_N_bis"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="SSF48208"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GDE_N_bis" evidence="2">
        <location>
            <begin position="15"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="193"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN13722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="646" mass="66819" checksum="FFAA03A0F5B0480C" modified="2018-04-25" version="1">MPPAHTALICVALPSLAISSQQGQLTGDGLEGFYRAGRRLLSRCLLRVAGREPVAVQARMVAADRARFVATLRPVVDGGPDPDIMVERTRHADGTERITLRSSATRPLRLPVEVALGTDLAELGAVAAGRPGRALSATVHDSGMRWSSPAGHAVVTADPPPRDALASAGLLRWEFDLPPGGTWSVELRVRSDGGGTGRPVGHGTARPLAGAEAAGDDARVGPLLRTCAEDLHALLLRDPGHPSDLYLAAGAPWRCGLAPAEALAAARMALPLGTRLAAGTLRALARTQLPGAGREAGTIPGPLRDAGPHLPPGCTGTEATLLFPALLAEARRWGLPEQEVAELLPTAERCLHWLRAAIGEGTYLADPGPGGPLRCETQAHAHRAALLGADLLDAHGRPGAVELRQWAEVLRTRFREDFWAEDRGGGRPAAARTPDGRLLPHLGSAAAHLLDTGLLGGGVMAPGLLDKVQIEQLARLLGGPALDSGWGLRSLGVREASYNPFGHRGGAVRVQETALAVGGLADAGYEKESSSLLRGVLSAAEAFGFRLPEMYAGEQRCEGGAPLPHPAACRPAATAAAAGVQILAALAGIRPDAPAGTVTLRPMRSAPLGEIGLAGLRVAGAPFSVRVSRLGLAMVEEAADGLQLGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JEW1</accession>
    <name>A0A2M9JEW1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">IS5/IS1182 family transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_44565</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000048">
        <property type="protein sequence ID" value="PJN05436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN05436">
        <property type="protein sequence ID" value="PJN05436"/>
        <property type="gene ID" value="CG723_44565"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025161">
        <property type="entry name" value="Put_IS4/IS5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002559">
        <property type="entry name" value="Transposase_11"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01609">
        <property type="entry name" value="DDE_Tnp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13340">
        <property type="entry name" value="DUF4096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDE_Tnp_1" evidence="1">
        <location>
            <begin position="102"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN05436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="272" mass="30574" checksum="70C74771E49ACD55" modified="2018-04-25" version="1">MTTRPWIVDDALWAVSEPLLSPWPERSPGPKPVPDRLCLQGILYVVHQDIAWQLLPLELGFGSGQTCWWRLDRWQQAGVFDELHRILLAKLSAVGELDWSRACVDGSHVRAKKGGAATGPSPVDRRKTGSKHHLICDGKGIPLHVVTTAANVNDITQTLALVDGIPPVAGRPGHPRRRPDAVLGDNAYDSRAIRRELRKRRIMPVISRKGVPNIKGLGKLRYVVEQTFALLHQFKRLAVRWERRLELHDAFVSLGCSLICWRRLRKAGSHPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JEZ0</accession>
    <name>A0A2M9JEZ0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">AURKAIP1/COX24 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_45070</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000050">
        <property type="protein sequence ID" value="PJN05382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003948845.1">
        <property type="nucleotide sequence ID" value="NZ_NNBL01000050.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN05382">
        <property type="protein sequence ID" value="PJN05382"/>
        <property type="gene ID" value="CG723_45070"/>
    </dbReference>
    <dbReference type="GeneID" id="58475053"/>
    <dbReference type="GeneID" id="63981800"/>
    <dbReference type="GeneID" id="67401552"/>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013177">
        <property type="entry name" value="COX24_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08213">
        <property type="entry name" value="DUF1713"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01155">
        <property type="entry name" value="DUF1713"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF1713" evidence="2">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN05382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="32" mass="4045" checksum="3DE18FA26371F5A9" modified="2018-04-25" version="1">MGSVIKKRRKRMAKKKHRKLLKRTRVQRRNKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JF93</accession>
    <name>A0A2M9JF93_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CG723_43970</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000045">
        <property type="protein sequence ID" value="PJN05565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN05565">
        <property type="protein sequence ID" value="PJN05565"/>
        <property type="gene ID" value="CG723_43970"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PJN05565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="59" mass="7196" checksum="2D1038B2791A7E95" modified="2018-04-25" version="1">MRSSARRTGRWWNRRRLARDYEAHPHRSEAMIHLTMINLMTRRLTAEFTPHVARRLNNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JFG2</accession>
    <name>A0A2M9JFG2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_43760</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000044">
        <property type="protein sequence ID" value="PJN05635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN05635">
        <property type="protein sequence ID" value="PJN05635"/>
        <property type="gene ID" value="CG723_43760"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014883501" evidence="1">
        <location>
            <begin position="36"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN05635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="206" mass="21834" checksum="7AB5210C4BCF1763" modified="2018-04-25" version="1">MLIRTRTRMRRVLPALAALVAAASGAAALTTPAAAAGTPRFLAPSELPPHPASAWFAGPVTAGQPDPLPMCVGEALPSTSVHRTYRTDYDTGALQVTVVERSVVRAKAFAALLRKDLAGCAKKVMEQDPETSAKQKYYGRLAVEEGAYVYGVHTTTTWGASDISLFSVGRDGNVVTVVQWGQMGSFADARVAAFKKTTVTAVNKLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JFL2</accession>
    <name>A0A2M9JFL2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_43480</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000043">
        <property type="protein sequence ID" value="PJN05674.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN05674">
        <property type="protein sequence ID" value="PJN05674"/>
        <property type="gene ID" value="CG723_43480"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014663948" evidence="1">
        <location>
            <begin position="28"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN05674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="58" mass="6152" checksum="92C8FF0D8E70DC4C" modified="2018-04-25" version="1">MVQTKKIGLFVVVVFVLYVIITDPAKAADYVQIGFEGVSSAAQSIGDFMTWVVNGGGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JFN9</accession>
    <name>A0A2M9JFN9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">SAM-dependent methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_43820</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000044">
        <property type="protein sequence ID" value="PJN05623.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN05623">
        <property type="protein sequence ID" value="PJN05623"/>
        <property type="gene ID" value="CG723_43820"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransf_11" evidence="1">
        <location>
            <begin position="47"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN05623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="248" mass="26825" checksum="3D7BFAE170E68CCB" modified="2018-04-25" version="1">MTITSQARSFDTAAASYAANRPSYPSELLDAVEELTGSPLKGARVADIGAGTGLATTLLRARGGSVIAVEPGPGMAAQFRLSLPDVPLVIGDGNNLPLASASIDVLTYAQAWHWTDQRKSVPEALRVLRPGGALALWWNDSDSTVPWIADQDARLRRLFGADDSPHDPTARFRELPPELGFGHRHVPWTRSVPLDMHLANLASYSDFLVLGKEATNTFIAKERDLLAKVFPNRMVEEHYVASLAVATC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JFX1</accession>
    <name>A0A2M9JFX1_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Glycerol kinase</fullName>
            <ecNumber evidence="5">2.7.1.30</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">ATP:glycerol 3-phosphotransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">Glycerokinase</fullName>
            <shortName evidence="5">GK</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5 9" type="primary">glpK</name>
        <name evidence="9" type="ORF">CG723_43010</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CB01635</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn-glycerol 3-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>ATP + glycerol = ADP + H(+) + sn-glycerol 3-phosphate</text>
            <dbReference type="Rhea" id="RHEA:21644"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17754"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57597"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.30"/>
        </reaction>
    </comment>
    <comment type="activity regulation">
        <text evidence="5">Inhibited by fructose 1,6-bisphosphate (FBP).</text>
    </comment>
    <comment type="pathway">
        <text evidence="5">Polyol metabolism; glycerol degradation via glycerol kinase pathway; sn-glycerol 3-phosphate from glycerol: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5 6">Belongs to the FGGY kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.30" evidence="5"/>
    <dbReference type="EMBL" id="NNBL01000042">
        <property type="protein sequence ID" value="PJN05703.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN05703">
        <property type="protein sequence ID" value="PJN05703"/>
        <property type="gene ID" value="CG723_43010"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00618">
        <property type="reaction ID" value="UER00672"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004370">
        <property type="term" value="F:glycerol kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019563">
        <property type="term" value="P:glycerol catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006072">
        <property type="term" value="P:glycerol-3-phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00186">
        <property type="entry name" value="Glycerol_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000577">
        <property type="entry name" value="Carb_kinase_FGGY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018485">
        <property type="entry name" value="Carb_kinase_FGGY_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018483">
        <property type="entry name" value="Carb_kinase_FGGY_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018484">
        <property type="entry name" value="Carb_kinase_FGGY_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005999">
        <property type="entry name" value="Glycerol_kin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02782">
        <property type="entry name" value="FGGY_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00370">
        <property type="entry name" value="FGGY_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000538">
        <property type="entry name" value="GlpK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01311">
        <property type="entry name" value="glycerol_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00445">
        <property type="entry name" value="FGGY_KINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 5" id="KW-0319">Glycerol metabolism</keyword>
    <keyword evidence="5 6 9" id="KW-0418">Kinase</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="FGGY_N" evidence="7">
        <location>
            <begin position="11"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="domain" description="FGGY_C" evidence="8">
        <location>
            <begin position="271"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="5">
        <location>
            <begin position="88"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="5">
        <location>
            <begin position="255"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="18"/>
            <end position="20"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="18"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="22"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="140"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="277"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="321"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="325"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="422"/>
            <end position="426"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PJN05703.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="514" mass="55692" checksum="F17B88AA74323A8B" modified="2018-04-25" version="1">MTDAHTAGPFIAAIDQGTTSSRCIVFDKDGRIVSVDQKEHEQIFPKPGWVEHNATEIWTNVQEVVAGAVTKAGITRDDIKAIGITNQRETTLLWDKNTGEPVHNAIVWQDTRTDALCKELGRNVGQDRFRRETGLPLASYFAGPKARWLLDNVEGLKERAEAGDILFGTMDSWVIWNLTGGVNGGKHVTDVTNASRTMLMNLHTMEWDAKIAESIGVPLAMLPEIRSSAEVYGEVSGGGLGDLLGGIPVASALGDQQAALFGQTCFSEGEAKSTYGTGTFLLMNTGDKPVNSYNGLLTTVGYRIGDQKAVYALEGSIAVTGSLVQWMRDQMGLISTAAEIETLASSVEDNGGAYFVPAFSGLFAPYWRSDARGVIAGLTRYVTKAHLARAVLEATAWQTREITDAMTKDSGVELAAIKVDGGMTSNNLLMQTLSDFVDAPVVRPMVAETTCLGAAYAAGLAVGFWSSTDELRANWRRAAEWTPNMAAEKRDREYKSWLKAVERSMGWLDESGEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JGA6</accession>
    <name>A0A2M9JGA6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DNA primase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CG723_42060</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000038">
        <property type="protein sequence ID" value="PJN05919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN05919">
        <property type="protein sequence ID" value="PJN05919"/>
        <property type="gene ID" value="CG723_42060"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004968">
        <property type="entry name" value="DNA_primase/NTPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006500">
        <property type="entry name" value="DNA_primase_phage/plasmid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045455">
        <property type="entry name" value="DUF5906"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014015">
        <property type="entry name" value="Helicase_SF3_DNA-vir"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014818">
        <property type="entry name" value="Phage/plasmid_primase_P4_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08706">
        <property type="entry name" value="D5_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19263">
        <property type="entry name" value="DUF5906"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03288">
        <property type="entry name" value="Pox_D5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00885">
        <property type="entry name" value="D5_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01613">
        <property type="entry name" value="primase_Cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51206">
        <property type="entry name" value="SF3_HELICASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SF3 helicase" evidence="4">
        <location>
            <begin position="211"/>
            <end position="370"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PJN05919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="501" mass="55567" checksum="FC952D7961E65752" modified="2018-04-25" version="1">MSARNNDTLFDFDAQAVASQILAHPVLPPRDEQGEGVVATAQGLLPDTLSDRGNAKLFVRLYARDYRHVPGLGWFRWDGTRWQVDEDDTVLWAAGDLAESLATGDPRGVFAPQALQQHRRRALSTSGMNAMLTQAKSAPGMVLNAARLDADPYALCTPSGVVDLRTGTIHRADPDKDFHSRSTTAAPLAMPTPRWDRFLRDTFGADPEGAEMIDFLHLLLGYSLTGDVGGQVMPFLFGSGKNGKSVLLDVLMKLIGDYADAAPPGFLMARPYEGHPTDLAELHGRRVIVCSEVKPGDRFDEARVKLLTGGDRIKARRMRQDFFSFQPTHKLWLLGNHRPEVGSGGFAFWRRMRLIPFERVVPDHRKIDNLADLLVTEEGPGILNWLIEGARRYLGGERDLTGPERVRIATSAYAETEDHTGRFLSESCRLDTELRAEQAWLYTAYKTWCQNEGAPPISSRAFAARVREVLGLASPKAMILSNQRKYYPGIGLTALADEERA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JGS1</accession>
    <name>A0A2M9JGS1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">IS200/IS605 family transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_41565</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000036">
        <property type="protein sequence ID" value="PJN06081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN06081">
        <property type="protein sequence ID" value="PJN06081"/>
        <property type="gene ID" value="CG723_41565"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1290">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002686">
        <property type="entry name" value="Transposase_17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036515">
        <property type="entry name" value="Transposase_17_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01797">
        <property type="entry name" value="Y1_Tnp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01321">
        <property type="entry name" value="Y1_Tnp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143422">
        <property type="entry name" value="SSF143422"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Y1_Tnp" evidence="1">
        <location>
            <begin position="18"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM01321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN06081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="143" mass="16729" checksum="181E35068872031E" modified="2018-04-25" version="1">MSPRWNPNPDVRTGRHVVYNLHVHLVFVTKYRRKAFTDAMLTRTEEIMRDVCTDFEAELKQFNGEQDHVHLLVHYPPKVQLSKLVNSLKGVSSRRLRQEYDNHVRRYLWGGHFWSGSYFAGSCGGTPLTVVKQYIENQQRPTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JH19</accession>
    <name>A0A2M9JH19_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Serine hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_40560</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000034">
        <property type="protein sequence ID" value="PJN06171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN06171">
        <property type="protein sequence ID" value="PJN06171"/>
        <property type="gene ID" value="CG723_40560"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001466">
        <property type="entry name" value="Beta-lactam-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00144">
        <property type="entry name" value="Beta-lactamase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Beta-lactamase" evidence="1">
        <location>
            <begin position="17"/>
            <end position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN06171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="463" mass="49764" checksum="EF0733F93EDA4BC0" modified="2018-04-25" version="1">MSELNELCGWLEGRLPELLAEHKVPAASIAVYAHGETIDRAAGVLNKNTGVEATADSVFQIGSITKVWTATLAMQLVDEGTLDIDVPVRAYLPAFTVGDETASAEITVRQLMCHTSGFEGDIFLDTGRGDDAVHKLVTLLADVPQLFAPGEMFSYNNAAFCVLGRIVEVLRDKSYDDCLRDHLFTPLGLTHVAPSPYEAVRFRAALGHLTPEQGVEPQPAHVWALPRSNAPAGSMLAMRPRDLVTFARMHLDGGRGPDGTAVLAPESALAMRHREVELPDLGLMGDAWGLGWSLFDWPGGAVVGHDGGTLGQSAFLRVAPEHDIAVALLTNGGNPLPLYVELVGRVLRELAGTEMPALPVPDADAPRVETARFVGTYASSVGDTVVSEDADGRLWAERTPKGVFAELDGGPPERIELVAYDGDRLIPVKPQRGMHMVHAFVGDDGTGRARFLHTGRADRRVSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-09-29" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JH55</accession>
    <name>A0A2M9JH55_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">LTD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CG723_40735</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000034">
        <property type="protein sequence ID" value="PJN06195.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN06195">
        <property type="protein sequence ID" value="PJN06195"/>
        <property type="gene ID" value="CG723_40735"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1260">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001322">
        <property type="entry name" value="Lamin_tail_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036415">
        <property type="entry name" value="Lamin_tail_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00932">
        <property type="entry name" value="LTD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74853">
        <property type="entry name" value="SSF74853"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51841">
        <property type="entry name" value="LTD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014883504" description="LTD domain-containing protein" evidence="2">
        <location>
            <begin position="37"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="domain" description="LTD" evidence="3">
        <location>
            <begin position="31"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="183"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="213"/>
            <end position="361"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PJN06195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="370" mass="37531" checksum="5B113F9DB108287A" modified="2018-04-25" version="1">MSSRSIRRMAAASLASGVALGAAALPASAQSSPHHAAAYRSGVVISGVQYDSPGFDDRSNYSLNREWIDVTNTSRHSVNLDGWRLSDEDGHTYTFEHFRLGGRSTVRVHTGIGRDTYRDVYQDRRNYVWDNRSDTATLRNDDGRFVDEVSWGGRHYRDRDGWRWGTFGGHHRNRDGWRWGDLGGHPRDAGHHGGVGGVHPGQHGPGGHQGQHGGQGGQGQNGPGGHQGHGGQNGQGGQGGQGQNGPGGHQGQGGQNGQGGSQGQGGQNGQGGSQGQGGQNGQGGQGQNGPGGHQGQGGQNGQGGSQGQGGQNGQGGQGQNGPGGHQGQGGQTGQGHAGQGGQGGQGGQGGQGGQGGQGGGQDQAGQGGRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JH56</accession>
    <name>A0A2M9JH56_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CG723_40065</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CB01635</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000033">
        <property type="protein sequence ID" value="PJN06219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN06219">
        <property type="protein sequence ID" value="PJN06219"/>
        <property type="gene ID" value="CG723_40065"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="33"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="98"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="128"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="172"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="271"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="94"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PJN06219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="310" mass="34585" checksum="02A386BB79BEDEAF" modified="2018-04-25" version="1">MTADIRTTSPAARGRSLAGGDRRGEHPRRRGRFGVHIFLMAVSLAFLAPLLLAVYASLRPYEETAQHGYFSLPEHLSFDYYREAFSDSGMGEYFKNTLIIAVPAVLITLFLASFVAFAVSRIKVRGGIVLLMFFTAGNLLPPQVLVTPLYVLFLKIPLPWWMSDSLTMYDSYWAVIIVNIGFQLGFCVFVLANFMRTLPQEILEAAIVDGAGLWTQFWRITLPLCRPALAALGTLEFTWVYNDFLWALIFISNPDKLPITSSLNNLRGQFFTDYNLLAAGSVLVALPTILVFLLLQRHFIAGLTLGSSKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JH75</accession>
    <name>A0A2M9JH75_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CG723_40045</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000033">
        <property type="protein sequence ID" value="PJN06215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN06215">
        <property type="protein sequence ID" value="PJN06215"/>
        <property type="gene ID" value="CG723_40045"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000600">
        <property type="entry name" value="ROK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18964">
        <property type="entry name" value="PTHR18964"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00480">
        <property type="entry name" value="ROK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01125">
        <property type="entry name" value="ROK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PJN06215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="315" mass="31656" checksum="728FFFB41DD807BB" modified="2018-04-25" version="1">MQTDLVAALDIGGTKIAGALVDDHGRILLRAQRPTPAKEDGDTVMRAVEDVLRELTAAPLWVRARAVGIGSAGPVDASTGTVSPVNVPGWRDFPLVDRVRAVTGGLPVDLVGDGVAMTAAEHWQGAAQGHDNALCMVVSTGVGGGLILGGKLHPGPTGNAGHIGHISVDLDGDSCPCGARGCVERIASGPNIARRALDGGWRPGADGDVSAAAVAAAARAGDKVAMASFERAAQALAAGIAATATLVEIDIAVIGGGVAKAGEVLFAPLRRSLRDYATLSFVQRLTVAPARMGTDAGLVGAAAAALTRDRDVSAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JHC3</accession>
    <name>A0A2M9JHC3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Protein in whiE locus</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_40375</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000033">
        <property type="protein sequence ID" value="PJN06274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN06274">
        <property type="protein sequence ID" value="PJN06274"/>
        <property type="gene ID" value="CG723_40375"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013096">
        <property type="entry name" value="Cupin_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016672">
        <property type="entry name" value="Polyketide_Synth_CurC_prd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07883">
        <property type="entry name" value="Cupin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016602">
        <property type="entry name" value="CurC_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cupin_2" evidence="2">
        <location>
            <begin position="41"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="117"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN06274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="159" mass="17178" checksum="E917BF57770D9861" modified="2018-04-25" version="1">MIKNPRIVDLSDTEPNRRRGGDLRAMLTPATVGSTSGFMGLALVQPGERIGEHYHPYSEEFVFVVNGALEVDLDGETYELRPDQGLLIPINVRHRFRNVGDVEARMVFHLGPLAPRPSLGHVDTEETEGAEAGPGFITGGPDLTAPGHGRPSERSGAIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JHE2</accession>
    <name>A0A2M9JHE2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Thioesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CG723_39830</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CB01635</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the thioesterase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000032">
        <property type="protein sequence ID" value="PJN06296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN06296">
        <property type="protein sequence ID" value="PJN06296"/>
        <property type="gene ID" value="CG723_39830"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901576">
        <property type="term" value="P:organic substance biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020802">
        <property type="entry name" value="PKS_thioesterase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012223">
        <property type="entry name" value="TEII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001031">
        <property type="entry name" value="Thioesterase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11487">
        <property type="entry name" value="PTHR11487"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00975">
        <property type="entry name" value="Thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00824">
        <property type="entry name" value="PKS_TE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PKS_TE" evidence="4">
        <location>
            <begin position="34"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="260"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PJN06296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="290" mass="31164" checksum="B930A60190E60668" modified="2018-04-25" version="1">MARAVRSGRMSTTGVTAAWYRCPVPRPAAQVRLMCFPHGGGSATAYWNWPALLPETVELHAVQYPGHTDRIAEPLHTDLHALADAAADAARPLLDRPVVLYGHSLGALAAYETARRLLAAGHPPLRLIVSGMPPPHRVRPGRVHLGSDRELIAELRRLEGVPDEVLAHPDLLDLVLRTARADYALAETYVQPAGPAPDLPLTVHRATGDPELTADEAADWTAATTGPVRHRTFSGGHFHLADEPAPVLLELVDDLVSDMSAPRRPSRPAWMGTTATAVPPRLAQGTGRPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JHZ8</accession>
    <name>A0A2M9JHZ8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CG723_38925</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CB01635</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000029">
        <property type="protein sequence ID" value="PJN06516.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN06516">
        <property type="protein sequence ID" value="PJN06516"/>
        <property type="gene ID" value="CG723_38925"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd16913">
        <property type="entry name" value="YkuD_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.440.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041280">
        <property type="entry name" value="Big_10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005490">
        <property type="entry name" value="LD_TPept_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038063">
        <property type="entry name" value="Transpep_catalytic_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17964">
        <property type="entry name" value="Big_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03734">
        <property type="entry name" value="YkuD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141523">
        <property type="entry name" value="SSF141523"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014851270" evidence="4">
        <location>
            <begin position="31"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="domain" description="Big_10" evidence="6">
        <location>
            <begin position="54"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="domain" description="YkuD" evidence="5">
        <location>
            <begin position="243"/>
            <end position="365"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF03734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF17964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PJN06516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="401" mass="43655" checksum="7D54F5B7A478384E" modified="2018-04-25" version="1">MRTTVRNAGATLAAVLTWAVVLTGVTGCTAAEDLLGKSRSPEDAIEVVPANGTKNVPADRTIEVKVPDGRLQSVKVVKLQDGEEVPVQGRIDEHGARWRPTGERRLSLAAKYTVDVVARDEDGHRTARHTTFTTSVPAKRFVGYVTPEDRSTVGTGMIVSLVFNRDIQNRAAVERAIHITTKPAVEVAPHWFGKSRLDFRPRDYWKPGTEVTVDLGLRDVQSAPGVYGVQHKKMAFTIGRSQVSLVDADEDTMEVRREGEPAETIPITAGAAKTPTYNGKMVISEMFEMTRMDSRTVGFGGEYNVPDVPHAIRLTSSGTFLHGNYWTSDAFGNRNISHGCIGLADERGGSSDSPAGWFFDHSLVGDVIEVVNSKDKVVAPDNGLSGWNMTWKNWTAGTAAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JI49</accession>
    <name>A0A2M9JI49_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="11">ABC transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CG723_38955</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000029">
        <property type="protein sequence ID" value="PJN06522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN06522">
        <property type="protein sequence ID" value="PJN06522"/>
        <property type="gene ID" value="CG723_38955"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221">
        <property type="entry name" value="PTHR24221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="SSF90123"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="40"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="77"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="150"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="178"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="260"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="294"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="10">
        <location>
            <begin position="42"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="9">
        <location>
            <begin position="361"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="597"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="603"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="398"/>
            <end position="405"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PJN06522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="626" mass="66522" checksum="34C747055562439B" modified="2018-04-25" version="1">MPTTHAPATDPDQLAPAAEQSAVRTLLRLWPYVRPVRARWGGAAVVAVVASCLSLVFPIVLKWIVDGPVTDHDPGGVWLGAGMLLALGVAEALLFGLRRWLVARPLASVEAAMRADLYRHLQRLPVAFHDRWASGQLLSRGTTDLMVVRMFLAFPLTFLIVNGVTIAAGFVLLVAQDWGLGLVLLAPALPLMVLCYRFESKYASAARRAQDQVGDLTTVVEESVLGIRIIKGFGRHRSQARAFRDLSRTLRGTELAKARLLAGILGVITLLPEVALGAALVLGSVQVADGKLSAGTLVAFLSTALALRWPIDSIGFLLAMSQEAATATRRFFEVMDEPEESEDVPAAGGPVEEGAGGAGGLRFEGVRFRYPDAPEGSEPVLERIDLQVRSGETMALVGATGSGKTTLTALVPRLHELTGGRITLDGRDIASMGREELRTLVSVAFEEPTLFSASVAENVLMGAGEADVSKLDRALGVAQAGFVKSLPDGAGTQVGEQGLSLSGGQRQRLALARAVVGSPRFLVLDDPLSALDVHTEALVEAALREVLAASTALVVAHRPSTVLLADRVALLSDGRITAVGTHQELLRANAEYRHLMSGADLETEEDRDIDDDPESDEDGPEGKGTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JI70</accession>
    <name>A0A2M9JI70_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Phosphoenolpyruvate carboxykinase [GTP]</fullName>
            <shortName evidence="8">PEP carboxykinase</shortName>
            <shortName evidence="8">PEPCK</shortName>
            <ecNumber evidence="8">4.1.1.32</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">GTP-dependent phosphoenolpyruvate carboxykinase</fullName>
            <shortName evidence="8">GTP-PEPCK</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">pckG</name>
        <name evidence="11" type="ORF">CG723_38450</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CB01635</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>GTP + oxaloacetate = CO2 + GDP + phosphoenolpyruvate</text>
            <dbReference type="Rhea" id="RHEA:10388"/>
            <dbReference type="ChEBI" id="CHEBI:16452"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="EC" id="4.1.1.32"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="8">Binds 1 Mn(2+) ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="8">Carbohydrate biosynthesis; gluconeogenesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the phosphoenolpyruvate carboxykinase [GTP] family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.32" evidence="8"/>
    <dbReference type="EMBL" id="NNBL01000028">
        <property type="protein sequence ID" value="PJN06581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN06581">
        <property type="protein sequence ID" value="PJN06581"/>
        <property type="gene ID" value="CG723_38450"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00138"/>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004613">
        <property type="term" value="F:phosphoenolpyruvate carboxykinase (GTP) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00819">
        <property type="entry name" value="PEPCK_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.449.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.228.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00452">
        <property type="entry name" value="PEPCK_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018091">
        <property type="entry name" value="PEP_carboxykin_GTP_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013035">
        <property type="entry name" value="PEP_carboxykinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008209">
        <property type="entry name" value="PEP_carboxykinase_GTP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035077">
        <property type="entry name" value="PEP_carboxykinase_GTP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035078">
        <property type="entry name" value="PEP_carboxykinase_GTP_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008210">
        <property type="entry name" value="PEP_carboxykinase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11561">
        <property type="entry name" value="PTHR11561"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00821">
        <property type="entry name" value="PEPCK_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17297">
        <property type="entry name" value="PEPCK_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001348">
        <property type="entry name" value="PEP_carboxykinase_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF68923">
        <property type="entry name" value="SSF68923"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00505">
        <property type="entry name" value="PEPCK_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 8" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="8" id="KW-0312">Gluconeogenesis</keyword>
    <keyword evidence="5 8" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="11" id="KW-0418">Kinase</keyword>
    <keyword evidence="7 8" id="KW-0456">Lyase</keyword>
    <keyword evidence="6 8" id="KW-0464">Manganese</keyword>
    <keyword evidence="2 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PEPCK_N" evidence="10">
        <location>
            <begin position="24"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="domain" description="PEPCK_GTP" evidence="9">
        <location>
            <begin position="260"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="8">
        <location>
            <begin position="235"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="8">
        <location>
            <begin position="401"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="288"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="83"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="244"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="264"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="286"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="287"/>
            <end position="292"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="311"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="403"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="434"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="529"/>
            <end position="532"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF17297"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PJN06581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="620" mass="68296" checksum="30DA92997A8FED37" modified="2018-04-25" version="1">MARDIAAPVSLGTVPTKHQELISWVNEIAELTQPARVVWCDGSEAEYDRLAEELVDKGTFKKLDPIKRPNSYYAASDPTDVARVEDRTFICSEKEQDAGPTNHWKAPAEMRAIFTGEGNGLRGDEGDGGIFRGSMKGRTMYVVPFCMGPLGSDLSAIGVEITDSAYVAVSMRTMTRMGQPVLDELGTDGFFVKAVHTLGAPLEEGQQDVPWPCNSTKYISHFPETREIWSYGSGYGGNALLGKKCYALRIASVMARDEGWLAEHMLILKLTPPHGESKYVAAAFPSACGKTNLAMLEPTISGWTVETIGDDIAWMRFGEDGRLYAINPEAGFFGVAPGTGEHTNANAMKTLWGNSVFTNVALTDDNDIWWEGMTEETPAHLTDWKGNDWTPESGVPAAHPNARFTTPASQCPIIAPEWEDPKGVPISAILFGGRRASAVPLVTESFDWNHGVFLGANVASEKTAAAEGKVGELRRDPFAMLPFCGYNMGDYMAHWVDVAKDKDQAKLPKIYYVNWFRKNDAGKFVWPGFGENSRVLKWIVERLEGKAEGVESPIGILPTRDSLDTDGLELADSDLDFLLTVDKEVWRDEASLVPEHLNTFGDHTPKELWDEYRALVKRLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JIR3</accession>
    <name>A0A2M9JIR3_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA helicase</fullName>
            <ecNumber evidence="3">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">recQ</name>
        <name evidence="13" type="ORF">CG723_37490</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">CB01635</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O = ADP + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the helicase family. RecQ subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="3"/>
    <dbReference type="EMBL" id="NNBL01000026">
        <property type="protein sequence ID" value="PJN06775.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN06775">
        <property type="protein sequence ID" value="PJN06775"/>
        <property type="gene ID" value="CG723_37490"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043138">
        <property type="term" value="F:3'-5' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009432">
        <property type="term" value="P:SOS response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004589">
        <property type="entry name" value="DNA_helicase_ATP-dep_RecQ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006293">
        <property type="entry name" value="DNA_helicase_ATP-dep_RecQ_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010997">
        <property type="entry name" value="HRDC-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002121">
        <property type="entry name" value="HRDC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044876">
        <property type="entry name" value="HRDC_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032284">
        <property type="entry name" value="RecQ_Zn-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018982">
        <property type="entry name" value="RQC_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00570">
        <property type="entry name" value="HRDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16124">
        <property type="entry name" value="RecQ_Zn_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09382">
        <property type="entry name" value="RQC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00341">
        <property type="entry name" value="HRDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00956">
        <property type="entry name" value="RQC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47819">
        <property type="entry name" value="SSF47819"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01389">
        <property type="entry name" value="recQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00614">
        <property type="entry name" value="recQ_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50967">
        <property type="entry name" value="HRDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6 13" id="KW-0347">Helicase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="11">
        <location>
            <begin position="44"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="12">
        <location>
            <begin position="233"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="domain" description="HRDC" evidence="10">
        <location>
            <begin position="553"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="521"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="629"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="521"/>
            <end position="549"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PJN06775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="666" mass="72328" checksum="EBF4A4C892F54CDD" modified="2018-04-25" version="1">MNGIGGMSEVTEPGVATAMRGGALETLHRVFGYDAFRGEQEAIIDHVVDGGDAVVLMPTGGGKSLCYQIPALVRPGTGVVISPLIALMQDQVDALRALGVRAGFMNSTQDFDERRTVEAEFLAGELDVIYLAPERLRLDSTLDLLSRGRISVFAIDEAHCVAQWGHDFRPDYLALSVLGRRWPDVPRIALTATATHATHQEITERLGMPDAKHFVASFDRPNIQYRIVPKADPKKQLLSFLKQEHEGDAGIVYCLSRKSVEAAAEFLSRNGIEAVPYHAGLDAGTRAAHQSRFLREEGLVVCATIAFGMGIDKPDVRFVAHLDLPKSVEGYYQETGRAGRDGLASTAWMAYGLQDVVQQRKLINMGEGDEAFRRRAGSHLDAMLALCETAQCRRSQLLMYFGQEPQAASCGNCDTCLSPPETWDGTVAAQKILSTVVRLDRERRQKFGAGQVIDILMGRRTAKVIQFDHDQLSVFGIGEDLSEAEWRGVARQLLAQGLIAVEGEYGTLVLTEESGSVLGRRREVRLRKEAPRPATSRSASRDRKTKSPAADLPEQLLPVFEALRAWRGAQAKENGVPAYVIFHDATLKEIALQHPTSIGQLGTIGGVGEKKLATWGEGVLGVLAGLDGAGSGGGSAPTASATATEAAPEEHWPEHEPEPEPDDIDW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JIY4</accession>
    <name>A0A2M9JIY4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CG723_36710</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000025">
        <property type="protein sequence ID" value="PJN06828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN06828">
        <property type="protein sequence ID" value="PJN06828"/>
        <property type="gene ID" value="CG723_36710"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PJN06828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="292" mass="31288" checksum="E022097C187693FD" modified="2018-04-25" version="1">MSESAEVGPGRVRQMWHLVEPLHAVLYYAPEAFEEAAGLGFRTDERWPSYFAWRAAPLGAAGPTRVASAFYSFNPDMVAEHVPAAWRTAAPDAVLAGRLRSVDRAYRTLFGERLDGPEFAEAAALARRAADAVNAEGRPLAAANAELPWPEAPHLVFWQAATVLREHRGDGHLAALLAAGLDPVEALVSFAAVGAASARTFTSRGWSQDQWDAARERLAARGLLDETGSATEDGKALRAEVEERTDELAAAPWRTLGATDTARLSDLLGPLWVEVLGSGLLPSETTLGIGKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JJ58</accession>
    <name>A0A2M9JJ58_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Transcriptional regulator WhiB</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">whiB</name>
        <name evidence="13" type="ORF">CG723_37110</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">CB01635</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Acts as a transcriptional regulator. Probably redox-responsive. The apo- but not holo-form probably binds DNA.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="11">Binds 1 [4Fe-4S] cluster per subunit. Following nitrosylation of the [4Fe-4S] cluster binds 1 [4Fe-8(NO)] cluster per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="11">The Fe-S cluster can be nitrosylated by nitric oxide (NO).</text>
    </comment>
    <comment type="PTM">
        <text evidence="11">Upon Fe-S cluster removal intramolecular disulfide bonds are formed.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the WhiB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000025">
        <property type="protein sequence ID" value="PJN06899.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN06899">
        <property type="protein sequence ID" value="PJN06899"/>
        <property type="gene ID" value="CG723_37110"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035731">
        <property type="term" value="F:dinitrosyl-iron complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01479">
        <property type="entry name" value="WhiB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034768">
        <property type="entry name" value="4FE4S_WBL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003482">
        <property type="entry name" value="Whib"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38839">
        <property type="entry name" value="PTHR38839"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02467">
        <property type="entry name" value="Whib"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51674">
        <property type="entry name" value="4FE4S_WBL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 11" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8 11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 11" id="KW-0408">Iron</keyword>
    <keyword evidence="6 11" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="4 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 11" id="KW-0804">Transcription</keyword>
    <keyword evidence="7 11" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="4Fe-4S Wbl-type" evidence="12">
        <location>
            <begin position="24"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="25"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="48"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="51"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="57"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51674"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PJN06899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="87" mass="9928" checksum="49B232B32B84F759" modified="2018-04-25" version="1">MTESFQQLLVEDAEEELGWQERALCAQTDPESFFPEKGGSTREAKKVCLACEVRSECLEYALANDERFGIWGGLSERERRRLKKAAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-09-29" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JJB4</accession>
    <name>A0A2M9JJB4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CG723_36125</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CB01635</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000024">
        <property type="protein sequence ID" value="PJN06932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN06932">
        <property type="protein sequence ID" value="PJN06932"/>
        <property type="gene ID" value="CG723_36125"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="53"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="87"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="159"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="185"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="237"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="270"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="302"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="327"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="364"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="396"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="15"/>
            <end position="420"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PJN06932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="438" mass="46275" checksum="97B246B9127E6058" modified="2018-04-25" version="1">MTPQVDIPAATLRRTTLAAAIGNTVETYDYAVYGFLATVLAKAFFPASTPETALLSSFAVFGSAFLARPAGALVFGPIADRLGRRPALVASLLLMAAVSTLIGVLPSTATIGIAAPVLLVLLRFAQGLAGGGEYTTAIIYVAEFAPPHRRGALSSRVQVGSLAGLLIGAVVVLFLNAALTHDQMLAWGWRVPFLLALPIGAIGLYLRSRFGETPEFLAARNEPSQQDVKVTDQWARVFLLVGVSVLHIIGFYMTYTYVQSYLIRLRLSPFTATSVIAFALLIGLFLVIAGGRASDRKGRSRVLLATSLTVLIVTYPLFAVLSTAPPLWLVIVCTVLLSAGPAFYSGIAPITYVQLIPVRRRGSVVAVAYNIAVAALGGSAVFICQVLVQLTGDSRSPAYLLLAAATVSAIAAFALTRRTRRHLQPSPSPMSLSAEASS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JK35</accession>
    <name>A0A2M9JK35_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Apolipoprotein N-acyltransferase</fullName>
            <shortName evidence="8">ALP N-acyltransferase</shortName>
            <ecNumber evidence="8">2.3.1.269</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8 11" type="primary">lnt</name>
        <name evidence="11" type="ORF">CG723_35160</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CB01635</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the phospholipid dependent N-acylation of the N-terminal cysteine of apolipoprotein, the last step in lipoprotein maturation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>a glycerophospholipid + N-terminal S-1,2-diacyl-sn-glyceryl-L-cysteinyl-[lipoprotein] = a 2-acyl-sn-glycero-3-phospholipid + H(+) + N-acyl-S-1,2-diacyl-sn-glyceryl-L-cysteinyl-[lipoprotein]</text>
            <dbReference type="Rhea" id="RHEA:48228"/>
            <dbReference type="Rhea" id="RHEA-COMP:14681"/>
            <dbReference type="Rhea" id="RHEA-COMP:14684"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:136912"/>
            <dbReference type="ChEBI" id="CHEBI:140656"/>
            <dbReference type="ChEBI" id="CHEBI:140657"/>
            <dbReference type="ChEBI" id="CHEBI:140660"/>
            <dbReference type="EC" id="2.3.1.269"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="8">Protein modification; lipoprotein biosynthesis (N-acyl transfer).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the CN hydrolase family. Apolipoprotein N-acyltransferase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.269" evidence="8"/>
    <dbReference type="EMBL" id="NNBL01000022">
        <property type="protein sequence ID" value="PJN07231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN07231">
        <property type="protein sequence ID" value="PJN07231"/>
        <property type="gene ID" value="CG723_35160"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00666"/>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016410">
        <property type="term" value="F:N-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042158">
        <property type="term" value="P:lipoprotein biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07571">
        <property type="entry name" value="ALP_N-acyl_transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01148">
        <property type="entry name" value="Lnt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004563">
        <property type="entry name" value="Apolipo_AcylTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003010">
        <property type="entry name" value="C-N_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036526">
        <property type="entry name" value="C-N_Hydrolase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045378">
        <property type="entry name" value="LNT_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00795">
        <property type="entry name" value="CN_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20154">
        <property type="entry name" value="LNT_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56317">
        <property type="entry name" value="SSF56317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00546">
        <property type="entry name" value="lnt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50263">
        <property type="entry name" value="CN_HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8 11" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="2 8" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="11" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8 11" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="62"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="118"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="151"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="191"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="227"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="domain" description="CN hydrolase" evidence="10">
        <location>
            <begin position="254"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="544"/>
            <end position="564"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PJN07231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="564" mass="59606" checksum="228CA95FBC618978" modified="2018-04-25" version="1">MDGSGGNGRSRSSSTTQAWPVSAVPASWTAPAASWQGIAPRLAASPWWRGVAAVSAGALPALAFPAPSLWWLAYVALVPWMLLARSAPTPRRAALDGWLGGLGFMLSVHHWLLPSLHVFTVVIAALLGALWAPWGRLLRRLLGGTPTRGQAAAALVAVPSAWLMVELVRSWQGLGGPWGLIGSSQWQVQPALRVASVGGVWLVSLLVVAVNTAITVLLVARSARTPAVAGLLVTATVTTVSWAWAPRPEPDGPVRVAVVQPGPIGGADSGEKRFDREEELTRGLAGQGVDLVVWGESSVGFDFSQRPDLARRLAALSREVGADILVNVDARRVSPGGAPGIFKSSVLVGPDGLTGQRYDKMRLVPFGEYIPARALLGWATSVGKAAGEDRVSGTRQVVMDARSARDSDLRIGPLVCFESAFPDMTRRLTRDGAQVLLAQSSTSTFQHSWAPEQHASLAAVRAAETGRPMVHATLTGVSAVYGPDGSRVGPWLGTSASAARVYEVPTAHGTTLYVRFGDWPVHAAVTVLALLGASEAVRQFRRRTAAPHVRPARTAHASPARPWH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JKF5</accession>
    <name>A0A2M9JKF5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_34425</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000021">
        <property type="protein sequence ID" value="PJN07348.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN07348">
        <property type="protein sequence ID" value="PJN07348"/>
        <property type="gene ID" value="CG723_34425"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="122"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN07348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="146" mass="15938" checksum="6B800019CFAA8F1D" modified="2018-04-25" version="1">MQNVKRPGRPARSRQQPAIEPEPEGVEPADTGIDAFDEYDTFEMYRVFCPDCAQPIALLADEDALPEHALCASPWNPFGLTVCAGTGRPAADARPADDSTEVQEQDTALLLTLPQGLDWRMQPFSHVGGPGSRPLRVPEQVRRTAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JL54</accession>
    <name>A0A2M9JL54_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">PadR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CG723_33100</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000019">
        <property type="protein sequence ID" value="PJN07604.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN07604">
        <property type="protein sequence ID" value="PJN07604"/>
        <property type="gene ID" value="CG723_33100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005149">
        <property type="entry name" value="Tscrpt_reg_PadR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03551">
        <property type="entry name" value="PadR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PadR" evidence="3">
        <location>
            <begin position="12"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="182"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="126"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="207"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PJN07604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="226" mass="25821" checksum="E779802E8786DD40" modified="2018-04-25" version="1">MSRRSGILEFAVLGLLRESPMHGYELRKRLNTSLGVFRAFSYGSLYPCLKTLVASGWLIEEPGSTPEDALAAPLAGRRAKIVYRLTAEGKEHFEDLLSQTGPDAYEDEHFAARFAFFGQTSRDVRMRVLEGRRSRLEERLEKMRISFARTRERLDDYTLELQRHGMESVEREVRWLNELIESERAGRDQRRSDPSDAAQQDTSGETGGLPRHRDSTRPDPSDDTAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JLL3</accession>
    <name>A0A2M9JLL3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF1844 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_32355</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000018">
        <property type="protein sequence ID" value="PJN07764.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN07764">
        <property type="protein sequence ID" value="PJN07764"/>
        <property type="gene ID" value="CG723_32355"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014995">
        <property type="entry name" value="DUF1844"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08899">
        <property type="entry name" value="DUF1844"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="101"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN07764.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="120" mass="12606" checksum="1143840544713151" modified="2018-04-25" version="1">MNDATPAAENTDYDALTRDIAEVPAVEVIVTVAVNLMSAAAVKLGLTEEGDAHKDLDEARKLVHALAGLLDASTTEISSFHAAPLRDGLKSLQLAFREASFVPDEPGQGPGEKYTGPVYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JLM8</accession>
    <name>A0A2M9JLM8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">LysR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_32425</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LysR transcriptional regulatory family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000018">
        <property type="protein sequence ID" value="PJN07775.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN07775">
        <property type="protein sequence ID" value="PJN07775"/>
        <property type="gene ID" value="CG723_32425"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005119">
        <property type="entry name" value="LysR_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000847">
        <property type="entry name" value="Tscrpt_reg_HTH_LysR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00126">
        <property type="entry name" value="HTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03466">
        <property type="entry name" value="LysR_substrate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00039">
        <property type="entry name" value="HTHLYSR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50931">
        <property type="entry name" value="HTH_LYSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH lysR-type" evidence="2">
        <location>
            <begin position="23"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN07775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="313" mass="32605" checksum="30786992C7D33158" modified="2018-04-25" version="1">MSGDTAGAADGSTTGAGLAHRVPDLGALELLLAVARLGSLGRAAREMGITQPAASSRIRSMERQLGVALVDRSPRGSRLTDAGALVTDWARRIVEAAAAFDVGAQALRDRRDSRLRVAASMTIAEYLLPNWLLALRAERPDTAVSLHAGNSAAVAERLLSGDADLGFVEGLAVPAGLDATVIAHDRLIVVTAPGHPWARRRKPLAADELAATPLILRERGSGTRQVLDAALGGLARPLIELSSTTAVKAAAVSGAGPSVLSELAVGEELAARRLVEIPLEGVRLRRDLRAVWPTGHRPVGPARELLALTRGPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JMF3</accession>
    <name>A0A2M9JMF3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">PA-phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_30210</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000016">
        <property type="protein sequence ID" value="PJN07977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN07977">
        <property type="protein sequence ID" value="PJN07977"/>
        <property type="gene ID" value="CG723_30210"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036938">
        <property type="entry name" value="P_Acid_Pase_2/haloperoxi_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000326">
        <property type="entry name" value="P_Acid_Pase_2/haloperoxidase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01569">
        <property type="entry name" value="PAP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00014">
        <property type="entry name" value="acidPPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48317">
        <property type="entry name" value="SSF48317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="169"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="195"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="domain" description="acidPPc" evidence="2">
        <location>
            <begin position="97"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN07977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="231" mass="24472" checksum="6B607CA9AA44381A" modified="2018-04-25" version="1">MPPSPAHSPRRESMPFWPAVSVLAVCGVLLGTLVAAVATRASPFALDTALHAWMLDHRPAWARQLAVIVTDTGSGAPAYVLAALAGTLAQRTVYGRGALTGVLALASAQVSRMALASALARPRPPAADWAAKASGWSMPSGHTTTSMVVALLFTLAVHRRVHGRGRPFLLAAPGIWATTVGLTRIYLGMHWPTDVAAGWLLAGCWAASATLLVLLWRRRADHALSMERQHT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JMP6</accession>
    <name>A0A2M9JMP6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CG723_29490</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000015">
        <property type="protein sequence ID" value="PJN08141.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08141">
        <property type="protein sequence ID" value="PJN08141"/>
        <property type="gene ID" value="CG723_29490"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018317">
        <property type="entry name" value="QueC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06508">
        <property type="entry name" value="QueC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PJN08141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="443" mass="49481" checksum="8476FC3E538D32EB" modified="2018-04-25" version="1">MTTDTPAFHFWLPDPGAPAPDPGWQPLSDALYWESPTRAPDRRHLLAPAPDWADDLQRVARAVFAADRCTSREETFDHWTRHIRLSVPVTAPDAWTRALPHLTALLATVTGDRWEVEFRPYDADARPRRRPLPFDPEGYAREVALFSGGLDSLGWAAQRATVHSPHALLLVTFEERNFESLQDTVYEAVFRRRERDLRRLEQSQTVRKPKGAAFTLERSTRSRGLLYAATAVHAAAAERVPVVHVPENGQLALNPPLSAARWGACSTRSVHPWTLHHLNRVIELIADRPERVVQVVNPFAALTKGEVCEAARDAGLPREVAEATLSCGSSPMRQPGRSRLRRVPHCGLCFPCLVRRSGLLHAYGGDRTPYAADPWDPSLDTDLAQHWRALTRWLDTPCTVLDLVADVPLPPDVRPAELLAVVENGREELRAFVAEAPAVRRTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JMY9</accession>
    <name>A0A2M9JMY9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">TIGR00374 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CG723_29980</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CB01635</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000015">
        <property type="protein sequence ID" value="PJN08231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08231">
        <property type="protein sequence ID" value="PJN08231"/>
        <property type="gene ID" value="CG723_29980"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022791">
        <property type="entry name" value="L-PG_synthase/AglD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03706">
        <property type="entry name" value="LPG_synthase_TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="105"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="143"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="248"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="272"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="669"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="700"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="777"/>
            <end position="799"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="811"/>
            <end position="832"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="861"/>
            <end position="881"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="944"/>
            <end position="962"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="573"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="29"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="586"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="610"/>
            <end position="625"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PJN08231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="971" mass="103530" checksum="0D89538EB693D766" modified="2018-04-25" version="1">MIRDQEETTEQQGVHPDKAEGTSGASARPDGEEADHSPLTERRGHRAAAPRADVPAKTAEAGPGRTEAPLVDPECIDADAHAERVDGDEPLLPARVHRPSDLMRLLVGVLAIAVLLSIAAFAHGTTSGLQQDISKGTGAAPDLMIKFAGLASSIAILLVPVAFAIERLIKRDGLRIADGVLAAVLAHGVTLATDLWVAQGAPSSIQDALTRPSPGDIHALTDPVHGYLAPVIAYMTAVGMSRRPRWRVVLWVVLLLDAFAMLVTGYTTPFSIILTVLIGWTVAYGTLYAVGSPNVRPTGQTLLAGLRHVGFHPVSAAREEAHESTTENGDRGRRYFVTLEDGPPLDVTIVDREQQAQGFFYRVWRQLTLRGITTGRSLQSLRQALEQEALLAYAAIAAGANAPKLIATSELGPDAVMLVYEHTGGRSLDSVPDEEITDALLRDTWHQVQALQSRRIAHRRLTGDAILVDRSGTVILTDLRGGEIASGDLILRMDIAQLLATLGLRVGAERAVASAVGVLGPDAIADCLPLLQPIALSRNTRSTLRRLGRERSEREREAVLEASRRAKQARLDEATQAAASLAGASPAEKSTPTETIAEQAAPPTAKTSAKAERQTEKAERQAEKKAIDEALDEAREEDLLTQIRHQVLRIRPQAPVEPARLERVKPRTLVSFIAGAIGAYFLLSQLTHIEFGTLFREAQWGWVAAAVLFSALSYFAAAMSLLGFVPERVPFMRTVAAQVAGSFVKIVAPAAVGGVALNTRFLQRSGVRPGLAVASVGASQLFGLGAHIMMLLTFGYLTGTEKTPSLSPSRTVIAGLLTVAVLVLVVTSIPFLRKFVVTRVRSLFAGVVPRMLDVLQRPQKLLTGIGGMLLLTACFVMCLDASIRAFGDETTTLSLASVAVVFLAGNALGSAAPTPGGVGAVEATLTVGLIAVGLPKEVAAPAVLLYRLMTLWLPVLPGWLFFNHLSRKGSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JN63</accession>
    <name>A0A2M9JN63_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Transcriptional regulator WhiB</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">whiB</name>
        <name evidence="13" type="ORF">CG723_28215</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">CB01635</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Acts as a transcriptional regulator. Probably redox-responsive. The apo- but not holo-form probably binds DNA.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="11">Binds 1 [4Fe-4S] cluster per subunit. Following nitrosylation of the [4Fe-4S] cluster binds 1 [4Fe-8(NO)] cluster per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="11">The Fe-S cluster can be nitrosylated by nitric oxide (NO).</text>
    </comment>
    <comment type="PTM">
        <text evidence="11">Upon Fe-S cluster removal intramolecular disulfide bonds are formed.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the WhiB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000014">
        <property type="protein sequence ID" value="PJN08290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08290">
        <property type="protein sequence ID" value="PJN08290"/>
        <property type="gene ID" value="CG723_28215"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035731">
        <property type="term" value="F:dinitrosyl-iron complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01479">
        <property type="entry name" value="WhiB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034768">
        <property type="entry name" value="4FE4S_WBL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003482">
        <property type="entry name" value="Whib"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38839">
        <property type="entry name" value="PTHR38839"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02467">
        <property type="entry name" value="Whib"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51674">
        <property type="entry name" value="4FE4S_WBL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 11" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8 11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 11" id="KW-0408">Iron</keyword>
    <keyword evidence="6 11" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="4 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 11" id="KW-0804">Transcription</keyword>
    <keyword evidence="7 11" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="4Fe-4S Wbl-type" evidence="12">
        <location>
            <begin position="29"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="30"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="52"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="55"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="61"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51674"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PJN08290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="131" mass="14449" checksum="5C72CF57C97F84AD" modified="2018-04-25" version="1">MPLPPWGSLDSGEDGAGMGWVTDWSAQAACRTTDPDELFVQGAAQNRAKAVCTGCPVRTECLADALDNRVEFGVWGGMTERERRALLRRRPTVTSWRRLLETARTEYERGAGLLPVDIDDDATYERYAAVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JN80</accession>
    <name>A0A2M9JN80_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_28360</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000014">
        <property type="protein sequence ID" value="PJN08310.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08310">
        <property type="protein sequence ID" value="PJN08310"/>
        <property type="gene ID" value="CG723_28360"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="78"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN08310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="116" mass="11736" checksum="D5B854CA842EE071" modified="2018-04-25" version="1">MPPIETDHVIAATGFRASCGRTGMLAPALPAGFGAGAQATPRVGSGFESRRPGVFLAGLMTAADSGPSMRFVHGASFTVPQLADGDRRRPRGGRPSGGLTLPGSRSAHAPPATADR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JND5</accession>
    <name>A0A2M9JND5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_28755</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000014">
        <property type="protein sequence ID" value="PJN08376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08376">
        <property type="protein sequence ID" value="PJN08376"/>
        <property type="gene ID" value="CG723_28755"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019660">
        <property type="entry name" value="Put_sensory_transdc_reg_YbjN"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10722">
        <property type="entry name" value="YbjN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN08376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="179" mass="20325" checksum="23F765584B60F6DD" modified="2018-04-25" version="1">MSIDPSSIPNFGGQPEQPQGSGPAGPVVPDQDLVKQLLEQMELKYVLDEEGDLAAPWEEFRTYFMFRGEDDQQVFSVRTFYDRPHELETKPALLETIDDWNRRTLWPKVYSHTHDDGTVRLIGEAQMLIGTGVSLEHFVSSTVSWVRAAIEFDRWLVEQLGLEQAVDSAADDEKPSDDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JNG0</accession>
    <name>A0A2M9JNG0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_28920</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000014">
        <property type="protein sequence ID" value="PJN08403.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08403">
        <property type="protein sequence ID" value="PJN08403"/>
        <property type="gene ID" value="CG723_28920"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014624602" evidence="2">
        <location>
            <begin position="33"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="29"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="29"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="49"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="66"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="87"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN08403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="131" mass="14382" checksum="3792E21B7677CBBC" modified="2018-04-25" version="1">MLAMKRKRVILSSVFIAASIGLAPVGWTQASAATPSETHVSTSASVKVPKSDRDYRRGFKDGFKSGLRQGQNNCRHGNGHNSNRQDNGKNGHVDGKRASAVHHKNAQQDYRRGFKDGFKSGVHQGQRSCRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JNN4</accession>
    <name>A0A2M9JNN4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Acyl-CoA dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CG723_29325</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CB01635</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000014">
        <property type="protein sequence ID" value="PJN08473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08473">
        <property type="protein sequence ID" value="PJN08473"/>
        <property type="gene ID" value="CG723_29325"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016627">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="SSF47203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="SSF56645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA_dh_N" evidence="5">
        <location>
            <begin position="7"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_1" evidence="4">
        <location>
            <begin position="238"/>
            <end position="366"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PJN08473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="379" mass="40379" checksum="694D5704AD4F2867" modified="2018-04-25" version="1">MDFTFTEEQQAAVEAAKAVFGPVAPDSVPSPALTPGAVADDFDRALWSKLADADLLSLLLAPEHGGAGLDAIALCLVLRESAKALARVPLLEHTAAAVAVQTYGSDELKEQILPRAARGELVLTAASAGRTGHDPAQLAVSARRDTDTDTWILDGAQTSVTWAHNADHIAVPAHTPQGRSVIAVLPHPHEGLTVAEQISTTGERLGELHLDSVRLEPHRIIETDEAWDRLHQLLTTGTCALALGLGERVLQMTGDYTSKREQFGYPVATFQAVAVQAADRYIDLRAMEATLWQAAWRISTQAGGALPTAGDIAVAKIWASEGVRRVVQTAQHLHGGFGADTDYPLHRYHAWAKQLELSLGPAAAHEETLGDLLAAHPLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JNT6</accession>
    <name>A0A2M9JNT6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">AMP-dependent synthetase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_27425</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000013">
        <property type="protein sequence ID" value="PJN08515.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08515">
        <property type="protein sequence ID" value="PJN08515"/>
        <property type="gene ID" value="CG723_27425"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-binding" evidence="1">
        <location>
            <begin position="15"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding_C" evidence="2">
        <location>
            <begin position="408"/>
            <end position="482"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN08515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="516" mass="53238" checksum="29F9982BADBD0478" modified="2018-04-25" version="1">MTERTFSYLTDQLRSHAALHPGRTALVIDGCPDLLYGEWDRRSEALARGLLAAGTSRGTRIGIFFGGMDWADYAVAYLGALKAGATVLHLPLALPADELERRALQCELAGIVHGRTVPPKTSAVAWTGTLDELSAPGETPVDLVHSPADAAEIVYSSGTTGLARGVVVSHQNLATAGGPPSVMAHDEPTPMVASVNLGITASATTVSMVLNATPTTLVLAPPGDADRLCALIEHHAASTVMMTPNLAVQMTRDGALGRYDLTSVTTVATASAFLHPPLARALLAAMPRARVIGAYSASQAKPAVTIGTFDPARPMSAGRPAPGTHVLITDEHGAELPAQRVGRIWLRADGAPPRNRLDAGPEATGVPDGGWCDTGDLGHVDDEGELYLFDRETDAVPTPAGLVSSLRVESVLLEHEAVADAAVVAAGPAGVAAAIVPAAGATHDPKLLAATLAAHAKDSLAPHEIPERVLVVDELPRNDLGKVVKRLIRDRLTASAAGVTPAPTASAELDATGAPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JNY3</accession>
    <name>A0A2M9JNY3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Thioesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_27845</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000013">
        <property type="protein sequence ID" value="PJN08581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08581">
        <property type="protein sequence ID" value="PJN08581"/>
        <property type="gene ID" value="CG723_27845"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003736">
        <property type="entry name" value="PAAI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006683">
        <property type="entry name" value="Thioestr_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03061">
        <property type="entry name" value="4HBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="SSF54637"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00369">
        <property type="entry name" value="unchar_dom_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4HBT" evidence="1">
        <location>
            <begin position="60"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN08581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="151" mass="16044" checksum="75303011E45FF3E6" modified="2018-04-25" version="1">MTTTDPAALTGLELMRWVQSTNSDDIPSIRRLIGMRVDDVDHGRVVMSLKTRPDFTNPLGTVHGGIAATLLDSVMGCAVHTTLPAGVGYTTLELKVNYIRASHVNGQKLTASGTVIHAGRRTATAEGKVLDDNGKLIAHATTTCLILQPAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JP42</accession>
    <name>A0A2M9JP42_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Diguanylate cyclase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_26420</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000012">
        <property type="protein sequence ID" value="PJN08638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08638">
        <property type="protein sequence ID" value="PJN08638"/>
        <property type="gene ID" value="CG723_26420"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013656">
        <property type="entry name" value="PAS_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013767">
        <property type="entry name" value="PAS_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00989">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08448">
        <property type="entry name" value="PAS_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PAS" evidence="2">
        <location>
            <begin position="22"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN08638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="465" mass="49487" checksum="0CC7821C3CACA231" modified="2018-04-25" version="1">MSASRRSGATDELGPDEPERDGADLLAALLDGMDAALCAFDADGIVTHWNREAERILGWSAAEAVGRRGFSGWAVRSADADEVEARLMAAMRAPGRQVHEFALLTKDGGRVLVRTQSSAVRGPDGKPAGLYCAFSEVHTQIDLERSIALSEALFEDAAWGVVLVDADLRPAVVNVHAARALGSGRTALLGRPLGDLISQGVEELESALAHVLAEGAPPAPAELWVTVRLPEGDARRCWRSGFVRLASPLTEEPVPLGVGWLFQDVTEAKQTEQEAAQLRFRANQLHRASRAAAECEDPAEAATIHLDFALAGFADHALIDLVVGDEQADGGADGERTGPVRLARAAATPSGAPGPSLLVPRTTLPVRYLEGHPALQCVERTGSVRAGASGRDATRAREWAEARQWPEGTVHALCAVLRSRARTLGVVTFLRGPSRTQFERADATYAESVAARIAGTLDLARVLDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JPA6</accession>
    <name>A0A2M9JPA6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Phosphoesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_26740</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000012">
        <property type="protein sequence ID" value="PJN08696.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08696">
        <property type="protein sequence ID" value="PJN08696"/>
        <property type="gene ID" value="CG723_26740"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003141">
        <property type="entry name" value="Pol/His_phosphatase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016195">
        <property type="entry name" value="Pol/histidinol_Pase-like"/>
    </dbReference>
    <dbReference type="SMART" id="SM00481">
        <property type="entry name" value="POLIIIAc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89550">
        <property type="entry name" value="SSF89550"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014974287" evidence="1">
        <location>
            <begin position="36"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="domain" description="POLIIIAc" evidence="2">
        <location>
            <begin position="195"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN08696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="509" mass="54376" checksum="700C2C097A84D6A5" modified="2018-04-25" version="1">MCEDDHTTTGMGRRALFVTGAATALTLSSVSFASAADGRTPADGTTTTRTVKGTLPPGAPDFVYVPVEVPRGVREIHVAYTYTKATVPAGTQNNALDIGVFDERGTALGGEGFRGWSGGARTEFFVRADDATPGYIPGPVRAGTWHIALGPYTVAPEGLPYELTVTLTYGEQGETPRPVYPPTRAKGRGRAWYRGDCHLHTWYSDGRRTPAEIAALAREAGLDFINSSDHNTHSSHAHWADQAGDDLLIMVGEEITTRNGHVVALGTEPGTFVDWRYRARDNRFGKYAREVRRAGGLVVPAHPHATCIGCNWKFGFGEADAVEVWNGAYTADDEISLADWDNTLVASVRGSRQWIPAMGNSDAHRDPDRIGGPQTVVLADDLTREAIQAGIKAGRSYVAESKSVELTFTASGSRGEHAGIGERLHVDPDAPVTVRLEVKGAPGCTLHLVTDQGTLFTAPALPESGSGTAEWRTTASYAAYVRAEVRHPATVPGLPGALTAFTNPVFLGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JPI8</accession>
    <name>A0A2M9JPI8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CG723_27340</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000012">
        <property type="protein sequence ID" value="PJN08792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08792">
        <property type="protein sequence ID" value="PJN08792"/>
        <property type="gene ID" value="CG723_27340"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PJN08792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="148" mass="16563" checksum="A2F0091AD6018378" modified="2018-04-25" version="1">MTQTTGKYTDFEGLRERAVALRREGLSLRQIADELGVRSEAAEAVGPLSDRELFLTGVALYWAEGAKSKPYRRSEVLQFINSDPEVVGVDASVFSKPTIKKHNPRTVRKNTGENYHGCLVIYVRQSAELYRRMEGAWYGIVLGARPTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JPJ6</accession>
    <name>A0A2M9JPJ6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Amidohydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_26705</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000012">
        <property type="protein sequence ID" value="PJN08803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08803">
        <property type="protein sequence ID" value="PJN08803"/>
        <property type="gene ID" value="CG723_26705"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016831">
        <property type="term" value="F:carboxy-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032465">
        <property type="entry name" value="ACMSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21240">
        <property type="entry name" value="PTHR21240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04909">
        <property type="entry name" value="Amidohydro_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydro-rel" evidence="2">
        <location>
            <begin position="120"/>
            <end position="410"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN08803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="422" mass="47172" checksum="0976301AB6FD5F21" modified="2018-04-25" version="1">METTETKKETGESPRVFPRIISVDDHTVEPPGVWQDRLPAKYRDEGPRIVRAPLKEMTFLGGKFAPVMGAPGEEGPIGDWWVYEDLHRPLTRLDTAVGYDRDEIKLEVITYEQMRKGSYDVPARLADMDVNHVQSALCFPTFPRFCGQTFTEAKNRELGLLGVRAYNDWMVEEWCGPQAQGRLIPLTLVPLWDAELAAAEVRRNAARGVRAVAFSEIPPHLGLPSVHTDEWDPFLRACDETGTVIAMHIGSSSKMPSTSADAPPAVGSTITFANCCFSMVDWLMSGKFERFPNLRIMYAEGQIGWIPYILERADVVWEENRGWGGVADKVRKRPSEYFADHVYGCFFDDAFGLRNLDAIGVANVLYETDYPHSDSTWPKSKEVGEAQMGHLDTDVVERIVRGNAIDLLGLTDDGLWAGQGGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-06-02" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JPM1</accession>
    <name>A0A2M9JPM1_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Ribosomal RNA small subunit methyltransferase I</fullName>
            <ecNumber evidence="7">2.1.1.198</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">16S rRNA 2'-O-ribose C1402 methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">rRNA (cytidine-2'-O-)-methyltransferase RsmI</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7 10" type="primary">rsmI</name>
        <name evidence="10" type="ORF">CG723_27185</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CB01635</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>cytidine(1402) in 16S rRNA + S-adenosyl-L-methionine = 2'-O-methylcytidine(1402) in 16S rRNA + H(+) + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:42924"/>
            <dbReference type="Rhea" id="RHEA-COMP:10285"/>
            <dbReference type="Rhea" id="RHEA-COMP:10286"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74495"/>
            <dbReference type="ChEBI" id="CHEBI:82748"/>
            <dbReference type="EC" id="2.1.1.198"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the methyltransferase superfamily. RsmI family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the precorrin methyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.198" evidence="7"/>
    <dbReference type="EMBL" id="NNBL01000012">
        <property type="protein sequence ID" value="PJN08819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08819">
        <property type="protein sequence ID" value="PJN08819"/>
        <property type="gene ID" value="CG723_27185"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070677">
        <property type="term" value="F:rRNA (cytosine-2'-O-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000453">
        <property type="term" value="P:enzyme-directed rRNA 2'-O-methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd11648">
        <property type="entry name" value="RsmI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.950.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1010.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01877">
        <property type="entry name" value="16SrRNA_methyltr_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000878">
        <property type="entry name" value="4pyrrol_Mease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035996">
        <property type="entry name" value="4pyrrol_Methylase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014777">
        <property type="entry name" value="4pyrrole_Mease_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014776">
        <property type="entry name" value="4pyrrole_Mease_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008189">
        <property type="entry name" value="rRNA_ssu_MeTfrase_I"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46111">
        <property type="entry name" value="PTHR46111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00590">
        <property type="entry name" value="TP_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005917">
        <property type="entry name" value="MTase_YraL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53790">
        <property type="entry name" value="SSF53790"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00096">
        <property type="entry name" value="TIGR00096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 7 10" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="6 7" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5 7 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="TP_methylase" evidence="9">
        <location>
            <begin position="10"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01877"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PJN08819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="298" mass="31380" checksum="6B5AF400214115E8" modified="2018-04-25" version="1">MTSSPESPGTLVLAGTPIGDVSDAPPRLSKELAGADVIAAEDTRRLRRLTQALGVTPGGRVVSYFEGNESARTPELVEALAGGARVLLVTDAGMPSVSDPGYRLVAAAVERDIKVTAVPGPSAVLTALALSGLPVDRFCFEGFLPRKAGERMGRLKEVAEERRTLVYFEAPHRLDDTLAAMAEAFGADRRAAVCRELTKTYEEVKRGPLGELAKWAAEGVRGEITVVVEGAPEKGAESLDASELVRRVQVREEAGERRKEAIAAVAAEAGLPKREVFDAVVAAKNAARGAPSEGKGLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JPN2</accession>
    <name>A0A2M9JPN2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Sugar ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CG723_25360</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CB01635</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000011">
        <property type="protein sequence ID" value="PJN08832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08832">
        <property type="protein sequence ID" value="PJN08832"/>
        <property type="gene ID" value="CG723_25360"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="68"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="103"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="139"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="193"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="236"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="68"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PJN08832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="276" mass="29734" checksum="F1F6CA4FDB18A3F5" modified="2018-04-25" version="1">MSSPRTVRHRLAADAGLLVVAAAFVLPLAWVVLSALDPHANLQVKIPDGVTLDNFDAVLTPDITFTPLLNSLLLCGGATLLTVASAALAAYPLSRYRSRFNNPFLATVLFATCLPITAIMVPVYALFVQVNLIDTMQGTIFFFAASQLPFAIWLMKNFMDGVPKELEEAAWTDGASSFQSLIRIVLPLMGPGVAVVTVFSFVMMWGNFFVPFMLLLTPEQMPASVSINDFFGNRGTVVYGQLAAFSIIYSTPVILLYVLVARRFGGGFALGGAVKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JPP7</accession>
    <name>A0A2M9JPP7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Co-chaperone YbbN</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CG723_25430</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000011">
        <property type="protein sequence ID" value="PJN08844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08844">
        <property type="protein sequence ID" value="PJN08844"/>
        <property type="gene ID" value="CG723_25430"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017937">
        <property type="entry name" value="Thioredoxin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00194">
        <property type="entry name" value="THIOREDOXIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="3">
        <location>
            <begin position="21"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PJN08844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="322" mass="33806" checksum="937945EBE071A2B2" modified="2018-04-25" version="1">MQPRNMSMSGVVDLAAVKAAQEAKAKAEQARAESARQGGGGAVSPSSLVIDVDEAGFERDVLQRSAEVPVVIDFWAEWCEPCKQLSPLLEGLAAEYNGRFVLAKIDVDANQMLMQQFGVQGIPAVFAVVAGQALPLFQGAAPVEQIRGTLDQLIQVAEERFGLIGITVDADAEGSAPVVEAPAGPYDALLEAAVQALDAGDLAGAVQAYKNVLSDDPGNTEAKLGLGQAELLLRVQDLDPQKVRQDAADRPSDVAAQIAAADLDLVGGHVADAFSRLVDTVKVTAGEDRDAARVRLLELFEVVGSDDPRVTTGRAALARVLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JPT4</accession>
    <name>A0A2M9JPT4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CG723_25715</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CB01635</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LytR/CpsA/Psr (LCP) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000011">
        <property type="protein sequence ID" value="PJN08893.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08893">
        <property type="protein sequence ID" value="PJN08893"/>
        <property type="gene ID" value="CG723_25715"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004474">
        <property type="entry name" value="LytR_CpsA_psr"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03816">
        <property type="entry name" value="LytR_cpsA_psr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00350">
        <property type="entry name" value="lytR_cpsA_psr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="35"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="domain" description="LytR_cpsA_psr" evidence="4">
        <location>
            <begin position="112"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="357"/>
            <end position="376"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF03816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PJN08893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="376" mass="38849" checksum="1B04DB005ACB43B7" modified="2018-04-25" version="1">MSDESSPATTDPSRPTRGGGGGGRRRKPRAKRSKALVITACTAAGLVVVAGAGAGFLYFKLNGNIKGVDINAALGTDRPTNVDNGSMDILVLGSDSRSGANAKYGEDGGGARSDTAMVVHVYKGHKKASVVSIPRDTLVTRPTCTDSAGNTVAGGSQQMFNTAYEVGGPACAVKTVEKMSGIRMDHYVEVDFSGFKKLINTLGGVDITTQQAINDDKSHLHLAAGTHTLTGEQALGLVRTRHAVGDGSDLGRIQLQQAFMKALINQIKDVGVFTSPKKLYDLADTATSAVTTDSELNSVKELAGFAGGLKGIGAGDMKMVTLPVQYDPADPNRVLPLEKAGARVWAAVKADQPVPASAIKNSAGDKGSAGSVVTSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JQ75</accession>
    <name>A0A2M9JQ75_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_24165</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000010">
        <property type="protein sequence ID" value="PJN09033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN09033">
        <property type="protein sequence ID" value="PJN09033"/>
        <property type="gene ID" value="CG723_24165"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="29"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="60"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="109"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="147"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="177"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="231"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN09033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="257" mass="26861" checksum="D2BDE44053576196" modified="2018-04-25" version="1">MTTAVPYRVTAPRVLRSEWHKFWTLRSTWITFAVASALVLAVGVTMGSTYDGDDSEIDTVVFVLLGTQLSQICVAVLGILVTASEYSTGMIRASLTAVPRRLPVLWSKAGVFAAVAFALSFVTNVVTFLVAQIWLSDGDKATSLTDAGVLGALAGNAAGITLMSLIALGLGGLLRSVPAAIGAFVGGVMILPEILGMLPYDAVDRAVNYFPTQSAESLGSATRLTDAVSPAMGLLSLTLWAAAVLTAAALLLRRRDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JQJ7</accession>
    <name>A0A2M9JQJ7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GNAT family N-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_24830</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000010">
        <property type="protein sequence ID" value="PJN09141.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN09141">
        <property type="protein sequence ID" value="PJN09141"/>
        <property type="gene ID" value="CG723_24830"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="7"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN09141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="187" mass="21193" checksum="5796252B8D3AC2C3" modified="2018-04-25" version="1">MKSMPTEYLRPAAAEDVPALMVLRTEAEQWLHEKGTDQWNDREAGARAISKWHATIDDGRAWIVVDDSGAALATVSRGPIDRDFWNDDDKPESAFYLYKLIVARSAAGRQLGVRIVDWASRVAALEGRDWVRIDTWRTNTGLHAYYERLGFKHVRTEAPSHRRSGWLAQRPADTISLPEQPLAVGKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JQL0</accession>
    <name>A0A2M9JQL0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ABC transporter substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_24935</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000010">
        <property type="protein sequence ID" value="PJN09158.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN09158">
        <property type="protein sequence ID" value="PJN09158"/>
        <property type="gene ID" value="CG723_24935"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006059">
        <property type="entry name" value="SBP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13416">
        <property type="entry name" value="SBP_bac_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014883508" evidence="2">
        <location>
            <begin position="19"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="389"/>
            <end position="416"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN09158.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="416" mass="44539" checksum="49171AD0B3462A7E" modified="2018-04-25" version="1">MTGLTAAVAALGMAATLAACGGPGSEDVTLKLVAADYGDSPANSSQKYWDKLAAAFEKKNPGIKVDVSVYSWSDVDAKVKKMVADGHAPDMAQIGAYSDYAASGKLYSANDLLSIPVQSDFLPQLADAGEVSRVQYGMPFASSTRLLFYNKTLFDKAGLTPPQTWAQLQADAKALKARGVKIPYALPLGPEEAQAETMMWMLSGGSGYTDDVGTYSLDSPQNVKTFEWLKNDLVGQGLTGPTPPAKLDRAQAFAAFTRGDVGMLNGHPTLMQMAAKKGVRFGTVPMPGINGRARSTMGVADWMMAFRQNGHKDQVGKFLDYVYSEKNVLDFSREYDLLPVTNSASDTMADDKRDQKLWKFLGELQNSELYPVGKTSWAQVSAGVKREIGSTVGPNGNPGATLGRLERAADAAENAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JQQ3</accession>
    <name>A0A2M9JQQ3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF2530 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_25190</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000010">
        <property type="protein sequence ID" value="PJN09206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN09206">
        <property type="protein sequence ID" value="PJN09206"/>
        <property type="gene ID" value="CG723_25190"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019681">
        <property type="entry name" value="DUF2530"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10745">
        <property type="entry name" value="DUF2530"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="49"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN09206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="88" mass="9705" checksum="77770894794C7B3A" modified="2018-04-25" version="1">MEKWTPKHEAPEPLEGPVVATITGGTILWFVLFLAQLPFYGWFDDHGHTWWIWTCLAGAGLGLIGIWYVRGRDAALKRAAAEAGPAAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JQR7</accession>
    <name>A0A2M9JQR7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Magnesium-transporting ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CG723_25185</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CB01635</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000010">
        <property type="protein sequence ID" value="PJN09205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN09205">
        <property type="protein sequence ID" value="PJN09205"/>
        <property type="gene ID" value="CG723_25185"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00120">
        <property type="entry name" value="HATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="SSF81653"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="SSF81665"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-1278">Translocase</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="58"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="83"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="232"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="271"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="612"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="643"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="683"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="714"/>
            <end position="732"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="739"/>
            <end position="758"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="770"/>
            <end position="790"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PJN09205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="799" mass="85176" checksum="5F5B86AD722D1FC2" modified="2018-04-25" version="1">MTHIDAGAELDPVHPVPVPERARGLTTAEVAERVARGEVNDIPVRSSRSTTEIIRANVFTRFNAIIGALWLIMLFVAPFQDSLFGYVILANTGIGIIQELRAKKTLDSLAVIGEAKPTVRRDGQATEISTSEIVLGDLIEIGPGDKIVVDGVCAEADSLEIDESLLTGEADPVVKKHRDPVMSGSFVVAGGGAFTATKVGREAYAAQLAEEASRFTLVQSELRTGISTILKYVTWMMVPTAIGLVISQLVVKENDFKDSVARTVGGIVPMVPEGLVLLTSVAFAIGVIRLGRKQCLVQELPAIEGLARVDTVCLDKTGTLTEGGMDITELRPLGEAEESYVRKVLGALGESDPRPNASLQAIIDAYPDSEEWRCTESLPFSSARKYSGAAFSEGDGTASAWLLGAPDVLLPAGHPVLAETEELNHQGLRVLLLARAAGDLDDPAVKEGAKAVALVAMEQRLRPDAADTLRYFADQGVHAKVISGDNAVSVGAVAGKLGLAGAQDTVDARTLPADQAGMAKALDENTVFGRVTPQQKRDMVGALQSKGHTVAMTGDGVNDVLALKDADIGVSMGSGSEATRAVAQIVLLNNSFSTLPSVVAEGRRVIGNITRVASLFLVKTVYSVLLAVLVVCFQIEYPFLPRHLTLLSTLTIGIPAFFLALAPNKERARPQFVKRVMRYAIPGGVVAGTATFVTYVIARHYYTGSGALDAETSSATLTLFLVSMWVLAIIARPYTWWRVCLVAAMGAAFLLVLVVPWLQDFFALKLVGASMPWTAVGIAAVAAVALEFVWRWVDRRFPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JRE8</accession>
    <name>A0A2M9JRE8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Polyphosphate glucokinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CG723_23565</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000009">
        <property type="protein sequence ID" value="PJN09424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN09424">
        <property type="protein sequence ID" value="PJN09424"/>
        <property type="gene ID" value="CG723_23565"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000600">
        <property type="entry name" value="ROK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18964">
        <property type="entry name" value="PTHR18964"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00480">
        <property type="entry name" value="ROK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PJN09424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="253" mass="26667" checksum="4A488DBEFD88A858" modified="2018-04-25" version="1">MQDKAAHVLGVDIGGTGIKGAAVDLELGSLMGERVRIPTPHPATPGAVADVVVTVLSQIGVPGPVGLTLPAVIRGGRVQTTSNIDPAWMETDAAQLFARVTSRDVRVVNDADAAGIAELRFGAGKGRKGVVVMVTLGTGIGSAVFTDGFLVPNSELGHLPLHHGDAEDWAAESVREHDDLSWKKWAHRLERYLELVQRLLWPDLIIIGGGVSKKADKFLPHIELRTEIVPAQLFNDAGIVGAALFAPAGEGQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JRL4</accession>
    <name>A0A2M9JRL4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CG723_22295</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000008">
        <property type="protein sequence ID" value="PJN09494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN09494">
        <property type="protein sequence ID" value="PJN09494"/>
        <property type="gene ID" value="CG723_22295"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PJN09494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="102" mass="11489" checksum="FEDCB9C414C54157" modified="2018-04-25" version="1">MNHVAVRLERTTDRDIHDDLVLSLGTWQHVSDSFYFANDPTTTATKNVPQQLAGLLEQWVELVRELTPTGGTVFLPFDFSDECTGWLRVKSQDGRIARVEAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JRV2</accession>
    <name>A0A2M9JRV2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">RNA polymerase subunit sigma-70</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CG723_23035</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CB01635</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2">Interacts transiently with the RNA polymerase catalytic core formed by RpoA, RpoB, RpoC and RpoZ (2 alpha, 1 beta, 1 beta' and 1 omega subunit) to form the RNA polymerase holoenzyme that can initiate transcription.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000008">
        <property type="protein sequence ID" value="PJN09606.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN09606">
        <property type="protein sequence ID" value="PJN09606"/>
        <property type="gene ID" value="CG723_23035"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050896">
        <property type="term" value="P:response to stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014303">
        <property type="entry name" value="RNA_pol_sigma-70_ECF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013249">
        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08281">
        <property type="entry name" value="Sigma70_r4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="SSF54427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02957">
        <property type="entry name" value="SigX4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="6">
        <location>
            <begin position="10"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4_2" evidence="7">
        <location>
            <begin position="110"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF08281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PJN09606.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="314" mass="34070" checksum="4DB1F410183A43F7" modified="2018-04-25" version="1">MSLRTYEADLFESSRGRLEAIAYRLLGSAGDAEDAVQDTYLRWHAADRELIETPEAWLTKVLTNLCLNQLTSARVRRETYVGQWLPEPVLAGDPMLGPADTAEQRESVSLAMLTLMERLSPNERAVYVLREAFGYPHRDIAEILDLTEANCQQIHRRAKQHLTAERARTEVDADAARKAVEEFLAAALSGDTEPLIRLLTADAVSVADGGAKVQARRTPVIGALGIARYLRGLFRPGAAKRAAVGGSAAVHSAVVNGGPALLITAGERVVGVMCLHTTPDGVGALHIQVNPDKLERFTGRWAAAGAHLPLTEIW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JSN6</accession>
    <name>A0A2M9JSN6_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF4439 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_21625</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000007">
        <property type="protein sequence ID" value="PJN09797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN09797">
        <property type="protein sequence ID" value="PJN09797"/>
        <property type="gene ID" value="CG723_21625"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029447">
        <property type="entry name" value="DUF4439"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012347">
        <property type="entry name" value="Ferritin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009078">
        <property type="entry name" value="Ferritin-like_SF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14530">
        <property type="entry name" value="DUF4439"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47240">
        <property type="entry name" value="SSF47240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4439" evidence="2">
        <location>
            <begin position="15"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="40"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="40"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN09797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="158" mass="16521" checksum="1B056BC05AF606F1" modified="2018-04-25" version="1">MADKGDKGDKQLLSAVQAALAAEHAAVYGYGVVGGRISESRRPEARTAYDSHRARRDDLRRTVRDLGGEPEPSAGAYALPFPVPDSAAAARLAADIEDRVAGVYSDLVRASEGARRRGAADALREAAVRAVRWRGGSVAFPGLAERAAAPQASATPQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JSQ4</accession>
    <name>A0A2M9JSQ4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">N-acetylneuraminate synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_19355</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000006">
        <property type="protein sequence ID" value="PJN09900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN09900">
        <property type="protein sequence ID" value="PJN09900"/>
        <property type="gene ID" value="CG723_19355"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016051">
        <property type="term" value="P:carbohydrate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013132">
        <property type="entry name" value="Neu5Ac_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03102">
        <property type="entry name" value="NeuB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NeuB" evidence="1">
        <location>
            <begin position="41"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN09900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="312" mass="34339" checksum="7F92A94295271DFB" modified="2018-04-25" version="1">MSTNSRLRTFGSKTAGPGQPVYITGEIGINHNGDLDNAFKLIDVAAEAGCDAVKFQKRTPEICTPRDQWDIERDTPWGRMTYIDYRHRVEFGEDEYRQIDEHCKKRGIDWFASPWDTEAVAFLEKFDIPAHKVASASLTDDELLRALRATGRTVILSTGMSTPKQIRHAVEVLGSDNILMCHATSTYPAQAEELNLRVINTLQAEYPNVPIGYSGHETGLQTTLAAVALGATFVERHITLDRAMWGSDQAASVEPQGLTRLVRDIRTIEASLGDGVKKVYESELGPMKKLRRVAGVVAESEIAVAAGEPVGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JT97</accession>
    <name>A0A2M9JT97_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_20455</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000006">
        <property type="protein sequence ID" value="PJN10083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN10083">
        <property type="protein sequence ID" value="PJN10083"/>
        <property type="gene ID" value="CG723_20455"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029046">
        <property type="entry name" value="LolA/LolB/LppX"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89392">
        <property type="entry name" value="SSF89392"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="210"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="215"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN10083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="233" mass="24566" checksum="3698F47953150E84" modified="2018-04-25" version="1">MRYGTVCLAVAGLVSCGSHEAPKGDESVTGALRAARSEVAAAGSARIEATSSTGTSLSSRSVGVLRWSGGLRGTLRVTATGGSMASTTRLMGGSPSQSRFLPDAYYTRMTDKFAALSDGKHWIRYPYAPGADLSPAASLKLLLSSGNAREVGRETVRGVRATHYTGTADGQRVDVWIDRGHLLIKRVQRARTDSGAFSGTVHYADYGARASAERPPARDTVDFKDVVGRKPTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JTA6</accession>
    <name>A0A2M9JTA6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DUF3291 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CG723_20515</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000006">
        <property type="protein sequence ID" value="PJN10093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN10093">
        <property type="protein sequence ID" value="PJN10093"/>
        <property type="gene ID" value="CG723_20515"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PJN10093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="126" mass="13920" checksum="38E32FD6549A7D9A" modified="2018-04-25" version="1">MPTLPWTVPNTPPAGAEAHVMASRFETRTLWGALRFFAKTPSVWRQVSKAPGAYGASVKAAPLRRTFWTLSAWESPDALKRFAGSAPHGPAAGGLRSQMKDAKFVRWQTTTDELPLDWAEALRRLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-09-29" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JTK7</accession>
    <name>A0A2M9JTK7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">4Fe-4S ferredoxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CG723_17715</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000005">
        <property type="protein sequence ID" value="PJN10231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN10231">
        <property type="protein sequence ID" value="PJN10231"/>
        <property type="gene ID" value="CG723_17715"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00037">
        <property type="entry name" value="Fer4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13247">
        <property type="entry name" value="Fer4_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="4">
        <location>
            <begin position="4"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="4">
        <location>
            <begin position="79"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PJN10231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="200" mass="21169" checksum="90CA56884F409ED8" modified="2018-04-25" version="1">MMGRTIFIDPGRCIGCQACVSACRECDSHRGKSMIHLDYPDEGHSVASLPTVCMHCEDPVAPCAEVCPADAILVTADGVVQQADTTRCIGCANCVNACPFGVPKIDLQAKLQMKCNLCYDRTAYGLAPMCATVCPTGALFYGTLEDLQAERPGVQVADSFTFGDVVVNTGVAMVVPADKVQWPVPGGLPIVQVNGKDVTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-05-25" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JU35</accession>
    <name>A0A2M9JU35_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Enoyl-CoA hydratase 2</fullName>
            <ecNumber evidence="1">4.2.1.119</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Enoyl-CoA hydratase 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CG723_18345</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CB01635</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>a (3R)-3-hydroxyacyl-CoA = a (2E)-enoyl-CoA + H2O</text>
            <dbReference type="Rhea" id="RHEA:26526"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:57319"/>
            <dbReference type="ChEBI" id="CHEBI:58856"/>
            <dbReference type="EC" id="4.2.1.119"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.119" evidence="1"/>
    <dbReference type="EMBL" id="NNBL01000005">
        <property type="protein sequence ID" value="PJN10338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN10338">
        <property type="protein sequence ID" value="PJN10338"/>
        <property type="gene ID" value="CG723_18345"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002539">
        <property type="entry name" value="MaoC-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01575">
        <property type="entry name" value="MaoC_dehydratas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="SSF54637"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="2" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MaoC-like" evidence="5">
        <location>
            <begin position="31"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00029334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00030115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PJN10338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="162" mass="18043" checksum="8616C16E8F244F6A" modified="2018-04-25" version="1">MTTTAIGRDFNTPVGERYFEDYVPGSSYVYGSVTVTEEEILRFAGEFDPQDIHTDPEAAEQGPFKGLIASGWHTASLMMRMYADHYVSKVASLASPGVDALRWTRPVRPGDSLSIRTTVVSARPSQSKPDRGIVHTDIEVFNQRGETVLTLSAMNFLRRRTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JU68</accession>
    <name>A0A2M9JU68_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Zinc-ribbon domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_18935</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000005">
        <property type="protein sequence ID" value="PJN10435.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN10435">
        <property type="protein sequence ID" value="PJN10435"/>
        <property type="gene ID" value="CG723_18935"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031493">
        <property type="entry name" value="Zinc_ribbon_15"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17032">
        <property type="entry name" value="zinc_ribbon_15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="zinc_ribbon_15" evidence="2">
        <location>
            <begin position="19"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="77"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="86"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF17032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN10435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="102" mass="11213" checksum="5E04E9F8068544A0" modified="2018-04-25" version="1">MIIFGTRGYLYQLAMLTFVCGNCGNPAAHALRKYVTKFTLFFVPLFPISTKYRSQCTFCGIEHHLAKEQAEALLAQAAAPAGHPAQGQQQPGQPLGQNPYQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JUJ1</accession>
    <name>A0A2M9JUJ1_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Beta-N-acetylhexosaminidase</fullName>
            <ecNumber evidence="3">3.2.1.52</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CG723_15105</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CB01635</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal non-reducing N-acetyl-D-hexosamine residues in N-acetyl-beta-D-hexosaminides.</text>
            <dbReference type="EC" id="3.2.1.52"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 20 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.52" evidence="3"/>
    <dbReference type="EMBL" id="NNBL01000004">
        <property type="protein sequence ID" value="PJN10550.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN10550">
        <property type="protein sequence ID" value="PJN10550"/>
        <property type="gene ID" value="CG723_15105"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004563">
        <property type="term" value="F:beta-N-acetylhexosaminidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102148">
        <property type="term" value="F:N-acetyl-beta-D-galactosaminidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.379.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025705">
        <property type="entry name" value="Beta_hexosaminidase_sua/sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015883">
        <property type="entry name" value="Glyco_hydro_20_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029018">
        <property type="entry name" value="Hex-like_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015882">
        <property type="entry name" value="HEX_bac_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22600">
        <property type="entry name" value="PTHR22600"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00728">
        <property type="entry name" value="Glyco_hydro_20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02838">
        <property type="entry name" value="Glyco_hydro_20b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001093">
        <property type="entry name" value="B-hxosamndse_ab_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00738">
        <property type="entry name" value="GLHYDRLASE20"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55545">
        <property type="entry name" value="SSF55545"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glyco_hydro_20b" evidence="7">
        <location>
            <begin position="7"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_hydro_20" evidence="6">
        <location>
            <begin position="143"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="530"/>
            <end position="550"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PJN10550.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="550" mass="61140" checksum="9579830A18F0A74B" modified="2018-04-25" version="1">MSVTSADLIPVPRRTAPGDGLHELGDATTIDAGAGTEGVARWLRSAVGAATGLALNDADTGTELRDGGTRIELRVDPELGPEAYRMTVDRHAVRVEGGSAAGVFWGAQTFRQLLGPDAYRRAPVEAVRTWTVPTGTVEDAPRFAWRGLMLDVSRHFMPKDGVLRYLDLLAAHKLNVFHFHLTDDQGWRVEIKRHPRLTEHGAWRARTKFGHRASPLWDDRPHGGFYTQDDIREIVAYAAQRHIRVVPEIDVPGHSQAAIAAYPELGNTDVVDTASLTVWDNWGVTPNVLAPTDHTLRFYEGVFEELLGLFPADVSPFIHIGGDECPKDQWKQSPAAQARIAELGLKDEDELQSWFIRHFDTWLTERGRRLIGWDEILEGGLAPGAAVSSWRGYQGGITAARAGHDVVMCPEQQVYLDHRQAPGDDEPMPIGYVRTLEDVYRFEPVPPQLTEDEARHVLGTQANVWTEVMESQDRVDYQVFPRLAAFAEVAWSALPAPAERDYADFRRRMTAHYARLDALGVGYRPPTGPLPWQQRPGVLGRPIEGAPPNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JUK3</accession>
    <name>A0A2M9JUK3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">MBL fold metallo-hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_18680</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000005">
        <property type="protein sequence ID" value="PJN10508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN10508">
        <property type="protein sequence ID" value="PJN10508"/>
        <property type="gene ID" value="CG723_18680"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lactamase_B" evidence="2">
        <location>
            <begin position="20"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="231"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN10508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="255" mass="27575" checksum="DADAE3063202B0A7" modified="2018-04-25" version="1">MREDTLVHAANSVHLVHGSNTNWVILSEGDAVTLIDCGYPGDRQQVLDSLDAAGHSPEAVTAILLTHAHNDHLGSADYLSRTFDAPVYAHEAEVPHARREFLHQVSLGRILRNGWRPGVLPWAVHALRSGGTTDARVDRAQPFPTEGALDLPGRPVPVHTPGHTAGHCAYHLPGAGIVISGDGLVTGHPTSRMRGPQLLPSMFDRDRDRTRDSLDVFENLAGDMLLPGHGRVHHGSVGEAARTARERATPARRRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JUP1</accession>
    <name>A0A2M9JUP1_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ATP-dependent Clp protease adapter protein ClpS</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">clpS</name>
        <name evidence="3" type="ORF">CG723_15330</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Binds to the N-terminal domain of the chaperone ClpA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ClpS family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000004">
        <property type="protein sequence ID" value="PJN10589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN10589">
        <property type="protein sequence ID" value="PJN10589"/>
        <property type="gene ID" value="CG723_15330"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030163">
        <property type="term" value="P:protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00302">
        <property type="entry name" value="ClpS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022935">
        <property type="entry name" value="ClpS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003769">
        <property type="entry name" value="ClpS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014719">
        <property type="entry name" value="Ribosomal_L7/12_C/ClpS-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33473">
        <property type="entry name" value="PTHR33473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02617">
        <property type="entry name" value="ClpS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54736">
        <property type="entry name" value="SSF54736"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ClpS" evidence="2">
        <location>
            <begin position="29"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN10589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="105" mass="11895" checksum="94AE46234F735065" modified="2018-04-25" version="1">MGCVTAPAPLEIERTESAEETFAVPEPDVPWITLVHNDPVNLMSYVTYVFQTYFGYSKDKATKLMLDVHQKGRAVVSSGSREEMERDVQAMHGYGLWATLQQDRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JV59</accession>
    <name>A0A2M9JV59_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">RNA polymerase subunit sigma-24</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CG723_16475</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CB01635</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000004">
        <property type="protein sequence ID" value="PJN10775.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN10775">
        <property type="protein sequence ID" value="PJN10775"/>
        <property type="gene ID" value="CG723_16475"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050896">
        <property type="term" value="P:response to stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039425">
        <property type="entry name" value="RNA_pol_sigma-70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013249">
        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43133">
        <property type="entry name" value="PTHR43133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08281">
        <property type="entry name" value="Sigma70_r4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="5">
        <location>
            <begin position="52"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4_2" evidence="6">
        <location>
            <begin position="116"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PJN10775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="173" mass="18862" checksum="E95C32D4A46E3C21" modified="2018-04-25" version="1">MPYVSDDDDRAATVRLVRAAQRGDTLAMATLLDELAPYVGRICGPIALDQGADAAQEALVAVFRSLRSLKDPAAVRGWVRTIAVREAVRMARRSARAVPADLSTLPARGDHQLAANIRDVLDRLSPEHRAVLVLRDVEGLDERAAAELLGVRVGTVKSRLSRARDTFRKAWTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JVD4</accession>
    <name>A0A2M9JVD4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Peptidase M48</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CG723_16915</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CB01635</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="6">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the peptidase M48 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000004">
        <property type="protein sequence ID" value="PJN10851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN10851">
        <property type="protein sequence ID" value="PJN10851"/>
        <property type="gene ID" value="CG723_16915"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001915">
        <property type="entry name" value="Peptidase_M48"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01435">
        <property type="entry name" value="Peptidase_M48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 6" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="1 6" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase_M48" evidence="8">
        <location>
            <begin position="102"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="341"/>
            <end position="362"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PJN10851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="362" mass="40014" checksum="7036FAEECA9FF0DD" modified="2018-04-25" version="1">MSDVNDGNDGQREHVPSRQRRRFEGISSRAYEHPADRSALVALRKLTGFDTVFKALSGLLPERSLRLLFLSDSVRVSDDQFAHLNDMLRDACYILDLEKVPPMYVNQDPQPNAMCIGLDEPIIVVTTGLVELLDEEEMRAVVGHEVGHALSGHSVYRTILLFLTSLALRVAWIPLGNLAIMTIVTALREWFRKSELSADRAGLLVGQDLNASMRGLMKIAGGNHLHEMNVDAFLKQAEEYEAGGDLRDSVLKILNVLPRTHPFTTVRAAELKKWAATRDYQRIMDGHYPRRTEDKDTSVTDSFRQSASHYADNMRNSKDPLMKLVTDIAGGAGDLGGKLRGKFGGGNGGAHTGNHGTPEDGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-06-02" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JVI3</accession>
    <name>A0A2M9JVI3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Zinc ABC transporter substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CG723_17280</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CB01635</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the bacterial solute-binding protein 9 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000004">
        <property type="protein sequence ID" value="PJN10911.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN10911">
        <property type="protein sequence ID" value="PJN10911"/>
        <property type="gene ID" value="CG723_17280"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007155">
        <property type="term" value="P:cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030001">
        <property type="term" value="P:metal ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006129">
        <property type="entry name" value="AdhesinB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006128">
        <property type="entry name" value="Lipoprotein_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006127">
        <property type="entry name" value="ZnuA-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01297">
        <property type="entry name" value="ZnuA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00691">
        <property type="entry name" value="ADHESINB"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00690">
        <property type="entry name" value="ADHESNFAMILY"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0732">Signal</keyword>
    <keyword evidence="1 3" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014689691" evidence="5">
        <location>
            <begin position="29"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="129"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="129"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PJN10911.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="318" mass="33604" checksum="B181CE7862975848" modified="2018-04-25" version="1">MNVRRLIPTAAVASVTVLGLTALSACSASSGDGRNSDGKLAVVASFYPMQYLAEQIGGDHVAVTNLTKPGQEPHDLEISAKQTAQLQDAGVALYLKGLQPAVDDAIQQSGIKTKVDAASLTHLEKHGTEVGGHAEEHDHEHGSEGGSDPHIWLDPVRYAEVAEGVGKAFEKADPDHAAAYRKNTAALVGKLDGLNTRFKDGLKDTGSKVFITTHAAFGYLAERYGLTEEAISGLDPESEPSAARVKDLQSMAKADGVTTIFYETLVSDRTAKTLAGDAHLKTDVLDPLEGITDKSKGDDYIQVMDSNLKALQTALGAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JVI7</accession>
    <name>A0A2M9JVI7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">GntR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CG723_17245</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000004">
        <property type="protein sequence ID" value="PJN10905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN10905">
        <property type="protein sequence ID" value="PJN10905"/>
        <property type="gene ID" value="CG723_17245"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07377">
        <property type="entry name" value="WHTH_GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.530">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011711">
        <property type="entry name" value="GntR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008920">
        <property type="entry name" value="TF_FadR/GntR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07729">
        <property type="entry name" value="FCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
        <property type="entry name" value="GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00035">
        <property type="entry name" value="HTHGNTR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00895">
        <property type="entry name" value="FCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00345">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48008">
        <property type="entry name" value="SSF48008"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50949">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH gntR-type" evidence="4">
        <location>
            <begin position="16"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PJN10905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="247" mass="27485" checksum="CF1C7A852F01CE09" modified="2018-04-25" version="1">MRRMSEEPRNPAIRHRRVSQQVQRAVTQLILDRGLRPGELLPTEAELMESLGVSRNSVRESLKALQALDIVEIRHGYGTYVGQASLTPLADGLTFRTLLRPAADAHALAEILQVREILEEGLIRRVAAAPLPPEILDRLDDIVRKMAAAGQVDEPFADLDRDFHETLYGSLGNELIPQLLGAFWNVFDRVAGARSWSSDPDPDVTVSRHRDIVTALRAQDAVGAQRAMAHHFRGIEARAEQETRGVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JVU8</accession>
    <name>A0A2M9JVU8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">2-nitropropane dioxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_17070</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000004">
        <property type="protein sequence ID" value="PJN10877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN10877">
        <property type="protein sequence ID" value="PJN10877"/>
        <property type="gene ID" value="CG723_17070"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018580">
        <property type="term" value="F:nitronate monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04730">
        <property type="entry name" value="NPD_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004136">
        <property type="entry name" value="NMO"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03060">
        <property type="entry name" value="NMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NMO" evidence="1">
        <location>
            <begin position="4"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN10877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="357" mass="36857" checksum="494CF7A328F7075A" modified="2018-04-25" version="1">MSPTLTDLCHYPIVQAPMAGGASCPQLAAAVSEAGGLGFLAAGYKTADGMYQEIKQVRGLTNQPFGVNLFMPQSEYADPAAVAVYASQLAGEAAWYDTQLGDPDCGLDDGFDAKLAILLDDPVPVVTFTFGCPSRDVLNSLARVGTLTAVTVTTADEAQAAQRAGADAVCVQGIEAGGHQGTHRDNPEADGSGIGLIALITQVREAVQIPIIATGGLMRGGQLAAVLAAGADAGQFGTAFLVCPESGANVLHKQAMTNPLFVRTELTRAFSGRPARGLVNRFMREHGPYAPAAYPQIHHMTSTLRKAAAKAGDPQGMALWAGQGHRLARELPAGRLVEALAAELAEAKDALGARGAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-09-29" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JVX2</accession>
    <name>A0A2M9JVX2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Peptidoglycan bridge formation protein FemAB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_08730</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FemABX family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN11055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN11055">
        <property type="protein sequence ID" value="PJN11055"/>
        <property type="gene ID" value="CG723_08730"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016755">
        <property type="term" value="F:aminoacyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044038">
        <property type="term" value="P:cell wall macromolecule biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003447">
        <property type="entry name" value="FEMABX"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02388">
        <property type="entry name" value="FemAB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51191">
        <property type="entry name" value="FEMABX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN11055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="373" mass="42887" checksum="808BFAAE156C58E9" modified="2018-04-25" version="1">MSYRLKAITREEHLAFVTTRPSVSHMQVPSWGDVKPDWRAESLGWFDDDDRLVGVGLVLLRPLPKLKRYLAYLPEGPAIDWAATDLKLWLEPMLAHLKERGVFSVKMGPPVVARRWSAEVVKAAIADPQARQLRDVEATAHEPRAFDLADRLRRMGWQQTEPGGEDGFAAGQPRYVFQVSFAGRTLEEVQRDFNQQWRRNIKKADKAGVKVVQGGYEDLPTFYALYVETAKRDRFIPRPLAYFQRMWTVLRAEDEDRMRLYLAHHEGEVLAAATMLTVGEHVWYSYGASTSRRREVQPNNAIQWRMMCDAYELGASIYDFRGITDTLDEANHLLGLLRFKAGTGGQAVEYLGEWDYPLNKVLHKALDLYMSRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JWA4</accession>
    <name>A0A2M9JWA4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_09495</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN11173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN11173">
        <property type="protein sequence ID" value="PJN11173"/>
        <property type="gene ID" value="CG723_09495"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="24"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="68"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="94"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="119"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN11173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="144" mass="15199" checksum="01EC76207C12A208" modified="2018-04-25" version="1">MASNVSGTGSGTARSSPSTGIGSGWLVFAAVLMVFGGLMMLFQGIAAIAKDDVFVVTRHYVYQFDLTAWGWIHLILGVIIALVGVALLFTGATWARVVGVVLTGLAMLANFLWAPYAPLWAIVLIAINAFVIWALCAAPSPSER</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JWM2</accession>
    <name>A0A2M9JWM2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Arylsulfatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_10085</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN11274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN11274">
        <property type="protein sequence ID" value="PJN11274"/>
        <property type="gene ID" value="CG723_10085"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036361">
        <property type="term" value="F:racemase activity, acting on amino acids and derivatives"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006807">
        <property type="term" value="P:nitrogen compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015942">
        <property type="entry name" value="Asp/Glu/hydantoin_racemase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01177">
        <property type="entry name" value="Asp_Glu_race"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="188"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN11274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="216" mass="21904" checksum="13E904552A30CC56" modified="2018-04-25" version="1">MNLALLHTSPVHVPVFDALRDTDHPGLALRHLVDESLLERARAAGPDAVADDVRALLETAVADGASAVLCTCSTIGGVAEAQSAAAGVPVLRVDRPMAAAAVEAGRAVAVVAALESTLDPTVALVEEEAARAGRPVDVRTVLVAGAWERFEAGDRDGYRDLVAAAVDALTDVDVVVLAQASMASAADRTTTTVPVLSSPRPGLGAAAGNTAYAEPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JWY4</accession>
    <name>A0A2M9JWY4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CG723_10340</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN11322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN11322">
        <property type="protein sequence ID" value="PJN11322"/>
        <property type="gene ID" value="CG723_10340"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PJN11322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="84" mass="9038" checksum="EAED99B7F9425A90" modified="2018-04-25" version="1">MTAWHAPIVVHPPAPEGGRHVTVRGRAVGLAHSDQDLIRLLRSAGLGESDMTLDDPHLVEWRGAGAHVWHTTGPDEPSPHHPVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JX60</accession>
    <name>A0A2M9JX60_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Asparagine synthase (Glutamine-hydrolyzing)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">asnB</name>
        <name evidence="8" type="ORF">CG723_11260</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CB01635</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the asparagine synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN11474.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN11474">
        <property type="protein sequence ID" value="PJN11474"/>
        <property type="gene ID" value="CG723_11260"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004066">
        <property type="term" value="F:asparagine synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006529">
        <property type="term" value="P:asparagine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01991">
        <property type="entry name" value="Asn_Synthase_B_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00712">
        <property type="entry name" value="AsnB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006426">
        <property type="entry name" value="Asn_synth_AEB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001962">
        <property type="entry name" value="Asn_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033738">
        <property type="entry name" value="AsnB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017932">
        <property type="entry name" value="GATase_2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00733">
        <property type="entry name" value="Asn_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13537">
        <property type="entry name" value="GATase_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001589">
        <property type="entry name" value="Asn_synthetase_glu-h"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="SSF56235"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01536">
        <property type="entry name" value="asn_synth_AEB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51278">
        <property type="entry name" value="GATASE_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0061">Asparagine biosynthesis</keyword>
    <keyword evidence="3 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 5" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutamine amidotransferase type-2" evidence="7">
        <location>
            <begin position="2"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="active site" description="For GATase activity" evidence="5">
        <location>
            <position position="2"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="99"/>
        </location>
        <ligand>
            <name>L-glutamine</name>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="289"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="368"/>
            <end position="369"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR001589-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR001589-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PJN11474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="644" mass="71239" checksum="A63BD8E761497098" modified="2018-04-25" version="1">MCGIAGTYRWPDGKVVTDRLTDTLAHRGPDGAGRYSHPAGDGEVHLGHRRLAIVDLSETGAQPMVSGGLVLTYNGELYNAPELRAELAAAGVRFRGTSDTEVLLEAWRRWGTDCLPRLRGMFAFGIFDERTGELVLARDQLGIKPLFLLRRGAGLVFASELKALAAVTDGSLQVDHAALVASLLYYWVPDSRCAFREAEKLPPGSWLRCRPDGRVERGRYWNLKDVAAEGRERARSGEQPDLAAIVEESTRQHLLSDVPVATFLSGGLDSSYLTALAARHQPGISAYTIGFRAEDAKFEAMPDDLRYARQVAERFGVDLHEIEIAPNVLDLLPQMTYHLDEPIGDPAAINTFLICSAAREAGVKVMLSGMGADELFAGYRKHLANLLALRYQRVPRPLRRGVFKAVDRLPVATARRGYRSVRFAKRFLSFADLPEETAFRRSYTMYDQDELLALVSPDLAGTVDDVLTEHADIYQDNELDDFVNRMCLGDARMFLPGLNLAYTDRSSMAASTEVRVPYVDVEVVKAAFAVPGDRKIVGRQGKAVLKEAATSILPREIVYRPKGLFSAPLRAWMSRDLAPLVREVVNDGVLVSSGLLRRDALARMVAEDASGQRDFSKHLWHVLTLEYWYRDATSGSARSTRSAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JXA5</accession>
    <name>A0A2M9JXA5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Acyl-CoA dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CG723_10715</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CB01635</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN11387.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN11387">
        <property type="protein sequence ID" value="PJN11387"/>
        <property type="gene ID" value="CG723_10715"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016627">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="SSF47203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="SSF56645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0274">FAD</keyword>
    <keyword evidence="3 5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA_dh_N" evidence="8">
        <location>
            <begin position="27"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_M" evidence="7">
        <location>
            <begin position="111"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_1" evidence="6">
        <location>
            <begin position="219"/>
            <end position="376"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PJN11387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="395" mass="43588" checksum="6E2C065E5EA41710" modified="2018-04-25" version="1">MTDAAELRSRTQELLAAYPPATTDRTDFLKARFDAGLAWVHYPQGLGGLGLPRSLQAVVDAELAAADAPDNDPRRIGIGLGMAAPTVLGFGTDEQKQRFLRPLWIGEEVWCQLFSEPGAGSDLAALGTRAVRDEATGDWVINGQKVWTSGAHTARWAILIARTDPDVPKHRGITYFICDMTDPGVEVRPLRQITGEAEFNEVFLTDVRIPDTHRLGEIGDGWKVAQTTLMNERVSIGGSRIPREGGMISAVAKTWRERPELRTHDLHQRLLKLWVEAEVARLTGERLRQQLVAGQPGPEGSGMKLGFARLNQEISGLEIELLGDEGLLYDDWTMRRPAVVDFLARDAGYRYLRAKGNSIEGGTSEVLLNIVAERVLGLPSEPRTDKDVAWKDLAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JXD8</accession>
    <name>A0A2M9JXD8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Asparagine synthase (Glutamine-hydrolyzing)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">asnB</name>
        <name evidence="9" type="ORF">CG723_11695</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CB01635</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the asparagine synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN11554.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN11554">
        <property type="protein sequence ID" value="PJN11554"/>
        <property type="gene ID" value="CG723_11695"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004066">
        <property type="term" value="F:asparagine synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006529">
        <property type="term" value="P:asparagine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01991">
        <property type="entry name" value="Asn_Synthase_B_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00712">
        <property type="entry name" value="AsnB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006426">
        <property type="entry name" value="Asn_synth_AEB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001962">
        <property type="entry name" value="Asn_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033738">
        <property type="entry name" value="AsnB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017932">
        <property type="entry name" value="GATase_2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00733">
        <property type="entry name" value="Asn_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13537">
        <property type="entry name" value="GATase_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001589">
        <property type="entry name" value="Asn_synthetase_glu-h"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="SSF56235"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01536">
        <property type="entry name" value="asn_synth_AEB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51278">
        <property type="entry name" value="GATASE_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0061">Asparagine biosynthesis</keyword>
    <keyword evidence="3 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 5" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutamine amidotransferase type-2" evidence="8">
        <location>
            <begin position="2"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="active site" description="For GATase activity" evidence="5">
        <location>
            <position position="2"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="102"/>
        </location>
        <ligand>
            <name>L-glutamine</name>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="261"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="291"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="377"/>
            <end position="378"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="site" description="Important for beta-aspartyl-AMP intermediate formation" evidence="7">
        <location>
            <position position="379"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR001589-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR001589-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR001589-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PJN11554.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="613" mass="68893" checksum="B6B13C3E081E9381" modified="2018-04-25" version="1">MCGITGWVSFDRDLRASADTLDAMTQTMECRGPDDRGTWTEGPAALGHRRLAIIDLPGGRQPMTAETPRGTVALVYSGETYNYTELRRELTGHGHTFTTESDTEVVLRGYLEWGEGLAQRLNGMYAFAVWDGRENKLVMIRDRMGIKPFYFYETPDGVLFGSEPKAILANPLARSRVTLDGLRELFTIVKTPGHAVWDGMHEVEPGTIVTVDRSGLRQRAYWTLETRPHTDDRETSIATVRSLLDDIVRRQLVSDVPRCTLLSGGLDSSAMTAIAARQLGEQGETVRSFAVDFVGQTENFVADEMRGTPDTPYVHDVAKAAGTDHRDIVLDSNELADPEVRARVIRARDIPAGFGDMDASLYLLFRAIREHSTVALSGESADEVFGGYLQFFDEEARSADTFPWLVRMSQHFGDDADVLRGDLAGALDLDGYVRNSYAGAVRGIQRLDGESDFEFRMRRMCHLHLTRFVRVLLDRKDRTSMAVGLEVRVPFCDHRLVEYVYNTPWSLKSFDGREKSLLREATADVLPKSVYDRAKSPYPSTQDPKYAVALQNQAKDLLARPSHRVFDLVDRERVTRAAHRDVPQTEQASRRGLERTLDLALWLDMYSPELVLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JXJ6</accession>
    <name>A0A2M9JXJ6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Osmotically inducible protein OsmC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CG723_11735</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN11562.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN11562">
        <property type="protein sequence ID" value="PJN11562"/>
        <property type="gene ID" value="CG723_11735"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015946">
        <property type="entry name" value="KH_dom-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003718">
        <property type="entry name" value="OsmC/Ohr_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036102">
        <property type="entry name" value="OsmC/Ohrsf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02566">
        <property type="entry name" value="OsmC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82784">
        <property type="entry name" value="SSF82784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PJN11562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="146" mass="15920" checksum="FF3DB012F97DC876" modified="2018-04-25" version="1">MADYRIETVRNGFRDWTARNDRGAEVRIGAAEDPDVQPSFTPVELLLAALGGCGGLVTDRTARTVEHDGLRIVVESVSRPEDDGRVGAVRVSYEVELPEGDEHAADAFARGVRLTHEKYCTVSRTVEHGARIEARLPDGTLVFMAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JXK5</accession>
    <name>A0A2M9JXK5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">HIT family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_12055</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN11614.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN11614">
        <property type="protein sequence ID" value="PJN11614"/>
        <property type="gene ID" value="CG723_12055"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.428.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001310">
        <property type="entry name" value="Histidine_triad_HIT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011146">
        <property type="entry name" value="HIT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036265">
        <property type="entry name" value="HIT-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46648">
        <property type="entry name" value="PTHR46648"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01230">
        <property type="entry name" value="HIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54197">
        <property type="entry name" value="SSF54197"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51084">
        <property type="entry name" value="HIT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HIT" evidence="2">
        <location>
            <begin position="41"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Histidine triad motif" evidence="1">
        <location>
            <begin position="99"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN11614.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="154" mass="17394" checksum="7A798E3C4F3DF91E" modified="2018-04-25" version="1">MTDHDCYPCGKEAQFAGLPPRERIAFDEHWRVVHAIRTALPGWLVLLPRRHVTAVHDLTDAQAATLGVWQVRLSRALRSVTGCEKTYVAQFAEAEGFSHVHFHVVPRLPDLPQERRGPGVFAMLGRPEGEWVTDGEADRIARELRAHLRPEPPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JXQ0</accession>
    <name>A0A2M9JXQ0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_12085</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN11618.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN11618">
        <property type="protein sequence ID" value="PJN11618"/>
        <property type="gene ID" value="CG723_12085"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011704">
        <property type="entry name" value="ATPase_dyneun-rel_AAA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07728">
        <property type="entry name" value="AAA_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA" evidence="1">
        <location>
            <begin position="37"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN11618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="289" mass="31514" checksum="5F627449DEC425FE" modified="2018-04-25" version="1">MTSGYFTSVDDVSARLAATGYLASPAVATTVFLADRLGKPLLVEGPAGVGKTELAKAVAEVAGATLVRLQCYEGVDESRALYEWNHAKQLLRITAGRDESWDETRTDIFSEEFLLPRPLLTAIRGSDPKVLLIDETDKADVEVEGLLLEVLSDFQVTVPELGTISATRRPFTVLTSNASRELSEALRRRCLFLHIGFPEEELERRIVRLKVPGLDEALAQAVVRVVGALRAMDLRKVPSVAETIDWARTLLALGAGTLDEQVVRDTLGVVLKHQEDVLKAAAKLDLDAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JXQ6</accession>
    <name>A0A2M9JXQ6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Alpha-mannosidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CG723_12400</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CB01635</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 38 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN11666.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN11666">
        <property type="protein sequence ID" value="PJN11666"/>
        <property type="gene ID" value="CG723_12400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004559">
        <property type="term" value="F:alpha-mannosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006013">
        <property type="term" value="P:mannose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041147">
        <property type="entry name" value="GH38_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011682">
        <property type="entry name" value="Glyco_hydro_38_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015341">
        <property type="entry name" value="Glyco_hydro_38_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037094">
        <property type="entry name" value="Glyco_hydro_38_cen_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000602">
        <property type="entry name" value="Glyco_hydro_38_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027291">
        <property type="entry name" value="Glyco_hydro_38_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028995">
        <property type="entry name" value="Glyco_hydro_57/38_cen_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09261">
        <property type="entry name" value="Alpha-mann_mid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17677">
        <property type="entry name" value="Glyco_hydro38C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07748">
        <property type="entry name" value="Glyco_hydro_38C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01074">
        <property type="entry name" value="Glyco_hydro_38N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00872">
        <property type="entry name" value="Alpha-mann_mid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="SSF74650"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88688">
        <property type="entry name" value="SSF88688"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="SSF88713"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha-mann_mid" evidence="5">
        <location>
            <begin position="519"/>
            <end position="597"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PJN11666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="1004" mass="110614" checksum="65FCA02F4AD53DDC" modified="2018-04-25" version="1">MHDDRTLVEARLKRVLDERIRPAVYPESVPLQVAVWNAPGEPVPVEEGLAATPEPIAVGARWGAPWATCWFRVTGTVPDDWAGRTVEAILDLGFDENMPGFQCEGLVYRPDGTPVKGLNPRNQWVRVGAPVEGGEEVRLHIEAASNPVILDYHPFLPTQLGDKETAGSEPQYTLARMDLAVLDETVWQLVMDLEVLGELMAELPVESARRYDILRAVERALDAVDLQDVNSTAAAARERLTGVLAAPAVPSAHRISAVGHAHIDSAWLWPLRETVRKVARTTSNMTALLEDEPDFVFAMSQAQQWAWVKEHRPEVWARVKKAVADGRFVPAGGMWVESDTNMPGSEAMARQFVHGKRFFLDEFGIENDEAWLPDTFGFAAGLPQIIKAAGSKWLLTQKISWSQTNKFPHHTFQWEGIDGTRIFTHFPPVDTYNCSMKGSEIAHAAKNFKDKGVARHSLAPTGWGDGGGGTTREMVAKAARLRDLEGSATVVWETPEEFFKKAEAEYPNPPVWVGELYLELHRATLTSQAMTKQGNRRSEHLLREAELWAATAAVRAGLPYPYEELDRIWKTVLLHQFHDILPGSSIAWVHREARRTYERVAEELNGIIGAAQRALAGEGSGTLVFNSAPHTRDGVPAGGARNPVIEGEAAIASRAAGGFVLDNGLLRVEIDGRGLVVSAYDLVAGRETVAPGRAANLLQIHPDFPNMWDAWDVDEFYRNTVTDLVDADEVAPGEGASVRIVRSFGDSRVTQVLSLTAGERRLGIDTEVDWHETEKFLKLAFPLDIHAERYASETQFGHCFRPTHTNTSWEAAKFEACNHRFVHIEEPGWGVSLVNDSTYGHDVTRTVRDSDSGTTTTVRVSLLRAPRFPDPETDQGVHRFRHALVPGAAIGDAVREGYRINLPERHVTGSGEVAPLVDVDQDAVVVTAVKLADDGSGDVVIRFHESRGGRVRATLTAGFEVAAAATTDLLERPLADAADPERVGDRITLSLRPFELVTLRLKRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JYH4</accession>
    <name>A0A2M9JYH4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_14035</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN11936.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN11936">
        <property type="protein sequence ID" value="PJN11936"/>
        <property type="gene ID" value="CG723_14035"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016624">
        <property type="entry name" value="UCP014753"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35339">
        <property type="entry name" value="PTHR35339"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10022">
        <property type="entry name" value="DUF2264"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF014753">
        <property type="entry name" value="UCP014753"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="405"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="405"/>
            <end position="420"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN11936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="624" mass="67136" checksum="F657B894B6F02DA1" modified="2018-04-25" version="1">MTIPFELPEEDRELSPRTGYTRAHWEAVADGLLGAAWRWATPEGALLDLPGRPSASGVRSDGLEGFARTFLTAGFRVAGAGGKDPHGWLERYAQGLTAGTRTPGRDDAESWPLILEHHVQGQPMVESASVALGLSLTRPWLWDRLDDDVQDRAETWLRGAINHTPAPNNWYLFPFTVASFLESVGRGDAATTRVMERALGLMETWYRGDGWYADGDGQAFDHYNGWALHLYPMLHAHLSGDTALAARFGPRLREHLEGFSLLFGADGAPIHFGRSLTYRFAASAAVGIGAVTGHTPLTPGTSRRLISGSLRYFLDRGGVTDDGLLSLGWHGPHDATLQTYSGPASPYWASKGFVALLAPEDDPLWTATEEPAPSEGPDRVLALPAPGLLVQSTQADGIVRLHNHGSDHVRPHESESAAQDDPLYGRHAYSTHTGPTSRTNVADNHLSVVVGGAASARRRIRPLGAGQGDGWGWAASSHLPVFASGPPMVPGLRAESVTVARGRYELRVHRVVGAPHGAGVTLTGWASDALSSQLHGLYGWGERDEVRAPQGTAYERWVRVPRLSGEAEGTAVFVALASLSADEPSAPLTDVVTDVRFSEGELRVLWADGPQTTVAFEPVRVTHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JYL6</accession>
    <name>A0A2M9JYL6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CG723_14250</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN11972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN11972">
        <property type="protein sequence ID" value="PJN11972"/>
        <property type="gene ID" value="CG723_14250"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PJN11972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="270" mass="28627" checksum="519180F02A59607A" modified="2018-04-25" version="1">MQINGKVAIVTGAAGGIGAAIAQRLLEHDAQGVLLTDLDAGRLDATVKQLAGSHGERVGGVAGNAASTADLERIVDAAEERFGPVDLYFANAGVGGGAGLDASEDEWSRALDVNVMAHVRAAKLLVPRWMERGAGYFFSTASAAGLLTQIGSATYSVSKHGAVAFAEWLSVTYGDSGVRVSCLCPQGVETELLMAGTRSDDPVERAAARAVLDSGELLRPLDVADRVMEAVGDERFLVLPHPQVLDFYRHKGSDYDRWLRGMRRYQASVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JYN2</accession>
    <name>A0A2M9JYN2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_13640</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN11867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN11867">
        <property type="protein sequence ID" value="PJN11867"/>
        <property type="gene ID" value="CG723_13640"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="40"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="70"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="109"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN11867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="136" mass="14392" checksum="B7042E4E62570ADC" modified="2018-04-25" version="1">MRVAVLCVWLVTASLGGYLATVWIRHGGLQQRTPGVTRLPLWLVLGHIALAVAGLAAWTAYLLGNARGSAWAACAVVLIVAAFGFMMLFRWLPSRGRHAQGHATAERNFPLTAVVAHGMSAAVTVLLVALVVLGRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JYQ6</accession>
    <name>A0A2M9JYQ6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_13740</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN11887.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN11887">
        <property type="protein sequence ID" value="PJN11887"/>
        <property type="gene ID" value="CG723_13740"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="32"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="73"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="122"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="171"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="207"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="253"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="296"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN11887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="450" mass="47073" checksum="71B52345DF6D0B22" modified="2018-04-25" version="1">MTATIAAGPAAAARVSVARGYRFELVKLVSQWRVRLLVLACWIAPALFVAAVSQQSSLPVDTLFGRWMHATGWAGSLVVLGFSGTWALPLLTSVVAGDVFASEDRLGTWRHLLVAVRSPRRIFAAKALASLTVILLLVAGLACSGAAGGIVAVGNQPLVGLDGHLLSPGDAAVQVLLAWVCVLAPTLAFAAIGLLGSVALGRSPMGLLLPMLVALTMQLAQMLPLPVAVRLALPSYAFIAWNGLFTGPAQLGPLLIGIVVSLLWAVTATALAYALFLRRDFTNLTHDGSGRRAITVGALPLVGLLVLTAVVVAPATSATGSGIEQDKVQRSVATAFAHLYRLQTEQLNRPDVTEAQLKASAVCTKGSTRVAAEGPGNDWRCVVSWHLPDVEATGSAIYQLDVTADGRFMADGDGPKEVNGYFLVRTPTGDGPNPLWQFDGNVELLPTSKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JZ19</accession>
    <name>A0A2M9JZ19_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">LysR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_10375</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LysR transcriptional regulatory family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN12133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN12133">
        <property type="protein sequence ID" value="PJN12133"/>
        <property type="gene ID" value="CG723_10375"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005119">
        <property type="entry name" value="LysR_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000847">
        <property type="entry name" value="Tscrpt_reg_HTH_LysR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00126">
        <property type="entry name" value="HTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03466">
        <property type="entry name" value="LysR_substrate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00039">
        <property type="entry name" value="HTHLYSR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50931">
        <property type="entry name" value="HTH_LYSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH lysR-type" evidence="2">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN12133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="293" mass="31907" checksum="DC0FD50A50C030F3" modified="2018-04-25" version="1">MQFQQLQYFVAVAETRHFTRAAEVVHVAQPSLSQQIRSLERELGADLFLRARGNITLTDAGEALLPLARRILADADTARQEVQELAQLKSGRVRLGATPSLCTGLLPDVLRSFHDRYPGIRLMIEEGGSHDLVRELARGALDLALVVLPLPAPAPALTTVELLREDLVVVSSPDAPRPGRGRSVRIADLEGERLVMFRHGYDLRELTVTACRAEGFEPDFAVEGGEMDAVLGFVRAGLGVAVVPHMVATRAGADLRVTPLARPGLHRTIALAHRSDVAPPRAARELQRMLLEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-06-02" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JZ23</accession>
    <name>A0A2M9JZ23_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CG723_14460</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN12007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN12007">
        <property type="protein sequence ID" value="PJN12007"/>
        <property type="gene ID" value="CG723_14460"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014889855" evidence="3">
        <location>
            <begin position="22"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="168"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="209"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="246"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="312"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="342"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="387"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="274"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="274"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PJN12007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="415" mass="42872" checksum="F9E51EA8AD7365EA" modified="2018-04-25" version="1">MLLLLAAVPVLLFGSAGTAQAHPFGTPPVVRIEANGPVVETAWSAQKDDIAVVKKHSGGDVARYLRSHIVVRQDGAPCRVAKADGMKIRFVCPHRVDRISLTVTALTDVNPAYRTLSVTDQGGGALHTAREPTRELSLVSGESGAGTGSSAAGGMWTTNLASLLDHGAGLPTALLVAAAVGALHACAPGHGKSLAAGYLVGGRGRPRDAVWLGGVVAVMHTFSVGVLAVGWWLLAKSAPDMAALTGWLQLIAALVVVGVGVRLLHTHLRRRRQVDVRTQTHHGHGHRHEGGHEHGHRHHIPDPPSLLTWRGLVLLGAAGGLLPSPSAFLVLLAGLLTGKVAVALALVAAFGVGMAVTLTGVGVLVLRSRDALLDRLSRSRALRTWTLRVPVFAASAVVVGGTVASALAAGQLLAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-09-29" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JZ86</accession>
    <name>A0A2M9JZ86_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">1,4-alpha-glucan branching enzyme GlgB</fullName>
            <ecNumber evidence="9">2.4.1.18</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">1,4-alpha-D-glucan:1,4-alpha-D-glucan 6-glucosyl-transferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Alpha-(1-&gt;4)-glucan branching enzyme</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Glycogen branching enzyme</fullName>
            <shortName evidence="9">BE</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9 12" type="primary">glgB</name>
        <name evidence="12" type="ORF">CG723_12365</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">CB01635</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>Transfers a segment of a (1-&gt;4)-alpha-D-glucan chain to a primary hydroxy group in a similar glucan chain.</text>
            <dbReference type="EC" id="2.4.1.18"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 9">Glycan biosynthesis; glycogen biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the glycosyl hydrolase 13 family. GlgB subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.18" evidence="9"/>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN12180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN12180">
        <property type="protein sequence ID" value="PJN12180"/>
        <property type="gene ID" value="CG723_12365"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00164"/>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003844">
        <property type="term" value="F:1,4-alpha-glucan branching enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102752">
        <property type="term" value="F:1,4-alpha-glucan branching enzyme activity (using a glucosylated glycogenin as primer for glycogen synthesis)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043169">
        <property type="term" value="F:cation binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005978">
        <property type="term" value="P:glycogen biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02855">
        <property type="entry name" value="E_set_GBE_prok_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00685">
        <property type="entry name" value="GlgB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006048">
        <property type="entry name" value="A-amylase/branching_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037439">
        <property type="entry name" value="Branching_enzy"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006407">
        <property type="entry name" value="GlgB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044143">
        <property type="entry name" value="GlgB_N_E_set_prok"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006047">
        <property type="entry name" value="Glyco_hydro_13_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004193">
        <property type="entry name" value="Glyco_hydro_13_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43651">
        <property type="entry name" value="PTHR43651"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00128">
        <property type="entry name" value="Alpha-amylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02806">
        <property type="entry name" value="Alpha-amylase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02922">
        <property type="entry name" value="CBM_48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000463">
        <property type="entry name" value="GlgB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00642">
        <property type="entry name" value="Aamy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="SSF81296"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01515">
        <property type="entry name" value="branching_enzym"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="7 9" id="KW-0320">Glycogen biosynthesis</keyword>
    <keyword evidence="4 9" id="KW-0321">Glycogen metabolism</keyword>
    <keyword evidence="5 9" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aamy" evidence="11">
        <location>
            <begin position="258"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="9 10">
        <location>
            <position position="410"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="9 10">
        <location>
            <position position="463"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000463-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PJN12180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="741" mass="82334" checksum="2292B590C8E9EB89" modified="2018-04-25" version="1">MSDKPGPGRLKVLPAPVLDGADRGRLLWGEHHDPHSLLGAHPVDGGVAFRVLRPYAQAVAVSIKGRRAELHDEGDGLFAGVLPLDAIPAYTLLVTYDGDEREVDDPYRFLPALGEFDLHLIGEGRHEELWTALGAQPMTHEGVAGTRFTVWAPNARGVRVCGDFCAWDGTAFPMRSLGSSGVWELFLPGIGEGALYKFDITRPDGSHTVRADPLARRTEVPPATASVVTESSHTWGDSAWMKKRGQRPVHEAPFSVYEVHLPSWRPGTNYRELADQLATYVSDLGFTHVEFMPVAEHPFGGSWGYQVTGFYAPTSRMGSPDDFRHLVDTLHQAGIGVIVDWVPAHFPKDDWALAGFDGTALYEPQDPRRAEHPDWGTLEFDYGRKEVRNFLVANAVYWCEEFHIDGLRVDAVASMLYLDYSREEGQWSPNEHGGRENLDAVAFLQEMNATVYRRCPGVVTIAEESTAWDGVTRPTHHVGPGGFGGLGFGLKWNMGWSHDSLQYIAHEPVHRKYHHNELTFSMVYAYSENYLLPLSHDEVVHGKRALVSKMSGDWWQRRADHRAYLGFMWAHPGKQLLFMGQEFAQGAEWSEGHGPDWWLLDPAYEAEPDHRGVLDLVRDLNHEYAAAPALWERDTTPEGFSWITADAADDNVLAFLRFAADGAPLLAVCNFSPAVRENYRLGVPDSVPGWFEVLNTDAARYGGGDVVNAGVLKPDPQPSHGRPVSLQLTVPPLATVWLRPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JZG2</accession>
    <name>A0A2M9JZG2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Coagulation factor 5/8 type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CG723_14735</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN12238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN12238">
        <property type="protein sequence ID" value="PJN12238"/>
        <property type="gene ID" value="CG723_14735"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00161">
        <property type="entry name" value="RICIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035992">
        <property type="entry name" value="Ricin_B-like_lectins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000772">
        <property type="entry name" value="Ricin_B_lectin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00652">
        <property type="entry name" value="Ricin_B_lectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00458">
        <property type="entry name" value="RICIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50370">
        <property type="entry name" value="SSF50370"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50231">
        <property type="entry name" value="RICIN_B_LECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014987168" evidence="2">
        <location>
            <begin position="27"/>
            <end position="722"/>
        </location>
    </feature>
    <feature type="domain" description="Ricin B-type lectin" evidence="3">
        <location>
            <begin position="30"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="703"/>
            <end position="722"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="704"/>
            <end position="722"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PJN12238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="722" mass="75868" checksum="E434F315ADFEAA3F" modified="2018-04-25" version="1">MASSMSGVAVAAQGNATAREPVTAQAAAPPTGWATVVNAGSGKCVDARAAGTTDGTAVQQYTCNSTQVQQWRIEATSGGYSRVDNRADAGKAWDVTDVSTADSAPVQLWTYSGGANQQWQAVAESSGAYHFVNRNSGKCLDVPSASTSDSVQLTQYTCNGTAAQSFYVNPVDVTPPPGTPDLGPNVTVFDPSTPAATIQSSLNAAFAQQETNQFGTARKAFLFKPGTYDANANVGFYTQVAGLGLSPDDVTIRGAVHAEADWFQGNATQNFWRSAENLSVTPTGGTDRWAVSQAAPYRRMHLRGNLALDDGGWSSGGYMADTKIDGQVNSGSQQQWLSRNTEWGSWTGSNWNMVFVGAKNAPANSFPSPPYTTVAQAPVTREKPFLYVDAAGSWKVFVPSARANTSGTTWSSGTPAGASLPLDDFFIVKPGATAAQMNDALAAGKNLLVTPGVYHLGQTLKVTRPDTVVLGLGLATLIPDNGITAMTVADVDGVQLAGLLIDAGTTNSAQLMEMGPSGSSVDHSADPSALHDVFFRIGGAGVGKATTSLTINSDDVIGDHLWLWRADHGSGVGWTSNTADTGLVVNGDDATMYGLFVEHYQKHQTIWNGNGGRTYFYQNEMPYDPPNQAAWMNGSTQGYAAYKVANSVTSHQVYGFGSYCYFNVNPGVAAEHAIEAPNNANVRFKDMVTVSLGGTGTIRHVVNDRGGPSNSSTNVANLVSYP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JZS5</accession>
    <name>A0A2M9JZS5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">ABC transporter substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CG723_04870</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000002">
        <property type="protein sequence ID" value="PJN12385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN12385">
        <property type="protein sequence ID" value="PJN12385"/>
        <property type="gene ID" value="CG723_04870"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005693">
        <property type="entry name" value="Mce"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003399">
        <property type="entry name" value="Mce/MlaD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024516">
        <property type="entry name" value="Mce_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11887">
        <property type="entry name" value="Mce4_CUP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02470">
        <property type="entry name" value="MlaD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01782">
        <property type="entry name" value="MCEVIRFACTOR"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00996">
        <property type="entry name" value="Mtu_fam_mce"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MlaD" evidence="2">
        <location>
            <begin position="45"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="domain" description="Mce4_CUP1" evidence="3">
        <location>
            <begin position="125"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="324"/>
            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF11887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PJN12385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="346" mass="36786" checksum="C375A23BC60A0CA9" modified="2018-04-25" version="1">MRLPRPKPMKERNPVAVALAGLVVLAVVALLAFNADRLPLVGSGTAYTADFTEAAGLGEGDEVRIAGVKVGEVTGVSLDGGRVRVTFDAGDAWIGDRSTAAIAIKTLLGDKYLAVDPLGSARQDPGSRIPVSRTTSPYDVTQAFQDLSSTVDEIDTAQLAKSFETISDTFKDSPPDVRAAATGLSELSKSVSKRDTQLAELLKGSRQLTKTLKSKKSSFETLIDDGGSLLGELKDRRAAVKALLKGSKELGTELKGVVDDNDKQLGPTLKALGRVTTVLEKNNKNLDRTLALVGPYYRLIGNTLGNGRWFDSYLCGVVPPEYLPKEQRTTDCKPPQQGASAKGAGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-09-29" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K004</accession>
    <name>A0A2M9K004_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CG723_05200</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000002">
        <property type="protein sequence ID" value="PJN12438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN12438">
        <property type="protein sequence ID" value="PJN12438"/>
        <property type="gene ID" value="CG723_05200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PJN12438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="171" mass="18890" checksum="7EFF6D3785F902E9" modified="2018-04-25" version="1">MIVWLNGTFGAGKTTTSNELVKLLPDARIFDSENVGYLLRDVIGDVPCDNFQEWEPWRSLTVATARDVLGFVGGTLVIPQTVLVEDYWTQIIDGLAAAGIPVHHFVLHTDADTLTRRINGDTEEIRPWRLKHIASYNDALPWLSRAATVVDTTERAPSDVAAQIAERVGHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K037</accession>
    <name>A0A2M9K037_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">TetR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_05480</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000002">
        <property type="protein sequence ID" value="PJN12486.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN12486">
        <property type="protein sequence ID" value="PJN12486"/>
        <property type="gene ID" value="CG723_05480"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004111">
        <property type="entry name" value="Repressor_TetR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02909">
        <property type="entry name" value="TetR_C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="8"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="29"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN12486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="202" mass="21389" checksum="123C8338502B6EE6" modified="2018-04-25" version="1">MGRPSKPLLDRERITTTALELVDEQGDFSVPRIAKRLGVQTGSVYHHVDGRDGIVELLRERVAVAIDPATLTGGERPWAEALADWARSYRAAFAAHPKAIPLLTTSPVRAQRVLDQYELAAGLLLDAGFALPDVMPVIIGLENVVLGSALDMAAPEAMWELADETATPRLAAALAAMGAGRADAAFELALTGFLAHVSAMAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K061</accession>
    <name>A0A2M9K061_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_05680</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000002">
        <property type="protein sequence ID" value="PJN12523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN12523">
        <property type="protein sequence ID" value="PJN12523"/>
        <property type="gene ID" value="CG723_05680"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="171"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN12523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="496" mass="53940" checksum="E3FC70E3F150E254" modified="2018-04-25" version="1">MTERPPQRTPNRQLAALIAEAGFSNAGLARRVDQLGLEHGLDLRYDKTSVTRWLRGQQPRGTTPALIAEVFTRRLGRRLSAQDLGLDACSPVYAGLEFAASPEEAVDIVSGLWRKDSGSHAELRKIAFTPAGLVVPSRDWLIGRADDRVAHGDHGGPGGVRIPAQGRAPAKLTAGLEPGPPPLPRQRGHAERGPGQRVTAGDIAALRSVGELFRSLDQAYGGGHARQALVRYLEHEAEPMLRGTYGEQTGRRLFAATADLTRLAGWTSYDIAAHGLAQRYFVQALRLSQAAGDRMYGSYVLVTMSRQAVYLGHGREAVQLARVAQQGAGSSAPPAVQALLHAAEARGHGVLGEVRACTASLVRAERTLEAVRTGDDVPHWARFFDEAQLADEFGHCHRDLQQYRAAAQHAERSLQLRAPGFARSRLFCRVVLASARLGLGELDQACTLGAEAAQAASEMRSVRAHEYVREFERRLEPYRDAAPVRGYRDRIAALSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K143</accession>
    <name>A0A2M9K143_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CG723_07440</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000002">
        <property type="protein sequence ID" value="PJN12836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN12836">
        <property type="protein sequence ID" value="PJN12836"/>
        <property type="gene ID" value="CG723_07440"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PJN12836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="247" mass="27423" checksum="33223439DB38C917" modified="2018-04-25" version="1">MTNEPREFEIAREFEVDATPEQVWEALTSGTGGWLWPMEYEPKAGGRGPHGATITAWDPEHRLTARSDNPDALPPFQTLNQLDHVIEARDGGSRAWVRYVHSGIFTDNWDDYYDGADKHTDFYLHTLRQYLTHFAGRPVAFTMFDGPAASANTEALAAVGRALGLPDDAAEGTKLRVRGPGGETLEAVLDYRNPYFIGLRTDDALYRIFGRGRWGAPVGIVVHDFAPDADAAQDETAWRGWLDGVFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K1H7</accession>
    <name>A0A2M9K1H7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CG723_05190</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000002">
        <property type="protein sequence ID" value="PJN12981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN12981">
        <property type="protein sequence ID" value="PJN12981"/>
        <property type="gene ID" value="CG723_05190"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007344">
        <property type="entry name" value="GrpB/CoaE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34822">
        <property type="entry name" value="PTHR34822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04229">
        <property type="entry name" value="GrpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="SSF81301"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PJN12981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="195" mass="21305" checksum="0259CAF572CEA9B8" modified="2018-04-25" version="1">MPESEIPVVAPYDAAWPERGRALCAELGAALGPMALRAEHIGSTSIPGMAAKPVYDLQVSVADLDEAEASFAGPLADLGFRLSRYRRDHVPAGLDDVPSRWAKRFWSRRGTAADPVNLHVRLAGSPNERLALLFRDWFRTHPEAVPAYAHFKYALASRVSDTGTYADVKDPVVDLVVAVAEKWAAETGWTPEPED</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K1L3</accession>
    <name>A0A2M9K1L3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">3-alpha-hydroxysteroid dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CG723_06575</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000002">
        <property type="protein sequence ID" value="PJN13008.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN13008">
        <property type="protein sequence ID" value="PJN13008"/>
        <property type="gene ID" value="CG723_06575"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PJN13008.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="238" mass="24281" checksum="6C77417CB6EA5D3D" modified="2018-04-25" version="1">MDGKVVVITGAGRGQGAAEAALAAAAGARVVVTDVREEEGAEVAESLGGQGLFVRHDVSDPDSWGEVVDATLGAFGRIDALVNNAALWRTAPVERETLENFEQLIRVNLLGPFLGIQAVVPAMKEAGGGSVVNVSSTAGLIGIPGHAAYGSTKFGLRGLTRSSALDLAGYGIRVNSVHPGAIDTPMIAGVSGKDWSHLPLGRMGRPEEVGELVLFLASDASSYITGTEFTVDGGSTAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K2C7</accession>
    <name>A0A2M9K2C7_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">PDZ domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CG723_01445</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000001">
        <property type="protein sequence ID" value="PJN13278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN13278">
        <property type="protein sequence ID" value="PJN13278"/>
        <property type="gene ID" value="CG723_01445"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13180">
        <property type="entry name" value="PDZ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="SSF50156"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="41"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="3">
        <location>
            <begin position="112"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="79"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="88"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PJN13278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="197" mass="19751" checksum="D5674DA3318807F8" modified="2018-04-25" version="1">MEQTALRPKSMPGAPRREAAARGNGSGGRRPHAARRRGKRLVTLLLGLLFGAVLVLSGVGLGTVGAAVIGMSKLAEMQQQAGAAPRPPALTPSHPPTSSASPSPSARPVRAALGVEAVDAPKGAGALLVGVHVPGPGYTAGLVRGDVLIAFGETRIGSAGALAQAVESARPGRQVTLTVRHESGVRQVLAVTPGVVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-09-29" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K2F8</accession>
    <name>A0A2M9K2F8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative baseplate assembly protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_01345</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000001">
        <property type="protein sequence ID" value="PJN13260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN13260">
        <property type="protein sequence ID" value="PJN13260"/>
        <property type="gene ID" value="CG723_01345"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00118">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.350.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011749">
        <property type="entry name" value="CHP02243"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018392">
        <property type="entry name" value="LysM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036779">
        <property type="entry name" value="LysM_dom_sf"/>
    </dbReference>
    <dbReference type="SMART" id="SM00257">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02243">
        <property type="entry name" value="TIGR02243"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51782">
        <property type="entry name" value="LYSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LysM" evidence="2">
        <location>
            <begin position="1179"/>
            <end position="1226"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="269"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="274"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN13260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="1252" mass="134087" checksum="5336019F03B04F25" modified="2018-04-25" version="1">MSQACSCGGACGGHDERLAPAPLHNPPGRTALDYRVGEYGSFLAALLDRLASPAYPALGGLTVRTPDDPAIGLLDATAVLGDLLTFHSERIADEAYIRTAGEHRSLVLLGRLVGHRPRPGVAAATHLAYTLERDPRAEALPVLIPRGARTHGVPASADEESVTFETSRDLTARWDWNELKVRRRRPSLVTPEDLERRSELFVEGTANSLQTGDQLLFVFGEQAGGRRNLLPVAGVRIDRDDDITAISLQKSAPPTLKELVDEVRRWTAEPAAPGEPGEEPPTPEVPNPRPVSRLIEDFEDQVLAPLRAALDDVKTPESLAAALAEPVARLGEAQVLATGWEDVAAWFEQLEAVLAELAERALELAPTRTAGTPVATKAKSTADPRDAAFRTLAAVLPALRAQTPAPPSGTGPQRPGTDTARLLAALNPGLTGLYPAWRRAGAAAPGGAQLLRDLLAMRVTASPFGATAPLKPVQDDKGRVIRSADWPLTGAMLTSMRVVHDTAGKAPIRAEFQYVEGNGSDQRAVPLPVTRQVTFALGPGQVDLSTRSAQDRDLSWLVRRPADSQEPGVTVRLRDGLPECTLFVSRPDQDRLIHVGINNGTAQELSLRPGATEQFTHGEYEVSLRYTVGSTEPNVEVVIASKPAPVNRRVLQLDTVHTGITVGSWVAIQRPAKGAQDGIPGDAELAFVTTQVVAARTAAYTNYGITGRGTELTLVDPWLDEFDVLLSHIRDTTVYAAGEPLRPADEPLGEEVHGNGIELAELYDGLRAGRTLIVTGERSDIPGTAGVTAAEVVTIAATDQTVDPQLPGDRVHTHLTLTTDLAHRYRRETVRILGNVVEATHGESREEAIGSGDSDRVNQTFALWQSPLTWLADDNPLGATPVLEIRVDGVLWHEVDSLAGRGPRERIYITGTASDGRTTVTFGDGVHGARLPSGHENVHARYRFGTGKAANVPADRLTQPLTRPLGVTAVTNLRPATGGADADGPGLTRRTIPLAVSALDRLVSAADYEDFARSRAGIGRAAARELFDGRRRVLHVTVAGTDDVPLDGGSDTLRALRGALTEYGDANLPVRVDVRELVLLLVAAKVKVAPDHAWEFVEPRLRQALLRRLGYEGRELGQAARLSDVLAAAHTVPGVDYVDVDVFNGVPASATPEELTALLTDPGAPRSSVPAHEATYDEKIHTVRDADGETLSAVCARYGIPLAELLRLNPDITDTRRLAKGRSVVVFRGIRPAQLALLSPRAADTLILTEVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K2P2</accession>
    <name>A0A2M9K2P2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Glyoxylate carboligase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">gcl</name>
        <name evidence="6" type="ORF">CG723_02105</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CB01635</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the TPP enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000001">
        <property type="protein sequence ID" value="PJN13392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN13392">
        <property type="protein sequence ID" value="PJN13392"/>
        <property type="gene ID" value="CG723_02105"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009028">
        <property type="term" value="F:tartronate-semialdehyde synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030976">
        <property type="term" value="F:thiamine pyrophosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009436">
        <property type="term" value="P:glyoxylate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006397">
        <property type="entry name" value="Glyox_carbo_lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012000">
        <property type="entry name" value="Thiamin_PyroP_enz_cen_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012001">
        <property type="entry name" value="Thiamin_PyroP_enz_TPP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045229">
        <property type="entry name" value="TPP_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011766">
        <property type="entry name" value="TPP_enzyme-bd_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18968">
        <property type="entry name" value="PTHR18968"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18968:SF14">
        <property type="entry name" value="PTHR18968:SF14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02775">
        <property type="entry name" value="TPP_enzyme_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00205">
        <property type="entry name" value="TPP_enzyme_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02776">
        <property type="entry name" value="TPP_enzyme_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="SSF52467"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01504">
        <property type="entry name" value="glyox_carbo_lig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0436">Ligase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0786">Thiamine pyrophosphate</keyword>
    <feature type="domain" description="TPP_enzyme_N" evidence="5">
        <location>
            <begin position="4"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="domain" description="TPP_enzyme_M" evidence="3">
        <location>
            <begin position="193"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="domain" description="TPP_enzyme_C" evidence="4">
        <location>
            <begin position="394"/>
            <end position="553"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU362132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PJN13392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="595" mass="64439" checksum="0F94ABDB240A033B" modified="2018-04-25" version="1">MARMTAASAAVEILKREGVTNAFGVPGAAINPFYKSLKEVGGISHTLARHVEGASHMAEGYTRTNPGNIGVCIGTSGPAGTDMITGLYSATGDSIPILCITGQAPSHLLHKEDFQAVDIASIAKPVTKMAVTVLEAAQVPGVFQQAFHLMRSGRPGPVLIDLPIDVQQTEIDFDPETYEPLPVYKPAATRAQIEKAISFLLESERPLIVAGGGIINANASDLLVEFAEITNTPVVPTLMGWGTIPDDHDLNAGMVGQQTGHRYGNATFLESDFVLGIGNRWANRHTGYKLDVYREGRKFVHVDIEPTQIGKIFAPDYGIASDAKAALELFVEVARELKAAGKLPDRSAWVASHLERKGTLHRRTHFDNVPMKPQRVYEEMNKAFGPDTRYVTTIGLSQIAGAQMLHVYKPRHWINCGQAGPLGWTIPAALGVATADPETQVVALSGDYDFQFMIEELAVGAQHRIPYVHVLVNNAYLGLIRQAQIGLDINFQVNLEFENQNSPELGVYGVDHVKVAEGLGCKAIRVTEPDQLLPAFEEAKKLAAQYRVPVVVEAILERITNISMSPTADISAVKEFEELATEPGHAPTAIRPLTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K3C3</accession>
    <name>A0A2M9K3C3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MarR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_03470</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000001">
        <property type="protein sequence ID" value="PJN13625.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN13625">
        <property type="protein sequence ID" value="PJN13625"/>
        <property type="gene ID" value="CG723_03470"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000835">
        <property type="entry name" value="HTH_MarR-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12802">
        <property type="entry name" value="MarR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00598">
        <property type="entry name" value="HTHMARR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00347">
        <property type="entry name" value="HTH_MARR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50995">
        <property type="entry name" value="HTH_MARR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH marR-type" evidence="1">
        <location>
            <begin position="1"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN13625.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="153" mass="17089" checksum="FB6A03FE964047A2" modified="2018-04-25" version="1">MAAVDLTTHPGHLARRLQQAHYLLWNTMVSEEITSPQFAVLNALVAEPGLDQRTVGERVGLDRSTIAEVISRLSRRGLIDKVRDPQDGRRSLLRLTDDGTRVHRKLTVRTARMNQIFLAPLSADEQAVFFDLIQRVSDAAEGLRNPTEPLAKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K3L1</accession>
    <name>A0A2M9K3L1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Cell division protein FtsK</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CG723_00035</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CB01635</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Essential cell division protein that coordinates cell division and chromosome segregation. The N-terminus is involved in assembly of the cell-division machinery. The C-terminus functions as a DNA motor that moves dsDNA in an ATP-dependent manner towards the dif recombination site, which is located within the replication terminus region. Required for activation of the Xer recombinase, allowing activation of chromosome unlinking by recombination.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the FtsK/SpoIIIE/SftA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000001">
        <property type="protein sequence ID" value="PJN13713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN13713">
        <property type="protein sequence ID" value="PJN13713"/>
        <property type="gene ID" value="CG723_00035"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041027">
        <property type="entry name" value="FtsK_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002543">
        <property type="entry name" value="FtsK_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018541">
        <property type="entry name" value="Ftsk_gamma"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17854">
        <property type="entry name" value="FtsK_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09397">
        <property type="entry name" value="FtsK_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01580">
        <property type="entry name" value="FtsK_SpoIIIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00843">
        <property type="entry name" value="Ftsk_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50901">
        <property type="entry name" value="FTSK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="9" id="KW-0132">Cell division</keyword>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014870542" evidence="7">
        <location>
            <begin position="18"/>
            <end position="923"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="100"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="130"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="167"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="221"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="domain" description="FtsK" evidence="8">
        <location>
            <begin position="570"/>
            <end position="770"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="263"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="364"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="27"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="263"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="587"/>
            <end position="594"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006474"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00024986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PJN13713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="923" mass="97905" checksum="C0252F9EDA36DCEA" modified="2018-04-25" version="1">MASRPAAKKSPAKRAAAPTKAPAKKAPAKKVAAKKPAAKKAPPRKAAAKKPAPKPAPSPTGGVYRLARALWLGVAHSVGAMFRGIGRGAKGLDPAHRKDGLALLLLGLALIVAAGTWSNLRGPVGDLVEMLVTGAFGRLDLLVPLLLGGIAVRLIRHPEKPEANGRIVIGLSALVIGVLGQVHIACGSPARTDGMQAIRDAGGLIGWGASTPLSFTMGEVLAVPLLVLLTVFGLLVVTATPVNAIPQRLRLLGVKLGVVHPDPEGDLRGADGAADDDERYDDQWRESLPARSRRRPADPEAYDPDQAEQEALSKRRRPRRTPVQPVVTRPMDAVDVAAAAAAALDGAVLHGMPPSPLVADLTQGVGTERKSAPERTAPVPTARAKTPVKETKEADPEPAAAAAKAGVPDLTKSAPDAPRDLPPRAEQLQLSGDITYSLPSLDLLERGGPGKSRSAANDAVVDSLSNVFSEFKVDATVTGFTRGPTVTRYEIELGPAVKVEKITALAKNIAYAVASPDVRIISPIPGKSAVGIEIPNTDREMVNVGDVLRLADAAEDDHPMLVALGKDVEGGYVMANMAKMPHILVAGATGSGKSSCINCLITSIMCRATPEDVRMVLVDPKRVELTAYEGIPHLITPIITNPKRAAEALQWVVREMDLRYDDLAAFGYRHIDDFNQAIRDGKLKTPEGSERELKTYPYLLVIVDELADLMMVAPRDVEDSIVRITQLARAAGIHLVLATQRPSVDVVTGLIKANVPSRLAFATSSLADSRVILDQPGAEKLIGKGDGLFLPMGANKPTRMQGAFVTEDEIHAVVQHCKDQMAPVFREDVTVGTKQKKEIDEDIGDDLDLLCQAAELVVSTQFGSTSMLQRKLRVGFAKAGRLMDLMESRNIVGPSEGSKARDVLVKPDELDGVLAVIRGEAQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K3L6</accession>
    <name>A0A2M9K3L6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CG723_00065</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000001">
        <property type="protein sequence ID" value="PJN13715.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN13715">
        <property type="protein sequence ID" value="PJN13715"/>
        <property type="gene ID" value="CG723_00065"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PJN13715.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="111" mass="11074" checksum="7C87FA0780CA1193" modified="2018-04-25" version="1">MPAVAFGALWWWGLLRLAFSPDAGAFEGAVAAGGWGLSLLPVHCVPKARAARAVGAVRRGGTSVGAGRSSGTAVGATGADGAAMRARRFAGAGLLTRAWRRRRSGGGSGPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JF52</accession>
    <name>A0A2M9JF52_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Mycofactocin system glycosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">mftF</name>
        <name evidence="2" type="ORF">CG723_44455</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000047">
        <property type="protein sequence ID" value="PJN05499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN05499">
        <property type="protein sequence ID" value="PJN05499"/>
        <property type="gene ID" value="CG723_44455"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023981">
        <property type="entry name" value="MftF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43646:SF6">
        <property type="entry name" value="PTHR43646:SF6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13632">
        <property type="entry name" value="Glyco_trans_2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03965">
        <property type="entry name" value="mycofact_glyco"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_2-like" evidence="1">
        <location>
            <begin position="163"/>
            <end position="349"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN05499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="473" mass="50373" checksum="978CD36EC5845F9B" modified="2018-04-25" version="1">MTLPNGFIVTLDRGTRVLDDGRALLGGQPTRLLRLTPRATALLSGRSLRVRNAASALLADRLLANGMAHPLLTALSDAAVTAEGESSCTYVIPVRDRCRQLARLLACLPSGSPVIVVDDASLAPERVATVAAEHGARLLQLPVNVGPAAARNAGLRQVTTSHVAFVDSDMVLPRETVPALLRHFADPSVAMAVPRIGAMNTDSSGSWISRYEHVRSSLDLGRHPASVRPGSPVSWVPSACIVARVDVLLAAGGFDESLRVGEDVDLCWRLVETGRRIRYEPAVHADHEHRAQLVAWFRRKIDYGTGAHPLAVRHPQDTATAVLAPWSAALLVAVAAQRRWSLPVATALWTTATLRIARTLHGTAHPVSEAARLTAGGAVNALAQGGALLTRHWWPATAVGCLISRRVRRAAAVAAVADMALEYGSHSTSGLGPLRYAAARRLDDLAYGAGVWLSAVRGRSTAALRLRIATRSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JFC0</accession>
    <name>A0A2M9JFC0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_44115</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000045">
        <property type="protein sequence ID" value="PJN05588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN05588">
        <property type="protein sequence ID" value="PJN05588"/>
        <property type="gene ID" value="CG723_44115"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="42"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="63"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN05588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="135" mass="14191" checksum="25D31406DDBE4C5E" modified="2018-04-25" version="1">MRWLRWLVVAVTAGATFWVFLWVAQSVSWGWLPEGEAERWGVAAGFAAVVASAVVMATGWWAGREVSPGQPPSGRSVRGRVADQGRVDQVGGHRGRPSGPSRAVPGSVRLDAEASGHGQIRQTGGDDYTSGPGAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-06-02" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JFM8</accession>
    <name>A0A2M9JFM8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Amidohydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CG723_43570</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000043">
        <property type="protein sequence ID" value="PJN05690.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN05690">
        <property type="protein sequence ID" value="PJN05690"/>
        <property type="gene ID" value="CG723_43570"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016831">
        <property type="term" value="F:carboxy-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032465">
        <property type="entry name" value="ACMSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21240">
        <property type="entry name" value="PTHR21240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04909">
        <property type="entry name" value="Amidohydro_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0456">Lyase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydro-rel" evidence="3">
        <location>
            <begin position="63"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PJN05690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="337" mass="37043" checksum="950E00EA188CE87F" modified="2018-04-25" version="1">MSPRSSGATDLSAESNAESDAANSAENSAANGAEGGADTSTAGVGEADRVARFRERHGLAGLVDVHTHFMPERVLKKVWEYFDAAGPLTGMAWPIAYREEEAQRLARLREFGVEAFTSMLYPHKTGMAEWLNGWAVDFARRTPGCLHTSTFFPEPGVDRYVREAVEAGTRVFKAHVQVGAYDPNDELLDPVWGMLAEARVPVVMHCGSGPAPGKHTGPEPVARLLARHPRLPVIVAHMGMPEYTDFLDLAERYGEVRLDTTMAFTDFSERFSPFPRAELARLADLGDRILLGTDFPNIPYPYVHQLEALERLGLGEEWLRAVCHGNGVRLFGLDPLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JGE2</accession>
    <name>A0A2M9JGE2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CG723_41965</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000038">
        <property type="protein sequence ID" value="PJN05903.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN05903">
        <property type="protein sequence ID" value="PJN05903"/>
        <property type="gene ID" value="CG723_41965"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PJN05903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="191" mass="21717" checksum="753C6F6824E124C7" modified="2018-04-25" version="1">MPDRNLEFGKFGARGIKGYEAAARQLDHLAAFIASPATTRRGMLARLHYLTRTDHARAAAREAGLTVTDRTLKRWAEGKAAPSKKSLAQLEDAYRQVRRHNVARHLLQRLNRQGRGTRVEFHPLNQAQVPRPLQRDVSFRTLNVRHWDRMVQAWAADDDEAMDEAWFDGITVDLGSDYGAYEYVMNIGFAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-09-29" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JGF0</accession>
    <name>A0A2M9JGF0_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Metallophos domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CG723_42595</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000040">
        <property type="protein sequence ID" value="PJN05827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN05827">
        <property type="protein sequence ID" value="PJN05827"/>
        <property type="gene ID" value="CG723_42595"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP_ApaH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="SSF56300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="42"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="148"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="174"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="domain" description="Metallophos" evidence="3">
        <location>
            <begin position="261"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="493"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="505"/>
            <end position="525"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PJN05827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="525" mass="55894" checksum="B15C026EAC6EE0A9" modified="2018-04-25" version="1">MARVPAVAALSALRNIPAAVGRHHRARRPRPTGDLTLQPRPYLRALGLAAVVLMGAWLGLLVVGNVRVPVGPMDTRMTLRPSLTGGTKINVSPLGSLELKSHTAPIRLDVDVDRLDPVRSQALVDHPERLSGLQDEVTRDVEHGTLDLALRSCVAVVSGATALGLAVYRRPRRALGAGGLALALLAASGGAAYATWNPKSVLEPKFSGLLSSAPSVVGNARSIVTEFDVYQKELARLVTNVTKLYDVTSTLPAYRPDPSTIRVLHVSDIHLNPASWKIISSLVKQYDISVIVDSGDTMDHGSAAENPFLDPIKDLGAPYIWVRGNHDSATTQRYLSHIRNVRVLDNGKAVTVAGLRFAGTGDPQYTPDRAVKAQGDPAERMAGIRLASALRDQREAGTPVDIAIAHNPVAARETDGTVPLVLAGHIHHEATEVMKLGTRLRIEGSTGGSGLRAVDDGSPDPVQASVLYLDRDTRRLQAWDEIELGGLGLTTAQVSRHLPKENQPGATPSPTPPTGSPAPSPIRFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JH10</accession>
    <name>A0A2M9JH10_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF4097 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_40510</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000034">
        <property type="protein sequence ID" value="PJN06161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN06161">
        <property type="protein sequence ID" value="PJN06161"/>
        <property type="gene ID" value="CG723_40510"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025164">
        <property type="entry name" value="DUF4097"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13349">
        <property type="entry name" value="DUF4097"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014909410" description="DUF4097 domain-containing protein" evidence="1">
        <location>
            <begin position="32"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4097" evidence="2">
        <location>
            <begin position="46"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN06161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="253" mass="26081" checksum="3851E38CE692C9D3" modified="2018-04-25" version="1">MGIRPHTLLALGGVALLAVAATACTTDGDSANTTVESKSFDFSGNSLTVKSNSADLEFVAADVEGVQVERQVSGTKVGGENDPGWQLEGSTLKLSLDCTGISINCKAKYIVKVPRDVAITAENDKGLIKATGFTADFSAKAGNSDVQLSDLSGAHLDLEGSDGNIKGDRISAKSVTATSRNGDNNLSLASVPTLVDMQSQDGNIKLNLPEATYAVDTAAKKGDITVDVTKGDMSGHVVRAHTRNGDIVIGKAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-09-29" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JH95</accession>
    <name>A0A2M9JH95_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Alpha-ketoglutarate-dependent dioxygenase AlkB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CG723_40155</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CB01635</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000033">
        <property type="protein sequence ID" value="PJN06235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN06235">
        <property type="protein sequence ID" value="PJN06235"/>
        <property type="gene ID" value="CG723_40155"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.590">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004574">
        <property type="entry name" value="Alkb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027450">
        <property type="entry name" value="AlkB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037151">
        <property type="entry name" value="AlkB-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16557">
        <property type="entry name" value="PTHR16557"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13532">
        <property type="entry name" value="2OG-FeII_Oxy_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 7" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="2" id="KW-0227">DNA damage</keyword>
    <keyword evidence="5" id="KW-0234">DNA repair</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="6">
        <location>
            <begin position="123"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PJN06235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="238" mass="25879" checksum="2D0BBBC8DF724555" modified="2018-04-25" version="1">MARRHEPHAPPLFPVHRERREITPGAVHVPGWLDAEARRALVEACRGWAAGPVPMRHTRLPGGGVMSVQTVCVGWHWQPYRYTRTASDVNGAPVAHFPDWLQELGRRALVDAYEDDTAGDGYAPDTALINFYDGAATMGMHQDKDERAREPVVSLSIGDTCVFRLGNTENRGRPYEDVELVSGDLLVFGGPSRLAFHGVPKVYPGTGDPATGLSRGRLNLTMRVTGLTAPPSAPSPQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JHE4</accession>
    <name>A0A2M9JHE4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycosyl transferase family 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_40305</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000033">
        <property type="protein sequence ID" value="PJN06263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN06263">
        <property type="protein sequence ID" value="PJN06263"/>
        <property type="gene ID" value="CG723_40305"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017832">
        <property type="entry name" value="Glyco_trans_2_hopen-assoc_HpnB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03469">
        <property type="entry name" value="HpnB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="282"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="340"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_trans_2-like" evidence="2">
        <location>
            <begin position="45"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN06263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="391" mass="42262" checksum="DFE8C882FEC52B92" modified="2018-04-25" version="1">MDAVVWITAASLAAWVWLLAGQGFFWRTNLRLPPRTDPAEWPKVCVVVPARDEAAVLPDSLPSLLAQDYPGRAEVFLIDDGSTDGTGTLARELAVRHGGLPLTVGSPGEPPAGWTGKLWAVRHGIGLARAREPEYLLLTDADIAHEPESLRELVAAARTGGFDLVSQMARLRVESVWERLVVPAFVYFFAQLYPFRWIARKGSRTAAAAGGCVLLSAGATERAAIPDSIRHAVIDDVALARAVKGAGGHIWLGLADRVDSVRPYPRLGDLWRMVSRSAYAQLRHNPLLLAGTVAGLALVYLAPPVALVAGLATGHGLTALLGGLAWLLMTATYAPMLRYYAQPLWLAPLLPGTAFLYLLMTVDSAVQHYRGRGAAWKGRTYSRPHPAPERQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JHG3</accession>
    <name>A0A2M9JHG3_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Malonyl CoA-acyl carrier protein transacylase</fullName>
            <ecNumber evidence="3">2.3.1.39</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">fabD</name>
        <name evidence="6" type="ORF">CG723_39980</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CB01635</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 3">
            <text>holo-[ACP] + malonyl-CoA = CoA + malonyl-[ACP]</text>
            <dbReference type="Rhea" id="RHEA:41792"/>
            <dbReference type="Rhea" id="RHEA-COMP:9623"/>
            <dbReference type="Rhea" id="RHEA-COMP:9685"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57384"/>
            <dbReference type="ChEBI" id="CHEBI:64479"/>
            <dbReference type="ChEBI" id="CHEBI:78449"/>
            <dbReference type="EC" id="2.3.1.39"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the fabD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.39" evidence="3"/>
    <dbReference type="EMBL" id="NNBL01000032">
        <property type="protein sequence ID" value="PJN06324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN06324">
        <property type="protein sequence ID" value="PJN06324"/>
        <property type="gene ID" value="CG723_39980"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004314">
        <property type="term" value="F:[acyl-carrier-protein] S-malonyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.366.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001227">
        <property type="entry name" value="Ac_transferase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014043">
        <property type="entry name" value="Acyl_transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024925">
        <property type="entry name" value="Malonyl_CoA-ACP_transAc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004410">
        <property type="entry name" value="Malonyl_CoA-ACP_transAc_FabD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016036">
        <property type="entry name" value="Malonyl_transacylase_ACP-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00698">
        <property type="entry name" value="Acyl_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000446">
        <property type="entry name" value="Mct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00827">
        <property type="entry name" value="PKS_AT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="SSF52151"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55048">
        <property type="entry name" value="SSF55048"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00128">
        <property type="entry name" value="fabD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PKS_AT" evidence="5">
        <location>
            <begin position="6"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="active site" evidence="4">
        <location>
            <position position="88"/>
        </location>
    </feature>
    <feature type="active site" evidence="4">
        <location>
            <position position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR000446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000446-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PJN06324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="296" mass="31850" checksum="0AE56C9A3DF57E2B" modified="2018-04-25" version="1">MTRIFMFPGQGAQSVGMGRELFARFPDAEQEAADVLGYSLRRLCLEDPEGQLGNTRYTQPALFVVNALAHRAHLEDGGERPDLAVGHSLGEYNALHAAGAFGFADGLRLVAARAAAMAEITGGGMSAVIGLPESQLRFLLLRAGFGSLDLANLNTPGQIVLAGPADDLAEAGPILEDAGARMVRRLDVSGPFHSRYMTPAAESLGPVVRATPFRPLAYPVIANATARPYEHHRIGETLLQQIHQPVRWHETVEAILTGVYGPEPEFTEIGTGRVLAGMLRQIRRERDQLLTGAGTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JHL5</accession>
    <name>A0A2M9JHL5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alkanesulfonate monooxygenase</fullName>
            <ecNumber evidence="2">1.14.14.5</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_39620</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.14.5" evidence="2"/>
    <dbReference type="EMBL" id="NNBL01000031">
        <property type="protein sequence ID" value="PJN06369.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN06369">
        <property type="protein sequence ID" value="PJN06369"/>
        <property type="gene ID" value="CG723_39620"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008726">
        <property type="term" value="F:alkanesulfonate monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011251">
        <property type="entry name" value="Luciferase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036661">
        <property type="entry name" value="Luciferase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00296">
        <property type="entry name" value="Bac_luciferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51679">
        <property type="entry name" value="SSF51679"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bac_luciferase" evidence="1">
        <location>
            <begin position="7"/>
            <end position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN06369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="393" mass="42539" checksum="BC312D746B6EA593" modified="2018-04-25" version="1">MSVHLHWFLPTGGDGRTLVDRHAYTDGGVKRSRIAPVSGVRAPDIDYLTQIAKAAEQLGFEAVLTPTGTWCEDAWLTTVALAQHTKRLKFLVAFRPGVISPVLAAQMAATYQRITRGRLLLNVVTGGDSTEQRRFGDHLDHDRRYARTDEFLSVVRGVWSGQPFDFDGEHYQVEGGLTALPPDPLPEIFFGGSSAAAGPVAARHTDVYLTWGEPPEQVKQKIDWIRGLAEKEGRTVRFGIRLHTISRDSSAEAWATANRLLDDLSPETVAAAQEALGRSESVGQQRMLALHGGSRDDLEISPNLWAGVGLVRGGAGTALVGSHSDVADRIEEYHALGVEHFVLSGYPHLEEAYWFGEGVIPDLAARGLLPRTPASPLTRPAVGGAPLLVAGGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JHP0</accession>
    <name>A0A2M9JHP0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Curamycin polyketide synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CG723_40390</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000033">
        <property type="protein sequence ID" value="PJN06277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN06277">
        <property type="protein sequence ID" value="PJN06277"/>
        <property type="gene ID" value="CG723_40390"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="SSF47336"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="4">
        <location>
            <begin position="5"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="3">
        <location>
            <position position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PJN06277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="86" mass="9220" checksum="99793578C042D941" modified="2018-04-25" version="1">MITAELTFDELARLMKKAAGVTVDPHLLKQSPDSPFDSVGLDSLGLLGIVGELENRSGQPLPPDSERCKTPREFLDLVNSTLKAGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JHZ2</accession>
    <name>A0A2M9JHZ2_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Glycine cleavage system H protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3 6" type="primary">gcvH</name>
        <name evidence="6" type="ORF">CG723_38835</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CB01635</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>(R)-lipoate</name>
            <dbReference type="ChEBI" id="CHEBI:83088"/>
        </cofactor>
        <text evidence="3">Binds 1 lipoyl cofactor covalently.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">The glycine cleavage system is composed of four proteins: P, T, L and H.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the GcvH family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000029">
        <property type="protein sequence ID" value="PJN06501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN06501">
        <property type="protein sequence ID" value="PJN06501"/>
        <property type="gene ID" value="CG723_38835"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005960">
        <property type="term" value="C:glycine cleavage complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019464">
        <property type="term" value="P:glycine decarboxylation via glycine cleavage system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06848">
        <property type="entry name" value="GCS_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00272">
        <property type="entry name" value="GcvH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003016">
        <property type="entry name" value="2-oxoA_DH_lipoyl-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000089">
        <property type="entry name" value="Biotin_lipoyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002930">
        <property type="entry name" value="GCV_H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033753">
        <property type="entry name" value="GCV_H/Fam206"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017453">
        <property type="entry name" value="GCV_H_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011053">
        <property type="entry name" value="Single_hybrid_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11715">
        <property type="entry name" value="PTHR11715"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01597">
        <property type="entry name" value="GCV_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51230">
        <property type="entry name" value="SSF51230"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00527">
        <property type="entry name" value="gcvH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50968">
        <property type="entry name" value="BIOTINYL_LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00189">
        <property type="entry name" value="LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 4" id="KW-0450">Lipoyl</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lipoyl-binding" evidence="5">
        <location>
            <begin position="23"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-lipoyllysine" evidence="3 4">
        <location>
            <position position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR617453-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PJN06501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="127" mass="13509" checksum="14A3F840E73C7B68" modified="2018-04-25" version="1">MSNPQQLRYSKEHEWLSGAEDGVSTVGITEFAANALGDVVYAQLPEVGDTVTAGETCGELESTKSVSDLYSPVTGEVVEANQDVVDDPSLVNSAPFEGGWLFKVRTSEEPKDLLSADEYDAFSGSGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JIA9</accession>
    <name>A0A2M9JIA9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CG723_37710</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000027">
        <property type="protein sequence ID" value="PJN06625.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN06625">
        <property type="protein sequence ID" value="PJN06625"/>
        <property type="gene ID" value="CG723_37710"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012467">
        <property type="entry name" value="DUF1684"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41913">
        <property type="entry name" value="PTHR41913"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07920">
        <property type="entry name" value="DUF1684"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PJN06625.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="259" mass="28070" checksum="C468359ADFCECE67" modified="2018-04-25" version="1">MTDDAAGAWQQWHEQRTASVSEPYGPLALTGTHWLDDYPEGTLPAIPGKWRADGGQVVLTAAPEDGLTRDGQPLTGEVRLTADARIGLGERRLVVIVREGLWAVRDFDPQSGPRRDFGGIEATGHDPRWTVEGRFTPYEESRTVRVENADGKERGLGLGGELAFSLDGQDLTLQVAVQADGSLWAVFADATSGDGTFRFRFLRPAAPDAEGRTSVDFNRAVLPPCAFADHFVCPFPPPGNTLPVKIEAGERNLVGRHSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-05-25" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JIP8</accession>
    <name>A0A2M9JIP8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Cold-shock protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CG723_37345</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CB01635</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000026">
        <property type="protein sequence ID" value="PJN06749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006138897.1">
        <property type="nucleotide sequence ID" value="NZ_NNBL01000026.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN06749">
        <property type="protein sequence ID" value="PJN06749"/>
        <property type="gene ID" value="CG723_37345"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04458">
        <property type="entry name" value="CSP_CDS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012156">
        <property type="entry name" value="Cold_shock_CspA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011129">
        <property type="entry name" value="CSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019844">
        <property type="entry name" value="CSD_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002059">
        <property type="entry name" value="CSP_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00313">
        <property type="entry name" value="CSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002599">
        <property type="entry name" value="Cold_shock_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00050">
        <property type="entry name" value="COLDSHOCK"/>
    </dbReference>
    <dbReference type="SMART" id="SM00357">
        <property type="entry name" value="CSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00352">
        <property type="entry name" value="CSD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51857">
        <property type="entry name" value="CSD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CSD" evidence="3">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU000408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PJN06749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="67" mass="7149" checksum="F3ED82F6CAA8CA6C" modified="2018-04-25" version="1">MATGTVKWFNAEKGFGFIAQEGGGPDVFVHYSAINANGFRSLEENQAVSFDVTQGPKGPQAENVTPM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JIP9</accession>
    <name>A0A2M9JIP9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CG723_37200</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000026">
        <property type="protein sequence ID" value="PJN06723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN06723">
        <property type="protein sequence ID" value="PJN06723"/>
        <property type="gene ID" value="CG723_37200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd07067">
        <property type="entry name" value="HP_PGM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00300">
        <property type="entry name" value="His_Phos_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00855">
        <property type="entry name" value="PGAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="SSF53254"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PJN06723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="231" mass="25524" checksum="6AB030C084D8C73B" modified="2018-04-25" version="1">MTTAGKSDQDITVVHVMRHGEVHNPEGILYGRLPDYHLSELGRQMADRVAEHLSSRDVTHVVASPLDRAQETATPIAKAHGLDLATDDRLIEAGNVFQGKTFGVGDGALRKPENWKHLVNPFKPSWGEPYVEQVVRMMGALDAAKDAARGHEAVCVSHQLPIWIVRSFVEKRRLWHDPRKRQCTLASLTTFTYRGDKIVSVGYTEPARDLVPAHLLAGAKPVKGKDKAFGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JIR9</accession>
    <name>A0A2M9JIR9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DNA-binding response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CG723_37965</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000027">
        <property type="protein sequence ID" value="PJN06667.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN06667">
        <property type="protein sequence ID" value="PJN06667"/>
        <property type="gene ID" value="CG723_37965"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="4"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="domain" description="HTH luxR-type" evidence="3">
        <location>
            <begin position="149"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PJN06667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="220" mass="23436" checksum="66EC60E5EEA47E66" modified="2018-04-25" version="1">MTVRVVLADDQPLVRSGLRVLIADTPDLEVVGEAANGEEAVRLAKEVSPDVIVMDIRMPGMNGIEATNLVTSGAGATRVLVLTTFDEDDHVYGALRAGASGFAVKDMALDDILAAIRVVAAGDALIAPGITRRLIADFVRRPEPSPARASRPVEGITEREREVLTLVGLGRSNSEIADELYITVATTKSHVARLFTKLGARDRVQLVIIAYESGLVSAPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-05-25" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JIV0</accession>
    <name>A0A2M9JIV0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">NADH-quinone oxidoreductase subunit L</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CG723_37655</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CB01635</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5">Membrane</location>
            <topology evidence="1 5">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000026">
        <property type="protein sequence ID" value="PJN06801.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN06801">
        <property type="protein sequence ID" value="PJN06801"/>
        <property type="gene ID" value="CG723_37655"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042773">
        <property type="term" value="P:ATP synthesis coupled electron transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018393">
        <property type="entry name" value="NADHpl_OxRdtase_5_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001750">
        <property type="entry name" value="ND/Mrp_mem"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003945">
        <property type="entry name" value="NU5C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001516">
        <property type="entry name" value="Proton_antipo_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42829">
        <property type="entry name" value="PTHR42829"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00361">
        <property type="entry name" value="Proton_antipo_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00662">
        <property type="entry name" value="Proton_antipo_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01974">
        <property type="entry name" value="NDH_I_L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="36"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="76"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="112"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="137"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="169"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="201"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="245"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="269"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="303"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="327"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="373"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="420"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="464"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="496"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="641"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="domain" description="Proton_antipo_N" evidence="8">
        <location>
            <begin position="68"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="domain" description="Proton_antipo_M" evidence="7">
        <location>
            <begin position="132"/>
            <end position="404"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PJN06801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="664" mass="68330" checksum="C4BBEF79035B97F9" modified="2018-04-25" version="1">MTTTTLAVLVPLLPFLAAAAGLLLGRTAPGFVRPLAVLPTLAALVLAVLVAVRQGGGRSIDAATELTPTGSVPIELALHIDGFAALVAVLVCVVASCVQIYSTAYLRDDPRYPSYAALVSLFTSAMLLVVYSGDLMVLLVGWEVMGICSYFLVGHYWETPEARAASLKAFLVTKLGDVPFLIGLFALAVDAGSFRITTVLGAVASGGLDHPTLIALLLLAGVAGKSAQFPLHTWLPDAMAGPTPVSALIHAATMVAAGVYFVARLLPVFAASGAALVVLAVMAAVTMTGSALAALAQDDIKRVLAYSTIGQLGYMTGALAVGDRGAAVFHLLSHGAFKALLFLGAGVVIHAAGTNSLAAMSRMKDLRDRVPDAYWTMTVALLALAAIPPFSGFFSKEAVLGSAEHAATGHAEAIPSSAGWIVLVSGLLTALLTAAYATRLWLLAFRGHGAEAPDHGRQPVAMNAVLWVLAIPSLAFGLTVGVLPDWFDGRSLTPTLTTSVLGTGVALVGGIVTYAAWRHTTALAARVPLGAVAAHPDADGGLVEAEAIATHTAAYGDIAYAPDPADPGRLLLGPLHRHAATGFHLDAVYAVLFVRPVLAAASLVRFLDREVVETYVRGAAAVPNWLGRAVRRAQTGNVQTYLSALLAGTVVLAIAVVLVATAGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JIV3</accession>
    <name>A0A2M9JIV3_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CHRD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_37545</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000026">
        <property type="protein sequence ID" value="PJN06782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN06782">
        <property type="protein sequence ID" value="PJN06782"/>
        <property type="gene ID" value="CG723_37545"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010895">
        <property type="entry name" value="CHRD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021851">
        <property type="entry name" value="DUF3455"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07452">
        <property type="entry name" value="CHRD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11937">
        <property type="entry name" value="DUF3455"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00754">
        <property type="entry name" value="CHRD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50933">
        <property type="entry name" value="CHRD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014955080" description="CHRD domain-containing protein" evidence="1">
        <location>
            <begin position="37"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="domain" description="CHRD" evidence="2">
        <location>
            <begin position="65"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN06782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="337" mass="34646" checksum="6778BD0167E87781" modified="2018-04-25" version="1">MGTLGTNSKRRKTLVLTGVAAAAAAGVTAAVLPAVADNGEREGSGHAAHGVQSLDAHGSLSGGRGGALFAAGLRGAAEVPVKGGPAVGDKDGAALEFIKVKGDRVSVAVKWRGTAKPTMLHIHEGAKGTNGGVKVDFTGLLGRIRNHQVTGSVTVKDRALLGRLTKNPGGFYANLHTAEFPGGAVRGQLHKVSTDFAFRDALSHVQASVVRGRQIYQCRKADDGSGTYAFAQRDVRAVLGGNIAHTFTAPNSGTPQWTAPDRSAVTGKLISKTPNGDGNIPELDLRATQTGKRHGLLSGTAEILRLNTVGGVAPAGSCDPGTVVGVPYRADYVFVQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JJE5</accession>
    <name>A0A2M9JJE5_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Alpha-galactosidase</fullName>
            <ecNumber evidence="5">3.2.1.22</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Melibiase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CG723_36555</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CB01635</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>Hydrolysis of terminal, non-reducing alpha-D-galactose residues in alpha-D-galactosides, including galactose oligosaccharides, galactomannans and galactolipids.</text>
            <dbReference type="EC" id="3.2.1.22"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the glycosyl hydrolase 27 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.22" evidence="5"/>
    <dbReference type="EMBL" id="NNBL01000024">
        <property type="protein sequence ID" value="PJN06995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN06995">
        <property type="protein sequence ID" value="PJN06995"/>
        <property type="gene ID" value="CG723_36555"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052692">
        <property type="term" value="F:raffinose alpha-galactosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14792">
        <property type="entry name" value="GH27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002241">
        <property type="entry name" value="Glyco_hydro_27"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041233">
        <property type="entry name" value="Melibiase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11452">
        <property type="entry name" value="PTHR11452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16499">
        <property type="entry name" value="Melibiase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17801">
        <property type="entry name" value="Melibiase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00740">
        <property type="entry name" value="GLHYDRLASE27"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4 5" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014825388" description="Alpha-galactosidase" evidence="6">
        <location>
            <begin position="32"/>
            <end position="699"/>
        </location>
    </feature>
    <feature type="domain" description="Melibiase_C" evidence="7">
        <location>
            <begin position="357"/>
            <end position="428"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU361168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF17801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PJN06995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="699" mass="73932" checksum="4F1B23D42179D028" modified="2018-04-25" version="1">MTSPRAATTGTATLAALLVAAVLSPAVPVAAADRPAASHEPTPTSLAPTPYMGWNTYFGLGAPTEKDVKSVADFLVSSGLKKSGYDIVWLDGGWQADTPRDAEGHLAANRERFPSGIPSLVDYLHRRGLKAGIYTDAGTYDGGKSCGLGSRGHYTEDARQFADWKVDAIKVDFLCGIAEKADPEPAFKEFSAAVRKTGRPMLLNLCNPLTDDWGVPHTPAQDAHNSYRFGPRLADSWRTGTDVAWGTPHENQWPNILRNMDANMAHPEAQTPGHYNDPDYLIPLRKLEDGTPELTTEESTTQLVMWALMGSPLVIGSDPRTLPQDMIDTLRNPEIIDVDQDPLAVQGVRVASDATGDVYSKVLQGAGHRAVALLNRSDKAARLTVDFADAGLTGPVRVRDLRARADRGVHDSSYTVEVPGHGTAFLKLDGKDTAPGTRLGVRSPADPAAVGDDVFSTTTSGTVVENGTSLGRPGDGRVTGRPVARANGKGRTEVYVRATDGHLYRRQITDGRAVGDWRRVSGPAVSSAPATAGTGTAPDTLAVRGEDGGLLVRSAAGDWQRLGTPDGLGLYDDPAAVTDADGHVHVAVRATDSAVWTRVRDTDGSWSPWASLGGATSASPALALDGDTVRLVSRAGDYTVWQRSLAAGQGDDAWSGWSKRTEFASAALAGTPSLTGTPLTATFRGVDGQLWQAPLPASD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JJE9</accession>
    <name>A0A2M9JJE9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CG723_36545</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CB01635</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000024">
        <property type="protein sequence ID" value="PJN06993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN06993">
        <property type="protein sequence ID" value="PJN06993"/>
        <property type="gene ID" value="CG723_36545"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="31"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="98"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="129"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="179"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="284"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="92"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PJN06993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="314" mass="34473" checksum="13972C9F8EF75E98" modified="2018-04-25" version="1">MALLDTDTRPAAGPRKTSSARRPRRGAATRVPPLVVAFVLVPLLAEGFWVFWPALQGFYLAITDWDGISAAHLIGLGNFREMAHDTVFWHALANTAKWLVLFGGLSAVLGLGAALLLQQERRGVGFYRAALFLPVVFSLVATALVWQAMYQPDGLINQVLEGVGLDNLTRSWLADRDTALYAVLLPALWRQIGYVMVLYLAGLKGIDPMLYEAAKVDGASRLQQFRHVTLPQLKSVNAVVLSVIIIDSLRSFDVVWSLTRGGPYHSSELLSTYMYSTAFQSLRLGYGSALAVVIFLLAFGVIASYLVRAFREAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JJF6</accession>
    <name>A0A2M9JJF6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">GntR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CG723_36485</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000024">
        <property type="protein sequence ID" value="PJN06982.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN06982">
        <property type="protein sequence ID" value="PJN06982"/>
        <property type="gene ID" value="CG723_36485"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07377">
        <property type="entry name" value="WHTH_GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.530">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011711">
        <property type="entry name" value="GntR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008920">
        <property type="entry name" value="TF_FadR/GntR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07729">
        <property type="entry name" value="FCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
        <property type="entry name" value="GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00035">
        <property type="entry name" value="HTHGNTR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00895">
        <property type="entry name" value="FCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00345">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48008">
        <property type="entry name" value="SSF48008"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50949">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH gntR-type" evidence="4">
        <location>
            <begin position="11"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PJN06982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="218" mass="23566" checksum="86E9182443772E97" modified="2018-04-25" version="1">MALGPIEIDRSSTVDRVAHALREEMYRGTLTGGTSLRESNVAESLGVSRSTVREALQILTSEGLLVRRPNRGVEVRQLTEEEIEDIFKARRVLETAAARSVVQATRTDLMTLIAVQRDFEEAVASSAAASVVTEAHLAVHVAIVGLLGSPRLTATARDLMSEIKLAVATTDRTSDDLPAQVEQHRAIVELLRQAKGEEAAQLLEAHLAHAKAFMPTVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JJK9</accession>
    <name>A0A2M9JJK9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CG723_35630</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CB01635</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 3">Belongs to the DedA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000023">
        <property type="protein sequence ID" value="PJN07065.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN07065">
        <property type="protein sequence ID" value="PJN07065"/>
        <property type="gene ID" value="CG723_35630"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032818">
        <property type="entry name" value="DedA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032816">
        <property type="entry name" value="SNARE_assoc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30353">
        <property type="entry name" value="PTHR30353"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09335">
        <property type="entry name" value="SNARE_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="53"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="122"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="148"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="182"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="206"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU367016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PJN07065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="230" mass="24914" checksum="2346E5D16BCCB514" modified="2018-04-25" version="1">MTTLALGPSWLDPDHLLNTFGIWGLLLIVFAESGLLIGFFLPGDSLLFTCGLLITAGTLDFPLWGAVGLICVAAILGDQAGYLFGKKVGPSLFNRPDSRLFKQENVVKAHEFFEKYGPKSLVLARFVPIVRTFTPIIAGVSGMKYRSFITFNIIGGVLWGAGVTLLGSWLGNIEFVHKNIEAILILIVLISVVPIAIEFLRARSKSKKAAAATPQPQTPAPGQRGRHAKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JJL9</accession>
    <name>A0A2M9JJL9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DUF4440 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_35690</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000023">
        <property type="protein sequence ID" value="PJN07075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN07075">
        <property type="protein sequence ID" value="PJN07075"/>
        <property type="gene ID" value="CG723_35690"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037401">
        <property type="entry name" value="SnoaL-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13474">
        <property type="entry name" value="SnoaL_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="SSF54427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SnoaL-like" evidence="2">
        <location>
            <begin position="23"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13474"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN07075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="183" mass="19968" checksum="8403D1BFAF994247" modified="2018-04-25" version="1">MTPPREPDEPRGAAGRRTDAEAVDSANRAFYEALERADFELLTALWLAPEDVSYSEESDEAEDTSISCVHPGWPVLTGRGEVLRSYALIMANTEYIQFFLTDVHISIVADTALITCTENILSGGPAPAEGDELGPLVGQRVVATNVFRRTRDGWKLWSHHASPVLAESETEGDDGEESDETSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-09-29" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JJM9</accession>
    <name>A0A2M9JJM9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Esterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_35705</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000023">
        <property type="protein sequence ID" value="PJN07078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN07078">
        <property type="protein sequence ID" value="PJN07078"/>
        <property type="gene ID" value="CG723_35705"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000801">
        <property type="entry name" value="Esterase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00756">
        <property type="entry name" value="Esterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="41"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN07078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="371" mass="40138" checksum="11B0EC77DBC7C97A" modified="2018-04-25" version="1">MGLTSSKVLTLAVFLAVLLFAGTVWLWPRLACRTWGSVAGRVGLLFATQLALFLSAVLAVNQAFGFYASWDDLLGREQGQGVVADFGAVGTRGPLQVLGTRVVNVPGGSRPRVGGQIQKVDIVGKRSHIATSAYVYLPPEYFKGRHKTRTFPASVVLTGYPGTAEALIKGLRYPTTAHEQARAGAMRPMILVMMRPTVAPPRDTECVDVPNGPQTETFFAQDLPRIISAHYRVNKRPGGWGIVGDSTGGYCALKLAVHHPRVYGAGAGLSAYYKSPTDPTTGDLFHGDEALERRADLMWTLGHGKPPATSLLVTTSKHGESNYGNTMRFIREVKPPTEISSIVLDSGGHNFNTWRREIPATLVWLSARITA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-05-25" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JK81</accession>
    <name>A0A2M9JK81_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Endolytic murein transglycosylase</fullName>
            <ecNumber evidence="7">4.2.2.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Peptidoglycan polymerization terminase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">mltG</name>
        <name evidence="9" type="ORF">CG723_34100</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CB01635</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cell membrane</location>
            <topology evidence="7">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the transglycosylase MltG family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.2.-" evidence="7"/>
    <dbReference type="EMBL" id="NNBL01000021">
        <property type="protein sequence ID" value="PJN07289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN07289">
        <property type="protein sequence ID" value="PJN07289"/>
        <property type="gene ID" value="CG723_34100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008932">
        <property type="term" value="F:lytic endotransglycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02065">
        <property type="entry name" value="MltG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003770">
        <property type="entry name" value="MLTG-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30518">
        <property type="entry name" value="PTHR30518"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02618">
        <property type="entry name" value="YceG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00247">
        <property type="entry name" value="TIGR00247"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 7" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="5 7" id="KW-0456">Lyase</keyword>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="191"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="21"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="site" description="Important for catalytic activity" evidence="7">
        <location>
            <position position="420"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PJN07289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="543" mass="59199" checksum="3E952B14B36F87A5" modified="2018-04-25" version="1">MYGDQGWGQQAADGQPVYGGQGQYHPQQPQQHPQAQQPQQYGGEWGTGQHDQYGQQQYGGGQQYGGQQQGGGQQYGGQQQGGGWDTGQHGHVPYNADPVDPYGGQQQPVAYGGEQPDLYGTPDAYPPPEPPGRRGSAAEPETNWDPGPDQGEHAFFAGGGDDDGDDYDDPSDRGSRRGRGGKKPKKRRSGCACLVLTVIFAGGVGGVGYFGYQFYQDRFGSAPDYAGSGNGEPVSVDIPKGAGGYVIGQRLKDAGVIKSVDAFVSAQEQNPRGKSIQDGGYNLEKEMSAESALEMMLSPSSRNNLIIAEGRRNVWVYEQVDERLGIAKGTTQKVAQKDYKKLGLPSWAMNEPNVKDPLEGFLYPSSYGVAKGENPETVLKQMVSRATETYEDYGVEKKAKSLGLDSPWQLITVASLAQAEGTSHDDFRKMAEVVYNRLKPGNVQTNGMLEFDSTYNYVKNQSKIDLSLTALRKYDNRYNTYYYKGLPPGPIGNPGEEALKGAVDPTSDGWYYFISMDGKTSEFTKTNAEHQKLVDKWNASRKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JKH0</accession>
    <name>A0A2M9JKH0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Glycosyl transferase family 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CG723_34495</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000021">
        <property type="protein sequence ID" value="PJN07362.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN07362">
        <property type="protein sequence ID" value="PJN07362"/>
        <property type="gene ID" value="CG723_34495"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044249">
        <property type="term" value="P:cellular biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901576">
        <property type="term" value="P:organic substance biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028098">
        <property type="entry name" value="Glyco_trans_4-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13439">
        <property type="entry name" value="Glyco_transf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_4-like_N" evidence="4">
        <location>
            <begin position="14"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="domain" description="Glycos_transf_1" evidence="3">
        <location>
            <begin position="190"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PJN07362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="374" mass="39121" checksum="98F3CBA2A01232B7" modified="2018-04-25" version="1">MRVVIVTESFPPDINGVAHCALQTARHLAARGHDPLVIAPATAPGPDTDTDAPCPVVRVPSLPLPGYPQVRVALPSRRVAAAVAAHGAELVHLASPFILGVRGMAAASRLRIPAVAVYQTDLAGYARTYMGAGEATAWRRIRSVHGAADRTLAPSSAAVHDLEVHGVPRVRLWPRGVDTVRFRPDLRDEALRRELAPNGELIVGYVGRLAPEKQVDLLAGACALDGVRVVIVGDGPSEPGLREALPGAVFLGRRTGAELARIFASLDIFAHTGPYETFCQTVQEAMASGVPVIAPAAGGPLDLVAHSRTGLLVAPGDPAAVRDAVWSLAADPLRRLAYGAAGRSAVEGRTWAAVGDQLVGHYEEVLDARTAVAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JKK5</accession>
    <name>A0A2M9JKK5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CG723_34330</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CB01635</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the nicotinamide ribonucleoside (NR) uptake permease (TC 4.B.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000021">
        <property type="protein sequence ID" value="PJN07401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN07401">
        <property type="protein sequence ID" value="PJN07401"/>
        <property type="gene ID" value="CG723_34330"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034257">
        <property type="term" value="F:nicotinamide riboside transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006419">
        <property type="entry name" value="NMN_transpt_PnuC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36122">
        <property type="entry name" value="PTHR36122"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04973">
        <property type="entry name" value="NMN_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="16"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="106"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="137"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="172"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PJN07401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="214" mass="23551" checksum="1D95BA4B71CB94ED" modified="2018-04-25" version="1">MNWLNSEAFTLFGQHIMWSDMIGNTVGLVALALGWRRSIWTWPAQLVSGLILLTAFATAHLSGSAGKQLVVIVVAAWGWWQWSRGKGQAQDGSLAVRFATWRERGYLLGAAALGTLAVGGLFTAFPTLSWDPWPDAYIFVGTIVAMYAQARGMVEFWFAWLLVDLVGVPLNFANGFAFSGFVYVIYGALVLWGMRDWWLRSRSASQPALEGAPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-09-29" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JKK9</accession>
    <name>A0A2M9JKK9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cytochrome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_33420</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000020">
        <property type="protein sequence ID" value="PJN07408.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN07408">
        <property type="protein sequence ID" value="PJN07408"/>
        <property type="gene ID" value="CG723_33420"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002397">
        <property type="entry name" value="Cyt_P450_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00359">
        <property type="entry name" value="BP450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="SSF48264"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN07408.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="414" mass="45184" checksum="05B5CD94A89F3C3F" modified="2018-04-25" version="1">MTDATPPPGCPAHSGAVALSGLEYQQTPSELYRSLRREHGAIAPVLLDGDIPAWLVLGYPEVTYVTSHDELFARDSRRWNQWEHIPADWPLMPFVGYQPSVLFTEGAEHQRRAGVITEALEAVDQFELARDCERIADQLIDAFAGSGRAELMGAFAHALPMRAAVQFCGMPAGSTDTEQLVDDLRISLDAAEGDDPVAAYGRVGARIQQLVKEKRESPGPDVTSRMLAHPAGLTDEEVVQDLISVIAAAQQPTANWICNTLRLLLTDERFALNVSGGRLSVGQALNEVLWLDTPTQNFIGRWAVRDTQLGGRQIRAGDCLVLGLAAANTDPQIWPESQVGAENSAHLSFSNGEHRCPYPAPLLADVIARTAVETLLERLPDLVLAVEPSELTWRPSIWMRGLTALPVQFTPVSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JKL0</accession>
    <name>A0A2M9JKL0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Dynein regulation protein LC7</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_33435</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000020">
        <property type="protein sequence ID" value="PJN07411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN07411">
        <property type="protein sequence ID" value="PJN07411"/>
        <property type="gene ID" value="CG723_33435"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004942">
        <property type="entry name" value="Roadblock/LAMTOR2_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03259">
        <property type="entry name" value="Robl_LC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00960">
        <property type="entry name" value="Robl_LC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Robl_LC7" evidence="1">
        <location>
            <begin position="9"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN07411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="139" mass="14658" checksum="4418354065DCB57C" modified="2018-04-25" version="1">MRTTDNSLTWLLESLLDRTPGTRHALVLSRDGLKLCWSEHLTLDQADQLAAICSGIQALAQGASVEFGDGTGGVRHSMTEFHGGLLFIVEAGEGAHLAVIAEDGADPGVVGHQMSELVEQIGEHLRAEPRTGDGESASS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JKX0</accession>
    <name>A0A2M9JKX0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Choline dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_33670</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000020">
        <property type="protein sequence ID" value="PJN07519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN07519">
        <property type="protein sequence ID" value="PJN07519"/>
        <property type="gene ID" value="CG723_33670"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007867">
        <property type="entry name" value="GMC_OxRtase_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05199">
        <property type="entry name" value="GMC_oxred_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GMC_oxred_C" evidence="2">
        <location>
            <begin position="359"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="409"/>
            <end position="428"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN07519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="492" mass="52240" checksum="D7FFD23E9D4AB6EC" modified="2018-04-25" version="1">MGAGVARLVRDALPTARILMLDSGPVLGPVPGQHLHDMPDGELRLRHQERIASGVQGMYVGAENVADDAGVGVADREPGMYRLAGVGEDADALPAAALAWNTGGMSVHWTAATPAAWGSEIPDFIDPDAWQRDINEASRFLHVNTDPIGPSPLRTALMGALNEVFGPHAEPGRQVQALPMAVNEDGEGALVRTGPNRVFPAIAGGDPHFELRTGAQVMRLLHKGGTVGGAVVREIATGREYTVTAAATVVCADVFRTPQLLFASGIRPRALGRHLNEHIFQTGRVHVDPDAVGLDGAKLAGATLRDGSEWRHASYWLPHSGKAQPFNGQFSGTARVDGDGRIAEFSAGIALYVPTEIQETNRVEFSDTELDALGMPKMHVVFDYTDEDRRLLDEARAAQLRAGRRLGRFDPATDSETLPPGTSLHMTGTVRMGPADDGTSVCDPQTRVWDFDNLYLAGCGVVPTALVCNSTLTGAVTAVRAARSVIGRLSAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JKX9</accession>
    <name>A0A2M9JKX9_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">MPAB_Lcp_cat domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_33975</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000020">
        <property type="protein sequence ID" value="PJN07531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN07531">
        <property type="protein sequence ID" value="PJN07531"/>
        <property type="gene ID" value="CG723_33975"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018713">
        <property type="entry name" value="MPAB/Lcp_cat_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09995">
        <property type="entry name" value="MPAB_Lcp_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MPAB_Lcp_cat" evidence="2">
        <location>
            <begin position="1"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="265"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="271"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN07531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="289" mass="32103" checksum="8B26EEE1F7AC3C06" modified="2018-04-25" version="1">MMWVAGVRALYFQALLPRAVRGVMQNSDFRKDAWGRLMRTAGFVGTTTYGTTEAAERAGARVRKIHSHLKVTDPGTGERYGVDEPELLLWVHCAEIDSYLHVARRSGFRLTDAQADQYISEHRTSARLVGLDPADVPGDRAQLAAYFEEMRPLLAAGPEAQDVDDFLRRPPVHPLLIPARATLWRRVSHLAYASLPPYAHELYGRQAPAPTAVTRGLRFTGTVLRCVPARVRWQLPPKHILRAMSRLGPGSRPAPYKIGSRTAILDRPGRAQRGDGGDSTRCRSRGRPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JKZ8</accession>
    <name>A0A2M9JKZ8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_32800</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000019">
        <property type="protein sequence ID" value="PJN07551.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN07551">
        <property type="protein sequence ID" value="PJN07551"/>
        <property type="gene ID" value="CG723_32800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="17"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="43"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="69"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="161"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN07551.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="268" mass="27344" checksum="956C4F08EDCA0269" modified="2018-04-25" version="1">MSAPHQREARTGTDVRLLRAAVFTAVCVALSAAGHVLASCATVPLWTLGVGFLAVFAVAAPLAGRERSLPGIAAALVVGQTGLHTLFGVGQHGTMTMAQTTQEPSVVERAARLMCGSGMAAISPAQAQKILSDAGVEPGSGTGMHHHTATEAVTSMPLLPSLPMLLGHLLAAVVAGWLLRHGDLALGRLVRLSANSAHGVAQGALVRSLRAALALVRALRTGLPGAAEAAPHVVPIELLAPLPLRTTALQHSVIRRGPPVGDAFRLAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JL16</accession>
    <name>A0A2M9JL16_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_33780</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000020">
        <property type="protein sequence ID" value="PJN07467.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN07467">
        <property type="protein sequence ID" value="PJN07467"/>
        <property type="gene ID" value="CG723_33780"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013096">
        <property type="entry name" value="Cupin_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07883">
        <property type="entry name" value="Cupin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="18"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN07467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="192" mass="20897" checksum="4040594551C4A4B6" modified="2018-04-25" version="1">MSNDQSGPGFAAGIGARLRRRRRALHLTLKAVAEQAGLTEGYLSQVERDQVNASVRTLQRLCDVLKLSVGDLFEQGGSAASPVLRFRDAHGMSFGDGATKIKLTPGSFDHLEVLLGHFAPGGSTGVEPYTHGSSEEILLVLSGEVEVWVRDQHHRLRALDSVHYLSSDPHRVVEMTGVDEARVLWAMAPPTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JL28</accession>
    <name>A0A2M9JL28_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Cupin_2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_32970</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000019">
        <property type="protein sequence ID" value="PJN07580.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN07580">
        <property type="protein sequence ID" value="PJN07580"/>
        <property type="gene ID" value="CG723_32970"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013096">
        <property type="entry name" value="Cupin_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07883">
        <property type="entry name" value="Cupin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cupin_2" evidence="1">
        <location>
            <begin position="33"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN07580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="105" mass="11614" checksum="F619A298F787E352" modified="2018-04-25" version="1">MKAFRLDELEAERAANDGAYLQFLRERNMSVGLYALDAGDQDPQQPHQQDEVYLVVSGRGSITVGMETTQVARGSVVYVPAGVAHKFHHISEDLRVLVVFSPPES</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JLG2</accession>
    <name>A0A2M9JLG2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Zf-TFIIB domain containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_32070</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000018">
        <property type="protein sequence ID" value="PJN07709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN07709">
        <property type="protein sequence ID" value="PJN07709"/>
        <property type="gene ID" value="CG723_32070"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027392">
        <property type="entry name" value="TF_Znf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13453">
        <property type="entry name" value="zf-TFIIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="zf-TFIIB" evidence="2">
        <location>
            <begin position="2"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="42"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="50"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN07709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="94" mass="10273" checksum="2A83C1EF39290406" modified="2018-04-25" version="1">MQCPKCHAPMHTYNRNGVQIEQCSGCRGIFLDYGELESLTRLESQWQQQAPPAPPAPQAYPSAPAPAWGAPHHGGHHGHHGHHKGGFGRMLFSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JMH0</accession>
    <name>A0A2M9JMH0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="10">DNA alkylation response protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CG723_30795</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CB01635</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000016">
        <property type="protein sequence ID" value="PJN08071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08071">
        <property type="protein sequence ID" value="PJN08071"/>
        <property type="gene ID" value="CG723_30795"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003995">
        <property type="term" value="F:acyl-CoA dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006089">
        <property type="entry name" value="Acyl-CoA_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041504">
        <property type="entry name" value="AidB_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18158">
        <property type="entry name" value="AidB_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="SSF47203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="SSF56645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00072">
        <property type="entry name" value="ACYL_COA_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0274">FAD</keyword>
    <keyword evidence="3 5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AidB_N" evidence="9">
        <location>
            <begin position="14"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_M" evidence="8">
        <location>
            <begin position="182"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_1" evidence="7">
        <location>
            <begin position="286"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF18158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PJN08071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="546" mass="58940" checksum="D50DC22EFB0876BF" modified="2018-04-25" version="1">MPSNPTAVTHEVTNQAPPLTGHDVADDPVLLEGVRREGAEWSLDDLHRIGRRAGSEEVQRWADEANRYEPVLRTHDRYGNRIDEVDFHPSYHALMDVAVGEGLAGSAWADERPGAHVARAAAFMVWSSTEAGHGCPVSMTYAVVPALRHAPDLAKIYEPLLTSRVYEPGLHTPGEKRGLLAGMGMTEKQGGTDVRANTTSATEQADGTWRLRGHKWFTSAPMNDLFLVLAQAPGGLSCFLVPRVLPDGSRNTFRIQRLKDKLGNRSNASSEPEFDDTVAWLVGAEGKGVRTIIDMVTMTRLDCVLGSAAGTRAALAQAAHHARHRSVFGAKLIDQPLMRNVLADLAVESEAATTLALRLAGAADRAQRGDEGERAFLRLATAVGKYWVCKRQPVAVAEALECLGGNGYDETSGMPRLYRDAPLNGIWEGSGNVNALDMLRALAREPESLEAFRTEIEAAAGGDRRLDTAWQELQGELVLTEDAPLRARRVIERAALVLQGSLLVRHAPAAVADAFCASRLAGDRGLAFGTLPPGTDFAGLLERLPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JMM2</accession>
    <name>A0A2M9JMM2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Lysine transporter LysE</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CG723_30720</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000016">
        <property type="protein sequence ID" value="PJN08057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08057">
        <property type="protein sequence ID" value="PJN08057"/>
        <property type="gene ID" value="CG723_30720"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006865">
        <property type="term" value="P:amino acid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001123">
        <property type="entry name" value="LeuE-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30086">
        <property type="entry name" value="PTHR30086"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01810">
        <property type="entry name" value="LysE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="38"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="69"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="109"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="148"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="182"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PJN08057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="205" mass="21146" checksum="E77884D5C08D4816" modified="2018-04-25" version="1">MDTTTVAAFLAVDLLLVFTPGADWAYAISAGLRARSVVPAVTGLIAGYMGYTLLAVVGLVAIVASSATALTALTVAGAVYLMWLGWGVLRRPAVLGASTEPMATSRGQIILKGAGISGLNPKALLLYFSLFPQFIRPADGWPVAAQTGLLSALHMTACAVVYLAVGVLARTVLRTRPSAARTVTRASGAMMIVIGGFLLAERLAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-05-25" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JMW0</accession>
    <name>A0A2M9JMW0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Helicase SNF2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_29520</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000015">
        <property type="protein sequence ID" value="PJN08147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08147">
        <property type="protein sequence ID" value="PJN08147"/>
        <property type="gene ID" value="CG723_29520"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140658">
        <property type="term" value="F:ATP-dependent chromatin remodeler activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0347">Helicase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="1">
        <location>
            <begin position="291"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="2">
        <location>
            <begin position="535"/>
            <end position="699"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN08147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="714" mass="77326" checksum="E8765D8D6C3EB821" modified="2018-04-25" version="1">MGRRERGVVGGGVWLEGAARGVVGDHARAVEAVRGALQPIHEAEAAQALGAISVARLKDVTEGRLRLGEVERSGLSSVLQVLEAGTYRLRQIPGVGEQTANQLVAAARQISDAVRETVAVHIDVDRPEPRTTALVTALHVLVEAGPEARRAVETAAALAERLGPLLADARPAAGRLRMLLVGKAKRAQALEAVAEIRELTEEAVRAGHPELLAQASVDLLRGSSDDVAAWVDFELRSAEYYSLLAEISGRAPDTAASEGFLPDEVAERVRGQALDDTRRRVSLRGYQAFGARFALAQRKVILGDEMGLGKTIQAIAALAHLAAEGRSHFMVVCPASVLINWTREIESRSKLRVLPLHGPDRQDAYADWKGRGGVGVTTFDALRRFPVPGGGELGMLVVDEAHYVKNPQTRRSRTVAEWAERCERVLFMSGTPMENRVAEFRNLVQILRPDLADVVGDRDAVAGSKAFRKAVAPVYLRRNQQDVLTELPALQHTDEWEELSASDEEAYREAVRAGNFMAMRRAAYARPESSAKLNRLREIVEDAAENGLKVVVFSTFRDVLAVVKDALDGAALFGPISGSVPPARRQQLVDEFAAVSGHAVLLAQIEAGGVGLNMQAATVVIICEPQVKPTVEHQAVARAHRMGQVRSVQVHRLLTTGGVDERMVKLLENKSRLFDAYARRSAMAEATPDAVDVSDTSLARRIVEDEQARLAMGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JMX9</accession>
    <name>A0A2M9JMX9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_29825</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000015">
        <property type="protein sequence ID" value="PJN08205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08205">
        <property type="protein sequence ID" value="PJN08205"/>
        <property type="gene ID" value="CG723_29825"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010406">
        <property type="entry name" value="DUF1003"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41386">
        <property type="entry name" value="PTHR41386"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06210">
        <property type="entry name" value="DUF1003"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="57"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="86"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN08205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="191" mass="22095" checksum="F46D590A3ECA04E5" modified="2018-04-25" version="1">MAPAERERDGRPEAARAPRFRLDLPRPPRRKLLPDYDPEAFGRLSERIARFLGTGRFIVWMTVIIIAWVVWNVSAPGNLRFDQYPFIFLTLMLSLQASYAAPLILLAQNRQDDRDKVNLEQDRKQNERSIADTEYLSREVAALRMGLGEVATRDWIRSELQDLLKELEDQRVTFPAGSSSDASHRRDVDDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JN87</accession>
    <name>A0A2M9JN87_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">acidPPc domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_28485</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000014">
        <property type="protein sequence ID" value="PJN08329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08329">
        <property type="protein sequence ID" value="PJN08329"/>
        <property type="gene ID" value="CG723_28485"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036938">
        <property type="entry name" value="P_Acid_Pase_2/haloperoxi_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000326">
        <property type="entry name" value="P_Acid_Pase_2/haloperoxidase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01569">
        <property type="entry name" value="PAP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00014">
        <property type="entry name" value="acidPPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48317">
        <property type="entry name" value="SSF48317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="41"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="64"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="138"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="162"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="domain" description="acidPPc" evidence="2">
        <location>
            <begin position="63"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN08329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="202" mass="21162" checksum="FA9B83621567E1A2" modified="2018-04-25" version="1">MSAPLAFSGASVDGGLYTWVTELAHSTPHAVNAVVSAWSDYGLALFAVLMIAAWWRARGEGGVLMARVLASPVIVVVAYAANSVFKSVVDEQRPCRTLHTVTVEVCPALGDWSFPSNHAVIAAAAAVTLLLADRRIGLIAVPAAVLMGASRVWIGAHYPHDVAVGLAIGATLALLLTPLATRAVPLVDRLSTTRLRPLVSTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JN88</accession>
    <name>A0A2M9JN88_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">CopY family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_28495</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the BlaI transcriptional regulatory family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000014">
        <property type="protein sequence ID" value="PJN08331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08331">
        <property type="protein sequence ID" value="PJN08331"/>
        <property type="gene ID" value="CG723_28495"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005650">
        <property type="entry name" value="BlaI_family"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34134">
        <property type="entry name" value="PTHR34134"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03965">
        <property type="entry name" value="Penicillinase_R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="116"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN08331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="141" mass="14916" checksum="A2801D1B83706579" modified="2018-04-25" version="1">MAEEQERRPAGELEASVLAALWAAETPLTPGEVQRALADGLARTTVTTILTRLYGKGTVTRDRAGRGYAYRPAQDAHGLTARRMHAELDKDEDRGTVLARFVSALSSEDEQMLRALLDGDGGSDSGTEGGTGRGDTGGTGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JNN7</accession>
    <name>A0A2M9JNN7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CG723_28220</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000014">
        <property type="protein sequence ID" value="PJN08480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08480">
        <property type="protein sequence ID" value="PJN08480"/>
        <property type="gene ID" value="CG723_28220"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PJN08480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="70" mass="7286" checksum="D438968C1BD6B59F" modified="2018-04-25" version="1">MPLTHSPFGPFKIGPEGGVALCPPSVTSSTGGGEYAAAAVGEPRFGRGRRRYGLGNRLECAGGLPHYRSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-05-25" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JNT9</accession>
    <name>A0A2M9JNT9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_27515</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000013">
        <property type="protein sequence ID" value="PJN08530.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08530">
        <property type="protein sequence ID" value="PJN08530"/>
        <property type="gene ID" value="CG723_27515"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046102">
        <property type="entry name" value="DUF6039"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19505">
        <property type="entry name" value="DUF6039"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="146"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="146"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN08530.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="305" mass="34225" checksum="5CE47FEBEAF52A5C" modified="2018-04-25" version="1">MTDAASQAQGAFLPAHSGPLGSGSDLLHSGNAGFIIHRAGQLNHAFRAQGRQFATDLVGHLNKVVEGVATIVVHEEILGTADRLHWLIHMKQPNDYSRFLEIADHDRSFKEITEADRIAAAEGAGNWERMFVEGSFQERVYVPQHGLDEHDDDHDHHDEPSDTFVPPARHQTGLPDSRMRSSVDSGLTIIRTAQTAFRFRTEAREFAFAWASEVNRALGGELTVYLYEETFGQQDRIHWMIHLDSLDTYRKLTELSRHDADYQALFGRQFVPDFKGGGGWEQTFVSPTIQDTVLTPLHPGAPAWF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JPK6</accession>
    <name>A0A2M9JPK6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Serine/threonine protein kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CG723_26830</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000012">
        <property type="protein sequence ID" value="PJN08808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08808">
        <property type="protein sequence ID" value="PJN08808"/>
        <property type="gene ID" value="CG723_26830"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031636">
        <property type="entry name" value="PknG_TPR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16918">
        <property type="entry name" value="PknG_TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="3">
        <location>
            <begin position="54"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="371"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="23"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="84"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PJN08808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="748" mass="81401" checksum="CEE2F08B21B8A7DE" modified="2018-04-25" version="1">MPPPDGPRDAWVTLPDEGPDPTALPEVRPRDDRGRAEGPGESALEQGELLAGQYQVVRRLGRGGMGDVYLALDKKVDDREVAVKTLRPEQLASRLGSLEDERQAFADLHHDGIIPVFNYGRHARVGPFLVLPYVDGLNLDEIRALARHDPDRFGGARFHEFVLAYGLRVLSALDHLHARPAPRKVYGDLKPQNVMHDGATTKVIDVGSIREEGASGLTTDGFRAPNVPLAPPALNGASAPRDDLFSLGETLRTLSGLGIGPHSLAELGALDRMHDGDPMTAQAVALTTTPAPEGLGLVSLARALRRATRPEPADRYADAAEMADQLRGVFRELRSLRTGQETFEPSPLFMQSPYALDGALGVAPVLPRWATPAGGTPPTPLHEPPSAADVAGRLPVPRPDPHDAHHDGLSRLADADPAALLQHTGDWRDSPEVRLLRCRLRLRVAVRAERAEGERPDLEAAAEELRGAVDGIGRELSRHDWRIDWHRGLLDLANDDVASARDYFDQVYGAIPGEYAPKLALGHCAERLGHWHEALTFYEAVRLRNPSLGSAAFGAARAGLALGGATPDTYAIEALDAVPQHSRHRTGARTATVRIAVEYATTANGLRTALTRLARLFNEHGLTDEQARVRMKAEVWEAAQRLVADGKVGKEALARLSEAADRRDGDARDSGGRLEFPSTEATLRRQLSQFYRALARQAARSGSPHGEAVAERLLDRAYLVRPLALSHRRDGTWPTRLRLTGRRPAADR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JPR5</accession>
    <name>A0A2M9JPR5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_27310</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000012">
        <property type="protein sequence ID" value="PJN08787.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08787">
        <property type="protein sequence ID" value="PJN08787"/>
        <property type="gene ID" value="CG723_27310"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014961457" evidence="2">
        <location>
            <begin position="30"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="104"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="130"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN08787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="151" mass="15756" checksum="E4DF99C6709FA509" modified="2018-04-25" version="1">MLSYTRRAAMAVVALLILTAGVRASWASAQHVMLTKGRERGTMTVTRCTDGTCAGPYAPLSPGSQPRARVVIDRSIAEKKGARIPVVVKPGSDEVVRSGAAGFFHAWVPLGGALLLAAVVIAGGLRLTRWAWVTAATGVALLSAAFATLTW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JPY4</accession>
    <name>A0A2M9JPY4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MarR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_25455</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000011">
        <property type="protein sequence ID" value="PJN08847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08847">
        <property type="protein sequence ID" value="PJN08847"/>
        <property type="gene ID" value="CG723_25455"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000835">
        <property type="entry name" value="HTH_MarR-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023187">
        <property type="entry name" value="Tscrpt_reg_MarR-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01047">
        <property type="entry name" value="MarR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00347">
        <property type="entry name" value="HTH_MARR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01117">
        <property type="entry name" value="HTH_MARR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50995">
        <property type="entry name" value="HTH_MARR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH marR-type" evidence="1">
        <location>
            <begin position="28"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN08847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="169" mass="18475" checksum="35BA7EC295E4A386" modified="2018-04-25" version="1">MPKPLSLAFDPIARADELWKQRWGSVPSMGAITSIMRAHQILLAEVDAVVKPYGLTFARYEALVLLTFSKAGELPMSKIGERLMVHPTSVTNTVDRLVRSGLVDKRPNPNDGRGTLASITAKGREVCDAATRDLMAMDFGLGAYDAEECGEIFAMLRPLRVAAHDFDEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JQ22</accession>
    <name>A0A2M9JQ22_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">YCII domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_26090</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the YciI family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000011">
        <property type="protein sequence ID" value="PJN08956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08956">
        <property type="protein sequence ID" value="PJN08956"/>
        <property type="gene ID" value="CG723_26090"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005545">
        <property type="entry name" value="YCII"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03795">
        <property type="entry name" value="YCII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YCII" evidence="2">
        <location>
            <begin position="1"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007689"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN08956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="137" mass="14698" checksum="853F916DBB46512D" modified="2018-04-25" version="1">MKYLMMVTGTQLDYEAMAGKASEGNPAWGEKDIQTMFAHMQKINDDLAESGEMLAGEGLAEPAKARFVTPDAQGRPVITDGPYGETKELLAGFWILECENLDRVTEIAKRVAECPAPAGAPVRPVVIRAIMGSGGDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JQI7</accession>
    <name>A0A2M9JQI7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA primase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_24775</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000010">
        <property type="protein sequence ID" value="PJN09131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN09131">
        <property type="protein sequence ID" value="PJN09131"/>
        <property type="gene ID" value="CG723_24775"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015330">
        <property type="entry name" value="DNA_primase/pol_bifunc_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09250">
        <property type="entry name" value="Prim-Pol"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00943">
        <property type="entry name" value="Prim-Pol"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Prim-Pol" evidence="1">
        <location>
            <begin position="8"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN09131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="280" mass="29583" checksum="5F5DA252A570C824" modified="2018-04-25" version="1">MSEHMHTALRLAAHGVPVLPLRAGKVPFGNCPACAKNACGGRPNMKTPGSCTCPNPCHGWAAATTVHPIVNSMPWARAWREAAGVAYHPGGAGLTVVDLDNAEAITWARACLPATRIVPTTRGEHWLYRGAMQGANAVRPGVDIKSTMAYARWLGPGTGPMAPLPDVVRALTVKEPTPARPASVTVLAPASGGECPHRTPTYLDRGIAMAEQRITEAREAVHATVYRTFLAVLSTHGRCGCLTETHTARLFTAAQAKGESPRHCTDAWTNALTTLGLSHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JQL4</accession>
    <name>A0A2M9JQL4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Trehalose-6-phosphate synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_24950</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyltransferase 20 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000010">
        <property type="protein sequence ID" value="PJN09161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN09161">
        <property type="protein sequence ID" value="PJN09161"/>
        <property type="gene ID" value="CG723_24950"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005992">
        <property type="term" value="P:trehalose biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03788">
        <property type="entry name" value="GT20_TPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001830">
        <property type="entry name" value="Glyco_trans_20"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10788">
        <property type="entry name" value="PTHR10788"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00982">
        <property type="entry name" value="Glyco_transf_20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008799"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN09161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="468" mass="50958" checksum="C67A21EC5035FC43" modified="2018-04-25" version="1">MASTQGAQILVASNRGPVSYELGADGTLDARRGGGGLVSGLSAIGQDPDGASAVWVCAALGAGDREAVRRGVGEPGVRMLDIDPEVYADAYNGIANSVLWFVHHMLYQTPLEPVFGPEFRARWASYEAYNRAFAEALAAEAGPGAAVLVQDYHLALVPGMLRELRDDLRIGHFSHTPWAPVDYFRMLPDDIAGQLLRGMLGADRLGFLTRRWADTFTACCEAVVGGTFGTEIGVHGLGADADFLRERSRRPDVEERLAALREQIGDPDRKVIVRVDRTELSKNIVRGLRAYRLLLEEHPEWRERVVHVAFAYPSRQDLTVYREYTDEVSRVAEEINSHFGTESWTPVVLHVKDDFARSLAAYRLADVALVNPIRDGMNLVAKEVPVVSDEGCALVLSREAGAYEELGEDALVVNPYDVSATAEALHAALVMGSGERGERAKRLAAAATALPPAQWFLDQLNALRGLGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JQQ1</accession>
    <name>A0A2M9JQQ1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Iron-siderophore ABC transporter substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_25115</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000010">
        <property type="protein sequence ID" value="PJN09192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN09192">
        <property type="protein sequence ID" value="PJN09192"/>
        <property type="gene ID" value="CG723_25115"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002491">
        <property type="entry name" value="ABC_transptr_periplasmic_BD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01497">
        <property type="entry name" value="Peripla_BP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50983">
        <property type="entry name" value="FE_B12_PBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015006590" evidence="1">
        <location>
            <begin position="31"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="domain" description="Fe/B12 periplasmic-binding" evidence="2">
        <location>
            <begin position="62"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN09192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="325" mass="34034" checksum="B5D20C99A9BF27AC" modified="2018-04-25" version="1">MTRSDHRALTAGALVLTGALALTACGSSDGDSGSDAAAAASPKTHTVSTAMGDVKVPEHPTRVVVLDTGELDSALTLGVKPVGATHAATEAGFPSYLPGDEVKGIKEVGEIANPNMEAVAALKPDLILTSKVRDGARYKQLSAIAPTVMTESTGTAWKENFQVHADALGRKAAAKKVIADYDAHVAKVTTAIGGKEKAAATDINFVRFVEGADIRIYGKQNYIGSILADLGVGRPAITDKAKDGFSYDVSPEKIDLADADVIFTSTYGDPSKAKATETMKSGLWKNLRASEDGKVFKVDDNLWIAGIGYTAAHQILDEFQKDLTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JR73</accession>
    <name>A0A2M9JR73_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Peptide ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CG723_23910</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CB01635</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000009">
        <property type="protein sequence ID" value="PJN09375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN09375">
        <property type="protein sequence ID" value="PJN09375"/>
        <property type="gene ID" value="CG723_23910"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="101"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="141"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="191"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="248"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="295"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="102"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PJN09375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="331" mass="35945" checksum="4513960CB528A967" modified="2018-04-25" version="1">MTYFIRRAGFFLATLWAAVTLNFLIPRLQPGDPAQALLARLAGKTGVIAPDQLAAVRKMLGAPDGSLFTQYWDYLGALAHGQFGISYTYYPYSVGDVIAQAVPWTLILVGVTQILSFIVGTLLGAWAAYRRNSRVDTVITLGSTFVGTLPFFWIALLLVFVFAITLNWFPEGGGYGGGSSPSWTWVFFSDAFQHSVLPAVALLITGPIGWIIGMRNNMVQTLGEDYARLARAKGLPRRRIALTYGARIAILPNVTGFAIALGGILGGTVLVESIFSYPGLGRLLLESVSNKDFPLMQALFLFTTVGVLIANFLADMAYGFLDPRVRRTEAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JS23</accession>
    <name>A0A2M9JS23_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Lyase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CG723_20925</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CB01635</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the polysaccharide lyase 8 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000007">
        <property type="protein sequence ID" value="PJN09676.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN09676">
        <property type="protein sequence ID" value="PJN09676"/>
        <property type="gene ID" value="CG723_20925"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.220.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008929">
        <property type="entry name" value="Chondroitin_lyas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014718">
        <property type="entry name" value="GH-type_carb-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038970">
        <property type="entry name" value="Lyase_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011071">
        <property type="entry name" value="Lyase_8-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012970">
        <property type="entry name" value="Lyase_8_alpha_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004103">
        <property type="entry name" value="Lyase_8_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003159">
        <property type="entry name" value="Lyase_8_central_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38481">
        <property type="entry name" value="PTHR38481"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02278">
        <property type="entry name" value="Lyase_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02884">
        <property type="entry name" value="Lyase_8_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08124">
        <property type="entry name" value="Lyase_8_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48230">
        <property type="entry name" value="SSF48230"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49863">
        <property type="entry name" value="SSF49863"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="SSF74650"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0456">Lyase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014902910" evidence="2">
        <location>
            <begin position="27"/>
            <end position="783"/>
        </location>
    </feature>
    <feature type="domain" description="Lyase_8_N" evidence="5">
        <location>
            <begin position="44"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="domain" description="Lyase_8" evidence="3">
        <location>
            <begin position="408"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="domain" description="Lyase_8_C" evidence="4">
        <location>
            <begin position="674"/>
            <end position="736"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF08124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PJN09676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="783" mass="84314" checksum="94FC027C83C8B72A" modified="2018-04-25" version="1">MTPTRRTFLIASTLLAGAALAPPAHAAGASDAADDEFDGLRKRWLEISLGTGYDATAEPYASRLKELGELARGFRATMAPTATSLWPGYPFDPPAGITQGYNRLWTMTQAYAQEGTGSTGDAGLLADIVKGLDHLAATVYNATTTRYGNWWEWQIGSPRLLMDIVAVLYDHLTQDRRDAAFAAVDHFIPDAVLRDYSGTSTGANRVDLCRSVALRGVLGRNADKTALARDALSPVFPYVTKGDGLYADGSFIQHTYIAYSGTYGQVMLDGLGRLFTLLAGSTWAVTDPNRQIILDSVEHAYAPLLFDGLMMDSVNGRAISRGYLNSDDLKVMRSDHFHGQGLIAAMAQLAAGASAAERERWHGRIKGWIERDTVTPLLTARQFGVADLSRLHAVADSAVAAAPEPVGHQLFAAMDRAVHKRPGFAANISMSSDRIAYYECGNGENPRGWHTGAGMLSWWASGKRSGRSDQYTDWFWPTVDFYRLPGTTVSTKRLADKAGGEWGAARPDVKWVGGATDGEFAAVGQHVKGLGSTLQARKSWFCLADTVVCLGAGITAADGVPVETVVDNRNLGEGGTQAFTVDGGARARWAHLEGHGGWVFPGGAPLRHLREDRTGAWSDINTTSSTERRTRRWQTLWLDHGTDPTDAAYAYLLMPGASKDNLARRAGDRHWLSVLANTAAAQAITVPSLGVSAANFWAAGSVGELTVSAPASVLLRRKGRTATLSISEPPRTGEPVDITWDRPVRRVVSHDPSVEVVATGRRLRLRVTPGAACVSHRCEVALS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JS84</accession>
    <name>A0A2M9JS84_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Phosphotriesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_21235</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
        <text evidence="1">Binds 2 divalent metal cations per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the metallo-dependent hydrolases superfamily. Phosphotriesterase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000007">
        <property type="protein sequence ID" value="PJN09729.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN09729">
        <property type="protein sequence ID" value="PJN09729"/>
        <property type="gene ID" value="CG723_21235"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009056">
        <property type="term" value="P:catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001559">
        <property type="entry name" value="Phosphotriesterase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10819">
        <property type="entry name" value="PTHR10819"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02126">
        <property type="entry name" value="PTE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016839">
        <property type="entry name" value="PhP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51347">
        <property type="entry name" value="PHOSPHOTRIESTERASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="1">
        <location>
            <position position="26"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="28"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="142"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="175"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="203"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="260"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR601559-52"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN09729.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="316" mass="33314" checksum="F58C2ECF4AAC5A74" modified="2018-04-25" version="1">MHTPPLIHTVTGPLPATAVRGPALAHEHLVLDLDRHGNGGAVLDAEAHGPAVTAELAALREEFGLSLVIELTCRGMGRDPRALARISRDAQVAVVAATGWYYEPFHTPELAGAEVGQLADTLVREIDGGLGASGIRPGVLGEVGSHGDVPSEPESRALRAAARAAVATGLSVATHAQLGRGGLAQLELLTGEGLAPHRISVGHQDLLDDPAVHKELAASGAYVAFDTVGKESYQSDDIRLRLLLALLEAGYADRVLLSCDISRHAYLEREGGQGYGHLFRSFLPRARAAGVDDGLMDLMTRRNPLRFLTGASVEEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JSG5</accession>
    <name>A0A2M9JSG5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CG723_21695</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CB01635</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000007">
        <property type="protein sequence ID" value="PJN09810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN09810">
        <property type="protein sequence ID" value="PJN09810"/>
        <property type="gene ID" value="CG723_21695"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045621">
        <property type="entry name" value="BPD_transp_1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19300">
        <property type="entry name" value="BPD_transp_1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="45"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="131"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="174"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="216"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="282"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="326"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="7">
        <location>
            <begin position="132"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PJN09810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="358" mass="38542" checksum="917E67D17838967A" modified="2018-04-25" version="1">MTAESTPALVQSADTDGPAQAGPSAARGPRARNTKAYLQYVAGKIAGAIVSLFAVLVTSFFLFRLIPSDPVKQMTGGRRVSAQQLESLRHQFGLDLPMWQQFTNYIGDALTGDFGTSYQFHTPVIDKITEALPATLLLTGTAYVLYTALGIWLGTRTAWRNGSRSDRFNTAFALTLYSIPSFWLGLLLIIVFSVGLGPIPGLFPTGGLESGGESGFAYVLDVAHHLVLPVVTLVAVGYAQTLLVMRSSLLDEMGSDYLTTARAKGLRDDVVRRKHAVPNAMLPTFTLMFVNLGHVVAGQILVETVFSWPGLGGLFYSALSVPDLPLVQGLFFVFATAVILANTLADVLYPLLDPRVGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JTB8</accession>
    <name>A0A2M9JTB8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cupin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_20380</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000006">
        <property type="protein sequence ID" value="PJN10072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN10072">
        <property type="protein sequence ID" value="PJN10072"/>
        <property type="gene ID" value="CG723_20380"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013096">
        <property type="entry name" value="Cupin_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07883">
        <property type="entry name" value="Cupin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cupin_2" evidence="1">
        <location>
            <begin position="57"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN10072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="135" mass="14939" checksum="F57C10BBC9DE81B6" modified="2018-04-25" version="1">MKTTPITTPIDLFASALQFRPDGAVRAAERQMASSDSGAWQVVTFHVETDADVHADHWEMHPEAEEAVCCLTGGVRLYFRAATPGGAEDMVRLQAGTAVIVPRGRWHRLELNAPSDLMSITLRRGTRLEKRTDTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-06-02" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JTM1</accession>
    <name>A0A2M9JTM1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">DNA-binding response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CG723_17640</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000005">
        <property type="protein sequence ID" value="PJN10219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN10219">
        <property type="protein sequence ID" value="PJN10219"/>
        <property type="gene ID" value="CG723_17640"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00383">
        <property type="entry name" value="trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="3"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="domain" description="OmpR/PhoB-type" evidence="5">
        <location>
            <begin position="126"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="3">
        <location>
            <begin position="126"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PJN10219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="225" mass="24511" checksum="66BB68205FC80382" modified="2018-04-25" version="1">MTKILVVDDEPEVRAAVEDGLTVEGYEVRGARDGLEALSAVSSWQPDALVLDVMMPVLDGLGVCRQLRAMGDRTPVLVLTALDSVSERVDGLDAGADDYLVKPFALDELVARVRALLRRAAPTPTEGGLAYADLVLDPDTRTGRRGGRPLEFSRTESALLELLMRHPGQVLPRELILELVWGRDFGPDSNSLAVYVGYLRRKLEAGGETRLVHTVHGIGYRLDVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JTM7</accession>
    <name>A0A2M9JTM7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CG723_17825</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000005">
        <property type="protein sequence ID" value="PJN10251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN10251">
        <property type="protein sequence ID" value="PJN10251"/>
        <property type="gene ID" value="CG723_17825"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005079">
        <property type="entry name" value="Peptidase_C45"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03417">
        <property type="entry name" value="AAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PJN10251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="373" mass="39458" checksum="BA05EDDFA1C077AF" modified="2018-04-25" version="1">MIARPAERLHVAVASSDPFARGAARGERLRDTLPGGIAGYDRFFRLGGIGPQQVRDDAERALAIIDAFRPRARAEIEGIAHGAGVDVWHIAALNARTEILARSATVPPGECSTIVRRTGGAAGTVDTFGIQTWDWHVELTPYWHTLESRGGTHDVVGLTEHGILGKIGINSAGLALHFNILGHRRDGVGGVPMHVLASVVLEEAGSVAEAVEIVRGAPIASSGSFALFDTTEAVLLDLSPEGVFAVETDQGTLVRTNHFLSPAPAAGEKTWLYQPDSGERYDLIRKRLTPTALPQSPDELVALLVSGEGEAALTCLPDMSLPEGQRWAGLATVVLEPATSTARILDGTPADAASRPWRHLAARRGSDAGSGTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JTT5</accession>
    <name>A0A2M9JTT5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Amino acid transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CG723_17970</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CB01635</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000005">
        <property type="protein sequence ID" value="PJN10279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN10279">
        <property type="protein sequence ID" value="PJN10279"/>
        <property type="gene ID" value="CG723_17970"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="32"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="63"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="103"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="146"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="176"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="218"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="257"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="316"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="366"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="397"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="431"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="476"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PJN10279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="527" mass="55848" checksum="07DF9FA7A4AD9234" modified="2018-04-25" version="1">MATSPDTTSDAAPDSSQEKGLRTGALGMTTSLILSVASAAPAYSLAATLAFIVAFVGFQAPSIVVLAFVPILFVSFGYAALNRQEPDCGTIFTWATRVLGPRVGFMGGWAIITSFTLVMASLAQVAGQYVFILFGAKGIGSDPSSPWVLLAGLGWIALMTAVCYRGIEVAAAVQRALLFLEFAMLAVFSVVALVRVYTGNAGAGARHPHWSWLNPFEISSPSAFVSGLVLMLFIYWGWETALTVNEETTDRHRTPGVAAVSSTVMLLVLYLVSTVATLAFAGTGTTGTGLGNPDNFGDVFSAIGKAVFGDSGFGSFLWHLLVLMVLSSAAASTETTVLSLGRTLLAMGGRGAAPRVFAKVHPRYSIPQFSTIATGVAGAVCYVVMNFLSHGQVIGDAVSSCGLMIAFYYGLTGLTSAWAHRTQWRRSAADFWLRLTLPAIGGLTLVAAGLWSLKNDWDPVNSYTSWTLPFAPHRRVGGVFIIGVGTLLLGYLLMLAYGRISPRFFTGAPKETAAVAEHRPPHERISR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JTX4</accession>
    <name>A0A2M9JTX4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Portal protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CG723_17750</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000005">
        <property type="protein sequence ID" value="PJN10237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN10237">
        <property type="protein sequence ID" value="PJN10237"/>
        <property type="gene ID" value="CG723_17750"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006813">
        <property type="term" value="P:potassium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003148">
        <property type="entry name" value="RCK_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02254">
        <property type="entry name" value="TrkA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51201">
        <property type="entry name" value="RCK_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="190"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="243"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="domain" description="RCK N-terminal" evidence="3">
        <location>
            <begin position="289"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="451"/>
            <end position="477"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PJN10237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="477" mass="50515" checksum="54B33638AE930E40" modified="2018-04-25" version="1">MNPQTFQDQAPPHIPASGQRIVIIEDDEALGRSAAAHIGRWYGTVQRLPRPDDDTLREHLEQSVDAVAVVSRDDIVALRYALLAEHLKPGIRLVVTLFDRTVADEVSRTVPNCTVLSMTDAIVPSLLAECLAPSYAMLQPDGGGVIAVRREDGTTSVEHLNGRALAAHAHVHPRASFPAWLRSLGTSAKALIASLAALSVAFSVDIALGVLVLHEHWTDSVWNAARALTTIGSSPAAEHGPGWYKVLSAVSMLAVLVLAAIFTASVVDRFTGHRMTSILGARSIPRRGHVIVVGLGQVGLRLSARLKDLGIKVVAVERNPQAACLPLARSLNIPVVLGRGGDRFLLERLSVLRARGLAAVGSDSLANMAVAVAARAVAPDQRIILRAGSDEVTTDSQSLFRIGAVCDFPRIVGAFVAASVLGAEPSSVFVAEDRTCALFPDGQVVDLATWDTRPEPSEDETAPGRTAPDVEASAATN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JU65</accession>
    <name>A0A2M9JU65_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CG723_18270</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CB01635</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000005">
        <property type="protein sequence ID" value="PJN10327.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN10327">
        <property type="protein sequence ID" value="PJN10327"/>
        <property type="gene ID" value="CG723_18270"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001851">
        <property type="entry name" value="ABC_transp_permease"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02653">
        <property type="entry name" value="BPD_transp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="23"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="49"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="77"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="102"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="128"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="166"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="215"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="296"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PJN10327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="320" mass="32598" checksum="A8F69DB1AE4A14CF" modified="2018-04-25" version="1">MAEAAIRPAALDRARVLQWMQTYGVYAGVAVLVVVNIAVTPHFLSAENFRTQAVQVAPVIIVALGMALAIGTEGIDLSVGAVMALAASVTALYLGYGLVPALLTVAVFAAVVGLANGALVAWVGVQPIVATLALMVGGRGIALVLLPQLKDLHNPGLASLGSGDVLGIPYLIIIAAALALLVAFVIRRTTFGRQLLAIGDNRAAAKLAGLPVRRVLMLVYVACALLAAVAGVLATARLQASDPTSLGNLMELSAITAVVVGGTPLSGGRVNIAGTVAGAVLIQLLTATLIKHDLPPSWTQIAQAIVIVLAVYAARGRGKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-09-29" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JUE7</accession>
    <name>A0A2M9JUE7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_18220</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000005">
        <property type="protein sequence ID" value="PJN10493.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN10493">
        <property type="protein sequence ID" value="PJN10493"/>
        <property type="gene ID" value="CG723_18220"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="48"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="76"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="136"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="163"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="208"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="241"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="275"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="298"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="339"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="369"/>
            <end position="388"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN10493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="411" mass="42473" checksum="00162173371EEF6E" modified="2018-04-25" version="1">MPQLMPEAGPQRVIAASNFVNTVGSGLYLTAGVLYFTQDVRLPATQVGLGLGVAGFASLVTGIAAGHLADRRGARGVYAATIVVQALATAGFALVDSFWPFVLAVCAATGAQAAGRAARSPLIRYFGGDRPQEYRAYLRAVTNIGISLGALLAGWALQVGTHTAYQLLVIGNAIAFGASAAILLFLPPVAPEPAAAGPRWIALRDRPYLLLTALDGIMAIQFKVLTVAIPLWLVVATSAPHWLISGTMLVNTVIVIALQVRASRTVSSPAAGGGAYRRAGVVFLVSCSLISLSAGDPAWAAAALLLVAVVVHAVGELWHSAAGFEVSFALAPERATGQYLGVFGLGAGLADALGPSLLIALCITWGRPGWYVVGALFTVTGLAAPFVVRWAQRPVPARDLPLEAGRPVSQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JUK0</accession>
    <name>A0A2M9JUK0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CG723_18535</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000005">
        <property type="protein sequence ID" value="PJN10502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN10502">
        <property type="protein sequence ID" value="PJN10502"/>
        <property type="gene ID" value="CG723_18535"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PJN10502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="255" mass="27297" checksum="600B843A461AABF5" modified="2018-04-25" version="1">MLDDLSAADAAARVRDALEGVFDAVGATAADIESVLSSVAAEGRRPATDDLTALRPGLHTRLDRYDLVSGIGFVAAPGLLDDVPAWLEWWQRTADGSVQRLLLDLDPQRSAYSDYTHWDWFTLPRDTGQRAVAGPYVDYLCSDEYSLTLSAPVTVGGHFMGVAAADVYLRRFESVVVPLLQRLPGPARLVNARGRVAASTDPRHLVGSLTKGPDLAAVLAGPAQGTDHDELRLLPCDGVPLILATTPPMSGTRRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JUN0</accession>
    <name>A0A2M9JUN0_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF2017 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_15335</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000004">
        <property type="protein sequence ID" value="PJN10590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN10590">
        <property type="protein sequence ID" value="PJN10590"/>
        <property type="gene ID" value="CG723_15335"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018561">
        <property type="entry name" value="DUF2017"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09438">
        <property type="entry name" value="DUF2017"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF2017" evidence="2">
        <location>
            <begin position="10"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="43"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN10590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="201" mass="21595" checksum="2C28E91ADDE1E38A" modified="2018-04-25" version="1">MPGHFEPIPGGGAAVALDEVEISIIRSLAVQLLELIGPGPGGDASGDPLAELFAEGPSEPPSDPVLQRLFPDAYGGPGGEEATVDKADEQRAHSAEFRRFTENDLRAGKREDALAVVRSLDALASPGEGGAVLKLSPEESVRWMRALNDLRLAIGTRLDITDEEDSDLLYRLPDEDPRKPMVMAYLWLGGLQETLVETLMP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JV19</accession>
    <name>A0A2M9JV19_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_16215</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000004">
        <property type="protein sequence ID" value="PJN10735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN10735">
        <property type="protein sequence ID" value="PJN10735"/>
        <property type="gene ID" value="CG723_16215"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="48"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="89"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN10735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="194" mass="21906" checksum="75854C7C9B47EF17" modified="2018-04-25" version="1">MNHAQLTALGRALRLLGEHGEGLSTDTPDSKLHEMRADVKRALDLVEDSVTGDAPTTRCPEHPTGPVDENAQDLCLLCETRRRVARRSEINGAYPARPRQGEAADAPSMSRYGIREDRPQPQQRWLPEKWNGQVWQLCGTPRHDRREAEHFLAAQRREPRAASAYRLVHAFTDYEVVRVWGTPIKVDIEPMGGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-05-25" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JV40</accession>
    <name>A0A2M9JV40_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">LacI family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CG723_16210</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000004">
        <property type="protein sequence ID" value="PJN10734.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN10734">
        <property type="protein sequence ID" value="PJN10734"/>
        <property type="gene ID" value="CG723_16210"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01392">
        <property type="entry name" value="HTH_LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000843">
        <property type="entry name" value="HTH_LacI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046335">
        <property type="entry name" value="LacI/GalR-like_sensor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00356">
        <property type="entry name" value="LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13377">
        <property type="entry name" value="Peripla_BP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00036">
        <property type="entry name" value="HTHLACI"/>
    </dbReference>
    <dbReference type="SMART" id="SM00354">
        <property type="entry name" value="HTH_LACI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50932">
        <property type="entry name" value="HTH_LACI_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH lacI-type" evidence="5">
        <location>
            <begin position="2"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="327"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="343"/>
            <end position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PJN10734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="357" mass="37773" checksum="9A94A6CC7DF69BF6" modified="2018-04-25" version="1">MASIKDVAAAAGVSVATVSRVLNSHPSVSPDARARVLGAVESLGYRPNAVARSLRTAQTRTLGLVISDVLNPYFTELARSVEEEARSLGYSVIIGNADEQPDIQDHHVRTLVDRRIDGLLVSPTDGGSPLMLEAARSGTPMVFVDRWIPGVDVPVVRSDGRTAVRDLVAHLHALGHRRLAIIAGPAATTTGSERVEAFREALAAFGIALPDAYIGQGDFQADSGRRATERFLALSEPPEVVFAADNLMALGALDAIRAAGLRVPHDIGLAAFDDIPWFVHTDPPVTAIAQPTKDLGRAAVRALIDRIEGRPPQSVTLPARLVVRRSCGEAGTSEARTPAPTAPADTPTATTSTRRNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JVD2</accession>
    <name>A0A2M9JVD2_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Glutamate 5-kinase</fullName>
            <ecNumber evidence="8">2.7.2.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Gamma-glutamyl kinase</fullName>
            <shortName evidence="8">GK</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">proB</name>
        <name evidence="10" type="ORF">CG723_16890</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CB01635</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>ATP + L-glutamate = ADP + L-glutamyl 5-phosphate</text>
            <dbReference type="Rhea" id="RHEA:14877"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58274"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.2.11"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="8">Amino-acid biosynthesis; L-proline biosynthesis; L-glutamate 5-semialdehyde from L-glutamate: step 1/2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the glutamate 5-kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.2.11" evidence="8"/>
    <dbReference type="EMBL" id="NNBL01000004">
        <property type="protein sequence ID" value="PJN10846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN10846">
        <property type="protein sequence ID" value="PJN10846"/>
        <property type="gene ID" value="CG723_16890"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00098">
        <property type="reaction ID" value="UER00359"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004349">
        <property type="term" value="F:glutamate 5-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055129">
        <property type="term" value="P:L-proline biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04242">
        <property type="entry name" value="AAK_G5K_ProB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1160.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00456">
        <property type="entry name" value="ProB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036393">
        <property type="entry name" value="AceGlu_kinase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001048">
        <property type="entry name" value="Asp/Glu/Uridylate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041739">
        <property type="entry name" value="G5K_ProB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001057">
        <property type="entry name" value="Glu/AcGlu_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011529">
        <property type="entry name" value="Glu_5kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005715">
        <property type="entry name" value="Glu_5kinase/COase_Synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019797">
        <property type="entry name" value="Glutamate_5-kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002478">
        <property type="entry name" value="PUA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036974">
        <property type="entry name" value="PUA_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00696">
        <property type="entry name" value="AA_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01472">
        <property type="entry name" value="PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000729">
        <property type="entry name" value="GK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00474">
        <property type="entry name" value="GLU5KINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00359">
        <property type="entry name" value="PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53633">
        <property type="entry name" value="SSF53633"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="SSF88697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01027">
        <property type="entry name" value="proB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00902">
        <property type="entry name" value="GLUTAMATE_5_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 8" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="7 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 8 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3 8" id="KW-0641">Proline biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PUA" evidence="9">
        <location>
            <begin position="275"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="10"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="51"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="138"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="150"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="170"/>
            <end position="171"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="212"/>
            <end position="218"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022650"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PJN10846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="368" mass="38377" checksum="B35AEF782C503AA7" modified="2018-04-25" version="1">MAEARRIVVKVGSSSLTTAEGGLDADRVDALVDVLAKSRSGGEKEIVLVSSGAIAAGLAPLGLRRRPKDLARQQAAASVGQGLLVARYTASFARYGVRVGQVLLTSDDMARRAHHRNASRTLDQLLAMGALPVVNENDTVATDEIRFGDNDRLAALVAHLVHADLLVLLSDVDGLYDGDPAKPGSSRISEVRGPADIAHVKIGSAGKAGVGTGGMVTKVEAAGIAAAAGIPVVLTSAVHAADALAARDTGTYFHRTGRRSADRLLWLQHASTPQGALTLDDGAVKAVVEGRKSLLPAGIAAVEGEFGAGDPVELRDAKGRAIARGLVNFDAKEIPQLIGRSTRELARELGPAYEREVVHRDDLVLLHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JVQ9</accession>
    <name>A0A2M9JVQ9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="10">ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CG723_16315</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000004">
        <property type="protein sequence ID" value="PJN10944.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN10944">
        <property type="protein sequence ID" value="PJN10944"/>
        <property type="gene ID" value="CG723_16315"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025662">
        <property type="entry name" value="Sigma_54_int_dom_ATP-bd_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221">
        <property type="entry name" value="PTHR24221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="SSF90123"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00675">
        <property type="entry name" value="SIGMA54_INTERACT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="25"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="68"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="137"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="166"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="9">
        <location>
            <begin position="27"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="8">
        <location>
            <begin position="343"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="377"/>
            <end position="384"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PJN10944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="578" mass="62442" checksum="78FC25D78E949378" modified="2018-04-25" version="1">MEHKSTGARQAFRRFWPLTRGDRRWLVLIIVCVVVAALAETASILIFANLTDHALAAGSLSAFWLPAAQWLGVAVIGAAVGYAGNSLAVWTAERFVLRLRAGAFRHVQGLPPHFFQKHRQGDLVERLTGDVEAIEQMVVSGVVGTVSALFSTVFYAAAALWLRWDLALVTFLLAPLFLIAARRFAGRIRSAARDERTADGAITSVVEESLGNVVLTQAYNLRRDEERRLDREARAWLRASVRGARASELYEQFVEVVETLCVLAVIGFGAWEIAAGRMTLGDLLAFAAFIGYLYPPIRNLGQLGLTLTAATAGAERIQEVLDAEPAVTDPVSPRPAWPVRGRISLEGVSFRYPDAPAESLTDVSLTAEPGELVLITGESGAGKSTLSKLLLRFYDPTAGTVRLDGVPLTDVPLEFLRENVALLPQETLILHGTIRENIACGLPGAGEREIRQAALDAAAHEFITDLPEGYDTRIAPGTAALSGGQLQRIAIARAMLRGAPVLVLDEPTAGLDALATRRVVQPLRRLMAGRTTIVITHDLALAPDADRILVVDCGRLVESGTHRELLARGGAYARLRSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-05-25" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JVT8</accession>
    <name>A0A2M9JVT8_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 7">30S ribosomal protein S20</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">rpsT</name>
        <name evidence="9" type="ORF">CG723_17020</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CB01635</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Binds directly to 16S ribosomal RNA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the bacterial ribosomal protein bS20 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000004">
        <property type="protein sequence ID" value="PJN10867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN10867">
        <property type="protein sequence ID" value="PJN10867"/>
        <property type="gene ID" value="CG723_17020"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00500">
        <property type="entry name" value="Ribosomal_S20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002583">
        <property type="entry name" value="Ribosomal_S20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036510">
        <property type="entry name" value="Ribosomal_S20_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33398">
        <property type="entry name" value="PTHR33398"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01649">
        <property type="entry name" value="Ribosomal_S20p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46992">
        <property type="entry name" value="SSF46992"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00029">
        <property type="entry name" value="S20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5 7 9" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="4 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 7" id="KW-0699">rRNA-binding</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="39"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="74"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00015666"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PJN10867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="88" mass="9542" checksum="16A4E59A4E17B825" modified="2018-04-25" version="1">MANIKSQIKRIKTNEKARQRNKAVKSSLKTAIRKAREAVAAGDTQKAEELTREASRKLDKAVSKGVIHKNQAANKKSALASKASSLKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JVW2</accession>
    <name>A0A2M9JVW2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_08655</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN11045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN11045">
        <property type="protein sequence ID" value="PJN11045"/>
        <property type="gene ID" value="CG723_08655"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="59"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN11045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="97" mass="10909" checksum="614EDC422AF38FA2" modified="2018-04-25" version="1">MRYPPELRRKALDLLADGEPVKKVAVALGLSDQTVYQWRRRHLPHLSRGGPEPSTGTDLRAARRRIAQLESELAALRRATELLRDVVSPKGDSRQST</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JVY4</accession>
    <name>A0A2M9JVY4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CG723_08740</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CB01635</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN11056.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN11056">
        <property type="protein sequence ID" value="PJN11056"/>
        <property type="gene ID" value="CG723_08740"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002397">
        <property type="entry name" value="Cyt_P450_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00359">
        <property type="entry name" value="BP450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="SSF48264"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0349">Heme</keyword>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="231"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="389"/>
            <end position="408"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PJN11056.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="408" mass="45006" checksum="078D61D6259D25A7" modified="2018-04-25" version="1">MSQQPVLVPYADPAFMADPFPFYRQLREDGPVRRAVLAGGIEAWLVTRYEDGLAALSDSRLSSDVRDASDPRLLERLPATERESMLRTMLRSDPPDHTRLRRLVSKAFTARRVAELRPRVQEITDGLLDAIVPAGKAELVEDFALPLPVTVISELLGVPVADRNDFHRWTDDMILQGAEPPDPARMDRAWRQMRSYLTGLLQDKRARPGDDLLSALIATRDEEHQLDEDELIAMAFLLLVAGYITTVNLIGSGIAALLAHPDQLQMLRDDPELLPGAVEEFLRYDGPVNPGIARFAREDVAIAGVAIPRGATVLVASAIADRDPARFPDPDRMDITRQDNAHLAFGHGIHYCLGAPLARLEGQIAMGTALRRLPHLSLAVPPSELRWRSGGLRGPEQLPVTFTSDASS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JW96</accession>
    <name>A0A2M9JW96_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_09035</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN11102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN11102">
        <property type="protein sequence ID" value="PJN11102"/>
        <property type="gene ID" value="CG723_09035"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="46"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN11102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="69" mass="7277" checksum="0271CB7352AE3187" modified="2018-04-25" version="1">METPIALAAGAFLVALGLSLIHRLNAQHDARIAAYDFSDPFPAISRAPGRSHHRSTGQALSQGLTGAWP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JWK6</accession>
    <name>A0A2M9JWK6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ferric iron reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_10120</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN11280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN11280">
        <property type="protein sequence ID" value="PJN11280"/>
        <property type="gene ID" value="CG723_10120"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024726">
        <property type="entry name" value="FhuF_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11575">
        <property type="entry name" value="FhuF_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FhuF_C" evidence="1">
        <location>
            <begin position="210"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF11575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN11280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="244" mass="25749" checksum="061B2F193AFC53E0" modified="2018-04-25" version="1">MTVHIDLRELGSLGGFFALCDIEDAESDPPALGRVYQSDAPVRDPLAYRVEKVARALSVPEPRVAVSVAQLGLAARLWSVALGSAALFGRVPDLDPALLHWNPDASAPDDLFLAGTGQLPAGSAHLAELVLDRHLELLSAALRARYRVSAPLLRGNAGSALAGAAREISRWARRAGRPDVAARARLLTTELFADPRLAATGTRTGTAFRRTSCCLIYRAPGGGLCGDCCFERPPQHSSPPAASG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-05-25" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JX33</accession>
    <name>A0A2M9JX33_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CG723_10265</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CB01635</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN11307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN11307">
        <property type="protein sequence ID" value="PJN11307"/>
        <property type="gene ID" value="CG723_10265"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051604">
        <property type="term" value="P:protein maturation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009613">
        <property type="entry name" value="LMF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14463">
        <property type="entry name" value="PTHR14463"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06762">
        <property type="entry name" value="LMF1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="71"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="96"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="254"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="283"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PJN11307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="476" mass="54375" checksum="4EC58395F62CF422" modified="2018-04-25" version="1">MEWFSSPGYWLGRLIFQRGLAALYLVAFVGAALQFRALIGERGMLPVPRCLERVPWRQAPTLFRAYYSDRFFAGVAWGGAALSAALAAGLADRVPLWAAMALWVVPWVLYLSIVNVGQTWYAFGWESLLLEVGFLAVFLGNERVAPPLLVLVLLRWILFRVEFGAGLIKMRGDECWRKLTCLYYHHETQPMPGPLSWFFHRLPRPLHRVEAGANHVTQLVVPVLLFTPQPIATCAACLMILTQLWLVLSGNFSWLNWLTILLAVTAVDFSLLREPPHPAAAPLWYECVVIAVTALVVALSYHPALNLLSRRQSMNRSYDSLHLVNAYGAFGSVGRIRHEIVIEGTADPVPREESAWLVYEFRGKPGDPGRWPRQFAPYHLRLDWMMWFAALSPLYAESWFGGLVERLLTGDRDTLRLLRRSPFPADAPPTYVRARLYRYRFTTWRELRATGACWERTYVREFLRPTRLAASRSQSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JXN8</accession>
    <name>A0A2M9JXN8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Acyl-CoA dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CG723_12255</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CB01635</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN11646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN11646">
        <property type="protein sequence ID" value="PJN11646"/>
        <property type="gene ID" value="CG723_12255"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003995">
        <property type="term" value="F:acyl-CoA dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006089">
        <property type="entry name" value="Acyl-CoA_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="SSF47203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="SSF56645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00073">
        <property type="entry name" value="ACYL_COA_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0274">FAD</keyword>
    <keyword evidence="3 5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA_dh_N" evidence="8">
        <location>
            <begin position="7"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_M" evidence="7">
        <location>
            <begin position="123"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_1" evidence="6">
        <location>
            <begin position="235"/>
            <end position="383"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PJN11646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="385" mass="41644" checksum="CD60E1E930E9CECE" modified="2018-04-25" version="1">MPCTVFNEEHEAFRQVVRDFLAKEAVPHLQDWVAVKAVSRDFYRKLGELGILGIEVPEEYGGGAETGHHFGAVFAEEVARAGATVGTAMTHANIILPYLLHFGTEEQKRRWVPGCVSGDIMLSIAMTEPGTGSDLAGIQTKAVLSEDGTHYVLNGAKTFITGGIQCDLVLVVCRTSPAPADNRREGLSVLVVDTTSEGYAVGRSLDKVGLHASDTAELSFTDVKVPVGNLLGEEGEGFFYLGRNLARERLVIAVQAAAAAEAAVRFAKEYTQDRTVFGRSVASFQNTKFVLAECATEVEAARLMAYEALERDARGELSADYAAMAKLLCTETAGRVIDKCLQLHGGYGYMLEYPIARLYADTRVMRIYGGTSEVMKTIIAKSIGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JXU2</accession>
    <name>A0A2M9JXU2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">FAD-binding monooxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_12645</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN11706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN11706">
        <property type="protein sequence ID" value="PJN11706"/>
        <property type="gene ID" value="CG723_12645"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD_binding_3" evidence="1">
        <location>
            <begin position="110"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN11706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="403" mass="45109" checksum="72DDFFD9754510A9" modified="2018-04-25" version="1">MKVVCVGGGPATLYFSILLKLQAPSHDITVFERNPAGSTYGWGVTYWPDMLERLRRHDPHSASTISDGSLRWRDGVAHVGQRTTTHEGDEGFAIGRHRLLDILARRAESLGVAIEYGHEIQDREQLPEADLVVAGDGANSRMRERRAGHFGTQTTLGSNPYLWLGTTKVFRSFTFAFAETAHGWIWCYAYGYSGEHSTCVVECSKATWQGLELDRLPQPQALRRLEGIFASLLDGHALIGRSDHDGPAPWQNFRTLTNRTWSHGNLVLLGDAAHTTHYSIGAGTTLAMQDAMVLASSLTEAKTIQPALSLYEHTRKSELLSVQSAARHSAQWYENLPRYIQLPPAHMFALLGQRHSPLLPHIPPQLYYRIDRAADQLQSLRRLKQWLGPRLARTLQHRNSARG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JY96</accession>
    <name>A0A2M9JY96_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">FAD-dependent oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CG723_13380</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN11828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN11828">
        <property type="protein sequence ID" value="PJN11828"/>
        <property type="gene ID" value="CG723_13380"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PJN11828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="475" mass="49987" checksum="6BC059C5334EF5D8" modified="2018-04-25" version="1">MTSAVIVGGGPNGLAAGALLAKAGLEVTLLEAADEVGGGTRSHEAVLPGLLHDHCSAIHPMAVTSPALRSLGLERHGLRWKLADVDCVHPLDDGSAGVLMRSVEDTARMLGADAGRYRALFETPVRHWDALAQDVMRPLLRVPTHPLLLARFGLPTALPATVLARLFRTPQAQALWAGVAAHAFRPLTHPFTSAIGLGILTAGHAAGWAVAEGGSQSIARSLGNVLGEHGGTIHTGVHITRSSQIPPADVTLLDLDPGQIARIYGDRLPARVRSAYRRFRRGPGAFKVDLAVEGGVPWTNEDARRSGTVHLGGPFADVARGERDVVAGRMPERPFVLVGQQYLADPTRSVGDVHPVWAYAHVPYDYDGDATEAILRQFERFAPGVRERIVGRHITRPADFAAANPNFVGGDIVTGANTVPHLLLGPRPALDPYGTGLPGVFICSAATPPGPAAHGMCGAGAARSALRHLGLRQPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JYJ1</accession>
    <name>A0A2M9JYJ1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">LacI family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CG723_14060</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN11940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN11940">
        <property type="protein sequence ID" value="PJN11940"/>
        <property type="gene ID" value="CG723_14060"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001034">
        <property type="entry name" value="DeoR_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046335">
        <property type="entry name" value="LacI/GalR-like_sensor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018356">
        <property type="entry name" value="Tscrpt_reg_HTH_DeoR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08220">
        <property type="entry name" value="HTH_DeoR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13377">
        <property type="entry name" value="Peripla_BP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00037">
        <property type="entry name" value="HTHLACR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00420">
        <property type="entry name" value="HTH_DEOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00894">
        <property type="entry name" value="HTH_DEOR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51000">
        <property type="entry name" value="HTH_DEOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH deoR-type" evidence="5">
        <location>
            <begin position="5"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="361"/>
            <end position="387"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PJN11940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="387" mass="40592" checksum="41C6570C947D267A" modified="2018-04-25" version="1">MREPVDLRRQRILAVVQSRGATRVSDLAAELAVSVVTLRRDVEELAREGKLRRGHGVARPVLPETDQAAAPVEPMADGGPVAVVVPERHSYLYEALHGARTAFEEAGIRIALHIAPAVAGAEQPIVEQALAAGARGLLIAPRWRSRATEEADYTWLASLPVPAVVMERRPRRGSALHAVDTVCTDHWYGIHLAVEHLTGLGHRRIVLAARDDSPTARALRAAFVEIAADHPDVDKWAVALSSPGAAPDPAAEAAEKPIELPGLLAELGATAAVLHGDVDALMLVQSLRDGGVRVPEDCSVIAYDDVVAGLGSTPLSAVSPPKAEVGRAAAELLLRRLGGQSSASGAEPARRLELLPTLQVRGSTQAPHTAESHASDTTGTGGTTAAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JYL1</accession>
    <name>A0A2M9JYL1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Beta-glucosidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_14155</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN11955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN11955">
        <property type="protein sequence ID" value="PJN11955"/>
        <property type="gene ID" value="CG723_14155"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001360">
        <property type="entry name" value="Glyco_hydro_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033132">
        <property type="entry name" value="Glyco_hydro_1_N_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10353">
        <property type="entry name" value="PTHR10353"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00232">
        <property type="entry name" value="Glyco_hydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00131">
        <property type="entry name" value="GLHYDRLASE1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00653">
        <property type="entry name" value="GLYCOSYL_HYDROL_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN11955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="488" mass="54071" checksum="CC4454942D594C41" modified="2018-04-25" version="1">MSTPAFPEFPDGFFFGAATASYQIEGAYGEGGRGPSIWDTFCREPGRVAGGATGDIACDHYHRYREDVALLRGLGVDSYRFSVAWPRIQPDGTGPANAAGLDFYDRLVDELLASGISPATTLYHWDLPQALEDRGGWRVRETAERFADYAGLVVERLGDRVGRWITLNEPFCSAFVGYAAGAHAPGAREGRGALAAAHHLLVGHGLAVRALREAGAQEVGITLNPDRLLATTPGSPADLAAVRRAETLHNEVWLDPLFAGRYPQHEAETWGEPANGSSRSDSSCGLDTSYRLDTSYRLDGDLELVAAPLDFVGINYYRPITVADAPHRDPDPATRTAVDIRVAETWRDDVRHTTMGWPVVPHTFTDLLVDLTKRYPELPPLVITENGSAEADTVTDDRRVHDTDRIEYLRSHLEALSAAIRAGVDVRGYYVWSLLDNFEWARGYGQRFGIVRVDYDTQERVPKDSYRWFRDLIATHRARTTTADKDHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JZ44</accession>
    <name>A0A2M9JZ44_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CG723_11090</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN12152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN12152">
        <property type="protein sequence ID" value="PJN12152"/>
        <property type="gene ID" value="CG723_11090"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019475">
        <property type="term" value="P:L-lysine catabolic process to acetate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008567">
        <property type="entry name" value="KCE_family"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37418">
        <property type="entry name" value="PTHR37418"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05853">
        <property type="entry name" value="BKACE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PJN12152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="352" mass="38660" checksum="C92799ECEB1B0E1B" modified="2018-04-25" version="1">MHFLDDSLLPENQQKLVIQAAPYGPEWLPGDADDLPLTMDEHVQAAVDCYNAGATVLHIHVRELDGHGSKRMSMFNELIGRLREAVPDMVLQIGGSISFAPEDEGSEAKWLSYDTRHLLAELDPRPDQVTIAINTSQMNIVEIMSDDDLAGTSIAKPDYYAAYRDMVVEAGPDFYLEHLERLHANDIQPHFQLATLAQLETVERLIRSGVYTGPLVLNYVAIGGGFSGRHPADLIEFVRRVPDGAVLTIESSMRAVAPMNAIAIALGVHVRVGNEDNLWARKGEPMSSVQQVEQMVSIADTLGRDIANGAEAKEIYHIGEYYTGTDETLAALGMVPNRRPGQRGFMLGGSTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JZ57</accession>
    <name>A0A2M9JZ57_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ABC transporter substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_11040</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN12150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN12150">
        <property type="protein sequence ID" value="PJN12150"/>
        <property type="gene ID" value="CG723_11040"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015168">
        <property type="entry name" value="SsuA/THI5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09084">
        <property type="entry name" value="NMT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014734759" evidence="1">
        <location>
            <begin position="21"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="domain" description="NMT1" evidence="2">
        <location>
            <begin position="81"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN12150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="437" mass="45930" checksum="976B39062D4B06F6" modified="2018-04-25" version="1">MLPLALLLPLATACGGAAGAEDSHTVTVTVGYQSKTINTVTAGTLLRSLGYFEEELAARGRKDGKTYKVKWQDYATGAPITAQMTAGKIDIGSMGDFPLLINAARGKQLGQPTRLVSVTGYNLHGGLNTIVTTPGSPLRSLDDLRGKKVSTSVGSAADGTLVRALKEAGIDPEKGISKLNQQPSVGASALTGGSVDALSQFVAWPGQLTYEGKAQALYDGADLNLPTFHGVTVREKFAEGRAGVLDDFLQAQRRATDHLRKRPVAAAESVAKETGLPAEAVYLYNGAHGIATFDPALRPELIAALKKDVPILKAANLVGDVDVDSFVDPEPLKRAGHTPSYPKAGGAKSELWLKGQGTTRTFDSPKQLLKAAKGAEVRAAYVPDALTGTLWFADKSVWVANGSDLRAFVTPSHARTYVERHAGARVVSYADAVGLAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JZ92</accession>
    <name>A0A2M9JZ92_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Aldehyde dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CG723_12315</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CB01635</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN12178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN12178">
        <property type="protein sequence ID" value="PJN12178"/>
        <property type="gene ID" value="CG723_12315"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016620">
        <property type="term" value="F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016160">
        <property type="entry name" value="Ald_DH_CS_CYS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="SSF53720"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00070">
        <property type="entry name" value="ALDEHYDE_DEHYDR_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00687">
        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldedh" evidence="5">
        <location>
            <begin position="19"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="256"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PJN12178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="489" mass="51013" checksum="59E80AFF123D4A93" modified="2018-04-25" version="1">MTDSNAVVEHRTLFIGGRWAEPAGRDTIEVISPVTERVVGRVPHATPEDVDLAVAAAREAFDHGPWPRLPLKERIEVVTRIKDALAARHQELAELITLQNGSPMLFSVRGQALSAVGTFGVAIAAAGRIQEEEERQGAGGPVLVRREPVGVVAAITPWNVPQLTIAGKLAPALLAGCAVVLKPSPETPLDALWLAQVCADAGLPEGVLSVLPADRETSSYLVAHPGIDKVAFTGSVGAGKAIAAAAARNLTRVSLELGGKSAAILLDDADLSVAVPAIVGGTCAANSGQACVALTRILVPAARYDEVAAVLTGAFAGLKVGDPSDPGTVVGPMVTRKQQERNLDYIRIGREEGAKVLTGGGVPSGLTTGWYVEPTLFGDVTNDMRIAREEIFGPVVCLIRYETEDEAVALANDSEFGLSGAVFGADEARATEVARKVRTGTITVNGFRLDLAAPFGGYKNSGIGREFGPEGLAAYFEYKTVNLPAPAKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JZC2</accession>
    <name>A0A2M9JZC2_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Biotin transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CG723_09180</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CB01635</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the BioY family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN12107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN12107">
        <property type="protein sequence ID" value="PJN12107"/>
        <property type="gene ID" value="CG723_09180"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015225">
        <property type="term" value="F:biotin transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003784">
        <property type="entry name" value="BioY"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34295">
        <property type="entry name" value="PTHR34295"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02632">
        <property type="entry name" value="BioY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016661">
        <property type="entry name" value="BioY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="2 3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="33"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="57"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="81"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="104"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="138"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="180"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRNR" id="PIRNR016661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PJN12107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="211" mass="20990" checksum="B7B54638FF68CF1D" modified="2018-04-25" version="1">MSTITSPTPRPAVRVLADLLPAEGAARTRARDAALVLGGAALTGIAAQFAVPVPGSPVPVTGQTFAALLVGIALGARRGALALAVYAGAGVCGMPWFAEGTSGAAMPTFGYVVGLVLAAAVVGDLARRGGDRSPLRTAGVMAVGTFCVYAVGVPYLALSLHLSLDRAVALGSAPYLVGDALKAALAMGALPAVWRVLGNSRADDGQADLSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-09-29" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JZV5</accession>
    <name>A0A2M9JZV5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Cytosine permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CG723_05035</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CB01635</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the purine-cytosine permease (2.A.39) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000002">
        <property type="protein sequence ID" value="PJN12411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN12411">
        <property type="protein sequence ID" value="PJN12411"/>
        <property type="gene ID" value="CG723_05035"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015209">
        <property type="term" value="F:cytosine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030191">
        <property type="entry name" value="CodB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001248">
        <property type="entry name" value="Pur-cyt_permease"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30569">
        <property type="entry name" value="PTHR30569"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02133">
        <property type="entry name" value="Transp_cyt_pur"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="33"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="62"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="105"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="138"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="162"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="200"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="234"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="265"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="315"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="340"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="383"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="409"/>
            <end position="429"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PJN12411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="456" mass="48034" checksum="3AF851C01C067505" modified="2018-04-25" version="1">MTATDTETKRLGSDDYSLTRVPRDQRLGFWTMLLQWLAQSGSISQFTLGATIGVGMTFGNAFLAFTLGAVILEVVIFAIGLAGMREGLATPMLTRWIGFGRNGSALVSFVIAVSLVGWFGVQNTIFGNSVSALVGGPSWVWCVAAGLAITVLVIFGFRYMALFAKIVTPLFFALVAWSVTNALMDHSVGDLISSPAPGQTIPLAVAATAIAGGYMTGAIVSPEMTRYNRKGSHVFLQSASSMILSEYIVGLTGVLLGHLVKSSEVSHIVLSTSGAFGVIVVLMSTAKINDWNLYGSSLGVVNFFQVVFGKRLHRGAVTVALGLAGTLLSAVGIMTHFTEFLSVLGVAIPPIGGIIVAEYWVVRRMRKPLDETREAGTLPASSPTWVPMSIVIWIAAFCVGKYVTVGIPALNSLATAFVLYAVLGLLGLVRPYGTSALDDEDTTVPAAPEATPVGAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-05-25" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JZW0</accession>
    <name>A0A2M9JZW0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CG723_05055</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CB01635</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000002">
        <property type="protein sequence ID" value="PJN12415.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN12415">
        <property type="protein sequence ID" value="PJN12415"/>
        <property type="gene ID" value="CG723_05055"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008969">
        <property type="entry name" value="CarboxyPept-like_regulatory"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49464">
        <property type="entry name" value="SSF49464"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="52"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="83"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="108"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="140"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="168"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="201"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="232"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="270"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="310"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="342"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="367"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="405"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="443"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="17"/>
            <end position="467"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PJN12415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="585" mass="60092" checksum="AC599402AC871422" modified="2018-04-25" version="1">MTQTTQRPTAQRGIRGVVPVLAFAGITVAVMQTLLVPVIKDLPVLLGTAPSNATWVLTSTLLAGAVSTPIMGRLGDLYGKRRMLLTSLAIMVVGSLVAGFTSDLLVMIVGRALQGFAMGAIPLGIGLMRDELPREKLGSAMALMSSSIGVGGGLALPLAALVAQHADWHALFFGAAGLGVVAILLTLFFVPESSVKAEGSFDVLGAIGLSAGLVLLLLPITKGSDWGWTDPMTLGLFGAALVVLVLWGVMELKLKAPLVDLRTTARREVLLTNLASIMVGVAFYAISLVLPQLLQLPKATGYGLGQSMVVAGLCVAPLGLTMMFTAPVYARLSAKYGPKTTLILGMLIIAIGYGAGLGLMSAAWQTIVISVVVGAGIGLAYSSLPALIIGAVDASETGAANGLNTLMRSIGTSVSSAVIGMVLANTANHVGGAAVPTMHGFRVSFLIATAAVAMGVLLAVFLPKQRQATKPQLRASSEEDAALERAEEILGGFRGQVLDAAGLPVSRAKVTLIDRRGRQAGAALTDHTGRYALEVPAGGSYVLAATAAGHAPRASAATHHGEDRPVDVDLALELIAPESRTAARS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K091</accession>
    <name>A0A2M9K091_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 6">Glutamine synthetase</fullName>
            <ecNumber evidence="6">6.3.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CG723_05610</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CB01635</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>ATP + L-glutamate + NH4(+) = ADP + H(+) + L-glutamine + phosphate</text>
            <dbReference type="Rhea" id="RHEA:16169"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.1.2"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the glutamine synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.1.2" evidence="6"/>
    <dbReference type="EMBL" id="NNBL01000002">
        <property type="protein sequence ID" value="PJN12510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN12510">
        <property type="protein sequence ID" value="PJN12510"/>
        <property type="gene ID" value="CG723_05610"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004356">
        <property type="term" value="F:glutamate-ammonia ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006542">
        <property type="term" value="P:glutamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008147">
        <property type="entry name" value="Gln_synt_b-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036651">
        <property type="entry name" value="Gln_synt_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014746">
        <property type="entry name" value="Gln_synth/guanido_kin_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008146">
        <property type="entry name" value="Gln_synth_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027303">
        <property type="entry name" value="Gln_synth_gly_rich_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027302">
        <property type="entry name" value="Gln_synth_N_conserv_site"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00120">
        <property type="entry name" value="Gln-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03951">
        <property type="entry name" value="Gln-synt_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01230">
        <property type="entry name" value="Gln-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54368">
        <property type="entry name" value="SSF54368"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55931">
        <property type="entry name" value="SSF55931"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00180">
        <property type="entry name" value="GLNA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00181">
        <property type="entry name" value="GLNA_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gln-synt_C" evidence="7">
        <location>
            <begin position="89"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU004356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM01230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PJN12510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="343" mass="37341" checksum="6932C149834A62A4" modified="2018-04-25" version="1">MTFKAEYIWIDGTQPTAKLRSKTKIIAGSAPALEELPIWGFDGSSTSQAKGHASDRVLRPVASYPDPIRGGDDILVMCEVLNIDMTPHESNTRAALAEVAEQFAAQESIFGIEQEYTFFEGERPLGFPVGGFPAAQGGYYCGVGADEIFGRDVVEAHLDNCLKAGLGISGINAEVMPGQWEFQVGPLAPLEVSDQLWVARWLLYRTAEDFNISATLDPKPVKGDWNGAGAHTNFSTKAMREGYEAIITACESLGEGSKPMDHVKNYGAGIDDRLTGLHETAPWNEYSYGVSDRGASVRIPWQVEKDGKGYIEDRRPNANVDPYVVTRLIVDTCCTALEKAGQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K0C0</accession>
    <name>A0A2M9K0C0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Hydrogenase expression protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_05845</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000002">
        <property type="protein sequence ID" value="PJN12554.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN12554">
        <property type="protein sequence ID" value="PJN12554"/>
        <property type="gene ID" value="CG723_05845"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2090.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027463">
        <property type="entry name" value="AcrB_DN_DC_subdom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001036">
        <property type="entry name" value="Acrflvin-R"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32063">
        <property type="entry name" value="PTHR32063"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00873">
        <property type="entry name" value="ACR_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00702">
        <property type="entry name" value="ACRIFLAVINRP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82714">
        <property type="entry name" value="SSF82714"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="333"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="359"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="383"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="430"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="462"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="532"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="852"/>
            <end position="871"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="878"/>
            <end position="898"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="904"/>
            <end position="929"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="950"/>
            <end position="970"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="982"/>
            <end position="1008"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1017"/>
            <end position="1051"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN12554.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="1051" mass="109650" checksum="5D13EF7C5466D67F" modified="2018-04-25" version="1">MSWLSRFSLAQRALIGLMSIIAIVFGAIAIPQLKQQLLPSIELPMVSVLAPYQGASPDVVEKQVIEPLESTIDAVDGITGITSTASEGNAVIMAQFDYGNGSKQLVADVQQAVNRARAQLPDDVDPQVVAGSTDDIPTVVLAVTSDKDQQALADQLDKTVVPSLKDIDGVGQVTVDGVRDLQVTVTPDDKKLAAAGVSQAALGQSLQAGGATLPAGSFDEGGSNRTVQVGGGFTSLKQIQDLMVTGEGVRKPVRLGDVAKVAQQPAKADSITRTDGKPSLAVMVTMDHDGSAVAISDAVKDKLPDLRKDLGTGAKLTVVSDQGPAVSKSIDGLTTEGALGLLFAVLVILVFLASIRSTLVTAVSIPLSVVLALIVLWTRDLSLNMLTLGALTIAIGRVVDDSIVVLENIKRHLGYGEERQEAILKAVREVAGAVTSSTLTTVAVFLPIGLVGGMVGELFGSFSLTVTAALLASLIVSLTVVPVLSYWFLRPPKAIKGVDPEEARRKAEEKEARSWLQRIYVPVLRFATRRRLTSVLIAVVVLVGTFGMAPMLKTNFFDQGEQEVLSIKQELKPGTSLAATDAAAKKVEKLLDGVDSVKDYQVTIGSSGFMAAFGGGTDTNQASYQVTLKGKASYEKTQDRIEKGLGELSGIGRTTIAAGDGFGSQDLSVVVKAADGQVLRKAADEVRAEVAELDDVTDVTSDLSQSVPRISVRANSKAAASGFNDTTLGAAVGQAVRGTTSGKAILDDTERDVVVKSAKPATTMAELKKLPMGPGGLKLGDIATVKLVDGPVSMTRIDGARAATITAKPTGDNTGAVSADLQTKIKALKLPAGATATIGGVTSDQDDAFKNLGLAMLAAIAIVFMLLVATFRSLAQPLILLVSIPFAATGAIGLLIATGTPMGVPAMIGMLMLIGIVVTNAIVLIDLINQYRKEGYGTIEAVIEGGRHRLRPILMTALATIFALLPMALGVTGEGGFIAQPLAVVVIGGLITSTLLTLLLVPTLYAMLELRKERRRKKREAKRAQKAGVPAEQEAAQASEAESGEPEPAQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K0U7</accession>
    <name>A0A2M9K0U7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CG723_07015</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000002">
        <property type="protein sequence ID" value="PJN12755.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN12755">
        <property type="protein sequence ID" value="PJN12755"/>
        <property type="gene ID" value="CG723_07015"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PJN12755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="150" mass="16000" checksum="193E023D9192DD17" modified="2018-04-25" version="1">MGVVTTRTMDLDSLVRFSRQRQVLRTAPLRLAVPDGMTAPLGCDAVAVPEACGRAMVARLPRMGCVYADGDRWWWIVPSDSDVALEWPAPASYTTGALVPDARRAPGLIHRPDGSVPYTPPIPLYLALCRVTGTTPAWSRSIGAGAADAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K0W1</accession>
    <name>A0A2M9K0W1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF397 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_07030</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000002">
        <property type="protein sequence ID" value="PJN12758.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN12758">
        <property type="protein sequence ID" value="PJN12758"/>
        <property type="gene ID" value="CG723_07030"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007278">
        <property type="entry name" value="DUF397"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04149">
        <property type="entry name" value="DUF397"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF397" evidence="1">
        <location>
            <begin position="29"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN12758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="90" mass="9517" checksum="AF4E5F6EA64E6D1B" modified="2018-04-25" version="1">MDRIKARIRGVDGKVIYNGMPARELGNEGWHKPWSGGNGGNCVEAMKLADGRVAMRQSADPDGPALIYTPGEITAFIEGAKAGAADFLLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K152</accession>
    <name>A0A2M9K152_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CG723_07505</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000002">
        <property type="protein sequence ID" value="PJN12849.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN12849">
        <property type="protein sequence ID" value="PJN12849"/>
        <property type="gene ID" value="CG723_07505"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014036">
        <property type="entry name" value="DeoR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001034">
        <property type="entry name" value="DeoR_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00455">
        <property type="entry name" value="DeoRC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08220">
        <property type="entry name" value="HTH_DeoR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00037">
        <property type="entry name" value="HTHLACR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00420">
        <property type="entry name" value="HTH_DEOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="SSF100950"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51000">
        <property type="entry name" value="HTH_DEOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH deoR-type" evidence="3">
        <location>
            <begin position="6"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PJN12849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="256" mass="27374" checksum="13AE612A6316104A" modified="2018-04-25" version="1">MHSMSAEERQREIVRAARRSGSVDVTVLAARLGVAKETVRRDLRALEDHGLVRRTHGGAYPVESAGFETTLAFRTTMHVPEKRRIAAAAAELLGDAETVFVDEGFTPQLIAEALPRDRPLTVVTASLATAGALAEAENTTVLLLGGRVRSGTLATVDHWTTKMLAGFVIDLAFIGANGISREHGLTTPDPAVSEVKAQAVRASRRTVFAGVHTKFGAVSFCRFAPVSSLEAIVTSTQLPASEAHRYALQGPQVIRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K1C3</accession>
    <name>A0A2M9K1C3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_07930</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000002">
        <property type="protein sequence ID" value="PJN12924.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN12924">
        <property type="protein sequence ID" value="PJN12924"/>
        <property type="gene ID" value="CG723_07930"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021449">
        <property type="entry name" value="DUF3099"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11298">
        <property type="entry name" value="DUF3099"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="30"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="54"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="98"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="111"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN12924.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="128" mass="13784" checksum="55CCE190C94F9E4C" modified="2018-04-25" version="1">MRKQSSSEVFRITGARQGLADDVRGRQRRYVISMSVRTLAVILGAALWNVERPVAIVALVLGLLLPYVAVVIANAGRENVPSLPSTFVTAPMRPMLSAPAATAPAESVPKENTGAHDEERRDHLGDRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K1X0</accession>
    <name>A0A2M9K1X0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Peptidase M16</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CG723_00505</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000001">
        <property type="protein sequence ID" value="PJN13118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN13118">
        <property type="protein sequence ID" value="PJN13118"/>
        <property type="gene ID" value="CG723_00505"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011249">
        <property type="entry name" value="Metalloenz_LuxS/M16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011765">
        <property type="entry name" value="Pept_M16_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007863">
        <property type="entry name" value="Peptidase_M16_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00675">
        <property type="entry name" value="Peptidase_M16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05193">
        <property type="entry name" value="Peptidase_M16_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63411">
        <property type="entry name" value="SSF63411"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase_M16" evidence="2">
        <location>
            <begin position="26"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M16_C" evidence="3">
        <location>
            <begin position="185"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="429"/>
            <end position="469"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PJN13118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="469" mass="51084" checksum="64CE6E4548D6A512" modified="2018-04-25" version="1">MGHTATAEAGSGGLTATEHRLANGLRVVLSEDHLTPVAAVCLWYDVGSRHEVKGRTGLAHLFEHLMFQGSKQVHGNGHFELVQGAGGSLNGTTSFERTNYFETMPTHQLELALWLEADRMGSLLAALDEESMENQRDVVKNERRQRYDNVPYGTAFEKLTALVYPEGHPYHHTPIGSMADLDAATLEDARNFFRTYYAPNNVVLSVVGDIDPEQTLAWVEKYFGSIPRHDGKQPPRDGALPDLIGEGVREVIEEEVPARALMAAYRLPQDGTRACDAADLALTVLGGGESSRIYNRLVRRDQTAVAAGFGLLRLAGAPSVGWLDVKTSADVEVPVIEEAVDEELARFAADGPTPEEMERAQAQLEREWLDRLGTVSGRADELCRFAVLFGDPQLALTAVQRVLDVTAEEVQEVAKAHLRPDNRAVLVYEPTAPEEDDATAEASSTDEAADETVGETADAIETADKEAGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-05-25" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K1X8</accession>
    <name>A0A2M9K1X8_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Lysine N-acyltransferase MbtK</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Mycobactin synthase protein K</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CG723_00285</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CB01635</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Acyltransferase required for the direct transfer of medium- to long-chain fatty acyl moieties from a carrier protein (MbtL) on to the epsilon-amino group of lysine residue in the mycobactin core.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Siderophore biosynthesis; mycobactin biosynthesis.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000001">
        <property type="protein sequence ID" value="PJN13080.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN13080">
        <property type="protein sequence ID" value="PJN13080"/>
        <property type="gene ID" value="CG723_00285"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00011"/>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019290">
        <property type="term" value="P:siderophore biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019432">
        <property type="entry name" value="Acyltransferase_MbtK/IucB-like"/>
    </dbReference>
    <dbReference type="SMART" id="SM01006">
        <property type="entry name" value="AlcB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AlcB" evidence="6">
        <location>
            <begin position="132"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="64"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003818"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00031122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM01006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PJN13080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="299" mass="31410" checksum="1341B578D91A6D48" modified="2018-04-25" version="1">MSSTDARTDAGVTPATAPTDAVTDEITDTGPGADELTGSDPGGGTDVADTLDLRLPDELIDLIAGQDEPGGQINGSAGEGTDAGSGDYGHAGDGTRAHVPGGTSTALADDDLLDNVGAWRPVTTRSGVFQLVPVRVERDLALISRWMNDPAVAAFWELEGPESVTENHLRPQLDGDGRSVPCLGVLDGTPMSYWEIYRADLDPLARHYPARPHDTGVHLLIGGVANRGRGLGTGLLKAVADLVLDHRPRCARVVAEPDLRNTPSVSAFLGAGFRFSAEVDLPDKRAALMIRDRALRALL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K246</accession>
    <name>A0A2M9K246_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="11">3' terminal RNA ribose 2'-O-methyltransferase Hen1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CG723_00955</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CB01635</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000001">
        <property type="protein sequence ID" value="PJN13193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN13193">
        <property type="protein sequence ID" value="PJN13193"/>
        <property type="gene ID" value="CG723_00955"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008171">
        <property type="term" value="F:O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008173">
        <property type="term" value="F:RNA methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1610.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024026">
        <property type="entry name" value="3'-RNA_MeTfrase_Hen1_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026610">
        <property type="entry name" value="Hen1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024740">
        <property type="entry name" value="Hen1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038546">
        <property type="entry name" value="Hen1_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013217">
        <property type="entry name" value="Methyltransf_12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21404">
        <property type="entry name" value="PTHR21404"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12623">
        <property type="entry name" value="Hen1_L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08242">
        <property type="entry name" value="Methyltransf_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04074">
        <property type="entry name" value="bacter_Hen1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 11" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Hen1_L" evidence="10">
        <location>
            <begin position="1"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="domain" description="Methyltransf_12" evidence="9">
        <location>
            <begin position="303"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="456"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="474"/>
            <end position="489"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF08242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF12623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PJN13193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="499" mass="54974" checksum="7E4DA936D144ED71" modified="2018-04-25" version="1">MFLTISTTGTAERPATDLGFLLHKHPDNAQAFSTSHGTAHVLYPEASPERCTAALLLEVDPVALVRRGKGKGRGGAPDAALAQYVNDRPYAASSLLAVAIGSVFSSALRGQCKAMPERAEQPMPLRIEVPAVPARGGAALVRRLFEPLGWTTVTADPVALDEQFPEWGDSRYVRLVLEGELRLAEALRHLYVLLPVLDDAKHYWVSADEVDKLLRAGEGWLPTHPEQKLITSRYLSRRWALTRSAMERLELVRLANADDTDVEAIDNAVDEATDTEEQPVPLAVQRRDAITAALRAAGAGRVLDLGCGQGQLVHELLKDTRFTEIVGVDVSIRALTIAARRLKIDRMGERRAARVTLLQGSLAYTDKRLKGYDAAVLSEVIEHLDLPRLPALEYAVFGSARPRTVLVTTPNVEYNVRWETLPAGHVRHGDHRFEWTREEFRTWARAVAERHGYDVEFEPVGPDDPEVGPPTQMAAFTLTDQTPTDRTPTDPSPKEAKAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K274</accession>
    <name>A0A2M9K274_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glyoxalase/bleomycin resistance/extradiol dioxygenase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_00550</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000001">
        <property type="protein sequence ID" value="PJN13127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN13127">
        <property type="protein sequence ID" value="PJN13127"/>
        <property type="gene ID" value="CG723_00550"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041581">
        <property type="entry name" value="Glyoxalase_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18029">
        <property type="entry name" value="Glyoxalase_6"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VOC" evidence="1">
        <location>
            <begin position="12"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="domain" description="VOC" evidence="1">
        <location>
            <begin position="140"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN13127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="268" mass="28308" checksum="556430DABC0B573E" modified="2018-04-25" version="1">MTEAAARRAPGTPCWVSLMVHGMAATQEFYAALFGWEFRPGPQQLGPYVRALLDGHEVAGIGQMPPDRHLPVAWTPYLASDDVDATAESIRHCGGTVGVGPLDAGEAGRMAIASDPAGAVFGIWQAAEHLGMALTGVPGAPAWNELVTQETASVAKFYEAAFGYEEEAVVSADFDYLTLHLNGSPVASVHGVGQALPRDRGAHWMTYFEVADVDESVSLVEELGGHVLKPARDGSQGRLATVADPEGAVFTLVRSAPREEDQGLLTDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K2J0</accession>
    <name>A0A2M9K2J0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Homocysteine S-methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CG723_01810</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CB01635</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="3">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000001">
        <property type="protein sequence ID" value="PJN13341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN13341">
        <property type="protein sequence ID" value="PJN13341"/>
        <property type="gene ID" value="CG723_01810"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047150">
        <property type="term" value="F:betaine-homocysteine S-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009086">
        <property type="term" value="P:methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017226">
        <property type="entry name" value="Betaine-hCys_S-MeTrfase_BHMT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003726">
        <property type="entry name" value="HCY_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036589">
        <property type="entry name" value="HCY_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02574">
        <property type="entry name" value="S-methyl_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037505">
        <property type="entry name" value="Betaine_HMT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82282">
        <property type="entry name" value="SSF82282"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50970">
        <property type="entry name" value="HCY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1 4 6" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4 6" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Hcy-binding" evidence="5">
        <location>
            <begin position="3"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3 4">
        <location>
            <position position="224"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="287"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="288"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR037505-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PJN13341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="304" mass="31684" checksum="324358886EED32D8" modified="2018-04-25" version="1">MTSPPLAEALASGPVVLDGGLSNQLESAGYDLSDELWSARLLTERPEAIVAAHLAYYEAGASVAITSSYQATFEGFARRGVSRERAAELLALSVELAREAARRAEAKGVPGPLWVAASAGPYGAMLADGSEYRGRYGLTVAELEAFHRPRLEVLASAGPDLLALETVPDTDEARALLRAVRGLGVPAWLSYSVAGDRTRAGQPLEEAFALAADADEIVAVGVNCCAPEEVEPAVALAARVTGKPVVAYPNSGESWDAGARGWRGAATFTADRVAGWERAGARLIGGCCRVGPDRIAALAAAVRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K2J9</accession>
    <name>A0A2M9K2J9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_01820</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ROK (NagC/XylR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000001">
        <property type="protein sequence ID" value="PJN13343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN13343">
        <property type="protein sequence ID" value="PJN13343"/>
        <property type="gene ID" value="CG723_01820"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000600">
        <property type="entry name" value="ROK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18964">
        <property type="entry name" value="PTHR18964"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00480">
        <property type="entry name" value="ROK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01125">
        <property type="entry name" value="ROK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN13343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="408" mass="41817" checksum="F008DB7B6D60DC3C" modified="2018-04-25" version="1">MKRTSRDIRTANRYAVLRHLIAKSPASRGELTGGTGLSQATVATLVGELTALGLLVEVGFEESAGGRPRSLVAVDAAGGALIGVDVAETYVHAELFDLALGVVARAEEELRPGESAPEQVVGRIAAAVGAVVAAAGPRRPPRVLGVGVTMPGQVDRERGVAVRAANWGWRDVPLTALLAERFPYPVHLDNPLRAATLAELWFGAARGRDDAVVINLGTGVGAGLALGGSLHRGVTNSAGEWGHTTLVLDGRPCRCGDSGCVEAYVGAPAIMRTLRELAPESALLTDDDQTATIGALGRAAAGGDPVALRVVRETARHLGAAVADLVNLLNPEVIVLSSWVAAALGTPLLTEVREAVARHALGSPFAATEIVLSPIPTDPVSLGAATFALEGVLSSPGPTGTTLTPHTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-09-29" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K3B9</accession>
    <name>A0A2M9K3B9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">6-phospho-beta-glucosidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CG723_03380</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CB01635</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </cofactor>
        <text evidence="6">Binds 1 NAD(+) per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the glycosyl hydrolase 4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000001">
        <property type="protein sequence ID" value="PJN13609.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN13609">
        <property type="protein sequence ID" value="PJN13609"/>
        <property type="gene ID" value="CG723_03380"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019802">
        <property type="entry name" value="GlycHydrolase_4_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001088">
        <property type="entry name" value="Glyco_hydro_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022616">
        <property type="entry name" value="Glyco_hydro_4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015955">
        <property type="entry name" value="Lactate_DH/Glyco_Ohase_4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32092">
        <property type="entry name" value="PTHR32092"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02056">
        <property type="entry name" value="Glyco_hydro_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11975">
        <property type="entry name" value="Glyco_hydro_4C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00732">
        <property type="entry name" value="GLHYDRLASE4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56327">
        <property type="entry name" value="SSF56327"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01324">
        <property type="entry name" value="GLYCOSYL_HYDROL_F4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0464">Manganese</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0520">NAD</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glyco_hydro_4C" evidence="7">
        <location>
            <begin position="190"/>
            <end position="417"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF11975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PJN13609.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="442" mass="47251" checksum="B0E65286E852915C" modified="2018-04-25" version="1">MRLTILGGGGFRVPLVYGALLGDHAPGRVTEVTLHDTDPDRLRAVTGVLTEQATGVPDAPAVHATTDLDEALRGADFVFSAIRVGGLAGRAADERVALAEGVLGQETVGAGGIAYGLRTVPVAVDIARRVRQLAPDAWVINFTNPAGLVTEAMSRHLGDRVIGICDSPVGLGRRVARVLGADPGEAWIDYVGLNHLGWLRGLEVNGRDELPRLLADEKLLGSFEEGRLFGTDWLRSLGAIPNEYLHYYYFNRETVRAYQEADRTRGAFLLDQQAAFYADPSYASWDRTRAEREATYMAHNREASGAGERDAADLEESGGYEKVALALMRAIARDERATLILNVRGRGALPSLDDDAVVEIPCLVDANGAHPVSVAPLPGHATGLVSSVKAVEREVLEAAEGGSRAAAVKAFALHPLVDSVTVARRLLEGYASAHPGLAYLTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K3K7</accession>
    <name>A0A2M9K3K7_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 6">Isopentenyl-diphosphate Delta-isomerase</fullName>
            <shortName evidence="6">IPP isomerase</shortName>
            <ecNumber evidence="3 6">5.3.3.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">IPP:DMAPP isomerase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Isopentenyl pyrophosphate isomerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">idi</name>
        <name evidence="9" type="ORF">CG723_03695</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CB01635</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>isopentenyl diphosphate = dimethylallyl diphosphate</text>
            <dbReference type="Rhea" id="RHEA:23284"/>
            <dbReference type="ChEBI" id="CHEBI:57623"/>
            <dbReference type="ChEBI" id="CHEBI:128769"/>
            <dbReference type="EC" id="5.3.3.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="6">Binds 1 Mg(2+) ion per subunit. The magnesium ion binds only when substrate is bound.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="6">Binds 1 Mn(2+) ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 6">Isoprenoid biosynthesis; dimethylallyl diphosphate biosynthesis; dimethylallyl diphosphate from isopentenyl diphosphate: step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the IPP isomerase type 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.3.3.2" evidence="3 6"/>
    <dbReference type="EMBL" id="NNBL01000001">
        <property type="protein sequence ID" value="PJN13660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN13660">
        <property type="protein sequence ID" value="PJN13660"/>
        <property type="gene ID" value="CG723_03695"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00059">
        <property type="reaction ID" value="UER00104"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004452">
        <property type="term" value="F:isopentenyl-diphosphate delta-isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050992">
        <property type="term" value="P:dimethylallyl diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008299">
        <property type="term" value="P:isoprenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02885">
        <property type="entry name" value="IPP_Isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00202">
        <property type="entry name" value="Idi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011876">
        <property type="entry name" value="IsopentenylPP_isomerase_typ1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF018427">
        <property type="entry name" value="Isopntndiph_ism"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="SSF55811"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02150">
        <property type="entry name" value="IPP_isom_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 6 9" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4 6" id="KW-0414">Isoprene biosynthesis</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0464">Manganese</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="8">
        <location>
            <begin position="46"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="active site" evidence="6 7">
        <location>
            <position position="83"/>
        </location>
    </feature>
    <feature type="active site" evidence="6 7">
        <location>
            <position position="132"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="41"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="48"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="85"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="103"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="130"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="132"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007579"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR018427-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PJN13660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="197" mass="21138" checksum="ABEFDA5C9965CB54" modified="2018-04-25" version="1">MPTTPATAANSSSNGTGEAILLELVDEDGRTIGTAEKLSAHQAPGQLHRAFSVFLFDEQGRLLLQQRALGKYHSPGVWSNTCCGHPYPGEAPFAAAARRTFEELGVSPSLLAEAGTVRYNHPDPDSGLVEQEFNHLFVGMVQAPLRPDPSEVGETVYVTAEELAVRHAQGPFSAWFMTVLDAARPAIRELTGPSAGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K3N8</accession>
    <name>A0A2M9K3N8_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 8">Malto-oligosyltrehalose trehalohydrolase</fullName>
            <shortName evidence="8">MTHase</shortName>
            <ecNumber evidence="3 8">3.2.1.141</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7 8">4-alpha-D-((1-&gt;4)-alpha-D-glucano)trehalose trehalohydrolase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6 8">Maltooligosyl trehalose trehalohydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="primary">treZ</name>
        <name evidence="14" type="ORF">CG723_01465</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">CB01635</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1 8">Glycan biosynthesis; trehalose biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the glycosyl hydrolase 13 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.141" evidence="3 8"/>
    <dbReference type="EMBL" id="NNBL01000001">
        <property type="protein sequence ID" value="PJN13746.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN13746">
        <property type="protein sequence ID" value="PJN13746"/>
        <property type="gene ID" value="CG723_01465"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00299"/>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033942">
        <property type="term" value="F:4-alpha-D-(1-&gt;4)-alpha-D-glucanotrehalose trehalohydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005992">
        <property type="term" value="P:trehalose biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.760">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022567">
        <property type="entry name" value="DUF3459"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006047">
        <property type="entry name" value="Glyco_hydro_13_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012768">
        <property type="entry name" value="Trehalose_TreZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044901">
        <property type="entry name" value="Trehalose_TreZ_E-set_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00128">
        <property type="entry name" value="Alpha-amylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11941">
        <property type="entry name" value="DUF3459"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006337">
        <property type="entry name" value="Trehalose_TreZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00642">
        <property type="entry name" value="Aamy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="SSF81296"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02402">
        <property type="entry name" value="trehalose_TreZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5 8 14" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aamy" evidence="13">
        <location>
            <begin position="99"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="44"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="10">
        <location>
            <begin position="243"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="10">
        <location>
            <begin position="307"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="10">
        <location>
            <begin position="379"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="454"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="9">
        <location>
            <position position="245"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="9">
        <location>
            <position position="282"/>
        </location>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="11">
        <location>
            <position position="380"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015938"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00032057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00033284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR006337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR006337-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR006337-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR006337-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="PJN13746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="582" mass="63797" checksum="20B83E162278E451" modified="2018-04-25" version="1">MQFEVWAPQAERVALHCEGTTRALERDPDREGWWAGEADAQDGSRYGFALDDGPALPDPRSRRQPDGPEGLSAVVDHARYTWRSESGPGSGLPGAVLYELHVGTFTREGSLDAAAERLGDLVELGITHVALMPLCPFPGRHGWGYEGVSPWAVHEPYGGPEALKRFVDMAHGLGLGVVLDVVHNHLGPSGNHLPAFGPYFTDTHHTPWGAAVNLDAPGSDEVRAYFVGSALAWLRDYRIDGLRLDAVHALRDTRAVHYLEELSTAVDALAEEQDRTLFLVGESDLGDPRVITPRSHGGLGLQAQWSDDFHHALHTAVTGESQGYYEDFAKAPMAALAKTLSRGYFHDGTYSTFRGRHHGRPIDRTRTPAHRLLGYAQTHDQIGNRAQGDRLSASLSPGLLACAATLVLTAPFTPMLFMGEEWAAGTPWQFFTDHTDPALADAVRKGRRREFASHGWAEEDIPDPQDPATRERSCLDWSEPDSDSHARVLAWYRELIALRRARADLMDSDLAAVRVAYDEEARWIAYRRGDLRVAVNLSDEPAAVPVGRNGYRVLAAWEPVGLPGEDGLLTVPPRSCAVLVGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K3R5</accession>
    <name>A0A2M9K3R5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">ABC transporter substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CG723_02470</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000001">
        <property type="protein sequence ID" value="PJN13771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN13771">
        <property type="protein sequence ID" value="PJN13771"/>
        <property type="gene ID" value="CG723_02470"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001638">
        <property type="entry name" value="Solute-binding_3/MltF_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00497">
        <property type="entry name" value="SBP_bac_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00062">
        <property type="entry name" value="PBPb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014767339" evidence="2">
        <location>
            <begin position="26"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="domain" description="PBPb" evidence="3">
        <location>
            <begin position="65"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PJN13771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="305" mass="32951" checksum="0FA78A56ED0B6AEC" modified="2018-04-25" version="1">MLRKTRVFRAVAALALTALAAVACGKEGSPPAKGPSDAQLPKYQVAKGFELTDSKTWRKAKKRGHFVVGAKEDQPYLGEKDPATGVYSGFDIEIAKMISASLGFAPSSVAFRTIASANRETALQNGQIDYYVGTYTINDNRKKLVGFGGPYYMAGQSLLVRTDEHDINGPQDLDGKRVCSAAGSTPYQRIQKDYPKAVLVAYDTYSVCVDNLLTYQVDAVTTDDAILLGFAAKAPDELKLVGKPFSKEPYGIGVPRSDNALRFAIDTALQTRENDGDWKKAYDATLGLSGVPAPKPPPIDRYPAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JEW2</accession>
    <name>A0A2M9JEW2_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">VOC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_45015</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000049">
        <property type="protein sequence ID" value="PJN05424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN05424">
        <property type="protein sequence ID" value="PJN05424"/>
        <property type="gene ID" value="CG723_45015"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VOC" evidence="1">
        <location>
            <begin position="1"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN05424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="122" mass="13318" checksum="11EBE715CCA3206E" modified="2018-04-25" version="1">MGANTEQITDLKFSTAELHGEKVGFSARYGFLRTGSSEIELIQPLDGRSPYTEFLDLRGEGVHHLAYVVGSIDQYLESLRATGEAGRVTFEATIAGQTRFVYLDGLAHGPAIELIERIGEDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JEX8</accession>
    <name>A0A2M9JEX8_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Acyl-CoA_dh_1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_44520</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000048">
        <property type="protein sequence ID" value="PJN05429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN05429">
        <property type="protein sequence ID" value="PJN05429"/>
        <property type="gene ID" value="CG723_44520"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016627">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="SSF47203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA_dh_1" evidence="1">
        <location>
            <begin position="3"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN05429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="92" mass="10179" checksum="31E9C90B0257C53C" modified="2018-04-25" version="1">MLYGRPNLAAVSLGIHEAVLDTTTSYLKGRPRYNGALSGLPVLRDRVGGMEAGFRAARILAYQAVHLLEAGLRDDQGKEVERRMRRPASRED</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JF14</accession>
    <name>A0A2M9JF14_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CG723_44825</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000048">
        <property type="protein sequence ID" value="PJN05464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN05464">
        <property type="protein sequence ID" value="PJN05464"/>
        <property type="gene ID" value="CG723_44825"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PJN05464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="193" mass="21058" checksum="763D40BC11FE3C1F" modified="2018-04-25" version="1">MLRLTPIDRSKSPLFDADHDPVRIADALRRSPHFATADADAGGDTVWFTTEDGINYTLTFKDAEPTNDDLLPEPVLTEAIAAAILNHPGFVTATADSPREDTITVQTRNLVRHLLVLDVDRDGGVIAQEDLSTPAVDVAFVADRLLASDPSDSERATAELLNYVAATWDKQDHPLREHAQAIARALPQQRSEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JFH8</accession>
    <name>A0A2M9JFH8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_43335</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000043">
        <property type="protein sequence ID" value="PJN05648.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN05648">
        <property type="protein sequence ID" value="PJN05648"/>
        <property type="gene ID" value="CG723_43335"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.274.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038500">
        <property type="entry name" value="Antitermination_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014767330" evidence="1">
        <location>
            <begin position="20"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN05648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="97" mass="10703" checksum="FA53ACA274073978" modified="2018-04-25" version="1">MTLILLASACLLAVTLGYASLCAGSPFGDCRKCKGFGFAMKTDRKGRPKRGKTCRRCKGHGKRIRVGRHLYNVWLRLYRDGTDTPTKQPAFKPAAKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JFX8</accession>
    <name>A0A2M9JFX8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CG723_42960</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000041">
        <property type="protein sequence ID" value="PJN05794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN05794">
        <property type="protein sequence ID" value="PJN05794"/>
        <property type="gene ID" value="CG723_42960"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="20"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="52"/>
            <end position="59"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PJN05794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="297" mass="32068" checksum="5AA454C494986ABB" modified="2018-04-25" version="1">MSDSNPSQSNKRRSNTVNRLSAENVTLGYDQRVIASELSVEIPDNSFTVIVGPNACGKSTLLRALSRMLKPSSGRVLLDGQAIQSMPAKKVARTLGLLPQSSIAPDGITVGDLVSRGRYPHQGLLRQWSSEDERIVQESMASTGVAELTDRFVDELSGGQRQRVWIAMALAQQTPLLLLDEPTTYLDIQHQIDVLDLCAELHEEQGRTLVAVLHDLNHAARYATHLIALRGGEVIAEGAPGDIVTADLVERLFGMKCQVIDDPETGTPLVVPAARKARKGLVRDAEVPAKAVAKAAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JG14</accession>
    <name>A0A2M9JG14_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">LytR_C domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CG723_43450</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000043">
        <property type="protein sequence ID" value="PJN05697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN05697">
        <property type="protein sequence ID" value="PJN05697"/>
        <property type="gene ID" value="CG723_43450"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027381">
        <property type="entry name" value="LytR/CpsA/Psr_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13399">
        <property type="entry name" value="LytR_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="24"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="domain" description="LytR_C" evidence="3">
        <location>
            <begin position="85"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="59"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PJN05697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="206" mass="21126" checksum="B02D0F8F1A9FCB97" modified="2018-04-25" version="1">MGGKYRITGDKYPRMRRSRGRSRIVLAVVASVVAVGLIGWGTLQLIDVFTGGGDKASAAGATGDCRTKTSASPSASPKILPKPGQVTVNVLNATPRSGLAKQTADELKKRGFAIGDVGNATKAYDKKVKGPGLLLGARAATDAALPVLGTQLAGAELKTDTRAKPAEVDLIIGTAFKQLTTKADADKALAALAKTSPTSATSKKHC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JG38</accession>
    <name>A0A2M9JG38_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CG723_42600</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000040">
        <property type="protein sequence ID" value="PJN05850.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN05850">
        <property type="protein sequence ID" value="PJN05850"/>
        <property type="gene ID" value="CG723_42600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2010.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010428">
        <property type="entry name" value="Zincin_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038555">
        <property type="entry name" value="Zincin_1_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06262">
        <property type="entry name" value="Zincin_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PJN05850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="140" mass="15967" checksum="26F7CA204795CC65" modified="2018-04-25" version="1">MPMRMVPYARTDRSIWRRVADNGRVLEMTREEFEELVAEALDRIPPELTRLMDNVAVFVEDEPAAGEPELLGLYEGTPLTDRGEWYAGVLPDRITIYRGPTLRMCESREDVVAETEITVVHEIAHHFGIDDARLHALGYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JG48</accession>
    <name>A0A2M9JG48_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Histidine kinase</fullName>
            <ecNumber evidence="3">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CG723_42225</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CB01635</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="3"/>
    <dbReference type="EMBL" id="NNBL01000039">
        <property type="protein sequence ID" value="PJN05859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN05859">
        <property type="protein sequence ID" value="PJN05859"/>
        <property type="gene ID" value="CG723_42225"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00672">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00304">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 11" id="KW-0418">Kinase</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="77"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="266"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="10">
        <location>
            <begin position="286"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="9">
        <location>
            <begin position="353"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="116"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="170"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="569"/>
            <end position="693"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PJN05859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="693" mass="73246" checksum="1A1720246778C14B" modified="2018-04-25" version="1">MSRDSAAPAPGGPGIRSGRPVGPKAGRGSVLRRVLDGGLLLQGGMKGSPVLRLFTRWVRRPLLPARRLWRRNIQLKIVVTTLLMSLGVVLLLGIVVIGSVRNGLLDAKVKASQSQAEGGFRAAKDKADTAAAGARDGATTDSRAPLTPNNWMSELVTQLSSGGQSAFDVVTLSPPGADSGDSVRGPRASGGVLDPSVPDDLRERVEKMTGASQEYTRIVYEDGKDSQPGLVIGKQMTDPKGHAYQLYYLFPLTQEEKSLGLVKGTLATAGLFVVVLLGAIAWLVVRQVVTPVRMAAGVAERLSAGRLQERMKVTGEDDIARLGEAFNKMAQNLHTKIQQLEDLSRMQRRFVSDVSHELRTPLTTVRMAADVIHDARVDFDPVTARSAELLADQLDRFESLLSDLLEISRFDAGAAALEAEPIDLREVVRRVVGGAEPLAEHKGTHVRIVGDQQPVVAEADARRVERVLRNLVVNAVEHGEGKDVVVRLAAAGGAVAVAVRDYGVGLKPGEATRVFSRFWRADPARARTTGGTGLGLSIALEDARLHGGWLQAWGEPGGGSQFRLTLPRTADEPLRGSPIPLEPEDSRRNRGLSEAGLPLGGGAGKLATVPAQAAGAPRMPSSVPAKEPAAPRYAVDPAALPGNGSRVVSRGDAAAPAARRQDTGSPERAWDEQAGPAEKTGGSGEGSGGGRAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JGJ1</accession>
    <name>A0A2M9JGJ1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_41850</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000037">
        <property type="protein sequence ID" value="PJN05994.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN05994">
        <property type="protein sequence ID" value="PJN05994"/>
        <property type="gene ID" value="CG723_41850"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011048">
        <property type="entry name" value="Haem_d1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019405">
        <property type="entry name" value="Lactonase_7-beta_prop"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10282">
        <property type="entry name" value="Lactonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51004">
        <property type="entry name" value="SSF51004"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="128"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="128"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN05994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="348" mass="36203" checksum="10421A52A170A4D6" modified="2018-04-25" version="1">MSVGDRQGGRAYIGSFTAAGGSGIVTASVHMDSGSLTVLSAVDTLPDPSYLALSPARDFLYAVSETAEGAVAAFRTGDGKPELAGRGVPVRGSGPTHLALYDGHVLTANYGSGSVTSVRLRADGTLDGDSADVLRHEGSGTHPKRQQGPHAHQVAPDPSGRWAVSVDLGTDSVRVCSMKGGSLDVHREVALRPGSGPRHLAFHPRGDRAYILNELTPTVTVCQWDAAEGALQPLGEISVLPDAPHGDAFPSEVVVAPDGRFLWTATRGANVISVLALDATGDRPTLRATVSCGGDWPRDLALHPSGRFLYAANERSGDVTWFSVDRETGLPRRGGSIEAPAASCVIFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JGP9</accession>
    <name>A0A2M9JGP9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CG723_41240</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CB01635</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000036">
        <property type="protein sequence ID" value="PJN06033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN06033">
        <property type="protein sequence ID" value="PJN06033"/>
        <property type="gene ID" value="CG723_41240"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032808">
        <property type="entry name" value="DoxX"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13564">
        <property type="entry name" value="DoxX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="45"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="68"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="99"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PJN06033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="119" mass="12683" checksum="6B4E845A6D7A4FB9" modified="2018-04-25" version="1">MNIAYWIVAGLLALFYFYAGTLKVIRSRDQLRPMMAWVDRIPLPALRALGAVEILGATGLILPKLTGIAPSLATAAAIGFVLLQTGAIAVHLMGEDRRISLNAGLTVATAVAIWLATRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-06-02" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JGU0</accession>
    <name>A0A2M9JGU0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_40850</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000035">
        <property type="protein sequence ID" value="PJN06100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN06100">
        <property type="protein sequence ID" value="PJN06100"/>
        <property type="gene ID" value="CG723_40850"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN06100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="104" mass="11125" checksum="2664ED06A1703B2A" modified="2018-04-25" version="1">MAAHQNTQQEEIPSLPSSGILAGQPRPAPRTLPGAVQLAALTVAAHPRPDGAGSADPDLLMHLYDQTPQQLTHLLDRPARAHPPASWHPAPQEAEVVWQLPCSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JGV4</accession>
    <name>A0A2M9JGV4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CG723_40945</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000035">
        <property type="protein sequence ID" value="PJN06114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN06114">
        <property type="protein sequence ID" value="PJN06114"/>
        <property type="gene ID" value="CG723_40945"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036689">
        <property type="entry name" value="ESAT-6-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140453">
        <property type="entry name" value="SSF140453"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PJN06114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="448" mass="46970" checksum="1BB5EA9187696CE3" modified="2018-04-25" version="1">MPTYHDIMTVDLSTLTTAADRWDGMAKEFHKQEVAYDRDVHGISMGQAWTGLSADAANRRFDITLKEFQKAQTEAKAVASLLRDAHHQFSEVRKRLKSARADAIKARMAVSDEGVVSFDTTDLTEGERNALHHDPSYQESVGTAVTAWQDHLDQIVKDAEKTDHSVQTALNAVVIDSKGNDGTLEGFNGDAKDHLKDYKAAGKGGKKSGGWKGDGDFKLDWWSPSFSASADPKYGKEGSVKAAFDLIHMTGKGSLTNGDWKLSGIGDAYAGIRSSANYGFSDKGISGKAEVSAGARALMEGRAEYGDWGGVYLRGDGFAGAEAGISGKVNKDEVGVSAKAFYGAKASIGGGVEAAGIGIGGNFEVGAGQGVEAKFGVKKDEHGVWKLSTGAFAAEVVGAGAGTEITFDPNKFGKTVDSAADAVGLGGAAETVGHGLKSTKDTVAGWLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JH54</accession>
    <name>A0A2M9JH54_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CG723_40780</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000034">
        <property type="protein sequence ID" value="PJN06210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN06210">
        <property type="protein sequence ID" value="PJN06210"/>
        <property type="gene ID" value="CG723_40780"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025361">
        <property type="entry name" value="DUF4265"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14085">
        <property type="entry name" value="DUF4265"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PJN06210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="148" mass="16399" checksum="A68E791794FBDD9D" modified="2018-04-25" version="1">MDIDEDGWPPASVESLWAVDLGDSTVRLDNTPWFVRGVASGDVIRVQPDDDGVLWAGETVQPSQNCTIRLIVLQDDGSAAARQSVLEVFQRLGTTGEGIEQFRMVALDVPPQSDLPKIRELLEHGETKEWWHWEEGCVTAAWEAAARS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-09-29" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JHD4</accession>
    <name>A0A2M9JHD4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Beta-ACP synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CG723_40380</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CB01635</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000033">
        <property type="protein sequence ID" value="PJN06275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN06275">
        <property type="protein sequence ID" value="PJN06275"/>
        <property type="gene ID" value="CG723_40380"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004315">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00834">
        <property type="entry name" value="KAS_I_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000794">
        <property type="entry name" value="Beta-ketoacyl_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018201">
        <property type="entry name" value="Ketoacyl_synth_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11712">
        <property type="entry name" value="PTHR11712"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02801">
        <property type="entry name" value="Ketoacyl-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00825">
        <property type="entry name" value="PKS_KS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00606">
        <property type="entry name" value="B_KETOACYL_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PKS_KS" evidence="4">
        <location>
            <begin position="5"/>
            <end position="413"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PJN06275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="422" mass="44547" checksum="DC548B703219E91B" modified="2018-04-25" version="1">MTRRVAVTGVGVVAPGGIGASAFWDLLANGRTATRGITLFDPVGLRSRIAAECDLDPLAHGLDPELVEHADRYIQFAVIAAGEAVKDSGIDTGVEDPWRIGVSLGSAIGGTTRLEQDYVRVSEGGKRWDVDHRAAEPKLHMAFSPSTLASVVAEQFGAQGPVQTVSTGCTSGLDAVGYAFHTIEEGRADICIAGASDSPISPITMACFDAIKATSPNNDDPEHASRPFDAERNGFVMGEGAAVLVLEDYEHARARGAHIYCELSGYATYGNAYHMTGLTSEGLEMARAIDNALGQARLDPTLIDYVNAHGSGTRQNDRHETAAVKVSLGAHAYETPMSSIKSMVGHSLGAIGAIEVVACVLAMKHQVVPPTANYETPDPECDLDYVPRTARPRKLRNVLSVGSGFGGFQSAVLLTETGGRTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-09-29" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JHH6</accession>
    <name>A0A2M9JHH6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CG723_39430</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CB01635</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000031">
        <property type="protein sequence ID" value="PJN06339.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN06339">
        <property type="protein sequence ID" value="PJN06339"/>
        <property type="gene ID" value="CG723_39430"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="34"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="74"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="100"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="125"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="158"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="186"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="230"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="267"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="294"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="318"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="358"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="383"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="7">
        <location>
            <begin position="34"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PJN06339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="415" mass="42378" checksum="27C7FF9501FB4F0B" modified="2018-04-25" version="1">MNGTDVTRTEPTDRSPATPAVIGPAHKHKLPLPALLALATAVFVTSLTETLPAGLLPAMSRDLGVGESATGQTVTVYAIGTALTAIPLTAATAGWRRKRLLMTAMAGFGVANTVTAVSTNFPLTMAARFGAGVAAGLAWALLAGYARRLAPAHLQGRAIAIAMAGIPVALSLGVPAGTFLGKAVNWQSAFLSMTVLTVALLGWIAAAVPDRPGLRQEARPPILRALRVPGVPPVLFVTLVFVLAHTVLYTFVATFLDGVGMGNSTDLVLLAFGAASLASIWIVGVLINRHLRALTVTAALLVAVAAAVLALLSDSPALVYAAVTLWGLGWGGAPTLLQTAAGDAGGESADAAQAMLVTLWNVAMAGGGMAGGILLDLAGSRSFPWTVLLLLIPVLAVVVAARRHGFPVRRTARTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JHJ3</accession>
    <name>A0A2M9JHJ3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Anti-anti-sigma factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_39465</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000031">
        <property type="protein sequence ID" value="PJN06345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN06345">
        <property type="protein sequence ID" value="PJN06345"/>
        <property type="gene ID" value="CG723_39465"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.750.24">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002645">
        <property type="entry name" value="STAS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036513">
        <property type="entry name" value="STAS_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01740">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52091">
        <property type="entry name" value="SSF52091"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50801">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="STAS" evidence="2">
        <location>
            <begin position="9"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="115"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="121"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN06345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="150" mass="15924" checksum="06418751FC590C87" modified="2018-04-25" version="1">MSTQSHRLMITELASCDGCAVLRVSGELDQSAEGLFLGTLGACVDAGHPYLVLDVTALSFCDSRGLYCLLAMRWLLDRRGGKLLLAGAGRRLTELLTQTGSVDLLPAQRSVGQALSSLPPTHRPVWPPVPSPDALDDGSPSPPRPRPPTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JHL3</accession>
    <name>A0A2M9JHL3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DUF4865 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CG723_40225</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000033">
        <property type="protein sequence ID" value="PJN06247.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN06247">
        <property type="protein sequence ID" value="PJN06247"/>
        <property type="gene ID" value="CG723_40225"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032349">
        <property type="entry name" value="DUF4865"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16157">
        <property type="entry name" value="DUF4865"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PJN06247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="194" mass="21609" checksum="D2D69F66B290C57C" modified="2018-04-25" version="1">MHAMQYEITLPADYDMAIIRKRVETRGHLLDDFPGLGLKAYLMRERGVAGSPVNQYAPCYLWNTPQGMNSFLWGPGFQGIVDDFGRPEVQHWAGLAYEECPASHATPRSAVRRRTPLTGQAPLAEVTDAAVRDAARVAGQDGAVCAAVAVDPRRWELLTFSLWDHASPDTPGDLYEVLHLSAPERDRLPRGRQW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JIA6</accession>
    <name>A0A2M9JIA6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_38545</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000028">
        <property type="protein sequence ID" value="PJN06600.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN06600">
        <property type="protein sequence ID" value="PJN06600"/>
        <property type="gene ID" value="CG723_38545"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="16"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="113"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN06600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="138" mass="14457" checksum="E75536294CECA200" modified="2018-04-25" version="1">MATSGAKSGRFGGLDQWWGVLAGALLIAAWINSAAGPTVIITLSAAVLVWCFFQAPVTCGAPVRGRADGCRNNASGLLLGCHIHQHRWQKLKMLILRRQVRAFCSGLFSDGKAAIVTLAGVGSFISGLAALVPDVIIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JIC7</accession>
    <name>A0A2M9JIC7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycosyl transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_37815</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000027">
        <property type="protein sequence ID" value="PJN06645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN06645">
        <property type="protein sequence ID" value="PJN06645"/>
        <property type="gene ID" value="CG723_37815"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_2-like" evidence="2">
        <location>
            <begin position="27"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="246"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="250"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN06645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="265" mass="28979" checksum="D5F46610D3827101" modified="2018-04-25" version="1">MSSFVRPAIAGQYRAISTHLAIAPPVSVVIPAMNEAENLPYVFKTLPDWIHEVVLVDGNSTDNTVEVARELWPDVVVVPQRGKGKGDALIAGFAACTGDIIVMVDADGSADGQEIVSYVSALVSGADFAKGSRFANGGGTDDMTPIRKLGNWALCTVVNKKFGARYTDLCYGYNAFWRHCLDQIDLDCTGFEVETLMNIRVVKAGLKVQEIPSHEYLRIHGASNLRAVRDGLRVLKVILRERSTRRAQRRRTQASMLNTGRGEVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JIN9</accession>
    <name>A0A2M9JIN9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Two-component sensor histidine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CG723_37970</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000027">
        <property type="protein sequence ID" value="PJN06713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN06713">
        <property type="protein sequence ID" value="PJN06713"/>
        <property type="gene ID" value="CG723_37970"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011712">
        <property type="entry name" value="Sig_transdc_His_kin_sub3_dim/P"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07730">
        <property type="entry name" value="HisKA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="32"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="55"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="81"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="104"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="128"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="152"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="domain" description="HATPase_c" evidence="3">
        <location>
            <begin position="308"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PJN06713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="417" mass="43686" checksum="A5FB5EB8C709BA99" modified="2018-04-25" version="1">MPGADGAPTIPGVDATSTPPPPQRAYGTHRTVLTWIGAVLYPFMALLPAVSADPWAPGILPACGSALAAVLLVGMIRRRPMAALVMTLLVTALLPPVAKYHGPVWFVPFVAVDILLGYVVATRTLRASVVAVCLTFLTQCLTILGFTHGPDLLVIGTIALLALVTTCVVGLLGSERRRYANELRSHEVAEAITAERLRIARELHDQVAHSIGIIAIQAGVGSRVIETQPLEARAALSAIEATSRETLSGLRRTLVALRRSGPSAESGAAPYGPTPGLGDLERLATTTADAGVEVDLRWSGRRRQLPPDIDLSVYRIVQEALTNVVRHSGAGWCRVSVGFGEDGLSVEVVDEGRGMQGAGTGVGFGITGMRERVALLHGEFSAGPRPEGGFRVAARLPLPEPVATPTDGTSAAGADAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JIR6</accession>
    <name>A0A2M9JIR6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">3-oxoacyl-ACP reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CG723_37310</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000026">
        <property type="protein sequence ID" value="PJN06742.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN06742">
        <property type="protein sequence ID" value="PJN06742"/>
        <property type="gene ID" value="CG723_37310"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PJN06742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="437" mass="44898" checksum="B822592E9352AEF6" modified="2018-04-25" version="1">MADRYLNFTGTAPGRFLTRRLGLPQPAQLHRWTPERPALDGPLLHLTAGESVHTAELAGLLARTGLDVRAAAERPAAIVLDATAVTDVPTLAEVQAALHPVARSVASSGRIVVLGAPLSRDDHHQAATQQALEGFVRSLGKETGRGRTVTLVRVEGPVAAAESTLRFLLSPKSAYVSGQVIEVAAGETTAPADWARPLAGRTALITGAARGIGEAVAEVLARDGARLILLDVPSAQADLEALAARLDATALPLDITSPDAAERIADAVPALDTLVHNAGITRDRTLAKMPADRWATVLDVNLASVLTTTDALLKSGTLSHGGRIVATASIAGLAGNAGQTNYAASKAGIAGLTRALAPKALAEHGVTVNAVAPGFIETKMTAAVPLFIREAGRRMNSLGQGGLPVDVAETTAWFAHPASGAVNGQVVRVCGQSLLGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JJ42</accession>
    <name>A0A2M9JJ42_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">3-methyladenine DNA glycosylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CG723_37090</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000025">
        <property type="protein sequence ID" value="PJN06895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN06895">
        <property type="protein sequence ID" value="PJN06895"/>
        <property type="gene ID" value="CG723_37090"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011257">
        <property type="entry name" value="DNA_glycosylase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48150">
        <property type="entry name" value="SSF48150"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PJN06895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="336" mass="36915" checksum="0F6DB673BB55D972" modified="2018-04-25" version="1">MAGRYAPRPTRTTVRGGETVVPRAVLPRPATAAQTRRWTPKGAFDLGLTLGPLRRGPADPAFRVTPDGSVWRATRTPEGPGTLRVALRGTVAEADAWGPGATWLLAQLPQLLGELDEPEVFEPRHRLVAHAHHHRPGLRLLRTGLVMESLIPSILEQKITTEEAYRAWRILLRTYGTPAPGPTAGLGLHVMPEPRTWSLIPSWEWHRAGVDNKRASTILRAVKVARRMEEAAAMTPADARARLELIPGIGPWTSAETVQRSNGAADAVTTGDVHLPGIVGYALAGNRDADDAEMLRLLAPYEEQGQRHRAARLILLSGRTPPRRQPKMRRTNIADW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JJC9</accession>
    <name>A0A2M9JJC9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">LytR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CG723_37050</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CB01635</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LytR/CpsA/Psr (LCP) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000025">
        <property type="protein sequence ID" value="PJN06887.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN06887">
        <property type="protein sequence ID" value="PJN06887"/>
        <property type="gene ID" value="CG723_37050"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027381">
        <property type="entry name" value="LytR/CpsA/Psr_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004474">
        <property type="entry name" value="LytR_CpsA_psr"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13399">
        <property type="entry name" value="LytR_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03816">
        <property type="entry name" value="LytR_cpsA_psr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00350">
        <property type="entry name" value="lytR_cpsA_psr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014857720" evidence="2">
        <location>
            <begin position="21"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="domain" description="LytR_cpsA_psr" evidence="3">
        <location>
            <begin position="79"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="domain" description="LytR_C" evidence="4">
        <location>
            <begin position="340"/>
            <end position="426"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PJN06887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="453" mass="48545" checksum="0DA1C315C637F6DA" modified="2018-04-25" version="1">MRVATTVSVTVLAAAGIGHAVVTGLDTDINRIDPFKDMKNRPSGGHGMNVLLVGTDGRDKITPAERKKYRLGGAPCHCTDTIMIVHLSADKDRASIVSLPRDSYAEIPPHTDRTTGEQHQQHPVKINAAYAEGGPHLTVRTVEHMTGVKIDHYMEVDFTSFMKTVDVLGGVEICTAHPLKDSYTGLDMAVGTHTLDGGQALQYVRARHTDGAGDLGRMQRQQRFLAALIAKATSSGVLLNPVKFRDVIHTLLSSVRADKGFGTDQMVGLGQAMRGFSPSSSEFTTVPISQASFPVKGIGSTVKWDPAKSTKLFKALREDKPLAVHHRKKKETVVGVAPQQIRVQVENGTMTPGLGRKVDAGLRGTGFRTSGTPMNAAQRTAQHTVILYDPRWDQSAKALATALPGAQLQAVKGQGALLKVLAGPDFRAVRAVRAEDSRQGEFGAVTGDQVVCG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JJG9</accession>
    <name>A0A2M9JJG9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Ferric reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CG723_36090</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CB01635</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000024">
        <property type="protein sequence ID" value="PJN06927.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN06927">
        <property type="protein sequence ID" value="PJN06927"/>
        <property type="gene ID" value="CG723_36090"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013130">
        <property type="entry name" value="Fe3_Rdtase_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001433">
        <property type="entry name" value="OxRdtase_FAD/NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000951">
        <property type="entry name" value="Ph_dOase_redase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01794">
        <property type="entry name" value="Ferric_reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00175">
        <property type="entry name" value="NAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00409">
        <property type="entry name" value="PHDIOXRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="SSF52343"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="SSF63380"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="24"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="57"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="101"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="143"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="173"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="205"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding FR-type" evidence="8">
        <location>
            <begin position="231"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PJN06927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="454" mass="49456" checksum="921A79060DF93315" modified="2018-04-25" version="1">MTTTFDTTTHTSGGMRHRRPRRSVVPTLVPLVIWAGAAGVLALWWSDTNSVVGPAGWLTGAGRITGLLAGYACAVLLALMARVPLLDHTIGTDRLARWHALGGRCTISLMLAHTLLIVWGYSLTSHTDVVSQTSTLVLNYPDLLKGTVGFLLFVATGVLSARAARRRVSYETWHYLHFATYLAVFLTFGHQLSNGADFVGNRTAQAAWYTLFLSVAALVAWYRFAVPVRRGLRHRLRVAAVQPEAPGVVSVHLTGEHLNEMGAEPGQFLRWRFLARGLWWTANPYSLSAPPHPRHLRITVKKAGGHSAALARLAPGTRVWAEGPYGGFTARRRTAPKVLLLAGGVGITPLRALFETLPGEVTLVYRARRSDDLALRAELDAIAAHRRATVRYVVDEPAGFSSPLTARGLVALVPDLAAHDVYLCGPPGMTRVAIPALRQAGVPARRIHHESFEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JJH4</accession>
    <name>A0A2M9JJH4_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Anti-sigma factor antagonist</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CG723_35405</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CB01635</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the anti-sigma-factor antagonist family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000023">
        <property type="protein sequence ID" value="PJN07026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003975386.1">
        <property type="nucleotide sequence ID" value="NZ_NNBL01000023.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A2M9JJH4"/>
    <dbReference type="EnsemblBacteria" id="PJN07026">
        <property type="protein sequence ID" value="PJN07026"/>
        <property type="gene ID" value="CG723_35405"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043856">
        <property type="term" value="F:anti-sigma factor antagonist activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.750.24">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003658">
        <property type="entry name" value="Anti-sigma_ant"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002645">
        <property type="entry name" value="STAS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036513">
        <property type="entry name" value="STAS_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01740">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52091">
        <property type="entry name" value="SSF52091"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00377">
        <property type="entry name" value="ant_ant_sig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50801">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="STAS" evidence="3">
        <location>
            <begin position="3"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PJN07026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="113" mass="12321" checksum="DE2708636F8C9B24" modified="2018-04-25" version="1">MDLSLSTRTVGDRTVVEVGGEIDVYTAPKLREQLVELVNDGSFHLVVDMEGVDFLDSTGLGVLVGGLKRVRAHEGSLRLVCNQERILKIFRITGLTKVFPIHTSVEEAVAATD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-09-29" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JJH6</accession>
    <name>A0A2M9JJH6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_36025</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000024">
        <property type="protein sequence ID" value="PJN07013.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN07013">
        <property type="protein sequence ID" value="PJN07013"/>
        <property type="gene ID" value="CG723_36025"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019405">
        <property type="entry name" value="Lactonase_7-beta_prop"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011045">
        <property type="entry name" value="N2O_reductase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011964">
        <property type="entry name" value="YVTN_b-propeller_repeat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10282">
        <property type="entry name" value="Lactonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50974">
        <property type="entry name" value="SSF50974"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02276">
        <property type="entry name" value="beta_rpt_yvtn"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014909412" evidence="1">
        <location>
            <begin position="48"/>
            <end position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN07013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="357" mass="35848" checksum="C9013AF02A5E9DD2" modified="2018-04-25" version="1">MHTGGEMFSALRSRASNGCRRPPRTAGPALAAAIGILLTSCTTAGSADTHAAATTPAPVGPGSGSDGRVYVTNQQDDTLSVIDARTYKVVATVKAGKAPEGVAVAPDGRHVYIANNGSAQVSVLDTRTNKITTTVPVEKSPTGVGLSPDGRSLYVANGGSNTVSVIDTRTNRVAARIPVGKSPVSVTFSRDGSTAYVANSGSGSLSVINTRTRKVTGNLAAGHSPVGVAVTPDGKSAYVADEVAARVLAVGTRTRKATAVPVGEGPFDVAIGPDGKSVYAAVLGPGQVSVIDTGNNRVSSTISVGPTGTDPFNIEVTHQAVYVTEQAAGTLTVIDPKSNKVVATVTVGSSPYGVAVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JJW1</accession>
    <name>A0A2M9JJW1_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Urease accessory protein UreF</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">ureF</name>
        <name evidence="4" type="ORF">CG723_34765</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CB01635</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Required for maturation of urease via the functional incorporation of the urease nickel metallocenter.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">UreD, UreF and UreG form a complex that acts as a GTP-hydrolysis-dependent molecular chaperone, activating the urease apoprotein by helping to assemble the nickel containing metallocenter of UreC. The UreE protein probably delivers the nickel.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the UreF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000022">
        <property type="protein sequence ID" value="PJN07160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN07160">
        <property type="protein sequence ID" value="PJN07160"/>
        <property type="gene ID" value="CG723_34765"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016151">
        <property type="term" value="F:nickel cation binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006807">
        <property type="term" value="P:nitrogen compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.4190.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01385">
        <property type="entry name" value="UreF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002639">
        <property type="entry name" value="UreF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038277">
        <property type="entry name" value="UreF_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01730">
        <property type="entry name" value="UreF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF009467">
        <property type="entry name" value="Ureas_acces_UreF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0143">Chaperone</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 3" id="KW-0996">Nickel insertion</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PJN07160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="224" mass="22614" checksum="714449FCCADD080B" modified="2018-04-25" version="1">MTRAALLVLADGRFPAGGHAHSGGAEAAVKAGRITGAASLEDFCRGRLHTTGLVSASLAAAAALGLDPVTLDEAADARTPSPALRTAARRLGRQLMRAARAAWPHPELDALARRFPKGAHQPVVLGLTARAAGLGAADAAYCSAYESVSGPATATVRLLSLDPFDATAGLARLADDIDRVATEAAEAAARAVTEGTDSLPAASAPLLEVGAEAHAAWAVRLFAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JKU3</accession>
    <name>A0A2M9JKU3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_34075</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000021">
        <property type="protein sequence ID" value="PJN07397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN07397">
        <property type="protein sequence ID" value="PJN07397"/>
        <property type="gene ID" value="CG723_34075"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="696"/>
            <end position="734"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN07397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="734" mass="79519" checksum="B5B52ED78D72453B" modified="2018-04-25" version="1">MRRELRPADRPEGSTPPGNLPLELNRFVGRADELAELTRAFEAARLVTVTGAGGVGKSRFAARAAAVAAGHLGCDAVRRVDLATVREPHLVEYALAAALELTDHTSRPQREVLLDHLGQRQLLLVIDGFEHLVGACAPLVTELLGAAPDLRILAVGRRPLSVEGERIFPLAPLGTADAAELFADRAAALLPGFALDDGNRTDVVEVCRRLDCLPLAVELAAGRLRALSSADLLGRLDDRFRLLTGGTRGALPRHQTLRTAIGWSHELCTAQERLLWARLSVFSGQFDLDAAEYICSGDGLHAEAILDVLSELIAQSVVIREEADSVVRYRLLDTVRAYGADWLEVSGDTARMRRRHRDWYMGLATWCELDWFSPRQAQVAAQIGAELPNLRAALEFCLTEPGETHLGQYLAGTLWFFWAGCGRLSEGRHWLERSVGLDAESEDGDYSRSRLKALWVLGYVAILQGDTVPALAALQECRDEAERVGDATAVAYAEHRRGCLALVTDDLPRAEELLRTALAGYREIGELNSSVLMGQVELAMAVAFRGDLAAAVELCEDVRLICEDHGERWTLAYALYVLAYAEWTKGDLVRARQLLRECLVIGDTFHDLLGTVLTIELLALVTVTEGDAGEAALLQGAAGRIWPSVGLPLFGSAHYNAPHERCASDARAILGDARFESFVAAGARLEPGEAVQRALGRDAASRPAVVPGPRTAHPAPETREPAASPTVQSGETTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JL46</accession>
    <name>A0A2M9JL46_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Serine/threonine protein kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CG723_33980</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000020">
        <property type="protein sequence ID" value="PJN07497.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN07497">
        <property type="protein sequence ID" value="PJN07497"/>
        <property type="gene ID" value="CG723_33980"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="3">
        <location>
            <begin position="14"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="269"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="269"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="289"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="43"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PJN07497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="752" mass="83182" checksum="7F5FEC42B472084C" modified="2018-04-25" version="1">MPESGETRLIQGRYRLLDLIGRGGMGEVWRARDESLGRRVAVKCLKPMGPQHDQSFTRVLRERFRREARVAAALQHRGVTVVHDFGEHEGVLYLVMELLEGKNLSQLLEDNKQHPLPVADIVEIAGQVSSALAYTHEQGIVHRDLKPANIMRLADGTVKICDFGIARLGHDIGFTSRLTGTGIAMGTPHYMSPEQIGGDHVDQRSDLYSFGCVLYEIATGAPPFDLEDAWAVLVGHRDTVPEPPRRHRAELPGFLDRIIVDLLAKDPDERPRDARELARRIGDGRSRSGYVPTGSTTPLRQTAVEPQQPLSREPRLPSWTRGMTTGHKAAGPPLLRGTPPDAAAGLAGEWIARPESRRGEQPVRTERPTPAPESVAHLAARHNAGLSLGRLGRWEEAGEVHRAVAAEREHVLGPDHPETLASRYEVAFTLSRTGRPADALREYRRVTEGCERVLGPEHPETLGARQEMAYVLGQLGRHFDAHQVYTSVLAARERAMGPDHPDTLRCRHNLAYNLSRLGRLEDSYRMAREVASARARVLGASHPDTLVTRYEVAYALGQLGRWTEALRTYHEVAQTRGQALGPDHPDTLAARYEVGISLGRLGRSAEALGLYRDLIDDRTRVSGPAHPETLRTRHGLGVNLGRMGRWEEALAEARDVCAIRARVLGADHPDTLVSRREVAVGLGWLGRWSDALAEYRRVAAAREQVLGADHPDTLASRNDEAHCLEQLGRGTEAVELYRRVAALRQQRASGGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JL62</accession>
    <name>A0A2M9JL62_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GNAT family N-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_33160</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000019">
        <property type="protein sequence ID" value="PJN07616.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN07616">
        <property type="protein sequence ID" value="PJN07616"/>
        <property type="gene ID" value="CG723_33160"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="23"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN07616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="205" mass="22728" checksum="AD3B3C5C43F773F6" modified="2018-04-25" version="1">MGRRLVPLTLDNLPDLPKRCRSCVFWELDPVSGQAAIEAGTPELEKEAWISAVLLEWGSCGRVVYVDDVPVGFVLYAPPAYVPRSTAFPTSPVSPDAVQLMTAWIMPGYQGQGLGRVIVQTVAKDLLRRGFRAIEAFGDAQWKEPACMLPADHLLAVGFKTVRPHPSYPRLRLELRTTLSWKEDVELALDRLLGAVQKEPALRPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JLQ2</accession>
    <name>A0A2M9JLQ2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CG723_32510</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000018">
        <property type="protein sequence ID" value="PJN07789.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN07789">
        <property type="protein sequence ID" value="PJN07789"/>
        <property type="gene ID" value="CG723_32510"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="18"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="44"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="domain" description="HATPase_c" evidence="4">
        <location>
            <begin position="262"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="393"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="463"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="141"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="481"/>
            <end position="495"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PJN07789.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="540" mass="58587" checksum="6240A70B666943B8" modified="2018-04-25" version="1">MVSVQSPPGGREIPYTRVLLLPAVAMAAATGAAVAVVAQPARLAVALCGGLATLLLILVAAEAVRRGRTIKWERAQSARHVEHLERSLAARDDEAQWMARYLLPESLYRLRSGDTASEAVKVVVEADPAHSQLPDAQRRLMAEVLNVIDREENMRDAAQRAFVSIARRVQSIVHKQNAELREMEEDHGRNPEVFDDLLRIDHGTALIGRLADSITVLGGARPGRQWPRPVPLYSVLRGAMSRILEYPRIELHSIAKIAIRGISVEPLIHALAELMDNATRYSPPQTKVHVTAVEVQTGIAIEIEDGGVSLSEEARGRAEEMLARAKAGIDLNDLGENPRLGMAVVGRLSQMYDMQIALRQSAYGGVRAVLIVPRVMVTSDAAPGLAHGIGASGVPRVNNDGEPIVEEPRKKKLRRPTTGPRPSAPLVAAMEDDVPVVTEWRANGLPQRRRKVDTKVIDQQIIVTPRAPENGSGAAPRADQPPQWTPIPVPASEAEPEKPDQPEPGLWVEAFMNGLKGDGQGDASGKTGETNQQVDEGDRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JLV6</accession>
    <name>A0A2M9JLV6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_31110</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000017">
        <property type="protein sequence ID" value="PJN07854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN07854">
        <property type="protein sequence ID" value="PJN07854"/>
        <property type="gene ID" value="CG723_31110"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07228">
        <property type="entry name" value="SpoIIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00331">
        <property type="entry name" value="PP2C_SIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="SSF81606"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="26"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="51"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="96"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="domain" description="PPM-type phosphatase" evidence="2">
        <location>
            <begin position="149"/>
            <end position="376"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN07854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="383" mass="40699" checksum="EF179247F27E3AA3" modified="2018-04-25" version="1">MSTATIRTLAAGLSRACRRVAPHPLWLVGPLMVIVAVPVADAFLPADIHLAHLLVVATAVTAIGAGTRATTLICSVALLALVAAGVERHALTTESVLVELCALAAVSVLLVVFTHLRDRHERALVRARSVSDTAQRVVLRPLPERAGPVWLASEYHSSEADAYVGGDLYASARTSHSTRLIIGDVRGKGLASISDTAIVLGAFRSAAHRDIPLPELVAYVEDAVRWGLAEFSASEADLAERFVTAVMVDIPDDEPVVHVVSCGHPPPLLWRQSGATVTTLEVPEPAPPLGLALGDMPDSAYVPATFPFQEGDRLILYTDGVTEARDQRGDFYPLAERVAIWADQAPGTLVEAITADLEEYAGGRMNDDMAMVVAQRGRVPANA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JM24</accession>
    <name>A0A2M9JM24_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Lysophospholipase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CG723_31515</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000017">
        <property type="protein sequence ID" value="PJN07908.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN07908">
        <property type="protein sequence ID" value="PJN07908"/>
        <property type="gene ID" value="CG723_31515"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PJN07908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="235" mass="24978" checksum="DA3FE2DD803DFCD6" modified="2018-04-25" version="1">MPTSLSSWNEPEGLAARGTLIVLAGRGEHGGVYERFGRRLAFDAYRVRALGDPSADPSVLEEAAKLLADETLSGPKVLVGSDTGARYAAHLAAEQTPGIDALILAGLPTAPWVAGSWDAELEARTACPTHRGRLTNDPDFRRGSLDEASDLPELRLDLVRVPVLALHGAEDTVSPLDQALSAYAGFAGVRTVTFNSGRHDVLNDALHRTAAATVVLFLERLRLSAELPLIAEDLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JMC5</accession>
    <name>A0A2M9JMC5_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Phenolic acid decarboxylase</fullName>
            <shortName evidence="1">PAD</shortName>
            <ecNumber evidence="1">4.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_30405</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in the non-oxidative decarboxylation and detoxification of phenolic derivatives.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>prenyl-FMN</name>
            <dbReference type="ChEBI" id="CHEBI:87746"/>
        </cofactor>
        <text evidence="1">Binds 1 prenylated FMN (prenyl-FMN) per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the UbiD family. YclC subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.-" evidence="1"/>
    <dbReference type="EMBL" id="NNBL01000016">
        <property type="protein sequence ID" value="PJN08008.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08008">
        <property type="protein sequence ID" value="PJN08008"/>
        <property type="gene ID" value="CG723_30405"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016831">
        <property type="term" value="F:carboxy-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019439">
        <property type="term" value="P:aromatic compound catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009636">
        <property type="term" value="P:response to toxic substance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01985">
        <property type="entry name" value="UbiD_YclC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032902">
        <property type="entry name" value="BsdC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002830">
        <property type="entry name" value="UbiD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30108">
        <property type="entry name" value="PTHR30108"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01977">
        <property type="entry name" value="UbiD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00148">
        <property type="entry name" value="TIGR00148"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0058">Aromatic hydrocarbons catabolism</keyword>
    <keyword evidence="1" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="1" id="KW-0216">Detoxification</keyword>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="1" id="KW-0288">FMN</keyword>
    <keyword evidence="1" id="KW-0456">Lyase</keyword>
    <keyword evidence="1" id="KW-0464">Manganese</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Prenyl-FMN binding" evidence="1">
        <location>
            <begin position="161"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Prenyl-FMN binding" evidence="1">
        <location>
            <begin position="182"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="1">
        <location>
            <position position="274"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="161"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="183"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="225"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN08008.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="475" mass="52015" checksum="343F18E8A60BC220" modified="2018-04-25" version="1">MAYDDLRSFLDTLEKEGQLLRITDEVLPEPDLAAAANATGRIGENAPALHFDNVKGFTDARIAMNVHGSWANHALALGLPKNTPVKEQVEEFARRWDAFPVAPERREDAPWRENTQEGEDVDLFSVLPLFRLNDGDGGFYLDKAAVVSRDPDDPDDFGKQNVGTYRIQVIGTNRLAFQPVPMHDVAQHLRKAEEKGEDLPIAITLGNDPVMAIVAGMPMAYDQSEYEMAGALRGAPAPIATAPLTGFDVPWGSEVVIEGVIESRKRQIEGPFGEFTGHYSGGRRMPVIRVDRVSYRTNPVFESLYLGMPWTECDYLVGPNTCVPLLKQLRAEFPEVQAVNAMYTHGLMVIISTAKRYGGFAKAVGMRAMTTPHGLGYVAQVILVDEDVDPFNLPQVMWAMSAKVNPKDDVVVIPNLSVLELAPAAQPAGISSKMIIDATTPVAPDIRGNFSTPAKDLPETAEWAARLQRLIAARG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JN16</accession>
    <name>A0A2M9JN16_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ThiF domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_30050</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000015">
        <property type="protein sequence ID" value="PJN08245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08245">
        <property type="protein sequence ID" value="PJN08245"/>
        <property type="gene ID" value="CG723_30050"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008641">
        <property type="term" value="F:ubiquitin-like modifier activating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000594">
        <property type="entry name" value="ThiF_NAD_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035985">
        <property type="entry name" value="Ubiquitin-activating_enz"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00899">
        <property type="entry name" value="ThiF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69572">
        <property type="entry name" value="SSF69572"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ThiF" evidence="2">
        <location>
            <begin position="123"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="168"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="374"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="183"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="208"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN08245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="397" mass="41469" checksum="7FA0518266F434DD" modified="2018-04-25" version="1">MHPILKPALRRGWRDLNTVQFGVAAAHAVVLGPVDTATGTFLTLLDGTRGVALLRDEGRRMGLPDGHVDALLHRLTRAGLLDDATGGGPAFDALRKRQAVLDRLRPDLAALTILSPEPAAGARKLAARRSMRVQVRGTGRVGTVIASVLSAAGVGHVDVRDGGIVEPWDVAPGGLPVESVGERRDTAAYRAARKAAPDRPPRPDRRSGPPQSQAQPQAPSEVQAPPSAEEPALSLVIIAPRDGLSPHTPDPLAAEELIASGTPHLYAGVVEATGVVGPLVLPGGTACAGCLSLDRTDRDPTWPRLLAQWRSGRQLQVPACDLALATAVAGLTAAHALAFLDGELPSSTGARWEASAPGLDWHARPVWAHPDCSCGAGQRSKGEQTSEGGEQHDTMAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JN90</accession>
    <name>A0A2M9JN90_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DUF4177 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CG723_28200</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000014">
        <property type="protein sequence ID" value="PJN08287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08287">
        <property type="protein sequence ID" value="PJN08287"/>
        <property type="gene ID" value="CG723_28200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025234">
        <property type="entry name" value="DUF4177"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13783">
        <property type="entry name" value="DUF4177"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PJN08287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="52" mass="5906" checksum="C15DE0CF0EE24CD1" modified="2018-04-25" version="1">MTKWEYATVPLLVHATKQILDTWGEDGWELVQVVPGPNNPEQLVAYLKRAKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-09-29" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JNW1</accession>
    <name>A0A2M9JNW1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cyanamide hydratase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_27670</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000013">
        <property type="protein sequence ID" value="PJN08558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08558">
        <property type="protein sequence ID" value="PJN08558"/>
        <property type="gene ID" value="CG723_27670"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="SMART" id="SM00471">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HDc" evidence="1">
        <location>
            <begin position="25"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN08558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="202" mass="22074" checksum="511206C258E58302" modified="2018-04-25" version="1">MTLDDLLLPDTPVCTAATDVARAYCSPALLNHCVRSYIWAAAHGTEQDIAFDPELLYVGAMFHDIALVPEFDSHTVPFDDASAHVARVFAAGAGWSESRRERLAEVVISHMLDEVDVTKNPEGHLLERSTSLDISGRHMDDFSAAFKAEVLARHPRAGIAEEFLACFRDQAERKPGSSPATALRDGIAERILTNSLESLTRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JP49</accession>
    <name>A0A2M9JP49_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_26505</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000012">
        <property type="protein sequence ID" value="PJN08652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08652">
        <property type="protein sequence ID" value="PJN08652"/>
        <property type="gene ID" value="CG723_26505"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="29"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN08652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="62" mass="6590" checksum="EDEC3B68932FC1DD" modified="2018-04-25" version="1">MRHTVRRVLRGVERAGVRPSHALRTARIAGSGAASGATPGWLGLGTTRIPHKVPERDPDSVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JPF1</accession>
    <name>A0A2M9JPF1_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Purine nucleoside phosphorylase</fullName>
            <shortName evidence="1">PNP</shortName>
            <ecNumber evidence="1">2.4.2.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_27010</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Purine nucleoside phosphorylase involved in purine salvage.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a purine D-ribonucleoside + phosphate = a purine nucleobase + alpha-D-ribose 1-phosphate</text>
            <dbReference type="Rhea" id="RHEA:19805"/>
            <dbReference type="ChEBI" id="CHEBI:26386"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57720"/>
            <dbReference type="ChEBI" id="CHEBI:142355"/>
            <dbReference type="EC" id="2.4.2.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Purine metabolism; purine nucleoside salvage.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homohexamer. Dimer of a homotrimer.</text>
    </comment>
    <comment type="miscellaneous">
        <text evidence="1">Although this enzyme belongs to the family of MTA phosphorylases based on sequence homology, it lacks several conserved amino acids in the substrate binding pocket that confer specificity towards MTA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the PNP/MTAP phosphorylase family. MTAP subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.1" evidence="1"/>
    <dbReference type="EMBL" id="NNBL01000012">
        <property type="protein sequence ID" value="PJN08736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08736">
        <property type="protein sequence ID" value="PJN08736"/>
        <property type="gene ID" value="CG723_27010"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00606"/>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017061">
        <property type="term" value="F:S-methyl-5-thioadenosine phosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006166">
        <property type="term" value="P:purine ribonucleoside salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd09010">
        <property type="entry name" value="MTAP_SsMTAPII_like_MTIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1580">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01963">
        <property type="entry name" value="MTAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010044">
        <property type="entry name" value="MTAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000845">
        <property type="entry name" value="Nucleoside_phosphorylase_d"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035994">
        <property type="entry name" value="Nucleoside_phosphorylase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42679">
        <property type="entry name" value="PTHR42679"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01048">
        <property type="entry name" value="PNP_UDP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53167">
        <property type="entry name" value="SSF53167"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01694">
        <property type="entry name" value="MTAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="1" id="KW-0660">Purine salvage</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PNP_UDP_1" evidence="2">
        <location>
            <begin position="19"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="region of interest" description="Phosphate binding" evidence="1">
        <location>
            <begin position="66"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="1">
        <location>
            <begin position="229"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="26"/>
        </location>
        <ligand>
            <name>phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="205"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="206"/>
        </location>
        <ligand>
            <name>phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
        </ligand>
    </feature>
    <feature type="site" description="Important for substrate specificity" evidence="1">
        <location>
            <position position="187"/>
        </location>
    </feature>
    <feature type="site" description="Important for substrate specificity" evidence="1">
        <location>
            <position position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN08736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="291" mass="30946" checksum="FF7DCAB0FB060020" modified="2018-04-25" version="1">MANTVPGTANKANTQVTAEIGVIGGSGFYSFLDDVTEVQVDTPYGAPSDSLFLGEIAGRKVAFLPRHGRGHHLPPHRINYRANLWALRSVGVRQVLGPCAVGGLRPEFGPGTLLVPDQFVDRTKARAQTYFDGEPLADGSVPNVVHVSPADPYCPAGRRVAVKAARGRDWEPVDGGTLVVVEGPRFSTRAESRWHASQGWSVVGMTGHPEAMLARELELCYTSLTLVTDLDAGADSGEGVSHDEVLQVFAANVDRLRAVLFDAVAELPAEGERDCLCRGALGGMDPGIVLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-09-29" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JPT8</accession>
    <name>A0A2M9JPT8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Chitinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CG723_25625</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CB01635</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 18 family. Chitinase class II subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000011">
        <property type="protein sequence ID" value="PJN08876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08876">
        <property type="protein sequence ID" value="PJN08876"/>
        <property type="gene ID" value="CG723_25625"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030247">
        <property type="term" value="F:polysaccharide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.290">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001919">
        <property type="entry name" value="CBD2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008965">
        <property type="entry name" value="CBM2/CBM3_carb-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012291">
        <property type="entry name" value="CBM2_carb-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018366">
        <property type="entry name" value="CBM2_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011583">
        <property type="entry name" value="Chitinase_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029070">
        <property type="entry name" value="Chitinase_insertion_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001223">
        <property type="entry name" value="Glyco_hydro18_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001579">
        <property type="entry name" value="Glyco_hydro_18_chit_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00553">
        <property type="entry name" value="CBM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00041">
        <property type="entry name" value="fn3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00704">
        <property type="entry name" value="Glyco_hydro_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00637">
        <property type="entry name" value="CBD_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00636">
        <property type="entry name" value="Glyco_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="SSF49265"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49384">
        <property type="entry name" value="SSF49384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54556">
        <property type="entry name" value="SSF54556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51173">
        <property type="entry name" value="CBM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00561">
        <property type="entry name" value="CBM2_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01095">
        <property type="entry name" value="GH18_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51910">
        <property type="entry name" value="GH18_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="4 6" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CBM2" evidence="9">
        <location>
            <begin position="52"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="8">
        <location>
            <begin position="171"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="domain" description="GH18" evidence="10">
        <location>
            <begin position="265"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="237"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="237"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PJN08876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="633" mass="66060" checksum="1C730B38EA17A26F" modified="2018-04-25" version="1">MLTGGAGFHPRHVPRIPPEEHPLRLRLRQRAVAGLTTLLLPAAALVGLATPSHAAAAASTATATYVKTQDWGTGFEGKWTVKNTGTTALSSWTVEWDFPAGTKVTSAWDATVTNSADHWTAKNLTWNGSLAPGASVSFGFNGSGPGAPSGCKLNGASCDGGDVPGDAAPSAPGTPTASSVTNTSVKLDWTAATDDKGIKNYDVLRDGTKVATVTGTSYSDSGLTAGTDYSYTVQARDTADQSGPASGSVRVHTTGGGTDPGPGGKVKLGYFTDWGVYGRAYYPKNLETSGSAAKVTHINYAFGNVQNGQCTMGDSYADTDMAYTAANSVSGVADTWDQPLRGAINQLRQLKAKHPNLKILWSFGGWTWSGGFPQAAQNPAAFADSCYKLVEDPRWADVFDGIDIDWEYPNACGLSCDTSGQDALKKLASALRTKFGAGNLVTAAITADASTGGKIEKNDYAGASQSFDWYNVMTYDFFGAFNAQGPTAPHSPLTSYPGIPQQGFNSADAIAKLKAQGVPSSKLLLGIGFYGRGWTGVTQKEPGGTATGPAAGTYEQGIEDYKVLKTKCPANGTVAGTAYAYCGSDWWSYDTPATINSKMAWAKSQNLGGAFFWEFSGDTAGGELVTAIDSGLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JPU8</accession>
    <name>A0A2M9JPU8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Excisionase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_25780</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000011">
        <property type="protein sequence ID" value="PJN08902.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08902">
        <property type="protein sequence ID" value="PJN08902"/>
        <property type="gene ID" value="CG723_25780"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041657">
        <property type="entry name" value="HTH_17"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12728">
        <property type="entry name" value="HTH_17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="SSF46955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH_17" evidence="1">
        <location>
            <begin position="5"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN08902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="61" mass="7232" checksum="93B6D4515D5F5D3D" modified="2018-04-25" version="1">MRDVLMTVPEILDELGGISRRTFYRWRELGLVPVAFKLPNGELRVRRSDFQTWLRKLEEAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JQB5</accession>
    <name>A0A2M9JQB5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CG723_24315</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000010">
        <property type="protein sequence ID" value="PJN09058.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN09058">
        <property type="protein sequence ID" value="PJN09058"/>
        <property type="gene ID" value="CG723_24315"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="12"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="46"/>
            <end position="53"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PJN09058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="306" mass="31684" checksum="3B6E376A6B4041BC" modified="2018-04-25" version="1">MSSTSTTPAVAIEATGLGKRYGRHGHAALDLCSFRLPAGRISALVGPNGAGKSTLLAIAAGLLRPSSGHLTVLGAAPGVHRDRVAYLSQDKPLYPQLSIADTLRMGAELNPGHWDAAYADRIIEQGDLDPAARVRSLSGGQRTRVALALALGKRPQLMLLDEPMADLDPLARHELMGTLMADAAEHGTTILMSSHIVAELADACDHLLLLGAGRIRLGGGIDDLTAAHSLVTGRGSVADLAPHTVVESRAAGRGLTALIRRDGPLDSAWEAQEPSMEELILAHLRNPGAPALITPGTAASAVAVTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-05-25" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JQG2</accession>
    <name>A0A2M9JQG2_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Peptidase M20 domain-containing protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_24655</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M20A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000010">
        <property type="protein sequence ID" value="PJN09110.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN09110">
        <property type="protein sequence ID" value="PJN09110"/>
        <property type="gene ID" value="CG723_24655"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016805">
        <property type="term" value="F:dipeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017439">
        <property type="entry name" value="Amidohydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036264">
        <property type="entry name" value="Bact_exopeptidase_dim_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002933">
        <property type="entry name" value="Peptidase_M20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011650">
        <property type="entry name" value="Peptidase_M20_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017144">
        <property type="entry name" value="Xaa-Arg_dipeptidase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07687">
        <property type="entry name" value="M20_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01546">
        <property type="entry name" value="Peptidase_M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037226">
        <property type="entry name" value="Amidohydrolase_ACY1L2_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55031">
        <property type="entry name" value="SSF55031"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01891">
        <property type="entry name" value="amidohydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="M20_dimer" evidence="2">
        <location>
            <begin position="163"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRNR" id="PIRNR037226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN09110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="385" mass="40027" checksum="B7EFBE9D74C575E8" modified="2018-04-25" version="1">MRPVREAVAKAAPELLALSHRIHANPEVAWEEEKAARWTAYALDDLGYDVVTGTAGLPTAFTATVGSGPLHLAICAEYDALPGLGHACGHNVIAAAAVGAAAGLAPVADELGLKVTVFGTPAEEGGGGKILMLERGAFDGVHAAMMVHPGPADVAEAAPYAVAHLKVRFHGKAAHAAAYPEQGRNAADAFTVAQVAIGLLRQQLPSTTRVHGMVTRGGEAPNAIPELTEGRWYVRAGSLEELSALQPRVERCFEAGALASACDLEIEPESRPYSEFRNDAAMLAVYRRAAESLGRTFDSSGSPAARMNRASTDMGNVSRVLPAIHPYLGINSLPAVNHQKEFAAACVTPDADRAVLDGALGMALTAVALAGDDGERARLTAPGSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JQG8</accession>
    <name>A0A2M9JQG8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">CarD family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_24705</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000010">
        <property type="protein sequence ID" value="PJN09118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003953493.1">
        <property type="nucleotide sequence ID" value="NZ_NNBL01000010.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN09118">
        <property type="protein sequence ID" value="PJN09118"/>
        <property type="gene ID" value="CG723_24705"/>
    </dbReference>
    <dbReference type="GeneID" id="63981650"/>
    <dbReference type="GeneID" id="67401070"/>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1290">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036101">
        <property type="entry name" value="CarD-like/TRCF_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003711">
        <property type="entry name" value="CarD-like/TRCF_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042215">
        <property type="entry name" value="CarD-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02559">
        <property type="entry name" value="CarD_CdnL_TRCF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01058">
        <property type="entry name" value="CarD_TRCF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141259">
        <property type="entry name" value="SSF141259"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CarD_TRCF" evidence="1">
        <location>
            <begin position="2"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM01058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN09118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="160" mass="17829" checksum="0D8F10F093DB8DAB" modified="2018-04-25" version="1">MTFKVGDTVVYPHHGAALIEAIETRQIKGVDKTYLVLKVAQGDLTVRVPADNAEFVGVRDVVGQDGLDRVFEVLRAPYAEEPTNWSRRYKANLEKLASGDVIKVAEVVRDLWRRERERGLSAGEKRMLAKARQILVSELALAENTNEDKAEALLDEVLAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JR98</accession>
    <name>A0A2M9JR98_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_24115</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000009">
        <property type="protein sequence ID" value="PJN09410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN09410">
        <property type="protein sequence ID" value="PJN09410"/>
        <property type="gene ID" value="CG723_24115"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014747725" evidence="1">
        <location>
            <begin position="22"/>
            <end position="373"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN09410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="373" mass="39563" checksum="72DEDEC1E4CA9964" modified="2018-04-25" version="1">MTRSLQLMLLMGKVVPVPAPAVLVDALQSVQVTSSSGSASGFQLAFAVSKRSPLTEVMLPTGLLDPKTRVVVVAVVAGVPHVLMDGVITRQEINPGKAPGSSTLTLTGEDLSLLMDLRHVERCYPGLPHHLRVMLVCAGYAQYGIVPLAVPPAISSLPNPAVEVPVQSATDLAYLRALADEVGYVFFIEPGPAPGVSIAYWGPEVRAGLPQPALTVDSGTADNVESLSFSFDGLSHTQYTARFVEPIAKTQQTVPVPDVSLLHPPLALRPAPALREEPLTGQTGRSLAETLLWGLSRRAQSADAVTGQGKLDVLRYGHVLSARNLVGVRGAGLTYDGLYYVRSVTHDIARGAYKQSFTLTRDALVSNMPVVVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JRB8</accession>
    <name>A0A2M9JRB8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ABC transporter substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_24005</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000009">
        <property type="protein sequence ID" value="PJN09392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN09392">
        <property type="protein sequence ID" value="PJN09392"/>
        <property type="gene ID" value="CG723_24005"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006059">
        <property type="entry name" value="SBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01547">
        <property type="entry name" value="SBP_bac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014754213" evidence="1">
        <location>
            <begin position="24"/>
            <end position="441"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN09392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="441" mass="47679" checksum="8EBDE583FC5D8732" modified="2018-04-25" version="1">MSTSSRLLSRRSFGRLAAGIAGAAGTAALGACSPGAGKPSASAPLRIMAINHVWSQAIKRRTKEFEERIGRRVSLTLLTADQLTSSYNVKLNASGTDVDVMMVRALQDQLLFAHNDWLADLTDRVEGDSEFAWTDFQKAPREVSVTAGKVLSVPVVTERPTLYYRKDLVQDAGGPPRTLDALMSSALELSRRKQGFYGYVGRGQRNGAVSQWSSFLYSHGGDFVIDGRSGIGTPQALAAYEYYGRLLGKAGPPGATNMSLEQAMPIFAQGKAAFYIDADAIYSNFLDPKIASRTVRDTVGFAPFPAGPAGARPHNIASWSLGINKFSLLRDDAWQFIKWAAGPDMSAALQADGIPGARTSVWADSKTLRSFPPDLAEAMSLNAKRGLGYDRPRVLQVGRARDIVGRPLVAGILGEPVRPVVRDADAEFADFLVRDNRHKES</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JRF7</accession>
    <name>A0A2M9JRF7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">RNA polymerase subunit sigma-70</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CG723_22090</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CB01635</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000008">
        <property type="protein sequence ID" value="PJN09466.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN09466">
        <property type="protein sequence ID" value="PJN09466"/>
        <property type="gene ID" value="CG723_22090"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050896">
        <property type="term" value="P:response to stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039425">
        <property type="entry name" value="RNA_pol_sigma-70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013249">
        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43133">
        <property type="entry name" value="PTHR43133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08281">
        <property type="entry name" value="Sigma70_r4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="6">
        <location>
            <begin position="53"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4_2" evidence="7">
        <location>
            <begin position="150"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="122"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="11"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF08281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PJN09466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="210" mass="22828" checksum="9CBF4D92923EEDEA" modified="2018-04-25" version="1">MTHSAGPSPRRAACPGPPPDPPVPGTADGLLTAPDDLLATRAGEGDEEAFAILVRRHSRPLLALASHTLGNVQDAEDAVQDAFISAWRSLPEFRHASAFSTWMYRITVNRCLNSLRRRPAPVPLNSVAEPAAPGTRSSPARAAEQDALTEALVNALGALEPQQRVCWILRELHGLPYEQIAHVTGTTEQTVRGRLYRARRSLKEALGPWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JRX0</accession>
    <name>A0A2M9JRX0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Threonine dehydratase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CG723_23045</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CB01635</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000008">
        <property type="protein sequence ID" value="PJN09608.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN09608">
        <property type="protein sequence ID" value="PJN09608"/>
        <property type="gene ID" value="CG723_23045"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901607">
        <property type="term" value="P:alpha-amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="PLP-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="Trypto_synt_PLP_dependent"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="SSF53686"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PALP" evidence="3">
        <location>
            <begin position="24"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PJN09608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="325" mass="34240" checksum="48BEDE960BA0E1F2" modified="2018-04-25" version="1">MQETRLDTTRIRAARRVIDPIFLDTPLYRCEALEPGLGCTVSIKLETANPVRSFKGRGTEVVASLLADNGSRDVVCASAGNLGQALAWSGRGRGLDVTVVASRFATVAKLDRIRALGARLELVDGDHEMARERAAAIARYDGIRLVEDSLDIETCEGAATIGLELVDTVPSFDAVLIALGGGALATGVGHVVKSLAPEVEVICVQPLGAPAMTHSWRGRRVVTTDSTDTIADGVAGRCPIPAVLDDLLLVADDAVLVQEASIIAGMRMLLDHAGLVVEPSAALGIAAVLEDRARFADRHVVTIVCGSNVDVDAYHRWVGGAPRTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JSP4</accession>
    <name>A0A2M9JSP4_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">STAS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_19300</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000006">
        <property type="protein sequence ID" value="PJN09890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN09890">
        <property type="protein sequence ID" value="PJN09890"/>
        <property type="gene ID" value="CG723_19300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.750.24">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002645">
        <property type="entry name" value="STAS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036513">
        <property type="entry name" value="STAS_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13466">
        <property type="entry name" value="STAS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52091">
        <property type="entry name" value="SSF52091"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50801">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="STAS" evidence="1">
        <location>
            <begin position="24"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN09890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="134" mass="14119" checksum="3A6FE14FE55E1978" modified="2018-04-25" version="1">MSSRRRAGLPGVAAFRPPDLAPAGPLRRGDVPHLCDQVRTACARAPARDIVCDLAAVTTADLASVDALARMQLAARRAGSGLRLRDPSPALWALLQLVGLPGLGGLVVEMERHAEQREIARCVQEAVESGDPAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JSX0</accession>
    <name>A0A2M9JSX0_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">GtrA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CG723_19620</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CB01635</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GtrA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000006">
        <property type="protein sequence ID" value="PJN09943.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN09943">
        <property type="protein sequence ID" value="PJN09943"/>
        <property type="gene ID" value="CG723_19620"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000271">
        <property type="term" value="P:polysaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007267">
        <property type="entry name" value="GtrA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04138">
        <property type="entry name" value="GtrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="7"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="43"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="74"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="109"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="domain" description="GtrA" evidence="7">
        <location>
            <begin position="11"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PJN09943.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="154" mass="16357" checksum="2E6188C8329179F8" modified="2018-04-25" version="1">MRSLGRELVGFAVVGSCAYVADLGIFVWLRGPVGWDPIAAKSLSFLAGCTAAYVGNALGTYRRAVVEVSRVRQYGVFFAVNVAGALVQLLCIAVSHYGLGLTSQRADTVSGAGVGMMLATALRFWGTRTLVFRAAIPARRARTVREGRLGSWTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-05-25" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JT44</accession>
    <name>A0A2M9JT44_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 3">50S ribosomal protein L24</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">rplX</name>
        <name evidence="6" type="ORF">CG723_20275</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CB01635</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit.</text>
    </comment>
    <comment type="function">
        <text evidence="3">One of two assembly initiator proteins, it binds directly to the 5'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Part of the 50S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 3 4">Belongs to the universal ribosomal protein uL24 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000006">
        <property type="protein sequence ID" value="PJN10055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN10055">
        <property type="protein sequence ID" value="PJN10055"/>
        <property type="gene ID" value="CG723_20275"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06089">
        <property type="entry name" value="KOW_RPL26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01326_B">
        <property type="entry name" value="Ribosomal_L24_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005824">
        <property type="entry name" value="KOW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041988">
        <property type="entry name" value="KOW_RPL26/RPL24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_L2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003256">
        <property type="entry name" value="Ribosomal_L24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005825">
        <property type="entry name" value="Ribosomal_L24/26_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12903">
        <property type="entry name" value="PTHR12903"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00467">
        <property type="entry name" value="KOW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17136">
        <property type="entry name" value="ribosomal_L24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00739">
        <property type="entry name" value="KOW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="SSF50104"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01079">
        <property type="entry name" value="rplX_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01108">
        <property type="entry name" value="RIBOSOMAL_L24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 4 6" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="KOW" evidence="5">
        <location>
            <begin position="2"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00029550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PJN10055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="107" mass="11507" checksum="9FC87552B962A0D8" modified="2018-04-25" version="1">MKIKKGDLVQVITGKDKGKQGKVIAAFPREDRVLVEGVNRVKKHTKAGPTASGSQAGGIVTTEAPVHVSNVQLVVEKDGNKVVTRVGYRFDDEGNKVRVAKRTGEDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JT80</accession>
    <name>A0A2M9JT80_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">UPF0336 protein CG723_20535</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_20535</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0336 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000006">
        <property type="protein sequence ID" value="PJN10096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN10096">
        <property type="protein sequence ID" value="PJN10096"/>
        <property type="gene ID" value="CG723_20535"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00799">
        <property type="entry name" value="UPF0336"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039569">
        <property type="entry name" value="MaoC-like_dehydrat_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016709">
        <property type="entry name" value="UPF0336"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13452">
        <property type="entry name" value="MaoC_dehydrat_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF018072">
        <property type="entry name" value="UCP018072"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="SSF54637"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MaoC_dehydrat_N" evidence="2">
        <location>
            <begin position="6"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00799"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN10096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="150" mass="16286" checksum="F1B0AAE3AD4CD575" modified="2018-04-25" version="1">MALDQSFVGRSYPPTDPYEVGREKIREFAEAVRDANPAYVDPEAAKALGHPDVIAPPTFVFAITFKAAGQVIEDPQLGLDYSRVVHGDQKFVYTRPVRAGDRLTVTSTIEAIKSLAGNDILDIRGEVHDETGEHVVTAHTKLVSRAAEGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JTJ5</accession>
    <name>A0A2M9JTJ5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_17555</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000005">
        <property type="protein sequence ID" value="PJN10205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN10205">
        <property type="protein sequence ID" value="PJN10205"/>
        <property type="gene ID" value="CG723_17555"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001845">
        <property type="entry name" value="HTH_ArsR_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00778">
        <property type="entry name" value="HTHARSR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00418">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50987">
        <property type="entry name" value="HTH_ARSR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH arsR-type" evidence="1">
        <location>
            <begin position="1"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN10205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="102" mass="11472" checksum="932AC74364F2CBAA" modified="2018-04-25" version="1">MADDLFKALADPTRRTILDELTEKSGQTLFEICGRLSMKHQLGISRQGVSQHLAVLEAAGLVETRREGRYKFHELNTEPLRHIAERWPVPAPHTSGPEESTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JTK4</accession>
    <name>A0A2M9JTK4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Deaminase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_17620</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000005">
        <property type="protein sequence ID" value="PJN10215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN10215">
        <property type="protein sequence ID" value="PJN10215"/>
        <property type="gene ID" value="CG723_17620"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008703">
        <property type="term" value="F:5-amino-6-(5-phosphoribosylamino)uracil reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009231">
        <property type="term" value="P:riboflavin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.430.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024072">
        <property type="entry name" value="DHFR-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002734">
        <property type="entry name" value="RibDG_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01872">
        <property type="entry name" value="RibD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53597">
        <property type="entry name" value="SSF53597"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RibD_C" evidence="1">
        <location>
            <begin position="3"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN10215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="187" mass="20446" checksum="EC1196D607536C7A" modified="2018-04-25" version="1">MQTLTVDVFVSVDGYAGSATSPAYFGYFGPMIEEWIHEEMAGPQLVLVGRRTYEALAGLPRESGGPGADPMPGVDKVVFSSTLKTVAWQNTRVCQEDLIAEVTRLKSEGHVPLRTMGSLSLARQLLDAGLVDRLRLMTFPLLVGESGREPFFAGVDSTELELVAHHDLDNRVLMIEYRPTGRAIPQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JU45</accession>
    <name>A0A2M9JU45_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7">Carbonic anhydrase</fullName>
            <ecNumber evidence="3 7">4.2.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Carbonate dehydratase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CG723_18405</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CB01635</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the reversible hydration of carbon dioxide to form bicarbonate.</text>
    </comment>
    <comment type="function">
        <text evidence="7">Reversible hydration of carbon dioxide.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>H(+) + hydrogencarbonate = CO2 + H2O</text>
            <dbReference type="Rhea" id="RHEA:10748"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="EC" id="4.2.1.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the beta-class carbonic anhydrase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.1" evidence="3 7"/>
    <dbReference type="EMBL" id="NNBL01000005">
        <property type="protein sequence ID" value="PJN10348.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN10348">
        <property type="protein sequence ID" value="PJN10348"/>
        <property type="gene ID" value="CG723_18405"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004089">
        <property type="term" value="F:carbonate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015976">
        <property type="term" value="P:carbon utilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001765">
        <property type="entry name" value="Carbonic_anhydrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015892">
        <property type="entry name" value="Carbonic_anhydrase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036874">
        <property type="entry name" value="Carbonic_anhydrase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11002">
        <property type="entry name" value="PTHR11002"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00484">
        <property type="entry name" value="Pro_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00947">
        <property type="entry name" value="Pro_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53056">
        <property type="entry name" value="SSF53056"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00705">
        <property type="entry name" value="PROK_CO2_ANHYDRASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0456">Lyase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PJN10348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="199" mass="20435" checksum="6A9975070D75E6D4" modified="2018-04-25" version="1">MHDLSDGLARFRRDVFPAKAGLFAHLATAHHPTTLFIGCSDARVVPELITQSEPGELFVVRTAGNLVPAYASNPDGVAASIEYAVAVLHVSDIVVCGHSACGAMTALAEGHDLSAAPVVSRWLRHADAARARAAAVQAASGPGRVAALVRANVSAQLQNLATHPSVARALADGTLTLHGWVFDIATGAVEPVDATAIAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JU86</accession>
    <name>A0A2M9JU86_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">3-oxoacyl-ACP reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CG723_18650</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000005">
        <property type="protein sequence ID" value="PJN10388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN10388">
        <property type="protein sequence ID" value="PJN10388"/>
        <property type="gene ID" value="CG723_18650"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PJN10388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="276" mass="29800" checksum="13B680FEDC406D8B" modified="2018-04-25" version="1">MNARITLITGATQGLGRGIALDLAARGETLLLHGRDAGRLEAVAAEARAAAPDTTVRTYLADLSDLDQVRAMADRIRDAEPRLDVLVNNAVAGGGAEPLRRELSAQGHELRFAVNHLAPYALIRGLLPLLEASAPARVVNVASLGQERIDFDDVMLERDYEGLRAYCRSKLALIMATFELGAELEGTGVTVNALHPAHLMDTEGVRAYGLTPVTGIDEGVRPTVRLITDPELGSTTGRYFDRFTDTRAHEQAYDKEARRRLMALTDELTGYGPAAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JUA1</accession>
    <name>A0A2M9JUA1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Chitinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CG723_18465</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000005">
        <property type="protein sequence ID" value="PJN10357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN10357">
        <property type="protein sequence ID" value="PJN10357"/>
        <property type="gene ID" value="CG723_18465"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004568">
        <property type="term" value="F:chitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016998">
        <property type="term" value="P:cell wall macromolecule catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006032">
        <property type="term" value="P:chitin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003610">
        <property type="entry name" value="CBM_fam5/12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036573">
        <property type="entry name" value="CBM_sf_5/12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016283">
        <property type="entry name" value="Glyco_hydro_19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000726">
        <property type="entry name" value="Glyco_hydro_19_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023346">
        <property type="entry name" value="Lysozyme-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00182">
        <property type="entry name" value="Glyco_hydro_19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001060">
        <property type="entry name" value="Endochitinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00495">
        <property type="entry name" value="ChtBD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51055">
        <property type="entry name" value="SSF51055"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53955">
        <property type="entry name" value="SSF53955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014864069" evidence="4">
        <location>
            <begin position="30"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-3" evidence="5">
        <location>
            <begin position="33"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="2">
        <location>
            <position position="149"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="3">
        <location>
            <begin position="168"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="3">
        <location>
            <begin position="264"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR001060-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR001060-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PJN10357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="296" mass="31232" checksum="734EF9622C7A20A1" modified="2018-04-25" version="1">MIKRVTSLVATLAAVSAVVVIGPATTASAAECAAPWNSSSVYTGGGSASYNGHNWNAKWWTQNETPGTSDVWADQGACGGGGTNPGDPDPSGFVVSEAQFNQMFPNRNPFYTYSGLTAALSAYPGFANTGSDTVKRQEAAAFLANVNHETGGLVYIVEQNTANYPHYCDTSQPYGCPAGTAAYYGRGPIQLSWNFNYKAAGDALGIDLLHNPYLVEQDAAVAWKTGLWYWNTQNGPGTMTPHNAMVNGAGFGETIRSINGSLECNGGNPGQVQSRIDRYKAFVQILGTTPGDNLSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JUF6</accession>
    <name>A0A2M9JUF6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Peptidase S41</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CG723_14970</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CB01635</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S41A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000004">
        <property type="protein sequence ID" value="PJN10526.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN10526">
        <property type="protein sequence ID" value="PJN10526"/>
        <property type="gene ID" value="CG723_14970"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008236">
        <property type="term" value="F:serine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07560">
        <property type="entry name" value="Peptidase_S41_CPP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041489">
        <property type="entry name" value="PDZ_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004447">
        <property type="entry name" value="Peptidase_S41A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005151">
        <property type="entry name" value="Tail-specific_protease"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17820">
        <property type="entry name" value="PDZ_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03572">
        <property type="entry name" value="Peptidase_S41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00245">
        <property type="entry name" value="TSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="SSF50156"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0720">Serine protease</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014631257" evidence="4">
        <location>
            <begin position="35"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="5">
        <location>
            <begin position="97"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="34"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="346"/>
            <end position="370"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PJN10526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="384" mass="39759" checksum="D269CF1D32ED1B9D" modified="2018-04-25" version="1">MSGPELFSRPRRFGRGAALTLVFASVLATGVATGSWSADGHKSEELPVGSATGAGHEDVRDAAAGAMADGKSPTQAAEEAVSRSGDRWGAVYSQGEYKEFEQELDGQYTGVGLWARRTADGRIEVSKVGSGSPAAHAGVRPGDRLRTVDGRPVDGRPVTEVVSLLRGEHAGTAVRLGLERGTRAWTEILRRANLATESVSVSRLPGGTVLIKVAAFTKGSGERVRSAVRDAPHGDGVLLDLRGNSGGLVTEAVTAASAFFDGGLVATYDVRGRQRALHAERGGDTSRPVVALVDSGTMSAAELLTGALQDRGRAVVVGSKTFGKGSVQMPSRLPDGSVAELTVGHYRTPTGRGVDGRGITPDLEADEGARQRAETVLSGLGDPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JV36</accession>
    <name>A0A2M9JV36_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Phosphoesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CG723_16005</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000004">
        <property type="protein sequence ID" value="PJN10702.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN10702">
        <property type="protein sequence ID" value="PJN10702"/>
        <property type="gene ID" value="CG723_16005"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003993">
        <property type="term" value="F:acid phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP_ApaH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039331">
        <property type="entry name" value="PPA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008963">
        <property type="entry name" value="Purple_acid_Pase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015914">
        <property type="entry name" value="Purple_acid_Pase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22953">
        <property type="entry name" value="PTHR22953"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16656">
        <property type="entry name" value="Pur_ac_phosph_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49363">
        <property type="entry name" value="SSF49363"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="SSF56300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Pur_ac_phosph_N" evidence="3">
        <location>
            <begin position="78"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="domain" description="Metallophos" evidence="2">
        <location>
            <begin position="194"/>
            <end position="399"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF16656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PJN10702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="526" mass="57390" checksum="1AD4870A001F3932" modified="2018-04-25" version="1">MGVPEQLADRSLAEQHEYLRSKFSRRTMMRGGAVTLGAIAGGAFVPGAASAAVPTRTGRTPGHVPAAQKVDGALVAPFARHLAYGTDARTEMTVSWQVPVAVKNPYIRVGVHPWDLSRKIEAEVRPLYTPAGVGTGADHTQYYLHAQLTRLRPGTTYYYGVGHDGFDPAAAHLAGTLGTFRTAPSHGEPFTFTAFGDQGVSYHALANDSLILAQNPAFHLHAGDIAYADPSGSGQTSDTFDARTWDQFLAQTESVAKQVPWMVAYGNHDMEAWYAPHGYGSQQARFTLPDNGPDAENLPGVYSFVHGNTAVISLDANDVSWEIPANLGLSGGTQTSWFERRLKKFRADRGIDFIVVFFHHCAYCTATSHASEGGVRKEWVPLFEKYAVDLVINGHNHVYERTDALKGDRVTKELPIGGTAYPETDGIVYVTAGAAGRSLYAFPVDDTYEGHEKEIDPFTSFVVQPDGSKKDITVDWSRVRYTNYSFLRVDVEPAPAGHTAKLTVRGLAETGEEIDRFVIARKVRRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JV55</accession>
    <name>A0A2M9JV55_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CG723_16305</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CB01635</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000004">
        <property type="protein sequence ID" value="PJN10749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN10749">
        <property type="protein sequence ID" value="PJN10749"/>
        <property type="gene ID" value="CG723_16305"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032688">
        <property type="entry name" value="ABC2_membrane_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12679">
        <property type="entry name" value="ABC2_membrane_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="36"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="77"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="133"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="179"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="208"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="258"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PJN10749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="287" mass="30131" checksum="5C16179C1D3E6534" modified="2018-04-25" version="1">MTALVESTEVAPGYRARRTLPLRVEAVRQLKRRRTLVMGAVLALLPFVLVVAFAIGGDPGSRNGRVTLMDTATASGANFAATCLFVSAGFLLVIPVALFCGDTVASEAGWSSLRYLLAAPVPRARLLWSKLTVALALSLAAMVLLPVVALAVGTAAYGWGPLEIPTGGALPAGTAAQRLLVVIAYIFVSQLVTAGLAFWLSTKTDAPLGAVGGAVGLTIVGNVLDAVTALGDWRDFLPAHWQFAWADAIQPRPEWGGMIQGTAVSVTYAVILFALAFRGFRRKDIVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JV89</accession>
    <name>A0A2M9JV89_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_16360</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000004">
        <property type="protein sequence ID" value="PJN10758.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN10758">
        <property type="protein sequence ID" value="PJN10758"/>
        <property type="gene ID" value="CG723_16360"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="39"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN10758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="65" mass="6882" checksum="B780FB55459C7EB8" modified="2018-04-25" version="1">MTLHSAGRAGEAPSTEAPGPAALRRLRRMLALIHTSHSAATTVWAFAGAILIAPAVGWYIRMNLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JVC6</accession>
    <name>A0A2M9JVC6_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Aminopeptidase N</fullName>
            <ecNumber evidence="4">3.4.11.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Alanine aminopeptidase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">Lysyl aminopeptidase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="primary">pepN</name>
        <name evidence="16" type="ORF">CG723_16605</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">CB01635</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Release of an N-terminal amino acid, Xaa-|-Yaa- from a peptide, amide or arylamide. Xaa is preferably Ala, but may be most amino acids including Pro (slow action). When a terminal hydrophobic residue is followed by a prolyl residue, the two may be released as an intact Xaa-Pro dipeptide.</text>
            <dbReference type="EC" id="3.4.11.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the peptidase M1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.11.2" evidence="4"/>
    <dbReference type="EMBL" id="NNBL01000004">
        <property type="protein sequence ID" value="PJN10798.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN10798">
        <property type="protein sequence ID" value="PJN10798"/>
        <property type="gene ID" value="CG723_16605"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1730">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045357">
        <property type="entry name" value="Aminopeptidase_N-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042097">
        <property type="entry name" value="Aminopeptidase_N-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024571">
        <property type="entry name" value="ERAP1-like_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012778">
        <property type="entry name" value="Pept_M1_aminopeptidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001930">
        <property type="entry name" value="Peptidase_M1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014782">
        <property type="entry name" value="Peptidase_M1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027268">
        <property type="entry name" value="Peptidase_M4/M1_CTD_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11838">
        <property type="entry name" value="ERAP1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01433">
        <property type="entry name" value="Peptidase_M1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17900">
        <property type="entry name" value="Peptidase_M1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00756">
        <property type="entry name" value="ALADIPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63737">
        <property type="entry name" value="SSF63737"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02412">
        <property type="entry name" value="pepN_strep_liv"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="16" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="6" id="KW-0645">Protease</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase_M1_N" evidence="15">
        <location>
            <begin position="104"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M1" evidence="13">
        <location>
            <begin position="231"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="domain" description="ERAP1_C" evidence="14">
        <location>
            <begin position="538"/>
            <end position="847"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012564"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00015611"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00029811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00031533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF01433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF11838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF17900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="PJN10798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="856" mass="94871" checksum="2704904632FCCBBC" modified="2018-04-25" version="1">MPGTNLTREEAQQRAKLLDVESYEIDLDLSGAQEGGTYRSVTSVRFESAEAGAHTFIDLVAPAVHEVVLNGHSLDVAAVFRDSRIELKHLEAGPNELRVVADCAYTNTGEGLHRFVDPVDQQAYLYTQFEVPDARRVFASFEQPDLKATFQFTVKAPTGWTVISNSPSPEPKDDVWHFEPTPRISTYITALIVGPYHSVHSSYEGPGGQSVPLGIYCRPSLAEFLDSDAIFEVTRQGFDWFQEKFDYAYPFAKYDQLFVPEFNAGAMENAGAVTIRDQYVFRSKVTDAAYEVRAETILHELAHMWFGDLVTMEWWNDLWLNESFATYTSIACQAYSPDSRWPHSWTTFANSMKTWAYRQDQLPSTHPIMAEIRDLDDVLVNFDGITYAKGASVLKQLVAYVGMDEFFQGVQAYFKRHAYGNTRLSDLLGALEETSGRDLTAWAKAWLQTAGINILRPQIETDATGVITSFAIQQEAPALPAGAKGEPTLRPHRIAIGLYDLDDDSGKLVRVERVELDVTATELTQVPQLAGKRRPDVILLNDDDLSYAKVRLDEESLAFVTEHLGDFESSLPRALCWASAWDMTRDAELPTSAYLELVLSGIGKESDIGVVQSLHRQVKLAIDLYAAPVGRDGALASWTEATLAHLRAAEAGSDHQLAWARAFAATARTPEQLDLLEALLEGTQTIEGLAVDTELRWAFVERLAAVGRYDEPEIAAEYERDRTAAGERHAATARAARPTAEAKAEAWASVVESDKLPNAVQEAVIAGFVQTDQRDLLAPYTEKYFAAVKDVWESRSHEMAQQVAIGLYPAIQISQPTLDATESWLTTAEPNAALRRLVSESRAGVERALRAQGADA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JVF1</accession>
    <name>A0A2M9JVF1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA polymerase III subunit delta</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">holA</name>
        <name evidence="2" type="ORF">CG723_17015</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000004">
        <property type="protein sequence ID" value="PJN10866.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN10866">
        <property type="protein sequence ID" value="PJN10866"/>
        <property type="gene ID" value="CG723_17015"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009360">
        <property type="term" value="C:DNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008921">
        <property type="entry name" value="DNA_pol3_clamp-load_cplx_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010372">
        <property type="entry name" value="DNA_pol3_delta_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005790">
        <property type="entry name" value="DNA_polIII_delta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06144">
        <property type="entry name" value="DNA_pol3_delta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48019">
        <property type="entry name" value="SSF48019"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01128">
        <property type="entry name" value="holA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA_pol3_delta" evidence="1">
        <location>
            <begin position="18"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN10866.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="328" mass="34393" checksum="B8E6B00264A39578" modified="2018-04-25" version="1">MARKTATDDVLAPVTLAVGQEDLLLDRAVQQVVAAARAADADTDVRDLTSDQLQPGTLAELTSPSLFAERKVVVVRNAQDLSADTIKDVKGYFAAPAEEITLVLLHAGGAKGKGLLDAARKAGAREVACPKMTKPADRLAFVRSEFRAIGRSATPEACQALVDSIGSDLRELASAVTQLGADVEGTIDETVVARYYTGRAEASSFTVADRAVEGRAAEALEALRWSLSTGVAPVLITSALAQGVRAIGKLSSARGGRPADLARELGMPPWKIDRVRQQMRGWTPDGVAVALRALAEADAGVKGGGDDPEYALEKAVVTIARAARSRRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JVN2</accession>
    <name>A0A2M9JVN2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">5-deoxy-glucuronate isomerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">iolB</name>
        <name evidence="2" type="ORF">CG723_16275</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000004">
        <property type="protein sequence ID" value="PJN10943.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN10943">
        <property type="protein sequence ID" value="PJN10943"/>
        <property type="gene ID" value="CG723_16275"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008880">
        <property type="term" value="F:glucuronate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019310">
        <property type="term" value="P:inositol catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024203">
        <property type="entry name" value="Deoxy-glucuronate_isom_IolB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021120">
        <property type="entry name" value="KduI/IolB_isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39193">
        <property type="entry name" value="PTHR39193"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04962">
        <property type="entry name" value="KduI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036628">
        <property type="entry name" value="IolB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04378">
        <property type="entry name" value="myo_inos_iolB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN10943.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="269" mass="29062" checksum="C646EB28FBD93149" modified="2018-04-25" version="1">MNPYLPRGSAADGPYALAVGPEQAGWSRAGLRVIELGPGQTHDLDTGESEWIVLPLTGGCTVRTEGRIIELLGRESVFGGVSDFAYVPRDAHAQIASGAGGRFALAGAKCERQLPARYGPAPEVPVEHRGSGTSARQVRNFASADAFECDQLIAVEVVTPGGNWSSYPPHKHDEHRPGVETELEEIYYFEIEGPGGYGYQRVSPSRPGGTDLLAEVRTGDAVLVPDGWHGPSIAQPGHTMYYLNVMAGPGEEREWRICFHPDHLTEGYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JVN3</accession>
    <name>A0A2M9JVN3_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 3">ATP-dependent Clp protease proteolytic subunit</fullName>
            <ecNumber evidence="2">3.4.21.92</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Endopeptidase Clp</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2" type="primary">clpP</name>
        <name evidence="4" type="ORF">CG723_16760</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CB01635</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Fourteen ClpP subunits assemble into 2 heptameric rings which stack back to back to give a disk-like structure with a central cavity, resembling the structure of eukaryotic proteasomes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2 3">Belongs to the peptidase S14 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.92" evidence="2"/>
    <dbReference type="EMBL" id="NNBL01000004">
        <property type="protein sequence ID" value="PJN10955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN10955">
        <property type="protein sequence ID" value="PJN10955"/>
        <property type="gene ID" value="CG723_16760"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004176">
        <property type="term" value="F:ATP-dependent peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07017">
        <property type="entry name" value="S14_ClpP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00444">
        <property type="entry name" value="ClpP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001907">
        <property type="entry name" value="ClpP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023562">
        <property type="entry name" value="ClpP/TepA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10381">
        <property type="entry name" value="PTHR10381"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00574">
        <property type="entry name" value="CLP_protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00127">
        <property type="entry name" value="CLPPROTEASEP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 4" id="KW-0645">Protease</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0720">Serine protease</keyword>
    <feature type="active site" description="Nucleophile" evidence="2">
        <location>
            <position position="96"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PJN10955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="202" mass="21233" checksum="CB66B5F807B2D602" modified="2018-04-25" version="1">MPSAAGEPSLGGGLGDQVYSRLLNDRIIFLGQQVDDEIANKITAQMLLLAAADQAKDIYLYINSPGGSVTAGMAVYDTMQYIQNDVVTIGMGMAASMGQFLLTGGTPGKRFALPNTDILMHQGSAGIGGTASDVKIQAEYLLRTKKRMAEITARHSGQTVETIIRDGDRDRWYTAEEAKAYGLIDEIISAATGVPGGGGTGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JWB7</accession>
    <name>A0A2M9JWB7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">GDSL family lipase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CG723_09440</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN11164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN11164">
        <property type="protein sequence ID" value="PJN11164"/>
        <property type="gene ID" value="CG723_09440"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013830">
        <property type="entry name" value="SGNH_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13472">
        <property type="entry name" value="Lipase_GDSL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014799573" evidence="2">
        <location>
            <begin position="42"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="domain" description="SGNH_hydro" evidence="3">
        <location>
            <begin position="218"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="41"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="50"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PJN11164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="424" mass="44663" checksum="A019E0A16EE3034D" modified="2018-04-25" version="1">MTLDQPHRAVRSRARRRPLWPLFGTLLALALAVAPVGTAGAATPSAHAPGTRVSAWSPSMTTGGPSFENQTIRMVVHSSVAGSRARITLSNRYSPGPLEVAAANVAVQAHGGEARPGTARRITFGGSDRVTLPAGGEAVSDVVPISVRAGQNLLVSLYVPGATGMSTWHSDAFDTTYTASGDHAGDESAADFVTTTTSWYYLAGLDVLSPTAKGTVVAFGDSITDGYHSSTGTYTRWPDVLGRRLEAEPGPQRLSVVDAGIGGNRVLTDVPNLWQGVSALKRFRHDALGQPGVKDVILFEGINDIGNNAGPDGRPLTAQDLIDGWRTLIDEAHAAGVRVIGATLMPVKGNGYYTPAAEELRRSVNDWMRTGGAFDGVIDFDRVMRDPADPSALNPAYDSGDHIHPDDAGMKAMADAVDLGLLRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-05-25" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JWJ8</accession>
    <name>A0A2M9JWJ8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Nitroreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_10090</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>a quinol + H(+) + oxidized coenzyme F420-(gamma-L-Glu)(n) = a quinone + reduced coenzyme F420-(gamma-L-Glu)(n)</text>
            <dbReference type="Rhea" id="RHEA:39663"/>
            <dbReference type="Rhea" id="RHEA-COMP:12939"/>
            <dbReference type="Rhea" id="RHEA-COMP:14378"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
            <dbReference type="ChEBI" id="CHEBI:133980"/>
            <dbReference type="ChEBI" id="CHEBI:139511"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the F420H(2)-dependent quinone reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN11275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN11275">
        <property type="protein sequence ID" value="PJN11275"/>
        <property type="gene ID" value="CG723_10090"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004378">
        <property type="entry name" value="F420H2_quin_Rdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04075">
        <property type="entry name" value="F420H2_quin_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00026">
        <property type="entry name" value="hi_GC_TIGR00026"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00029371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN11275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="152" mass="17204" checksum="6977D00A31352075" modified="2018-04-25" version="1">MAQDETGTDVVISPTGWVAEQARLYEESGGTEGTTIPGPMSAPCLLLDYQGRHSGKWRRTVLIYDRDGDDYLIVASKGGADQHPEWYLNLEANPDVRLRVETERFAARAETLSQEEKARVWPHLVEIFAPYADYQKKTERDIPVVRLTRIKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JWR0</accession>
    <name>A0A2M9JWR0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Succinate dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CG723_10390</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CB01635</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[3Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:21137"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN11330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN11330">
        <property type="protein sequence ID" value="PJN11330"/>
        <property type="gene ID" value="CG723_10390"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051538">
        <property type="term" value="F:3 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1060.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036010">
        <property type="entry name" value="2Fe-2S_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001041">
        <property type="entry name" value="2Fe-2S_ferredoxin-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006058">
        <property type="entry name" value="2Fe2S_fd_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009051">
        <property type="entry name" value="Helical_ferredxn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025192">
        <property type="entry name" value="Succ_DH/fum_Rdtase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13085">
        <property type="entry name" value="Fer2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13183">
        <property type="entry name" value="Fer4_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54292">
        <property type="entry name" value="SSF54292"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00197">
        <property type="entry name" value="2FE2S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51085">
        <property type="entry name" value="2FE2S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0003">3Fe-4S</keyword>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="2Fe-2S ferredoxin-type" evidence="7">
        <location>
            <begin position="1"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="8">
        <location>
            <begin position="149"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PJN11330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="249" mass="26715" checksum="86EDAF44B0FD53A3" modified="2018-04-25" version="1">MKLTLRVWRQKNADAEGAMSTYDVDGISQDMSFLEMLDTLNEELIVKGDDPVAFDHDCREGICGACSLVINGDAHGPERTTACQLHMRSFKDGDTIDIEPWRASAFPVVKDLVVDRTAFDRIIQAGGYISAPTGAAPEAHATPVPKPDADFAFEHAECIGCGACVAACPNGSAMLFTSAKVNHLNVLPQGAPERETRVLDMVGQMDAEGFGGCTLTGECATACPKGIPLVSITGMNREWLRATRKAGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JWS1</accession>
    <name>A0A2M9JWS1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="16">ABC transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">CG723_10405</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN11333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN11333">
        <property type="protein sequence ID" value="PJN11333"/>
        <property type="gene ID" value="CG723_10405"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004518">
        <property type="term" value="F:nuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041552">
        <property type="entry name" value="UvrA_DNA-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17755">
        <property type="entry name" value="UvrA_DNA-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0227">DNA damage</keyword>
    <keyword evidence="6" id="KW-0228">DNA excision</keyword>
    <keyword evidence="12" id="KW-0234">DNA repair</keyword>
    <keyword evidence="11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="10" id="KW-0267">Excision nuclease</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="ABC transporter" evidence="15">
        <location>
            <begin position="464"/>
            <end position="770"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="87"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="89"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="501"/>
            <end position="508"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="PJN11333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="789" mass="84076" checksum="A1B1403003030A30" modified="2018-04-25" version="1">MHEPDHDPFVRVRGAREHNLRGVDVDIPRDVLAVFTGVSGSGKSSLAFGTIYAEAQRRYFESVAPYARRLIHQVGAPKVGEITGLPPAVSLQQRRSSPTSRSSVGTVTTLSNSLRMLFSRAGDYPPGAQRLDSDAFSPNTAAGACPECHGLGVVHRTTEALLVPDPSLSLREGAIAAWPGAWQGKNLRDVLDALGYAVDRPWRELPQEERDWILFTDDQPVVTVHPVRDAGRIQRPYQGTYMSANRYVLKTFADSKSQTLRTKAERFLDSAPCPVCGGARLRAESLAVTFGGRTIADLAHLPLADLAKILDAPGDASETARVLTGDLLARIATVAELGLGYLSLDRATPTLSAGELQRLRLATQLRSGLFGVVYVLDEPSAGLHPADTESLLTVLDRLKAAGNSVFVVEHHMDVVRKADWLVDVGPLAGEHGGHVLHSGPVADLASVADSATARFLFGREHVPVRTVREPRSWLKVGPVTRHNLRDVSVDVPLSTFTAVTGVSGSGKSTLIGSITEELEGVGRLVVVDQKPIGRTPRSNLATYTGLFDVVRKVFAATDEAKARKYGVGRFSFNVAGGRCETCQGEGFVSVELLFLPSTYAPCPDCGGARYNAETLEVAYRGRTIAEVLDLTVESAAEFFADTPAVARSLGTLLDVGLGYLRLGQPATELSGGEAQRIKLASELQRGRRGSTLYLLDEPTTGLHPADVEVLMRQLHGLVDAGHTVVVVEHDMAVVAGADWVIDLGPGGGDAGGRIVAAGPPTEVARASGSATAPYLARAFPPGALPEARS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-09-29" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JWZ9</accession>
    <name>A0A2M9JWZ9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_10050</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN11267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN11267">
        <property type="protein sequence ID" value="PJN11267"/>
        <property type="gene ID" value="CG723_10050"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002397">
        <property type="entry name" value="Cyt_P450_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00359">
        <property type="entry name" value="BP450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="SSF48264"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="52"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN11267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="407" mass="44776" checksum="66CF06523316E3EF" modified="2018-04-25" version="1">MTLDTMLAQITDYANRADPYPLYAALRESPVTCQNDGSYLVSTYYEVRSLANDPRLSNDPRKRTPGADVPAVTKEDPNLPPSFLLLDPPEHDRLRNAAMRPFGPPHSPRFLHDMRGELAGVVADLVDALEGKDEIDVVDDFAYPLPVTAICKVLGVPREDEARFHGWADTVASGIDPSGGESGLERARKARGELGAYLSDLIETKRHDQGSGILGPLARETGPGGSMSTAELVATSILLLIAGHETTVNLISNATLTLLRHPDVLERFRTEPDLVVPLIEEVLRYEPPVQFIPWATALADIDIAGTTIPKGSAVQLMLASANRDPKRFEDPDRFDPDREDNEHLGFYTGIHYCFGAPLARMEAQLALPELVRRIRDPRLLADPPPYRVNPVLRGPRHLRLAIDGLTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JX00</accession>
    <name>A0A2M9JX00_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Pentachlorophenol monooxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_10940</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN11423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN11423">
        <property type="protein sequence ID" value="PJN11423"/>
        <property type="gene ID" value="CG723_10940"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD_binding_3" evidence="1">
        <location>
            <begin position="11"/>
            <end position="349"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN11423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="473" mass="50913" checksum="4C7033C4632B35CB" modified="2018-04-25" version="1">MDTRADTITHTEVLVVGAGPTGLALAADLARRGVDALVVERADALFPGSRGKGIQPRTREVFHDLGVLDAIHAAGGPYPVGMIWQDGTRVGEHRMFDPAEQSDDSPYTEPWMVPQWRTQQILFERLMQLGGRVEFGRELVAVEQDADAVTAHFAAGEQVSARYAVAADGGRSTVRRALGIGMTGETVDPHPMLVADVRITGLDRDNWHVFPPREGSDGFLAICPLAGIEDFQVTAQFPEGTVPDLSLDGIRKVVAARSHLAPEDVTEVRWASDFRPRAALADRFRAGRVLLAGDAAHVHSPAGGQGLNTSVQDAYNLGWKLGGVLRDGAPESLVETYEEERRPVAAHMLGISTGVHRGEIRRGEATRQLGLGYRESSLAVDTRTIAGPVRAGDRAPDGTVDGVRLFDTFRGPHWTLLTVGTDTELPELGVPTVRIPACEVYGAGVYLVRPDGYVGWAGDTADGLAEYARRMGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JX64</accession>
    <name>A0A2M9JX64_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Glycosyl transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CG723_11285</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN11479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN11479">
        <property type="protein sequence ID" value="PJN11479"/>
        <property type="gene ID" value="CG723_11285"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044249">
        <property type="term" value="P:cellular biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901576">
        <property type="term" value="P:organic substance biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028098">
        <property type="entry name" value="Glyco_trans_4-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13439">
        <property type="entry name" value="Glyco_transf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_4-like_N" evidence="4">
        <location>
            <begin position="17"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="domain" description="Glycos_transf_1" evidence="3">
        <location>
            <begin position="216"/>
            <end position="369"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PJN11479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="413" mass="44183" checksum="7EE6EA6300899B56" modified="2018-04-25" version="1">MHVLVVHNRYASAQPSGENKVVDQEVELLRAAGHRVEVFERRSDTIAARSLPGKVAVPLLVPWNPAVRAELAARLRTERPDVVHVHNVFPLLSPAVLAACADAGVPAVATLHNYTQVCPPGTLQRDGRPCTECVGSAPLPAVRHGCYRNSRLATVPLAVSLSVNRRRWWSGVERFFCISAAQRDVLVRAGMPPERLAVKHNFVPEPGTCRTGTGEHLLYLGRLAEAKGVRLLMAAWDRIAADGGVGVPLVIAGTGPLEREVTAWAAGRDDVRYVGLYDTVQCRKAIARSVAVVAPSTWLEAFGLVVVEAMAAGVPTVAAGHGAFVELVEDGVTGLLHRPGEVASLADRMRRITAGTARNQEMGQAARRRYEQGFSPAVGLERLVEEYRTAIAGRSALARGGGTRASRGDGGSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JXC0</accession>
    <name>A0A2M9JXC0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MarR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_11575</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN11534.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN11534">
        <property type="protein sequence ID" value="PJN11534"/>
        <property type="gene ID" value="CG723_11575"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000835">
        <property type="entry name" value="HTH_MarR-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023187">
        <property type="entry name" value="Tscrpt_reg_MarR-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01047">
        <property type="entry name" value="MarR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00347">
        <property type="entry name" value="HTH_MARR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01117">
        <property type="entry name" value="HTH_MARR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50995">
        <property type="entry name" value="HTH_MARR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH marR-type" evidence="1">
        <location>
            <begin position="11"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN11534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="148" mass="16054" checksum="4DEF4FB46433D2DA" modified="2018-04-25" version="1">MQRETADEPLAEQVAADLSAVVGRLLRRLRTASPDSLLTPTQRTVLARLDGEGPATTAALARAEYVRPQSMRLTLAALEEQDFVARTPDPDDGRQSVVAITESGRHTLASVRAAKHSWLVQAVAGELDEAELRTLAEATALMERLVEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-09-29" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JXG3</accession>
    <name>A0A2M9JXG3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Cytosine or purine or uracil or thiamine or allantoin permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CG723_11835</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CB01635</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the purine-cytosine permease (2.A.39) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN11574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN11574">
        <property type="protein sequence ID" value="PJN11574"/>
        <property type="gene ID" value="CG723_11835"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001248">
        <property type="entry name" value="Pur-cyt_permease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026030">
        <property type="entry name" value="Pur-cyt_permease_Fcy2/21/22"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31806">
        <property type="entry name" value="PTHR31806"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02133">
        <property type="entry name" value="Transp_cyt_pur"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002744">
        <property type="entry name" value="Pur-cyt_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="54"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="80"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="125"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="162"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="193"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="225"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="264"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="304"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="344"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="369"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="411"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="446"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR002744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PJN11574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="478" mass="49734" checksum="E7FD3E4180F5E2FC" modified="2018-04-25" version="1">MTQQHTEEAGPADAGPAQAGPAVATTGDEVFQVETHGIDPIPDEERHGGAKDLFWLWFGSNLTFTYVINGALAVSFGLSFWQATAAVVVGGLAFFAISAAGLSGIRTGTATLVISRAPFGIRGNWPAGLLNWIVSIGYTIVNTVVGALALEAFCADLGWHGSTARAFALAVTMVLTFAVALWGHATVQFAERWMAYILAVGFAALLVFLIPGADTGASTGGVPGASGWSLAFVVMLAGPFSYVPMPADYTRYLPRTTSLRSITWSGALGGLISSVALGVAGVAAATQADMSDAVAGAEGLLPGWFQPLFLALVLGGSVTNSIITLYSSSLNLQVLGIPWSRAKAILISAGVTVVGSLYALFLTDFTDSLLSFLSLLIIVFAPWGGVFLADMVMRRCRYDAPSLHTGREGAYWYRCGYHPAGVVALLAGIVFASLTCDSELWTGPLVAPLGGADLTLLGSVVSALVYWALARRTVAPAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JXK2</accession>
    <name>A0A2M9JXK2_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 11 12">Xylose isomerase</fullName>
            <ecNumber evidence="4 11 12">5.3.1.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11 15" type="primary">xylA</name>
        <name evidence="15" type="ORF">CG723_11380</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">CB01635</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10 11 12">
            <text>alpha-D-xylose = alpha-D-xylulofuranose</text>
            <dbReference type="Rhea" id="RHEA:22816"/>
            <dbReference type="ChEBI" id="CHEBI:28518"/>
            <dbReference type="ChEBI" id="CHEBI:188998"/>
            <dbReference type="EC" id="5.3.1.5"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="11">Binds 2 magnesium ions per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 11 13">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11 13">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11 12">Belongs to the xylose isomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.5" evidence="4 11 12"/>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN11497.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN11497">
        <property type="protein sequence ID" value="PJN11497"/>
        <property type="gene ID" value="CG723_11380"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009045">
        <property type="term" value="F:xylose isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042732">
        <property type="term" value="P:D-xylose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00455">
        <property type="entry name" value="Xylose_isom_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036237">
        <property type="entry name" value="Xyl_isomerase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013022">
        <property type="entry name" value="Xyl_isomerase-like_TIM-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013453">
        <property type="entry name" value="XylA_actinobac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001998">
        <property type="entry name" value="Xylose_isomerase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01261">
        <property type="entry name" value="AP_endonuc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00688">
        <property type="entry name" value="XYLOSISMRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51658">
        <property type="entry name" value="SSF51658"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02631">
        <property type="entry name" value="xylA_Arthro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51415">
        <property type="entry name" value="XYLOSE_ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 11 12" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="6 11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8 11 12" id="KW-0413">Isomerase</keyword>
    <keyword evidence="11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7 11 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11 12" id="KW-0859">Xylose metabolism</keyword>
    <feature type="domain" description="AP_endonuc_2" evidence="14">
        <location>
            <begin position="41"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="active site" evidence="11">
        <location>
            <position position="54"/>
        </location>
    </feature>
    <feature type="active site" evidence="11">
        <location>
            <position position="57"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="181"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="217"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="220"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="245"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="287"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00018232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00033659"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000610"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF01261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="PJN11497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="388" mass="42925" checksum="9725867126695C0A" modified="2018-04-25" version="1">MTYRPTPDDKFSFGLWTVGWQGRDPFGDATRAALDPAESVRRLADLGAYGVTFHDDDLIPFGASDTERESHVKRFRQALDSTGLIVPMATTNLFTHPVFKDGAFTANDRDVRRYALRKTIRNIDLAVELGAKTYVAWGGREGAESGAAKDVRAALDRMKEAFDLLGEYVVQQGYDLKFAIEPKPNEPRGDILLPTVGHALAFIERLERPEMYGVNPEVGHEQMAGLNFPHGIAQALWAGKLFHIDLNGQTGIKYDQDLRFGAGDLRSAFWLVDLLETAGYEGPRHFDFKPPRTEDYDGVWASAEGCMRNYLILRERAAAFRADPEVQEALRASRLDELVQPTAADGLSGLLADASAFEGFDVEAAAARGMAFERLDQLAMDHLLAARG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JXR3</accession>
    <name>A0A2M9JXR3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CG723_12415</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CB01635</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN11669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN11669">
        <property type="protein sequence ID" value="PJN11669"/>
        <property type="gene ID" value="CG723_12415"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="44"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="104"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="137"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="183"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="231"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="293"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="100"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PJN11669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="323" mass="34689" checksum="E0EF61E9D8E96BAC" modified="2018-04-25" version="1">MTSPLPTVKTAAKSPANADVTSPAKPSGERPASRVRRHLPTSPWLFAAPGLLVVAVFILYPFVSTVVNSFTDRRTLIPGEFVGLANFRELLHDDMFWTGLRNSVLYMVGVVPALVLLPLLLALLVQKNIPGITFFRSAFYTPVVASIVVVGLIWVWMLDERGLVNSLLEAVGIGKVGFLSDQWLLLLSAMAVTVWKGLGYYMIIYLAALANVPRELHEAASVDGAGAVRRFFTVTVPAVRSTMVLVAALSSVAAFKVFSEVYLMAGPNGGPAGEDTTLVMLVQRTGTGLTGRVGYASAISVVVFVVTVALMLLVLRADRKEDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JXW6</accession>
    <name>A0A2M9JXW6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_12765</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN11726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN11726">
        <property type="protein sequence ID" value="PJN11726"/>
        <property type="gene ID" value="CG723_12765"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001845">
        <property type="entry name" value="HTH_ArsR_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="SMART" id="SM00418">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH arsR-type" evidence="1">
        <location>
            <begin position="9"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN11726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="187" mass="20953" checksum="E1FBFF979A462C83" modified="2018-04-25" version="1">MAPPITDSRVLAAMAHPVRRRLLDLLKLDGPSTASALSQATGEAVGNVSHHLKALAAAGLIEEAPELARDRRERWWRRTTPKLLWSSVDFADDAAGEAVAQAAESLSLERQINQVRRWADQPQSEQQRWPLGPFVAEVWLRMTDAELAQFKDEIVEVMDRWAGRELPDDGQERETVFTFTRAVPGHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JY21</accession>
    <name>A0A2M9JY21_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ABC transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_12975</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN11761.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN11761">
        <property type="protein sequence ID" value="PJN11761"/>
        <property type="gene ID" value="CG723_12975"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022703">
        <property type="entry name" value="DUF3533"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12051">
        <property type="entry name" value="DUF3533"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="25"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="218"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="273"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="301"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="391"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="domain" description="DUF3533" evidence="2">
        <location>
            <begin position="31"/>
            <end position="399"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN11761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="429" mass="45401" checksum="0912D53BF7764F8B" modified="2018-04-25" version="1">MDDDSAPRHAAAKARASALVRRPKLWLVPTILTGMLALLLSLLYMGGIVNPNRDLQNLPIALVNSDRGKPLPGQSRNLGTQVAQAALANTSGGKVDWHPLTRGMAQDELESGKVYGALVIPPDFTDSIGALGTSRATQRPTLTVLTNPGMGSLGSSLAGRISTTAAEQASRTIGKQLTEANADRQVTPTARLLLADPISVTTQVGHPIGDHSGLGLSAFYYTLLLVLTGFLGANLTSMGVDTALGYADSEIGPWHARRPTVPISRTQTLLLKMVMSAGITLLTTTLIMLATVGILGMDASYLPLLWVFSYCATLAVSLGVQAINAAFGGIGQLVSMFVFIVLGLPSSGATIPLEAVPGFYRFLGIFEPMRQLSGGVRSILFFEARADAGLLRAWIMIAVGSVISAVFGFAMTRYYDRKGLHRLTPQPSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JY72</accession>
    <name>A0A2M9JY72_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Nickel ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CG723_13260</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CB01635</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN11808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN11808">
        <property type="protein sequence ID" value="PJN11808"/>
        <property type="gene ID" value="CG723_13260"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045621">
        <property type="entry name" value="BPD_transp_1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19300">
        <property type="entry name" value="BPD_transp_1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014637728" evidence="6">
        <location>
            <begin position="38"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="112"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="146"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="197"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="258"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="300"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="7">
        <location>
            <begin position="110"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PJN11808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="333" mass="35260" checksum="1C86B300FB804EA4" modified="2018-04-25" version="1">MTSFLMRRFVAMIVLLFVISFVTFSLFQLGPADPAAAACGQECTPQRIAEARVALGMDKPFLTQYFTYMSGLVGSHTVGAPGAETLCNWPCLGKSFQTNEDVTTIIGRALPYTLSVASGAIVLWTIAGVGLGLLAALRKGRFADKLIVGGASVGVSLPIPVTGLLLLLLFVSTLDLLPFTTNEIATPFDAAGPGGWLLNYLLPWVALAVLFSAQYIRVTRSNMLETFGEDFMRTARAKGLSRRNIVFKHGARAGITPVVTMLGLDIGGLLGGAVLTEQIFSVPGVGFTAVHAAQAGDLPVTMAITMMAAFFIIVANVVVDIAYAVIDPRVRVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JY76</accession>
    <name>A0A2M9JY76_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Chloramphenicol phosphotransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CG723_13345</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN11822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN11822">
        <property type="protein sequence ID" value="PJN11822"/>
        <property type="gene ID" value="CG723_13345"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016774">
        <property type="term" value="F:phosphotransferase activity, carboxyl group as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023865">
        <property type="entry name" value="Aliphatic_acid_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012853">
        <property type="entry name" value="CPT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF007531">
        <property type="entry name" value="CPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01075">
        <property type="entry name" value="ACETATE_KINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 7" id="KW-0808">Transferase</keyword>
    <feature type="active site" evidence="5">
        <location>
            <position position="37"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="10"/>
            <end position="17"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR007531-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR007531-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PJN11822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="177" mass="18428" checksum="B900AC71C0F3FA28" modified="2018-04-25" version="1">MTTQVIVLNGGSSSGKSGIVRCLQAVLPDPWLAFGIDRLIEAMPASMKASGEGIEITSAGAVSVGAVFQELEAAWMEGVAATAGAGARIVIDDVFLGGTESQQRWQKALGGLDVLWVGVRCDSEVAAGREIVRGDRAQGMAAGQAETVHRGVVYDLEVDTTHTESLECARTIAAQVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-09-29" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JYE0</accession>
    <name>A0A2M9JYE0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Nitrate reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CG723_13730</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CB01635</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the purine-cytosine permease (2.A.39) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN11885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN11885">
        <property type="protein sequence ID" value="PJN11885"/>
        <property type="gene ID" value="CG723_13730"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001248">
        <property type="entry name" value="Pur-cyt_permease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026030">
        <property type="entry name" value="Pur-cyt_permease_Fcy2/21/22"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31806">
        <property type="entry name" value="PTHR31806"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02133">
        <property type="entry name" value="Transp_cyt_pur"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002744">
        <property type="entry name" value="Pur-cyt_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="47"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="77"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="119"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="159"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="185"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="225"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="264"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="304"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="339"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="373"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="421"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="447"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="15"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR002744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PJN11885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="479" mass="50700" checksum="DE191B39CB482E64" modified="2018-04-25" version="1">MALRATGGTSEGPERGEPVTDRTGHVETHGVDHIPDSDRHGRPRSLFTVWAASNMSYLYIVLGGAMVLLGLDIWQSFAVIVAGNLLWAGVGYLAISGPTSGTPSWVVTRAMFGVRGNRVLNVTLGWTVAVAYEAISLALGSLAGFALVEHLGIHANTPVKVAIVLVTAVVTFSISVYGHATIMRCSIWFTWALAACVLVLAYYVLRHTDWGYRTPAATAVHGRELWVILASGFTIMAGGPLSWSSSADYARYLPADTSRKAVCWWTAVGGFVPAVLLSGLGVLAGTAVDMTDAQTSLKAVVPDWFYPVFLLVVIFGSITNNVLTAYSGGLALQSGGIPWSRAFTVIFDASIALGLTFYSLFVSDFLDTMNSGLELSVAFLGPGFAIYAVDIFLRRNRYDGVALQDQTSNSRFWYRHGVNPAGAAAWAIGVGAALLCANTAIYTGPVAAALGGADLSAVVGMSLGALVYAGSMLRQRRSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-09-29" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JYR7</accession>
    <name>A0A2M9JYR7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Acyl-coenzyme A--6-aminopenicillanic-acid-acyltransferase form</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CG723_14500</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN12015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN12015">
        <property type="protein sequence ID" value="PJN12015"/>
        <property type="gene ID" value="CG723_14500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005079">
        <property type="entry name" value="Peptidase_C45"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03417">
        <property type="entry name" value="AAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PJN12015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="394" mass="42638" checksum="D781DCBFC419E240" modified="2018-04-25" version="1">MTPRPTETAPTRVLPVIEISGSPLDRGRQYGEAVRPQLHAALGYYEEAFGQSAGLTWDRVTARAARWLDPVRDYAPHLVDEMRGIADGAGVDLLDVLALNARGEVIYDKSFAQMEADGRTPEEEPAEGCTSFAAYGEASGDGHVYAGQNWDWRAGVADTVVMIRIVQPPKPTLIMQVEAGQIGRQGANSAGIAFNANGLGGRFDDAIGLPQTVVRRSVLDQSNITDALDVLCRTRAHIASNALLTCREGFAIDLETTPAGHGWMYPTDGLLVHGNHYQAGVPAQLAAAGYRPMSSDSLVRVPRAEQGLRALRGSTGPDESRKIIRHAMSDHLGLPESLCTHPDPRQPAVKHWTTLVSSLADLTTGDYHVTAGTPCDREYQHLPWNLYDGPYGQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JZ08</accession>
    <name>A0A2M9JZ08_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_08755</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN12100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN12100">
        <property type="protein sequence ID" value="PJN12100"/>
        <property type="gene ID" value="CG723_08755"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002509">
        <property type="entry name" value="NODB_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01522">
        <property type="entry name" value="Polysacc_deac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="SSF88713"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51677">
        <property type="entry name" value="NODB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014864072" evidence="1">
        <location>
            <begin position="38"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="domain" description="NodB homology" evidence="2">
        <location>
            <begin position="71"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN12100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="257" mass="27338" checksum="FDFFE852625FCFC2" modified="2018-04-25" version="1">MARQSNGRGWNSKVVGAALGVTLLATSASVWTAQAGAADGSSPEATAPAAPGGDVRPTAVTIAHASDAGTRGINITIDDGPDPEWTPQVLDVLREFEVKATFCMVGPQAQAHPDLVKKVVAAGHRLCDHSASHDTAMDKKSEAYQSQQILDAERMITKASGGVRPMYYRAPGGAFTPYSRKLAASRGMRPLGWNVDSKDFERPGTDTIVATVERELPNGPTLLFHDAGGDRAQTVEALRRTLPQLKEQGYSFGFPVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JZ56</accession>
    <name>A0A2M9JZ56_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Molybdopterin synthase sulfur carrier subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CG723_10900</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN12146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN12146">
        <property type="protein sequence ID" value="PJN12146"/>
        <property type="gene ID" value="CG723_10900"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016155">
        <property type="entry name" value="Mopterin_synth/thiamin_S_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003749">
        <property type="entry name" value="ThiS/MoaD-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02597">
        <property type="entry name" value="ThiS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54285">
        <property type="entry name" value="SSF54285"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PJN12146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="87" mass="9070" checksum="0A8B22CBCDEA9002" modified="2018-04-25" version="1">MTPAGTIRYWAAAKAAAGTAQEPYRAATLAEALAQVRSRHDGRPRLARVLGYCSFLVDGRPVGGRDHASVHLAEGGTVEVLPPFAGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JZB6</accession>
    <name>A0A2M9JZB6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CG723_13940</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN12222.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN12222">
        <property type="protein sequence ID" value="PJN12222"/>
        <property type="gene ID" value="CG723_13940"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015424">
        <property type="term" value="F:ABC-type amino acid transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030679">
        <property type="entry name" value="ABC_ATPase_HisP-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039085">
        <property type="entry name" value="ABC_ATPase_HisP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="18"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="50"/>
            <end position="57"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PJN12222.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="265" mass="28843" checksum="0D3C3E04BAC04C72" modified="2018-04-25" version="1">MTNATTTDTSAPTPTRAIEIRALHKSFGDLEVLRGIDFTVDTGEVVCVIGPSGSGKSTLLRCTNLLEQPTQGRVLIAGTDITDPDVDIDRLRRRIGMVFQQFNLFAHLSVLDNLTITQRRVLGRDKTEAVQVARQNLARVGLADKEGSYPSQLSGGQQQRVAIARALSMGPELMLFDEPTSALDPELVGDVLAVMRGLADDGMTMMVVTHEMGFAREVADRVVFMDDGVIVEQGSPDEVLGNPSHPRTREFLARVLRPADTLTES</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JZN9</accession>
    <name>A0A2M9JZN9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Sugar ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CG723_04385</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CB01635</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000002">
        <property type="protein sequence ID" value="PJN12300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN12300">
        <property type="protein sequence ID" value="PJN12300"/>
        <property type="gene ID" value="CG723_04385"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="35"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="95"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="128"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="172"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="226"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="280"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="91"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PJN12300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="313" mass="34675" checksum="BCD7FA79F89BED18" modified="2018-04-25" version="1">MTTSAETVIAPPRAQAAAAGAATVGRKQGFQHGGWFVAPFLALFAFFVIWPLLRGVYLSFTDANISGDSAGFIGFDNYREALHDPLMWDSLGHSAFFTLLVVPCITVLAFLLAMLAHHIERGTWLWRLCFFLPFLLPSTVAGNLWQWLFNPGTGMVNHVFGIDTPWLTDKSYAMLAVVITTLWWTVGFSFLLYLAALQGIPGHLYEAAKLDGANAWHRVVHITLPMLRNITGLVIALQILASLQVFDQAVVMQDFGPGPEESTRTFVQFTLEQGFTSYRVGYASAISVIFFVIIAAVALARMWLLRNREEGAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JZP6</accession>
    <name>A0A2M9JZP6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">MerR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_04540</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000002">
        <property type="protein sequence ID" value="PJN12328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN12328">
        <property type="protein sequence ID" value="PJN12328"/>
        <property type="gene ID" value="CG723_04540"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000551">
        <property type="entry name" value="MerR-type_HTH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13411">
        <property type="entry name" value="MerR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00040">
        <property type="entry name" value="HTHMERR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00422">
        <property type="entry name" value="HTH_MERR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="SSF46955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50937">
        <property type="entry name" value="HTH_MERR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH merR-type" evidence="2">
        <location>
            <begin position="31"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN12328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="153" mass="17456" checksum="11589ACDF4DFD654" modified="2018-04-25" version="1">MTVMETTPAPSKADVCASAPTAHPRPEGQDHYTISEVVAFTGLTAHTLRWYERIGLMPHIDRSHTGQRRYSNRDLDWLTFVGKLRLTGMPVAHMVRYAELVRVGEDTFEERRELLESTRRDVLSRIAELQDTLSVLDLKIDFYAGARRASERA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-09-29" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JZT1</accession>
    <name>A0A2M9JZT1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Proline/betaine transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CG723_04815</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CB01635</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000002">
        <property type="protein sequence ID" value="PJN12376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN12376">
        <property type="protein sequence ID" value="PJN12376"/>
        <property type="gene ID" value="CG723_04815"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="72"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="105"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="129"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="170"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="205"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="263"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="301"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="330"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="355"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="394"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="425"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="7">
        <location>
            <begin position="33"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PJN12376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="471" mass="49641" checksum="DA194196C41539D9" modified="2018-04-25" version="1">MSSALTVAPRTNAPAKGASPEVTVTDPVLVKRAVKAAALGNAMEWFDFGVYSYIAVTLGKVFFPSGNPTAQLLATFGAFAAAFLVRPIGGMVFGPLGDRVGRQKILAVTMIMMAAGTFAIGLIPSYATIGVWAPILLLLARLVQGFSTGGEYGGASTFIAEYAPDKKRGFFGSWLEFGTLAGYIGGAGLVTLMTALLSSDDLLSWGWRIPFLIAGPMGIIGLYLRMRLEETPAFAAELKNAHESEKARPKVKVRDMIAGQWKALLLCVGLVLVFNVTDYMLLSYMPSYLTSELHYDETHGLLVVLGVMALMMIVQPFAGALSDRVGRRPVIAAGCVGFLALSVPALLLIREGSLWAIALGMGALGLLLVCFTSAMPSALPALFPTRVRYGSLSIGFNISVSLFGGTTPLVVTALIGATGNMMMPAYYMMAAAVIGGVAVWFMTESARRPLPGSLPAVEPCDLPQTATATAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K014</accession>
    <name>A0A2M9K014_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">TetR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_05370</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000002">
        <property type="protein sequence ID" value="PJN12469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN12469">
        <property type="protein sequence ID" value="PJN12469"/>
        <property type="gene ID" value="CG723_05370"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011075">
        <property type="entry name" value="TetR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16859">
        <property type="entry name" value="TetR_C_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="18"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="42"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN12469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="202" mass="22707" checksum="BF4717D4631E58CE" modified="2018-04-25" version="1">MVVDVDAGRAVRGRPRSEAVERAIVEGVLKLIEDGVPLTDLSIERIARTAGVGKATIYRRWSGKEELFVEVLRIMEEPDPELPGTSVRDDLISLLEHLRRRGVSLRSSALLHNVFAQMKSLPKLWDAYHDTVIEPRRRVMFDVLRRGVENGELRADVDIELINDFIVGPMLLRTIIRPDAPLADDLSEQIVDCALAGLRPQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K033</accession>
    <name>A0A2M9K033_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">PAP2_3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CG723_05495</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CB01635</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000002">
        <property type="protein sequence ID" value="PJN12489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN12489">
        <property type="protein sequence ID" value="PJN12489"/>
        <property type="gene ID" value="CG723_05495"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026841">
        <property type="entry name" value="Aur1/Ipt1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14378">
        <property type="entry name" value="PAP2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="42"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="108"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="138"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="192"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="221"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="245"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="domain" description="PAP2_3" evidence="7">
        <location>
            <begin position="76"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF14378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PJN12489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="287" mass="31945" checksum="84C72D0718FAF09B" modified="2018-04-25" version="1">MGESTVTTLEGRQGPTTSPMADDRRDGRGLLGRIRAPRRPRLWFEILLIAVSYWTYSLIRNAVPEQRSQALSNADWIWRMEHHLSIAVEENVNHAVNSVTWLIVGMNYYYATLHFIVTLGVLVWLFRYHPGRYAAARLALFATTAVALVGYYLYPLAPPRLMNGGHFVDTVAVHHTWGSMASGDLKHMSNQYAAMPSMHIGWSLWCGLTIFALASAPWVRILGLLYPALTLVVIVSTANHFWLDAVGGMVCLAFGFTMARIWYGALPHTMPRLVHAPATSGVTPPGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-05-25" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K066</accession>
    <name>A0A2M9K066_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">LacI family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CG723_05500</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000002">
        <property type="protein sequence ID" value="PJN12490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN12490">
        <property type="protein sequence ID" value="PJN12490"/>
        <property type="gene ID" value="CG723_05500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01392">
        <property type="entry name" value="HTH_LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000843">
        <property type="entry name" value="HTH_LacI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046335">
        <property type="entry name" value="LacI/GalR-like_sensor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00356">
        <property type="entry name" value="LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13377">
        <property type="entry name" value="Peripla_BP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00036">
        <property type="entry name" value="HTHLACI"/>
    </dbReference>
    <dbReference type="SMART" id="SM00354">
        <property type="entry name" value="HTH_LACI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50932">
        <property type="entry name" value="HTH_LACI_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH lacI-type" evidence="5">
        <location>
            <begin position="35"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PJN12490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="377" mass="39855" checksum="1B39B9D83C7B00C0" modified="2018-04-25" version="1">MTQQSAAGRSTARTRQPVDGGQSGTRPVQSHPVTARLADIAAQAGVSEATVSRVLNGKPGVAAATRQSVLAALDVLGYERPVRLRQRSAGLVGLITPELENPIFPALAQVIGQALTRQGYTPVLATQTPGGSTEDELTEMLVDRGVSGIIFVSGLHADTSADMQRYEQLRAQGVPFVLVDGFSPKVQAPFISPDDRAAMKLAVTHLVSLGHTRIGLALGPKRFVPVQRKIEGFVRTMQDLLPLSAEEIERDLVQHSLYTLEGGQAAATALIDRDCTAVVCASDMMALGAIRAARQRGLDVPSDVSVVGFDDSPLIAFTDPPLTTVRKPVPAMGQAAVRTLLEEIGGTPAPHSEFVFMPELVVRGSTASAPGDRVPRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K137</accession>
    <name>A0A2M9K137_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Antibiotic biosynthesis monooxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_07430</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000002">
        <property type="protein sequence ID" value="PJN12834.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN12834">
        <property type="protein sequence ID" value="PJN12834"/>
        <property type="gene ID" value="CG723_07430"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007138">
        <property type="entry name" value="ABM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03992">
        <property type="entry name" value="ABM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABM" evidence="1">
        <location>
            <begin position="28"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="domain" description="ABM" evidence="1">
        <location>
            <begin position="144"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN12834.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="223" mass="23682" checksum="31CA0B83A24B124E" modified="2018-04-25" version="1">MTARTTGHPDPARADAGLAFFSTWRVGSPERAKAAIDAIAHAWEGRPWPHAGLLSYSVHEGVGTDEGTLMHHSQWRDEAAYDDFFRGLSDSAGNGRDERNAEIDAAVPGIERLGLYRTRRYRSGGLADPDAVPGLIVLTRTAFDAPDADRQRAWVDAVFGAAEGGGPLSSGDVRAHFHLSLDGATVVTYAEWAGAEAHDAALTVPGLTGRYRLALSLVPGPAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K1K2</accession>
    <name>A0A2M9K1K2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Short-chain dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_06685</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000002">
        <property type="protein sequence ID" value="PJN13011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN13011">
        <property type="protein sequence ID" value="PJN13011"/>
        <property type="gene ID" value="CG723_06685"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN13011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="307" mass="31040" checksum="01597E88DB1D988B" modified="2018-04-25" version="1">MGAGAGSGLCAGRVAIVTGAGRGLGRAHALAFAAEGARVVVNDLGVGLDGAPAPDSPAAQVVEEIRALGGEAVAHGGDIATTEGAASLVATALDTFGRLDTLVNNAGFLRDRMLVNLDEDDWDAVMRVHLKGHFLPLKHAAAHWRAEAKAGRTPSARVVNTSSGAGLLGSVGQGNYSAAKAGIVGLTLVAAAEMGRYGVQVNAVAPAARTRMTERTFADTMAAPEDGFDAMAPENVSPVVVWLGSAASDGVTGRVFEAEAGRITVMEGWRPGPTADKAARWTPAEAGEAARELLGRAQVPGAVYGSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K1U1</accession>
    <name>A0A2M9K1U1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CG723_00335</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000001">
        <property type="protein sequence ID" value="PJN13089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN13089">
        <property type="protein sequence ID" value="PJN13089"/>
        <property type="gene ID" value="CG723_00335"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.4080.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005502">
        <property type="entry name" value="Ribosyl_crysJ1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036705">
        <property type="entry name" value="Ribosyl_crysJ1_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03747">
        <property type="entry name" value="ADP_ribosyl_GH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101478">
        <property type="entry name" value="SSF101478"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PJN13089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="302" mass="31941" checksum="EFB501AA6D620CAD" modified="2018-04-25" version="1">MTADSSPHVRLDRALSSLRGLAVGDALGSQFFVPANHPLLKRRELPDGIWQWTDDTEMACSVVAVLAAENRIEQDALARSFAEHHDFDRGYGPAVNRLLRQIREGGDWRSLSSALFKGQGSWGNGAAMRIAPLGAWYADDPEQATHQAEISAYPTHQHREAVVGAMAVAAAAAIVADPAGPPTPQALLDGVIALVPRSAVGAGLRRARDMLDYGDPGTVAAVLGCGRRTTAHDTVPFALWSAARGLGDFERAFWETAQVGGDMDTTCAIVGGVVASGLGGAPADLWLQRTEPLPEWAPGLPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K2H5</accession>
    <name>A0A2M9K2H5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycosyl transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_01710</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000001">
        <property type="protein sequence ID" value="PJN13322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN13322">
        <property type="protein sequence ID" value="PJN13322"/>
        <property type="gene ID" value="CG723_01710"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_2-like" evidence="1">
        <location>
            <begin position="12"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN13322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="286" mass="31773" checksum="1BC2DEC6A8121CD5" modified="2018-04-25" version="1">MQQHSTRTPLVSVVVTCFNYDRMLLRALESVRAQTTADWELVIVDDGSTDTSRDVAQTFAAAHPELAVTLVLTRNGGLGRARNLGISVARGRYVACLDADDHYEPHALEKLSAALDRDPTAEVARPYLLSFGVEERIWEYPDYDFDASTSVNQAPYCAMFRRSAWQRAGGYHEGLPAYEDWNFWIAVGKHGGHMTTVPEPLLHYRTSVDGMFARHRVHDLALRAAIVTNHPDVYDSSCQRLARRILAGENVDDDLKAGPPHAIFALSYPARTLRGEDISADFGAVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K2W3</accession>
    <name>A0A2M9K2W3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Aspartate aminotransferase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_02525</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000001">
        <property type="protein sequence ID" value="PJN13463.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN13463">
        <property type="protein sequence ID" value="PJN13463"/>
        <property type="gene ID" value="CG723_02525"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044249">
        <property type="term" value="P:cellular biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="CDD" id="cd00610">
        <property type="entry name" value="OAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005814">
        <property type="entry name" value="Aminotrans_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00202">
        <property type="entry name" value="Aminotran_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000521">
        <property type="entry name" value="Transaminase_4ab_Lys_Orn"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="1 2" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN13463.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="428" mass="45861" checksum="BA9B7174BBDC29C4" modified="2018-04-25" version="1">MTPDLHARHRAVLPDWLALYYDRPIEITHGEGRHVWDAAGNKYLDFFGGILTTMTAHALPEVTKAVSEQAGRIIHTSTLYLNRQMVELAERVASLSGIPDARVFFTTSGTEANDTALLLATAYRRSNQILAMRNSYHGRSFSAVGITGNRGWSPTSLSPLQTLYVHGGVRSRGPYAQLTDAQFIEACVDDLRDILGQTRGVAALIAEPIQGVGGFTSPPDGLYAAFREVLQEHGILWIADEVQTGWGRTGEHFWGWQAHGQNGPPDILTFAKGIGNGMSIGGVVARAEVMNCLDSNSISTFGGSPVTMAAGLANLIYLLEHDLQGNARRVGGLLIERLRAVGATTESVREVRGRGLMIGIELVKPGTDEAYPDAAARVIEAAREGGLLIGKGGGHNTSVLRIAPPLTLTVAEAEEGAAILERALHSVC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K2X7</accession>
    <name>A0A2M9K2X7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Alpha-1-antitrypsin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CG723_02260</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000001">
        <property type="protein sequence ID" value="PJN13420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN13420">
        <property type="protein sequence ID" value="PJN13420"/>
        <property type="gene ID" value="CG723_02260"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13519">
        <property type="entry name" value="VWA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00327">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="SSF53300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50234">
        <property type="entry name" value="VWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014889859" evidence="2">
        <location>
            <begin position="30"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="391"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="domain" description="VWFA" evidence="3">
        <location>
            <begin position="42"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PJN13420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="423" mass="44650" checksum="4CA51C1E9B3A801F" modified="2018-04-25" version="1">MIIRKRLAAGTCVLFAALTMGLTPVGASAADNPDGQPTAAPKVELVLDVSGSMRARDIDGGTRMAAAKQAFNEVLDATPKEVELGIRTLGANYRGEDRKVGCKDTAQLYPVGPLDRTEAKTAVATLSPTGWTPIGPALLKAADDLDGGDGSRRIVLISDGEDTCQPLDPCEVARDIAAKGINLTIDTLGLVPDAKTRDQLSCIAEATGGTYTSVRHTDELTDRVGQLVDRAADPVVNPVAVEGAKECTGAPEVKPGLYTDRETFGEHRFYRVAVAPGQELRASVSVAADRAVNKDYGVLLRAVTEHGREIVRGSEAGDGRTDVISTGLRYPKPEQDDDEAAAETVCLQVSNSYSAPASVKTTPGLPVELTVDVVDAPSAASDVAAFGLGRGWWLLGALVLTGFVAGVLWGWISRWRFAVWRTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K3K8</accession>
    <name>A0A2M9K3K8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CG723_03960</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CB01635</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000001">
        <property type="protein sequence ID" value="PJN13702.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN13702">
        <property type="protein sequence ID" value="PJN13702"/>
        <property type="gene ID" value="CG723_03960"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="36"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="92"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="123"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="150"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="203"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="245"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="84"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PJN13702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="287" mass="30887" checksum="BB615900252AC2F2" modified="2018-04-25" version="1">MSQSTLPATPAKTAGVADRQGPSLGRRAADVAERSWRPVALLVVCFVAWWVIAAAELVEPYLVPSPGRTLDVILDKPDYLWQHTWVTTYETLLGFVIAVGVGIFSAVIMVYSSTVEKTLYPILLFAQVVPKIAIAPLFVVWLGFGIAPKILIAVLIAFFPVVISMVTGLKAVDPEMLQLSATMGASPWQTFRKIRFPASLPHLFSGLKVAVTLAVTGAVVGEFVGANEGLGYVILQANGNLDTPMLFAGLLVMSLIGVVLFVLVEIAEKLLLPWHASRRDVAATTAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K3T9</accession>
    <name>A0A2M9K3T9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CG723_02905</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CB01635</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 3">Belongs to the DedA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000001">
        <property type="protein sequence ID" value="PJN13782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN13782">
        <property type="protein sequence ID" value="PJN13782"/>
        <property type="gene ID" value="CG723_02905"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032818">
        <property type="entry name" value="DedA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032816">
        <property type="entry name" value="SNARE_assoc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30353">
        <property type="entry name" value="PTHR30353"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09335">
        <property type="entry name" value="SNARE_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014935562" evidence="4">
        <location>
            <begin position="19"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="32"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="125"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="152"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU367016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PJN13782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="183" mass="19357" checksum="FD197D5CF801D12A" modified="2018-04-25" version="1">MIGALVPVIPTGALVSSAAVVAFHQTAPFSLLLVFGVSAFAAFLGDVALYWLGQRGMDSRNGSKWLAAIRDRAPEERLAQAQDKLADHGVMVLVLSRLVPAGRIPVMLACLMARMPLRQFARGDVPACLAWAVTYQLIGILGGSLFSEPWEGVVAAVGLTLVISAAPAVWRRARGGRSDGQHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-05-25" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K3V5</accession>
    <name>A0A2M9K3V5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">LacI family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CG723_03905</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000001">
        <property type="protein sequence ID" value="PJN13811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN13811">
        <property type="protein sequence ID" value="PJN13811"/>
        <property type="gene ID" value="CG723_03905"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01392">
        <property type="entry name" value="HTH_LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000843">
        <property type="entry name" value="HTH_LacI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046335">
        <property type="entry name" value="LacI/GalR-like_sensor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00356">
        <property type="entry name" value="LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13377">
        <property type="entry name" value="Peripla_BP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00036">
        <property type="entry name" value="HTHLACI"/>
    </dbReference>
    <dbReference type="SMART" id="SM00354">
        <property type="entry name" value="HTH_LACI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50932">
        <property type="entry name" value="HTH_LACI_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH lacI-type" evidence="4">
        <location>
            <begin position="13"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PJN13811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="364" mass="39190" checksum="33D91F12ACEB6129" modified="2018-04-25" version="1">MPRQGSTANGRRATVVDVARLAGVSTATVSRVMNRNYPVAAATRERVEEAMRELGYVVNAHARALAGVSGRTVGIIISDVVDPFYAYIARGVEREATAGGRLCLVCSTQGDPQRELAFIELMHERRADAVILVGGSVADRGYRTELARRARELDAGGSKLVLCGRPSLGKDAPTVGVEYDNEGGAFAITDHLLTEGHERILYLGGPPGLSTTKERIAGHRRALEQRGLPRDPALVQPGAFSRQFGHRRMTELLRDGPEFTAVFAANDIVAAGAAQALEEAGMRVPQDVSLVGYDDVPVAQELRPRLTTVHIPLEEMGRQAVRVALAGGDEDDWRAPTTGTLRLGTHLVVRDSVAAPRGGRRRRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JEU9</accession>
    <name>A0A2M9JEU9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_45130</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000050">
        <property type="protein sequence ID" value="PJN05399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN05399">
        <property type="protein sequence ID" value="PJN05399"/>
        <property type="gene ID" value="CG723_45130"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025326">
        <property type="entry name" value="DUF4232"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14016">
        <property type="entry name" value="DUF4232"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014702581" evidence="2">
        <location>
            <begin position="22"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="34"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="56"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN05399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="241" mass="24247" checksum="F15BA361CBBE0855" modified="2018-04-25" version="1">MAAPTRSRVRLLTAAATVALAALSLTACNNGDGVRDEGASQHPSNSVPADGDNGKDANAGSTTGSGTGTGTSSGTGSTATTKPKPQPASTGKNNPTASTARVTCNGSTVKVAAQSVSRPINHMLLTVTNTGSKRCDLYGYPAVRFGEAQAVPPVIDDSQPQAVVSLSPGRSAYAGVALSGGDDGGGSNGRTENTLEVFFQGRNTNDGGPGAKAALPAKGVYIDDSLKVTYWQQSMSDALSW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JFC5</accession>
    <name>A0A2M9JFC5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Sugar permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CG723_44060</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CB01635</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000045">
        <property type="protein sequence ID" value="PJN05579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN05579">
        <property type="protein sequence ID" value="PJN05579"/>
        <property type="gene ID" value="CG723_44060"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="79"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="113"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="146"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="190"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="245"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="75"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PJN05579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="280" mass="30776" checksum="80B1873D022CC626" modified="2018-04-25" version="1">MPRSALSRPTRANLIALPLLIVVGLVWIYPFLWIVTGAFKTQSGLFTGGASLIPDQWNFDNFQRAWVDAGFSKYFFNTVVYAVVSTLIELFKSALCGYVLARYDFPGRKLLHRMIVATLFVPVASIVIPQFVLVDNLGLLNTRAGVILAMSGAAGALYVLLFIGFFSGVPKDLFDAAKLDGAGFLRTFRLVLPLAKPVIAVVVIFQFISNWNEFNIPLVFTLGQPDLQNLAVGMLSFKGEHSVDWTGFAAGMTLSVIPMLLVFVFFQSYFVRGLAGATKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JFC7</accession>
    <name>A0A2M9JFC7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">RNAse</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_44195</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000046">
        <property type="protein sequence ID" value="PJN05522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN05522">
        <property type="protein sequence ID" value="PJN05522"/>
        <property type="gene ID" value="CG723_44195"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.380.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007295">
        <property type="entry name" value="DUF402"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035930">
        <property type="entry name" value="FomD-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04167">
        <property type="entry name" value="DUF402"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF159234">
        <property type="entry name" value="SSF159234"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF402" evidence="1">
        <location>
            <begin position="36"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN05522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="148" mass="16744" checksum="B03DC285753C8EFF" modified="2018-04-25" version="1">MVWLGEDEYGVWLGSPIGTIYGKGEECEVYATQERRVTLFPRDGWWTALFQEAPARLDVYCDDTTPSEWPHPGEVTMVDLDLDVCRTRGDRSVSIVDEDEFASHQEAYGYPSHVISHARSAAESLSAALRESVEPFNARFRVWLAQVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JFE9</accession>
    <name>A0A2M9JFE9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Protease inhibitor protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CG723_43840</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CB01635</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the protease inhibitor I16 (SSI) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000044">
        <property type="protein sequence ID" value="PJN05626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN05626">
        <property type="protein sequence ID" value="PJN05626"/>
        <property type="gene ID" value="CG723_43840"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004867">
        <property type="term" value="F:serine-type endopeptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.350.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000691">
        <property type="entry name" value="Prot_inh_I16_SSI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020054">
        <property type="entry name" value="Prot_inh_SSI_I16_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023549">
        <property type="entry name" value="Subtilisin_inhibitor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036819">
        <property type="entry name" value="Subtilisin_inhibitor-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00720">
        <property type="entry name" value="SSI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00294">
        <property type="entry name" value="SSBTLNINHBTR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55399">
        <property type="entry name" value="SSF55399"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00999">
        <property type="entry name" value="SSI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5 8" id="KW-0646">Protease inhibitor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="6 8" id="KW-0722">Serine protease inhibitor</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014832020" evidence="9">
        <location>
            <begin position="32"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="domain" description="SSI" evidence="10">
        <location>
            <begin position="38"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00720"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PJN05626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="145" mass="14739" checksum="413B5E4C5795C30E" modified="2018-04-25" version="1">MRTNMRFAATAATATALIGGALIATSVTATAAPASLYAPSALVLTVSQPGGSTDTAARAVTLSCMPGASGTHPNPAAACADLRAADGRPDSLLSTTHGQACTRLWSPITVTVDGVWQGTRTSWKHTFANSCEMNNTVGQSSLLNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-06-02" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JFM3</accession>
    <name>A0A2M9JFM3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">DNA-binding response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CG723_43565</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000043">
        <property type="protein sequence ID" value="PJN05689.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN05689">
        <property type="protein sequence ID" value="PJN05689"/>
        <property type="gene ID" value="CG723_43565"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00383">
        <property type="entry name" value="trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="44"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="domain" description="OmpR/PhoB-type" evidence="5">
        <location>
            <begin position="169"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="3">
        <location>
            <begin position="169"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PJN05689.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="272" mass="30343" checksum="0E687768AA0241AE" modified="2018-04-25" version="1">MRFSGNSQVVESRFSERARRVCNMTATSPQGRTELLRPDGTPVRVLVVDDEQAITELLSMALRYEGWQIRSAGDGMGAVQTAREFRPDAIVLDMMLPDMDGLSVLGRLRREHQDVPVLFLTAKDAVEDRIAGLTAGGDDYVTKPFSLEEVVARLRGLIRRSGAADRRSESVLVVGDLTLDEDSHEVSRGGDGIHLTATEFELLRYLMRNPRRVLSKAQILDRVWSYDFGGQANVVELYISYLRRKIDAGREPMIHTRRGAGYLIKPAVPVAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JFP7</accession>
    <name>A0A2M9JFP7_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HTH tetR-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_43980</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000045">
        <property type="protein sequence ID" value="PJN05567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN05567">
        <property type="protein sequence ID" value="PJN05567"/>
        <property type="gene ID" value="CG723_43980"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023772">
        <property type="entry name" value="DNA-bd_HTH_TetR-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039536">
        <property type="entry name" value="TetR_C_Proteobacteria"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14246">
        <property type="entry name" value="TetR_C_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01081">
        <property type="entry name" value="HTH_TETR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="15"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="38"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN05567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="210" mass="23048" checksum="6059ADB1F19189CE" modified="2018-04-25" version="1">MRTWAENDPKARLMARKREAIINAALAAFLEEGYGGSSVNRIAASAGVSITTLYRHFDSKDDLFVAVIQEACDTSAQTADPEWVNLPPLEGLTEAGCDLLQHILSEQQLALFRVVARDAQRFPELGRRYQQEILGDRIALFTRHLSHWSAELRSKVSDPTRAAHVFSALLQAEIMDTALLGGPVPDSAAIRIRSQEAANDLLALAEAGRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JFU5</accession>
    <name>A0A2M9JFU5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Glycosyl transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CG723_42795</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000041">
        <property type="protein sequence ID" value="PJN05766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN05766">
        <property type="protein sequence ID" value="PJN05766"/>
        <property type="gene ID" value="CG723_42795"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044249">
        <property type="term" value="P:cellular biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901576">
        <property type="term" value="P:organic substance biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028098">
        <property type="entry name" value="Glyco_trans_4-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13439">
        <property type="entry name" value="Glyco_transf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_4-like_N" evidence="4">
        <location>
            <begin position="13"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="domain" description="Glycos_transf_1" evidence="3">
        <location>
            <begin position="202"/>
            <end position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PJN05766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="422" mass="46266" checksum="F849FE3783A9A1E2" modified="2018-04-25" version="1">MQISFLIHNAYGIGGTIRTTYNLANTLAEQHDVEVVSVLRHRDDPVFRPDPRVRVRHLVDIRKGTPGYEGGSPEYRTPATTFPRAEGRYDQYNALTDRRIAEHLRAVDADVVVGTRPGLNVHLARQTRRGPLRVGQEHLTLDSHPTALRRQLRAVYPRLDALTTTTEADARAYRAKMRLPGVRIEAVPNPVPAPGVEPADGSGKWVVAAGRLAPVKRYDLLVRAFDQVRAERPDWRLRIYGSGKQKDKLRALIDDLGLYNHVFLMGPAHPIEPEWAKGSIAAVTSSLESFGMTIVEAMRCGLPVVATDCPHGPGEIIDNGVDGRLVEVGNVEAISGGLLELINNDALRARMASAALKDSERFDPAHIAERYESLFGSLTARRGGDLLHRTRGALLGGAYAVRDAGRSAFTAQGTSQRKGRTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-09-29" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JG82</accession>
    <name>A0A2M9JG82_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Helicase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_41955</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000038">
        <property type="protein sequence ID" value="PJN05901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN05901">
        <property type="protein sequence ID" value="PJN05901"/>
        <property type="gene ID" value="CG723_41955"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006935">
        <property type="entry name" value="Helicase/UvrB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005114">
        <property type="entry name" value="Helicase_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03457">
        <property type="entry name" value="HA"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04851">
        <property type="entry name" value="ResIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0347">Helicase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="1">
        <location>
            <begin position="27"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN05901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="861" mass="92921" checksum="61B393DB03D7DEFC" modified="2018-04-25" version="1">MAAMKLLPHQVEAVDGILRELQKPTDGNMPTQGLRAQVVSATGSGKTLMAVEAARRLKARRVLVLVPTLDLLMQTAAAWRAGGRGGAMVGVCSLSAADSQGVPCTTSAEELRLWLRGLEQVTVFATYASLGLRTLQRAHGAGVGVWDLVVVDEAHRTSGDAGKPWAAVHDQRQIPAQRRLYMTATPRVWEAGGEMPGMVASMDRDSELFGPVAYELKLSEAIRRGIVAPYQVVCVDIRDEDVHQALQGEPLGSDHVRGARLAALQTGLLTAAVEEKLRRILTFHSRVAEAEAMAAGVPAVAEQLHADDPDRFPAAGRVWAQWLYGEHSPGHRQAVLQEFASDFIWARGEGGQGCGGREVKAAVQVLGSVKVLGEGVDTARCDAVAFCDARGSMVDIVQMVGRALRIQPGEGKLATLVVPVFLGPGEEGGEMLVSNSYDTLSKVLGALRAHDTETIEALADPRVRSGSWVQDGDQGEVVEGAVDEQGDSGEDVAGGEGAEPVVSGPAAELLKFSTPRDPALIAQFISLRIIDPENSYWRRGIQAAIQYLKESGAQVLQVPQRYVTPDDWSPARFPLGVWLADQRKHYNAELLEGERVRQLDKLGMVWNAHDNAFDEGLAHARAWAEEHGHLLAPVGAVGEGGFPVGVWLKNQRAAARQAVEAALAYEQGQLVPAGGWGLSESRQDALDAIDPGWCPTWDTGWQRCFRLAKNHIDAGGILPREAGVLVVQGEDLGVWVKAQRLGWDKLGAAQQWLLESVLGVEEAGEDERPVRRTQDDKWMLNLAAARRFHAREGHLQVPRKHIEQVSVEEAGHGAAGVEAGSRAGVEGVPVALGMFLANTRRRADKLTPQRRADLEALGMRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JG92</accession>
    <name>A0A2M9JG92_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_41975</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000038">
        <property type="protein sequence ID" value="PJN05905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN05905">
        <property type="protein sequence ID" value="PJN05905"/>
        <property type="gene ID" value="CG723_41975"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="54"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="61"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN05905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="80" mass="8880" checksum="23491FBC8C951DF1" modified="2018-04-25" version="1">MDDERELADAVEVLKDAEDRVADALRVYLARDPVTGRPVHGRIGRAAQITGWGEQRVKETATPALAERRRARRSDKGVGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JGK3</accession>
    <name>A0A2M9JGK3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_41860</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000037">
        <property type="protein sequence ID" value="PJN06011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN06011">
        <property type="protein sequence ID" value="PJN06011"/>
        <property type="gene ID" value="CG723_41860"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="23"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="66"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="114"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="141"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="239"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="262"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="287"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="316"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN06011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="503" mass="52771" checksum="6F4AF38A76EA9EE2" modified="2018-04-25" version="1">MLKRVFVAPDPGRLRLRFAARGVLGISLAVALCGLAGHSLVAAITGGLAALLALFTVTDATVRGQAVTTALLPAVGLPVLGLAATLHDVPVARDLAFLAVVGAGVYARRWGPRGHSLGVFAFMTFFAAQFLHTVPEQLPELYAAVLLSLAAASVVRFGLWCYERRLPAPAAVAAPTCGSRLARITTRQAVQATVGAGFALAAGQVLSDQRWYWAVGATWWVFVNTTSRGETVVRGFRRFLGTVLGIVLGFAVAVPLHDQPVAAAVIVALSVFGIFYTAAVSYTWMMLAVTVMASMLYGLLGVLDPALLALRVGETAVGALGAVLAVLLVLPVTTHSVTDAWVERALRCVHACTAEAAARLAGSPTADPARRVAELESILGRVRLSLAPLVHPFSPMRARMGRARHVLALLDDCAREVRGLASVVADPEASHDARLAAACWRVEAAVEALTDTPAGGARRRTESATLPQLVEGEPVLAHLHALEQALLELAVPLRGSNRVPVSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JGU8</accession>
    <name>A0A2M9JGU8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_41765</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000037">
        <property type="protein sequence ID" value="PJN05977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN05977">
        <property type="protein sequence ID" value="PJN05977"/>
        <property type="gene ID" value="CG723_41765"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013211">
        <property type="entry name" value="LVIVD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08309">
        <property type="entry name" value="LVIVD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014741141" evidence="2">
        <location>
            <begin position="36"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="32"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN05977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="500" mass="53602" checksum="DAC12EC4171B3A2A" modified="2018-04-25" version="1">MTLLDTSRTRRRRLGVATTAAGLLAALLMGSPAAATPDPGDTPARSERLSKSAAADTRAAIANGDIPAQDEVVHSDNIEHLTNIPKDVLPGFNSDLAFQGRYAFAGNYDGFRIFDISNPKAPKTVAQVLCPGSQNDVSVSGDLLFLSTDSSRSDNSCASTTQPATEKSSWEGMKVFDISDKRNPKYVAAVETACGSHTHTLVPEKKNVYVYVSSYSPSATFPDCQPPHDGISVIKVPRKAPEKAATVNFPVLFPGEGPDGGGNPGGPTNPGVSKTTGCHDITVLPSKDLAAGACMGDGILFSIKDPENPKVIDQVEDNTNFAFWHSATFNQKADKVIFTDELGGGGAATCNEAVGPDRGADGIYAVVGKGDHRKLVFKSYFKIPRHQADTENCVAHNGSLIPVKGKDIMVQAWYQGGVSVWDFTDSSKPKEIGYFERGPLTTDTLQVGGAWSAYYYNGYIYSNDIAKGFDVLKLSDRRTDPAERVRMGELNVQTQPDYFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-09-29" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JGV7</accession>
    <name>A0A2M9JGV7_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HTH cro/C1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_40925</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000035">
        <property type="protein sequence ID" value="PJN06111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN06111">
        <property type="protein sequence ID" value="PJN06111"/>
        <property type="gene ID" value="CG723_40925"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="2">
        <location>
            <begin position="215"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="116"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="126"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN06111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="367" mass="39620" checksum="9DB18E87DC4F6575" modified="2018-04-25" version="1">MHPRKGLRTMSASDQWPTSCANPGCYNTVEQAVRSGRRRRYCSDRCGRSYRKRQLPDPGGTSAREYAAQVADECAQILDAVVAHAEGSQPLAALRRLAQLHIDLKDLTSALVEQARSDKKKSSEIASAMRATSDTISRQYSAADNARRRQSRLSRLQNPQAAPLPTRSRTVPHQRTLRAAAGAEQGAAGADDATADSVSTFGRALSHLHRSSDKSMRVLGEEAGVSASYVSRIMSGDRLPTWGVTRRLVRALDASPEDLRPLWDAAHGQKPPSPDSLSAALRGLRLANAHPSFRQLSARINHSLSPGEIAAVIEGDQVPDWEQVEHLVAALHGRPESVLPLWNAAAVTPEARNRSAFSSGLPAGAFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JGW9</accession>
    <name>A0A2M9JGW9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_41030</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000035">
        <property type="protein sequence ID" value="PJN06128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN06128">
        <property type="protein sequence ID" value="PJN06128"/>
        <property type="gene ID" value="CG723_41030"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN06128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="251" mass="28309" checksum="AEBC8FDB7AD2F67A" modified="2018-04-25" version="1">MPEIVWTATSAIATTAALWVIAWQAILTRRGVDIQSAVALDSARARLDSQAPDVVVQLEDPSWPPLAWSHMGLPVNPWPNGQIWYFPEKEHERIVLQTEVIVRHFYSGRLEVTFAGDLVDDHDGRARRAQPVLLAGDGEHSVLLHKDFTIKQLSENYHAQQEGRCLPHRVQGTVTVHDGRDNGVTDTWSLDLTGCPIQPHESRDGAWVVVPDHLTDGTGLRSLVYIRRPARRRTYWISRQDGLELPAPRYT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-06-02" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JHE6</accession>
    <name>A0A2M9JHE6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_40415</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000033">
        <property type="protein sequence ID" value="PJN06282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN06282">
        <property type="protein sequence ID" value="PJN06282"/>
        <property type="gene ID" value="CG723_40415"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="89"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="92"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN06282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="148" mass="15979" checksum="28D0FBC8EB5CB76B" modified="2018-04-25" version="1">MATWGLIVEMTVGTGERKHMEASVLGHVEGSREQALAELAEWIGRYTPEHPRSPKRSRIFRTADGFLLVIDGAWQSFSSRFTVAELVKDSAAPPPEPQPTPVPTPEDTAAPTAAPPENAAQAPSGPTVDRYEDGVPVKPAWLGRTDLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JHN6</accession>
    <name>A0A2M9JHN6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_39725</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000031">
        <property type="protein sequence ID" value="PJN06389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN06389">
        <property type="protein sequence ID" value="PJN06389"/>
        <property type="gene ID" value="CG723_39725"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007995">
        <property type="entry name" value="DUF742"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36221">
        <property type="entry name" value="PTHR36221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05331">
        <property type="entry name" value="DUF742"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN06389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="143" mass="15344" checksum="098FCC3ABA00075C" modified="2018-04-25" version="1">MNDHGHRDDQGRGSPDRSGSQWYDNEAGPLVRPYAMTGGRTSPGPRGVRFDLIALVKLDDAAPGKDDDTALGPEHRALIELCRTETQSVAELAAGTDLPVGVVRVLLGDLLDMGCVKVSRPVPPAQLPDEKILREVIDGLRAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JHW3</accession>
    <name>A0A2M9JHW3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_38655</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000029">
        <property type="protein sequence ID" value="PJN06469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN06469">
        <property type="protein sequence ID" value="PJN06469"/>
        <property type="gene ID" value="CG723_38655"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="55"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="87"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="121"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="176"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="216"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="251"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="312"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="344"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="392"/>
            <end position="414"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN06469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="431" mass="44520" checksum="E39C1EBD4701ECBC" modified="2018-04-25" version="1">MSEQASDGRSGTRRSAKHGWAAALMAVLAGLVAMVVTAALGLWAAGATGLPGSAFPRVVAAVVVMAAGGSVDLAGNAGELAQTHADISVLPLSVTLAGALVIAAGFLRPLRHRAIASSGELLGWAGRVAVPWVVALIVLSLLARQDFAIPVTDPTGGIIEGVLDGAPKVGFRTNMALTLLFGLLWLAGVMILAVLVSRGAPLPARLVRFQESVRPAAYAMVALLLVYVALGVVIGLVVAATRGHAAETFAVILLGLPNLVWFAYTIGLGASWDGKVDGPFGLPVPHILDVVLRTPDISTVNVSTLAEQDDRIWWSVAVAAILTLAAAFAMALRSPARMRAWQHALHMAVALVLTVLAVCLLARISARYGLSLLGIGDIGGGLGGEVALRPKLWTALGLAVLWGLVTGFLGGLLASRLHRRGEVETAQPDRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JI09</accession>
    <name>A0A2M9JI09_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NTP_transf_9 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_38725</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000029">
        <property type="protein sequence ID" value="PJN06482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN06482">
        <property type="protein sequence ID" value="PJN06482"/>
        <property type="gene ID" value="CG723_38725"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.150.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007361">
        <property type="entry name" value="DUF427"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038694">
        <property type="entry name" value="DUF427_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04248">
        <property type="entry name" value="NTP_transf_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NTP_transf_9" evidence="1">
        <location>
            <begin position="16"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN06482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="107" mass="11791" checksum="9A3DA44A71AB64D9" modified="2018-04-25" version="1">MADGHTITIEQGTGSVRVVHGGVVLAQSARPLLLRETGCPVRYYIPPADVRTDLLTPSDTQTYCPFKGTASYWSLPDAPDLVWAYPDPKPDVAEIKDHLCFYEVETV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JI22</accession>
    <name>A0A2M9JI22_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">GNAT family N-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CG723_38895</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000029">
        <property type="protein sequence ID" value="PJN06510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN06510">
        <property type="protein sequence ID" value="PJN06510"/>
        <property type="gene ID" value="CG723_38895"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PJN06510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="216" mass="23315" checksum="5C3BFAD209D1E270" modified="2018-04-25" version="1">MPGTVRDILDAAARGVFPPPDGGTTVVPQADHRDAGVLSFTAHSVVFTDEDPQWVHETLRGLDCDPLAATMNPRFLGALMERTGRRHDTTDLLTVAPALPGEPPVALKEIADPDHPRVVRARLRRDDVRMWAADGGVLVLGRGVAGRWETAIEVDEEARHRGLGRLLAVAARHLVPDGGPLWSQQSPGNARSVRAFQAAGYRPVGAEALFIAPCRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JIC0</accession>
    <name>A0A2M9JIC0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Daunorubicin/doxorubicin resistance ABC transporter ATP-binding protein DrrA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CG723_38505</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000028">
        <property type="protein sequence ID" value="PJN06592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN06592">
        <property type="protein sequence ID" value="PJN06592"/>
        <property type="gene ID" value="CG723_38505"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043215">
        <property type="term" value="P:daunorubicin transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1900753">
        <property type="term" value="P:doxorubicin transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005894">
        <property type="entry name" value="DrrA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025302">
        <property type="entry name" value="DUF4162"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13732">
        <property type="entry name" value="DUF4162"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01188">
        <property type="entry name" value="drrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="6">
        <location>
            <begin position="5"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="314"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="37"/>
            <end position="44"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PJN06592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="337" mass="36293" checksum="5D7A71D350EBEA6E" modified="2018-04-25" version="1">MPGAIYAEGLVKTFGDVKALDGVDLDVPEGTVLGLLGPNGAGKTTAVRCLTTLLTPDSGKAVVAGIDVLKHPNEVRRSIGLSGQFAAVDEYLTGRENLQMVGQLYQMKAKEAKARASELLERFNLTDAADRTSKTYSGGMRRRLDLAAALVVSPPVMFMDEPTTGLDPRNRLQLWEVIQELVAGGTTLLLTTQYLEEADHLAHDICVIDHGRVIARGTSDQLKAQTGGERVELVVHEREHMTPAAEVLAGFGKGETTVEQHTRKLTVPVSGGAKLLAEVIRELDTRGIEIDDIGLRRPTLDDVFISLTGHVAEEKEDENGSGAGAARQSKRKKEAVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JJ12</accession>
    <name>A0A2M9JJ12_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">ABC transporter substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CG723_36885</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000025">
        <property type="protein sequence ID" value="PJN06859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN06859">
        <property type="protein sequence ID" value="PJN06859"/>
        <property type="gene ID" value="CG723_36885"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007210">
        <property type="entry name" value="ABC_Gly_betaine_transp_sub-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04069">
        <property type="entry name" value="OpuAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014741142" evidence="2">
        <location>
            <begin position="21"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="domain" description="OpuAC" evidence="3">
        <location>
            <begin position="46"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PJN06859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="311" mass="32599" checksum="F56C5C4C240EBF93" modified="2018-04-25" version="1">MNRRTVIGGLFAAASVPALAACSGGITSLDGQGSGGGGGGSSKNGVTIGTANFTENQVLGYLYAAALEAAGVKTKVRPNLGTREILIPALEGGDIDLLPEYQGALLHYLDPKSTATEEGEMQNALAVALPKGLQILPYGLAEDSDAFVVTAETAKKYKLTSLADLAEHNGKLVIGAAPEVKKRQVGAVGLKDVYGVEFKEFKSLDSSGPLVKGALKKGDVDVANLFTTDTDIVDNHWVVLTDPKNLVPGQHVVPLVADRKADSTVRKALARLGNVLTTEQLTELNRQVDKDKKDPEDVADAYARQHGISKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-09-29" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JJ70</accession>
    <name>A0A2M9JJ70_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">TIGR03089 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CG723_37075</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000025">
        <property type="protein sequence ID" value="PJN06892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN06892">
        <property type="protein sequence ID" value="PJN06892"/>
        <property type="gene ID" value="CG723_37075"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017523">
        <property type="entry name" value="CHP03089"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03089">
        <property type="entry name" value="TIGR03089"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PJN06892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="251" mass="25994" checksum="45C453DA10BDBEAD" modified="2018-04-25" version="1">MNATDRTPADLLRSALAADPGRPLVTFYDDATGERVELSVATFANWVAKTANLLQGDLAAQPGDRLALLLPAHWQSAAWLLACASVGVVADVGGDPAAADIVVSGPDSLDKARACSGERVALALRPLGGRFPQPPEGFVDYAVEVPGQGDRFAPFAPVDPEEPALVVAGAEFTGAEVVEKARADAADLGLTGPGSRLLSGLPYDTWRGLSAGLYAPLATGGSVVLCRHLDGLDEDSLAKRVENERVSATAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JJM0</accession>
    <name>A0A2M9JJM0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CG723_35710</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CB01635</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ABC transporter superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000023">
        <property type="protein sequence ID" value="PJN07079.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN07079">
        <property type="protein sequence ID" value="PJN07079"/>
        <property type="gene ID" value="CG723_35710"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031460">
        <property type="term" value="P:glycine betaine transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005892">
        <property type="entry name" value="Gly-betaine_transp_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="SSF54631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01186">
        <property type="entry name" value="proV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0129">CBS domain</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="6">
        <location>
            <begin position="2"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="7">
        <location>
            <begin position="306"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="35"/>
            <end position="42"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PJN07079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="382" mass="42017" checksum="A844D12C8E34E6D3" modified="2018-04-25" version="1">MIRFEHVTKRYADGTTAVDDLSFEVNEGELVTLVGPSGCGKTTTMKMVNRLIEPSEGRIFLDGDDISGIDPVQLRRRIGYVIQQVGLFPHKTVLDNTATVPHLLGVKRAKARERAAELLDLVGLDPRTFGDRYPDQLSGGQRQRVGVARALAADPPVLLMDEPFGAVDPVVREHLQNEFLRLQQAVRKTVLFVTHDIEEAVRLGDRIAVYGQGRIEQFDTPSTVLGAPANEYVADFVGADRGLKRLSVTPMEESDLEQPPVVHLDDPLPAKLDAPWAVVLDGDNNLHGWISAEHARVQSGTVREHARRMEAWLPVGASLKQAFATMLQHDAGWIAVIDEHSEGRFLGVLTPARLHEALRRSTAADARDIPRAEVELETVAGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JJX2</accession>
    <name>A0A2M9JJX2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_34820</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000022">
        <property type="protein sequence ID" value="PJN07171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN07171">
        <property type="protein sequence ID" value="PJN07171"/>
        <property type="gene ID" value="CG723_34820"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046291">
        <property type="entry name" value="DUF6328"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19853">
        <property type="entry name" value="DUF6328"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="24"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="56"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="98"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="124"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN07171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="165" mass="17360" checksum="6B3149776CEDB0FE" modified="2018-04-25" version="1">MGRDRHETPLERADRNFGELLQELRVTQTGVQILFAFLLTLAFTPRFPALDGVQRATYIATLLLAVLAAALFTAPAALHRALFGRGAKPEIVQMSSRLAAAGLGVLMLALAGSVLLVVDVTTGRAAGIAAGAGTFAVCAGLWGVLPRLVRRSLTRAQEKTGTPSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JK64</accession>
    <name>A0A2M9JK64_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Adenosylmethionine-8-amino-7-oxononanoate aminotransferase</fullName>
            <ecNumber evidence="4">2.6.1.62</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">7,8-diamino-pelargonic acid aminotransferase</fullName>
            <shortName evidence="4">DAPA AT</shortName>
            <shortName evidence="4">DAPA aminotransferase</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">7,8-diaminononanoate synthase</fullName>
            <shortName evidence="4">DANS</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">Diaminopelargonic acid synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">bioA</name>
        <name evidence="6" type="ORF">CG723_34850</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CB01635</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Catalyzes the transfer of the alpha-amino group from S-adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only aminotransferase known to utilize SAM as an amino donor.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>(8S)-8-amino-7-oxononanoate + S-adenosyl-L-methionine = (7R,8S)-7,8-diammoniononanoate + S-adenosyl-4-methylsulfanyl-2-oxobutanoate</text>
            <dbReference type="Rhea" id="RHEA:16861"/>
            <dbReference type="ChEBI" id="CHEBI:16490"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:149468"/>
            <dbReference type="ChEBI" id="CHEBI:149469"/>
            <dbReference type="EC" id="2.6.1.62"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 4">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">Cofactor biosynthesis; biotin biosynthesis; 7,8-diaminononanoate from 8-amino-7-oxononanoate (SAM route): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. BioA subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.62" evidence="4"/>
    <dbReference type="EMBL" id="NNBL01000022">
        <property type="protein sequence ID" value="PJN07177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN07177">
        <property type="protein sequence ID" value="PJN07177"/>
        <property type="gene ID" value="CG723_34850"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00078">
        <property type="reaction ID" value="UER00160"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004015">
        <property type="term" value="F:adenosylmethionine-8-amino-7-oxononanoate transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009102">
        <property type="term" value="P:biotin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00610">
        <property type="entry name" value="OAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00834">
        <property type="entry name" value="BioA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005814">
        <property type="entry name" value="Aminotrans_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005815">
        <property type="entry name" value="BioA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00202">
        <property type="entry name" value="Aminotran_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00508">
        <property type="entry name" value="bioA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00600">
        <property type="entry name" value="AA_TRANSFER_CLASS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="4" id="KW-0093">Biotin biosynthesis</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 4 5" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Pyridoxal phosphate binding" evidence="4">
        <location>
            <begin position="131"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Pyridoxal phosphate binding" evidence="4">
        <location>
            <begin position="324"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="71"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="164"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="261"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="290"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="323"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="407"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Participates in the substrate recognition with KAPA and in a stacking interaction with the adenine ring of SAM" evidence="4">
        <location>
            <position position="29"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="4">
        <location>
            <position position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PJN07177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="440" mass="47151" checksum="D3819387D25A863A" modified="2018-04-25" version="1">MPEVSGLPVSGLPVAELLDLDRRHVWHPYGPMPGRQEPLVVESAAGVRLRLAGRGGGVGEGAELVDGMSSWWSAVHGYNHPVLNEAVRDQLGRMSHVMFGGLTHEPAVGLAKRLVDMSPEGLEHVFLADSGSVSVEVAIKMCLQHWRSLGKPEKRRLLTWRGGYHGDTWQPMAVCDPEGGMHELWSGALPQHVFADAPPAAYEEAYADHLHELIARHAHELAAVIVEPVVQGAGGMRFHSPAYLRVLREACDAHDVLLVFDEIATGFGRTGTLFAAEHASVTPDVMCVGKALTGGYMTMAATLCTARVADGISRGEVPVLAHGPTFMGNPLAAAVACASIDLLLGQDWATEVKRIESGLRESLAAASELPGVRDVRVLGAIGVVQLDHEIDMAAATRAAVREGVWLRPFRDLVYTMPPYITGDEDLARIGRAVCAAAREG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JKH4</accession>
    <name>A0A2M9JKH4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">GntR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CG723_34535</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000021">
        <property type="protein sequence ID" value="PJN07370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN07370">
        <property type="protein sequence ID" value="PJN07370"/>
        <property type="gene ID" value="CG723_34535"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07377">
        <property type="entry name" value="WHTH_GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.530">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011711">
        <property type="entry name" value="GntR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008920">
        <property type="entry name" value="TF_FadR/GntR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07729">
        <property type="entry name" value="FCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
        <property type="entry name" value="GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00895">
        <property type="entry name" value="FCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00345">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48008">
        <property type="entry name" value="SSF48008"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50949">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH gntR-type" evidence="4">
        <location>
            <begin position="17"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PJN07370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="234" mass="26070" checksum="DDBB5F4C05B5D99A" modified="2018-04-25" version="1">MAELNGLADDRALLGRTSTAERVADILRSRIAEGYFPPGTRLSEDSIGGALGISRNTLREAFRLLTHERLLVHQLNRGVFVRVLTVEDVEDIYLTRRLVECAVVRGLGRPPYDLGAVADAVADGHRAAKAREWKGVSTANIHFHRELVALAGSARTDELMRSVFAELRLAFHVVDDPRRLHEPYLARNKEILGTLEAGRPDDAERLLDQYLDDSREGLVDVYGRRVAQGERPDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JKN1</accession>
    <name>A0A2M9JKN1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GNAT family N-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_33555</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000020">
        <property type="protein sequence ID" value="PJN07430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN07430">
        <property type="protein sequence ID" value="PJN07430"/>
        <property type="gene ID" value="CG723_33555"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013653">
        <property type="entry name" value="FR47"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08445">
        <property type="entry name" value="FR47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="104"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN07430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="239" mass="25402" checksum="DAA9F41FD53C5509" modified="2018-04-25" version="1">MSVPAAATAHPLDNPAHASLTGPHAHFAEWRGRIVRYPLDVTPWLALPDEPGPGDWADLAALAGPGETVPLLGMRAAPPEGWELTMSMDGVQLVDDGVAVAPDAEAVLLGAADVPEMLDLVARTRPGPFLPRTVELGTYLGIRRQGALVAMAGERLHPPGWTEISAVCTDPDHRGQGLAARLVLAVAAGIKDRGETPFLHTAAGNTNAIRLYESLGFRLRRTTKFMTARVPEFDHAAAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JLU9</accession>
    <name>A0A2M9JLU9_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Methyltransf_25 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_30975</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000017">
        <property type="protein sequence ID" value="PJN07832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN07832">
        <property type="protein sequence ID" value="PJN07832"/>
        <property type="gene ID" value="CG723_30975"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041698">
        <property type="entry name" value="Methyltransf_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13649">
        <property type="entry name" value="Methyltransf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Methyltransf_25" evidence="1">
        <location>
            <begin position="46"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN07832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="269" mass="30232" checksum="00F6ACEB77DE553C" modified="2018-04-25" version="1">MRPNRHDLGGVFNEVPELYDRVRPGYPDELFADLGSITGMDERSSVLEVGCGTGQATRSLAALGCSVTAIEPGADMAALARQRITSFRNVEVETSMFEEWDDRGRRFDVLVAASSWHWVDPSIGWQRAHDVLYPAGWMALLGNVVVRRPGESEVYAETADLHERFCPGNPGWGHPPLEDDVRTTDEGWGLVDDPGGLFGSTIVRWYPTVQWFNGDGFADHLRSLSLYRRLDRDVREPLLDAIAERIRTRMGDRASRRYLSVLRVGQRAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JLZ0</accession>
    <name>A0A2M9JLZ0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CG723_31280</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000017">
        <property type="protein sequence ID" value="PJN07878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN07878">
        <property type="protein sequence ID" value="PJN07878"/>
        <property type="gene ID" value="CG723_31280"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.490.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018727">
        <property type="entry name" value="DUF2267"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038282">
        <property type="entry name" value="DUF2267_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10025">
        <property type="entry name" value="DUF2267"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PJN07878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="128" mass="14000" checksum="20178BC5CFBDB96C" modified="2018-04-25" version="1">MRWDAFLEQVQERGQYATPQEAERSARTVLALLGAHLVGEVRAELAARLPETFAVILLNPLQATEPLSPERFVRATAAWIEGATERTAAWDVSAVLSVAADAAGEDLTHRILLQLPPGYDLLFGHPET</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JML5</accession>
    <name>A0A2M9JML5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alpha/beta hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_30665</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000016">
        <property type="protein sequence ID" value="PJN08047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08047">
        <property type="protein sequence ID" value="PJN08047"/>
        <property type="gene ID" value="CG723_30665"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00111">
        <property type="entry name" value="ABHYDROLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="23"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN08047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="294" mass="31742" checksum="62F1FF436A84378E" modified="2018-04-25" version="1">MPLVEVSPGMSLAYETFGDPSDPPVLLVMGFGAQMIAWHEDFCRALANRGRYVIRYDNRDCGLSTRFGEHPVDMGRFIAAVSSGDIASALSMVPYALTDMAADGLNLLTALGIERAHVIGTSMGGMIAQKMAITEPSRVLTLTSMMSSTGEPEYGQSVPEAQAVLLSPKPADREGYIAAADRELLWASRRYGDAALLRELAARSYDRAYYPAGVGRQLGAMILDGSRAEALRTLRVPTLVIHGLDDTLIVPSGGERTAELVPGAKLLLIPDMGHDRPRELWPEIIGAVQTHTEM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JMU1</accession>
    <name>A0A2M9JMU1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Amino acid permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CG723_29410</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CB01635</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000015">
        <property type="protein sequence ID" value="PJN08127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08127">
        <property type="protein sequence ID" value="PJN08127"/>
        <property type="gene ID" value="CG723_29410"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004841">
        <property type="entry name" value="AA-permease/SLC12A_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00324">
        <property type="entry name" value="AA_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="31"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="57"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="139"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="164"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="207"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="247"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="309"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="349"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="379"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="410"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="435"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="domain" description="AA_permease" evidence="7">
        <location>
            <begin position="50"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PJN08127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="462" mass="47717" checksum="3C56E4341B405822" modified="2018-04-25" version="1">MSAHTAPPAGEEGQPPAGEDTLRRSLGFRDLVVYGLLFIAPMAPVGVFGTLDAKSHGAVALVYVVATVAMAFTAFSYAQMVRVAPQAGSVFTYARVGLGEAPGFIAGWMAMLDYLLIPAVAYLFSGIAMNALVPSVSRWVWTALAVVITTLLNLWGVRAAARAGFAVLAMEIVVLLVFLGSAIVVLVRDGAERGWLSPLTGDGSQGAFALSAVVGAVSVAVLSYLGFDAIVSFAEEVTGGSAKVARAVLFCLALAGVLFIAQTYLVALLEPVSSAELAADPAKQGSAFYDAIDVSVGGWLHDLVAVSKAIGAAFAALAGQAAAGRLLFAMARDRQLPKALSRTDSGVPRVALLCAAVVTLVAAVWAARRDDGLDHLVSVVDIGALTAFVLLHASVVGWFVVRRGAGTFSWWRHLIVPVLGAAVTVAVIVEASGTAQVVGAIWLAVGLVVLVAQRGRRGARVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JMW1</accession>
    <name>A0A2M9JMW1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DivIVA domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_29770</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000015">
        <property type="protein sequence ID" value="PJN08194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08194">
        <property type="protein sequence ID" value="PJN08194"/>
        <property type="gene ID" value="CG723_29770"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019933">
        <property type="entry name" value="DivIVA_domain"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03544">
        <property type="entry name" value="DivI1A_domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014902917" evidence="2">
        <location>
            <begin position="31"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="26"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN08194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="119" mass="12601" checksum="6214659D18A4C1FA" modified="2018-04-25" version="1">MVMFLFLVVALVVVVGAVTLAVLGGGESGALPEAPPEQFTDPLPHDRPVGRADVEALRLPVALRGYRMAEVDDALGRLGAELAERDQRISDLEIALSGARAQMRPQGPGFGRHPGEGHQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JN21</accession>
    <name>A0A2M9JN21_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Inhibition of morphological differentiation protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_28105</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HAD-like hydrolase superfamily. SerB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000014">
        <property type="protein sequence ID" value="PJN08272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08272">
        <property type="protein sequence ID" value="PJN08272"/>
        <property type="gene ID" value="CG723_28105"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006385">
        <property type="entry name" value="HAD_hydro_SerB1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01490">
        <property type="entry name" value="HAD-SF-IB-hyp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="253"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN08272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="281" mass="30822" checksum="B31C9CBBA5167178" modified="2018-04-25" version="1">MLELVENHSLTHSMPRTAAFFDLDKTVIAKSSTLTFSKSFYQGGLINRRAVLRTAYAQFVFLAGGADHDQMERMRSYLSALCRGWNVQQVKEIVAETLHDLIDPIIYDEAASLIEEHHTAGRDVVIVSTSGAEVVEPIGELLGADRVVATRMVVGDDGCFTGEVEYYAYGPTKAEAIEELARSEGYDLSRCYAYSDSATDVPMLKSVGHPFAVNPDRALRREAIAREWPILDFNRPVRLKQRLPSLSAPSRPALVVAAAVGAAAATAGLVWYASRRRATVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JND2</accession>
    <name>A0A2M9JND2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Aminotransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_28720</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000014">
        <property type="protein sequence ID" value="PJN08370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08370">
        <property type="protein sequence ID" value="PJN08370"/>
        <property type="gene ID" value="CG723_28720"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044249">
        <property type="term" value="P:cellular biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotran_1_2" evidence="1">
        <location>
            <begin position="37"/>
            <end position="391"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN08370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="395" mass="42420" checksum="5CF9A5E4691C6A42" modified="2018-04-25" version="1">MAAMTSSARPLLNRRLAEFGTTIFAEMSALATATGSINLGQGFPDTDGPEEIREAAVRALRDGRGNQYPPGPGVPELRTAIAAHQEHRYGLTFDPDREVLVTAGATEAIAASLLALVEPGDEVVALEPYYDSYAASIALAGGTRVPVTLRPDGGAFRLDLDELRAAVTDRTRLLLINTPHNPTGTVLTREELTAIAALAVERDLLVITDEVYEHLTFGDAGHIPLATLPGMRERTVTIGSAGKTFSFTGWKVGWVTASPELVTAVRSAKQFLTYVASGPFQYAIAEALSLPDSYYDAFRADMSAKRDLLADGLAAAGFEVFRPAGTYFVTTDIRPLGESDGFAFCRALPERAGVVAIPNAVFYDHRDAGAPFVRFAFCKRIPVLEEAVDRLKKLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JNI2</accession>
    <name>A0A2M9JNI2_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Chaperone protein ClpB</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11 13" type="primary">clpB</name>
        <name evidence="13" type="ORF">CG723_28760</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">CB01635</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homohexamer. The oligomerization is ATP-dependent.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Homohexamer; The oligomerization is ATP-dependent.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the ClpA/ClpB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000014">
        <property type="protein sequence ID" value="PJN08377.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08377">
        <property type="protein sequence ID" value="PJN08377"/>
        <property type="gene ID" value="CG723_28760"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042026">
        <property type="term" value="P:protein refolding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009408">
        <property type="term" value="P:response to heat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1780.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017730">
        <property type="entry name" value="Chaperonin_ClpB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019489">
        <property type="entry name" value="Clp_ATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036628">
        <property type="entry name" value="Clp_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004176">
        <property type="entry name" value="Clp_R_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001270">
        <property type="entry name" value="ClpA/B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018368">
        <property type="entry name" value="ClpA/B_CS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028299">
        <property type="entry name" value="ClpA/B_CS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041546">
        <property type="entry name" value="ClpA/ClpB_AAA_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07724">
        <property type="entry name" value="AAA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17871">
        <property type="entry name" value="AAA_lid_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02861">
        <property type="entry name" value="Clp_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10431">
        <property type="entry name" value="ClpB_D2-small"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00300">
        <property type="entry name" value="CLPPROTEASEA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01086">
        <property type="entry name" value="ClpB_D2-small"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81923">
        <property type="entry name" value="SSF81923"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03346">
        <property type="entry name" value="chaperone_ClpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51903">
        <property type="entry name" value="CLP_R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00870">
        <property type="entry name" value="CLPAB_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00871">
        <property type="entry name" value="CLPAB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 10" id="KW-0143">Chaperone</keyword>
    <keyword evidence="6 11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 9" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 11" id="KW-0346">Stress response</keyword>
    <feature type="domain" description="Clp R" evidence="12">
        <location>
            <begin position="1"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="414"/>
            <end position="494"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00026057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU362034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PJN08377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="871" mass="94535" checksum="213B634E93E16A7B" modified="2018-04-25" version="1">MDAELTNRSRDAINAATSRAVSGGHADLTPAHLLLALLEGQENENITDLLTAVDADQAAVRSGAERVLGALPSVTGSTVAPPGPNRDLLAVIADAAQRAEGLGDEYLSTEHLLIGIAAKGGTVADVLTEQGASAEKLLAAFEKSRGGRRVTTPDPEGQYKALEKFGTDFTAAAREGRLDPVIGRDQEIRRVVQVLSRRTKNNPVLIGEPGVGKTAVVEGLAQRIVKGDVPESLKNKRLVSLDLGAMVAGAKYRGEFEERLKTVLSEIKESDGQVITFIDELHTVVGAGAGGDSSMDAGNMLKPMLARGELRMVGATTLDEYRERIEKDPALERRFQQVLVAEPTVEDSIAILRGLKGRYEAHHKVQIADSALVAAASLSDRYITSRFLPDKAIDLVDEAASRLRMEIDSSPVEIDELQRAVDRLKMEELALSKETDPASKQRLEKLRRDLADKEEELRGLTARWEKEKQSLNRVGELKEKLDELRGQAERAQRDGDFDTASKLLYGEIPTLERDLAAATEEEVEASKADTMVKEEVGPDDIADVVAAWTGIPAGRLLEGETQKLLRMEDELGKRLIGQSEAVGAVSDAVRRTRAGIADPDRPTGSFLFLGPTGVGKTELAKALADFLFDDERAMIRIDMSEYGEKHSVARLVGAPPGYVGYEEGGQLTEAVRRRPYSVVLLDEVEKAHPEVFDVLLQVLDDGRLTDGQGRTVDFRNTILVLTSNLGSQFLSGHSLVEPTTSEEQKKQQVLDVVRASFKPEFLNRLDDLVVFSALDKEELERIAKLQIGRLAKRLAERRLTLDVSDAALAWLAEEGNDPAYGARPLRRLVQTAIGDRLAKEILSGEVTDGDTVCVDAFGGGLIVGPATGKTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JNQ1</accession>
    <name>A0A2M9JNQ1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MBL fold metallo-hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_28950</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000014">
        <property type="protein sequence ID" value="PJN08499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08499">
        <property type="protein sequence ID" value="PJN08499"/>
        <property type="gene ID" value="CG723_28950"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lactamase_B" evidence="1">
        <location>
            <begin position="41"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN08499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="264" mass="28274" checksum="AF70B77778993982" modified="2018-04-25" version="1">MQVGELKVSYVPDGAMLFKPPGPPRAGGGGAYLNDTARLVANTGGLLVQFDGRALLIDAGFGPHSVPEDPEHPYIGAVHGGSLLDNLARLGVRPDEIEVVAFTHLHRDHIGWACTDPPVFTAATFAVPKSEWENRHQATGPTTGTPATLERRLRLVVPGEEIFPGVRALALPGHTAGHTGFTITSRGRRLLAFGDALHSPLQVRHPEWFTVSEGDPAQSERHRRRLISELQQPGTLGFGIHFADVVFGQVVPDGAGEGADWLPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-05-25" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JNT4</accession>
    <name>A0A2M9JNT4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CG723_27500</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000013">
        <property type="protein sequence ID" value="PJN08528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08528">
        <property type="protein sequence ID" value="PJN08528"/>
        <property type="gene ID" value="CG723_27500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046102">
        <property type="entry name" value="DUF6039"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19505">
        <property type="entry name" value="DUF6039"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PJN08528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="274" mass="30661" checksum="AB4539F87BEC30B0" modified="2018-04-25" version="1">MTTLTFHSTNSGVIVERTAQLKQAHRAEGRRIALEQAAYLNDKFAGQTTVTVHEETFGVRDRLHWLVHLPKLSGHREISRLLDGDEGPAADADWHGMFVDGSFSETALIPQHWGMYGTDEALPEGTVIDAAAPDLRVPPAQRQTSMSPERTLNSSGAGLMIHRVAQPKYAFRAEARLFARRITESINTRLPGIASSFLYEEAFGPADRVHWLIHMKSEDTYYDLIDMHMRMDDATRAIYLDEIIAPEKGGGTWNRLFVEESMGDIAFSPVPDAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JNU9</accession>
    <name>A0A2M9JNU9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Biosynthesis cluster domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_27485</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000013">
        <property type="protein sequence ID" value="PJN08525.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08525">
        <property type="protein sequence ID" value="PJN08525"/>
        <property type="gene ID" value="CG723_27485"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040718">
        <property type="entry name" value="LnmK_N_HDF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18238">
        <property type="entry name" value="LnmK_N_HDF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="SSF54637"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LnmK_N_HDF" evidence="1">
        <location>
            <begin position="16"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF18238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN08525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="319" mass="35438" checksum="0A5FBF7990CC7467" modified="2018-04-25" version="1">MTITSSLDVRPEIKQAVTVRPGMCGPGSLFVGQLGDWTWETVSAQCDTDVFAARDASGNPTYLAFYYFRVRGGRELHPGSLTFGDRLTVTSGCYDQGTESVLTLHRIDRAADEDAQRPLDLHEFYERPRDGSLYVENFNRWVTRSAPGSNEDLVKSSPPGFRNDGLPQLPAAYSPRAVYREARTAHTFRALDEPGFRLLPDTVEVEHPVDIVRDVNGVGLLYFASYFSMVDKAALALWRRLGRSDRAFLRRVVVDQQMCYLGNADLDSVLTLGARVRVSTETPGEELVDVVISDRDSGRVIAVSTLHTQHDAHDPKGEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JNY4</accession>
    <name>A0A2M9JNY4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">S-adenosylhomocysteine deaminase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_27800</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000013">
        <property type="protein sequence ID" value="PJN08574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08574">
        <property type="protein sequence ID" value="PJN08574"/>
        <property type="gene ID" value="CG723_27800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01979">
        <property type="entry name" value="Amidohydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="SSF51338"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydro-rel" evidence="1">
        <location>
            <begin position="67"/>
            <end position="416"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN08574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="471" mass="49790" checksum="2543C24D0FBAA2EA" modified="2018-04-25" version="1">MNRSDRDFLAGPGPLLLVPDAVLLPEGPADGWAVTIDDGRFEAVGPADELEGAHPQLPAVRLPGHLLMPGFVDAHHHLTQSFGSALAFGEPSEIFRRVWVPLEGALDEESAYTAAKLAALEALRGGFTTVTDAGTRAGVDVDVVASAARDAGIRCVLGLVCNDADEDATDPPAVVEHAEKHLARYDGDPLVHPSLAVSIPEAATERTLHATARLAAEAGAVVQIHVNEHLAGVERSLVRHGLRPLEHLHRVGALGPQLLAAHATMLTPRELTLLADTGTAVSYNPVASAWKGNAVAPATAMAERGIRFGLGTDGTRGDGFRLAEAAEFAQRLAYGLATGDSSCGAGWTWLERANRGGADAVGLGARTGTVAQGMAADFLLVDVDTPELALSWDLPWELVRRGNRDQIAAVFVAGRLRMWHGRPVGWDGPELVRRAVELARAAVARANVTRAHPTSTAARALIWSQERRTTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JP45</accession>
    <name>A0A2M9JP45_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Dihydrofolate reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CG723_26410</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CB01635</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DtxR/MntR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000012">
        <property type="protein sequence ID" value="PJN08636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08636">
        <property type="protein sequence ID" value="PJN08636"/>
        <property type="gene ID" value="CG723_26410"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046914">
        <property type="term" value="F:transition metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.60.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040767">
        <property type="entry name" value="DtxR_SH3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007167">
        <property type="entry name" value="Fe-transptr_FeoA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001367">
        <property type="entry name" value="Fe_dep_repressor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036421">
        <property type="entry name" value="Fe_dep_repressor_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038157">
        <property type="entry name" value="FeoA_core_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022687">
        <property type="entry name" value="HTH_DTXR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022689">
        <property type="entry name" value="Iron_dep_repressor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008988">
        <property type="entry name" value="Transcriptional_repressor_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18357">
        <property type="entry name" value="DtxR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02742">
        <property type="entry name" value="Fe_dep_repr_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01325">
        <property type="entry name" value="Fe_dep_repress"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00899">
        <property type="entry name" value="FeoA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00529">
        <property type="entry name" value="HTH_DTXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47979">
        <property type="entry name" value="SSF47979"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50037">
        <property type="entry name" value="SSF50037"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50944">
        <property type="entry name" value="HTH_DTXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH dtxR-type" evidence="8">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50944"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PJN08636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="230" mass="25171" checksum="042E48F9356D79AB" modified="2018-04-25" version="1">MSGLIDTTEMYLRTILELEEEGVVPMRARIAERLDQSGPTVSQTVARMERDGLVAVATDRHLELTDEGRRLATRVMRKHRLAECLLVDVIGLEWEQVHAEACRWEHVMSEAVERRVLELLRHPTESPYGNPIPGLEELGEKDGADPFLDEGMVSLADLDPGTDGKTVVVRRIGEPIQTDAQLMYTLRRAGIQPGSVVSVTASPGGVLVGSSGEAAELVADVASHVFVAKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JPD3</accession>
    <name>A0A2M9JPD3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CG723_26980</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CB01635</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000012">
        <property type="protein sequence ID" value="PJN08731.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08731">
        <property type="protein sequence ID" value="PJN08731"/>
        <property type="gene ID" value="CG723_26980"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd16913">
        <property type="entry name" value="YkuD_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.440.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041280">
        <property type="entry name" value="Big_10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005490">
        <property type="entry name" value="LD_TPept_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038063">
        <property type="entry name" value="Transpep_catalytic_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17964">
        <property type="entry name" value="Big_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03734">
        <property type="entry name" value="YkuD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141523">
        <property type="entry name" value="SSF141523"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="31"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="domain" description="Big_10" evidence="7">
        <location>
            <begin position="90"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="domain" description="YkuD" evidence="6">
        <location>
            <begin position="267"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="49"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="102"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF03734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF17964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PJN08731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="427" mass="44784" checksum="564CC07BDE51E048" modified="2018-04-25" version="1">MEHLVTTPDRAAHQQHPRQPERGRRRTARRFLVATAALAVGALALTACGGNADGENTDGKNGDSKGKGSSAAQITISAKDGSTGASINATGVKVKSGKLTDVTMTEPDSGKTVPGSLTANGSVWKPKEQLERGTKYRISATAKDSEGRPAAANSIFTTVTTSGSFIGTYTPDGGTTVGVGMPVSFTFDKAITDKKAVQSHITVSSSSGQQIVGHWFGAQRLDFRPQEYWKAGSKVTMKIDLDGVEGANGVTGVQNKTVSFTVGRSQVSTVDVNTQTMTVVRDGETIKSIPISAGSAQHTTYNGQMVISEKFVQTRMNGSTVGFGGEYDIPDVPHAMRLSSSGTFIHGNYWYPKGNPPFGRSGTSHGCIGLADVQGAGGATIAKWFYDNSLVGDVVTVKHSPDTTIAPDNGLNGWNMSWSQWTAGSAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JPH9</accession>
    <name>A0A2M9JPH9_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 8">UDP-glucose 4-epimerase</fullName>
            <ecNumber evidence="5 8">5.1.3.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">galE</name>
        <name evidence="10" type="ORF">CG723_27260</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CB01635</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>UDP-alpha-D-glucose = UDP-alpha-D-galactose</text>
            <dbReference type="Rhea" id="RHEA:22168"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="ChEBI" id="CHEBI:66914"/>
            <dbReference type="EC" id="5.1.3.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 8">
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 8">Carbohydrate metabolism; galactose metabolism.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 8">Belongs to the NAD(P)-dependent epimerase/dehydratase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.1.3.2" evidence="5 8"/>
    <dbReference type="EMBL" id="NNBL01000012">
        <property type="protein sequence ID" value="PJN08779.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08779">
        <property type="protein sequence ID" value="PJN08779"/>
        <property type="gene ID" value="CG723_27260"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00214"/>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003978">
        <property type="term" value="F:UDP-glucose 4-epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006012">
        <property type="term" value="P:galactose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd05247">
        <property type="entry name" value="UDP_G4E_1_SDR_e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005886">
        <property type="entry name" value="UDP_G4E"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01179">
        <property type="entry name" value="galE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="8" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7 8" id="KW-0520">NAD</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Epimerase" evidence="9">
        <location>
            <begin position="6"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00018569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU366046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PJN08779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="321" mass="33756" checksum="60F88CA4DF9E037B" modified="2018-04-25" version="1">MSGKYLVTGGAGYVGSVVAQHLVEAGHDVTVLDNLSTGFREGVPAGVTFIEGDIRDAAKWLDPSFDAVLHFAAFSQVGESVVKPEKYWDNNVGGTMALLAAMRSADVRKLVFSSTAATYGEPVSTPITESDPTAPTSPYGASKLAVDHMITGEAAAHGLAAVSLRYFNVAGAYGSCGERHDPESHLIPLVLQVAQGRRDAISVFGDDYPTPDGTCVRDYIHVADLAEAHLLALDAARPAEHLICNLGNGNGFSVREVIETVRQVTGHPIPEVTAPRRGGDPAVLVASAATARERLGWNPSRADLAGIVADAWAFAQARQEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JPM2</accession>
    <name>A0A2M9JPM2_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Trans-aconitate 2-methyltransferase</fullName>
            <ecNumber evidence="1">2.1.1.144</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">tam</name>
        <name evidence="3" type="ORF">CG723_27285</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the S-adenosylmethionine monomethyl esterification of trans-aconitate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-adenosyl-L-methionine + trans-aconitate = (E)-3-(methoxycarbonyl)pent-2-enedioate + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:14969"/>
            <dbReference type="ChEBI" id="CHEBI:15708"/>
            <dbReference type="ChEBI" id="CHEBI:57470"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="EC" id="2.1.1.144"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the methyltransferase superfamily. Tam family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.144" evidence="1"/>
    <dbReference type="EMBL" id="NNBL01000012">
        <property type="protein sequence ID" value="PJN08822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08822">
        <property type="protein sequence ID" value="PJN08822"/>
        <property type="gene ID" value="CG723_27285"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030798">
        <property type="term" value="F:trans-aconitate 2-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.290">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00560">
        <property type="entry name" value="Tran_acon_Me_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041698">
        <property type="entry name" value="Methyltransf_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023506">
        <property type="entry name" value="Trans-aconitate_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023149">
        <property type="entry name" value="Trans_acon_MeTrfase_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13649">
        <property type="entry name" value="Methyltransf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="1 3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransf_25" evidence="2">
        <location>
            <begin position="36"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN08822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="263" mass="29074" checksum="BDBFEA0B65A64A2C" modified="2018-04-25" version="1">MSAPTWDPQQYLRHADHRTRPFADLLARVKGDPARIADLGCGAGNVTALLAQRWPKARITGYDNSPQMLEKAAAHATDLLDFAPADAATWTPAEPFDLIVSNALLQWVPGHTDRFPDWLAGIAPGGTFAFQVPGNFDAPSHVLMRELARSARWRDRLGDTLRHADAVHTPEQYLNKLTALGCDADVWETTYLHLLQGEDPVLDWVKGTGLRPVLTALADDPQATDEFLTDYRAQLRTAYPATPQGTVFPFRRLFAVARKPADT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JPX5</accession>
    <name>A0A2M9JPX5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Spermidine synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CG723_25970</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000011">
        <property type="protein sequence ID" value="PJN08933.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08933">
        <property type="protein sequence ID" value="PJN08933"/>
        <property type="gene ID" value="CG723_25970"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PJN08933.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="233" mass="25238" checksum="D6B8BFE1152E27B3" modified="2018-04-25" version="1">MSTSYPTPYDTDHTAPVVLDRREGPFGEVVLRRHGALLQIIANGCFLMDTSDGRSERLLVDAALDALDDRPAPRILIGGLGVGFSLTHAAANSRWGRIAVVEREPAIVDWHREGPLSELSRSALADPRTEIVEADLVSYVQESTETYDALCLDIDNGPDWTVTEGNDNLYSPVGLAACRERLAPGGVLAVWSAQPSANFEGTLWNAGFRSVRTEEIPVVRGVPDVVHLGVRPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JQF3</accession>
    <name>A0A2M9JQF3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Glycoside hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CG723_24575</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CB01635</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C40 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000010">
        <property type="protein sequence ID" value="PJN09098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN09098">
        <property type="protein sequence ID" value="PJN09098"/>
        <property type="gene ID" value="CG723_24575"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000064">
        <property type="entry name" value="NLP_P60_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00877">
        <property type="entry name" value="NLPC_P60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="SSF54001"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51935">
        <property type="entry name" value="NLPC_P60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015006591" evidence="3">
        <location>
            <begin position="30"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="domain" description="NlpC/P60" evidence="4">
        <location>
            <begin position="237"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="179"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PJN09098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="353" mass="38235" checksum="32EFE6B69CCDF02E" modified="2018-04-25" version="1">MSKRTTTVMAAVALVSALTVLTAPGAAYASPARPAPPSTAGRGPDLEAVRAKLDGLYHDAAVATEAYNAAEEKARKQSGQIVQLAKDIVAGQKKLDRLKSRAGAAARQQYRNGGMPPEAQLMLSDNPSRFLDGADRMRQGQHATKGLMGELTRTQEDLQTYAQDATRNWKKLEANRREKARAQKKIKSRIAEAEKLESQLEKKERERLKELEQQAEYKQQTAWLSSGVLKDIKGSASARGKKAVAFATGQLGKPYVWGAEGPGSYDCSGLTSQAWSAAGRPIPRTSQEQWKQLKHIDIKDMRPGDLIIYHDDASHVGMYIGDGAIVHAPRPGRNVTVAGAGSMTILGVVRPDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JQG6</accession>
    <name>A0A2M9JQG6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Flavin oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_24635</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000010">
        <property type="protein sequence ID" value="PJN09106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN09106">
        <property type="protein sequence ID" value="PJN09106"/>
        <property type="gene ID" value="CG723_24635"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016646">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002563">
        <property type="entry name" value="Flavin_Rdtase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01613">
        <property type="entry name" value="Flavin_Reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00903">
        <property type="entry name" value="Flavin_Reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flavin_Reduct" evidence="1">
        <location>
            <begin position="19"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN09106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="178" mass="17963" checksum="EB8B288C2AE0C62B" modified="2018-04-25" version="1">MTTAPDQLLTSRQDFVAAMGNAATGVTVVSTEGPAGRFAQTVSAMCSVSADPPSLLVCVNERSPLAAAAVRNGVIAVSVLAAGQAHVSDVFAGRPARGSGPYDFDSAEWDVLATGAPVLRGAAAAFDCRLADSVTQGTHQVLFGAVVASAVSGAHPLVHHARTYATPSPLNSLKEHGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JQI5</accession>
    <name>A0A2M9JQI5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DNA methylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CG723_24780</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000010">
        <property type="protein sequence ID" value="PJN09132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN09132">
        <property type="protein sequence ID" value="PJN09132"/>
        <property type="gene ID" value="CG723_24780"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PJN09132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="246" mass="27319" checksum="0E81AA84E9899AC2" modified="2018-04-25" version="1">MTQPTDIRREHSRLEPFRVLDAFSCIGGATNGYRRAFGPNCHITGVDIQAQPDYCGDAFHQGDAIDYIRAHGHEFDFIHVSPPCQGEGAPTKGTNAARNAAIGRTYPRLIVPTRAALEATGRPYVMENVAGSDVRKDIRLCGEQFCLAVLMHRYFELGGWTFPQPVHPRHRGYVRGYRHGVWRDGPYVAAYGKGGGKATVEEIRKAKGIDWSTDHLRLREALPPAYTEWIGAAYLTTLAPRLEDAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JQM6</accession>
    <name>A0A2M9JQM6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_24990</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000010">
        <property type="protein sequence ID" value="PJN09169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN09169">
        <property type="protein sequence ID" value="PJN09169"/>
        <property type="gene ID" value="CG723_24990"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="25"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN09169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="94" mass="10151" checksum="79C09D6FD6D716F7" modified="2018-04-25" version="1">MAESTFSKISWTEFRPDQGRLTTGAVLTGAGMLIGAAGVGLLVFELVRAGRTWTSSWEVPPGEMASRTLHQAQSAVQAGREAWTSYQESPVPHF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JQQ5</accession>
    <name>A0A2M9JQQ5_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Futalosine hydrolase</fullName>
            <shortName evidence="1">FL hydrolase</shortName>
            <ecNumber evidence="1">3.2.2.26</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Futalosine nucleosidase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Menaquinone biosynthetic enzyme MqnB</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">mqnB</name>
        <name evidence="3" type="ORF">CG723_25155</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the hydrolysis of futalosine (FL) to dehypoxanthine futalosine (DHFL) and hypoxanthine, a step in the biosynthesis of menaquinone (MK, vitamin K2).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>futalosine + H2O = dehypoxanthine futalosine + hypoxanthine</text>
            <dbReference type="Rhea" id="RHEA:25904"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17368"/>
            <dbReference type="ChEBI" id="CHEBI:58863"/>
            <dbReference type="ChEBI" id="CHEBI:58864"/>
            <dbReference type="EC" id="3.2.2.26"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Quinol/quinone metabolism; menaquinone biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the PNP/UDP phosphorylase family. Futalosine hydrolase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.2.26" evidence="1"/>
    <dbReference type="EMBL" id="NNBL01000010">
        <property type="protein sequence ID" value="PJN09200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN09200">
        <property type="protein sequence ID" value="PJN09200"/>
        <property type="gene ID" value="CG723_25155"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00079"/>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016799">
        <property type="term" value="F:hydrolase activity, hydrolyzing N-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009234">
        <property type="term" value="P:menaquinone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009116">
        <property type="term" value="P:nucleoside metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1580">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00991">
        <property type="entry name" value="MqnB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019963">
        <property type="entry name" value="FL_hydrolase_MqnB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000845">
        <property type="entry name" value="Nucleoside_phosphorylase_d"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035994">
        <property type="entry name" value="Nucleoside_phosphorylase_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01048">
        <property type="entry name" value="PNP_UDP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53167">
        <property type="entry name" value="SSF53167"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03664">
        <property type="entry name" value="fut_nucase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0474">Menaquinone biosynthesis</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PNP_UDP_1" evidence="2">
        <location>
            <begin position="45"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN09200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="235" mass="23203" checksum="FD7E654F01064BDB" modified="2018-04-25" version="1">MVLQAQEGRLTDSGRVLIATAVPAERDAVVRGLSEAGAAHPAVDVVAVGVGPAAAAAGTATALTTAALSGRPYGLVVSAGIGGGFQPDAPLGSVVVADALTVADLGAETPDGFLPVTELGFGTVTHRPPPSLVRDVAAATGALTGTVLTVSTVTGTAVRAAELQRRHPGAAAEAMEGFGVAEAAAAHGVPVLEIRAVSNAVGPRDRAAWRIGDALAALTEAFGKSAPVLESWNRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-09-29" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JQT5</accession>
    <name>A0A2M9JQT5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Peptidase P60</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_24230</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C40 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000010">
        <property type="protein sequence ID" value="PJN09228.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN09228">
        <property type="protein sequence ID" value="PJN09228"/>
        <property type="gene ID" value="CG723_24230"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023346">
        <property type="entry name" value="Lysozyme-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000064">
        <property type="entry name" value="NLP_P60_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008258">
        <property type="entry name" value="Transglycosylase_SLT_dom_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00877">
        <property type="entry name" value="NLPC_P60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01464">
        <property type="entry name" value="SLT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53955">
        <property type="entry name" value="SSF53955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="SSF54001"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51935">
        <property type="entry name" value="NLPC_P60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NlpC/P60" evidence="2">
        <location>
            <begin position="197"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN09228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="340" mass="35697" checksum="9BB77C6CF24E629C" modified="2018-04-25" version="1">MRKAWVVGGALAAGGTGFVTLLVIGTFMAAGSLASGVGKGAVGLAKGAVPSAYQSIVQEWGNLCPAINPALLAAQLYQESGFNPNAKSPAKALGIAQFIPGTWAAHGVDGDGDGDRDIWDPKDAIPSAASYDCSLAKYVKDAPGNQTENMLAAYNAGAYAVIKYGGVPPYRETQNYVKTITNLEKSFARPVGRVQPSQQAAGAIYYAQKKLGTEYLWGGNGTADQGGRFDCSGLTLAAYREVGIELPRVANDQYNAGPHPKRDELLPGDLVFFSDDLTDSRAIRHVGIYVGGGYMIDAPRPGAVIRFDPVDTPDYFGATRVTEDGAKAVPSERPTGNSEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JQT6</accession>
    <name>A0A2M9JQT6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GntR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_24320</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000010">
        <property type="protein sequence ID" value="PJN09230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN09230">
        <property type="protein sequence ID" value="PJN09230"/>
        <property type="gene ID" value="CG723_24320"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07377">
        <property type="entry name" value="WHTH_GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
        <property type="entry name" value="GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00345">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50949">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH gntR-type" evidence="1">
        <location>
            <begin position="12"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN09230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="129" mass="14144" checksum="7A80075B11518AB6" modified="2018-04-25" version="1">MVEYRIDRRSGVATYLQIVQQTQQALRLGLLAPGDKLPTAREVVEATAINPNTVLKAYRELEREGLVEARRGLGTFVRRTLGAASPADSPLRAELADWARRARAAGLDREDAAALFGAVLDENFPKGEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JQV6</accession>
    <name>A0A2M9JQV6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">FAD-binding oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CG723_25255</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000010">
        <property type="protein sequence ID" value="PJN09250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN09250">
        <property type="protein sequence ID" value="PJN09250"/>
        <property type="gene ID" value="CG723_25255"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.45.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016164">
        <property type="entry name" value="FAD-linked_Oxase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004113">
        <property type="entry name" value="FAD-linked_oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016171">
        <property type="entry name" value="Vanillyl_alc_oxidase_C-sub2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02913">
        <property type="entry name" value="FAD-oxidase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13183">
        <property type="entry name" value="Fer4_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55103">
        <property type="entry name" value="SSF55103"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="SSF56176"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="4">
        <location>
            <begin position="42"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PJN09250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="981" mass="105050" checksum="4C19FFA65E1D8602" modified="2018-04-25" version="1">MSATVGNQDPEGIARALRGVVRGEVDFSAAARALMTMDASNYRRVPVGVVAPRDADDVAAVLTVCREHGVPVVARGGGTSIAGQATGTGVVMDFTRHMNRIVSVDPEARTAVVQPGVVLDRLQEAGARHGLRFGPDPSTHSRCTVGGMIGNNSCGSHSVAYGTTADNICYLSSVVRQSNGDFRQRTLGRGWQGAPDSLRPLIEGELALLRTGFPDLPRRISGYAADALLPENGVDLARFLCGTEGTLGIVTEATVRLVEAPRARALAVLAYTDESAAAEAAAGLLPHRPLTVEGMAADLVREQAGLPKGGAWLFVETGGDTAAQARAHAQAIVRAAADGTTDSLVVDDPAGQRALWRIREDASGTATRMPDGTEAWPGWEDCAVPPARLGPYLRDFRGLLAQHGLRGTPYGHFGDGCIHVRIDFDLLSETGVRRFRHFSEDLAELVVAHGGSLSGEHGDGQARAELLPKMYGPELVDLFGRIKDAWDPDGLLNPGILVRPARLDENLRFAVLPRGPVDVEFAYPHDGGDFSAAVRRCVGVAKCRTESAPSGGVMCPSFRVTGEETHSTRGRARLLHEMLAGEVVTDGWQSTEVRDALDLCLSCKGCRTDCPVGVDMATYKAEFLHHHYEGRRRPAAHYSMGWLPRWLRAVHHARVAGVVNTLARVGPLAALGKRLGGIASERKIPRVAPETFSAWWRRDLRRRVQVARRGGAARFGGDGPEVVLWPDTFTEHLAPQVGQAAVRVLEEAGLSVLLPPTRVFDYRPDGLAAVAGLLPSRRGRVCCGLTYVSTGQLDRARAVLRRTLDLMRPVIDSGLPVVVLEPSCAAALRTDLPELLPDAPRARLLADSVLTFAEALERFAPHWDPPRVDRPAVGQTHCHQHAVLGDAAERRLRERAGLEGELSGGCCGLAGNFGFEKGHYDVSAACAEEQLLPAVRAAADDAVVLADGFSCRTQLEQLEREGGRPGRHLAEVLAEALGFSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JQX6</accession>
    <name>A0A2M9JQX6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Acyl-CoA dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CG723_23245</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CB01635</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000009">
        <property type="protein sequence ID" value="PJN09271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN09271">
        <property type="protein sequence ID" value="PJN09271"/>
        <property type="gene ID" value="CG723_23245"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016627">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="SSF47203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="SSF56645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0274">FAD</keyword>
    <keyword evidence="3 5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA_dh_N" evidence="8">
        <location>
            <begin position="14"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_M" evidence="7">
        <location>
            <begin position="130"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_1" evidence="6">
        <location>
            <begin position="241"/>
            <end position="389"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PJN09271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="400" mass="43181" checksum="E0F1CF3EFD415D1B" modified="2018-04-25" version="1">MTIGFEIDDRVADIARRTTDFVRDVVIPEEQACDGNVHTGPEPLRRRLQEAARTAGVFAPHVGTDWGGLGLDLCGQAVVFEAAGHSLLGPLALNCAAPDEGNMHLLEVVATAEQKERYLGRLAAGEVRSCFAMTEPAPGAGSDPRALATTATRIDGGWRIDGRKWFISGADGAGFAICMARTSGGPGDAGGATMFLVDADNPGMKIVRNIDTLDQGLFGGHSEVVFENCEVGADAVLGEVDQGFKYAQVRLGPARMTHCMRWLGVARRAQDIALERAAERSAFGRPLAELGMVQQLLADSEIDIETSRAVLWRACWELDQGRSAAQHTSIAKTYVSEAVNRVVDRAVQVCGALGISGDAPLSRLYREVRPFRIYDGPSETHRWAIAKRAVRTARERRDAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JQZ6</accession>
    <name>A0A2M9JQZ6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CG723_25195</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CB01635</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) family. Azg-like subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000010">
        <property type="protein sequence ID" value="PJN09207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN09207">
        <property type="protein sequence ID" value="PJN09207"/>
        <property type="gene ID" value="CG723_25195"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015205">
        <property type="term" value="F:nucleobase transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904823">
        <property type="term" value="P:purine nucleobase transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045018">
        <property type="entry name" value="Azg-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006043">
        <property type="entry name" value="NCS2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43337">
        <property type="entry name" value="PTHR43337"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00860">
        <property type="entry name" value="Xan_ur_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="39"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="81"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="124"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="155"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="201"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="226"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="283"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="327"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="364"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="390"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="430"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="460"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PJN09207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="481" mass="49932" checksum="BD35D5646856905A" modified="2018-04-25" version="1">MSSSAPAPVDLTEPPSAPQNGLDRFFRISERGSTVSREIRGGFATFFAMAYIIVLNPIILGSAKDMYGHQLDNGQLVTATALTAAFTTLLMGVIGNVPIALAAGLGVNTVVALQLAPRMSWPDAMGMVVLAGFVVMLLVATGLRERVMNAVPLGLRKGIAIGIGLFIMLIGLVDSGFVSRIPDAAHTTVPLQLGADGHLNGWPVLVFVLGVLLTLALIVRKVPGAILISIVVMTLVAMVIDAVANVPSWGLTTPKWPGNPVEMPDFGLVGQVSPFGGFDKVGMLTGILFVFTVLLSCFFDAMGTIMGVSDEAKLTDKSGQMPGMNKVLFIDGIAVAAGGASSSSATTCFVESTAGVGEGARTGFANVITGGLFAVALFLTPIATMVPSQAATPALLAVGFLILSGSIGAIDWSDYTIAIPAFLTMVMMPFTYSITNGIGIGFISFTLLRVAAGRARTVPVAMYIVAAVFAFYYLMPALGLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JRH8</accession>
    <name>A0A2M9JRH8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">ABC transporter substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CG723_22005</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CB01635</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CdaR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000008">
        <property type="protein sequence ID" value="PJN09454.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN09454">
        <property type="protein sequence ID" value="PJN09454"/>
        <property type="gene ID" value="CG723_22005"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2840">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041522">
        <property type="entry name" value="CdaR_GGDEF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025736">
        <property type="entry name" value="PucR_C-HTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042070">
        <property type="entry name" value="PucR_C-HTH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17853">
        <property type="entry name" value="GGDEF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13556">
        <property type="entry name" value="HTH_30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GGDEF_2" evidence="3">
        <location>
            <begin position="182"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="domain" description="HTH_30" evidence="2">
        <location>
            <begin position="351"/>
            <end position="406"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF17853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PJN09454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="421" mass="46799" checksum="93F3787495AAA483" modified="2018-04-25" version="1">MAVGSVAAEECLSAVASNVAAHTPEVSRDVWELVIAEIPQLRGDGIILNTLKASVEENIATLLHGFENVMPLDNVEGPAAALDYARRLAQRNVPISSLIRSYRLGHCRFLQWCLDELRRQGPDEDVCTATARLMLELSFGYIDRVSERVIEVYQLERDRWLLGQTAVRAVRVREILAEKHVDADSAESALGYRIRRHHHVGMVLWLPQRPLGGEGLARLDRLTSRIAEELHCCTEPLFAAREETLAWAWLPFGSPRDLSWDVLASAVEDGDATVRAAVGDVEPGVEGFRRTHRQALRAQELAMVAGPGARVTAYAQVAPIALMCANIEDARAWAWSVLGALAFDDEHCARLRETLQIFLATGCSYTATASQQILHKNTVQYRIRKAEEALGRPLQERRRDLELALLAVQYLGSSFLRTNPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JRR5</accession>
    <name>A0A2M9JRR5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CG723_22715</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000008">
        <property type="protein sequence ID" value="PJN09554.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN09554">
        <property type="protein sequence ID" value="PJN09554"/>
        <property type="gene ID" value="CG723_22715"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046030">
        <property type="entry name" value="DUF5988"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19450">
        <property type="entry name" value="DUF5988"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PJN09554.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="68" mass="7653" checksum="D3482D5E99CA0954" modified="2018-04-25" version="1">MVDAMKAVLEGGPDDLPERIVSVSTPGLDIKVPLRGGYEHFKVTKRQEETSQGLLPVYEWWERTELPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JRV3</accession>
    <name>A0A2M9JRV3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GNAT family N-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_22920</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000008">
        <property type="protein sequence ID" value="PJN09588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN09588">
        <property type="protein sequence ID" value="PJN09588"/>
        <property type="gene ID" value="CG723_22920"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13302">
        <property type="entry name" value="Acetyltransf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="16"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN09588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="183" mass="19875" checksum="4F664243AD4453F4" modified="2018-04-25" version="1">MPELKRLHADHASAVLAFELENRAYFAASVSDRGDTFFNQFTDGYRALLAEQEAGICAFYVLVAEEGSVLGRFNLYDLEDGTARLGYRVAERVAGRGVATATVRELCRLAAARHGLRTLRAATARQNAASQKVLTKAEFVPVGPADPAHLGGEPGTWYQRELVLQPYSTNLLGDRPQGGGGHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JSA9</accession>
    <name>A0A2M9JSA9_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA-binding protein KhpA</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">KH-domain protein A</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">khpA</name>
        <name evidence="2" type="ORF">CG723_21285</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">A probable RNA-binding protein.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the KhpA RNA-binding protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000007">
        <property type="protein sequence ID" value="PJN09738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014176063.1">
        <property type="nucleotide sequence ID" value="NZ_NNBL01000007.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN09738">
        <property type="protein sequence ID" value="PJN09738"/>
        <property type="gene ID" value="CG723_21285"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00088">
        <property type="entry name" value="UPF0109"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015946">
        <property type="entry name" value="KH_dom-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009019">
        <property type="entry name" value="KH_sf_prok-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020627">
        <property type="entry name" value="KhpA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34654">
        <property type="entry name" value="PTHR34654"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54814">
        <property type="entry name" value="SSF54814"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN09738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="79" mass="8674" checksum="68FF39358DBEBC49" modified="2018-04-25" version="1">MLEEALEHLVKGIVDNPDDVQVASRNLRRGRVLEVRVHPDDLGKVIGRNGRTARALRTVVGAIGGRGVRVDLVDVDQVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JST9</accession>
    <name>A0A2M9JST9_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Serine hydroxymethyltransferase</fullName>
            <shortName evidence="7">SHMT</shortName>
            <shortName evidence="7">Serine methylase</shortName>
            <ecNumber evidence="7">2.1.2.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">glyA</name>
        <name evidence="10" type="ORF">CG723_19670</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CB01635</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + glycine + H2O = (6S)-5,6,7,8-tetrahydrofolate + L-serine</text>
            <dbReference type="Rhea" id="RHEA:15481"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15636"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="EC" id="2.1.2.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 7 8">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2 7">Amino-acid biosynthesis; glycine biosynthesis; glycine from L-serine: step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="7">One-carbon metabolism; tetrahydrofolate interconversion.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the SHMT family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.2.1" evidence="7"/>
    <dbReference type="EMBL" id="NNBL01000006">
        <property type="protein sequence ID" value="PJN09949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN09949">
        <property type="protein sequence ID" value="PJN09949"/>
        <property type="gene ID" value="CG723_19670"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00193"/>
    <dbReference type="UniPathway" id="UPA00288">
        <property type="reaction ID" value="UER01023"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004372">
        <property type="term" value="F:glycine hydroxymethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019264">
        <property type="term" value="P:glycine biosynthetic process from serine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035999">
        <property type="term" value="P:tetrahydrofolate interconversion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00378">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00051">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001085">
        <property type="entry name" value="Ser_HO-MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019798">
        <property type="entry name" value="Ser_HO-MeTrfase_PLP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039429">
        <property type="entry name" value="SHMT-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11680">
        <property type="entry name" value="PTHR11680"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00464">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000412">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00096">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4 7" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="6 7 8" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SHMT" evidence="9">
        <location>
            <begin position="22"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="domain" description="SHMT" evidence="9">
        <location>
            <begin position="157"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="7">
        <location>
            <begin position="168"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="47"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="67"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="69"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="76"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="77"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="164"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="219"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="247"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="275"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="282"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="407"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="7 8">
        <location>
            <position position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000412-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PJN09949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="482" mass="51556" checksum="AB82BFA8330EE7B6" modified="2018-04-25" version="1">MSEPTLSTESVAFRSALDVIRAVEPRVADAIGQELADQREMLKLIASENYASPATLLAMGNWFSDKYAEGTIARRFYAGCRNVDTVEALAAEHARELFGARHAYVQPHSGIDANLVAFWAVLAQRVEAPALELAGVRNVNDLSDADWAELRQAFGNQRMLGMSLDAGGHLTHGFRPNISGKMFDQRSYGTDPQTGLVDYEALRATARDFKPLIIVAGYSAYPRLVNFRIMREIADEVGATLMVDMAHFAGLVAGKVLTGDFDPVPHAQIVTTTTHKSLRGPRGGMVLCDDSLAAQVDRGCPMVLGGPLPHVMAAKAVALAEARRPEFRDYAQSVVDNARALAEGLTRRGATLVTGGTDNHLNLIDVATSYGVTGRQAENALLDSGIVTNRNSIPSDPNGAWYTSGIRIGTPALTTRGLGTAEMDEVAGLIDRVLTAAEPGTTSKGAPSKAQHILAEKVSDEVSARASDLLSGFPLYPEVDLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JT30</accession>
    <name>A0A2M9JT30_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MarR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_19575</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000006">
        <property type="protein sequence ID" value="PJN09937.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN09937">
        <property type="protein sequence ID" value="PJN09937"/>
        <property type="gene ID" value="CG723_19575"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000835">
        <property type="entry name" value="HTH_MarR-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023187">
        <property type="entry name" value="Tscrpt_reg_MarR-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01047">
        <property type="entry name" value="MarR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00598">
        <property type="entry name" value="HTHMARR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00347">
        <property type="entry name" value="HTH_MARR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01117">
        <property type="entry name" value="HTH_MARR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50995">
        <property type="entry name" value="HTH_MARR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH marR-type" evidence="1">
        <location>
            <begin position="21"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN09937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="168" mass="18780" checksum="69C0EF3C7EBB83BF" modified="2018-04-25" version="1">MERDWTDGHLARWLPVMPDLDPDVEGAITRAGELTRHLRRIREQALVDVELERFEYDTLHKLAGRGGRAAPSELASDLGLAPASVTGRLDGLERRGLVVRTPSRTDRRRVDVELTEAGHAIWRKAMDRLGGEEHRVLGALDAKERKQLSDLLRRVMVAAESGPGGRRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-09-29" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JTA5</accession>
    <name>A0A2M9JTA5_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Mrr_cat domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_20630</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000006">
        <property type="protein sequence ID" value="PJN10110.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN10110">
        <property type="protein sequence ID" value="PJN10110"/>
        <property type="gene ID" value="CG723_20630"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009307">
        <property type="term" value="P:DNA restriction-modification system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1350.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011335">
        <property type="entry name" value="Restrct_endonuc-II-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007560">
        <property type="entry name" value="Restrct_endonuc_IV_Mrr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011856">
        <property type="entry name" value="tRNA_endonuc-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04471">
        <property type="entry name" value="Mrr_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52980">
        <property type="entry name" value="SSF52980"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mrr_cat" evidence="1">
        <location>
            <begin position="10"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN10110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="807" mass="91705" checksum="0FAC396AA517A2DC" modified="2018-04-25" version="1">MTSPDYDFTDLSPYDFEALLRDLLSAHEGIAFSTYRIGPDGGIDLQARTDSAVVIAQCKHTPQASRAKLISLAAQEMGKSQNFEAEISRYIFITSADITPKTEREIREELTDLAPTVEVHGRGWINALLAMHPDLERRHFKLWLKSSVAIREMLSGGVFLRGESRARRIEENYLRFVHHDICDRAEKSLEVNGIAILQGAPGAGKTAAAEYLILQWWRRGFRVIVDPRTVDNWWSWLADETPTVFFFDDAWGQTRLHDHSSSHHEKDFAEFLASIIQENLRGDRSRVRTKVAVVTSRSLVLHDTRRYSDATNTLLEAVSDALIPVGRLPHDVKSRILFNHVNIAIDNDPVRAQLASYDWWTTTAAHPNYSPRIVEIVTKRRRFESGAQLVAELREALDDPQQIWQSSFDSFSSLEQLLLLILAVSDSQGVERDAVTLRLRDHSLTEISNTIRRLSGNWIERSNEKGTEVYALSDPSQRDFLVRHVARESLACLDLIKHSHSYKDVAALCEQGRPSELEYQPSLFSLEEASLRESLDACTHPLLNSLRAHWASAIKRLESVPRGFLTVPTQAFVDLFTMFIEIVAYHSDRYSGRGWASFNHDGWTESAMRVISALLDDTDMGSFEETLEAVWQIHGTYSKVTRYRVFEGPYQDHMQWIRDTLMMAWYEWDRVGVETFGEARYWSDLAEAVIDDPGFFRAVGFHEGAASVLEDIESFDAEVSFQIESDTHTQDWVAKVEELEELFDCTLQDSRRTLRLRGLLPEKSLAFYAQETAAPDGLPGIDGKGEYRASGTIDALFRSLGKGVHED</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JTD0</accession>
    <name>A0A2M9JTD0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_20555</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000006">
        <property type="protein sequence ID" value="PJN10098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN10098">
        <property type="protein sequence ID" value="PJN10098"/>
        <property type="gene ID" value="CG723_20555"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="14"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN10098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="66" mass="7015" checksum="556A08424CDAFD74" modified="2018-04-25" version="1">MKTLHARPPIAQIRFAAAPQGQDHGRSGAATTAHDRLIGTTHHSSTTIALLREAIALLREAGLPQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JTH9</accession>
    <name>A0A2M9JTH9_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Histidine kinase</fullName>
            <ecNumber evidence="3">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CG723_19595</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CB01635</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="3"/>
    <dbReference type="EMBL" id="NNBL01000006">
        <property type="protein sequence ID" value="PJN10138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN10138">
        <property type="protein sequence ID" value="PJN10138"/>
        <property type="gene ID" value="CG723_19595"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00672">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00304">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="HAMP" evidence="9">
        <location>
            <begin position="169"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="8">
        <location>
            <begin position="238"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="450"/>
            <end position="471"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PJN10138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="471" mass="49899" checksum="EB1D78A80BFED8B8" modified="2018-04-25" version="1">MGMRHYLLANVDAELTSSRTSLQRTGLTLKQIESLSELGIALDKLSPGPNSTDSGASSLPRNETVFVAVDRAGEPITVGTLRPTARQRDLASAVDDPKALATADEPRDVTVHGDPYRAVGARLADGTTVLLATSTANVQTGIHKALRLDIALGTGLLTLLAVLTMIGVSHRMRPLEDMVETASAIADGDLARRVPPHHDTALEVEQLRLALNSMLHQVETAFETRERSSAQLRRFVADASHELRTPLAAIRGYLQLYDKGMLRDPAERTRALGRVHAEADRMSRLVDELLTLARLDQGPELRLRNVDLSRLVREAADDLRVQQPDRPVHVAADGALLVRADESGLRQILGNLLANVRTHTPEDAPVSVSLERADGTVRLCVADEGPGLDEEDAARIFDRFFRAGGGAGSGLGLAIVQGVVSAHGGEVSVRTAPGTGVRVTVVLPGGGGPVGSALAEGDPVSEVPAGAEGIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JTK5</accession>
    <name>A0A2M9JTK5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MarR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_17550</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000005">
        <property type="protein sequence ID" value="PJN10204.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN10204">
        <property type="protein sequence ID" value="PJN10204"/>
        <property type="gene ID" value="CG723_17550"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000835">
        <property type="entry name" value="HTH_MarR-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12802">
        <property type="entry name" value="MarR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00347">
        <property type="entry name" value="HTH_MARR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH marR-type" evidence="1">
        <location>
            <begin position="29"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN10204.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="162" mass="18354" checksum="95BFC365A3F90A01" modified="2018-04-25" version="1">MTFSDPTALPDPWHSLHELLAAMDAEIEQVYVERGIKGVRPRFAYPLIRLAHTGPLTIRELAESLNRSHSAISQTIAAMRKEDLVTSEPGPDARTRRINLTERGRSLVPFLEAEWRATHATVAELDGETPHAMTAVVEEVRRALEQRSMRERIRHHLAEPPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JTN2</accession>
    <name>A0A2M9JTN2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CG723_17800</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000005">
        <property type="protein sequence ID" value="PJN10246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN10246">
        <property type="protein sequence ID" value="PJN10246"/>
        <property type="gene ID" value="CG723_17800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046855">
        <property type="term" value="P:inositol phosphate dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000760">
        <property type="entry name" value="Inositol_monophosphatase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00459">
        <property type="entry name" value="Inositol_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00377">
        <property type="entry name" value="IMPHPHTASES"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PJN10246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="263" mass="26839" checksum="0A79634FDB8192D6" modified="2018-04-25" version="1">MINSSASSDDSVVATAAASAGADVVRSLYGRRLTRIDKGAGDFATAADVEAEKAIVDVIRAARPDDAVVGEEGGQQGTADAARQWLVDPLCGTLNYAVGSMLVAVNVALRDGAAAVADPFSGEVFFTDGTSAWVRRDGVDEPLAPTSATSLVDVNLDPPFIGRPGFRAVDLLAHPAFVERFRPRVVSTTLALAWVAAGKRAAYVTDGGDLTGSVHFAAGIALCRAAGCVVTGIDGAPTGPAGRGLVVAADTETHGELMSMIRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JTQ3</accession>
    <name>A0A2M9JTQ3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Peptide ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_17900</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000005">
        <property type="protein sequence ID" value="PJN10266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN10266">
        <property type="protein sequence ID" value="PJN10266"/>
        <property type="gene ID" value="CG723_17900"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004668">
        <property type="term" value="F:protein-arginine deiminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009446">
        <property type="term" value="P:putrescine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007466">
        <property type="entry name" value="Peptidyl-Arg-deiminase_porph"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31377">
        <property type="entry name" value="PTHR31377"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04371">
        <property type="entry name" value="PAD_porph"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014889851" evidence="2">
        <location>
            <begin position="32"/>
            <end position="385"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN10266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="385" mass="40061" checksum="BAF422034FC4CC66" modified="2018-04-25" version="1">MNDHRAPQSLSHRLLGRRNFLAATGLAAAGAAWTATGGGKALATPVPASGTGFAVPLDTVPHTRTWMAWPDSTVIWGRKLAGVQANIALVAKTIAKYEPVTMCANSAGVSQARSACGSAVTVIGSIPVDDCWIRDSGPVFRTDGAGGLDAVDLNFNGWGNKQTHAKDSLVAGRIAAEVGVQLTSADFVGEGGAVETDGNGTLMATKSSLVNKNRNPGMTTAQIEAAMCDAFGASKVIWFNGVTGRDITDDHVDATSRFLAAGDGLVQIPLATDTDPWSKDARQQYQLLSTSTDADGTPIAVTKLQGPDYSRIRSSDPNFVAAYANYYVCNGAVISAQFGDTRADAGAKALLQRLFPGRTVEQLNIDSLGAGGGGIHCVTQQQPRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JTR0</accession>
    <name>A0A2M9JTR0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Acid--CoA ligase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_17980</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000005">
        <property type="protein sequence ID" value="PJN10281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN10281">
        <property type="protein sequence ID" value="PJN10281"/>
        <property type="gene ID" value="CG723_17980"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043758">
        <property type="term" value="F:acetate-CoA ligase (ADP-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.261">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003781">
        <property type="entry name" value="CoA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043938">
        <property type="entry name" value="Ligase_CoA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032875">
        <property type="entry name" value="Succ_CoA_lig_flav_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016102">
        <property type="entry name" value="Succinyl-CoA_synth-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13380">
        <property type="entry name" value="CoA_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19045">
        <property type="entry name" value="Ligase_CoA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13607">
        <property type="entry name" value="Succ_CoA_lig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00881">
        <property type="entry name" value="CoA_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52210">
        <property type="entry name" value="SSF52210"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CoA_binding" evidence="1">
        <location>
            <begin position="7"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN10281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="684" mass="70750" checksum="2CC9E4E1C0C6181B" modified="2018-04-25" version="1">MTTLDVFRAPESVAVVGATDNPAKWGHWLARGAVAGAHRRRVHLVNTRGGEVLRRRSRPSLDALPEVPDLVAFAVPASALASGVRDAVALGVPGLLAITAGVEDEAAIGDVIAPSATRLLGPNCLGLYDASGELELAWGRFTPGSLAIVSQSGQLGLEIAGMAASAGIGVSRFVSVGSQLDVGAAELLADLAHHEVTRVVAVYLESFGDGERLLDALDRLREAGKPVLLLTVGASKAAQQAARSHTGSMTSGLDVVDAACRTVGAVRVESPVQLVDTAKLLLRSAPVRGRRVAIVADSGGQGAVAADTASRLGLTVVEFSPEVQERLAAQLPPHAAVANPVDLAGAGEEDISTYASTPAALADTSVTDAVVLSGYFGSYGRDIPEHQAAESEVARAIGSLAAERAMPVVVHSMAERTETVRELHAAGVPTFADVEAALRAVATAHRFTRASRPRELRSPGRESQVPLGAGYLAARRLLADAGVPFPPAVGIVPGTPDPRPAMRPLSAPVVLKADWLEHKTEYGGVATGLHDAPALGAAYGDMVARLGPHGYVVEEMDRRTDVVEVIVAARRDPSFGPVVVVGAGGVQAELTQDLALELAPCSHGTAREMIRRLRSWPLLSGWRGKRPVDVDALAAVVVAVSELIADRGDIGEIELNPVRVSPEGALAVDALVIAAPAPDSPSTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-09-29" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JTT1</accession>
    <name>A0A2M9JTT1_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">F5/8 type C domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CG723_18070</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CB01635</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000005">
        <property type="protein sequence ID" value="PJN10295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN10295">
        <property type="protein sequence ID" value="PJN10295"/>
        <property type="gene ID" value="CG723_18070"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000421">
        <property type="entry name" value="FA58C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006103">
        <property type="entry name" value="Glyco_hydro_2_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00754">
        <property type="entry name" value="F5_F8_type_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02836">
        <property type="entry name" value="Glyco_hydro_2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="SSF49785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50022">
        <property type="entry name" value="FA58C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014760769" description="F5/8 type C domain-containing protein" evidence="3">
        <location>
            <begin position="35"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="domain" description="F5/8 type C" evidence="4">
        <location>
            <begin position="445"/>
            <end position="582"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PJN10295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="582" mass="62792" checksum="D465A2CEBF6534C3" modified="2018-04-25" version="1">MQRSRTSRRRLMAPLTAGLLAAGALSLPAQQAQAAGSVVKVTGSQGDWQLTVDGSPYQIKGLTWGPSVADADTYMPDLRSMGVNTIRTWGTDASSKPLFDSAAAHGIKVIAGFWLQPGGGPGSGGCVNYLTDTDYKNKMLDEFPKWVDTYKDNPGVLMWNVGNESVLGLQNCYSGDELEKQRDAYTTLVNDITKKIHAVDPDHPVTSTDAWVGAWPYYKKNAPDLDLYAVNSYNAVCDVKSAWEQGGYTKPYIVTETGPAGEWEVPDDANGVPAEPADQAKADGYTKAWGCITGHKGVALGATMFHYGTEYDFGGIWFNLLPAGQKRLSYYTVKKAYGADTSHDNTPPVISEMNVEGDAAKVPAGGNLTLATRATDPEGDRISYEVLTNSNYIDASKQLTPVPFTDLGGGRFKVTAPDRPGVWKIYVKATDGKGNVGVETRSVRVVPPPVDGTDIALGKPATASSFQPGSGDCPCTAANAFDGKNDTRWASDWSDPQWLQVDLGSRQSFRHVQLNWETSYAKAYTIQTSDDGQSWRTVHEETAGNGGIDDFDVDGTGRYVRVNGTARGTGYGYSLYEFGVYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-06-02" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JTV1</accession>
    <name>A0A2M9JTV1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_18200</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000005">
        <property type="protein sequence ID" value="PJN10315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN10315">
        <property type="protein sequence ID" value="PJN10315"/>
        <property type="gene ID" value="CG723_18200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="69"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="69"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN10315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="91" mass="10007" checksum="43614122C0A004DA" modified="2018-04-25" version="1">MAHTFDELVERQQAANAAHHEVLRLRDGYGPPGLEPPSESQTQTYETAWRAWRDLARDVQQAVTEYAKEEGLARTDVEADVKAKAGGGEGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-09-29" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JUA4</accession>
    <name>A0A2M9JUA4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CG723_19055</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CB01635</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000005">
        <property type="protein sequence ID" value="PJN10454.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN10454">
        <property type="protein sequence ID" value="PJN10454"/>
        <property type="gene ID" value="CG723_19055"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="39"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="74"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="106"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="132"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="168"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="194"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="226"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="258"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="294"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="330"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="360"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="385"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="420"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="458"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="7">
        <location>
            <begin position="40"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="7"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PJN10454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="494" mass="49206" checksum="DD2EDF201E3B5E4F" modified="2018-04-25" version="1">MGAADASTASSDAQSGTSTSKAEAGSGASGPATGRTGSATAWIVSAGVFVVNLDLFIVNVAVPALSTSFDGASLASLSWVLNAYAIVFAALLVAAGRLADRYGHRLGFLLGLAVFTVASALCAVAPDVGWLVAARALQAAGAAALMPTSLALLLVATPAERRPRAIRGWAAIGGIAAGLGPVAGGLLVEADWRWVFLVNVPVGIAGLVAGVRLLPADRPDRSGPLPDLAGAVLLTLAIGSLALGLVKAEAWGWSSGRVLGSLAAAVILAAAFWLRSARHPVPIVELPLLRIPAFAFATLAALLFTVAFAAMLLTSVLWCQQVWSYSAIRTGLAIAPGPLVVPVLAVASGPVVRRLGAGRAAAAGCLLFAGGLVWWALALDTSPHYAAAFLPGMLITGVGVGFALPTLVGAAATALPPGRFATGSAVTTMARQTGSVLGVAVMVGLIGEPRTAEAALTAFRHGWLTAAVVGALAVAAALALPRPAPAASPAKAPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JUB9</accession>
    <name>A0A2M9JUB9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_17990</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000005">
        <property type="protein sequence ID" value="PJN10485.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN10485">
        <property type="protein sequence ID" value="PJN10485"/>
        <property type="gene ID" value="CG723_17990"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043531">
        <property type="term" value="F:ADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002182">
        <property type="entry name" value="NB-ARC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041617">
        <property type="entry name" value="TPR_MalT"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00931">
        <property type="entry name" value="NB-ARC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17874">
        <property type="entry name" value="TPR_MalT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NB-ARC" evidence="1">
        <location>
            <begin position="23"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="domain" description="TPR_MalT" evidence="2">
        <location>
            <begin position="401"/>
            <end position="565"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF17874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN10485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="674" mass="73679" checksum="8E19DE208ED538B0" modified="2018-04-25" version="1">MTTSFVGRDSELAAVGRALKEHRLVTLTGSGGVGKSRLALRAAEEVRGAYADGAWWADVSHLYDDRLFTATVCDAVGLLDHNPRAPIDALSEWLAGRRVLLVLDCCERVLDACWELVTELLTAAPNLTVLATSRQPLAVREEHCIEVAPLSTGDDEGGCDEAELLFRERCATAAPDVPLDSPGAAETISRICRRLEGIPLAVELACARLRENSLDEIAGRLTSRLDTLVDDTIWPKRHRALRTAIGWSHELCAPLERLVWARLSVFHGPVDETDARSVCAGGPLGTDEIPKILERLADQSVLQRDGTRFRMLDTVREYGALWLDELGEQRTLAGRHAAHFAGIVEQAEAGWLSDRQVAWYTRISDSHADVRAALDHLFTTNADTAVEMAGRTGLFWPCCGHLHESRDYLERALRLDTPRGPSRTRALWALGITLTLQGDHRTALRVGEQCALAAQEDDTPESVLFAAHTLGLTHLMTGHPQDAYDVSEHALNTHASTPPTGAPQLCCLVIRAFALSALGRLDEAHEKATSLRRLSHEYGEHWARSYADHQLAFINLLQGRPHEAEIHARAMLTSKHNLNDNLGIALGLDLLTGANAAQGNGVEAARTSGTGHAYWRMLGHPNRGTPELSEIRDQWEQQARKAAGDSAYDTAYHRALTDDAEHGLAHALQGHAGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JUL5</accession>
    <name>A0A2M9JUL5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Sporulation protein SsgA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CG723_15290</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CB01635</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell septum</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SsgA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000004">
        <property type="protein sequence ID" value="PJN10581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN10581">
        <property type="protein sequence ID" value="PJN10581"/>
        <property type="gene ID" value="CG723_15290"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030428">
        <property type="term" value="C:cell septum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030435">
        <property type="term" value="P:sporulation resulting in formation of a cellular spore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.31.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006776">
        <property type="entry name" value="SsgB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038658">
        <property type="entry name" value="SsgB_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04686">
        <property type="entry name" value="SsgA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0749">Sporulation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PJN10581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="159" mass="17670" checksum="687DCBDE4CD683A8" modified="2018-04-25" version="1">MHTVVERELELRLVLSPERSIPVPARLTYRTDDPYAVHIAFHIGSENPVDWTFARELLVEGVFRPCGHGDVRVWPTKVDRRSVVLMALSSPDGDALLEAPAAAVSSWLERTLRVVPPGSESERLGIDDGLAELLAPTPGRADELWLRDPWPSDESKDGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-09-29" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JUZ1</accession>
    <name>A0A2M9JUZ1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Sugar hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CG723_15935</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000004">
        <property type="protein sequence ID" value="PJN10690.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN10690">
        <property type="protein sequence ID" value="PJN10690"/>
        <property type="gene ID" value="CG723_15935"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030247">
        <property type="term" value="F:polysaccharide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.290">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001919">
        <property type="entry name" value="CBD2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008965">
        <property type="entry name" value="CBM2/CBM3_carb-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012291">
        <property type="entry name" value="CBM2_carb-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001223">
        <property type="entry name" value="Glyco_hydro18_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00553">
        <property type="entry name" value="CBM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00704">
        <property type="entry name" value="Glyco_hydro_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00637">
        <property type="entry name" value="CBD_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49384">
        <property type="entry name" value="SSF49384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51173">
        <property type="entry name" value="CBM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51910">
        <property type="entry name" value="GH18_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014650735" evidence="2">
        <location>
            <begin position="39"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="domain" description="CBM2" evidence="3">
        <location>
            <begin position="34"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="domain" description="GH18" evidence="4">
        <location>
            <begin position="199"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="143"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="151"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PJN10690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="493" mass="49790" checksum="D8E6A39C519760E0" modified="2018-04-25" version="1">MSSTHRRRVSGRNKAIGGLVAAAVVGGGAFLFSGTAQAAGVGAAYTKTSEWSGGYTAQYVVKNDSDKAQSDWKLEFDLPSGTKLGSLWNAESSVSGSHVTVKPASWDKEGIAAGKSVTVGFVVTGDSDPAGCLINGAKCSVDDGATPEPSGRPTESATPTPSASASASATAKPTATATSTAGPSPSSSSGTGSGTTAAGGFAPYVDTSLYPKFDLVASSKATGVKEFNLAFITSGGSCTPKWGGVTDLGSDEVAAQIGDLRASGGDVRVSFGGASGTELAQACSSASDLAAAYQKVIDQFKLTKVDFDVEGGALPDTAANTKRAQAIATLQKNNPELNVSFTLPVMPEGLTSDGVNFLKNAKSNGVSTDLVNIMAMDYGASYSGDMGTYAEQAATATQAQIKSALGLSDAAAWKAVAVTPMIGVNDVSSEIFKVDDATQLVTFAKEKGLGGLSMWSATRDKACEGGASNSAQPTCSSIEQSANAFQKAFASFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JV04</accession>
    <name>A0A2M9JV04_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Sensor histidine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CG723_15785</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000004">
        <property type="protein sequence ID" value="PJN10668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN10668">
        <property type="protein sequence ID" value="PJN10668"/>
        <property type="gene ID" value="CG723_15785"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025828">
        <property type="entry name" value="Put_sensor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011712">
        <property type="entry name" value="Sig_transdc_His_kin_sub3_dim/P"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07730">
        <property type="entry name" value="HisKA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13796">
        <property type="entry name" value="Sensor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="22"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="49"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="115"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="168"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="domain" description="Sensor" evidence="3">
        <location>
            <begin position="25"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="domain" description="HisKA_3" evidence="2">
        <location>
            <begin position="232"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PJN10668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="421" mass="43763" checksum="9E95B376A96EFF58" modified="2018-04-25" version="1">MTSLAASPRGPSYLRGSAPWRAAGYLAGGVLVGAPLLVTFVTLGVAGAVLSLVLVGLPLLALLSLAGVPVGALERRRLRPVTGQAAPSPHRTPAEPGATAWLRLRLGEQATWRELAYAALLALVLWPLDLLVLICTIGLAGAVAAAPVQLVSAGHDTRVVKLWLIDSYWQAGLCAVAGLALLAVLLYPLGAYAAARAALARLLLAPRETEEEARLAEVTRSRARLVAAFEAERRRIERDLHDGAQQRLVALTMSLGLARLDAPATGPLAEHIATAHEEAGQVLVELRELIHGIHPQVLADYGLAAALDDAADRSAVPVDTRIDLPRLPGPVESAAYFAVCEALANTAKHSGADRVVLTARHERGRLVIDVQDDGGGGADPARGSGLTGLADRLAVLDGTLTIISPAGGPTALSLEIPCPAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-06-02" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JV62</accession>
    <name>A0A2M9JV62_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_16170</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000004">
        <property type="protein sequence ID" value="PJN10728.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN10728">
        <property type="protein sequence ID" value="PJN10728"/>
        <property type="gene ID" value="CG723_16170"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004104">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02894">
        <property type="entry name" value="GFO_IDH_MocA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GFO_IDH_MocA" evidence="1">
        <location>
            <begin position="50"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="domain" description="GFO_IDH_MocA_C" evidence="2">
        <location>
            <begin position="154"/>
            <end position="379"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN10728.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="385" mass="42813" checksum="A5A229EBB6AB98A7" modified="2018-04-25" version="1">MTRKTVRIAMNGVTGRMGYRQHLVRSLLALREQGGLDLGDGTVLWPEPVLVGRREHALLALAERHGLDPANVSTDLDAVLADDTIDIYFDGQVTSAREEALKKAIAAGKHLYTEKPSATSLDGALELARLAKAKGIKHGVVQDKLFLPGLLKLKRLIDGGFFGRILSVRGEFGYWVFEGDWQEAQRPSWNYRSEDGGGIVVDMFPHWEYVLHELFGRVTSVQALASTHIPQRWDEGGKPYDATADDSAYGIFELDGGAVAQINSSWSVRVNRDELVEFQVDGTEGSAVAGLRNCRVQHRAATPKPVWNPDLPATYSFRDQWQEVPDNQEFDNGFKAQWELFLKHVYADAPYRWDLFAGARGVQLAELGLKSSAEGRRLDVPEISL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-09-29" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JVU5</accession>
    <name>A0A2M9JVU5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_08530</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN11025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN11025">
        <property type="protein sequence ID" value="PJN11025"/>
        <property type="gene ID" value="CG723_08530"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030077">
        <property type="term" value="C:plasma membrane light-harvesting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045156">
        <property type="term" value="F:electron transporter, transferring electrons within the cyclic electron transport pathway of photosynthesis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019684">
        <property type="term" value="P:photosynthesis, light reaction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.50.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014747">
        <property type="entry name" value="Bac_photo_RC_H_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011033">
        <property type="entry name" value="PRC_barrel-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50346">
        <property type="entry name" value="SSF50346"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="121"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="136"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN11025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="161" mass="16773" checksum="11F82B23C1E0D136" modified="2018-04-25" version="1">MQSAPPGRKRLKYGGATMTENIWSYPASAGHTQNADLTGYKVEATDGHIGKVDKHSNDVGSQYIVVDTGVWIFGKEVLLPAGTITGIDAEATTIQVARTKDQIKSAPEFDKDKHLGDAGYHEQVGTYYDAPGTPGTPGTPGTPGTPGTPGAGPTPPGRPTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JWA8</accession>
    <name>A0A2M9JWA8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Peroxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CG723_09095</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CB01635</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the DyP-type peroxidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN11112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN11112">
        <property type="protein sequence ID" value="PJN11112"/>
        <property type="gene ID" value="CG723_09095"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004601">
        <property type="term" value="F:peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006314">
        <property type="entry name" value="Dyp_peroxidase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01413">
        <property type="entry name" value="Dyp_perox_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51404">
        <property type="entry name" value="DYP_PEROXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2 4" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00025737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PJN11112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="456" mass="49639" checksum="E0A8D4B6DE6747CA" modified="2018-04-25" version="1">MEAQASMNTAASSSAASVRVEIDDVQSGALRPRPVPYEGKFIFLRVDDRHAGRALLRRLLPVTAGGLPSVDPSRDAWVAVAFTYQGLRALGVPQESLDSFPRAFREGMAARAELIGDVGESAAAHWEAPFGTGDVHIALSALSSDAAQLDKELERARVAYEDTPGVQVIWQQEVHQLPTGRTTFGFRDGISHPNIEGVGLPGSNPQEIPIKAGEFILGYPDETGNLPPMPSPDVLGRNGTYAAVRKVHTNVAAWRQYLRANTSSAEEEALLAAKMVGRWPSGAPLTLTPEHDDPELAADPHRVNNFLYRENDDRGLRCPAGAHIRRTNPRDSTIIGDARMHRLIRRGTTYGPPLPDGVLEDDGADRGLVGVFLGAHLERQFEFIKAEWVNDGNFIGYPGEKDPVAGHHGGTGSVTIPEKPVRRRLKNLPSFVVTRGGEYCFVPGLRALRWLAELED</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JWN5</accession>
    <name>A0A2M9JWN5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CG723_10255</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN11305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN11305">
        <property type="protein sequence ID" value="PJN11305"/>
        <property type="gene ID" value="CG723_10255"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016857">
        <property type="term" value="F:racemase and epimerase activity, acting on carbohydrates and derivatives"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008000">
        <property type="entry name" value="Rham/fucose_mutarotase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05336">
        <property type="entry name" value="rhaM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PJN11305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="103" mass="11600" checksum="FE595C3371896E8A" modified="2018-04-25" version="1">MRIALHTKVRADRVDAYEAAHREVPAELRKAIRAAGATSWTIWRSGTDLFHVLECEDYARMLAELDKLPVNIAWQARMAELLDVVHDYSADGADAGLPVVWEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JWT6</accession>
    <name>A0A2M9JWT6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Acyl-CoA thioesterase II</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_10545</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the C/M/P thioester hydrolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN11356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN11356">
        <property type="protein sequence ID" value="PJN11356"/>
        <property type="gene ID" value="CG723_10545"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047617">
        <property type="term" value="F:acyl-CoA hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006637">
        <property type="term" value="P:acyl-CoA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.210">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042171">
        <property type="entry name" value="Acyl-CoA_hotdog"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003703">
        <property type="entry name" value="Acyl_CoA_thio"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11066">
        <property type="entry name" value="PTHR11066"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="SSF54637"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN11356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="288" mass="31305" checksum="C0163600EF4F66B3" modified="2018-04-25" version="1">MINRVLEQAQPFGPLGKGERLALEDVGSGVLQGYCHAGRAPRRAYGGAVVGQALAAAYRTVEGDRAVHSMHAYFLRPVAPERPARYVSDVVRDGWSYSVRQVTATQDGKDALTMSVSFKLPQQDGSWRQPGMPEVPGPEDLDDGFSSRPATHPLRTAVEYRKVPDVHGADEGQIERFGWFRAVGALPDDPALHACALAYISDAPLAPTALVPYGEPRPAGVVLASLDHAMWFHRPFRADAWLLYACSSRLAGDGRTLAYGEFWDRDGQLVASVVQEALLRMPEESGPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JXG9</accession>
    <name>A0A2M9JXG9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_11545</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN11528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN11528">
        <property type="protein sequence ID" value="PJN11528"/>
        <property type="gene ID" value="CG723_11545"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014902912" evidence="1">
        <location>
            <begin position="35"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN11528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="76" mass="7972" checksum="A2986DC4D77C45C3" modified="2018-04-25" version="1">MNATRSAELAAAQACLRLLHTARAALTGCEPATAASLLALPIAEADEALDRAGLAGNEAWLLEKLYDLGTEKRVHT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JXR9</accession>
    <name>A0A2M9JXR9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">ADP-ribosylglycohydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CG723_12205</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN11638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN11638">
        <property type="protein sequence ID" value="PJN11638"/>
        <property type="gene ID" value="CG723_12205"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.4080.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005502">
        <property type="entry name" value="Ribosyl_crysJ1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036705">
        <property type="entry name" value="Ribosyl_crysJ1_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03747">
        <property type="entry name" value="ADP_ribosyl_GH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101478">
        <property type="entry name" value="SSF101478"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PJN11638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="391" mass="41703" checksum="F344F2F5AE2FD447" modified="2018-04-25" version="1">MELTVHTRSWADLAVHRSRVRGCLLGGAIGDAIGYPVEFLSLDAIRATHGAAGVTGLVPDADGVTGRVSDDTQMTLFTAEGHLRGYCRTRDRGIGGAEAQIVRDAYLRWLETQNHPGPPPEEDLRHRIGWLRHEPWLYARRAPGNACLSGIEAGFAPDPYGKPTGEPGPVNPNSKGCGAVMRSAPFGLTDLGARRSFELAAQCAQITHGHPTGYLASGAFAALISHLVDGESLEGAVLRTLRLLAGYRGHEETTAALSRAVALADEEGEATPERVETLGAGWVAEEALAIGVYAVMARTRPQTFYVGKEGTVCNPKPPRTPIEAAFLLSVNHSGDSDSTGSLCGNILGALHGDVHLPHQWLTAIEGRTAVARLGDDIAAEIRHGEKRPWNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JXU7</accession>
    <name>A0A2M9JXU7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Carboxymuconolactone decarboxylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_12580</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN11694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN11694">
        <property type="protein sequence ID" value="PJN11694"/>
        <property type="gene ID" value="CG723_12580"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051920">
        <property type="term" value="F:peroxiredoxin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029032">
        <property type="entry name" value="AhpD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003779">
        <property type="entry name" value="CMD-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02627">
        <property type="entry name" value="CMD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69118">
        <property type="entry name" value="SSF69118"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CMD" evidence="1">
        <location>
            <begin position="27"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02627"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN11694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="159" mass="17881" checksum="3DFEFBCDCDBF83AE" modified="2018-04-25" version="1">MIIDIPEGQEPIGYVWGDMVPGIGMAAANFSLSVYAHTTLGLREFEAARLRIAQINGCQFCLDWRTDRDGEKVEESFADAVTEWRTSDAFDDRTRLAAEYAERYALDHHGLDEEFWSRMTALYSQVEIVELSMSIGSWLAFGRLNHVLGLDTVCVLPTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JY28</accession>
    <name>A0A2M9JY28_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CG723_12470</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CB01635</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN11677.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN11677">
        <property type="protein sequence ID" value="PJN11677"/>
        <property type="gene ID" value="CG723_12470"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="37"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="79"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="145"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="184"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="31"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PJN11677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="227" mass="23481" checksum="E030C5E29AFC9C4A" modified="2018-04-25" version="1">MGPDAEDRLMHTFFASFSFMADHFGLLADRTVDHLKLSAAAVAVALVLALPLGVWLGHRGKGSFLTVSISNIGRALPSLALIAIFLGLLGIGFVNVLTALVVMAVPPVLTHAYLSVEQVDPDLVRAGRGMGLTEWQILTRIELPLALPVLFTGIRIAAVYVISSATLAAVAGGGGLGDIILNQVSYGLSGVIAAALWVAVLALAADALFGALRSRLTPHGVLAGRSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JY94</accession>
    <name>A0A2M9JY94_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Pirin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CG723_13355</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CB01635</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the pirin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN11824.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN11824">
        <property type="protein sequence ID" value="PJN11824"/>
        <property type="gene ID" value="CG723_13355"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012093">
        <property type="entry name" value="Pirin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008778">
        <property type="entry name" value="Pirin_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003829">
        <property type="entry name" value="Pirin_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13903">
        <property type="entry name" value="PTHR13903"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02678">
        <property type="entry name" value="Pirin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05726">
        <property type="entry name" value="Pirin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006232">
        <property type="entry name" value="Pirin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pirin" evidence="4">
        <location>
            <begin position="45"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="domain" description="Pirin_C" evidence="5">
        <location>
            <begin position="197"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="303"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF05726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PJN11824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="329" mass="35530" checksum="AA3F2A3EBD58427E" modified="2018-04-25" version="1">MSNAEAGPVGVHGGSRVAGELSAEGQRVDVLAPRDVPLGGPRAMTVRRTLPQRSRTLIGAWCFADHYGPDDVGRTGGMDVAPHPHTGLQTVSWLFSGEIEHRDSLGSHAYVRPGELNLMTGGHGISHSEVSTPRTTTLHGVQLWVALPEEHRHTGRDFQHHVPEPVRTEGAEIRVFLGALAGSVSPVPTFTPLLGAEITLAARASLTLAVDADFEHGVLVDHGDVRVADTLLRPADLGYVHPGADTLTLVNESDETARTVLLGGTPFEEEIVMWWNFIGRTHEDIVRAREEWESASERFGAVEGYPGDRLPAPALPHATLAPRKNPPRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JYE1</accession>
    <name>A0A2M9JYE1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Gluconate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_13715</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN11882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN11882">
        <property type="protein sequence ID" value="PJN11882"/>
        <property type="gene ID" value="CG723_13715"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015128">
        <property type="term" value="F:gluconate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003474">
        <property type="entry name" value="Glcn_transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30354">
        <property type="entry name" value="PTHR30354"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02447">
        <property type="entry name" value="GntP_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002746">
        <property type="entry name" value="Gluconate_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00791">
        <property type="entry name" value="gntP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="30"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="106"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="148"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="187"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="266"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="296"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="341"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="378"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="419"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="461"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="235"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN11882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="481" mass="48868" checksum="87F58DBE9864661E" modified="2018-04-25" version="1">MTSHTWYLLLVLAVAIGLLIYLINSRLRIHPFIALMVVTIGTGLAAGEPVAKLTGSIEEGAGGTLGDIGLTLALGAMLGRLLSDSGATDAIAHAIVDRSSNRRLPWLVAAAAFVIGIPMFFEVGLIVLLPLIFSVARRLEGDGATKGSPYVLLGVPAIAALSTLHGMVPPHPGPLTAMTGLHADLGLTLGVGIICSIPTVILAGPVYARWIAPRLADVRPDPVLVAQFTGADRNNAADTTTNASSTGPAEGTDIDTLQRAGVSTGLAVTSVLIPVALMLLRTLAETALDESSTVRAALTFVGEPLVAMLAGFLFALGVTLVRGGRSSEATRSSLTDSLKSIAAILLIIGGGGAFKQVLQDSGIGDAIASAAEGAHLNVIVLGWLIALLLSLTTGSATVGIVSATGIVAPLIGTGGGLEASLLVVAIGAGSLGLNYVNHAGFWLVKESFGMDLTQATKTQTVVQTLVSVMGLGMALLLSVLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JZA9</accession>
    <name>A0A2M9JZA9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CG723_13945</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CB01635</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN12223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN12223">
        <property type="protein sequence ID" value="PJN12223"/>
        <property type="gene ID" value="CG723_13945"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006865">
        <property type="term" value="P:amino acid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010065">
        <property type="entry name" value="AA_ABC_transptr_permease_3TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043429">
        <property type="entry name" value="ArtM/GltK/GlnP/TcyL/YhdX-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30614">
        <property type="entry name" value="PTHR30614"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01726">
        <property type="entry name" value="HEQRo_perm_3TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="46"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="93"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="120"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="225"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="7">
        <location>
            <begin position="48"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PJN12223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="254" mass="27190" checksum="59FB1CA0DF05BBCD" modified="2018-04-25" version="1">MLRGAQYVVLTGAVIAVAVLADWHQLQQQFLELSVAKRMFPDLLTVALANTVAYTLSGFGVGLVLGLVIALMRLSSVAPYRWLASLYIEVFRGLPALLIFIFIGVGVPLAFPGLAIPGGAYGQVAVALGLVAAAYMAETIRAGIQAVPRGQMEAARTLGMSHARAMWSIVIPQAFRIIVPPLTNELVLLFKDSSLVLFLGVSLQTRELTKFGRDLASETANTTPIFVAGLCYLLITVPLGYVVRLLEAGHAKAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JZC4</accession>
    <name>A0A2M9JZC4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Protein phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_13770</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN12216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN12216">
        <property type="protein sequence ID" value="PJN12216"/>
        <property type="gene ID" value="CG723_13770"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07228">
        <property type="entry name" value="SpoIIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00331">
        <property type="entry name" value="PP2C_SIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="SSF81606"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="42"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="69"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="domain" description="PPM-type phosphatase" evidence="2">
        <location>
            <begin position="122"/>
            <end position="345"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN12216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="354" mass="38071" checksum="75237239EF8988B7" modified="2018-04-25" version="1">MLPLALIVVITVVDILVPADVHLGPLLVVAPALTASFAGPRLTAFIGALAIGAQIFIGIHFGVLTTRNVMVQVFSLTVLSALIAFFCRVREHRKRELAKVRSVAEAAQKALLRPLPHRIGPLRIASLYLAAEDEAVIGGDLYTATGTDDGVRVIIGDVRGHGLSAVGESAQLLGAFRVVADQHATLPALAGALDRSVSRYLTDFVEAEDGIDEHFITALLLEIPDDGHMTRMTCCGHPPPLLLHEHHVRTLTTAHPAPPLGVAALPAAQFPVEEFAFDAGDTLILYTDGVTEARDENGVFFPLAQRVEQWAENRPEALLDRLRRDLLAHCQGHLGDDAAVIAIQRTPAARPDRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JZG0</accession>
    <name>A0A2M9JZG0_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="12 13">DNA primase</fullName>
            <ecNumber evidence="12">2.7.7.101</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">dnaG</name>
        <name evidence="17" type="ORF">CG723_04210</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">CB01635</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12 13">RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12 13 14">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="12 13 14">Binds 1 zinc ion per monomer.</text>
    </comment>
    <comment type="subunit">
        <text evidence="12">Monomer. Interacts with DnaB.</text>
    </comment>
    <comment type="domain">
        <text evidence="12">Contains an N-terminal zinc-binding domain, a central core domain that contains the primase activity, and a C-terminal DnaB-binding domain.</text>
    </comment>
    <comment type="similarity">
        <text evidence="12 13">Belongs to the DnaG primase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.101" evidence="12"/>
    <dbReference type="EMBL" id="NNBL01000002">
        <property type="protein sequence ID" value="PJN12273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN12273">
        <property type="protein sequence ID" value="PJN12273"/>
        <property type="gene ID" value="CG723_04210"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000428">
        <property type="term" value="C:DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990077">
        <property type="term" value="C:primosome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003896">
        <property type="term" value="F:DNA primase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03364">
        <property type="entry name" value="TOPRIM_DnaG_primases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.980.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00974">
        <property type="entry name" value="DNA_primase_DnaG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013264">
        <property type="entry name" value="DNA_primase_core_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037068">
        <property type="entry name" value="DNA_primase_core_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019475">
        <property type="entry name" value="DNA_primase_DnaB-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006295">
        <property type="entry name" value="DNA_primase_DnaG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013173">
        <property type="entry name" value="DNA_primase_DnaG_DnaB-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036977">
        <property type="entry name" value="DNA_primase_Znf_CHC2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030846">
        <property type="entry name" value="DnaG_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034151">
        <property type="entry name" value="TOPRIM_DnaG_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006171">
        <property type="entry name" value="TOPRIM_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002694">
        <property type="entry name" value="Znf_CHC2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10410">
        <property type="entry name" value="DnaB_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08278">
        <property type="entry name" value="DnaG_DnaB_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13662">
        <property type="entry name" value="Toprim_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08275">
        <property type="entry name" value="Toprim_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01807">
        <property type="entry name" value="zf-CHC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002811">
        <property type="entry name" value="DnaG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00766">
        <property type="entry name" value="DnaG_DnaB_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00493">
        <property type="entry name" value="TOPRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00400">
        <property type="entry name" value="ZnF_CHCC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01391">
        <property type="entry name" value="dnaG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50880">
        <property type="entry name" value="TOPRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 12 13" id="KW-0235">DNA replication</keyword>
    <keyword evidence="10 12" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1 12 13" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6 12 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 12 13" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="2 12 13" id="KW-0639">Primosome</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11 12 13" id="KW-0804">Transcription</keyword>
    <keyword evidence="3 12 13" id="KW-0808">Transferase</keyword>
    <keyword evidence="8 12 13" id="KW-0862">Zinc</keyword>
    <keyword evidence="7 12 14" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Toprim" evidence="16">
        <location>
            <begin position="261"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="CHC2-type" evidence="12 14">
        <location>
            <begin position="41"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="443"/>
            <end position="463"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRNR" id="PIRNR002811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR002811-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="PJN12273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="632" mass="68822" checksum="647AD1150E4906B6" modified="2018-04-25" version="1">MAGRINDEDVKAVRDAVPIDAVVSEYLQLRNAGGGNLKGLCPFHDEKSPSFQVSPSKGFFHCFGCQEGGDTITFVMKVDHLSFSEAVERLAGQAGITLRYEEGGYNPSHQRGERIRLVEAHKAAAQFYMDQLESAEAEIGRKFLAERGFDQAAAAHFGVGYSPAGWDHLTRFLRGKGFTDKELITSGIAQEGRRGPIDRFRGRLMWPIRDIGGEVVGFGARRLRDDDNGPKYLNTPETPIYKKSQVLYGIDLAKKDIAKSSRAVVVEGYTDVMACHLAGITTAIATCGTAFGGDHIKILRRLLMDNGSARVIFTFDGDSAGQKAALRAFEDDQKFAAETYIAVAPDGMDPCDLRLAKGDEAVADLVEPRTPLFEFALRHIVSRYDLETPAGRASALDEAAPVVARIKNSGAQHEVAVQLAGMLGILDTQFVVKRVSQLARWARDRGGRGPAPARPQQSYEAAATRASAAGPALTLRNPVYATERELLKLALQRPELVSPAFDAYGVDEFTAAPYAAVREAIIEAGGADLGTQDPQAYLVRVREVAPDDAVRAMVTELAVEAILRRSVDEVYAGQQLVAVRRRAVDRRIRDVQGSLTRLGTHGDPARLSAVQEELMVLQRYDRALQDLGAQAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JZH5</accession>
    <name>A0A2M9JZH5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Potassium transporter TrkA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_11405</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN12157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN12157">
        <property type="protein sequence ID" value="PJN12157"/>
        <property type="gene ID" value="CG723_11405"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008324">
        <property type="term" value="F:cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006813">
        <property type="term" value="P:potassium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026278">
        <property type="entry name" value="K(+)/H(+)_antiporter_KhtT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006037">
        <property type="entry name" value="RCK_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036721">
        <property type="entry name" value="RCK_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02080">
        <property type="entry name" value="TrkA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005028">
        <property type="entry name" value="KhtT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF116726">
        <property type="entry name" value="SSF116726"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51202">
        <property type="entry name" value="RCK_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RCK C-terminal" evidence="1">
        <location>
            <begin position="71"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN12157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="156" mass="16665" checksum="853693F03A24A423" modified="2018-04-25" version="1">MSRTPLPGIGFRYDLTTRDQRQVSVVAHRDGGRTLSAYRTDDPDACDLSLKLTSGEAAALIDALMPSHHSPNLLHTTDLGLVAERIEIGATSHWNGRLLGETQLRTETGASIVAVLRRAEAIPSPTPDFRLAGGDTVIVIGTREGVEAAATILGRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JZM9</accession>
    <name>A0A2M9JZM9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">PucR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CG723_04525</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CB01635</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CdaR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000002">
        <property type="protein sequence ID" value="PJN12326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN12326">
        <property type="protein sequence ID" value="PJN12326"/>
        <property type="gene ID" value="CG723_04525"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2840">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041522">
        <property type="entry name" value="CdaR_GGDEF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025736">
        <property type="entry name" value="PucR_C-HTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042070">
        <property type="entry name" value="PucR_C-HTH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17853">
        <property type="entry name" value="GGDEF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13556">
        <property type="entry name" value="HTH_30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GGDEF_2" evidence="4">
        <location>
            <begin position="177"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="domain" description="HTH_30" evidence="3">
        <location>
            <begin position="336"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF17853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PJN12326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="404" mass="43223" checksum="106E6E5EBEB0F84A" modified="2018-04-25" version="1">MPEPSANEAPDHRDRRANPHPHSATLKRLEKSSGSLAAQAITRMDETLPWYRAMPPENRSWIGLVAQAGIAAFTEWFRHPDAPQAISTDVFGTAPRELTRAITLRQTVEMVRTTIEVMESAIDEVAAPGDESILREALLVYAREIAFATAQVYAQAAEARGAWDARLESLVVNAVLSGEADEGAVSRAAALGWNSPEHVCVVLGTAPDGDSELTVEAIRRAARHAKLQVLTGVLGDRLVVIAGGNNNPLQVAKSLIGPYAAGPVVAGPVVPDLLAATRSAQAAAAGLKACGAWQDAPRPVLADDLLPERAIASDPAAREQLVEEIYRPLEEAGSALLETLSVYLEQASSLEGAARMLFVHPNTVRYRLRRVTDVTGWSPSDVRSAFTLRIALILGRLADADPQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JZU5</accession>
    <name>A0A2M9JZU5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">IclR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CG723_05045</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000002">
        <property type="protein sequence ID" value="PJN12413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN12413">
        <property type="protein sequence ID" value="PJN12413"/>
        <property type="gene ID" value="CG723_05045"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014757">
        <property type="entry name" value="Tscrpt_reg_IclR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005471">
        <property type="entry name" value="Tscrpt_reg_IclR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09339">
        <property type="entry name" value="HTH_IclR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01614">
        <property type="entry name" value="IclR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00346">
        <property type="entry name" value="HTH_ICLR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51077">
        <property type="entry name" value="HTH_ICLR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51078">
        <property type="entry name" value="ICLR_ED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH iclR-type" evidence="3">
        <location>
            <begin position="15"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="domain" description="IclR-ED" evidence="4">
        <location>
            <begin position="78"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PJN12413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="273" mass="30285" checksum="E6FB6CCFD566C3B9" modified="2018-04-25" version="1">MSEIPLDRKTPAGALQTVDRALLVLLAFERTRPDWGVTEVAAEFGWDTSVAQRLLSTLAGRGFLVSDPATRRYRIGPAVLRLGRLWERSGSLELLAAPVLEELGRVTGDTVLFCLPDSFHMRCVAAVEGESGPLRYYPLVGELYPAHAGATAKSFYAFLPDEQRHRLFRGRPMARFTDRTVTDPDELERELVQVRAQGYAWTVGEYDAGIATVAVPVFLGREPYGSLSLGGAKERFTDGPEGRLDALRKAARLLEKRLTHPPQRTRKPRAPQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K013</accession>
    <name>A0A2M9K013_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC transporter substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CG723_05145</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000002">
        <property type="protein sequence ID" value="PJN12430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN12430">
        <property type="protein sequence ID" value="PJN12430"/>
        <property type="gene ID" value="CG723_05145"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002491">
        <property type="entry name" value="ABC_transptr_periplasmic_BD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01497">
        <property type="entry name" value="Peripla_BP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50983">
        <property type="entry name" value="FE_B12_PBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014741148" evidence="3">
        <location>
            <begin position="33"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="domain" description="Fe/B12 periplasmic-binding" evidence="4">
        <location>
            <begin position="98"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="32"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="199"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="32"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PJN12430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="353" mass="36963" checksum="BB73A27C9263F156" modified="2018-04-25" version="1">MALRSSPRTRGTVAVALAVAAALSLAACGSGNSDSGSSAGSGKSDNGSGSKAVAQGGEDFAKAASQTAKMGTTAKAGQFPRTIEHAMGKTELKAQPKRVVVLDVGELDNVASLGVKPVGYAPTEGDDGVPSYLKKAAGTPKDVGTINSLNLEAIANLHPDLILGSELRAAKLYPQLSKIAPTVFSIRPGFTWKENYLLNASALDKTAEAKANLAAYEKKAEKLGEDIGEKKPTVTMLRYMPGMIRLYAKASFIGTILDDAGIPRPKNQQVVDLATEVSPEKIDQADADWIFTGVYGDAKKTDRATAEGNPLWKKLGAVQSGQAKDVPDETWYLGLGVTAANQVLGDLRGYLVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K085</accession>
    <name>A0A2M9K085_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">TetR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_05710</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000002">
        <property type="protein sequence ID" value="PJN12528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN12528">
        <property type="protein sequence ID" value="PJN12528"/>
        <property type="gene ID" value="CG723_05710"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023772">
        <property type="entry name" value="DNA-bd_HTH_TetR-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01081">
        <property type="entry name" value="HTH_TETR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="20"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="43"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN12528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="222" mass="23273" checksum="D9877EBD6B534508" modified="2018-04-25" version="1">MSPTKDQRSPQPSLTERRKAATQLDIARAAAGLFAEHGPDGTTAEDIAQRAGVALRTFYRYFRGKQDAVGPLLAAGGDAWRALLEDAEPGTDLRVTLETAVTATLSAPGDHGPEQLETTRGLLRAAQDDAALRAVWYRVNQESEERLVPVLTRLAGEEADPLDVRLAAAAATDAIRIALEAWAATDAPATGATGSPAVLALRCLRELTGGISLLGAGRGGAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K0G8</accession>
    <name>A0A2M9K0G8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_06115</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000002">
        <property type="protein sequence ID" value="PJN12604.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN12604">
        <property type="protein sequence ID" value="PJN12604"/>
        <property type="gene ID" value="CG723_06115"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016156">
        <property type="entry name" value="FAD/NAD-linked_Rdtase_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028202">
        <property type="entry name" value="Reductase_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14759">
        <property type="entry name" value="Reductase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55424">
        <property type="entry name" value="SSF55424"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyr_redox_2" evidence="1">
        <location>
            <begin position="17"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="domain" description="Reductase_C" evidence="2">
        <location>
            <begin position="326"/>
            <end position="409"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN12604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="411" mass="43344" checksum="2EF3EE9A7BD62958" modified="2018-04-25" version="1">MSEQTQNQAPVPQAGRHVVIVGAGMAGVQTAVALREQGFTGAVTLIGAEPHQPYDRPPLSKAVLLGKAEGSAFDVDFEALDITLELGREVTGVRPAEHTLDTATGPAPYDVLVLATGAEPIRLPGTEDIPGVHLLRTLDDAERLRPVLAAQRDIVVVGAGWIGAEFATAAREAGCAVTVVEAAERPLAGALPEEVAAPMAAWYADAGAELRTHARVEHVEAGSVVLDDGTRVPAGAVVVGIGARPATGWLTGSGITLGAHREVMADNRLRTSEPDVYAVGDCSSFPSGRYGERLMVHHWDNALQGPRTVAANIIGENPATYDPVPYFWSEQFGRFVQYAGHHAAADATVWRGDPQGASWSVCWLRESRLVGVLAVGRPRDLAQGRKLIESGAPLDPQAIRDPARPLKAAVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-09-29" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K0V0</accession>
    <name>A0A2M9K0V0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_06975</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000002">
        <property type="protein sequence ID" value="PJN12748.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN12748">
        <property type="protein sequence ID" value="PJN12748"/>
        <property type="gene ID" value="CG723_06975"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043917">
        <property type="entry name" value="DUF5753"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19054">
        <property type="entry name" value="DUF5753"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="24"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN12748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="276" mass="30722" checksum="A8CA6D7211FB4795" modified="2018-04-25" version="1">MEGQQVEGEHEFGAGILHVFGRQVKLCRERAGLDRADLGARTGYSASTIASFEQGRRIPPPKFIDLADEVLDAGGVLRAGKEEVARAQYPAFFRDAAQHEAHAVESHVYAPQAAPGLLQTEEYARAVFAMWRPLLDEVLIEQRVAARLARQEIFARRPAPHMSFVIEEAVLHRPLGGEVVWRGQLEQFLLASEKRNVEIQVMPLSRLEHAGLAGPFTLMETRDGRRIAYTEVQGDSRVHTERGKVREIEAAYGSLRAQALTPAESLSLIEKLLGER</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-09-29" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K160</accession>
    <name>A0A2M9K160_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Cytochrome B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CG723_07300</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CB01635</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000002">
        <property type="protein sequence ID" value="PJN12810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN12810">
        <property type="protein sequence ID" value="PJN12810"/>
        <property type="gene ID" value="CG723_07300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016653">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H, heme protein as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006784">
        <property type="term" value="P:heme A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003780">
        <property type="entry name" value="COX15/CtaA_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02628">
        <property type="entry name" value="COX15-CtaA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0350">Heme biosynthesis</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="44"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="100"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="129"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="157"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="196"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="240"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="274"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="297"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PJN12810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="341" mass="36580" checksum="6EED96DFF8A1439F" modified="2018-04-25" version="1">MHKRRPTMGPVPNVTPADAARAVRNPLAFIAERWTPAQRTVRRAALSAVVMTVVIVVTGGAVRLTGSGLGCPTWPKCTDESLTATSAMGFHGAIEFGNRMLTYVLCAAVGWAIIAARSQKPWRRGLTRLGWAQFWLVMGNAVLGGIVVLVGLNPYTVAAHFLLSTALIAVATVMWQRTREGDAAPRPLVGKAVRQLVWILTAATVALIMVGTVVTGSGPHAGDSSDVERMPLDWETISKAHAVLAWIVVTLAFALWFVLKAVDAPKGPLHRTRDLFLVLLAQGVIGYVQYFTDLPEVLVGLHMLGSALVWIAVLRVLLSLRERPLGTAEVPAQADPALSTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K1I5</accession>
    <name>A0A2M9K1I5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Cobaltochelatase subunit CobN</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CG723_07720</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000002">
        <property type="protein sequence ID" value="PJN12887.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN12887">
        <property type="protein sequence ID" value="PJN12887"/>
        <property type="gene ID" value="CG723_07720"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051116">
        <property type="term" value="F:cobaltochelatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009236">
        <property type="term" value="P:cobalamin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd10150">
        <property type="entry name" value="CobN_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011953">
        <property type="entry name" value="Cobalto_CobN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003672">
        <property type="entry name" value="CobN/Mg_chltase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44119">
        <property type="entry name" value="PTHR44119"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02514">
        <property type="entry name" value="CobN-Mg_chel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02257">
        <property type="entry name" value="cobalto_cobN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PJN12887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="1231" mass="132358" checksum="B97688ECB2A62254" modified="2018-04-25" version="1">MSTVLLLSTADTDLLAARASGAPYRIGNPTRVDVQSELPELLDGVDIAVVRLLGGKRAWEDGLAALKASGVPTVLLGGESVPDAELMAESTVHAGAVAEALRYLVEGGPGNLVELARFLVQDVLRGGQGRAGSTQERHSAEPQKMPEYGVLGRRARVEGRPTVGVLFYRAHELSGNTAFVDTLCDAIEARGVNALPVYCGSLRGADPGLYELLGEADTLVATVLAAGGTHASQASAGGDEEAWDIGALADLDIPVLQGLCLTSSKAAWEASDAALSPMDAAMQVAIPEFDGRIVTVPFSFKEEGPDGVPVYAADPERAARVAGIAVRHARLGHKPNGEKKLAVVFTAYPTKHSRVGNAVGLDTPASAVRVLDALREAGYGVHGYPDNGDELIHRLIEAGGHDVEWLTEDQLASAPARVPLADYRAWFDKLAPELRDKMLEAWGEPPGSLYVDGDDIVLASLQFGNVVVMIQPPRGFGENPIAIYHDPDMPPSHHYMAAYRWLETVTSEGGFGADAVIHMGKHGTMEWLPGKGLGLSGSCAPDAVLGELPLIYPFIVNDPGEGTQAKRRGHATVVDHLVPPMARADTYGDLAKLEQLLDEYALVSDLDPTKAPAVRAQIWTLVKAAELHHDLHVDEQPDDGDFDEFVMHIDGYLCEIKDVQIRDGLHILGGGPVGEPRVNLVLAVLRASQVWGGTANALPGLRACLAEHFGLAEKELLGEPGAPVKVPAELTDLVSGPARSAADAIDLLEQLCRRSAEGMEERGWDAAAVPALVRDVVGTELPDAVAVLEFACRELVPRLARTTDEIGHILRALDGGYVPAGPSGSPTRGLVNVLPTGRNFYSVDPKAIPSRLSWEVGQALADSLVARYLADTGEYPKSVGLTVWGTSAMRTQGDDIAEILALLGCRPVWDDASRRVTGFEIVPAAELGRPRIDVTVRISGFFRDAFPHVVGLIDDAVQAVAALDETAEQNHVRAHVEQDTVEHGDRRRATARIFGSKPGAYGAGLLPLIDARNWQSDADLAEVYAVWGGYAYGRGLDGRAARGDMETAFRRINVAAKNVDTREHDLVDADDYFQYHGGMVAMVRHLTGASPEAYVGDSAVPDQVKTRTLGEETHRVFRARVVNPRWMAAMRRHGYKGAFEMAATVDYLFGYDATAGVVDDWMYEKLSAEYVFDAENQDFMKKSNPWALRGITERLLEAAERGLWAEPDAQTLERLRATYLELEGDLEGDDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K2P4</accession>
    <name>A0A2M9K2P4_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Chitosanase</fullName>
            <ecNumber evidence="1">3.2.1.132</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CG723_02185</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CB01635</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Aids in the defense against invading fungal pathogens by degrading their cell wall chitosan.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Endohydrolysis of beta-(1-&gt;4)-linkages between D-glucosamine residues in a partly acetylated chitosan.</text>
            <dbReference type="EC" id="3.2.1.132"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 46 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.132" evidence="1"/>
    <dbReference type="EMBL" id="NNBL01000001">
        <property type="protein sequence ID" value="PJN13405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN13405">
        <property type="protein sequence ID" value="PJN13405"/>
        <property type="gene ID" value="CG723_02185"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016977">
        <property type="term" value="F:chitosanase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00978">
        <property type="entry name" value="chitosanase_GH46"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.386.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000400">
        <property type="entry name" value="Glyco_hydro_46"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023099">
        <property type="entry name" value="Glyco_hydro_46_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023346">
        <property type="entry name" value="Lysozyme-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01374">
        <property type="entry name" value="Glyco_hydro_46"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036551">
        <property type="entry name" value="Chitosanase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53955">
        <property type="entry name" value="SSF53955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS60000">
        <property type="entry name" value="CHITOSANASE_46_80"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0964">Secreted</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014598683" description="Chitosanase" evidence="3">
        <location>
            <begin position="40"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="2">
        <location>
            <position position="59"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="2">
        <location>
            <position position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRNR" id="PIRNR036551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR036551-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PJN13405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="274" mass="29786" checksum="F74F23B1087DB1BF" modified="2018-04-25" version="1">MHTPHIRTSRRTLLALIGASVVAAPLLTTQLATATPVSASGLDDPAKKEIAMKLVSSAENSSLDWKAQYGYIEDIGDGRGYTAGIIGFCSGTGDMLDLVELYTQRKPGNVLAKYLPALREVDGTDSHDGLDPDYPGDWEKAAEDSAFQQAQNDERDRVYFNPAVSQGKADGIGTLGQFAYYDAIVMHGDGDDATSFRNIRKRALAQAQPPAQGGDEVAYLNAFLDARVWAMKQEEAHSDTSRVDTAQRVFLENGNLNLDPPLDWKVYGDSYHIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K2S4</accession>
    <name>A0A2M9K2S4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Sugar kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_02365</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ROK (NagC/XylR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000001">
        <property type="protein sequence ID" value="PJN13435.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN13435">
        <property type="protein sequence ID" value="PJN13435"/>
        <property type="gene ID" value="CG723_02365"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000600">
        <property type="entry name" value="ROK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18964">
        <property type="entry name" value="PTHR18964"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00480">
        <property type="entry name" value="ROK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN13435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="415" mass="42826" checksum="9E6CAF12C0B5ED06" modified="2018-04-25" version="1">MAGPRRRTVRDLRRNNRATVLRKLYFDGPLSRQELGPLTALSSGSISNVVSELVADGLLEEAGSVDSDGGRPRTLLRVAPHCGHLAGVDIGETRVRVELFDFTLNELARVDAPLPDGHHDARDVVRIVAAGLAQVLAEAKVAPDALIGVGIGVPGIVDASGAGGAVGAVVHGQAIGWDAVPLEAMLRDCGELPPELPLFVDNGAKTLGLAEMWFGAGRGARNAVVTLIGSGVGACVIADGVPYQGSSGSAGEWGHTTLQVGGRRCRCGARGCLEAYVGAEALLERWRESGGHPTSADEEGALAELLAAPEAAELLDETAEFLGAGIADLVNLFNPERIVVGGWAGLLLGSRLLEPVRRAAAAYALRHPYAQTTIELGRLGPDAVTVGAATLPLARFLAEGGASITSREPIVSGAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K2Y0</accession>
    <name>A0A2M9K2Y0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Peptide ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CG723_02590</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000001">
        <property type="protein sequence ID" value="PJN13473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN13473">
        <property type="protein sequence ID" value="PJN13473"/>
        <property type="gene ID" value="CG723_02590"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015833">
        <property type="term" value="P:peptide transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013563">
        <property type="entry name" value="Oligopep_ABC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08352">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01727">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="6">
        <location>
            <begin position="6"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="322"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="42"/>
            <end position="49"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PJN13473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="351" mass="37419" checksum="6B6E386F568BDAA4" modified="2018-04-25" version="1">MSTPVLQLDALERHFTASGGTVRAADGVTLTVGRGEVVGLVGESGSGKSTVGRCAVRLDEPTGGTVRINGTDVTTMSRRALRPLRKDFHLVFQDPSSSLDPRMTVGQIVAEPLRLHGIAKGEAARARVAELLAQVGLRPEHADRHPHELSGGQRQRISIARALSVDPELLVADEPTSALDVSVQASVLNLLADLQRDRGFGCLFITHDLAAVEYLADRIAVMYLGQIVEQAPTAELFADPKHPYTQALLSAAPVPDPVTQRTRERIVLSGELPSPLAPPPGCRFHTRCPLAVDRCRTEVPALRTLEGTDGGREVSCHLVADDGTAPDAAAPRTADTDESLRTIPHSRPASA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K362</accession>
    <name>A0A2M9K362_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Glycosyl hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CG723_03115</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000001">
        <property type="protein sequence ID" value="PJN13565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN13565">
        <property type="protein sequence ID" value="PJN13565"/>
        <property type="gene ID" value="CG723_03115"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006584">
        <property type="entry name" value="Cellulose-bd_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005084">
        <property type="entry name" value="CMB_fam6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012938">
        <property type="entry name" value="Glc/Sorbosone_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022409">
        <property type="entry name" value="PKD/Chitinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000601">
        <property type="entry name" value="PKD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035986">
        <property type="entry name" value="PKD_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011041">
        <property type="entry name" value="Quinoprot_gluc/sorb_DH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03422">
        <property type="entry name" value="CBM_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07995">
        <property type="entry name" value="GSDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00606">
        <property type="entry name" value="CBD_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00089">
        <property type="entry name" value="PKD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49299">
        <property type="entry name" value="SSF49299"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="SSF49785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50952">
        <property type="entry name" value="SSF50952"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51175">
        <property type="entry name" value="CBM6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50093">
        <property type="entry name" value="PKD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014689699" evidence="3">
        <location>
            <begin position="35"/>
            <end position="817"/>
        </location>
    </feature>
    <feature type="domain" description="PKD" evidence="4">
        <location>
            <begin position="497"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="domain" description="CBM6" evidence="5">
        <location>
            <begin position="689"/>
            <end position="815"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="204"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="204"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PJN13565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="817" mass="86533" checksum="40A054E9426F9BC9" modified="2018-04-25" version="1">MHRKRPRFRKALALLTGSLLAGASFAIGAPHAGAAPAPDAAAAAEDFQQVTLAKGAEEVGEPMSLAVLPDRKVLHTSRDGVLRLTDENGTTKVAGKLDVYSHDEEGLQGVGVDPKFSDNHFIYLYYAPPLDTPAGDAPNDGTAADFKPFDGHNQLSRFVLNADGTLDNASEKKILEIPTSRGICCHVGGDIDFDKDGNLYLSTGDDSNPFSSDGYTPIDEQPTRNPAYDARRSAGNSNDLRGKVLRIKVNDDATYSIPDGNLFAPGTDKTRPEIYAMGFRNPFRISVDKPTGIVYVGDYGPDAGTADPKRGPAGQVEFNRVTKAGNFGWPYCTGNNDAYIDYDFATKTSGAAFDCAAPKNTSPHNTGIVDLPPAQPAWIPYDGGSVPEFGTGSESPMGGPVYRYDAANTSPVKFPEAYDGNFFAGEFGRQWIKRIEQDADGKVAKINPFPWTGTQVMDMAFGPDGALYVLDYGLSWFGGDENSGLYRIENATDGHSPVVDAKVDKTSGQAPLKARFSSTASDADSDALTYSWNFGDGTTGTGAAPSHTYKKNGTYTATVTAKDTTGRTGSADAHIVVGNTAPKVTLELPADGQLFTFGDEVPFKVKVTDPEDGTIDCSKVKVTHVLGHDSHGHPITSANGCSGTLKTSADSEHDPNANIFGVFDAEYTDQGANGQPALTTHDQNVTQQKHRQAEHYGDSKGVSITAHTPAEGGKTVGDINNGDWISFKPYVLSNVKSFSASVASAGSGGTLEIRSGSATGRLLGSAKVEPTGSWETYKDVTGTISKAPAKTTTLFLVFKGAGTDALFDVDDFTFTTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JF35</accession>
    <name>A0A2M9JF35_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_45195</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000051">
        <property type="protein sequence ID" value="PJN05367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN05367">
        <property type="protein sequence ID" value="PJN05367"/>
        <property type="gene ID" value="CG723_45195"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="56"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="220"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN05367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="305" mass="32731" checksum="8763F2A324AEEC5F" modified="2018-04-25" version="1">MNAFLGGMATKLVDRWLTALVAPGLLWLVVLAAATRLEQSAPFRFGPLGDWLDRLSGIPALHTPAVVVLVAVAAMLAGGVVGQVASVLGGVVERCWAIPGALPPATWLLAARRRRWDRATRRLREAILRAAELDAQQTDAMALRRHRQRDRLGPGRALRPTRIGDRYARTAERVRCVNGLDDLALVWPRLWIVLPDPLRAEVAAARDSTSDAARLSGWGVLYLTISACWWPCALVGACLVVVSVLRARSTGENLAVLIETAVDLHSKDLTERLGLPPAESTVAAGHAITARLVGAPGSQDGTVTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JF84</accession>
    <name>A0A2M9JF84_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CG723_44220</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000046">
        <property type="protein sequence ID" value="PJN05550.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN05550">
        <property type="protein sequence ID" value="PJN05550"/>
        <property type="gene ID" value="CG723_44220"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PJN05550.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="80" mass="8985" checksum="00B72173A5986766" modified="2018-04-25" version="1">MRDVSGDREAVALDPDRPVKWVSVGEAHEMPRPEIVLGFHGLCLVKPVDDDDWYMGSLYDNGSIDCWTAYGDLYEALRGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JFA7</accession>
    <name>A0A2M9JFA7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Xylose isomerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_44045</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000045">
        <property type="protein sequence ID" value="PJN05576.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN05576">
        <property type="protein sequence ID" value="PJN05576"/>
        <property type="gene ID" value="CG723_44045"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036237">
        <property type="entry name" value="Xyl_isomerase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013022">
        <property type="entry name" value="Xyl_isomerase-like_TIM-brl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01261">
        <property type="entry name" value="AP_endonuc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51658">
        <property type="entry name" value="SSF51658"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AP_endonuc_2" evidence="1">
        <location>
            <begin position="20"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN05576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="271" mass="28829" checksum="FD55733260F2B8E2" modified="2018-04-25" version="1">MRVLVLTKPFGALPPEELAAQLAEAGADGTDLLVREGQTVTPQTSSRIGDAARALRRAGLELGLVSTDLATADRTADHVLGHCAEAGVPLVRVGFYRYDAEIGYAVGLDRARRDLAELAALAGRHGVRLVLALHHGTLHPSAAHALRLLADTEDLLVHPDPGNQAKEGSEDWRLTVDALGGTDRIGCVGVKNAVWEPGEAPGSWHCAWQPLADGGVVPWPTVLPGLTGLGYEGPLSLHVHYWTDDPFASVRRDLAYLRGLLLEPGTGQRGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JFM6</accession>
    <name>A0A2M9JFM6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CG723_44335</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000046">
        <property type="protein sequence ID" value="PJN05547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN05547">
        <property type="protein sequence ID" value="PJN05547"/>
        <property type="gene ID" value="CG723_44335"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PJN05547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="61" mass="7000" checksum="FC1BBBA0EA86FDAB" modified="2018-04-25" version="1">MRQLGLDPEEQKGTVTSINLDDDDHKTVIWSVDVVTKDWNKTDFEIDAVKGTITREEVDHD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JFR6</accession>
    <name>A0A2M9JFR6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_43185</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000042">
        <property type="protein sequence ID" value="PJN05736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN05736">
        <property type="protein sequence ID" value="PJN05736"/>
        <property type="gene ID" value="CG723_43185"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="209"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN05736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="233" mass="24921" checksum="B12BF6A84E92E899" modified="2018-04-25" version="1">MSDAAQPTAAEVRAAAEAVKAALDRHLAAVERRSGEDDPAVYEAFNELAAAAEEYDELLYDRYDEVTPFEIPGTEDSLPPYTGPEEPNALSVLIRRDYAVVEPQRLLAQAQRVADVEADSDLVDGAAAAVGTIGNSVHAALGVLFGEFEPDEIASRHKEFGLEEGDSTLWVTASDEPAEPGEWLDAPFDQADPQRVVCRFDVSSVFDDELDGDLADDGPGAVAGATEDELEPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JGS4</accession>
    <name>A0A2M9JGS4_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF4097 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_41545</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000036">
        <property type="protein sequence ID" value="PJN06078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN06078">
        <property type="protein sequence ID" value="PJN06078"/>
        <property type="gene ID" value="CG723_41545"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025164">
        <property type="entry name" value="DUF4097"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13349">
        <property type="entry name" value="DUF4097"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4097" evidence="1">
        <location>
            <begin position="20"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN06078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="220" mass="22604" checksum="95A1E6740FC08AF6" modified="2018-04-25" version="1">MQKFATTAPVTAVLDIPAGRVQLIAADRSDVTVEVRPANASKSRDVKAAERTTIAYDNGVLRVVNPEGDQHFGPSGSVEVTVQLPAGSGVEVKAKAAELRAVGRLGDLVFDGAYRHVKVDEAAGLRLTATDGDVEVKRLTGPGDISTARGDITVAEATGGKLTLTTQSGDITVTAAAGVSAALDAGTSHGRVTNSLKNDGSTTLDIRATTRQGDITARSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JGV2</accession>
    <name>A0A2M9JGV2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CG723_41515</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000036">
        <property type="protein sequence ID" value="PJN06072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN06072">
        <property type="protein sequence ID" value="PJN06072"/>
        <property type="gene ID" value="CG723_41515"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PJN06072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="233" mass="26081" checksum="0D706010DD1D34BA" modified="2018-04-25" version="1">MTNTDERTTLVREVRHRLAQEGPPWTRDHEGDFETVTLPERHCDQLRDLMVSEGVEKVVEVGLAYASSALAIGEALATINRPLPRHVIIDPFQEREYSNAGWDLLCSAGLDSIATLMLVPSSIALPQLLTEGFIADAAFVDGSHRFHEVFVDLYFLRKIVRPGGLIVIDDDWWPSVHTAVHYYERNLGWTVIPDAFPGEAIGVGPQGKQAARCKAFRLPDPSFEPSFEDFHAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JGY9</accession>
    <name>A0A2M9JGY9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CG723_41100</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000035">
        <property type="protein sequence ID" value="PJN06141.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN06141">
        <property type="protein sequence ID" value="PJN06141"/>
        <property type="gene ID" value="CG723_41100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025355">
        <property type="entry name" value="DUF4259"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14078">
        <property type="entry name" value="DUF4259"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PJN06141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="139" mass="14512" checksum="DDF0D38322778390" modified="2018-04-25" version="1">MGTWGTGPFASDLAADFVDELEGLTSQKVIKVLERAFQRVTDSGARVDGGDGTEAVAAAALVASTIPGSGIVIDPDDGPREPLPQLPLALRSSAVLALQCVLQDGSELLTGWVDNADAAQWRHEVQRIAEALGPIGHEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JGZ7</accession>
    <name>A0A2M9JGZ7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Sensor histidine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_40495</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000034">
        <property type="protein sequence ID" value="PJN06158.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN06158">
        <property type="protein sequence ID" value="PJN06158"/>
        <property type="gene ID" value="CG723_40495"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011712">
        <property type="entry name" value="Sig_transdc_His_kin_sub3_dim/P"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07730">
        <property type="entry name" value="HisKA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="85"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="138"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="domain" description="HisKA_3" evidence="2">
        <location>
            <begin position="197"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN06158.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="395" mass="42631" checksum="7F61014B4C0B9515" modified="2018-04-25" version="1">MLAMAQIRVVRRVLTESLAAMTFPILLLSILIAPVSAPVVAEIDRSRARWCGVKTMPLRPSTHSWAQWVVLQLRSRSIWRTDFPIFVAAVLLSVLSLVVTFFGFIGAVALVFSPVFWLFGIAAQVGPFTPKSVQETLLAMPAGVTLGAVTASVLTGISLLRDLVLRTFSRSRDQDLLAKLEELRTSRASLTAAFEFERQRIERDLHDGAQQELVAVVMRLGMLEATATATAAATDQERIVQLARQAQAHAERALERLRDTVRDIHPRELSDLGLIAAVRELAVRSPLRVELTSTGDDTQLSSPTATAVYFTVSEALTNIAKHAGVGSARIDMQCAATDVRVRVHDDGLGGARIDAGSGLAGLRERMRSVGGNLEILSPAGGGTEVVASAPSQPTW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-05-25" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JH85</accession>
    <name>A0A2M9JH85_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Deazaflavin-dependent nitroreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_40100</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>a quinol + H(+) + oxidized coenzyme F420-(gamma-L-Glu)(n) = a quinone + reduced coenzyme F420-(gamma-L-Glu)(n)</text>
            <dbReference type="Rhea" id="RHEA:39663"/>
            <dbReference type="Rhea" id="RHEA-COMP:12939"/>
            <dbReference type="Rhea" id="RHEA-COMP:14378"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
            <dbReference type="ChEBI" id="CHEBI:133980"/>
            <dbReference type="ChEBI" id="CHEBI:139511"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the F420H(2)-dependent quinone reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000033">
        <property type="protein sequence ID" value="PJN06225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN06225">
        <property type="protein sequence ID" value="PJN06225"/>
        <property type="gene ID" value="CG723_40100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004378">
        <property type="entry name" value="F420H2_quin_Rdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04075">
        <property type="entry name" value="F420H2_quin_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00026">
        <property type="entry name" value="hi_GC_TIGR00026"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00029371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN06225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="160" mass="17795" checksum="7BAD05F82612B627" modified="2018-04-25" version="1">MTANAQSGSPSSPSPYYLKGSRLNVRLNGVIGWLARHGVSLMGSAELSVRGRKSGQMQRIPVNPHTYKDAQYIVSARGHSQWVRNMRVAGAGELRVGRKVRTFTATEVPDNEKLPILRSYLEKWGWEVNQYFQGITAKSTDEELTAAAPDHPVFLITIEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-06-02" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JHX4</accession>
    <name>A0A2M9JHX4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">GntR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CG723_39535</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000031">
        <property type="protein sequence ID" value="PJN06357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN06357">
        <property type="protein sequence ID" value="PJN06357"/>
        <property type="gene ID" value="CG723_39535"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07377">
        <property type="entry name" value="WHTH_GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.530">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011711">
        <property type="entry name" value="GntR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008920">
        <property type="entry name" value="TF_FadR/GntR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07729">
        <property type="entry name" value="FCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
        <property type="entry name" value="GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00895">
        <property type="entry name" value="FCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00345">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48008">
        <property type="entry name" value="SSF48008"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50949">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH gntR-type" evidence="5">
        <location>
            <begin position="23"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="235"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="241"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PJN06357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="258" mass="28660" checksum="71B7D74E382DB407" modified="2018-04-25" version="1">MAAQRRETRQTRRTEAEAPRPRESVRARVHALLRARITSLALLPGAPLSENELAGELDVSRTPVREALILLGEESLVDVFPKLGTFVSRISVDAVLEAQFMREALELAALREAVKKSGAQDITALRAILDAQRAALKADDADAFFEQDEAFHRRLMEASGHRTLWRTVATAKAHLDRARRLSLPLPHRIETLVDEHTTVVDALERRDGARAEDALRGHLQGVFDDIGTIRASHPELFADPHEQPGAPPRPRVHPGLRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-05-25" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JI54</accession>
    <name>A0A2M9JI54_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Ribonuclease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CG723_38240</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000028">
        <property type="protein sequence ID" value="PJN06548.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN06548">
        <property type="protein sequence ID" value="PJN06548"/>
        <property type="gene ID" value="CG723_38240"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003714">
        <property type="entry name" value="PhoH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002716">
        <property type="entry name" value="PIN_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02562">
        <property type="entry name" value="PhoH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13638">
        <property type="entry name" value="PIN_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00670">
        <property type="entry name" value="PINc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="SSF88723"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-1277">Toxin-antitoxin system</keyword>
    <feature type="domain" description="PINc" evidence="6">
        <location>
            <begin position="12"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PJN06548.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="439" mass="47971" checksum="6F673B2E16477E56" modified="2018-04-25" version="1">MVTSNKRQPDRRTYVLDTSVLLADPNALTRFDEHEVVLPIVVVTELEAKRHHPELGYFARQALRLLDDFRIRHGRLDAPIPIGDLGGTLRVELNHSDPGVLPAGYRLGDNDSRILAVARNLQAEGYDVTVVSKDLPLRIKASSVGLLAEEYRAELAITDSGWTGMSELRLSGEQVDLLFEEESLYVPEAAELPVHTGLTIQSERGKALGRITAEGNVRLVRGDREAFGIKGRSAEQRIALDLLLDPDIGILSMGGRAGTGKSALALCAGLEAVLERRQHQKVMVFRPLYAVGGQELGYLPGTEAEKMGPWAQAVFDTLGSVAGKAVIEEVTARGMLEVLPLTHIRGRSLHDAFVIVDEAQSLERNVLLTVLSRIGANSRVVLTHDVAQRDNLRVGRYDGVVAVVEKLKGHPLFAHVTLTRSERSQIAALVTEMLEDGPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JIA1</accession>
    <name>A0A2M9JIA1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Enoyl-CoA hydratase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_38620</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the enoyl-CoA hydratase/isomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000028">
        <property type="protein sequence ID" value="PJN06611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN06611">
        <property type="protein sequence ID" value="PJN06611"/>
        <property type="gene ID" value="CG723_38620"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.12.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018376">
        <property type="entry name" value="Enoyl-CoA_hyd/isom_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014748">
        <property type="entry name" value="Enoyl-CoA_hydra_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00166">
        <property type="entry name" value="ENOYL_COA_HYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN06611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="263" mass="27331" checksum="021469C08BFBF17B" modified="2018-04-25" version="1">MSERFGEFVEVRRHGFVAELVLDRPKAMNAVSTAMAVSVGEACASLAGDGGARVVVLSSSAARAFCVGADLKERNSFSDAELLRQRPLTRGAYGGVLELPMPVIAAVHGFALGGGFELALACDLIVADETAVVGLPEVSVGVIPGGGGTQLLPRRVGAARAAELIFSARRVEAREALEIGLVDQVVGVGDDREAALELAGRIAANSPVGLRAAKRALRVGYGLDLRAGLEVEDAAWRSVAFSGDRAEGVAAFNEKRAPQWPGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JIM6</accession>
    <name>A0A2M9JIM6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_37205</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000026">
        <property type="protein sequence ID" value="PJN06724.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN06724">
        <property type="protein sequence ID" value="PJN06724"/>
        <property type="gene ID" value="CG723_37205"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="SSF88713"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014663949" evidence="2">
        <location>
            <begin position="36"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="24"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN06724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="415" mass="45375" checksum="CB2DC8624BB7CB64" modified="2018-04-25" version="1">MPDITRRGLIGLGAGAAAAAALAGCGTSNGQGGGAASVPLGDQGEGGAGKPDKPAARPIGDGSTSYTGKQPNQPGKPVPLEPGETPPQFVIFSWDGAGEVGNGLFPRFLDLAENHGAHMTFFLSGLYLLPESKKRLYRPPNNGVGASDIGYLTDAHIKETLKYVRRAWLEGHEIGTHFNGHFCAGTGTVANWTPAQWRSEIDQAKSFVKEWRTNTGWHDLPSLPFDYEKELVGGRTPCLLGQDNLLPTARELGWRYDASSPGGRQRWPSKRGGVWDLPLQAVPFPGHTFEVLSMDYNMLANQSVNTTRAPAYNYPRWRKQSADAYIAGFDRAYETNRAPFFIGNHFEDWNGGIYMDSVEEALKHMAGQKDVRLVSFRQFVDWLDVQDPKVLDKLRSLDVGVRPDGGWKSYLKAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JJ68</accession>
    <name>A0A2M9JJ68_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Transcription-repair-coupling factor</fullName>
            <shortName evidence="8">TRCF</shortName>
            <ecNumber evidence="8">3.6.4.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8 11" type="primary">mfd</name>
        <name evidence="11" type="ORF">CG723_36705</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CB01635</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">In the C-terminal section; belongs to the helicase family. RecG subfamily.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">In the N-terminal section; belongs to the UvrB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.-" evidence="8"/>
    <dbReference type="EMBL" id="NNBL01000025">
        <property type="protein sequence ID" value="PJN06827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN06827">
        <property type="protein sequence ID" value="PJN06827"/>
        <property type="gene ID" value="CG723_36705"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000716">
        <property type="term" value="P:transcription-coupled nucleotide-excision repair, DNA damage recognition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00969">
        <property type="entry name" value="TRCF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036101">
        <property type="entry name" value="CarD-like/TRCF_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003711">
        <property type="entry name" value="CarD-like/TRCF_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004576">
        <property type="entry name" value="Mfd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037235">
        <property type="entry name" value="TRCF-like_C_D7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005118">
        <property type="entry name" value="TRCF_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041471">
        <property type="entry name" value="UvrB_inter"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02559">
        <property type="entry name" value="CarD_CdnL_TRCF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03461">
        <property type="entry name" value="TRCF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17757">
        <property type="entry name" value="UvrB_inter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01058">
        <property type="entry name" value="CarD_TRCF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00982">
        <property type="entry name" value="TRCF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141259">
        <property type="entry name" value="SSF141259"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143517">
        <property type="entry name" value="SSF143517"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00580">
        <property type="entry name" value="mfd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 8" id="KW-0227">DNA damage</keyword>
    <keyword evidence="7 8" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6 8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0347">Helicase</keyword>
    <keyword evidence="3 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="9">
        <location>
            <begin position="641"/>
            <end position="802"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="10">
        <location>
            <begin position="827"/>
            <end position="977"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PJN06827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="1176" mass="128766" checksum="F635BA80C6EECF16" modified="2018-04-25" version="1">MSLHGLLDAVSRDPALAEAVKAATDGHRPHVDLVGPPAARPFAVAALARRTGRTVLAVTATGREAEDLAAALRSLLPPDGVVEYASWETLPHERLSPRSDTVGRRLAVLRRLAHPRTDDPETGPVSVVVAPVRSVLQPQVKGLGDLEPVALRTGQSADLNEIVEALAAAAYARVELVEKRGEFAVRGGILDVFPPTEEHPLRIEFWGDDVEEIRYFKVADQRSLEVAEHGLWAPPCRELLLTDQVRERAAALAEEHPELGELLGKIAEGIAVEGMESLAPVLVDDMELLLDVLPEGSMAVVCDPERVRTRAADLVATSQEFLQASWAATAGGGEAPIDVDAASLRSIADVRDRARELDMMWWSVSPFAADEELGSDTLKLGMHAPESYRGDTARALADTKGWLSDGWRTIYVTEAHGPAARTVEVLGGEGVPARLDQDLTELTPAVVQVSCGSIDYGFVDPALKLVVLTETDLTGQKAAGKDGQRMPARRRKTIDPLTLESGDYIVHEQHGVGRYIEMVQRTVQGATREYLVVEYAPAKRGQPGDRLYIPTDQLEQITKYVGGEAPTLHRLGGADWTKTKARAKKAVKEIAADLIKLYSARMAAPGHSFGPDTPWQRELEDAFPYVETPDQLTTIAEVKEDMEKTVPMDRLICGDVGYGKTEIAVRAAFKAVQDGKQVAVLVPTTLLVQQHFGTFSERYSQFPVNVRALSRFQTETESKATLEGLRDGAVDIVIGTHRLFSSETKFKDLGLVIVDEEQRFGVEHKEQLKKLRANVDVLTMSATPIPRTLEMAVTGIREMSTITTPPEERHPVLTFVGPYEEKQIGAAVRRELLREGQVFYIHNRVESIDRAAARLRDIIPEARIATAHGQMSEQALEQVVVDFWEKKFDVLVSTTIVESGIDISNANTLIVERGDNFGLSQLHQLRGRVGRGRERGYAYFLYPPEKPLTETAHERLATIAQHTEMGAGMYVAMKDLEIRGAGNLLGGEQSGHIAGVGFDLYIRMVGEAVADYRAAVEGGVEEEPPLDVKIELPVDAHVPHDYAPGERLRLQAYRAIASVNTEADVKAVREELTDRYGKLPEPVENLLLVAGLRMFARACGVGEIVLQGNNIRFAPVELRESQELRLKRLYPGTVIKAAAHQVLVPRPKTAKVGGKPLVGRELLGWVGEFLTSILGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JJ87</accession>
    <name>A0A2M9JJ87_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NIPSNAP family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_36110</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000024">
        <property type="protein sequence ID" value="PJN06929.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN06929">
        <property type="protein sequence ID" value="PJN06929"/>
        <property type="gene ID" value="CG723_36110"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012577">
        <property type="entry name" value="NIPSNAP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07978">
        <property type="entry name" value="NIPSNAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NIPSNAP" evidence="1">
        <location>
            <begin position="108"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN06929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="204" mass="22670" checksum="FDC1115FA99DD99C" modified="2018-04-25" version="1">MLYELATLSLDLYSVPKALSALEAYTTSDSTGGQLLGCWEPEHGIIVGQLLLLRGFENAEELSEERRRLLTSSDPFGIGQHLTAFQVESYAPFPFLPPVEPGRYGSVYEFRTYHLKVGGLVPTMAGWEAAVPERTRLYPLTTAMYGLDGVPRITHIWPFPDLNARLEIRRDSYERGIWPPQNGPENIAHATSTIALPTPISPLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JJI4</accession>
    <name>A0A2M9JJI4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Proteinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_35450</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000023">
        <property type="protein sequence ID" value="PJN07035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN07035">
        <property type="protein sequence ID" value="PJN07035"/>
        <property type="gene ID" value="CG723_35450"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014605226" evidence="1">
        <location>
            <begin position="29"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="domain" description="AB hydrolase-1" evidence="2">
        <location>
            <begin position="110"/>
            <end position="496"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN07035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="524" mass="55101" checksum="DC1B657CE2D89DC3" modified="2018-04-25" version="1">MYFRRHHSPVRGLRACGTLLAAAGLLMSACSPGSSGSTRTADVSLAALPRATPANLSAYYAQSLTWRECGVPGFECTTMKAPLDYEKPEAGDVKLAVARKKATGPGKRLGSLLVNPGGPGGSAIGYLQSYAALGYPAAVRARYDMVAVDPRGVARSEPVKCLDGKQMDAYTQTDVTPDDQAEKNELSAAFTKYAAGCETKSGKVLPHVSTVEAARDMDILRAALGDAKLNYVGASYGTFLGATYAGLYPERVGRLVLDGAMDPSLSAQDMNRDQTAGFETAFQSFAKDCVRRSDCPLGTGSVADAGKRLKAFFVDLDRTPIPTGDPSGRKLGEALATTGVIAAMYDEGQWAQLRSALSSAIKDKDGAGLLALSDSYYERDSDGTYANLMAANAAVNCLDLPPSFKSPDDLKSALPSFEKASPVFGDGLAWAALNCTYWPVKATGEAHRIEAKGAAPIVVVGTTRDPATPYRWAQALAGQLDSGTLLTYEGDGHTAYGRGSDCIDSAINAYLVDGTPPKDGKRCT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JJN2</accession>
    <name>A0A2M9JJN2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CG723_35715</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CB01635</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000023">
        <property type="protein sequence ID" value="PJN07080.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN07080">
        <property type="protein sequence ID" value="PJN07080"/>
        <property type="gene ID" value="CG723_35715"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="29"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="60"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="86"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="143"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="189"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="29"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="226"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="244"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PJN07080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="259" mass="27448" checksum="95238E1899E114B6" modified="2018-04-25" version="1">MSSPNCMVANEWVCGEYLRTRRQELVDAVVQHIGITAASVVIGVLIAFPLALLARRRRAFAGPVLGLTTVLYTIPSLAMFSLLLPLFGLSASLVITGLVLYTLTILVRNFLAGLQAVPDEAREAARGMGYGPARLLWEVELPLALPAILAGVRIATVSTVALTTVGAIVDYGGLGTLIMDGLDSDFKAQVLTASVLCVLLAVAADLLLLGIQRWLTPWTRVASGTSRIRRRTDRSGSPDRPGGGSGDAERRTEKAAQAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JJP4</accession>
    <name>A0A2M9JJP4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Galactonate dehydratase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_36565</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000024">
        <property type="protein sequence ID" value="PJN06997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN06997">
        <property type="protein sequence ID" value="PJN06997"/>
        <property type="gene ID" value="CG723_36565"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009063">
        <property type="term" value="P:cellular amino acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036849">
        <property type="entry name" value="Enolase-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029017">
        <property type="entry name" value="Enolase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029065">
        <property type="entry name" value="Enolase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018110">
        <property type="entry name" value="Mandel_Rmase/mucon_lact_enz_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013342">
        <property type="entry name" value="Mandelate_racemase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034593">
        <property type="entry name" value="Mandelate_racemase_DgoD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013341">
        <property type="entry name" value="Mandelate_racemase_N_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48080">
        <property type="entry name" value="PTHR48080"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13378">
        <property type="entry name" value="MR_MLE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02746">
        <property type="entry name" value="MR_MLE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00922">
        <property type="entry name" value="MR_MLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51604">
        <property type="entry name" value="SSF51604"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54826">
        <property type="entry name" value="SSF54826"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00908">
        <property type="entry name" value="MR_MLE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MR_MLE" evidence="1">
        <location>
            <begin position="125"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN06997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="381" mass="41239" checksum="11A722516012561D" modified="2018-04-25" version="1">MKIVRIETFQLPPRWLFCRIETDDGIVGWGEPVVEGRAEVVRTAVDTLAEYLVGQDPLHIQDHWQVLTKGGFYRGGPVLSSAVAGIDQALWDIAGQAYGAPVHALLGGPVRDSVRVYAWVGGDEPAQVAEEISAQIEHGFTAVKMNASGRVSPMPGPAEIEEVVQRVATAREVLGPGRDVAVDFHGRFTPAGARQVLDGIAPLRPLFAEEPLLPEHGHLLPRLVEGTSVPVATGERLYSRGEFLPVLQAGIAVAQPDLSHAGGISEVHRIASLADTFGVLLAPHCPLGPIALASSLQVAFATPNFLIQEQSRGIHYNRSADLLSYVLDPEPFRFTDGHAHRTTLPGLGVRVDEAAVRKADSSAHRWRNPVWRHDDGSFAEW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JK36</accession>
    <name>A0A2M9JK36_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">TetR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_35175</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000022">
        <property type="protein sequence ID" value="PJN07233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN07233">
        <property type="protein sequence ID" value="PJN07233"/>
        <property type="gene ID" value="CG723_35175"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041583">
        <property type="entry name" value="TetR_C_31"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17940">
        <property type="entry name" value="TetR_C_31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="13"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="36"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN07233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="204" mass="21994" checksum="057F85553E54466A" modified="2018-04-25" version="1">MSVRTSPTSAAGAPRAEVIADAALDLLAERGMRGLTHRAVDEAAGLPQGSTSNYARTRLALLEATVRRLAVRESRVLAVDELPDPADGIRSLVDGMALALHRYLTNHPQLLICRYELALEATRRPELRAFFDATGRQFHEPLTALLRAAGSQDPERHTLSLVAWSEGIMFSCVAGAFHASVPDLADLREGFGELLRGMLAASPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JKE9</accession>
    <name>A0A2M9JKE9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CG723_34415</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000021">
        <property type="protein sequence ID" value="PJN07346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN07346">
        <property type="protein sequence ID" value="PJN07346"/>
        <property type="gene ID" value="CG723_34415"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PJN07346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="374" mass="41426" checksum="B097F19A1C108BAB" modified="2018-04-25" version="1">MADDRPVALDEYPVHQVPLSMKHVATGDRNAYDRCIFHLVDPTGEYLLILGLGVYPNLGVIDAYATLRVGDSLHAVRASDALRDDARMELAVGPLRIHVERPLKDFVLTCAADPADPDGLSYEINWSAAFPALWEPHHTQRRGGRLTLEGRRFVQAGRCDGRLRVGGREVSLDGWTGTRDRSWGVRPVPGEEGGRLAEENRTEGFHWIWSPVRFDDRFLMVIVQEDADGYRTLNDATLVRDGHPDLQLGWPQADIAYRTGTRHPESAVVHLTDPLSRKPVELGVEILASSPLAVGAGYPPADDWQHGTWRGRDWTDRRSYDLSDPAAHPLAAYGVIDHAARFTLDGQVGHGIFEHGSFGRHDPSGFTGYDSVAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JKG5</accession>
    <name>A0A2M9JKG5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Allophanate hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CG723_34510</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000021">
        <property type="protein sequence ID" value="PJN07365.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN07365">
        <property type="protein sequence ID" value="PJN07365"/>
        <property type="gene ID" value="CG723_34510"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003778">
        <property type="entry name" value="CT_A_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02626">
        <property type="entry name" value="CT_A_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00797">
        <property type="entry name" value="AHS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="SSF50891"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00724">
        <property type="entry name" value="urea_amlyse_rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AHS2" evidence="4">
        <location>
            <begin position="27"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PJN07365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="289" mass="29346" checksum="55F05D8DFB48FAEE" modified="2018-04-25" version="1">MTDRAMAVVRAGALTTVQDEGRPGHAHLGVPHSGALDLPASRLANRLVGNPRGTAVLETTLNGCAVRPRCEVTVAVVGAPCTVTVDGRPVAWGAPVRVPAGALLDLGPALSGVRSYAAFAGGVAVEPVLGSRSTDLLSGLGPAPLADGAVLPLGTVASAHTRVDVAPQPGPPRELVLRISLGPRADWFTAASLRTLTTRAYRVSSASNRIGLRTEGPSLLRASEGELPSEGMVLGAVQVPPDGRPVVFLADHPTTGGYPVVAVVRQADLPAAAQATPGTPVRFVLAAGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JKP0</accession>
    <name>A0A2M9JKP0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">p-aminobenzoyl-glutamate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_33625</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000020">
        <property type="protein sequence ID" value="PJN07441.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN07441">
        <property type="protein sequence ID" value="PJN07441"/>
        <property type="gene ID" value="CG723_33625"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015558">
        <property type="term" value="F:secondary active p-aminobenzoyl-glutamate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902604">
        <property type="term" value="P:p-aminobenzoyl-glutamate transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004697">
        <property type="entry name" value="AbgT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30282">
        <property type="entry name" value="PTHR30282"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03806">
        <property type="entry name" value="ABG_transport"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="42"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="97"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="224"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="279"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="319"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="359"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="391"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="424"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="456"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="486"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN07441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="524" mass="54301" checksum="1E04BECFDA009906" modified="2018-04-25" version="1">MRSSAKELSASGQSTGGEEKPRGVDRVLSWIERAGNALPNPVVLFTALFAVVAVVSTALALADVSVTVPGTDDTQQITGLLTGEGVRWLVENLVTNFAAFPPIAAVLLMIMAVGVAEKAGLLETAMRATLARAPRAFLPYLVALVACQAHMMSDVAAIVLPPLAAVVFKSAGRHPAAGLIGGFACVTAGYAAGFTIGSLDALYTGITQQAVEVLPASHHVDVNILANYFFTATSSLVLGLLGGFLISRVLEPRLPAYESGDDGPADEDVHLTPAQRRGLLLSALAVVAYTAVVLSLWLPDGAPLRGDGGALVPSPLLTGIVPVLFGAFLLAGLVYGFTVKTLSGSDGVVTAMTDSVKNMAGYVVMMFVAAQVIAVFNWSNLGVLLAVKAAAFLQSIGLTGFGALVAFVLLVSCLNLVVLSGSALWSLIGPVFVPAFMLLGMNPALSQAAFRIGDSATAVITPMNPYVFLLLALLQRYEPEARLGTLISRLAIFVVPFLGVWLAILAVFYGFDLPLGPGAGIGLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JKP7</accession>
    <name>A0A2M9JKP7_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7">Ferredoxin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CG723_33685</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CB01635</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 7">Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>[3Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:21137"/>
        </cofactor>
        <text evidence="7">Binds 1 [3Fe-4S] cluster.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000020">
        <property type="protein sequence ID" value="PJN07451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN07451">
        <property type="protein sequence ID" value="PJN07451"/>
        <property type="gene ID" value="CG723_33685"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051538">
        <property type="term" value="F:3 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000813">
        <property type="entry name" value="7Fe_ferredoxin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00037">
        <property type="entry name" value="Fer4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00354">
        <property type="entry name" value="7FE8SFRDOXIN"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0003">3Fe-4S</keyword>
    <keyword evidence="7" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="7" id="KW-0249">Electron transport</keyword>
    <keyword evidence="5 7" id="KW-0408">Iron</keyword>
    <keyword evidence="6 7" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="4 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0813">Transport</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="9">
        <location>
            <begin position="31"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="70"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU365098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PJN07451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="106" mass="11360" checksum="11765A0BCC21B261" modified="2018-04-25" version="1">MAYVIGASCVDIMDRSCMEECPVDCIYEGERKLYINPAECIDCGACEVACPEQAITVDRKADPDFRADNRRFFDEPLPGRETPLGTPGGATGLGPVGVDTALVSGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JKV6</accession>
    <name>A0A2M9JKV6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_33920</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000020">
        <property type="protein sequence ID" value="PJN07488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN07488">
        <property type="protein sequence ID" value="PJN07488"/>
        <property type="gene ID" value="CG723_33920"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="42"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="236"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="265"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="318"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="399"/>
            <end position="418"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN07488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="432" mass="45733" checksum="007FC5F2EE5AE7C0" modified="2018-04-25" version="1">MTPDRDDRPPADTSDDMTALRARVAQLEAAAPARPRHHLRSFFAGLLIVLVAILTPLSAVATWASDIVGDTDRYVATMEPLASDPDVQAAVTNRVTNVVMENIDLKALLSDVAPADRPRLEKALGRLSGPLTSGLSGFVHNIVQKFVSSDSFEKLWTGLNRRVHTAVDKALTGSGGGAVKLTNDAVTIDLAPVIDEAKQRLVDRGLGVASKIPEVHTDFTVMTSDSIGKIKKGFRLLQLMGVWLPVITLVLAACAVLLAVRKRRALVAAGIAIAVGAAILGIGLWVFRAFYLDGLPSEVSQPAAGAVYDALVRFLRTTVRMLITVGIVVALAAWLSGDGRAATRVKAMWRGGIGAVRDAAGLTGGPVGAWVHRAKTWLNWTVVAVSAVIMLVWDRPTGVVIVWIALCALIALAVIEFLDDDGSPHVTAAPAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JKX7</accession>
    <name>A0A2M9JKX7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_33940</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000020">
        <property type="protein sequence ID" value="PJN07530.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN07530">
        <property type="protein sequence ID" value="PJN07530"/>
        <property type="gene ID" value="CG723_33940"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="145"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="178"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="206"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="233"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="294"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="324"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="348"/>
            <end position="364"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN07530.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="364" mass="38392" checksum="DF9B9096EE8B8D94" modified="2018-04-25" version="1">MRNPALRHVLTHLITPLLMCLGMGLAYMGAFVAPEPHHLPVAVVGAGPEAKVFAQTVKDKAGDALDVRTLDSRPAAVEQLQSRDIDGAYVLSAKSPELIVATAGSDMSAITAEKIFTPVATQQGVPLKVTDVTPTVSDDPTGQGLFFLLVALSIGSYASVAVIGAAGSALSMRTRAALVVGVSGVVGLVGAALAGPVFHLAHHGLWGMWAMSWLYSAGILFIGVGLHTFLKRWTTLALMVLFVMLNFTSSGGLYRPELQNGFFGTLHAFWNGAGFVEGSRSLLYFGSHDLARNVWTLAVWLVVGLALTGLAALTERRRGAVEVEPRQHVTHSVTQAPARSTAAAEEEAAAEEAAEEEMEETVAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JKY3</accession>
    <name>A0A2M9JKY3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Long-chain fatty acid--CoA ligase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_32690</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000019">
        <property type="protein sequence ID" value="PJN07534.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN07534">
        <property type="protein sequence ID" value="PJN07534"/>
        <property type="gene ID" value="CG723_32690"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-binding" evidence="1">
        <location>
            <begin position="35"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding_C" evidence="2">
        <location>
            <begin position="455"/>
            <end position="529"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN07534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="549" mass="59504" checksum="ECE6234F5630D7C1" modified="2018-04-25" version="1">MLSTMQDVPLLISRILTHGSTIHGTSQVTTWTGESGPQRRSFAEIGDRSAQLAHALRDNLGIVDDDRVATLMWNNAEHVEAYFAIPSMGAVLHTLNLRLPAEQLVWIVNHAADRVIIVNGSLLPLLAPLLPSLTGVEHIVVSGPGDRSLLDGARPQVHEYEELIAGKPVAYDWPQLDERQAAALCYTSGTTGDPKGVVYSHRSIYLHSMQVNMTQSMGLTDEDTSLVVVPQFHVNAWGLPHATFMTGVHMLMPDRFLQPAPLAEMIESERPTHAAAVPTIWQGLLAELTAKPRDVSSLGQVTIGGSACPPSLMKAFDELGMRVCHAWGMTETSPLGTVARPPAAAVGTDEEFAYRLTQGRFPAGVEARLSGPDGELLAWDGESAGELEVRGPWIAGAYYSGPDSEPLRPADKFSDDGWLKTGDVGTISPDGFLTLTDRAKDVIKSGGEWISSVDLENALMSHPDIAEAAVVAVPDEKWGERPLATVVLKDGASADFEILRAFLGEKVAKWQLPERWTVITAVPKTSVGKFDKKVLRKQYAEGELDITRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JL29</accession>
    <name>A0A2M9JL29_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CG723_32860</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CB01635</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000019">
        <property type="protein sequence ID" value="PJN07562.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN07562">
        <property type="protein sequence ID" value="PJN07562"/>
        <property type="gene ID" value="CG723_32860"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032688">
        <property type="entry name" value="ABC2_membrane_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12679">
        <property type="entry name" value="ABC2_membrane_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="57"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="89"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="139"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="175"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="205"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="239"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="275"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PJN07562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="301" mass="31955" checksum="CC7E4BB8F9DD352D" modified="2018-04-25" version="1">MAVEQSLTPAGEQTRIHNIGYRHYDGPRLGRAYARRSLFSQSLRGAYGLGRSAKSKVLPMLLFVVMCVPALIMVAVAVTTKMKDLPVDYTRYAILLQAVIGLYLASQAPQSVSRDLRFKTVPLYFSRPIERGDYVLAKFAAMTSALFALTAAPLIVLYVGALLAKLDFAEQTKGFAQGLVSVALLSLLFAGIGLVVSAVTPRRGFGIAAVIAVMTISYGAVSTVQAIADSQDNGGAITWLGLFSPVTLIDGVQTAFLGATSAFPGGHGPSTGQGVVYLLVVLGLIAGCYGLLMRRYRKVGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JLB8</accession>
    <name>A0A2M9JLB8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CG723_33270</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000019">
        <property type="protein sequence ID" value="PJN07669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN07669">
        <property type="protein sequence ID" value="PJN07669"/>
        <property type="gene ID" value="CG723_33270"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014955083" evidence="3">
        <location>
            <begin position="44"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="448"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="207"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="409"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="416"/>
            <end position="430"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PJN07669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="479" mass="49445" checksum="8CBF359D8E0A75FD" modified="2018-04-25" version="1">MSRRGGRRVVLRGRGRPVSAFTAGICAVAVPVAVVALPGTAAAGDSAPYVFAQGARTVQGAVTGTDAAELKAGEIYRSSIEAGVKGTGLGSGSGAKGAADTRYYRVDLDGSSDTYVSAVAVPKVGADVKVAFNDSISVTLQDRQGNRCDSEVAAFRSAEYPRPIAATAERVVREGGGRCQDAGTYYVVVARKTAPDSTRERWDLELSVSSEPALKSPPATTGPGAWPSASPRPPAGIPSERRGGTGFNDAQSLRQGVWKDRIRPGQTLFYRVPLDWGQQLFTEAELGTSAGDAHRTGFVPSALSVALYNPARTQITSKDASYGGEPSVAALDSLPPVAYENRYLSRADEAGVRFAGWYYLKVSLTPEMKGTFGNEESGLTLRLTVQGDAASAPAYVRDPGAFQVTDADRAAAESGSAQGGGSSLPSAGGQGGGQAAQGGSGRANRMTVVGIAGIGTGSVLVLGLGVWTYVARRRASAGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JLF6</accession>
    <name>A0A2M9JLF6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_32080</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000018">
        <property type="protein sequence ID" value="PJN07711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN07711">
        <property type="protein sequence ID" value="PJN07711"/>
        <property type="gene ID" value="CG723_32080"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="32"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN07711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="68" mass="7223" checksum="87DEB8CCE45CFD7C" modified="2018-04-25" version="1">MADTAPRTMVRTQGRRAFAAFGGRRSERRHPLVAAAMVLPLAALLVVVFGGWEAVVTQASSVGVMLGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-06-02" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JLK5</accession>
    <name>A0A2M9JLK5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">NUDIX hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CG723_32305</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CB01635</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the Nudix hydrolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000018">
        <property type="protein sequence ID" value="PJN07754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN07754">
        <property type="protein sequence ID" value="PJN07754"/>
        <property type="gene ID" value="CG723_32305"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020476">
        <property type="entry name" value="Nudix_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020084">
        <property type="entry name" value="NUDIX_hydrolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00502">
        <property type="entry name" value="NUDIXFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="SSF55811"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00893">
        <property type="entry name" value="NUDIX_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="4">
        <location>
            <begin position="38"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003476"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PJN07754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="184" mass="21094" checksum="F4466F5D056BDDBC" modified="2018-04-25" version="1">MQWTKQNEQTVYENRWFRVNLADVELPDGRHLDHFVIRLRPVAVATVVNEANEVLLLWRHRFITDSWGWELPAGVVEDGEDIAAAAARELEEETGWRPGPLRHLMSVEPSNGLEDARHHVYWAEEGSYVGHPEDDFESDRREWVPLKLVPDMVARGEVPAANMAAALLMLHHLRLGQDAPGLRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JLX2</accession>
    <name>A0A2M9JLX2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Short-chain dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CG723_31245</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000017">
        <property type="protein sequence ID" value="PJN07874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN07874">
        <property type="protein sequence ID" value="PJN07874"/>
        <property type="gene ID" value="CG723_31245"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PJN07874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="235" mass="24839" checksum="38AEE7FC06215112" modified="2018-04-25" version="1">MNLRVLHPVRLAAEGAHVFITGRRKTELDVAVEAIGSAAATAVVGDISDLADLDHVYEAVRNRGQGLDVLFVNASVAEFATLEQVTEEHFDTHFRINVRGTLFTVQKALPLLNDGASVILNGSTNVDSGNETMGVYSATKGATRSFARTWANELKGRGIRVNAVTPGPIDTPGLSGLAPDEEQAAAFRQQLAAQVPLGRIGRPEEVAAAVAFLASEQSSFITGSSLYVDGGLNQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JM19</accession>
    <name>A0A2M9JM19_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">F420-dependent methylene-tetrahydromethanopterin reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CG723_31465</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CB01635</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the NtaA/SnaA/DszA monooxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000017">
        <property type="protein sequence ID" value="PJN07902.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN07902">
        <property type="protein sequence ID" value="PJN07902"/>
        <property type="gene ID" value="CG723_31465"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01095">
        <property type="entry name" value="Nitrilotriacetate_monoxgenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011251">
        <property type="entry name" value="Luciferase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036661">
        <property type="entry name" value="Luciferase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016215">
        <property type="entry name" value="NTA_MOA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00296">
        <property type="entry name" value="Bac_luciferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000337">
        <property type="entry name" value="NTA_MOA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51679">
        <property type="entry name" value="SSF51679"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03860">
        <property type="entry name" value="FMN_nitrolo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="2" id="KW-0288">FMN</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bac_luciferase" evidence="3">
        <location>
            <begin position="26"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="97"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="219"/>
            <end position="222"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00033748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000337-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PJN07902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="457" mass="50695" checksum="E8FDE5148D9961FB" modified="2018-04-25" version="1">MSKPLKQIHLAAHFPGVNNTTVWSDPEAGSHIEFSSFAHFARTAERAKFDFLFLAEGLRLREQGGKIYDLDVVGRPDTFTILTALAAVTEHLGLTGTINSTFNEPYEVARQFASLDHLSGGRAAWNVVTSWDAFTGENFRRGGYLPQEERYSRAKEFLTTAHELFDSWHGDEIVADQTTGAFLSDAKAGAFVHQGQHFDIEGQFNVPRSPQGRPVIFQAGDSEEGREFAAAGADAIFSRYATLKEGQAFYTDVKNRLARYGRRAEQLLILPAASFVLGDTDEEAEEIAKEVRRRQVSGATAIKHLEFVWNRDLSSYDPDGPLPDVDPDLGEHTIARGRAQVRMYRDPLATAREWRELATANNWSIRDLVIETGNRQNFVGSPATVARTINDYVQADVSDGFILAPHITPTGLDAFADQVVPLLQERGVYRAEYEGTTLRDHLGLAHPDQVRDEGAAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JM37</accession>
    <name>A0A2M9JM37_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CG723_31615</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000017">
        <property type="protein sequence ID" value="PJN07925.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN07925">
        <property type="protein sequence ID" value="PJN07925"/>
        <property type="gene ID" value="CG723_31615"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015833">
        <property type="term" value="P:peptide transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013563">
        <property type="entry name" value="Oligopep_ABC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08352">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="13"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="290"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="45"/>
            <end position="52"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="322"/>
            <end position="329"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PJN07925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="548" mass="58933" checksum="0184EFDA3A8C1721" modified="2018-04-25" version="1">MTTDPPENSDVLLSARNLTVGFGDRDVVRGISLTVRRGETVALVGESGSGKSVTARTLVGLTGAGARVAADELTWRGEDVRGWRERRWRRVRGRGIGFVLQDALVSLDPLRPVGKEIEDGLRLHGHGDRATRRARVLEVMAQVGIPDPELRAAQRPHELSGGLRQRALIAAALALDPPLLIADEPTTALDATVQAQILDLLAAARSRERGLLFITHDLGVVRRLADRVAVMRGGEIVEEGSVRDVLEDPQHSYTQGLLAADPALHPKGARLTPARTAAPAPNRRPHEVVLTADGLHKAYGGRDAVRDVSFALAAGRTLGIVGESGSGKSTTARIALGLTRPDTGTITLHGEPWSALPERERRPRRHGIQLVHQDPLSAFDPRWTVRRSLIDAVRLRRPGHPLSTPDEAARRVTELAAQVGLPDDTLDRHPLSLSGGQRQRAALARALAPNPAVLVLDEPVSALDVSVQAQVLDLLADLQDSLGLAYLFISHDLGVVRHVSDDVLVMKDGRVVESGLAEDLFAAPRHPYTRALLAAVHPHPTATTGATR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JM88</accession>
    <name>A0A2M9JM88_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">XRE family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_30295</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000016">
        <property type="protein sequence ID" value="PJN07991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN07991">
        <property type="protein sequence ID" value="PJN07991"/>
        <property type="gene ID" value="CG723_30295"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013096">
        <property type="entry name" value="Cupin_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07883">
        <property type="entry name" value="Cupin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01381">
        <property type="entry name" value="HTH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="2">
        <location>
            <begin position="16"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="180"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN07991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="203" mass="22157" checksum="52A3056495273DA7" modified="2018-04-25" version="1">MAQNDGELDSLVRKRIRALRVAQGWSLEELATRAGVSQSTLSRIENGQRRLALDQLVTLARALDTSLDQLVENASDDVITSPMIDAAHGTMRWPVKGDPGMSVVRQRMTEPPPDNPSRMRAHPGREWLVVLSGTAILMLGHRRFRVETNQAAEFPTMLPHAIGAEGGPCEILGIFDRDARRGHQRDSGSKGAGGDFEPGGRCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JME7</accession>
    <name>A0A2M9JME7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Proline-specific permease ProY</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">proY</name>
        <name evidence="10" type="ORF">CG723_30690</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CB01635</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the amino acid-polyamine-organocation (APC) superfamily. Amino acid transporter (AAT) (TC 2.A.3.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000016">
        <property type="protein sequence ID" value="PJN08051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08051">
        <property type="protein sequence ID" value="PJN08051"/>
        <property type="gene ID" value="CG723_30690"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006865">
        <property type="term" value="P:amino acid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004841">
        <property type="entry name" value="AA-permease/SLC12A_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004840">
        <property type="entry name" value="Amoino_acid_permease_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00324">
        <property type="entry name" value="AA_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00218">
        <property type="entry name" value="AMINO_ACID_PERMEASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="17"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="40"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="125"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="158"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="198"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="243"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="273"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="330"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="357"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="400"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="427"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="domain" description="AA_permease" evidence="9">
        <location>
            <begin position="16"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="464"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="467"/>
            <end position="487"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PJN08051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="487" mass="52218" checksum="10BC17C8BA2D7D9E" modified="2018-04-25" version="1">MSTDTTSLQRGLKSRHIRFIALGSAIGTGLFYGSSESIKAAGPAVLLAYLIGGAAVFLVLRSLGEMAVSRPCAGSFGEYATKYLGPLPGFLTGWTYALEMVFVCLADITALGVYMSFWFPDVPRWIWLLAAVGIIGAMNLFSVKVFGELEFWLSFAKVVAIIAMILAGLAIIVFGFGSNGGAGISNLWSNGGFMPNGIQGLVLCFAVVMFAFGGTEIIGVTAGEAQNPEKTIPSAVNSIPIRIVLFYVLTLAVLMSLNPWQHIGDKGSPFVEIFAGLGVASAAAVLNVVVIIAALSAINSNIFAAGRIMYGMAERNQAPSVMRRLSRNGVPWMTVVIMIGALLCGVVLNYLMPERVFLVIASIATFATVWVWLMILLSQVSARRKMSPQEVATLKYPAPFWPYGQIITIAFMVGVVVLLAFSDSTRIALLVGGVWLSLMTCVYYLWLRPRARRAALADAAPQVVHGEGKEPSDEIDSRAGAEPVHQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JMP3</accession>
    <name>A0A2M9JMP3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CG723_29440</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000015">
        <property type="protein sequence ID" value="PJN08132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08132">
        <property type="protein sequence ID" value="PJN08132"/>
        <property type="gene ID" value="CG723_29440"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PJN08132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="132" mass="14731" checksum="325D283E88C19FE2" modified="2018-04-25" version="1">MSRTVHHVPPPHRNDRSRNVSWWAIRSGPHASNSLTELRSSAAELTLARRMGRRPVPTLLVRSFAAYTYPRALGARVSAWRQPEAAARAGLRAFRTAAVKQLRAAGPGGLLVSAEDLDHPPTRHRHSTLWEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JMT9</accession>
    <name>A0A2M9JMT9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_29610</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000015">
        <property type="protein sequence ID" value="PJN08165.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08165">
        <property type="protein sequence ID" value="PJN08165"/>
        <property type="gene ID" value="CG723_29610"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="51"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN08165.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="95" mass="10487" checksum="DCD385A5158EB22D" modified="2018-04-25" version="1">MSLNDDLAAAERCLDELCRTVGRLERQLDGGLDVRRVRTDADHLRESVALLRATAASPPPPRRPELVPVPDTPYDSSLWTDSDDEGLGARDRHAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-06-02" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JMU3</accession>
    <name>A0A2M9JMU3_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Cytokinin riboside 5'-monophosphate phosphoribohydrolase</fullName>
            <ecNumber evidence="1">3.2.2.n1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_29760</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>9-ribosyl-trans-zeatin 5'-phosphate + H2O = D-ribose 5-phosphate + trans-zeatin</text>
            <dbReference type="Rhea" id="RHEA:48564"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16522"/>
            <dbReference type="ChEBI" id="CHEBI:78346"/>
            <dbReference type="ChEBI" id="CHEBI:87947"/>
            <dbReference type="EC" id="3.2.2.n1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>H2O + N(6)-(dimethylallyl)adenosine 5'-phosphate = D-ribose 5-phosphate + N(6)-dimethylallyladenine</text>
            <dbReference type="Rhea" id="RHEA:48560"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17660"/>
            <dbReference type="ChEBI" id="CHEBI:57526"/>
            <dbReference type="ChEBI" id="CHEBI:78346"/>
            <dbReference type="EC" id="3.2.2.n1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the LOG family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.2.n1" evidence="1"/>
    <dbReference type="EMBL" id="NNBL01000015">
        <property type="protein sequence ID" value="PJN08192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08192">
        <property type="protein sequence ID" value="PJN08192"/>
        <property type="gene ID" value="CG723_29760"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102682">
        <property type="term" value="F:N6-(Delta2-isopentenyl)-adenosine 5'-monophosphate phosphoribohydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009691">
        <property type="term" value="P:cytokinin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005269">
        <property type="entry name" value="LOG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031100">
        <property type="entry name" value="LOG_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03641">
        <property type="entry name" value="Lysine_decarbox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00730">
        <property type="entry name" value="TIGR00730"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0203">Cytokinin biosynthesis</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="22"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU363015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN08192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="249" mass="27139" checksum="38C3D2B61888E380" modified="2018-04-25" version="1">MSNPEGRKRPKEQRLGPVIRRHDQVQSSTTDQRLLDSEGPSEWVHTDPWRVLRIQSEFIEGFGTLAELPPAISVFGSARTQQDSPEYAAGVAIGRALVEAGFAVITGGGPGAMQAANQGAVEAKGISVGLGIELPFEQGLNQYVDLGLNFRYFFVRKTMFVKYAQGFVVLPGGLGTLDELFEALTLVQTTKVTRFPIVLFGTQYWSGLVDWLKNTVIAQGKASEADLLLFHVTDDVDEAIALVTKEVGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-09-29" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JN42</accession>
    <name>A0A2M9JN42_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Metallophosphoesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_28235</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000014">
        <property type="protein sequence ID" value="PJN08293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08293">
        <property type="protein sequence ID" value="PJN08293"/>
        <property type="gene ID" value="CG723_28235"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP_ApaH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="SSF56300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Metallophos" evidence="1">
        <location>
            <begin position="51"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN08293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="312" mass="33527" checksum="4D62DBD8BE0C3950" modified="2018-04-25" version="1">MRARYGVPLKVTAGITAAGAAGLIYAAGFEARSFRLRRVTVPVLPAGMRPLRVLQVSDIHMVGGQRKKQRWLRSLAGLRPDIVINTGDNLSDPEGVPEVLDALGPLMDFPGAYVFGSNDYYGPKPRNPVRYLFEKARGAHGLNGNAPAVGVVHNPWEDLRDGFDSAGWLNLTNTRGALKIEGMEIGFTGLDDPHIKRDRYAHVAGGPDSGADFSMGIVHAPYLRALDAFTADGYPLVLAGHTHGGQVCIPFYGALVTNCDLDTDRVKGLSTHESEGRRSYLHVSAGCGANRYTPVRFACPPEATLLTLTPGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JN94</accession>
    <name>A0A2M9JN94_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">SURF1-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CG723_28520</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CB01635</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the SURF1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000014">
        <property type="protein sequence ID" value="PJN08335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08335">
        <property type="protein sequence ID" value="PJN08335"/>
        <property type="gene ID" value="CG723_28520"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd06662">
        <property type="entry name" value="SURF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002994">
        <property type="entry name" value="Surf1/Shy1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045214">
        <property type="entry name" value="Surf1/Surf4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23427">
        <property type="entry name" value="PTHR23427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02104">
        <property type="entry name" value="SURF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50895">
        <property type="entry name" value="SURF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="217"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="43"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="254"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PJN08335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="275" mass="29003" checksum="B98EF35BDD461BEF" modified="2018-04-25" version="1">MYRFLLTPRWWGINLFVVLAIPFCVFMGSWQLGRFEDRVQGHKDASAQSTANEKAAPRPLDSLLPVDQKTSGKRATATGHYGKQFLVPDRELDGRTGFYVVTLLRTEGGAGRALPVVRGWVPGAASAAKAPAAPRGEVTVTGALQASESPGSGGAPAAGGLPAGQLGAISAASLVNLVPYDVYDAWVTLDRADSGMTAVPATAPQGSGLDLKAFQNLGYTGEWFVFAGFVVFMWFRLLRREAEFARDAALGLTESDDASDAADSPEPASPEAARG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JNI8</accession>
    <name>A0A2M9JNI8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_29090</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000014">
        <property type="protein sequence ID" value="PJN08431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08431">
        <property type="protein sequence ID" value="PJN08431"/>
        <property type="gene ID" value="CG723_29090"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13185">
        <property type="entry name" value="GAF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07228">
        <property type="entry name" value="SpoIIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00331">
        <property type="entry name" value="PP2C_SIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="SSF81606"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPM-type phosphatase" evidence="1">
        <location>
            <begin position="326"/>
            <end position="578"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN08431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="733" mass="78706" checksum="75A68C42EEB1E76B" modified="2018-04-25" version="1">MRTGDPLPPVGDVLAALDTGVWRWDNRAGLVTFDAEAARLLGLPECPVTLTEATVRSRFHPVDWNEIDGVVQLAVAEGTLAEARLRIMDDQGVVIRTVRSRSKPIMHGDSQAFELIGTLQEVSEPTPGSAALTPVTGDWRRSREAFLLDAGRALAEAGSTEEVLRVAAGLSMPGFSPDGLAVFGVGGDRLTVIGHHGHEPGEEGPFTDMPLDTDYPAAEVVRTGRAVYLSSPEQYRLRYQAAWPLAQRFHRQSWAFLPLIVAGRTIGTWMAAFTYPVSFTPDERSVLTTVARMLAQALSRAGITESERELTDGLQRSMLPTLGPDIPGMSVAARYVPTGGGLQVGGDWYDMIPLPTGRIALVIGDVQGHDVRAAGLMGQLRIALRAYASEGHRPDAVLSRASRFLYGVTDSITYGSTGGPGKGIEKGSEAGDPRFATCLYVEADPKTGTLEIARAGHPDPAIRMTDGTVLVRPTAGGLPLGVDPDADYPTTRLTLEPGDTLLICTDGLIETGGHDLDTGWARIRGILEEHGERPIDPDRLEDLADALVRAVHGPSSHYTTGPLADRREDDIAVLLLARTDLPEAPVPARRTAMTVAQAEPERVAAARQHLRELLHDWSDEDQVDSAVLMISEMLTNVLVHTDGDALLVAEVTGGPARRLRAEVADASDDLPHKRHPGELASSGRGLVLMELLAHRWGVDPRGEGKSIWFELYEPSADVSREPPDGAAGPSPAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JNV7</accession>
    <name>A0A2M9JNV7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MbtH family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_27655</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000013">
        <property type="protein sequence ID" value="PJN08556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08556">
        <property type="protein sequence ID" value="PJN08556"/>
        <property type="gene ID" value="CG723_27655"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005153">
        <property type="entry name" value="MbtH-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038020">
        <property type="entry name" value="MbtH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037407">
        <property type="entry name" value="MLP_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38444">
        <property type="entry name" value="PTHR38444"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03621">
        <property type="entry name" value="MbtH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00923">
        <property type="entry name" value="MbtH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160582">
        <property type="entry name" value="SSF160582"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MbtH" evidence="1">
        <location>
            <begin position="2"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN08556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="72" mass="8014" checksum="DEB91EA4B18DB460" modified="2018-04-25" version="1">MSDRDSADIAYAVVVNDEQQYSIWRADAELPPGWSAEGTTGAREVCLARIDEVWTDMRPLSLRRAMAQAGRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JP35</accession>
    <name>A0A2M9JP35_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HTH luxR-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_27660</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000013">
        <property type="protein sequence ID" value="PJN08557.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08557">
        <property type="protein sequence ID" value="PJN08557"/>
        <property type="gene ID" value="CG723_27660"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041664">
        <property type="entry name" value="AAA_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13191">
        <property type="entry name" value="AAA_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00622">
        <property type="entry name" value="HTH_LUXR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH luxR-type" evidence="2">
        <location>
            <begin position="701"/>
            <end position="766"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN08557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="774" mass="82328" checksum="89999B1895C11BBE" modified="2018-04-25" version="1">MEFSSRSSTSPTTGAPLLSVRSAGEIVPVLCPDGFEVGGGPRVVEVVADRWAGKSTVLDGLSAALAGRGWTVAAGAASPARSRAPFGVFVEALEDLVEHLDPDRLGGRGRDHAAQLAALFPALAPDAPRATSVDTYRICRAMRALLEMFAADGPLLLALDDVHWMDVDSLELLGQLLEQPVAGPVVIAVAHRGRPGDRVLNGLLARCASRGGCLRVRPAPLTEQEAIALLPDDLSRVHCETLLVESGGSPGLLRAFATLRQVPGLTGAWTPPLPADLLADVLRDFRALSPEGWQVVRAAAVLHEPYAADDLKEIAHVDDAALWRALDELIHEELLRPDELPWQLRFANPLLRVAAYQSAGRGWLLGAHAQAARILARPGYPSAHMARHLERGAALRDESGARVLWDAAARLLWQDPAQSVSWIRAALASRAGGDLEPRDRLLFGKALALAGRLTESLATLGPFGQGGVEAGLRVERVRWRAHAHRLLGHTDRAQDELESLLAELEPGEEGLGDVVRHALIELALHARRPVPPQPGGGEPGMPQGATGALRGRLLAQLAVAACRGGEQERAEQRALTARQLLDTAPDGEVAEQLEGLYWLATAEAALGRPSAACGHYERGLRIAETRRLTDHVPLFAMALSALQLHTGDGAGAARHAACAETVAAATESEHLRERALRLRRETASGAGVAVLPGQRQPADAAAVALEGLSRRESEVALLVSGGRTNQQIARVLELSHKTVETYLGRIFQKLQVQSRAEVAAMVGRSDRLGVAAGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JP59</accession>
    <name>A0A2M9JP59_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Cyclase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CG723_26515</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000012">
        <property type="protein sequence ID" value="PJN08654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08654">
        <property type="protein sequence ID" value="PJN08654"/>
        <property type="gene ID" value="CG723_26515"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004061">
        <property type="term" value="F:arylformamidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019441">
        <property type="term" value="P:tryptophan catabolic process to kynurenine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007325">
        <property type="entry name" value="KFase/CYL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037175">
        <property type="entry name" value="KFase_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04199">
        <property type="entry name" value="Cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102198">
        <property type="entry name" value="SSF102198"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PJN08654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="308" mass="33234" checksum="E25BAA364ECA10B4" modified="2018-04-25" version="1">MSLPAEFHEMAKRVNNWGRWGADDEIGTLNLVTDEVVREAASTIRTGRRVPLALPLKEDGVQTGLIPGRVNPFHTMVQINHELFGPGTVATSDDAVTMGLQAATHWDALTHISHSGRIYNGRPADTITAHGGARFSGIDKAPYIVSRGVLLDVAAAKGVDRLPGDHAVTPEDLSEAEEFGHVTVRAGDIVLVRTGQIQTYLAGDKHAYGYPSPGLSVRTPEWFHARDVAAVANDTLTFEIFPPEHENLWLPVHALDLVEMGMIQGQNWNLENLSTACGQDARYAFLLSAMPEPFVGGTGTPVAPVAIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JP65</accession>
    <name>A0A2M9JP65_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Acyl-CoA dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CG723_26525</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CB01635</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000012">
        <property type="protein sequence ID" value="PJN08656.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08656">
        <property type="protein sequence ID" value="PJN08656"/>
        <property type="gene ID" value="CG723_26525"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016627">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="SSF47203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="SSF56645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0274">FAD</keyword>
    <keyword evidence="3 5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA_dh_N" evidence="8">
        <location>
            <begin position="7"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_M" evidence="7">
        <location>
            <begin position="131"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_1" evidence="6">
        <location>
            <begin position="238"/>
            <end position="389"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PJN08656.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="399" mass="43915" checksum="E794095FD87D69F7" modified="2018-04-25" version="1">MEFGFGDEDEAFRREARAWLTEHLTGEYAVARGRGGPGSEHEDAGVRRAWELELGASGWIGLGWQRDGYGNRVASPTQQVVWAEEYARARAPARHGHIGENLLAPTLIAYGDEEQQRRFLPPIASGEELWCQGYSEPGAGSDLANLRTTAVRDGDTYRVTGQKVWTSLAHEADWCFVLARTEAGSRRHHGLSFLLVPMDQPGRIEVRPIRQLTGTAEFNEVFFDGAHAPVEHVVGGEGQGWRVAMGLLALERGVSTLAQQIGFAAELAEVVRTAVRTGAADDPLFRDRLVRQWAELRVMRFNALRTLGGAQDPGAPSVAKLLWGRWHQRLGELALQARGALAAAGPGDWAPDSTYELDAAQRLFLFSRADTIYGGSDEIQRNIIAERVLGLPRETRESS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JPN4</accession>
    <name>A0A2M9JPN4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Amino acid ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CG723_25355</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CB01635</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000011">
        <property type="protein sequence ID" value="PJN08831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08831">
        <property type="protein sequence ID" value="PJN08831"/>
        <property type="gene ID" value="CG723_25355"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="72"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="109"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="153"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="220"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="262"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="74"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PJN08831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="292" mass="32098" checksum="602133A88CA07F48" modified="2018-04-25" version="1">MKPGRGGVRRPLTRALPLAPSLVLLLLFLAGPIAYCAYIAFTDLQLTGQAHSSFVGFDNFTAAFRDDAFLNAVWLTLVFTVLSSLIGQNTLGLALAALMQRASKTVRTVTGAVVVCAWVLPEVVAGFLLYAFFRREGTLNAILDWLHLPTQNWLFTLPILAVSFANVWRGTAFSMLVYSAALAEIPKEITEAAEMDGAGGWRRMWHITLPMIRRSIGTNLMLNTLQTLSVFGLIWVMTRGGPGNRSQTLPLFMYEQAFQKSMIGYGTAVALLLLVVGSLFSLVYMRLLRSEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JPX2</accession>
    <name>A0A2M9JPX2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_25945</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000011">
        <property type="protein sequence ID" value="PJN08929.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08929">
        <property type="protein sequence ID" value="PJN08929"/>
        <property type="gene ID" value="CG723_25945"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN08929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="262" mass="28195" checksum="3A8F48A5791BE106" modified="2018-04-25" version="1">MRIELATEPGSPDRPNEDYASAAVPASGQGGALVVLDGVTPPRGETGCLHSVPWFTARLGGALGELSVSLRDMTLTAVLAEAIRRTADTHRRTCDLSHPRTPQATVVLARWDAERVEYLVLSDSVLLVEDASGSVTALVDDRLDRVPRSALVSDEVADATVRNKEGGFFTAAADPSAAARAVTGELPRAQARTLVALTDGVTRWVEKFREGDWADLFALVRKEGAHAAVARVRALEDADEQDRVFLRRSKTHDDATAVYVEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JQ10</accession>
    <name>A0A2M9JQ10_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">TetR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_26100</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000011">
        <property type="protein sequence ID" value="PJN08958.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08958">
        <property type="protein sequence ID" value="PJN08958"/>
        <property type="gene ID" value="CG723_26100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041583">
        <property type="entry name" value="TetR_C_31"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17940">
        <property type="entry name" value="TetR_C_31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="5"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="28"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN08958.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="196" mass="21295" checksum="BA9046D7C0DA0DB9" modified="2018-04-25" version="1">MARNAERRVALVNAAVEVLAAEGARGLTFRAVDAAAGVPTGTSSNYFTSRDDLLHQIDAWLHERLAPDPAVVAELLERPRDRELVAAFMHDLLGRAQRDRTGYLAMMEMRLEAGRRPELRASLMKSLRGDLDFGISFHAESGLPGGAETVTVLYLAVLGLILEHLTMPGMLDGAVPGVSVPEGLMDRIVRTIVPQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JQ43</accession>
    <name>A0A2M9JQ43_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">ARMT1-like_dom domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CG723_25815</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CB01635</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>beta-D-fructose 1-phosphate + H2O = D-fructose + phosphate</text>
            <dbReference type="Rhea" id="RHEA:35603"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:37721"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:138881"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>beta-D-fructose 6-phosphate = D-glyceraldehyde 3-phosphate + dihydroxyacetone</text>
            <dbReference type="Rhea" id="RHEA:28002"/>
            <dbReference type="ChEBI" id="CHEBI:16016"/>
            <dbReference type="ChEBI" id="CHEBI:57634"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the damage-control phosphatase family. Sugar phosphate phosphatase III subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000011">
        <property type="protein sequence ID" value="PJN08907.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08907">
        <property type="protein sequence ID" value="PJN08907"/>
        <property type="gene ID" value="CG723_25815"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036075">
        <property type="entry name" value="ARMT-1-like_metal-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039763">
        <property type="entry name" value="ARMT1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002791">
        <property type="entry name" value="ARMT1-like_metal-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12260">
        <property type="entry name" value="PTHR12260"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01937">
        <property type="entry name" value="ARMT1-like_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111321">
        <property type="entry name" value="SSF111321"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ARMT1-like_dom" evidence="5">
        <location>
            <begin position="21"/>
            <end position="371"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PJN08907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="396" mass="43961" checksum="7638FE938678F526" modified="2018-04-25" version="1">MENVDDVIRSNAPGSFPYSVLRERHPALIQRVRDAFPYDPERQRALDALLSESTDPAGVMEPLPADARDRDRWEEWGSGEHGGGSWFDAPFLWAESYFYRRLLDAVGYFDSAGPWQGIDPFRPFKQAELRSPEAQAELTALDRLAQEPPETQGRALLHGSLWGNRADLGFQLTATAPDAPTPTTPLLVDDSERLWSLLPPGAGNTVHVVADNAGRELVPDLLLIDHFLRHGHAEQVVLHVKPHPYYVSDATPTDVIDALRHLKRAPGEAGETGERLWHATSTGRLQLLAHPFSCAPLPYAAMPGDLRKCFEKATLTILKGDLNYRRLVGDQLRPPTTPFPTCTSYFPSPVAALRTLKSDVIVGLDKQTEDALNDSEPESWRTKGTHAVIQVRGEPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JQ54</accession>
    <name>A0A2M9JQ54_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">TetR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_25435</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000011">
        <property type="protein sequence ID" value="PJN09012.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN09012">
        <property type="protein sequence ID" value="PJN09012"/>
        <property type="gene ID" value="CG723_25435"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011075">
        <property type="entry name" value="TetR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16859">
        <property type="entry name" value="TetR_C_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="18"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="41"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN09012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="208" mass="22364" checksum="60D67C4CCCEA3B26" modified="2018-04-25" version="1">MQSRIPPPLPRTGRPRSATADAAILEATRAALVDLGWSKLTMGDVATRAGVAKTTLYRRWASKNELVVDAVAVLFDELELPDNGSLAADIGGVVLQFAALLNRPETKTALMAVVAESTRDEPLRERIRTSIVDRQKRLVLEGRARAHARGELPLEADPAAAARTADLIFDVVAGAVVHRTLVSAEPVDEEWVDRFTTLLLGGLASVQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JQ69</accession>
    <name>A0A2M9JQ69_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">AraC family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_26240</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000011">
        <property type="protein sequence ID" value="PJN08985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08985">
        <property type="protein sequence ID" value="PJN08985"/>
        <property type="gene ID" value="CG723_26240"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002818">
        <property type="entry name" value="DJ-1/PfpI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01965">
        <property type="entry name" value="DJ-1_PfpI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="1">
        <location>
            <begin position="215"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN08985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="320" mass="34720" checksum="8C536B77FA2BF052" modified="2018-04-25" version="1">MLKNVAAVLLDGVHPFELGVICEVFGLDRSEAGLPVYDFAAVSVEGPELATHVPGMTISTPFGLERLEEADLIAVPAAGTLRDGYPPELLDALRRAVDRGARVLSVCSGVFVLGAAGLLDGRRSAVHWRYADELAVRHPRTRVDPDVLYVDEGPVITSAGTAAGIDACLHIVRKEHGSEVANAIARRMVVPPHRDGGQAQYVKRPLPATPCDTVGGVLAWMEAHLDETLTVEELAARALMSPRTFARRFQQETGTTPYRWLLRQRVLLAQELLEQTDETVESIAGRAGFGNAAAMRHQFMKALGTTPNAFRRTFRVRSAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JQD6</accession>
    <name>A0A2M9JQD6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Phosphotransferase enzyme family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_24520</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000010">
        <property type="protein sequence ID" value="PJN09090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN09090">
        <property type="protein sequence ID" value="PJN09090"/>
        <property type="gene ID" value="CG723_24520"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="APH" evidence="1">
        <location>
            <begin position="32"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="domain" description="APH" evidence="1">
        <location>
            <begin position="367"/>
            <end position="601"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN09090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="691" mass="76649" checksum="D5E179CD2AE2B9F0" modified="2018-04-25" version="1">MARRLGQAPGTRVTVRVRKTEALPVVIRTWPDEKGILDAIGGVLPNVPQCLFKRADLAIHSYVEGVPLSSVCPNGKPVDSHLISALAGLLADMTRVSGRGLPPLPDFWPRRGRDSGAFLRALARAAEEQIRKPNWTAFGGLFAALGIAEDALTRFAERVPTLMRRPFSLLHGDLHRDNVIVSYHGDPPLICVDWELASYGDPLHDLATHLVRMDYPEEQWAEVTGGWREAMQCARSEATVGLGSDLRHYIDFEHAQSVYPDVMRAVTSLGDSFSQRDLDVAAQSVHRALRRAEKPLRLTRVPDVAKIEPILFRWREAQNGRYKGKPTISGISWTRDQRVPEHPEFPEHAVVQALLAEGGATADQVFKGTAHLSTVVRVPAVGFPVMVRRKAGSVSHTERRFLDEHAVLRAIEQSRGAVRAPRVLALGVSNLEDQFSIHSYEGPSRGLRPPEHPVDGLLPHEADDLVDQLCALTQVDTSVLDAPMGSQSFYAWLGHELVRLVDGLPKESRQLANKLGLPGARWLEWGLGRHVVSPRGRALLHGDLNPWNLVRREDGGLTLIDWEMAMVGDPLYDLVRHMHLTPTKSEIRQRMFARWTRQLPERFTNGWRADRHVYRSIEIVRSAYVDLDRLVTGAGLDAPNVLRAVGTYATTLHKALAWLGMPPGRTNPYLARALPSGDHGHPETAGVPTGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JQL3</accession>
    <name>A0A2M9JQL3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_24940</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000010">
        <property type="protein sequence ID" value="PJN09159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN09159">
        <property type="protein sequence ID" value="PJN09159"/>
        <property type="gene ID" value="CG723_24940"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021678">
        <property type="entry name" value="DUF3263"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11662">
        <property type="entry name" value="DUF3263"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN09159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="95" mass="10607" checksum="FC6908ED310E0BDA" modified="2018-04-25" version="1">MSEPPYAEPEPPAEDAEDAPPVGLSPREQGVLALERRGWASAGAKERAVREELGLAPVRYYQLLNALLDDPRALAHDPVTVNRLRRIREARRGER</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JQT0</accession>
    <name>A0A2M9JQT0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Acetyl-CoA carboxylase carboxyltransferase subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_25280</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000010">
        <property type="protein sequence ID" value="PJN09222.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN09222">
        <property type="protein sequence ID" value="PJN09222"/>
        <property type="gene ID" value="CG723_25280"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034733">
        <property type="entry name" value="AcCoA_carboxyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011763">
        <property type="entry name" value="COA_CT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011762">
        <property type="entry name" value="COA_CT_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045190">
        <property type="entry name" value="MCCB/AccD1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22855">
        <property type="entry name" value="PTHR22855"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01039">
        <property type="entry name" value="Carboxyl_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50989">
        <property type="entry name" value="COA_CT_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50980">
        <property type="entry name" value="COA_CT_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="CoA carboxyltransferase N-terminal" evidence="1">
        <location>
            <begin position="22"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="domain" description="CoA carboxyltransferase C-terminal" evidence="2">
        <location>
            <begin position="279"/>
            <end position="532"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN09222.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="532" mass="56730" checksum="5F0338E964B5C73C" modified="2018-04-25" version="1">MTVLASALDVGGADFAAHREAMIGKLDALDAEHAKALAGGGEKYVQRHRKRGKLLARERIELLLDPDTPFLELSPLAAWGSDYAVGASLVTGIGVVEGVECLVTANDPTVRGGASNPWSLKKALRANEIAFANRLPCISLVESGGADLPSQKEIFIPGGGIFRDITRLSAAGIPTVAVVFGNSTAGGAYIPGMSDHVIMVKERAKVFLGGPPLVKMATGEESDDESLGGAEMHARASGLADYFALDERDAIRQARRVVARLNHRKAYADPQLVEPPKYDSDELLGIVPGDLKVPFDPREVIARIVDGSDFDEFKPLYGSSLTTGWASLHGYPVGILANAQGVLFSEESQKAAQFIQLANQRDIPLLFLHNTTGYMVGKEYEQGGIIKHGSMMINAVSNSRVPHLSVLMGASYGAGHYGMCGRAFDPRFLFAWPSAKSAVMGPQQLAGVLSIVARQSAAAKGQPYDDEADAALRAMVEQQIESESLPMFLSGRLYDDGVIDPRDTRTVLGLCLSAIHTAPVEGARGGFGVFRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JRH6</accession>
    <name>A0A2M9JRH6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">3-hydroxyacyl-CoA dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_21990</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000008">
        <property type="protein sequence ID" value="PJN09452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN09452">
        <property type="protein sequence ID" value="PJN09452"/>
        <property type="gene ID" value="CG723_21990"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070403">
        <property type="term" value="F:NAD+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006176">
        <property type="entry name" value="3-OHacyl-CoA_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006108">
        <property type="entry name" value="3HC_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00725">
        <property type="entry name" value="3HCDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02737">
        <property type="entry name" value="3HCDH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="SSF48179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="3HCDH_N" evidence="2">
        <location>
            <begin position="10"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="domain" description="3HCDH" evidence="1">
        <location>
            <begin position="188"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN09452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="322" mass="34570" checksum="C5414AD42A6E78F8" modified="2018-04-25" version="1">MNEYKPVHRVAIVGTGTIGASWATHYLARGFDVTATDPAPAAEEALRSYVAAAWDAAATLGAEPGASPDRLRFTADMRQAVADADFVQENAPERPELKVKLFTDIDDATPPDSIIASSSSGITMSVIQAECRHPERTLIGHPFNPPHIMPLVEVVGGTKTAPETIRDAMSFYAAIGKKPIHLKKELPGHVANRIQAALYREVVHMIEQGVLDVADSDDAVSWGPGLRWGVMGPNLLWHLGGGEGGIRHFMDTLMPRMTGMWQELGTPELTPELKEKIVNGVLEEANGHSVDELASQRDAMLLNLLAVRAASGPHGDAASRSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JRM0</accession>
    <name>A0A2M9JRM0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glyoxalase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_22280</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000008">
        <property type="protein sequence ID" value="PJN09492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN09492">
        <property type="protein sequence ID" value="PJN09492"/>
        <property type="gene ID" value="CG723_22280"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004360">
        <property type="entry name" value="Glyas_Fos-R_dOase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00903">
        <property type="entry name" value="Glyoxalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VOC" evidence="2">
        <location>
            <begin position="61"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="30"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN09492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="181" mass="19565" checksum="E1080936BFBFE8AC" modified="2018-04-25" version="1">MGTHARTRPTGQAGSDVTRSCISPIPVARRSLDPTSIRGPPARRSSVAVTETTSTPSWPTCISAITLFVEDLDATKRFYREVFGLPVAFENDNSAVFEFGNTVINLLKTTAAPDLIEPARVAQADAGSRFQLTLPVDDVDAKCKELAARGVTLLNGPMDRPWGIRTASFRDPGGHIWEIAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JRM3</accession>
    <name>A0A2M9JRM3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NADH-quinone oxidoreductase subunit D</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CG723_22495</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CB01635</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000008">
        <property type="protein sequence ID" value="PJN09519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN09519">
        <property type="protein sequence ID" value="PJN09519"/>
        <property type="gene ID" value="CG723_22495"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042773">
        <property type="term" value="P:ATP synthesis coupled electron transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003918">
        <property type="entry name" value="NADH_UbQ_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001750">
        <property type="entry name" value="ND/Mrp_mem"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00361">
        <property type="entry name" value="Proton_antipo_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01437">
        <property type="entry name" value="NUOXDRDTASE4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="31"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="86"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="118"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="143"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="172"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="219"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="250"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="291"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="319"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="346"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="388"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="419"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="480"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="538"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="582"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="domain" description="Proton_antipo_M" evidence="3">
        <location>
            <begin position="138"/>
            <end position="429"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PJN09519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="603" mass="62538" checksum="6E0D5D5D3D1D2D01" modified="2018-04-25" version="1">MTAAQLLPLIVATPLLGAALLVAAGRRLPRFAAEVLGFVFSTGAAVWAVTLLVLSPSAGSRAVEWMGGWRPRDGVSVGIVLVGDRVGVGLAALTSVLVVAALAYSWRYFDEPPHQHAGSFPALILLFQAGMCGFTLTGDLFNAFVFFELMGVVAYALTGYRVEEARAVQGALTFGIINSLGGYTTLFGIVLLYARTGELGLAQIGGRLDTHPHDGRPDVLVLAAFVLVLTGLLVKAAAVPFHFWLPDAHAVAPTPVCILLSGVMVELGVYGTARVYWTAFAGPGGIPGPDVHRALLTLGVLTALVGAVMCWQQRHLKRLLAFSSVSHTGLFLIGVSVLSPEGLGGTVLYVLAHAGAKAALFACAGILLDRFSSVDEHELHGRARQLPLVGALFAAGGLALAGLPPFGTGLGKAVSEEAAGWWPTAVFVAASALTGGAVLRASARIFLGWGPRPSGNVETTTGKDEEPETRGPLRRIPDTMLAVPVALMAGALAVGVVPELWPAVGQAADAFTDHAGYTAAVLGTARTTPPPVSPAPHWTGVGVTLGLLSSALALALAWTAVRRPATDEPARWAAPLHRLQSGHLGDYVAFTLAGIALLTALLW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JRM7</accession>
    <name>A0A2M9JRM7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CG723_22570</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000008">
        <property type="protein sequence ID" value="PJN09531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN09531">
        <property type="protein sequence ID" value="PJN09531"/>
        <property type="gene ID" value="CG723_22570"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045383">
        <property type="entry name" value="DUF6528"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20138">
        <property type="entry name" value="DUF6528"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PJN09531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="315" mass="33967" checksum="6898EC4EA82E70CB" modified="2018-04-25" version="1">MRSAAAATDYLIVVVEQAANQIQRFSNGTTDWNGSPEWYWSAPSTDTWKYLADAKRRLTANWDDVLVCCANGTASTGGRAAMVRESDKAVVWTAVVPGNPHSVERIDGHGAIVTASAKQRATGDNYEAGGGINLFVPTSHGGLPPTSFADTISTGFPGAHGVLWDDANECLLAIGDNELRAYRLVTNSSGIITGLSQVSTLAFSGTGHDLQPDYASSDILYTVGGDAGNPDHGIWKTRLIYNNATGTWSFAAPARLYDWYFTKSFSRLPDGTEFWVDATSAATWWNDTVGFSGRADSVRSGAKFYKARFWSHVLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JRR0</accession>
    <name>A0A2M9JRR0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_22765</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000008">
        <property type="protein sequence ID" value="PJN09561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN09561">
        <property type="protein sequence ID" value="PJN09561"/>
        <property type="gene ID" value="CG723_22765"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014773743" evidence="1">
        <location>
            <begin position="28"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN09561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="249" mass="25602" checksum="C5F9E73E5FEF9573" modified="2018-04-25" version="1">MKRALTRIAVAALAALVPFIAAPGAQAQTFGGNELLSWTVSGAPSEGLTSLNFPITVNTGTAHVSGTYFAMQYGFTGQSDIGYAGLQPRPDANGHQRLRGVFSSFISGTTSTHANCSDGADGGAGVSCGVDFDAVYGHTFRVEIARVGTDTWSGTVVDTNNGQRIPVGTYKLPAGSGNLKASQAGFIEYYNVPSCDQQPRYDVTFGGPSSGSLSGTTKWVKEYGECAGYGSTQVTTVGAGVNVTRGSAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-09-29" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JRT3</accession>
    <name>A0A2M9JRT3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Type III polyketide synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CG723_22960</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CB01635</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the thiolase-like superfamily. Chalcone/stilbene synthases family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000008">
        <property type="protein sequence ID" value="PJN09595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN09595">
        <property type="protein sequence ID" value="PJN09595"/>
        <property type="gene ID" value="CG723_22960"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012328">
        <property type="entry name" value="Chalcone/stilbene_synt_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001099">
        <property type="entry name" value="Chalcone/stilbene_synt_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011141">
        <property type="entry name" value="Polyketide_synthase_type-III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11877">
        <property type="entry name" value="PTHR11877"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02797">
        <property type="entry name" value="Chal_sti_synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00195">
        <property type="entry name" value="Chal_sti_synt_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000451">
        <property type="entry name" value="PKS_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Chal_sti_synt_N" evidence="3">
        <location>
            <begin position="9"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="domain" description="Chal_sti_synt_C" evidence="4">
        <location>
            <begin position="213"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000451-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PJN09595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="350" mass="38185" checksum="B663C2F2744E4971" modified="2018-04-25" version="1">MAVLCKPAIAIPEHVITNEETLELARRLHHDHPQLDLALSLIENTGVQKRHLIQPIDVVLKHPGLDARSTIYERESKARVPQVVQRALDQAQLEPPDIDLIIYVSCTGFMMPSLTAWLINTMGFKPQTRQLPIAQLGCAAGGAAVNRAHDFCTAYPDANVLIVACEFCSLCYQPGDIGVGSLLSNGLFGDGIASVVVRGNGGTGMRLERNGSYLIPHTEDWISYAVRSTGFHFQLDKRVPKTMEPLSPALRALAEEHQWNVGKLDFYIVHAGGPRILDDLSRCLDIPPEAFRFSRATLTEYGNIASAVVLDALDRMFDEQSALEGHQGLIAGFGPGITAEIALGTWATDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-05-25" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JS90</accession>
    <name>A0A2M9JS90_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 13 15">tRNA (guanine-N(1)-)-methyltransferase</fullName>
            <ecNumber evidence="6 13 15">2.1.1.228</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">M1G-methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">tRNA [GM37] methyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="primary">trmD</name>
        <name evidence="18" type="ORF">CG723_21295</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">CB01635</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 13 15">Specifically methylates guanosine-37 in various tRNAs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 13 15">
            <text>guanosine(37) in tRNA + S-adenosyl-L-methionine = H(+) + N(1)-methylguanosine(37) in tRNA + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:36899"/>
            <dbReference type="Rhea" id="RHEA-COMP:10145"/>
            <dbReference type="Rhea" id="RHEA-COMP:10147"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:73542"/>
            <dbReference type="ChEBI" id="CHEBI:74269"/>
            <dbReference type="EC" id="2.1.1.228"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="5 13 15">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3 13 15">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 13 15">Belongs to the RNA methyltransferase TrmD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.228" evidence="6 13 15"/>
    <dbReference type="EMBL" id="NNBL01000007">
        <property type="protein sequence ID" value="PJN09740.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN09740">
        <property type="protein sequence ID" value="PJN09740"/>
        <property type="gene ID" value="CG723_21295"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052906">
        <property type="term" value="F:tRNA (guanine(37)-N(1))-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd18080">
        <property type="entry name" value="TrmD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1270.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1280.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00605">
        <property type="entry name" value="TrmD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029028">
        <property type="entry name" value="Alpha/beta_knot_MTases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002649">
        <property type="entry name" value="tRNA_m1G_MeTrfase_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023148">
        <property type="entry name" value="tRNA_m1G_MeTrfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029026">
        <property type="entry name" value="tRNA_m1G_MTases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016009">
        <property type="entry name" value="tRNA_MeTrfase_TRMD/TRM10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46417">
        <property type="entry name" value="PTHR46417"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01746">
        <property type="entry name" value="tRNA_m1G_MT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000386">
        <property type="entry name" value="tRNA_mtase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75217">
        <property type="entry name" value="SSF75217"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00088">
        <property type="entry name" value="trmD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 13 15" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 13 15" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11 13 14" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="10 13 15" id="KW-0808">Transferase</keyword>
    <keyword evidence="12 13 15" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="tRNA_m1G_MT" evidence="17">
        <location>
            <begin position="22"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="region of interest" description="S-adenosyl-L-methionine binding" evidence="13 14">
        <location>
            <begin position="140"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="254"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00014679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR000386-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU003464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF01746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="PJN09740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="273" mass="30336" checksum="3BE12CB324D01EAB" modified="2018-04-25" version="1">MRLDVVTIFPEYLDPLNVSLVGKARARGQLDVRVHDLREWTYDRHNTVDDTPYGGGPGMVMKTGPWGDALDDVLAEGYETGSHGPALVVPTPSGRPFTQELAVELSERPWLVFTPARYEGIDRRVIDEYATRMPVYEVSIGDYVLAGGEAAVLVVTEAVARLLPGVLGNAESHRDDSFAPGAMANLLEGPVYTKPPEWRGQGIPDVLLSGHHGKIARWRRDEALRRTTRNRPDLVERCDPSVFDKKDREMLSILGWRPGPDGRFGRDPEAVEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-09-29" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JSA6</accession>
    <name>A0A2M9JSA6_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ribosome-recycling factor</fullName>
            <shortName evidence="3">RRF</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Ribosome-releasing factor</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">frr</name>
        <name evidence="5" type="ORF">CG723_21380</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CB01635</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the RRF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000007">
        <property type="protein sequence ID" value="PJN09756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN09756">
        <property type="protein sequence ID" value="PJN09756"/>
        <property type="gene ID" value="CG723_21380"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006415">
        <property type="term" value="P:translational termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00520">
        <property type="entry name" value="RRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.132.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00040">
        <property type="entry name" value="RRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002661">
        <property type="entry name" value="Ribosome_recyc_fac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023584">
        <property type="entry name" value="Ribosome_recyc_fac_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036191">
        <property type="entry name" value="RRF_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20982">
        <property type="entry name" value="PTHR20982"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01765">
        <property type="entry name" value="RRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55194">
        <property type="entry name" value="SSF55194"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00496">
        <property type="entry name" value="frr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 3" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RRF" evidence="4">
        <location>
            <begin position="21"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PJN09756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="185" mass="20830" checksum="BFC1057137680E9A" modified="2018-04-25" version="1">MIEETLLEAEEKMEKAVVVAKEDFAAIRTGRAHPAMFNKIVADYYGALTPINQLASFSVPEPRMAVVTPFDKSALRNIEQAIRDSDLGVNPSNDGNIIRVTFPELTQDRRKEYIKVAKTKAEDSKISIRSIRRKAKETIDKLVKDGEVGEDEGRRAEKELDDTTAKYVAQVDELLKHKEAELLEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JSE2</accession>
    <name>A0A2M9JSE2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_21550</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000007">
        <property type="protein sequence ID" value="PJN09784.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN09784">
        <property type="protein sequence ID" value="PJN09784"/>
        <property type="gene ID" value="CG723_21550"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="26"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="90"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN09784.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="128" mass="14532" checksum="99FE20156AEA47D1" modified="2018-04-25" version="1">MRDERKYRNDLERRFRDNALKMRTRGFWLLVLSALLWLYVLARLLLPPGFLLASGDEHGAGCDDGLLFEEIRRSYDDGISNTCVLEPWPMIFAVLALSLPIGMAGAILYVRGVLSANLSHYIRSMTGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JSH9</accession>
    <name>A0A2M9JSH9_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 7 8">Translation initiation factor IF-2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">infB</name>
        <name evidence="11" type="ORF">CG723_21650</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CB01635</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7 8">One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7 8">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000007">
        <property type="protein sequence ID" value="PJN09802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN09802">
        <property type="protein sequence ID" value="PJN09802"/>
        <property type="gene ID" value="CG723_21650"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03702">
        <property type="entry name" value="IF2_mtIF2_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10050">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00100_B">
        <property type="entry name" value="IF_2_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044145">
        <property type="entry name" value="IF2_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006847">
        <property type="entry name" value="IF2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000178">
        <property type="entry name" value="TF_IF2_bacterial-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015760">
        <property type="entry name" value="TIF_IF2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023115">
        <property type="entry name" value="TIF_IF2_dom3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036925">
        <property type="entry name" value="TIF_IF2_dom3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43381">
        <property type="entry name" value="PTHR43381"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11987">
        <property type="entry name" value="IF-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04760">
        <property type="entry name" value="IF2_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="SSF50447"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52156">
        <property type="entry name" value="SSF52156"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00487">
        <property type="entry name" value="IF-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01176">
        <property type="entry name" value="IF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 7" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3 7 8" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="4 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 7 8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="10">
        <location>
            <begin position="530"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="49"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="69"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="109"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="539"/>
            <end position="546"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="589"/>
            <end position="593"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="643"/>
            <end position="646"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00020675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000644"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PJN09802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="1037" mass="105926" checksum="13C12CEA63316FF4" modified="2018-04-25" version="1">MAKVRVYELAKEFGVESKVVMAKLQELGEFVRSASSTIEAPVVRKLTDALQQGSGGGKPAARKAAPAKPSPARPSPAQAAKPAAPRPPAPKPAAAEKPAADAPVTPAAGQRPTPGPKPAPRPAAPAPAAPEFTAPPAAPAAPAAQAPAASPAAGPRPGARPGAPKPGGARPAGPGQGAQGQGRGERGDRGDRQGAPRPGGQGQGQRPGGRPAGPRPGNNPFTSGGSTGMARPQAPRPGGAPRPGGGQGGPGGPRPQGGPGGAPRPQGGQGGARPTPGGMPRPQAGAPRPGGAPGGNRPNPGMMPQRPAAGSPRPGGGPGGGRGPGGGGRPGGGGGGRPGGGGGFAGRPAGPGGGGGGFAGRPGGGGGGFAGRPGGGGGFAGRPGGGRPGGPGARGGTQGAFGRPGGPARRGRKSKRQRRQEYEAMQAPSVGGVMLPRGNGQSVRLSRGASLTDFAEKINANPASLVAVMMNLGEMVTATQSVSDETLKLLADEMNYILEIVSPEEEDRELLESFDIEFGEDEGGEEFLVARPPVVTVMGHVDHGKTRLLDTIRKTNVVAGEAGGITQHIGAYQVSTEVNEEERRITFIDTPGHEAFTAMRARGAKSTDIAILVVAANDGVMPQTIEALNHAKAAGVPIVVAVNKIDVEGADPTKVRGQLTEFGLVAEEYGGDTMFVDISAKQGLNIDSLLEAVVLTADASLDLRANPEQDAQGIAIESHLDRGRGAVSTVLVQRGTLRIGDTMVVGDAYGRVRAMLDDNGNNVEEAGPSTPVLVLGLTNVPGAGDNFLVVDEDRTARQIAEKRAARERNANFARRGVRFSLENLDEALKAGLVQELNLIIKGDASGSVEALESSLLQLDVGEEVDIRVLHRGVGAVTESDIDLATGSDAIVIGFNVRAAGRAAQMADREGVDVRYYSVIYQAIEEIEAALKGMLKPEYEEVELGTAEIREIFRSSKLGNIAGVLVRSGEVKRNTKARLLRDGKVIAENLNISGLRRFKDDVTEIREGFEGGINLGNFNDIKIDDVIATYEMREKPRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JSW9</accession>
    <name>A0A2M9JSW9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_19815</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000006">
        <property type="protein sequence ID" value="PJN09975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN09975">
        <property type="protein sequence ID" value="PJN09975"/>
        <property type="gene ID" value="CG723_19815"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043737">
        <property type="entry name" value="DUF5682"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18934">
        <property type="entry name" value="DUF5682"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="113"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="776"/>
            <end position="796"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN09975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="796" mass="84025" checksum="9852338C75B939AD" modified="2018-04-25" version="1">MSERGRGQGPLLLGVRHHGPGSARAVRAALDAAGPSVVLVEGPPEADALVALAADEGMVPPVALLAHVVDEPGRSAFWPLAEFSPEWVAIRWALERDVPVRFIDLPAAHSLALRDQGATPDDPEGDGGQGEGGEQGEEDSREAMRVDPLAVLAETAGHDDPERWWEDVIEHRGASGDAFAPFEALGEAMGALREEYGDGGHDRDLAREACMRLQLRTAQKEFGDGVAVVCGAWHVPALRTKTTVAADRAVLKGLPKAKVDMTWVPWTHRRLARAGGYGAGIDSPGWYGHLFSAPDRPVERWMTKVAGLFRDEDRIVSSAHVIEAVRLAETLAAMRGRPLAGLSETTDAVRAVMCEGSDVPLSLVHDRLVVGDVLGEVPDAAPAVPLQRDLTRLQRSLRLKPEALERELELDLRRETDAARSRLLHRLRLLDVGWGEPARSMRASTGTFRETWRLRWEPELSVRVAEAGVWGTTVLSAATARAEADAIGAPALADVTALAERCLLAELPDALPVVMRVLADRAAMDADVGHLAQALPALVRSLRYGDVRGTDTQALSEVAAGLAERVFVGLPPACAGLDGDAAAEMRGHVDAVHAAVGLLEDDGTAGPRGRWHSVLRVLAVRDSVAGVIRGRCARLLLDDGQLAEGEAARLMGLALSPGTGPAEAAAWIEGFVGGGSGGGLLLVHDERLLALVDDWLTGVSADAFTDVLPLLRRTFSAYESGVRRTLGELVRRGPSGAGPTAAVGTAPPGFAPGLDQVRADAVLPVLRLLLGTDDADAGSDSGTGSGRGDNDLVGVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JT35</accession>
    <name>A0A2M9JT35_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Transcriptional regulator WhiB</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">whiB</name>
        <name evidence="13" type="ORF">CG723_20010</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">CB01635</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Acts as a transcriptional regulator. Probably redox-responsive. The apo- but not holo-form probably binds DNA.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="11">Binds 1 [4Fe-4S] cluster per subunit. Following nitrosylation of the [4Fe-4S] cluster binds 1 [4Fe-8(NO)] cluster per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="11">The Fe-S cluster can be nitrosylated by nitric oxide (NO).</text>
    </comment>
    <comment type="PTM">
        <text evidence="11">Upon Fe-S cluster removal intramolecular disulfide bonds are formed.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the WhiB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000006">
        <property type="protein sequence ID" value="PJN10008.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN10008">
        <property type="protein sequence ID" value="PJN10008"/>
        <property type="gene ID" value="CG723_20010"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035731">
        <property type="term" value="F:dinitrosyl-iron complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01479">
        <property type="entry name" value="WhiB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034768">
        <property type="entry name" value="4FE4S_WBL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003482">
        <property type="entry name" value="Whib"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38839">
        <property type="entry name" value="PTHR38839"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02467">
        <property type="entry name" value="Whib"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51674">
        <property type="entry name" value="4FE4S_WBL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 11" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8 11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 11" id="KW-0408">Iron</keyword>
    <keyword evidence="6 11" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="4 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 11" id="KW-0804">Transcription</keyword>
    <keyword evidence="7 11" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="4Fe-4S Wbl-type" evidence="12">
        <location>
            <begin position="22"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="23"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="53"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="56"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="62"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51674"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PJN10008.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="112" mass="12091" checksum="8B73823F22FDB6E1" modified="2018-04-25" version="1">MADFSRLPGPNADLWDWQLLAACRGVDSSLFFHPEGERGAARSARENSAKEVCMRCPVRAECAAHALQVREPYGVWGGLTEDEREELMGRARNRLVAAAPASAGGAPPVVNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JT41</accession>
    <name>A0A2M9JT41_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 3">Methionine aminopeptidase</fullName>
            <shortName evidence="2">MAP</shortName>
            <shortName evidence="2">MetAP</shortName>
            <ecNumber evidence="2 3">3.4.11.18</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Peptidase M</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2 5" type="primary">map</name>
        <name evidence="5" type="ORF">CG723_20215</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CB01635</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 2">Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). Requires deformylation of the N(alpha)-formylated initiator methionine before it can be hydrolyzed.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 3">
            <text>Release of N-terminal amino acids, preferentially methionine, from peptides and arylamides.</text>
            <dbReference type="EC" id="3.4.11.18"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 3">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
        <cofactor evidence="2 3">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <cofactor evidence="2 3">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <cofactor evidence="2 3">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <text evidence="2 3">Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe(2+)-metalloproteases under physiological conditions, and the catalytically relevant metal-binding site has been assigned to the histidine-containing high-affinity site.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase M24A family. Methionine aminopeptidase type 1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.11.18" evidence="2 3"/>
    <dbReference type="EMBL" id="NNBL01000006">
        <property type="protein sequence ID" value="PJN10044.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN10044">
        <property type="protein sequence ID" value="PJN10044"/>
        <property type="gene ID" value="CG723_20215"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046914">
        <property type="term" value="F:transition metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070084">
        <property type="term" value="P:protein initiator methionine removal"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01086">
        <property type="entry name" value="MetAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01974">
        <property type="entry name" value="MetAP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036005">
        <property type="entry name" value="Creatinase/aminopeptidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000994">
        <property type="entry name" value="Pept_M24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001714">
        <property type="entry name" value="Pept_M24_MAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002467">
        <property type="entry name" value="Pept_M24A_MAP1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00557">
        <property type="entry name" value="Peptidase_M24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00599">
        <property type="entry name" value="MAPEPTIDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55920">
        <property type="entry name" value="SSF55920"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00500">
        <property type="entry name" value="met_pdase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00680">
        <property type="entry name" value="MAP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 5" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 3" id="KW-0645">Protease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase_M24" evidence="4">
        <location>
            <begin position="12"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="77"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="95"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="106"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="176"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="183"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="211"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002521"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PJN10044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="278" mass="29648" checksum="069DA2EF1F44ECCB" modified="2018-04-25" version="1">MVQIKTPEQIAKMREAGLVVAAIHAATREAAVPGAATRDLDEVARKVLDEHGAKSNFLGYGGFPATICTSVNEVVVHGIPDEKTVLKDGDIISIDCGAIIDGWHGDAAYTAFVGTGHAPELVELSRVTEESMWAGIAAMKNGNRLVDISRAIESYIRRQPKPGGGKYGIVEDYGGHGIGTEMHMDPHLLNYVERRRGKGPKLVPGFCLAIEPMVSLGTPRTEVLEDDWTVITTDGTWSSHWEHSIALTEQGPLVLTAPDGGKAKLAELGVTAAPDPLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-09-29" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JTU5</accession>
    <name>A0A2M9JTU5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CG723_18030</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CB01635</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000005">
        <property type="protein sequence ID" value="PJN10289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN10289">
        <property type="protein sequence ID" value="PJN10289"/>
        <property type="gene ID" value="CG723_18030"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="48"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="79"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="136"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="166"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="223"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="267"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="303"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="337"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="363"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="406"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="436"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="13"/>
            <end position="464"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PJN10289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="482" mass="48867" checksum="010D76047B096D59" modified="2018-04-25" version="1">MDAPQPTARAGGVVATLAFAGTTAAIMQTLVTPLIAELPKILHTTSSNAAWVITVTLLVGAVCVPVTGRLGDLVGKRRMLLACSVPLMAGSVVCALSSSVVPMIVGRGLQGMGMGMVPLGIALLRDVVAKEKLSSSIALVSASMGIGGGLGLPIAAAVAQYANWRVLFWGSAVLAVLIAALIWFLIPDVPASAKGQRFDAPGALGLGVGLVCLLLAVSKGAEWGWGSATTLVLFAAAVLVLLGWGWWETRTRDPLIDLRTTARPRVLFTNVASVFVGFGMYASMLVIPQLLQFPEATGYGLGQSMLAAGLWMAPGGIMMMIVSPLGGKLTDARGPKFTLICGVLVIAAGYGLSLVLMGSGLGLMVVCMVINSGVGLAYGSMPALIMSSVPLAETAAANGFNTLMRSLGTSVGAAVIGVILSQMTTTMGGYSFSSEAGFRTALMVGGGVALVAALIASVIPAVRATPVEAGTEPAAAPAEVKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JU19</accession>
    <name>A0A2M9JU19_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PG_binding_1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_18635</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000005">
        <property type="protein sequence ID" value="PJN10385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN10385">
        <property type="protein sequence ID" value="PJN10385"/>
        <property type="gene ID" value="CG723_18635"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.101.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002477">
        <property type="entry name" value="Peptidoglycan-bd-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036365">
        <property type="entry name" value="PGBD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036366">
        <property type="entry name" value="PGBDSf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01471">
        <property type="entry name" value="PG_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47090">
        <property type="entry name" value="SSF47090"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PG_binding_1" evidence="2">
        <location>
            <begin position="20"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN10385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="83" mass="8778" checksum="CBE49CC18BC7EA2E" modified="2018-04-25" version="1">MSSAAGPVSGARVLSTGSHGGQVKDLQRRLTQINLYTGPTDGRYSTDVADAVHRYQAARGIDEDAGVYGPETRAALESETRRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JUD2</accession>
    <name>A0A2M9JUD2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MBL fold metallo-hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_17575</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000005">
        <property type="protein sequence ID" value="PJN10479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN10479">
        <property type="protein sequence ID" value="PJN10479"/>
        <property type="gene ID" value="CG723_17575"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lactamase_B" evidence="1">
        <location>
            <begin position="83"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN10479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="281" mass="30760" checksum="831665D138A305B7" modified="2018-04-25" version="1">MSSSKKVAAVSGLRLPICCTCGVQYGAQRADCPVCLDERQYVGWEGQRWTSLGELRAGGRRGRLVEEGPGVIGVGAEPSVAVGQRALLIRSPHGNVLWDCVGYLDDELAAKIEDLGGVNAIAVSHPHFYGVMTEWGKVFDAPVYVHAADREWVGRPDPVIEYWTGDTHEIAPGMTLVNAGTHFAGGTVLHWADDPEGDGALFSGDIFMVVMDRRWVSFMYSIPNFIPERPSTIRRALALVEPFAFERIYGAFWGRVVSSDGAAAVRRSADRYLRFVRDDGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-05-25" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JVK3</accession>
    <name>A0A2M9JVK3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DNA-binding response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CG723_15925</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000004">
        <property type="protein sequence ID" value="PJN10931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN10931">
        <property type="protein sequence ID" value="PJN10931"/>
        <property type="gene ID" value="CG723_15925"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00383">
        <property type="entry name" value="trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="3">
        <location>
            <begin position="1"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="domain" description="OmpR/PhoB-type" evidence="4">
        <location>
            <begin position="126"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="2">
        <location>
            <begin position="126"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PJN10931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="232" mass="25671" checksum="72AAEF22FB3389F8" modified="2018-04-25" version="1">MLVVEDDQFVRSALIRHLAEASHTVRSVGTALEALREVAHFRFDVVILDLGLPDLDGSEALKMLRGITDVPVIIATARDDETEIVRLLNDGADDYLTKPFSPEHLSARMAAVLRRARSSAAAEPPSRLLQVGGLAIDPLRRQAELDGARLDLTRREFDLLTFLAGRPGVVVPRKELLAEVWQQSYGDDQTIDVHLSWLRRKLGETAARPRYLHTLRGVGVKLEPPRPEGGPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-09-29" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JW20</accession>
    <name>A0A2M9JW20_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Chitinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CG723_08895</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CB01635</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the glycosyl hydrolase 18 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN11080.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN11080">
        <property type="protein sequence ID" value="PJN11080"/>
        <property type="gene ID" value="CG723_08895"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033925">
        <property type="term" value="F:mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016289">
        <property type="entry name" value="Endo-Fsp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001223">
        <property type="entry name" value="Glyco_hydro18_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001579">
        <property type="entry name" value="Glyco_hydro_18_chit_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00704">
        <property type="entry name" value="Glyco_hydro_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001103">
        <property type="entry name" value="Endo-b-N-acetylglucosaminidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01095">
        <property type="entry name" value="GH18_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51910">
        <property type="entry name" value="GH18_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="1 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014922451" evidence="6">
        <location>
            <begin position="35"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="domain" description="GH18" evidence="7">
        <location>
            <begin position="45"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="3">
        <location>
            <position position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR001103-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PJN11080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="307" mass="32269" checksum="3DB1236E0CF2C9B8" modified="2018-04-25" version="1">MFTLVRSRARTAALALSAVAALAFGTATVTGAAAAPAPAPAKQGPTSVAYVEVNNNSMLNVGKYTLANGGGNVFDVAVIFAANINYDTGTKAAYLYFNDNVQRVLDNAATEIRPLQQKGIKVVLSVLGNHQGAGFANFPSQQAASAFAKQLSDTVTKYGLDGIDFDDEYAEYGNNGTGQPNDSSFVNLVTALRANMPDKIISLYNIGPAASRLSYGGVDVSSKFDYAWNPYYGSWQVPGIALPKSKLSPAAVEIGGTSQSTAADLARRTVSEGYGVYLTYNLDGADRTADVSAFTRELYGSDAVYTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JW70</accession>
    <name>A0A2M9JW70_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CG723_08855</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN11072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN11072">
        <property type="protein sequence ID" value="PJN11072"/>
        <property type="gene ID" value="CG723_08855"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016857">
        <property type="term" value="F:racemase and epimerase activity, acting on carbohydrates and derivatives"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008000">
        <property type="entry name" value="Rham/fucose_mutarotase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05336">
        <property type="entry name" value="rhaM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PJN11072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="107" mass="12574" checksum="DBCD767F8F5EFB3B" modified="2018-04-25" version="1">MKRMAQVIKVRPEKLAVYRELHRDVPQPVLDRLRRSQIANYSIHLLGDRLFSYFEYHGDDLEADLRAMADDEATQAWWALTDPCQEPVEEAAPGEWWTGLEQVFLME</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JWG7</accession>
    <name>A0A2M9JWG7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">NAD-dependent succinate-semialdehyde dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CG723_09955</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CB01635</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN11250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN11250">
        <property type="protein sequence ID" value="PJN11250"/>
        <property type="gene ID" value="CG723_09955"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016620">
        <property type="term" value="F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="SSF53720"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00687">
        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldedh" evidence="4">
        <location>
            <begin position="29"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PJN11250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="491" mass="51892" checksum="02D6FAFAB9E4B6D3" modified="2018-04-25" version="1">MTTTHPTPQVVEDVPKQLLIGGRLQDAAGGRTFSVDNPATGQSLCEVADAGPDDGRRAAEAATAAQESWAATAPRARSEILRRAYEIIIARTDELALLMTLEMGKPLAEARGEVTYAAEFFRWFSEEAVRIEGGFAPSPDGRSRHLIMRRPVGPCLLVTPWNFPLAMGTRKIGPAVAAGCTMVLKPAPQTPLCTLALAGILTEAGLPDGVLNVVTTTDAGALVEPLLRGGLIRKLSFTGSTQVGRILLAQCADTVVRTSMELGGNAPLIVFDDADLDTAVEGAMVAKMRNMGEACTAANRIFVHSSVADDFASRLAARMSALTVGPGTEPGTNVGPLIDAAGRDKVDRLVRDAVDRGAKVLTGGELPHGEGYFYPPTVLVRVPRDAGLTGTEIFGPVAALFTFEDEDEVVRAANDTEWGLVSYLFTRDLDRALRVGERLETGMVGLNTGLVSNPAAPFGGVKQSGIGREGGRVGIDEFLEYKYLAIPAPGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JWI2</accession>
    <name>A0A2M9JWI2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_09920</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN11243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN11243">
        <property type="protein sequence ID" value="PJN11243"/>
        <property type="gene ID" value="CG723_09920"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004104">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02894">
        <property type="entry name" value="GFO_IDH_MocA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GFO_IDH_MocA" evidence="1">
        <location>
            <begin position="37"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="domain" description="GFO_IDH_MocA_C" evidence="2">
        <location>
            <begin position="139"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN11243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="336" mass="35477" checksum="3542E211D479F37E" modified="2018-04-25" version="1">MKVGVLSFAHVHAGGFARLLDGMEGVEVLAADPDTDLAAPGEVRGREFADRLGVAYANSYEELFAWGPDKVVVCSENVRHRPLVELAAAHGVDVLCEKPLATTEEDGAAMVEACRAAGVRLAVAHPVRFSPAYTAVRAAVRSGTAGGVLAVSGANNGYLPAARRRWFADPRLAGGGALMDHTVHIADLLDDLFEASPATTVYAQVNNVLHEGQVDADTAGLITVEYANGAVATIDCSWSQPQHHPAWGGLQMQVIGDRATLEMDAFDQKVHGFSESSRAPFELPYGVNLDALMLHSFLYGSDGGTSVTDGESGLRSLRIVTAAYRSAAEGRAVPVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JWL6</accession>
    <name>A0A2M9JWL6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Short-chain dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_10145</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN11285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN11285">
        <property type="protein sequence ID" value="PJN11285"/>
        <property type="gene ID" value="CG723_10145"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="68"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN11285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="503" mass="54130" checksum="CC34050D94AA5902" modified="2018-04-25" version="1">MTMTEDSPTGATEAMVVSQESFGPGIDPERLAVCLSVLDELDKLDVDHPDAIQVRRATAGVYRTVKQRRRQERRAAKTAHDKAVTEATATGSAERIDDETEGLLPSSQVGEGKLAGILQRPRSCYTCKARYVEVDYFYHQLCPECAAVNRAKRDIRADLSGKRALLTGGRAKIGMYIALRLLRDGAHTTITTRFPKDAIRRFKAMDDSADWMDRLEVVGIDLRDPAQAVALAEQVAEQGPLDILINNATQTVRRLPSAYAALVEGESAPLPAGELPAHHVIGAFNSGAVDGLTALPAGISGLDAQKVADLALVAGNASVARHRDGSAIDAGGLVPDVVDSNTWVQTIEQISPVELLETQLCNYTAPFILISALRPAMADAAKKASSGRAYVVNVSAMEGVFGRGYKGAGHPNTNAAKAAMNMVTRTSAQEMFQTDGILMTSVDTGWITDERPHYDKLRLADEGFHAPLDLIDGAARVYDPVVRGEAGEDLYGVFMKDYAPGKW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JWV9</accession>
    <name>A0A2M9JWV9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CG723_10235</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CB01635</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN11302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN11302">
        <property type="protein sequence ID" value="PJN11302"/>
        <property type="gene ID" value="CG723_10235"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001851">
        <property type="entry name" value="ABC_transp_permease"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02653">
        <property type="entry name" value="BPD_transp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="34"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="60"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="88"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="120"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="149"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="187"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="237"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="268"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="293"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="318"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PJN11302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="344" mass="35268" checksum="AD2BC763704545DB" modified="2018-04-25" version="1">MADTKAPSALTTTKIGAPGKGPAKAVLLRRARELALVPALLLLMVLGAVVNDSFLTERNLISILGASAALAMVVLAESLVLITGKFDLSLESVVGIAPAVGALLVLPISQSGFGTEFPTVLALLAILVVGAAIGAFNGILVVKFKLNAFIVTLAMLIVLRGLLVGATKGKTLFGMPDAFFSLATTTFLRIPMSVWLAAIAFGVVGLILKYHRIGRALYAIGGNADAARAAGIRVERVMLGVFVIAGVLASVGGIMQTGYVGAISANQGNNMIFTVFAAAVIGGISLDGGKGTMFGALTGVLLLGVVQNLLTLAQVPSFWIQAIYGGIILLALMIARVTTGRAQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JX37</accession>
    <name>A0A2M9JX37_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">RNA polymerase sigma factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CG723_10315</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CB01635</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN11317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN11317">
        <property type="protein sequence ID" value="PJN11317"/>
        <property type="gene ID" value="CG723_10315"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039425">
        <property type="entry name" value="RNA_pol_sigma-70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000838">
        <property type="entry name" value="RNA_pol_sigma70_ECF_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007630">
        <property type="entry name" value="RNA_pol_sigma70_r4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43133">
        <property type="entry name" value="PTHR43133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04545">
        <property type="entry name" value="Sigma70_r4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01063">
        <property type="entry name" value="SIGMA70_ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0731">Sigma factor</keyword>
    <keyword evidence="5 6" id="KW-0804">Transcription</keyword>
    <keyword evidence="2 6" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="7">
        <location>
            <begin position="23"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4" evidence="8">
        <location>
            <begin position="123"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PJN11317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="184" mass="20267" checksum="AAE45BF5D9C25453" modified="2018-04-25" version="1">MTTATKTEGPDRTAAHVLAELQREHGRPLLSFLLRLCDGDRQRAEDLVQETFVRAWQHPEALRADYESVRPWLFTVGRRLAIDARRARLARPPEIGGTVLESARVCADHAERSAAALDVREAVATLSPEHRAVLLQVYFRGASVAEAAAALGIPPGTVKSRAYYALRALRRVLPGYEANTVGPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-09-29" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JXC5</accession>
    <name>A0A2M9JXC5_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Putative N-acetylmannosamine-6-phosphate 2-epimerase</fullName>
            <ecNumber evidence="5">5.1.3.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">ManNAc-6-P epimerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">nanE</name>
        <name evidence="6" type="ORF">CG723_11605</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CB01635</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 5">Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 5">
            <text>an N-acyl-D-glucosamine 6-phosphate = an N-acyl-D-mannosamine 6-phosphate</text>
            <dbReference type="Rhea" id="RHEA:23932"/>
            <dbReference type="ChEBI" id="CHEBI:57599"/>
            <dbReference type="ChEBI" id="CHEBI:57666"/>
            <dbReference type="EC" id="5.1.3.9"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 5">Amino-sugar metabolism; N-acetylneuraminate degradation; D-fructose 6-phosphate from N-acetylneuraminate: step 3/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the NanE family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.1.3.9" evidence="5"/>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN11539.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN11539">
        <property type="protein sequence ID" value="PJN11539"/>
        <property type="gene ID" value="CG723_11605"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00629">
        <property type="reaction ID" value="UER00682"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047465">
        <property type="term" value="F:N-acylglucosamine-6-phosphate 2-epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009385">
        <property type="term" value="F:N-acylmannosamine-6-phosphate 2-epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006051">
        <property type="term" value="P:N-acetylmannosamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019262">
        <property type="term" value="P:N-acetylneuraminate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01235">
        <property type="entry name" value="ManNAc6P_epimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007260">
        <property type="entry name" value="NanE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011060">
        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36204">
        <property type="entry name" value="PTHR36204"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04131">
        <property type="entry name" value="NanE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51366">
        <property type="entry name" value="SSF51366"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="5" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PJN11539.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="230" mass="22699" checksum="182424C7B33F7C24" modified="2018-04-25" version="1">MNDPAPSSPVADLLKGRLIVSCQAPPCDPLRDTDTLVRLARAAAAGGAAGIRANEPEVVAAISAAVDLPLIGLWKDGDTGVYITPTVRHALAVAEAGAHIVAADATARPRPDGGTFADIVAAVHAAGALVMADVATLDEGVAAAAAGADLVSTTLSGYVPGSPRQDGPDLELVAALSATVDVPVVAEGRISTPEEAALALARGAHSVVVGTAITAPTALTSRFAAALPCT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-09-29" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JXF8</accession>
    <name>A0A2M9JXF8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Universal stress protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_11800</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal stress protein A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN11569.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN11569">
        <property type="protein sequence ID" value="PJN11569"/>
        <property type="gene ID" value="CG723_11800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006015">
        <property type="entry name" value="Universal_stress_UspA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006016">
        <property type="entry name" value="UspA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00582">
        <property type="entry name" value="Usp"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01438">
        <property type="entry name" value="UNVRSLSTRESS"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Usp" evidence="2">
        <location>
            <begin position="5"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="domain" description="Usp" evidence="2">
        <location>
            <begin position="149"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN11569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="290" mass="29769" checksum="2C5DEB5514BEDF30" modified="2018-04-25" version="1">MDRWITAGVDGSPESSAAAAWAAREAVRRGYGLRLLHAWSPLPDVAASAPDLAAQAEWATSVADEAGRAVAGGHPQLALSVESPSDEAVPALLAAAADAEFLVLGSRGHGALVGFLVGSVGQQVIAESARAVVLVRADDRAEPEAAGREIVVGQEGAPEDSRAVLEFAFAAASARGATLRAVRAWTLPPLYAYSPASLRLLDEAGGMEPYEKKALGEALESLRTRYPDVPVVEHVEIGSAGQVLLASAAGAQLVVVGRRARRSAVGSRIGSVAHAVMHHAPCPVAVVPPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JXU0</accession>
    <name>A0A2M9JXU0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Threonylcarbamoyl-AMP synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_12555</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN11690.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN11690">
        <property type="protein sequence ID" value="PJN11690"/>
        <property type="gene ID" value="CG723_12555"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003725">
        <property type="term" value="F:double-stranded RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017945">
        <property type="entry name" value="DHBP_synth_RibB-like_a/b_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006070">
        <property type="entry name" value="YrdC-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01300">
        <property type="entry name" value="Sua5_yciO_yrdC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55821">
        <property type="entry name" value="SSF55821"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00057">
        <property type="entry name" value="TIGR00057"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51163">
        <property type="entry name" value="YRDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YrdC-like" evidence="1">
        <location>
            <begin position="14"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN11690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="206" mass="22907" checksum="68B7CAC5B4B9AF16" modified="2018-04-25" version="1">MAKYFDVHPENPQRRTISGVADSIRADELVAYPTDSCYALGCRLGSRDGISRIRAIRHLDDRHHFTLMCQNFAQLGQFVQIDNDVFRAIKAATPGSYTFILPATKEVPRQLLHPKKKTVGVRIPDHAVVQALLAELGEPILSSTLLLPDEEEPLTQGWEIKERLDHEVDVVVDSGDCGTEPTTVIDFSGGEMEIVRRGAGDPSRFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JY27</accession>
    <name>A0A2M9JY27_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ferredoxin reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_13120</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN11786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN11786">
        <property type="protein sequence ID" value="PJN11786"/>
        <property type="gene ID" value="CG723_13120"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016156">
        <property type="entry name" value="FAD/NAD-linked_Rdtase_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028202">
        <property type="entry name" value="Reductase_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14759">
        <property type="entry name" value="Reductase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55424">
        <property type="entry name" value="SSF55424"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyr_redox_2" evidence="1">
        <location>
            <begin position="13"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="domain" description="Reductase_C" evidence="2">
        <location>
            <begin position="341"/>
            <end position="397"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN11786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="414" mass="43278" checksum="FC2D15F004C15268" modified="2018-04-25" version="1">MAETAHVPRSPGRVVIAGASMGGLRAAEQLRAAGWTGAITVIGDEPHMPYNRPPLSKDVLAGKVPFESLAFTPRASAADVEWRLGTTATSARLDERVVGLDDGTELAFDGLVVATGMRPRRLRCDGPSGPGSGRHTVRTLADARGLRDELTRPGVRVVVIGAGFIGCEVAATAKGLGVGEVTVVDPETLPMLRPLGELLARSLHRRHEERGVRFALGAGVAGFAGEDRVTGVVLTDGTVLPADVVVESVGSVANTEWLDGNGLDLSDGVLTDEQLRVGGHPDVVAVGDIARFPNARYDGVPRRVEHWSIPTDTAKHAAKSLVAHLVGSVAQPPPFAPLPTFWSDQHEFRLQSFGAPALGIADVRVLDGDPEGDVLVGYHADDRLVGVVALGGPAATTGAARYRAQLLAQPALTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-05-25" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JY31</accession>
    <name>A0A2M9JY31_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Aldo/keto reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_13030</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN11771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN11771">
        <property type="protein sequence ID" value="PJN11771"/>
        <property type="gene ID" value="CG723_13030"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NADP_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="SSF51430"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldo_ket_red" evidence="2">
        <location>
            <begin position="33"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN11771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="314" mass="32681" checksum="AF6B17AE892AE24A" modified="2018-04-25" version="1">MTTAGTPSSDTTATGAARPGGPGQLAGRTVSRVGFGAMQLERLRDDRRAGLALLRRAVDLGIDHVDTAHFYGNAFVNGLLREALRPEDGVLVVSKVGADPDPGGRIPLRPAQRPEELRASVEDNLKSLGVDQVPVVNLRRLDSGPGLRAEGDQVVDIDDQLAAMTAMRDEGMIGAIGLSSVTAEGLRRAIPAGIVCVQNAYSLVARDDETMVEICAVEGIAWVPYFPLGSAFPGIPKVTQEPAVLAAAQSLGSTPSQVGLAWLLQHSPNTLLIPGTADPDHLEANIAAGAIALDEAMVASLDAVPSRSADVPLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JY69</accession>
    <name>A0A2M9JY69_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">N-isopropylammelide isopropylaminohydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_13275</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN11811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN11811">
        <property type="protein sequence ID" value="PJN11811"/>
        <property type="gene ID" value="CG723_13275"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013108">
        <property type="entry name" value="Amidohydro_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07969">
        <property type="entry name" value="Amidohydro_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="SSF51338"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydro_3" evidence="1">
        <location>
            <begin position="94"/>
            <end position="394"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN11811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="403" mass="43803" checksum="4F4725746B77B0E5" modified="2018-04-25" version="1">MLIRDVRPWGGERSDVVLSGDRIVAIRPHDPAAQPDGEVVAGRGRLLLPSFSDVHVHLDSTRIGLPFRPHTGGPGVWTMTMNDRENWRSAEVPLVERVAGTLERMIARGTTRVRSYAQVDVDCKLEKFEAVVAAKEKFADQAEVQIMTFPQAGILREKGTVEYLEASLKGGADVMGGIDPCTLDRDPKGHLDVVFGLAEKYQVEVDIHLHEPGELGVFSTDLILERTRALGMQGKVTMSHAYELGSVSESVSRRIIDDFAELDIAMATVAPSARGQLSLVDLTEAGVRVGLGEDGQRDYWSPYGNCDMLDRTWQLAFTNNFRRDELIEMSLAVATIGGASIMSHDVARPAGVADRPGLAVGDRADLLLVDGETPSSAVMDRGTDRTVLHDGVVVADQLALVRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JZJ9</accession>
    <name>A0A2M9JZJ9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">SAM-dependent methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_04350</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000002">
        <property type="protein sequence ID" value="PJN12294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN12294">
        <property type="protein sequence ID" value="PJN12294"/>
        <property type="gene ID" value="CG723_04350"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransf_11" evidence="1">
        <location>
            <begin position="59"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN12294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="249" mass="27733" checksum="4F2CB19676674628" modified="2018-04-25" version="1">MTHSTRTSPPDPSLRRSLALFRAFLREQQDPEACYSLLARDAADQVEAVCGDVRGKVVVDVGGGSGYFTREFRRRGAHGFLFEPDARELGERPSAPAVVADGYLLPLAEGAADVTFSSNVLEHVDDPQTFLSELVRVTRPGGIVYLSFTNWLSPWGGHEWAPWHYLGADRAGARYQRRTGRPPKHTLGENLFAHHIGPTLRQVRARDDITVVSARSRYWPFLAATVAKVPGVREFATWNLLLILRRCSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-09-29" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JZW7</accession>
    <name>A0A2M9JZW7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Bifunctional RNase H/acid phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_05160</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000002">
        <property type="protein sequence ID" value="PJN12433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN12433">
        <property type="protein sequence ID" value="PJN12433"/>
        <property type="gene ID" value="CG723_05160"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004523">
        <property type="term" value="F:RNA-DNA hybrid ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07067">
        <property type="entry name" value="HP_PGM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014636">
        <property type="entry name" value="RNaseH/PGlycerate_mutase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002156">
        <property type="entry name" value="RNaseH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00300">
        <property type="entry name" value="His_Phos_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13456">
        <property type="entry name" value="RVT_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036922">
        <property type="entry name" value="RNaseH_PGAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00855">
        <property type="entry name" value="PGAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="SSF53254"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50879">
        <property type="entry name" value="RNASE_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNase H type-1" evidence="2">
        <location>
            <begin position="1"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="131"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="222"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN12433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="412" mass="43394" checksum="8BEE63E7A1D114F6" modified="2018-04-25" version="1">MREFIVEADGGSRGNPGPAGYGSVVIDAATGETLAETAEYIGIATNNVAEYRGLVAGLRAAHALDPQASVHVRMDSKLVVEQMSGRWKIKHPDMRPLAAEAATVLPASQVTYEWIPRERNKHADRLANEAMDAGKRGKQWEASRSTAELDTPRPQADRGAPPGDAAAGAAKARAALAGTRGTADARAAGNVAGTASQGWSAAPDLGAPATFVLLRHGETALTPEKRFSGSGGSDPELSAAGRSQAERVAAALAARGTVQAIVSSPLKRCQETARTVAARLGLDVHIEEGLRETDFGAWEGLTFGEVRERYPEDMNAWLASSKAEPTGGGESFAAVARRVAATRDRLVERYAGRTVLLVTHVTPIKTFVRLALGAPPESLFRMELSAASLSAVAYYGDGNASVRLLNETAHLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K053</accession>
    <name>A0A2M9K053_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_05615</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000002">
        <property type="protein sequence ID" value="PJN12511.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN12511">
        <property type="protein sequence ID" value="PJN12511"/>
        <property type="gene ID" value="CG723_05615"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014780121" evidence="2">
        <location>
            <begin position="37"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="92"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN12511.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="245" mass="23809" checksum="C7A433E4C4CC7750" modified="2018-04-25" version="1">MSRRRRMGPRKKAALAVSAALVAGGAAFALASTGNAAPVAQNAQVCQGLETAIANNQKFIDGQRAAPDAQSEARIANREAVIAEIRRKEAASGCEAGDGAQAGAGADDAAGAGAGADDAAGAGSDDAAGGMETVTAAPPDTVTAEPDPTDAAGGAGDAGGDAAGEQVCAGSTVTLSGEGGAPAASSGQFPAGTKLKVTNLDNGKSTSVEVTSVSGSCVLLNNSAFEQVREPGKFLIRNARIEKVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K0H1</accession>
    <name>A0A2M9K0H1_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Pyridoxal phosphate homeostasis protein</fullName>
            <shortName evidence="1">PLP homeostasis protein</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CG723_06260</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CB01635</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the pyridoxal phosphate-binding protein YggS/PROSC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000002">
        <property type="protein sequence ID" value="PJN12631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN12631">
        <property type="protein sequence ID" value="PJN12631"/>
        <property type="gene ID" value="CG723_06260"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02087">
        <property type="entry name" value="PLP_homeostasis"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001608">
        <property type="entry name" value="Ala_racemase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029066">
        <property type="entry name" value="PLP-binding_barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011078">
        <property type="entry name" value="PyrdxlP_homeostasis"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10146">
        <property type="entry name" value="PTHR10146"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01168">
        <property type="entry name" value="Ala_racemase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004848">
        <property type="entry name" value="YBL036c_PLPDEIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51419">
        <property type="entry name" value="SSF51419"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00044">
        <property type="entry name" value="TIGR00044"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01211">
        <property type="entry name" value="UPF0001"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ala_racemase_N" evidence="4">
        <location>
            <begin position="11"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="1 2">
        <location>
            <position position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR004848-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PJN12631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="239" mass="25100" checksum="FE26CA655DBA68A1" modified="2018-04-25" version="1">MTDRKAQLAANLAQVEERIASACVAAGRKREEVTLIVVTKTYPASDVRILSELGVRDVAENRDQDAAPKAAECADLPLRWHFVGQLQTNKVRSVVGYADVVQSVDRSKLVTSLSTAAVRAERELGCLIQVALDAGENGRGERGGVGPGGIGELAAIVADAPGLRLDGLMTVAPLTGPYADRQQAAFERLMDLSTDLRRAHPAANMVSAGMSADLEQAVAAGATHVRVGTAVLGVRPRLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K118</accession>
    <name>A0A2M9K118_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Fe-S cluster assembly protein SufD</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">sufD</name>
        <name evidence="1" type="ORF">CG723_07330</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000002">
        <property type="protein sequence ID" value="PJN12816.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN12816">
        <property type="protein sequence ID" value="PJN12816"/>
        <property type="gene ID" value="CG723_07330"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000825">
        <property type="entry name" value="SUF_FeS_clus_asmbl_SufBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037284">
        <property type="entry name" value="SUF_FeS_clus_asmbl_SufBD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011542">
        <property type="entry name" value="SUF_FeS_clus_asmbl_SufD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43575">
        <property type="entry name" value="PTHR43575"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01458">
        <property type="entry name" value="SUFBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101960">
        <property type="entry name" value="SSF101960"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01981">
        <property type="entry name" value="sufD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PJN12816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="392" mass="41594" checksum="2CB2D34ACE52C1DF" modified="2018-04-25" version="1">MAEAQNIPVGSTTSGSIAVAAESTVATRMSAPPSYDVADFPVPHGREEEWRFTPLERLRGLHDGTAVAQGGLRVEVTAPAGVTQETVGRDDARVGKAGKPVDRVAAQAFSSFEKASVVSVPKETVLTEPIRIAVHGEGGTAFAHQVIELGAFAEAVVVIDHTGDAVLAANVDYILGDGAKLTVVSVQDWDEKAVHVAQHNALIGRDASFKSVVVTFGGDLVRLHPRVNYAGSGGEAELLGLYVTDAGQHQEHRLLVDHAAPHCKSNVAYKGALQGQDAHAVWIGDVLIEATAEGTDTYELNRNLVLTDGARVDSVPNLEIETGEIVGAGHASATGRFDDEQLFYLRSRGIPADEARRLVVRGFFAELVQQIGLPDVQERLLAKIEAELEASV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K196</accession>
    <name>A0A2M9K196_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Phosphate transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CG723_07740</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CB01635</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Membrane</location>
            <topology evidence="1 6">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the inorganic phosphate transporter (PiT) (TC 2.A.20) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000002">
        <property type="protein sequence ID" value="PJN12891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN12891">
        <property type="protein sequence ID" value="PJN12891"/>
        <property type="gene ID" value="CG723_07740"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005315">
        <property type="term" value="F:inorganic phosphate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006817">
        <property type="term" value="P:phosphate ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001204">
        <property type="entry name" value="Phos_transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11101">
        <property type="entry name" value="PTHR11101"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01384">
        <property type="entry name" value="PHO4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0592">Phosphate transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="45"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="81"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="108"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="132"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="196"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="220"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="307"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="333"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="404"/>
            <end position="424"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PJN12891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="424" mass="42733" checksum="E247FE227D214323" modified="2018-04-25" version="1">MEHITLLLGIVIVTALVFDFTNGFHDTANAMATTISTGALKPKTAVAMSAVLNLVGAFLSVEVAKTISGGIINEDGLKTEVIFAALVGAILWNLLTWLVGLPSSSSHALFGGLIGAAVMSMGWSSINGGTVVTKILLPAVAAPLVAGIAATLATRLTYRIGSKTDQKATAKGYRAGQIASAGLVSLAHGTNDAQKTMGIITLALITGGVLSPGANPPMWVIVSAGAAIALGTYLGGWRIIRTMGKGLTDLAPQQGFAAQTSAATAILASSHIGFSLSTTQVCSGAVMGSGLGRKGGVVRWSTATRMFIAWGLTLPAAGLVGAGAEFLTKQGSWGVAVTALLLIAGAGIIWALSRRNSIDHTNVTDDDIDGVDVPDEPAGVVTTAIAAVTPPPAGTVADLDTDVKTTIPASPAPPSAEPVRPATV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K1X2</accession>
    <name>A0A2M9K1X2_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Coproporphyrin III ferrochelatase</fullName>
            <ecNumber evidence="7">4.99.1.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">cpfC</name>
        <name evidence="9" type="ORF">CG723_00580</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CB01635</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Involved in coproporphyrin-dependent heme b biosynthesis. Catalyzes the insertion of ferrous iron into coproporphyrin III to form Fe-coproporphyrin III.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>Fe-coproporphyrin III + 2 H(+) = coproporphyrin III + Fe(2+)</text>
            <dbReference type="Rhea" id="RHEA:49572"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:68438"/>
            <dbReference type="ChEBI" id="CHEBI:131725"/>
            <dbReference type="EC" id="4.99.1.9"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="6">
            <dbReference type="Rhea" id="RHEA:49574"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 7">Porphyrin-containing compound metabolism; protoheme biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7 8">Belongs to the ferrochelatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.99.1.9" evidence="7"/>
    <dbReference type="EMBL" id="NNBL01000001">
        <property type="protein sequence ID" value="PJN13132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN13132">
        <property type="protein sequence ID" value="PJN13132"/>
        <property type="gene ID" value="CG723_00580"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00252"/>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004325">
        <property type="term" value="F:ferrochelatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006783">
        <property type="term" value="P:heme biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00419">
        <property type="entry name" value="Ferrochelatase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03411">
        <property type="entry name" value="Ferrochelatase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00323">
        <property type="entry name" value="Ferrochelatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001015">
        <property type="entry name" value="Ferrochelatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033644">
        <property type="entry name" value="Ferrochelatase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033659">
        <property type="entry name" value="Ferrochelatase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11108">
        <property type="entry name" value="PTHR11108"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00762">
        <property type="entry name" value="Ferrochelatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 7" id="KW-0350">Heme biosynthesis</keyword>
    <keyword evidence="2 7" id="KW-0408">Iron</keyword>
    <keyword evidence="4 7" id="KW-0456">Lyase</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 7" id="KW-0627">Porphyrin biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="7">
        <location>
            <position position="62"/>
        </location>
        <ligand>
            <name>Fe-coproporphyrin III</name>
            <dbReference type="ChEBI" id="CHEBI:68438"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="131"/>
        </location>
        <ligand>
            <name>Fe-coproporphyrin III</name>
            <dbReference type="ChEBI" id="CHEBI:68438"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="194"/>
        </location>
        <ligand>
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="289"/>
        </location>
        <ligand>
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PJN13132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="378" mass="40656" checksum="4C42CF6DEF17C64E" modified="2018-04-25" version="1">MSDALDPTPFDGYDALLLLSFGGPEGPDDVVPFLENVTRGRGIPKERLKEVGQHYFLFGGVSPINEQNRALLDALRKDFADHGLDLPVHWGNRNWTPYLTDTLREMVTDGHERILVLATSAYASYSGCRQYRENLADSLAALEAEGLEVPRVDKLRHYFNHPGFVRPMIDGVLKSLADLPDDVRDGAHIAFTTHSIPTAAADVSGPVGDHGDGGAYVKEHLDVARAIADAVREETGIDHPWQLVYQSRSGAPHIPWLEPDICDHLEERHSAGVPAVVMAPIGFVSDHMEVLYDLDTEATAKAAELGLPVRRSATVGADPRFAAAVRDLVLERSAAESGRAVTPCALGALGASHNLCPVGCCPSRAPKPAAAGADSPYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K244</accession>
    <name>A0A2M9K244_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">MerR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CG723_00910</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000001">
        <property type="protein sequence ID" value="PJN13185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN13185">
        <property type="protein sequence ID" value="PJN13185"/>
        <property type="gene ID" value="CG723_00910"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015689">
        <property type="term" value="P:molybdate ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041657">
        <property type="entry name" value="HTH_17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008995">
        <property type="entry name" value="Mo/tungstate-bd_C_term_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004606">
        <property type="entry name" value="Mop_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010093">
        <property type="entry name" value="SinI_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005116">
        <property type="entry name" value="Transp-assoc_OB_typ1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12728">
        <property type="entry name" value="HTH_17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03459">
        <property type="entry name" value="TOBE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="SSF46955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50331">
        <property type="entry name" value="SSF50331"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01764">
        <property type="entry name" value="excise"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51866">
        <property type="entry name" value="MOP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0500">Molybdenum</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mop" evidence="3">
        <location>
            <begin position="65"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PJN13185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="131" mass="13929" checksum="3DF693A63E0FE5BC" modified="2018-04-25" version="1">MQSYTIGQAARLLGVSPDTARRWADAGRVATHRDEGGRRMIRGQDLAAFSIEVGQSGGDDEDASYTSARNAFPGIVTGVKLGDVAAQVEIQAGPHRLVSLLTREAVEELGLEVGMQAIARVKSTNVHIDLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K294</accession>
    <name>A0A2M9K294_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_01315</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000001">
        <property type="protein sequence ID" value="PJN13254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN13254">
        <property type="protein sequence ID" value="PJN13254"/>
        <property type="gene ID" value="CG723_01315"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="97"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN13254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="117" mass="13046" checksum="6AB7154326F46A87" modified="2018-04-25" version="1">MADIEPYESALGAIPGAHPYPRTSRYHDAEIGVHRLPDGTEVRYAKRRLLPPLDAQETQEHVVGAGERADLLAQRYFGDSGQWWRIADANPVLDPRELTDEAGQVIDIPEPGGHRRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K2N4</accession>
    <name>A0A2M9K2N4_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Amine oxidase</fullName>
            <ecNumber evidence="3">1.4.3.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CG723_01505</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CB01635</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>L-topaquinone</name>
            <dbReference type="ChEBI" id="CHEBI:79027"/>
        </cofactor>
        <cofactor evidence="3">
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
        </cofactor>
        <text evidence="3">Contains 1 topaquinone per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>L-topaquinone</name>
            <dbReference type="ChEBI" id="CHEBI:79027"/>
        </cofactor>
        <text evidence="2">Contains 1 topaquinone per subunit.</text>
    </comment>
    <comment type="PTM">
        <text evidence="2 3">Topaquinone (TPQ) is generated by copper-dependent autoxidation of a specific tyrosyl residue.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the copper/topaquinone oxidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.4.3.-" evidence="3"/>
    <dbReference type="EMBL" id="NNBL01000001">
        <property type="protein sequence ID" value="PJN13287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN13287">
        <property type="protein sequence ID" value="PJN13287"/>
        <property type="gene ID" value="CG723_01505"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008131">
        <property type="term" value="F:primary amine oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009308">
        <property type="term" value="P:amine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000269">
        <property type="entry name" value="Cu_amine_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015798">
        <property type="entry name" value="Cu_amine_oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036460">
        <property type="entry name" value="Cu_amine_oxidase_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10638">
        <property type="entry name" value="PTHR10638"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01179">
        <property type="entry name" value="Cu_amine_oxid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49998">
        <property type="entry name" value="SSF49998"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0186">Copper</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="1 3" id="KW-0801">TPQ</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014929081" description="Amine oxidase" evidence="5">
        <location>
            <begin position="36"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="domain" description="Cu_amine_oxid" evidence="6">
        <location>
            <begin position="62"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="267"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="1">
        <location>
            <position position="120"/>
        </location>
    </feature>
    <feature type="active site" description="Schiff-base intermediate with substrate; via topaquinone" evidence="1">
        <location>
            <position position="196"/>
        </location>
    </feature>
    <feature type="modified residue" description="2',4',5'-topaquinone" evidence="2">
        <location>
            <position position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR600269-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR600269-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PJN13287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="435" mass="47101" checksum="E209E681FC0975CB" modified="2018-04-25" version="1">MHVNRLRRARARAAVALTSLALLGTAVSAAGPATAAPQAPAAAAPACSTAYKIEQVLDGGTTWRMCWHYNTLSGLVLDNVSYQPKDEPKPIAVLTSARLAQVHVPYDDGENEYDDVTGTDFGYALQNLKPGECPGGTIKTVKVPDRGNVQGLCTTTRARGHAYRLNDDESTGGSGKVYTAQGKDLLVYTVNKASWYEYITEWRFSSDGTITSNVGATGSLSPYDYNGTDGKGWPIGKGARAYAESHAHNVFWRLNFGLDGSPKSKVEQYDSKVTAPSGSGSPTTKTTRTPVTKELAGDAKDMRWWRVVSTAGKNKDGHPRSYEFVPGRTAKFPGRSFTKHDVYFTEYKKCEQYASDNPAGHCGGASVDKWVGGQTLTHPITWVNIGFHHIARDEDQQPMPVHWQGFSLAPRDVTAMNPLTPADLADQNGVPRNGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K302</accession>
    <name>A0A2M9K302_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Peptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CG723_02770</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000001">
        <property type="protein sequence ID" value="PJN13505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN13505">
        <property type="protein sequence ID" value="PJN13505"/>
        <property type="gene ID" value="CG723_02770"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014980735" evidence="2">
        <location>
            <begin position="27"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="domain" description="AB hydrolase-1" evidence="3">
        <location>
            <begin position="85"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="482"/>
            <end position="525"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PJN13505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="525" mass="56773" checksum="CA47FA423F98DC02" modified="2018-04-25" version="1">MKKRVAAVCGAATMVAGMLAAAPAAAAPTLSVQRAALTWKDCGTKKYPTLQCSSVRVPLDHNRPAGKQITLALSRVRHTAKTSQGPLLVNPGGPGGSGLALAGFVARELPKSVAAQYDVVGFDPRGVGKSKPALNCRPKHFATVRPPSVPSTPAIERANLDRAQAFAKACTTKYADVLPYFDTVSAARDLDAIRAALGAQQLNYFGYSYGTYLGAVYAKLYPQRVRRLVLDSIVDPGGVWYDDNMGQDHAFNARHQAFLAWVARHDATYKLGKDPAKVEAEWYAMRDALQKKPAGKKVGAAELEDTFLPGGYYNGYWPYLAGAFAAYVKDKDPAPLVKTYKELGAVDASGDNGYSVYTAVQCRDAGWPRDWNRWRDDNWQAYEKAPFSTWNNAWYNAPCAFWPMSPLAPTDVSNDELPPTLLFQATDDGATPYEGGVAVHRELRGSSLVVEQGGENHGVSLSGNVCLDRYLADYLRTGKVPRGSGETDATCKKLPEPKPLAKKGRAAGPPPSRGMRLHGLMGFRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-05-25" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K344</accession>
    <name>A0A2M9K344_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Peripla_BP_6 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_02990</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000001">
        <property type="protein sequence ID" value="PJN13542.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN13542">
        <property type="protein sequence ID" value="PJN13542"/>
        <property type="gene ID" value="CG723_02990"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028081">
        <property type="entry name" value="Leu-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13458">
        <property type="entry name" value="Peripla_BP_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014909420" description="Peripla_BP_6 domain-containing protein" evidence="1">
        <location>
            <begin position="25"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="domain" description="Peripla_BP_6" evidence="2">
        <location>
            <begin position="45"/>
            <end position="401"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN13542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="418" mass="44091" checksum="4232536F3067DDC4" modified="2018-04-25" version="1">MSRTVRAITATVAALLLATACNSAATGNSPDSKGSSVRGVTDDAIKVGGIVSMTTASGYSKKDTDLGAKARFARANAEGGINGRKIDYLGAEDDGQDPAKNLAAARKLVQQDKVFAISPMSSVTFSGADFLQKQKVPTFGWGTLPSFCGPTYIYGFGGCMVPMPGGTISQTWPEGLKQVTHGAKGKTVAILANDNDAGTFAIRTYKQSFASAGYKVTYAKSSVPATSVPSDWSAYTKEILRSDGGKAPDIVVSVMQTPYNIGLFTAVKRSGYRGVLTDPTDYDPGLLAKSATKEALDGVHILLTFEPFETRTAAMKQFKADIKKASGGKDVPLNMHMMTGYMSADLFLSIAQKAGRDLTVASFQKAADGFSDTGTMVGDRALPKGQKESFGCGALVQLKDGAYHVSSPFKCYEPIPFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K3D3</accession>
    <name>A0A2M9K3D3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">GPP34 family phosphoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_03540</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000001">
        <property type="protein sequence ID" value="PJN13635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN13635">
        <property type="protein sequence ID" value="PJN13635"/>
        <property type="gene ID" value="CG723_03540"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043231">
        <property type="term" value="C:intracellular membrane-bounded organelle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070273">
        <property type="term" value="F:phosphatidylinositol-4-phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3630.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008628">
        <property type="entry name" value="GPP34-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038261">
        <property type="entry name" value="GPP34-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05719">
        <property type="entry name" value="GPP34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN13635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="229" mass="24480" checksum="D379552AD940F295" modified="2018-04-25" version="1">MAHGSLSLPARLLLLGFDTEKGRVSGAPDIELAVRAAALVELARRRIISDVDGIVTPVFDARTGDPVLDELMELAEESRPRTWRAWIGYRARATLDTVRRQLASEGYLSAERKRVFGLFPVTRYGLERAGYVEVLRAEVLGALEGGEPVGRVDEDDAVLAVLAATGKLRRLIPGKARRTHKDRLDHLAARAGDISPELRQSLGDIRAALAAAVKAAEASRASAGGGGGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K3F0</accession>
    <name>A0A2M9K3F0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">AraC family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_03670</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000001">
        <property type="protein sequence ID" value="PJN13656.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN13656">
        <property type="protein sequence ID" value="PJN13656"/>
        <property type="gene ID" value="CG723_03670"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002818">
        <property type="entry name" value="DJ-1/PfpI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01965">
        <property type="entry name" value="DJ-1_PfpI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="1">
        <location>
            <begin position="218"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN13656.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="335" mass="36533" checksum="751A86F68C0B50A4" modified="2018-04-25" version="1">MAARTVLILLFDDVQSLDVTGPAEVFAGAALCRGPRPGDTYRIRTASLDGGPVRTSSGLTLVPDHALADAPAPHTLLVPGGRGTRRPDPRLTAWLREHGPRAQRLVSVCTGAILLAEAGLLDGRRVTTHWAYCERLARDHPAVEVDPDPIYVRDGNVATSAGVTAGIDLALALVEEDHGRDTALTVARHLVVFLRRPGNQAQFSAQLSAQTARREPLREVQHWITEHPDDDLSVESLASRARLSPRHFARAFQAETGMTPGRYVDLVRLEQARRLLEDTSDGVEEISRTCGYGTPEAMRRAFTRALGASPAEYRRRFCAPGTRTTGRRPSEPTHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K3Q1</accession>
    <name>A0A2M9K3Q1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">p-hydroxycinnamoyl-CoA synthetase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_01580</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000001">
        <property type="protein sequence ID" value="PJN13753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN13753">
        <property type="protein sequence ID" value="PJN13753"/>
        <property type="gene ID" value="CG723_01580"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-binding" evidence="1">
        <location>
            <begin position="12"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding_C" evidence="2">
        <location>
            <begin position="407"/>
            <end position="482"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN13753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="494" mass="52331" checksum="FB21917BCA2BA5CF" modified="2018-04-25" version="1">MRNEGLGSWPARRARKTPHRTALIHAGAAVTYAALHERTTRLAHALRALGVRRGDRVAYLGPNHPSFLEALFAAGLLGAVFVPLNTRLTEPELAFQIRDSGATVLLHAAARGGDLPGVRTAVEADGPAYEELLAAAPALAIDEQVGPDDVGVIMYTSGTTGRPKGAMLTHGNLTWNAVNVLVDQDLVADEIALVVAPLFHTAGLNMLTLPVLLKGGSCVLVGSFDAAATLELVERHRVTFMFGVPTMFDQLTRQPNWPDADLSSLRMLSCGGSPVPTPLIAAYQDRGLTFLQGYGMTEAAPGTLFLDAEHAVSKAGTAGVPHFFSDVRVARPDLAPVEPGETGEVLVRGPHVMPGYWGLPDESAAAFADGWFRTGDAARIDADGYVTIVDRFKDMIISGGENIYPAEVEDALLAHADIAECAVIGVPDEKWGEVGRAVLVAREGRAPDPNEVLASLSGRLAPYKIPKSAVVVDALPRTASGKLVKADVRRLHGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JES0</accession>
    <name>A0A2M9JES0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CG723_45040</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000050">
        <property type="protein sequence ID" value="PJN05378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN05378">
        <property type="protein sequence ID" value="PJN05378"/>
        <property type="gene ID" value="CG723_45040"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006439">
        <property type="entry name" value="HAD-SF_hydro_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041492">
        <property type="entry name" value="HAD_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023198">
        <property type="entry name" value="PGP-like_dom2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13419">
        <property type="entry name" value="HAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01509">
        <property type="entry name" value="HAD-SF-IA-v3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PJN05378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="214" mass="23489" checksum="342959D616660ABF" modified="2018-04-25" version="1">MRYDLVIFDNDGVLVDSEPISNKLLAGYLTELGHPTSYEESLRDYMGAAMHRVHDLVEERTGQRLPEDFDEVFHGRVFAAFERELEPVPGAGEVLEKLAADGVPYCVASSGSHERIRVGHRKTGHDKWFDNGRIFSSQDVGRGKPAPDLFLYAAQRMGVAPERCAVVEDSPLGVQAAMAAGMDVYGFTAMTPGSRLSAATELFGDMRELPDLLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-06-02" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JFB2</accession>
    <name>A0A2M9JFB2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_44095</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000045">
        <property type="protein sequence ID" value="PJN05585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN05585">
        <property type="protein sequence ID" value="PJN05585"/>
        <property type="gene ID" value="CG723_44095"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="38"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="38"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN05585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="122" mass="13092" checksum="2A0A75C9EFC1F266" modified="2018-04-25" version="1">MFHEVTEGCWKMEGLAAEFEVNSCCGAEDLVDLELHDRGGGLSKDRHQETSDSDFQGDGGVGQESLGDLNALLVVQWRCGVAPHWCGDLKSVSVMVSHCPFHERAGVLTDAGASKSHSSMCP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JFB8</accession>
    <name>A0A2M9JFB8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CG723_44065</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000045">
        <property type="protein sequence ID" value="PJN05580.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN05580">
        <property type="protein sequence ID" value="PJN05580"/>
        <property type="gene ID" value="CG723_44065"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PJN05580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="407" mass="43202" checksum="EB5C61E8059EAD29" modified="2018-04-25" version="1">MTATRPGATDLSGAFVYTWDLVGDPGAAERIAALGVGSVVLQAAYHSARAMTPYHPVHRTVHATHSAAYFPFDPDPWHGTRLRPPAPGWAVDVPDRFGTAATALRGQGLRVEAWLVLTHGTALGEQAPDLTVRNAFDEQYGYALCPAQPEVAEYATQLVGSFCARYDTAEVPTLMLEACGWLGFEHGSHHEKTAGADLTRAARDLLSVCLCPACRAGIAAAGADPEGLAQAVRRTVDTELRGGARVPGTLHEALGDQTAGALLRHRQSVIEQLTRNVAAVAPGRELLLMADGDPGATGPDVGLDLGRFQGRADALVLKCWDDEHRSVARIQAAVRATDRPVIANVSVLEEHPARVAGRVARLLDAGAHQIRYYHAGLASPARLQALRRADAYAREAARAARTTKGAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JFZ9</accession>
    <name>A0A2M9JFZ9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">B/F/G family RNA polymerase sigma-70 factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CG723_43495</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000043">
        <property type="protein sequence ID" value="PJN05677.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN05677">
        <property type="protein sequence ID" value="PJN05677"/>
        <property type="gene ID" value="CG723_43495"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014322">
        <property type="entry name" value="RNA_pol_sigma-B/F/G"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000943">
        <property type="entry name" value="RNA_pol_sigma70"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007624">
        <property type="entry name" value="RNA_pol_sigma70_r3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007630">
        <property type="entry name" value="RNA_pol_sigma70_r4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04539">
        <property type="entry name" value="Sigma70_r3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04545">
        <property type="entry name" value="Sigma70_r4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00046">
        <property type="entry name" value="SIGMA70FCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02980">
        <property type="entry name" value="SigBFG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00715">
        <property type="entry name" value="SIGMA70_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0731">Sigma factor</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="RNA_pol_sigma70" evidence="6">
        <location>
            <begin position="89"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="192"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS00715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PJN05677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="286" mass="31444" checksum="212C98E8CF64E4C5" modified="2018-04-25" version="1">MSAVQGSSKVLTLSKSASAPDVLHSPPVSGASEAIDTRTLSRSLFLRLAALDENSPERGYVRDTLIELNLPLVRYAAARFRSRNEPMEDIVQVGTIGLIKAIDRFDCERGVEFPTFAMPTVVGEIKRFFRDTSWSVRVPRRLQELRLALTKASDELAQKLDRSPTVPELAAVLGVSEDDVVDGLAVGNAYTASSLDSPAPEDDGGEGSLADRLGYEDTALEGVEYRESLKPLLAKLQPRERRIIMLRFFANMTQSQIGEEVGISQMHVSRLLTRTLSQLREGLIAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JGW3</accession>
    <name>A0A2M9JGW3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CG723_40985</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CB01635</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell septum</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SsgA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000035">
        <property type="protein sequence ID" value="PJN06119.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN06119">
        <property type="protein sequence ID" value="PJN06119"/>
        <property type="gene ID" value="CG723_40985"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030428">
        <property type="term" value="C:cell septum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030435">
        <property type="term" value="P:sporulation resulting in formation of a cellular spore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.31.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006776">
        <property type="entry name" value="SsgB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038658">
        <property type="entry name" value="SsgB_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04686">
        <property type="entry name" value="SsgA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0749">Sporulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="51"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="342"/>
            <end position="373"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PJN06119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="530" mass="57086" checksum="7BEADBD576D8287E" modified="2018-04-25" version="1">MSVEKDITMDNANVTEDDFDALLNASSLGAPHVLAETEPIPVEFRRRLAQAAAAHPNASDNDAPGREVARHAQAKRAMSVSVDIEAYAAQQPAGRTGGESAPLAVLWGSVGSGKSAVLAALIASFAKTQRLLVISPHARMMSAERPRDAMHALLTLSGSVYGPGLAAAMATACQRADHHRDVQDTPRLADYLIRCTHLDPTRCAGESMASSPSVRQWHTARMTELLTFVCDSAEPAPGRSHRHQAVQTAVQAVARAWTHRASDTLRMPPRLWPSIDHKADGDTPLAALAQLRRHMGKVGQQSDTSGMPPCAGPATYLRVHTPRLEWPQRLLLASHLPTLWAPPGAPPTPTTDGALRAGTPAGPDAQKPADCGTPTVWAEEDEQGPALHACLQMAFHEEEGGKGASFPTRLTYRLRDPYAVEAAFHTDDDEPVVWVFARDLLIEGLSGSAGEGDVVVWNAEESQEQGQRTYIRLNSPEGTALLSARHEQLKRYLERTQHLCSLGMEHLHAGAALDAFEGELSELTCRGFGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JGX6</accession>
    <name>A0A2M9JGX6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_41095</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000035">
        <property type="protein sequence ID" value="PJN06140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN06140">
        <property type="protein sequence ID" value="PJN06140"/>
        <property type="gene ID" value="CG723_41095"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="117"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="328"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="378"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="419"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="456"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="494"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="921"/>
            <end position="943"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN06140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="943" mass="104434" checksum="D9B33A4FA923FDA0" modified="2018-04-25" version="1">MLRLQAWLELWRSRAVDFVSGEDKLEIYHRCVLAALDGPETERLLGKRDGVDHGAVMERMMTAHYRRYTTIRCPSPLFDRAIEELDEARDKYERVAGEGQWDWRVVCSLIGLGSLTLLIFGGLLALLTAVVVAAVTMAVLFIWRESSAWTNLAQCLIAAGLGGAWLVQRIEVGACAARWGEDLQEIGTGPVVADLVRHMLGDDPDSLFIPDDYEWGLRAPRAPGYIVENGARRQLERKLTHLEDGTIAVCGPRGAGKTTLLEQCVKKAGFGVIVQAPATYAPHDFLLSLSVQLCEKYMRDQGYEPIGFARLSPARRLLRGMRSQAKRLGRWSSFAVPAAALVVLGLSASVRSLYEQYVTSVFDVARTNADAIRDDVTAIWQGHTVIASLTVTIGGIAWWQSRHAAWLPRMLGRLWMRGIRRVGLLLAWASAATVLLDEQIRQQARHLHNSQPEALYRAVGYAGALLAVWWVLRLARDSGVEFPFGRLRIFLEKIFRPFAAAAGIYLLLFLITNPQIRSLLADPENPLRLVGIITGVLLSTAGDWHPQPDEPELITRCQSHLYRLQTIQQATYGLTAGGTAQILSLGTNHSASVSTVPPNYPELVEEFRELLKCIAIERTGAGKTVVIAIDEVDRLGADTDALAFLREIKAILGVPLVHYLISVAEDVGAAFVRRGLPHRDATDSSLDDIIHVQPSTLSDSRAILAKRSQRLKDPHILLAHALSGGILRDLLRYGLQLRETQDKTQSYELTDISRHLILEELAETFAGFRTLLSKQQWTHDTNSVLASFRTLSSYLRDPCPCVEADVLRTLDHFAFYADGPRPHPANAGDSSHRPPDDPVLSSDARQLIDEASAYAYFSLTLLDIFSTEGLECRTQLAAEHGQDGDPERLADARQELGISPYSARPLIDTIRKAWSLPLGPTPDARLPASAVRCSRHRSRPDIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JGZ5</accession>
    <name>A0A2M9JGZ5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DNA-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_41005</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000035">
        <property type="protein sequence ID" value="PJN06123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN06123">
        <property type="protein sequence ID" value="PJN06123"/>
        <property type="gene ID" value="CG723_41005"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="2">
        <location>
            <begin position="18"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="185"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN06123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="273" mass="30039" checksum="CF25D009DA3C4865" modified="2018-04-25" version="1">MRPVAVPEYGAGRLAAALRRGREKSGKSREQVADAIPCSLATVQRAEAGKQRPTQSVTRAFARACGLDEEKMADLWEAAGKPARGTKRTQAPAVNFVRNEADLGAALLRAHEDNARPAFREMERRAERHGGFGRLDRMTAWRIVHRKVLPTTENQLRAFLIACNVSEAAFPEWVRAWRRAKAGAQSATLRRAPQTRTRRPDSTEPATAAKIMRAAGLRPIDDFPGTARPWTAQCVRCGKLSRVRLDYVRRGTGCSVCHAKPRQPEGPPSSGTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JH34</accession>
    <name>A0A2M9JH34_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">D-alanyl-D-alanine carboxypeptidase/D-alanyl-D-alanine-endopeptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">dacB</name>
        <name evidence="3" type="ORF">CG723_40515</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S13 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000034">
        <property type="protein sequence ID" value="PJN06162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN06162">
        <property type="protein sequence ID" value="PJN06162"/>
        <property type="gene ID" value="CG723_40515"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004185">
        <property type="term" value="F:serine-type carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000667">
        <property type="entry name" value="Peptidase_S13"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30023">
        <property type="entry name" value="PTHR30023"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02113">
        <property type="entry name" value="Peptidase_S13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00666">
        <property type="entry name" value="PBP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN06162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="523" mass="55008" checksum="989A1591F2B113F5" modified="2018-04-25" version="1">MAAAVTMSACSNDSTDHSVLPSQNATRVSADLQKFMNTPPWSSGKWGVQVADLKTGEVIQSKGANSQFLTGSTAKTFAVSAALDVLGDDHRFRTPVFHSGTVSPDGRLSGNLIMVGSGDLALGGRTTVSGTLDVPDFDHYDANAVPGMATLTQEDPLAGINELARQVAASGVRQIDGDVVIDNRLWDPVSIGGVPVTPTVINDNLIDVLITPGAPGEQAKVDWRPKTAAFSVDAQVATTPAGSKPTVTTESVTPGHIRVRGSVPADAKAPFVTTYQVPDPAVFARTVLIEALARNGVSVTAPRIGANPSSKLPPSKDVMAMPVSATYTSPPFKEYAKLINKVSHNLGANLLPPLMAVQRGQRTYADGMKIEREFLARAGVDPKSFTLVDAQGLPGDKATPTAQISLLRYLARQDDFDVFYDSMPSMGVDGSLADVIERTNPAAGRIRAKTGTLVSAYKGKLALGTKALAGYIDAKDGHRYVFAIYANNIPVPSNSVSDAIDLALRANKQLGAMAAEIYKSPKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JH72</accession>
    <name>A0A2M9JH72_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CG723_40905</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000035">
        <property type="protein sequence ID" value="PJN06107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN06107">
        <property type="protein sequence ID" value="PJN06107"/>
        <property type="gene ID" value="CG723_40905"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_supfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="SSF50998"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PJN06107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="566" mass="59958" checksum="1C92966B01E5BD06" modified="2018-04-25" version="1">MNAQTWARPAAGREPAAAALLAWLTDPQAPRLCLVTGSKRCGKSQLLAWLIGHGTRPGTTLERRVHSFVPLSGQTARTAAWAIAEHLSIAARTPGELIQTLAADPRRTVIVLPDFHAADGPDGLTELILALLELDHVRLIVETRSGHPQARTLATCSPAQMDLDEAQWTDSVRYAAWTAEHPDDIPDEHEAPRAHPNVDLNDPSAFCTADPWSVSALYEHSHDLHGGLRAAWLRAGQSLTREQDHADRALVLRAALGDDADPRHAQSLAELHAGSTWELAWTRVRGDIRPPWPGPARALAAGRGQRAGTILVADHMGTVRAVNEADAAALGRLPQAKAQPRAIASWPDGTVLVLDNHGHLHCHKATQPASTGLHALFDDQPTPLDHLVQAASDHLKDTPGTAMTATGQTIAVADASGAVHAFLPSAETPVPRTSRLHDGTVTALTAVELTDADGQPSSALLYSGGADGHVRAWRTDTAPLASPIISRPCAVTSLSAAHTPCGLVLAVSWADALVEHHAFDAGALRRFVPGLPVQAVTLTAAGHLVIGTDQALICLRPTSDKPQQLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-09-29" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JHJ9</accession>
    <name>A0A2M9JHJ9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CG723_39540</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CB01635</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000031">
        <property type="protein sequence ID" value="PJN06358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN06358">
        <property type="protein sequence ID" value="PJN06358"/>
        <property type="gene ID" value="CG723_39540"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="31"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="73"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="101"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="185"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="257"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="290"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="331"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="396"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="420"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="7">
        <location>
            <begin position="35"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PJN06358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="451" mass="48129" checksum="8CADBE38A2A7A538" modified="2018-04-25" version="1">MTTRSVTESEAPAAPPGTSLPARPRGRGNNVRWGIAVLCFGGLAVNYLDRSTLSVALPSMSDDLHIGPETQGFILSAFFVTYALCQLPAGALLDKYGVKRVFAIGAIWWSVATVGMGLVRGVGSLVGARMLLGAGEAAGYPAPAKAVSRWFPRHERTLANSVWDNGARVGTAIALPLVTMLVSVFHWRVAFIACGLLGFLWIIGWWRLYHEPADHPKLTAEERAYIEAGGAHTDETPAHEADAPKVRWRDLFRYRTVWGMMLGFFCLNYVIYFFITWFPSYLVDERGFDLLKLGFFGTVPGLVAIFGSLLGGFTADRLLRKGWSTTRVRKTCLVSGTLCSSVIALTVVVPTASGALALLSLSYASLTFSTASVASLPADVAPTAGHVASLAGIQNFASNVAGILGPIVTGFLLASSGGSYLVPLLVSGALSVVGALTYAFVIKRVEPLPVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JHR9</accession>
    <name>A0A2M9JHR9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">SAM-dependent methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_39745</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000031">
        <property type="protein sequence ID" value="PJN06393.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN06393">
        <property type="protein sequence ID" value="PJN06393"/>
        <property type="gene ID" value="CG723_39745"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransf_11" evidence="1">
        <location>
            <begin position="46"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN06393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="199" mass="21237" checksum="7203D66E05D90CA7" modified="2018-04-25" version="1">MSDDHTHVQEFFSARAAHWDTRFPDDGPRFEAAVTELGLRAGDRVLDAGCGTGRALPALRGAVGPSGAVLGVDLTPAMLEAAVRAGRDRAGSLMLADVTRLPVRSESLDAVFGSGLVAHLPQPQENLRELARVVRPGGLLALFHPIGRAALAARQGRELTPGDLRAEPNLRSLLAGSGWQMTSYVDEDDRFLALAERRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-09-29" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JHV6</accession>
    <name>A0A2M9JHV6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Alpha-mannosidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CG723_39185</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CB01635</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 38 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000030">
        <property type="protein sequence ID" value="PJN06432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN06432">
        <property type="protein sequence ID" value="PJN06432"/>
        <property type="gene ID" value="CG723_39185"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004559">
        <property type="term" value="F:alpha-mannosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006013">
        <property type="term" value="P:mannose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018905">
        <property type="entry name" value="A-galactase_NEW3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015341">
        <property type="entry name" value="Glyco_hydro_38_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037094">
        <property type="entry name" value="Glyco_hydro_38_cen_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000602">
        <property type="entry name" value="Glyco_hydro_38_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027291">
        <property type="entry name" value="Glyco_hydro_38_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028995">
        <property type="entry name" value="Glyco_hydro_57/38_cen_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09261">
        <property type="entry name" value="Alpha-mann_mid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01074">
        <property type="entry name" value="Glyco_hydro_38N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10633">
        <property type="entry name" value="NPCBM_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00872">
        <property type="entry name" value="Alpha-mann_mid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="SSF74650"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88688">
        <property type="entry name" value="SSF88688"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="SSF88713"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Alpha-mann_mid" evidence="7">
        <location>
            <begin position="404"/>
            <end position="475"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PJN06432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="1362" mass="147096" checksum="EDF9B52CEEBCA0CA" modified="2018-04-25" version="1">MRIIGVEPTDLFVGPADNPLQVVRVALDEPAPVVVTGPGAHGETTAGEPGRPVEIGVRCDAAPGAVVPLTVTAGDQVAHAELTVAEPGWTVWMVPHFHYDPVWWNTQAAYTTTWDDAGDTAQQFRIGWQYTGFELMRLHLRTARRDPDYKFVLAEVDYLKPYWDAHPEDRALLRRLLAEGRVELMGGTYNEPNTNLTSAESTVRNLVYGIGFQRGVMGGDPQTAWQLDVFGHDPQFPGLAADAGLTSSSWARGPHHQWGPMLTDRDREQDGWGDPSTMQFPAEFEWLSPSGRGVLTHYMPAHYSAGWWMDSATSLADAEDAVLELYRLMRNVAATRNLLLPVGTDYTPPNRWVTEIHRDFAARYTWPRLKCALPSEFFAAVRGELTEPSPQTRDMNPVYTGKDVSFIDTKQAQRAAESLLTEAETFATLASVETGADYPHARIDKAWRQLAYGAHHDAITGSESDQVYLDLLTSWREAYDTGRDVLDVSLRRLGPAAEDTVTVFNPSAWPRTDLVRIRLTHPETGFHGWELTDGTPLVLEHASHHEDGSLAEADVVFLAADVPSLGYRAFRLRPSRTASNWTPSDGATRIANSTHILEVDPQRGGCVSRLTVEGRELLQAGRVGNELLVYEEYPAHPRYHEGPWHLVPNGTVTGSASAPAASVRTETSALGERITVTGTVGPVRYTQTLTLWHGVDRLDGVTHVDAFDGADRLLRLRWPVRVPGALPVSEVANAVIGRGFGLIDVDSAEHPWTLDNPANNWFALSSTARVRLAEGDRALGIAEIVTPDGAGAKDLAVALVQAGVTSTCSAAPGARYGDLAVDSNLPDVRIAIGGPDENPFTAEVLTGEYADAFAAQLAATGRARLWVPADSPLEKVWVPGADLRAAHALPVLVVAGEGAVDDLVADLDDATIEVADSGPLTEPPLDDYTVALVNQGVPGFAVDSGGALHLSLMRSCTGWPSGVWIDPPRRTHPDGSTFQQQHWTHSFDYTLTAGPGDWRAQNVVPRAHDVNHPLRAVRGERAGQPETRSFLAVEPAGQVVLSALKPTGNPLSEGELPGLVPGLTMRLYEATGRQVQARLVTDLPLTGARRATLLERPEAPLAALTVDLGGMDIATVVAPLAEGRGGVEPGREPDQPVFTRYWLHNTGPAPTGNLPVAVHLHPQVLRGAGDLTVTVASGLTGASIGGEVQVLLPEGWSADTVTVPYALEPGGHLAHELRITPPPSAEPGTYWLRARTTYDGQTFEDVTRVQIGEAPPAEPVATLRTTALRLAPGEAGTLDVHLASDARTPVHVQAQLISPWQTFDLFPGWNTGAEVPARGEYTLSFPVSVPAGTRPGRWWAVVKLAAAGHLHYTEAVEIEVTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JI11</accession>
    <name>A0A2M9JI11_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HTH luxR-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_38880</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000029">
        <property type="protein sequence ID" value="PJN06508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN06508">
        <property type="protein sequence ID" value="PJN06508"/>
        <property type="gene ID" value="CG723_38880"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH luxR-type" evidence="2">
        <location>
            <begin position="274"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00421"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN06508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="350" mass="37791" checksum="5FF7E8BF732950FA" modified="2018-04-25" version="1">MPEVPGLADASLLTLLGLGPEEDAVYRLLVDRPDSDPAALAGPGAVPDDIVRALGLLVERGLASAEHRDGTVRYRAAPPVLALGPLLESRRAALHRVESLVGDLAERHRSAQSYVPVEVLSGTVAIRRRLLAMQRQARHEVCSFVPAMPVPQVLTFQDNLEEAEREAMDRGVTLRAVVERGCLEQPDTARTLADVVAHGQQISVVEDLPIKMVLVDRRAALLPLDPERDEVEPVALVVHRSGLLTGLQSLFEQHFAKGRRLGAHGAEGPGDGGGRELDAIDRQIVGLLHTGLTDAAIARQLGMGHRTVQRRLHALMDEVGAVTRFQLGWHAARAGWLDEENANSVPPQAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JID4</accession>
    <name>A0A2M9JID4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Xylan 1,4-beta-xylosidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CG723_37795</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CB01635</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 39 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000027">
        <property type="protein sequence ID" value="PJN06641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN06641">
        <property type="protein sequence ID" value="PJN06641"/>
        <property type="gene ID" value="CG723_37795"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000514">
        <property type="entry name" value="Glyco_hydro_39"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01229">
        <property type="entry name" value="Glyco_hydro_39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014670472" evidence="6">
        <location>
            <begin position="42"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="39"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="4">
        <location>
            <position position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008875"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR600514-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PJN06641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="474" mass="52458" checksum="BA6EDD62289B4517" modified="2018-04-25" version="1">MGRHGWVSGAGRWRLTALLGVGVAALALVLTVISTLPNDRADDRGTTSAGDKVHGSPSDPPAQLGPAVGWGFTHTQYSADEGDDGATRRVEDRLSGQSVPQIQHIMGWGAGNPEPVKGRYDFDEMDRRIDFIRKSGGTPVVTLCCSPDWMKGGKEGVDNTDWSQQSLETAPDRAHFKDFAALAATVAKRYPDVRHFIVWNEFKGFWNNGKQRWDYEGYTELYNLVYKALKKVDKDIMVGGPYLVMDSVDPRQTENASADVKGPWGSMDQRVLDAFDYWNKNKAGADFVVVDGSSYTVDDELLPDEFKATDKLTAVGKWVERQTGDLPLWWAEYYVEPGDRNDDRKGWSEPHRVAVQASGLVAMAKGGASSGFYWNPEEKTGTTCAGCLWTPTQSGDGGAKLPMYDLISRFHKAFPPGTEYETVPVAADDVPNVRVLADDRTVVVVNTLNRKISAQVDGKRFEMGAYELKWLERK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JIG8</accession>
    <name>A0A2M9JIG8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_37800</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000027">
        <property type="protein sequence ID" value="PJN06642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN06642">
        <property type="protein sequence ID" value="PJN06642"/>
        <property type="gene ID" value="CG723_37800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="57"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="91"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="125"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="158"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="189"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="219"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="269"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="296"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="342"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="375"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="402"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="428"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="631"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="668"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="697"/>
            <end position="716"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="776"/>
            <end position="792"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="827"/>
            <end position="844"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="865"/>
            <end position="881"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="887"/>
            <end position="903"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="910"/>
            <end position="930"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="967"/>
            <end position="986"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="998"/>
            <end position="1016"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1022"/>
            <end position="1044"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1056"/>
            <end position="1077"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1231"/>
            <end position="1251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1272"/>
            <end position="1292"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="461"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="547"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="570"/>
            <end position="605"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN06642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="1295" mass="138533" checksum="6DC4E6A2383961CB" modified="2018-04-25" version="1">MSDTTTAQAATTTPSTEPQPPAGRKLRLPGMGKGGKGNKEAMGSGGGNQLFRNAYALMLNTGISGVLGVGFWLAAAHYYTADAVGQGSAAIAAMKFLAGLTAVTLTGALARFIPIAGRATGRFIFRTYAGSSVAVSFAALVFLLTLDVWGPSYRFLHGPVNGLGFIAAVVAWSLLTLQDGVLTGLRSALWVPVGNTVFSTVKLGLLVAFAVAVPTTGVFVSWVVAIATSVVPLGWLVFRRLVPRHIKATGGKADPPTLRQMGRFLAGDYTGSLFSLAVVYLVPVLIASQVSSADNAYFYITTTIGGTVNLLAINMGASLTVEGSHDPAQLAANTRAALRRMARIMLPVCGLLFLAAPLVLHIFGDDYAHAATPLLRWFAVGAALRVVMETYFAVLRAQSRTAGLAWLQGLLCVLVLGLTLLLLPRMGLTGAGVAEISSLAVIVALAAPKLYRIVRTAPPAPPTVVPAPDGDLADLGTPDVTTGARRQGPGQALRGTLDSDTLHLAVQLNLDHQERRPDVRPGPATPAHGTPAAGGGEDEMGHRPTWALKSPPPPAPRPPAEPEPEPKPATVSATSETSATSEASATSGIVGTSSTSGTDGTSDTAVLAPPATDAPAARTLRDRLALLSPRVVVLALLLVAALGLYWGPVLGLGDGDLDGMGGLGLISVLPPATLLGAALLIGVFASLLWLEHPHKWLLLLTLLATVVSLHALPAVIEAEPRFATAWQHLGFMEYIDRTGSAVPDLDARWSWPGFFAVATFFARACGVTDMTEVIRWWPLAMQLLYLAPMFLLTRSMRASWRARWTGLWIFVLSGWVGQDYFSPQGFTYLLYLAFVAILLVWFRAPRVLWTKRRPGELEVEPTDRRQRAVLLLVLIGLFAATVPAHQLTPFVMLGVLAVLVLVGRSELRGLPILFAVLVAVWVSFLAEPYWSGHFDELFGGLGGVGGNVSSSVSGRIQGGSSAHKLVLYARVLLAGGVMAFACWGWWRRRDAKYRERSLLVLTFVPFLGFGMQSYGGEMALRVFMFALPGAALLAGLALFPRTGITAKERDRDRVSLAPLAALMAGLILMGGFLVARWGNEPFERIRPGEVAAMDYVYAHDDPTVRLLWMSNDTVDNVTPAMPWGTRDMEKVQYVPTLAPVDPVLVSGLVKALKDAGPNSYLVINKSQVVYLQMDVGYSKTWETRLIRNLDDRQELTKVLVNDDVTMYTLRKQPSGEVPKAEPGPIGPQITWTPWSVVGGLAAVALVLLLGAREIVRVAVRPGVRQLRWLQSSFWFSLPLLAVLLASILQRFLTMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JIP2</accession>
    <name>A0A2M9JIP2_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Cyclic dehypoxanthine futalosine synthase</fullName>
            <shortName evidence="6">Cyclic DHFL synthase</shortName>
            <ecNumber evidence="6">1.21.98.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Dehypoxanthine futalosine cyclase</fullName>
            <shortName evidence="6">DHFL cyclase</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Menaquinone biosynthetic enzyme MqnC</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6 8" type="primary">mqnC</name>
        <name evidence="8" type="ORF">CG723_37375</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CB01635</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Radical SAM enzyme that catalyzes the cyclization of dehypoxanthine futalosine (DHFL) into cyclic dehypoxanthine futalosine (CDHFL), a step in the biosynthesis of menaquinone (MK, vitamin K2).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>dehypoxanthine futalosine + S-adenosyl-L-methionine = 5'-deoxyadenosine + cyclic dehypoxanthinylfutalosinate + H(+) + L-methionine</text>
            <dbReference type="Rhea" id="RHEA:33083"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17319"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:58864"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:64270"/>
            <dbReference type="EC" id="1.21.98.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="6">Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.</text>
    </comment>
    <comment type="pathway">
        <text evidence="6">Quinol/quinone metabolism; menaquinone biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the radical SAM superfamily. MqnC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.21.98.1" evidence="6"/>
    <dbReference type="EMBL" id="NNBL01000026">
        <property type="protein sequence ID" value="PJN06755.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN06755">
        <property type="protein sequence ID" value="PJN06755"/>
        <property type="gene ID" value="CG723_37375"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00079"/>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046992">
        <property type="term" value="F:oxidoreductase activity, acting on X-H and Y-H to form an X-Y bond"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016765">
        <property type="term" value="F:transferase activity, transferring alkyl or aryl (other than methyl) groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009234">
        <property type="term" value="P:menaquinone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00992">
        <property type="entry name" value="MqnC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045567">
        <property type="entry name" value="CofH/MnqC-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022431">
        <property type="entry name" value="Cyclic_DHFL_synthase_mqnC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034405">
        <property type="entry name" value="F420"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020050">
        <property type="entry name" value="FO_synthase_su2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43076">
        <property type="entry name" value="PTHR43076"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19288">
        <property type="entry name" value="CofH_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00343">
        <property type="entry name" value="aminofutalosine_synthase_(mqnE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03699">
        <property type="entry name" value="menaquin_MqnC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00423">
        <property type="entry name" value="TIGR00423"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 6" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="4 6" id="KW-0408">Iron</keyword>
    <keyword evidence="5 6" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="6" id="KW-0474">Menaquinone biosynthesis</keyword>
    <keyword evidence="3 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="domain" description="Radical SAM core" evidence="7">
        <location>
            <begin position="56"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="70"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="74"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="77"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PJN06755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="399" mass="44093" checksum="2FADA87FD22661AF" modified="2018-04-25" version="1">MTEKADLQTVLDRAAAGGRITPEEALDLYRDAPLHALGAAADAIRRRRYAGTEHIATYIIERNINYTNVCVTACKFCAFYAAPKDTAKGWTRDLDDILRRCAETVELGGTQIMFQGGHHPDYGVEYYEKHFSAIKQAYPQLVIHSLGASEVEHMARISKVSVEEAIERIHAAGLDSFAGAGAELLPARPRKAIAPLKESGERWLEIMEAAHRLGVESTSTMLMGTGETNAERIEHLSMIRDVQDRTGGFRAFIPYTYQPENNHLKGRTQATLFEYLRMIAIARIFLDNVAHIQGSWLTTGKEVGQLSLHYGADDLGSIMLEENVVSSAGAKHRSNRLEIIDLIRKAGRVPAQRATTYEHLVVHDDPANDPVDDRVQSHISSTAIEGGTAHPELKLVSTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JJA4</accession>
    <name>A0A2M9JJA4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CG723_36255</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000024">
        <property type="protein sequence ID" value="PJN06949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN06949">
        <property type="protein sequence ID" value="PJN06949"/>
        <property type="gene ID" value="CG723_36255"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="SSF48371"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PJN06949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="223" mass="24049" checksum="31379722CF7CACE0" modified="2018-04-25" version="1">MTITTQDTDAIRALQGLEDGRSSVRLRAALAAGTTPDPHFIDKLIERCAIEPEFFVRDMLTWALTRHPVSMTLPKLLREVRSERVQARSQALHTLSKIGDRQAWPAITRTLLSDADDEVARSAWRAAVVLVPEGEGAALATVLATQLGRGGRETQLSLSRALVALGEVIAPALLAATTAPDPGIRAHALATQRVLRDPDTGFESAIEEAKRVVALGRPGQEGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JJT7</accession>
    <name>A0A2M9JJT7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cysteine hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_36010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000023">
        <property type="protein sequence ID" value="PJN07130.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN07130">
        <property type="protein sequence ID" value="PJN07130"/>
        <property type="gene ID" value="CG723_36010"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.850">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000868">
        <property type="entry name" value="Isochorismatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036380">
        <property type="entry name" value="Isochorismatase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00857">
        <property type="entry name" value="Isochorismatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52499">
        <property type="entry name" value="SSF52499"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Isochorismatase" evidence="1">
        <location>
            <begin position="8"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN07130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="198" mass="21133" checksum="926144784957F766" modified="2018-04-25" version="1">MEIADNAALIVVDVQKGFEEEGFWGPRNNPAADENIASLIDAWQSTGRPVVFVRHDSPKPQSPLRPGYAGNGFKEYVEGRRGKGDGAELLVTKSVNSAFYGTPDLDAWLRAAGIGQLVVAGIQTNMCAETTARMGGNLGYEVLFALDATHTFDLEGPFGWHRTAEELAQASAVSLHGGGFARVVTTTEVVAWAGALRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JJV0</accession>
    <name>A0A2M9JJV0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">AraC family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_35870</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000023">
        <property type="protein sequence ID" value="PJN07143.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN07143">
        <property type="protein sequence ID" value="PJN07143"/>
        <property type="gene ID" value="CG723_35870"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020449">
        <property type="entry name" value="Tscrpt_reg_HTH_AraC-type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00032">
        <property type="entry name" value="HTHARAC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="2">
        <location>
            <begin position="5"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="131"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN07143.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="155" mass="16753" checksum="32ECA25D1A56DB4E" modified="2018-04-25" version="1">MRQLRLAKDAMDRDWAEADLDLDAVAAHAGYSRYHFVRCFKEAYGETPGQYLTRRRIERAEEMLRTADLSVTEICGLVGFSSLGTFSSRFKRQTGLTPSEYRAKHVGRGAALIPGCYAMLWAGGFPGRGPSGGTGPGAGEERNSGEAGAGGDCLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JK00</accession>
    <name>A0A2M9JK00_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Multidrug ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CG723_34930</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000022">
        <property type="protein sequence ID" value="PJN07188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN07188">
        <property type="protein sequence ID" value="PJN07188"/>
        <property type="gene ID" value="CG723_34930"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="4"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="36"/>
            <end position="43"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PJN07188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="309" mass="32817" checksum="0F226D281136EA03" modified="2018-04-25" version="1">MTSIDVQELTKEYGTTRAVDRLTFSVGPGRVTGFLGPNGAGKSTTMRLVLGLDRPTSGTATVGGRPYRALDEPLREVGALLDAQAAHGSRTALDHLRVLAAANRIPVRRVDEVMELAGIAAVAGRRIRTFSLGMRQRLGIAAALLGDPQVVMLDEPSNGLDPEGIIWIRELMRGLAREGRTVLVSSHLMNETATFADHLVVLGRGRLLADTPMQDFIDAHSERRARVRTTDPASLHAALRSKGLEAVATGDGRWTVAGARAEEIGALAATDGIPVLELADESASLEQAYLALTADATEFASATTPLQEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JKG7</accession>
    <name>A0A2M9JKG7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Allophanate hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CG723_34515</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000021">
        <property type="protein sequence ID" value="PJN07366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN07366">
        <property type="protein sequence ID" value="PJN07366"/>
        <property type="gene ID" value="CG723_34515"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003833">
        <property type="entry name" value="CT_C_D"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010016">
        <property type="entry name" value="KipI_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34698">
        <property type="entry name" value="PTHR34698"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02682">
        <property type="entry name" value="CT_C_D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00796">
        <property type="entry name" value="AHS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="SSF50891"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AHS1" evidence="4">
        <location>
            <begin position="1"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PJN07366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="206" mass="21850" checksum="6985E43BDF126C5A" modified="2018-04-25" version="1">MRALPVGDRALLVEVSGGEEAAALHAELLRRRAAGELRVREIVPAARTVLLDGLDEPAGRLAAQLPHWELPPLPPRGDDAVHIPVRYDGPDLANVAALWGVAVEDVPRIHAAAEFRVAFCGFAPGFGYLTGLPARYDVPRRSTPRTSVPAGSVALAGPYTGVYPRSSPGGWQLLGTTDTVLWDHARVPAALLAPGTLVRFVPEVTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JL13</accession>
    <name>A0A2M9JL13_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Xaa-Pro aminopeptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_32870</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000019">
        <property type="protein sequence ID" value="PJN07564.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN07564">
        <property type="protein sequence ID" value="PJN07564"/>
        <property type="gene ID" value="CG723_32870"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036005">
        <property type="entry name" value="Creatinase/aminopeptidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000994">
        <property type="entry name" value="Pept_M24"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00557">
        <property type="entry name" value="Peptidase_M24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55920">
        <property type="entry name" value="SSF55920"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase_M24" evidence="1">
        <location>
            <begin position="15"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN07564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="280" mass="32189" checksum="5F7F6D55AF4B6283" modified="2018-04-25" version="1">MTPAVVRELSAELRGFREVQSLAYECAEAVAVQLKPGVTEREAARMQREWLRERGVRDWFHLPFAWFGDRTAFAGFRIPLQFFPTNRELEAGMPFILDMAPVYKGYTADIGYSGSLGLNPVQDKLLADLEPHRELIVREVRERRSLREIYEDVDRLMVRQGYANRHRAYPFGVIAHKVDRVKERRMSPTLFGFGTQSLKGLASDAIHGHRDGWSPLWSPYKFSDHPPQPGLWAVEPHLGFRGTGAKFEEILVVTDSKDPEQSAFWLDDDLPHVRRWAEGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JL84</accession>
    <name>A0A2M9JL84_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cobyrinic acid a,c-diamide synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_33170</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000019">
        <property type="protein sequence ID" value="PJN07618.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN07618">
        <property type="protein sequence ID" value="PJN07618"/>
        <property type="gene ID" value="CG723_33170"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025669">
        <property type="entry name" value="AAA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13614">
        <property type="entry name" value="AAA_31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA_31" evidence="2">
        <location>
            <begin position="81"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN07618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="358" mass="38137" checksum="3B52866712696D63" modified="2018-04-25" version="1">MGGSVHCEPEVEESESLRSDANIAGPMTDPVPGPRTESVGEDVSRETPPPMDDTPIGRAAQLAVEALGRAGEGLPRPEQTRVMVVANQKGGVGKTTTTVNLAASLALHGARVLVIDLDPQGNASTALGIDHHAEVPSIYDVLVESKPLSEVVQPVVDVEGLFCAPATIDLAGAEIELVSLVARESRLQRAIQAYEQPLDYILIDCPPSLGLLTVNALVAGAEVLIPIQCEYYALEGLGQLLRNVDLVRGHLNPDLHVSTILLTMYDGRTRLASQVADEVRSHFGEEVLRTSIPRSVRISEAPSYGQTVLTYDPGSSGALSYLEAAREMALRGVGIRYDAQHAHTGTQLDQHSTVEGIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-06-02" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JL85</accession>
    <name>A0A2M9JL85_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Cell division protein CrgA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">crgA</name>
        <name evidence="4" type="ORF">CG723_33305</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CB01635</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Involved in cell division.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CrgA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000019">
        <property type="protein sequence ID" value="PJN07640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN07640">
        <property type="protein sequence ID" value="PJN07640"/>
        <property type="gene ID" value="CG723_33305"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007049">
        <property type="term" value="P:cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00631">
        <property type="entry name" value="CrgA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009619">
        <property type="entry name" value="CrgA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06781">
        <property type="entry name" value="CrgA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3" id="KW-0132">Cell division</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="31"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="65"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PJN07640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="85" mass="9325" checksum="18B483F653F032E3" modified="2018-04-25" version="1">MPKSRIRKKADYTPPPASKQTANIKLTNRGWVAPVMLAMFLIGLAWIVVFYVTDGTLPLDALGNWNIVVGFGFIAAGFGVSTQWK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JLB4</accession>
    <name>A0A2M9JLB4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Rhomboid family intramembrane serine protease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CG723_33300</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CB01635</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000019">
        <property type="protein sequence ID" value="PJN07670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN07670">
        <property type="protein sequence ID" value="PJN07670"/>
        <property type="gene ID" value="CG723_33300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022764">
        <property type="entry name" value="Peptidase_S54_rhomboid_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035952">
        <property type="entry name" value="Rhomboid-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01694">
        <property type="entry name" value="Rhomboid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144091">
        <property type="entry name" value="SSF144091"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="86"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="147"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="174"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="198"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="223"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="247"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="272"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="domain" description="Rhomboid" evidence="7">
        <location>
            <begin position="130"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PJN07670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="297" mass="31708" checksum="FCB27425CA812AA1" modified="2018-04-25" version="1">MDQVPGSPQSPQDAQGTPRCYRHPDRETGIRCARCDKPICPDCMVSASVGFQCPDCVRGGSDTGHGPAASRPRTITGGTIAADPRLVTKILIGINVAVFIAVHVWDRLLSDFVLIGAWPPAPFVPDQGVAGGEWYRLVTAMFTHQEVWHIAFNMLGLWWLGGPLEAALGRARYIALYMVSGLAGSALTYAIAGPSEQSLGASGAVFGLMGATAVLVRRLNYDMRPVIGLLALNLLFTFTWGNIAWQAHVGGLVAGVVVGYAMVHAPRERRSLVQYGTCALVLAVVVVTVLVRTSQLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JLN6</accession>
    <name>A0A2M9JLN6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CG723_32495</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CB01635</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GPN-loop GTPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000018">
        <property type="protein sequence ID" value="PJN07786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN07786">
        <property type="protein sequence ID" value="PJN07786"/>
        <property type="gene ID" value="CG723_32495"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004130">
        <property type="entry name" value="Gpn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03029">
        <property type="entry name" value="ATP_bind_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PJN07786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="210" mass="23054" checksum="53A14B2720DF025E" modified="2018-04-25" version="1">MDFKSSDTLRDGPRMPGPRSEDHLPDTVSAAVKVVIVGGFGVGKTTMVGSVSEIRPLTTEETMTQAGIGVDDNYGSETKTATTVAMDFGRISITDELVLYLFGTPGQERFWFLWNGLFEGALGAVVLIDTRRLEVSFDVIGRLEERGVPFVIANNAFPDGPRYPADELRQALDLDPDVPILECDARRRASSRDVLMTLMSYLHELALARV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JM51</accession>
    <name>A0A2M9JM51_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_31695</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000017">
        <property type="protein sequence ID" value="PJN07956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN07956">
        <property type="protein sequence ID" value="PJN07956"/>
        <property type="gene ID" value="CG723_31695"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="2">
        <location>
            <begin position="66"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN07956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="198" mass="21599" checksum="75D02DC30E00CAFB" modified="2018-04-25" version="1">MQHATERLQLDAAAAAARAGAGYPQVGAACGISRQGARRRWPGLFDHPDEKPTERPMMTTPARPFDVLLVEDDIADAMLIQEALSGRGARNLVQVSDGVAALEHLRRPGNPRPDLIVLDLNMPRMNGRDLLKVLKNDEDLHTIPVVVLSTSTAPDDVTDAYSSHANAYVTKPVNLDEFEQAVQSIDAFYLDTAARPRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JMJ3</accession>
    <name>A0A2M9JMJ3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Alpha-glucosidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CG723_30450</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CB01635</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 13 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000016">
        <property type="protein sequence ID" value="PJN08017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08017">
        <property type="protein sequence ID" value="PJN08017"/>
        <property type="gene ID" value="CG723_30450"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.400.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022567">
        <property type="entry name" value="DUF3459"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006047">
        <property type="entry name" value="Glyco_hydro_13_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045857">
        <property type="entry name" value="O16G_dom_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00128">
        <property type="entry name" value="Alpha-amylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11941">
        <property type="entry name" value="DUF3459"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00642">
        <property type="entry name" value="Aamy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aamy" evidence="3">
        <location>
            <begin position="11"/>
            <end position="393"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PJN08017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="540" mass="59520" checksum="BA1B08FCB7B6508C" modified="2018-04-25" version="1">MSWWQDTVCYEVYPRAFADSDGDGIGDLPGLTERLEHIKDLGADAVWCTPFYPSPLADGGYDIADYTGVASDLGTDDDVTQLISRAHELGLRFIIDLVPNHTSDQHPWFQEALAAGPGSAEREMYLFRPGRGADGELPPNDWQSAFGGPAWTRVADGEWYCHLHAAEQPDLNWRNPKVQSAFTEVLRHWLDHGVDGFRVDVAHALFKAEGLPDAGPGQHTDPLRNHLMPYYDQEELHPLYREWRALLDTHPAPAGAAAPQDRVMVAESAVFDPARLSRYIRPDEMHQAFNFAFLEAPWEAAELRRVVDGSFAVPGSAVTWLLSSHDAVRPVTRHGSLARARAAALLMLALPGSAYLFQGEELGLPQADVPIDRILDPLWERSGRTERGRDGARVPLPWTGEHAPYGFSTVAPDRTWLPQPDDWSGLTVAAQQRDPDSTLALYRAALRIRRTHPAPDPTAPPTWLSAPDAPYLAFRRGALVCLVNLGAEPLRLTSLGLPGRATLRSGPFDGDTLPPDTALWLLDPTAPAHLAESDTDDTRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JMV5</accession>
    <name>A0A2M9JMV5_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Transglut_core2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_29725</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0162 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000015">
        <property type="protein sequence ID" value="PJN08185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08185">
        <property type="protein sequence ID" value="PJN08185"/>
        <property type="gene ID" value="CG723_29725"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032698">
        <property type="entry name" value="SirB1_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13369">
        <property type="entry name" value="Transglut_core2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transglut_core2" evidence="2">
        <location>
            <begin position="49"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13369"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN08185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="280" mass="30024" checksum="B940D1686A2E26F3" modified="2018-04-25" version="1">MSPHISPRSEELRRRFAEEARAERPDLSQLCLLVAAEADGSLDEAGMDAVQMDLDRLAGQVPFRPGGPRAWATALAELLGSRCGFRGTPGDYERLESSLLHEVVRRRRGLPILLSVVWMEVARRAGAPVYGVALPGHFVVGFGPAQDQVLADPFDGGQVLTGADAELLVAGATGAPLNASMLQPADPLDVVLRILNNIRAWAATRPERSDVAMWAVELSLLLPTHPARLRYERAQLLVRSGDFLAGAAELDAYAEVVGAVDAPAAETVRAQARAARAMLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JMX6</accession>
    <name>A0A2M9JMX6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CG723_29855</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000015">
        <property type="protein sequence ID" value="PJN08209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08209">
        <property type="protein sequence ID" value="PJN08209"/>
        <property type="gene ID" value="CG723_29855"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PJN08209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="212" mass="22188" checksum="46FD801E986261AC" modified="2018-04-25" version="1">MRGEPSCPKCGGRVRAPGLFSDSWQCDVHGAVHPLQPVIPPSVEALTVVAHRAQVPVWMPWPLPVGWLFTGVVSAGDDRTGGRATAVACSGPGPLGGVGEMLLVAEELGVGLGARYAGVDGPDPGPYMTVEKPPEAKVLAAGRPTPMWHVSGAPDDRAVFAGEACGLWVWAIVWPEQTGLLMYDELVLTDLRDVGAEVDLVPCGALSPRILT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JNA5</accession>
    <name>A0A2M9JNA5_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Recombination protein RecR</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">recR</name>
        <name evidence="9" type="ORF">CG723_28550</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CB01635</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the RecR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000014">
        <property type="protein sequence ID" value="PJN08340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08340">
        <property type="protein sequence ID" value="PJN08340"/>
        <property type="gene ID" value="CG723_28550"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01025">
        <property type="entry name" value="TOPRIM_recR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00017">
        <property type="entry name" value="RecR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000093">
        <property type="entry name" value="DNA_Rcmb_RecR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000445">
        <property type="entry name" value="HhH_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023627">
        <property type="entry name" value="Rcmb_RecR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023628">
        <property type="entry name" value="Rcmb_RecR_C4-type_Zn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015967">
        <property type="entry name" value="Rcmb_RecR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006171">
        <property type="entry name" value="TOPRIM_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034137">
        <property type="entry name" value="TOPRIM_RecR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30446">
        <property type="entry name" value="PTHR30446"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00633">
        <property type="entry name" value="HHH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02132">
        <property type="entry name" value="RecR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13662">
        <property type="entry name" value="Toprim_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00493">
        <property type="entry name" value="TOPRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111304">
        <property type="entry name" value="SSF111304"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00615">
        <property type="entry name" value="recR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01300">
        <property type="entry name" value="RECR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50880">
        <property type="entry name" value="TOPRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7" id="KW-0227">DNA damage</keyword>
    <keyword evidence="5 7" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="6 7" id="KW-0234">DNA repair</keyword>
    <keyword evidence="1 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Toprim" evidence="8">
        <location>
            <begin position="79"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C4-type" evidence="7">
        <location>
            <begin position="56"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PJN08340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="199" mass="21794" checksum="049AAD8B7446436D" modified="2018-04-25" version="1">MYEGVVQDLIDELGRLPGVGPKSAQRIAFHILQAEPTDVRRLAQALMEVKAKVRFCATCGNVAQEELCNICRDPRRDLTVICVVEEPKDVVAVERTREFRGKYHVLGGAISPIEGVGPDDLRIRELLARLADGTVTELILATDPNLEGEATATYLARMIKPMGLKVTRLASGLPVGGDLEYADEVTLGRAFEGRRLLDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JNC2</accession>
    <name>A0A2M9JNC2_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5">Kynureninase</fullName>
            <ecNumber evidence="4 5">3.7.1.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">L-kynurenine hydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4 7" type="primary">kynU</name>
        <name evidence="7" type="ORF">CG723_28665</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CB01635</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4 5">Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3-hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3-hydroxyanthranilic acid (3-OHAA), respectively.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>3-hydroxy-L-kynurenine + H2O = 3-hydroxyanthranilate + H(+) + L-alanine</text>
            <dbReference type="Rhea" id="RHEA:25143"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:36559"/>
            <dbReference type="ChEBI" id="CHEBI:57972"/>
            <dbReference type="ChEBI" id="CHEBI:58125"/>
            <dbReference type="EC" id="3.7.1.3"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4 5">
            <text>H2O + L-kynurenine = anthranilate + H(+) + L-alanine</text>
            <dbReference type="Rhea" id="RHEA:16813"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16567"/>
            <dbReference type="ChEBI" id="CHEBI:57959"/>
            <dbReference type="ChEBI" id="CHEBI:57972"/>
            <dbReference type="EC" id="3.7.1.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4 5">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4 5">Amino-acid degradation; L-kynurenine degradation; L-alanine and anthranilate from L-kynurenine: step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4 5">Cofactor biosynthesis; NAD(+) biosynthesis; quinolinate from L-kynurenine: step 2/3.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4 5">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 5">Belongs to the kynureninase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.7.1.3" evidence="4 5"/>
    <dbReference type="EMBL" id="NNBL01000014">
        <property type="protein sequence ID" value="PJN08360.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08360">
        <property type="protein sequence ID" value="PJN08360"/>
        <property type="gene ID" value="CG723_28665"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00253">
        <property type="reaction ID" value="UER00329"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00334">
        <property type="reaction ID" value="UER00455"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061981">
        <property type="term" value="F:3-hydroxykynureninase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030429">
        <property type="term" value="F:kynureninase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034354">
        <property type="term" value="P:'de novo' NAD biosynthetic process from tryptophan"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043420">
        <property type="term" value="P:anthranilate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097053">
        <property type="term" value="P:L-kynurenine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019805">
        <property type="term" value="P:quinolinate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006569">
        <property type="term" value="P:tryptophan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01970">
        <property type="entry name" value="Kynureninase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000192">
        <property type="entry name" value="Aminotrans_V_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010111">
        <property type="entry name" value="Kynureninase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14084">
        <property type="entry name" value="PTHR14084"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00266">
        <property type="entry name" value="Aminotran_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038800">
        <property type="entry name" value="KYNU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01814">
        <property type="entry name" value="kynureninase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 4 5" id="KW-0662">Pyridine nucleotide biosynthesis</keyword>
    <keyword evidence="3 4 5" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminotran_5" evidence="6">
        <location>
            <begin position="37"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="region of interest" description="Pyridoxal phosphate binding" evidence="4">
        <location>
            <begin position="132"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="103"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="104"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="201"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="204"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="226"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="256"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="282"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="4">
        <location>
            <position position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR038800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PJN08360.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="404" mass="42663" checksum="A16710114C3D4BCC" modified="2018-04-25" version="1">MSDVTALAGKALELDAADELGKLRERFVLDDTGDSVYLDGNSLGALPAQVPGRVEDVVRRQWGELRIRSWTESGWWTAPERIGDRIAPLVGAAEGQIVVGDSTSVNVFKALVGAVRLAGEGRDEILVDATTFPTDGYIAESAARMTGCTLRPLTPAEVPGALGDRTAAVLLNHVDYRTGRLHDLPALTAAVRAAGAVSVWDLCHSAGALPVGLDRHGVDLAVGCTYKYLNGGPGSPAYLYVRSDLQSRFDSPLPGWNSHTEPFGMRPSYEAGDGAVRGRVGTPDILSMLALEAALDVWDGVSVDAVRAKSLALTDFFLECVEAYVPAGRVESVTPAAHAERGSQVALRADDAGAVMERLIAVGVVGDFRAPDVLRFGFTPLYLGFAEVERAARVLADQLAAAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JNG3</accession>
    <name>A0A2M9JNG3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CG723_28930</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000014">
        <property type="protein sequence ID" value="PJN08405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08405">
        <property type="protein sequence ID" value="PJN08405"/>
        <property type="gene ID" value="CG723_28930"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PJN08405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="114" mass="13049" checksum="9509D36DEC91F9E2" modified="2018-04-25" version="1">MVERSPAAQSLRRSYVTADGCRFDVIEMSVEHHADRSATLTYWLTVGCPGHPDEHWVVALPWGDKSWADVLTSPASPPPDRLRQLVHLVRAHLEEWWDTKGHNRRSARMGRRIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-09-29" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JNL8</accession>
    <name>A0A2M9JNL8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Phenylacetic acid degradation protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CG723_29320</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000014">
        <property type="protein sequence ID" value="PJN08472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08472">
        <property type="protein sequence ID" value="PJN08472"/>
        <property type="gene ID" value="CG723_29320"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00207">
        <property type="entry name" value="fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036010">
        <property type="entry name" value="2Fe-2S_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001041">
        <property type="entry name" value="2Fe-2S_ferredoxin-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006058">
        <property type="entry name" value="2Fe2S_fd_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008333">
        <property type="entry name" value="Cbr1-like_FAD-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001433">
        <property type="entry name" value="OxRdtase_FAD/NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00970">
        <property type="entry name" value="FAD_binding_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00111">
        <property type="entry name" value="Fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00175">
        <property type="entry name" value="NAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="SSF52343"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54292">
        <property type="entry name" value="SSF54292"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="SSF63380"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00197">
        <property type="entry name" value="2FE2S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51085">
        <property type="entry name" value="2FE2S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding FR-type" evidence="6">
        <location>
            <begin position="2"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="domain" description="2Fe-2S ferredoxin-type" evidence="5">
        <location>
            <begin position="263"/>
            <end position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PJN08472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="352" mass="38395" checksum="02E13C37B7542890" modified="2018-04-25" version="1">MARFHQLRVAAVDRLTDDSVALTLEVPESLREEFRHAPGQHLALRRPADDGEIRRTYSICSPAPGPEGPRTLRVGVRLVEGGSFSTYALKEIAVGDALEVMTPAGRFILEPTPGLYAAVVGGSGITPVLSIAATLLAREPHARFCLIRSDRTAASTMFLDEVADLKDRYPDRFQLVMVLSREEQQAGLDSGRLDQERLTTLLPALLPVDDIAGWYLCGPFGLVQEAERTLRALGVRRARIHEEIFHVDDGAAPARPAPTLAHSTVTAQLDGRSGTWPVDDGESLLETVLRNRPDAPYACKGGVCGTCRAFLVSGEVRMDRNFALEPEETDAGYVLACQSHPATETVELDFDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JNQ8</accession>
    <name>A0A2M9JNQ8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">AsnC family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CG723_29265</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000014">
        <property type="protein sequence ID" value="PJN08506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08506">
        <property type="protein sequence ID" value="PJN08506"/>
        <property type="gene ID" value="CG723_29265"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000485">
        <property type="entry name" value="AsnC-type_HTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019888">
        <property type="entry name" value="Tscrpt_reg_AsnC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019887">
        <property type="entry name" value="Tscrpt_reg_AsnC/Lrp_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01037">
        <property type="entry name" value="AsnC_trans_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00033">
        <property type="entry name" value="HTHASNC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00344">
        <property type="entry name" value="HTH_ASNC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50956">
        <property type="entry name" value="HTH_ASNC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH asnC-type" evidence="4">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PJN08506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="145" mass="16404" checksum="89E44AC3F6BB6031" modified="2018-04-25" version="1">MDAIDRDILQMLQMDGRASIRSVAERVHVSRANAYARINRLIDDGVIRGFGARVNHERAGQGASAYITLKIVQNSWRTVREQLRRLPEASHIALVSGDFDVLLMVHTQDNRALRELVLTKLQAMPEVLSTRTLLVFEEEDLEPDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JP01</accession>
    <name>A0A2M9JP01_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Carbohydrate kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_27990</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000013">
        <property type="protein sequence ID" value="PJN08602.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08602">
        <property type="protein sequence ID" value="PJN08602"/>
        <property type="gene ID" value="CG723_27990"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016773">
        <property type="term" value="F:phosphotransferase activity, alcohol group as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018484">
        <property type="entry name" value="Carb_kinase_FGGY_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00370">
        <property type="entry name" value="FGGY_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="FGGY_N" evidence="1">
        <location>
            <begin position="3"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN08602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="460" mass="49661" checksum="60B9FEC664287FA1" modified="2018-04-25" version="1">MWFLGIDIGTTHIKVAGVDADGTPLPAGRIRTPTLAVDKLTFHDAEVIWHATAELIAEYARTTAAPHGPLGGAAVASFGQEESVAVDEVGRMLYPSLAWWERRPVRALDAETARWLDSFEQFQVSGLRHRLDQTPERTAHLRVREPQLWRSTARWVDFCTFITHRMTGEWVSATNQITHSQCFELATLAPHAPVMERLGLTPAHFAPALPTGADAGDMLPTALPGVAIARGARVVIGGHDQVVAARQVHSMSGAEVFDSIGTSEYLMVGTGTFAPRMRSYELGLDHERAWHDDGFLLGCPIPSGKVVQLLAELFHHGDFDRLFSDLAATPSGGLPSLHVTVGSTGEAPEEAEGLLTLTGLPAGARPSEVVRGTLDHLADLARTAIGEMCELAGRQPGQVALMGSLFRRPEMAAHRRERWDLPLHISPMAEPVASGAAAIARDALTSTSSPRRDHDGKETS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JPK2</accession>
    <name>A0A2M9JPK2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Xanthine dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_26890</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000012">
        <property type="protein sequence ID" value="PJN08717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08717">
        <property type="protein sequence ID" value="PJN08717"/>
        <property type="gene ID" value="CG723_26890"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000674">
        <property type="entry name" value="Ald_Oxase/Xan_DH_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036856">
        <property type="entry name" value="Ald_Oxase/Xan_DH_a/b_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016208">
        <property type="entry name" value="Ald_Oxase/xanthine_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008274">
        <property type="entry name" value="AldOxase/xan_DH_Mopterin-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037165">
        <property type="entry name" value="AldOxase/xan_DH_Mopterin-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11908">
        <property type="entry name" value="PTHR11908"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01315">
        <property type="entry name" value="Ald_Xan_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02738">
        <property type="entry name" value="Ald_Xan_dh_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01008">
        <property type="entry name" value="Ald_Xan_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54665">
        <property type="entry name" value="SSF54665"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56003">
        <property type="entry name" value="SSF56003"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ald_Xan_dh_C" evidence="1">
        <location>
            <begin position="16"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM01008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN08717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="742" mass="79343" checksum="6AF36A7AE194C525" modified="2018-04-25" version="1">MIGQALNRVDGPLKVAGQATYAYEQWGAGQPLYGFIVGATIGKGRITRIDTESAERAPGVKMVMTYHNAPAQGIRDESIPFEYWRAQPVLTGPDIHYYGEPVAFVVATALEQARAAAGLVEVEYADAHGRFNFAEQEDEVYIPKVVNAGLPTDTAVGDFDAGFDSAAVKLDQEYTTPYELSMPMEPHACLAEPRDEDLVVYVSCQIVDAARASVAATLRLDPERVHIVTPFVGGGFGSKLGIHSETILAALAARELRRPVKAAMTRQQIFQLVGNRPTTSQRVRLGAERDGRLTAIAHDVTMHTNPDVEYAEQTAATTRSLYAAPHRLTSHRLAPLDLPPGTDVRAPGEAPGMLAVESAMDELAHALGMNPVELRILNEPTVDPERDVPYSDRHLVECLREGARRFGWEHRPATPASVRDGRWLVGYGMSAAIRGHFQGPTAVRVRLEADGTAVVQTDMTDLGTGTYTVLTQVAAEGLGLPPDRVRIELGRSDFPTSWGSGGSWGAASSCNAVHGACMTLREQLLAAARGDTRSPLHGLDPADAVFSDGNVAIGGASEALSEIVARNRPEGFEAEGGTRFMGDDPNYTDYSINTYGAHFAEVGVDADTAEIRLRRMLGVFSVGRVLNAKTARSQLIGGMIWGAGAALEEEAVVDLRSGAFVNRDFAQYLVPVHADVPDVDAVVLDGYDDKANVLGAKGVGELGICGAGASIANAVFNATGVRVRDFPITIEKVLPGLPLMDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JPU2</accession>
    <name>A0A2M9JPU2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Protein-tyrosine-phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_25690</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000011">
        <property type="protein sequence ID" value="PJN08888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08888">
        <property type="protein sequence ID" value="PJN08888"/>
        <property type="gene ID" value="CG723_25690"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023485">
        <property type="entry name" value="Ptyr_pPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036196">
        <property type="entry name" value="Ptyr_pPase_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01451">
        <property type="entry name" value="LMWPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00226">
        <property type="entry name" value="LMWPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52788">
        <property type="entry name" value="SSF52788"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LMWPc" evidence="1">
        <location>
            <begin position="16"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN08888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="213" mass="22641" checksum="960809141428E9ED" modified="2018-04-25" version="1">MTAPETGRGIGNGDSFRILHVSTGNVCRSPITERLTRHALVDRLGDPLVRGLIVESAGTWGHEGAPMEANAETVLADFGADASGFVGRELLDDHVIRADLVLTATRDHRAQVISMGHSAGLRTFTLKEFTRLVQAIDPATLPDPLDGGVVERARALVRAAAALRGWLLAPNAEADEVYDPYGAPLPFFRSVGEEISEALEPVVTALTGVPACK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JQE3</accession>
    <name>A0A2M9JQE3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_24510</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000010">
        <property type="protein sequence ID" value="PJN09088.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN09088">
        <property type="protein sequence ID" value="PJN09088"/>
        <property type="gene ID" value="CG723_24510"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN09088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="60" mass="6764" checksum="E0EE758CE69F2DFE" modified="2018-04-25" version="1">MVIIQLLSTLVVLGFEQLVQWRYGAFGLFALILLTTGIRMRSERWLTVGAVLLVLLTMQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JQS4</accession>
    <name>A0A2M9JQS4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Type VI secretion protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_24180</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000010">
        <property type="protein sequence ID" value="PJN09226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN09226">
        <property type="protein sequence ID" value="PJN09226"/>
        <property type="gene ID" value="CG723_24180"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="71"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="106"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN09226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="488" mass="51700" checksum="F8D7BDF652BCCD6F" modified="2018-04-25" version="1">MLLGVLAFLLGMTVMVWTATGLSGLFSKGAWPDGVTIRHTPVAMRSLIGRPHDLPGAWPDTPDGQLSGYGLFWGLFIGQVLVLIVLAVFVAGTVARWRAVRRRGRAETAAAPPAEPAPAVTPAPRATVSEVVPAAGAEPPDRHAHVQHDQRPVHDQHREHLEHLASPVTPAAAPMAVPAPRGPVVLGPAETRAPRAIQAIRDAEGPVLVVTSSASVWAETKDARSKLGPVLVYDPTHLCDTPARLHWNPAQGCEDKPTAASRAAALLAPIRPAAKLDMATADTAETLLRSFLHAAAVDAKPFRHVHRWAQGSQVQEAVRILRTSPKAAAGAAGELEAALTSHLERRDIAQELTARALSSLFSVHIREACTPNRTDALTLDSFVNEGGTLYVVGEAIEDPKADPGAMPLLTALASSVVEHGRRMAERSSAGRLDPPMALVLDDVAAVAPLPQLPELLSTGADRGLPTLALLRSREQGRARWPHADLPAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JQZ5</accession>
    <name>A0A2M9JQZ5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ABC transporter substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_23440</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000009">
        <property type="protein sequence ID" value="PJN09306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN09306">
        <property type="protein sequence ID" value="PJN09306"/>
        <property type="gene ID" value="CG723_23440"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006059">
        <property type="entry name" value="SBP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13416">
        <property type="entry name" value="SBP_bac_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014883507" evidence="1">
        <location>
            <begin position="30"/>
            <end position="407"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN09306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="407" mass="42531" checksum="66090B1D28BCA2B3" modified="2018-04-25" version="1">MHPRPRAAVAACAALALSAVLGGCGLITADTPANTLTVADYYTAEPGNTALTSILDTCAADTGVDVVREVMPRAQLVPKLLRDGAARTLPDLILSDNPDLPKLASTGALLPLDGRLDTDGFYDSVLAAGTYKGTLYGVAPGVNGLALFYDKAAFREAGLEPPTDWKQLRAAASELTRGHRYGLALSAVGTEEGSWQYEPFLWGAGADLDDLDSPRSVSALSYWTSLFADGSVSKSALNWQQSDVAEQFIGHHAAMMVNGSWQLAALDAVKGLDYGVVPLPGKVSGTSPVTPLGGETWAVPKGDKQDKAVELLDCVLGRDNMLRWASLRADVPADPAVAAKLVKRQPDLAPFLASVPGARSRTAELGTGYPTVSQALYTALQEAATGRRTPADALAAAQRAAATSDDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JS81</accession>
    <name>A0A2M9JS81_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 4">Acylphosphatase</fullName>
            <ecNumber evidence="3 4">3.6.1.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CG723_21155</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CB01635</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 4">
            <text>an acyl phosphate + H2O = a carboxylate + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:14965"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29067"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:59918"/>
            <dbReference type="EC" id="3.6.1.7"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the acylphosphatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.7" evidence="3 4"/>
    <dbReference type="EMBL" id="NNBL01000007">
        <property type="protein sequence ID" value="PJN09713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN09713">
        <property type="protein sequence ID" value="PJN09713"/>
        <property type="gene ID" value="CG723_21155"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003998">
        <property type="term" value="F:acylphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020456">
        <property type="entry name" value="Acylphosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001792">
        <property type="entry name" value="Acylphosphatase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036046">
        <property type="entry name" value="Acylphosphatase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47268">
        <property type="entry name" value="PTHR47268"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00708">
        <property type="entry name" value="Acylphosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54975">
        <property type="entry name" value="SSF54975"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51160">
        <property type="entry name" value="ACYLPHOSPHATASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acylphosphatase-like" evidence="6">
        <location>
            <begin position="6"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="active site" evidence="4">
        <location>
            <position position="21"/>
        </location>
    </feature>
    <feature type="active site" evidence="4">
        <location>
            <position position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PJN09713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="93" mass="10295" checksum="7B5796B3D4BB49AC" modified="2018-04-25" version="1">MNEDVRITAWVRGRVQRVGFRWFTRAKALEIGGLSGFALNLDDGRVQVVAEGSRASCQGLLDWLRDGDTPGRVDGVTEIWDAPRGGYADFAIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JSA1</accession>
    <name>A0A2M9JSA1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Aminotransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_21230</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000007">
        <property type="protein sequence ID" value="PJN09728.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN09728">
        <property type="protein sequence ID" value="PJN09728"/>
        <property type="gene ID" value="CG723_21230"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000192">
        <property type="entry name" value="Aminotrans_V_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00266">
        <property type="entry name" value="Aminotran_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotran_5" evidence="1">
        <location>
            <begin position="63"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN09728.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="400" mass="42424" checksum="B4EEEF95F530C464" modified="2018-04-25" version="1">MTPTHSAAPALPETFPLATIPVDEAMARQFRLIECTAAHFAGEELFSADAGVVPGLGRPRTTAKAEAVLADFFGAEDAAFVQGAGTGAIRAALNAAVSAGDPLLIHRAPVYRTTEVTLRGIGVRTEEVDFNDLGALREALASGRFRWAYVQHTRQRLGDSYDPGGVLAACRAAGVRTIVDDNYAVLRVPASGVELGADASCFSLFKLHGPEGVGIVVGARDLVERVRADNYSGGGQVQGHQALDVLRALTHVPVMWAVQSRVGAQVAERLAAGEVPGVAEVRLANAQDRCLLVRLDRPVARQLPTVAARFGAAPYPVGSNSRYEIAPLFYRMSSSSLDDSPGLADWTVRINPMRAGADLVIDILRRSLDAVHNHGLDAAQSHGLDAVQNHNAVQNHAKDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JSB8</accession>
    <name>A0A2M9JSB8_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 6 7">Elongation factor Ts</fullName>
            <shortName evidence="6">EF-Ts</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6 10" type="primary">tsf</name>
        <name evidence="10" type="ORF">CG723_21370</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CB01635</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5 6 7">Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF-Tu.GTP complex up to the GTP hydrolysis stage on the ribosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6 8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6 7">Belongs to the EF-Ts family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000007">
        <property type="protein sequence ID" value="PJN09754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN09754">
        <property type="protein sequence ID" value="PJN09754"/>
        <property type="gene ID" value="CG723_21370"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.479.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00050">
        <property type="entry name" value="EF_Ts"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036402">
        <property type="entry name" value="EF-Ts_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001816">
        <property type="entry name" value="Transl_elong_EFTs/EF1B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014039">
        <property type="entry name" value="Transl_elong_EFTs/EF1B_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018101">
        <property type="entry name" value="Transl_elong_Ts_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11741">
        <property type="entry name" value="PTHR11741"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00889">
        <property type="entry name" value="EF_TS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="SSF46934"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54713">
        <property type="entry name" value="SSF54713"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00116">
        <property type="entry name" value="tsf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01126">
        <property type="entry name" value="EF_TS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01127">
        <property type="entry name" value="EF_TS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 6 7" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="4 6 7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EF_TS" evidence="9">
        <location>
            <begin position="73"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="region of interest" description="Involved in Mg(2+) ion dislocation from EF-Tu" evidence="6">
        <location>
            <begin position="82"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00016956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00025453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PJN09754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="278" mass="29755" checksum="A8AE8634BB5DCB1B" modified="2018-04-25" version="1">MANYTAADVKKLRELTGAGMMDCKKALDEADGSVDKAVEALRIKGQKGVAKREGRSAENGAVVSLIADDNTSGVILELKCETDFVAKGEKFQAVANSLAAHAAKTNPADIAALLASEIEPGKTVQAYVDEANANLGEKIVLDRFAQFSGAYVTAYMHRTMPDLPPQIGVLVELDKADADLAKGIAQHIAAFAPKYLSREDVPAEVVESERRVAEETTRAEGKPEAALPKIVEGRVNGFFKEATLLGQPYALDNKKSVQKVLDEAGVTLKRFSRIKVGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JSD4</accession>
    <name>A0A2M9JSD4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_21645</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000007">
        <property type="protein sequence ID" value="PJN09801.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN09801">
        <property type="protein sequence ID" value="PJN09801"/>
        <property type="gene ID" value="CG723_21645"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00279">
        <property type="entry name" value="YlxR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007393">
        <property type="entry name" value="DUF448"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037465">
        <property type="entry name" value="YlxR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035931">
        <property type="entry name" value="YlxR-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34215">
        <property type="entry name" value="PTHR34215"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04296">
        <property type="entry name" value="YlxR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64376">
        <property type="entry name" value="SSF64376"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YlxR" evidence="1">
        <location>
            <begin position="13"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN09801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="92" mass="10225" checksum="AA6FB33EEFC5FC5E" modified="2018-04-25" version="1">MSGRTHARACPERTCVGCRERTAKSDLLRIVVIEGECVPDQRGTLPGRGAYVHPALVCLDLAVRRRAFQRAFKAPGPFDTEALRHRVEQVTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JSU1</accession>
    <name>A0A2M9JSU1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_19735</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000006">
        <property type="protein sequence ID" value="PJN09961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN09961">
        <property type="protein sequence ID" value="PJN09961"/>
        <property type="gene ID" value="CG723_19735"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021385">
        <property type="entry name" value="DUF3017"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11222">
        <property type="entry name" value="DUF3017"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="61"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="85"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="115"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN09961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="155" mass="16179" checksum="61FF1EB1738E1E93" modified="2018-04-25" version="1">MSADAGTGTPEGAEGAVSAPGADGKPRRASRRFPLFTRDTARPEGGGRAAPGDAPAPARQWPILAVISLVGVGLLLTAFDVFRVGTLLIGVALIGGAVLRWTLPSVGMLAVRSRFTDMVTYGFLGVVIVLLALMVQPSPWLVIPFLNDTLHFTIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JT49</accession>
    <name>A0A2M9JT49_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CG723_19715</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CB01635</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 3">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GMC oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000006">
        <property type="protein sequence ID" value="PJN09957.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN09957">
        <property type="protein sequence ID" value="PJN09957"/>
        <property type="gene ID" value="CG723_19715"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012132">
        <property type="entry name" value="GMC_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000172">
        <property type="entry name" value="GMC_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007867">
        <property type="entry name" value="GMC_OxRtase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552">
        <property type="entry name" value="PTHR11552"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05199">
        <property type="entry name" value="GMC_oxred_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00732">
        <property type="entry name" value="GMC_oxred_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000137">
        <property type="entry name" value="Alcohol_oxidase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00624">
        <property type="entry name" value="GMC_OXRED_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GMC_OxRdtase_N" evidence="4">
        <location>
            <begin position="252"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="87"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000137-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS00624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PJN09957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="512" mass="55957" checksum="94D7712A837E8E65" modified="2018-04-25" version="1">MPEKSVNTYDYVVVGGGTAGSVIASRLTQNPDVTVAVIEGGPSDIDRDDVLTLRRWLGLLGGDLDYGYTTTEQPRGNSHILHSRAKVLGGCSSHNTLISFKPLPGDWDEWAAAGAEGWDHKAMDPYFGKLRNNIVAVDEKDRNAIARDFVDAAQTATGVPRVDGFNKAPFKDGVGFFDLAYHPENNKRSSASVAYLHPHMEAGDRPNLTLLLETWAYRLEMDGTRARGVHVRTKDGEELLVEARHEVVVCAGAVDTPRLLMHSGIGPKADLEKLGIPVLHDLPGVGENLLDHPESVIVWETDGPIPDNSAMDSDAGLFVQRDPEASGPDLMFHFYQIPFTDNPERLGYVRPEHGVSMTPNIPKPRSRGRLYLTSADPAEKPALDFRYFTDEEDYDGRTLVDGIRIAREIAKTEPLAGWLKREVCPGPDVVGDEELGEYARKVAHTVYHPAGTCRMGARNDELAVVDPELRIRGLEAIRIADASVFPTMPAVNPMIGVLMVGEKCAELLGGDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-06-02" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JT59</accession>
    <name>A0A2M9JT59_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Bifunctional purine biosynthesis protein PurH</fullName>
        </recommendedName>
        <domain>
            <recommendedName>
                <fullName evidence="8">Phosphoribosylaminoimidazolecarboxamide formyltransferase</fullName>
                <ecNumber evidence="8">2.1.2.3</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="8">AICAR transformylase</fullName>
            </alternativeName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="8">IMP cyclohydrolase</fullName>
                <ecNumber evidence="8">3.5.4.10</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="8">ATIC</fullName>
            </alternativeName>
            <alternativeName>
                <fullName evidence="8">IMP synthase</fullName>
            </alternativeName>
            <alternativeName>
                <fullName evidence="8">Inosinicase</fullName>
            </alternativeName>
        </domain>
    </protein>
    <gene>
        <name evidence="8" type="primary">purH</name>
        <name evidence="10" type="ORF">CG723_19765</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CB01635</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>(6S)-10-formyltetrahydrofolate + 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide = (6S)-5,6,7,8-tetrahydrofolate + 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide</text>
            <dbReference type="Rhea" id="RHEA:22192"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="ChEBI" id="CHEBI:57454"/>
            <dbReference type="ChEBI" id="CHEBI:58467"/>
            <dbReference type="ChEBI" id="CHEBI:58475"/>
            <dbReference type="EC" id="2.1.2.3"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>H2O + IMP = 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide</text>
            <dbReference type="Rhea" id="RHEA:18445"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
            <dbReference type="ChEBI" id="CHEBI:58467"/>
            <dbReference type="EC" id="3.5.4.10"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 8">Purine metabolism; IMP biosynthesis via de novo pathway; 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide (10-formyl THF route): step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 8">Purine metabolism; IMP biosynthesis via de novo pathway; IMP from 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide: step 1/1.</text>
    </comment>
    <comment type="domain">
        <text evidence="8">The IMP cyclohydrolase activity resides in the N-terminal region.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the PurH family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.2.3" evidence="8"/>
    <dbReference type="EC" id="3.5.4.10" evidence="8"/>
    <dbReference type="EMBL" id="NNBL01000006">
        <property type="protein sequence ID" value="PJN09967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN09967">
        <property type="protein sequence ID" value="PJN09967"/>
        <property type="gene ID" value="CG723_19765"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00133"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003937">
        <property type="term" value="F:IMP cyclohydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004643">
        <property type="term" value="F:phosphoribosylaminoimidazolecarboxamide formyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1380">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00139">
        <property type="entry name" value="PurH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024051">
        <property type="entry name" value="AICAR_Tfase_dup_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016193">
        <property type="entry name" value="Cytidine_deaminase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011607">
        <property type="entry name" value="MGS-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036914">
        <property type="entry name" value="MGS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002695">
        <property type="entry name" value="PurH-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11692">
        <property type="entry name" value="PTHR11692"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01808">
        <property type="entry name" value="AICARFT_IMPCHas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02142">
        <property type="entry name" value="MGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000414">
        <property type="entry name" value="AICARFT_IMPCHas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00798">
        <property type="entry name" value="AICARFT_IMPCHas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00851">
        <property type="entry name" value="MGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52335">
        <property type="entry name" value="SSF52335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53927">
        <property type="entry name" value="SSF53927"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00355">
        <property type="entry name" value="purH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51855">
        <property type="entry name" value="MGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 8" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="5 8" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="MGS-like" evidence="9">
        <location>
            <begin position="1"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51855"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PJN09967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="520" mass="55137" checksum="5FF71FEADAC1237E" modified="2018-04-25" version="1">MTAESNKRPIRRALVSVYDKTGLEDLARGLHEAGVELVSTGSTAAKIAAAGVPVTKVEELTGFPECLDGRVKTLHPKIHAGILADLRLEDHQRQLAELGVEPFQLVVVNLYPFKETVASGATPDECVEQIDIGGPSMVRAAAKNHPSVAVVTSPARYADVLSAVRDGGFDLTARKRLAGEAFQHTAAYDVAVASWFADGYAAADESGLPEFLGATYGRKNVLRYGENPHQAAALYVDGTGGLAEAEQLHGKEMSYNNYTDTDAARRAAYDHDDPCVAIIKHANPCGIAVASSVAEAHRKAHACDPMSAFGGVIAVNRPVTKEMAEQVADIFTEVIVAPEYEDGALEALTKKKNIRVLRAHQGPSAVVETKQIDGGALLQVTDRVQADGDNPASWTLATGDALSPGELDELAFAWKACRAVKSNAILLAKDGASVGVGMGQVNRVDSCKLAVERAGEERARGSFAASDAFFPFPDGPQILIDAGVKAIVQPGGSIRDEQVVEAAKKAGVTMYFTGTRHFFH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JT72</accession>
    <name>A0A2M9JT72_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">PIG-L family deacetylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_20395</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000006">
        <property type="protein sequence ID" value="PJN10074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN10074">
        <property type="protein sequence ID" value="PJN10074"/>
        <property type="gene ID" value="CG723_20395"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016137">
        <property type="term" value="P:glycoside metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10320">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003737">
        <property type="entry name" value="GlcNAc_PI_deacetylase-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024078">
        <property type="entry name" value="LmbE-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12993">
        <property type="entry name" value="PTHR12993"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02585">
        <property type="entry name" value="PIG-L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102588">
        <property type="entry name" value="SSF102588"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="47"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN10074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="686" mass="72640" checksum="7BD5037DA54E69EF" modified="2018-04-25" version="1">MGYKSARSEAGEGRIGGTRRLPGRRAILLGSAAVAAATATAAITARMEQTPPPPHPTAPSPASGRPAAEGEHALLLQVLAHPDDDLYFMNPDTSQAFAAGVPLVCVYVTAGEADGVNRIPGRPHPPADKSGYAAARHQGLRQSYATQLGLPVFSGWRTEVTTLAGGHQAEVNTLEHRGRRVELVFLDLAMHTPAGHMGAPALWRESDLPLRTVVVDGSPLRRAQMYDYDGLVDVLVGLFERYRPTLVHTLDPDPDIQDSDLRTRIRDSEQPGFSDHADHTAVAAFTWAALIRWSQTAAGGPPPFAATAFRGYYNHHWPENLPGAVLHAKAAHLMPYGAAPDWQCGNPSGCGDYNVGGDRPLTNRKGWVRSTHYRYPGPRIALAQEPDGKLSGYGVLGMRAVRWRETTQGVFGRPTDLGGGPLAPALGSATLRDGRQLLLGLRLAALEGRGGSDLREVVVLEQRAPGGEFGAWTGLGNPEADPVRGRRIGVPVAVTARDGQVHLFVRDADQGISTRVRGLDGRWSPWRGLGGGPVQDGLTAVVGEDGGVHVYAPGRDTVHHWTPEGPAPLAGLPVPADAVASAGGRLYYRAPASSALTATAGPPVDFPGYGPVTADGPYLLGRDTGGTLQVLYRGRTRRAARDLVTLDGPALRATPRGPVAAGLSPAARPWLWRPDSSTGTGTARKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JTH2</accession>
    <name>A0A2M9JTH2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MarR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_17325</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000005">
        <property type="protein sequence ID" value="PJN10169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN10169">
        <property type="protein sequence ID" value="PJN10169"/>
        <property type="gene ID" value="CG723_17325"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000835">
        <property type="entry name" value="HTH_MarR-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12802">
        <property type="entry name" value="MarR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00598">
        <property type="entry name" value="HTHMARR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00347">
        <property type="entry name" value="HTH_MARR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50995">
        <property type="entry name" value="HTH_MARR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH marR-type" evidence="1">
        <location>
            <begin position="17"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN10169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="157" mass="17314" checksum="CDCAED5C7D7C0D48" modified="2018-04-25" version="1">MHNALMDKRVMEVDPRAEGLMIAVEQMVRYVRQSAVAGGLSTAASSAIGRLGREGPYRLSELARAEGVSQPNMTQLVTRMERAGLVRRVADHNDGRAVLVEATESGLEVFRQRRAERTQALDLLIGELTEPEQQAVRTALPALARAIQDRQTRTAHD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-06-02" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JTJ6</accession>
    <name>A0A2M9JTJ6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_20615</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000006">
        <property type="protein sequence ID" value="PJN10107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN10107">
        <property type="protein sequence ID" value="PJN10107"/>
        <property type="gene ID" value="CG723_20615"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="41"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="135"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="96"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="136"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN10107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="159" mass="16242" checksum="D48123E51428296E" modified="2018-04-25" version="1">MPGVPDVPPPKGHTAPPAPPAVWVPPPPPWPLFVLSPPSSPVFPASPPVASGLRKLRVKPLPPPPPPPATMRRGSEAGTPVRVQPGPAELQVRTSLEPPPAPPVTIPDPPPAPPPVPTLTKRVVVLTGTVTVPVTVAPLPPAPPLGPFWPAAPVAETVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JTV3</accession>
    <name>A0A2M9JTV3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glyoxalase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_18205</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000005">
        <property type="protein sequence ID" value="PJN10316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN10316">
        <property type="protein sequence ID" value="PJN10316"/>
        <property type="gene ID" value="CG723_18205"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004360">
        <property type="entry name" value="Glyas_Fos-R_dOase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00903">
        <property type="entry name" value="Glyoxalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VOC" evidence="1">
        <location>
            <begin position="9"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN10316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="143" mass="16171" checksum="24268EF0F2EB9F49" modified="2018-04-25" version="1">MTELDWPIPRFHLAMPVDDLPAARHFYGEVLGLEQGRSADTWVDWNLHGHQFVTHLAPTRAEHIRNPVDGHDVPVPHFGLILTIPAFQELADRLRAADTKFVIEPYVRFAGEPGEQWTMFLLDPAGNALEFKAFADDSQVFAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-09-29" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JTX7</accession>
    <name>A0A2M9JTX7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CG723_18395</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000005">
        <property type="protein sequence ID" value="PJN10346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN10346">
        <property type="protein sequence ID" value="PJN10346"/>
        <property type="gene ID" value="CG723_18395"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.620.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025859">
        <property type="entry name" value="AurF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009078">
        <property type="entry name" value="Ferritin-like_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012348">
        <property type="entry name" value="RNR-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11583">
        <property type="entry name" value="AurF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47240">
        <property type="entry name" value="SSF47240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PJN10346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="304" mass="34641" checksum="6A58BA663A973AE6" modified="2018-04-25" version="1">MASSTVRPESHELHDERGVSQRLLESAAVLAYDPATEVDWETPLDKDFHGASPEWSTLYGTAYWAELTEEQRKELTRQEAASVASTGIWFEMILQQMVLRDMYAKDPTKADFQWALTEVAEECRHSIMFARGAQKLGAPAYRPHRFVIELGRVFKTLAFGETAYVAILVAEEVLDVMQRDWMRDERVVPFVRTINNIHVVEESRHMKFARDQTRKRLAGAGRLRRHINAFLVATASYFIVTSMVRRQVYESAGLDVKRAVAEAGANEHHKSMMRASCSGLMEFLASARLLTRPALAFYKRANLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JUD0</accession>
    <name>A0A2M9JUD0_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA helicase</fullName>
            <ecNumber evidence="2">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CG723_17780</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CB01635</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O = ADP + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="2"/>
    <dbReference type="EMBL" id="NNBL01000005">
        <property type="protein sequence ID" value="PJN10484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN10484">
        <property type="protein sequence ID" value="PJN10484"/>
        <property type="gene ID" value="CG723_17780"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000212">
        <property type="entry name" value="DNA_helicase_UvrD/REP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014016">
        <property type="entry name" value="UvrD-like_ATP-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11070">
        <property type="entry name" value="PTHR11070"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51198">
        <property type="entry name" value="UVRD_HELICASE_ATP_BIND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0347">Helicase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UvrD-like helicase ATP-binding" evidence="6">
        <location>
            <begin position="195"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="216"/>
            <end position="223"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PJN10484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="736" mass="80732" checksum="99127E0047BB2ADD" modified="2018-04-25" version="1">MTSTTTSAFDLPERLSSKADATLIAGDEQHFAAIASSLDQTITELSDRLDVLRKAPGGIGREAMDRDSEIHRLTGRLRALRRFGLDLCLGRVVGADDAEPLYIGRLGLTDSEGRRLLVDWRSPAAEPFFAATHANPMRLASRRRYRWTGGRISDYWDEVFTADGLEQRAALDDQSAFIASLGSNRSARMRDVLGTIQADQDAIIRAGSRGALVVDGGPGTGKTVVALHRSAYLLYSDPRLSHRRGGVLFVGPHRPYLDYVADVLPSLGEEGVQTCILQDLVAEGVTAEVETDPDVARLKSSAAMVQAIEKAVRFYEEPPTKGMTATTAWSDIWVSADDWAEAFKAPGPGAAHNEAREQVWEELATILMDKQGMDEDEDEDEDGVSPDLFLRSLRQDRDLVAALNSAWPLLEAADLVSDLWTVPAYLRMCAPWLDRDDVAKLQRKDAPQAWTVSDLPLLDAARQRLGDPEAARRKRRHDAAVAAERERMALVIDDIISAADFNSAGDDSEGAVRMLRGKDLQDSLIDESALPTADPDRLAGPFAHIVVDEAQELTDAEWQMLLLRCPSRSFTIVGDRAQARHGFTESWEERLERAGLDRIKLASLSINYRTPEEVMTEAEPVIRAELPDANVPTSIRSSGVPVVHGPVTDLDSILDTWLAAHDDGIACVIGDPTFRATSRVRSLTPELSKGLEFDLVVLIDPEEFGDGIEGAVDRYVAMTRTTQQLVILTSSFLTSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JUF3</accession>
    <name>A0A2M9JUF3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CG723_18940</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000005">
        <property type="protein sequence ID" value="PJN10515.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN10515">
        <property type="protein sequence ID" value="PJN10515"/>
        <property type="gene ID" value="CG723_18940"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PJN10515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="164" mass="17754" checksum="DE81FEBE25DFB4F3" modified="2018-04-25" version="1">MVITLPMANPLLEAAAEVNPALVRKGLPAHVSLLYPFLPAAELTADVDAGVRDLAASLPAVETDLKDFVVAPRFVAVPVPALQAVADAFCARWPHIAPYGGRFGERPEPHVTLATGATDEEAELVRDRVRPLLPLRVAAWRVDLVVRTDRDWRLRLTAPFAASP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JUH3</accession>
    <name>A0A2M9JUH3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CG723_15025</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CB01635</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Nitrate/nitrite porter (TC 2.A.1.8) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000004">
        <property type="protein sequence ID" value="PJN10535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN10535">
        <property type="protein sequence ID" value="PJN10535"/>
        <property type="gene ID" value="CG723_15025"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015112">
        <property type="term" value="F:nitrate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042128">
        <property type="term" value="P:nitrate assimilation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd17341">
        <property type="entry name" value="MFS_NRT2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044772">
        <property type="entry name" value="NO3_transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23515">
        <property type="entry name" value="PTHR23515"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0534">Nitrate assimilation</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="31"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="67"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="96"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="121"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="160"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="188"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="229"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="266"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="296"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="320"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="375"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="405"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="8">
        <location>
            <begin position="29"/>
            <end position="429"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PJN10535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="450" mass="47373" checksum="D6FD63FD2A33F1F6" modified="2018-04-25" version="1">MAARSWIQRWDPEDETFWSREGGEKVARRNLAFSILSEHIGFSIWTLWSVMVLFMGPEYGIDPAGKFFLVSMATMVGAVARVPYTFAVARFGGRNWTILAASLLLIPTAAAFVVMEPGTSYTTFMVCALLTGVGGGNFASSMTNINSFFPLRKKGWALGLNAGGGNIGVPVVQLAGLAVIGASGGPRVLLGIYLPLIAVSAICAALFMDNLATVKNDTGAAKEAVRDPHTWIMSFLYIGTFGSFIGYSFAFGLVLQTQFGRTPLQAASITFIGPLLGSLIRPVGGRLADRFGGARITLWNFVAMAAATAVVVLASTQKSLPLFTTAFIALFVLTGLGNGSTYKMIPGIFQAKAAARGLAGEEAAAYGRRLSGASMGLIGAVGALGGLGINLAFRQSFQTAGTGTAAFVGFLVFYAVCFALTWAVYLRRPAGADAPVQAAEPEPRLSYAEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-09-29" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JUH8</accession>
    <name>A0A2M9JUH8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_15110</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000004">
        <property type="protein sequence ID" value="PJN10551.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN10551">
        <property type="protein sequence ID" value="PJN10551"/>
        <property type="gene ID" value="CG723_15110"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.43.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036683">
        <property type="entry name" value="CO_DH_flav_C_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016167">
        <property type="entry name" value="FAD-bd_PCMH_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002346">
        <property type="entry name" value="Mopterin_DH_FAD-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00941">
        <property type="entry name" value="FAD_binding_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55447">
        <property type="entry name" value="SSF55447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="SSF56176"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="1">
        <location>
            <begin position="1"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN10551.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="294" mass="29844" checksum="75387B78BB23A70D" modified="2018-04-25" version="1">MTTHATQAVTLPGSLDEAVAALSAMPAAVPVAGGTDLMASVNAGLLRPAALVGLGRISEIRGWQYQDGHALLGAGLTHARIGRPDFAALIPALAAAARAAGPPQIRNAGTLGGNIASAAATGDTLPVLAALEATLIIAGPGGVRREVPVSHLLAGMEMLSPGELIGFVRVPLLHAPQTFLKATGRTGPGRALASVALVLDPARRGVRCAVGAIAPMPLRPLEAEQWVASLIDWDGERMLVPEALAAFGEYVAAACIPDAAPAPDGTQEQLPPAVLHLRRTVAALARRALGRALS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-09-29" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JUQ2</accession>
    <name>A0A2M9JUQ2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Thioredoxin-dependent thiol peroxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_15415</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000004">
        <property type="protein sequence ID" value="PJN10604.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN10604">
        <property type="protein sequence ID" value="PJN10604"/>
        <property type="gene ID" value="CG723_15415"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004601">
        <property type="term" value="F:peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000866">
        <property type="entry name" value="AhpC/TSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00578">
        <property type="entry name" value="AhpC-TSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="1">
        <location>
            <begin position="5"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN10604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="155" mass="16710" checksum="6315B3D5440A1FD4" modified="2018-04-25" version="1">MSERLTTGDTAPAFTLPDADGKEVSLADHKGRKTIVYFYPAALTPGCTKQACDFTDNLDVLAGAGYDVIGISPDKPEKLAKFREKENLKVTLLGDPSKETLEAYGAYGEKKLYGKTVTGVIRSTIVVDEDGKVERALYNVKATGHVAKIIKDLGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JUS7</accession>
    <name>A0A2M9JUS7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_15590</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000004">
        <property type="protein sequence ID" value="PJN10635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN10635">
        <property type="protein sequence ID" value="PJN10635"/>
        <property type="gene ID" value="CG723_15590"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01381">
        <property type="entry name" value="HTH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="2">
        <location>
            <begin position="11"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="339"/>
            <end position="358"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN10635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="717" mass="77475" checksum="534ACBF4637E0D06" modified="2018-04-25" version="1">METGEEFGPWLARQLKFAGKSQAELADELKLTRAAVSAWITGRSTPRPTVMTDIARALGTDIGTVHTRTTDTQSGLPVTWYHRPGYPDGGRDLGNAAAFAFDADVQVLARETCQNSLDERLRENGRPVRVRYTLHELTGDALDDFRDAILWNDLFPHYSAVSDASGNQKVGRVVDSGVRDMYEQGRLVLLRIDDYNASGLTGDDYGDGKFAAVVRRQLESLKSGPGAGGSYGLGKATLWATSALGLVLINSTLSAAHEGRTERRVIGRLELPWREVDGAPYAGPAWLGRPDPDTPGAAVARSWWADEAEVERLHLTRESDEPGTSFLVVGAHDVASLDASTSGIDDDVDEADDEGTDPRNIERMHFRLVEALGRDFWAAMTGGGGRLPLLEVFVRTMRNGEVVVPEEQIDPSAEQPARTRALKAHYDGATVEKLTEAGQVAMRQIPLKLPLSGGARGSLGTHQGVLLLTDAEENDHGGKNQVHSLRGNRMTVKRSRVPGLPLGVNPFQAVLLLGDAAGETAAFTRESEDFLRAAEPPEHDGWGQTDELTLRWSPAAYRRINALTAEVNQAVKDLVARPKRGSTEGGAALRKALTVKAKPKAKAPSGPVVPVLDTLEAEIGDGGDWRITAQVTIPRGDEITPMAPIAQLDVRSGGRPNLRWAELEGIEGCEVVDGTLRFAPGARRATFRGATDVTSHPVRTALSRLVVELRTGKREDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JUT4</accession>
    <name>A0A2M9JUT4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="11">PTS lactose transporter subunit IIC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CG723_15380</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CB01635</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000004">
        <property type="protein sequence ID" value="PJN10598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN10598">
        <property type="protein sequence ID" value="PJN10598"/>
        <property type="gene ID" value="CG723_15380"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008982">
        <property type="term" value="F:protein-N(PI)-phosphohistidine-sugar phosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009401">
        <property type="term" value="P:phosphoenolpyruvate-dependent sugar phosphotransferase system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003352">
        <property type="entry name" value="PTS_EIIC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013013">
        <property type="entry name" value="PTS_EIIC_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02378">
        <property type="entry name" value="PTS_EIIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51103">
        <property type="entry name" value="PTS_EIIC_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0598">Phosphotransferase system</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="6 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="65"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="96"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="143"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="182"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="282"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="332"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="386"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="domain" description="PTS EIIC type-1" evidence="10">
        <location>
            <begin position="15"/>
            <end position="418"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PJN10598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="428" mass="45819" checksum="89F072E084334D1A" modified="2018-04-25" version="1">MSADSAAVYKPSPWSNLFQGLQKMGRSLQLPIAVLPAAGILNRLGQPDVFGDEGLGWTDVSKVMVGAGGALLDGALGLPLLFCIGVAIGMAKKSDGSTALAAVVGFLVYYNVLHQFPVDCGPGAKAVVTGCAGPDGTVVPFGYQNPGVFGGIVMGLLAAFFWQRFHRTKLVDWLGFFNGRRLVPIIMAFVAIAVAAICLWIWPPIGDALESFSDWLVGLDWLGAGIFGVANRALLVIGLHQFLNVPIWFQFGTYTKPDGTEVHGDINMFLAGDPNAGQFTSGFFPIMMFALPAACLAMTHCARPERRKVVGGLMLSVALTSFVTGITEPIEYSFLFVAPVLYAIHAVLTGVSMAVTWALGVHDGFSFSAGLIDYVINWSLATKPWLIIPIGLAFGVVYYAIFRFAITKFNLKTPGREPEDQVEDVTKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JUV3</accession>
    <name>A0A2M9JUV3_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">CdiI_2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_15525</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000004">
        <property type="protein sequence ID" value="PJN10622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN10622">
        <property type="protein sequence ID" value="PJN10622"/>
        <property type="gene ID" value="CG723_15525"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041129">
        <property type="entry name" value="CdiI_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18593">
        <property type="entry name" value="CdiI_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CdiI_2" evidence="1">
        <location>
            <begin position="126"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF18593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN10622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="233" mass="26140" checksum="5C955EB1C733202B" modified="2018-04-25" version="1">MPMNPLEHDRRYGELDQVMRAYVGQAADDTEDKPGAALTAYLRHTWHTRPWALADAEQQLREYSRNPPGRVRLRLGEFYPVPDVGLPEADIQDWLRILADHIKHSIEAGEVPPPSAPVTHWEWHARFPEAAQFLGGWFSQDMPDEFEDHDAATRDYITTTDLHLKARLAGELHELLALPLDESDYAQGLTELGMEVDPETPYSPSGWLARVAEQMGGGGFVADYGEGRAQGGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JVD9</accession>
    <name>A0A2M9JVD9_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Biotin transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CG723_16685</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CB01635</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the BioY family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000004">
        <property type="protein sequence ID" value="PJN10812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN10812">
        <property type="protein sequence ID" value="PJN10812"/>
        <property type="gene ID" value="CG723_16685"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015225">
        <property type="term" value="F:biotin transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003784">
        <property type="entry name" value="BioY"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34295">
        <property type="entry name" value="PTHR34295"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02632">
        <property type="entry name" value="BioY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016661">
        <property type="entry name" value="BioY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="2 3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="73"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="97"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="131"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="162"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRNR" id="PIRNR016661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PJN10812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="192" mass="18915" checksum="9DA985E0F4468F39" modified="2018-04-25" version="1">MSTAAVSTRPGKVLADLLPASRTRDIALVLGGAALTGVAAQIAVPVPGSPVPVTGQTFAALLVGTALGARRGFLSLAVYALVGMAGMPWFAQGTSGAGGASFGYVIGMLLASTVVGALARRGGDRSVLRTAGTMVLGSAIIYAVGVPYLAAATGMTLTQAVAAGLTPFLIGDAVKAALAMGVLPTAWKFADK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-05-25" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JVL4</accession>
    <name>A0A2M9JVL4_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Biotin carboxylase</fullName>
            <ecNumber evidence="2">6.3.4.14</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CG723_16055</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CB01635</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>biotin</name>
            <dbReference type="ChEBI" id="CHEBI:57586"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.14" evidence="2"/>
    <dbReference type="EMBL" id="NNBL01000004">
        <property type="protein sequence ID" value="PJN10935.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN10935">
        <property type="protein sequence ID" value="PJN10935"/>
        <property type="gene ID" value="CG723_16055"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004075">
        <property type="term" value="F:biotin carboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005481">
        <property type="entry name" value="BC-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001882">
        <property type="entry name" value="Biotin_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011764">
        <property type="entry name" value="Biotin_carboxylation_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005482">
        <property type="entry name" value="Biotin_COase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000089">
        <property type="entry name" value="Biotin_lipoyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005479">
        <property type="entry name" value="CbamoylP_synth_lsu-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011054">
        <property type="entry name" value="Rudment_hybrid_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011053">
        <property type="entry name" value="Single_hybrid_motif"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02785">
        <property type="entry name" value="Biotin_carb_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00289">
        <property type="entry name" value="Biotin_carb_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00364">
        <property type="entry name" value="Biotin_lipoyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02786">
        <property type="entry name" value="CPSase_L_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00878">
        <property type="entry name" value="Biotin_carb_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51230">
        <property type="entry name" value="SSF51230"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51246">
        <property type="entry name" value="SSF51246"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="SSF52440"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50979">
        <property type="entry name" value="BC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00188">
        <property type="entry name" value="BIOTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50968">
        <property type="entry name" value="BIOTINYL_LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00867">
        <property type="entry name" value="CPSASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0092">Biotin</keyword>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Biotin carboxylation" evidence="10">
        <location>
            <begin position="1"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-grasp" evidence="9">
        <location>
            <begin position="120"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="domain" description="Lipoyl-binding" evidence="8">
        <location>
            <begin position="556"/>
            <end position="638"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PJN10935.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="645" mass="67632" checksum="887E60E55134ACB8" modified="2018-04-25" version="1">MFDTVLVANRGEIAVRVIRTLRVLGIRSVAVYSDADADARHVREADTAVRIGPPPAGESYLRVDRLLEAAARTGAQAVHPGYGFLAENAAFARACADAGLVFIGPSADAISLMGDKIRAKETVQAAGVPVVPGSSGSGLTDAQLADAAREIGMPVLLKPSAGGGGKGMRLVRDEALLGDEIAAARREARASFGDDTLLVERWVDRPRHIEIQVLADGHGHVIHLGERECSLQRRHQKIIEEAPSVLLDEATRAAMGEAAVQAARSCGYRGAGTVEFIVPGNDPSSYYFMEMNTRLQVEHPVTELITGVDLVEWQLRVAAGEQLPYAQGDIELTGHAVEARICAEDPSRGFLPSGGTVVSLREPQGDGVRTDSGLSEGTEVGSLYDPMLSKVIAYGPDRATALRKLRAALAETVTLGVPTNAGFLRRLLAHPAVVAGELDTGLVEREADGLVSGEVPVEVYEAAAALRAARLAPSGDGWTDPFSVPSGWRLGGEPAPLDLHLRVAGLEPVTHRAQGTGTVGADSVTVHLDGLTHTFHRAGDWLGRDGDAWHVQDFDPVAASLTGAAHSGADSLTAPMPGTVTVVKVAVGDEVVAGQSLLVVEAMKMEHVISAPHAGTVAELDVTPGTTVAMDQILAVVTPHEETTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-06-02" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JVT0</accession>
    <name>A0A2M9JVT0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Asp23/Gls24 family envelope stress response protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_08350</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the asp23 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN11003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN11003">
        <property type="protein sequence ID" value="PJN11003"/>
        <property type="gene ID" value="CG723_08350"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005531">
        <property type="entry name" value="Asp23"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34297">
        <property type="entry name" value="PTHR34297"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03780">
        <property type="entry name" value="Asp23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN11003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="161" mass="16578" checksum="6ABE346B566B47AD" modified="2018-04-25" version="1">MTDTTDRPPSEQDGPTETATMLKGPTGAGTSPETRGKTTIADGVVAKIAGTAAREVPGIHNLGAGVTRAIGAVRERVPGGGTGGVSRGVKVEVGERQAAMDIDVVVEYGFSIVDVAAEVRVNVISAVERMTGLEVVEVNLVVDDVNLPDEDDAEPTEGRVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JW92</accession>
    <name>A0A2M9JW92_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Alpha-galactosidase</fullName>
            <ecNumber evidence="1">3.2.1.22</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CG723_09405</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CB01635</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal, non-reducing alpha-D-galactose residues in alpha-D-galactosides, including galactose oligosaccharides, galactomannans and galactolipids.</text>
            <dbReference type="EC" id="3.2.1.22"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.22" evidence="1"/>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN11160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN11160">
        <property type="protein sequence ID" value="PJN11160"/>
        <property type="gene ID" value="CG723_09405"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052692">
        <property type="term" value="F:raffinose alpha-galactosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016052">
        <property type="term" value="P:carbohydrate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14791">
        <property type="entry name" value="GH36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038417">
        <property type="entry name" value="Alpga-gal_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002252">
        <property type="entry name" value="Glyco_hydro_36"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031704">
        <property type="entry name" value="Glyco_hydro_36_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16875">
        <property type="entry name" value="Glyco_hydro_36N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005536">
        <property type="entry name" value="Agal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00743">
        <property type="entry name" value="GLHYDRLASE36"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glyco_hydro_36N" evidence="4">
        <location>
            <begin position="31"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="3">
        <location>
            <begin position="343"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="3">
        <location>
            <begin position="453"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="2">
        <location>
            <position position="455"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="2">
        <location>
            <position position="523"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="177"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="420"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="501"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="523"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRNR" id="PIRNR005536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR005536-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR005536-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF16875"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PJN11160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="687" mass="76529" checksum="52A5029ABB08C21C" modified="2018-04-25" version="1">MSQVYFDEPSRTFLLTTPASSYALRIGADDSPRHVHWGAPLTLEQVAALPTHDGLTSSFATTGGEELAVEGGPRFGVPSLLVRYSDGTRGVEWTYEGHEIDGGHLHVRLRDRHYPLGCTLRYAVHPDSDIVERSLTLRHLGTEEAAGEPVEILRCDAASWSVPAASGVRLSHTVGKWSGETQLRRTEAPYAETVFTSRRGVSGHYGNPWLMVDAGDADEGHGEVWSMVLAWSGSWRITAQRDHTGGPFTVTGGAGHDGLTWRLQPGESHDTPVFAGQFSRGGFGAASRGWHRYVAGHVLPRPDEPRPVVYNSWEATGWDVTLEGQRALAARAAELGVELFVVDDGWFGQRTSDRAGLGDWHPNPERFPYGLGPLVEEIRGLGMRFGLWVEPEMTNPDSDLYREHPEWVLHMPHRRRTELRQQLVLNFARTDVTEWAFKWLDRLVSTYTIDFLKWDMNRALTEAGWPGHPDAERLWTDHTRGVYSVLDRLRSAHPGLRIEGCAGGGGRADLGMLAHTDQTWISDNTDADDRIAIQHGYSQVYPARTMSAWVTDSPNPHTRRTTPLLYRFHVAMTGALGIGGDLSRWTGAELAEARDLVALYKVIRPVVQFGEQYRLDDAVQYWADDRVVVIAWGRDRDLRLTGLSPASVYVDESTGTEHTAASLLSQGLPLRLPRTDRPSTVIRLTRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JWA7</accession>
    <name>A0A2M9JWA7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Taurine dioxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CG723_09360</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN11154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN11154">
        <property type="protein sequence ID" value="PJN11154"/>
        <property type="gene ID" value="CG723_09360"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042098">
        <property type="entry name" value="TauD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003819">
        <property type="entry name" value="TauD/TfdA-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02668">
        <property type="entry name" value="TauD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TauD" evidence="3">
        <location>
            <begin position="13"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PJN11154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="274" mass="29913" checksum="E3E484E65C30F77F" modified="2018-04-25" version="1">MTAVATFDILRAGPRFGAEITGIDLTAPVDKTTADALRQAFQDHKVLVFRGQHLTPDQHVAAVRIFAEPFDHPTAAKDDANPLVYPYNVRQTGKASTWHIGGLWRDPVFAIESLTYEVVPELGGHTLWADLQAAYDDLSEPFKELLESVSAVYDGNAENYAQGSKRTASGPTVEHPVVLAHPATGRKGLFISTSAIGLTGVTPAESKVLLDHLLRHASSPNHTIRFGWQPGDFVLWDNRATWHYAVDDYGDGARVYRKVIGVEPEAGRVPGARP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JWF9</accession>
    <name>A0A2M9JWF9_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">GSDH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CG723_09905</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN11241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN11241">
        <property type="protein sequence ID" value="PJN11241"/>
        <property type="gene ID" value="CG723_09905"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012938">
        <property type="entry name" value="Glc/Sorbosone_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011041">
        <property type="entry name" value="Quinoprot_gluc/sorb_DH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07995">
        <property type="entry name" value="GSDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="SSF49899"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50952">
        <property type="entry name" value="SSF50952"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014799572" description="GSDH domain-containing protein" evidence="2">
        <location>
            <begin position="32"/>
            <end position="707"/>
        </location>
    </feature>
    <feature type="domain" description="GSDH" evidence="3">
        <location>
            <begin position="146"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="28"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PJN11241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="707" mass="76704" checksum="356E302AE47E862C" modified="2018-04-25" version="1">MAARRKNPRLWAAFAVTATLALGGLAAPSHADEPAPTAATASLTDPIPEKPAQSRTGLVLTEYAQFPTSEPVPAPTDPRLMRHARINTINELPDGSGRMATPDLNGTLYLTDPGTAGKDSGGTPHPYLDVKGTFPNFFSGRGLGQGFGYAAFHPQFAKNGRFYTIHTELASQVTQAPDFKQAGTTTYHGVITEWTADDPKAAVFHGTHREVLRIGFTGQVHGIQQIDFNPTARPHDKDYGLLYLAVGDGGQGVGNSEPQNMALPHGKLLRIDPAGRNSANGKYGIPAANPFVSTPGALGEIYAVGMRDPHRFSWDTGGSHRMYLGHIGEHAIESVYEVKAGDNFGWSEREGPFLFDKKTTDPCARIAPLPADDAKYGYTYPVAAYDHDPGADWDCRSDVGRAIAGGFVYRGKDAPELRGTYIFGDLVDGRILAADTHDMRRGAGLAPLKSLMLFDQATGKKVTMRDLAGDQRVDLRFGTDLAGDLYIVSKANGKVWKVTGTRTFADCKVGHTPTTHTTGADNWAPVTPAKWEFTRRETVLTEPGVSRPGPRRPFEYAVLTAGPRYSNVTIEAEVRIDTPVDITNRDVIVVWDYDSDTQFQYAHLSSDNSIYPHNGLFTVDNADRLRIDDQWNGTYGAPPAIKDAAWHKVRLTHCADTGETAVYMDGSRTPLITGTDPVFSSGRVGFGSFDNNGRIRNLKVTGTVARD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JWG0</accession>
    <name>A0A2M9JWG0_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Carboxylic ester hydrolase</fullName>
            <ecNumber evidence="1">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CG723_09590</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CB01635</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="1"/>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN11189.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN11189">
        <property type="protein sequence ID" value="PJN11189"/>
        <property type="gene ID" value="CG723_09590"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019826">
        <property type="entry name" value="Carboxylesterase_B_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00122">
        <property type="entry name" value="CARBOXYLESTERASE_B_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="COesterase" evidence="3">
        <location>
            <begin position="8"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="484"/>
            <end position="514"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU361235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PJN11189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="514" mass="54001" checksum="4A1B73C620A0E702" modified="2018-04-25" version="1">MTDHAAEPPVVRTAHGPVRGERRDTGVRFLGIPYAQPPVGALRFAAPVPPEPWSDVLDATAYGPTAQRRPLAEVTFIPEPSIPGDGTLNLNVFTPDLSPDAGLPVMVWIHGGGFLAGSQASPWYDGAAFNRDGVVVVSIGYRLGFDGFGWISDAPHNRTVRDWLLALEWVRDNIRGFGGDPDRVTIAGQSAGGAAVLTLLGMPRAQHLFHRVHCLSGPVSQVSTTVAERLGRKLAELGGVPPTRTGLSQLSEGQILDLQKQVSSPAADTDADADTGAGTDPDDALAGIAGLIAENLPFAPMIDGDLIPEATLDALTAGVGADKELVLGATDHEFTMALHPMRDRLATAAPARILTACGVDGTVAAAYVADHPGLDTADLVGQYVTDRLFRTAVARVARARGSAPTWLYRFAWRSPVLGLATHCLDVPFHFDCLDAEGVTAVAGAEPPKTLATDVHGAAVEFIRDGRPGWKPWISSAPTTRVFDTRSSDTGDGYADVSALLPPPQSPTTPGGSKC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JWV4</accession>
    <name>A0A2M9JWV4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Iron ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CG723_10495</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CB01635</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN11349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN11349">
        <property type="protein sequence ID" value="PJN11349"/>
        <property type="gene ID" value="CG723_10495"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037294">
        <property type="entry name" value="ABC_BtuC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000522">
        <property type="entry name" value="ABC_transptr_permease_BtuC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30472">
        <property type="entry name" value="PTHR30472"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01032">
        <property type="entry name" value="FecCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81345">
        <property type="entry name" value="SSF81345"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="21"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="83"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="110"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="135"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="168"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="257"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="296"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="327"/>
            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PJN11349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="353" mass="35519" checksum="F6B99AFAA149BD42" modified="2018-04-25" version="1">MSVEAAPSPATGKRPHAVRGVFAWPAGLAVLIASVALAITIGPADIGMTDVWSAVVSHLGLGEPELTPIRDGIVWNLRLPRTLLAAVCGAGLAVCGAVMQSLLRNPLADPFVLGVSSGASTGAVLVVVLGVGGGALSVSGGAFLGAVVSFALVLALSQALGGSTDRVVLSGVAAMQLFSALTSVVVLTAADAETTRGVLFWLLGSLGGAGWTDVRMCLVLLVATLVICVGHARTLDAFAFGQDAAASLGVNVARTRLVLLCTTALLTAALVSSAGAIGFVGLVLPHAARALAGPGHARLLPVTALAGAVFLVWVDTLARTVLDPQEVPVGVVTSLIGVPAFVLVLYRTRSLRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JWY6</accession>
    <name>A0A2M9JWY6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Thioesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_10835</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN11406.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN11406">
        <property type="protein sequence ID" value="PJN11406"/>
        <property type="gene ID" value="CG723_10835"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025540">
        <property type="entry name" value="FlK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36934">
        <property type="entry name" value="PTHR36934"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF014972">
        <property type="entry name" value="FlK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="SSF54637"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" evidence="1">
        <location>
            <position position="24"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="32"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="58"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="51"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="104"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR014972-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR014972-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN11406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="132" mass="14121" checksum="AA711972B4B8AE07" modified="2018-04-25" version="1">MRHEVSDAHTARTVGSGDLPVLATPWLIAWMEAATVRAAAPFTAQGRTTVGTGVRIKHLRATRVGAWVDVLAEPPAEAEGRRLTFRVRALDSTGALVATGEIDRAIVDRRRFLSGVSDQDSGIDQGARGDHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JWZ0</accession>
    <name>A0A2M9JWZ0_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Sulfur carrier protein FdhD</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">fdhD</name>
        <name evidence="4" type="ORF">CG723_10875</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CB01635</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the FdhD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN11413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN11413">
        <property type="protein sequence ID" value="PJN11413"/>
        <property type="gene ID" value="CG723_10875"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097163">
        <property type="term" value="F:sulfur carrier activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016783">
        <property type="term" value="F:sulfurtransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006777">
        <property type="term" value="P:Mo-molybdopterin cofactor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00187">
        <property type="entry name" value="FdhD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016193">
        <property type="entry name" value="Cytidine_deaminase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003786">
        <property type="entry name" value="FdhD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30592">
        <property type="entry name" value="PTHR30592"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02634">
        <property type="entry name" value="FdhD-NarQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015626">
        <property type="entry name" value="FdhD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53927">
        <property type="entry name" value="SSF53927"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00129">
        <property type="entry name" value="fdhD_narQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 3" id="KW-0501">Molybdenum cofactor biosynthesis</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="active site" description="Cysteine persulfide intermediate" evidence="3">
        <location>
            <position position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PJN11413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="278" mass="29166" checksum="2BD9982478E7B8EA" modified="2018-04-25" version="1">MGRVTARRRVLRVRDGVSSYRPDTMAVEEPMEIRVGGRALTVTMRTPGDDFDLAAGFLVSEGVVHTGDDVTGIRYCAGATADGGNTYNVVDVALAPGVAAPDASLERNFYTTSSCGLCGKASLDAVRTTAAWTVSEDPLRVGPELVTALPDRLRAAQKVFDSTGGLHAAGLFNADGELLCLREDVGRHNAVDKVVGFALREGLLPLRETVLMVSGRASFELVQKALMAGVPMLAAVSAPSSLAVDLAAESGLTLIGFLRGTSMNVYTGAERLEQVPVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JX84</accession>
    <name>A0A2M9JX84_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">NUDIX hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_11395</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN11500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN11500">
        <property type="protein sequence ID" value="PJN11500"/>
        <property type="gene ID" value="CG723_11395"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020084">
        <property type="entry name" value="NUDIX_hydrolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="SSF55811"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00893">
        <property type="entry name" value="NUDIX_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="2">
        <location>
            <begin position="3"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN11500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="154" mass="16891" checksum="F9CF52366424BA0B" modified="2018-04-25" version="1">MAYKKQSAGLLLFRRTAAGTEVLLGHMGGPFWERRDAGAWTVPKGEYEDDEEPWAAARREFQEELGLAPPDGTPVPLGDTVQSGGKHVTVWAVEGDLDLDGFVPGTFTMEWPKGSGRMAEFPELDRAAWLGLDAARPLVVQAQTVFLDRLAEHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JX94</accession>
    <name>A0A2M9JX94_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">D-xylose ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CG723_10665</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN11377.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN11377">
        <property type="protein sequence ID" value="PJN11377"/>
        <property type="gene ID" value="CG723_10665"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="7"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="250"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="39"/>
            <end position="46"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PJN11377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="498" mass="52749" checksum="B3AA816905984816" modified="2018-04-25" version="1">MREPPVLAVEGLDKSFGAVRALHGVSLQLHAGEAHALAGENGAGKSTLIKTLAGVHRPDAGTVLIDGEPVTLHGPADARDAGIAVIYQEPTLFPDLSVAENIFMGRQPRRSLGRIDHKAVNAAAAALFARLGVDLDPEQPARGLSIADQQIVEIAKALSFDARVLIMDEPTAALTGSEVARLFAVVRTLREQGSAILFISHRLEEIFGLCQRVTTLRDGTLIASEPVEGLTEDDLVRRMVGRDLDELYPKQATDIGAVALSVRRLTREGVFTDVSFDVRRGEIVGLAGLVGAGRSEVARAVFGIDRRDAGTVEVDGRALVNGAPSTAMAAGLALVPEDRRAQGLVMGMSIERNIGLTGLRTTARAGLMDRGAERSRSLDWAMKLQVKYARIADAVGTLSGGNQQKVVLAKWLATGPRVLIVDEPTRGIDVGTKAEVHRLLSGLAADGVAVLMISSDLPEILGMADRVLVMHEGRLTAEIPRTEATEESVMAAATGRAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JXP5</accession>
    <name>A0A2M9JXP5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Enoyl-CoA hydratase</fullName>
            <ecNumber evidence="3">4.2.1.17</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_12295</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the enoyl-CoA hydratase/isomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.17" evidence="3"/>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN11653.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN11653">
        <property type="protein sequence ID" value="PJN11653"/>
        <property type="gene ID" value="CG723_12295"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004300">
        <property type="term" value="F:enoyl-CoA hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.12.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018376">
        <property type="entry name" value="Enoyl-CoA_hyd/isom_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014748">
        <property type="entry name" value="Enoyl-CoA_hydra_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00166">
        <property type="entry name" value="ENOYL_COA_HYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN11653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="254" mass="25954" checksum="BE414249B345EA18" modified="2018-04-25" version="1">MSDLVLTSFSDGVAVVTINRPEARNAVNRAVADAVAEAIDELDARDDLVVGVITGAGGTFCAGADLKALAAGERSGIPGRGFCGVTETPPAKPLIAAVEGYALGGGTELALACDMVVAARTAKFGLPETKRGLIAAGGGLVRLPRKIPYNIAMQYALTGAFLSAERAHGLGLVNELTEQGEALTGALALAQDIAANGPLAVRASKQIVVESADWTADETWEHNTAACAPVFASADAKEGARAFAEKRAPVWGSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JXQ7</accession>
    <name>A0A2M9JXQ7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Dihydrodipicolinate synthase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_12340</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DapA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN11660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN11660">
        <property type="protein sequence ID" value="PJN11660"/>
        <property type="gene ID" value="CG723_12340"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002220">
        <property type="entry name" value="DapA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12128">
        <property type="entry name" value="PTHR12128"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00701">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001365">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01130">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRNR" id="PIRNR001365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN11660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="325" mass="35035" checksum="E22D2A376AD29823" modified="2018-04-25" version="1">MSTEESEELTKDCKKSAKDVDSLVRGVSPVLEVPFRDDGALDPDGFATVVDRVLATGVGSVMFPGFASEFHKLDAGERDLLTGLLLERTRGRADAAAIVSVPDHATRHAVAQAVSAAERGADAVNVLPPHFLGPSRDAVLTHVRSVLAAVDPLPVVVQYAPAQTGTALDAPTLHTLAAEHPNLRWVKVESAPPGRLIAALAQGERPLPALVGYAGLQLPDALRRGAVGVQPGCSFTELYVELWRRWERGDETGAVALHTRMTPYLSYWMQGVELIVAAEKEISVRRGWFGSAHCRAPGHTLDSEEIAMIDRFCAEFAEMVPELLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JY22</accession>
    <name>A0A2M9JY22_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">TetR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_13020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN11769.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN11769">
        <property type="protein sequence ID" value="PJN11769"/>
        <property type="gene ID" value="CG723_13020"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="1">
        <location>
            <begin position="22"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00440"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN11769.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="209" mass="22565" checksum="F5E0638E41E3DEEA" modified="2018-04-25" version="1">MISSGTTAARLTTKGAATRLRIVEGAAAEIRERGAATTTLDDIRARTATSKSQIFHYFPGGKDELLLAVAALEAQRILEDQQPYLDDLGRLDTWQAWRDWRGAVVRRYERQGVNCPLGVLMTELGRRTPASQQLTGQLLAQWQSALRDGVRCMQGSGRMDPALDADRTAAALVAAVQGGVTVLMATGSIAHLEAALDTTLELLGRFSAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-06-02" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JY82</accession>
    <name>A0A2M9JY82_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_13420</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN11835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN11835">
        <property type="protein sequence ID" value="PJN11835"/>
        <property type="gene ID" value="CG723_13420"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="43"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN11835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="59" mass="6448" checksum="23262FBF05362D95" modified="2018-04-25" version="1">MSKNSPAKGHHGIGARGQGKLLYFHSQIPQAAVKQAKDQLPGKSQQPHDHRKANGRWAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JYB2</accession>
    <name>A0A2M9JYB2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">GntR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CG723_13505</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN11848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN11848">
        <property type="protein sequence ID" value="PJN11848"/>
        <property type="gene ID" value="CG723_13505"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07377">
        <property type="entry name" value="WHTH_GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.530">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011711">
        <property type="entry name" value="GntR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008920">
        <property type="entry name" value="TF_FadR/GntR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07729">
        <property type="entry name" value="FCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
        <property type="entry name" value="GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00035">
        <property type="entry name" value="HTHGNTR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00895">
        <property type="entry name" value="FCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00345">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48008">
        <property type="entry name" value="SSF48008"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50949">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH gntR-type" evidence="4">
        <location>
            <begin position="8"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PJN11848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="217" mass="24000" checksum="7C2B74853152D5D4" modified="2018-04-25" version="1">MAGDDTFEPESDRVTRTLRDQILDGVRAPGSKLVERELAAELGVSRLPVRDALKDLVNEGLVTPRPRSWAVVREFTASDVEDLDEVKAALEMLAFRLAAQRRTRAGLARLRADLDAELTAAAKGDAVPARRAAADFHETVTALADNELLNELGRTLSSRMRWLLGQHDDIAGVAKEHEELYEAIEARDVPRVEELALKHLATGRSEAAAHRRRTPEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JYE9</accession>
    <name>A0A2M9JYE9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MarR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_13765</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN11892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN11892">
        <property type="protein sequence ID" value="PJN11892"/>
        <property type="gene ID" value="CG723_13765"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000835">
        <property type="entry name" value="HTH_MarR-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01047">
        <property type="entry name" value="MarR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00598">
        <property type="entry name" value="HTHMARR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00347">
        <property type="entry name" value="HTH_MARR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50995">
        <property type="entry name" value="HTH_MARR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH marR-type" evidence="1">
        <location>
            <begin position="16"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN11892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="163" mass="17733" checksum="05C034BA560085D6" modified="2018-04-25" version="1">MTSPTSPTSPSDHEQSVEIAERLRAAIQQLLPELRAQGMQSQLTPSRLAALAALAAHGPLRISDLATRMGIALSTVSRMVDLLDGFGWIERDADPKDQRATLIALNDAGQALLHATRRQAATRLAERIDQLTPGQQRSLHDALPALDALTEQRPGEPPRISRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JYF9</accession>
    <name>A0A2M9JYF9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CG723_13850</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN11904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN11904">
        <property type="protein sequence ID" value="PJN11904"/>
        <property type="gene ID" value="CG723_13850"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010296">
        <property type="entry name" value="DUF899_thioredox"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05988">
        <property type="entry name" value="DUF899"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PJN11904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="230" mass="25787" checksum="467C97A1AA60ABA5" modified="2018-04-25" version="1">MATTENALPSVVDAATWQKELAALRVREKAATRELDAIAAQRRQLPMVEMPDYVLEGEDGPVRLAEIFGDHPQLIVYNHMWFEDAEWQCSGCTGFTTQFTRLMGLEKFDARFVIVTQGPIDEALAYKRKVGNEMTWYSTANSSFGGDVGAPPNAGFAVNVFLRDGDKVYRTWHTDGRGVEGLSYLFGLVDLLPYGRQEEWQDSPEGWPQQPTYSRWAESAEMAAAYGENS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JZ51</accession>
    <name>A0A2M9JZ51_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_14625</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN12037.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN12037">
        <property type="protein sequence ID" value="PJN12037"/>
        <property type="gene ID" value="CG723_14625"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN12037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="116" mass="12093" checksum="86AD0F8B9035CBC9" modified="2018-04-25" version="1">MAAKDDAPSRPFLIPKARLAIGSVTAALVVFAAGYGVGTATATSGHSKGTQRESRADVYRDGYLAGQKISGAGEEITADAARETCGELFYQAPYLDEWQSGCLAGAQHLAPYPPSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JZ88</accession>
    <name>A0A2M9JZ88_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DUF5133 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CG723_12385</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN12181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN12181">
        <property type="protein sequence ID" value="PJN12181"/>
        <property type="gene ID" value="CG723_12385"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033457">
        <property type="entry name" value="DUF5133"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17196">
        <property type="entry name" value="DUF5133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PJN12181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="90" mass="9730" checksum="D1850A027E19932B" modified="2018-04-25" version="1">MLLPTKTEVASHLAQYRAWERLRLAAPADRQVRAHFEDTAYTLCVLMGKRCGREAADAAEHYLRPSVEHPPMAAPPLAAPAVAVAALSGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JZE4</accession>
    <name>A0A2M9JZE4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">LysR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_14705</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LysR transcriptional regulatory family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN12236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN12236">
        <property type="protein sequence ID" value="PJN12236"/>
        <property type="gene ID" value="CG723_14705"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005119">
        <property type="entry name" value="LysR_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000847">
        <property type="entry name" value="Tscrpt_reg_HTH_LysR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00126">
        <property type="entry name" value="HTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03466">
        <property type="entry name" value="LysR_substrate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00039">
        <property type="entry name" value="HTHLYSR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50931">
        <property type="entry name" value="HTH_LYSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH lysR-type" evidence="2">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN12236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="302" mass="32212" checksum="57A25F87857894C0" modified="2018-04-25" version="1">MDLQQMRYVIAVAETRNFTRAAERCSVVQSSLSHRIAGLERELGIKLFARSSRRVELTSAGAAFVAGARECLAAADRAVADAAAATGVIRGRLAVGVIVTTAAVDVPDLLQRYRAQHPDVHVALRSGRSDELATAIRNGDLDIAFLGLPEGDRPSGVESVVLDHDEHVLAVPAGHRLAGVSHVTLREIADETFVDFVAGTPARAQSDQAFAAAGLVRDVAYESGVVELITRLIARGLGIALLPSAFIRPLVTDTPELALVPVVDGPHRIEYLAWSRFNPSPATRAMLKVLGVGRQALEQEVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K098</accession>
    <name>A0A2M9K098_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">rRNA methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CG723_05255</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000002">
        <property type="protein sequence ID" value="PJN12447.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN12447">
        <property type="protein sequence ID" value="PJN12447"/>
        <property type="gene ID" value="CG723_05255"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015324">
        <property type="entry name" value="Ribosomal_Rsm22-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09243">
        <property type="entry name" value="Rsm22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0808">Transferase</keyword>
    <keyword evidence="3" id="KW-0809">Transit peptide</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PJN12447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="338" mass="35868" checksum="212E4FCFFB2F7C59" modified="2018-04-25" version="1">MDAPLTPYSPASPADTLRAALAGLLDGLPPTQAARAVERLIASYRGSTPTDAPILRDRADVAAYAAYRMPATFEAVRSALGALADAAPEGWAPGSQVDVGGGTGAAVWAVADTWAGERPVTVLDWAEPALALGRELAGSCDRLTSARWQRSRIGAALTIESTDLVTVSYVLKELTEDDRRSVVDAAAAAASPDGAVVVVEPGTPDGYERIIEARRRLIDAGFHVAAPCPHSAACPIEPGTDWCHFSARVSRSSLHRQVKGGSLAYEDEKFSYVAATRFAPERPAARITRRPQIRKGQVLLDLCEAEGALGRETVTKRHGPLYRAARDADWGDAWPPAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K0X9</accession>
    <name>A0A2M9K0X9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Tellurium resistance protein terZ</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_07130</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000002">
        <property type="protein sequence ID" value="PJN12776.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN12776">
        <property type="protein sequence ID" value="PJN12776"/>
        <property type="gene ID" value="CG723_07130"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06974">
        <property type="entry name" value="TerD_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003325">
        <property type="entry name" value="TerD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02342">
        <property type="entry name" value="TerD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TerD" evidence="1">
        <location>
            <begin position="11"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN12776.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="200" mass="21370" checksum="01D0F87A4CBDF396" modified="2018-04-25" version="1">MTANFSKGPGVNLSKGQAISLQKQDGGNLTAVRMGLGWQAAPRRGLFGTRTREIDLDASAVLFADKQPVDVVFFRHLVSDDGSVRHTGDNLVGGAGQGGDDEAILVDLERVPVHIDQIVFTVNSFTGQTFQEVQNAFCRLVDETNGQELARYTLDGGGQYTAQIMAKVHRAGAGWQMTALGAPANGRTFQDLMPAILPGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K115</accession>
    <name>A0A2M9K115_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_07360</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000002">
        <property type="protein sequence ID" value="PJN12822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN12822">
        <property type="protein sequence ID" value="PJN12822"/>
        <property type="gene ID" value="CG723_07360"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014857729" evidence="1">
        <location>
            <begin position="34"/>
            <end position="464"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN12822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="464" mass="47601" checksum="C22E7DD92B14C25D" modified="2018-04-25" version="1">MQHFLPTSRRRAVAVTGGVLTLALAGLNSPAGAASYGTPTIALSASYVSGAVGATGDPVVTVTVGQSGADASALAVAASASSKSSVAGTGNVTVTGSGATRQVSVAAQGRGYTDLTLKVTGVDGKTATKTLHYAASAAVQQGPDTRYFTGSSDASAAVDAGGGYVLVADDESNVLRLYSGSVSGAPVKTWDFSSQLGVTKEVDIEGATRVGDTIYWTGSLGNNKDGEYKTPRNTVFTTTVSGSGAATQLSYGKAYKKLRDDLVAWDEANGDRYGFAAGTEDGQVPKQVDGFNVEGLEFAPGSTSTAYIGFRAPLVPPEDGGKALIVPVTNFDKVVASGTKPVFGTPVELDLGGLSVRDIRKNAANQYLIVAGSWAADDNSDPYALYQWDGVAGHAPVKRMDLPTSDPGGWEAVVSVPDLTQSGARAQLLTDNGSADLYGDGTEAKDLTHPEWKKSRAAWFGVTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K1D0</accession>
    <name>A0A2M9K1D0_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">3-oxoacyl-[acyl-carrier-protein] reductase</fullName>
            <ecNumber evidence="3">1.1.1.100</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">fabG</name>
        <name evidence="4" type="ORF">CG723_07955</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CB01635</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the NADPH-dependent reduction of beta-ketoacyl-ACP substrates to beta-hydroxyacyl-ACP products, the first reductive step in the elongation cycle of fatty acid biosynthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>a (3R)-hydroxyacyl-[ACP] + NADP(+) = a 3-oxoacyl-[ACP] + H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:17397"/>
            <dbReference type="Rhea" id="RHEA-COMP:9916"/>
            <dbReference type="Rhea" id="RHEA-COMP:9945"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:78776"/>
            <dbReference type="ChEBI" id="CHEBI:78827"/>
            <dbReference type="EC" id="1.1.1.100"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Lipid metabolism; fatty acid biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.100" evidence="3"/>
    <dbReference type="EMBL" id="NNBL01000002">
        <property type="protein sequence ID" value="PJN12929.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN12929">
        <property type="protein sequence ID" value="PJN12929"/>
        <property type="gene ID" value="CG723_07955"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00094"/>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004316">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011284">
        <property type="entry name" value="3oxo_ACP_reduc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01830">
        <property type="entry name" value="3oxo_ACP_reduc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="3" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="3" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="3" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="2 3" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Proton acceptor" evidence="1">
        <location>
            <position position="144"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="9"/>
            <end position="12"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="79"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="144"/>
            <end position="148"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR611284-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR611284-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU366074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PJN12929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="238" mass="25147" checksum="D5EB9E0BC29E5DB9" modified="2018-04-25" version="1">MSRSVLVTGGNRGIGLAIARAFADAGDKVAITYRSGDASELEKAGLLAVKCDITDSEQVEQAYKEIEEKHGPVEVLVANAGVTKDQLLMRMSEDDFTSVLDTNLTGTFRVVKRANRGMLRAKKGRVVLISSVVGLLGSAGQANYAASKAGLVGFARSLARELGSRNLTFNVVAPGFVDTDMTKALTDEQREGIVKQVPLGRYAQPEEIAATVRFLASDDASYITGAVIPVDGGLGMGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K1J8</accession>
    <name>A0A2M9K1J8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glyoxalase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_05470</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000002">
        <property type="protein sequence ID" value="PJN12989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN12989">
        <property type="protein sequence ID" value="PJN12989"/>
        <property type="gene ID" value="CG723_05470"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004360">
        <property type="entry name" value="Glyas_Fos-R_dOase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00903">
        <property type="entry name" value="Glyoxalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VOC" evidence="1">
        <location>
            <begin position="4"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN12989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="143" mass="15564" checksum="4C06723EE0958793" modified="2018-04-25" version="1">MDWTLEVIVVPVTDVDRAKDFYAKQLGFKVDVDQVVTEGIRIVQLTPPGSRCSITLTQGLPGPPGQRPMAPGSLTGLQMCVTDIVAARAELVERGVDVSRVQHADVTGWEDGPGELWNSFMFFTDPDGNGWIVQEAPAPLSER</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K242</accession>
    <name>A0A2M9K242_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 6">Ornithine carbamoyltransferase</fullName>
            <shortName evidence="6">OTCase</shortName>
            <ecNumber evidence="3 6">2.1.3.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">argF</name>
        <name evidence="10" type="ORF">CG723_00970</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CB01635</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>carbamoyl phosphate + L-ornithine = H(+) + L-citrulline + phosphate</text>
            <dbReference type="Rhea" id="RHEA:19513"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:46911"/>
            <dbReference type="ChEBI" id="CHEBI:57743"/>
            <dbReference type="ChEBI" id="CHEBI:58228"/>
            <dbReference type="EC" id="2.1.3.3"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the aspartate/ornithine carbamoyltransferase superfamily. OTCase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.3.3" evidence="3 6"/>
    <dbReference type="EMBL" id="NNBL01000001">
        <property type="protein sequence ID" value="PJN13196.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN13196">
        <property type="protein sequence ID" value="PJN13196"/>
        <property type="gene ID" value="CG723_00970"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016597">
        <property type="term" value="F:amino acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004585">
        <property type="term" value="F:ornithine carbamoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1370">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01109">
        <property type="entry name" value="OTCase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006132">
        <property type="entry name" value="Asp/Orn_carbamoyltranf_P-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006130">
        <property type="entry name" value="Asp/Orn_carbamoylTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036901">
        <property type="entry name" value="Asp/Orn_carbamoylTrfase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006131">
        <property type="entry name" value="Asp_carbamoyltransf_Asp/Orn-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002292">
        <property type="entry name" value="Orn/put_carbamltrans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024904">
        <property type="entry name" value="OTCase_ArgI"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00185">
        <property type="entry name" value="OTCace"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02729">
        <property type="entry name" value="OTCace_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00100">
        <property type="entry name" value="AOTCASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00102">
        <property type="entry name" value="OTCASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53671">
        <property type="entry name" value="SSF53671"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00658">
        <property type="entry name" value="orni_carb_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00097">
        <property type="entry name" value="CARBAMOYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="OTCace_N" evidence="9">
        <location>
            <begin position="11"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="domain" description="OTCace" evidence="8">
        <location>
            <begin position="160"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="region of interest" description="Carbamoyl phosphate binding" evidence="6">
        <location>
            <begin position="60"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Carbamoyl phosphate binding" evidence="6">
        <location>
            <begin position="138"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Ornithine binding" evidence="6">
        <location>
            <begin position="239"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Carbamoyl phosphate binding" evidence="6">
        <location>
            <begin position="277"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="87"/>
        </location>
        <ligand>
            <name>carbamoyl phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58228"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="111"/>
        </location>
        <ligand>
            <name>carbamoyl phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58228"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="171"/>
        </location>
        <ligand>
            <name>L-ornithine</name>
            <dbReference type="ChEBI" id="CHEBI:46911"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="235"/>
        </location>
        <ligand>
            <name>L-ornithine</name>
            <dbReference type="ChEBI" id="CHEBI:46911"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="322"/>
        </location>
        <ligand>
            <name>carbamoyl phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58228"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00016634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PJN13196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="335" mass="36689" checksum="EF933966FB2ED059" modified="2018-04-25" version="1">MATVRPDLTGRHFLKEVDFTAEEFRGLIDLAAELKAAKKAGTETRHLAGRNIALIFEKTSTRTRCAFEVAAADQGAFTTYLDPSGSQIGHKESVRDTARVLGRMFDAIEYRGDSQSGVEELAAYAGVPVYNGLTDDWHPTQMLADVLTMVEHCSKPLDRIAFAYLGDARFNMGNSYLVTGALLGMDVRIVAPREYWPAEEIVAEARKLAEASGSRVTLTEDVAEGVAGADFVATDVWVSMGEPKEVWAERITALKPYAVTMDVLRATGNADVKFLHCLPAFHDLGTKVGREIHETYGLDSLEVTDEVFESAHSVVFDEAENRLHTIKAIMVATLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K250</accession>
    <name>A0A2M9K250_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Dihydrofolate reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_01025</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000001">
        <property type="protein sequence ID" value="PJN13204.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN13204">
        <property type="protein sequence ID" value="PJN13204"/>
        <property type="gene ID" value="CG723_01025"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006140">
        <property type="entry name" value="D-isomer_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02826">
        <property type="entry name" value="2-Hacid_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="2-Hacid_dh_C" evidence="1">
        <location>
            <begin position="107"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN13204.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="310" mass="33590" checksum="DB1A5A102783E5D2" modified="2018-04-25" version="1">MTETDVLVPWPQLDQRHGPWPDGVRVHVWDGVTPASELPQDALDAVEFWVMPYAVPDADRLLPRLPRLRAVQSLSAGVEKLQPLLPEGVTLHNGRGLHDASTAEHALGLILAAQRELPRWAADQVAGRWDPHFTRSLADSRVAIVGYGSIGSALEARLLACEADVVRVARRARPDERVHAIADLPELLPGLDIVVLVLPENPATVGLFGPKEMAALPDGALVVNVGRGRTLDTEALLAETATGRLRAALDVTDPEPLPADHALRHAPGVLITPHVAGGSAAFRPRAERLIAEQIRRWAAEEELLNLFPRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-06-02" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K287</accession>
    <name>A0A2M9K287_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_00605</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000001">
        <property type="protein sequence ID" value="PJN13137.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN13137">
        <property type="protein sequence ID" value="PJN13137"/>
        <property type="gene ID" value="CG723_00605"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="294"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN13137.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="321" mass="33956" checksum="A0BD8805FB3F3D40" modified="2018-04-25" version="1">MTGSTPPWKRRSRKDREADGGPSDDGVRDDERGSSPTGAASLEDADDREVTGDLAAAGFSDLPAVPTAGDQAPIGGRAQVARRRVAAVRDGVRKSGTAAKAGLGYLADRIIENAPRVPVRDLATLRRQFPGLSAEQLADKLVAGAANATSTVGAGIGAAAMMPVPPAMPAELAAEITGVAAIEMKLVAELHEVYGVRPPGALKDRSAAYLASWTEERGIEVTKPATINAALGGQMKRELRQQIMKRMVRNLPNLMPFMVGAAVGAVMNRRDTKKLAGRIRKDLRKIQVPWDALPELPPLERPSDPHPLIPGDASEPKELGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K2B7</accession>
    <name>A0A2M9K2B7_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 11">UDP-N-acetylmuramate--L-alanine ligase</fullName>
            <ecNumber evidence="4 11">6.3.2.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">UDP-N-acetylmuramoyl-L-alanine synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">murC</name>
        <name evidence="15" type="ORF">CG723_01405</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">CB01635</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Cell wall formation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>ATP + L-alanine + UDP-N-acetyl-alpha-D-muramate = ADP + H(+) + phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanine</text>
            <dbReference type="Rhea" id="RHEA:23372"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57972"/>
            <dbReference type="ChEBI" id="CHEBI:70757"/>
            <dbReference type="ChEBI" id="CHEBI:83898"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.2.8"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 11">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 11">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the MurCDEF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.8" evidence="4 11"/>
    <dbReference type="EMBL" id="NNBL01000001">
        <property type="protein sequence ID" value="PJN13272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN13272">
        <property type="protein sequence ID" value="PJN13272"/>
        <property type="gene ID" value="CG723_01405"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008763">
        <property type="term" value="F:UDP-N-acetylmuramate-L-alanine ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007049">
        <property type="term" value="P:cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00046">
        <property type="entry name" value="MurC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036565">
        <property type="entry name" value="Mur-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004101">
        <property type="entry name" value="Mur_ligase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036615">
        <property type="entry name" value="Mur_ligase_C_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013221">
        <property type="entry name" value="Mur_ligase_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000713">
        <property type="entry name" value="Mur_ligase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005758">
        <property type="entry name" value="UDP-N-AcMur_Ala_ligase_MurC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01225">
        <property type="entry name" value="Mur_ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02875">
        <property type="entry name" value="Mur_ligase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08245">
        <property type="entry name" value="Mur_ligase_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53244">
        <property type="entry name" value="SSF53244"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53623">
        <property type="entry name" value="SSF53623"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01082">
        <property type="entry name" value="murC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9 11" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="6 11" id="KW-0132">Cell division</keyword>
    <keyword evidence="7 11" id="KW-0133">Cell shape</keyword>
    <keyword evidence="10 11" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="5 11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11 15" id="KW-0436">Ligase</keyword>
    <keyword evidence="11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8 11" id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mur_ligase" evidence="12">
        <location>
            <begin position="13"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="domain" description="Mur_ligase_M" evidence="14">
        <location>
            <begin position="115"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="domain" description="Mur_ligase_C" evidence="13">
        <location>
            <begin position="317"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="117"/>
            <end position="123"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF02875"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF08245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="PJN13272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="464" mass="48183" checksum="09192B9DCD544DAD" modified="2018-04-25" version="1">MAPGLPTAMDRPHFIGIGGAGMSGIAKILTQRGAQVAGSDSRESATAEALRSLGATVHIGHDAAHLAPDATCVVVSSAIRADNPELARAAELGIPVVHRSDALASLMDGLRPIAVAGTHGKTTTTSMLAVSLSSLGLDPSYAIGGDLDAPGSNALHGEGEIFVAEADESDRSFHKYAPEVAIVLNVELDHHANYASMDEIYESFETFASKIVPGGTLVIAADQSGAVELTRRLRDTTSLKVVTYGESEAADVRIHKVTPRGLTSEVTVLLDGKLLTFTVSVPGRHYAHNAVAALAAGVALGIPSRNLAAALKSYTGVKRRLQLKGEENGVQVIDSYAHHPTEMSADLEAMRSAAGDSRILVVFQPHLFSRTQELGKEMGDALALADASVVLDIYPAREDPIPGITSGLIIDAARAAGADVDAVQDKATVPDVIAGMAKPGDLVLTMGAGDVTELGPQILDRLAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-06-02" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K2K6</accession>
    <name>A0A2M9K2K6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">GntR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CG723_01925</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000001">
        <property type="protein sequence ID" value="PJN13361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN13361">
        <property type="protein sequence ID" value="PJN13361"/>
        <property type="gene ID" value="CG723_01925"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.530">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011711">
        <property type="entry name" value="GntR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008920">
        <property type="entry name" value="TF_FadR/GntR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07729">
        <property type="entry name" value="FCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
        <property type="entry name" value="GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00895">
        <property type="entry name" value="FCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00345">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48008">
        <property type="entry name" value="SSF48008"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50949">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH gntR-type" evidence="5">
        <location>
            <begin position="54"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="34"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PJN13361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="257" mass="27531" checksum="29F4FDF245131A57" modified="2018-04-25" version="1">MEQARTRADSAPSGLPAGVPEQRGTAGWHQVPEQTRGEHTHSETPLPRPRVERTSVRGQVLDALRTALVDGELVPGEVYSAPVLGDGLGVSATPVREAMQQLAREGAVEVVPNRGFRVTERSARELAELAEVRALIEVPVVLRLARTVPVARWAELRPLADATAVAAAGGDRAHYAETDRAFHRAMLALGGNEQLVRVADDLHRRSQWPLPGGGPLSRRADLVADAAEHMALLAALEAQDLTVVQALVREHFAGAAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K2T5</accession>
    <name>A0A2M9K2T5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CG723_02420</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000001">
        <property type="protein sequence ID" value="PJN13445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN13445">
        <property type="protein sequence ID" value="PJN13445"/>
        <property type="gene ID" value="CG723_02420"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PJN13445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="116" mass="12271" checksum="73C5481068CB3EEE" modified="2018-04-25" version="1">MHAPRSDSETGTVGFARWVPVTGADDDYAGEMVLVGGPDAGRVGRWSSSDSSCLHHEYASFSTYLDAVADALESGTGPLACRNRVVPGVALGSLVWQDPQAVSAVEAEWVPVHRSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K2U8</accession>
    <name>A0A2M9K2U8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MBL fold metallo-hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_02440</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000001">
        <property type="protein sequence ID" value="PJN13448.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN13448">
        <property type="protein sequence ID" value="PJN13448"/>
        <property type="gene ID" value="CG723_02440"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lactamase_B" evidence="1">
        <location>
            <begin position="7"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN13448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="211" mass="23174" checksum="9949DE50A68EEEFD" modified="2018-04-25" version="1">MKLTKKIHACVRLEKDGRTLVIDPGGFCEEDAAVGAEAILVTHEHPDHFDETRLRVALEADPATEIWTLKSVADKISTAFPGRVHTVGHGDTFEAAGFDIQVHGELHAVIHPDIPRITNVGYLIDHGRVFHPGDAFTVPDQPVETLLVPVMAPWNKIAEVIDYLREVGPQRAYDIHDALLTDLAWPIYDGQIAALGGTDNLRLTPEECATL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K3A2</accession>
    <name>A0A2M9K3A2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Type A2 lantipeptide</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CG723_03355</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000001">
        <property type="protein sequence ID" value="PJN13605.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN13605">
        <property type="protein sequence ID" value="PJN13605"/>
        <property type="gene ID" value="CG723_03355"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PJN13605.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="75" mass="7011" checksum="7C789161842CFAC2" modified="2018-04-25" version="1">MNSTPQVQTLEISDADLDNVSGGLVGGLAANLTGTADSIAPVSGVVGGLTGTVEGLTGVNTAAVTGLATGLTAGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K3G2</accession>
    <name>A0A2M9K3G2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Nucleotide sugar-1-phosphate transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_03720</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000001">
        <property type="protein sequence ID" value="PJN13665.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN13665">
        <property type="protein sequence ID" value="PJN13665"/>
        <property type="gene ID" value="CG723_03720"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005835">
        <property type="entry name" value="NTP_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00483">
        <property type="entry name" value="NTP_transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="NTP_transferase" evidence="1">
        <location>
            <begin position="3"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN13665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="250" mass="27399" checksum="E72A3B70A04BB463" modified="2018-04-25" version="1">MIGLVLAAGAGRRLRPYTDTLPKALVPVGPEGDEESLTVLDLTLGNFAEIGLTEVAIIVGYRKEAVYERREALEQKYGVKITLIDNDKAEEWNNAYSLWCGRDAIKHSVILANGDTVHPVSVEKTLLAARGDGKKIILALDTVKSLADEEMKVVVGPEGGMTKITKLMDPAEATGEYIGVTLIEGEAADELADALKTVFETDPQQFYEHGYQELVNRGFRIDVAPIGEVKWVEIDNHDDLAKGREIACQY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-05-25" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K3J4</accession>
    <name>A0A2M9K3J4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">LacI family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CG723_03955</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000001">
        <property type="protein sequence ID" value="PJN13701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN13701">
        <property type="protein sequence ID" value="PJN13701"/>
        <property type="gene ID" value="CG723_03955"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01392">
        <property type="entry name" value="HTH_LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000843">
        <property type="entry name" value="HTH_LacI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046335">
        <property type="entry name" value="LacI/GalR-like_sensor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00356">
        <property type="entry name" value="LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13377">
        <property type="entry name" value="Peripla_BP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00354">
        <property type="entry name" value="HTH_LACI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50932">
        <property type="entry name" value="HTH_LACI_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH lacI-type" evidence="4">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PJN13701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="337" mass="35767" checksum="74090FDFD17CEEE4" modified="2018-04-25" version="1">MTLDAVARTAGVSPATASRALNGTTRVRDDLLRRVRAAADELGYIPNAHAQALASASNNTVGVICHDVGDPYFAAIASGIMARAAERGLLVMLSSTFRAPEREIAYISMLRAQRTRAILLIGSGFQDPAWERSLESEIAPYLRGGGRVAVVSRHRSLRVDTVLPENRAGAAALARALLGLGHREFGVLAGPARLTTVADRLTGFRQGLAEAGVELADEKVVEGAFTRDGGYAAASELLRRAPRPTCVFAVTDVMAVGALAAFRDHGLRVPQDISLAGFDDIPLVRELTPPLTTVALPLTGMGRAALDLALREPRGPRSRVERIVGEVRIRASTATPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K3X6</accession>
    <name>A0A2M9K3X6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CG723_01015</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000001">
        <property type="protein sequence ID" value="PJN13737.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN13737">
        <property type="protein sequence ID" value="PJN13737"/>
        <property type="gene ID" value="CG723_01015"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014757">
        <property type="entry name" value="Tscrpt_reg_IclR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005471">
        <property type="entry name" value="Tscrpt_reg_IclR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09339">
        <property type="entry name" value="HTH_IclR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01614">
        <property type="entry name" value="IclR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00346">
        <property type="entry name" value="HTH_ICLR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51077">
        <property type="entry name" value="HTH_ICLR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51078">
        <property type="entry name" value="ICLR_ED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH iclR-type" evidence="3">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="domain" description="IclR-ED" evidence="4">
        <location>
            <begin position="62"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PJN13737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="245" mass="25898" checksum="9F143D0793146288" modified="2018-04-25" version="1">MLGRGLRLLTVLADHPAGLGVSAAARAAALPVSSAHRLLGRLAAERFVAYDEDTRRYALGARVLELSRGFQRSPAGYSAAAAPMRRLADRTGLPAIAGILYDTDVLLVLTAQGTQHLQLRSAEGTRNAWHATSLGKVLVAGLPERERDELLAAELAAVTDRTVTDPAAVRRELDAVRERGWAEVDEENEVGVRSIAVAVPSPHGEAPRLAVSLGAAVALTGADELRAHVPALRACAEDIAAHMDH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JEL2</accession>
    <name>A0A2M9JEL2_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">UPF0060 membrane protein CG723_45380</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CG723_45380</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CB01635</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the UPF0060 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000053">
        <property type="protein sequence ID" value="PJN05335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN05335">
        <property type="protein sequence ID" value="PJN05335"/>
        <property type="gene ID" value="CG723_45380"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00010">
        <property type="entry name" value="UPF0060"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003844">
        <property type="entry name" value="UPF0060"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36116">
        <property type="entry name" value="PTHR36116"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02694">
        <property type="entry name" value="UPF0060"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="33"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="62"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="91"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PJN05335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="112" mass="11886" checksum="CEE2AB9CEF9F790F" modified="2018-04-25" version="1">MLVARSALLFVVAALFEIGGAWLVWQGVREHRGWAWIGAGVIALGIYGFVATLQPDGEFGRILAAYGGVFVAGSIAWGMVADGYRPDRWDVTGALVCLAGMAVIMYAPRGGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JEL8</accession>
    <name>A0A2M9JEL8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_45405</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000053">
        <property type="protein sequence ID" value="PJN05340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN05340">
        <property type="protein sequence ID" value="PJN05340"/>
        <property type="gene ID" value="CG723_45405"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021235">
        <property type="entry name" value="DUF2637"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10935">
        <property type="entry name" value="DUF2637"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="48"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN05340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="83" mass="8829" checksum="C2A0A64E3BBF2637" modified="2018-04-25" version="1" fragment="single">MAAPQLTRTHRILIGVVVAGAVVIAGIGFAGSYAAVRSLAFQKGFGNFSYVFPIGIDAGICVLLALDLLLTWIRIPFPLLRQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JET6</accession>
    <name>A0A2M9JET6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glyoxalase/bleomycin resistance/dioxygenase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_45440</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000054">
        <property type="protein sequence ID" value="PJN05323.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN05323">
        <property type="protein sequence ID" value="PJN05323"/>
        <property type="gene ID" value="CG723_45440"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041581">
        <property type="entry name" value="Glyoxalase_6"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18029">
        <property type="entry name" value="Glyoxalase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glyoxalase_6" evidence="2">
        <location>
            <begin position="8"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="85"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF18029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN05323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="122" mass="12909" checksum="AFF0F30D43AC26CD" modified="2018-04-25" version="1">MPITLTSVIIDAADIDTESSFWHRLLGGSLTPTPTHHFIQAPGLPAIVVQSAPGHTAPNWPDGTSQQMHLDFGVDDLATADRTATEAGATRLRPTAEATPETHTGSRVYASPAGHPFCLRST</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JFC6</accession>
    <name>A0A2M9JFC6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_44745</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000048">
        <property type="protein sequence ID" value="PJN05457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN05457">
        <property type="protein sequence ID" value="PJN05457"/>
        <property type="gene ID" value="CG723_44745"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028961">
        <property type="entry name" value="Imm21"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15589">
        <property type="entry name" value="Imm21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="183"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="183"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN05457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="212" mass="22057" checksum="E6D9AECEACB1B859" modified="2018-04-25" version="1">MKTSSSMASSAEPSLTWVESMGGPLIAVPVSVVDGWRGCTESGIVIGDGDVSDDYDRACEVDGLAGVIAIGDEGARGLVLADEPATTCYLPEHQAFVRWLGADSEADLIAAAKAVLTNPTTQWEKCGAWETDGPAVLMDSVTDGAELDVEYPIGGGLPEQAPVPIPPGRWTVRAVHASPNDSTSVGLVQLLPSDGDPFSSGQEIRTRPHQDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JFD8</accession>
    <name>A0A2M9JFD8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">RimJ/RimL family protein N-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_43715</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000044">
        <property type="protein sequence ID" value="PJN05611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN05611">
        <property type="protein sequence ID" value="PJN05611"/>
        <property type="gene ID" value="CG723_43715"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13302">
        <property type="entry name" value="Acetyltransf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="12"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN05611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="192" mass="21348" checksum="CAB691CC97C0FD9E" modified="2018-04-25" version="1">MPTSFLSHGPRVAIRRVCDQDYEETTALARASTKLHHPWVPSRGSTRQEFASYMARFDQPTHDGFVVCLRQTGEIVGGVNINHIVKGPLQSGALGYVAYASTTGRGYMTEGLDLVVRFAFSELGLHRLEANIQPANTASLKLVERLGFRREGYSPGFQLIDGVWQDHERWAIAGDMMPLAPHPRYEDASDGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JFX6</accession>
    <name>A0A2M9JFX6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Dipeptide/oligopeptide/nickel ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CG723_43225</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000042">
        <property type="protein sequence ID" value="PJN05742.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN05742">
        <property type="protein sequence ID" value="PJN05742"/>
        <property type="gene ID" value="CG723_43225"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015833">
        <property type="term" value="P:peptide transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013563">
        <property type="entry name" value="Oligopep_ABC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08352">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01727">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="6"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="42"/>
            <end position="49"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PJN05742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="323" mass="35099" checksum="A9E3718E8444A939" modified="2018-04-25" version="1">MPEPLLSVTDLTVVYDTARGPVTAVDHVELIVEKGQFTAVVGESGCGKSTLMFAVARLLNPPARIAGGAVRFRGENLVTLGERELNALRWRDYSVVLQSAMNALNPVATLAAQYKDAMAAHGTYTNEEIRARSTEVLDLVGIDPVHLHSYPHQLSGGMRQRAMIAMALLLTPDLVIMDEPTSALDVVAQRSLMVQIKELQQLLGFAVVFVTHDMSLVSHFSDQLLVMYAGQVVEQGPTRTVFDHPSHPYSRGLLEAFPSIRGPRVPLKGIPGSPPDLAAPPAGCRFTPRCPLVHEQCHDTEPALYEVGTARSRCLLHLTEAVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JG60</accession>
    <name>A0A2M9JG60_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CG723_43190</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000042">
        <property type="protein sequence ID" value="PJN05737.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067429589.1">
        <property type="nucleotide sequence ID" value="NZ_NNBL01000042.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN05737">
        <property type="protein sequence ID" value="PJN05737"/>
        <property type="gene ID" value="CG723_43190"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043758">
        <property type="entry name" value="DUF5703"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18963">
        <property type="entry name" value="DUF5703"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PJN05737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="62" mass="7582" checksum="767F358BF5919FBE" modified="2018-04-25" version="1">MPEYEFVDVYVPRGVSRKDATRLLTDHAEYGHWELDRLSLLRDGSRRVRLRRRIIRQLRATW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JGA5</accession>
    <name>A0A2M9JGA5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">TetR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_42080</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000038">
        <property type="protein sequence ID" value="PJN05921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN05921">
        <property type="protein sequence ID" value="PJN05921"/>
        <property type="gene ID" value="CG723_42080"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023772">
        <property type="entry name" value="DNA-bd_HTH_TetR-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01081">
        <property type="entry name" value="HTH_TETR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="8"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="31"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN05921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="223" mass="24249" checksum="CCD6BAFF5C502E12" modified="2018-04-25" version="1">MAQQDRAIRTRQTLLSAAAKVFEERGYQSATISEILTTAGVTKGALYFHFPSKEHLAEGVLQEQGQQLPIPDRASKIQQLVDTVMVYAYRLQTDPMVQAGVRLTLDQQAHGLDRTAPFTQWGEIIQTLLDKAQSQGELLPHVVSAETAEVLVGSFAGVQAMSQAMRDHQDLLFRASALLRHVLPSVVLSSVLTSVDLSESRGAKVFAELQALEAEQAPPTSAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JH11</accession>
    <name>A0A2M9JH11_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PucR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_40545</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000034">
        <property type="protein sequence ID" value="PJN06168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN06168">
        <property type="protein sequence ID" value="PJN06168"/>
        <property type="gene ID" value="CG723_40545"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2840">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025736">
        <property type="entry name" value="PucR_C-HTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042070">
        <property type="entry name" value="PucR_C-HTH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13556">
        <property type="entry name" value="HTH_30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH_30" evidence="1">
        <location>
            <begin position="486"/>
            <end position="544"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN06168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="551" mass="57994" checksum="9A58AB2D9F236926" modified="2018-04-25" version="1">MLTPTSGKPHTSLARVLDDLGDVLLESIAGGGSTRRELSGVVIHDPLDEAQFPAQAVVLGVGVHEPDDVVRLLRDLGRNGAAVLVVRSPFTATGEVRRAADESGVALLGLAPGASWAQVAAMLRTLLVEGDIGDVSPQTLGGMPSGDLFALANAVAALLDAPVTIEDRSSRVLAFSGRQDEADQSRVETILGRQVPERFTLGLARNGVFDRLHRGHAPVYVDPLHDESMTVPRVALAVRAGDEILGSIWAAVPGPLSKERTQALIDAGKLVALHMLRLRAGADVERRLRADLVSTALEGGKGAPEAIARLGLVGQPAIVLALGLFGGSDADPSTEDGLRRVADRQRVADALAMHLSAVQARSAVALVGDVAYGIVPMPGSHADCQERSVRVASTFLERTGQRVDAAIGIGPPALDGSVLSRSRDGADRALRVLLAHGGARRVATAEEVHVDALMLDLADLAAARGDVATGPVARLLDYDARHQSQLVRTLSCWLDAFGDVAAASAAAYVHPNTFRYRLRRVAEVGEINLDDPGERFAAMLQLRLHPAHHCA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JH66</accession>
    <name>A0A2M9JH66_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Hyaluronate lyase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CG723_40095</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000033">
        <property type="protein sequence ID" value="PJN06224.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN06224">
        <property type="protein sequence ID" value="PJN06224"/>
        <property type="gene ID" value="CG723_40095"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016628">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008152">
        <property type="term" value="P:metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003953">
        <property type="entry name" value="FAD-binding_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011777">
        <property type="entry name" value="Geranylgeranyl_Rdtase_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00890">
        <property type="entry name" value="FAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02032">
        <property type="entry name" value="GG-red-SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD_binding_2" evidence="4">
        <location>
            <begin position="27"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="domain" description="FAD_binding_3" evidence="5">
        <location>
            <begin position="111"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="414"/>
            <end position="438"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PJN06224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="438" mass="46239" checksum="4B3FAA635AABDA41" modified="2018-04-25" version="1">MSSENSADGNGTGEHAADAGDGGQVWDVVVVGAGPAGASAAYAAAVAGRSVLLLEKAELPRYKTCGGGIIGPSRDALPPGFELPFRDRIDAVTFSLDGKFTRTRRSRHMLFGLVNRADFDHQLVEHAEKAGAELRTGTTVSRVEQHGAAVPDRRTVAVILQDGETILARAVVGADGSASRIGAHVGVKLDQVDLGLEAEIPVPETVAEDWKGRVLIDWGPMPGSYGWVFPKGDTLTVGVISARGEGAATKRYLEDFIARLGLAGFEPSVSSGHLTRCRADDSPLSRGRVLVCGDAAGLLEPWTREGISFALRSGRLAGEWAVRVSEAHDAVDARRQALNYAFAVKAGLGVEMSVGRRMLTVFERRPGVLHAAITGFRPAWKAFARITRGSTTLGEIVRTYPMAGRVLSRLDRPASAAASSADPSAVPTVDDPEATSRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JH94</accession>
    <name>A0A2M9JH94_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Peptide ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CG723_40240</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000033">
        <property type="protein sequence ID" value="PJN06250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN06250">
        <property type="protein sequence ID" value="PJN06250"/>
        <property type="gene ID" value="CG723_40240"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03255">
        <property type="entry name" value="ABC_MJ0796_LolCDE_FtsE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017911">
        <property type="entry name" value="MacB_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="11"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="47"/>
            <end position="54"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PJN06250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="262" mass="27839" checksum="8EF2A77B52F3DA56" modified="2018-04-25" version="1">MTTATRTRTAARVVDAVKVYGSGDTAVRALDGVSVGFEAGRFTAIMGPSGSGKSTLMHCAAGLDTLSAGSAFIGDTDLSDLDDRRLTLLRRDRIGFVFQAFNLVPTLTVAENITLPMDLAGAKDDAASREWIDALVDVVGLRDRLHHRPSELSGGQQQRVAVARAFAGRPDVVFADEPTGNLDSRSGEEVLGLLGRAVRQMDRTVVMVTHDPVAAAHADEVVFLADGRLVDRMQDPTPDKVLDRMKAFDAAGGARHAGETPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JHC1</accession>
    <name>A0A2M9JHC1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Class F sortase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_40360</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000033">
        <property type="protein sequence ID" value="PJN06271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN06271">
        <property type="protein sequence ID" value="PJN06271"/>
        <property type="gene ID" value="CG723_40360"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05829">
        <property type="entry name" value="Sortase_F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005754">
        <property type="entry name" value="Sortase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023365">
        <property type="entry name" value="Sortase_dom-sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042001">
        <property type="entry name" value="Sortase_F"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04203">
        <property type="entry name" value="Sortase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63817">
        <property type="entry name" value="SSF63817"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="45"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="67"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN06271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="251" mass="26204" checksum="AF5A8DD395E0BAED" modified="2018-04-25" version="1">MAARLPSPDQTESAPPERRSRRGPWIVWSVGIVVLLVSLFGGQEETSDITDSSGASRPAVELAPSSEPALPDPPTLPALPVPPTEPAAPAEPAAPAPVGKHLPRANPTRLLIPKIGVDAPFTRLAIGPTGQLQPPPAANTNLVGWQADGVSPGETGTAIIAGHVDTKTSAAVFAGLRALKTGDTFTVKRDDSSTASFVVDSVETFAKNAFPNERVYGDTPQAQVRLITCAGAYDHGKKDYTDNLVVFAHLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JHF7</accession>
    <name>A0A2M9JHF7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ketoacyl reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_39880</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000032">
        <property type="protein sequence ID" value="PJN06305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN06305">
        <property type="protein sequence ID" value="PJN06305"/>
        <property type="gene ID" value="CG723_39880"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN06305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="273" mass="28339" checksum="CC13F61FCA75333A" modified="2018-04-25" version="1">MTRTTTQESPPSPPSPAKPVALVTGATSGIGLAVARELGRRGHRVFICARTAQQVKQTVEDLREEGLEVDGTAADVRSAESMAALVRSAVDAFGPITVLVNNAGRSGGGPTAGITDDLWYDVIDTNLNGVFLLTREVLNNGGLADAQGGRIINIASTAGKQGVPLGAPYSASKHGVVGFTKALGKELAPRGVTVNAVCPGYVETPMAERVRQGYADAWGTTEDHVQEQFEAKIPLGRYSTPQEVAGLVGYLTTEHAASITAQALNVCGGLGNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JHM9</accession>
    <name>A0A2M9JHM9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_39705</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000031">
        <property type="protein sequence ID" value="PJN06385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN06385">
        <property type="protein sequence ID" value="PJN06385"/>
        <property type="gene ID" value="CG723_39705"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045652">
        <property type="entry name" value="DUF6397"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19934">
        <property type="entry name" value="DUF6397"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="265"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN06385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="313" mass="34223" checksum="C1DF90B05E70021F" modified="2018-04-25" version="1">MGGNTITTPATRVPAASLAQSRAARELGLKRGEFELAVRLGRVRTVPADAGGRRRVAREEIERVRDTAGFPDSLREQVRAVGTTEGAGLMDITTARFTRLARAGILTPVRFYLNRYRAVVWLYLAEELREFAAAEVNAPLMTGRAPDRIRARLDAGIDLRPRNWRSRHAGHLLGQSDDAWERASAVASLLDPVTVLELVKCPYERGYLSKLRPESTGHGAPDSPSARIAERIMTADDPHEISWLRASLLLSLAEARGLRPAPRPRAGFPAVAPPAPDVVLAEPSRATGEQSPPDTEPLHPSRGLLGWLRRRGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JHQ0</accession>
    <name>A0A2M9JHQ0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CG723_39025</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000030">
        <property type="protein sequence ID" value="PJN06411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN06411">
        <property type="protein sequence ID" value="PJN06411"/>
        <property type="gene ID" value="CG723_39025"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046248">
        <property type="entry name" value="DUF6281"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19797">
        <property type="entry name" value="DUF6281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PJN06411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="143" mass="14953" checksum="9A5442F63CEE8A80" modified="2018-04-25" version="1">MRIRIPRRRDADMSTRSRRLPLYSGMIMVVAALTTACSAQGGGGEAEGACAIAATYGGRTYTQVANVDFTVGKALGPAEFPPCDDTPGHNDDAAGPKPTTVYAVDGLNPRIAIAMRYTSDEVMLLAVQPGGSLPPEVKALTRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JI32</accession>
    <name>A0A2M9JI32_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Transport permease protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CG723_38945</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CB01635</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the ABC-2 integral membrane protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000029">
        <property type="protein sequence ID" value="PJN06520.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN06520">
        <property type="protein sequence ID" value="PJN06520"/>
        <property type="gene ID" value="CG723_38945"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046677">
        <property type="term" value="P:response to antibiotic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC_2_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000412">
        <property type="entry name" value="ABC_2_transport"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01061">
        <property type="entry name" value="ABC2_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006648">
        <property type="entry name" value="DrrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00164">
        <property type="entry name" value="ABC2TRNSPORT"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51012">
        <property type="entry name" value="ABC_TM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0046">Antibiotic resistance</keyword>
    <keyword evidence="8" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="30"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="65"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="108"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="144"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="177"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="229"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="domain" description="ABC2_membrane" evidence="9">
        <location>
            <begin position="14"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PJN06520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="254" mass="27009" checksum="BE2FACB783D5FFD7" modified="2018-04-25" version="1">MSTATLTRTSPNRAVLRTEARLFRREPAGLFWIVVFPSVLLVILGSIPSFREADKSLGGIRLVDAYVPVTVLLSMIMSGLQSMPPVITGYRERGILRRMSTTPVRPAALLGAQMGIHGIAALCSAVLSLAVGRIAYDVPLPKQAAGYLLALVLAVLVALALGALVSALSRTTKISNAIGSVVFFPMMFCAGVWLPVQAMPDALAHIVEYTPFGAAAQALGQAASGDWPAWSHLGVLAAWTVLLSAGASRWFRWE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JIK5</accession>
    <name>A0A2M9JIK5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CG723_38010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000027">
        <property type="protein sequence ID" value="PJN06673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN06673">
        <property type="protein sequence ID" value="PJN06673"/>
        <property type="gene ID" value="CG723_38010"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PJN06673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="255" mass="26526" checksum="0A409A849225D925" modified="2018-04-25" version="1">MMDSLHGTGVVVTGAGGGIGAALARRFAASGARVVVNDLDAGKAKAVADEIGATAVPGDASEIVPEALDALDGTVDVYCANAGLASGGTEDADEQIWADAWDVNVMAHVRAAKALLPGWLERGSGRFVSTVSAAGLLTMVGAAPYSVTKHGAYAFAEWLSLTYRHRGLKVHAICPQGVRTDMLTASGSAGELVLAPTAIEPEDVADALFAGMEEDRFLILPHPEVAGYYAARAATPDRWLSNMNHIQQKWEAAQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JJ88</accession>
    <name>A0A2M9JJ88_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_36840</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000025">
        <property type="protein sequence ID" value="PJN06912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN06912">
        <property type="protein sequence ID" value="PJN06912"/>
        <property type="gene ID" value="CG723_36840"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="155"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN06912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="272" mass="28205" checksum="BDC74829E9942F6D" modified="2018-04-25" version="1">MPFALLITTAAATAVGAAALHTVHGLRRQITELRDELAHDRAIGAGRGVPAARTTPDTEEIRAAVADALAEERERELAEARAFWAAQEARDASDAPSMLGGALGLGDDLFMPRQADFAGLEPGLAAGLEPVVEPADAGADEFAGESAELAAARRRHPSHPDFVPVQSPVSGGSSDHERTVACLEELADARTALADVRPGPLGTLDVYVFVDGTTLCMTPGHRETAEQLAAALREGESPVLLGGSGVSGAYALTFACGHENVYILADRVIASV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JJF3</accession>
    <name>A0A2M9JJF3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Short-chain dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CG723_36570</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000024">
        <property type="protein sequence ID" value="PJN06998.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN06998">
        <property type="protein sequence ID" value="PJN06998"/>
        <property type="gene ID" value="CG723_36570"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PJN06998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="252" mass="25934" checksum="3F12BF812D84FA70" modified="2018-04-25" version="1">MTGMQRFTDQVAVVTGAAVGIGAATAARLASEGAAVVLSDIDAERGERTAAELREQGARASFVRADVADAADWERVLDTAHAYGPVRVLVSNAYTVELAPAGEMTQASWERQVAVNLTGGFLGFKAVQPDMSEHGGSVVYTSSVHAHMGLPGRPAYAATKGAVLSLCSQLAVEYGPSIRVNAVLPGPILTGAWDGIDEESRARSVAETAARRFGTPEDVAAAIAFLASAEAGFVTGTSLLVDGGWSVVKASS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JJG8</accession>
    <name>A0A2M9JJG8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_36235</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000024">
        <property type="protein sequence ID" value="PJN07018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN07018">
        <property type="protein sequence ID" value="PJN07018"/>
        <property type="gene ID" value="CG723_36235"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13581">
        <property type="entry name" value="HATPase_c_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HATPase_c" evidence="2">
        <location>
            <begin position="77"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="18"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN07018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="202" mass="22272" checksum="4EC64F6742C9A280" modified="2018-04-25" version="1">MTSHRGCFARFYRRRLEESGRKGAADPAQGEGQSPEGAGTSWVARNRALWSRTLEPVRPLDRPRARATAWDASWPIPRELTSVRQARRLVTAQLDDWDLEGLADTAELLVSELVTNALRHTRGPLRLNLQVRGSRLRCEVEDTDPAGPVRRVVDTDAEGGRGTELLDLLADAWGSTCTPTGKTTWCEMLTQTPSPKGSPASD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JJJ2</accession>
    <name>A0A2M9JJJ2_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">50S ribosomal protein L28</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4 5" type="primary">rpmB</name>
        <name evidence="5" type="ORF">CG723_35530</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CB01635</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the bacterial ribosomal protein bL28 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000023">
        <property type="protein sequence ID" value="PJN07045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN07045">
        <property type="protein sequence ID" value="PJN07045"/>
        <property type="gene ID" value="CG723_35530"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.170.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00373">
        <property type="entry name" value="Ribosomal_L28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034704">
        <property type="entry name" value="L28p-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026569">
        <property type="entry name" value="Ribo_L28/L24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037147">
        <property type="entry name" value="Ribo_L28/L24_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001383">
        <property type="entry name" value="Ribosomal_L28"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13528">
        <property type="entry name" value="PTHR13528"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00830">
        <property type="entry name" value="Ribosomal_L28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143800">
        <property type="entry name" value="SSF143800"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00009">
        <property type="entry name" value="L28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00373"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PJN07045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="78" mass="8803" checksum="E668998EBC0B63AB" modified="2018-04-25" version="1">MSAHCMLTGAAPGFGNRISHSHRRTSRRFDPNVQRKRYWLPSEGRHVQLRLSARAIRTVDAIGVEAAVARIRARGVRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JJJ3</accession>
    <name>A0A2M9JJJ3_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">50S ribosomal protein L33</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4 5" type="primary">rpmG</name>
        <name evidence="5" type="ORF">CG723_35535</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CB01635</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the bacterial ribosomal protein bL33 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000023">
        <property type="protein sequence ID" value="PJN07046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN07046">
        <property type="protein sequence ID" value="PJN07046"/>
        <property type="gene ID" value="CG723_35535"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.28.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00294">
        <property type="entry name" value="Ribosomal_L33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038584">
        <property type="entry name" value="L33_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001705">
        <property type="entry name" value="Ribosomal_L33"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018264">
        <property type="entry name" value="Ribosomal_L33_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011332">
        <property type="entry name" value="Ribosomal_zn-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00471">
        <property type="entry name" value="Ribosomal_L33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57829">
        <property type="entry name" value="SSF57829"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01023">
        <property type="entry name" value="rpmG_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00582">
        <property type="entry name" value="RIBOSOMAL_L33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PJN07046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="54" mass="6505" checksum="FF98629313357E3F" modified="2018-04-25" version="1">MARNELRPVIKLRSTAGTGHTYVTRKNRRNDPDRVTLRKYDPVARRHVDFREER</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JJQ4</accession>
    <name>A0A2M9JJQ4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">N-acetylglutamate synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_35825</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000023">
        <property type="protein sequence ID" value="PJN07101.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN07101">
        <property type="protein sequence ID" value="PJN07101"/>
        <property type="gene ID" value="CG723_35825"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="13"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN07101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="180" mass="20107" checksum="7EC3DC8F0D41BABB" modified="2018-04-25" version="1">MPAQLPAVTAKAVTVRRARTADVPSVRRLLDAYSREGILLDKATVTLYEDIQEFWVAERDDNAEVVGCGALHVMWEDLAEVRTLAVNPVVRGAGVGHQLLQKLLQTARWIGVRRVFCLTFEVEFFANHGFVEIGEAPVDTIDTDVYSELLRSYDEGVAEFLGLERVKPNTLGNSRMLLHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JJS1</accession>
    <name>A0A2M9JJS1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CG723_35385</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000023">
        <property type="protein sequence ID" value="PJN07135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN07135">
        <property type="protein sequence ID" value="PJN07135"/>
        <property type="gene ID" value="CG723_35385"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025338">
        <property type="entry name" value="DUF4244"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14029">
        <property type="entry name" value="DUF4244"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PJN07135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="67" mass="7193" checksum="BED970543B7AE836" modified="2018-04-25" version="1">MYGVMRARAGMWVRRMRAARRDAGMVTSEYAMGLIAAVGFAGLLLKVLTSGQVQAALQGIVERALHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JJV8</accession>
    <name>A0A2M9JJV8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_34790</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000022">
        <property type="protein sequence ID" value="PJN07165.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN07165">
        <property type="protein sequence ID" value="PJN07165"/>
        <property type="gene ID" value="CG723_34790"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014611690" evidence="2">
        <location>
            <begin position="37"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="155"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="181"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="214"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="294"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN07165.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="339" mass="33498" checksum="62B94A197B3A99F3" modified="2018-04-25" version="1">MSSPTATPAPPSPARRMAAVALLVPMLVALALWAFAWPGARTAPRDLPLGVAGPAAAAAPVEQQLRSHKGAFEIHRYADEAAARAAITDRTVYGAVVATPQGPKLLTATAASPVVAQLLQQAVTAEAPKDTQVPTVDVVAAPAGDPRGAVLSSSVLPLAIAGVAGGAVVTLLGLRGWRAAGALVVASSLVGVVAAALTHSWLGVLTGNWWAEAGVLGLSALAVGGTVAGLSALFGPSGIGVGSLLMVLLGNPFSGVSSAPQLLPEPVGRIGQLLPPGAGGTLLRSVSYFDGARAMTPAITLAAWAGLGLVCVLLGGLRKKRGAGEVAGEPTAREAVAVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JK10</accession>
    <name>A0A2M9JK10_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">tRNA_edit domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_35050</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000022">
        <property type="protein sequence ID" value="PJN07209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN07209">
        <property type="protein sequence ID" value="PJN07209"/>
        <property type="gene ID" value="CG723_35050"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002161">
        <property type="term" value="F:aminoacyl-tRNA editing activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.960.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036754">
        <property type="entry name" value="YbaK/aa-tRNA-synt-asso_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007214">
        <property type="entry name" value="YbaK/aa-tRNA-synth-assoc-dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04073">
        <property type="entry name" value="tRNA_edit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55826">
        <property type="entry name" value="SSF55826"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="tRNA_edit" evidence="1">
        <location>
            <begin position="55"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN07209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="185" mass="19487" checksum="EA61957EDEE79D3F" modified="2018-04-25" version="1">MRAPIGDFDRVRPAPEAFDLLTDPVADAVRNWHGTVPAEQLIHVDTEPEWADTATFVEHYGPELLQDSANCVVVAGKRGGETTLAACLVLSGTRVDVNGAVRRQLGARKASFAPMETATGATGMEYGGITPIGLPADWPLLVDAAVVDRPHVLIGSGTRRGKLIVPGKAFLDLPGAVVLEGLGMN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JK49</accession>
    <name>A0A2M9JK49_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Pyridoxamine 5-phosphate oxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_35230</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000022">
        <property type="protein sequence ID" value="PJN07244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN07244">
        <property type="protein sequence ID" value="PJN07244"/>
        <property type="gene ID" value="CG723_35230"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011576">
        <property type="entry name" value="Pyridox_Oxase_put"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01243">
        <property type="entry name" value="Putative_PNPOx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Putative_PNPOx" evidence="1">
        <location>
            <begin position="15"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN07244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="155" mass="17617" checksum="462FEDDCAF595DDC" modified="2018-04-25" version="1">MAVTQRRGRKIMMTPAELDEFLGSQRTCRVATVSPDGSPHVSTLWFVWDGARLWLYSITRSRRWADLLKDPRIAVVIDAGEEYGELRGAELSGMVEFVGESPRTGEAVPELNVPERLFARKNFAMDEMVHDGRHAWARLTPDKIASWDFRKLASL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JKH6</accession>
    <name>A0A2M9JKH6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Amino acid permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CG723_34560</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CB01635</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000021">
        <property type="protein sequence ID" value="PJN07375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN07375">
        <property type="protein sequence ID" value="PJN07375"/>
        <property type="gene ID" value="CG723_34560"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="34"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="64"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="108"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="154"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="188"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="227"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="266"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="316"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="362"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="389"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="436"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="470"/>
            <end position="492"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PJN07375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="521" mass="55631" checksum="AF0D31A82254B3E4" modified="2018-04-25" version="1">MSQDESTQETRSGDDAELAEFGYRPELKRTLGNFHTFAAGISYISILTGTFQLFYFGFANGGPAYWWSWPMVFGGQFTVALCFAELAARYPVAGSVYNWAKKVGNPHIGWLAGWMMLLASVVSIAAVALAYQLTLPQISSAFQFIGDGTGPYDVATNAVVLASVLILFTTLVNAFGVKLMATINTAGVFLELIATVVLIVLFAVHIVRGPQVVTHTAGAGHGQPFGYLSAFLVASLASAYVMYGFDTAASLGEESLDPTRGAPRAIIRAIVASFVLGGLILLLALMSVSSLTGEKLSTDGLQYVVLDVLGPTAGKAMLWCVLIAVTVCALAVHTAAIRLAFAMSRDNNLPASSVLGRVSPRFKTPVVPAVVIGVLALAILVVNIRQPQIFTVVTSIGIIMIYLAYLLVTAPMLVARLRGRWQPAGDGKFSLGRWGLPVNIIAVLWGGAMTLNLIWPRAAVYNAAAPYHWYLRWGAVLFIGVIAGGGFAYYWVVQRHRTGVLAEHAAEPARTAAPLEEVTTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JKU4</accession>
    <name>A0A2M9JKU4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Maltose acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CG723_33850</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CB01635</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the transferase hexapeptide repeat family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000020">
        <property type="protein sequence ID" value="PJN07478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN07478">
        <property type="protein sequence ID" value="PJN07478"/>
        <property type="gene ID" value="CG723_33850"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016407">
        <property type="term" value="F:acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001451">
        <property type="entry name" value="Hexapep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018357">
        <property type="entry name" value="Hexapep_transf_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024688">
        <property type="entry name" value="Mac_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00132">
        <property type="entry name" value="Hexapep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12464">
        <property type="entry name" value="Mac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01266">
        <property type="entry name" value="Mac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="SSF51161"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00101">
        <property type="entry name" value="HEXAPEP_TRANSFERASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Mac" evidence="4">
        <location>
            <begin position="15"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PJN07478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="194" mass="20703" checksum="097C153893477D05" modified="2018-04-25" version="1">MTTTDSFADDPRTNLERMLAGDLYIADDPEIARRQRRAMQLAARYQAAFVVDADKARPILADLLDSVGEGVEVRPPLFVDYGSNIAIGARTFVNYHLTALDVARIAIGEDCQIGPNVQLLTPTHPVEPQPRRDKLEAALPITIGDNVWLGGGVIVCPGVTIGDNSVIGAGAVVTKDIPANVVAVGNPARPVRTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JKV7</accession>
    <name>A0A2M9JKV7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Acetyl-CoA acetyltransferase</fullName>
            <ecNumber evidence="1">2.3.1.9</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CG723_34050</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.9" evidence="1"/>
    <dbReference type="EMBL" id="NNBL01000020">
        <property type="protein sequence ID" value="PJN07510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN07510">
        <property type="protein sequence ID" value="PJN07510"/>
        <property type="gene ID" value="CG723_34050"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003985">
        <property type="term" value="F:acetyl-CoA C-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002155">
        <property type="entry name" value="Thiolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000429">
        <property type="entry name" value="Ac-CoA_Ac_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PJN07510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="400" mass="42538" checksum="43AFE2F3F0F238DF" modified="2018-04-25" version="1">MSSTVSGRVSGGVNKEPVAVVGIGQTKHVAARKDVSIAGLVREAARRALEDAQLTWADIDAVVIGKAPDFFEGVMMPELYLADALGAVGKPMLRVHTAGSVGGSTALVATNLVASRVHRTVLTLAFEKQSESNAMWGLSLPIPFTQPLLAGAGGFFAPHVRAYMRRTGAPDHVGSLVAYKDRRNALKNPYAHLHEHGITLEKVQSSPMLWDPVRYSETCPSSDGACAMILTDRAGAARSPQPPAWMHGGAMRSEPTMFAGKDFVSPQAGKDCAADVYRQAGIGDPRREIDAVEMYVPFSWYEPMWLENLGFAAEGEGWKLTESGVTELDGDLPVNMSGGVLSTNPIGASGMIRFAEAALQVRGQAGEHQVDGARKVLGHAYGGGSQFFSMWLVGAHPPTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JL79</accession>
    <name>A0A2M9JL79_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 7 8">DNA replication and repair protein RecF</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">recF</name>
        <name evidence="10" type="ORF">CG723_33225</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CB01635</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6 7 8">The RecF protein is involved in DNA metabolism; it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7 8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7 8">Belongs to the RecF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000019">
        <property type="protein sequence ID" value="PJN07629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN07629">
        <property type="protein sequence ID" value="PJN07629"/>
        <property type="gene ID" value="CG723_33225"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009432">
        <property type="term" value="P:SOS response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00365">
        <property type="entry name" value="RecF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001238">
        <property type="entry name" value="DNA-binding_RecF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018078">
        <property type="entry name" value="DNA-binding_RecF_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003395">
        <property type="entry name" value="RecF/RecN/SMC_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042174">
        <property type="entry name" value="RecF_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32182:SF0">
        <property type="entry name" value="PTHR32182:SF0"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02463">
        <property type="entry name" value="SMC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00611">
        <property type="entry name" value="recf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00617">
        <property type="entry name" value="RECF_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00618">
        <property type="entry name" value="RECF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 8" id="KW-0227">DNA damage</keyword>
    <keyword evidence="7 8" id="KW-0234">DNA repair</keyword>
    <keyword evidence="7 8" id="KW-0235">DNA replication</keyword>
    <keyword evidence="7 8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4 7 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 8" id="KW-0742">SOS response</keyword>
    <feature type="domain" description="SMC_N" evidence="9">
        <location>
            <begin position="3"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="30"/>
            <end position="37"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00020170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00025401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02463"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PJN07629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="374" mass="40971" checksum="BD13CE365C755BEF" modified="2018-04-25" version="1">MHVTHLSLADFRSYARVEVPLDPGVTAFVGPNGQGKTNLVEAVGYLATLGSHRVSSDAPLVRMGAERAVIRAAVRQGERQQLIELELNPGKANRARINRSSQVRPRDVLGIVRTVLFAPEDLALVKGDPGERRRFLDELITARSPRMAGVRSDYDRVLKQRNTLLKSAALARRHGGRSMDLSTLEVWDQHLARVAAELLAQRFDLIATLQPLADKAYEQLAPGGGPLALDYKPSSPEIDGHAREELYEQLMAALEAARKQEIERGVTLVGPHRDDLILKLGQLPAKGYASHGESWSYALALRLASYDLLRAEGNEPVLVLDDVFAELDARRRERLAELVAPGEQVLVTAAVDDDVPGVLAGTRYAVSEGTVERV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JL80</accession>
    <name>A0A2M9JL80_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">DNA gyrase subunit B</fullName>
            <ecNumber evidence="10">5.6.2.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10 12" type="primary">gyrB</name>
        <name evidence="12" type="ORF">CG723_33235</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">CB01635</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP-dependent breakage, passage and rejoining of double-stranded DNA.</text>
            <dbReference type="EC" id="5.6.2.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="10">Heterotetramer, composed of two GyrA and two GyrB chains. In the heterotetramer, GyrA contains the active site tyrosine that forms a transient covalent intermediate with DNA, while GyrB binds cofactors and catalyzes ATP hydrolysis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="miscellaneous">
        <text evidence="10">Few gyrases are as efficient as E.coli at forming negative supercoils. Not all organisms have 2 type II topoisomerases; in organisms with a single type II topoisomerase this enzyme also has to decatenate newly replicated chromosomes.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the type II topoisomerase GyrB family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the type II topoisomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.2" evidence="10"/>
    <dbReference type="EMBL" id="NNBL01000019">
        <property type="protein sequence ID" value="PJN07631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN07631">
        <property type="protein sequence ID" value="PJN07631"/>
        <property type="gene ID" value="CG723_33235"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034335">
        <property type="term" value="F:DNA negative supercoiling activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006265">
        <property type="term" value="P:DNA topological change"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006261">
        <property type="term" value="P:DNA-templated DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03366">
        <property type="entry name" value="TOPRIM_TopoIIA_GyrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.670">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01898">
        <property type="entry name" value="GyrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002288">
        <property type="entry name" value="DNA_gyrase_B_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011557">
        <property type="entry name" value="GyrB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001241">
        <property type="entry name" value="Topo_IIA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013760">
        <property type="entry name" value="Topo_IIA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013759">
        <property type="entry name" value="Topo_IIA_B_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013506">
        <property type="entry name" value="Topo_IIA_bsu_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018522">
        <property type="entry name" value="TopoIIA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006171">
        <property type="entry name" value="TOPRIM_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034160">
        <property type="entry name" value="TOPRIM_GyrB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00204">
        <property type="entry name" value="DNA_gyraseB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00986">
        <property type="entry name" value="DNA_gyraseB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01751">
        <property type="entry name" value="Toprim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00433">
        <property type="entry name" value="TOP2c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56719">
        <property type="entry name" value="SSF56719"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01059">
        <property type="entry name" value="gyrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00177">
        <property type="entry name" value="TOPOISOMERASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50880">
        <property type="entry name" value="TOPRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 10 12" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 10" id="KW-0799">Topoisomerase</keyword>
    <feature type="domain" description="Toprim" evidence="11">
        <location>
            <begin position="477"/>
            <end position="591"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PJN07631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="698" mass="76818" checksum="60F2AE97397EF754" modified="2018-04-25" version="1">MLCQKGRFVADSGNPNENIPSTAADAVGQAPAEASQSSGEVTSAYDASAITVLEGLDAVRKRPGMYIGSTGERGLHHLVQEVVDNSVDEALAGHADTIDVTILHDGGVRVVDNGRGIPVGIVPSEGKPALEVVLTVLHAGGKFGGGGYAVSGGLHGVGVSVVNALSMKVAVEVKTDGHRWTQDYKLGVPTAPLVQHEATDEHGTSVTFWADPDIFETTEYSFETLSRRFQEMAFLNKGLRIKLTDERESAKAVAGADEAGADEKPEVKAVEYHYEGGIVDFVKYLNSRKGDVVHPSVIDLEAEDKDKLLSLEVAMQWNSSYTEGVYSFANIIHTHEGGTHEEGFRAALTSLINKYARDKKLLREKDDNLTGDDIREGLTAIISVKLSEPQFEGQTKTKLGNTEVKTFVQKVVYEHLNDWLDRNPVEAADIIRKGIQAATARVAARKARDLTRRKGLLESASLPGKLSDCQSNDPTKCEIFIVEGDSAGGSAKSGRNPQYQAILPIRGKILNVEKARIDKILQNQEIQALISAFGTGVHEDFDIEKLRYHKIILMADADVDGQHINTLLLTFLFRFMRPLVEAGYVFLSRPPLYKIKWGREDFEYAYSDRERDALTELGRQQGKRIREDSIQRFKGLGEMNAEELRITTMDIEHRVLGQVTLDDAAQADDLFSVLMGEDVEARRSFIQRNAKDVRFLDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JL93</accession>
    <name>A0A2M9JL93_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Putative membrane protein insertion efficiency factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_33190</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Could be involved in insertion of integral membrane proteins into the membrane.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0161 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000019">
        <property type="protein sequence ID" value="PJN07622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN07622">
        <property type="protein sequence ID" value="PJN07622"/>
        <property type="gene ID" value="CG723_33190"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00386">
        <property type="entry name" value="UPF0161_YidD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002696">
        <property type="entry name" value="Membr_insert_effic_factor"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33383">
        <property type="entry name" value="PTHR33383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01809">
        <property type="entry name" value="YidD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01234">
        <property type="entry name" value="Haemolytic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00278">
        <property type="entry name" value="TIGR00278"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="80"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="99"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN07622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="119" mass="13102" checksum="E29A2E7ECA55E9CD" modified="2018-04-25" version="1">MKYPLLALIKLYQWTISPLLGPVCKYYPSCSHYGFTAIDRHGAIKGTALTAWRILRCNPWSLGGVDHVPPRKRPRWHEMLRNAWRERKGGPSAAGAPSECGHTSPSSPAAETPSHAQGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JLX7</accession>
    <name>A0A2M9JLX7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">LysR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_31185</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LysR transcriptional regulatory family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000017">
        <property type="protein sequence ID" value="PJN07863.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN07863">
        <property type="protein sequence ID" value="PJN07863"/>
        <property type="gene ID" value="CG723_31185"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08417">
        <property type="entry name" value="PBP2_Nitroaromatics_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005119">
        <property type="entry name" value="LysR_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000847">
        <property type="entry name" value="Tscrpt_reg_HTH_LysR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037402">
        <property type="entry name" value="YidZ_PBP2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00126">
        <property type="entry name" value="HTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03466">
        <property type="entry name" value="LysR_substrate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00039">
        <property type="entry name" value="HTHLYSR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50931">
        <property type="entry name" value="HTH_LYSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH lysR-type" evidence="2">
        <location>
            <begin position="14"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN07863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="318" mass="34849" checksum="1C10FDCE949777DC" modified="2018-04-25" version="1">MSPRQSRPTHLANLDLNLLVTLRALLRERNVTRAARNLGVTQPAVSAALSRLRRHFGDELLARVQGAYVLTPLAAQLAGQVETVCAAAERLFATGRAFDPDTTEREFTLLMADYQATVLGPALSRLFDREAPHAALHVQLIRETLGSGAGDAIRLVDAMVSPPLGHFRTPGVHSAPLFQDRWVCLVSADHPLCGTESFGIEDLARLPWVVPYHRDEGYPSAAPATRQLSTLGIRPRIAVRVESYRAVPDFISGTRRVALVPERLAAPLRSAHGLRTLACPVSLDPLEEHLWWDASHDEDPAHSWLRDLVARAAARLGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-05-25" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JLZ6</accession>
    <name>A0A2M9JLZ6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Heat-shock protein Hsp20</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CG723_31285</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CB01635</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the small heat shock protein (HSP20) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000017">
        <property type="protein sequence ID" value="PJN07879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN07879">
        <property type="protein sequence ID" value="PJN07879"/>
        <property type="gene ID" value="CG723_31285"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002068">
        <property type="entry name" value="A-crystallin/Hsp20_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008978">
        <property type="entry name" value="HSP20-like_chaperone"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00011">
        <property type="entry name" value="HSP20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49764">
        <property type="entry name" value="SSF49764"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01031">
        <property type="entry name" value="SHSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SHSP" evidence="3">
        <location>
            <begin position="24"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS01031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PJN07879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="144" mass="16052" checksum="102D19137A292FE7" modified="2018-04-25" version="1">MLMRTDSFRELDRLAQQLTGVTGTWSRPSAMPMDAYREGEEYVIALDLPGVAKDAIDIDVERNMLTVRAERRPATKADDVQMELSERPLGVFSRQLVLADTLDTEHITADYEAGVLTLRIPIAERAKPRKIAIGGESDHKQISG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JM91</accession>
    <name>A0A2M9JM91_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Two-component sensor histidine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_30185</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000016">
        <property type="protein sequence ID" value="PJN07972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN07972">
        <property type="protein sequence ID" value="PJN07972"/>
        <property type="gene ID" value="CG723_30185"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011712">
        <property type="entry name" value="Sig_transdc_His_kin_sub3_dim/P"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07730">
        <property type="entry name" value="HisKA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="35"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="75"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="99"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="141"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="165"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="domain" description="HATPase_c" evidence="2">
        <location>
            <begin position="329"/>
            <end position="427"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN07972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="430" mass="45594" checksum="6F3A7E9F0B10DF30" modified="2018-04-25" version="1">MNSVTTEDLGAMGPLVARFGRAGERLRRADQARPWVLDTAVVVLVFLVFCLPDLLHRGVGDSDGPRRFRLSFTQLPTVGMLALQAGLVLPLLWRRRSPAAAFGGVTAVFVLQWSLGAALRADVALFVALYSLALHGRLRQLPWACAVMAGALGLVAARVSSAVSLWDALFFLLSTATAALALGLMIRIRRAQLAGLRDRAARLEIERDQRGRLAVAAERTRVAREMHDIVGHNLSVIITLADAGAYATAVAPERGTEALHLIGDTGRQALGELRRLLGVLREADGPRTEPELSPQPGLADIDALCEGVRAAGLKVIYRTAGDIDALDSGVQLTVYRIVQEALTNALKHAGADARANLAIVVEDKRLTITVQDSGPAAPAARRGPANEEGHGLVGMRERAALYGGHINAGPAGAGWAVRAELNLAPQGGAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JMT4</accession>
    <name>A0A2M9JMT4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">ABC transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CG723_29710</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CB01635</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC-2 integral membrane protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000015">
        <property type="protein sequence ID" value="PJN08183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08183">
        <property type="protein sequence ID" value="PJN08183"/>
        <property type="gene ID" value="CG723_29710"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046677">
        <property type="term" value="P:response to antibiotic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000412">
        <property type="entry name" value="ABC_2_transport"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006648">
        <property type="entry name" value="DrrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0046">Antibiotic resistance</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="18"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="48"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="98"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="133"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="165"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="221"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PJN08183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="246" mass="26325" checksum="6621C69A2BE7F3AD" modified="2018-04-25" version="1">MNSLIKLEITRALRNKKFLFFSVVYPSVLFLLIAGSSDSSTMVDGTGLNLAAFMMVSMASFGALTAVLMGNSERIAKERESGWVRQLRLTTLPGRGYVLAKTASAAVVSLPSIVVVFVVAAVTKGVRLDAWQWLALVVAIWAGSLCFAALGVAIGYLATGDAVRPITMIVYFGLSILGGLWFPSTGFPQWLSDIASWLPTHAYAALGQAIELGNAPHAKDVTLIVAYFLVFAGGAAWLYRKDTLKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JMY8</accession>
    <name>A0A2M9JMY8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="10">DEAD/DEAH box helicase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CG723_29885</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000015">
        <property type="protein sequence ID" value="PJN08215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08215">
        <property type="protein sequence ID" value="PJN08215"/>
        <property type="gene ID" value="CG723_29885"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 10" id="KW-0347">Helicase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Q_MOTIF" evidence="9">
        <location>
            <begin position="82"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="7">
        <location>
            <begin position="113"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="8">
        <location>
            <begin position="322"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="496"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="617"/>
            <end position="821"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="5">
        <location>
            <begin position="82"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="17"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="49"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="523"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="647"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="676"/>
            <end position="693"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="703"/>
            <end position="717"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="726"/>
            <end position="746"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="754"/>
            <end position="768"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="803"/>
            <end position="821"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PJN08215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="821" mass="88329" checksum="F10988A13FC257A1" modified="2018-04-25" version="1">MPGRWPDRLRPDSPPGGTSHDVRHEEGPSAARALERRQWSRVTRPARLSLATGDQSARSRPPRSPRTASHRRGNTLTTQQLSTFRELGILPETAEALEAVGIINPFPIQEMTLPVALSGTDVIGQAKTGTGKTLGFGLPLLERVTVPADVEAGRAQPEQLTDAPQALVVVPTRELCQQVTNDLLTAGKVRNVRVLAIYGGRAYEPQVEALKKGIDVVVGTPGRLLDLAGQKKLNLKHIKSLVLDEADEMLDLGFLPDVEKIINMLPAKRQTMLFSATMPGAVIGLARRYMSQPTHIRATSPDGEGATVANTSQHVYRAHNMDKPEMVARILQADGRGLAMIFCRTKRTAADIADQLQKRGFASGAVHGDLGQGAREQALRAFRNGKVDVLVCTDVAARGIDVEGVTHVINYQSPEDEKTYLHRIGRTGRAGAKGIAITLVDWDDIPRWQLINKALDLKFPDPVETYSSSPHLYEELNIPAGTKGVLPRAERTRAGLAAEEVEDLGETGGRGGRGGRGGRTAAPAPVEEREREPRPARTTPRRRRRIRNGEPVAAPTANEPKTAPAEAVAASEAVDATVVEPRTPRRRRRTRTGAAPEAVVETAAVVTAEAVADTVEAPEAVETKPKRTRKAAVPKAAASEEAAETVEATVPRPRRRTRKAAEAVVDTVEAVESVEAPAETKPKRTRKAAPKAEAVADTVEATEVAEAKPKRTRKTAAPKATADAVVAEEAETKPRRRTRKTAEAVADTVEAVEAPAETKPKRTRKAAAPKATVDAAAEVTETKPKRTRKAAAPKATADASAEEAPAKPRRRTRKTAEPTES</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JN34</accession>
    <name>A0A2M9JN34_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CG723_29835</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000015">
        <property type="protein sequence ID" value="PJN08265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08265">
        <property type="protein sequence ID" value="PJN08265"/>
        <property type="gene ID" value="CG723_29835"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PJN08265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="235" mass="24205" checksum="3E5BFA31933CDEC3" modified="2018-04-25" version="1">MVGVMCLGLAACSSEDPDAGTNGVAKLTAPKIQSRTVKAAQGAGAVHLSGTVVSSGHSYKIDMRLKDEGGTGSVTTAGRTFQLLRVKEHLFLKADADFWTHQGSKGSGGTAQGDTAAADKLDGKYVKVPQGDPAYKRLSGFTVKGALLDGLLTLHGKVEKGDRGSAGGVRTVELTGDKGAGGTLDVSLEGTPYPLRLERAGGAGTLQLTDWGKDFTLREPGKGEMVDYGAQLPTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JN44</accession>
    <name>A0A2M9JN44_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alpha/beta hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_28145</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000014">
        <property type="protein sequence ID" value="PJN08279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08279">
        <property type="protein sequence ID" value="PJN08279"/>
        <property type="gene ID" value="CG723_28145"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000639">
        <property type="entry name" value="Epox_hydrolase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00111">
        <property type="entry name" value="ABHYDROLASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00412">
        <property type="entry name" value="EPOXHYDRLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="48"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN08279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="316" mass="35107" checksum="000F6A551F1E2773" modified="2018-04-25" version="1">MTDPATPSAQPASVVRIGVPGGGELTHRDVAANGARFHIAEMGDGPLVLLLHGFPQFWWTWRHQMVALADAGFRAVAMDLRGVGGSDRTPRGYDPANLALDITGVVRSLGEPDAALVGHDLGGYLAWTAAVMRPKLVRRLVVSSMPHPRRWRSAMLSDVKQTAAGSYVWGFQRPWVPERQLVADDGALVGRLIRDWSGPRLPDDEAVDVYRRAMCIPSTAHCSVEPYRWMVRSMARPDGIQFNRRMKRPVRVPTLHLHGSLDPVMRTRSAAGSGEYVEAPYRWRLFDGLGHFPHEEDPVAFSSELVSWLKDPEPDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JN64</accession>
    <name>A0A2M9JN64_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Lipopolysaccharide biosynthesis protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_28375</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000014">
        <property type="protein sequence ID" value="PJN08313.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08313">
        <property type="protein sequence ID" value="PJN08313"/>
        <property type="gene ID" value="CG723_28375"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="27"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="175"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="201"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN08313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="220" mass="22167" checksum="06014A0CE9D23DEE" modified="2018-04-25" version="1">MTDAPHRRVSPAGPLARTAARVKRLPLWPLIVAGVLLGGLAGGLYGVLKTPQYSATSYVIAVPDEMSDPSTALGFAQAYGRVATQIAVLGDAQERAGVSVKVLQASVRAETSPDAPMVAVSATSAQPRKAADMANAVARALTADANRTQAGTKVKLLQFSRAVKPTAPSSASPKVTALVGAGAGGLLGGLAMLVRPRREPAETAATVPGPAAAADLQGSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JNE9</accession>
    <name>A0A2M9JNE9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Aspartate aminotransferase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_28585</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000014">
        <property type="protein sequence ID" value="PJN08347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08347">
        <property type="protein sequence ID" value="PJN08347"/>
        <property type="gene ID" value="CG723_28585"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044249">
        <property type="term" value="P:cellular biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="CDD" id="cd00610">
        <property type="entry name" value="OAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005814">
        <property type="entry name" value="Aminotrans_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00202">
        <property type="entry name" value="Aminotran_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00600">
        <property type="entry name" value="AA_TRANSFER_CLASS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="1 2" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN08347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="451" mass="48340" checksum="8C2C9BA42618DB64" modified="2018-04-25" version="1">MTPQPNPQVGAAVKAADRAHVFHSWSAQELIDPLAVAGAEGSYFWDYDGNRYLDFTSGLVFTNIGYQHPKVVAAIQEQAASLTTFAPAFAVEARSEAARLIAERTPGDLDKIFFTNGGAEAVENATRMARLHTGRHKVLSAYRSYHGATSTAINLTGDPRRWPSDQGAAGVVHFWAPFLYRSPFYSETEQQECERALQHLEDTIVFEGPATIAAIILETVPGTAGIMTPPPGYLQGVRELCDRHGIVFILDEVMAGFGRTGKWFAADHYEVVPDLMTFAKGVNSGYVPLGGVAISGAIADTFGKRPYPGGLTYSGHPLACAAAVATINVMEEERVVENAAHLGETLIGPALRDLAERHPSVGEVRGLGMFWALELVKDKATREPLTPYNAAGAANAPMAAFGAAAKKNGLWPFINMNRTHVVPPCNVTEAEAKEGLAALDEALTVADGYTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JNP1</accession>
    <name>A0A2M9JNP1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_28505</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000014">
        <property type="protein sequence ID" value="PJN08489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08489">
        <property type="protein sequence ID" value="PJN08489"/>
        <property type="gene ID" value="CG723_28505"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019026">
        <property type="entry name" value="Peptidase_M64_IgA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09471">
        <property type="entry name" value="Peptidase_M64"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014663952" evidence="1">
        <location>
            <begin position="35"/>
            <end position="449"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN08489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="449" mass="47668" checksum="49A5384E66D312B7" modified="2018-04-25" version="1">MPKSPRRPLPAALLAGVLAAAALGGAGLAGHADAAEAAGGSDTGTRTVEYFADSHGGGRHVQVPAAVPAEIRRDKRAPATAAPDGEVTALQKTGPSEGRLDLVIMGDGYTADQQEDFRQDAESKLASIFAIEPYKSYKGLFNFWLVNAVSNESGVSGDPTQDVVKDTALSSYFFCDDVERLLCIDEKKVDSYAQQAPDSDIVFVVSNATKYGGAGYSGVQSTAGHTGIATMSSDNDRSYLIGAHELGHSIGLLADEYQYDGYGRYPGAEPVEPNTSIQTADGMSGAKAKWYRWLGESDPAGGTVGTYEGGGYYEYGIYRPTQNSIMRALDTEQFNLVGREAMIAGFYRDADVLTARTPTARTLRPQDHIRVDLAPLAKGLSDVRVHWYVDGVEVRRAAAEHTVTGKELGARKGTHTITATAVDSSASLRDPAAIRAASNSVSWTVKTGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JNS8</accession>
    <name>A0A2M9JNS8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Thioesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CG723_27470</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CB01635</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the thioesterase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000013">
        <property type="protein sequence ID" value="PJN08522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08522">
        <property type="protein sequence ID" value="PJN08522"/>
        <property type="gene ID" value="CG723_27470"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012223">
        <property type="entry name" value="TEII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001031">
        <property type="entry name" value="Thioesterase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11487">
        <property type="entry name" value="PTHR11487"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00975">
        <property type="entry name" value="Thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioesterase" evidence="3">
        <location>
            <begin position="71"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PJN08522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="317" mass="34600" checksum="4D3D9B98CA0CB4EF" modified="2018-04-25" version="1">MGAAARPGRRPPGDPHLHRRQGLPPPVRVALTPARPSGRGPRPQQRQGDDVYGSRTATRPAGEDEAAAGLRLFCFAHAGGGSSFFHPWRRALGPGVDVRPVVLPGRERRARETSHTRMGPLVEGLVTELAPQLDLPYVLFGHSLGSIVAYETARALLERGSRPPLALLVSGRRGPFVPDHRRPVHTLPEDEFLAEVSRLGGTPSEVLRQRDLLRHFLPPLRADHEVNETYRPVPPPGPALTCPVFAFTGDADPLADPHAVARWREVTSGDFRLRVFPGDHFYLKGAPDDLMSALRAAMGSVHQGSSVLRRQVHKVAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JNV6</accession>
    <name>A0A2M9JNV6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GNAT family N-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_27635</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000013">
        <property type="protein sequence ID" value="PJN08552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08552">
        <property type="protein sequence ID" value="PJN08552"/>
        <property type="gene ID" value="CG723_27635"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="176"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN08552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="313" mass="34019" checksum="FDE5796C77808955" modified="2018-04-25" version="1">MLLRPTTDADLARVTDFIVEEPISWIPADRYRAELAEGMYRPQWSWIAEEDGDIVARALWWGQAASEHPVALDCLHVAPSVPDRAGLAADLLRAGHKAFGQAGAAQPPLYNLTLSNGWRDDPAVSAALAWRREAALAAGLTHEVERLRLEWTPGTGVPAESGRLTFEEAPDEEFLDAFRRVAEGSLDAETRQHLAAHGPSATARKELDFYLGCPGERAWWRLARTPDGAVAGFAIPSATPYNPNVGYLGVVPELRGRGYVDVLLAEITRSHAERGAELITATTDTGNAPMAAAFERAGYRNTQIRMLFSAPAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JNW0</accession>
    <name>A0A2M9JNW0_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">TauD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CG723_27645</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000013">
        <property type="protein sequence ID" value="PJN08554.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08554">
        <property type="protein sequence ID" value="PJN08554"/>
        <property type="gene ID" value="CG723_27645"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042098">
        <property type="entry name" value="TauD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003819">
        <property type="entry name" value="TauD/TfdA-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02668">
        <property type="entry name" value="TauD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TauD" evidence="3">
        <location>
            <begin position="30"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PJN08554.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="330" mass="36716" checksum="B18F0CC78867788E" modified="2018-04-25" version="1">MTIEVHDAVAVSPVWEGRSLPALVRCESPGGALPAWVSAHRDEVDALARKAGAVLLRGFDVRGAQDFRAVMDALSPQVLAYGERSSPRSQVSDGVYTSTEYPADQPILLHNEQSYTAKWPTRIVFFCERAATEGGRTPLADSRRILARLRPETVDRFERLGVRYVRNYLPGISLRWQEAFQTDRVEDVAAYCARADITPEWVDEDHLRTVQVRPAVRRHPVTGERSWFNHALFFHVTSLDPEVSAGLLEALDEEDLPYNTYYGDGSPIESETLAELRAAYAAETTGFDWQPGDVLVVENMLVAHAREPFVGPRRILTAMADAIDAGEVPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JP53</accession>
    <name>A0A2M9JP53_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Acyl-CoA dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CG723_26500</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CB01635</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000012">
        <property type="protein sequence ID" value="PJN08651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08651">
        <property type="protein sequence ID" value="PJN08651"/>
        <property type="gene ID" value="CG723_26500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016627">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="SSF47203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="SSF56645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA_dh_N" evidence="4">
        <location>
            <begin position="6"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_1" evidence="3">
        <location>
            <begin position="160"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PJN08651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="287" mass="30325" checksum="24F87D83052A9C09" modified="2018-04-25" version="1">MRFQLTDDQRALRDGVRDLLAGRFDRDALRTAVDTPGHLDRELWRALGDAGFFALCLPEADGGVGLGLPEAVLVFEEAGRVLLPGPLVATHLAAGTVPGAATGEAVVTAPAGELLPWRDASDVVQGDATGAVPLASVDPLTPLHKLPRPHAPRSPEAVLLTAAEQLGSATRTCELAVQYAREREQFGQPIGAFQAVKHLCAQMLVRAEPARAAVYAAAVTADPVEIAAAELLADEAAVRNARDCVQVHGGMGFTWEADVHLHLKRAWVRAGTGRTARETEEELAAAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JPB2</accession>
    <name>A0A2M9JPB2_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RNA polymerase sigma factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CG723_26940</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CB01635</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the sigma-70 factor family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000012">
        <property type="protein sequence ID" value="PJN08723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08723">
        <property type="protein sequence ID" value="PJN08723"/>
        <property type="gene ID" value="CG723_26940"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000943">
        <property type="entry name" value="RNA_pol_sigma70"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009042">
        <property type="entry name" value="RNA_pol_sigma70_r1_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007624">
        <property type="entry name" value="RNA_pol_sigma70_r3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007630">
        <property type="entry name" value="RNA_pol_sigma70_r4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00140">
        <property type="entry name" value="Sigma70_r1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04539">
        <property type="entry name" value="Sigma70_r3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04545">
        <property type="entry name" value="Sigma70_r4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00046">
        <property type="entry name" value="SIGMA70FCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00715">
        <property type="entry name" value="SIGMA70_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00716">
        <property type="entry name" value="SIGMA70_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0731">Sigma factor</keyword>
    <keyword evidence="4 5" id="KW-0804">Transcription</keyword>
    <keyword evidence="1 5" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="RNA_pol_sigma70" evidence="6">
        <location>
            <begin position="126"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="domain" description="RNA_pol_sigma70" evidence="7">
        <location>
            <begin position="295"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS00715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS00716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PJN08723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="334" mass="37217" checksum="D706E30DE8CEA67D" modified="2018-04-25" version="1">MATRAVARRKSAASGETDGARSVRAVGGEIADRDLVGMYLDEIARTPLLDAAKEVELSQTIEAGVYARQILDGEAESEAAGKASREELEALVAAGERAKDVFIKSNLRLVVAVARRYPRSGLPLLDLIQEGNAGLVRAVEKFDYRKGFKFSTYATWWIRQAITRSIADQSRTIRLPVHLVEELGRIRRVQREFNRKNGRDPEPEEIAAELDSKPARVVDVLDWARDPVSLNMPVDDEGDTQFGDLLEDTSAVSPEQSVLTLLRSEELDDLIGRLDQRTASIIKMRYGIDDGRERTLTEVGKEHGLTRERIRQIEKHALLELKKLARDTGFDAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JPH2</accession>
    <name>A0A2M9JPH2_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">SSD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CG723_27125</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CB01635</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000012">
        <property type="protein sequence ID" value="PJN08756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08756">
        <property type="protein sequence ID" value="PJN08756"/>
        <property type="gene ID" value="CG723_27125"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004869">
        <property type="entry name" value="MMPL_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000731">
        <property type="entry name" value="SSD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03176">
        <property type="entry name" value="MMPL"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50156">
        <property type="entry name" value="SSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014702586" description="SSD domain-containing protein" evidence="7">
        <location>
            <begin position="35"/>
            <end position="735"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="180"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="207"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="231"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="272"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="304"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="368"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="524"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="555"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="594"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="636"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="667"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="domain" description="SSD" evidence="8">
        <location>
            <begin position="197"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PJN08756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="735" mass="76633" checksum="6E78E63F6E025F99" modified="2018-04-25" version="1">MATFLYKLGKLAFRRRHFVALIWVALLTLAGVGAASAPTAASSSFSIPGTEAQKAFDLLDQRFPGSSADGATARVVFQAPDGEKITSAANKAEVSKTVADLGSGSKEVAAAADPFVAKTVSKDGTIAYSSVSYKVSSMELTDADRDALQKTVDEARDSGLTVEVGGDALQAMPETGATEIIGVAIAAVVLVITFGSLVAAGLPLLTALIGVGIGVSSITALANALDLGTTTSTLAMMIGLAVGIDYALFIVSRFRAELAEGRDREEAAGRAVGTAGSAVVFAGLTVVIALVGLAVVNIPMLTKMGIAAAGTVAIAVLIALTLIPALLGYAGKRVHGRKARKAQAAEKKPEPKTNMGTRWARFVLRRPVAVLLTAVVGLGVMAVPVSSLELGLPDDGVQPTDTTQRKAYDLLSEGFGPGFNGPLVAVVDVKHSQDPKDAVARVSKDIAATDGVKTVTPPAFNKAGDTATITVVPSFKPSSTQTEGVVHTIRDKGADIKADTRAEVLVTGTTAMNIDVSQKLNDALVPYLALVVGLAFLLLMVVFRSVLVPLKAALGFLLSVVAALGAVVAVYQWGWLGSLFGVEQTGPIMSMMPIFMVGVVFGLAMDYEVFLVTRMREAYVHGERPAQAIVTGFRHGARVVTAAAVIMIAVFAGFIGSSEQMVKMIGFGLAIAVFFDAFLVRMTIVPAVLALLGKRAWWLPKWLDRILPNVDVEGEGLKTVSGDDSAQEDRELVRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JQ25</accession>
    <name>A0A2M9JQ25_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 9">Ribonucleoside-diphosphate reductase</fullName>
            <ecNumber evidence="4 9">1.17.4.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CG723_26225</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">CB01635</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>[thioredoxin]-disulfide + a 2'-deoxyribonucleoside 5'-diphosphate + H2O = [thioredoxin]-dithiol + a ribonucleoside 5'-diphosphate</text>
            <dbReference type="Rhea" id="RHEA:23252"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="ChEBI" id="CHEBI:57930"/>
            <dbReference type="ChEBI" id="CHEBI:73316"/>
            <dbReference type="EC" id="1.17.4.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 9">Genetic information processing; DNA replication.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the ribonucleoside diphosphate reductase large chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.17.4.1" evidence="4 9"/>
    <dbReference type="EMBL" id="NNBL01000011">
        <property type="protein sequence ID" value="PJN08982.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08982">
        <property type="protein sequence ID" value="PJN08982"/>
        <property type="gene ID" value="CG723_26225"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00326"/>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004748">
        <property type="term" value="F:ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013346">
        <property type="entry name" value="NrdE_NrdA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000788">
        <property type="entry name" value="RNR_lg_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013509">
        <property type="entry name" value="RNR_lsu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008926">
        <property type="entry name" value="RNR_R1-su_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039718">
        <property type="entry name" value="Rrm1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11573">
        <property type="entry name" value="PTHR11573"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02867">
        <property type="entry name" value="Ribonuc_red_lgC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00317">
        <property type="entry name" value="Ribonuc_red_lgN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01183">
        <property type="entry name" value="RIBORDTASEM1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48168">
        <property type="entry name" value="SSF48168"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02506">
        <property type="entry name" value="NrdE_NrdA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00089">
        <property type="entry name" value="RIBORED_LARGE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0021">Allosteric enzyme</keyword>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6 9" id="KW-0235">DNA replication</keyword>
    <keyword evidence="7 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RIBORED_LARGE" evidence="11">
        <location>
            <begin position="595"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003410"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS00089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PJN08982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="794" mass="86948" checksum="DC611A9FFB389682" modified="2018-04-25" version="1">MTIAPAEPASELAGNPEQHDAPGTALLRTLTELTADLTDTDPGKVAAAALRGRSAVAASGITAELRSLATEAAAGLISEDPEYSRLAARLLTISIAEEAASQGVTSFSESVAVGHREGLIADRTADFVQLHAERLDALVTASVTEGADDRFGYFGLRTLHSRYLLRHPITRQVVETPQHFMLRVACGLAEDDSVRALDEVTSLYRLMSRLDYLPSSPTLFNSGTRHPQMSSCYLLDSPLDELDSIYDRYHQVARLSKHAGGIGLSYSRIRSRGSLIRGTNGHSNGIVPFLKTLDASVAAVNQGGRRKGAAAVYLETWHSDIEEFLELRDNTGEDARRTHNLNLAHWIPDEFMRRVADDGTWSLFSPSDVPDLVDLWGEEFDTAYRAAEAAGLAQKTMPARELYGRMMRTLAQTGNGWLTFKDAANRTANQTAERGNVVHSSNLCTEILEVTDDGETAVCNLGSVNLGAFVRDGAVDWERLDATVRTAVTFLDRVVDINFYPSEQAGRSNAKWRPVGLGAMGLQDVFFQLKLPFDSPEAKALSTRIAERIMLAAYEASADLAERNGPLPAWEKTRTARGVLHPDHYGVELTWPERWAALRERIAATGMRNSLLLAIAPTATIASIAGVYECIEPQVSNLFKRETLSGEFLQVNSYLVQELKRLGVWDAQTREALRESSGSVQGFGWIPAEVRELYRTAWEIPQRGLIDMAAARTPFLDQAQSLNLFLETPTIGKLSSMYAYAWKSGLKTTYYLRSRPATRIARAASAAPIPVQQAADPEAVACSLENPESCEACQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JQ36</accession>
    <name>A0A2M9JQ36_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CG723_26235</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000011">
        <property type="protein sequence ID" value="PJN08984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08984">
        <property type="protein sequence ID" value="PJN08984"/>
        <property type="gene ID" value="CG723_26235"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PJN08984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="62" mass="7138" checksum="7B445484D9A9683F" modified="2018-04-25" version="1">MEDMNTAMNFLTVLFVFLLLAAPSLYGAAHDRRIDRQIREAQRAARRDAERPSRRAEFTTVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JQ67</accession>
    <name>A0A2M9JQ67_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ser or Arg-related nuclear matrix protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_25480</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000011">
        <property type="protein sequence ID" value="PJN09014.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN09014">
        <property type="protein sequence ID" value="PJN09014"/>
        <property type="gene ID" value="CG723_25480"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.160.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002838">
        <property type="entry name" value="AIM24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036983">
        <property type="entry name" value="AIM24_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016031">
        <property type="entry name" value="Trp_RNA-bd_attenuator-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01987">
        <property type="entry name" value="AIM24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51219">
        <property type="entry name" value="SSF51219"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="213"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN09014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="253" mass="26874" checksum="235473C2133215C1" modified="2018-04-25" version="1">MIFDPATLPADDNVNAYTFCVELKGSSWFLQKGKMIAYYGRIDFNGIGHGRLDRLVRTSFHSPLHASDWVVAEGSGKILLADRAFDVNSYDLENGNLTIRSGNLLAFQPTLALKQSIVPGFLTLIGTGKFVAASSGPVVFMEPPIRVDPQALVGWADCPSPCHHYDHSYLTGVIGGLRAMTGVGGVSGEEHQFEFVGAGTVLLQSTETLMAEQATGAAPQQAGVPGGHGAPGQQPGVPRLPGQLGDLQRRFGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JQB1</accession>
    <name>A0A2M9JQB1_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Histidine kinase</fullName>
            <ecNumber evidence="3">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CG723_24340</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CB01635</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="3"/>
    <dbReference type="EMBL" id="NNBL01000010">
        <property type="protein sequence ID" value="PJN09062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN09062">
        <property type="protein sequence ID" value="PJN09062"/>
        <property type="gene ID" value="CG723_24340"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00672">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00304">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="177"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="9">
        <location>
            <begin position="201"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="8">
        <location>
            <begin position="262"/>
            <end position="474"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PJN09062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="488" mass="51741" checksum="FFE1CCC8B25D359B" modified="2018-04-25" version="1">MNRVVRYFRGLPLRSRLSVLSAVAVAFAVAAVSVTCWFIVHDQLYSKLDDDLRDALPGVPAAQYAQLVANCTTTTAEDNGFGRPQVYYVQIVDSHGTVCVAPNSLGTVEATPEDRAIAKRGDADHVYFRNGVDSDGKPLRVMTRAAVTDGPARAVVQDLALTVAVPLTDTDKTLNNLALVLLVIGGIGVVGAGAAGLWVARTGLRPIDELTNTVEHVARTEDLTVRIPVEGDDEIARLSASFNSMTASLASSRDLQQQLIADAGHELRTPLTSMRTNIELLTRSDETGRAIPPDDRKALMASLKAQMTELAALIGDLQELSRTGLTAGDAPLKVVGLHDTVRTALERAALRGPELTITSELAPWYVRAEPASLERAIVNLLDNAVKFSPPEGTIEVHLMRGRLTVRDHGPGIPADELPYVFDRFWRSQSARALPGSGLGLSIVARTVESCGGTVALGAAEGGGTVATVQLPGAPTPPPEVPEGALDTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JQC5</accession>
    <name>A0A2M9JQC5_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ferric nitrobindin-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_24450</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the nitrobindin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="1">Lacks the conserved His residue that binds heme iron in the nitrobindin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000010">
        <property type="protein sequence ID" value="PJN09079.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN09079">
        <property type="protein sequence ID" value="PJN09079"/>
        <property type="gene ID" value="CG723_24450"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd07828">
        <property type="entry name" value="lipocalin_heme-bd-THAP4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.128.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01297">
        <property type="entry name" value="nitrobindin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012674">
        <property type="entry name" value="Calycin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022939">
        <property type="entry name" value="Nb(III)_bact/plant"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045165">
        <property type="entry name" value="Nitrobindin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014878">
        <property type="entry name" value="THAP4-like_heme-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15854">
        <property type="entry name" value="PTHR15854"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08768">
        <property type="entry name" value="THAP4_heme-bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50814">
        <property type="entry name" value="SSF50814"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="THAP4_heme-bd" evidence="2">
        <location>
            <begin position="12"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="GXWXGXG" evidence="1">
        <location>
            <begin position="20"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01297"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN09079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="190" mass="21258" checksum="9B908753C11FCF7D" modified="2018-04-25" version="1">MIEIPSDLHPDLVPLVFLLGNWAGAGVTDFPGAEKANFGQEVSFTHDGRDFLEYHSHTWILDSEGNKVKPLETESGFWRIDKDRKVDVVMVRDDGVVEIWYGELADQKPQIDLVTDAVARTATAAPHTGGKRLYGYVKSDLMWVGEKQTPEVELRPYMSAQLKKVVSPDDVAEMARNLPDLPDDGIAFFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JQJ5</accession>
    <name>A0A2M9JQJ5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GntR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_24825</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000010">
        <property type="protein sequence ID" value="PJN09140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN09140">
        <property type="protein sequence ID" value="PJN09140"/>
        <property type="gene ID" value="CG723_24825"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07377">
        <property type="entry name" value="WHTH_GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1410.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028978">
        <property type="entry name" value="Chorismate_lyase_/UTRA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011663">
        <property type="entry name" value="UTRA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
        <property type="entry name" value="GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07702">
        <property type="entry name" value="UTRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00035">
        <property type="entry name" value="HTHGNTR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00345">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00866">
        <property type="entry name" value="UTRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64288">
        <property type="entry name" value="SSF64288"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50949">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH gntR-type" evidence="1">
        <location>
            <begin position="34"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN09140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="285" mass="31103" checksum="1A55738AE342CA1C" modified="2018-04-25" version="1">MRMPTPLLESQAPWSNLYGGVGVATWRERMRRGLTKAQEIAADLREQIASGELGGGQALPSESKLMGHYGYSRETVRAGVRVLVDEGLVVTGQGQGKYVREDYPPVVWNWTTLESRKRHETAVEGRTAGDQWASAVADEGKSPRQEISVSIVEPPKHVHAALGLPEGGLAVARKRVRYVDNRPYALADSYFPQELVSGTPLMEPRDVSAPGGVLASVGLVQAKYRDEIAVRMPTLKEAELLALPAATPVAEHTRTGYDADGKPLRCMVTILPGDRHKILYEVDAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JQZ2</accession>
    <name>A0A2M9JQZ2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Molybdopterin dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_23195</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000009">
        <property type="protein sequence ID" value="PJN09262.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN09262">
        <property type="protein sequence ID" value="PJN09262"/>
        <property type="gene ID" value="CG723_23195"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.43.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005107">
        <property type="entry name" value="CO_DH_flav_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036683">
        <property type="entry name" value="CO_DH_flav_C_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016167">
        <property type="entry name" value="FAD-bd_PCMH_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002346">
        <property type="entry name" value="Mopterin_DH_FAD-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03450">
        <property type="entry name" value="CO_deh_flav_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00941">
        <property type="entry name" value="FAD_binding_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01092">
        <property type="entry name" value="CO_deh_flav_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55447">
        <property type="entry name" value="SSF55447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="SSF56176"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="1">
        <location>
            <begin position="1"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN09262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="280" mass="29963" checksum="686933E50953DC8B" modified="2018-04-25" version="1">MKPAPFAYHRARDVDGALRLLADLGDDAKVVAGGQSLVAMMNYRLARPRHLVDIARLRELDRMERDSTGALRIGALTTHHTVERDPQGVLGRDFAVLSRAMEWVGHLPIRTRGTVGGSLAHADATAEWCLLAVVLRARFVVRGPRGERTIPASDFFHGYYTSDLAPDELLVEVVFPRPAPHAALTEFAERRGDFALVAAAVDLDLDVVDGTVRGGRVGLGGVAAAVVRVPEAEEVLAAGGSFADCAATAAAAVDPPEDTAYRKSLVRTLVQRACEEAITA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JR20</accession>
    <name>A0A2M9JR20_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_23570</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000009">
        <property type="protein sequence ID" value="PJN09326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN09326">
        <property type="protein sequence ID" value="PJN09326"/>
        <property type="gene ID" value="CG723_23570"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014728354" evidence="1">
        <location>
            <begin position="40"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="domain" description="AB hydrolase-1" evidence="2">
        <location>
            <begin position="120"/>
            <end position="499"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN09326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="536" mass="57011" checksum="22C61150B9F8AD7F" modified="2018-04-25" version="1">MTFHHAPRRRRPVRRLQATSVGIATGLLVTGLLAAPAQAQSRTDTSAGPEAPIGTAARTVGDARYEPGPCPKTPEPVEALKGARCGSLTVPENRAKSTGRTIKLGVAIVPAKSATPKPDPIVWLAGGPGDDTVGEAKMAIDGGLNRDRDVILMSQRGTYSAEPNLLCPNIDRFNAQAVGLVYDAPSTEGLHVEATKACHDQLAARGIDLSAYNDIESAADYDDLRTALGIKQWNLYAISYGTHLALVYMRLHPDGLRSVGLDGILPPSKGGSALTWSSARQGFDGLFKACADQPACNKRYPNLSATFDKLVRDLEAKPVTTTVKLPGSDKPVKVVLDGGALVNWMTSATHVAPQVPVALDELAHGKPQRIAQQWAGGKLSPQAMGRVAHGLVYGVFCSEWTPYESEEEALQGGQDAFPSFPRSVQAQAPQLTFLRPDCDVWNVPAAPRSIRDVTRGDIPTLALSGSFDSQTGADNGPYVARTLSKAKVVTVPYEPHVVFATSKCAQEITVSFFDTPAAPKTACLKSLEPPKFEIGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JRB6</accession>
    <name>A0A2M9JRB6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GNAT family N-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_23680</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000009">
        <property type="protein sequence ID" value="PJN09430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN09430">
        <property type="protein sequence ID" value="PJN09430"/>
        <property type="gene ID" value="CG723_23680"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN09430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="168" mass="18303" checksum="804A72EFC15E6E25" modified="2018-04-25" version="1">MPTWTIKAEPVLRAGVDEVMREYFTEMGRRVLGRSATDAELRAVLATDPHLTLSPPGGAFLVARNERGDFLGCAGVRLLDSPTATAELKRMYVRPAGRGSGLGRGLLRAVEETAERLGATRIVCETNSQLIEARALYSRHGYQEIEPYEGHGKADHWFGKELPAAAPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-09-29" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JRN2</accession>
    <name>A0A2M9JRN2_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Probable 5-dehydro-4-deoxyglucarate dehydratase</fullName>
            <ecNumber evidence="4">4.2.1.41</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">5-keto-4-deoxy-glucarate dehydratase</fullName>
            <shortName evidence="4">KDGDH</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CG723_22560</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CB01635</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 4">
            <text>5-dehydro-4-deoxy-D-glucarate + H(+) = 2,5-dioxopentanoate + CO2 + H2O</text>
            <dbReference type="Rhea" id="RHEA:24608"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:42819"/>
            <dbReference type="ChEBI" id="CHEBI:58136"/>
            <dbReference type="EC" id="4.2.1.41"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 4">Carbohydrate acid metabolism; D-glucarate degradation; 2,5-dioxopentanoate from D-glucarate: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 4 5">Belongs to the DapA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.41" evidence="4"/>
    <dbReference type="EMBL" id="NNBL01000008">
        <property type="protein sequence ID" value="PJN09529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN09529">
        <property type="protein sequence ID" value="PJN09529"/>
        <property type="gene ID" value="CG723_22560"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00564">
        <property type="reaction ID" value="UER00628"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047448">
        <property type="term" value="F:5-dehydro-4-deoxyglucarate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042838">
        <property type="term" value="P:D-glucarate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00694">
        <property type="entry name" value="KDGDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002220">
        <property type="entry name" value="DapA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017655">
        <property type="entry name" value="Dehydro-deoxyglucarate_dehyd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12128">
        <property type="entry name" value="PTHR12128"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00701">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001365">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01130">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0456">Lyase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR001365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PJN09529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="315" mass="33439" checksum="771753842596AA27" modified="2018-04-25" version="1">MVTRTPLAGTAARLRDGMAQGVLSFPLTSFQADGSLDLDGFRSYLAGQLETNPGALFPACGTGEFSALDEDEYGQVVATAVEVTAGRVPVVAGTGYGYAQALRFARIAEDAGADALLVLPHYLNKAPQDGLVEQLHRIADRTRLPLIAYQRDHVTYDAETVRRIAAIPGVIGLKDGHSDLDRLQRSTLAAPDGFLFFNGAPTAELQARAYATVGIPAYSSAVHAFAPEIANAFFQALSAGDDSRVDTLLADFYVPFVELRDRRPGYAVSLVKAAARLRGRPVGPVRAPLTDPTPSDLADLETLLTTGLNLVGAAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JRR4</accession>
    <name>A0A2M9JRR4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CG723_22840</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000008">
        <property type="protein sequence ID" value="PJN09575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN09575">
        <property type="protein sequence ID" value="PJN09575"/>
        <property type="gene ID" value="CG723_22840"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="SSF81296"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PJN09575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="166" mass="16295" checksum="CB635C69C467F324" modified="2018-04-25" version="1">MPPDLAAVLAGVLLPAGAATAGEPPAVVLHAAPDGGGSACSSRHPCSVGGAEDRVRHLLRAVPSTPDAADLPADTVAQAGLTGRRQRQTTSTLPGVGYAHKATDGGDVLVAGHGFGPGTRVDFDGVPAARITVLSNGVLHAEPPSAADPVRVTVTTHAGSATAVLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JRU9</accession>
    <name>A0A2M9JRU9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Sodium:proton antiporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CG723_22485</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CB01635</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000008">
        <property type="protein sequence ID" value="PJN09517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN09517">
        <property type="protein sequence ID" value="PJN09517"/>
        <property type="gene ID" value="CG723_22485"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007182">
        <property type="entry name" value="MnhB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04039">
        <property type="entry name" value="MnhB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014773744" evidence="8">
        <location>
            <begin position="25"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="72"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="108"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="133"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="164"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="212"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="domain" description="MnhB" evidence="9">
        <location>
            <begin position="108"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF04039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PJN09517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="257" mass="26781" checksum="8F7B4BBC3324D67C" modified="2018-04-25" version="1">MSRKARLWLLTVGSIGVAVLLACAAFDLPGFGGTSHPYGERAVRSALARHTANVISSVNFDQRAFDTLGEESILFAAVLGTVVLLRETRDEHSEPPETVQVDPHVRRYALIALPVTLLIGLYVIAHGQLSPGGGFQGGVIVATALHLLYIAIDYKALERIRPAAAYAIADAAGEAAYVLLGTAGLLAGSAFLANFLPYGTFNTLSSGGTVPLLNAAIGVEVASAIVVLLARFLDQALEIEGGGAGETGSQDEEAKRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JRZ0</accession>
    <name>A0A2M9JRZ0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Acyl-CoA dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CG723_22010</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CB01635</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000008">
        <property type="protein sequence ID" value="PJN09623.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN09623">
        <property type="protein sequence ID" value="PJN09623"/>
        <property type="gene ID" value="CG723_22010"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003995">
        <property type="term" value="F:acyl-CoA dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045008">
        <property type="entry name" value="ACX4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006089">
        <property type="entry name" value="Acyl-CoA_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43188">
        <property type="entry name" value="PTHR43188"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="SSF47203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="SSF56645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00073">
        <property type="entry name" value="ACYL_COA_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0274">FAD</keyword>
    <keyword evidence="3 5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA_dh_N" evidence="9">
        <location>
            <begin position="38"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_M" evidence="8">
        <location>
            <begin position="153"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_1" evidence="7">
        <location>
            <begin position="261"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PJN09623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="418" mass="45822" checksum="F4B5047BC632BC49" modified="2018-04-25" version="1">MPVDVTTVGPGNGHPVVQPPVLGGPENTDYYLLNDLLTDEQQALRQKVRDFMDDEVTPIINPYWERAEFPHELVPKLAQLGIAGFQIPGYGSPGMSNVTAGVVIMELARGDLSMSTFMGVHSALAMMSIALLGSEEQKERFLPQMARLEKIGAFGLTEPAHGTDVVKLETTAHRDGDSYVLNGHKRWIGNATFADYTIIWARGDDGHVGGYVVEKGTPGFEAEVITGKTALRCVQNAQISLTDVRVPAENRLANVNTFRDTEKVLLASRFCVAWESIGAAIAGYETALAYAKQRKQFGVPLAAFQLVQYRLARMLADITDMVCMQYRLSQLMDEGKYSMPRVALAKMHYTERASAILSDARDMLGGNGILLDYHVARHLCDIEAIDTYEGTDTVQALIVGRDITGYSAFVPMAPNGHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JSP0</accession>
    <name>A0A2M9JSP0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">NAD(P)H-quinone dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CG723_19175</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CB01635</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="2">Binds 1 FAD per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000006">
        <property type="protein sequence ID" value="PJN09868.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN09868">
        <property type="protein sequence ID" value="PJN09868"/>
        <property type="gene ID" value="CG723_19175"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045454">
        <property type="term" value="P:cell redox homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016156">
        <property type="entry name" value="FAD/NAD-linked_Rdtase_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001100">
        <property type="entry name" value="Pyr_nuc-diS_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004099">
        <property type="entry name" value="Pyr_nucl-diS_OxRdtase_dimer"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02852">
        <property type="entry name" value="Pyr_redox_dim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000350">
        <property type="entry name" value="Mercury_reductase_MerA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55424">
        <property type="entry name" value="SSF55424"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="2" id="KW-0520">NAD</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyr_redox_2" evidence="4">
        <location>
            <begin position="6"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="domain" description="Pyr_redox_dim" evidence="3">
        <location>
            <begin position="362"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="51"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="126"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="198"/>
            <end position="205"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="285"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="326"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000350-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PJN09868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="482" mass="50539" checksum="E171FE1193A514AA" modified="2018-04-25" version="1">MEYVTRIVIIGGGPGGYEAALVAAQLGAEVTVVDCDGLGGASVLTDCVPSKTLIATAEVMTTFDSSYEELGIIVADDTPHIDSPARVVGVDLGKVNRRVKRLALAQSHDITASVTRAGARVMRGRGRLEGQQAADGSRKVVVRTADGTEETLTADAVLIATGGHPREVPDAQPDGERILNWTQVYDLDELPEELIVVGSGVTGAEFAGAYQALGSRVTLVSSRDRVLPGEDPDAAAVLEDVFRRRGMNVMARSRAQSAKRVGDRVEVTLSDGRVISGTHCLMAVGAIPNSSGMGLEEAGVKLKDSGHIWTDKVSRTTAPGVYAAGDVTGVFALASVAAMQGRIAVYHFLGDAVAPLNLKTVSSNVFTDPEIATVGYTQADVDAGKIDARGVKLPLLRNPRAKMQGIRDGFVKIFCRPGTGIVVGGVVVAPRASELIHPISIAVDNNLTVEQIAKAFTVYPSLSGSIAEVARQLHTRKTADEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JT63</accession>
    <name>A0A2M9JT63_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5 7">50S ribosomal protein L16</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">rplP</name>
        <name evidence="10" type="ORF">CG723_20295</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CB01635</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5 7">Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5 7">Part of the 50S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5 6">Belongs to the universal ribosomal protein uL16 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000006">
        <property type="protein sequence ID" value="PJN10059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030782563.1">
        <property type="nucleotide sequence ID" value="NZ_NNBL01000006.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN10059">
        <property type="protein sequence ID" value="PJN10059"/>
        <property type="gene ID" value="CG723_20295"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01433">
        <property type="entry name" value="Ribosomal_L16_L10e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1170.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01342">
        <property type="entry name" value="Ribosomal_L16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016180">
        <property type="entry name" value="Ribosomal_L10e/L16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036920">
        <property type="entry name" value="Ribosomal_L10e/L16_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000114">
        <property type="entry name" value="Ribosomal_L16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020798">
        <property type="entry name" value="Ribosomal_L16_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12220">
        <property type="entry name" value="PTHR12220"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00252">
        <property type="entry name" value="Ribosomal_L16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00060">
        <property type="entry name" value="RIBOSOMALL16"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54686">
        <property type="entry name" value="SSF54686"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01164">
        <property type="entry name" value="rplP_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00586">
        <property type="entry name" value="RIBOSOMAL_L16_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00701">
        <property type="entry name" value="RIBOSOMAL_L16_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 5 6" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="5 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5 7" id="KW-0699">rRNA-binding</keyword>
    <keyword evidence="5 7" id="KW-0820">tRNA-binding</keyword>
    <feature type="domain" description="Ribosomal_L16" evidence="9">
        <location>
            <begin position="4"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00029546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU004413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU004414"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00252"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PJN10059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="139" mass="15844" checksum="FF2C8B7352035930" modified="2018-04-25" version="1">MLIPRRVKHRKQHHPKRRGQAKGGTTVAFGEYGIQALTPAYVTNRQIEAARIAMTRHIKRGGKVWINIYPDRPLTKKPAETRMGSGKGSPEWWVANVHPGRVMFELSYPNEKIAREALTRAAHKLPMKCRIVRREAGES</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JTN4</accession>
    <name>A0A2M9JTN4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DNA-binding response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CG723_17700</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000005">
        <property type="protein sequence ID" value="PJN10229.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN10229">
        <property type="protein sequence ID" value="PJN10229"/>
        <property type="gene ID" value="CG723_17700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00622">
        <property type="entry name" value="HTH_LUXR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="2"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="domain" description="HTH luxR-type" evidence="3">
        <location>
            <begin position="144"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PJN10229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="214" mass="22544" checksum="45BA101DBF6048BE" modified="2018-04-25" version="1">MRIVIAEDAAVLRELLAQMLTERGHDVCAAVPDADALVAAVAEHRPDVTVVDIRMPPTHTDEGLRAAIDIRREHPGTGVLLFSQYIETKYATRLLAAGSAGVGYLLKDRVANVAEFTDALSRVAAGGTALDAEVVTQLAGASRRGGDLESLTAREREVLALMAEGRTNAAIAQALVVSAGTVEKHVAAIFGKLGLPASEDANRRVLAVLRYLGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-05-25" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JTV5</accession>
    <name>A0A2M9JTV5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NAD-dependent dehydratase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_17630</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000005">
        <property type="protein sequence ID" value="PJN10217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN10217">
        <property type="protein sequence ID" value="PJN10217"/>
        <property type="gene ID" value="CG723_17630"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016831">
        <property type="term" value="F:carboxy-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05257">
        <property type="entry name" value="Arna_like_SDR_e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045869">
        <property type="entry name" value="Arna-like_SDR_e"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016040">
        <property type="entry name" value="NAD(P)-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16363">
        <property type="entry name" value="GDP_Man_Dehyd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD(P)-bd_dom" evidence="1">
        <location>
            <begin position="13"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF16363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN10217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="334" mass="36174" checksum="ACE0767CA389653B" modified="2018-04-25" version="1">MTDHSNWTDRTVLVTGAEGFIGSTLVDMLVERGAKVRAMVHYKPYAEKGYLARYLSDSHSPVEMIAGDVRDAGRVMDAVAGCDTVFHLAALIGIPYSYDSPGAYVQTNVVGTENIAEACRRHSVRRLLHTSTSEVYGTALTAPISETHPLQPQSPYSASKIGADMMALSHWHAFELPVTVVRPFNTYGPRQSARAVIPTILSQLHAGATEIRLGSLTPTRDFTYVTDTAAGFLALADCDRALGESVNLGTGREISVGDLATALIAASGRDAKVVVDPARLRPSGSEVERLLSDNARAREWAGWQPEVSLEDGLKRTSQWVAENIALFATDRYQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JU40</accession>
    <name>A0A2M9JU40_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SnoaL-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_18750</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000005">
        <property type="protein sequence ID" value="PJN10400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN10400">
        <property type="protein sequence ID" value="PJN10400"/>
        <property type="gene ID" value="CG723_18750"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037401">
        <property type="entry name" value="SnoaL-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12680">
        <property type="entry name" value="SnoaL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="SSF54427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SnoaL-like" evidence="1">
        <location>
            <begin position="3"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12680"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN10400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="130" mass="14275" checksum="2B265CC224A79D22" modified="2018-04-25" version="1">MKAFRKAVEANDPDAVEALLAENVVFTSPVAFHPYPGKAMTAAILRGVMRVFEDFRYVREISSADGRDHALVFVTRVGDREVNGCDFIHLDEDGLIDDFTVMVRPLSGAEALSEAMGAQFERIRQEAAGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JUV0</accession>
    <name>A0A2M9JUV0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Acyl-CoA synthetase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CG723_15770</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CB01635</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000004">
        <property type="protein sequence ID" value="PJN10665.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN10665">
        <property type="protein sequence ID" value="PJN10665"/>
        <property type="gene ID" value="CG723_15770"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005324">
        <property type="term" value="F:long-chain fatty acid transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004467">
        <property type="term" value="F:long-chain fatty acid-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030310">
        <property type="entry name" value="FadD17/FadD6-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43107:SF15">
        <property type="entry name" value="PTHR43107:SF15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-binding" evidence="2">
        <location>
            <begin position="26"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding_C" evidence="3">
        <location>
            <begin position="423"/>
            <end position="502"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PJN10665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="555" mass="59985" checksum="C2650C9D8CB85519" modified="2018-04-25" version="1">MGPMRRTVAELVQERWGDHRPGLWCEDQVLSHHEVAAGAAARAALLADLLPRGAEPHIGVLLDNTPEFPLWLSAAALAGAAVAGVNPTRRGPELARDILHTDCRVLVTERSRLPLLDGLRLPGVRILVTDSDAYGELLAPYEGAKPDPARATPETRMLLYFTSGSTGAPKAAICSQGRLAAAGQSLVGQFGVRPDDVHYICMPLFHGNAVIADWAPAVAAGAGVALRRRFSASRFLGDVRAYGATYFTYVGRAVQYILATDERPDDRDNPLRMGFGTEAGAVDAARFAERFGVRLVEGYGSSEGGAAIQRSAGTPAGAIGRATPGDDLAVVDAATRRECPPAEFDADGRLLNGAAAIGELVNRGRTPFEGYWRNEDAHAQRVRDGWYWTGDLFYRDREGFLYFAGRTDDRLRVDSENLAPAMIENILARYEHAAAVAVYGVPDPVAGDQVMATLALRGTDPAEPFDPLGFAEFLLSQADLGTKMAPRFVRIVGRMPVTATNKVHRVGLRREGFRCADPVWWRPPGESGYRSLTDADVTALSQEYAAHGRSELLDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JUY1</accession>
    <name>A0A2M9JUY1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Peptidase M6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_15860</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000004">
        <property type="protein sequence ID" value="PJN10679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN10679">
        <property type="protein sequence ID" value="PJN10679"/>
        <property type="gene ID" value="CG723_15860"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008757">
        <property type="entry name" value="Peptidase_M6-like_domain"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03296">
        <property type="entry name" value="M6dom_TIGR03296"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN10679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="435" mass="47438" checksum="EEFA1D93560CB6A2" modified="2018-04-25" version="1">MSRFPDPEVDLPRPLPPGGVERPRLRSVGAALTALTAMAATSLVAGPAISAPYAGPCSLERTAAHHSEGLDTWNRAYPRPVRTLNAVMVFLSFPDARPTTTPKELTADYFPATSDFYDRASYGKFHLVPHPQRRWLRMPHSSTSYAIERDWDAAHRGAYLRDALHTADRHTDFRKFDVVYFVADPDAPGVDSDATKVVNFDKPMRADGTDIKRIVTVFEQHPPDRNVLAHETGHVFDLPDLYHRPTDGKGDWDTYVGDWDVMGSQFGLAPDFLGWHKWKLGWLDRRQVVCVTSSRRVTLEPLASAPARPGAAPGTNGAPFGSGYGTKLAVVRTGEDSAIALEARDADGNDAATCSEGILVYRVRSETASGHGPVEVLDAHPDTDACFGDSVYPALADAPVRVGESYRVPGENVRIKVEGRTRSGAWTVKVGVGKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JV63</accession>
    <name>A0A2M9JV63_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CG723_16455</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000004">
        <property type="protein sequence ID" value="PJN10773.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN10773">
        <property type="protein sequence ID" value="PJN10773"/>
        <property type="gene ID" value="CG723_16455"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PJN10773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="438" mass="48049" checksum="1F05D80F0E86E57E" modified="2018-04-25" version="1">MGVTGPPGPVMDRDEVDRALARLGAEHEAIETSLFALQDHAGRRLLEGARLTGTTHERWAAADQAITLLWTYFDAYTAALRSAREIRARRRWSSREDLVELTELLRGESVTVAGSGPSTPASLTGPARLSDRFTLADLVERMNDLYASSLDMVVAADAVWSALPARIDLLAAELGRTRQLAHSVGVRPGEHPSGDDLERITHALTRLREDVVSDPLAYWRSAPGSSAPGGGRPDTTAYDREAQALEEVRREIDAVLTVRQDAEVRLGRLRDVLSRADRTLAEARSARGEVLAKIAAFEVPAVSGPPTALQEQLATAAEYRRSAQWHRLSPLLESLETKAEDELLRARESLTEVTQPLAVRAELRGRLDAYKAKVARLGFAEDPLLVERYDAARRMLWSAPCDLRAAEDAVLRYQRAAADVLVPRVPEQGGPADRRGES</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JVH0</accession>
    <name>A0A2M9JVH0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Peptide ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CG723_16420</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CB01635</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000004">
        <property type="protein sequence ID" value="PJN10767.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN10767">
        <property type="protein sequence ID" value="PJN10767"/>
        <property type="gene ID" value="CG723_16420"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003838">
        <property type="entry name" value="ABC3_permease_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02687">
        <property type="entry name" value="FtsX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014825394" evidence="8">
        <location>
            <begin position="32"/>
            <end position="1119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="305"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="348"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="399"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="434"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="475"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="535"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="982"/>
            <end position="1001"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="1036"/>
            <end position="1063"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="1083"/>
            <end position="1103"/>
        </location>
    </feature>
    <feature type="domain" description="FtsX" evidence="9">
        <location>
            <begin position="1013"/>
            <end position="1098"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="134"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="780"/>
            <end position="800"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PJN10767.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="1119" mass="115124" checksum="D50ADF84AB85507A" modified="2018-04-25" version="1">MSGFVLLRVRAHRLLLTAALLAVLLTTSVLAMLSAFSGAIGDAALRNSLRTRDAATTALTVKADVPAEGREAADAAVRSGARDIFGGLPVSVQTLMRSGPYALPRSLQPPAARSGNPDLTQFAALERGEVRITKGRAPKAAQGSTAPHGSRAPVEAALPEAAARQLKLHPGDKLTLKDRLGGPTVSVVFTGVYRPVRPTAPYWKLDDLGGRGIQKISFTTYGPLLTAPSVLAAGRVSAGKSAWLASADFSSVTTADIDALRTGAREGTKALLREKALAGTTGVNTSLPETLDRAERALLVSRSTLLIVALQLVLLATYTLLLVARLLSTDRAGETWMLRARGGSRARVTSLAAIEALLLALPAAVCAPLLAGPLIRLLSSWGALSRIGLRLDVEAGRGVWLVALAVAVGCALAVTVPSLSAAGPGRGRARSLPAPLRAGADVGLLVIAAVAYWQLDRQTSGSGALSSNTSGTLGIDPLLVTAPALALLAGTVLTLRLLPPAARLAERRAAGGRGLPAALAGWQFSRRPLRGAGPVLLLVLAVAMGMLAIGQGASWNRSQEDQADFRAGASLRVLAPGGGLGQAGVYAAAPGVRDAAPAVRATMPLSGGREATLLALDTAHATDHLMLRDDLSEKSPSRLLSSLRTGGHDRSPGVLLPADATGASLTLRLSTPARPHDASPSDVKGSVTATVEDRYGIPYQLFLDDLPADGRAHRLAMSLGGGGSISLERPATPLTLTGLALDIDQPVTTTVKHRLTFEGLRSVNAAGAQQSLKLGTRWRATAQGGSEEDGGTRPGAPVLERRSDGQVSVGFDTGRLNPLTIPFGAPPSMSVRLTAKRPAVKEVTAVATDRFLRSSGAKVGSTVAVPVSGSPLKVRISASVRALPTTGPEAGADTTAGTDAGPKAADGGALLLDLRALNRALTDRHKEPALPGEWWLSTEPGRSAEAAAALRARPDAEPAQVVVRSEIAESLRDDPLGAGPQSALAAAAVAAALLAAVGFAVNTAGSMRERGNEFAILRALGAPRRRLARLVAAEQGILVALALLVGLALGTFLTRAVVPLVVLTGQAIQPMPRVLVELPWGQVLLLLAGVAVTPALITAGLALRRPPDAAITLRRQGSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JVH6</accession>
    <name>A0A2M9JVH6_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5">50S ribosomal protein L21</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4 6" type="primary">rplU</name>
        <name evidence="6" type="ORF">CG723_16870</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CB01635</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4 5">This protein binds to 23S rRNA in the presence of protein L20.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Part of the 50S ribosomal subunit. Contacts protein L20.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4 5">Belongs to the bacterial ribosomal protein bL21 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000004">
        <property type="protein sequence ID" value="PJN10842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055566950.1">
        <property type="nucleotide sequence ID" value="NZ_NNBL01000004.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN10842">
        <property type="protein sequence ID" value="PJN10842"/>
        <property type="gene ID" value="CG723_16870"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01363">
        <property type="entry name" value="Ribosomal_L21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036164">
        <property type="entry name" value="L21-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028909">
        <property type="entry name" value="L21p-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001787">
        <property type="entry name" value="Ribosomal_L21"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018258">
        <property type="entry name" value="Ribosomal_L21_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21349">
        <property type="entry name" value="PTHR21349"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00829">
        <property type="entry name" value="Ribosomal_L21p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141091">
        <property type="entry name" value="SSF141091"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00061">
        <property type="entry name" value="L21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01169">
        <property type="entry name" value="RIBOSOMAL_L21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="4 5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4 5" id="KW-0699">rRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PJN10842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="106" mass="11637" checksum="A782B5E2D614A069" modified="2018-04-25" version="1">MYAIVRSGGRQHKVAVDDIVEVDKISTAKVGDTVELSTLLVVDGDAVTSDPWVLAGIKVQAEVVDHHKGAKIDILRYKNKTGYRRRQGHRQQYTAIKITGIPTAAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JVP4</accession>
    <name>A0A2M9JVP4_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Prim-Pol domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_15870</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000004">
        <property type="protein sequence ID" value="PJN10929.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN10929">
        <property type="protein sequence ID" value="PJN10929"/>
        <property type="gene ID" value="CG723_15870"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015330">
        <property type="entry name" value="DNA_primase/pol_bifunc_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09250">
        <property type="entry name" value="Prim-Pol"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Prim-Pol" evidence="1">
        <location>
            <begin position="17"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF09250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN10929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="196" mass="20928" checksum="590A6B8919E5256B" modified="2018-04-25" version="1">MTRSDRFDIAGATREGAAWLASAGTYPRSTLALWESRPDAPVVLPCGTAFDVVNVPSMFGRRMLDALWEDGPGSGPVAAHRGRMLLFAAPGTAHRLPSLLEWEEWGPAVPPLLCHGSGDAVTVPPPAGGADHAGGPRADSRWVVAPDTLHPWLPGPEVLLWACVRAARASTKPSVRISIFPGPDQDAKVYDVSRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JWC6</accession>
    <name>A0A2M9JWC6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Amphi-Trp domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_09500</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN11174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN11174">
        <property type="protein sequence ID" value="PJN11174"/>
        <property type="gene ID" value="CG723_09500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027598">
        <property type="entry name" value="Amphi-Trp_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20068">
        <property type="entry name" value="Amphi-Trp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04354">
        <property type="entry name" value="amphi-Trp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amphi-Trp" evidence="2">
        <location>
            <begin position="3"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="72"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="99"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN11174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="126" mass="13467" checksum="4BC4E4D8C789E916" modified="2018-04-25" version="1">MKDLKFEQKRSLSRLEAADQLSALAAALREGGDAELELGSATLSLRVPDALRSEVEVEVGNGEIELEIEFKWPTAPTRTAPSRTAAGTEKATARKSVPAKPRRSTTGSAGRSKSGKQSATRTRKTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-09-29" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JWK4</accession>
    <name>A0A2M9JWK4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Glycogen synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CG723_10125</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN11281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN11281">
        <property type="protein sequence ID" value="PJN11281"/>
        <property type="gene ID" value="CG723_10125"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009250">
        <property type="term" value="P:glucan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028098">
        <property type="entry name" value="Glyco_trans_4-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011875">
        <property type="entry name" value="M1P_synthase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13439">
        <property type="entry name" value="Glyco_transf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02149">
        <property type="entry name" value="glgA_Coryne"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_4-like_N" evidence="4">
        <location>
            <begin position="15"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="domain" description="Glycos_transf_1" evidence="3">
        <location>
            <begin position="191"/>
            <end position="362"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PJN11281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="393" mass="42537" checksum="BACE2F0D5E69F74F" modified="2018-04-25" version="1">MRVGLLTREYPPDVYGGAGVHVEFLARELRPLVDLDVHTWGEGGAEGLRRHRAWQALDGANDALRTFSVDLSIAAALEGRELVHSHTWYANLAGHIGKLLHGIPHIVTAHSLEPLRPWKAEQLGGGYALSGWAERTAVEAADAVIAVSGAMRDDILACYPAIDPAKVRVVHNGIDSALYRPDPATDVLARIGIDQNRPYVVFVGRITRQKGVPHLLRAAKELDPSAQLILCAGAPDTPAIGREFRTLVDELRALRDGVHWIPQMLPRTEVVQLLTHARAFVCPSVYEPLGIVNLEAMACGTAVVASAVGGIPEVVADGTTGLLVPYEERDPLAFESGLAQALNRLVGDPDEAARMGAAGRERSEREFGWDTVARRTADVYDEILNTTQPVKMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JX72</accession>
    <name>A0A2M9JX72_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Polysaccharide biosynthesis protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CG723_11255</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CB01635</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN11473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN11473">
        <property type="protein sequence ID" value="PJN11473"/>
        <property type="gene ID" value="CG723_11255"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009103">
        <property type="term" value="P:lipopolysaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003856">
        <property type="entry name" value="LPS_length_determ_N_term"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02706">
        <property type="entry name" value="Wzz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="31"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="250"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="domain" description="Wzz" evidence="7">
        <location>
            <begin position="16"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PJN11473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="508" mass="54415" checksum="D811E26B000758C7" modified="2018-04-25" version="1">MTTSTTSESSAATHLLDLQALVVAVRRRRRLWCSLALLGLLVGAALAVLRPPPPAAQAKVLVAHQADQPNDPGTLIRTDVELLRTTRIADKALQSLNSSERTEDFMRDYRGTGLTNNLLQIEVTGDSDADAVARAKALADAFVADHVRRMQEAAKAEAKALRDQGDRMRGELAQVNKAIGDRTPESDPTASASIESLFARRAELNSRIADFDQRAEEARMGTPQIVAGTQIVDAPRAVRHSLPRTAATNAAIGLVLGLVLGLAVAAVGTVVADRPVLRREIAANLGASVIAELRRAPHRPARRWQRRRTRAARERLTATLARTVRGSAEPVSLLELGCARSTSVIALDLARALAAEGPVVIIDDLPALRRAHRGPKPGGPDVVGVEGAAAVPHEVRRLGVGSVAPGTAWTGLPDLGTRTVLVVRAGHGSAAWLHTVARQLADLLIPVIGVVLIDPDPRDRTDGTLWDGLHTALRGYNERLARENVTGRVRTERPSWAVRVPDSDQEAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JX98</accession>
    <name>A0A2M9JX98_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Phosphotransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_11510</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN11521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN11521">
        <property type="protein sequence ID" value="PJN11521"/>
        <property type="gene ID" value="CG723_11510"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016259">
        <property type="entry name" value="Hygromycin-B_Kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000707">
        <property type="entry name" value="Hygromycin-B_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="APH" evidence="1">
        <location>
            <begin position="44"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN11521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="307" mass="33635" checksum="7B88D391078537E5" modified="2018-04-25" version="1">MLPLVETDGQWDAVVSDEAVMRRGADDLCARLGLTGLPLTRYEGGTQPVYAVGDEHVLKLFPAASAEDGATEARVLAHLEGRLPVPTPEVRSAGAYKNGWLYILMSRLPGADLAVAWPGIPRADQDRIVDEAGACLAALHALDPTPLAGAVGPEDWDTFVRKQRADAVQQQREHGLAEGWLEQIPAFLDSVTLPCGPERVLLHTEFMRQHLVIDPRNRKLTGLLDFEPAMIGDPAYDFVAVGLFVTRADPRLMTRFTEAYGRKFGLRTVMAYTLLHVYSDLPWYLRELPAPPEATLDSLAGAWFAAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JXA6</accession>
    <name>A0A2M9JXA6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Serine/threonine protein phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_11120</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN11452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN11452">
        <property type="protein sequence ID" value="PJN11452"/>
        <property type="gene ID" value="CG723_11120"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07228">
        <property type="entry name" value="SpoIIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00331">
        <property type="entry name" value="PP2C_SIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="SSF81606"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="46"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="70"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="93"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="domain" description="PPM-type phosphatase" evidence="2">
        <location>
            <begin position="149"/>
            <end position="369"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN11452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="373" mass="40317" checksum="25D6516B650F9062" modified="2018-04-25" version="1">MPQNHPKRFARPVESIEPPRNVEVVIGVALVTLLVLVLGALSDSPVWLLGLLVFLPAAASALCTVRQTKFVAAWIALVVVVIVLLRHGDGRSWLDRSLMMLLTLALGAASVYACHRRIRREDEMLRLRSTAAAMQRHILRPLPLLTDDVLVDGAYEPVQEDRLVGGDIYDVVESPWGTRVLIGDVQGKGLPAVGAAFAVIGAFREAAHREPTLTALVDALDASVVRHNSYAARTGDDERFVTALILNVDAHDEVQVINCGHIAPHLLHNATISTPALDSGVPLGLAELATEPVTVDWFAFPAGATLLLTTDGLTETRGADGTFYPVTERLSERVSLSPTDLPHALYDDASAFAGERGQHDDVAILCVRRSPFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JXP2</accession>
    <name>A0A2M9JXP2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Protein phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CG723_11655</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN11547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN11547">
        <property type="protein sequence ID" value="PJN11547"/>
        <property type="gene ID" value="CG723_11655"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="SSF52799"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PJN11547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="124" mass="14024" checksum="D19FEC3DA1D47515" modified="2018-04-25" version="1">MVRGRGLRRPLPPGPSPSYAVHLLGRRPPGVPWESRWLRWPDFWLPSSRDEARKVFADAWERAAGERVEFACGGGRGRTGTALACLAVLDGVPAERAVEFVRRNYDAQAVETPWQRRYVRHFAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JXS6</accession>
    <name>A0A2M9JXS6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alpha/beta hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_12525</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN11685.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN11685">
        <property type="protein sequence ID" value="PJN11685"/>
        <property type="gene ID" value="CG723_12525"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000639">
        <property type="entry name" value="Epox_hydrolase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00111">
        <property type="entry name" value="ABHYDROLASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00412">
        <property type="entry name" value="EPOXHYDRLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="23"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN11685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="268" mass="28895" checksum="E049E3185ABE2422" modified="2018-04-25" version="1">MSRLTSNGVTIHFDDLGPADGVPVVLIHGHPFNRTMWRPQTAALTAAGYRLIAPDLRGYGDSDTVAGTVLFPAFADDIAALLDHLELDRAVVGGVSMGGQITMEFQRSHPQRVRALVLADTSPVAETDEGRVFRNRLADRLLAEGMHDYAGEVIDKMLAAYNVTAMPQVAAHVLEMMRTTEPAGAAAALRGRAERVDYRETLAATSAPTLIVVGADDVYTPPEDARAIQRLTPHATLTVVERAGHLPNMEQPDAVNTALIRFLNSLPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JXW8</accession>
    <name>A0A2M9JXW8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_12140</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN11627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN11627">
        <property type="protein sequence ID" value="PJN11627"/>
        <property type="gene ID" value="CG723_12140"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01300">
        <property type="entry name" value="YtcJ_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013108">
        <property type="entry name" value="Amidohydro_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033932">
        <property type="entry name" value="YtcJ-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07969">
        <property type="entry name" value="Amidohydro_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="SSF51338"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydro_3" evidence="1">
        <location>
            <begin position="46"/>
            <end position="541"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN11627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="551" mass="58040" checksum="84603037B68BE90B" modified="2018-04-25" version="1">MLLDLLVRNARILTLDDDRPSARTLGVLHGRIAGLDEDVEALPARRVLDAGGATLVPGFNDAHCHTAWFGLTLAQLDLSKARSVDEVYAAVADHAEGRPRDAWVIGAGLDHHKLGGVQPHRDALDRAAGGRPVWLKHTSGHACIVNSPVLEKAGALADGFADPTGGVVARDADGRPNGLLEETAQQLVQRQVLPYPMATLADAIGAATRHYLAEGITSFTEAGIGGGWIGHSPVELAAYQLSCDSGRLHTRAQVMAASDVLHPLTAHADDAITLGLDLGMRTGFGDDRLSLGPVKIFLDGSLLGRTAAVTEPFCGCPHDTSATGYFQGDPEAMADTVVAAHRAGWTVAAHAIGDRAVDLALDTFARAQRVHPRPEVRHRIEHAGVVRPDQLARFAELRAVPVPQHNFLYAFGDAMAAALGPQRTPWSYRLRSLLDLGIVVPGSSDRPVAPGAPLPAMQSMVERLTETGAPFGADESVTALAALRAWTVGSAHATGYGDRKGVLRPGHLADFTVLDADPTRISPDRIGAIRILATSVGGTVAHDPLGLTAFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JXY2</accession>
    <name>A0A2M9JXY2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_12815</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN11735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN11735">
        <property type="protein sequence ID" value="PJN11735"/>
        <property type="gene ID" value="CG723_12815"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014896386" evidence="1">
        <location>
            <begin position="26"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN11735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="173" mass="17702" checksum="2C63004DCD3C39EE" modified="2018-04-25" version="1">MDGIMRRRQVTTHIVALVMAVTATAAATGCTRLLDDKGPLPSRSAEPRLSADTAVRELTSALAAEGVTLDRAPQDQIVIECTERLTGRGEPAKAGAALKSGFARARSDHGWKSGPDIGSMSLTLRKGNWTAAATLPPATAASPTTPVTIVVNLVCDGARSKSGTGASPTPAAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JY00</accession>
    <name>A0A2M9JY00_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">FAD-dependent oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_12900</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN11750.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN11750">
        <property type="protein sequence ID" value="PJN11750"/>
        <property type="gene ID" value="CG723_12900"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD_binding_3" evidence="1">
        <location>
            <begin position="2"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN11750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="475" mass="51638" checksum="F75F6E47C649C671" modified="2018-04-25" version="1">MIDVIVVGSGPTGLMLASELRLHGVNVVVLEKLNEPTKESRGQGLHARSVEMMDQRGLLDRFLEVGEKFSVGGLFGGIIKPWPDQLDTAHPFGVKAWQPVTERLLNERALELGAEIRRGCEVAVVSQDEDGVTVELTDGTQLRSRFLVGCDGGRSLVRKQVGVGFPGEPATVETLLGEMGATEDPEAIAAVVEEVRKTQLRFGLIPQGDGIYRISVPAAEVAEDRATAPTLDDFKQQLLAIAGTDFGVHSPRWLSRFGDATRQAERYRVGRVFLVGDAAHIHPPTGGQGLNLGVQDAFNLGWKLAAAVNGWAPEGLLDTYHAERHPVGARVLDNTRAQITLLGTDPGAAALRELLSKLMDFEEVNRYVTGIITAVGVSYDFGEGHELLGRRMRDVELKRGRLYELMHDGRGLLLDRTGSLSVEGWADRVDHVVDVSEQLDVPAVLLRPDGHVAWVGEDQPDLLSHLSKWFGTAAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JYN4</accession>
    <name>A0A2M9JYN4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Protease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_14375</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase A31 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN11993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN11993">
        <property type="protein sequence ID" value="PJN11993"/>
        <property type="gene ID" value="CG723_14375"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008047">
        <property type="term" value="F:enzyme activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023430">
        <property type="entry name" value="Pept_HybD-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000671">
        <property type="entry name" value="Peptidase_A31"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30302">
        <property type="entry name" value="PTHR30302"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01750">
        <property type="entry name" value="HycI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00446">
        <property type="entry name" value="HYDRGNUPTAKE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53163">
        <property type="entry name" value="SSF53163"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00072">
        <property type="entry name" value="hydrog_prot"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN11993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="180" mass="18287" checksum="0CB214208ED27D3D" modified="2018-04-25" version="1">MTGDDKTGARTLVAGVGNIFLGDDGFGVETVRVLATHHLPGHVEVMDIGVRGVHLAYQLLDGYDTLVLVDATARGGDPGTLYRIEVDSPGDIAPQGPVLDGHHMSPDAVLALLETLCSGTGGTPPGRTVVVGCEPASLEEGIGLSAPVAAAVPEAVRLIQAIVCEGEAPAVGTAAHEARK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JYP1</accession>
    <name>A0A2M9JYP1_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Hydrogenase maturation factor HypA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">hypA</name>
        <name evidence="5" type="ORF">CG723_14380</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CB01635</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Involved in the maturation of [NiFe] hydrogenases. Required for nickel insertion into the metal center of the hydrogenase.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the HypA/HybF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN11994.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN11994">
        <property type="protein sequence ID" value="PJN11994"/>
        <property type="gene ID" value="CG723_14380"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016151">
        <property type="term" value="F:nickel cation binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051604">
        <property type="term" value="P:protein maturation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00213">
        <property type="entry name" value="HypA_HybF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000688">
        <property type="entry name" value="HypA/HybF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34535">
        <property type="entry name" value="PTHR34535"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01155">
        <property type="entry name" value="HypA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004761">
        <property type="entry name" value="Hydrgn_mat_HypA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1 4" id="KW-0533">Nickel</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0862">Zinc</keyword>
    <feature type="binding site" evidence="4">
        <location>
            <position position="2"/>
        </location>
        <ligand>
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="74"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="77"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="91"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="94"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PJN11994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="132" mass="14256" checksum="A0FBBBAA9BA95491" modified="2018-04-25" version="1">MHEMSIAMAVVGQVQEAAELNGGVTAVSSVRLQVGELAGVVPDALSFCFELACAETLLEGAELVTESVPGRARCSPCADEWAVGMPPRLCCPRCGEPTPELLAGRELQIVSVRWEEEPTARRRTCEPIFEER</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JYU3</accession>
    <name>A0A2M9JYU3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Chitinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CG723_14730</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN12053.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN12053">
        <property type="protein sequence ID" value="PJN12053"/>
        <property type="gene ID" value="CG723_14730"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00161">
        <property type="entry name" value="RICIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001223">
        <property type="entry name" value="Glyco_hydro18_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035992">
        <property type="entry name" value="Ricin_B-like_lectins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000772">
        <property type="entry name" value="Ricin_B_lectin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00652">
        <property type="entry name" value="Ricin_B_lectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00458">
        <property type="entry name" value="RICIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50370">
        <property type="entry name" value="SSF50370"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51910">
        <property type="entry name" value="GH18_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50231">
        <property type="entry name" value="RICIN_B_LECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014974289" evidence="1">
        <location>
            <begin position="36"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="domain" description="Ricin B-type lectin" evidence="2">
        <location>
            <begin position="34"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="domain" description="GH18" evidence="3">
        <location>
            <begin position="171"/>
            <end position="458"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PJN12053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="458" mass="47409" checksum="AAC3BD101C878A2B" modified="2018-04-25" version="1">MTRPPLARSTVIRGALTTTLLALSAGAFGAASASAATGTITGLAGKCLDVAGASSANGAAVQLYDCNGTAAQQWTVGSDGTIRALGKCLDVTGNSTANGAKLQLWDCTGGSNQKWSVSAAGDIVNQQADKCADVTGNTSTNGTPVQIWSCTGAANQKWTAPTGGGTTPTAPMAVAPYLYNGWGSPPNPTTVMNATGVKWFTLAFVLSNGTCNPQWDGSRPLTGGVDQQTVNTVRANGGDVIPSFGGYSGNKLESSCTSAGALAGAYQKVVNAYGLKAIDIDIEADAYSNPTVQQRTVDALKTIKADNPGIKVYVTIGTGQSGPDTSLINRAANSGLTVESWTIMPFDFGGAGQNMGTLTQRAAEGLKTALKNAYGYSDDQAYRDMGISSMNGITDQNETVTVADFQTILTYAQQHHLARLTFWSVNRDRPCTGGVADSCSGVSQQNWDYTRVFAKYTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K0T0</accession>
    <name>A0A2M9K0T0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">C4-dicarboxylate ABC transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CG723_06960</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CB01635</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000002">
        <property type="protein sequence ID" value="PJN12745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN12745">
        <property type="protein sequence ID" value="PJN12745"/>
        <property type="gene ID" value="CG723_06960"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018385">
        <property type="entry name" value="C4_dicarb_anaerob_car-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018387">
        <property type="entry name" value="YcgA/YfcC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43652:SF6">
        <property type="entry name" value="PTHR43652:SF6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03606">
        <property type="entry name" value="DcuC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="21"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="103"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="145"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="169"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="192"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="226"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="288"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="328"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="361"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="401"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="462"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="488"/>
            <end position="509"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PJN12745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="510" mass="53727" checksum="748CD55A5CF86F51" modified="2018-04-25" version="1">MSAPTDTETPRQPRPKRKFTFPSALTVLAIVTIAVWALAFLVPSGQYDRNDSGAPIQGTYHRVDSGQSIVDRLDDLFLSPVNGLYGILDPKTAVVAPDNTGDLYGSAGVFLFVLAIGAFITVVFATGALDRGIGRLAHRLRDRGALLIAGVMVVFSVLGTVEGFAEETLGFYGLIVPLMLALGYDRMTAVGAIILGAGVGVMCSTVNPFATGVASSAADISLGDGIILRFIMWIALTAVTVAYVIRYAKRVEKDPERSLSGFLPGDREQAQAEAHAVEVPELTGLHKAVLTVTALVFAFMIFSVVPWSSALTGKADAIPYGFELGWSFPQLAALFLVAAVLVGIVARMGEQKLSSTIIQGAADFISPALVILLARGVTVIMNNSKITDTVLHSIEGVVKGTSSGVFAIIVFVVNLPLAFLIPSTSGHATLAMPILAPLADFAGVSRAVVVTAWQAASGWMNLWVPTTAVTIGGVALAKVGYDKYLRFIWPLLAILFVLICGFVAAGAAWT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-09-29" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K0X6</accession>
    <name>A0A2M9K0X6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_07175</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000002">
        <property type="protein sequence ID" value="PJN12785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN12785">
        <property type="protein sequence ID" value="PJN12785"/>
        <property type="gene ID" value="CG723_07175"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041413">
        <property type="entry name" value="MLTR_LBD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17765">
        <property type="entry name" value="MLTR_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="34"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN12785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="287" mass="31082" checksum="E762C62E2282CF22" modified="2018-04-25" version="1">MSDNELGTYLRTRREAVTPAEVGLPTGTRRRTPGLRRSELATLAGISVEYLTRLEQGRDRNPSPPVLGALADALLLPVDERFLLRRLAKESGGDAMFCAGAAAAPPLRTVRPTVRALLDRLESTPAVLVNWIGDVIAHTDAYDRYARPLGILDARQPNIVRYVFTDERARTAYAEWDRVADEQVSHLRHGASIHDPHVAALADELTVTAGAPFADRLAAVPSLPRRTGVDVVAHPEVGSLRLAFETLSLPDADGQRLVVHLPADDATSAALDRLNGRRPGALRAVKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K0Y3</accession>
    <name>A0A2M9K0Y3_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Putative gluconeogenesis factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CG723_07210</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CB01635</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Required for morphogenesis under gluconeogenic growth conditions.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the gluconeogenesis factor family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000002">
        <property type="protein sequence ID" value="PJN12792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN12792">
        <property type="protein sequence ID" value="PJN12792"/>
        <property type="gene ID" value="CG723_07210"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043743">
        <property type="term" value="F:LPPG:FO 2-phospho-L-lactate transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10680">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00973">
        <property type="entry name" value="Gluconeogen_factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002882">
        <property type="entry name" value="CofD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038136">
        <property type="entry name" value="CofD-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010119">
        <property type="entry name" value="Gluconeogen_factor"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30135">
        <property type="entry name" value="PTHR30135"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01933">
        <property type="entry name" value="CofD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF142338">
        <property type="entry name" value="SSF142338"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01826">
        <property type="entry name" value="CofD_related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PJN12792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="345" mass="36680" checksum="5CE8654F3F566E2A" modified="2018-04-25" version="1">MTGRTLRLGSRLRRVTPPTGRRRGAQPKVVALGGGMGLSASLAALRRITGDLTAVVTVADDGGSSGRLRDELGVLPPGDLRKALAALCGDDDWGQTWARVIQHRFQSQGDLHEHAVGNLLIVALWEQLGDHVQALDLVGKLLGAQGRVLPMSAVPLELQALVKGHDPARPDDIDTVRGQATVALTPGEVQSVHLVPHDPPAVPEAVAAVLDADWVVLGPGSWFSSVIPHLLVPDLLDALMATKARRVLSLNLAPQPGETEGFSPQRHLEVLGRHAPKLALDVVLADEAAVPDRESLTDAAKEGFGAAVELAPVARPDGTPRHDPELLAAAYDRIFRMHGRIGPWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K0Z1</accession>
    <name>A0A2M9K0Z1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CG723_07195</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000002">
        <property type="protein sequence ID" value="PJN12789.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN12789">
        <property type="protein sequence ID" value="PJN12789"/>
        <property type="gene ID" value="CG723_07195"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PJN12789.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="315" mass="34691" checksum="5DEC63B7FCBEF6EF" modified="2018-04-25" version="1">MSYGTQHADAGAPALETALRAGPFHVALRAAITARGLPLHRVQHHLTRRGVTVGVTSLSYWQQGARRPQRTESLRAVRALEEILDLPDESLIRLLAKDEEHTARQRPSTRSYRSLVEASGVLEHFLAELGSPPDGGLHTVGHHERVRIGARRELLGLDSQHIVRAHQDGVDRYVAVHHGDPGCSTDHVSVRALENCRTGRVRRHRGTGVVVAELLFDARLRAGDTFLFRYGFEDGTAGPSSEYLRGFGFAGGQYALQVRFTEGVLPVRCHRFTQHSAAAPRGGRQDLTLSASHRAVHVVEPQVRAGILGIGWDWE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K184</accession>
    <name>A0A2M9K184_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Precorrin-2 C(20)-methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">cobI</name>
        <name evidence="9" type="ORF">CG723_07700</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CB01635</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; adenosylcobalamin biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the precorrin methyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000002">
        <property type="protein sequence ID" value="PJN12884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN12884">
        <property type="protein sequence ID" value="PJN12884"/>
        <property type="gene ID" value="CG723_07700"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00148"/>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030788">
        <property type="term" value="F:precorrin-2 C20-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009236">
        <property type="term" value="P:cobalamin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd11645">
        <property type="entry name" value="Precorrin_2_C20_MT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.950.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1010.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000878">
        <property type="entry name" value="4pyrrol_Mease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035996">
        <property type="entry name" value="4pyrrol_Methylase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014777">
        <property type="entry name" value="4pyrrole_Mease_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014776">
        <property type="entry name" value="4pyrrole_Mease_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012382">
        <property type="entry name" value="CobI/CbiL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006364">
        <property type="entry name" value="CobI/CbiL/CobIJ_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00590">
        <property type="entry name" value="TP_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036427">
        <property type="entry name" value="Precrrn-2_mtase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53790">
        <property type="entry name" value="SSF53790"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01467">
        <property type="entry name" value="cobI_cbiL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0169">Cobalamin biosynthesis</keyword>
    <keyword evidence="4 9" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="TP_methylase" evidence="8">
        <location>
            <begin position="8"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR036427"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PJN12884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="254" mass="26071" checksum="D546BAD7E97B75C9" modified="2018-04-25" version="1">MTSNTTHRLTGVGVGPGDPELVTVKGVNALREAAVVVVPVMAAADGTDGGEPGRAEATVLHYVPAVKVVRVVFALNERSDRARREAAWDAAGERVAALLREHGSVAFATIGDPNVYSTFTYLALTVEELVPGTVVATVPGITAMQDLAARSGAVLTEGTEPLTLVPVTAGSAVLKEALAGPGTVVAYKFGRLAGEVAAALRETGRTQDAVWGSALGLPEESIRPAAELETDAALPYLSTLIAPARRDGGRGGKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K1T3</accession>
    <name>A0A2M9K1T3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_00320</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the arylamine N-acetyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000001">
        <property type="protein sequence ID" value="PJN13086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN13086">
        <property type="protein sequence ID" value="PJN13086"/>
        <property type="gene ID" value="CG723_00320"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016407">
        <property type="term" value="F:acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001447">
        <property type="entry name" value="Arylamine_N-AcTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11786">
        <property type="entry name" value="PTHR11786"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00797">
        <property type="entry name" value="Acetyltransf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01543">
        <property type="entry name" value="ANATRNSFRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="SSF54001"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN13086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="287" mass="31860" checksum="39562A63FD4CC7FA" modified="2018-04-25" version="1">MTATNTLRPTIVTMNWNGEDLDLDAYLARIGFTGDVKPDLGTLRALHRAHIAAIPFENLEIMLGRTVDLSLAALQAKLVRQRRGGYCYEQNLLFAAVLERIGFPVKGLGARVRAGATALRAVTHMLTRVTVEDGQEWLCDVGFGAQGLREPIPLRDGIEVRQGPWTFGLVPEGAGVLVLCSLRPGGREEIYAFTLEERYPVDYVVMNHYTSTHPRSAFTHRPVVQRAAVDSQRSLIDMRMSVELPDGTRDEQDVQEGELMDLLAREFGIELSDEDAARLTRMRDAGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K1W3</accession>
    <name>A0A2M9K1W3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_06930</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000002">
        <property type="protein sequence ID" value="PJN13017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN13017">
        <property type="protein sequence ID" value="PJN13017"/>
        <property type="gene ID" value="CG723_06930"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045924">
        <property type="entry name" value="DUF6343"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19870">
        <property type="entry name" value="DUF6343"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="18"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="42"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="70"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="72"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN13017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="98" mass="11088" checksum="C38F0EE8A5751FAA" modified="2018-04-25" version="1">MRTGSEPVTARSALRARLWLSIWGLAWTIFGTVAFILTDRPWWAFACGVLWLIVTVDLFVITRHIRQGPHYQPGPDVPPYDPPDVPPVPPYNPPDDKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K245</accession>
    <name>A0A2M9K245_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Enamine deaminase RidA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CG723_01005</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000001">
        <property type="protein sequence ID" value="PJN13202.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN13202">
        <property type="protein sequence ID" value="PJN13202"/>
        <property type="gene ID" value="CG723_01005"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035959">
        <property type="entry name" value="RutC-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006175">
        <property type="entry name" value="YjgF/YER057c/UK114"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11803">
        <property type="entry name" value="PTHR11803"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01042">
        <property type="entry name" value="Ribonuc_L-PSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55298">
        <property type="entry name" value="SSF55298"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PJN13202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="134" mass="14366" checksum="8488BC54F95F2440" modified="2018-04-25" version="1">MSSIERINPPELSPATGFSHAVTATGGRLVFLAGQTALDADGKITGDTLPEQFERALTNLLTALRHAGGAPDTLARVTVYATDVADYRTHAHELGRVWRELAGRDYPAMAVIGTTRLWDEQALVELDGLAVLPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K2B1</accession>
    <name>A0A2M9K2B1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">UDP-N-acetylglucosamine-lysosomal-acetylglucosaminephosphotransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CG723_01115</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CB01635</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the stealth family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000001">
        <property type="protein sequence ID" value="PJN13220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN13220">
        <property type="protein sequence ID" value="PJN13220"/>
        <property type="gene ID" value="CG723_01115"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016772">
        <property type="term" value="F:transferase activity, transferring phosphorus-containing groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000271">
        <property type="term" value="P:polysaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031358">
        <property type="entry name" value="Stealth_CR1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021520">
        <property type="entry name" value="Stealth_CR2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031357">
        <property type="entry name" value="Stealth_CR3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031356">
        <property type="entry name" value="Stealth_CR4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17101">
        <property type="entry name" value="Stealth_CR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11380">
        <property type="entry name" value="Stealth_CR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17102">
        <property type="entry name" value="Stealth_CR3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17103">
        <property type="entry name" value="Stealth_CR4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0270">Exopolysaccharide synthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Stealth_CR1" evidence="5">
        <location>
            <begin position="297"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="domain" description="Stealth_CR2" evidence="4">
        <location>
            <begin position="338"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="domain" description="Stealth_CR3" evidence="6">
        <location>
            <begin position="488"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="domain" description="Stealth_CR4" evidence="7">
        <location>
            <begin position="564"/>
            <end position="611"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF11380"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF17101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF17102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF17103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PJN13220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="630" mass="69289" checksum="204E5F7444FD669B" modified="2018-04-25" version="1">MPGVRVIAVAQVPRARGTGLQGGDGGCLVGGSDNPESGALVSAYRSAVPVGARQRIVRGVPTPVRKAVKSSLNVADTVRSATVVWAMGGKRRAPRHSAAYSRRVVRVGRRHMRALTVAGATDWAARARNLNIVVSVLDAAGIDYFCVRGTTGGLPAVAIPAKSRPAAEEALQLAFAQAPGYVGPAGGDEARMEPGDEERSWRALRKNKVLRVAWYVCDPTQQLVFGAATGCDLEVWAERDGELRAPRPNRVIDAVQVDAPRKSAPQRLFSPIPPAYHTGDARTLPEFAVQLPEDHQFPIDVVYTWVDDSDPVWRAQRDQVRQGFSGDGLHEQAANDARYTSRDELRYSLRSLHQNAPWVRNIYLVTAGQVPSWLNARHPNLRVLDHREIFSDPSALPTFNSHAIESQLHHITGLSECFLYLNDDVFFGRPVTPAHFFHPNGITKFFTSPALIPGGGIASTDLPVNAAGKNSRWLIAQKFGTAISQKMKHTPHALRLSVLQEIEETFADEHAATQHSRFRSPGDVPIASSLHHYFSYHSARATVGDIQYRYIDLSADLAERRLNTLLANRNMDTFCLNDTVESADPERQKEMLASFLDAYFPVPSPYEVPEHVNILEQSADLDELVKAADR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K2Q5</accession>
    <name>A0A2M9K2Q5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uracil permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CG723_02155</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CB01635</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000001">
        <property type="protein sequence ID" value="PJN13401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN13401">
        <property type="protein sequence ID" value="PJN13401"/>
        <property type="gene ID" value="CG723_02155"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015205">
        <property type="term" value="F:nucleobase transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006043">
        <property type="entry name" value="NCS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017588">
        <property type="entry name" value="UacT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006042">
        <property type="entry name" value="Xan_ur_permease"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00860">
        <property type="entry name" value="Xan_ur_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00801">
        <property type="entry name" value="ncs2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03173">
        <property type="entry name" value="pbuX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01116">
        <property type="entry name" value="XANTH_URACIL_PERMASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="38"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="68"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="126"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="152"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="191"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="216"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="259"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="339"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="368"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="400"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="425"/>
            <end position="448"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PJN13401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="466" mass="47228" checksum="84DDADAE2BC01147" modified="2018-04-25" version="1">MATPAKGPAEGPCSTPPAGLEVHPVDEKLHPSRLVPAALQHIAAMYAGVVTPPLIIGQAVRLDTAGQTRLIAASLLIAGVATLLQTLGVKGLVGNRLPFVNAASSAGIAPMLAIAETNARGDQLPAIYGAVMVAGVFCLAIGPFFGRLLRFFPPLVTGVVITLIGVTLMPVPVAWAQGGDKTAADFGDMKYLGLAAFTLVVILVIQRFGRGFVKQVALLLGLLIGTLAAIPFGMADFGALRSAPVAALPTPFAFGTPEFQPAAILSLCLVMLVLMTESSAGMLAIGEICDRETSGRTITRGLRTDGLATLLGPVFGGFPTSAFAQNVGVVSLTKVRSRYVVAAAGGALLVLGAFPVLGAVVSTVPMPVLGGAGIVLFGSIAVSGIRTLSEAGLDDSSNIILVAVSLGAGIIPLAAPTFYAEFPAWAQTVLGSGISAGALVAVSLNLFFHHLGTRGRATAAAALKSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K2V5</accession>
    <name>A0A2M9K2V5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Glutamate ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CG723_02465</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000001">
        <property type="protein sequence ID" value="PJN13453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN13453">
        <property type="protein sequence ID" value="PJN13453"/>
        <property type="gene ID" value="CG723_02465"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015424">
        <property type="term" value="F:ABC-type amino acid transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030679">
        <property type="entry name" value="ABC_ATPase_HisP-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039085">
        <property type="entry name" value="ABC_ATPase_HisP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="7"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="39"/>
            <end position="46"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PJN13453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="247" mass="27412" checksum="28B2E6247A59175D" modified="2018-04-25" version="1">MAVDPLIELRDVNKYYGELHVLQDINLTVGKGEVVVVIGPSGSGKSTLCRTINRLETIQSGNIRLDGQPLPEEGKALAHLRAEVGMVFQSFNLFAHKTVLQNVSLAQMKVRGRKRDEADKRSQELLDRVGLASQATKYPAQLSGGQQQRVAIARALAMDPKALLFDEPTSALDPEMINEVLEVMQQLARDGMTMVVVTHEMGFARSAANRVVFMADGRIVEDRTPEDFFTNPRSERAKDFLSKILKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K330</accession>
    <name>A0A2M9K330_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Putative pterin-4-alpha-carbinolamine dehydratase</fullName>
            <shortName evidence="4">PHS</shortName>
            <ecNumber evidence="4">4.2.1.96</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">4-alpha-hydroxy-tetrahydropterin dehydratase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">Pterin carbinolamine dehydratase</fullName>
            <shortName evidence="4">PCD</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CG723_02945</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CB01635</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 4">
            <text>(4aS,6R)-4a-hydroxy-L-erythro-5,6,7,8-tetrahydrobiopterin = (6R)-L-erythro-6,7-dihydrobiopterin + H2O</text>
            <dbReference type="Rhea" id="RHEA:11920"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15642"/>
            <dbReference type="ChEBI" id="CHEBI:43120"/>
            <dbReference type="EC" id="4.2.1.96"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the pterin-4-alpha-carbinolamine dehydratase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.96" evidence="4"/>
    <dbReference type="EMBL" id="NNBL01000001">
        <property type="protein sequence ID" value="PJN13533.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN13533">
        <property type="protein sequence ID" value="PJN13533"/>
        <property type="gene ID" value="CG723_02945"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008124">
        <property type="term" value="F:4-alpha-hydroxytetrahydrobiopterin dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006729">
        <property type="term" value="P:tetrahydrobiopterin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00434">
        <property type="entry name" value="Pterin_4_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036428">
        <property type="entry name" value="PCD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001533">
        <property type="entry name" value="Pterin_deHydtase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12599">
        <property type="entry name" value="PTHR12599"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01329">
        <property type="entry name" value="Pterin_4a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55248">
        <property type="entry name" value="SSF55248"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0456">Lyase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PJN13533.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="101" mass="11106" checksum="59729B8261DF3C7B" modified="2018-04-25" version="1">MPLEPLSQKEIEDRLAELPGWSVADDRLTRTYRLANHFAATALVVHIAQIQDELDHHSDLTLGYNTVDLSVNTHSVGGVLTHLDFGLAQRVQEIAPTHGAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K3P5</accession>
    <name>A0A2M9K3P5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Peptidase M24 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_01455</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000001">
        <property type="protein sequence ID" value="PJN13745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN13745">
        <property type="protein sequence ID" value="PJN13745"/>
        <property type="gene ID" value="CG723_01455"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.350.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029149">
        <property type="entry name" value="Creatin/AminoP/Spt16_NTD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036005">
        <property type="entry name" value="Creatinase/aminopeptidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000587">
        <property type="entry name" value="Creatinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000994">
        <property type="entry name" value="Pept_M24"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01321">
        <property type="entry name" value="Creatinase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00557">
        <property type="entry name" value="Peptidase_M24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53092">
        <property type="entry name" value="SSF53092"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55920">
        <property type="entry name" value="SSF55920"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Creatinase_N" evidence="2">
        <location>
            <begin position="16"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M24" evidence="1">
        <location>
            <begin position="158"/>
            <end position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN13745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="374" mass="39724" checksum="B005D6B0DC47B344" modified="2018-04-25" version="1">MTATPAPFTADDYKARMERAARSAADAGLAGVLVAPGPDMVWLTGYSPTADTERLTMLVLAPGRDPVLVVPTLEAPDAAKAVGADALTLRDWTDGKDPYAVTAPLLDGSGRFGISDNAWAMHLIGLQKTLPDTSYASLTEALPMMRAVKDAAELERLTAAGEAADATYEEIKKVPFAGRRETDVAGDLADLLRQFGHSQVDFTVVGSGPNGANPHHEAGERVIENGDMVVLDFGGLKHGYGSDTSRTVHVGEPTAEEQRVHDVVREAQAAGCAAVEPGAACQDVDRAARAVITEFGYGQFFIHRTGHGIGVTTHEPPYMIEGEELPLVPGMCFSVEPGIYLPGRFGVRIEDIVTVTEDGVRRLNSTSRDMAIVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K3Z3</accession>
    <name>A0A2M9K3Z3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Saccharopine dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_03570</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000001">
        <property type="protein sequence ID" value="PJN13800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN13800">
        <property type="protein sequence ID" value="PJN13800"/>
        <property type="gene ID" value="CG723_03570"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005097">
        <property type="entry name" value="Sacchrp_dh_NADP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03435">
        <property type="entry name" value="Sacchrp_dh_NADP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sacchrp_dh_NADP" evidence="1">
        <location>
            <begin position="17"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN13800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="400" mass="43299" checksum="F55687E8286069CF" modified="2018-04-25" version="1">MRDRPGRADRTGREYDIVLFGATGFAGALTAEYLAAHAPEGLRWAVAGRDTGKLERLRERLTAIDPACAVLPLVRADVADPASLRALAARTRVVATTVGPYVTYGQDLVAACAEEGTDYTDLCGEPEFVDVTYVRHDARARETGARLVHACGFDSIPHDLGVLFTVGQLPEDVPLRIDGFVRSNATFSGGTFASALTQFSRGRQMLAAQQDRRRHQPRLVGRRAYAPTGAPRYAKEVDAWALPLPTIDPQIVQRSARVLERYGPDFRYRHYAAVRHLPVAFGGVAATGALFTAAQLPPARRWLSDRLKPGDGPDEARRAASWFSVRFVGEGGGRRVYTEVSGGDPGYDETAKMLGESAMCLALDDLPETSGQVTTAVAMGDALTARLQDAGIRFRVAATR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JET7</accession>
    <name>A0A2M9JET7_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HTH gntR-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_44915</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000049">
        <property type="protein sequence ID" value="PJN05410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN05410">
        <property type="protein sequence ID" value="PJN05410"/>
        <property type="gene ID" value="CG723_44915"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
        <property type="entry name" value="GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH gntR-type" evidence="1">
        <location>
            <begin position="10"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN05410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="68" mass="6950" checksum="E16D24CDB541D41B" modified="2018-04-25" version="1">MARGSDASSARIAVDLALAIQQGKIPPGQKLPTRPQLAQTYGAALPTVGAAVTRLSNAQLIEQEGPSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JEV2</accession>
    <name>A0A2M9JEV2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GNAT family N-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_45365</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000053">
        <property type="protein sequence ID" value="PJN05342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN05342">
        <property type="protein sequence ID" value="PJN05342"/>
        <property type="gene ID" value="CG723_45365"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13302">
        <property type="entry name" value="Acetyltransf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="4"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN05342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="175" mass="19117" checksum="30246E2E4100200D" modified="2018-04-25" version="1">MTDIGLVPWTDDDFDLLLKNNAPEMTAHLGGPETLDQLMDRHRRYLALSTLDGHGRMFRITAGPDAPAAGSIGYWATPWQGERVWETGWGVLPGYQGRGIAAAAARLVAAHAAADRARLRHLHAFPPVDHPASNGVCRSAGFTLRGPCDLEYPKGCAIRCHDWHLDLRTLSRASS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JEZ1</accession>
    <name>A0A2M9JEZ1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_44615</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000048">
        <property type="protein sequence ID" value="PJN05470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN05470">
        <property type="protein sequence ID" value="PJN05470"/>
        <property type="gene ID" value="CG723_44615"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016566">
        <property type="entry name" value="UCP010219"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11361">
        <property type="entry name" value="DUF3159"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF010219">
        <property type="entry name" value="UCP010219"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="29"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="53"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="80"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="104"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="152"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="183"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN05470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="225" mass="23837" checksum="E8AFDFA03E97E089" modified="2018-04-25" version="1">MQTTSPQEAATDMQAADQRKKKSALEQAGGTKGVIYSALPAVVFVVANNARGLKVGILAALLVALGIAVQRLIRKESIQPALGGMFGVAIAAGISWYTGSAKDFFLIGIWLSLAGAVAFILSVVLRWPLAGLIWNSTTGKGTVWRADKRSRFYYDIATLVLAAIFGARFAVQQYLYQADEVGSLGFAKIAMGYPLLAVGFLAVAWAARASDKRLKGVGLLPAKSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JFN1</accession>
    <name>A0A2M9JFN1_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HTH_21 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_43725</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000044">
        <property type="protein sequence ID" value="PJN05613.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN05613">
        <property type="protein sequence ID" value="PJN05613"/>
        <property type="gene ID" value="CG723_43725"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025948">
        <property type="entry name" value="HTH-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13276">
        <property type="entry name" value="HTH_21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH_21" evidence="1">
        <location>
            <begin position="38"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN05613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="167" mass="18863" checksum="6EDE14DAB571D9FC" modified="2018-04-25" version="1">MVGGGGVCLAGSEDASDVVTWRRVSAAVPGRRRPVRTYISRVHAENYGVYGVRKVWRRLHRERIAVARCTVARLMRELGLEGARRGKRIRTTVRDDGHERATELLRRDFTARCNSPVLQRLVELAQYTSFAFTAHLLEAVSTPRSAPSVMPWTMRSWSPRSASTKRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JFV6</accession>
    <name>A0A2M9JFV6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Nucleotidyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CG723_42845</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000041">
        <property type="protein sequence ID" value="PJN05774.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN05774">
        <property type="protein sequence ID" value="PJN05774"/>
        <property type="gene ID" value="CG723_42845"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018775">
        <property type="entry name" value="RlaP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34817">
        <property type="entry name" value="PTHR34817"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10127">
        <property type="entry name" value="RlaP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PJN05774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="248" mass="27769" checksum="A82BF1DD8D41680A" modified="2018-04-25" version="1">MAEALDLVRDHTIYSCVMGSRAFGLATDGSDTDRRGVFVAPTPMFWRFEKPPTHVDGPADEQFSWELERFCELALRANPNILECLHSPLVEHVTDTGRELLDLREAFLSQQVHATFTGYALGQRKKLDADVRQYGAPRWKHAMHLLRLLASCRDLLRTGRLTLDVGEDRAALLAVKRGEVSWDGVVARMARLGAEAEEAAVRTPLPAEPDRARVADFLIDVRRASALQPEPYDEIVQGVVDGRGVRQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JGC7</accession>
    <name>A0A2M9JGC7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Aminotransferase DegT</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CG723_42120</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CB01635</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the DegT/DnrJ/EryC1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000038">
        <property type="protein sequence ID" value="PJN05928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN05928">
        <property type="protein sequence ID" value="PJN05928"/>
        <property type="gene ID" value="CG723_42120"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044249">
        <property type="term" value="P:cellular biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="CDD" id="cd00616">
        <property type="entry name" value="AHBA_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000653">
        <property type="entry name" value="DegT/StrS_aminotransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30244">
        <property type="entry name" value="PTHR30244"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01041">
        <property type="entry name" value="DegT_DnrJ_EryC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000390">
        <property type="entry name" value="PLP_StrS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="2 3" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="active site" description="Proton acceptor" evidence="1">
        <location>
            <position position="194"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="2">
        <location>
            <position position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR000390-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000390-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU004508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PJN05928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="420" mass="46269" checksum="09BB6B8A1738F5D7" modified="2018-04-25" version="1">MSAVALGGGTYRVPFARRGSVLGEADLAALAELVRAEGTLTAGVWRDRFEERFRERIGARHALTVTSGTVALELATRLLDLAPGDEVIATPQTFQATIQPLLNHDVRVRFCDVDPDTLNMDPDVLETLITDRTRAVFLVHYGGNPADMDRIMAIARRHGAIVVEDSAHGIGALYKGRHPGALADIGCFSFHSTKNITTLGEGGMITLARDEWAERVLRIRDNEVDGVYTARTDLAGEPPALLPWMKFADAVYGRTAVGIRGAGTNATMSEAAAAVGVVQLDSLDRFVERRRWIAGRLDEALSAFPGVRLHRATADSRHAYHLYTFFLTDGREVREHFVRAVDLLGVEVQLRYFPLHLSPEWRLRGHGAGECPNAERVWFEEHMNLPCHPGLTDDQVDHLVTSVTQALHEAYEKASLARIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-06-02" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JGP2</accession>
    <name>A0A2M9JGP2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_41325</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000036">
        <property type="protein sequence ID" value="PJN06045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN06045">
        <property type="protein sequence ID" value="PJN06045"/>
        <property type="gene ID" value="CG723_41325"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="196"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="349"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="352"/>
            <end position="368"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN06045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="651" mass="67811" checksum="438281F395E0BEAA" modified="2018-04-25" version="1">MIYEVTADGVLKSYQDRSDSGGSVLTPVKTYDANWTARHNRVWSNGDLIFSIHGGGKLEVFQQSSPLTGDGELKLDAFPLTVSNPAVVAFTSADDVWAVGSTTYTLTDGVIRAWAYTASPHPSFPAQGTVVATTDTTQRQGWGVGPGTVRTAMSDGTVQAYAGTPNLTVTNSEYGVGLFGEVLADTATCLADAGDEKPTLGAAGDDPDAPAAVAEEPGEPPAPGAPEVLKGKFTLGNGTPAAGLTVKVEATDAVPEDGAEVDLPSLGTAVTAADGSWSLTLPKTLPAEVQQAATENGGLVNAMATVTGQTSTGVPMGGITHLTAAPATATASARSLAVADDETAEPAELLPLGTSSDSSEVSSLSEAQDPAVNVKMAAGYAKSWAAKREAEPTDTLGDSPLPKWQNATGNLPTGYNPYIVNGQDTKGLVVRPMDGGCDRTKSKVIDKKIYYTTVGEGHAYWDAKASVDYDSKLSSTVDVAAKTGGNWTITGSVSLGSSMSVTTGYTAKGPYFGKQWKVPIKYTKYKETWKCGGNNSFTRYVIKPGKYTIPAGGATGKYGKDVSSKDGSGYWDAPKSHRAYVTRGSYFQLSKNRSIKFSGAVSAYGVSLGGSTGYDRDHKQRITAGNKSSYKHYIWGKNGSPSGKPGVFYSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JGZ9</accession>
    <name>A0A2M9JGZ9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_40885</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000035">
        <property type="protein sequence ID" value="PJN06145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN06145">
        <property type="protein sequence ID" value="PJN06145"/>
        <property type="gene ID" value="CG723_40885"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029476">
        <property type="entry name" value="DNase_NucA_NucB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14040">
        <property type="entry name" value="DNase_NucA_NucB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="17"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="96"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="17"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN06145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="151" mass="16606" checksum="F53386599EB5FECC" modified="2018-04-25" version="1">MPFSTKTDAPERLAAQHIKDAYDKPGTTKPDNTSKDIPGRTADRPLTRLYADTSRRNANRRAAVATCKKYWGDNYADGGNECDEFPFSTTYEGAAQASAKYDPQGKAPKNNYSARPIPKTDNGAGGTLMSLFYKYNRIIDGPNDGFLVEVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JH91</accession>
    <name>A0A2M9JH91_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">TetR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_40230</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000033">
        <property type="protein sequence ID" value="PJN06248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN06248">
        <property type="protein sequence ID" value="PJN06248"/>
        <property type="gene ID" value="CG723_40230"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="49"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="72"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN06248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="234" mass="25237" checksum="92F859127B9DAF49" modified="2018-04-25" version="1">MTRDSLRKGVEVVVQPAAARVPPREYWACFRLLSSLSTSVPTSMYSGFMSTSERLIESTRELLWERGYVGTSPKAIQQRADAGQGSMYHHFGGKQDLALAAIERTAQEMRATAAKSFDGAGSAYARIEAYLRRERDVLRGCPIGRLTMDPDVIASDALRAPVDETIDWLREQLAGIVEEGKEQGEFAPSLDAEEIAATIVATVQGGYVLARASGSPAAFDAGVRGLLSLLVPAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JHE8</accession>
    <name>A0A2M9JHE8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Helix-turn-helix transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CG723_39860</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000032">
        <property type="protein sequence ID" value="PJN06301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN06301">
        <property type="protein sequence ID" value="PJN06301"/>
        <property type="gene ID" value="CG723_39860"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00622">
        <property type="entry name" value="HTH_LUXR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH luxR-type" evidence="3">
        <location>
            <begin position="178"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="163"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PJN06301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="245" mass="25387" checksum="91A8848C796AD84D" modified="2018-04-25" version="1">MLGVHECVRGRVMPEAGIDFVPSAKLRVLPGGAAASAPGGVRLFLVGGDALARAGVRSLLDSHDDITFVGDDEPGPRAVASLRAHRPDVLVLHGLREPREVAAVLEDVDPALPVLTVGGCEPDARTAPALHGHLPATTTARQLAAAVSLAAAGYALARGPLPAAAGAPARPRGTTSVSDVPPDALTGREGQVLDLVSRGLSNTEIAQSLTLSEHTVKTHVQNLLHKLHLRNRVHVAIYAFEAGLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JHN3</accession>
    <name>A0A2M9JHN3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CG723_39720</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CB01635</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GPN-loop GTPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000031">
        <property type="protein sequence ID" value="PJN06388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN06388">
        <property type="protein sequence ID" value="PJN06388"/>
        <property type="gene ID" value="CG723_39720"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004130">
        <property type="entry name" value="Gpn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03029">
        <property type="entry name" value="ATP_bind_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PJN06388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="204" mass="22362" checksum="7A068AF664F00F0C" modified="2018-04-25" version="1">MASEHSEETNADHADNSALALKILVAGGFGVGKTTLVGAVSEIRPLRTEELLSELGQNVDDTGAVERKTTTTVAMDFGRITIRSGLSLYLFGTPGQDRFWFLWDELSQGALGAVVLADTRRLEDSFPAVDYFEHRRIPFVVAVNCFTNARAYGAREVSRALDLDRGTPVVLCDARDRDSGKEVLIRLVEYAGRMHTARLLDSVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JHV8</accession>
    <name>A0A2M9JHV8_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Chaperone protein DnaK</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">HSP70</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Heat shock 70 kDa protein</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Heat shock protein 70</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6 9" type="primary">dnaK</name>
        <name evidence="9" type="ORF">CG723_39325</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CB01635</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Acts as a chaperone.</text>
    </comment>
    <comment type="induction">
        <text evidence="6">By stress conditions e.g. heat shock.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6 7">Belongs to the heat shock protein 70 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000030">
        <property type="protein sequence ID" value="PJN06450.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN06450">
        <property type="protein sequence ID" value="PJN06450"/>
        <property type="gene ID" value="CG723_39325"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.34.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00332">
        <property type="entry name" value="DnaK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012725">
        <property type="entry name" value="Chaperone_DnaK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018181">
        <property type="entry name" value="Heat_shock_70_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029048">
        <property type="entry name" value="HSP70_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029047">
        <property type="entry name" value="HSP70_peptide-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013126">
        <property type="entry name" value="Hsp_70_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19375">
        <property type="entry name" value="PTHR19375"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00012">
        <property type="entry name" value="HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100920">
        <property type="entry name" value="SSF100920"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02350">
        <property type="entry name" value="prok_dnaK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00297">
        <property type="entry name" value="HSP70_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00329">
        <property type="entry name" value="HSP70_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at transcript level"/>
    <keyword evidence="4 6 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0143">Chaperone</keyword>
    <keyword evidence="3 6 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2 6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6" id="KW-0346">Stress response</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="587"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="modified residue" description="Phosphothreonine; by autocatalysis" evidence="6">
        <location>
            <position position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PJN06450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="636" mass="67985" checksum="18B2F5FDEE1EBC62" modified="2018-04-25" version="1">MAKAVGIDLGTTNSVIAAWEGGEATVLPNAEGSRTTPSVVAFTDTGERLVGQLARRQTILNPKGTIYSAKRFIGRRYDEISDEAKAVGFDVVADDHGNARFEVRGKLYAPEEISALVLRKLADDAAKQLGEKVTEAVITVPAYFNDAQRTATKDAGRIAGLEVLRIINEPTAAALAYGLDKKGHETVLVFDLGGGTFDVSLLDVGDGVVEVRSTAGDSHLGGDDFDRRLVDYLADNFQRDNGIDLRSDPQALQRLFEAAEKAKTELSSVTQTQVSLPFITADAAGPKHLTETVMRSTFDQITSDLVERTMEPVKQAMADAKISENDIDEVILVGGSTRIPAVQNLVRRLTGGKDPNMSVNPDEVVAMGAAIQAGVLKGDVKDVLLLDVIPLSLGVETRGGVMTKIIERNTTIPVRRTETFSTAEDNQGAVDIVVLQGERELANDNRVLGRFQLKDIRPAPRGEPQVEVTFDIDANGILNVTARDKDTGAEQGITISEGSNLDQSEVERMVQEAEAHRGEDQALRAAVDARNELDAVAYQVERRLNELGDAAPAHEKARAEMLVTDAREAVKGEAPLDKVRSLTSELQQIHASLASHQAGAGPSSEERATADAGADGASGSSAGSDDDVVDAEFDKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JIC6</accession>
    <name>A0A2M9JIC6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_38555</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000028">
        <property type="protein sequence ID" value="PJN06620.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN06620">
        <property type="protein sequence ID" value="PJN06620"/>
        <property type="gene ID" value="CG723_38555"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="43"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN06620.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="131" mass="14037" checksum="FE42D75BA4A6F72A" modified="2018-04-25" version="1">MSSHVSNQARVIPLRPALRPVPAEPAGVPPKEPLWRDIVGDVLRRERLAQERTLKDVADAARISLPYLSEIERGLKEASSEVLAAAAHALGLGLADVLALGRSELLRLATPPAGHTVRRAAPRQGEVRLAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JID9</accession>
    <name>A0A2M9JID9_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Alpha-1,4-glucan:maltose-1-phosphate maltosyltransferase</fullName>
            <shortName evidence="3">GMPMT</shortName>
            <ecNumber evidence="3">2.4.99.16</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">(1-&gt;4)-alpha-D-glucan:maltose-1-phosphate alpha-D-maltosyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">glgE</name>
        <name evidence="6" type="ORF">CG723_38990</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CB01635</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Maltosyltransferase that uses maltose 1-phosphate (M1P) as the sugar donor to elongate linear or branched alpha-(1-&gt;4)-glucans. Is involved in a branched alpha-glucan biosynthetic pathway from trehalose, together with TreS, Mak and GlgB.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 3">
            <text>[(1-&gt;4)-alpha-D-glucosyl](n) + alpha-maltose 1-phosphate = [(1-&gt;4)-alpha-D-glucosyl](n+2) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:42692"/>
            <dbReference type="Rhea" id="RHEA-COMP:9584"/>
            <dbReference type="Rhea" id="RHEA-COMP:10183"/>
            <dbReference type="ChEBI" id="CHEBI:15444"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:63576"/>
            <dbReference type="EC" id="2.4.99.16"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="2 3">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyl hydrolase 13 family. GlgE subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.99.16" evidence="3"/>
    <dbReference type="EMBL" id="NNBL01000029">
        <property type="protein sequence ID" value="PJN06527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN06527">
        <property type="protein sequence ID" value="PJN06527"/>
        <property type="gene ID" value="CG723_38990"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016758">
        <property type="term" value="F:hexosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030979">
        <property type="term" value="P:alpha-glucan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02124">
        <property type="entry name" value="GlgE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026585">
        <property type="entry name" value="GlgE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021828">
        <property type="entry name" value="GlgE_dom_N/S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006047">
        <property type="entry name" value="Glyco_hydro_13_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10357:SF203">
        <property type="entry name" value="PTHR10357:SF203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11896">
        <property type="entry name" value="DUF3416"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00642">
        <property type="entry name" value="Aamy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aamy" evidence="5">
        <location>
            <begin position="236"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Maltose 1-phosphate binding" evidence="3">
        <location>
            <begin position="563"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="10"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="3">
        <location>
            <position position="423"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="3">
        <location>
            <position position="452"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="293"/>
        </location>
        <ligand>
            <name>alpha-maltose 1-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:63576"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="353"/>
        </location>
        <ligand>
            <name>alpha-maltose 1-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:63576"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="388"/>
        </location>
        <ligand>
            <name>alpha-maltose 1-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:63576"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="424"/>
        </location>
        <ligand>
            <name>alpha-maltose 1-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:63576"/>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="3">
        <location>
            <position position="509"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PJN06527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="708" mass="78727" checksum="BC7220D27C1B3205" modified="2018-04-25" version="1">MPAQSPSPKPHTDPAKQSARSAKSQKPPGRRRPPAASATTLGRIPVLDVQPLVDHGRRPAKAVAGESFQVSATVFREGHDAVAANVVLRSPRGRTGPWTPMRELAPGTDRWGAQVTPTSEGRWTYFVEAWGDPVTTWRRHAQIKVPAGIDTELVLEEGALLYERAAEGVPQRKGQRETVLRAAAALRDTELPAAARLAAALTPQVDEVLARHPLRELVTSSDPLPLRVERERALYGAWYEFFPRSEGAIVREGEPPVSGTFHTAAKRLPAIAAMGFDVLYLPPIHPIGTTYRKGPDNSLSPGPHDVGVPWAIGSPEGGHDAIHPDLGTLDDFDAFVSRAADLGLEIALDFALQCSPDHPWVDKYPEWFHHRPDGTIAYAENPPKKYQDIYPIAFDKDMPGLIAETTRVLRFWMDHGVRIFRVDNPHTKPVVFWERVIKGINRTDPDVIFLAEAFTRPAMMRTLAQAGFQQSYTYFTWRNTKQELTEYATELAKDTAAYMRPNFFVNTPDILHAYLQNGGRPAFEVRAVLAATLSPTWGVYSGYELCENAPLRPGSEEYLHSEKYELRPRDWESAEHEGRSIAPLITRLNDIRRRSPALRRLRDVHFHHTDKDTVIAYSKSVAGAHGSNTVLVVANLDPHHTQEATVSLDMPQLGLGWHESAPMRDELTGETYHWGRANYVRLEPGRTPAHILTVLRPSSPLIGGSPTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JIF1</accession>
    <name>A0A2M9JIF1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Peptidase S8</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CG723_37905</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000027">
        <property type="protein sequence ID" value="PJN06659.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN06659">
        <property type="protein sequence ID" value="PJN06659"/>
        <property type="gene ID" value="CG723_37905"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013784">
        <property type="entry name" value="Carb-bd-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008969">
        <property type="entry name" value="CarboxyPept-like_regulatory"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000209">
        <property type="entry name" value="Peptidase_S8/S53_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023828">
        <property type="entry name" value="Peptidase_S8_Ser-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015500">
        <property type="entry name" value="Peptidase_S8_subtilisin-rel"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00082">
        <property type="entry name" value="Peptidase_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00723">
        <property type="entry name" value="SUBTILISIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49452">
        <property type="entry name" value="SSF49452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49464">
        <property type="entry name" value="SSF49464"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="SSF52743"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00138">
        <property type="entry name" value="SUBTILASE_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0720">Serine protease</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014799559" evidence="4">
        <location>
            <begin position="34"/>
            <end position="844"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_S8" evidence="5">
        <location>
            <begin position="190"/>
            <end position="451"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PJN06659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="844" mass="86935" checksum="29BED7F2A6272D93" modified="2018-04-25" version="1">MHLPRSPRRRSAAWAAAAITAAAVLIGPAPAFAQSDTTTRSTAEVDPSVLDTVGKGKDSTFFVVLKKQADLSAAKGGRTHAAKAKSAFAALRAKAKSSQQPLQSFLDKEKVGYQSFWIANALKVTGDERLVEDLAKRADVASIVKEHHYALDATESRVSDAAGDSDPVTPEWGVKDIKADQVWDQYDDRGEGIVIANVDSGVQYDHPALKANYRGNNGDGSFTHDYNWYDPTGQCPTSAPCDNNGHGTHTMGTMVGAGGVGVAPGAKWIAAKGCESSSCSDSSLLAAGQWILAPTDHTGQNPRPDLAPDIVNNSWGGGDTTFYQDIVEAWNAAGIFEAFASGNDGDGVTCSTGHAPGSQAPAYGVGAYDVDGKIADFSGFGPSRLDGSMKPNISAPGVNVRSTWPGNTYKAISGTSMATPHVAGAVALLWSSAPSLIGNIDATRALLNEGARNVGDTHCGGTADANNVWGEGKLDIFASVDKAPHTAAVVTGKVTDKATGSALSGVTVKASGSDSNRTVTTSADGSYRLTLPAGTYDFALGGYGYADGARSGVAVTTGEQVTEDFTLTAVASHAVSGTVLDVTGKPLAKATVQVAGTPVAAVTTDSAGRFNLPKVAEGSYTLTATPAAPVLCNGTYNGKLTVDGDETLTARVPARSDSTGNSCTPAAYSWIAGSGKVALSGDEDARTIALPFPVKLYGVSYSSASVTTNGLINFMEPRLGDYENVALPSADKPNGTVAAFWDDLTLDKKSSVQTSTTGTAGSRKFAVVWNNAAFAEGSSGRVSFEAVFDEATGAVSLQYQSVPGSGASATVGIENQSGTDALQYSFDEPVLKDHSAIRIAQGTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JIF9</accession>
    <name>A0A2M9JIF9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Acyl-CoA dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CG723_38025</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CB01635</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000027">
        <property type="protein sequence ID" value="PJN06675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN06675">
        <property type="protein sequence ID" value="PJN06675"/>
        <property type="gene ID" value="CG723_38025"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016627">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="SSF47203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="SSF56645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0274">FAD</keyword>
    <keyword evidence="3 5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA_dh_N" evidence="8">
        <location>
            <begin position="9"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_M" evidence="7">
        <location>
            <begin position="134"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_1" evidence="6">
        <location>
            <begin position="251"/>
            <end position="401"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PJN06675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="406" mass="44758" checksum="F862A9D4EAFC47A4" modified="2018-04-25" version="1">MDFAFDARTEELRAKLLAFMDEHVYPAEAVAHEQRAQLASPWDTPAVVEELKAEARRQGLWNLFLPDAEYGAGLTNLQYAPLAEITGRSPQLAPTALNCAAPDTGNMEVLSQFGDERQKKQWLEPLLAGEIRSAFAMTEPEVASSDATNITTLIERSADGSEYVITGRKWYISGAMNPDCKIFIVMGKTDPDGADIRRQQSMVLVPRDTPGLEIRRAMQVYGYEDHYHGGHAEVVFDQVRVPASNLIGEEGGGFAIAQARLGPGRIHHCMRLIGMAERAIELMCKRAVARTAFGKPLAQQGVVQEWIADARVAVEQLRLLVLKTAWLMDTVGNKGAHTEIQSIKIATPRTVVDIIDQAVQLHGAGGVSQDFPLAELWAGARTLRLADGPDEVHQRSLARRELKKYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JIH4</accession>
    <name>A0A2M9JIH4_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">DUF202 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CG723_38050</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CB01635</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000027">
        <property type="protein sequence ID" value="PJN06679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN06679">
        <property type="protein sequence ID" value="PJN06679"/>
        <property type="gene ID" value="CG723_38050"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003807">
        <property type="entry name" value="DUF202"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02656">
        <property type="entry name" value="DUF202"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="36"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="63"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="105"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="domain" description="DUF202" evidence="6">
        <location>
            <begin position="27"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PJN06679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="130" mass="14410" checksum="BCFE9B8AE7F01E39" modified="2018-04-25" version="1">MIEFVRSVRLWFAPERVREDGETPDYRFSLANERTFLAWLRTALALIGGGFAVDQFLPDLRWAWRAGLALALLAAGALCSLRAVSHWVRCERAMRRGEDLPVSRFPALLSVVVALVAVAMVVVVLAGWAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-09-29" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JIX6</accession>
    <name>A0A2M9JIX6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_36755</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000025">
        <property type="protein sequence ID" value="PJN06836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN06836">
        <property type="protein sequence ID" value="PJN06836"/>
        <property type="gene ID" value="CG723_36755"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002397">
        <property type="entry name" value="Cyt_P450_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00359">
        <property type="entry name" value="BP450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="SSF48264"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="65"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN06836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="423" mass="47108" checksum="E99F36C83A5FA965" modified="2018-04-25" version="1">MTEKPAQRTAPELFTWEFATDPYPAYAWLREHSPVHRTTLPSGVEAWLVTRYADAKQALADQRLSKNPAHHDEPAHAKGKTGIPGERKAELMTHLLNIDPPDHTRLRRLVSKAFTPRRVAEFAPRVQELTDRLIDEFAAKGEADLIHDFAFPLPIYAICDLLGVPREDQDDLRDWAGMMIRHGGGPRGGVARSVKKIRNYLVELIHRKRDEPGDDLISGLIRASDHGEHLTENEAAAMAFILLFAGFETTINLIGNGTYALLTHPEQRERLQLSLERGESGLLETGVEELLRYDGPVELATWRFATEPLTVGGQDISAGDPVLVVLAAADRDPARFEEPDTLDLSRRDNQHLGYGHGIHYCLGAPLARLEGQTALATLLTRLPDLRLAGEPADLRWRGGLIMRGLRTLPVEFTPHQEGPDKAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JJ94</accession>
    <name>A0A2M9JJ94_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Monooxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_36175</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000024">
        <property type="protein sequence ID" value="PJN06940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN06940">
        <property type="protein sequence ID" value="PJN06940"/>
        <property type="gene ID" value="CG723_36175"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016646">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002563">
        <property type="entry name" value="Flavin_Rdtase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01613">
        <property type="entry name" value="Flavin_Reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00903">
        <property type="entry name" value="Flavin_Reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flavin_Reduct" evidence="1">
        <location>
            <begin position="21"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN06940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="169" mass="17949" checksum="58AC01F02D66FC40" modified="2018-04-25" version="1">MLTHTTSQHSGLDAAHFRTVLGHFPSGITAITSRDAQGRPVGMTVASFTSVSLTPPLVAFLPGKSSSTFPVIAERGTFCVNILATDQERICRALSVSGGDKFAEVTWRPGPNGDPVIDGVVAWIGCTIEAVHDAGDHHIVIGRVDDLDADSTASPLLFFRSRYNHLVPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JJH8</accession>
    <name>A0A2M9JJH8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NUDIX hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_36455</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000024">
        <property type="protein sequence ID" value="PJN07020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN07020">
        <property type="protein sequence ID" value="PJN07020"/>
        <property type="gene ID" value="CG723_36455"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="SSF55811"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN07020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="149" mass="15879" checksum="85C1366836A4EDD8" modified="2018-04-25" version="1">METVLHRVRIGGGRTGVVVLARRGDDILLVRQWRPTIGRWAWELPRGFGESDPVSDALRELHEEAGLAASTAAVVAYLDVDSGLLESEVAVVEVQVPSDAPLRPDAACDGEVAAARWWSPSEIAESIRMGSLRDGFTLAAFGASSAAGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-06-02" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JJQ3</accession>
    <name>A0A2M9JJQ3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_35810</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000023">
        <property type="protein sequence ID" value="PJN07099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN07099">
        <property type="protein sequence ID" value="PJN07099"/>
        <property type="gene ID" value="CG723_35810"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="161"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="171"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN07099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="211" mass="22352" checksum="B40C3050A2974802" modified="2018-04-25" version="1">MPTPYGNRGGMAFGAEELRVLRRALALALHPSPVSAEDIQDCLRLAESVDEAADEGARIRAFLLADLARYRAALPGTTTGYLELLDESLAAGYQPGADDLASLRALRGNPSAATLLERCRTLTERDVRARLEGRASVRGEVRVLQPRVPASRTRLLALPGGLAATGKPASDPRPPANPPAPPRPMPTPAEVFPPKRRPAPPAAPPQELAVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JJU0</accession>
    <name>A0A2M9JJU0_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">T2SSF domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CG723_35375</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CB01635</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000023">
        <property type="protein sequence ID" value="PJN07133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN07133">
        <property type="protein sequence ID" value="PJN07133"/>
        <property type="gene ID" value="CG723_35375"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018076">
        <property type="entry name" value="T2SS_GspF_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00482">
        <property type="entry name" value="T2SSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="59"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="226"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="251"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="domain" description="T2SSF" evidence="7">
        <location>
            <begin position="112"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00482"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PJN07133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="285" mass="29158" checksum="1FEA20F3029CFFD3" modified="2018-04-25" version="1">MGPGCAALVCVGAAAWVAGGGHGREARRARELLGSGGGVPWGAQAWRVGWARWRERWEWWVLVVGAVLAVLGASVVPLVVGAAGVPLAARVRRDREGRRVRERRTDAVISLCGVLAGEVRAGRQPGEALIVAVREEGETRAGGSGAGDGAVVAAARFGGDVPGALGEAARAPGAEGLLGLAACWRVAVDRGAGLAAGLERLADALRSERDQRADLRAQLAGSRSTAVMLAGLPVLGLLLGSVLGARPLRVLLHTGAGFGCLLVGGVLEGAGLWWALRIVRGAEER</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-09-29" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JJX0</accession>
    <name>A0A2M9JJX0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Glycoside hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CG723_34815</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CB01635</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C40 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000022">
        <property type="protein sequence ID" value="PJN07170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN07170">
        <property type="protein sequence ID" value="PJN07170"/>
        <property type="gene ID" value="CG723_34815"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000064">
        <property type="entry name" value="NLP_P60_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00877">
        <property type="entry name" value="NLPC_P60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="SSF54001"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51935">
        <property type="entry name" value="NLPC_P60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014663950" evidence="2">
        <location>
            <begin position="41"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="domain" description="NlpC/P60" evidence="3">
        <location>
            <begin position="41"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PJN07170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="157" mass="17067" checksum="ED4EF3E0A13600BF" modified="2018-04-25" version="1">MTALNRVPSLLTRAGTASALTLAVAGGSLLVPGATPEAEASPPATKALQIAASRKGSPYQWGASGPHRFDCSGLTVYSFKRVGKKLPRTAAQQYNKTRHVSASHRKRGDLVFFHSGRGVYHVGIYAGKGRIWHSPKTGDVVRLQRIWTRSVWYGRVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JK57</accession>
    <name>A0A2M9JK57_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CG723_35270</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000022">
        <property type="protein sequence ID" value="PJN07250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN07250">
        <property type="protein sequence ID" value="PJN07250"/>
        <property type="gene ID" value="CG723_35270"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PJN07250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="55" mass="6251" checksum="C67EBB89512C0BCA" modified="2018-04-25" version="1">MALPAIDGRQYVYRVYAPDDALLADLFWDAWHCHDEGPFPRASDLFDAAVIERLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JKR1</accession>
    <name>A0A2M9JKR1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Catechol 1,2-dioxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_33700</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000020">
        <property type="protein sequence ID" value="PJN07453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN07453">
        <property type="protein sequence ID" value="PJN07453"/>
        <property type="gene ID" value="CG723_33700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008198">
        <property type="term" value="F:ferrous iron binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006725">
        <property type="term" value="P:cellular aromatic compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004183">
        <property type="entry name" value="Xdiol_dOase_suB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02900">
        <property type="entry name" value="LigB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LigB" evidence="1">
        <location>
            <begin position="10"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN07453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="319" mass="34926" checksum="58830B819120813B" modified="2018-04-25" version="1">MTEIVLGVGASHSTLMNTHWDQTFHKDRAERFRAALGEAREAIAKARPDTVVLVGSNHFRGFWLDLIPAFTLGVGECVASGESGTPKGPQAVDVPLARHLANSLVEGGRFDVAFSAKLQIDHGQSHAIQYLLDGLDVEIVPLVVNVFAHPLPTLARCEQLGRAIREAVLAFPGDRRVAVVGSGGLSHRLPWPDWREPHGEDEEFMVGAWLNGRDNWQEYDARRREIIRAAEAALNPEFDEEVLALIGRGEAHRLTAYSTEELEKVAGNGAQELRTWLLMAAALDHTPGRRLAYEPMPEWLTGMGVAVLDPGAPDPGPRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JKS7</accession>
    <name>A0A2M9JKS7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Lactate 2-monooxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CG723_33860</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CB01635</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the FMN-dependent alpha-hydroxy acid dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000020">
        <property type="protein sequence ID" value="PJN07480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN07480">
        <property type="protein sequence ID" value="PJN07480"/>
        <property type="gene ID" value="CG723_33860"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012133">
        <property type="entry name" value="Alpha-hydoxy_acid_DH_FMN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000262">
        <property type="entry name" value="FMN-dep_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037396">
        <property type="entry name" value="FMN_HAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008259">
        <property type="entry name" value="FMN_hydac_DH_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01070">
        <property type="entry name" value="FMN_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000138">
        <property type="entry name" value="Al-hdrx_acd_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00557">
        <property type="entry name" value="FMN_HYDROXY_ACID_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51349">
        <property type="entry name" value="FMN_HYDROXY_ACID_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0288">FMN</keyword>
    <keyword evidence="7" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FMN hydroxy acid dehydrogenase" evidence="6">
        <location>
            <begin position="20"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="4">
        <location>
            <position position="285"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="46"/>
        </location>
        <ligand>
            <name>glyoxylate</name>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="99"/>
            <end position="101"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="130"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="152"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="154"/>
        </location>
        <ligand>
            <name>glyoxylate</name>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="180"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="189"/>
        </location>
        <ligand>
            <name>glyoxylate</name>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="261"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="283"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="285"/>
        </location>
        <ligand>
            <name>glyoxylate</name>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="288"/>
        </location>
        <ligand>
            <name>glyoxylate</name>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="315"/>
            <end position="319"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="338"/>
            <end position="339"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00024042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000138-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000138-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PJN07480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="388" mass="41569" checksum="41C5AB49AC78E44A" modified="2018-04-25" version="1">MTQQFGDYQHEIYFNALGGIVPELPMAFAELEQRAGEALAPSVWSYVAGGAGDEFTQRENVTAFEQWGLVPRMFVGASRRDLTVDLFGLKLDSPLFMCPIGVIGLCGQDGHGDLATARAAARTGVPMVASTLSADPMEDVAKEFGETPGFFQLYTPTDRDLAESLVSRAEAAGFKGIVVTMDTWVTGWRPRDLTTGNFPQLRGHCLSNYTSDPVFRSRLPQGRADDTQAVVMQFASVFGNPLTWDDLPWLRSLTNLPLIVKGLCHPEDVRRAKDGGVDGIYCSNHGGRQANGGLAAIDALPEVVEAADGLPVLFDSGVRSGADVVKALALGATAVGIGRPYAYGLALGGVDGIVHVLRSLLAETDLIMAVDGYPTLADLTPQALRRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JKX6</accession>
    <name>A0A2M9JKX6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DNA-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_34040</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000020">
        <property type="protein sequence ID" value="PJN07508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN07508">
        <property type="protein sequence ID" value="PJN07508"/>
        <property type="gene ID" value="CG723_34040"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002878">
        <property type="entry name" value="DUF35_OB-fold_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022002">
        <property type="entry name" value="DUF35_Znr_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12172">
        <property type="entry name" value="DUF35_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01796">
        <property type="entry name" value="OB_aCoA_assoc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OB_aCoA_assoc" evidence="1">
        <location>
            <begin position="64"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="domain" description="DUF35_N" evidence="2">
        <location>
            <begin position="189"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="domain" description="OB_aCoA_assoc" evidence="1">
        <location>
            <begin position="225"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN07508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="315" mass="34245" checksum="25E92CBD2CC4AFC5" modified="2018-04-25" version="1">MPEVLKAPLVVEFPFTRSLGSVQSAFLTGLRERTVLGVKTTDGKVMVPPVEYDPVTADELRDLVEVESTGTVTTWAWNPEPRRGQPLGTPFAWVLVRLDGTDTALLHALDAPGPDAVTTGMRVRVRWAAERTGAITDIACFEPYEGEAADTEPAAHDGQFDDAVTGIVAAARLDYVYSPGRAQTAYINALADRRTVGERCPSCRKVYVPPRGACPTCGVATTDRVEVGPAGTVTTFCIVNVKARNLDIELPYVYAHIALDGADLALHGRIAGIPYDQVRMGLRVEPVWTEGGRYPDHYRPTGEPDADYDTYKELV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JKZ9</accession>
    <name>A0A2M9JKZ9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Xaa-Pro aminopeptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CG723_32790</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CB01635</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the peptidase M24B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000019">
        <property type="protein sequence ID" value="PJN07549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN07549">
        <property type="protein sequence ID" value="PJN07549"/>
        <property type="gene ID" value="CG723_32790"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.350.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007865">
        <property type="entry name" value="Aminopep_P_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029149">
        <property type="entry name" value="Creatin/AminoP/Spt16_NTD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036005">
        <property type="entry name" value="Creatinase/aminopeptidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000994">
        <property type="entry name" value="Pept_M24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001131">
        <property type="entry name" value="Peptidase_M24B_aminopep-P_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05195">
        <property type="entry name" value="AMP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00557">
        <property type="entry name" value="Peptidase_M24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01011">
        <property type="entry name" value="AMP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53092">
        <property type="entry name" value="SSF53092"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55920">
        <property type="entry name" value="SSF55920"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00491">
        <property type="entry name" value="PROLINE_PEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0464">Manganese</keyword>
    <keyword evidence="2 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP_N" evidence="7">
        <location>
            <begin position="56"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM01011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PJN07549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="489" mass="53803" checksum="04D07512DA9F2D3A" modified="2018-04-25" version="1">MSEELTPENPEIAQTESDEPIKQRKNGLYPGVSDELAESMKSGWADTELHGLEPIAQASETAARRAALSARFPGERIVVPAGNLKTRSNDTEYAFRASVEYAYLTGNQTEDGVLVLEPTISGHDATIYLLPRSDRENGEFWLDGQGELWVGRRHSLAEAEQVYGIPASDVRELAGHLAEASGPVRVVRGHDAGIEAALTDKVTREHDDELRVFLSEARLVKDAFEIGELQKAVDSTVRGFEDVVKILDKAEATSERYIEGTFFLRARVEGNDIGYGSICASGPHACTLHWVRNDGPVRSGDLLLLDAGVETHSLYTADVTRTLPVNGRYTELQKKIYDAVYEAQEAGIAAVKPGAKYRDFHDAAQHVLAEKLVEWGLVEGPVERVLELGLQRRWTLHGTGHMLGLDVHDCAVARTETYVDGTLEPGMCLTVEPGLYFQADDLTVPQEYRGIGVRIEDDILVTEDGNRNLSAGLPRRSDEVEAWMAQLKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JL26</accession>
    <name>A0A2M9JL26_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Deaminase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_33840</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000020">
        <property type="protein sequence ID" value="PJN07477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN07477">
        <property type="protein sequence ID" value="PJN07477"/>
        <property type="gene ID" value="CG723_33840"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008703">
        <property type="term" value="F:5-amino-6-(5-phosphoribosylamino)uracil reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009231">
        <property type="term" value="P:riboflavin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.430.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024072">
        <property type="entry name" value="DHFR-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002734">
        <property type="entry name" value="RibDG_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01872">
        <property type="entry name" value="RibD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53597">
        <property type="entry name" value="SSF53597"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RibD_C" evidence="2">
        <location>
            <begin position="27"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN07477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="202" mass="21389" checksum="1E443D3C08F35724" modified="2018-04-25" version="1">MPTAETPRNPDAASPITDTERQTASGKVLWHFTMSLDGFVAGPGHSMDWMTGFSSRPGLVEEYAQTTGAVLGGRDGWDAYPDASATYGGHWQGPVFVLTHRPEDLKPADGVTFLNCDVAEAVRIALDAAGGKNLEVLSPSIGRQLLERGLIDEIDLHIAPVLLGDGIRLFDNPGGSPVRLGLVNGSDPSLVVNVRYRPASAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JL70</accession>
    <name>A0A2M9JL70_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CG723_33210</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000019">
        <property type="protein sequence ID" value="PJN07626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN07626">
        <property type="protein sequence ID" value="PJN07626"/>
        <property type="gene ID" value="CG723_33210"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PJN07626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="154" mass="17258" checksum="8EB825D30CBD0B32" modified="2018-04-25" version="1">MCGLSCVHTLGTAKLSRLCPQGLVLNDHQTRSDGCGFVDKRSPQAVDKIFLHRVWVSLSTVDPQVRGPCAQLRAASPHSCPLFGNRTRGITVPSERRHIRACDWAVGNRGKAGDSPGEKWPRPVHRVCRTFPRPQRTPVVHRSRPQARWTKNRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JLF2</accession>
    <name>A0A2M9JLF2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">GNAT family N-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_32030</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000018">
        <property type="protein sequence ID" value="PJN07706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN07706">
        <property type="protein sequence ID" value="PJN07706"/>
        <property type="gene ID" value="CG723_32030"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="2">
        <location>
            <begin position="1"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="domain" description="N-acetyltransferase" evidence="2">
        <location>
            <begin position="146"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN07706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="274" mass="29609" checksum="99A74DDBA7C47B01" modified="2018-04-25" version="1">MTTTLRPTEPLQRDADGTRSRHYQVCVNSRPVGELRLGTHPVYGERVARIRDLRIDEPDRGRGRGTVAALAAEEVARGWGCGRIEVSIPAPAERALALATALGYVERNRNMEKDLPAEPSALPAGSAGRRMTGPEFTAWEAHTRVGYVRSLVERGVPEAQARAKAEVDHAATLGEGLATRDTVLSVLEADGAVVGTLWVALRGESAYVYDVEVAAEHRGHGHGRSLMLLAEAESRAAGTARLGLNVFAGNTPAVRLYESLGYRATEFHLYKPLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JLP4</accession>
    <name>A0A2M9JLP4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF4365 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_31975</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000018">
        <property type="protein sequence ID" value="PJN07697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN07697">
        <property type="protein sequence ID" value="PJN07697"/>
        <property type="gene ID" value="CG723_31975"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025375">
        <property type="entry name" value="DUF4365"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14280">
        <property type="entry name" value="DUF4365"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4365" evidence="1">
        <location>
            <begin position="34"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN07697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="188" mass="20632" checksum="60C481CC786F6B63" modified="2018-04-25" version="1">MALAQPEQGGLLPERIAPPRGTLATTACMETLQVGYLHAVAAAAGCSLSQPFPDNGIDWHVSHSAPGHTVDDEVTIKVQLKCTYQIPPKPPGPSFSFTLDNAHLEKLARTPVSVHKILVVMIVPRSQDDWLRAGHDRLDLRHCCYWINLAGQPVTGRRRTTVRIPTSRIFDDRALCEIMTRIGTGGRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JLQ0</accession>
    <name>A0A2M9JLQ0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ABC transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CG723_32470</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000018">
        <property type="protein sequence ID" value="PJN07782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN07782">
        <property type="protein sequence ID" value="PJN07782"/>
        <property type="gene ID" value="CG723_32470"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043215">
        <property type="term" value="P:daunorubicin transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1900753">
        <property type="term" value="P:doxorubicin transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005894">
        <property type="entry name" value="DrrA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025302">
        <property type="entry name" value="DUF4162"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13732">
        <property type="entry name" value="DUF4162"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01188">
        <property type="entry name" value="drrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="8"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="41"/>
            <end position="48"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PJN07782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="342" mass="36143" checksum="1E3F2B4321040F14" modified="2018-04-25" version="1">MSTRAPAVQARQLVKTYPGDVTALSGMDITVEPGTVFGLLGPNGAGKSTTVKILTTLARPDSGTATVAGHDVLRHPDRVRRAIGVVAQKSGADPVATGRENLQLQGRLYGLRGADLNRRVTELLDRFRLTDAAGRQVKGYSGGMQRRLDVALGLVHRPEVLFLDEPTTGLDPEARTAMWDEIARLAGDEGLSILLTTHYLEEADRLAERVAVVDRGHVVVEGTPDGLKGELRGDAVHLELRAAVQDAGRTLLESALAALPGVRETQFDGRRVSVRADDGAAAVPALLAALERAGVAVTAATVARPSLDDVYLRYAGRRYSEAQAATLDESAADTLAPAGGAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JLQ4</accession>
    <name>A0A2M9JLQ4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">4-amino-4-deoxychorismate lyase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CG723_32035</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CB01635</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000018">
        <property type="protein sequence ID" value="PJN07707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN07707">
        <property type="protein sequence ID" value="PJN07707"/>
        <property type="gene ID" value="CG723_32035"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008696">
        <property type="term" value="F:4-amino-4-deoxychorismate lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046656">
        <property type="term" value="P:folic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01559">
        <property type="entry name" value="ADCL_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017824">
        <property type="entry name" value="Aminodeoxychorismate_lyase_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001544">
        <property type="entry name" value="Aminotrans_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018300">
        <property type="entry name" value="Aminotrans_IV_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036038">
        <property type="entry name" value="Aminotransferase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043132">
        <property type="entry name" value="BCAT-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043131">
        <property type="entry name" value="BCAT-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01063">
        <property type="entry name" value="Aminotran_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56752">
        <property type="entry name" value="SSF56752"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00770">
        <property type="entry name" value="AA_TRANSFER_CLASS_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0456">Lyase</keyword>
    <keyword evidence="3 5" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU004106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PJN07707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="273" mass="29057" checksum="AB36A920E549FDE9" modified="2018-04-25" version="1">MKIWLDGALQEPEAARVSVFDHGLTVGDGIFETVRSVDGKPFALTRHLDRLARSARGLGLTEPDLDEVRRACDAVLEANPMPLGRLRITYTGGLSPLGSDRGEHGTTLVVALGEAGRRPDSTATVTVPWTRNERGALTGLKTTSYAENVVALARAREQGASEALFANTVGQLCEGTGSNVFVVLDGEVHTPPVASGCLAGITRALVVEWTGAKETDLPLDVLERADEIFLTSTLRDVQGVHRVDGRELPGAPGPVTAKAMRVFDERAADDLDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JLW5</accession>
    <name>A0A2M9JLW5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Dihydroxy-acid dehydratase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CG723_31200</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CB01635</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the IlvD/Edd family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000017">
        <property type="protein sequence ID" value="PJN07866.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN07866">
        <property type="protein sequence ID" value="PJN07866"/>
        <property type="gene ID" value="CG723_31200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016836">
        <property type="term" value="F:hydro-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019752">
        <property type="term" value="P:carboxylic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044238">
        <property type="term" value="P:primary metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042096">
        <property type="entry name" value="Dihydro-acid_dehy_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000581">
        <property type="entry name" value="DiOHA_6PGluconate_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020558">
        <property type="entry name" value="DiOHA_6PGluconate_deHydtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037237">
        <property type="entry name" value="IlvD/EDD_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00920">
        <property type="entry name" value="ILVD_EDD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143975">
        <property type="entry name" value="SSF143975"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00886">
        <property type="entry name" value="ILVD_EDD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PJN07866.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="586" mass="61325" checksum="D442ED3BF50256B0" modified="2018-04-25" version="1">MTDARLSHFAQNHQQQPGKSQAVSTELRSNHPIGSSRWATTRTQWKALGYNDEEIRRPKIAIVNSSSGLAPCFAHLDKVAEAVRQSVYDAGGLGFEIRTVAPTDFSMAAGRGGGYVLSGRDLVSYDIESVVEGAKLDGMICLASCDKTTPGQLMAAARTDVPTVIVACGYQSCGVLDNGRRVDIEEVFVDAGKLAAGAISFDDLCQMSDRAITGPGVCQGMGTANTMHIVAEALGMALPGSAPTQANSETMWAAAKAAGPVVMAAIEADRRPSTVMTPAAFRNAVTAVIAVSGSINAVKHLEAIAAESPYDIDVHRLFEEIGREVGPIAAVQPNGPTTIDEFDAAGGARGVLRQLGDRIDGSAMTVTGKPMAEAVAGAPVDAEVIRAEPMRAESTIVLMRGNLCPDSGIVKLSVTENRARTFRGTTRVFEAAPEATEAIERGEVLPGEVLVLRGLGVTGTPGMGMASNVVFALNGAGLSEQVAFVTDGQLSGLVNKGIVVGEISPEAGVPGPLGVVRTGDEIAIDVPNRTVDLLIDDEELNRRIEAYAETRAPQTWPARPGSWLGVYADAVEPLDRGATLRRTAAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JM95</accession>
    <name>A0A2M9JM95_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">GNAT family N-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CG723_30315</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000016">
        <property type="protein sequence ID" value="PJN07993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN07993">
        <property type="protein sequence ID" value="PJN07993"/>
        <property type="gene ID" value="CG723_30315"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PJN07993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="165" mass="19170" checksum="2836B239A5E3AD10" modified="2018-04-25" version="1">MSWLPDDFVHPVHVPVPHTALHLRPIREADTALDYPAVMGSQERLWEIFGPAWEWPKKTMTYEEDRIDLLRHEQEIAAHKSFNYALLDEEETAVLGCVYIDPPERTGSDGEISWWVVDDLVGSEAERALDALVPEWIATRWPFRQPRCLGREITWQEWLSLPPAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JMD8</accession>
    <name>A0A2M9JMD8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_31705</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000017">
        <property type="protein sequence ID" value="PJN07957.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN07957">
        <property type="protein sequence ID" value="PJN07957"/>
        <property type="gene ID" value="CG723_31705"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="22"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="46"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="78"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="114"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN07957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="239" mass="26137" checksum="B659E0E9DDEF985D" modified="2018-04-25" version="1">MPAHGRADAPVRHPRHQRRGEARLPGVLATLAAIALYLLLPQRLLIAPRYVVPALEFLLLVPLIAINPRRLTRQTRGFRILSLTLVTVIAASNLVALGLLIHELVYAGVKDGRGLLVAALQVWLTHIIVFGLAYWELDRGGPVNRTQTSRAQLPLADFRFSQDENADAVEEVADGASKTSDWVPTLVDYLYVSVTNSTAFSPTDTMPLSPRAKLLMTVESVSALLTSLLVIARAVSILR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JMZ6</accession>
    <name>A0A2M9JMZ6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CG723_30025</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000015">
        <property type="protein sequence ID" value="PJN08240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08240">
        <property type="protein sequence ID" value="PJN08240"/>
        <property type="gene ID" value="CG723_30025"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PJN08240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="107" mass="11233" checksum="FEBA5AC0D66C5EE9" modified="2018-04-25" version="1">MISINASFISTAKMTDRSVVASCLLGFSNLGTGASGIPAARPESFLSLADLPVRESNERPTKAPEAVATAQAQAYAFAAAGAGSRKQTTHHHTMWAFRGLEPWSDPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JNF7</accession>
    <name>A0A2M9JNF7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CG723_28915</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000014">
        <property type="protein sequence ID" value="PJN08402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08402">
        <property type="protein sequence ID" value="PJN08402"/>
        <property type="gene ID" value="CG723_28915"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008305">
        <property type="term" value="C:integrin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007155">
        <property type="term" value="P:cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.130">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013517">
        <property type="entry name" value="FG-GAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013519">
        <property type="entry name" value="Int_alpha_beta-p"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000413">
        <property type="entry name" value="Integrin_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028994">
        <property type="entry name" value="Integrin_alpha_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01839">
        <property type="entry name" value="FG-GAP"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01185">
        <property type="entry name" value="INTEGRINA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00191">
        <property type="entry name" value="Int_alpha"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69318">
        <property type="entry name" value="SSF69318"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51470">
        <property type="entry name" value="FG_GAP"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014799564" evidence="4">
        <location>
            <begin position="28"/>
            <end position="495"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PJN08402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="495" mass="49664" checksum="DD41DE671E769DD2" modified="2018-04-25" version="1">MRRAATAAAAVLAPLIAFALTSTTASATSPYKGANTAAVQDDFNGDGYRDLAVGAPYAANGSVEEAGAVVVLYGSASSVSTTHRTLVTQATSGVPGAPEEWDAFGATVASADLDRDGYADLIVGTPREQVGDKESRGSATVVWGGPSGLTGGATISPPAGYGDGRTYCGFGNSLATGDMNGDGAPEVTIGSRCEGASYTGPFTRTGKAASNYRESRLGETRGVVMGDVNGDGRAERFWLVGPADDDLRGPVYADNGPPTDDYLANWPTELPHADGHAGQIGDINGDGYGDLVTGVADDDSLMNATGAAHRGGEIQVLYGSAQGITVDQQPQVFHQGTAGVPGTAEDGDQFGQSLSVGDVNADGYADVLVGSPGEAVGTLKSAGTAVLLRGSASGLTATKAVGYTQSTADVPGAAEAGDWFGATVHLADLNKDGKAETVVGVPTENSDGCLWTARGSASGPVLSGSLNLCGKSAGITVRNTKGYFGAALPSPHVSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JNI1</accession>
    <name>A0A2M9JNI1_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 6">Extracellular small neutral protease</fullName>
            <ecNumber evidence="4 6">3.4.24.77</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CG723_29045</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CB01635</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>Hydrolyzes proteins with a preference for Tyr or Phe in the P1' position. Has no action on amino-acid p-nitroanilides.</text>
            <dbReference type="EC" id="3.4.24.77"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
        <text evidence="8">Binds 1 Ca(2+) ion per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="8">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 6">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 6">Belongs to the peptidase M7 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.77" evidence="4 6"/>
    <dbReference type="EMBL" id="NNBL01000014">
        <property type="protein sequence ID" value="PJN08423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08423">
        <property type="protein sequence ID" value="PJN08423"/>
        <property type="gene ID" value="CG723_29045"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000013">
        <property type="entry name" value="Peptidase_M7"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02031">
        <property type="entry name" value="Peptidase_M7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016573">
        <property type="entry name" value="Peptidase_M7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00787">
        <property type="entry name" value="NEUTRALPTASE"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0106">Calcium</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="6" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0964">Secreted</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="6 8" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014495696" description="Extracellular small neutral protease" evidence="6">
        <location>
            <begin position="30"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="110"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="active site" evidence="7">
        <location>
            <position position="158"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="150"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="152"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="157"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="161"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="167"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="173"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00019129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR016573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR016573-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR016573-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR016573-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PJN08423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="221" mass="22559" checksum="4F57868D277E0E3D" modified="2018-04-25" version="1">MKLSLRYASVAAGMALAAGALATAAPASAAPAPVGAGYTHYAGSAEEAAANKAFFQAVLKSVAEKRAANPGAASVTVTYDASGAPSFAQQIANSTSIWNSSVSNVKLQASSGGGDFSYREGNDPRGSYASTDGHGSGYVFLDYAQNQEYDSTRVTAHETGHVLGLPDHYEGPCSELMSGGGPGPSCTNPNPDANERARVDQLWANGFAKAMKSLKQSAKTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JNQ2</accession>
    <name>A0A2M9JNQ2_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Polyamine aminopropyltransferase</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Putrescine aminopropyltransferase</fullName>
            <shortName evidence="3">PAPT</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="3">Spermidine synthase</fullName>
            <shortName evidence="3">SPDS</shortName>
            <shortName evidence="3">SPDSY</shortName>
            <ecNumber evidence="3">2.5.1.16</ecNumber>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">speE</name>
        <name evidence="7" type="ORF">CG723_28705</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CB01635</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy-AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>putrescine + S-adenosyl 3-(methylsulfanyl)propylamine = H(+) + S-methyl-5'-thioadenosine + spermidine</text>
            <dbReference type="Rhea" id="RHEA:12721"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17509"/>
            <dbReference type="ChEBI" id="CHEBI:57443"/>
            <dbReference type="ChEBI" id="CHEBI:57834"/>
            <dbReference type="ChEBI" id="CHEBI:326268"/>
            <dbReference type="EC" id="2.5.1.16"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amine and polyamine biosynthesis; spermidine biosynthesis; spermidine from putrescine: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer or homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the spermidine/spermine synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.16" evidence="3"/>
    <dbReference type="EMBL" id="NNBL01000014">
        <property type="protein sequence ID" value="PJN08494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08494">
        <property type="protein sequence ID" value="PJN08494"/>
        <property type="gene ID" value="CG723_28705"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00248">
        <property type="reaction ID" value="UER00314"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004766">
        <property type="term" value="F:spermidine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008295">
        <property type="term" value="P:spermidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00198">
        <property type="entry name" value="Spermidine_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030374">
        <property type="entry name" value="PABS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030373">
        <property type="entry name" value="PABS_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001045">
        <property type="entry name" value="Spermi_synthase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01330">
        <property type="entry name" value="PABS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51006">
        <property type="entry name" value="PABS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 3 4" id="KW-0620">Polyamine biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0745">Spermidine biosynthesis</keyword>
    <keyword evidence="1 3 4" id="KW-0808">Transferase</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="12"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="47"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="78"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="115"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="151"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="180"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="214"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="domain" description="PABS" evidence="6">
        <location>
            <begin position="229"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="region of interest" description="S-methyl-5'-thioadenosine binding" evidence="3">
        <location>
            <begin position="364"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="474"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="3 4">
        <location>
            <position position="382"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="257"/>
        </location>
        <ligand>
            <name>S-methyl-5'-thioadenosine</name>
            <dbReference type="ChEBI" id="CHEBI:17509"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="288"/>
        </location>
        <ligand>
            <name>spermidine</name>
            <dbReference type="ChEBI" id="CHEBI:57834"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="310"/>
        </location>
        <ligand>
            <name>spermidine</name>
            <dbReference type="ChEBI" id="CHEBI:57834"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="330"/>
        </location>
        <ligand>
            <name>S-methyl-5'-thioadenosine</name>
            <dbReference type="ChEBI" id="CHEBI:17509"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PJN08494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="528" mass="55919" checksum="98022DEC9D3159C4" modified="2018-04-25" version="1">MAPLPVKPATGRFLVLAGVFLCAACGLVYELELVALASYLIGDSVTQASVVLSVMVFAMGIGSLGAKRLRLRAAAGFGAVEAALALVGGCSAMALYAVFAWTGDWGGSWAGGSRYMLVGFSLAIGVLIGAEVPLLMVLIQRIRRQDPGGAVADLFAADYVGALVGGLAFPFLLLPMLGQLTGALLTGAVNALAGGALVLGLFRRDLTRRGRWTLLVANVVVLGLLACAAVRVDDFERAARQAMYGRDVRVAVQTGVQEVVLTGGKHEPLGLYLDGRLRVSGRDEQRYHEGLVRPAMTGPHARVLILGGGDGLAAREVLRFPGVRQVDIVEIDPGVVRLARNDPPLSALNGHVYQDRRVRAVTGDAFQWLRGPHTPYDVVISDLPDPGITASTKLYSQEFYGLAAQVLAPDGRLAVHAGSLSSRPRVFWTVDTTLRAAGLRTVPYWVGTGEPPAPAGRQHGAWDRLTGIADGPDRTLDGTRAPSDWGFELASPRPLPEGAVPREQVRAAERSRITGLAPSTLVHPRYAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-09-29" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JP50</accession>
    <name>A0A2M9JP50_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MDMPI N domain containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_26465</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000012">
        <property type="protein sequence ID" value="PJN08644.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08644">
        <property type="protein sequence ID" value="PJN08644"/>
        <property type="gene ID" value="CG723_26465"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1320">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041916">
        <property type="entry name" value="Anti_sigma_zinc_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034660">
        <property type="entry name" value="DinB/YfiT-like"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109854">
        <property type="entry name" value="SSF109854"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN08644.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="444" mass="47949" checksum="A9B2B35952659D8E" modified="2018-04-25" version="1">MSGPNPFGNAEQPDNPDNRDNREGAGQPEGFEGAERPDAAANARIPTPRSSVEDTRRPLPDHLPEPLVLEHRVLKSLLGAWALAACSAAESVAVEEHLGDCGPCAEEALRLRDAVGLLHSEESLDLDPMLRSRVLEGCLTRRPPRIPVPEWAAPYDAETARLDALLQDIGDSEWHAPVRLRWYEGDDRVSRKTTVAGVLTHLMSVDGLVAVALGLDDPLFGVTPEERRTPESRTETFWKASHFPPTRAVRGPWREQSHAVIRTVSFAADPGSSSGRTRTSGQLAVPYGDFTLPLRDSMLDRAFECWVHAEDIAEAVDYPYEPPSARHLNRMIDLAARLLPDSLAGRRRAGLAAPARSLVAAGAPGRTLRLEVEGAGGGEWLIALDSPGAVGSEEHEVAHVALDGAEFCRLAAGHVTPEEAAAGQDGDREAIHDVLYATAALSRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JQI9</accession>
    <name>A0A2M9JQI9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Two-component sensor histidine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CG723_24685</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CB01635</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000010">
        <property type="protein sequence ID" value="PJN09115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN09115">
        <property type="protein sequence ID" value="PJN09115"/>
        <property type="gene ID" value="CG723_24685"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="5">
        <location>
            <begin position="162"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="381"/>
            <end position="425"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PJN09115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="425" mass="44992" checksum="7DBF210F0DC53E81" modified="2018-04-25" version="1">MDVNAAVAAAAAIAGVCTGVIAMLAFRWSERDQKRPTRTSLHTDPVLPPGVDTVLSVLRSSAVVLDEADSVVKASSAAYALGLVRGGKLAVEPMLLMARDTRRDGEIRQVELDLPRRGTGRGDALAVSARVAPLGSRLVLLLVEDLTEARRIEAVRRDFVANVSHELKTPVGALSLLSEAVMDASDDPEAVERFAGRMQIEATRLTNLVQELIDLSRVQNDDPLEDAEPVRVDELVAEAIDRCRHQAGTKQITMAAGGTADLQIWGNRGQLAAALGNLVENAVNYSPARTRVGIAARRVTAPGGDLIEVAVTDQGLGISDKDKERIFERFYRVDPARSRATGGTGLGLAIVKHVAASHGGEVTVWSSEGQGSTFTLRLPEAGATRDRGPGHVGGDAYGHHVGNDADGPDETTAYDPIPAAPEVLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-09-29" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JQW3</accession>
    <name>A0A2M9JQW3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Allantoin permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CG723_23150</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CB01635</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the purine-cytosine permease (2.A.39) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000009">
        <property type="protein sequence ID" value="PJN09254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN09254">
        <property type="protein sequence ID" value="PJN09254"/>
        <property type="gene ID" value="CG723_23150"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001248">
        <property type="entry name" value="Pur-cyt_permease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026030">
        <property type="entry name" value="Pur-cyt_permease_Fcy2/21/22"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31806">
        <property type="entry name" value="PTHR31806"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02133">
        <property type="entry name" value="Transp_cyt_pur"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002744">
        <property type="entry name" value="Pur-cyt_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="34"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="62"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="118"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="146"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="177"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="209"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="251"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="291"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="332"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="363"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="403"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="446"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR002744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PJN09254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="491" mass="51414" checksum="6502061E6945B939" modified="2018-04-25" version="1">MAASTKNDRVGTVETRGIEPVPDTERHGHASQMFWTWFAANISILGLPLGATLVAFRGLNIWQAALVAVVGSVGSFALVGALSLAGKKGGAPALTLSRAVFGQRGNHGPTLMTWLSRVGWETITTTTAAYALLALLNTLFGVGKGTVLTLVCLLVFILCTLLISGLGHATIMWINKWATVAFGVLNLVVMGFLVATVDWQKVLDAPAGRASAVVAGIGFIASGTGIGWANAGADYARYLPRSIPGGRLVRASAFGAGIPLVLLISLGSLLTAGDPSLATSADPVAAINAMLPSWMAVPYLIAAFGGLLMSNHLSTYSAGLTMITLGLRVPRAWAVCIDIVLMFLGGIYFMLIADDFYGPFSTFLTLLAVPISAWIGVIAVDMLRGREYDPSALMNTGRGSRYWYRGGFHLPAVTAWLAAIVAGLLFTTAATSADDVWFKGPLADSWLGVNGLGWLIAIVVGGALYALLGRRSQVTLTTPAADSTTLEEAAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JQY7</accession>
    <name>A0A2M9JQY7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Crotonase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_23340</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the enoyl-CoA hydratase/isomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000009">
        <property type="protein sequence ID" value="PJN09289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN09289">
        <property type="protein sequence ID" value="PJN09289"/>
        <property type="gene ID" value="CG723_23340"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.12.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018376">
        <property type="entry name" value="Enoyl-CoA_hyd/isom_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014748">
        <property type="entry name" value="Enoyl-CoA_hydra_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00166">
        <property type="entry name" value="ENOYL_COA_HYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN09289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="262" mass="28885" checksum="B1A6316E13826B09" modified="2018-04-25" version="1">MAVEDEIQFERDGHVARVWLNRPWKKNCVTVPILDRLDEIITEVDEDPELRVLVFRGRGGTFCSGFDLDSLKADFVGKSNAIDVAVKSAKVCDRLYSMKTPSVAVLEGYVTAGGFEIMISCDFAIAADDAKIGDFHIRRSLFGGAGPIYRVPRMIGIRKTKELMLTGKLLSGTEAAEFGLINKSAPADELDATVEDFIGDLTDKSPFTMWLTKMTIDRSLDADTQSLMVMEHLAVGVALNSEDAAEGVSAFLEKREPKWQGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-09-29" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JR71</accession>
    <name>A0A2M9JR71_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Acetyl-CoA acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CG723_23330</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CB01635</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the thiolase-like superfamily. Thiolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000009">
        <property type="protein sequence ID" value="PJN09287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN09287">
        <property type="protein sequence ID" value="PJN09287"/>
        <property type="gene ID" value="CG723_23330"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002155">
        <property type="entry name" value="Thiolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020617">
        <property type="entry name" value="Thiolase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020616">
        <property type="entry name" value="Thiolase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02803">
        <property type="entry name" value="Thiolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00108">
        <property type="entry name" value="Thiolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000429">
        <property type="entry name" value="Ac-CoA_Ac_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Thiolase_N" evidence="2">
        <location>
            <begin position="5"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="domain" description="Thiolase_C" evidence="3">
        <location>
            <begin position="259"/>
            <end position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU003557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PJN09287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="381" mass="39390" checksum="444603418ED05862" modified="2018-04-25" version="1">MSTDVLICGAGRTPFGRSEASGRQLAVSAVGAALADAGIDWSRVRAAFGGSDSAGLADTLVAQLGLTGLPFVNVKNGCATGGSALISAVNAIRSGMADVVLAVGFDKHPRGAFDPRPEDWGLGAEYGSDGLMVTTQFFGMKIQRYMYEHGITPQTLAQVAEKAYRNGARTPEAWRRKPVSAAEILDSGMVSDPLTRFMFCSPGAGAAALVLCSPEVARTLDGPSVTLRSAALRTRRFGSFEVFSPSIPGGEPTSVSRDAAAAAFEEAGIGPGEVDVCQLQDTESGAEVMHMAECGFCKDGEQERLVASGATEIGGSLPVNTDGGCIANGEPIGASGLRQVYEIVQQLRGRAGERQVPGTPRVGFTHVYGAPGVSACTVLAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JRB7</accession>
    <name>A0A2M9JRB7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Short-chain dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CG723_23255</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000009">
        <property type="protein sequence ID" value="PJN09419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN09419">
        <property type="protein sequence ID" value="PJN09419"/>
        <property type="gene ID" value="CG723_23255"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PJN09419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="252" mass="26156" checksum="70F9A620C7329B27" modified="2018-04-25" version="1">MRDRLSGQIALVTGATGGIGDAVSRRLAAEGATVVVTDVDAGRCEELAKELTAGGARALGLALDVSDEDAWRGAVDRVVAELGGLTVLVNNAGIAEMRTVETETQESWDKVISVTQGGVWLGMKHGGPAIERSGGGSIVNIASIFGTVGGFGSQFSYHAAKGAVRLMTKNAALHWATLGVRVNSLHPGFIETPLSRELWRGTPRHTAMVEGTPMARLGRPDEVAGAVAFLASADASFVTGSELYVDGGWTAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JRF2</accession>
    <name>A0A2M9JRF2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Formyl-CoA transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_22015</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000008">
        <property type="protein sequence ID" value="PJN09455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN09455">
        <property type="protein sequence ID" value="PJN09455"/>
        <property type="gene ID" value="CG723_22015"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10540">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003673">
        <property type="entry name" value="CoA-Trfase_fam_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044855">
        <property type="entry name" value="CoA-Trfase_III_dom3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023606">
        <property type="entry name" value="CoA-Trfase_III_dom_1_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02515">
        <property type="entry name" value="CoA_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89796">
        <property type="entry name" value="SSF89796"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="350"/>
            <end position="379"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN09455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="406" mass="44213" checksum="C3F8179E15CF8F25" modified="2018-04-25" version="1">MENTPLLEGLHVVDIASFIAGPAAATILGDYGADVVKVEPPHTGDSYRGLSRMPPNPQVEGVNYPWQLDNRNKRSIELNLKSSDARSVLERLVRWADVLVTNFPPRTRAKLGLDYDDLSSVNPRLIYADVTGFGEEGPDAHLPGFDVTAFWARSGLMDFTRQRDAAPAINVFGSGDHPTAITLFAGIMTALYRREKTGQGARVSASLIAEGAWAAGMWLQAALLGGKPPRPVERSDPPNALANVYRTADDRWILLAFANEGKEVPLFLEAIGHPEAVEDPRFHDTVSRRAHAAEIVTLLDKRFATRPLAEWREVLDAAGLTYGVVQTLEECAHDPQLLANQIVVPIEDGSSEPHLTLNSPVHLDQEQKVPPRPAPDLGEHNEEVLSELGFSTDDIASLRTGGAIPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JRG9</accession>
    <name>A0A2M9JRG9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">NAD(P)-dependent oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_22150</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000008">
        <property type="protein sequence ID" value="PJN09475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN09475">
        <property type="protein sequence ID" value="PJN09475"/>
        <property type="gene ID" value="CG723_22150"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021295">
        <property type="entry name" value="DUF2867"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016040">
        <property type="entry name" value="NAD(P)-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11066">
        <property type="entry name" value="DUF2867"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13460">
        <property type="entry name" value="NAD_binding_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD(P)-bd_dom" evidence="2">
        <location>
            <begin position="17"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="484"/>
            <end position="508"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN09475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="508" mass="56129" checksum="CE1CDDB991869159" modified="2018-04-25" version="1">MCTVPPEVGPRGACVSLKAGHRVRCLARSPRKLRDHPWAGDTEVLHGDVTDAESVAAAMRGVDVAYYLVHSLGSGSGFEDTDRRAARIFAERAHAAGVRRIVYLGGLTPQDVPEQDLSPHLRSRAEVGRIFLDAPVPATVLRAGVVIGSGSASFEMLRYLTERLPVMVTPSWVHTRTQPIGVRDVLRYLVGSATMPTDVDRAFDIGGPDVLTYREMMRRYSEVAGLRRRIILPVPVLTPRLSSHWVGLVTPVPASIARPLTESLRHEVVCHEHDIACYVPDPPGRPLPFDEALALALRRVREAQVATRWSSAALPGAPSDPLPTDPDWAGGSLYEDERQLPVEASREALWKVIEGIGGDNGWYSFPLAWAVRGWLDRFVGGVGLRRGRRDAERLRVGDSLDFWRVEEIEPLQLLRLRAEMRLPGLAWLEMYVETGAEGGTRYRQRALFHPRGLLGHAYWWSVSPFHAVVFGGMARNITQAAAKGMSAPGAPKHPACARRPRIGRRLPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JRP2</accession>
    <name>A0A2M9JRP2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_22665</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000008">
        <property type="protein sequence ID" value="PJN09546.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN09546">
        <property type="protein sequence ID" value="PJN09546"/>
        <property type="gene ID" value="CG723_22665"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="35"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="63"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="106"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="141"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="187"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN09546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="238" mass="25162" checksum="B4547170673976FF" modified="2018-04-25" version="1">MSAAQAGSPGAALPRASRVFGDGPLSRACALIHTLLTVEGLLLLTLAPSLLGLLFLGADPANLPLAALCLAPLGPALSAALYALHHRSRDLTELRPARAYLRGLRLNSAAALRIWVPLLAWLTVIAYGLTHFASTALPGWWAVLLEVIGVGALLWGAHALVLTSLFTFRVVDTARLAGYFLLRHGRATLGAASLLVVATAATLWWTEALPLLLAPVLLLSLLHTSRPIIAETQEDFTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JRS3</accession>
    <name>A0A2M9JRS3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CG723_22895</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000008">
        <property type="protein sequence ID" value="PJN09585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN09585">
        <property type="protein sequence ID" value="PJN09585"/>
        <property type="gene ID" value="CG723_22895"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PJN09585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="326" mass="34739" checksum="B4A0B40EA0385EC6" modified="2018-04-25" version="1">MTHKQHPIGSGFTAASTAEEVAAGIDLTGKNVIITGGHAGLGREVTRVLVNAGASVTVGSRNPQRAREALADIEGVEVSRLDLMDPASIDTFAERRLDTHRPLHILINCAGLPAPAQRELDARGYEAQFATNHLGHFQLTLRLLPALRATHGARVVNVTSGAQRFSDIRWDDLHFADGYGPTAAYAQSKTANVLFAVELDRRWAKDGIRGYATHPGVVVGTSLNSATGQEGLRAMGLIDEAGQPIIDPEAGKKTLQQGAATIVFAATSPLLADIGGVYLKDSDISRLDDEPKPLTADSIPSEVASHSIDPKSARRLWELSEHMLTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JRZ8</accession>
    <name>A0A2M9JRZ8_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Proline dehydrogenase</fullName>
            <ecNumber evidence="3">1.5.5.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CG723_20805</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CB01635</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a quinone + L-proline = (S)-1-pyrroline-5-carboxylate + a quinol + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23784"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17388"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:60039"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
            <dbReference type="EC" id="1.5.5.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="7">Binds 1 FAD per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid degradation; L-proline degradation into L-glutamate; L-glutamate from L-proline: step 1/2.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.5.5.2" evidence="3"/>
    <dbReference type="EMBL" id="NNBL01000007">
        <property type="protein sequence ID" value="PJN09655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN09655">
        <property type="protein sequence ID" value="PJN09655"/>
        <property type="gene ID" value="CG723_20805"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00261">
        <property type="reaction ID" value="UER00373"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004657">
        <property type="term" value="F:proline dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010133">
        <property type="term" value="P:proline catabolic process to glutamate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029041">
        <property type="entry name" value="FAD-linked_oxidoreductase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008219">
        <property type="entry name" value="PRODH_bac_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002872">
        <property type="entry name" value="Proline_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015659">
        <property type="entry name" value="Proline_oxidase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13914">
        <property type="entry name" value="PTHR13914"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01619">
        <property type="entry name" value="Pro_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000196">
        <property type="entry name" value="Pro_dehydrog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51730">
        <property type="entry name" value="SSF51730"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0274">FAD</keyword>
    <keyword evidence="7" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pro_dh" evidence="8">
        <location>
            <begin position="51"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="98"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="163"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="187"/>
            <end position="189"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="201"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="226"/>
            <end position="227"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="288"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="289"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000196-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000196-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PJN09655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="308" mass="33859" checksum="73E78151382DCA96" modified="2018-04-25" version="1">MLGPVILAASRSDKMRRFISAAPGTKQVVDRFIAGESVDDVVPIVVDACGKGLEVTLDVVGEDITTPEQAAAARDAYLELIAHLEDLGLGTKAEMSVKLSMFGQALDGGHELALANVRPVVEAAAAIGTTVTLDAEDHTTLDSMFAIHEELRKDFPQTGCVIQAYLFRTEDDATRLAAAGSRVRIVKGAYKEPASVAYQDKAEIDKAYVRILKILMEGDGYPMIGSHDPRLISISQELARRAGRKLDEYEFQMLYGIRSDEHVRLAAEGHRMRVYTAYGTDWYGYFMRRLAEKPANLLFFARSILTKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JSA2</accession>
    <name>A0A2M9JSA2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">GntR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_21255</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000007">
        <property type="protein sequence ID" value="PJN09732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN09732">
        <property type="protein sequence ID" value="PJN09732"/>
        <property type="gene ID" value="CG723_21255"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041444">
        <property type="entry name" value="HTH_41"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032791">
        <property type="entry name" value="YhfZ_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14502">
        <property type="entry name" value="HTH_41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14503">
        <property type="entry name" value="YhfZ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH_41" evidence="1">
        <location>
            <begin position="31"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="domain" description="YhfZ_C" evidence="2">
        <location>
            <begin position="81"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14503"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN09732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="312" mass="33919" checksum="C207CD57CCF5CDC8" modified="2018-04-25" version="1">MNGFDERFLTRNGLAARQLAVLLLNHEPDTRLPRIRDFAEELGCGNGTVQAALRLLEESGAIETAARGHLGTFLVRSERSILWRLSGLGTLLAAMPLPYSRRYEGLATGLRAAFEEAGTPFAITFMRGAGARTTALLEGKVDLVILSRFAADRLIEEYPVELVADLGPATYVGAHGLLLREGASLDAPGLRVAVDHTSEDQRMLAERAFARRTDIEWVESSYMQLRDLFAQNLADATVWNLDEVQGRIGMGGEVLPLGDEVTRDLSLRNSSAAIIGRTEGAKALSAVRNAVDLSTVTSLQAEVLRGERVPSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JSA3</accession>
    <name>A0A2M9JSA3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">SAM-dependent methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_21265</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000007">
        <property type="protein sequence ID" value="PJN09734.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN09734">
        <property type="protein sequence ID" value="PJN09734"/>
        <property type="gene ID" value="CG723_21265"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="95"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="95"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN09734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="287" mass="30654" checksum="018AB0725509BFCC" modified="2018-04-25" version="1">MTPTLVQRHLPHAGRVPRVDLCARARDWAEIQERMLVPLYEAVYERLEVGDGAGTRLLGLGCGSGLALLMAASRGAAVTGVEAAAPERLALARERLQGETRGTRARGDTRLTEGGPEDAAQPDDPPYNLITAFQPIGCTAGDSEGLGALLESASPFAERGTPVVLAGWGPPERCATSSVLRVATKLADPLRSTGSWRPALRDDLEEVTHRAGLRPDGSGRVACPFGYADVDSAVRGLLSTGLFDAAIGATDRSQVEKEMTEALHPHQRRDGTVWMPNVFRYVIARTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JSA5</accession>
    <name>A0A2M9JSA5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Mg chelatase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_21340</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000007">
        <property type="protein sequence ID" value="PJN09749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN09749">
        <property type="protein sequence ID" value="PJN09749"/>
        <property type="gene ID" value="CG723_21340"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045006">
        <property type="entry name" value="CHLI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004482">
        <property type="entry name" value="Mg_chelat-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025158">
        <property type="entry name" value="Mg_chelat-rel_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000523">
        <property type="entry name" value="Mg_chelatse_chII-like_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32039">
        <property type="entry name" value="PTHR32039"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32039:SF7">
        <property type="entry name" value="PTHR32039:SF7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01078">
        <property type="entry name" value="Mg_chelatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13335">
        <property type="entry name" value="Mg_chelatase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mg_chelatase" evidence="1">
        <location>
            <begin position="213"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="domain" description="Mg_chelatase_C" evidence="2">
        <location>
            <begin position="428"/>
            <end position="524"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN09749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="539" mass="55777" checksum="4F57B63146EEA203" modified="2018-04-25" version="1">MGFARTCSVALVGVEGVVVEVQADLEPGVAAFTLVGLPDKSLSESRDRVRAAVVNSGGEWPQKKLTVGLSPASVPKSGSGFDLAIASAVLGAAERIDPRVLSDVVMIGELGLDGRVRPVRGVLPAVLAAADAGYEQVVVPECSAGEAALVPGVSVLGVRSLRQLIAVLTDEPVPDEPPDETGRPDPMLAGLSIPGQGLGVGLAGMPHDAHILDLADVVGQRAARTAIEVAAAGAHHVLLQGPPGAGKTMLAERLPLVMPPLTREEALEVTAIHSVAGMLPPGKPMVDSAPYCAPHHSATMQSLVGGGQGMPRPGAVSLSHRGVLFLDEAPEFSGQALDALRQPLESGHVVIARSAGVVRLPARFLMALAANPCPCGNHSLVGGGCECPPAAVRRYQARLSGPLLDRVDLRVDVEPVTRAELTGSGAQGETTAVVRERVRAARERGAARLADTPWRTNSEVPGHALRTRWPAAPGAMDDVETDLERGFLTARGVDRVLRVAWTVADLCGRDRPRAQDVALALQLRTGISHGVAMALGGSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JSB2</accession>
    <name>A0A2M9JSB2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CG723_21505</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CB01635</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000007">
        <property type="protein sequence ID" value="PJN09775.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN09775">
        <property type="protein sequence ID" value="PJN09775"/>
        <property type="gene ID" value="CG723_21505"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="73"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="105"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="133"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="234"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="67"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PJN09775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="265" mass="28875" checksum="A9BF888329679AB8" modified="2018-04-25" version="1">MPFVRWLRRNLVVIAGLVTLGYLLLPNVIVTVFSFNKPKGRFNYEWQQFSLDAWTNPCGVADMCGSLSLSLQIALWATIGATVLGTMIAFALVRYRFRARGAVNSLIFLPMAMPEVVMAASLLTLFLNMGAQLGFWTILIAHIMFCLSFVVTAVKARVMSMDPRLEQAAQDLYAGPVQTFVRVTLPIAAPGIAAGALLAFALSFDDFIITNFNAGSTVTFPMFVWGSAQRGTPVQINVIGTAMFIVAVLLVLAAMLIGKRKNKAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JSH0</accession>
    <name>A0A2M9JSH0_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">30S ribosomal protein S16</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">rpsP</name>
        <name evidence="5" type="ORF">CG723_21280</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CB01635</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the bacterial ribosomal protein bS16 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000007">
        <property type="protein sequence ID" value="PJN09737.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN09737">
        <property type="protein sequence ID" value="PJN09737"/>
        <property type="gene ID" value="CG723_21280"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1320.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00385">
        <property type="entry name" value="Ribosomal_S16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000307">
        <property type="entry name" value="Ribosomal_S16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020592">
        <property type="entry name" value="Ribosomal_S16_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023803">
        <property type="entry name" value="Ribosomal_S16_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12919">
        <property type="entry name" value="PTHR12919"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00886">
        <property type="entry name" value="Ribosomal_S16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54565">
        <property type="entry name" value="SSF54565"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00002">
        <property type="entry name" value="S16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00732">
        <property type="entry name" value="RIBOSOMAL_S16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="1 3 5" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="105"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="105"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PJN09737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="145" mass="15937" checksum="DBE24D3E4E8D0969" modified="2018-04-25" version="1">MAVKIKLKRLGKIRSPHYRIVVADSRTRRDGRAIEEIGLYHPVQNPSRIEVNSERAQYWLSVGAQPTEPVMAILKLTGDWQKHKGLPAPAPLLVAEPKDKRAAFEAFSKGLEGDDAKGEAITPKAKKADKKADEAPAESTESTEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JSL1</accession>
    <name>A0A2M9JSL1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">TetR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CG723_19165</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000006">
        <property type="protein sequence ID" value="PJN09866.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN09866">
        <property type="protein sequence ID" value="PJN09866"/>
        <property type="gene ID" value="CG723_19165"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="3">
        <location>
            <begin position="25"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="47"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PJN09866.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="201" mass="21622" checksum="064E2CDF85780A0B" modified="2018-04-25" version="1">MTTGTDQTDRPRPAPSVRPMRADARRNYERLLAEARTAFAEHGTGASLEDVARRAGVGIGTLYRHFPNRHALMSAVFEDAVNDLLARSRALLADPQPCSALVAWLRDIITHAGEYRGLSRALMSASHDASSALSRCSTPMREAGQALLSRAQRAGAVRADVSIGDLLQLTNAIALAAEETPDDPELADRLLRLTLRGITAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-09-29" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JSQ1</accession>
    <name>A0A2M9JSQ1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Acyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CG723_19380</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000006">
        <property type="protein sequence ID" value="PJN09905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN09905">
        <property type="protein sequence ID" value="PJN09905"/>
        <property type="gene ID" value="CG723_19380"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002656">
        <property type="entry name" value="Acyl_transf_3_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01757">
        <property type="entry name" value="Acyl_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="75"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="118"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="159"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="191"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="221"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="244"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="277"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="303"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="340"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl_transf_3" evidence="3">
        <location>
            <begin position="32"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PJN09905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="381" mass="41883" checksum="1E480F16A4686F02" modified="2018-04-25" version="1">MSTSQTTLPKLSPGADATVRSARPRAHAPRLRALDGLRLIAALMVAAYHYGGRDGEVSQAWGTSPKVQFPSLHQWFAYGCLGVQIFFVISGFVICMSGWGKPLRSFFASRASRLLPSYWAAVILVTAVFALPVVAYKAVSPSDALLNLTMLQQPLGVDRVLGVCWTLWAEVRFYALFALCIVLPGANRRRVVLFCAVWTLAAAITQASGEPALKVILMPEYAPYFIGGVGLYLLHLNHRDMTAWGIVLVSWLIGQHYAVAALWHAPNPHFFSYRGSGSIILIVTLGFVAVGAIALGLLNRINWGWLTVAGALTYPFYLVHEHLGWVVIEMLHRRLGLPSAVTFTLTVAAMLTLAWLLNRFAEKPLAPFLRKQLNPTPARIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-06-02" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JSZ4</accession>
    <name>A0A2M9JSZ4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_19805</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000006">
        <property type="protein sequence ID" value="PJN09973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN09973">
        <property type="protein sequence ID" value="PJN09973"/>
        <property type="gene ID" value="CG723_19805"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="83"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="208"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN09973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="222" mass="21912" checksum="84D2A6E5C7F864A1" modified="2018-04-25" version="1">MEPTRDRVVEPVRTHVTEPVRTQVAAPVVRGVRDVRGTVQGAVREEVREVGEFAVGILGGLAAEAPPQFLPGPPSMPGLPGIPGQIGAPGAPGQPGNGAHTAPAPGVGAHAAAGHSDRARPGKREAAVPVGDVFASAGDNVVPARTPATKAAGSPTPAPAPAFPSGSAVGQSAGDGSTTRHSDLAAAAFGSGATARLLPGATGSSHAAPTRDRHRDIPEFPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JTJ7</accession>
    <name>A0A2M9JTJ7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_17650</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000005">
        <property type="protein sequence ID" value="PJN10221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN10221">
        <property type="protein sequence ID" value="PJN10221"/>
        <property type="gene ID" value="CG723_17650"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014644124" evidence="2">
        <location>
            <begin position="43"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="35"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="135"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="37"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="135"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN10221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="199" mass="19860" checksum="459F9C4FEBFF658D" modified="2018-04-25" version="1">MAATESARRLLPGHSQRRRAAGIVLAALVTLTMGGCGSTDKAEQESSPSRQTSKAPSSKAPSSKAPSSKAPSPRPSSAQPSVSAADGRDVGACADGNCEIAVTGPVTFRFKGPTGPATLSVTEVGPNKVEYTIKSGNSQSQGGASGPGQSCITVLRSNGSGNSCGGQGDAARPSPQPDAVLIQAVTNENGTAILRIVSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JTR6</accession>
    <name>A0A2M9JTR6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Sensor histidine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CG723_17695</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000005">
        <property type="protein sequence ID" value="PJN10228.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN10228">
        <property type="protein sequence ID" value="PJN10228"/>
        <property type="gene ID" value="CG723_17695"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025828">
        <property type="entry name" value="Put_sensor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011712">
        <property type="entry name" value="Sig_transdc_His_kin_sub3_dim/P"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07730">
        <property type="entry name" value="HisKA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13796">
        <property type="entry name" value="Sensor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="41"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="68"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="134"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="200"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="domain" description="HATPase_c" evidence="3">
        <location>
            <begin position="367"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PJN10228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="457" mass="47786" checksum="3901EDFC2FE5ADDD" modified="2018-04-25" version="1">MHESAGDRPPEGARAEPSRQVSPGAVLRAPFTARAWAEATYCLVGFPLAVVGAVLLLVLLALGTGLTASLVGAVLGLALVVGAVGLARGCAAVHRRLAQVLLDERVDAPPRLRPTGKAFARLDARLRDAAGWRAVAYVLVKLPVAAFGLYAVGWWLTALLNLSAPLRWAAFHQRPAAGEAGMPTITPIPVGGGAPHSTSFAGTFVAAAIGAVTLLAAPWFTRGVVAVDRWLIRALLGPGQLAERVRSLEESRALAVDDSAALLRRLERDLHDGAQVRLVALAMSLDMAKERLGPEGEPIADPARVRQLVDTAHRNATEALAELRDLARGIHPPALDDGLADALSTLAARSTVPVELSVDVPQRPTPAIEAIAYFCAAELLTNVIKHSGARRAVLWVAQVDDVLRLRVTDDGRGGAALGAGSGLTGLQQRVRTVDGRLDLSSPSGGPTAVTVELPLHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JTS6</accession>
    <name>A0A2M9JTS6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">S-adenosyl methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CG723_17945</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000005">
        <property type="protein sequence ID" value="PJN10274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN10274">
        <property type="protein sequence ID" value="PJN10274"/>
        <property type="gene ID" value="CG723_17945"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006764">
        <property type="entry name" value="SAM_dep_MeTrfase_SAV2177_type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04672">
        <property type="entry name" value="Methyltransf_19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017393">
        <property type="entry name" value="MTase_SAV2177"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PJN10274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="271" mass="29149" checksum="8268F736C91F50F3" modified="2018-04-25" version="1">MTDDATTPGAAAHQKIDTSVPHSARIWNYWLGGKDNYPVDEEAGDAYSAVFPGISTIARSSRAFLRRNISYLVTEAGIRQFLDVGTGLPTGDNTHEVAQRLAPETKIVYVDHDPMVLAHARALLTSTPEGATAYVDANLSDPDRILAAAAETLDFTRPTALILSNILGHMGDYEQARTIVKRLMDGLPSGSYLSINDGSRGFDAGFEAAQDGYNSSGAVPYFLRPVDEITAFFDGLELLEPGVVSVPFWRPESTSPAPDLVAEHGGLARKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JTZ6</accession>
    <name>A0A2M9JTZ6_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CG723_17855</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CB01635</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="NNBL01000005">
        <property type="protein sequence ID" value="PJN10257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN10257">
        <property type="protein sequence ID" value="PJN10257"/>
        <property type="gene ID" value="CG723_17855"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="8">
        <location>
            <begin position="26"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="302"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="369"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="316"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="371"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="54"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PJN10257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="534" mass="56531" checksum="11C45732C2D9C369" modified="2018-04-25" version="1">MTSDRRGAPPSFEALSADDPHEIGGYRLSARLGSGGMGHVYLAFTPGGRPVALKAVRPELAGDAAFRHRFAQEVTNTQRVHGLYTAPVIDSGTDAATPWLATAYVPGPSLHEVVQRHGPLPVPTVLLLMAGIAEALQAIHAAGVVHRDLKPANVLLAPDGPRVIDFGIARAADAVALTSAGLQIGTPAFMAPEQALGRPATDATDVFALGALAVYAVCGAPPFGSGPESAALYRVVHEQPDLTHVPPELQNLLWQCLAKSPEERPTAGALIEAVRHHPATGAQLRFTDGWLPHSIRADIARRSDLPGPLQPPHAQPTMTATPTAPARTETAVTASPAPPSAPRGRRRRRRWIVPTATVAVLVAGATAYRLSDSNGDPSKANGPSGRDRSSAPPSRPHSSPPSKSTASPGAGYQQVYADTELTSPDPSYEFDLRNGTVAPESTAAWYLARTADEFDFPDDSDAYIAYDDTLSPGGCEEGIDSEPVTTLKFDDLEEWRPFCIRSANGKDIAIVHLIDAPTASESVTVSVRHYRRTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JUM3</accession>
    <name>A0A2M9JUM3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Proline-specific permease ProY</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">proY</name>
        <name evidence="10" type="ORF">CG723_15340</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CB01635</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the amino acid-polyamine-organocation (APC) superfamily. Amino acid transporter (AAT) (TC 2.A.3.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000004">
        <property type="protein sequence ID" value="PJN10591.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN10591">
        <property type="protein sequence ID" value="PJN10591"/>
        <property type="gene ID" value="CG723_15340"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006865">
        <property type="term" value="P:amino acid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004841">
        <property type="entry name" value="AA-permease/SLC12A_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004840">
        <property type="entry name" value="Amoino_acid_permease_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00324">
        <property type="entry name" value="AA_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00218">
        <property type="entry name" value="AMINO_ACID_PERMEASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="39"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="64"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="103"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="146"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="179"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="218"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="261"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="300"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="352"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="378"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="423"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="449"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="domain" description="AA_permease" evidence="9">
        <location>
            <begin position="37"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PJN10591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="491" mass="52886" checksum="92A1D2FCC8B78102" modified="2018-04-25" version="1">MTSVQVGKQHDGNEAVQAPGESGEGEGYQRGLGARQIQMIAIGGAIGTGLFLGAGKGISKAGPSLILAYAIAGLVIFFIMRALGELLMYRPVSGSFSEYAREFIGPFAGFVTGWTYWLFWVVTGITEVTAAAQYMKYWTHDSVPQWLTALVFTLILYAVNLISVKLFGELEFWFSMVKVTAIVGMILICAGILTVGFSDAGDTASVTHLWSDGGFFPNGIGSTLMTLQMVMFAFLAVELVGVTAGESKDPKTVLPKAINTVPWRIAVFYVGALIMILSVVPWTSFQPGVSPFVAAFEKMGLGVGAAIVNFVVLTAALSSCNSGMYSTGRMLRDLALNGQGPKLFTKLTKSGTPLIGTTVSAAMMLVGVWINYQWPGEAFNYVVSFATISGMWAWIVILICQIRYRIKADRGELPQSSFKAPGGIIPSILSLAFIAMVIVFMGIDKDARVSLYCAPLWAVILGISYVVLRSRNPQSAAFAKRKQPEQSKQPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JV61</accession>
    <name>A0A2M9JV61_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Long-chain fatty acid--CoA ligase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_16335</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000004">
        <property type="protein sequence ID" value="PJN10754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN10754">
        <property type="protein sequence ID" value="PJN10754"/>
        <property type="gene ID" value="CG723_16335"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-binding" evidence="2">
        <location>
            <begin position="56"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN10754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="652" mass="70104" checksum="3FCC542CCF9A6D9E" modified="2018-04-25" version="1">MGVRKDLQRAQQRSDLTDRTTVETVKDEHGTVREVRTAALAADPGGSTPADIPFTNAAETPDVVVLRRREGEHWRPVTAAAFAREVTAAAKGLIAGGLEPGGRVALMSRTRYEWTVLDFAIWAAGGQTVPVYATSSAEQIEWIVRDSGARHLITETPENTATARAALAALPEEEQPRCWELDAGAVLELATLGREMDDEEVTERRAALTPGTVATVCYTSGTTGKPKGCVLTHANLHAEAANTVELLHPIFKEVTGQVASTLLFLPLAHILGRTIQISCMLARIELGHCPGIKSDELRPQLRSFRPTFVVGVPYLFEKIHDTGRATAEKLGRGASFDRADRIAVNYGEAHMARFLNRGKGPDGMGPDGKGGPSLGLRLARGLYDLLVFRRVRKELGGRLRYAISGGSPLDRRLNLFFYAAGILIYEGYGLTETSAAATITPPLAPRPGTVGLPVPGTAVRIADDGEVLVKGGIVFGAYRNNPAATGEVLDGGWFATGDLGALDEDGYLTITGRKKDIIVTSGGKNVSPAVLEDRLRSRPPVGQCIVVGDNRSYVGALITLEPEAVAHWLSVRKMPADTPMADVVRDPRMIAAVQEAVDYANEAVSRAESIRRFALVAGEFTEDNGLLTPSLKIKRHAVAAAYEREIEALYRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-09-29" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JVK0</accession>
    <name>A0A2M9JVK0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CG723_17145</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000004">
        <property type="protein sequence ID" value="PJN10890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN10890">
        <property type="protein sequence ID" value="PJN10890"/>
        <property type="gene ID" value="CG723_17145"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030234">
        <property type="term" value="F:enzyme regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006808">
        <property type="term" value="P:regulation of nitrogen utilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002187">
        <property type="entry name" value="N-reg_PII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011322">
        <property type="entry name" value="N-reg_PII-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015867">
        <property type="entry name" value="N-reg_PII/ATP_PRibTrfase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002332">
        <property type="entry name" value="N-reg_PII_urydylation_site"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30115">
        <property type="entry name" value="PTHR30115"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00543">
        <property type="entry name" value="P-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039144">
        <property type="entry name" value="GlnB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00340">
        <property type="entry name" value="PIIGLNB"/>
    </dbReference>
    <dbReference type="SMART" id="SM00938">
        <property type="entry name" value="P-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54913">
        <property type="entry name" value="SSF54913"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51343">
        <property type="entry name" value="PII_GLNB_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00496">
        <property type="entry name" value="PII_GLNB_UMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="modified residue" description="O-UMP-tyrosine" evidence="2">
        <location>
            <position position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR039144-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR602187-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PJN10890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="112" mass="12223" checksum="8CCE709E450F24C7" modified="2018-04-25" version="1">MKLVTAIVKPFRLDEVKTALQELGVQGLTVTEASGYGRQRGHTEVYRGAEYRIDLVPKVRIEVVVEDADLDPVIDAIVRAAQTGKIGDGKVWAVPVETVVRVRTGERGPDAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JVM5</accession>
    <name>A0A2M9JVM5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_16380</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000004">
        <property type="protein sequence ID" value="PJN10946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN10946">
        <property type="protein sequence ID" value="PJN10946"/>
        <property type="gene ID" value="CG723_16380"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005662">
        <property type="entry name" value="GTP-bd_Era"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42698">
        <property type="entry name" value="PTHR42698"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="G" evidence="1">
        <location>
            <begin position="64"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN10946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="538" mass="57621" checksum="D5010E92793E01BB" modified="2018-04-25" version="1">MPDSYAHEDGLQGADAALVERLDALRELVGLSRARVDGAALAEAGHVLDEAAARRRLSVRHTVVAIAGATGSGKSTLFNALAGVPLSETGLRRPTTSAPIACSWTDGAAGLLDRLGIPGRLRRRPLQGQGPKDADAPLKGLVLVDLPDHDSAAVEHRQQVDRILALVDAVIWVVDPEKYADAMLHERYLRPLAGHAEVTFVVLNQVDRLPGEAADLVLDDLRRLLDEDGIALGEHGEPGATVLSLSALTGDGVDELRESLDQFTREQGAAARRIAADIDAAALRLRPVYATGRKSGLSEDAREEFTDRLADAVGAEAAGQAAERAWRRNANKACGTPWLRLWRWYESQRSPSDTLTVRPLPADDEATARQRVEHAVRIVGERASAGLPGPWGQAVREAATRGAEGLPEALDDLAVSAGSPPPRLPRPGWWPVAVLAQVSMTIIQVIGGLWLLGQIIGVLDPNLGVPVLLMLCGIIGGPCVEWSCRMAAKGPARRYGLDAERRLREAAAGCGRARVLDPVAAELLRYREVREQYVKVTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JVT1</accession>
    <name>A0A2M9JVT1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CG723_08185</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN10980.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN10980">
        <property type="protein sequence ID" value="PJN10980"/>
        <property type="gene ID" value="CG723_08185"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PJN10980.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="96" mass="10272" checksum="F9909E9168F566E9" modified="2018-04-25" version="1">MPGRAMQGSQLARHMTALGIPVKAARNTAVMALAAELPAVAFRRLLGMHIDGAIQWSRMAGAHQNAYAAELSRRWPECGRAERRIALGSVLGEGPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JW05</accession>
    <name>A0A2M9JW05_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cupin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_08785</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN11060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN11060">
        <property type="protein sequence ID" value="PJN11060"/>
        <property type="gene ID" value="CG723_08785"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013096">
        <property type="entry name" value="Cupin_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07883">
        <property type="entry name" value="Cupin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cupin_2" evidence="1">
        <location>
            <begin position="45"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN11060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="165" mass="17878" checksum="3842295926A16F6E" modified="2018-04-25" version="1">MNAQTAPKALLTRAATAETTADPSSVMTLLADYGTDGSALTSYRSTFAKGAVGAPAHFHTKASELFFVLDGALRVLIDDEVKVLEKGDFLMVPPHTPHAFAAAPGREADVLFVFSPGMPRFDYLRLLGRVMRGEAGFEEIKDSSELYDNHYVDSPVWQAALQDAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JW51</accession>
    <name>A0A2M9JW51_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CG723_09125</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN11116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN11116">
        <property type="protein sequence ID" value="PJN11116"/>
        <property type="gene ID" value="CG723_09125"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PJN11116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="186" mass="20099" checksum="CEF02CA5C12719D3" modified="2018-04-25" version="1">MPASPAPADQAIVLLRKLGAADIAHPGGTLVAHLQRVQGQLAVWGARPALQVAGLCHAFYGTDGFPTALLSLDSRAELAEVIGAEAEAIVYLYASCDRRATYPTLMDAEGAFRDRFTGRLHAPEPHLRRDFAELSAANELDLARIDSVFREKWGAGLLALFTRFRPLLSHPAWSDCRTVLAAAPQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JW69</accession>
    <name>A0A2M9JW69_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CG723_09255</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN11136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN11136">
        <property type="protein sequence ID" value="PJN11136"/>
        <property type="gene ID" value="CG723_09255"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PJN11136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="126" mass="13932" checksum="041F709359DF6444" modified="2018-04-25" version="1">MTPHSETAPPVVLYVCADRARGAPGAATQCAQTEGQAFAQERGLAIAEVVTDTYGEPDPARRRGWRRVRQLAQTGHVTAVLVRWPSAIAPESAHELRHRETAWLHDHGVRVQYTWAPLSSRSDEAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JX52</accession>
    <name>A0A2M9JX52_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GNAT family N-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_11230</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN11469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN11469">
        <property type="protein sequence ID" value="PJN11469"/>
        <property type="gene ID" value="CG723_11230"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN11469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="160" mass="17807" checksum="A33A717D8E3EBA46" modified="2018-04-25" version="1">MFIRAFSQRDLASLTELTIETFRPFYEDSFRPLTGDVIFAIQHGSWRDDYRKQVAELHAPERHAYVAVAEAEDGIAGYVAWSVEPVGRKGSVTILAVSAKHRRHRVGTALCEHAFAQMRALGAGLVEIGTGGDPFHAPARALYEQLGCTPFPAMVYFRQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-09-29" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JXD0</accession>
    <name>A0A2M9JXD0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">EstA family serine hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_11570</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN11533.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN11533">
        <property type="protein sequence ID" value="PJN11533"/>
        <property type="gene ID" value="CG723_11570"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001466">
        <property type="entry name" value="Beta-lactam-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00144">
        <property type="entry name" value="Beta-lactamase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Beta-lactamase" evidence="1">
        <location>
            <begin position="23"/>
            <end position="380"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN11533.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="389" mass="41000" checksum="BCDAC2996493ACB6" modified="2018-04-25" version="1">MTQHAPGIQGHCDARFDAVRGAFEENFDERGELGAAFTVLIDGAPVVDLWGGWADAARTRAWERDTVVNVWSTTKGPTALCAHILIDRGLLDPDAPVAAYWPEFAAAGKDGVLVRHLLSHRAGLAGLREPHSLEQLFDWELTTSRLAAQEPWWEPGTVSGYHALTYGFLVGEVVRRVSGLLPGAFLEREVTGPLGIDFTIGLPDKESGRAAEMVHPRAQADSEQAAIFAQLAPAALAALTNPIAGASEANTAAWRAAEIPAANGHGTARAVAALYGIIAGKGRSGDHRILSPEAAERIREGQGSCRDLVLGAGFTHETELGLGLWLSGPNGSYGPNPRAVGHDGFGGSFGSADPESGVALGYVMNRMGPHIADDPRKMALISAVYDALG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JXT0</accession>
    <name>A0A2M9JXT0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CG723_11905</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN11587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN11587">
        <property type="protein sequence ID" value="PJN11587"/>
        <property type="gene ID" value="CG723_11905"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025444">
        <property type="entry name" value="Monooxy_af470"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13826">
        <property type="entry name" value="DUF4188"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PJN11587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="159" mass="18065" checksum="AA493052AD4C96D5" modified="2018-04-25" version="1">MGTKTHAGRMTAGAQGDVVVFLIGMRINHFWAVHRWLPVFIAMPMMIKELNRDRSLGLLHHILLTGSPRTYMVVQYWESKEKLLAYAAAPDKRHHPWWARINRYARKGATHVGIWHETYVVPEGSYETIYGDMPAQGLAKAFGVAGLEDGVQAQDRLRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JY49</accession>
    <name>A0A2M9JY49_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Peptide ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CG723_13250</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CB01635</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN11806.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN11806">
        <property type="protein sequence ID" value="PJN11806"/>
        <property type="gene ID" value="CG723_13250"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025966">
        <property type="entry name" value="OppC_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12911">
        <property type="entry name" value="OppC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="41"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="126"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="162"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="192"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="246"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="304"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="120"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PJN11806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="338" mass="36169" checksum="93653017E576C157" modified="2018-04-25" version="1">MATLPSPESEAAPTEREPTAEIATARSLLGTAWLRIRRSRIAVAALIVVALMVLFAILAPVLVAIEGSDPFSARTGPEFLDDFDTPGLPLSYYRFPSGDHWLGLEPGLGRDIFARMAYGARISLTIALLSTVVSVVLGTVLGAAAGYFGGKVDMVISRVMDLFLAFPHLLLVLSLTPILQSRLRGTSLDSGSLVPIASLVIILGFFGWAYLARVVRGQVLSIRQQEFVEAAQAYGASHRSIIFRQIIPNVMGVVLVYATMMIPTNITAEAALSFLGVGVKDPTPSWGQMLNAAQSGNWYLSDPWFLAVPAGALVITVLAFNLLGDAVRDALDPKSSRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JYI9</accession>
    <name>A0A2M9JYI9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF4440 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_14080</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN11942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN11942">
        <property type="protein sequence ID" value="PJN11942"/>
        <property type="gene ID" value="CG723_14080"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037401">
        <property type="entry name" value="SnoaL-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13474">
        <property type="entry name" value="SnoaL_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="SSF54427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SnoaL-like" evidence="1">
        <location>
            <begin position="5"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13474"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN11942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="129" mass="14299" checksum="3C90DE8E0D7DB7B3" modified="2018-04-25" version="1">MTDDVLKAADALVSAFGEGRLDDYFGAFTPDATFVFHTTAERVASTADYRALWNRWVAEDGFRVVRCTSADQLVQPFGDTAVFSHRVETTVATTAGEETFHERETTVFARQDSGRWLAVHEHLSPAPEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-09-29" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JYP7</accession>
    <name>A0A2M9JYP7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Hydrogenase accessory protein HypB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">hypB</name>
        <name evidence="4" type="ORF">CG723_14385</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CB01635</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SIMIBI class G3E GTPase family. HypB/HupM subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN11995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN11995">
        <property type="protein sequence ID" value="PJN11995"/>
        <property type="gene ID" value="CG723_14385"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016151">
        <property type="term" value="F:nickel cation binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051604">
        <property type="term" value="P:protein maturation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003495">
        <property type="entry name" value="CobW/HypB/UreG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004392">
        <property type="entry name" value="Hyd_mat_HypB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30134">
        <property type="entry name" value="PTHR30134"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02492">
        <property type="entry name" value="cobW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00073">
        <property type="entry name" value="hypB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="cobW" evidence="3">
        <location>
            <begin position="34"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="230"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PJN11995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="249" mass="26714" checksum="4CE72F8BCFFC214B" modified="2018-04-25" version="1">MCRTVDLHQAVLAKNDATAHALRAELAGRGTTMINLLSSPGSGKTALLERELLRARERGVPTAALTADLATENDARRLARSGVPVKQVLTDGLCHLEASMLGRHLEGWLPEATRLLFVENVGNLVCPASYDLGEDLRVVLASVTEGEDKPLKYPTAFGLAHLVVVTKADIAEAVEFDEEAFRAHVEQVNPGVEVVLTSARRGSGVGELLDRALAVADGGAVHEPVMAAQPHEHHHHDHVDDVVMTRPLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JYT5</accession>
    <name>A0A2M9JYT5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CG723_14670</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN12043.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN12043">
        <property type="protein sequence ID" value="PJN12043"/>
        <property type="gene ID" value="CG723_14670"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006059">
        <property type="entry name" value="SBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13416">
        <property type="entry name" value="SBP_bac_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PJN12043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="426" mass="45453" checksum="FCA93728DA37434E" modified="2018-04-25" version="1">MGNDAPSRRTALAALLSAGLATGCSSGARSVASGGTATLRYFFWGDAGRAELINQCIAVFERDHRRIRIKTSFVGFDAYWQKVTTALAGGNPPDLLHVDYAWLRTFASHDLLADLAELTGAGKEIDASAVVPALRTAGLIEGRRVGVPLSRNSIALMYDAGLYAEAGATPPDLKTGWETFAEQTARISKFTKGAQVGVDNPGQNYMGVEMWMMQHGKTAWTEAGQLGFTPDDLHGYLSFIERWRDAGGIAGARVILEAKPGAPITARRAASMFEWDNQVGSRSEARGTRLKLTTPPTDTGTSGLYAKPGMLLSASGATPYRSEAAQFINFMINDRRVAKILGTNIGMAPTTRQEGAASTDDPFVRLTQGYEKRIAGVAAATPPAPGVGGSTLNVRLERIAEKLGYGVISVDEAVDLYFDQAKVVLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JYU7</accession>
    <name>A0A2M9JYU7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ROK family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_14570</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN12028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN12028">
        <property type="protein sequence ID" value="PJN12028"/>
        <property type="gene ID" value="CG723_14570"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000600">
        <property type="entry name" value="ROK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18964">
        <property type="entry name" value="PTHR18964"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00480">
        <property type="entry name" value="ROK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="258"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN12028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="303" mass="31544" checksum="8F97808C51E72457" modified="2018-04-25" version="1">MIPVLEIGGTHVTAAVVDLPDGRVGRRTHRPLDPHAGAEDILGAIRRCADHLDVPTGTRWGMAVPGPFDYAQGIALFAGVGKFEALYGVDVRTALLRELRQRPDDVVFLNDAHAFMMGEWSAGAARGHSRAVGITLGTGVGSAFLVDGGIVARGPGVPPEGRMDLTEADGAPLEESVSRRAILARFGDPSADVRDIADLARAGQRRARRVLDDAFMTLGAVLGPRLTAFGATTLIVGGSMAGSWDLVAPALHAGLADGGWTPDATDPDDGPERPRRHTRSVQPAGLAGDAALIGAARAVAVRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JYY9</accession>
    <name>A0A2M9JYY9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_08665</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN12095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN12095">
        <property type="protein sequence ID" value="PJN12095"/>
        <property type="gene ID" value="CG723_08665"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="144"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="177"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="208"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="246"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="333"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="384"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="429"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="459"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="502"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="553"/>
            <end position="588"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN12095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="594" mass="63404" checksum="EAA63B52ED4A0D8D" modified="2018-04-25" version="1">MYEEPHFPVPRLGAGLQRLGEYQGSGSTERKYLVRREDGQVVQLSRLLYLVVEAIDGVRDTESMSHRVSGRFGREISADNIHYLVEHKLEPLGLTVPFEQADEQVATGPRSDLLLVLKGHRVIFRERQVARIATALAWLHRPSVVALVLAAVTVLDVWLFGYHGAMQPVLQVLEQPVLMLAVFALIVASLVFHEFGHASACRYGGARPGSIGFGLFLIWPSMYTDVTDVYRINRAGRIRTDLGGVYFNVVFVLGLAGAYLLTGQPFFLGAVYLVHFEILEQLMPAVRLDGYYILGDLAGIPDLYGKIKPILLSMLPGRPVTPEVAGLKRSARVIVTIWVLTMVPLIIGELGYVLWNLPRLLATGLRSLAEQATGTWFAFADGEIAAGLVGVVGGFMILCPLAGAGYLTVRLTGRLVRATLRATKGNLRLRLVICAGVLAAGTALGAAWLGGMTPKPLPPQPPIVPILQPGVPTLRATASPSDSDEAPQDDARPDSPLLTGPSPEASLLSPTPDASPSDEADTASGSPSAEDATKTAAPTPKKATSSPTPSRRQSPAPSGPSPSAGTPSVSPSAPPSTSPSPPLPTESFPDPFTW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JZ14</accession>
    <name>A0A2M9JZ14_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Sugar kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_09410</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ROK (NagC/XylR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN12114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN12114">
        <property type="protein sequence ID" value="PJN12114"/>
        <property type="gene ID" value="CG723_09410"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000600">
        <property type="entry name" value="ROK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18964">
        <property type="entry name" value="PTHR18964"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00480">
        <property type="entry name" value="ROK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01125">
        <property type="entry name" value="ROK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN12114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="368" mass="38066" checksum="640713492B27C2BD" modified="2018-04-25" version="1">MFTTVLTRGPVVRPEIARITGLSSAAVTKAVKPMIEAGYLEELPQGPRTVEGAGRPAHPLAVRADREFFVGVKVTADELIGVVTDLRAQVRAAHRIPVTDRSVEQVVRGIAALVAELTPAHAERTHHIGVSVSGDVDRTGGVVRYSPFLGWRDVPLADLVRAATGLAVTVENDVKALTVAEQWFGEGVGADSFALATVGVGIGCALVVNGRLVAGGYGVAGEIGHIPVAAGDGPDCHCGARGCVEAIASEEAIVARARRATGEPDLDMAGAIDRAHGGDAAVRAVFDEAGEAIGLGLAAMVNLVGPERVVVSGEGVAAYDLFEEQIRAAFTTQAFGTAARCPLVVRPLPWEEWARGAAAVSIQSLFAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JZB7</accession>
    <name>A0A2M9JZB7_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 5">Adenine deaminase</fullName>
            <shortName evidence="5">Adenase</shortName>
            <shortName evidence="5">Adenine aminase</shortName>
            <ecNumber evidence="3 5">3.5.4.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">ade</name>
        <name evidence="8" type="ORF">CG723_13465</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CB01635</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 5">
            <text>adenine + H(+) + H2O = hypoxanthine + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:23688"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16708"/>
            <dbReference type="ChEBI" id="CHEBI:17368"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="EC" id="3.5.4.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.2" evidence="3 5"/>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN12210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN12210">
        <property type="protein sequence ID" value="PJN12210"/>
        <property type="gene ID" value="CG723_13465"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000034">
        <property type="term" value="F:adenine deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006146">
        <property type="term" value="P:adenine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01518">
        <property type="entry name" value="Adenine_deamin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006679">
        <property type="entry name" value="Adenine_deam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026912">
        <property type="entry name" value="Adenine_deam_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11113:SF2">
        <property type="entry name" value="PTHR11113:SF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13382">
        <property type="entry name" value="Adenine_deam_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01979">
        <property type="entry name" value="Amidohydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="SSF51338"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0464">Manganese</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydro-rel" evidence="6">
        <location>
            <begin position="57"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="domain" description="Adenine_deam_C" evidence="7">
        <location>
            <begin position="394"/>
            <end position="559"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01518"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF13382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PJN12210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="569" mass="59782" checksum="D0837F95698A1279" modified="2018-04-25" version="1">MSEQHDLRIFGGSVVSTFTGEEFPADVLVRGSAISAVLPPGTPAEAREEIDATGMRIVPGFVDAHMHIESAFLTPQQFAAVTLARGTTTVLADPHEIVNVAGRDAMRWMIDAGDRTPQTQLWGVPSCVPALEGLEHAGAALSADDIAEMLRWPGVVALGEVMDYRAVVAGDPRMAAVTAAARAQGTILDGHCPNLSGAELSAYLATGVDSDHTKNRTEVVLEKARLGMTMMLQEKCLDEDVAKALLDLPQLPPLCLVTDDLAADHIVTKGHLDHIARVAVAAGFPPHVVLRALTWTPAQRLRLYDRGVVSPGKRADLVLLRGELAAFDPAVVLAGGQVVGRDGAAVYEARSGEAGALESRVDVEAQDAEGFRWRVDLPDGTHRFRAMRVNPRDTYTEAAEVELPVSGGEVAWEGRAVLVRVRNRHGRDGVVFAPLLGRDLASGAVATTYAHDSHNLLTIGTSRAAMAAASATVVADGGGVAVVRGTAGESVAARMPLPVGGVLSAEPAARVAEEAGAVRAALEAWGWEHLNPFMSVSTLTLAVSPALKITDRSLVDVARRAPVGATVGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JZE1</accession>
    <name>A0A2M9JZE1_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PPM-type phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_14615</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN12234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN12234">
        <property type="protein sequence ID" value="PJN12234"/>
        <property type="gene ID" value="CG723_14615"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07228">
        <property type="entry name" value="SpoIIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00331">
        <property type="entry name" value="PP2C_SIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="SSF81606"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPM-type phosphatase" evidence="1">
        <location>
            <begin position="225"/>
            <end position="452"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN12234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="596" mass="63862" checksum="24CDBB693B771A97" modified="2018-04-25" version="1">MGGGREHGDSEEYDAEVRQLATLNRLAGPTAAGSAKASERTRHRGADLLVTGHALARAASLGEALTLISQLADATLPLCGQAVFRSDREVLKCVGQVGFRDGEVDALRLPLGTIHPAAQVARTGRPVFLASPQEYRDRFPSAWELAGQQGYEAWAFLPLTTYSQLTSVWMAAFDAPVPMTGGLGTFLLTVARLLGQSIEQSYDGQADRALSQGLRSSMSRIAPGVDGLTVAGRYVPTGGGLMVGGDWFDSILLPGGRLGVVIGDVQGHDVQAAGLMSQLRTAIHAYAAEGHGPDAVLVRASRFLTSLGEGRFATCIYLEADPATGVLRIARAGHPHPVLRLPDGTCLLKHVRGGLPLGLDLGEDDYPVSVVSLRENEILMLCTDGLIESGGHDMYSGWLRVRDALTPGGPEDLDGLADRLLNAVVAPSPAEAGDQPGASFTEDDIALLLLRRDPSDVHANRAGRHLRFTLEQDQAQGLADARIEFQGLLHDWARPEQVDTVLLLVSELLGNVLIHTDHAAVLRAEISGVVPGRRRLRVEVTDRSDEVPNRRAPGELSSSGRGLVLLDLLAHRWNIRPEPEGKTVWFELDEEGPEEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-09-29" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JZR6</accession>
    <name>A0A2M9JZR6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DNA-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_04060</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000002">
        <property type="protein sequence ID" value="PJN12247.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN12247">
        <property type="protein sequence ID" value="PJN12247"/>
        <property type="gene ID" value="CG723_04060"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041413">
        <property type="entry name" value="MLTR_LBD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17765">
        <property type="entry name" value="MLTR_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MLTR_LBD" evidence="2">
        <location>
            <begin position="158"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF17765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN12247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="332" mass="37253" checksum="419C5E97C5D3F8F1" modified="2018-04-25" version="1">MTTMARDTTTTVAEGRARAEAEAPAQAEAQAQAQAKAGGRPGQVAPPLESPKRESEIRRHELADFLRSRRARITPEQVGLPRGRRRRTPGLRREEIAQLSAVGVTWYTWLEQARDIQVSVQVLDALARTLLLDASERAHLFQLAGAVDPSPAASCQTVTPALRLMLEKLEPLPACIQNSRYDILAYNRTYGRLLCDLDTVAPEDRNCMVLICTNEQWRKSFVFLEDTIRLMAAKFRGSMAGHLGEPAWELLLKRLEDESPEFREAWQLHEVVGTRSKTKYFRNAYVGPLSLVHTDLWLGPDQGARLVTYTPADEESRERLDRLQELALAAAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K0E4</accession>
    <name>A0A2M9K0E4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Thiamine biosynthesis protein ThiS</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">thiS</name>
        <name evidence="1" type="ORF">CG723_06100</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000002">
        <property type="protein sequence ID" value="PJN12602.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN12602">
        <property type="protein sequence ID" value="PJN12602"/>
        <property type="gene ID" value="CG723_06100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016155">
        <property type="entry name" value="Mopterin_synth/thiamin_S_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010035">
        <property type="entry name" value="Thi_S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003749">
        <property type="entry name" value="ThiS/MoaD-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34472">
        <property type="entry name" value="PTHR34472"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02597">
        <property type="entry name" value="ThiS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54285">
        <property type="entry name" value="SSF54285"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01683">
        <property type="entry name" value="thiS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PJN12602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="71" mass="7058" checksum="588D10A25E416D55" modified="2018-04-25" version="1">MTVSVTHVSVNGEGRQVAPGTTLDALVSALTTAPSGVAAALNETVVPRAQWAATALTDGDRVEVLTAVQGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K103</accession>
    <name>A0A2M9K103_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CG723_07310</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000002">
        <property type="protein sequence ID" value="PJN12812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN12812">
        <property type="protein sequence ID" value="PJN12812"/>
        <property type="gene ID" value="CG723_07310"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="7"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="38"/>
            <end position="45"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PJN12812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="307" mass="32905" checksum="9E07F2E93EED2D4E" modified="2018-04-25" version="1">MRSEPVVRIQSLVKRYGTRTAVDGLDLEASAGITAVLGPNGAGKTTTIETCEGYRRPDAGTVRVLGLDPVAQAGELRPRIGVMLQSGGVYSGARADEMLRHTAKLHAHPLDVDALIERLGLGSCGRTTYRRLSGGQQQRLALAMAVVGRPELVFLDEPTAGLDPQARRATWDLVRDLRADGVSVILTTHHMDEAEELSDDIAIIDAGRVIAQGSPEQLCRGGAENTLRFSGRPGLDVASLLKALPMDSAAAELTPGSYRVSGEVDPQLLATVTSWCAQHGVMPEKISVERHTLEDVFLEMTGRELRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K195</accession>
    <name>A0A2M9K195_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 4">Triosephosphate isomerase</fullName>
            <shortName evidence="3">TIM</shortName>
            <shortName evidence="3">TPI</shortName>
            <ecNumber evidence="3 4">5.3.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Triose-phosphate isomerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">tpiA</name>
        <name evidence="5" type="ORF">CG723_07235</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CB01635</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3 4">
            <text>D-glyceraldehyde 3-phosphate = dihydroxyacetone phosphate</text>
            <dbReference type="Rhea" id="RHEA:18585"/>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="5.3.1.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 4">Carbohydrate biosynthesis; gluconeogenesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 4">Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate from glycerone phosphate: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 4">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3 4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 4">Belongs to the triosephosphate isomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.1" evidence="3 4"/>
    <dbReference type="EMBL" id="NNBL01000002">
        <property type="protein sequence ID" value="PJN12797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN12797">
        <property type="protein sequence ID" value="PJN12797"/>
        <property type="gene ID" value="CG723_07235"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00189"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00138"/>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004807">
        <property type="term" value="F:triose-phosphate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00311">
        <property type="entry name" value="TIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00147_B">
        <property type="entry name" value="TIM_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035990">
        <property type="entry name" value="TIM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022896">
        <property type="entry name" value="TrioseP_Isoase_bac/euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000652">
        <property type="entry name" value="Triosephosphate_isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020861">
        <property type="entry name" value="Triosephosphate_isomerase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21139">
        <property type="entry name" value="PTHR21139"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00121">
        <property type="entry name" value="TIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51351">
        <property type="entry name" value="SSF51351"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00419">
        <property type="entry name" value="tim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00171">
        <property type="entry name" value="TIM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51440">
        <property type="entry name" value="TIM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 3 4" id="KW-0312">Gluconeogenesis</keyword>
    <keyword evidence="3 4" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="2 3 4" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="3">
        <location>
            <begin position="11"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="3">
        <location>
            <begin position="240"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="active site" description="Electrophile" evidence="3">
        <location>
            <position position="101"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="3">
        <location>
            <position position="173"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="179"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="219"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PJN12797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="258" mass="27857" checksum="A08FAC1203014493" modified="2018-04-25" version="1">MTTRTPLMAGNWKMNLNHLEAIAHVQKLAFALSDKDYDAVEVAVLPPFTDLRSVQTLVDGDKLKIKYGAQDISAHDSGAYTGEISGPMLAKLKCTFVAVGHSERRQYHNETDEVCNAKVKAAFKHGLTPILCVGEELHVREAGDHVAHTLSQVEGGLKDIPAEQAETIVIAYEPVWAIGTGKVCGAEEAQEVCGAIRGKLAELYSQELADKVRIQYGGSVKSGNVAEIMSKPDVDGALVGGAALDAEEFVKIIRFRDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-09-29" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K1Q1</accession>
    <name>A0A2M9K1Q1_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">MFS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CG723_00100</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CB01635</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000001">
        <property type="protein sequence ID" value="PJN13048.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN13048">
        <property type="protein sequence ID" value="PJN13048"/>
        <property type="gene ID" value="CG723_00100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="46"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="72"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="99"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="130"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="162"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="210"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="252"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="289"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="322"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="351"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="389"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="7"/>
            <end position="412"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PJN13048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="436" mass="45603" checksum="FD03EEC7DA4BEF5C" modified="2018-04-25" version="1">MSRAWRTTWLLLAFMLVNFADKAVLGLAGPEIRADFGITRQEFGTAQSAFFTLFSLAALGVSALTRRVRTTTLLLVLALLWSVAQLPMLWGAAGFGTLLATRVLLGAAEGPASPVAMHHVHGWFPQRERALPTAVLLVGAAAGVAVASPVLTWVITHWGWRWSFGVVGMAGLLWAVCWRLWGTDGPLAPSVTKKHSEAAERTPTTDTVPLRAILISGTFLTAAFGSFAAYWSMSTMLTWAPDYLESVVGWDLHQAGTMVGLGALASGAVILGHGLIAQRSARKGTPRRLPPGAGAGLLVTVAGCATAVYGTTDSLAVKVPMMLGPMALAMVMLTVASTACARIAPPAQRGVVLGTLTFVYALGGILSPLVLGGMVDRARTVSAGYEEGWLLTAGLLVTAGVLAALFCRPETTARRLGLPEPAAGSVPQVPVVPVVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K241</accession>
    <name>A0A2M9K241_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_00945</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000001">
        <property type="protein sequence ID" value="PJN13191.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN13191">
        <property type="protein sequence ID" value="PJN13191"/>
        <property type="gene ID" value="CG723_00945"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="44"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN13191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="65" mass="6827" checksum="DD3AB2F9499849A4" modified="2018-04-25" version="1">MSQEAMSEQVVHEPAGPDQEGAPKGLLQQMEELMAALNADLSQLDADLQQSTGPGAPSADEGHRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-09-29" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K284</accession>
    <name>A0A2M9K284_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Tat pathway signal sequence domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CG723_01240</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000001">
        <property type="protein sequence ID" value="PJN13244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN13244">
        <property type="protein sequence ID" value="PJN13244"/>
        <property type="gene ID" value="CG723_01240"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025419">
        <property type="entry name" value="DUF4142"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012347">
        <property type="entry name" value="Ferritin-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13628">
        <property type="entry name" value="DUF4142"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014696123" evidence="2">
        <location>
            <begin position="32"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4142" evidence="3">
        <location>
            <begin position="57"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="201"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="211"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13628"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PJN13244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="247" mass="26422" checksum="A63F7129D3F14CC5" modified="2018-04-25" version="1">MRTRFVNGTGLIVAGLVTTLAALVFPVWSYADRSGTGVDLLDEGTVSTRFGPLSALDREFVTKVRLAGLWELPAGQQAEARGTSTAVRTAGEHLVEGHTFLDARVREVAARLGLELPNQPGSQQQHWLSELSAAHGEDYERKFANILRRAHGKVFSLVAQVRATTRNSLVRDLADDANKTVLDHIKILESTGLVDFDALARDAAGTSTPPETRSPAPPGPVTSPEPPTPLSPSPSFPLPPAASRPKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-05-25" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K2K9</accession>
    <name>A0A2M9K2K9_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Sulfate adenylyltransferase</fullName>
            <ecNumber evidence="1">2.7.7.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CG723_01650</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.4" evidence="1"/>
    <dbReference type="EMBL" id="NNBL01000001">
        <property type="protein sequence ID" value="PJN13310.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN13310">
        <property type="protein sequence ID" value="PJN13310"/>
        <property type="gene ID" value="CG723_01650"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004781">
        <property type="term" value="F:sulfate adenylyltransferase (ATP) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006790">
        <property type="term" value="P:sulfur compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04166">
        <property type="entry name" value="CysN_ATPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03695">
        <property type="entry name" value="CysN_NodQ_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04095">
        <property type="entry name" value="CysN_NoDQ_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041757">
        <property type="entry name" value="CysN_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044138">
        <property type="entry name" value="CysN_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044139">
        <property type="entry name" value="CysN_NoDQ_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031157">
        <property type="entry name" value="G_TR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011779">
        <property type="entry name" value="SO4_adenylTrfase_lsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009001">
        <property type="entry name" value="Transl_elong_EF1A/Init_IF2_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="SSF50447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50465">
        <property type="entry name" value="SSF50465"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02034">
        <property type="entry name" value="CysN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00301">
        <property type="entry name" value="G_TR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3 9" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Tr-type G" evidence="8">
        <location>
            <begin position="14"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="432"/>
            <end position="452"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PJN13310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="452" mass="48254" checksum="411C2407A7CC9033" modified="2018-04-25" version="1">MTTTTEQLADLSATTLLRFATAGSVDDGKSTLVGRLLHDSKSVLTDQLEAVEHASRNRGQETPDLALLTDGLRAEREQGITIDVAYRYFATARRRFILADTPGHVQYTRNMVTGASTADLAVVLVDARNGVIEQTRRHAAVAALLRVPHVVLAVNKMDLVDYAEPVFAKIAEEFTAYASDLGVPEITAIPISALAGDNVVEPSANMDWYGGPTVLEHLETVPVSHDLTSCHARLPVQVVIRPQTAEHPDYRGYAGQIAAGTFRVGESVTVLPSGRTSKVSGIDLLGKSVDVAWTPQSVTLLLEDDIDISRGDLIVPSGDAPATSQDVEATVCHVADQPLAVGQRVLLKHTTRTVKAIVKEIPSRLTLDDLSQHPEPGQLVANDIGRVKVRTAEPVALDDYADSRRTGSFLLIDPSDGTTLAAGMAGEAFGGKAHAAHAEETAPASDDDGWDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K2L6</accession>
    <name>A0A2M9K2L6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Tat pathway signal sequence domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_01380</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000001">
        <property type="protein sequence ID" value="PJN13267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN13267">
        <property type="protein sequence ID" value="PJN13267"/>
        <property type="gene ID" value="CG723_01380"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008557">
        <property type="entry name" value="PhoX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05787">
        <property type="entry name" value="DUF839"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014915964" evidence="1">
        <location>
            <begin position="47"/>
            <end position="466"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN13267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="466" mass="49654" checksum="3291F5CD30E59195" modified="2018-04-25" version="1">MSEARTARTAQSPATRRQVLARSGASVAAIAFAGSLSELFAGTAAAQSLGNKGYGPLVPDPAGLLDLPAGFRYKVLSREGDPLRSGEGKVPSNHDGMTALEGRHGRVHLVRNHENRVTAKIAVPTVEGLTYDPMGKGGCTALTLDHRGNVLSERVAIAGTAVNCAGGHTPWGTWLTCEETEDKAGTNGYTKDHGFIFEVDPADPRRSGAVPLTAMGRFQHEAIAIDPKRGVVYETEDAFEKPFGLFYRFLPNKPEGGLGSLRAGGTLQAMRVPGVPDLSVIQETGATFDGIEWVDVPDPLAAQTPIRLQDFGTKGITHAQKLEGCYWGGSSVYFVSSFAHSAEGSAADHFGQIWRYDPSRRRLTLVIVFGPSTDVQLPGEEPDNICLAPSGGLMVCEDGEGAQHVFGVTRKGDVYAMARGRQNIGTAQEPAWGEFAGVTFSPDGDTMYVNCYTPGTTFAVTGPWQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K2P8</accession>
    <name>A0A2M9K2P8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CG723_02110</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000001">
        <property type="protein sequence ID" value="PJN13393.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN13393">
        <property type="protein sequence ID" value="PJN13393"/>
        <property type="gene ID" value="CG723_02110"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PJN13393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="256" mass="27800" checksum="274599C977240184" modified="2018-04-25" version="1">MERRKFAAGIAAAAATPALLGAAPAPSHGDDRLRKAMRAALGAELDDRAAAHAVEPHIHDIGFDWHPPTVPLDRIDFLVAYGFGNRPPAGGGDPTKVMYEPGPVNEELADTVARVRARRDVPVYAQWEIARFLKSKYRMTDVTSIEPVIAPDGTITYLSTDGVAAQVVEARKKLPEGIGTAGVIGFRDHVKRCVQTTNDRGMKAYAPAGFEMPGTYDPESGQAWTRRRDLYLVHDMTAQWTVLREKLIAQAGSGNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K2X0</accession>
    <name>A0A2M9K2X0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">O-acetyl-ADP-ribose deacetylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_02610</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000001">
        <property type="protein sequence ID" value="PJN13476.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN13476">
        <property type="protein sequence ID" value="PJN13476"/>
        <property type="gene ID" value="CG723_02610"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.220.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002589">
        <property type="entry name" value="Macro_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043472">
        <property type="entry name" value="Macro_dom-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01661">
        <property type="entry name" value="Macro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00506">
        <property type="entry name" value="A1pp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52949">
        <property type="entry name" value="SSF52949"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51154">
        <property type="entry name" value="MACRO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Macro" evidence="1">
        <location>
            <begin position="1"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN13476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="171" mass="17812" checksum="039F805776057A97" modified="2018-04-25" version="1">MTRITLVKGDITAETADAIVNAANSSLLGGGGVDGAIHRRGGPEILAECRRLRASHYGKGLATGQAVATTAGNLDAGHVIHTVGPVWSASLDRSELLASCYRESLRVAAGLGARTVAFPAISTGIYGWPLDDGARIAVRTVREVVAPPVEEVRFVLFDDRAYAAFADALAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K339</accession>
    <name>A0A2M9K339_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CG723_02430</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000001">
        <property type="protein sequence ID" value="PJN13447.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN13447">
        <property type="protein sequence ID" value="PJN13447"/>
        <property type="gene ID" value="CG723_02430"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PJN13447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="85" mass="9421" checksum="B87235BE01F38890" modified="2018-04-25" version="1">MARARSTAACSGFGQHIVEKDTKSLAGERDPPLPWSGHTNVPATKRWYVKPDVEDLREASTTWDGLHGVSTQSCEKLRDVRPCRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K358</accession>
    <name>A0A2M9K358_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">LLM class F420-dependent oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_02545</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000001">
        <property type="protein sequence ID" value="PJN13467.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN13467">
        <property type="protein sequence ID" value="PJN13467"/>
        <property type="gene ID" value="CG723_02545"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022315">
        <property type="entry name" value="F420_OxRdatse_CPS4043_pred"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011251">
        <property type="entry name" value="Luciferase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036661">
        <property type="entry name" value="Luciferase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00296">
        <property type="entry name" value="Bac_luciferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51679">
        <property type="entry name" value="SSF51679"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03842">
        <property type="entry name" value="F420_CPS_4043"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bac_luciferase" evidence="1">
        <location>
            <begin position="6"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN13467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="339" mass="37056" checksum="27AABDACE6DF3186" modified="2018-04-25" version="1">MDFGLVLQTDPPASGVVSLMQRAEREGFTHGWTFDSAVLWQEPFVIYSRILAETSHLTVGPMVTNPGTRTWEVTASTFATLNDMYGNRTICGIGRGDSAMRVAGRKPNTLARISEAMKVIRALGRGDEADLGGTVVRFPWVRDGARLPVWMAAYGPKALKMAGEEADGFILQLADPYLTQYMIKAVRDAAAGAGRDPSEVKICVAAPAYVTADDSPEALAHAREECRWFGGMVGNHVADLVTKYGEHSSMVPDELTDYIKARQGYDYAHHGRTGNPDTAFVPDEIVDRFCLIGTAQDQVEKLRALRDLGVDQFALYAMHDAKEEVIDAYGEHVIPAVNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K361</accession>
    <name>A0A2M9K361_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">AP endonuclease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_03110</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000001">
        <property type="protein sequence ID" value="PJN13564.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN13564">
        <property type="protein sequence ID" value="PJN13564"/>
        <property type="gene ID" value="CG723_03110"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036237">
        <property type="entry name" value="Xyl_isomerase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013022">
        <property type="entry name" value="Xyl_isomerase-like_TIM-brl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01261">
        <property type="entry name" value="AP_endonuc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51658">
        <property type="entry name" value="SSF51658"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AP_endonuc_2" evidence="1">
        <location>
            <begin position="22"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN13564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="334" mass="37813" checksum="184266A352EEA4E2" modified="2018-04-25" version="1">MPRQFTLFTGQWADLPLEEVCRLARDFGYDGLELACWGDHFEVDKALADPGYLDSRRALLDKYGLKCWAISNHLVGQAVCDAIIDERHRAILPARIWGDGEAEGVRRRAAAEMEDTARAAAAFGVDTVIGFTGSSIWHLVAMFPPAPEPMIERGYQDFADRWNPILDVFDENGVLFAHEVHPSEIAYDYWTTQRALDAVDHRAAFGLNFDPSHFVWQDLDPVGFLWDFRDRIYHVDCKEARRRLDGRNGRLGSHLPWGDPRRGWDFVSAGHGDVPWEDVFRMLRSIDYEGPVSVEWEDAGMDRLQGAPEALKHLKAFDFEPPTASFDAAFGGSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K3W0</accession>
    <name>A0A2M9K3W0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Lysine transporter LysE</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CG723_02080</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000001">
        <property type="protein sequence ID" value="PJN13760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN13760">
        <property type="protein sequence ID" value="PJN13760"/>
        <property type="gene ID" value="CG723_02080"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006865">
        <property type="term" value="P:amino acid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001123">
        <property type="entry name" value="LeuE-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30086">
        <property type="entry name" value="PTHR30086"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01810">
        <property type="entry name" value="LysE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006324">
        <property type="entry name" value="LeuE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="6"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="41"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="69"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="121"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="154"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="189"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PJN13760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="214" mass="22220" checksum="7CDB4CD325C485F1" modified="2018-04-25" version="1">MVSTDRYLAFAAMSLLVIVIPGPSVLFVIGRALAHGRRTAVATALGNVIGSYVLVVGVALGIGSLVERSAAVFMAVKLAGAAYLVFLGVQAFRHRREMRAEDIRAPQGPPRGDLRTVADGALVGVTNPKGIVFFAAVLPQFVDHSGGQVPVQMLLLGLIPISIGLVTDTLWGLTASAARTWFARSDRRLSLIGGTGGFAMIGLGVTVAATGRAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K451</accession>
    <name>A0A2M9K451_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">SGNH hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_03815</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000001">
        <property type="protein sequence ID" value="PJN13807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN13807">
        <property type="protein sequence ID" value="PJN13807"/>
        <property type="gene ID" value="CG723_03815"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013830">
        <property type="entry name" value="SGNH_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13472">
        <property type="entry name" value="Lipase_GDSL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SGNH_hydro" evidence="1">
        <location>
            <begin position="18"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN13807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="263" mass="28744" checksum="1BDBF9795E33C09A" modified="2018-04-25" version="1">MANESRSLSGGTIRSYAAVGDSFTEGVGDPGPDGAFVGWADRLAVLLDDRTPEHSFRYANLAVRGKLLDQIVEDQLPRAVELAPDLVTFAAGGNDIIRPGTDPDDVAERFEKAVARLTSAVGTVMVTTGFDTRDVPVLKHLRGKIATYNGHVRAVADRYGCPVLDLWSLKTVQDRRAWDGDRLHLSPEGHTRVALRAGQALGVEVPADPDQPWPAQPPRGTLEVRRDDIHWAREFLVPWIGRRLRGESSGDHVAAKRPDLLPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JF37</accession>
    <name>A0A2M9JF37_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Mycofactocin system transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">mftR</name>
        <name evidence="3" type="ORF">CG723_44420</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000047">
        <property type="protein sequence ID" value="PJN05510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN05510">
        <property type="protein sequence ID" value="PJN05510"/>
        <property type="gene ID" value="CG723_44420"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023772">
        <property type="entry name" value="DNA-bd_HTH_TetR-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041347">
        <property type="entry name" value="MftR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023851">
        <property type="entry name" value="Tscrpt_reg_TetR-type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17754">
        <property type="entry name" value="TetR_C_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03968">
        <property type="entry name" value="mycofact_TetR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01081">
        <property type="entry name" value="HTH_TETR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="6"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="29"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN05510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="195" mass="21873" checksum="E851BC19B55D1BBE" modified="2018-04-25" version="1">MGRPRATSRTDLERIGFELFASQGFDSTTVDDIARAAGIGRRTFFRYFGSKNDLVWGDFEDQLAGLRELLEATAPDVPVADALREAVVAFNRFDPEEVPWHRQRMQLILTVPTLQADATLRYNEWRAIVTEFVAARTGLPTSDLLPRLVGYASLSAAIAAYEHWLADERQGLEPLIDATFRQLARGWESTIPCQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JF45</accession>
    <name>A0A2M9JF45_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">GntR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CG723_44400</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000047">
        <property type="protein sequence ID" value="PJN05489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN05489">
        <property type="protein sequence ID" value="PJN05489"/>
        <property type="gene ID" value="CG723_44400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07377">
        <property type="entry name" value="WHTH_GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.530">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000485">
        <property type="entry name" value="AsnC-type_HTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011711">
        <property type="entry name" value="GntR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008920">
        <property type="entry name" value="TF_FadR/GntR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07729">
        <property type="entry name" value="FCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
        <property type="entry name" value="GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00033">
        <property type="entry name" value="HTHASNC"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00035">
        <property type="entry name" value="HTHGNTR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00895">
        <property type="entry name" value="FCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00345">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48008">
        <property type="entry name" value="SSF48008"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50949">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH gntR-type" evidence="5">
        <location>
            <begin position="25"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PJN05489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="234" mass="26396" checksum="23DA4D3BCD5CB092" modified="2018-04-25" version="1">MVGKSSSKPEGSVTAGPASSVSEPMQLTLQAAAQIRGLIIEGVLLPGQKIRQVDLAEQIGVSRSPLREALRTLESEGVVTYETNRGYVVARLEPSDLAEIYRMRELLEGELLRSIVKPDKKTLDALVRYNDEMIAAVGQGDIAAVLRANREFHFTIFELSPLNQFKREIRRLWQLSEGYLAWWWRLPHVTTRISQEHKQIIKALRKYDREALVESFNAHRVSGHESALPLLGRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-09-29" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JFB6</accession>
    <name>A0A2M9JFB6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">(2Fe-2S)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_43960</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000045">
        <property type="protein sequence ID" value="PJN05564.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN05564">
        <property type="protein sequence ID" value="PJN05564"/>
        <property type="gene ID" value="CG723_43960"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002888">
        <property type="entry name" value="2Fe-2S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036884">
        <property type="entry name" value="2Fe-2S-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036010">
        <property type="entry name" value="2Fe-2S_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001041">
        <property type="entry name" value="2Fe-2S_ferredoxin-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006058">
        <property type="entry name" value="2Fe2S_fd_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00111">
        <property type="entry name" value="Fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01799">
        <property type="entry name" value="Fer2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47741">
        <property type="entry name" value="SSF47741"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54292">
        <property type="entry name" value="SSF54292"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00197">
        <property type="entry name" value="2FE2S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51085">
        <property type="entry name" value="2FE2S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="2Fe-2S ferredoxin-type" evidence="2">
        <location>
            <begin position="10"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN05564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="162" mass="17307" checksum="9B881E60824AF3A4" modified="2018-04-25" version="1">MPQNNPSPETAVMLRVNGKKIEVTCDVRATLLDLLRERLRLTGTKKGCNRGECGACTVHLDGRRVNACLVLAASADGAEVTTVEGLARGEQLHPVQEAFIESDAFQCGFCTPGQIMSAVACIQEGHTGSNEEIREWMSGNICRCSAYPQIAAAVASAARDEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JFE2</accession>
    <name>A0A2M9JFE2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_44200</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000046">
        <property type="protein sequence ID" value="PJN05523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN05523">
        <property type="protein sequence ID" value="PJN05523"/>
        <property type="gene ID" value="CG723_44200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046295">
        <property type="entry name" value="DUF6332"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19857">
        <property type="entry name" value="DUF6332"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="39"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN05523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="71" mass="7434" checksum="B125E0B5FA22E1F8" modified="2018-04-25" version="1">MTVEIVFALVTAVALAAAVFTVALTLALAFGISGSAKKSVLVGGALLGATAGMWRLVRVLLRFDEQRRMGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JFL6</accession>
    <name>A0A2M9JFL6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CG723_43300</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000043">
        <property type="protein sequence ID" value="PJN05695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN05695">
        <property type="protein sequence ID" value="PJN05695"/>
        <property type="gene ID" value="CG723_43300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PJN05695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="82" mass="8442" checksum="056D6C3953F0E6AA" modified="2018-04-25" version="1">MGDRKGVAEGVPIAVRLDPQAVTVTGITPGLRIQCEGVPVADWLCVCGQHEHARGRAAVIRLTARVSVGICPHTTAEGSAAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JFM0</accession>
    <name>A0A2M9JFM0_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CG723_43805</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CB01635</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="NNBL01000044">
        <property type="protein sequence ID" value="PJN05622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN05622">
        <property type="protein sequence ID" value="PJN05622"/>
        <property type="gene ID" value="CG723_43805"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="8">
        <location>
            <begin position="11"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="271"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="412"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="40"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PJN05622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="446" mass="48207" checksum="F74AB46557EEB663" modified="2018-04-25" version="1">MERGGRIADRYELVKRLGSGGMGEVWAGRDHDLHRNVALKLLILNQGTHSDLPKRFEREAVAAAQINHPNVAALYERGVQGNVHYIVLEKVEGSSLGDVILHDGRLDPARALAIADGICAALVAAHRAGVVHYDIKPHNVMLTADGQVKVVDFGIAGFNQTPLPLARTTVLAPAGTAEYAAPEQFLAERGDERSDLYALGGVLFAMLTGQPPFTGDGFMEVLQRKLAEDAPRPDTIRPGLPPALTALVTELLDRVPDRRPQTAQQVQTYLSRLQRGPGAPETSDRPPIQDAGPGSTVAISPGGLQSPLVQALASVSGPLEFGAQLRVLRQRADGTWTETRMAHAVFSSEWPLDPNDQARADTIVERWFNGASLPARWAALERLVTALGARDDEVSAVRVAWIRVISSHPDVPLTPDGSLGPTAPRATQPAPQPPSRPRGRVWRWLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JFR5</accession>
    <name>A0A2M9JFR5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CG723_43150</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000042">
        <property type="protein sequence ID" value="PJN05730.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN05730">
        <property type="protein sequence ID" value="PJN05730"/>
        <property type="gene ID" value="CG723_43150"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021441">
        <property type="entry name" value="DUF3090"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11290">
        <property type="entry name" value="DUF3090"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03847">
        <property type="entry name" value="TIGR03847"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PJN05730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="196" mass="21445" checksum="91E0CEA533B5F6FB" modified="2018-04-25" version="1">MSRQVFLYDPPERFVAGTVGLPGRRTFFLQASDGARVTSVALEKTQVAALAERMDELLDEVVRRSGGNAPVPAVVPTEIHDTAPLESPVDEEFRVGTMALAWDGEEERMIVEAQALVELDADTDEDLAEAEERLLQDEENGPPMLRVRLTGVQARAFAKRALDVVNAGRPPCPLCSLPLDPEGHVCPRQNGYRRGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JFU2</accession>
    <name>A0A2M9JFU2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Proteinase inhibitor I78</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CG723_42775</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000041">
        <property type="protein sequence ID" value="PJN05764.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN05764">
        <property type="protein sequence ID" value="PJN05764"/>
        <property type="gene ID" value="CG723_42775"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021719">
        <property type="entry name" value="Prot_inh_I78"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11720">
        <property type="entry name" value="Inhibitor_I78"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PJN05764.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="71" mass="7688" checksum="AEF3262169527EEC" modified="2018-04-25" version="1">MAPIPTPPADPQDTLDTYVGLDAPGAEARARERGWSTVRSLPPGAIITMEYRAGRLNFEVSDGTVTRCWKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JG77</accession>
    <name>A0A2M9JG77_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">UDP-glucose 4-epimerase</fullName>
            <ecNumber evidence="5">5.1.3.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">galE</name>
        <name evidence="9" type="ORF">CG723_42345</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CB01635</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>UDP-alpha-D-glucose = UDP-alpha-D-galactose</text>
            <dbReference type="Rhea" id="RHEA:22168"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="ChEBI" id="CHEBI:66914"/>
            <dbReference type="EC" id="5.1.3.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Carbohydrate metabolism; galactose metabolism.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the NAD(P)-dependent epimerase/dehydratase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.1.3.2" evidence="5"/>
    <dbReference type="EMBL" id="NNBL01000039">
        <property type="protein sequence ID" value="PJN05878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN05878">
        <property type="protein sequence ID" value="PJN05878"/>
        <property type="gene ID" value="CG723_42345"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00214"/>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003978">
        <property type="term" value="F:UDP-glucose 4-epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006012">
        <property type="term" value="P:galactose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005886">
        <property type="entry name" value="UDP_G4E"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01179">
        <property type="entry name" value="galE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0520">NAD</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Epimerase" evidence="8">
        <location>
            <begin position="3"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00018569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PJN05878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="326" mass="34403" checksum="5E641E67AF2F5CA9" modified="2018-04-25" version="1">MTWLITGGAGYIGAHVVRAMQEAGERTVVYDDLSTGVAERVPDGVPLVVASTLDADAVARTIAGHGITGVVHLAAKKQVGESVELPLHYYRENVEGLRVLLAAVTAGGVPSFVFSSSAAVYGMPDVDLVTEDTPCLPMSPYGETKLAGEWLVRATGRAHGLATASLRYFNVAGAAAPELADTGVFNLVPMVFERLTDGEAPRIFGADYPTPDGTCVRDYIHVVDLAEAHVAAARRLSGEAPGTDLTLNIGRGEGVSVLEMVELINATTGHGTDPVVTPRRPGDPARVVASADRIATELGWTAKRDVREMVESAWQGWVRVHGTAVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JH61</accession>
    <name>A0A2M9JH61_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Electron transfer flavoprotein subunit alpha</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CG723_40025</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000033">
        <property type="protein sequence ID" value="PJN06211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN06211">
        <property type="protein sequence ID" value="PJN06211"/>
        <property type="gene ID" value="CG723_40025"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PJN06211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="27" mass="3006" checksum="8F3B2CBA7A1F1953" modified="2018-04-25" version="1" fragment="single">DLVDYGVVGDLFDVVPQLTEEIKTRKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JIF6</accession>
    <name>A0A2M9JIF6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_38235</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000028">
        <property type="protein sequence ID" value="PJN06547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN06547">
        <property type="protein sequence ID" value="PJN06547"/>
        <property type="gene ID" value="CG723_38235"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023346">
        <property type="entry name" value="Lysozyme-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53955">
        <property type="entry name" value="SSF53955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014818973" evidence="2">
        <location>
            <begin position="39"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="91"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="91"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN06547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="243" mass="25760" checksum="C981E7078A0B611D" modified="2018-04-25" version="1">MLEGNRVSRISVRGFAVASATAVTTVGAVVGVASGSTAQPSNNEAEATASDATLLADIPAGQQAQVQTATLTQQAETQAIAADNAAQKSAEEAARKKAAEDAVAKQQAAADAKEKAEKEAKEREEAKKVASRSATRDASSFATQASYSTSQIQAMARQMVPAGQFQCFSNIVDHESSWNYRATNASSGAYGLFQALPASKYSTAGADWQTNPATQIKWGLNYMDSRYGSPCEAWSFWQANHWY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JII1</accession>
    <name>A0A2M9JII1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">TetR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_37860</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000027">
        <property type="protein sequence ID" value="PJN06653.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN06653">
        <property type="protein sequence ID" value="PJN06653"/>
        <property type="gene ID" value="CG723_37860"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004111">
        <property type="entry name" value="Repressor_TetR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02909">
        <property type="entry name" value="TetR_C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="25"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="48"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN06653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="236" mass="25887" checksum="54A7964DC3693598" modified="2018-04-25" version="1">MTGRAAEPEVIWTRPERAGRGPKPAYGRSDIAAVAVRVADADGIDAVSMRRVAAELGLGTMSLYNYVPRKDDLYELMVDAVSAEYDLADPTGDWRADLLGVARQARALMIRHPWMPRLMSPVYGYSPNALRYLEYCMACLAPVDLPAGTKMELVASLTGVVTFYVANEISAAERTRSLPWSQEREFAMRTAYLVSRISTGEYPHLAAAFTQSAGPVDMEAAFERALARTLDGFVPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JIX7</accession>
    <name>A0A2M9JIX7_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">zinc_ribbon_2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CG723_37390</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000026">
        <property type="protein sequence ID" value="PJN06812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN06812">
        <property type="protein sequence ID" value="PJN06812"/>
        <property type="gene ID" value="CG723_37390"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026870">
        <property type="entry name" value="Zinc_ribbon_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13240">
        <property type="entry name" value="zinc_ribbon_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="175"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="256"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="297"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="342"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="396"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="428"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="469"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="domain" description="zinc_ribbon_2" evidence="3">
        <location>
            <begin position="4"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="27"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="514"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="34"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="527"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="589"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PJN06812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="589" mass="58641" checksum="006AC35AA74D48BD" modified="2018-04-25" version="1" fragment="single">MASFCPHCGAQAPDEARFCMKCGRERTPEREPDVQVPSAPPAAPFGQPGQPPVPPLAPPAAPPPPAFAPGGPSPVAAFLGRAFRGDWAGSAQAALWPVGLLVIAAVALAVPSYGQGSDVVVGFGDRMRISLALLLQSLGGGFEVSASSGSSPFGGGDSPFGSGGGGMGAELSGGAALSLVPLTVTALWILALWIGVRVLRSRLRARAAVPDGHPTPVPGTPGLEAALRVALLVTVGVLVLGLFAQPSVQGVRISSSPVLAALGALLISLTVAAGMLHRDDLAQWLAARPGAPALVRAIGTALRALAVVLVICSVAAFIGIAQIDGLGDVSDVSDLGRADLSPLVLALLVLPNLGAMALGLGWGAPISFEAGGSSTYGGGYQHQSFGLSELGDATNAWAVVGALALGAVCALTVGVMAARRSADRREQLLSAGIFLGLFLLLGALGGLGVRATGAASDLGGSGTGSAGVGLGMAEALLFGLLWVFAAAFLAPYLMQMAGARTGIVPEPQVPPGAFGSARGVPAPATAMPEAPAEPPAASEPPAPIDPPSPAVAAALPTSPSTWRPHPRDTAGCIRPTACWCKATTTRQAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JJ37</accession>
    <name>A0A2M9JJ37_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">NADH-quinone oxidoreductase subunit H</fullName>
            <ecNumber evidence="5">7.1.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">NADH dehydrogenase I subunit H</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">NDH-1 subunit H</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">nuoH</name>
        <name evidence="7" type="ORF">CG723_37635</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CB01635</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a quinone + 5 H(+)(in) + NADH = a quinol + 4 H(+)(out) + NAD(+)</text>
            <dbReference type="Rhea" id="RHEA:57888"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="5">NDH-1 is composed of 14 different subunits. Subunits NuoA, H, J, K, L, M, N constitute the membrane sector of the complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5 6">Cell membrane</location>
            <topology evidence="5 6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 6">Belongs to the complex I subunit 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.1.1.-" evidence="5"/>
    <dbReference type="EMBL" id="NNBL01000026">
        <property type="protein sequence ID" value="PJN06797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN06797">
        <property type="protein sequence ID" value="PJN06797"/>
        <property type="gene ID" value="CG723_37635"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016655">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01350">
        <property type="entry name" value="NDH1_NuoH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001694">
        <property type="entry name" value="NADH_UbQ_OxRdtase_su1/FPO"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11432">
        <property type="entry name" value="PTHR11432"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00146">
        <property type="entry name" value="NADHdh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 6" id="KW-0520">NAD</keyword>
    <keyword evidence="5" id="KW-0874">Quinone</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-1278">Translocase</keyword>
    <keyword evidence="2 5 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0830">Ubiquinone</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="79"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="110"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="154"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="182"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="229"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="265"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="298"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PJN06797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="322" mass="34575" checksum="83F3C338E0532FD5" modified="2018-04-25" version="1">MNDVLDVALRLIVVFVAFLVLPLVVGQTEHKVMAHMQGRLGPMYAGGFHGWAQLVADGVKFAQKEDVVPADADRRIFQLAPAVALLPYLLVLLAIPVGPSEGAVGQVVDAGIFFVLAVMGVGVLGSLMAGWASANKFSLLGGLRTAAQLLAYELPMLLAAASVAMAAGTVSLPGIIEAFEWWWVPWQIVGALVFFVAGLAELQRPPFDMPIADSEIIFGAYTEYTGLRFALFLLAEYAGIVVLCGLTTVLFLGGWHGPWGADGLGWVWTLLKAAVLAFVVIWLRVTYPRLREDQLQKLSWTLLVPLALAQIALTGIVKVAIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JJ43</accession>
    <name>A0A2M9JJ43_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GDP-mannose pyrophosphorylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_37085</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000025">
        <property type="protein sequence ID" value="PJN06894.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN06894">
        <property type="protein sequence ID" value="PJN06894"/>
        <property type="gene ID" value="CG723_37085"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001451">
        <property type="entry name" value="Hexapep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005835">
        <property type="entry name" value="NTP_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00132">
        <property type="entry name" value="Hexapep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00483">
        <property type="entry name" value="NTP_transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NTP_transferase" evidence="1">
        <location>
            <begin position="4"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN06894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="360" mass="37413" checksum="7FDCEF13B54C614B" modified="2018-04-25" version="1">MTEAILLVGGKGTRLRPLTVNTPKPMVPAAGVPFLTHQLARARAAGVEHIVLATSYLAEVFEPYFGDGSRLGLHLEYVTEEEPLGTGGAIRNVASRLHSGPADPVLIFNGDILTGLDIRALVDEHETTGADVSLHLSRVEDPRAFGLVPTDATGRVQAFLEKPQTPEEIVTDQINAGAYVFRRSVIDTIPTGRPVSVERETFPDLLASGAHLQGMVDSTYWLDLGTPQAFVRGSADLVLGRAPSPAVPGRRGDSLTLPTASVAPGAKLTDGTVVCENATVGEGARISGSAVLAGATVEAGAVVTDSLIGRGAHVGARTVLTGAVIGDGATVGPDNELQSGVRVWCDARIPAAAVRFSSDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JJA3</accession>
    <name>A0A2M9JJA3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CG723_36875</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CB01635</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000025">
        <property type="protein sequence ID" value="PJN06857.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN06857">
        <property type="protein sequence ID" value="PJN06857"/>
        <property type="gene ID" value="CG723_36875"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="53"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="79"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="133"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="180"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="19"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PJN06857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="215" mass="22874" checksum="0093F2DDCE30C5B6" modified="2018-04-25" version="1">MTIDWSWVSEHTSDLATLTLSHLQAALSAVLLGLVISLPLAVVAHRVKPLRGFLLGFSNVLFTIPSIAVFVLLLPVSGLTRTTTVIGLTIYTLVVLLRNTVEGLDSVPAKTKEAAKAMGTRPLRTLLTVELPLALPVIMAGVRIATVMAISLVSVATYIGDGGLGQLFTDGFQRNFPTPVIAGVVLTLLLALAADAVLVAVQYVLTPWTRRRRSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JJF2</accession>
    <name>A0A2M9JJF2_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Mannose-6-phosphate isomerase</fullName>
            <ecNumber evidence="3">5.3.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">manA</name>
        <name evidence="7" type="ORF">CG723_37155</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CB01635</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>D-mannose 6-phosphate = D-fructose 6-phosphate</text>
            <dbReference type="Rhea" id="RHEA:12356"/>
            <dbReference type="ChEBI" id="CHEBI:58735"/>
            <dbReference type="ChEBI" id="CHEBI:61527"/>
            <dbReference type="EC" id="5.3.1.8"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="5">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the mannose-6-phosphate isomerase type 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.8" evidence="3"/>
    <dbReference type="EMBL" id="NNBL01000025">
        <property type="protein sequence ID" value="PJN06907.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN06907">
        <property type="protein sequence ID" value="PJN06907"/>
        <property type="gene ID" value="CG723_37155"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004476">
        <property type="term" value="F:mannose-6-phosphate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009298">
        <property type="term" value="P:GDP-mannose biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001250">
        <property type="entry name" value="Man6P_Isoase-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016305">
        <property type="entry name" value="Mannose-6-P_Isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018050">
        <property type="entry name" value="Pmannose_isomerase-type1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10309">
        <property type="entry name" value="PTHR10309"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01238">
        <property type="entry name" value="PMI_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001480">
        <property type="entry name" value="Mannose-6-phosphate_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00714">
        <property type="entry name" value="MAN6PISMRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00218">
        <property type="entry name" value="manA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00965">
        <property type="entry name" value="PMI_I_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0413">Isomerase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="active site" evidence="4">
        <location>
            <position position="270"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="92"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="94"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="129"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="251"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR001480-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR001480-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU004189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PJN06907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="383" mass="40626" checksum="489002A25799D9F9" modified="2018-04-25" version="1">MDRLTNTVRPYAWGSTTAIPHLIGAEPTGEPQAEMWMGAHPGAPSRTGRGPLNEVIDQAPERELGPQAVAKFGPRLPFLLKILAAGAPLSLQVHPDLAQAKEGYEAEERAGVPIDAPHRNYKDANHKPELICALTPFEGLCGFRAPEEAARLIEGLGVDSLKPYADLLRAHPEEAALREVLTAVLSADPAEMAATVTEAEAAAERLGGDYVPYAGLAHHYPGDPGVIAAMLLNHVRLNPGEALFLGAGVPHAYIDGLGVEIMANSDNVLRCGLTPKHVDVPELLRIVRFEATDPGILRPEASPDGEEVYETPIDEFRLSRYTLPEGAAAHDVTAETPQILLCTAGTVRAGELDLTAGQSAFVPAGEKTEVSGVGTLFRATVVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JJN5</accession>
    <name>A0A2M9JJN5_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase</fullName>
            <ecNumber evidence="2">2.7.6.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">folK</name>
        <name evidence="9" type="ORF">CG723_35680</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CB01635</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; tetrahydrofolate biosynthesis; 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate from 7,8-dihydroneopterin triphosphate: step 4/4.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.6.3" evidence="2"/>
    <dbReference type="EMBL" id="NNBL01000023">
        <property type="protein sequence ID" value="PJN07073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN07073">
        <property type="protein sequence ID" value="PJN07073"/>
        <property type="gene ID" value="CG723_35680"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00077">
        <property type="reaction ID" value="UER00155"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003848">
        <property type="term" value="F:2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046656">
        <property type="term" value="P:folic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046654">
        <property type="term" value="P:tetrahydrofolate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00483">
        <property type="entry name" value="HPPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.560">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000550">
        <property type="entry name" value="Hppk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035907">
        <property type="entry name" value="Hppk_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01288">
        <property type="entry name" value="HPPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55083">
        <property type="entry name" value="SSF55083"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01498">
        <property type="entry name" value="folK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00794">
        <property type="entry name" value="HPPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0289">Folate biosynthesis</keyword>
    <keyword evidence="5 9" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="HPPK" evidence="8">
        <location>
            <begin position="124"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS00794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PJN07073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="203" mass="21832" checksum="ADD8C8F3402A9487" modified="2018-04-25" version="1">MTASFTEGPSDPTVQPVPASVVEQVDAADTTLSNPKNAVIALGSNLGNRLETIQGAIDALEDTPGVRVKAVSPVYETEPWGVEPGSQPAYFNAVIVLRTTLPPSSLLERAHAVEEAFHRVRDERWGARTIDVDIVTYADVVSDDPVLTLPHPRAHQRAFVLAPWFDVEPEAQLPGHGPVAELLAAVTREGVAPRADLELQLPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-09-29" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JJU6</accession>
    <name>A0A2M9JJU6_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">50S ribosomal protein L31 type B</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">rpmE2</name>
        <name evidence="5" type="ORF">CG723_35540</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CB01635</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="4">Part of the 50S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the bacterial ribosomal protein bL31 family. Type B subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000023">
        <property type="protein sequence ID" value="PJN07047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN07047">
        <property type="protein sequence ID" value="PJN07047"/>
        <property type="gene ID" value="CG723_35540"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.830.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00502">
        <property type="entry name" value="Ribosomal_L31_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034704">
        <property type="entry name" value="L28p-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002150">
        <property type="entry name" value="Ribosomal_L31"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027493">
        <property type="entry name" value="Ribosomal_L31_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042105">
        <property type="entry name" value="Ribosomal_L31_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33280">
        <property type="entry name" value="PTHR33280"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01197">
        <property type="entry name" value="Ribosomal_L31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01249">
        <property type="entry name" value="RIBOSOMALL31"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143800">
        <property type="entry name" value="SSF143800"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00105">
        <property type="entry name" value="L31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01143">
        <property type="entry name" value="RIBOSOMAL_L31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PJN07047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="84" mass="9654" checksum="9C18E80F2611171C" modified="2018-04-25" version="1">MRKDIHPDYGPVVFRDRAANHAFLTRSTATSDKTVEWEDGRTYPVIDVEISNVSHPFYTGNARVLDTAGRVERFERRFGKRGGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JK37</accession>
    <name>A0A2M9JK37_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Beta-ketoacyl-ACP reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CG723_35205</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000022">
        <property type="protein sequence ID" value="PJN07239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN07239">
        <property type="protein sequence ID" value="PJN07239"/>
        <property type="gene ID" value="CG723_35205"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PJN07239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="253" mass="25987" checksum="4E0621289A360195" modified="2018-04-25" version="1">MSTTEQRVAIVTGAARGIGAATAVRLAAEGRAVAVIDLDEAACKDTVEKITNAGGKALAVGCDVADEAQVEAAVARIAEELGAPTILVNNAGVLRDNLLFKMSALDWDTVMNVHLRGAFLMSKAVQKHMVDAKFGRIVNLSSSSALGNRGQVNYSAAKAGLQGFTKTLAKELGKFGVTANAVAPGFIVTEMTAATAARVGMGFEEFQAAAATQIPVQRVGKPDDIANAIAFFTGEAAGFVSGQVMYVAGGPLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-09-29" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JK72</accession>
    <name>A0A2M9JK72_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">MerR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_35330</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000022">
        <property type="protein sequence ID" value="PJN07262.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN07262">
        <property type="protein sequence ID" value="PJN07262"/>
        <property type="gene ID" value="CG723_35330"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000551">
        <property type="entry name" value="MerR-type_HTH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13411">
        <property type="entry name" value="MerR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00422">
        <property type="entry name" value="HTH_MERR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="SSF46955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50937">
        <property type="entry name" value="HTH_MERR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH merR-type" evidence="2">
        <location>
            <begin position="64"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="193"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN07262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="214" mass="22915" checksum="954F9EF0484A9506" modified="2018-04-25" version="1">MRSSGDGTAGGVGHSPAESGPYSLHGHAAGHIPRRPAVLPVVAQGDDDATPEQVGYRGPTACAAAGITYRQLDYWARTGLVEPSVRPAHGSGTQRLYSFRDVVVLKIVKRFLDTGVSLQNIRTAVQHLRERGFGDLERLTLMSDGATVYECSSPTEVHDLLQGGQGIFGIAVGVVWQDVESALSQLHGERIDTGETLHGNNPADELARRRNRAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JK89</accession>
    <name>A0A2M9JK89_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CG723_34085</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000021">
        <property type="protein sequence ID" value="PJN07286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN07286">
        <property type="protein sequence ID" value="PJN07286"/>
        <property type="gene ID" value="CG723_34085"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046165">
        <property type="entry name" value="DUF6167"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19664">
        <property type="entry name" value="DUF6167"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PJN07286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="114" mass="12747" checksum="8A85BB123E78E3AA" modified="2018-04-25" version="1">MFRRTFWFTAGAAAGVWATTKVNRKLKKLTPESLAAQAANKAIEAGHRLKDFALDVRDGMAEREAELDDALGLSAPVDAELPAQRRFAGVENHVKNNPKYLENTTYSYNRNEDH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JKN6</accession>
    <name>A0A2M9JKN6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Dihydroxyacetone kinase subunit DhaK</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">dhaK</name>
        <name evidence="2" type="ORF">CG723_33600</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000020">
        <property type="protein sequence ID" value="PJN07439.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN07439">
        <property type="protein sequence ID" value="PJN07439"/>
        <property type="gene ID" value="CG723_33600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004371">
        <property type="term" value="F:glycerone kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006071">
        <property type="term" value="P:glycerol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012736">
        <property type="entry name" value="DhaK_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004006">
        <property type="entry name" value="DhaK_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02733">
        <property type="entry name" value="Dak1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02363">
        <property type="entry name" value="dhaK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51481">
        <property type="entry name" value="DHAK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DhaK" evidence="1">
        <location>
            <begin position="7"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN07439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="330" mass="34307" checksum="05B239B190A21868" modified="2018-04-25" version="1">MKMLINVAETVVADALRGMAAAHPELLVDVENRVIARRDAPVEGKVAIVSGGGSGHEPLHGGFVGHGMLSAACPGEVFTSPVPDQMVRAAAAVDSGAGVLFVVKNYTGDVLNFDMAAELAEDEGIQVAKVLVNDDVAVTDSLYTAGRRGTGATLFVEKIAGAAAEEGQPLERVEAIAREVNANARSFGVALSACATPAKGSPTFDLPSGELELGVGIHGEPGRARRAMMTSGEIADFSVDAVLEDLQPSDPVLVLVNGMGATPLLELYGFNAEVQRVLTERGVPVARTLVGNYVTSLDMAGASVTLCQVDEEMLRLWDAPVSTAGLRWGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JKS5</accession>
    <name>A0A2M9JKS5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_33835</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000020">
        <property type="protein sequence ID" value="PJN07476.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN07476">
        <property type="protein sequence ID" value="PJN07476"/>
        <property type="gene ID" value="CG723_33835"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN07476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="89" mass="9886" checksum="8C4E4AC2C8051373" modified="2018-04-25" version="1">MGVRRRRRGRRRERPAESAAHHCLAGGEREACAVPGSPRVRRSLTAADLARRTVSEGYGVCLTYNLVGADRGADVSVFTRRGHTSWPRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JL49</accession>
    <name>A0A2M9JL49_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Protein tyrosine phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CG723_32980</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CB01635</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the low molecular weight phosphotyrosine protein phosphatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000019">
        <property type="protein sequence ID" value="PJN07582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN07582">
        <property type="protein sequence ID" value="PJN07582"/>
        <property type="gene ID" value="CG723_32980"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006470">
        <property type="term" value="P:protein dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023485">
        <property type="entry name" value="Ptyr_pPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036196">
        <property type="entry name" value="Ptyr_pPase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017867">
        <property type="entry name" value="Tyr_phospatase_low_mol_wt"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01451">
        <property type="entry name" value="LMWPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00719">
        <property type="entry name" value="LMWPTPASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00226">
        <property type="entry name" value="LMWPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52788">
        <property type="entry name" value="SSF52788"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LMWPc" evidence="3">
        <location>
            <begin position="3"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PJN07582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="163" mass="17593" checksum="D5FF309B67867E95" modified="2018-04-25" version="1">MSFRVCFVCTGNICRSPMAESVFRTRVHEAGLAGLVEVDSAGTDGWHEGDGADRRTVSVLAAGGYESGHTARQFSASWFSRLDLVIALDAGHLRTLRRLAPTPQDSEKVRLLRSYDPSAGTDLDVPDPYYGGIDDFEECLRMVEAASDGLLDAVRAALEGRAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JL55</accession>
    <name>A0A2M9JL55_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Inositol-3-phosphate synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_33105</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the myo-inositol 1-phosphate synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000019">
        <property type="protein sequence ID" value="PJN07605.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN07605">
        <property type="protein sequence ID" value="PJN07605"/>
        <property type="gene ID" value="CG723_33105"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004512">
        <property type="term" value="F:inositol-3-phosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006021">
        <property type="term" value="P:inositol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002587">
        <property type="entry name" value="Myo-inos-1-P_Synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017815">
        <property type="entry name" value="Myo-inos-1-P_Synthase_actino"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013021">
        <property type="entry name" value="Myo-inos-1-P_Synthase_GAPDH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01658">
        <property type="entry name" value="Inos-1-P_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015578">
        <property type="entry name" value="Myoinos-ppht_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03450">
        <property type="entry name" value="mycothiol_INO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Inos-1-P_synth" evidence="2">
        <location>
            <begin position="191"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN07605.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="360" mass="39651" checksum="F9ADDBC55ACD542A" modified="2018-04-25" version="1">MGSVRVAIVGVGNCAASLVQGVEYYKDADPDAKVPGLMHVQFGDYHVRDIEFVAAFDVDAKKVGLDLSDAIGASENNTIKICDVPNTGVTVQRGHTHDGLGKYYRQTIEESAEAPVDIVQVLKDKQVDVLICYLPVGSEDAAKFYAQCAIDAKVAFVNALPVFIAGTKEWADKFTEAGVPIVGDDIKSQVGATITHRVMAKLFEDRGVRLERTMQLNVGGNMDFKNMLERERLESKKISKTQAVTSQIPDRELGEKNVHIGPSDYVQWLDDRKWAYVRLEGRAFGDVPLNLEYKLEVWDSPNSAGVIIDALRAAKIAKDRGIGGPILSASSYFMKSPPVQYFDDEAYANVEKFIKGEVER</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JL82</accession>
    <name>A0A2M9JL82_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">RNA polymerase sigma factor SigM</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CG723_33140</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CB01635</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000019">
        <property type="protein sequence ID" value="PJN07612.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN07612">
        <property type="protein sequence ID" value="PJN07612"/>
        <property type="gene ID" value="CG723_33140"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050896">
        <property type="term" value="P:response to stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039425">
        <property type="entry name" value="RNA_pol_sigma-70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013249">
        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43133">
        <property type="entry name" value="PTHR43133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08281">
        <property type="entry name" value="Sigma70_r4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="6">
        <location>
            <begin position="29"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4_2" evidence="7">
        <location>
            <begin position="129"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="187"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF08281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PJN07612.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="241" mass="25715" checksum="7B01B5752E9CFC05" modified="2018-04-25" version="1">MDDAAYGEASDQDLLTRHVAGDKDAFGELVRRHRDRLWAVALRTLGDREEAADAVQDALVSAYRAAHTFRGQSAVTTWLHRITVNACLDRARKAASRKTSPVEDAERLEQLLEPHESAAAPAERNDLHRELFEALGTLPVDQRAALVLVDMQGYPVAEAARVLGVPTGTVKSRCARGRARLLPLVTHLRTDNGDSESGKSPPPEAPGRNRTQGTSVPPAAGPRDGAGPNDSAAVKGGGGRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JLU5</accession>
    <name>A0A2M9JLU5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_31045</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000017">
        <property type="protein sequence ID" value="PJN07844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN07844">
        <property type="protein sequence ID" value="PJN07844"/>
        <property type="gene ID" value="CG723_31045"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014851272" evidence="1">
        <location>
            <begin position="41"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN07844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="254" mass="26612" checksum="D989F83CB329A85C" modified="2018-04-25" version="1">MLGRMMPNPVTLKRTVRRFTSTAAGALLAGLALGAAPAHGAERAAALPEFDFSACPTVDELPAGADPGTWRCEVMHATGYLRMGAFDEPLTEPMKITFAEGRVDGEFRQVFGEMTAAPIQVGGTPLTLTPQYGGYSDFLSDDTRRGEFDIKFAIGSAHGLPALPSSGCSVGSDENAVHLVLKDTDPTRVISKDPLVVAFGAQDTEFAAPGTSGCGPLSHPLNRALRLPSAAGANAFDMDVTVAIRPYMQAGSVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-09-29" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JML0</accession>
    <name>A0A2M9JML0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_30925</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000016">
        <property type="protein sequence ID" value="PJN08094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08094">
        <property type="protein sequence ID" value="PJN08094"/>
        <property type="gene ID" value="CG723_30925"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014793049" evidence="1">
        <location>
            <begin position="31"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN08094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="124" mass="13180" checksum="24986CAE07388E17" modified="2018-04-25" version="1">MRKRSRLGAVLTAAALAVTVAGAAAPSASAAGGCWQSGGRWWCNNVSGAPVYGTMGASTQYPDPSRVVGYMNSNPSWFFCKMDGQNWVGGPHPTRWEFTVADNGEYGWMKDTAISSETNPLPNC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JMM3</accession>
    <name>A0A2M9JMM3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_29345</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000015">
        <property type="protein sequence ID" value="PJN08116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08116">
        <property type="protein sequence ID" value="PJN08116"/>
        <property type="gene ID" value="CG723_29345"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN08116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="64" mass="6434" checksum="CB4210D890B949E9" modified="2018-04-25" version="1" fragment="single">MTEHPTSHEGRRPAARPAAPADPRGALRRASDALPAQQGRPGATASADDADPARRGPASGASVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JN79</accession>
    <name>A0A2M9JN79_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Chaplin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CG723_28465</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000014">
        <property type="protein sequence ID" value="PJN08326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08326">
        <property type="protein sequence ID" value="PJN08326"/>
        <property type="gene ID" value="CG723_28465"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007155">
        <property type="term" value="P:cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005528">
        <property type="entry name" value="ChpA-H"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03777">
        <property type="entry name" value="ChpA-C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51884">
        <property type="entry name" value="CHAPLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0034">Amyloid</keyword>
    <keyword evidence="2" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014624600" description="Chaplin domain-containing protein" evidence="5">
        <location>
            <begin position="28"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="domain" description="Chaplin" evidence="6">
        <location>
            <begin position="38"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PJN08326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="92" mass="8525" checksum="C690EA0FD7CF7AB4" modified="2018-04-25" version="1">MSRIAKAAAVALGTGAVVISGAGLAMADAGAQGEAAGSPGVVSGNAVQVPIHVPVNVCGNTVNIIALLNPAFGNACANGDGHNGGDNGGYGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JNB9</accession>
    <name>A0A2M9JNB9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">TetR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CG723_28660</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000014">
        <property type="protein sequence ID" value="PJN08359.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08359">
        <property type="protein sequence ID" value="PJN08359"/>
        <property type="gene ID" value="CG723_28660"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011075">
        <property type="entry name" value="TetR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16859">
        <property type="entry name" value="TetR_C_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="3">
        <location>
            <begin position="31"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="54"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PJN08359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="216" mass="22493" checksum="947068E0656C4F25" modified="2018-04-25" version="1">MPEQAEPGTAPSDPATVQAEPGTVRPGGRTARVRAAVLDAAGDVLAEQGFAHLDLADVARRAEVGKTTVYRRWGSVTGLVADLLADMAEQSLPRTDTGALRGDLRANARLVRRALADPRQGALFRAVIAAAACDEKTSAALRRFYEVRVAEWAPCVEQAVRRGELRAGTDAAAVVRAVSAPLYYQLLTAGSAPTEADADQAADAAVAAAEAGVYTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JNM1</accession>
    <name>A0A2M9JNM1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">LysR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_28940</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LysR transcriptional regulatory family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000014">
        <property type="protein sequence ID" value="PJN08407.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08407">
        <property type="protein sequence ID" value="PJN08407"/>
        <property type="gene ID" value="CG723_28940"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005119">
        <property type="entry name" value="LysR_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000847">
        <property type="entry name" value="Tscrpt_reg_HTH_LysR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00126">
        <property type="entry name" value="HTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03466">
        <property type="entry name" value="LysR_substrate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00039">
        <property type="entry name" value="HTHLYSR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50931">
        <property type="entry name" value="HTH_LYSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH lysR-type" evidence="2">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN08407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="313" mass="34382" checksum="B9CD061BE4FBE486" modified="2018-04-25" version="1">MERQEIEIFLTLAEELHFGRTAERVGVSQSRVSQTIARVERRIGAKLFERSSRRVTMTAIGEQLRDGIGPAQRRIEEEIAKATAAGRGITGTLRIGFSGAFTGHLLHSVAAVFARRHPGVDVQIRQVQISDPYGPLRAGDIDLQVTELPVAEADLTTGPVLLSQPRMLLMPSTHPFARRETLSVEDLAESTLLTVTRPVPAHWLDHHFPRQTPSGRPIPHGQAITHWEDALSLVLAGKGVTPVAAAGVRYYARPGLVFRPFSDAPRIEYAFIWPTDHETGRLRAFVGAALEHVRSLGGPTRALETLWESESGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-05-25" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JNP2</accession>
    <name>A0A2M9JNP2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_28475</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000014">
        <property type="protein sequence ID" value="PJN08488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08488">
        <property type="protein sequence ID" value="PJN08488"/>
        <property type="gene ID" value="CG723_28475"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="42"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="70"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN08488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="173" mass="17103" checksum="6B266412904A4993" modified="2018-04-25" version="1">MTVFLGLGIAGLVLLVLALVFDGVLEGLFGGAGFLDGLFDGLLSLPVVAGFVSMLGFGGALVLGTTGLGAGPATAVGAGAGVAAGWLTWRLSRALMRDQDGSAPRGDDLVGTAGSVVTAIPADGYGEVLLRLAGQPVKLAAKSAGATAVARGSEIWVEESLSPTSVAVRPVQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-06-02" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JPE2</accession>
    <name>A0A2M9JPE2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_27110</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000012">
        <property type="protein sequence ID" value="PJN08753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08753">
        <property type="protein sequence ID" value="PJN08753"/>
        <property type="gene ID" value="CG723_27110"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN08753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="68" mass="7941" checksum="BEF564569798EC41" modified="2018-04-25" version="1">MGMKDQFQDKAEQLANQAKKRSGHGRDEASERSTRTQDDLRRERGSQSEDSERRRQEAQDRIDQGYDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JPX7</accession>
    <name>A0A2M9JPX7_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Transcription termination factor Rho</fullName>
            <ecNumber evidence="8">3.6.4.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">ATP-dependent helicase Rho</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">rho</name>
        <name evidence="12" type="ORF">CG723_25725</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">CB01635</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homohexamer. The homohexamer assembles into an open ring structure.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8 9">Belongs to the Rho family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.-" evidence="8"/>
    <dbReference type="EMBL" id="NNBL01000011">
        <property type="protein sequence ID" value="PJN08895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08895">
        <property type="protein sequence ID" value="PJN08895"/>
        <property type="gene ID" value="CG723_25725"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008186">
        <property type="term" value="F:ATP-dependent activity, acting on RNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006353">
        <property type="term" value="P:DNA-templated transcription, termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04459">
        <property type="entry name" value="Rho_CSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01128">
        <property type="entry name" value="rho_factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01884">
        <property type="entry name" value="Rho"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000194">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_nucl-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011129">
        <property type="entry name" value="CSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041703">
        <property type="entry name" value="Rho_factor_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011112">
        <property type="entry name" value="Rho_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036269">
        <property type="entry name" value="Rho_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011113">
        <property type="entry name" value="Rho_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004665">
        <property type="entry name" value="Term_rho"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46425">
        <property type="entry name" value="PTHR46425"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00006">
        <property type="entry name" value="ATP-synt_ab"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07498">
        <property type="entry name" value="Rho_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07497">
        <property type="entry name" value="Rho_RNA_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00357">
        <property type="entry name" value="CSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00959">
        <property type="entry name" value="Rho_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF68912">
        <property type="entry name" value="SSF68912"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00767">
        <property type="entry name" value="rho"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51856">
        <property type="entry name" value="RHO_RNA_BD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 8" id="KW-0347">Helicase</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8 9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="7 8" id="KW-0804">Transcription</keyword>
    <keyword evidence="6 8" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="1 8" id="KW-0806">Transcription termination</keyword>
    <feature type="domain" description="Rho RNA-BD" evidence="11">
        <location>
            <begin position="301"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="75"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="89"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="144"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="170"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="237"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="252"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="419"/>
            <end position="424"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="431"/>
            <end position="436"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="462"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PJN08895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="678" mass="72840" checksum="C1AED66E3C3F5D93" modified="2018-04-25" version="1">MSDTTDLMGVSADSSAVAPSADADAPAAGAAGSRRRRGTGLEGMVLAELQQVASGLGIRGTARMRKSQLIEVIKEAQAGGGAPAKSADTTETKPKRRATSKARTGDEAAANGTEAPAKAAKAEDAKAAKAAAQQQIDIPGQPASDEKGGERRRRRATSEAGSPETVTAEAKTETKTDAQGEAKGDAGDNGAEGRRERRDRRDRGGDRGDRGGDRGERGGRDRGDRRGKGDEQGKEQGGGNRQPQGGGRQDRQRDNGPQDDGFDDEGGRRGRRGRYRDRRGRRGRDEAGFGNEVQVSEDDVLIPVAGILDILDNYAFIRTSGYLPGPNDVYVSLAQVRKNGLRKGDHVTGAVRQPKDGERREKFNALVRLDSANGMAAESGRGRPEFNKLTPLYPQDRLRLETDPGILTTRIIDLVSPIGKGQRGLIVAPPKTGKTMILQAVANAITVNSPECHLMVVLVDERPEEVTDMQRSVKGEVISSTFDRPAEDHTTVAELAIERAKRLVELGHDVVVLLDSITRLGRAYNLAAPASGRILSGGVDSTALYPPKRFFGAARNIEDGGSLTILATALVDTGSRMDEVIFEEFKGTGNMELKLDRKLSDKRIFPAVDVDASSTRKEEILLNAEELAIVWKLRRVLHALDSQQAIELLLDKMKQTKSNAEFLMQIAKTTPTPGNGND</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-05-25" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JQB2</accession>
    <name>A0A2M9JQB2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Bifunctional metallophosphatase/5'-nucleotidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CG723_24330</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CB01635</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 5'-nucleotidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000010">
        <property type="protein sequence ID" value="PJN09060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN09060">
        <property type="protein sequence ID" value="PJN09060"/>
        <property type="gene ID" value="CG723_24330"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009166">
        <property type="term" value="P:nucleotide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07412">
        <property type="entry name" value="MPP_YhcR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.780.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008334">
        <property type="entry name" value="5'-Nucleotdase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036907">
        <property type="entry name" value="5'-Nucleotdase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006179">
        <property type="entry name" value="5_nucleotidase/apyrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041831">
        <property type="entry name" value="YhcR_MPP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11575">
        <property type="entry name" value="PTHR11575"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02872">
        <property type="entry name" value="5_nucleotid_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01607">
        <property type="entry name" value="APYRASEFAMLY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55816">
        <property type="entry name" value="SSF55816"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="SSF56300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014493900" evidence="1">
        <location>
            <begin position="39"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="domain" description="5_nucleotid_C" evidence="3">
        <location>
            <begin position="396"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="64"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU362119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PJN09060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="603" mass="62891" checksum="ABE5FCE763CB7925" modified="2018-04-25" version="1">MTPLTPHRPGRRAASRLLAAAAGFATVGALVAALPANATQDRHHGDEHRRTVDVQLLSFNDFHGNLEPPAGSSGQVTENLPDGTTRKVDAGGVEYLATSLRTARKSHPYSVTAAAGDLIGASPLLSGLFHDEPTVEAMNKLDLDVTSVGNHEFDEGATELARMQNGGCHPKDGCFEDGKKFKGADYPYLAANVTNEKTGKPILAPYWVWKHNGVKIGFIGVTLEGTPDIVSADGVKGLKFHDEIETVNKYAKILDKQGVKSIVTLIHEGGVPASGSYNYDCDSPSGGAGISGPIVDIAKGISPKVDALVTGHTHNAYVCTIPDPSGKPRMVTSASSYGKLYTDTTLTYDRRTKDIVRTSVKSANHVVSRTQPKAADMTALIGRWNKMAAPVAGQPVGYISADIPGRGAASPEAPLGDLIADAQLAHAKSLDPKTSLALMNPGGVRSDLVYKASGSEGDGVVTYGEGFTVQPFSNTVNLADLTGAQVIAALQQQVSGSNESSPKILQPSAGLTYTLDMTKAGAARVVVDSIRLNGAAIDPAATYRVAMNSFLAGGGDGFAALGQGKNPLVGSDDLKAFNDYLTANSSATSPIAPPKADRITIVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JQE5</accession>
    <name>A0A2M9JQE5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CG723_24495</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000010">
        <property type="protein sequence ID" value="PJN09086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN09086">
        <property type="protein sequence ID" value="PJN09086"/>
        <property type="gene ID" value="CG723_24495"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PJN09086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="62" mass="6522" checksum="AD8D92B06F69A856" modified="2018-04-25" version="1">MPVLTFFSAVFVITFEQLVQWRYGPVGIAGLLLLTIGVKTKSPTCSSIGAVLLALMIAGPAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-06-02" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JQF1</accession>
    <name>A0A2M9JQF1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Serine hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CG723_24610</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000010">
        <property type="protein sequence ID" value="PJN09102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN09102">
        <property type="protein sequence ID" value="PJN09102"/>
        <property type="gene ID" value="CG723_24610"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001466">
        <property type="entry name" value="Beta-lactam-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00144">
        <property type="entry name" value="Beta-lactamase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014618170" evidence="2">
        <location>
            <begin position="33"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-lactamase" evidence="3">
        <location>
            <begin position="77"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="41"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="269"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="41"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PJN09102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="427" mass="45644" checksum="6DFAA42D8593BC25" modified="2018-04-25" version="1">MTHSSRGLRRGAVTAVAVGTLAVPIAGGSAFATPAAVSTGSSSASLVRATDPPSPSDSGSTAPGQVQKLTPAVEKELDAAVQKVMREANVPGVTFGVWTPDKGEYVKSFGVADKSTGQKMSPNLHMRIGSETKTFTVTSILKLVDEKKVGLDDPIGKYIDGVPNGDKITIRQLAEMRSGLFNYSEDEDFYKALTSDPNRPFTPQQLLDYSFKHPVLFAPGEKFYYCNTNLILLGLVVEKESGRPLNEYIRDNILTPAGMKQTLFPTGNEFPEPHSQGYTNQTASGKTKDSADWNPSWGWAAGAMISTLNDLRIWAPTVATGKFPDGNTMISPATQKQRLITPKTTIPGAGYGLGIFNVQGWIGHNGSLPGYESLTIYLPSAKATLVVVLNTDVNHDNSEPSTLVGQAITKIISPSNIFNLPAQPAAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-09-29" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JRH4</accession>
    <name>A0A2M9JRH4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_22105</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000008">
        <property type="protein sequence ID" value="PJN09469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN09469">
        <property type="protein sequence ID" value="PJN09469"/>
        <property type="gene ID" value="CG723_22105"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.320.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036625">
        <property type="entry name" value="E3-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024412">
        <property type="entry name" value="Lsr2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042261">
        <property type="entry name" value="Lsr2_dimerization"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11774">
        <property type="entry name" value="Lsr2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="63"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN09469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="118" mass="12846" checksum="B63EA4FF80D8C195" modified="2018-04-25" version="1">MAQREVITYTDDLTGEEAEEIGTHTILIDGAGVEIDLSTENHDRLLEVLHPYFSAEGARRVRGSVTTAGTRGKRRAAGPSAHSDTAQIRAWAKENGLEVNDRGRVPASVKEAYEKAND</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JRV7</accession>
    <name>A0A2M9JRV7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Hydroxypyruvate isomerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CG723_22880</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CB01635</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the hyi family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000008">
        <property type="protein sequence ID" value="PJN09582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN09582">
        <property type="protein sequence ID" value="PJN09582"/>
        <property type="gene ID" value="CG723_22880"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026040">
        <property type="entry name" value="HyI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036237">
        <property type="entry name" value="Xyl_isomerase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013022">
        <property type="entry name" value="Xyl_isomerase-like_TIM-brl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01261">
        <property type="entry name" value="AP_endonuc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006241">
        <property type="entry name" value="HyI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51658">
        <property type="entry name" value="SSF51658"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AP_endonuc_2" evidence="3">
        <location>
            <begin position="21"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="2">
        <location>
            <position position="143"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="2">
        <location>
            <position position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRNR" id="PIRNR006241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR006241-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PJN09582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="264" mass="28956" checksum="555CE195692EE6C4" modified="2018-04-25" version="1">MPRFAANLSTLYPEHDFPDRFAAAAADGFEAVEYLFPYAYEATDLRRRLDGHGLRQVLFNAPPGDWDAGERGIAALPGRETEVRDGVERALEYAAALDCPRVHMMAGLVPQSADPAPYRATYLSNLAYAAEQAATVGVDILIEPINGRDMPGYFLSRQADAHAVVQEVGAPNLKVQLDLYHCQIVEGDLTATLRRDLPTGRVAHLQIAGVPDRHEPDAGELNLRHLMSVVDELGFDGWIGCEYFPKAGTSEGLGWRHKFQGDNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JRV8</accession>
    <name>A0A2M9JRV8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_23100</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000008">
        <property type="protein sequence ID" value="PJN09615.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN09615">
        <property type="protein sequence ID" value="PJN09615"/>
        <property type="gene ID" value="CG723_23100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002397">
        <property type="entry name" value="Cyt_P450_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00359">
        <property type="entry name" value="BP450"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="SSF48264"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0349">Heme</keyword>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN09615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="404" mass="44457" checksum="9E7063A88E187561" modified="2018-04-25" version="1">MTVTVLDTTGTQLYEQADHLRAAGPATRVEMPAGLIAWSVTRGEVVTKLLVDPRVSKDARKSWPGYRLFAVPWLAAWVDVISMFTTDGDDHQRLKNLVGKAFTARRIEAMGPAIEAVVTRLLDQMETHGPGARLDLRTEFSYPVPTSVICDLFGVPEEQRPQMLKVIDSVLDSSADDDRATEIRDAMYRAMQTLIAHKRDQPGEDMTSVLLETQQAGDDPLTGDELVSTLILMIGAGSETAVSLINHAVVELAQHPDQLAAVLADPSRWDDVVEETLRKHPPIMHLPLRYATDDIDLGGNLTIRKGDLILIGFGAHGRDPEANPDPGQFNIDREDRRHLAFGHGIHFCLGAALARLEARVALPALFHRFPRLQLATQPAELQPQSSFIGNDYRSVPVKLTPDAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-05-25" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JS44</accession>
    <name>A0A2M9JS44_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">AfsR/SARP family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CG723_21090</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CB01635</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AfsR/DnrI/RedD regulatory family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000007">
        <property type="protein sequence ID" value="PJN09700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN09700">
        <property type="protein sequence ID" value="PJN09700"/>
        <property type="gene ID" value="CG723_21090"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd15831">
        <property type="entry name" value="BTAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005158">
        <property type="entry name" value="BTAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03704">
        <property type="entry name" value="BTAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01043">
        <property type="entry name" value="BTAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0902">Two-component regulatory system</keyword>
    <feature type="domain" description="OmpR/PhoB-type" evidence="5">
        <location>
            <begin position="1"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="3">
        <location>
            <begin position="1"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PJN09700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="1006" mass="107639" checksum="756DCBC1C967AC47" modified="2018-04-25" version="1">MRFGILGPLDVRAPDGTPLDPGGPRPRALLTLLLLEAGRTVSAERLIDGLYGDEPPAGAANALQSQVSRLRKRLSLDIEATPAGYRLAVGPDDVDVHRFERLAAEGERSLSSGDPSLASALLGEALGLWRGPALADLPAAFGSRLDEIRFTATQSRIEAELALGSGGGLVPELRELIAAHPLSERLYGQLMRALHAGGRAAEALAVYEEVRRVLADELGADPSAELSALHLELLRGREPARGRGVPAQLTRFVGRTDELSRIDALLAGSRLVTLTGPGGAGKTRLAAEAARDGADVCWAELAPLADGEQMPYALLAALGVREGFRGPQGDPVARLIDALEGRDVLLVLDNCEHLVDDAARTAVVLLGACPGLRILATSREALGITGEALCPVPPLAAGPAARLFMDRAAAVRPDADLHARVEAVHAICEALDGLPLAIELAAARLRTLTVDELAARLGDRFRLLSRGDRTKAPRHRTLRAVVEWSWELLDEEERDLARRMAVFAGGSSGGATLAAVEAVCGVPYPEDLLASLTEKSFLEAAGGRYRMLQTIRAFCTEHLADEGELSRLRDAHAAYFQGLAAQAEPYLRGGGQLPRLAALGAEQDNLSAALRHLVRADPHAALRLMADLSWFWRLRGLHGAHVPLARELLAALGDEPPEDLAEEYVLCVINTVTGEGNDPREAERLARAEAVLASRDHALRRPFVVVLWSVTYGPQHAVQERVRRQVGEAPWGLALLDVGLGFQEWFAGRPVTSEEHFERALDGFRATGDRWGMANCLDPLGMFADWRGDRERALALLDEGLAHVAALEAPEETADLLHRRAYVLLHQGQLRDAADHFTRSAAMARTAAVPDKVASARRGLGDVARIGGDTEHARVHYEAALELCAANWFSVGETVRTLIGLGRAALAASRPDEARDWFEQGLALCDGPTRALELADAAEALASVAQDPREAAVLLGAGAGLRGRALAGDPDVTPVEARVRAALTTETYEKAFEEGRAMRSAAVSRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JS54</accession>
    <name>A0A2M9JS54_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Phosphopantetheine adenylyltransferase</fullName>
            <ecNumber evidence="6">2.7.7.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Dephospho-CoA pyrophosphorylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Pantetheine-phosphate adenylyltransferase</fullName>
            <shortName evidence="6">PPAT</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">coaD</name>
        <name evidence="8" type="ORF">CG723_21115</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CB01635</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Reversibly transfers an adenylyl group from ATP to 4'-phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5 6">
            <text>(R)-4'-phosphopantetheine + ATP + H(+) = 3'-dephospho-CoA + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:19801"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57328"/>
            <dbReference type="ChEBI" id="CHEBI:61723"/>
            <dbReference type="EC" id="2.7.7.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="6">Cofactor biosynthesis; coenzyme A biosynthesis; CoA from (R)-pantothenate: step 4/5.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homohexamer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the bacterial CoaD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.3" evidence="6"/>
    <dbReference type="EMBL" id="NNBL01000007">
        <property type="protein sequence ID" value="PJN09705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN09705">
        <property type="protein sequence ID" value="PJN09705"/>
        <property type="gene ID" value="CG723_21115"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00241">
        <property type="reaction ID" value="UER00355"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004595">
        <property type="term" value="F:pantetheine-phosphate adenylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015937">
        <property type="term" value="P:coenzyme A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02163">
        <property type="entry name" value="PPAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00151">
        <property type="entry name" value="PPAT_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004821">
        <property type="entry name" value="Cyt_trans-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001980">
        <property type="entry name" value="PPAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21342:SF1">
        <property type="entry name" value="PTHR21342:SF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01467">
        <property type="entry name" value="CTP_transf_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01020">
        <property type="entry name" value="LPSBIOSNTHSS"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01510">
        <property type="entry name" value="coaD_prev_kdtB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00125">
        <property type="entry name" value="cyt_tran_rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 6" id="KW-0173">Coenzyme A biosynthesis</keyword>
    <keyword evidence="1 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2 6 8" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="CTP_transf_like" evidence="7">
        <location>
            <begin position="16"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="19"/>
            <end position="20"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="19"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="27"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="51"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="83"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="97"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="98"/>
            <end position="100"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="108"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="132"/>
            <end position="138"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="6">
        <location>
            <position position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00029346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PJN09705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="169" mass="18646" checksum="7F0AF00680890A38" modified="2018-04-25" version="1">MTGPESEGLTLRRAVCPGSFDPITNGHLDIIGRASKLYDVVHVAVMINQSKKGLFEIEERIELIREVTAEFGNVEVESFHGLLVDFCKQRDIPAIVKGLRAVSDFDYELQMAQMNNGLTGVETLFVPTNPTYSFLSSSLVKEVAAWGGDVSHLVPPVVFEALTQRLPKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-05-25" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JSR5</accession>
    <name>A0A2M9JSR5_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 11">Cytidine deaminase</fullName>
            <ecNumber evidence="6 11">3.5.4.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10 11">Cytidine aminohydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CG723_19315</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">CB01635</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4 11">This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 11">
            <text>2'-deoxycytidine + H(+) + H2O = 2'-deoxyuridine + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:13433"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15698"/>
            <dbReference type="ChEBI" id="CHEBI:16450"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="EC" id="3.5.4.5"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>cytidine + H(+) + H2O = NH4(+) + uridine</text>
            <dbReference type="Rhea" id="RHEA:16069"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16704"/>
            <dbReference type="ChEBI" id="CHEBI:17562"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="EC" id="3.5.4.5"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3 11">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="5 11">Belongs to the cytidine and deoxycytidylate deaminase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.5" evidence="6 11"/>
    <dbReference type="EMBL" id="NNBL01000006">
        <property type="protein sequence ID" value="PJN09893.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN09893">
        <property type="protein sequence ID" value="PJN09893"/>
        <property type="gene ID" value="CG723_19315"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004126">
        <property type="term" value="F:cytidine deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047844">
        <property type="term" value="F:deoxycytidine deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016192">
        <property type="entry name" value="APOBEC/CMP_deaminase_Zn-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002125">
        <property type="entry name" value="CMP_dCMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006262">
        <property type="entry name" value="Cyt_deam_tetra"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016193">
        <property type="entry name" value="Cytidine_deaminase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00383">
        <property type="entry name" value="dCMP_cyt_deam_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53927">
        <property type="entry name" value="SSF53927"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01354">
        <property type="entry name" value="cyt_deam_tetra"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00903">
        <property type="entry name" value="CYT_DCMP_DEAMINASES_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51747">
        <property type="entry name" value="CYT_DCMP_DEAMINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 11" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="CMP/dCMP-type deaminase" evidence="12">
        <location>
            <begin position="4"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000393"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00000631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00003949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00006576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00018266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00032005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU364006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PJN09893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="129" mass="13787" checksum="25F3CEC23010DF1D" modified="2018-04-25" version="1">MTEADWEALREAAREAMSRAYVPYSAFPVGAAARVDDGRTVSGCNVENASYGLGLCAECGLVSQLQLTGGGRLTHFTCVDGKGEILMPCGRCRQLLYEFGGTELLLETTSGIRPLGEMLPDAFGPQHLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JSS9</accession>
    <name>A0A2M9JSS9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Peptide-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_19600</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000006">
        <property type="protein sequence ID" value="PJN09939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN09939">
        <property type="protein sequence ID" value="PJN09939"/>
        <property type="gene ID" value="CG723_19600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042597">
        <property type="term" value="C:periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030678">
        <property type="entry name" value="Peptide/Ni-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039424">
        <property type="entry name" value="SBP_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000914">
        <property type="entry name" value="SBP_5_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30290">
        <property type="entry name" value="PTHR30290"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00496">
        <property type="entry name" value="SBP_bac_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002741">
        <property type="entry name" value="MppA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014805977" evidence="1">
        <location>
            <begin position="23"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="domain" description="SBP_bac_5" evidence="2">
        <location>
            <begin position="78"/>
            <end position="435"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN09939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="518" mass="56491" checksum="88E7A4FBC4D900C3" modified="2018-04-25" version="1">MRSIRMRVFATFMVLAAAGAGAWQLLPDRDEQGKTITVGTTDAVTSLDPAGAYDAGSWALYSNVFQSLLTFDAGGAAPVPDAAKHCGFVGQGLLTYRCELRDGLTFPSGRAVTAKDVKFSFDRVKAIDSPVGPATLLDTLGKVETSGARTVTFQLSSPDATFPFKVATGAGSIVDSTQYPARSLRTRTRVDGTGPYSLSSYTPGKQAKLVPNSRYQGAVKSVGKPTTLRYFKDSAALEAAWKARSVDVAARQLPPALLASYAPSDKGERLTEVESAETRNLVLNVRTGRPLHDRRVRQALATLLDRDRLVASTYQGTVDSLYSLIPRGITGHTTAFFDAYPKPDAARARKLLQEAGVSAPVRFEFAYSRGAASASEAKEIKRQLEASGLFKVSLRYYEWTDFQTRYASGKLDAYAVGWLPDFPDPDTFTAQLVRTGSGMHNGYSSKEVDGLIQASQQYEDRSRTMGDFRKLQEAVARDVPLIPLWQRKEYVLSTEDITGGQYLSDGTGVFRLWQLGWI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JSX4</accession>
    <name>A0A2M9JSX4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Gluconolactonase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_19545</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000006">
        <property type="protein sequence ID" value="PJN09932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN09932">
        <property type="protein sequence ID" value="PJN09932"/>
        <property type="gene ID" value="CG723_19545"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013658">
        <property type="entry name" value="SGL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005511">
        <property type="entry name" value="SMP-30"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08450">
        <property type="entry name" value="SGL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01790">
        <property type="entry name" value="SMP30FAMILY"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SGL" evidence="1">
        <location>
            <begin position="38"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN09932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="309" mass="33934" checksum="02E01C55B2E3EE86" modified="2018-04-25" version="1">MSGQNQPSVYEILDERFRTGRCAFGDDSLTTLHTGSRWAEGPVYLPAWRQLIWSDIPNDRLLRWDEATGAVSLFRTPAGHTNGNTLDREGRLVSAEQGGRRVTRTEADGRITVLADRFEGKRLNSPNDAVVRSDGSIWFSDPDFGITSDYEGFRAESEIGANNVYRIDPATGEVRQVADGFGAPNGLVFSPDERQLYVSDTRAGCIRVFDVQDDGESLSDGKVFAETSGDDGRFDNIRFDDGGRLWAAAMHGGVHCYDPDGTRIGRIDVPEPVSNVAFGGPKNNILFITATTSLYCLMTSVTGAPRIRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JT33</accession>
    <name>A0A2M9JT33_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 6">50S ribosomal protein L13</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4 6" type="primary">rplM</name>
        <name evidence="7" type="ORF">CG723_20165</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CB01635</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4 6">This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Part of the 50S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4 5">Belongs to the universal ribosomal protein uL13 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000006">
        <property type="protein sequence ID" value="PJN10034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN10034">
        <property type="protein sequence ID" value="PJN10034"/>
        <property type="gene ID" value="CG723_20165"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00392">
        <property type="entry name" value="Ribosomal_L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01366">
        <property type="entry name" value="Ribosomal_L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005822">
        <property type="entry name" value="Ribosomal_L13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005823">
        <property type="entry name" value="Ribosomal_L13_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023563">
        <property type="entry name" value="Ribosomal_L13_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036899">
        <property type="entry name" value="Ribosomal_L13_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11545">
        <property type="entry name" value="PTHR11545"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00572">
        <property type="entry name" value="Ribosomal_L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002181">
        <property type="entry name" value="Ribosomal_L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52161">
        <property type="entry name" value="SSF52161"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01066">
        <property type="entry name" value="rplM_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00783">
        <property type="entry name" value="RIBOSOMAL_L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01366"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003877"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PJN10034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="147" mass="16383" checksum="3FBE33E2D065FA8B" modified="2018-04-25" version="1">MRTYSPKPGDITRQWYVIDAQDVVLGRLATTAANILRGKHKPIYAPHVDAGDFVIIINADKVHLSGNKKTQKMAYRHSGYPGGLRSVRYDELLDKNPEKAVEKAIKGMIPKNTLGRQVLSKLKVYSGDQHPHAAQQPVPFEITQVAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-06-02" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JT90</accession>
    <name>A0A2M9JT90_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_20610</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000006">
        <property type="protein sequence ID" value="PJN10106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN10106">
        <property type="protein sequence ID" value="PJN10106"/>
        <property type="gene ID" value="CG723_20610"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.150.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018511">
        <property type="entry name" value="Hemolysin-typ_Ca-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001343">
        <property type="entry name" value="Hemolysn_Ca-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011049">
        <property type="entry name" value="Serralysin-like_metalloprot_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00353">
        <property type="entry name" value="HemolysinCabind"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51120">
        <property type="entry name" value="SSF51120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00330">
        <property type="entry name" value="HEMOLYSIN_CALCIUM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="79"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="113"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN10106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="140" mass="13547" checksum="CF08B6EC258BFAEB" modified="2018-04-25" version="1">MGPAQVTITYEPVPPTCANVTPANPQGFNIITGTNRSDILNGTPGPDAIFGLGGNDVINGLGGNDLLCGGDGNDALSGGDGNDRIEGGNGADNLNGNNGNDALLGGPGNDALFGGTGTNTNDGGPGTNACFNPSTGPGCF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JTB1</accession>
    <name>A0A2M9JTB1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA primase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_20710</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000006">
        <property type="protein sequence ID" value="PJN10126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN10126">
        <property type="protein sequence ID" value="PJN10126"/>
        <property type="gene ID" value="CG723_20710"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015330">
        <property type="entry name" value="DNA_primase/pol_bifunc_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09250">
        <property type="entry name" value="Prim-Pol"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00943">
        <property type="entry name" value="Prim-Pol"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Prim-Pol" evidence="1">
        <location>
            <begin position="9"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN10126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="297" mass="31569" checksum="B8D90A7210146DDB" modified="2018-04-25" version="1">MSEHLMRAALDAAERGWHVFPLRPDTKRPALHGEAACPRTGACESGHRKWEQRATTDPDRIRATWARGPFNVGIATGPSELLVVDLDMPKPNSNGDTPDGATTFKALCERTGHTVPTTYRTRTASGGHHLYFTAPNGTRLSNTAGTIAPLVDTRAWGGYVVAAGSTTPAGNYEAAGSPMAPALPLWLLSILKPAPKPPQAPSTATAGQSRRYADTALACEARSVAGAQLGEREAKLFRAARALGRFVAWGDLPRHVVEHALQEAGEAAGLPASQCRATLRSALNWSVAHNHRRQGAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JTM0</accession>
    <name>A0A2M9JTM0_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cytochrome bc1 complex Rieske iron-sulfur subunit</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Cytochrome bc1 reductase complex subunit QcrA</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CG723_17710</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">CB01635</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Iron-sulfur subunit of the cytochrome bc1 complex, an essential component of the respiratory electron transport chain required for ATP synthesis. The bc1 complex catalyzes the oxidation of menaquinol and the reduction of cytochrome c in the respiratory chain. The bc1 complex operates through a Q-cycle mechanism that couples electron transfer to generation of the proton gradient that drives ATP synthesis.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>2Fe-2S cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49601"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000005">
        <property type="protein sequence ID" value="PJN10230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN10230">
        <property type="protein sequence ID" value="PJN10230"/>
        <property type="gene ID" value="CG723_17710"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.102.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017941">
        <property type="entry name" value="Rieske_2Fe-2S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036922">
        <property type="entry name" value="Rieske_2Fe-2S_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014349">
        <property type="entry name" value="Rieske_Fe-S_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005805">
        <property type="entry name" value="Rieske_Fe-S_prot_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10134">
        <property type="entry name" value="PTHR10134"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00355">
        <property type="entry name" value="Rieske"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00162">
        <property type="entry name" value="RIESKE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50022">
        <property type="entry name" value="SSF50022"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51296">
        <property type="entry name" value="RIESKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0408">Iron</keyword>
    <keyword evidence="8" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rieske" evidence="12">
        <location>
            <begin position="79"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00029586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PJN10230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="218" mass="22857" checksum="DCD93F76B468AC8B" modified="2018-04-25" version="1">MSVTEQPPVPEPGTDDDAAQAALEDRISADSLTTRRDYLRIVATVSGGLAVGGIAVAGGVLHRHGDTDSAPEPKRVTGRLAPGESIAFRFPGEDDRAVAVRLTDGSLVGYSAVCTHLACGVLWRKDRGSEGELYCPCHEGIFDARTGEVTAGPPPRGLPKVLLVEQGDGSVWAVATARSGENAQDAVCREFADARPEVRAQLGCPVANDANGERSQRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JTQ7</accession>
    <name>A0A2M9JTQ7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Peptide ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_17840</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000005">
        <property type="protein sequence ID" value="PJN10254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN10254">
        <property type="protein sequence ID" value="PJN10254"/>
        <property type="gene ID" value="CG723_17840"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004668">
        <property type="term" value="F:protein-arginine deiminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009446">
        <property type="term" value="P:putrescine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007466">
        <property type="entry name" value="Peptidyl-Arg-deiminase_porph"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31377">
        <property type="entry name" value="PTHR31377"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04371">
        <property type="entry name" value="PAD_porph"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN10254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="364" mass="40027" checksum="CF73F863C57EAECC" modified="2018-04-25" version="1">MNEPPLGRRLLDTLFGASPSRQAGYDSAADDGWHVPADDVPHVRTWMSWPASRSIWGRRLSGVQQDIALIARTVAAYEAVIMCAPDEDTADDARAACGRDVTVITSIPTDDLWMRDTCAVFRRDGRGNRDAVGLNFNGWGHKQTHRDDAAVAEWVAEFNELEFEWVDFVGEGGSIETDGDGTVMATESSLVNKNRNRGMSRTEIEEAVLHAYGAEKMIWVPGVRGRDITDNHIDVTSRFISPGVVMVQIPPGDRGDVWARDAREQFAILSGETDARGRRLQVIQVDGPETVRSRSSQFVDSYLNFHVVNGAVITAQFGDRTKDHAARQALSDAFPGREVIQLDVDRLMGGGGGIHCSTMHEPVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JTW0</accession>
    <name>A0A2M9JTW0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Endonuclease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_17910</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000005">
        <property type="protein sequence ID" value="PJN10268.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN10268">
        <property type="protein sequence ID" value="PJN10268"/>
        <property type="gene ID" value="CG723_17910"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03372">
        <property type="entry name" value="Exo_endo_phos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="SSF56219"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="33"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="57"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="domain" description="Endo/exonuclease/phosphatase" evidence="2">
        <location>
            <begin position="106"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN10268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="339" mass="35908" checksum="FB341072761D9E6B" modified="2018-04-25" version="1">MLAALAVVTAGPLAFHRAVPNSVGHLGSLLEQFLPWLGLVVVVLLLLALVRRSAAALVALLLPVAAWTYLCGGLLLPGKTPGAHDLVVAQHNVSDVNTDPAGTARALADAGPDLIALEELLPVARPVYDKTLAPRYPYHAVRGTVGLWSKHPLTDVWMVDIKPLGITRSWERGLRAVVHAPRGEIAVYVAHLPSVRVGAGGLGSTWRDESARMLGQAVAAEKVKPVILLGDLNSTVDDRGLAPLTSRMNTAERGFAFSFPAAFPVARIDQVMARSATVTQIRTLPETGSDHLPVAARIALGPGVSPSRHPRSMAATHDVRTAGRRAVRVPASTPGPRHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JU09</accession>
    <name>A0A2M9JU09_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GNAT family N-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_18580</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000005">
        <property type="protein sequence ID" value="PJN10375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN10375">
        <property type="protein sequence ID" value="PJN10375"/>
        <property type="gene ID" value="CG723_18580"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="4"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN10375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="151" mass="16929" checksum="4BA2F5D4DA96F647" modified="2018-04-25" version="1">MTDLRIEKVQGDALIEDWRHVHNLIIPADPLSLDDVRERVGRNHLEIAYLGDTLVGCTTVRPPTDDTATATVIARVLPDHRRQGFGEVLYRHGLEHARTLDAAVIETVILASNVAGVRFAEKHGFVEVERYVLPEDPALWFTMRLAEDGLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JUA6</accession>
    <name>A0A2M9JUA6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CG723_18790</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000005">
        <property type="protein sequence ID" value="PJN10408.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN10408">
        <property type="protein sequence ID" value="PJN10408"/>
        <property type="gene ID" value="CG723_18790"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PJN10408.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="77" mass="8270" checksum="A51033CC0BAC5DED" modified="2018-04-25" version="1">MLIALPVLSAAVPALEFTDSLAPVVLGAPVWGAATGVQEATRRAVVADLVAPRRRATASSPRSWVWPRWMEMSWSAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JUH1</accession>
    <name>A0A2M9JUH1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CG723_17480</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000005">
        <property type="protein sequence ID" value="PJN10478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN10478">
        <property type="protein sequence ID" value="PJN10478"/>
        <property type="gene ID" value="CG723_17480"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PJN10478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="319" mass="34459" checksum="02CA2D4C3EAF61CE" modified="2018-04-25" version="1">MRSNYATLKAELVKHLSPVIVVQNDAKGGRFTLVTANGQESVNPVAETFELAKSIAHVPLGCFSVIASYLADKIPNLPNANRIDPHDLLLVAFNDDKSTAWIEPLQAYAVTLTTARKNLPAAGLPAALTTSCGNILDAALKFINASVTAKVFDMKSFEDFSGSVYPDIRVNMEHAAQAQIKGVQDTMKTWRAKVGEAAWADLYCVVLSQWTTSVLNQNTIIIKDCMNAAKVATHLIDLPGLETPKDPIFTALDNLARIVQDNIAAEMVFPKDTKVADALKGKEDLLSDEILIQLGGTAATTQTSPTYNTLSEGMCPVRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JUL4</accession>
    <name>A0A2M9JUL4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CG723_19085</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CB01635</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000005">
        <property type="protein sequence ID" value="PJN10518.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN10518">
        <property type="protein sequence ID" value="PJN10518"/>
        <property type="gene ID" value="CG723_19085"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="88"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="119"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="158"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="199"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="257"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="84"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PJN10518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="291" mass="31948" checksum="F5C746C60585F70D" modified="2018-04-25" version="1">MRPRTLISPAQLGRRRGKVVYWVVFALVTVLFTLVFLGPMYWMVSGGLKTTQEFVKSPPTLVPTSVHPGNYGDAWRVMDLAKLLGNTLYYAFGALAFQLVLDVAAAYSLSKLRPLFGNVILGMMLATLMIPATVLVVPQYLTVLDVPIFERNLLNSPWVIWLPSVTNAFNIFLLKRFFDSIPQELLDAASIDGASALRTLRSVVLPISRPILGVVSIFAVVGVWKDFLWPMLTLPDPGKQTLNVGIYSLASGVPENWLIAALTIASLPTLILFLLFQRNIMSGLTAGGLKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JUN6</accession>
    <name>A0A2M9JUN6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Bi-functional transferase/deacetylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_15010</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000004">
        <property type="protein sequence ID" value="PJN10532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN10532">
        <property type="protein sequence ID" value="PJN10532"/>
        <property type="gene ID" value="CG723_15010"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002509">
        <property type="entry name" value="NODB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01522">
        <property type="entry name" value="Polysacc_deac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="SSF88713"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51677">
        <property type="entry name" value="NODB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="312"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="602"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="634"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="domain" description="NodB homology" evidence="2">
        <location>
            <begin position="86"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN10532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="725" mass="80540" checksum="B3F897422A71CB49" modified="2018-04-25" version="1">MSSRPRSNRRAPRRRRLPMRYLLPSLLLVALLAMLMLRGYVHSEILADHRIQPPAATDQVPEKILEGGPVIDTRGGRETGMSVPDHRLVLTFDDGPDPQWTPKVLDVLKEHHAHGVFFVTGTMASRYPDLVKRMVDEGHEVGLHTFNHPDLSYQSKSRIDWELTQNQTALAGAAGIRTSLFRPPYSSFADAMDNKSWPVTKYIGSRGYITVVNNTDSEDWKRPGVDEIIRRATPKGGKGAIVLMHDSGGDRSQTVAALDRFLPQLQGQGYDFVNLTEALGAPSAHTPVHGLELAKGKAWIYAVDASDDVTDVLGVGLAVIGVLVFTRFGLMLLLSGAHARRVRRRGFSWGPPVTEPVSVLVPAFNEAKCIENTVRSLMSSEHPIEIIVIDDGSTDGTARIVENLRLPNVRVVRQHNAGKPAALNRGLANARFDLIVMMDGDTVFEPSTVRELVQPFGDQRVGAVAGNAKVGNKDSLIGAWQHIEYVMGFNLDRRMYDMLRCMPTIPGAVGAFRRSALERIGGMSDDTLAEDTDVTMALHRDGWRVVYAEKARAWTEAPESVQQLWSQRYRWSYGTMQAIWKHRRSVIESGPSGRFGRIGLPFVALFMVLAPLLAPLIDVFLLYGLVFGPTEKTIVAWLGVLAIQAVCAAYAFRLDRERMTHLISLPLQQVLYRQLMYVVLLQSWITALTGGRLRWQKLRRTGAVEAPGAIPRQRASRGNDRRPVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-09-29" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JUP9</accession>
    <name>A0A2M9JUP9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">(2Fe-2S)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CG723_15115</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000004">
        <property type="protein sequence ID" value="PJN10552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN10552">
        <property type="protein sequence ID" value="PJN10552"/>
        <property type="gene ID" value="CG723_15115"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002888">
        <property type="entry name" value="2Fe-2S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036884">
        <property type="entry name" value="2Fe-2S-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036010">
        <property type="entry name" value="2Fe-2S_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001041">
        <property type="entry name" value="2Fe-2S_ferredoxin-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006058">
        <property type="entry name" value="2Fe2S_fd_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01799">
        <property type="entry name" value="Fer2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47741">
        <property type="entry name" value="SSF47741"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54292">
        <property type="entry name" value="SSF54292"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00197">
        <property type="entry name" value="2FE2S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51085">
        <property type="entry name" value="2FE2S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="2Fe-2S ferredoxin-type" evidence="3">
        <location>
            <begin position="321"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="110"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="199"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="261"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="473"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="285"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="473"/>
            <end position="489"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PJN10552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="516" mass="52577" checksum="E7E89D2C9075DB5A" modified="2018-04-25" version="1">MTDEHNHGGHQGGGWEPLPQGDYDADATAFVQLPEGGLPDVPLAAPGHGHVPPQITIAPGGPAATDPAATGVWVLPPDVTGAQAAPTGAATGEVHWPEPAAPEAVPSYDHRAGATGQWNFSDAEQPPAHEHPVAEPAGQAGQAGQTGQWSIPVIAEGDLPDESGEFTTSSIAAQWGRTPPATLPGGAVAPWAAEEWAREPAGELEPEFAPEPAPAQGDADDVRDVHGARDIQGERDIHGEPEPVGDVADEAHAFADVAAESAEEPVRVPAAEASEVREAPEAPEVDEGPEVAEAPAPEDAVPDEPDPDAVVAPLHDDHPLASYVLRVNGTDRPVTGAWIGESLLYVLRERLGLAGAKDGCSQGECGACNVQVDGRLVASCLVPGATAAGSEVRTVEGLAADGQPSDVQRALAGRCAVQCGFCVPGMAMTVHDLLEGNPAPTELETRQALCGNLCRCSGYRGILDAVQQVVTEREASATSGTTATGSTSAGDAEGKARIPHQAGPSATEGIQDGGLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JV41</accession>
    <name>A0A2M9JV41_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_16350</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000004">
        <property type="protein sequence ID" value="PJN10756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN10756">
        <property type="protein sequence ID" value="PJN10756"/>
        <property type="gene ID" value="CG723_16350"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032816">
        <property type="entry name" value="SNARE_assoc"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09335">
        <property type="entry name" value="SNARE_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="60"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="145"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="174"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN10756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="210" mass="21169" checksum="35213400D8B3B969" modified="2018-04-25" version="1">MDFASLVSWADFTSGLSTRMSGAACWAYAILAVTTLPPLLPNAVLLITGGMLAARGEMSLVLVLLSVAGSALAGDVLIHRFGWFAGRRVRGGAAGRGRRGELFDWAAGRVQRGGIPFVVGVRFLPSGRLLGGLAAGAARYPARKFAIGAALAEVVWAACSVGVGYVGGAVSDDPVYSVATGLGLSVAVGAVAALAQRRATAPAANVSKGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JV64</accession>
    <name>A0A2M9JV64_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">VWFA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_16440</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000004">
        <property type="protein sequence ID" value="PJN10770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN10770">
        <property type="protein sequence ID" value="PJN10770"/>
        <property type="gene ID" value="CG723_16440"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041176">
        <property type="entry name" value="VWA_3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13519">
        <property type="entry name" value="VWA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18571">
        <property type="entry name" value="VWA_3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00327">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="SSF53300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50234">
        <property type="entry name" value="VWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VWFA" evidence="1">
        <location>
            <begin position="58"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN10770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="443" mass="46311" checksum="4E61299501B60FD1" modified="2018-04-25" version="1">MAKFSKPNAPQFSVDVYQNEFLPEGGREVNAIVTVTSTGGGAVAAPQFYAAGRGADAAVALMVDCSGSMDYPPTKMRNARDATAAAIDTLRDGVHFAVIGGTHVAKEVFPGGGRLAVADGQTRDQAKQALRKLSAGGGTAIGTWLRLADRLLSAADVSIRHGILLTDGRNEHESPEDLKAALDACTGRFTCDARGVGTDWEVKEVTGIASAMLGSADIVADPAGLAADFTRMMETAMGKEVADVALRLWTPLGAEIKFVKQVAPTVEELTDRRLEVGPRAGDYPTGSWGDESRDYHVCVQVPNAELGQEMLAGRVSLVIPGADGGVQNLAQGLVRAVWTDDMTASTSINPQVAHYTGQAELAQVIQQGLDARKAGDADGATAKLGRAVQLAAASGNADTAKLLSKVVDVVDAAEGTVRLKAKVAEADEMTLETRSTKTVRVKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JVD7</accession>
    <name>A0A2M9JVD7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Dihydrofolate synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CG723_16795</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CB01635</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000004">
        <property type="protein sequence ID" value="PJN10829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN10829">
        <property type="protein sequence ID" value="PJN10829"/>
        <property type="gene ID" value="CG723_16795"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004326">
        <property type="term" value="F:tetrahydrofolylpolyglutamate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001645">
        <property type="entry name" value="Folylpolyglutamate_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018109">
        <property type="entry name" value="Folylpolyglutamate_synth_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036565">
        <property type="entry name" value="Mur-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004101">
        <property type="entry name" value="Mur_ligase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036615">
        <property type="entry name" value="Mur_ligase_C_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013221">
        <property type="entry name" value="Mur_ligase_cen"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11136">
        <property type="entry name" value="PTHR11136"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02875">
        <property type="entry name" value="Mur_ligase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08245">
        <property type="entry name" value="Mur_ligase_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53244">
        <property type="entry name" value="SSF53244"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53623">
        <property type="entry name" value="SSF53623"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01499">
        <property type="entry name" value="folC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01012">
        <property type="entry name" value="FOLYLPOLYGLU_SYNT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mur_ligase_M" evidence="6">
        <location>
            <begin position="106"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="domain" description="Mur_ligase_C" evidence="5">
        <location>
            <begin position="362"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02875"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PJN10829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="503" mass="53117" checksum="3F5B7DD82851C38F" modified="2018-04-25" version="1">MSELPPRDSGESDGFDDIVDAETERDPDLALIEAGSRTLRTQGGAPQGDGVPARPQDPEVAEALREVETELAGRWGETKLEPSVSRIAALMDVLGDPQRAYPSIHITGTNGKTSTARMIEALLGAFELRTGRYTSPHVQSITERISLDGAPIDYERFIETYRDIAPYVEMVDQKEEFRLSFFEVLTGMAYAAFADAPVDAAVVEVGMGGSWDATNVIDASVAVVTPIDLDHTDRLGSTPGEIAQEKAGIIKQGATVIMAQQPVDAAQVLLKKAVDVDATVAREGLEFGVVSRQVAVGGQLLTLRGLGGEYDGIFLPLHGAHQAHNAAVALAAVEAFFGIGAQQARLLDLDTVRKAFAGATSPGRLEVVRRSPTVVLDAAHNPAGARVTAEAISEVFDFSRLVGVVGASGDKNVRGVLEAFEPIFAEVVVTQNSSHRAMGADELAAIAVEVFGDERVQVEPRLDDALEAAITLAEEEGEFSGGGVLVTGSVITVGEARLLLGKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JVW0</accession>
    <name>A0A2M9JVW0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_08560</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN11031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN11031">
        <property type="protein sequence ID" value="PJN11031"/>
        <property type="gene ID" value="CG723_08560"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN11031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="58" mass="6431" checksum="C55D6B4596DA8486" modified="2018-04-25" version="1">MAQALTKYDPQHKAPKNNFSARPIPKEDNGAGGRSIADFYRLNRIIDGPNDGYIIKVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JVY8</accession>
    <name>A0A2M9JVY8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_08520</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN11024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN11024">
        <property type="protein sequence ID" value="PJN11024"/>
        <property type="gene ID" value="CG723_08520"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="29"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN11024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="73" mass="7807" checksum="BADECDE612021BFE" modified="2018-04-25" version="1">MGLGGCILLIGAGAILTFGTDWQMRSVNLDVVGAIMMIVGVIGVLAFTSIAKRRRVVVPPSAPLIDEERDRRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JW55</accession>
    <name>A0A2M9JW55_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Serine/threonine protein phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_09150</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN11121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN11121">
        <property type="protein sequence ID" value="PJN11121"/>
        <property type="gene ID" value="CG723_09150"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07228">
        <property type="entry name" value="SpoIIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00331">
        <property type="entry name" value="PP2C_SIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="36"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="77"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="domain" description="PPM-type phosphatase" evidence="2">
        <location>
            <begin position="129"/>
            <end position="359"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN11121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="362" mass="38553" checksum="F1DBC668500184F8" modified="2018-04-25" version="1">MVQNKAQWIPAGVIVLAVVIDLVTPTQVTSAPLIMAAPVAAAPLLSLPGIIWVGLASMAVHAGLAWVDGTFGWHRGLANQFTLLAVTLLAIFINRTLKSQDARTRRAQRVAAVAQRAVLPRPPARLGDLHIAARYVPAEDEAMIGGDLYVVQDTPYGTRVLVGDVRGKGLGAVSAVCADLGAFRYAADEAEDLAQLVRSLEQALLREGGRRGGLEQEEGFTTALIAEFPANLSAVRIVNRGHPPPLLLDAQGSATVLEPTQEVPPLGMGVLGSWAAPVDTFPFPPGATLLCYTDGITESRDAEGTFYDAAARLPVLLRHRARSGEHPTPAQVLDMLIRDVRRHTGGRPQDDQALLALRRSAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JXJ8</accession>
    <name>A0A2M9JXJ8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">2-hydroxyacid dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CG723_11995</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CB01635</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN11603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN11603">
        <property type="protein sequence ID" value="PJN11603"/>
        <property type="gene ID" value="CG723_11995"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003714">
        <property type="term" value="F:transcription corepressor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05299">
        <property type="entry name" value="CtBP_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043322">
        <property type="entry name" value="CtBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006139">
        <property type="entry name" value="D-isomer_2_OHA_DH_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029753">
        <property type="entry name" value="D-isomer_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006140">
        <property type="entry name" value="D-isomer_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00389">
        <property type="entry name" value="2-Hacid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02826">
        <property type="entry name" value="2-Hacid_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00670">
        <property type="entry name" value="D_2_HYDROXYACID_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00671">
        <property type="entry name" value="D_2_HYDROXYACID_DH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="2-Hacid_dh" evidence="4">
        <location>
            <begin position="18"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="domain" description="2-Hacid_dh_C" evidence="5">
        <location>
            <begin position="111"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PJN11603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="326" mass="34747" checksum="2D768185BE47628D" modified="2018-04-25" version="1">MGQPVVVFTDPEELDVEPGARLLRDAGFEVRVVGSRDPGRIAAAAHDAEALIVGYAPVDATLLDRLPTVRMLATMSAGYDMVDTAEARRRGLWVSNLPHAATEDVAVHALAATLSLVRHLPHADATVRTGGWNTEFGELPRRAGELTLGLVGFGRIARAVARMAAPVFGRVAAFDPHADPAGWPPEVDRLDLDELVSRADVLSLHTPLTPQTHGLADEALLARMRPGSFLVNVSRGELVDPDALLRALDSGHLAGAALDVFPVEPPPADDPLRTHPRIQLSPHSAFLSDASQRAYVCAPAENVIAWQRTGRPLTPVVDPTLEGAVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JXS5</accession>
    <name>A0A2M9JXS5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_12510</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN11683.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN11683">
        <property type="protein sequence ID" value="PJN11683"/>
        <property type="gene ID" value="CG723_12510"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025714">
        <property type="entry name" value="Methyltranfer_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13847">
        <property type="entry name" value="Methyltransf_31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Methyltranfer_dom" evidence="1">
        <location>
            <begin position="176"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN11683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="355" mass="38093" checksum="C1D8A2B52598A886" modified="2018-04-25" version="1">MTTGQAVDSERKEEFAGRMLQVVNDACLGYLCSLGHRTGLFDTMAPLPPSTSVQIAKAADLDERYVREWLGGLTVAGVVEYRPADGTYWLPPEHAASLTRAAGPENTASLLQDLALLGIVEDEVLDAFRKGGGVPYSSYPRFQELQAEETGRVYDVALVDTIVPLAPGLPERLRAGIDALDIGTGQGHAVNLLAQAFPRSRFRGVDISQKGIAAARAEAERLGLDNVRFDVVDTADLSGTYDLITAFDVIHDLARPARTLDAVAAALRDDGVFLMGDISASSNLEENIDHPLGPALYTFSVFYCMTVSLGEGGAGLGSVWGRQRALQMLADAGFGDIDVEQVEGDILNVYYVARK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-09-29" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JXU4</accession>
    <name>A0A2M9JXU4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CG723_12630</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN11703.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN11703">
        <property type="protein sequence ID" value="PJN11703"/>
        <property type="gene ID" value="CG723_12630"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PJN11703.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="180" mass="19318" checksum="E7A3A732E7F05174" modified="2018-04-25" version="1">MLLLGGRAGVGKTTVGWEVSALLRSMEVSHAVIEGDFMGQVHPAPQGDPHRAGVTEDNLTAVWGNFARRGYRRLIYTNTVSVLPETAGMFERAMGAGVRIVRVLLTASDATAGERLAARELGSELETELRGSARKARLLDERAPTDTVRVATDGRTVTDIAHEVLAATGWADRPPVTGWT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JXU6</accession>
    <name>A0A2M9JXU6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CG723_12410</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CB01635</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN11668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN11668">
        <property type="protein sequence ID" value="PJN11668"/>
        <property type="gene ID" value="CG723_12410"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="40"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="108"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="140"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="165"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="216"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="272"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="102"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PJN11668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="306" mass="33552" checksum="487C9E23E6F33496" modified="2018-04-25" version="1">MSVTEDVRATTAPDPGPVRRRRAPCVTDENGRRIRVWELVLRYALLLAVLAITVGPFLWQLSTSLKGTHEDIFSSPPKFLPGDPTLHNYERVADTIPVWDYAFNSLKVATANVVTNCVGSALAGYALARLRYRGRKIATLVFILAMLVPVESIVIAQFTTMRELGLNNTLVGVVLPGCIAAMNVLLMRNAFLNLPYEIEEAAFVDGANAWQRFLRIALPSVKGTLAVVAIFAFMGAWDDFLWPLIVLSDPAKFTLTIGLNYLHGTFANDERIVAAGTIIAVAPLIILFACLQRYFFRGVGEGAVKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JY19</accession>
    <name>A0A2M9JY19_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_12985</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN11762.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN11762">
        <property type="protein sequence ID" value="PJN11762"/>
        <property type="gene ID" value="CG723_12985"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="46"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN11762.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="191" mass="20972" checksum="EA2FA329F6FCB9AD" modified="2018-04-25" version="1">MDEPGTAYEIRYGWTAPAWVALAFALLIGAGFIPGAEPPGSDHVELILAPYVALIVPPATLRLTAARIGPNGITLGRLLFFREPEFHPWSEIVSVSLSDGARGPGRLRIPELTVRHHRRLAPRRGRTTSSALRELDAYLTAYVDPDFVEAFRGTTESARSMVLCRVDTARLERAVRAFAPQVHFFGDAGRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JYG2</accession>
    <name>A0A2M9JYG2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">TetR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_13970</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN11923.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN11923">
        <property type="protein sequence ID" value="PJN11923"/>
        <property type="gene ID" value="CG723_13970"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041678">
        <property type="entry name" value="TetR_C_16"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17920">
        <property type="entry name" value="TetR_C_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="13"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="36"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN11923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="191" mass="20614" checksum="F65FD8ADC4884D30" modified="2018-04-25" version="1">MSAEAAGPRRNSARTREALLRAATELFSERGYDRTTIREIGERAGVDPALIARYFGSKPLLYVEVLRAEHGDTAPDDLLTEPRLREVAERAERRGPVPLLRVAVQPLSDGAAQDATRAALRARLVDPLRARFAREGRDRPGLRADVLVAAVAGVLLARHSGAFEDLAEADVDEVVDVLLETFGGGGPAGDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JYH0</accession>
    <name>A0A2M9JYH0_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SBP_bac_5 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_13255</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN11807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN11807">
        <property type="protein sequence ID" value="PJN11807"/>
        <property type="gene ID" value="CG723_13255"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042597">
        <property type="term" value="C:periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030678">
        <property type="entry name" value="Peptide/Ni-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039424">
        <property type="entry name" value="SBP_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000914">
        <property type="entry name" value="SBP_5_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30290">
        <property type="entry name" value="PTHR30290"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00496">
        <property type="entry name" value="SBP_bac_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002741">
        <property type="entry name" value="MppA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014857728" description="SBP_bac_5 domain-containing protein" evidence="1">
        <location>
            <begin position="24"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="domain" description="SBP_bac_5" evidence="2">
        <location>
            <begin position="100"/>
            <end position="468"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN11807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="572" mass="61446" checksum="EBEDC52DC75B208E" modified="2018-04-25" version="1">MNRSTKAALALTVSAGLALTACGGPKPTPGDRAGAKADAYAPVTVGKGYTAKGGNINVLMSSDFQTLDPGNSNYVQTANVGQLYYRTLTMAKETAGRPPTIVPDLATDLGKASADGLTWTYTLKKGLKFEDGTPITSKAIKYGVERTYARDVYTQAPQELNSALADDGYKGPYAGGDFKAIDTPDDHTVVFHLKQPFAEFPALVSRSNTAPVPKAKDTKLDYTNHPVSSGPYKIKSYDRGRSMKLVRNDQWDPATDPNRPALPDTFTFSLSTAQATISQQLLADSDPTAITLDSNGGLQASDAAKLNDPKVKKRTAAGLLGCTDVLNFNTETVKDPDVRKAMALSIDRGSIQVQYGGARFGKVAQSYINPAQRGYVAQHTDLDPAGNPKLDEAKKLLKGKKVPKKLVYGYADTNARYKNVGTVLQQNLKKLGIDLQLRPIPAANYYTVLAGDQMPDIARSGWCGGADSGSVRTTVDPNVGPSLDGKTYGFSNIPRFHDPKIARDMYKLRGTNGTSEELGKKWATLFDRTMQAYPLVPLVRSYTSSVVGSKVRGAQMGYFFGAIDLSIVGAEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JYI5</accession>
    <name>A0A2M9JYI5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Sugar kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CG723_14095</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CB01635</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FGGY kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN11943.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN11943">
        <property type="protein sequence ID" value="PJN11943"/>
        <property type="gene ID" value="CG723_14095"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016773">
        <property type="term" value="F:phosphotransferase activity, alcohol group as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000577">
        <property type="entry name" value="Carb_kinase_FGGY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018485">
        <property type="entry name" value="Carb_kinase_FGGY_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018483">
        <property type="entry name" value="Carb_kinase_FGGY_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018484">
        <property type="entry name" value="Carb_kinase_FGGY_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02782">
        <property type="entry name" value="FGGY_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00370">
        <property type="entry name" value="FGGY_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000538">
        <property type="entry name" value="GlpK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00445">
        <property type="entry name" value="FGGY_KINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="FGGY_N" evidence="2">
        <location>
            <begin position="6"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="domain" description="FGGY_C" evidence="3">
        <location>
            <begin position="257"/>
            <end position="437"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU003733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PJN11943.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="492" mass="52624" checksum="B82709E4C9F5B255" modified="2018-04-25" version="1">MPQSAVIGVDIGTSSSKGVLVGLDGTVLHTAVREHAVDRPAPGHVEMDADIWWGEFVSLTRELTTAHDAEVIAVGVSGMGPCVLLADENDTPVRPAILYGVDTRSVPQIERLESELGAEEIAHRCGSRLTTQAAGAKVAWIAEQEPELYARARRLYMPSSWLVRKLTGAYVLDHHSASQSTPLYGTLTRDWYTPWSDLIAPGIELPELRWSGEAAGTVTAEAARLTGLPTGIPVTTGTIDAWAEALSVGAHGIGDLMLMYGTTMFLVHTVPGLLRDPSLWSTVGALPDTRNLAGGMATSGAVTSWLRDLFGSDDYRQLLRLAEESGPGAGGLLMLPYFAGERTPITDPRARGVIAGLTLSHTRGDLYRAALEGTAYGVRHNVEAIEAAGGDIRRVVAVGGGTQGRLWTQIVSDVTGRAQEVRTTSIGASYGGALLAAQLVADARIDAWNPVQEVVTPRPEMTSRYDELYALYRELYPASSHVVHALADFQSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JYP3</accession>
    <name>A0A2M9JYP3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">TetR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_14430</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN12002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN12002">
        <property type="protein sequence ID" value="PJN12002"/>
        <property type="gene ID" value="CG723_14430"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023772">
        <property type="entry name" value="DNA-bd_HTH_TetR-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01081">
        <property type="entry name" value="HTH_TETR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="9"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="32"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN12002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="190" mass="21536" checksum="DFCF11DC5AD320E4" modified="2018-04-25" version="1">MNLRERKKLATWRAIRTAALQLFEEQGYETTTVEQIVAAANVSRATFFNYFAGKEAVVFDQDSEERGAWQTLMDDRPADEPLWESLTTILTGFLESLRDRMPLQRRLKAQSPALAQSGQNFGEAFFTELRKWVASRATPADELTATLQVNLALAAAITAYDTWPDDEPFDGFLQRLEQCLRDGRPVVATR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JYT8</accession>
    <name>A0A2M9JYT8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CG723_14515</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CB01635</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN12018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN12018">
        <property type="protein sequence ID" value="PJN12018"/>
        <property type="gene ID" value="CG723_14515"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="20"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="86"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="130"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="203"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="246"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="82"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PJN12018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="283" mass="29381" checksum="6FC2B418C3D6972C" modified="2018-04-25" version="1">MSTQTLAPGGLHLTKNRRPFGVVVAGGVMTLVVLAAVLAPLLAPYAPDAIDLSASLVGTSGDHLLGTDSSGQDLLSRVLYGARTSLIAPILLLAIAALLGVTLGTLAAWRGGWVDTLVSRLTDVMYAFPGLLFTVLIIAVFGSGMTTSVLALGLAYTPTVAKYTRSVALAERRKPYIDAYRVLGMGGARICARFLVPNLGRSVVGYLVVLFGEALMSLATLSYLGFGAQPPSSDWGLMVQEGQAAVVQGALLPALVPGFAIALVVVSFNVVGVWAADRLGNRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JZ13</accession>
    <name>A0A2M9JZ13_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HATPase_c domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_09250</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN12109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN12109">
        <property type="protein sequence ID" value="PJN12109"/>
        <property type="gene ID" value="CG723_09250"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13581">
        <property type="entry name" value="HATPase_c_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HATPase_c" evidence="2">
        <location>
            <begin position="2"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="71"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="71"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN12109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="125" mass="13745" checksum="B275EC8B4934C14C" modified="2018-04-25" version="1">MPALRTSARSARDTVRDRLRAWKVPGDTCCDAVLLVSELTTNAVLHTDSGHVLCGLTLTGDERCLRIELHDDGRTPVRPPEHHAGPEEENGRGLFLVQQLADRWGSARSTRAEGKVVWAELTAHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JZ16</accession>
    <name>A0A2M9JZ16_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ABC transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_09345</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN12111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN12111">
        <property type="protein sequence ID" value="PJN12111"/>
        <property type="gene ID" value="CG723_09345"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015168">
        <property type="entry name" value="SsuA/THI5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09084">
        <property type="entry name" value="NMT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014896387" evidence="1">
        <location>
            <begin position="22"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="domain" description="NMT1" evidence="2">
        <location>
            <begin position="86"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN12111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="343" mass="37211" checksum="32124E757E3169D5" modified="2018-04-25" version="1">MTAVAVSLLLTACVNNTQSTATGENVAAKKIPAKVSADTSLTVGAPDLKVALELSGQIHKLPFKVKWANISGGPQCSEAFRADALDICSAAEIPSINAHWTGLDTKLVAAKFRKDPTAYPIYELGIAPGAHIKTLADLRGKKIAYSPGQAQGALVLRILKKAGLTQQDVDLVELASTGDVYPTALGNRQVDAAPIADVNIKRYLTKYGRDGGTTIKHGLRDDPGHLWALTDSVSNPQKSAAVRELIKFWARAQIWIDEHPKQWIDGYYVKDQGLSSEDGEYLVERSGRPDFPADWTGAIERQQQTVDLLAKEQKHKAFDAGTLFDRRYERVAADAVAGERKTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JZ33</accession>
    <name>A0A2M9JZ33_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NmrA family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_09485</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN12118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN12118">
        <property type="protein sequence ID" value="PJN12118"/>
        <property type="gene ID" value="CG723_09485"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016040">
        <property type="entry name" value="NAD(P)-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13460">
        <property type="entry name" value="NAD_binding_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD(P)-bd_dom" evidence="1">
        <location>
            <begin position="8"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN12118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="288" mass="31127" checksum="650193F321178F23" modified="2018-04-25" version="1">MQPVLVTGATGRIGRAVIAELLAAGVPVRALTRNPAAAGLPGHVEVVAGDFTEPESLDPALQGVRSVFLLWTAPPATAEAVIERLASRARRVVFLSSPHRTDHPFFQQPNPMARMHAEIERLITAAGLESTFIRPGMFTSNARLWWAPTIRDGGVVRWPYGAAETAPIDERDLAAVAARTLYEEGHAGGDYVLTGPESLSQAEQVGVIGSVLGQQIPFEELSPEEFRRATEDIWPGPVVEMLLDAWGATIGRPAYVTSTVADVLGVPARTFRQWVSDHADAFRERPAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JZU0</accession>
    <name>A0A2M9JZU0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Aldolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_04665</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the KHG/KDPG aldolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000002">
        <property type="protein sequence ID" value="PJN12350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN12350">
        <property type="protein sequence ID" value="PJN12350"/>
        <property type="gene ID" value="CG723_04665"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00452">
        <property type="entry name" value="KDPG_aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000887">
        <property type="entry name" value="Aldlse_KDPG_KHG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30246">
        <property type="entry name" value="PTHR30246"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01081">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN12350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="206" mass="20663" checksum="C18582CF9C07538F" modified="2018-04-25" version="1">MDFTTALRAERLVAIVRGSDADASFRTVMALAEAGIPLVEVSLSGRDALDVIRRARAELGDDVWLGAGTVLTAEDAREAAAAGANLIVTPGLGAGVDESLRQGLPVLAGVLTPTDVIAAEASRATALKIFPASATGGPSYLKALRGPFPRTPFVPVGGVDAAAATAYLEAGAIAVGVGSPLIGDAADGGDLGQLRKRAAEFKAVCG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K055</accession>
    <name>A0A2M9K055_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CG723_05605</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000002">
        <property type="protein sequence ID" value="PJN12509.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN12509">
        <property type="protein sequence ID" value="PJN12509"/>
        <property type="gene ID" value="CG723_05605"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PJN12509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="39" mass="4553" checksum="ED371C4357E05C3F" modified="2018-04-25" version="1">MASFHNTATGRHDLEPFWPSRQHHDFDRVCCRAENAQAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-05-25" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K068</accession>
    <name>A0A2M9K068_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CG723_05600</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000002">
        <property type="protein sequence ID" value="PJN12508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN12508">
        <property type="protein sequence ID" value="PJN12508"/>
        <property type="gene ID" value="CG723_05600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00383">
        <property type="entry name" value="trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OmpR/PhoB-type" evidence="3">
        <location>
            <begin position="102"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="1">
        <location>
            <begin position="102"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="77"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PJN12508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="205" mass="22352" checksum="88D1F8ACF5F825D1" modified="2018-04-25" version="1">MANTRSFTTASSATSAPSPAVSGRHRLRAVDRDEVVDVTDFLPPGATWLPAPPHTLPTLPGRPPMIGYLVLVPADQQPLLPVPDEPGRRPEAAPQDSDTAITATATATDALVRIDGTQRTAQVNGRQLDLTYLEFELLAHLVAHPHRVHTRDQLVTTVWGYGHVGDGRTVDVHVARLRRKLGAEHRQVIQTVRRVGYKYAPPAAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K093</accession>
    <name>A0A2M9K093_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 13">Dihydrolipoyl dehydrogenase</fullName>
            <ecNumber evidence="3 13">1.8.1.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">lpdA</name>
        <name evidence="16" type="ORF">CG723_05760</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">CB01635</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 13">
            <text>(R)-N(6)-dihydrolipoyl-L-lysyl-[protein] + NAD(+) = (R)-N(6)-lipoyl-L-lysyl-[protein] + H(+) + NADH</text>
            <dbReference type="Rhea" id="RHEA:15045"/>
            <dbReference type="Rhea" id="RHEA-COMP:10474"/>
            <dbReference type="Rhea" id="RHEA-COMP:10475"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:83099"/>
            <dbReference type="ChEBI" id="CHEBI:83100"/>
            <dbReference type="EC" id="1.8.1.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11 13">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="11 13">Binds 1 FAD per subunit.</text>
    </comment>
    <comment type="miscellaneous">
        <text evidence="13">The active site is a redox-active disulfide bond.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.8.1.4" evidence="3 13"/>
    <dbReference type="EMBL" id="NNBL01000002">
        <property type="protein sequence ID" value="PJN12538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN12538">
        <property type="protein sequence ID" value="PJN12538"/>
        <property type="gene ID" value="CG723_05760"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004148">
        <property type="term" value="F:dihydrolipoyl dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045454">
        <property type="term" value="P:cell redox homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016156">
        <property type="entry name" value="FAD/NAD-linked_Rdtase_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006258">
        <property type="entry name" value="Lipoamide_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001100">
        <property type="entry name" value="Pyr_nuc-diS_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004099">
        <property type="entry name" value="Pyr_nucl-diS_OxRdtase_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012999">
        <property type="entry name" value="Pyr_OxRdtase_I_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02852">
        <property type="entry name" value="Pyr_redox_dim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000350">
        <property type="entry name" value="Mercury_reductase_MerA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55424">
        <property type="entry name" value="SSF55424"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01350">
        <property type="entry name" value="lipoamide_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00076">
        <property type="entry name" value="PYRIDINE_REDOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5 11 13" id="KW-0274">FAD</keyword>
    <keyword evidence="4 13" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7 11 13" id="KW-0520">NAD</keyword>
    <keyword evidence="11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9 13" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyr_redox_2" evidence="15">
        <location>
            <begin position="9"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="domain" description="Pyr_redox_dim" evidence="14">
        <location>
            <begin position="341"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="10">
        <location>
            <position position="439"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="55"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="118"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="142"/>
            <end position="144"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="179"/>
            <end position="186"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="202"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="266"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="306"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="disulfide bond" description="Redox-active" evidence="12">
        <location>
            <begin position="46"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012608"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000350-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR000350-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR000350-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU003692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF02852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="PJN12538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="462" mass="48765" checksum="066F4AD094A1DF7F" modified="2018-04-25" version="1">MANDASTVFDLVILGGGSGGYAAALRGAQLGLDVALIEKNKLGGTCLHNGCIPTKALLHAGEIADQAREADQFGVKASFEGIDIAGVHKYKDDVISGLYKGLQGLVASRKVTYIEGEGRLSSPTSVDVNGQRVQGRHVLLATGSVPKSLPGLEIDGNRIISSDHALKLDRVPQSAIILGGGVIGVEFASAWKSFGTDVTVVEGLKHLVPVEDENSSKLLERAFRKRGIKFNLGTFFEKAEYTQDGVRVTLADGKTFEAEVLLVAIGRGPVSAGLGYEEQGVAMDRGYVLVDEYMQTNVPTVSAVGDLVPTLQLAHVGFAEGILVAERLAGLKTVPIDYDGVPKVTYCHPEVASVGITEAKAKEIYGADKVVALKYNLAGNGKSKILKTAGEIKLVQVKDGAVVGVHMVGDRMGEQVGEAQLIYNWEALPAEVAQLIHAHPTQNEALGEAHLALAGKPLHSHD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K0A9</accession>
    <name>A0A2M9K0A9_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 3">Methionine aminopeptidase</fullName>
            <shortName evidence="2">MAP</shortName>
            <shortName evidence="2">MetAP</shortName>
            <ecNumber evidence="2 3">3.4.11.18</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Peptidase M</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2 6" type="primary">map</name>
        <name evidence="6" type="ORF">CG723_05310</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CB01635</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 2">Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). Requires deformylation of the N(alpha)-formylated initiator methionine before it can be hydrolyzed.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 3">
            <text>Release of N-terminal amino acids, preferentially methionine, from peptides and arylamides.</text>
            <dbReference type="EC" id="3.4.11.18"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 3">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
        <cofactor evidence="2 3">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <cofactor evidence="2 3">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <cofactor evidence="2 3">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <text evidence="2 3">Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe(2+)-metalloproteases under physiological conditions, and the catalytically relevant metal-binding site has been assigned to the histidine-containing high-affinity site.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase M24A family. Methionine aminopeptidase type 1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.11.18" evidence="2 3"/>
    <dbReference type="EMBL" id="NNBL01000002">
        <property type="protein sequence ID" value="PJN12457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN12457">
        <property type="protein sequence ID" value="PJN12457"/>
        <property type="gene ID" value="CG723_05310"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046914">
        <property type="term" value="F:transition metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070084">
        <property type="term" value="P:protein initiator methionine removal"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01086">
        <property type="entry name" value="MetAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01974">
        <property type="entry name" value="MetAP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036005">
        <property type="entry name" value="Creatinase/aminopeptidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000994">
        <property type="entry name" value="Pept_M24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001714">
        <property type="entry name" value="Pept_M24_MAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002467">
        <property type="entry name" value="Pept_M24A_MAP1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00557">
        <property type="entry name" value="Peptidase_M24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00599">
        <property type="entry name" value="MAPEPTIDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55920">
        <property type="entry name" value="SSF55920"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00500">
        <property type="entry name" value="met_pdase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00680">
        <property type="entry name" value="MAP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 6" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 3" id="KW-0645">Protease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase_M24" evidence="5">
        <location>
            <begin position="48"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="114"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="131"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="142"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="205"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="212"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="238"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002521"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PJN12457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="285" mass="31268" checksum="1E6BA15EF8C65F59" modified="2018-04-25" version="1">MSGQSLLVPGELSPTRSVPGNIRRPEYVGKPAPTPYKGPELQTPETVEAMRLAGRIAARAMEEAAKAIAPGVTTDELDRIAHEYMVDHGAYPSTLGYRNFPKSLCTSVNEVICHGIPDSTVLKDGDIINLDVTAYIGGVHGDNNATYLVGDVDEESRLLVERTRESLNRAIKAVRPGRQINIIGRVIESYAKRFGYGVVRDFTGHGINSSFHSGLIIPHYDSPHATTVIQPGMTFTIEPMLTLGTHEYDMWDDGWTVVTKDRKRTAQFEHTLVVTETGAEILTLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K0E3</accession>
    <name>A0A2M9K0E3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">N-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_05535</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000002">
        <property type="protein sequence ID" value="PJN12497.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN12497">
        <property type="protein sequence ID" value="PJN12497"/>
        <property type="gene ID" value="CG723_05535"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="5"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN12497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="172" mass="18989" checksum="05697494744F67CE" modified="2018-04-25" version="1">MTPRLTFRRAADGPDDLAALVALYDGAARWMVEQGIDQWQPGEKTEDHFRLRIKEGEVWFAGDALSEGVGAYELWWDDEPAWGARPPEAGYVHRLMVRRGAPPGTGRALLAHAEERVAAAGRDLCRLDCVSTNPRLRAYYERAGYAVVGEQPFKAGAGGSKYAVTLMEKRVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K0N9</accession>
    <name>A0A2M9K0N9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CG723_06535</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CB01635</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000002">
        <property type="protein sequence ID" value="PJN12676.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN12676">
        <property type="protein sequence ID" value="PJN12676"/>
        <property type="gene ID" value="CG723_06535"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005384">
        <property type="term" value="F:manganese ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030026">
        <property type="term" value="P:cellular manganese ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008217">
        <property type="entry name" value="Ccc1_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31851">
        <property type="entry name" value="PTHR31851"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01988">
        <property type="entry name" value="VIT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="160"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="187"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="221"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PJN12676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="243" mass="25468" checksum="D34994E25C14DF52" modified="2018-04-25" version="1">MAIIETEATLHDAHRDNHTHRDVNGGWLRPAVFGAMDGLVSNLALMTGVAGGAVSQQTIIITGLSGLAAGAFSMAAGEYTSVASQRELVEAELDVERRELRKHPADEERELADLYMSRGVEPDLAREVARQLSKDPEQALEIHAREELGIDPGDLPSPTVAAVSSFGSFALGALLPLLPYLLGASALWPAVLLALVGLFACGAIVAKVTARSWWFSGVRQLALGGAAAGVTYLLGSLFGTAVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K0V4</accession>
    <name>A0A2M9K0V4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Dipeptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_06955</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000002">
        <property type="protein sequence ID" value="PJN12744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN12744">
        <property type="protein sequence ID" value="PJN12744"/>
        <property type="gene ID" value="CG723_06955"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002933">
        <property type="entry name" value="Peptidase_M20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011650">
        <property type="entry name" value="Peptidase_M20_dimer"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07687">
        <property type="entry name" value="M20_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01546">
        <property type="entry name" value="Peptidase_M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="M20_dimer" evidence="1">
        <location>
            <begin position="193"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN12744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="453" mass="47990" checksum="376371CA0255174B" modified="2018-04-25" version="1">MDARDLQAEVDGLMGGLRADLERLAAIPSIAFPGFPAEPVREAHDLLVGLLRDAGVERVERIDLPDTAPVIFGEIPPPTPDAPTVLLYSHYDVQPPGDEKLWKSPPFDPTPVEGGLRARGIADDKSNVIAHLGMLRAFKGRPPVGVKIVFEGQEEYGSPFDDYPPTDPERFACDAMVIADLGNLRPGTPTLTTGLRGASEVVVEVRTLEEPRHSGEFGGAAPDALLVLLKALATLHDVHGDVAVEGLRRDEWTGTSYTEDEFRSLAGVEDGLPLIGSGTLGERLWSGPAITVIGLDAPAVEHAASAVVPYARAKLNLRFHPLQDPKEAQARLVDHLSTLKPFGIPLAITPGDTGPGYEAATGGPAYRAALTALKEAWGSDASYVATGGSIPLVNGLAKAAPGAEVLLFGAQDSMCNLHAPNERVLFSELRSTVVAMCAFVREYAADFRAGTAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K136</accession>
    <name>A0A2M9K136_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">1-aminocyclopropane-1-carboxylate deaminase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CG723_07470</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CB01635</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>1-aminocyclopropane-1-carboxylate + H2O = 2-oxobutanoate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:16933"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16763"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:58360"/>
            <dbReference type="EC" id="3.5.99.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ACC deaminase/D-cysteine desulfhydrase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000002">
        <property type="protein sequence ID" value="PJN12842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN12842">
        <property type="protein sequence ID" value="PJN12842"/>
        <property type="gene ID" value="CG723_07470"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008660">
        <property type="term" value="F:1-aminocyclopropane-1-carboxylate deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901607">
        <property type="term" value="P:alpha-amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009310">
        <property type="term" value="P:amine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027278">
        <property type="entry name" value="ACCD_DCysDesulf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005965">
        <property type="entry name" value="ACP_carboxylate_deaminase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="PLP-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="Trypto_synt_PLP_dependent"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43780">
        <property type="entry name" value="PTHR43780"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006278">
        <property type="entry name" value="ACCD_DCysDesulf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="SSF53686"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01274">
        <property type="entry name" value="ACC_deam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 7" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PALP" evidence="8">
        <location>
            <begin position="13"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="6">
        <location>
            <position position="77"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="7">
        <location>
            <position position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008639"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR006278-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR006278-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PJN12842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="339" mass="36267" checksum="67C7C1DF5A7A3ECE" modified="2018-04-25" version="1">MTIDAYERYPLLFGPSPVHPLDRLTAHLGGASLWAKREDCNSGIAYGGNKTRKLEYLVADALAQGCDTLVSIGGVQSNHTRQVAAVAARAGLKCVLVQESWVEWPDSVYDKVGNILISRLAGAEVRLVRAGFGIGVKESWEQAVREVEEAGGRPYAIPAGCSEHRLGGLGFAQWVYELAEQEEELGVFFDTVVVCSVTGSTQAGMIAGCAALVESGGRPRRILGVDASAEPDRTREQILRIARGTAGLVGVRRELTEDDVELDERHHAGTYGVPDEATLDAMRLAARTEGMVTDPVYEGKSMAGMIDLVARGEIGPDATVLYAHLGGQPALNAYSALFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K181</accession>
    <name>A0A2M9K181_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">GRAM_POS_ANCHORING domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CG723_07665</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000002">
        <property type="protein sequence ID" value="PJN12879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN12879">
        <property type="protein sequence ID" value="PJN12879"/>
        <property type="gene ID" value="CG723_07665"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019931">
        <property type="entry name" value="LPXTG_anchor"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50847">
        <property type="entry name" value="GRAM_POS_ANCHORING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0134">Cell wall</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0572">Peptidoglycan-anchor</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0964">Secreted</keyword>
    <keyword evidence="2 6" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014980732" description="GRAM_POS_ANCHORING domain-containing protein" evidence="6">
        <location>
            <begin position="38"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="286"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="domain" description="GRAM_POS_ANCHORING" evidence="7">
        <location>
            <begin position="275"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="238"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PJN12879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="310" mass="30963" checksum="06C4064BD2A6D702" modified="2018-04-25" version="1">MPSTTFRTPGRRLAASAAATALAVAPALLATAGTAHATGGHGGRSSAVVLRTGLDVSLLNKTVNVPLTATLNEVQAPASAEKTALTVKLDGVDRGRPFNVLRADVATAKATVDDHKAEGYSNLAHAKVHIPGLPLLSLIEVGQVTSKAVCETGKRPVAESNVLGAVTVLGKKVTLSAGGTTEVKVPGVGEVRLDLSKTHTTSRTAAASALELKVSVNPLKLNVAEVEGTVTLAGATCETPEAAPSQKPPAKSADDVKPQGGAAEPIAKPAAKADLAETGGNSMTPYIAGGAIVLLVAGGGAVAVARRGRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K1A9</accession>
    <name>A0A2M9K1A9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Lysoplasmalogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CG723_07880</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CB01635</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TMEM86 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000002">
        <property type="protein sequence ID" value="PJN12915.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN12915">
        <property type="protein sequence ID" value="PJN12915"/>
        <property type="gene ID" value="CG723_07880"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012506">
        <property type="entry name" value="YhhN"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31885">
        <property type="entry name" value="PTHR31885"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07947">
        <property type="entry name" value="YhhN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="91"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="122"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="147"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="171"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="201"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PJN12915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="241" mass="25016" checksum="07F6A365E2D3B646" modified="2018-04-25" version="1">MTPTPAPAPGEAPAPARERAARLLLAAFAVATAVDLIALLAGTDLVHTVAKPLLMPLLAASVVVRGGPRLLTAALLFGWGGDLLLLFDADVAFLAGMGSFAAGHVCYLVLFKRAGTPRARGGLLAAAYGIALVTTVALLWPDLPADMRGPVAGYSLLLTAMAYGSSRMGRAAGWGGALFLLSDTLIATGVADWPQLPRPDFWVMLTYVAAQYLLARGVLGHPLDARATPAAAYREKRTTTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K223</accession>
    <name>A0A2M9K223_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CG723_00830</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000001">
        <property type="protein sequence ID" value="PJN13171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN13171">
        <property type="protein sequence ID" value="PJN13171"/>
        <property type="gene ID" value="CG723_00830"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-binding" evidence="2">
        <location>
            <begin position="17"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding_C" evidence="3">
        <location>
            <begin position="422"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="494"/>
            <end position="559"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PJN13171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="559" mass="59875" checksum="77D197D1A77057E8" modified="2018-04-25" version="1">MTARSSPYVRRILDALERDPSRAVLHRPDGTVAAGELSDSVHGTTALLYDRGVGRGDTVAVLTGPNHPLMLSARYAVHLLGATSVYVRSMNPRTDTETFSLGTQTQLLRDLGALLLLVDEESAERGRWLAHRLPGLTVLPIPRGAPARALDPGRLPPPRPDALAVVDFTSGSTGRPKMVAQQFGTREELVDRLAHGLDPRGPATLLSVTPISHTTAPMADAVLSGGGTVVLHDGFDPDDVLRSFAQQHVTDVYLAVPHLYRLLDHPGIDATDLSALRRITYSGTPAAPGRVERAVRLFGDVLIQVYGTTEAGGISSLNPLDHREPELLGSVGRPFPWVRLEIRTPGGGPQVERGVTGELWVNSPTVTAGYLDDDELTGATLRDGWLRTGDLGHWDRYGYLRLDGRVGDVIKHGGLKLDPTAIEGALLQHPQVRQATVFGVRDDDYVEQVHAAVELHSGAARTSCDLRGYVAATLTPEHTPVRISVWPQLPLTPSGKPDRAYLRRVSSTPERSGPKASAAAPAPATSSPRGATARDGPVRVRGTGAPPDHAIPRTRKGVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K262</accession>
    <name>A0A2M9K262_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Glyco_trans_2-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_01125</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000001">
        <property type="protein sequence ID" value="PJN13222.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN13222">
        <property type="protein sequence ID" value="PJN13222"/>
        <property type="gene ID" value="CG723_01125"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glyco_trans_2-like" evidence="1">
        <location>
            <begin position="9"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN13222.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="491" mass="54344" checksum="F7F1773A931F254D" modified="2018-04-25" version="1">MSQASRDVTVVVPFRDVQNFFSEFLASVAAQTAFSRAHVILVDNGSTDHSVGIASEFAGLYPNVDLVAQPHGRAGDARNMGMDMAATPYIVFWDADDIVPERSLEVLRNTIIKTRATVVVGREKHVPKPVKAPWHKYFGKNVKTVDSVVDIPDLIHSASCWNKIFDLDLLRSQGIRFGTGTAFEDAYVSIPALLLAERISLVDAPVYEYRRRGDGTSVMDTLWDLPQNYADQLVMLEYLAAMREQLTPYQQETLERFLIRSMQGFLLRAPRILSESECRQLFERCRALYWGITSESFVRSTNDTRHRLPYLALHFGDFDLFHRPASVLGPVYGREADLYVDYPGTSWALPLTKVTSVPARIEGIAAGDGGTAVVHGRFSVNGIPDELLEKIELQVWFERSGKTLPAVNHGQLHDRTGQGGAAFSVTLDPREFPAGAFPVRLVVCTRGRNVSRPCGVSPGVVQQPPVAGFHGLTRIATEGSDARLVIESTQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K289</accession>
    <name>A0A2M9K289_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CG723_01225</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000001">
        <property type="protein sequence ID" value="PJN13241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN13241">
        <property type="protein sequence ID" value="PJN13241"/>
        <property type="gene ID" value="CG723_01225"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010644">
        <property type="entry name" value="ChdC/CLD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36843">
        <property type="entry name" value="PTHR36843"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06778">
        <property type="entry name" value="Chlor_dismutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0349">Heme</keyword>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PJN13241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="239" mass="27660" checksum="D415B131DB4A5A27" modified="2018-04-25" version="1">MSDDAPAKIPNAGKKAKDLNEVIRYTLWSVFKLRDVLPEDRAGYADEVQELFDQLAAKDVTVRGTYDVSGLRADADVMVWWHAETADQLQEAYNLFRRTKLGRALEPVWSNMALHRPAEFNRSHIPAFLADETPRNYVSVYPFVRSYDWYLLPDEDRRRMLADHGKMARGYPDVRANTVASFSLGDYEWLLAFEADELYRIVDLMRHLRASEARMHVREEVPFYTGRRKSVAELVEGLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-09-29" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K2B2</accession>
    <name>A0A2M9K2B2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Phosphate--nucleotide phosphotransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_01375</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000001">
        <property type="protein sequence ID" value="PJN13266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN13266">
        <property type="protein sequence ID" value="PJN13266"/>
        <property type="gene ID" value="CG723_01375"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016776">
        <property type="term" value="F:phosphotransferase activity, phosphate group as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006797">
        <property type="term" value="P:polyphosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022300">
        <property type="entry name" value="PPK2-rel_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022488">
        <property type="entry name" value="PPK2-related"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03976">
        <property type="entry name" value="PPK2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03709">
        <property type="entry name" value="PPK2_rel_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PPK2" evidence="2">
        <location>
            <begin position="85"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN13266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="327" mass="36058" checksum="7897A216824B74A6" modified="2018-04-25" version="1">MAKADKDTKRNGKGKGKGEPAKSAGKSRAKAGQAPGKPSGKSSGSKSPVALRELLRIPAGKPVNLASFDARATPAGPSGKTAGLEATARMGERLADLQERLWASGTAGDRRRVLLILQGMDTSGKGGTVKHVIGLFNPSGCRIKAFKAPTPEERGHPFLWRIMRALPEPGEIGIFDRSQYEDVLAARVRGLVPRRQAGGRYGQINRFEQSLAEDGVTVVKCFLHISYEEQRERLLERLDNPDKHWKFSMGDIEDRALWPAYQEAYEIALERCSTDDAPWYLVPADRKWYRNWAVSKLLLEHLEALDPTYPKADFDVAGAREQLLAQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K2E2</accession>
    <name>A0A2M9K2E2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_00975</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000001">
        <property type="protein sequence ID" value="PJN13197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN13197">
        <property type="protein sequence ID" value="PJN13197"/>
        <property type="gene ID" value="CG723_00975"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13581">
        <property type="entry name" value="HATPase_c_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HATPase_c" evidence="2">
        <location>
            <begin position="44"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="110"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN13197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="174" mass="17958" checksum="ED3585382824AA7A" modified="2018-04-25" version="1">MVESRTAPPLSAPVTPCQDTCTLNGPAVPTPPAPTSWRIALPHSAAAVPVARALVRTALTEIESPAADSDTAELLTAELVANAVEHTAGSGPIELVVELLPSGCQVEVHDGDPAPPGDLTLPGPAEEPDPWQEHGRGLLLIRTLSSSCGHRPTASGKAVWFTLPAIPAQRTSPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K2P0</accession>
    <name>A0A2M9K2P0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">AMP-dependent synthetase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_02090</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000001">
        <property type="protein sequence ID" value="PJN13389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN13389">
        <property type="protein sequence ID" value="PJN13389"/>
        <property type="gene ID" value="CG723_02090"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-binding" evidence="1">
        <location>
            <begin position="60"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding_C" evidence="2">
        <location>
            <begin position="466"/>
            <end position="543"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN13389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="567" mass="62568" checksum="523809D0C49FD151" modified="2018-04-25" version="1">MTTATSGTDPSPTEQFRTARDFLLRNADDYTAAYEGFAWPRPERFNWALDWFDAIADGNGKTALHIVEEDGREGRFTFDELRRRSNRVANWLRGQGVHAGDRVLLMLGNQVELWEIMLAAMKLRAVVIPATPLLGPADLRDRVDRGRARHVIVRPEDVEKFTEVPGAFTRTVVGASGTPGSGWLSYEEADDASETFEPDGVTSAEDPLLLYFTSGTTARPKLVEHTHVSYPVGHLATMFWIGLRPGDVHLNISSPGWAKHAWSNFFAPWNAEATVFLYNYTRFDAGRLLEVMERAGVTSFCAPPTVWRMLIQADLTQLATPPRAVVAAGEPLNPEVIQQVRRAWGVTIRDGFGQTETAVQVSNSPGQELKTGSMGRPSPGYKVELLDPVTGQPGAQEGEISLDLSERPVGLMAGYHGDPERTAEAMAGGYFRTGDIGSRDADGYLTYVGRSDDVFKASDYKISPFELESALLEHEAVAEAAVVPAPDELRLAVPKAYVVLAEGYEPGPGTAKLLFAHSRDALAPYKRVRRLEFAELPKTVSGKIRRIELRERTAQGSTAEYREEDFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K2Z4</accession>
    <name>A0A2M9K2Z4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">CoA ester lyase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CG723_02735</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CB01635</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000001">
        <property type="protein sequence ID" value="PJN13498.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN13498">
        <property type="protein sequence ID" value="PJN13498"/>
        <property type="gene ID" value="CG723_02735"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005000">
        <property type="entry name" value="Aldolase/citrate-lyase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011206">
        <property type="entry name" value="Citrate_lyase_beta/mcl1/mcl2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_Kinase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040442">
        <property type="entry name" value="Pyrv_Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03328">
        <property type="entry name" value="HpcH_HpaI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015582">
        <property type="entry name" value="Cit_lyase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="SSF51621"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HpcH_HpaI" evidence="5">
        <location>
            <begin position="12"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="73"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3 4">
        <location>
            <position position="139"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="166"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR015582-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR015582-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF03328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PJN13498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="321" mass="35117" checksum="17F223B159A8BF5E" modified="2018-04-25" version="1">MTAPINRLRPRRSCLAVPGSNPRFLEKAQGLPADQVFLDLEDACAPLAKPEARHTIVKFLNEGDWTGKTRVVRVNDWTTEWTYRDVVTVVEGAGQNLDCIMLPKVQDAQQIVALDLLLTQIEKTMGFETGKIGIEAQIENAQGLNNVNTIATASQRVETIIFGPADFMASINMKSLVVGEQPPGYDADAYHYILMKILMAARANNLQAIDGPYLQIRNQEGYKAVAKRAAALGFDGKWVLHPDQVAAANEIFSPSQEDYDHAELILDAYDFCTSEAGGKKGSAMLGDEMIDEASRKMALVISGKGRAAGMQRTSKFEAPEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K2Z5</accession>
    <name>A0A2M9K2Z5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Branched-chain amino acid ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CG723_02690</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CB01635</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000001">
        <property type="protein sequence ID" value="PJN13489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN13489">
        <property type="protein sequence ID" value="PJN13489"/>
        <property type="gene ID" value="CG723_02690"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015658">
        <property type="term" value="F:branched-chain amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06581">
        <property type="entry name" value="TM_PBP1_LivM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001851">
        <property type="entry name" value="ABC_transp_permease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043428">
        <property type="entry name" value="LivM-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30482">
        <property type="entry name" value="PTHR30482"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02653">
        <property type="entry name" value="BPD_transp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="27"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="50"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="75"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="110"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="138"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="198"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="247"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="284"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="339"/>
            <end position="359"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PJN13489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="372" mass="38661" checksum="E10A21636ED879C6" modified="2018-04-25" version="1">MSEAVTRTEQPARRSVRRPAFLARRRTYVSAAGAVLLLALPFYVDRFWLQAGLFAMAAAIGATGLNLLTGATGQLSMGHAFFLAVGAYGYCVFAGDGDGADGLTGLGLPTWLAAVLAVLVAGVAGGVFSPIAGRLRGAYLGIATLALIFIGQHMLFNARDLTGGFNGRDVPPLHLFGLTFDDSELVVAAVPFGSAEKLWYLGLVLLLAGGLFARGVLRGRPGRAMNAIRDHRVAAGVIGVPVARYRAAVFVLSSMYAGLAGVLLALVFQRTVPEYFGMTLSLDYLAMIVIGGLGSVSGAVIGAAFVSLLPQILTRYSDLLPLVSAPGTGGIAPGEAARYLYGAAVVAVVLFLPGGLVRITARHGRPTPQEDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K3B1</accession>
    <name>A0A2M9K3B1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">4-carboxymuconolactone decarboxylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CG723_03435</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000001">
        <property type="protein sequence ID" value="PJN13618.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN13618">
        <property type="protein sequence ID" value="PJN13618"/>
        <property type="gene ID" value="CG723_03435"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047570">
        <property type="term" value="F:3-oxoadipate enol-lactonase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051920">
        <property type="term" value="F:peroxiredoxin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042952">
        <property type="term" value="P:beta-ketoadipate pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029032">
        <property type="entry name" value="AhpD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003779">
        <property type="entry name" value="CMD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012788">
        <property type="entry name" value="Decarb_PcaC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026968">
        <property type="entry name" value="PcaD/CatD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02627">
        <property type="entry name" value="CMD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00111">
        <property type="entry name" value="ABHYDROLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69118">
        <property type="entry name" value="SSF69118"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02425">
        <property type="entry name" value="decarb_PcaC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02427">
        <property type="entry name" value="protocat_pcaD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="2">
        <location>
            <begin position="23"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="domain" description="AB hydrolase-1" evidence="2">
        <location>
            <begin position="187"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="domain" description="CMD" evidence="3">
        <location>
            <begin position="289"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02627"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PJN13618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="384" mass="40395" checksum="5C30DB115B78AE44" modified="2018-04-25" version="1">MSTASPDRGPLLHHRAEGPATAPPLLLGPSLGTSTALWDMVAPELSVTHRVVRWDLPGHGKSPAGLIGPGATVADLAGLVLDLADSLGIERFAYAGVSLGGAVGLHLAVHHPERVTSLAVICSSAHFGGSKPWEERAALVRREGLGPVAETADRRWFTPGFTVPALIEDHRTANSDAYAACCDALAAFDIREELASITAPTLLIAGREDPATPPAHLREIADAVPGSSLVEIAGASHLAPAQCPEPVITALRAQLGGGARRGMEVRRQVLGDAHVDRAQARQSPFTARFQDFISRYAWGEIWTDPTLARRERSMITMTALVAHGHYDELAMHVRAALRNGLTPDEIGAVLLQSAVYCGVPAANSAFAVAQRVLAEESGEDPAAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K3E9</accession>
    <name>A0A2M9K3E9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Carnitine dehydratase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_03580</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000001">
        <property type="protein sequence ID" value="PJN13639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN13639">
        <property type="protein sequence ID" value="PJN13639"/>
        <property type="gene ID" value="CG723_03580"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10540">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003673">
        <property type="entry name" value="CoA-Trfase_fam_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044855">
        <property type="entry name" value="CoA-Trfase_III_dom3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023606">
        <property type="entry name" value="CoA-Trfase_III_dom_1_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02515">
        <property type="entry name" value="CoA_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89796">
        <property type="entry name" value="SSF89796"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="332"/>
            <end position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN13639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="378" mass="39340" checksum="82C6FF9AA277C7C9" modified="2018-04-25" version="1">MAVAGMTDSGPLAGVRVVELAGIGPGPFAAMLLADLGADVVRVDRPGGAGLAINPEYDITNRNKRSVIIDLKADDGPARVLDLVAKADVLIEGYRPGVAERLGVGPDACHARNPRLVYGRMTGWGQDGPLAQRAGHDIAYIALTGTLGMIGKPDEPPTVPANLVGDYAGGSLYLVVGILAALHHARDTGAGQVVDAAIVDGASHLAAMIHGMLAAGGWQDRRGSNLLDGGCPFYGTYETSDGQYMAVGALEQQFYDEFSALLGIGDTAPARKDLARWGELRDAVAARFKTRTREEWTAVFEGSDACVAPVLSLREAPGHPHLAARGTFTDHGGITQPAPAPRFSATPTAVRSGPAQPGADTAGVARDWDVPSLTKEEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K3Q0</accession>
    <name>A0A2M9K3Q0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">HAMP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CG723_01150</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000001">
        <property type="protein sequence ID" value="PJN13739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN13739">
        <property type="protein sequence ID" value="PJN13739"/>
        <property type="gene ID" value="CG723_01150"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00672">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00304">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="304"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="658"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="3">
        <location>
            <begin position="326"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="3">
        <location>
            <begin position="677"/>
            <end position="729"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="725"/>
            <end position="744"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PJN13739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="744" mass="78857" checksum="19A1E657372DE99C" modified="2018-04-25" version="1">MSLLGGIRPPIAVLSVLLLALAGITALTLGRVGHDRVPEAVRTSQQHFAEDGAIGLRASVDEGVTDLTRTAALFSAGDPVSADAVLDKIGNVYQKWMGTAVVEIKSGKLLAARGENVPLTAIDRAKLSDDNGLAPRMVRLQNGETRLLTFALLNWKGQPQQLLVASNSLKFPGISLGEFRSIAVIDQAGTILSSDGIPEPEQVLTDLQRAEVKESNRQLKAFAKSAAGKAEQHPIKSKEPGSGGFLGVSGSLSGDRYMGERSVAGYAALASPQPGEPTVATGLGLTVVAMVKVAEDPAVTASPMFGLAAAAALLLIGGLTVTLLLGTVQRPLIRLFLESRRITRGDLARPVAVPRRGEAARIGAALERLRRQLLGELPQPAAPARRRFGARSLLAVAGVLLLVWSGPLLLMLNRAGDTVVVPQQMVNDQRERTDTLSDRVRRALNEGHADLMSVASLIGDRTKPSQMTEVLEATMNEHERYESLYVLDAQGNVLARSGHGPHNEKGEGPSAQPIRVLDDQGKKPVIVGTAELPGRQGAAVVGEFRIDFLNSLLKRPGLGDVRVVDAERRVIGGNTGYLAFHKLPGNRLDELADGTNQKVGMSPRPSGVLFRDGGDIQIAAAAPFVGGGAAKSLGWTVVSWQPASSLAIPEYSLQNRTVLAGLLGITAAAACLGWLHIVVVRPLRDLARQAESLADGDRKTVLFPRHHDEVGAVARSLELIRQQVQSQQRKRDGGARTPAGAGRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JF95</accession>
    <name>A0A2M9JF95_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">FAD-linked oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CG723_45030</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CB01635</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the oxygen-dependent FAD-linked oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000049">
        <property type="protein sequence ID" value="PJN05427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN05427">
        <property type="protein sequence ID" value="PJN05427"/>
        <property type="gene ID" value="CG723_45030"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.43.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012951">
        <property type="entry name" value="BBE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016167">
        <property type="entry name" value="FAD-bd_PCMH_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006093">
        <property type="entry name" value="Oxy_OxRdtase_FAD_BS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08031">
        <property type="entry name" value="BBE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="SSF56176"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00862">
        <property type="entry name" value="OX2_COVAL_FAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="3">
        <location>
            <begin position="48"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="463"/>
            <end position="518"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PJN05427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="518" mass="52974" checksum="CB982AB0BEBC2496" modified="2018-04-25" version="1">MQSHAHADARYAVSTALLAELRSRIPAGRVLANGPEYAKAVALFNAAVDVCPAVVVRCATTADVQAAIRVSRNHGVPISVRGGGHDFWGRAFRPGGLVLDLTGMRGVQVDIGRRFATVGGGALSSDVVSAAEPAGLTAVTGTAGAVGMVGLTLGGGYGPLIGQFGLAADNLLGAEVVLADGSRVHTDADHHPDLFWALRGGGGNFGVVTSARIRLHPVPTVVSGTILYPIVQSAGILADLGGILQDCPDELTVDVGFLPGPDGKPTVYVAPTWSGDIEVGNAENGPVRALARLGTPVLAEIGPVARSAALAATDTMFPPGRMGAIRTRTVQSISGSIAPVLDRAAQEFTSPFSAIVWHQFHGAAARLPLGSTAFGRREPHLMVELISLWEGESKGNAGAGDGRSPHLRWLEALHAALEPFSLPGGYVNFLGPETPDQVAESYGPNTERLLAVKSAVDPDSVFAATPLPSGSADAGSRPVSGVEPEHRGVPAVPPENGIGSSDIGHVGLGLSPRGPSDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JFK2</accession>
    <name>A0A2M9JFK2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Nitroreductase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_43665</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000044">
        <property type="protein sequence ID" value="PJN05602.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN05602">
        <property type="protein sequence ID" value="PJN05602"/>
        <property type="gene ID" value="CG723_43665"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.109.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029479">
        <property type="entry name" value="Nitroreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000415">
        <property type="entry name" value="Nitroreductase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00881">
        <property type="entry name" value="Nitroreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55469">
        <property type="entry name" value="SSF55469"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nitroreductase" evidence="1">
        <location>
            <begin position="8"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN05602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="222" mass="24691" checksum="FC05457A7B9D1238" modified="2018-04-25" version="1">MDVYEAVTSRRAVRGFTDRQVPREVLKRVLSAAAWSPSGSNIQPWHAYVLTGGPLAELKKRAGERLAAGDPWDEPEYEQYPLSLKSPYHERRSAFGEQRYGALGIAREDLEARQRAASANWDCFGAPAALFCYIDRDMGPAQWADVGMYLQTVMLLLRAEGLNSCPQMAWAKFHRTVAEVLSPPDELMLFCGMSIGFEDVTVSDARTGRAPLDETVTFVDGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-09-29" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JFW4</accession>
    <name>A0A2M9JFW4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CG723_43165</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000042">
        <property type="protein sequence ID" value="PJN05732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN05732">
        <property type="protein sequence ID" value="PJN05732"/>
        <property type="gene ID" value="CG723_43165"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009078">
        <property type="entry name" value="Ferritin-like_SF"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47240">
        <property type="entry name" value="SSF47240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PJN05732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="262" mass="29502" checksum="8E220321D46EBFDA" modified="2018-04-25" version="1">MLSAKSLFQEILDDDESFRLFCSIAASGESQGGWENGRIAALVPAGERDLAPKVARHGADEDKHGRIFNALMKKRGLKPVDVPPETDYTMLLEKHGIGLAHEQLKADEPLTVRDIVTYLAHSRVTEQRASEQMDLLRKYFADDPDIGRAVKMISADEDNHLAYCHEELLRFAYAGHGRDIQRILRECALEEIRVYRDVSLAVMDHMGHILRWPKPKVALLAAGIHAMYAYERLVGWRRMVSLEMPERRNALGGPATSAVEFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JG32</accession>
    <name>A0A2M9JG32_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cupin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_43085</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000042">
        <property type="protein sequence ID" value="PJN05717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN05717">
        <property type="protein sequence ID" value="PJN05717"/>
        <property type="gene ID" value="CG723_43085"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013096">
        <property type="entry name" value="Cupin_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07883">
        <property type="entry name" value="Cupin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cupin_2" evidence="1">
        <location>
            <begin position="78"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN05717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="173" mass="18982" checksum="34180B410F7263C1" modified="2018-04-25" version="1">MPLTTTDYDNGSDLGKYTDSLIATKESRVADFNTLSFQEKAGPQYRRGQIRYVGSGATGNHENDSRILPSGGFTFSNMLLPPGAEGPEHTHHDVEEAFFVLEGQVRVGIHRGADEVEYRTLGYRDMIVVPAGVARSLKNEGDTDALFCVVIGTQKPQVPTYPEHSPMHGVTRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JG52</accession>
    <name>A0A2M9JG52_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="11 12">Protein translocase subunit SecA</fullName>
            <ecNumber evidence="11">7.4.2.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">secA</name>
        <name evidence="17" type="ORF">CG723_42260</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">CB01635</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Monomer and homodimer. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF. Other proteins may also be involved.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Cell membrane</location>
            <topology evidence="11">Peripheral membrane protein</topology>
            <orientation evidence="11">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="11">Cytoplasm</location>
        </subcellularLocation>
        <text evidence="11">Distribution is 50-50.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 11 12">Belongs to the SecA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.4.2.8" evidence="11"/>
    <dbReference type="EMBL" id="NNBL01000039">
        <property type="protein sequence ID" value="PJN05864.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN05864">
        <property type="protein sequence ID" value="PJN05864"/>
        <property type="gene ID" value="CG723_42260"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0065002">
        <property type="term" value="P:intracellular protein transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017038">
        <property type="term" value="P:protein import"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006605">
        <property type="term" value="P:protein targeting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd18803">
        <property type="entry name" value="SF2_C_secA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01382">
        <property type="entry name" value="SecA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000185">
        <property type="entry name" value="SecA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020937">
        <property type="entry name" value="SecA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011115">
        <property type="entry name" value="SecA_DEAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014018">
        <property type="entry name" value="SecA_motor_DEAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011130">
        <property type="entry name" value="SecA_preprotein_X-link_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044722">
        <property type="entry name" value="SecA_SF2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011116">
        <property type="entry name" value="SecA_Wing/Scaffold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036266">
        <property type="entry name" value="SecA_Wing/Scaffold_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036670">
        <property type="entry name" value="SecA_X-link_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30612">
        <property type="entry name" value="PTHR30612"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07517">
        <property type="entry name" value="SecA_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01043">
        <property type="entry name" value="SecA_PP_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07516">
        <property type="entry name" value="SecA_SW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00906">
        <property type="entry name" value="SECA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00957">
        <property type="entry name" value="SecA_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00958">
        <property type="entry name" value="SecA_PP_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81767">
        <property type="entry name" value="SSF81767"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81886">
        <property type="entry name" value="SSF81886"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00963">
        <property type="entry name" value="secA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01312">
        <property type="entry name" value="SECA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51196">
        <property type="entry name" value="SECA_MOTOR_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 11" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 11 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 11 12" id="KW-0653">Protein transport</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 11" id="KW-1278">Translocase</keyword>
    <keyword evidence="9 11 12" id="KW-0811">Translocation</keyword>
    <keyword evidence="2 11 12" id="KW-0813">Transport</keyword>
    <feature type="domain" description="SECA_MOTOR_DEAD" evidence="16">
        <location>
            <begin position="1"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="14">
        <location>
            <begin position="87"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="15">
        <location>
            <begin position="426"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="875"/>
            <end position="934"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="904"/>
            <end position="923"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="85"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="103"/>
            <end position="107"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="504"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007650"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="PJN05864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="934" mass="105020" checksum="8803551271B51620" modified="2018-04-25" version="1">MSVLSKIMRAGEGKILRKLHRIADQVNSLEEDFVSLSDAELRALTDEYKERFADGESLDDLLPEAFATVREAARRVLGQRPYDVQLMGGAALHLGYVAEMKTGEGKTLVGTLPTYLNALSGKGVHLITVNDYLAERDSEMMGRVHKFLGLSVGCILANMTPAQRREQYSCDITYGTNNEFGFDYLRDNMAWSQDELVQRGHNFAVVDEVDSILVDEARTPLIISGPADQATKWYGDFAKLVTRLKKGEAGNPLKGIEETGDYEVDEKKRTVAIHEPGVAKVEDWLGIDNLYESVNTPLVGYLNNAIKAKELFKKDKDYVVIDGEVMIVDEHTGRILAGRRYNEGMHQAIEAKEGVDIKDENQTLATITLQNFFRLYDKLSGMTGTAMTEAAEFHQIYKLGVVPIPTNKPMVRKDQADLIYRTEVAKFDAVVDDIAEKHEQGQPILVGTTSVEKSEYLSQQLSKRGVQHEVLNAKQHDREATIVAQAGRKGAVTVATNMAGRGTDIKLGGNPDDLAEAELRQRGLDPVEHVEEWAAALPGALERAEQAVKAEFEEVKDLGGLYVLGTERHESRRIDNQLRGRSGRQGDPGESRFYLSLGDDLMRLFKAQMVERVMSMANVPDDVPIENKMVTRAIASAQSQVEQQNFETRKNVLKYDEVLNRQREVIYGERRRVLEGEDLHEQIQHFMDDTIDEYIGAETAEGFAEEWDLDRLWGAFKQLYPVKVTVDELEEAAGDRAGLTAEFIGESVKDDIHAQYAAREEQLGSEIMRELERRVVLSVLDRKWREHLYEMDYLQEGIGLRAMAQKDPLVEYQREGFDMFTAMMEGIKEESVGYLFNLEVQVEQQVEEVEVQDVAPSLDKQDAVPAGVGRPEIRAKGLDAPQRPDRLHFQAPNAEGGVDEMDYVTEDGPTRSEADGLTRAERRKQQKGGRRRKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JGH3</accession>
    <name>A0A2M9JGH3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DUF305 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CG723_41770</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000037">
        <property type="protein sequence ID" value="PJN05978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN05978">
        <property type="protein sequence ID" value="PJN05978"/>
        <property type="gene ID" value="CG723_41770"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005183">
        <property type="entry name" value="DUF305"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012347">
        <property type="entry name" value="Ferritin-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03713">
        <property type="entry name" value="DUF305"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014650725" evidence="2">
        <location>
            <begin position="40"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="domain" description="DUF305" evidence="3">
        <location>
            <begin position="82"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="36"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PJN05978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="225" mass="23807" checksum="CA5B80C0540DA6A5" modified="2018-04-25" version="1">MHRSTDGNVLVMKVVLPLTVAVAALVLGGCDTAPDDGGADTNSRARPGPSVIAPGKPGEGAETLSAEDAQKRRPDDSPNSADFSYAQMMIAHHTQALQMTELAPKRAESGQVKRLAERIAAAQGPEVGAMEGWLNSHGRERESGGHHEHGAMPGMATEAQLKTLRAAHGAAFDELFLKLMITHHTGAVTMATDVLSEGNNVQVEEMANDVIAQQTAEIGRMRKMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-09-29" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JGK6</accession>
    <name>A0A2M9JGK6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CG723_41130</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CB01635</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000036">
        <property type="protein sequence ID" value="PJN06016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN06016">
        <property type="protein sequence ID" value="PJN06016"/>
        <property type="gene ID" value="CG723_41130"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010290">
        <property type="entry name" value="TM_effector"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05977">
        <property type="entry name" value="MFS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="35"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="61"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="88"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="118"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="235"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="264"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="299"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="323"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="366"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="392"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="232"/>
            <end position="439"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PJN06016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="439" mass="46822" checksum="5BAAAE248F401CB7" modified="2018-04-25" version="1">MTAPEPSPDRPANRGGLWRHADFRRLWVGETVSQFGTMVSQLALPLVAILVLHASTWQVGVLAACETAAFVAVGLPAGAWVERMRFRWVLIVNNLVRAALLAWVPVAQLLGVLTIEQLYVVTLATGVSTVFFDVAYQSYLPQLIDRELLVEGNAKLQASESVSQIAGPSLGGALIQALTAPYALLVDAVSFLWSAAWVTRIEVRPPRPERSPDPNLLREIRDGLRFVLANRILRAIAMCTSSANLFGSVISAVFYVLLARQLRLSPGVIGLLTSTAAVGGLIGALVAGRFAAKVGQGPAIWIASAVAGPCALVTPFVQRDWTVGLLAAAQTAMWMGIVVYNINQVSFRQALCPPGLLGRMNATMRFLVWGTMPFGALLGGLLGSTIGVRGTLLAGAVGQSLTFLPVFLSPLRRMRELPSYAELAAEGDTAAGPLVPREP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JGZ3</accession>
    <name>A0A2M9JGZ3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CG723_40980</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000035">
        <property type="protein sequence ID" value="PJN06149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN06149">
        <property type="protein sequence ID" value="PJN06149"/>
        <property type="gene ID" value="CG723_40980"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PJN06149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="252" mass="28116" checksum="B2AA01072F6FF650" modified="2018-04-25" version="1">MEQDLAQPAGGQSLSVQDARLKADQRLVDILRSDGFTGSRYDKASAGWWSYGWRIMVKWSRTGEIFARSRKAGRPVPPSVITTSWSKDDRYQVATDTMIGGMELFRERGLVQGGWNPEGGASLTTYVVGAAVRSFRPVYLAWFRDQQTGHTELNAQSGTHDDESQRDIPDQRAVDPYYAAATADELARLLPHITDPQVREGLGWRALGYTEAEAAERVGLTQKALERRLSRTRSRVLNAYLREPELGEGGAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JHF5</accession>
    <name>A0A2M9JHF5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Pristinamycin IIA synthase subunit A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CG723_39810</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CB01635</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the NtaA/SnaA/DszA monooxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000032">
        <property type="protein sequence ID" value="PJN06292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN06292">
        <property type="protein sequence ID" value="PJN06292"/>
        <property type="gene ID" value="CG723_39810"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01095">
        <property type="entry name" value="Nitrilotriacetate_monoxgenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011251">
        <property type="entry name" value="Luciferase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036661">
        <property type="entry name" value="Luciferase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016215">
        <property type="entry name" value="NTA_MOA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00296">
        <property type="entry name" value="Bac_luciferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000337">
        <property type="entry name" value="NTA_MOA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51679">
        <property type="entry name" value="SSF51679"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03860">
        <property type="entry name" value="FMN_nitrolo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="2" id="KW-0288">FMN</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bac_luciferase" evidence="4">
        <location>
            <begin position="19"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="408"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="59"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="101"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="151"/>
            <end position="155"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="204"/>
            <end position="207"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00033748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000337-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PJN06292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="430" mass="47309" checksum="94674A4A3F4D626D" modified="2018-04-25" version="1">MTTPRRRITLAGIIDGPGGHVAAWRHPSTQADAQLDFEFHKRNARTLERGLFDAVFIADIVAVWGTRLDSLCRTSRTEHFEPLTLLAAYAAATEHIGLCATATTTYNEPAHIARRFASLDHLSGGRAGWNVVTSAAPWESANFGFPEHLEHGLRYQRAEEFIDVVKQLWDSGERSIGHHGEHFTVEGPLDIARPPQGRPVIIQAGSSPVGREFAARHAEVIFTRHNTLPDAQSFYTDLKKRVSAQGRDPEKVLVWPTLAPIVAATEAEAQARLQELQDLTHDHVALRTLQDFLGDVDLSAYPIDGPVPDIPYTNQSQSTTERLVGLARSENLSIRQLALRLMGDIVVGTPEQLADHMESWFTGRGADGFNIDFPYLPGSADDFVDHVIPELQRRGLYRTSYEGSTLRENLGLDAPAPGQPADRTTAGATA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JHJ5</accession>
    <name>A0A2M9JHJ5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_39490</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000031">
        <property type="protein sequence ID" value="PJN06350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN06350">
        <property type="protein sequence ID" value="PJN06350"/>
        <property type="gene ID" value="CG723_39490"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="52"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN06350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="77" mass="8146" checksum="17982327CD957361" modified="2018-04-25" version="1">MSEGAPVTVHPPLPDGGRRVTIRGKDVGTAYNLLDVLEFLRAAGLPEADTTVDDPELIDWHGAGPENWGPDGPEQAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-05-25" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JHL8</accession>
    <name>A0A2M9JHL8_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Endolytic murein transglycosylase</fullName>
            <ecNumber evidence="7">4.2.2.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Peptidoglycan polymerization terminase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">mltG</name>
        <name evidence="9" type="ORF">CG723_39630</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CB01635</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cell membrane</location>
            <topology evidence="7">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the transglycosylase MltG family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.2.-" evidence="7"/>
    <dbReference type="EMBL" id="NNBL01000031">
        <property type="protein sequence ID" value="PJN06371.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN06371">
        <property type="protein sequence ID" value="PJN06371"/>
        <property type="gene ID" value="CG723_39630"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008932">
        <property type="term" value="F:lytic endotransglycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd08010">
        <property type="entry name" value="MltG_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02065">
        <property type="entry name" value="MltG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003770">
        <property type="entry name" value="MLTG-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30518">
        <property type="entry name" value="PTHR30518"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02618">
        <property type="entry name" value="YceG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00247">
        <property type="entry name" value="TIGR00247"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 7" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="5 7 9" id="KW-0456">Lyase</keyword>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014676889" description="Endolytic murein transglycosylase" evidence="8">
        <location>
            <begin position="32"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="site" description="Important for catalytic activity" evidence="7">
        <location>
            <position position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PJN06371.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="282" mass="30151" checksum="D378D0016A094FF3" modified="2018-04-25" version="1">MLNETPQRSTMRLTRRGRASLIAGGALVAAAAAVVVPLLLPHHGGGDKRPQALTVPEGWRARQVYEALDKALGVPAGTSKRAVPKAGLKLPGDAGGNPEGYLFPATYPLNDKSTPAGLLSYMVNTANRKLNGSQVTAGADRDAVNPYQTLTIASIVEAEAATKEDMGKVARVIYNRLDRGMPLQMDSTINYGLNRSTLDTTTKDTRAENPYNTYVRMGLPPTPIANPGAEAMKAAISPPQGDWVYFVTVKPGDTRFTADFNEQQKNVAEFNKLRTSGKPSSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JHY8</accession>
    <name>A0A2M9JHY8_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">2-isopropylmalate synthase</fullName>
            <ecNumber evidence="3">2.3.3.13</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Alpha-IPM synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="3">Alpha-isopropylmalate synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3 6" type="primary">leuA</name>
        <name evidence="6" type="ORF">CG723_38870</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CB01635</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>3-methyl-2-oxobutanoate + acetyl-CoA + H2O = (2S)-2-isopropylmalate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:21524"/>
            <dbReference type="ChEBI" id="CHEBI:1178"/>
            <dbReference type="ChEBI" id="CHEBI:11851"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="EC" id="2.3.3.13"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid biosynthesis; L-leucine biosynthesis; L-leucine from 3-methyl-2-oxobutanoate: step 1/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.3.13" evidence="3"/>
    <dbReference type="EMBL" id="NNBL01000029">
        <property type="protein sequence ID" value="PJN06506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN06506">
        <property type="protein sequence ID" value="PJN06506"/>
        <property type="gene ID" value="CG723_38870"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00048">
        <property type="reaction ID" value="UER00070"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003852">
        <property type="term" value="F:2-isopropylmalate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009098">
        <property type="term" value="P:leucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07942">
        <property type="entry name" value="DRE_TIM_LeuA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00572">
        <property type="entry name" value="LeuA_type2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013709">
        <property type="entry name" value="2-isopropylmalate_synth_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002034">
        <property type="entry name" value="AIPM/Hcit_synth_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005668">
        <property type="entry name" value="IPM_Synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036230">
        <property type="entry name" value="LeuA_allosteric_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039371">
        <property type="entry name" value="LeuA_N_DRE-TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000891">
        <property type="entry name" value="PYR_CT"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00682">
        <property type="entry name" value="HMGL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08502">
        <property type="entry name" value="LeuA_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00917">
        <property type="entry name" value="LeuA_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110921">
        <property type="entry name" value="SSF110921"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00970">
        <property type="entry name" value="leuA_yeast"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00815">
        <property type="entry name" value="AIPM_HOMOCIT_SYNTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00816">
        <property type="entry name" value="AIPM_HOMOCIT_SYNTH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50991">
        <property type="entry name" value="PYR_CT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="2 3" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="3" id="KW-0432">Leucine biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pyruvate carboxyltransferase" evidence="5">
        <location>
            <begin position="45"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PJN06506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="574" mass="62696" checksum="079B913D68B5CB25" modified="2018-04-25" version="1">MTTAYDWNPQQPGPMPYHRYRPHHDRVDVPVRERSWPGARIERAPLWVPVDLRDGNQALAEPMDTGRKRRFFDLLVRTGFKEIEVGYPSASRTDFDFVRHLVTSGAVPDDVTPVVFTPARRDLIERTFASIEGLPRAVVHLYIPTSRVWRDVVLGRDRPQVWETVRDAAAHMARLADARPGAHIRFQFAPETFNVTEPDFVLEICDGLTELWDASPDRPVTHNLPATVEIATPNVYADQIEYTHKNLSRRDSVILSVHPHNDRGTGVACAELAVLAGAQRVEGCLFGNGERTGNVDLVTLAMNLYAQGVDPMVDFSDIDAVREVVEHCNRLPVHPRHPYGGDLVYTAFSGTHQDAISKGLAHHAASAAAAGVPAQEARWDVPYLPIDPADVGRSYEAVIRVNSQSGKGGMAYLLATHHGVDLPARMRPEYARVVQEATDDSGHEATPKDLYELFRSTYLEPGRGAGHLSLTAWSTDGDGQAHRFVCTLQVGDRTGDFEGRGGGTLSAFVDALAAAGVGVDIVDFTEDAHGAEATAYAQCRVDGVTAWGAGRDPSPLVASVQAVLAAVNRAVAVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JI26</accession>
    <name>A0A2M9JI26_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_38195</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000028">
        <property type="protein sequence ID" value="PJN06539.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN06539">
        <property type="protein sequence ID" value="PJN06539"/>
        <property type="gene ID" value="CG723_38195"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1220.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013321">
        <property type="entry name" value="Arc_rbn_hlx_hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010985">
        <property type="entry name" value="Ribbon_hlx_hlx"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47598">
        <property type="entry name" value="SSF47598"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="66"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN06539.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="90" mass="9894" checksum="FE5C121D025908DB" modified="2018-04-25" version="1">MSPSEEEREGPPEGPARRSRPQRKQVLLRLDPLVYDALARWAGDDLRSANAQIEFLLRRALAEAGRLPGSAGPLPRRGRPPKGSQGDEAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JI81</accession>
    <name>A0A2M9JI81_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CG723_38385</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000028">
        <property type="protein sequence ID" value="PJN06570.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN06570">
        <property type="protein sequence ID" value="PJN06570"/>
        <property type="gene ID" value="CG723_38385"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PJN06570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="63" mass="6833" checksum="F0E8A38FE3BBE63A" modified="2018-04-25" version="1">MPTITWEDPFCGEGANCFRLGTDPDGNAYITVAGGEETYLTDSREALRAMILDIKAGKADHLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JID8</accession>
    <name>A0A2M9JID8_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Homogentisate 1,2-dioxygenase</fullName>
            <shortName evidence="6">HGDO</shortName>
            <ecNumber evidence="6">1.13.11.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Homogentisate oxygenase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Homogentisic acid oxidase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Homogentisicase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">hmgA</name>
        <name evidence="7" type="ORF">CG723_37875</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CB01635</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Involved in the catabolism of homogentisate (2,5-dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>homogentisate + O2 = 4-maleylacetoacetate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15449"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16169"/>
            <dbReference type="ChEBI" id="CHEBI:17105"/>
            <dbReference type="EC" id="1.13.11.5"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="6">Amino-acid degradation; L-phenylalanine degradation; acetoacetate and fumarate from L-phenylalanine: step 4/6.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Hexamer; dimer of trimers.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the homogentisate dioxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.13.11.5" evidence="6"/>
    <dbReference type="EMBL" id="NNBL01000027">
        <property type="protein sequence ID" value="PJN06656.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN06656">
        <property type="protein sequence ID" value="PJN06656"/>
        <property type="gene ID" value="CG723_37875"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00139">
        <property type="reaction ID" value="UER00339"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004411">
        <property type="term" value="F:homogentisate 1,2-dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006559">
        <property type="term" value="P:L-phenylalanine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006572">
        <property type="term" value="P:tyrosine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00334">
        <property type="entry name" value="Homogentis_dioxygen"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005708">
        <property type="entry name" value="Homogentis_dOase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022950">
        <property type="entry name" value="Homogentis_dOase_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11056">
        <property type="entry name" value="PTHR11056"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04209">
        <property type="entry name" value="HgmA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01015">
        <property type="entry name" value="hmgA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="3 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5 6" id="KW-0585">Phenylalanine catabolism</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0828">Tyrosine catabolism</keyword>
    <feature type="active site" description="Proton acceptor" evidence="6">
        <location>
            <position position="294"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="373"/>
        </location>
        <ligand>
            <name>homogentisate</name>
            <dbReference type="ChEBI" id="CHEBI:16169"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PJN06656.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="438" mass="48145" checksum="0D4FCEED590FCDAB" modified="2018-04-25" version="1">MRDARKTAEGLAYLSGFGNEHSSEAVPGALPHGRNSPQRAPLGLYAEQLSGTAFTEPRAYNRRSWLYRIRPSAAHPAFVRADNGALRTAPFTESVPDPNRLRWNPLPEPAPGTDFLAGLWTLGGNGDATQRTGMAVHLYHANSSMTDRVFSDADGELLIVPERGGLLLRTEFGLLHAEPGHVALIPRGVRFRVELLDAEARGYVCENYGSPFRLPDLGPIGANGLANARDFMVPVAAYEDTEGPVEVVNKFCGNLWRATYGHSPLDVVAWHGNHVPYVYDLRRFNVIGSLSYDHPDPSIFTVLTSPSDTPGLAGVDFVVFAPRWLVGEDTFRPPYFHRNVMSEYMGLIEGAYDAKAEGFVPGGGSLHNMMSAHGPDRETFDKASAAQLRPQKIDDGLAFMFETRWPVTATAQAAQADHLQRGYDDVWSGLERHFRTSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JIJ2</accession>
    <name>A0A2M9JIJ2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Amino acid permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CG723_38075</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CB01635</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000027">
        <property type="protein sequence ID" value="PJN06684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN06684">
        <property type="protein sequence ID" value="PJN06684"/>
        <property type="gene ID" value="CG723_38075"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004841">
        <property type="entry name" value="AA-permease/SLC12A_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00324">
        <property type="entry name" value="AA_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="41"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="72"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="110"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="153"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="179"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="220"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="257"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="312"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="358"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="398"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="432"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="471"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="domain" description="AA_permease" evidence="6">
        <location>
            <begin position="48"/>
            <end position="426"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PJN06684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="520" mass="53277" checksum="0C7415B58CBF7FBE" modified="2018-04-25" version="1">MTTGSSSTSDTAPPPASDAGINTFKGQESALRAGRLGTAGLLLSVLAATGPLMVVAGVMPTTFAVMGVVGQPLLFLILGVVLALFSVGYAEMSRHVHNAGAFYAYISRGLGPTAGAGAALVALVAYSVLQVGIYGMFGFEVSNLLATYLDLSIAWWIPALVAVLAVGALALLKIDVNARVLGVLLLVEVALVVIFDIAAIGDPAKEGLSLHAFNPDTLTGAGVGTALCFCIAAFTGFEQAPVYAEETSRPHILVPRVMFMAVGFVAVFFAISSWALTVAAGPSAIIPTAQKQSAGLMFFLTESRLGGTFTDIVHVLFVTGMFAALLSFHNVVSRYAFAMGREGLLPATFGRTNSSSGAPGTGSLLQTALSLIIVVAFAVTDDGKAGDPTAPVLKLFTWGGNVGALGIILLMATASLAVIVFFVRRGAAGAQIWRLIASGIAGIALLVIAFYTVKDFDVLVGSGPGSSLNWVLPGIIALAAVIGFVHGVVLRGRNPEAHAGIGLGNEAFQLEKAAGVPAQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JJ18</accession>
    <name>A0A2M9JJ18_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_36950</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000025">
        <property type="protein sequence ID" value="PJN06869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN06869">
        <property type="protein sequence ID" value="PJN06869"/>
        <property type="gene ID" value="CG723_36950"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13581">
        <property type="entry name" value="HATPase_c_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HATPase_c" evidence="2">
        <location>
            <begin position="58"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="119"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN06869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="173" mass="18107" checksum="2A40CCB61AD6A621" modified="2018-04-25" version="1">MGTTRPYSPGDRGPEPEAAGDTGGTPGLPPADVGRAARHQSRRLNLVGAAGIVPLARDFTREALHAWGWMPAGTADRRAAAEDVLLVVSELVTNACLHAEGPDELRISCDSKVLRIEVSDRGAGQPAPRTPHRAGRPGGHGMFIVQRLCMDWGVVRAAGVPGKTVWAEVGAPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JJ23</accession>
    <name>A0A2M9JJ23_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Exopolyphosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_36785</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000025">
        <property type="protein sequence ID" value="PJN06842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN06842">
        <property type="protein sequence ID" value="PJN06842"/>
        <property type="gene ID" value="CG723_36785"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003695">
        <property type="entry name" value="Ppx_GppA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02541">
        <property type="entry name" value="Ppx-GppA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ppx-GppA" evidence="1">
        <location>
            <begin position="25"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN06842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="314" mass="33677" checksum="D0C47A3CAD4ECEC0" modified="2018-04-25" version="1">MTRVAAVDCGTNSIRLLVADADPVTGELVDLDRRMTIVRLGQGVDRTGRLAPEALERTFAACREYAEAIKAHGAEKIRFVATSASRDAENRDDFVRGVMDILGVEPEVITGDQEAEFSFTGATKELTGRADLDKPYLVVDIGGGSTEFVVGEDTVVAARSVDIGCVRMTERHLVGEDGQVTDPPTPAQIEAIREDVVAALDLVTQTVPLTAARTLVGLAGSVTTVAALALGLTEYDSVAIHHSRISYERVAELTDWLLTSTHDQRSLNPVIHPGRVDVIASGALVLRLIMEWIGAKEVVVSEHDILDGIAWSIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JJ76</accession>
    <name>A0A2M9JJ76_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">6-phosphogluconate dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CG723_36040</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000024">
        <property type="protein sequence ID" value="PJN06919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN06919">
        <property type="protein sequence ID" value="PJN06919"/>
        <property type="gene ID" value="CG723_36040"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016054">
        <property type="term" value="P:organic acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006115">
        <property type="entry name" value="6PGDH_NADP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015815">
        <property type="entry name" value="HIBADH-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029154">
        <property type="entry name" value="NADP-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14833">
        <property type="entry name" value="NAD_binding_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03446">
        <property type="entry name" value="NAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000103">
        <property type="entry name" value="HIBADH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="SSF48179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD_binding_2" evidence="2">
        <location>
            <begin position="10"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="domain" description="NAD_binding_11" evidence="3">
        <location>
            <begin position="175"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR000103-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF14833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PJN06919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="315" mass="32847" checksum="E050EE58EC0F8913" modified="2018-04-25" version="1">MTIAAQNRPRIGWIGVGRMGFQLAALLLDAGHDVAVYNRARAKAEPLAERGATIVDRPVDLADRDVVFTMVTASAALEAVTTGPDGVLTSPDAAPGVLIDCSTVSTQVSALIRDEAAKRGTDFLAATVSGNPKVITAGKLTVAVSGSPEVFGQVEPFLALLGRGVTYVGEGEVARLVKIAHNVFLGVVTQSLAEITILAEKGGVSRAAFLQFLNDSVMGSVFTRYKSPALVNLDFTPTFTMPLLRKDFDLGLSAARELEVPMPLAAAAAQLVAAAIGAGHLEEDFASLILEQARNSGITPKAENVPVDDGLSPQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JJM8</accession>
    <name>A0A2M9JJM8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Cellulase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CG723_36445</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CB01635</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 5 (cellulase A) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000024">
        <property type="protein sequence ID" value="PJN06977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN06977">
        <property type="protein sequence ID" value="PJN06977"/>
        <property type="gene ID" value="CG723_36445"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071704">
        <property type="term" value="P:organic substance metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001547">
        <property type="entry name" value="Glyco_hydro_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00150">
        <property type="entry name" value="Cellulase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014618165" evidence="3">
        <location>
            <begin position="31"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="domain" description="Cellulase" evidence="4">
        <location>
            <begin position="78"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU361153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PJN06977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="343" mass="37995" checksum="4A63D1D46D865619" modified="2018-04-25" version="1">MARTRRISSAVAVAAAALGVAALSAGPATAAPRADTTQFKGVNWADPRDNFADDELQLSGLLTTDSYRETYSKAKRIISAFRANLGANTVRLPINPYTVKGSYWDSYQGVIDAASDQGFKVIVSYWEGTGERKDGLIDDTTTYWPMWTRVVDTYKNDSRVYFEPMNEPHGYTETEWADLAAKWLDTYSSVPRDRVFVSGAGYNDHVTSVCADPRLAGTYLSLHHYGFWKSYATYDQWVADLKERIGDCAGRTVADEFGSPMTTGLDYNVPTPDGNFVNYLQAVTDTFRELKMGSVYWPGLRSDDTYSLQTLTGTEDRPWLATTNQSGADRLAWAWGRGEAVGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JJU8</accession>
    <name>A0A2M9JJU8_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Peptide deformylase</fullName>
            <shortName evidence="2">PDF</shortName>
            <ecNumber evidence="2">3.5.1.88</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Polypeptide deformylase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2 3" type="primary">def</name>
        <name evidence="3" type="ORF">CG723_34715</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>H2O + N-terminal N-formyl-L-methionyl-[peptide] = formate + N-terminal L-methionyl-[peptide]</text>
            <dbReference type="Rhea" id="RHEA:24420"/>
            <dbReference type="Rhea" id="RHEA-COMP:10639"/>
            <dbReference type="Rhea" id="RHEA-COMP:10640"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:49298"/>
            <dbReference type="ChEBI" id="CHEBI:64731"/>
            <dbReference type="EC" id="3.5.1.88"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <text evidence="2">Binds 1 Fe(2+) ion.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the polypeptide deformylase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.88" evidence="2"/>
    <dbReference type="EMBL" id="NNBL01000022">
        <property type="protein sequence ID" value="PJN07151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN07151">
        <property type="protein sequence ID" value="PJN07151"/>
        <property type="gene ID" value="CG723_34715"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042586">
        <property type="term" value="F:peptide deformylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00487">
        <property type="entry name" value="Pep_deformylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.45.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00163">
        <property type="entry name" value="Pep_deformylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023635">
        <property type="entry name" value="Peptide_deformylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036821">
        <property type="entry name" value="Peptide_deformylase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10458">
        <property type="entry name" value="PTHR10458"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01327">
        <property type="entry name" value="Pep_deformylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004749">
        <property type="entry name" value="Pep_def"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01576">
        <property type="entry name" value="PDEFORMYLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56420">
        <property type="entry name" value="SSF56420"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00079">
        <property type="entry name" value="pept_deformyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" evidence="2">
        <location>
            <position position="147"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="104"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="146"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="150"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN07151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="183" mass="19845" checksum="C94B89B3C8A51BC5" modified="2018-04-25" version="1">MRHGSIPGASGRVRPLTLLGDPVLHTPCEEVTDFGPSLGRLVEDLFATMYAAQGVGLAANQIGESARVFVYDCPDDEDVRHLGHIVNPRLVDADGVVVRGPEGCLSLPGLEAGTPRFDHARVEGVDLRGEPLVVHGTGWFARCLQHECDHLDGRVYTDHVTGWRRRRVLRQAARAPWATGAAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JJX6</accession>
    <name>A0A2M9JJX6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_34830</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000022">
        <property type="protein sequence ID" value="PJN07173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN07173">
        <property type="protein sequence ID" value="PJN07173"/>
        <property type="gene ID" value="CG723_34830"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043917">
        <property type="entry name" value="DUF5753"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19054">
        <property type="entry name" value="DUF5753"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="16"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN07173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="293" mass="31829" checksum="F7278EA831387A14" modified="2018-04-25" version="1">MKHGPAVRRRRLGAELRALRARAGFTSGETARLVGWHQSKVSRIETGRSGVKASDVRLLLDAFEVTDPGIRDLLVALAGSGDDGGQHWWHAYRGLLPPAYRDFISLESQACRVRTVETSVVPGLLQTPDYARAVTRAALDGLPDGQVDALVEVRIARQDVLRSASPLRLSAVLDEAVLRRPVGGPRVMAEQLRHLAAVAKLPHVRLQVLPFTAGEHVGLTGPFVVFSFPNTSDLDVVVLDHLTSSLYLERKEDLKAYTDAFDALRIHALSPGDSLDFIAGIAGAHPPPDSERT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-09-29" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JK07</accession>
    <name>A0A2M9JK07_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ArsR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CG723_35005</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000022">
        <property type="protein sequence ID" value="PJN07201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN07201">
        <property type="protein sequence ID" value="PJN07201"/>
        <property type="gene ID" value="CG723_35005"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000485">
        <property type="entry name" value="AsnC-type_HTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019888">
        <property type="entry name" value="Tscrpt_reg_AsnC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019887">
        <property type="entry name" value="Tscrpt_reg_AsnC/Lrp_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01037">
        <property type="entry name" value="AsnC_trans_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00033">
        <property type="entry name" value="HTHASNC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00344">
        <property type="entry name" value="HTH_ASNC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50956">
        <property type="entry name" value="HTH_ASNC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH asnC-type" evidence="4">
        <location>
            <begin position="10"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PJN07201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="151" mass="16524" checksum="4D857B621CE23852" modified="2018-04-25" version="1">MTGESPYTTDATDWRILDVLQREGRASYAELARAVSMSASAVTERVKRLEEAGVIAGYAAVVVPERIGLPILAFVRLRYPNGHYKPFHDLVEVTPEILEAHHVTGDDCFVIKVAARSMKHLEEVSGRIGALGSVTTSVVYSSPLPRRPLGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JK54</accession>
    <name>A0A2M9JK54_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Isochorismatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_35225</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000022">
        <property type="protein sequence ID" value="PJN07243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN07243">
        <property type="protein sequence ID" value="PJN07243"/>
        <property type="gene ID" value="CG723_35225"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.850">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000868">
        <property type="entry name" value="Isochorismatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036380">
        <property type="entry name" value="Isochorismatase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00857">
        <property type="entry name" value="Isochorismatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52499">
        <property type="entry name" value="SSF52499"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Isochorismatase" evidence="1">
        <location>
            <begin position="36"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN07243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="233" mass="24711" checksum="01E5B8BD5C44D25B" modified="2018-04-25" version="1">MAQWWLISRRSGRLRQGDPVPSYEELAELLDPATAVLLTVECQQGVVGPDSALPELAKEARSSGALGNVARLVAGAHESGVQVLHAVAERRPDGRGANHNGRLFRAAARLPVQQISGTEAVRIAPPVEVADEDIVVRRLHGLSPIAGTDVDALLRNLGCRTLIVTGVSANVAIPNAVFDAVNRGYTVAVPADAIAGVPSDYTPAMIRNTLALVATVTSTQDVLTCWKRPRRGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JKA4</accession>
    <name>A0A2M9JKA4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_34165</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000021">
        <property type="protein sequence ID" value="PJN07301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN07301">
        <property type="protein sequence ID" value="PJN07301"/>
        <property type="gene ID" value="CG723_34165"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="27"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="184"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN07301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="203" mass="22001" checksum="899BDFB18A8759F1" modified="2018-04-25" version="1">MTRLTQPLAVLAAEQKSADVTDWPDRIGWIVGLLLFIALVYWLMRQGWKWRGTLQGDLPPLPTAPSAPGPARLELSGRYHGSTTAGQWLDRIVAHGLGTRSRVELTLTDAGLDVVRPGATDFFIPVAQLREARLDKGIAGKVLTEGGLLIVTWGHGDKLIDSGFRSDHAAEQAEWVESLNNMIDTSSSSSTNSTTITTEGTAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JKC5</accession>
    <name>A0A2M9JKC5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">rRNA cytosine-C5-methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CG723_34230</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CB01635</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000021">
        <property type="protein sequence ID" value="PJN07313.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN07313">
        <property type="protein sequence ID" value="PJN07313"/>
        <property type="gene ID" value="CG723_34230"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001510">
        <property type="term" value="P:RNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.940.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018314">
        <property type="entry name" value="Fmu/NOL1/Nop2p_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001678">
        <property type="entry name" value="MeTrfase_RsmB/NOP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035926">
        <property type="entry name" value="NusB-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006027">
        <property type="entry name" value="NusB_RsmB_TIM44"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023267">
        <property type="entry name" value="RCMT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22807">
        <property type="entry name" value="PTHR22807"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01189">
        <property type="entry name" value="Methyltr_RsmB-F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01029">
        <property type="entry name" value="NusB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02008">
        <property type="entry name" value="RCMTFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48013">
        <property type="entry name" value="SSF48013"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01153">
        <property type="entry name" value="NOL1_NOP2_SUN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51686">
        <property type="entry name" value="SAM_MT_RSMB_NOP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6 9" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4 6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3 6 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SAM_MT_RSMB_NOP" evidence="8">
        <location>
            <begin position="198"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="S-adenosyl-L-methionine binding" evidence="6">
        <location>
            <begin position="304"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="6">
        <location>
            <position position="425"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="329"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="355"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="372"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PJN07313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="488" mass="52500" checksum="B302735D1E02F31C" modified="2018-04-25" version="1">MNDQPGRRPQKSGKPGTPGKQGKPYRRPQKDPVRYLAFEALRAVDERDAYANLVLPPLLRKAREKEGPEKFDARDAALATELVYGTLRRQGTYDAIVAACIDRPLREVDPPVLDVLNMGVHQLLGTRIPTHAAVSASVELARVVLGDGRAKFVNAVLRKVAQDDLDGWVEKVAPPYDEDAEDHLAVVHSHPRWIVSALWDSLGGGRAGIEDLLEADNERPEVTLVARPGRTTADVVLDEVGEDSALPGRWSPYAVRLTEGGEPGSLDPVRTGRAGVQDEGSQLVAIALANAPLEGRDEKWLDGCAGPGGKAAMLAGLASERGAALLAAEKQPHRARLVANALAGNPGPYQVIAADGTRPPWGPGTFDRVLMDVPCTGLGALRRRPEARWRRRPEDLEGFAPLQRSLLTTALDSVRVGGVVGYATCSPHLAETRAVVDDVMKHHPGAELIDARPLLPGVPALGDGPDIQLWPHLHGTDAMYLALIRRTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JKD0</accession>
    <name>A0A2M9JKD0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">LLM class F420-dependent oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_34280</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000021">
        <property type="protein sequence ID" value="PJN07322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN07322">
        <property type="protein sequence ID" value="PJN07322"/>
        <property type="gene ID" value="CG723_34280"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019921">
        <property type="entry name" value="Lucif-like_OxRdtase_Rv2161c"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011251">
        <property type="entry name" value="Luciferase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036661">
        <property type="entry name" value="Luciferase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00296">
        <property type="entry name" value="Bac_luciferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51679">
        <property type="entry name" value="SSF51679"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03619">
        <property type="entry name" value="F420_Rv2161c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bac_luciferase" evidence="1">
        <location>
            <begin position="19"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN07322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="309" mass="33265" checksum="2CC882BAF47BC3E8" modified="2018-04-25" version="1">MATRLGLSLPQMKQYDIGRDIPAVARAAEEIGYESLWVFERILFPEPARQGLYGVPGLPWPDQYRSVADPLVSLTLAAAVTERARLGTSVLVGPLHVPFQLARALASLDAASGGRVVAGIGTGWSHDEYAAASVAPFEKRGQVLDELLDVFEAVWGPDPVSYEGEFTTIAPSVVGPKPAGPIPVLLPANSPKAARRLVDRADGWMPGAAGAEQLAEQWRNLQELAEERGRKEPIQSVLRVNTVYTRDEYKGDDRRPFQGSVAQIVEDLAAHNAVGLEEILIDLQGLVRDADELTDVAAEVFTAARAAGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JKI7</accession>
    <name>A0A2M9JKI7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">5-oxoprolinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CG723_34620</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CB01635</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the oxoprolinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000021">
        <property type="protein sequence ID" value="PJN07385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN07385">
        <property type="protein sequence ID" value="PJN07385"/>
        <property type="gene ID" value="CG723_34620"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008040">
        <property type="entry name" value="Hydant_A_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002821">
        <property type="entry name" value="Hydantoinase_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003692">
        <property type="entry name" value="Hydantoinase_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045079">
        <property type="entry name" value="Oxoprolinase_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11365">
        <property type="entry name" value="PTHR11365"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05378">
        <property type="entry name" value="Hydant_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01968">
        <property type="entry name" value="Hydantoinase_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02538">
        <property type="entry name" value="Hydantoinase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hydant_A_N" evidence="5">
        <location>
            <begin position="6"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="domain" description="Hydantoinase_A" evidence="3">
        <location>
            <begin position="202"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="domain" description="Hydantoinase_B" evidence="4">
        <location>
            <begin position="685"/>
            <end position="1192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1136"/>
            <end position="1159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1180"/>
            <end position="1215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF05378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PJN07385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="1215" mass="130178" checksum="A81670C2A9DB8257" modified="2018-04-25" version="1">MTGWQFWIDRGGTFTDVVARHPGGRLLTHKLLSDNPTRYRDPAVAAIRELLDSEGESGHAHVDSVRMGTTVATNALLERKGERTALVVTRGFRDALRIAYQNRPRIFARRIELPELLHERVIEADERIDAHGAVLTPLDTDALEVLLRQAYDDGIRALAVVCMHSHLYPDHERQIGALAARIGFPQISLSSEVSPLMKLVPRGDTTVVDAYLSPVLRRYVQQVADQLTGVRLMFMQSNGGLTEAGQFRGKDAILSGPAGGIVGMARVSRLAGFDRVIGFDMGGTSTDVSHYAGEYERVFTTQIAGVRLRAPMLDIHTVAAGGGSVLHFDGSRYRVGPDSAGADPGPACYRGGGPLTVTDANVALGRIQPAHFPRVFGPEGDRPLDHTLVRDRFAALAREIRDRTGDDRTPEQVAEGYLQIAVANIANAVKRISVQKGHDVTRYALTTFGGAGGQHACRVADSLGIRTVLVPPMAGVLSALGIGLADTTAMREQSAEAPLEPSAMPHVHKTADDLEGAARAELLAEDVPEDRIRVTRRAQLRYDGTDTTLTVELTDPDTMRAAFEERHRATYSFTLDRPLVVEALSVEATGLTAPPDLSALAPRSAPPAAPETVSLHTGGAWRDVPLHRRDQLPPGESVTGPAIIAESGSTTVVDDGWRAAVTDDGHLIMERAAVTESSDIGTAADPVLLEVFNNLFMSIAEQMGARLESTSQSVNIKERLDFSCALFDPDGSLVANAPHIPVHLGSMGTSVKEVIRRRGTRMRPGDSYAVNDPYHGGTHLPDVTVITPVFDTEGERLLFYVASRGHHAEIGGIAPGSMPAGSRTIDEEGILFDNWLLVEGGSFRETETLRLLTGGPYPSRNPRTNLADLRAQIAANQKGVDEVARMIDHFGLDVVQAYMKHVQDNAEEAVRRVVDALQDGEFAYETDSGATIRVRVTVDREQRGATVDFTGTSPQLATNFNAPFAVVNAAVLYVFRTLVDDDIPLNDGCLRPLHIVVPPGSFLAPEPPAAVVAGNVETSQAITGALYAALGVQAEGSGTMNNVTFGNESHQYYETVASGSGAGDGFHGAPVVQTHMTNSRLTDPEVLEWRLPVLLEEFAVRRGSGGPGRWRGGDGAVRRLRFLEPMTVSTLSQHRRVPPYGMAGGGPGALGTNSVEHPDGTVDRLAGSDSADVLPGDVLVIETPGGGGYGPPPPAGNDNSDSSEAGEETHDLRAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JKY7</accession>
    <name>A0A2M9JKY7_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Phosphoenolpyruvate--glycerone phosphotransferase</fullName>
            <ecNumber evidence="3">2.7.1.121</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CG723_33590</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CB01635</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Component of the dihydroxyacetone kinase complex, which is responsible for the phosphoenolpyruvate (PEP)-dependent phosphorylation of dihydroxyacetone. DhaM serves as the phosphoryl donor. Is phosphorylated by phosphoenolpyruvate in an EI- and HPr-dependent reaction, and a phosphorelay system on histidine residues finally leads to phosphoryl transfer to DhaL and dihydroxyacetone.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>dihydroxyacetone + phosphoenolpyruvate = dihydroxyacetone phosphate + pyruvate</text>
            <dbReference type="Rhea" id="RHEA:18381"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:16016"/>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="EC" id="2.7.1.121"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.121" evidence="3"/>
    <dbReference type="EMBL" id="NNBL01000020">
        <property type="protein sequence ID" value="PJN07437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN07437">
        <property type="protein sequence ID" value="PJN07437"/>
        <property type="gene ID" value="CG723_33590"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047324">
        <property type="term" value="F:phosphoenolpyruvate-glycerone phosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019563">
        <property type="term" value="P:glycerol catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009401">
        <property type="term" value="P:phosphoenolpyruvate-dependent sugar phosphotransferase system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.510">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039643">
        <property type="entry name" value="DhaM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012844">
        <property type="entry name" value="DhaM_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004701">
        <property type="entry name" value="PTS_EIIA_man-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036662">
        <property type="entry name" value="PTS_EIIA_man-typ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38594">
        <property type="entry name" value="PTHR38594"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03610">
        <property type="entry name" value="EIIA-man"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53062">
        <property type="entry name" value="SSF53062"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02364">
        <property type="entry name" value="dha_pts"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51096">
        <property type="entry name" value="PTS_EIIA_TYPE_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PTS EIIA type-4" evidence="5">
        <location>
            <begin position="17"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002788"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PJN07437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="147" mass="13969" checksum="6401EBB7C8DA307C" modified="2018-04-25" version="1">MSEPGGVGSGGSGQEKAVGIVLVSHSRAVAESVAELAKGLAGGGADVPVAPAGGTEDGGLGTSAELISGAARSVDRGAGVAVLTDLGSAVLTVKALLAEGDELPDGARLVDAPFVEGAVAAVVTASAGADLDAVEAAAVEAYTYRKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JLC3</accession>
    <name>A0A2M9JLC3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Preprotein translocase subunit YajC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">yajC</name>
        <name evidence="10" type="ORF">CG723_31890</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CB01635</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the YajC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000018">
        <property type="protein sequence ID" value="PJN07680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN07680">
        <property type="protein sequence ID" value="PJN07680"/>
        <property type="gene ID" value="CG723_31890"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003849">
        <property type="entry name" value="Preprotein_translocase_YajC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33909">
        <property type="entry name" value="PTHR33909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02699">
        <property type="entry name" value="YajC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01323">
        <property type="entry name" value="YajC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00739">
        <property type="entry name" value="yajC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014631256" evidence="9">
        <location>
            <begin position="24"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="92"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="92"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="126"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PJN07680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="166" mass="17547" checksum="A6D9ECBB2C281AAF" modified="2018-04-25" version="1">MNIVTLLPFIVLIGAMFLMTRSAKKKQQAAGQMRDQMQPGSGVRTIGGMYATVKEVHDEMVLLEVAPGVHAVYAKNSIGAVLADDEYNRIVHGTESDDNDDHDALGADGAVVPDDASSLTETDEPADASDDSRIDLDKKDEAAATDVASEADGAEPKKTDGESDAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JLE2</accession>
    <name>A0A2M9JLE2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CG723_31970</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000018">
        <property type="protein sequence ID" value="PJN07696.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN07696">
        <property type="protein sequence ID" value="PJN07696"/>
        <property type="gene ID" value="CG723_31970"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PJN07696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="405" mass="43635" checksum="303A8B30E5F73022" modified="2018-04-25" version="1">MQHRPTDERLRALNTARSHPTDLEGPGPEQVDPVVLNALLDRHGWERRGGATGRYVRWTLPGASGRTSLLVPESRAFPDSDDLLGEALEALERSGSHSAREVLVSLAVPSDEIRWWRDVPAGPAGSAAWPVEEQLRAAARRMLLAAALAARGKAGYYGARHRRPAAASLETVLVGDAPGGRRLTAFVPVAAGRTLAVRLHQALYAAREAIDYRRATGGMDAFDGAVEAGVSHELVEALVALVRGTEGARVGVEWSPAAGVPDECTAGDEPVEFSPGDLTVLREASARYLQSEPSIAVRITGTVVRMRRSRPRGEGTVRLHVIAGADVPHVRMTLDEEAYRTAGHAHLVGLPIRVHGRLESRGGFRRLTGASGVVPVQVEEAERDRLMKSLQENLDFFEEACSGDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JLU1</accession>
    <name>A0A2M9JLU1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GNAT family N-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_32270</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000018">
        <property type="protein sequence ID" value="PJN07747.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN07747">
        <property type="protein sequence ID" value="PJN07747"/>
        <property type="gene ID" value="CG723_32270"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="15"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN07747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="149" mass="16398" checksum="9A2E669C0E5202FF" modified="2018-04-25" version="1">MTDTHATAPALPDGYEISADTARIDAERVHRWLSTDAYWAMDRAREHQDRAIAGSLNFGVYDSASGEQVAYARVVTDHATFAWLCDVYVDRAVRGKNVGTALVAAVRDHLEPLGLRRIMLATQDAHGVYEKVGFAALAEPGNWMALVLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JLU6</accession>
    <name>A0A2M9JLU6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_31060</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000017">
        <property type="protein sequence ID" value="PJN07846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN07846">
        <property type="protein sequence ID" value="PJN07846"/>
        <property type="gene ID" value="CG723_31060"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="45"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN07846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="95" mass="10480" checksum="46A29009CD5D7912" modified="2018-04-25" version="1">MVHVREYVRADGTKVRAHSRWAAGARREMSVLAAIALVVDGFAGTTGSGSADGSTKKVPRPRPTAVYPVKFPDWDRPRPRPTPTVSYPIPWDRSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JM72</accession>
    <name>A0A2M9JM72_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CG723_31275</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000017">
        <property type="protein sequence ID" value="PJN07877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN07877">
        <property type="protein sequence ID" value="PJN07877"/>
        <property type="gene ID" value="CG723_31275"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.490.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018727">
        <property type="entry name" value="DUF2267"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038282">
        <property type="entry name" value="DUF2267_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10025">
        <property type="entry name" value="DUF2267"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PJN07877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="143" mass="15405" checksum="017B850A300D5F50" modified="2018-04-25" version="1">MLPLHEPAAARPGMTFHQLLERIRYEGAYPTRERADDVTRAVLAALGRQLTGDERVDLAACLPTEAARIFAGQIPAQPLTGWGFVKDLAARTEATTATVRWDTGAVLAVIGDLAGPSLLDRILTQLPPGYALLFGRAELTQTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-09-29" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JM85</accession>
    <name>A0A2M9JM85_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_31335</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000017">
        <property type="protein sequence ID" value="PJN07887.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN07887">
        <property type="protein sequence ID" value="PJN07887"/>
        <property type="gene ID" value="CG723_31335"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041413">
        <property type="entry name" value="MLTR_LBD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17765">
        <property type="entry name" value="MLTR_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="36"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN07887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="298" mass="32898" checksum="67F398148DC107A3" modified="2018-04-25" version="1">MDHSTEIREFLRTRRARITPEEAGLTPHPGARRVPGLRREEVAQLAGVSVDYYVRLERGRTQGVSRTVLEAVARALRLDDAERSHLFDLAQPTSARPRRKRPLSPQRVHPTLYQALDAISSPALVLGRRMDVLATNHLGSALYTDFQARPHAERNFLRYLFLDEDARTLYGDHWDKAAAETVATLHLYAGSHPDDPQLTELIGELSLHDEAFRRMWADHDVLAHATGTKHFHHPLVGDLALNYVTLNVAGAPDQSLVILTPEPASPSAEALSILASWTGTAAAASASAPAEDTRDRTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JM92</accession>
    <name>A0A2M9JM92_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Sugar ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CG723_30355</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CB01635</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000016">
        <property type="protein sequence ID" value="PJN08000.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08000">
        <property type="protein sequence ID" value="PJN08000"/>
        <property type="gene ID" value="CG723_30355"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="28"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="88"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="125"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="157"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="199"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="262"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="89"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PJN08000.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="295" mass="32328" checksum="4FD49E7DADE2E9D8" modified="2018-04-25" version="1">MSTTETRAPLAAPAGKARRDPATRARRTLVYVLLTVGLIVTVAPFLWMALSSFKTQRELGASPPVWWPTEWTLDNFRELLDRMDVGQALFNSLLVAVFVTVCNLLFCSMLGYALAKLNFVGKRPIFGVVLGALMVPGNLMLLPMFVMMSGMGLIDSYAALILPFAAGAFGVFLMRQFIQAIPDELLEAARMDGAREWYIFWRIVLPLVKPALATLSIFVFLGSWNNFLWPLVATNDPGKYTLPVALATFATDPTQADGSNGVLMAGAFLVVLPVLLVFVLLQRFFTQGIATAGLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JMB8</accession>
    <name>A0A2M9JMB8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Oligo-1,6-glucosidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_30380</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000016">
        <property type="protein sequence ID" value="PJN08004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08004">
        <property type="protein sequence ID" value="PJN08004"/>
        <property type="gene ID" value="CG723_30380"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.400.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006047">
        <property type="entry name" value="Glyco_hydro_13_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045857">
        <property type="entry name" value="O16G_dom_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00128">
        <property type="entry name" value="Alpha-amylase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00642">
        <property type="entry name" value="Aamy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aamy" evidence="1">
        <location>
            <begin position="18"/>
            <end position="396"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN08004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="527" mass="57705" checksum="2CADCA128095B8EE" modified="2018-04-25" version="1">MTSRRPATEWLADAVLYQIYPQSFADSDGDGIGDFAGAEAKLDHLAWLGVNTVWFNPCFASPFRDAGYDVSDYLTVAPRYGTNDDLVNLVDAARRRGIRVLLDLVAGHTSDEHAWFKASADDPADQRYIWADTETAPPGFVASPGTRSGFYQPNFFESQPALNFGHAHMNADEPWRLPVDAEGPRTNRRALRDIMDHWLSLGLSGFRVDMAASLIKDDPGHVETAKLWRELRGWLDTRHPHAALLSEWGDPATSVPAGFHADFFLQFGSENDGLYLRSLWNNFTGTVSEPWAPQAPYFDASGEGSPRTFLDGWRAARDAIGDAGFIALPTANHDFSRLACGPRTAEQLPAAFAFQLTWPTLPAIYYGDEIGMRYVPGLPDHEGSRLGPRYNRAGSRTPMQWNDTPNAGFSTAPADQLYLPVDPDANRPTVAAQQADPDSLLNLVRRLITLRRATPELGPDGSTEVLHDGYPLSYIRGGRYLVVVNPRGEHADAAAPKDTATPVVASGVTVSGGRISAEGFGYGIFEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JMI5</accession>
    <name>A0A2M9JMI5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_30875</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000016">
        <property type="protein sequence ID" value="PJN08085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08085">
        <property type="protein sequence ID" value="PJN08085"/>
        <property type="gene ID" value="CG723_30875"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="39"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="98"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN08085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="122" mass="13748" checksum="477A65C61B7DA9C9" modified="2018-04-25" version="1">MSNTDPMAGPPHPYDQYQQPPQPPRRPERREGGARRAGLVIHTIADIAAVFLGLWILLYLLEANQDNVFVEFVHGTADWLAWWSQDVFTMDTEGLRVLLNYGLPAVIYLLVGHGIAARLNRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JMP1</accession>
    <name>A0A2M9JMP1_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HATPase_c domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_29485</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000015">
        <property type="protein sequence ID" value="PJN08140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08140">
        <property type="protein sequence ID" value="PJN08140"/>
        <property type="gene ID" value="CG723_29485"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13581">
        <property type="entry name" value="HATPase_c_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HATPase_c" evidence="2">
        <location>
            <begin position="48"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="91"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="91"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN08140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="126" mass="13244" checksum="31A69A1BA8035BCC" modified="2018-04-25" version="1">MTAQQAQPPVTVSVFTRAFPATPLGASLARRSALGRLGDWGVPPGAPLHDTVALLVAELAANAARHGRVPGRNFALRVLYEHESAVVRIEVSDTHSRRPDPSDVGMADPDAEGGRGLALVEAVAHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JMP2</accession>
    <name>A0A2M9JMP2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CG723_29465</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000015">
        <property type="protein sequence ID" value="PJN08136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08136">
        <property type="protein sequence ID" value="PJN08136"/>
        <property type="gene ID" value="CG723_29465"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PJN08136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="151" mass="16953" checksum="CF36F44A3003F262" modified="2018-04-25" version="1">MHHYRSAVLATGARWQISADHLAGLAAECAIKAILIRFLGSELKPNGMPHHPEMKFAHPTRRQRNWDGQHGHLPALWEQLTAVAHRRNDTAAGLLFSQLLWENPFADWNVGDRYCDGTTLTEELVDRHLKAAHDLIAAHEQARILGTGTFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JMU6</accession>
    <name>A0A2M9JMU6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Enoyl-CoA hydratase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_29780</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the enoyl-CoA hydratase/isomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000015">
        <property type="protein sequence ID" value="PJN08196.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08196">
        <property type="protein sequence ID" value="PJN08196"/>
        <property type="gene ID" value="CG723_29780"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.12.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018376">
        <property type="entry name" value="Enoyl-CoA_hyd/isom_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014748">
        <property type="entry name" value="Enoyl-CoA_hydra_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00166">
        <property type="entry name" value="ENOYL_COA_HYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN08196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="267" mass="27961" checksum="63D2FF8D2126B705" modified="2018-04-25" version="1">MADSVLYEVSDGLATITLNRPEAMNAMNTESKVAFRDAAQAAAADGAVRAVLLTAAGDRAFCVGQDLKEHVGSLMADREAGTGRTMNTVREHYNPILRALTQMPKPVVAAVNGVAAGAGFGFALAADYRIVSDTAAFNTSFAGVALTADSGVSWTLPRVVGPGRAADLLLFPRSVKAQEAYELGIANRVVPAGELAEEARKLARSLAEGPTLAYAALKESLAFAAGHTLDESLDKEDELQSRAGASEDHAIAVQAFIAKEKPKYLGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JN57</accession>
    <name>A0A2M9JN57_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Integrin-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CG723_28245</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000014">
        <property type="protein sequence ID" value="PJN08294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08294">
        <property type="protein sequence ID" value="PJN08294"/>
        <property type="gene ID" value="CG723_28245"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008305">
        <property type="term" value="C:integrin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007155">
        <property type="term" value="P:cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007229">
        <property type="term" value="P:integrin-mediated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.130">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013517">
        <property type="entry name" value="FG-GAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013519">
        <property type="entry name" value="Int_alpha_beta-p"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000413">
        <property type="entry name" value="Integrin_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028994">
        <property type="entry name" value="Integrin_alpha_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01839">
        <property type="entry name" value="FG-GAP"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13517">
        <property type="entry name" value="FG-GAP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01185">
        <property type="entry name" value="INTEGRINA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00191">
        <property type="entry name" value="Int_alpha"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69318">
        <property type="entry name" value="SSF69318"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51470">
        <property type="entry name" value="FG_GAP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6" id="KW-0401">Integrin</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014644127" evidence="5">
        <location>
            <begin position="33"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="233"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PJN08294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="474" mass="47486" checksum="4F903A64422EADF2" modified="2018-04-25" version="1">MPLPFRTAVAAATVTALTGGLFAAVTATPASAAPAKYADDFNGDGHRDIAIGAPYKSVNGAGAAGGVVVALGSATGLTTQKVELTQSSAGVPGTPEEGDHFGISIAGGDLDSDGYADLVVGSDGEDVGSYEGQGSVTILWGGAKPFTSSTTTTVDNPHQWQSHGLDVAVGDFTGDSGADLAVIEPDAVVIYKGGNSRESQTTPAYTMTVPGAQLLNWEAAVGDVNGDGKDDLAVTGDPGTGRPGTDIYTGQEGRPNRIQRVDDGGTAVALGDINGDGFDDMATSLTWPGSYSVTDPSNGSGYVTVRYGSRTGFGDPTTLHQNSTGVPGADEDGDNWGSSVAIGDITGDGKAELVVGANGEWLGNLKNAGDVTVFRGSASGVSQSGVVRISQDTTGVPGAAETDDLFGAQVRIADYNNNGKADLAVTASFENNRSGGLWTLPGTSSGLTGSGSKSLSSADFGLASGSRLGESLLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JNA6</accession>
    <name>A0A2M9JNA6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">GntR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CG723_28580</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000014">
        <property type="protein sequence ID" value="PJN08346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08346">
        <property type="protein sequence ID" value="PJN08346"/>
        <property type="gene ID" value="CG723_28580"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07377">
        <property type="entry name" value="WHTH_GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.530">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011711">
        <property type="entry name" value="GntR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008920">
        <property type="entry name" value="TF_FadR/GntR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07729">
        <property type="entry name" value="FCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
        <property type="entry name" value="GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00895">
        <property type="entry name" value="FCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00345">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48008">
        <property type="entry name" value="SSF48008"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50949">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH gntR-type" evidence="4">
        <location>
            <begin position="13"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PJN08346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="228" mass="24857" checksum="550575D76D78105A" modified="2018-04-25" version="1">MPGTDGGAAVQRSTLRQQIADALRDEILAGRLEPGQEFTVKEIAEQYGVSATPVREALVDLSGQGLLDSAQHRGFAVHEYSLADYRGMIEARSLVTDGIFRGLAANADAHHVTPAALAGVRRRGEEAARAATAGDLNVLIGYDLRFWRELSALFGNPYLSDFFHRLRVQSWMCAVPHLRRVDDLRGHLWAGHCGLVDALADRDARAAQDIVTAYNADSLALVERLAAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JNH7</accession>
    <name>A0A2M9JNH7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_29030</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000014">
        <property type="protein sequence ID" value="PJN08422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08422">
        <property type="protein sequence ID" value="PJN08422"/>
        <property type="gene ID" value="CG723_29030"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="48"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="90"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="114"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="139"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN08422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="166" mass="17143" checksum="1786E304D759EE23" modified="2018-04-25" version="1">MSETPTTPTPPPGPDAGHGVWSDKHRSAGPDPTRGDGAGSGWASGGTVFAGVLMMVGGILGILNGIAGIAKDDVYARIGTYTYAFNLTTWGWIHLIIGVIVAVTGFGVLKGAGWARGVGVAIAALYIIAYFMFLPYEPIWSVIAIAIGVFVIWALVSDGSHDAARA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JNS9</accession>
    <name>A0A2M9JNS9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">3-hydroxy-3-methylglutaryl-ACP synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CG723_27475</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CB01635</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the thiolase-like superfamily. HMG-CoA synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000013">
        <property type="protein sequence ID" value="PJN08523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08523">
        <property type="protein sequence ID" value="PJN08523"/>
        <property type="gene ID" value="CG723_27475"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004421">
        <property type="term" value="F:hydroxymethylglutaryl-CoA synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006084">
        <property type="term" value="P:acetyl-CoA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010142">
        <property type="term" value="P:farnesyl diphosphate biosynthetic process, mevalonate pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013746">
        <property type="entry name" value="HMG_CoA_synt_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013528">
        <property type="entry name" value="HMG_CoA_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08540">
        <property type="entry name" value="HMG_CoA_synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01154">
        <property type="entry name" value="HMG_CoA_synt_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HMG_CoA_synt_N" evidence="2">
        <location>
            <begin position="85"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="domain" description="HMG_CoA_synt_C" evidence="3">
        <location>
            <begin position="274"/>
            <end position="370"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PJN08523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="416" mass="45051" checksum="ED4935D86EDEE347" modified="2018-04-25" version="1">MTATGAGQAYGIEALNVWCGLARLTAADLFAGRGLDPERLDNLMMSERSIGLPIEDPVTNAVNAARPLIEALPPEERARIELVVTSTESGVDYSKSLTSYVHKYLGLNRHCRLIEVKQACFGATAAVQTAVGYLASGISPGAKALVIATDVAVVDEKAEYSEPAAGHGAAAMLLSDRPRVLAMDLGAFGNYSYETLDSARPSPRFDIADVDRSLFAYLDCLKNAYADYAARVTDVDFTRDFDHLVMHTPFAGLVKAGHRKMMREQGVTGPRIDEDFARRVAPSLIYPGAVGNLCSGSVYLALASLLDSGVVTAPSRVGLFSYGSGCSSEFFSGIVDEQSAATVAEQGIGKRLEARARITFDEYLAVLEHNLECLVPVENRTVDPAEWEPLLDRVGDRPEILTFTGVKDYHRQYAWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JP07</accession>
    <name>A0A2M9JP07_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CG723_27805</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CB01635</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">In the C-terminal section; belongs to the transposase 35 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000013">
        <property type="protein sequence ID" value="PJN08575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08575">
        <property type="protein sequence ID" value="PJN08575"/>
        <property type="gene ID" value="CG723_27805"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032196">
        <property type="term" value="P:transposition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001959">
        <property type="entry name" value="Transposase_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010095">
        <property type="entry name" value="Transposase_IS605_OrfB_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01385">
        <property type="entry name" value="OrfB_IS605"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07282">
        <property type="entry name" value="OrfB_Zn_ribbon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0815">Transposition</keyword>
    <feature type="domain" description="OrfB_IS605" evidence="6">
        <location>
            <begin position="190"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="domain" description="OrfB_Zn_ribbon" evidence="7">
        <location>
            <begin position="318"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="211"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF07282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PJN08575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="390" mass="43363" checksum="E0060ED225071020" modified="2018-04-25" version="1">MTTEATTQAAGHCRYTYRVRLSASARTALEAEWDRARWVWNECVAKSKAVHAHNRATGEKTTCGPVQLAAMLTEARSRTPWLADGACVPQQQLIRDFGKSRAKALKDIKARLPMRQRAGMPKYKKKREALPTLEYTKRGFRLKDGRLHLAGQIVVRPVWSRELPEPPSSVRVYRDAVGHWWASFVVPAQTEKLPATGRVIGIDWGVKETATTTSDDHDLPHSQHGRTAGQKLARYQRMMARRRPAKGQAASKGYREAKRQRAKLHRKVAAQRQDTSRKWAKKVVRDHDALAIEDFKPKFLAKSTMAGKAADAAIGATKAALVEMARKHGRTIHVVHPAHTTMDCAQCGARTKHALPLSERTYACTACGAVSPRDKNSARVMLVRAGLPPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JQ57</accession>
    <name>A0A2M9JQ57_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HTH tetR-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_25330</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000011">
        <property type="protein sequence ID" value="PJN09009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN09009">
        <property type="protein sequence ID" value="PJN09009"/>
        <property type="gene ID" value="CG723_25330"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="68"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="89"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN09009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="259" mass="27190" checksum="937C440FED33D5C8" modified="2018-04-25" version="1">MTRRIPLPPSGALGPRSPRVHVSTDIAQHCAITQRCAIYVIAQHCAKPHVNGVGSGVQNERVTSGRADTNRRRILDVALAELLRDPDASMDQIARAAGVVRRTVYGHFPSREALVAALVDDAVVAVEAAQSAGRAGVTDPAEAVARSLLAVWEVADRYRLLVALAQRAVTVEGIRARLTPVRDSCAELLQQGLESGEFASPLPATALAYVHEQVLFGLLEAVNDGLIPAEEAGHSAAVTVLTAAGVPASRATELVAGLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JRE7</accession>
    <name>A0A2M9JRE7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Enoyl-CoA hydratase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_22020</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the enoyl-CoA hydratase/isomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000008">
        <property type="protein sequence ID" value="PJN09456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN09456">
        <property type="protein sequence ID" value="PJN09456"/>
        <property type="gene ID" value="CG723_22020"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.12.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018376">
        <property type="entry name" value="Enoyl-CoA_hyd/isom_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014748">
        <property type="entry name" value="Enoyl-CoA_hydra_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00166">
        <property type="entry name" value="ENOYL_COA_HYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN09456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="261" mass="27626" checksum="A8D2DC9CC72DB1EA" modified="2018-04-25" version="1">MTTKPTTDAPTVHTEERDGVFVITIDRPKARNAVDGATARALADAFDQLDARDDLMVGVLTGAGGTFSAGMDLKAFAKGDTPVIPGRGFAGLTRTQLRTPLIAAVEGWALGGGTEMALACDLIVAAQDATFGLSEVTFGLVPPEGGIVRLPERIPRNIAVEILLTGDPLPAERAHQLGLVNHLTPPGETLTKAVEVAHRIARNAPLSIAAVKRAVNERTAYGDQDAFRQQDQLVAPVLASHDAQEGAHAFAEKRPPHWESR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JRI7</accession>
    <name>A0A2M9JRI7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CG723_22335</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CB01635</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000008">
        <property type="protein sequence ID" value="PJN09501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN09501">
        <property type="protein sequence ID" value="PJN09501"/>
        <property type="gene ID" value="CG723_22335"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003838">
        <property type="entry name" value="ABC3_permease_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02687">
        <property type="entry name" value="FtsX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="316"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="365"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="444"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="domain" description="FtsX" evidence="8">
        <location>
            <begin position="344"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="401"/>
            <end position="435"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PJN09501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="479" mass="50011" checksum="017D52B0D218ECFB" modified="2018-04-25" version="1">MNLFKRAWWRLRGHLGKTVMLVGLFFVICTLVLSGFLIRSAAARAADSAKGNVGVVATMQLDVDALINSGGGSAGDGAQPGLIGSKGDLHSKLVDKICKSSVVAQCNYTVDSGAAPTRRLKLHQPVPAPTGQDTTGTDLFKASGVRDLDSVKGFHNGDSKILSGSGLKRDSKSDMIVIEERVAEDNRLKVGDKIKLRVGEIDPGKGGMSTKEVEFTVGGIYKNDTADTGSYVPAVADPSNQIYVTPEGATRLQGKEPAAGGAALREATFALRNPDDLGKLKDDAKAAGADLEIFPISVNDKQYKALVGPINKTADFASLTVWLVAIAGTVILALIIASNMRERRKELGILLSLGEKKPKLLGQHLVEVVACAVLAIGFAATGSQFIAQGIGDQLLSSQVSSAEDSAADQGPQKDPSDPNGLKKQDTPQSKPIDSMDIELGAGDIGAVGATGLGIAALATIVPGTRILRLDPRDILTKGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JRS8</accession>
    <name>A0A2M9JRS8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_22740</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000008">
        <property type="protein sequence ID" value="PJN09558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN09558">
        <property type="protein sequence ID" value="PJN09558"/>
        <property type="gene ID" value="CG723_22740"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD_binding_3" evidence="1">
        <location>
            <begin position="3"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="domain" description="FAD_binding_3" evidence="1">
        <location>
            <begin position="280"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN09558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="374" mass="39953" checksum="309895F1C3A2965B" modified="2018-04-25" version="1">MRIAIAGGGLGGLTLARILHQHGIDAVVYEREASRSARPQGGALDLHPESGQLALAEAGLAGRFRSEARPEGEEHRIVDPTGRTLVHHEPQPGSFSGRPEIDRSALRDLLLDSLPGDTVVWRHRLVAATPRPGGGWELTFHGGHRTGCDILIGADGARSIVRSLLADVQLSSVATLVELNIEDVNRRYPDLAELVGPGNLWCVGVNQILAAQRLGDGSLRVGISLRADDRPIDTYRSKRALLDVFGGWDPRLTALIEAGDSAPTPRPIEAMPTGTRWSSRPGVTLIGDAAHLMPPVGEGANQAMLDAAELAGRLAANPADPDSAIRTYEEVMFTRIHPIAEMSARVQAMMLSPTAAEDIVRFFTARPAEPASAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JRY6</accession>
    <name>A0A2M9JRY6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_20740</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000007">
        <property type="protein sequence ID" value="PJN09645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN09645">
        <property type="protein sequence ID" value="PJN09645"/>
        <property type="gene ID" value="CG723_20740"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045684">
        <property type="entry name" value="DUF6191"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19690">
        <property type="entry name" value="DUF6191"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="20"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN09645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="116" mass="12509" checksum="E6F99EC2777C019F" modified="2018-04-25" version="1">MRFRPPGGAVFNMFEELFSPGRKHTNEERKRLELTRVDLNDGDPGRGPIDLTSGKVLVRVPNQTPPDPTEGPETAATEPPESAPEASATPTTDPGRDPGHDSAHDPDPTDPSDDET</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JS18</accession>
    <name>A0A2M9JS18_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_20945</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000007">
        <property type="protein sequence ID" value="PJN09680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN09680">
        <property type="protein sequence ID" value="PJN09680"/>
        <property type="gene ID" value="CG723_20945"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007995">
        <property type="entry name" value="DUF742"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36221">
        <property type="entry name" value="PTHR36221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05331">
        <property type="entry name" value="DUF742"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="41"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN09680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="196" mass="20931" checksum="5D269654CA5F1A81" modified="2018-04-25" version="1">MAGSATPPSGSSANWSYGPGQGQGQGDAPNRYNFPSAPSHRRQPYAPPHPPQPRQPGPYDQPSAPRIQPVQPQRRPDSPAPAANNPLVRPYAMTGGRTRPRYQLAIEALVHTTAQPHQLQGQLPEHQRICTLCREIKSVAEVSALLSIPLGVARILVADLAEAGLVAIHQPGGEENAGGQPDVTLLERVLSGLRKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JSF4</accession>
    <name>A0A2M9JSF4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CG723_21690</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CB01635</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000007">
        <property type="protein sequence ID" value="PJN09809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN09809">
        <property type="protein sequence ID" value="PJN09809"/>
        <property type="gene ID" value="CG723_21690"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025966">
        <property type="entry name" value="OppC_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12911">
        <property type="entry name" value="OppC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="47"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="110"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="143"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="170"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="225"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="278"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="108"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PJN09809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="314" mass="33258" checksum="81A2BDFD043C3312" modified="2018-04-25" version="1">MTADTNDLDTAQLPPPAEKSARALARARKRRSAARFWREYRTHRSGLWGLAGLILIALIAICAPLLVGADSQSVTDAPGGALEAPSGEFPLGTDQFGRSVLALLVWGARVSLTVGLLAAFLCVAIGTVVGIVAGHFRGWYSTVLMRVTDWFLVMPTLVLAIALATVMSRSIWTVILAIGVTTWPTTARLVRAQTLAVESRPYIERARALGGGHGHIMLRHVLPNVMPLVLAQTTLVISSAILTEATLAFLGLGDPTITSWGGMLQDAREAGAVSAGDWWYLAPPGLAIALVALAFTLCGRAIEAVLNPKLGVAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JSL2</accession>
    <name>A0A2M9JSL2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Peptidase M16</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CG723_21865</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CB01635</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the peptidase M16 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000007">
        <property type="protein sequence ID" value="PJN09838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN09838">
        <property type="protein sequence ID" value="PJN09838"/>
        <property type="gene ID" value="CG723_21865"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011249">
        <property type="entry name" value="Metalloenz_LuxS/M16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011765">
        <property type="entry name" value="Pept_M16_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001431">
        <property type="entry name" value="Pept_M16_Zn_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007863">
        <property type="entry name" value="Peptidase_M16_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00675">
        <property type="entry name" value="Peptidase_M16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05193">
        <property type="entry name" value="Peptidase_M16_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63411">
        <property type="entry name" value="SSF63411"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00143">
        <property type="entry name" value="INSULINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase_M16" evidence="3">
        <location>
            <begin position="45"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M16_C" evidence="4">
        <location>
            <begin position="199"/>
            <end position="380"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU004447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF05193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PJN09838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="459" mass="49563" checksum="1C339F0A170EC95F" modified="2018-04-25" version="1">MTSRSSKATARTSSEARAVARTQTLIKGENGIGTVRRTTLPGGLRIVTETLPSVRSATFGIWANVGSRDETPTLNGATHYLEHLLFKGTSRRSALDISSTIDAVGGEMNAFTAKEYTCYYARVLDTDLPLAIDVVCDMLTGSLIEEADVDAERGVILEEIAMTEDDPGDCVHDLFAHTMLGDTPLGRPVLGTVDTINALNRGQIARFYKKHYDPTHLVVAAAGNVDHNKVVRQVRAAFEKAGALTRTDAVPMAPRDGRKPVRAAGRMELLGRKTEQAHVILGMPGLARTDERRWAMGVLNTALGGGMSSRLFQEVREKRGLAYSVYSYTSGFADCGLFGVYAGCRPSQVHDVLKICRDELTHVAEHGLSDDEIGRAIGQLSGSTVLGLEDTGALMNRIGKSELCWGEQMSVSDMLEEISSVTPDEVRAVARDILGQRPSLSVIGPLKDKQAARLHEAVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JSQ2</accession>
    <name>A0A2M9JSQ2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_19385</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000006">
        <property type="protein sequence ID" value="PJN09906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN09906">
        <property type="protein sequence ID" value="PJN09906"/>
        <property type="gene ID" value="CG723_19385"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="249"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN09906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="299" mass="33296" checksum="0BE37A4134391F84" modified="2018-04-25" version="1">MTAVHTTARRPIDLDDVPGWFPPLDQLLFTWLLERQAQREVRGDLLELGVYMGKSAVLLGQHLHGTEKFTVCDLFEGDAPDEANQAESTKSYASLTRQAFEENYLSFHDELPKVVQAPSSVISDEVDPGTCRFVHIDASHLYEHVYGDIGAARELLGADGIVVLDDFRSEHTPGVSVAAWEAVLNRGLRPLCLSTQKLYATWEDPEPLQDELLGMLRERDDIALSVQQAAGHRLVRTKSKAVKAPAFPRSRHHVEHLAEPKAASAPDPAPVRKRSRARRIAVDLTPPVITRALRRARRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JSZ7</accession>
    <name>A0A2M9JSZ7_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">tRNA N6-adenosine threonylcarbamoyltransferase</fullName>
            <ecNumber evidence="6">2.3.1.234</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">N6-L-threonylcarbamoyladenine synthase</fullName>
            <shortName evidence="6">t(6)A synthase</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">t(6)A37 threonylcarbamoyladenosine biosynthesis protein TsaD</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">tRNA threonylcarbamoyladenosine biosynthesis protein TsaD</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6 9" type="primary">tsaD</name>
        <name evidence="9" type="ORF">CG723_20085</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CB01635</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>adenosine(37) in tRNA + L-threonylcarbamoyladenylate = AMP + H(+) + N(6)-L-threonylcarbamoyladenosine(37) in tRNA</text>
            <dbReference type="Rhea" id="RHEA:37059"/>
            <dbReference type="Rhea" id="RHEA-COMP:10162"/>
            <dbReference type="Rhea" id="RHEA-COMP:10163"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:73682"/>
            <dbReference type="ChEBI" id="CHEBI:74411"/>
            <dbReference type="ChEBI" id="CHEBI:74418"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.3.1.234"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <text evidence="6">Binds 1 Fe(2+) ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the KAE1 / TsaD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.234" evidence="6"/>
    <dbReference type="EMBL" id="NNBL01000006">
        <property type="protein sequence ID" value="PJN10021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN10021">
        <property type="protein sequence ID" value="PJN10021"/>
        <property type="gene ID" value="CG723_20085"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061711">
        <property type="term" value="F:N(6)-L-threonylcarbamoyladenine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002949">
        <property type="term" value="P:tRNA threonylcarbamoyladenosine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01445">
        <property type="entry name" value="TsaD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000905">
        <property type="entry name" value="Gcp-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017861">
        <property type="entry name" value="KAE1/TsaD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017860">
        <property type="entry name" value="Peptidase_M22_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022450">
        <property type="entry name" value="TsaD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11735">
        <property type="entry name" value="PTHR11735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11735:SF6">
        <property type="entry name" value="PTHR11735:SF6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00814">
        <property type="entry name" value="TsaD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00789">
        <property type="entry name" value="OSIALOPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00329">
        <property type="entry name" value="gcp_kae1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03723">
        <property type="entry name" value="T6A_TsaD_YgjD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01016">
        <property type="entry name" value="GLYCOPROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="4 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6 9" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 6" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="TsaD" evidence="8">
        <location>
            <begin position="27"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="6">
        <location>
            <begin position="137"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="343"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="346"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="114"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="118"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="171"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="184"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="188"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="280"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="308"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PJN10021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="365" mass="38020" checksum="3D11E40C8C095D19" modified="2018-04-25" version="1">MADEPLVLGIETSCDETGVGIVRGHTLLADAVASSVDEHARFGGVVPEVASRAHLEAMVPTIERALKDAGVAASDLDGISVTAGPGLAGALLVGVSAAKAFAYALGKPLYGVNHLASHICVDQLEHGPLPEPTMALLVSGGHSSLLLSSDITSDVRPLGATIDDAAGEAFDKIARVLNLGFPGGPVIDRYAKEGDPNAITFPRGLTGPRDPAYDFSFSGLKTSVARWIEAKRAAGEDVPVRDVSASFQEAVVDVLTRKAVRACKDEGVDHLMIGGGVAANSRLRALAQERCEAAGIRLRVPRPKLCTDNGAMVAALGAEMVARNRSASAWDLSADSSLPVTETHVPGQTHDHDHVHEVAKDNLYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JT64</accession>
    <name>A0A2M9JT64_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 7 8">Elongation factor Tu</fullName>
            <shortName evidence="7">EF-Tu</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7 10" type="primary">tuf</name>
        <name evidence="10" type="ORF">CG723_20400</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CB01635</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000006">
        <property type="protein sequence ID" value="PJN10075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN10075">
        <property type="protein sequence ID" value="PJN10075"/>
        <property type="gene ID" value="CG723_20400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01884">
        <property type="entry name" value="EF_Tu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03697">
        <property type="entry name" value="EFTU_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00118_B">
        <property type="entry name" value="EF_Tu_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041709">
        <property type="entry name" value="EF-Tu_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004161">
        <property type="entry name" value="EFTu-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033720">
        <property type="entry name" value="EFTU_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031157">
        <property type="entry name" value="G_TR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009001">
        <property type="entry name" value="Transl_elong_EF1A/Init_IF2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004541">
        <property type="entry name" value="Transl_elong_EFTu/EF1A_bac/org"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004160">
        <property type="entry name" value="Transl_elong_EFTu/EF1A_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03144">
        <property type="entry name" value="GTP_EFTU_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03143">
        <property type="entry name" value="GTP_EFTU_D3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="SSF50447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50465">
        <property type="entry name" value="SSF50465"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00485">
        <property type="entry name" value="EF-Tu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00301">
        <property type="entry name" value="G_TR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 7 10" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="5 7" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4 7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="9">
        <location>
            <begin position="10"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="19"/>
            <end position="26"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="83"/>
            <end position="87"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="138"/>
            <end position="141"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00029554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PJN10075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="397" mass="43695" checksum="CC9F950B4F62FF7E" modified="2018-04-25" version="1">MAKAKFERTKPHVNIGTIGHIDHGKTTLTAAITKVLHDAYPDLNEASAFDQIDKAPEERQRGITISIAHVEYQTETRHYAHVDCPGHADYIKNMITGAAQMDGAILVVAATDGPMPQTKEHVLLARQVGVPYIVVALNKADMVDDEEILELVELEVRELLSEYEFPGDDLPVVKVSALKALEGDKEWGQSILNLMAAVDESIPQPERDVDKPFLMPIEDVFTITGRGTVVTGRIERGVLKVNETVDIVGIKTEKTTTTVTGIEMFRKLLDEGQAGENVGLLLRGIKREDVERGQVIIKPGSVTPHTEFEAQAYILSKDEGGRHTPFFNNYRPQFYFRTTDVTGVVTLPEGTEMVMPGDNTEMNVALIQPVAMEEGLKFAIREGGRTVGAGQVTKIVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JTG7</accession>
    <name>A0A2M9JTG7_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">30S ribosomal protein S7</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">rpsG</name>
        <name evidence="10" type="ORF">CG723_20410</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CB01635</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Part of the 30S ribosomal subunit. Contacts proteins S9 and S11.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6 7">Belongs to the universal ribosomal protein uS7 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000006">
        <property type="protein sequence ID" value="PJN10077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN10077">
        <property type="protein sequence ID" value="PJN10077"/>
        <property type="gene ID" value="CG723_20410"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.455.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00480_B">
        <property type="entry name" value="Ribosomal_S7_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000235">
        <property type="entry name" value="Ribosomal_S5/S7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005717">
        <property type="entry name" value="Ribosomal_S7_bac/org-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020606">
        <property type="entry name" value="Ribosomal_S7_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023798">
        <property type="entry name" value="Ribosomal_S7_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036823">
        <property type="entry name" value="Ribosomal_S7_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11205">
        <property type="entry name" value="PTHR11205"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00177">
        <property type="entry name" value="Ribosomal_S7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002122">
        <property type="entry name" value="RPS7p_RPS7a_RPS5e_RPS7o"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47973">
        <property type="entry name" value="SSF47973"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01029">
        <property type="entry name" value="rpsG_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00052">
        <property type="entry name" value="RIBOSOMAL_S7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6 7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 6 7" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3 6 8" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 6 8" id="KW-0699">rRNA-binding</keyword>
    <keyword evidence="6" id="KW-0820">tRNA-binding</keyword>
    <feature type="domain" description="Ribosomal_S7" evidence="9">
        <location>
            <begin position="1"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003620"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PJN10077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="156" mass="17404" checksum="17089C67ACC9DB5E" modified="2018-04-25" version="1">MPRKGPAPKRPVIIDPVYGSPLVTSLINKVLLNGKRSTAERIVYGAMEGLREKTGNDPVITLKRALENIKPTLEVKSRRVGGATYQVPIEVKPGRASTLALRWLVGYSRARREKTMTERLLNELLDASNGLGAAVKKREDTHKMAESNKAFAHYRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-09-29" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JTW7</accession>
    <name>A0A2M9JTW7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CG723_18325</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000005">
        <property type="protein sequence ID" value="PJN10336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN10336">
        <property type="protein sequence ID" value="PJN10336"/>
        <property type="gene ID" value="CG723_18325"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022324">
        <property type="entry name" value="Bacilysin_exporter_BacE_put"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010290">
        <property type="entry name" value="TM_effector"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05977">
        <property type="entry name" value="MFS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01988">
        <property type="entry name" value="EXPORTERBACE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014696114" evidence="3">
        <location>
            <begin position="34"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="49"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="75"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="170"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="215"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="253"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="280"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="306"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="397"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="401"/>
            <end position="432"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PJN10336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="432" mass="44502" checksum="52C52BFADAEBB970" modified="2018-04-25" version="1">MRSSLLQQAAFRSFFAGRLVSLLGSSMAPVALAFAVLDASGSGHDLGVVLAAHMLPMLAFLLVGGAVADRFPRRTVLVAAHLGAALTQGAVAALLLTGHYSLPLVTALEFANGVLGAFTTPALRGVVPQLVAKSLLRQANSLLGSARNATKILGPSLSGVLVVTVGSGPAIAFDALTYLVAAGFLARLSLTGTPEASQRDTVLGDIRDGWSAFRAIRWVLVGTLSFCLLNLVQTGTWQILGPQLTRQLSGETTWGFVLSVRGAGMLASSLLMYRMTVRHLLRFGQLAGALGALPLLALGAQGHAPWLILAAFVAGLGSSVTAVAWDTSLQEHVPAHVLSRVASYDDLLSYLAIPVGQLCVGPLAETFGAFRVTAAAGAVSAAASLIPLASRAVRRLPHAQPDTSAPTTPTAPGAPVTPATQKSPESTHRAPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JU13</accession>
    <name>A0A2M9JU13_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CG723_18640</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000005">
        <property type="protein sequence ID" value="PJN10386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN10386">
        <property type="protein sequence ID" value="PJN10386"/>
        <property type="gene ID" value="CG723_18640"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001451">
        <property type="entry name" value="Hexapep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00132">
        <property type="entry name" value="Hexapep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="SSF51161"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PJN10386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="215" mass="23473" checksum="7BA155A64293D799" modified="2018-04-25" version="1">MSLVPADPTVLHPMPGQSRVVLLKPLVTSPLIEVGAFSYYDDPDDPTAFETRNVLYHYGPEKLVIGKFCALGEGVRFIMNGANHRMDGPSTFPFPIMGGSWADHFDLISGLPGRGDTVVGNDVWFGYRTTVMPGVRIGHGAIIASGSVVVDDVPDYGIVGGNPAKLIRRRHSDEDVERLLSLAWWDWPTEHLTEHVRTVMSGSVDALEAVAPKPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JUK7</accession>
    <name>A0A2M9JUK7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CG723_19125</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CB01635</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000005">
        <property type="protein sequence ID" value="PJN10467.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN10467">
        <property type="protein sequence ID" value="PJN10467"/>
        <property type="gene ID" value="CG723_19125"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001851">
        <property type="entry name" value="ABC_transp_permease"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02653">
        <property type="entry name" value="BPD_transp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="50"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="76"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="101"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="128"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="172"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="221"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="302"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PJN10467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="336" mass="34027" checksum="51BC3515F459ED7C" modified="2018-04-25" version="1">MTAANPTAALYKRVARSLGAGAPVYVLLAVLLVALAATDPGFYEPERFLAFVKRAAPLVILAAGQYLVIVCGEFDLSVGAVVTAGVVVAAELYGSYPGASWIVVTGGLLLAGALTGLVSGLITTKLRVPSFITTLGMMLILEGAVFFWTGGSPHGSLPEEFRRLGRGTAGGWLPWAVLACLVAGAAAVFLMRSDFGRTLIATGDSERTAALAGVRVHRARIIAFVLSGVAAALAAVLVGGFSGVSAQAGRGYEFEAITAVVLGGVALGGGRGSVVAAMAGAFSLQALFTLLNLQGVSGALESTVQGVIVIAAVGLGAADFSRLRRRRTHPSGGTPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JUY5</accession>
    <name>A0A2M9JUY5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CG723_15875</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000004">
        <property type="protein sequence ID" value="PJN10680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN10680">
        <property type="protein sequence ID" value="PJN10680"/>
        <property type="gene ID" value="CG723_15875"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PJN10680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="117" mass="13237" checksum="DF10661FD24DAE79" modified="2018-04-25" version="1">MAEPERARTERRMRPAPLLFEPAEAAADPEHFFGLEAIEDPRELLARATELALAFRAATDRSVEFQALAAAQLADPRRFDRLTPAAIAERAQWTEDYAKKMVEFGRDLMRGPAENRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JUZ6</accession>
    <name>A0A2M9JUZ6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="11">PTS sugar transporter subunit IIA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CG723_15375</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CB01635</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000004">
        <property type="protein sequence ID" value="PJN10597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN10597">
        <property type="protein sequence ID" value="PJN10597"/>
        <property type="gene ID" value="CG723_15375"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008982">
        <property type="term" value="F:protein-N(PI)-phosphohistidine-sugar phosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009401">
        <property type="term" value="P:phosphoenolpyruvate-dependent sugar phosphotransferase system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003352">
        <property type="entry name" value="PTS_EIIC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013013">
        <property type="entry name" value="PTS_EIIC_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02378">
        <property type="entry name" value="PTS_EIIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51103">
        <property type="entry name" value="PTS_EIIC_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0598">Phosphotransferase system</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="6 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="29"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="66"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="98"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="137"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="177"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="272"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="322"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="377"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="domain" description="PTS EIIC type-1" evidence="10">
        <location>
            <begin position="16"/>
            <end position="408"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PJN10597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="421" mass="44275" checksum="49FE64EE0EC48457" modified="2018-04-25" version="1">MTTASAAPAAAKKKGAGAMAVMQRIGRSLMLPVAVLPAAALLVRFGQPDMLGKDSFPTFITKLASYMSAGGGALLDNMPLLFCVGIAIGFAKKSDGSTALAAVTGYLVFQKVLATFTDSNLPKVAAVVDGKIVMNEAPVNAGVLGGVVMGVVVALLYQKFYRTKLPDWAGFFGGRRLVPILSAFAGLVIGIVFGLIWPVLGAGLHNFGEWLVGSGAVGAGIFGVANRALIPIGMHHLLNSFPWFQAGTYEGKSGDIARFLQGDPSAGQFMTGFFPIMMFALPAACLAIVHCARPERRKVVGGMMFSLAATAFVTGVTEPIEFTFMFIAPALYAIHAVLTGVSMALTWGLGMKDGFGFSAGAVDYFLNLGIATNPWGLALVGLCFAVVYYVIFRFAITKFNIPTPGRESDEELAEILKAESK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-06-02" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JVJ6</accession>
    <name>A0A2M9JVJ6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_15125</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000004">
        <property type="protein sequence ID" value="PJN10915.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN10915">
        <property type="protein sequence ID" value="PJN10915"/>
        <property type="gene ID" value="CG723_15125"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="121"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="121"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="154"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN10915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="178" mass="18758" checksum="BD6C72FCA400FC9C" modified="2018-04-25" version="1">MGAAQAAVGDIVTELESFTKFQQRVDQLIKDLKGSDAGPQKIGQEPLSRHQFGGGAAGWGAADGLFTSYQTVLTELEKLSKVLSDSIEGMGIAVLASHKGYANIDVDIRDRMAAISAETKDHYGGDYDPEKSRLWHHGEGPKMDEIGTEDTKGKSGDAGTSSPKPESTPSAGNKHGAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JVQ2</accession>
    <name>A0A2M9JVQ2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="10">ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CG723_16115</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000004">
        <property type="protein sequence ID" value="PJN10939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN10939">
        <property type="protein sequence ID" value="PJN10939"/>
        <property type="gene ID" value="CG723_16115"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221">
        <property type="entry name" value="PTHR24221"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="SSF90123"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="28"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="65"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="137"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="164"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="250"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="280"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="680"/>
            <end position="701"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="713"/>
            <end position="734"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="790"/>
            <end position="814"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="820"/>
            <end position="838"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="899"/>
            <end position="923"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="9">
        <location>
            <begin position="29"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="8">
        <location>
            <begin position="342"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="9">
        <location>
            <begin position="681"/>
            <end position="963"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="8">
        <location>
            <begin position="997"/>
            <end position="1234"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="376"/>
            <end position="383"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="1033"/>
            <end position="1040"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PJN10939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="1249" mass="134272" checksum="DD7C14717C758914" modified="2018-04-25" version="1">MAVPPVRAEPRTWGRRLAGYAWRYPKDVVLALGASLGGMAVMALVPLITKVIIDDVVQDHTRSMAPWAGALIGAALVVYVFTYIRRYYGGRLALDVQHDLRNEMYGTITRLDGRRQDELSTGQVVGRATSDLQLIQGLLFMLPMTIGNVLLFLISLVIMAWLSLPLTLVALAVAPALWFIAKRSRSRLHPATWYAQAQAAAVAGVVDGAVSGVRVVKGFGQEDQETGKLREVGRRLFAGRLRTIRLNSKFTPALQAVPALGQVAMLALGGWLAVRGQITLGTFVAFSSYLAQLVGPVRMLAMVLTVGQQARAGVERVLELIDTEPSIEDGKKELPADAPATVEFDDVSFSYEGADRAVLDGLSFEIPAGQTLAVVGSSGSGKSTVSLLLPRFYDVTHGAVLVGGHDVRELTLDSLRAAIGLVPEDSFLFSDTIRANIAYGTPDASDEQIETAARAAQADRFIAELPDGYDTTVGEHGLTLSGGQRQRIALARAILTDPRLLVLDDATSAVDARVEHEIHEALRGVMAGRTTLLIAHRRSTLGLADRIAVLDGGRLAAIGTHEELEAGSALYRRLLTDPDELGGVSPGHVAPALPDEDTSVRDELDAEFDAERGITPTLWTGDREPKDTALSGMPATPELLAQVDALPAATDVPDIDEARAVTPEESYGLRRLLRGFGGPLLISLALVALDAGMGLLLPVLIRHGIDEGVSQLALGAVWAAAAFGLVTVLVQWCAQIGETRMTGRTGERVLYSLRLKIFSQLQRLGLDYYERELTGRIMTRMTTDVDALSTFLQTGLVTAFVSVVTFFGIMGALLVIDVQLALVVFATLPPLIVGTFFFRRSSVKAYELARERVSVVNADLQESVAGLRIVQAFRRERSGAARFAERSGAYRSARIRGQWLISVYFPFVQFLSSVAAAAVLMVGAGRVEAGTLTTGALVAYLLYIDLFFAPVQQLSQVFDGYQQATVSLGRIQELLQEPTSTKDADEPLDVLSLRGDIVFEDVDFAYGAADEQEAALSDVALRIPAGQTVAFVGETGAGKSTLVKLVARFYDPTAGRVTIDGTDLRDLDLTSYRHRLGVVPQEAYLFQGTVRDAIAYGRPDATDAQVEAASRAVGAHEMIATLEGGYLHEVAERGRNLSAGQRQLIALARAELVDPDILLLDEATAALDLATEAQVNQATDRIAGKRTTLVVAHRLTTAARADRVVVMADGRVAEDGTHTELLALGGQYAELWRTFAGEPEPEAEISSSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-09-29" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JVT6</accession>
    <name>A0A2M9JVT6_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5">Gas vesicle structural protein</fullName>
            <shortName evidence="4">GVP</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">gvpA</name>
        <name evidence="7" type="ORF">CG723_08370</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CB01635</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Gas vesicles are small, hollow, gas filled protein structures that are found in several microbial planktonic microorganisms. They allow the positioning of the organism at the favorable depth for growth. GvpA type proteins form the essential core of the structure.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Vacuole</location>
            <location evidence="4">Gas vesicle membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 4 5">Belongs to the gas vesicle protein type A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN11006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN11006">
        <property type="protein sequence ID" value="PJN11006"/>
        <property type="gene ID" value="CG723_08370"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033172">
        <property type="term" value="C:gas vesicle shell"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005773">
        <property type="term" value="C:vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012506">
        <property type="term" value="C:vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00576">
        <property type="entry name" value="Gas_vesicle_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000638">
        <property type="entry name" value="Gas-vesicle_GvpA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018493">
        <property type="entry name" value="Gas-vesicle_GvpA_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00741">
        <property type="entry name" value="Gas_vesicle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00234">
        <property type="entry name" value="GAS_VESICLE_A_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00669">
        <property type="entry name" value="GAS_VESICLE_A_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4 5" id="KW-0304">Gas vesicle</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4 5" id="KW-0926">Vacuole</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="95"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="98"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="131"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PJN11006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="154" mass="16882" checksum="D9FDC9EC93EF8F39" modified="2018-04-25" version="1">MPATTYSDEVVACPPRAGTLYDVLELILDRGMVIDVFVRVSLVGIEILKIDARIVVASVDTYLRFAEACNRLDLERDSGSTTVPELLSGSAAKSIGKRKVRKAAETVGDTVRKAVGGHDDDSDEQDDDEAEQQERPRKRRAPARGSSRRRPVEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JWC8</accession>
    <name>A0A2M9JWC8_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PRD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_09625</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN11196.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN11196">
        <property type="protein sequence ID" value="PJN11196"/>
        <property type="gene ID" value="CG723_09625"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011608">
        <property type="entry name" value="PRD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036634">
        <property type="entry name" value="PRD_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63520">
        <property type="entry name" value="SSF63520"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51372">
        <property type="entry name" value="PRD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PRD" evidence="1">
        <location>
            <begin position="20"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN11196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="127" mass="13762" checksum="67B51B2885A7E780" modified="2018-04-25" version="1">MTDDPLIEALTGAVADTAEPVRDEDRHALARLLPLIEERAAAERILLDEDRRLALAVHALGFVRRVRAGEHLDALDPAVADEITPGPLAAARELIDAYGTPLGDAARDTEVVLLALHFETARQLQES</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-05-25" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JWG3</accession>
    <name>A0A2M9JWG3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">LacI family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CG723_09780</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN11223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN11223">
        <property type="protein sequence ID" value="PJN11223"/>
        <property type="gene ID" value="CG723_09780"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01392">
        <property type="entry name" value="HTH_LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000843">
        <property type="entry name" value="HTH_LacI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046335">
        <property type="entry name" value="LacI/GalR-like_sensor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00356">
        <property type="entry name" value="LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13377">
        <property type="entry name" value="Peripla_BP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00354">
        <property type="entry name" value="HTH_LACI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50932">
        <property type="entry name" value="HTH_LACI_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH lacI-type" evidence="4">
        <location>
            <begin position="9"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PJN11223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="348" mass="37323" checksum="C0BACCB5D9BFE4D1" modified="2018-04-25" version="1">MRRTPARRPTIKDIALRSGVSESAVSFALNGRPGVSEATRDRVRRVADQLGWRPSAAARALSGEGAATVGLVLARPASTLGVESFFLQLVSGIQEVLARRRLGLLFQVVEDLSAECDAYRRWWAERRVDGVLVVDPRADDPRPPLLDELGLPAVVIGSLPPGDDGTGHPGISNLWADDARAMASIVSHLHGLGHRRIVHIAGLPELAHTRRRIQSLRTEAERRGLTDVRSITTDYSDTEGAEVTRRVLASDAPPTAIVYDNDVLAVAGLAVAAGRGIPVPDRLSIVAWDDSVLCRTAHPSLTALVRDTTAFGRRAAEELLALLDGGPALRVEDELPHLEQRGSTAAAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JWI0</accession>
    <name>A0A2M9JWI0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_09700</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN11209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN11209">
        <property type="protein sequence ID" value="PJN11209"/>
        <property type="gene ID" value="CG723_09700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="35"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="67"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="96"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="127"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="159"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="183"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="205"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN11209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="227" mass="23314" checksum="1008DD8679D040DD" modified="2018-04-25" version="1">MCWSATADLVAGTAIAAVGAVCVARTFRARRPRDLPLAALPLLLGAHQIVESVLWRSGGGTGPVTLAWAVIALPVLALWVPAGVVCAAPRRARGRLLIPLAAGAVTAAGLAYALAARTVTAEIRGHTVGYALGLPHAGLLVAGYLLATVGSLLLSADRGLVLLGVLVAAGAAVCIALWRWEFISTWCAFAAVCSVALLRWTGRSAGQPVRTRPPRDRQPSGPGTPEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JWQ2</accession>
    <name>A0A2M9JWQ2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_10295</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN11313.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN11313">
        <property type="protein sequence ID" value="PJN11313"/>
        <property type="gene ID" value="CG723_10295"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="42"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="68"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN11313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="115" mass="13012" checksum="F64DC8BA5FB438A4" modified="2018-04-25" version="1">MTGEPRAARRLPGHPTQWEIDEQTTLGAAYVRSLMRSQLRTGLTAFAVLALPVVTLPLFFGALRNTTVVWIVLGFGCYPVLVLIAWWYVRRAERNERDFARLVHGRAARERHGAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JWV6</accession>
    <name>A0A2M9JWV6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_10270</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN11308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN11308">
        <property type="protein sequence ID" value="PJN11308"/>
        <property type="gene ID" value="CG723_10270"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014961463" evidence="2">
        <location>
            <begin position="34"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="47"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="245"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="48"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="72"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="258"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="275"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="333"/>
            <end position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN11308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="394" mass="39964" checksum="312B18AFD79CAD4E" modified="2018-04-25" version="1">MRSPTRTLVTAFAISAALLVAGCSGDSGNNASADKGELFLQPVAEVGNDPFTDSTATTTETPAPVTRTPQPPSPSGTATATTQGMRPVDGATPGLYGGTQSVGSCDVEKQVAFLTSDPTKERAFADAAGISATSVPSFLRGLTPVVLRADTRVTNHGYRSGEATSYQSVLQAGTAVLVDARGMPRVRCACGNPLAPPVAFTGTPNTQGQEWSGYRPTQVVVVTPAPKVITNIVIVNITNNTWIERKVGDDGQHDKRVPPPPMPKPNPSDSSKSPPPSSTSPSSSSSSSSSPSESSNSASPPSSQPPSDESAPPSSDESAPASSDESAPASEPAGPPTSAPGDTDTPPDSPPSDGSSDLGPDTVPDSPDSPDSPDRPDGSGLIPDEPSAENVLDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JX79</accession>
    <name>A0A2M9JX79_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Cation/H(+) antiporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CG723_11400</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN11501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN11501">
        <property type="protein sequence ID" value="PJN11501"/>
        <property type="gene ID" value="CG723_11400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015299">
        <property type="term" value="F:solute:proton antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006812">
        <property type="term" value="P:cation transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006153">
        <property type="entry name" value="Cation/H_exchanger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038770">
        <property type="entry name" value="Na+/solute_symporter_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00999">
        <property type="entry name" value="Na_H_Exchanger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="32"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="56"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="115"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="149"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="177"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="217"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="291"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="323"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="356"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="domain" description="Na_H_Exchanger" evidence="6">
        <location>
            <begin position="13"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="395"/>
            <end position="430"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PJN11501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="430" mass="44035" checksum="B0F578BAC0957840" modified="2018-04-25" version="1">MHSAVFLIEFGAIILALGLLGRFAGRFRFSPIPLYLLAGLAFGEGGLLPLGASEEFVAIGAEIGVILLLLMLGLEYTASDLVSNLKTQYPAGLVDCAFNALPGAAAALLMGWGPVAAVVLAGVTWISSSGVIAKVLGDLGRVGNRETPVILSILVLEDLAMAVYLPIITALLAGVGWAAGGVTLAIALGAAGLVLFLAVRYGRLISRFVSSDDPEKLLLVVLGLTILVAGIAQQLQVSAAVGAFLVGIALSGEVAEGAHSLLLPLRDLFAAVFFVFFGLHTDPASIPPVLLPALALAVVTACTKIATGYWAARRAKISVKGRWRAGGALVARGEFSIVIAGLAVTAGIEPRLGPLATAYVLILVIVGPLTARFTEPVAARVSRWRQRGDAPAAAVTAGASIVPAQRDPQDPVGPEAEAHGTSGRASNSSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JXM8</accession>
    <name>A0A2M9JXM8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">HAD family hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CG723_12175</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN11633.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN11633">
        <property type="protein sequence ID" value="PJN11633"/>
        <property type="gene ID" value="CG723_12175"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006439">
        <property type="entry name" value="HAD-SF_hydro_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041492">
        <property type="entry name" value="HAD_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023198">
        <property type="entry name" value="PGP-like_dom2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13419">
        <property type="entry name" value="HAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00413">
        <property type="entry name" value="HADHALOGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01549">
        <property type="entry name" value="HAD-SF-IA-v1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01509">
        <property type="entry name" value="HAD-SF-IA-v3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PJN11633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="220" mass="23634" checksum="0D51A3A11E83C3F4" modified="2018-04-25" version="1">MRPGGCLLGTRISAVLFDFGGVLTSSVFKAFEAFGTKLGVDPRLPLRLLAKDEPSGALLVEHEEGRLGQRDFEDGFAERLRAHGADVQGPGLLSLMQTELRPDRAMLDLVAELRTAGHRVGLLSNSLGDDCYAGFDLESMFDAVAISGEIGVRKPSRRAYAIACERLGTEPAETVMVDDLEHNIVAARRAGLAGIVHREAAATAKELRSLLHLDVAKEAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JY43</accession>
    <name>A0A2M9JY43_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Peptidase C26</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CG723_13160</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN11793.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN11793">
        <property type="protein sequence ID" value="PJN11793"/>
        <property type="gene ID" value="CG723_13160"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016811">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011697">
        <property type="entry name" value="Peptidase_C26"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044668">
        <property type="entry name" value="PuuD-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43235">
        <property type="entry name" value="PTHR43235"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07722">
        <property type="entry name" value="Peptidase_C26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PJN11793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="241" mass="25478" checksum="FAA6002B51F27F98" modified="2018-04-25" version="1">MTTRPLIAVPARFAASTSALRYAAEVNARALIEAVWNAGGEPVTLHPHAPGGTADPGEVAARLARFDGLLLPGGGDIAPHRYGVAAAHASVYDVDDTQDAFDLELARQALDAAIPLLAICRGLQVVNTALGGTLHQDMGGPEREHRHLVHPVAIERLSLLEQATGTEKVDASCYHHQRVDRLGSGLSVTARAGDGTVEALELPEARGWFTAVQWHPEDTAHEDGAQQGIFDALVRAARAHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JY64</accession>
    <name>A0A2M9JY64_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">GntR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CG723_13285</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN11812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN11812">
        <property type="protein sequence ID" value="PJN11812"/>
        <property type="gene ID" value="CG723_13285"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07377">
        <property type="entry name" value="WHTH_GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.530">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011711">
        <property type="entry name" value="GntR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008920">
        <property type="entry name" value="TF_FadR/GntR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07729">
        <property type="entry name" value="FCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
        <property type="entry name" value="GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00035">
        <property type="entry name" value="HTHGNTR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00895">
        <property type="entry name" value="FCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00345">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48008">
        <property type="entry name" value="SSF48008"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50949">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH gntR-type" evidence="4">
        <location>
            <begin position="8"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PJN11812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="212" mass="23663" checksum="86B48D78DCB08FA1" modified="2018-04-25" version="1">MAGSGEFEPESERVTRQLRDDILDGVRKPGSKLVERELAAQIGVSRVPVRDALRVLVAEGLVTPRPRTWAVVREFTPTDIADLNEVREALEVMTFRLAAQRRDRAGLEQLRTKLDEELTAARAGDAVRARRAAADFHETVTSMAANELLSELEVTLRSRMRWLLGQHDDLLAMALEHEALYGAIEDRDVSLVEELVVEHLASSRRAIANGPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JYK1</accession>
    <name>A0A2M9JYK1_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ferritin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_14130</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN11950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN11950">
        <property type="protein sequence ID" value="PJN11950"/>
        <property type="gene ID" value="CG723_14130"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012347">
        <property type="entry name" value="Ferritin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026820">
        <property type="entry name" value="VioB/RebD_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12902">
        <property type="entry name" value="Ferritin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ferritin-like" evidence="1">
        <location>
            <begin position="43"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN11950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="275" mass="30197" checksum="F2365F986900EE1E" modified="2018-04-25" version="1">MRPKERMNETVSIPPRTVEAGDDHVFPPATTTVHTRAELDLLLRSALALEHATIPPYLCAMFSLKDGKNREVERIIRSVVMQEMLHLALIGNIMNSIGTTPRFDDPDLVPVYPGRLPGGVMPDLEVSLGACSIERVRQVFMGIELPEEPLAPAGQRALQAISGYNPLLDEHGNIQNLNEEALDAPRKFFALADYDATTVGGFYQHIAQALTDLDASDENLFGGDPRRQVSWPHAPGRLYRVTNLQTALWAILEIIDQGEGHAQDPTVGPLPGRAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-05-25" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JYR3</accession>
    <name>A0A2M9JYR3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_14495</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN12014.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN12014">
        <property type="protein sequence ID" value="PJN12014"/>
        <property type="gene ID" value="CG723_14495"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097367">
        <property type="term" value="F:carbohydrate derivative binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901135">
        <property type="term" value="P:carbohydrate derivative metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05013">
        <property type="entry name" value="SIS_RpiR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000281">
        <property type="entry name" value="HTH_RpiR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035472">
        <property type="entry name" value="RpiR-like_SIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001347">
        <property type="entry name" value="SIS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046348">
        <property type="entry name" value="SIS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01418">
        <property type="entry name" value="HTH_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01380">
        <property type="entry name" value="SIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53697">
        <property type="entry name" value="SSF53697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51071">
        <property type="entry name" value="HTH_RPIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51464">
        <property type="entry name" value="SIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH rpiR-type" evidence="1">
        <location>
            <begin position="11"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="domain" description="SIS" evidence="2">
        <location>
            <begin position="136"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN12014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="296" mass="31808" checksum="1EDC547D22EEB7E8" modified="2018-04-25" version="1">MEISEDGTGATRLRAAIRDQWDELSTSERAVAQHLASAPVEQLLFASAQELGTASSTSNATVVRALQRLGYAGLPALKRELASDFTSAVAPEVRLKQRIAHVGRDLASIWTDVFDEARERIDHTQRLTEPDALKRAVAALAEAHEVFCYGIAASEPGARHLALALGRIGHRARFVSETGFALADQLLALGQGDAVVIFQPGRQLVELTVMMDRARAVGAKVVLVTDELGEAYEDQVEAVLTAPHTPTGITAESLTGLLVADALLLALATLDESRAVDSSHQLTALREQLLRPKRRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JZ94</accession>
    <name>A0A2M9JZ94_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">GntR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_12710</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">In the C-terminal section; belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN12191.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN12191">
        <property type="protein sequence ID" value="PJN12191"/>
        <property type="gene ID" value="CG723_12710"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044249">
        <property type="term" value="P:cellular biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="CDD" id="cd07377">
        <property type="entry name" value="WHTH_GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
        <property type="entry name" value="GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00345">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50949">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH gntR-type" evidence="2">
        <location>
            <begin position="9"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN12191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="468" mass="50390" checksum="9E8D3DCA6670FF94" modified="2018-04-25" version="1">MLPDTAGTRPAYRHLAQAISTLILDGRIALHVRLPAERELAAALDTSRTTVTAVYDLLRESGYAHSRQGSGTWTALPEGRTPSGITRLLGPQDTAIDLARASPGLPQQALVDALVHITPQLAEQAHTPGYHPYGLPDLRAAVAERYTRRGLATLPEQILVTSGAQHALTLVLGLLSSPGDRVMVENPSYPNALEALRRARLRTVTVPVTDTGWDIEITESTLRQVVPQLAYLIPDFHNPTGCLMPEHERVCVLRAAERSGTWLVIDETLADLALDVPPPPPFASHAAKGGTGQVISIGSMSKTHWGGLRIGWLRAPARLVTELAGQRVATDMGGSVVDQLLALALLDRADGLLPLRLEQLRVQRAALAAALTQHMPHWTWQLPPGGLSLWVDLGEPVASALSERALDNGVRIESGACFATDPGIFEQRMRIPYTTPADTLREAVHRMATALAAGLPSASTARRPHWVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JZH3</accession>
    <name>A0A2M9JZH3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Divalent-cation tolerance protein CutA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_04170</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CutA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000002">
        <property type="protein sequence ID" value="PJN12266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN12266">
        <property type="protein sequence ID" value="PJN12266"/>
        <property type="gene ID" value="CG723_04170"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010038">
        <property type="term" value="P:response to metal ion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004323">
        <property type="entry name" value="Ion_tolerance_CutA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011322">
        <property type="entry name" value="N-reg_PII-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015867">
        <property type="entry name" value="N-reg_PII/ATP_PRibTrfase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23419">
        <property type="entry name" value="PTHR23419"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03091">
        <property type="entry name" value="CutA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54913">
        <property type="entry name" value="SSF54913"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN12266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="108" mass="11412" checksum="C9366AB02592AC7E" modified="2018-04-25" version="1">MNALALTVLTATDDEAKARALATGAVEARLAACAQIAGPVMSVYRWQGSTETAQEWQVLLKTTAEGYEALESWLLEAHDYETPEIIATPVVRGSAGYLAWIAGETGGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JZN4</accession>
    <name>A0A2M9JZN4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Chemical-damaging agent resistance protein C</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_04615</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000002">
        <property type="protein sequence ID" value="PJN12341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN12341">
        <property type="protein sequence ID" value="PJN12341"/>
        <property type="gene ID" value="CG723_04615"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06974">
        <property type="entry name" value="TerD_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003325">
        <property type="entry name" value="TerD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02342">
        <property type="entry name" value="TerD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TerD" evidence="1">
        <location>
            <begin position="1"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN12341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="191" mass="20247" checksum="114F9694B2D92A06" modified="2018-04-25" version="1">MGVSLSKGGNVSLTKEAPGLTAVIIGLGWDVRTTTGTDFDLDASAILTNTEGKVSSDANFVFFNNLKSPDGSVEHTGDNTTGEGEGDDEQLKVNLAGVPADVDKIVFPVSIYDAENRQQSFGQVRNAFIRVVNQAGGAEIARYDLSEDASTETAMVFGELYRNGAEWKFRAIGQGYASGLRGIAQDFGVNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JZV0</accession>
    <name>A0A2M9JZV0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CG723_05025</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000002">
        <property type="protein sequence ID" value="PJN12409.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN12409">
        <property type="protein sequence ID" value="PJN12409"/>
        <property type="gene ID" value="CG723_05025"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PJN12409.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="216" mass="23003" checksum="B643E36AC02928B5" modified="2018-04-25" version="1">MSAAPKPEILVAFEAAKGFMPLGEGLALYAAATEAAALGLPLLEVGTYCGRSTILLADAARQAGVSALTVDHHRGSEEQQPGWDYHDPETVDPVVGRMDTLPTFRRTLHAAGLEDHVVALVGRSPQVAAVWGGKLGLVFIDGGHTDEHATADYEGWAPHVAEGGLLLIHDVFPVKIDEWTGQAPYRIYLRALESGAFTEVSATESLRVLRRTGTGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JZZ4</accession>
    <name>A0A2M9JZZ4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_05335</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000002">
        <property type="protein sequence ID" value="PJN12462.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN12462">
        <property type="protein sequence ID" value="PJN12462"/>
        <property type="gene ID" value="CG723_05335"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014909417" evidence="2">
        <location>
            <begin position="20"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="28"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN12462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="65" mass="6822" checksum="6D8FB19A735EC259" modified="2018-04-25" version="1">MPRLALYALVVCVLSTAAAVVAFVQGSLLGIVWVLLAGLTSNMAWYYARRAKAEKQANAAVAPTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K018</accession>
    <name>A0A2M9K018_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">TolB-like translocation protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_05455</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000002">
        <property type="protein sequence ID" value="PJN12482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN12482">
        <property type="protein sequence ID" value="PJN12482"/>
        <property type="gene ID" value="CG723_05455"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011659">
        <property type="entry name" value="PD40"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07676">
        <property type="entry name" value="PD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014780118" evidence="2">
        <location>
            <begin position="29"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="34"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN12482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="343" mass="37344" checksum="DCAB39F8EC0A949C" modified="2018-04-25" version="1">MTTRNRLLVLVAAVVALAAVATASILQAAARADRRNEAHAGGPRVTAGRVTLPTEATEAPRRLVFRNMAWGPHRDELTTVPAGRPDAPRTASGVKCLRFYASSGTAICLRAERGAMQDTYTARVLDSRLEEKARYALPGIPSRARVSPSGRYAAWTVFVGGDSYAGTNFSTRAAIVDTRTGHLTPTLEDFRVVKDGRTYRAADINFWGITFAADDRHFYATLATHGKTYLVRGDLRTRTLTTVHQNVECPSLSPDGTRIAYKKRVKGLSADAPWRLYVLDLRTLRETPLAETRSVDDQAVWSDAHTLTYALPGDYGADLYTVPADGTGAPHRLTKAAVSPAYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K090</accession>
    <name>A0A2M9K090_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">F5/8 type C domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CG723_05685</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CB01635</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Alpha-L-fucosidase is responsible for hydrolyzing the alpha-1,6-linked fucose joined to the reducing-end N-acetylglucosamine of the carbohydrate moieties of glycoproteins.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000002">
        <property type="protein sequence ID" value="PJN12524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN12524">
        <property type="protein sequence ID" value="PJN12524"/>
        <property type="gene ID" value="CG723_05685"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004560">
        <property type="term" value="F:alpha-L-fucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042806">
        <property type="term" value="F:fucose binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006004">
        <property type="term" value="P:fucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010185">
        <property type="term" value="P:regulation of cellular defense response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001868">
        <property type="term" value="P:regulation of complement activation, lectin pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018905">
        <property type="entry name" value="A-galactase_NEW3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000421">
        <property type="entry name" value="FA58C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006585">
        <property type="entry name" value="FTP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016286">
        <property type="entry name" value="FUC_metazoa-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031919">
        <property type="entry name" value="Fucosidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000933">
        <property type="entry name" value="Glyco_hydro_29"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10030">
        <property type="entry name" value="PTHR10030"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01120">
        <property type="entry name" value="Alpha_L_fucos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00754">
        <property type="entry name" value="F5_F8_type_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16757">
        <property type="entry name" value="Fucosidase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10633">
        <property type="entry name" value="NPCBM_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00741">
        <property type="entry name" value="GLHYDRLASE29"/>
    </dbReference>
    <dbReference type="SMART" id="SM00812">
        <property type="entry name" value="Alpha_L_fucos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00607">
        <property type="entry name" value="FTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="SSF49785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50022">
        <property type="entry name" value="FA58C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014598680" description="F5/8 type C domain-containing protein" evidence="6">
        <location>
            <begin position="41"/>
            <end position="752"/>
        </location>
    </feature>
    <feature type="domain" description="F5/8 type C" evidence="7">
        <location>
            <begin position="588"/>
            <end position="749"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="508"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="516"/>
            <end position="532"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PJN12524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="752" mass="81783" checksum="9B350EA98C2ED8A2" modified="2018-04-25" version="1">MTHLRPRPARNARRRACAAVLTAACAALLGLPATGGPAAAQDAPPAKDYEPTLDSLNSHPTPSWFDDDKFGIFIHWGAYSVPAWGPRGSYAEWYWAYMNDAGSPTNQHHKDTYGTAANYDDFIGQWKAEKYDPDAWVKLFKDAGAKYFVLTSKHHEGVALWDSKVSGRDTVDLGPHRDLAGDLFKAARKEKGLKAGFYYSLYEWNNPSYTGRPVTNPYTGAPVPYTGAPAVKDYVADYMAPQMRELIDQYDPDLLWCDGQWEKPASYWKTAPVLADYYNRAKNRKHPKEVAVANRCKIDTGALDSTELDFQTPEYTVKSEIDPNKWEASRGIAHSYGYNQNEPEEDYLTSDQLVDSLSDIVSKNGNLLLDVGPRGDGTIPELQQQRLMDIGAWLKTNGEAVYGTTYWHHAEEPSSDDTVRYTVKDGALYATALKWPGEQLTLGADTPVRKGTRISLLGSDAGPLTWHKDDRGRVVVDTPAETGKYAYVFKIETPGVHSLARTRTELPKELNPGRTADGTLTVTNTSRKKAPGTQVTIGAPDGWTVTPKAAGVPPQGPGASTEVPFEVTPPRSAKPGSYELPITLRHAGMTVTTTVKATVAAENLALGKSATQKSTAWDAPASRAVDGNTDGTFGAGSVSHTAEPSNQAWWQVDLGAKADLSSVDIWNRTDCCAERLSDFWVLTSDSPITADSLDEARKSPGVTAVRVADQAGKPSNVALPSGTTGRYVRVQLESAADPLSLAEVQVRGSAQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K0C2</accession>
    <name>A0A2M9K0C2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GNAT family N-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_05720</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000002">
        <property type="protein sequence ID" value="PJN12530.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN12530">
        <property type="protein sequence ID" value="PJN12530"/>
        <property type="gene ID" value="CG723_05720"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="4"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN12530.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="162" mass="17747" checksum="A5504D0A6F749F16" modified="2018-04-25" version="1">MPQPHIRLARLDDEDGLARLDRAAWSTLHAVQPEPLPPYDPFFSERFGPRDHLVAECDGRLAGYVRIAYPTSLAANTHVRQIQGLAVAAEARGTGVGRALVRAAVEHARKAGARRMTLRVLGHNAPARALYESEGFTVEGVLPEEFLLDGKYVDDILMGQAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K0I5</accession>
    <name>A0A2M9K0I5_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA polymerase III subunit alpha</fullName>
            <ecNumber evidence="2">2.7.7.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CG723_06350</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CB01635</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1)</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.7" evidence="2"/>
    <dbReference type="EMBL" id="NNBL01000002">
        <property type="protein sequence ID" value="PJN12643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN12643">
        <property type="protein sequence ID" value="PJN12643"/>
        <property type="gene ID" value="CG723_06350"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008408">
        <property type="term" value="F:3'-5' exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1600">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011708">
        <property type="entry name" value="DNA_pol3_alpha_NTPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041931">
        <property type="entry name" value="DNA_pol3_alpha_thumb_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040982">
        <property type="entry name" value="DNA_pol3_finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029460">
        <property type="entry name" value="DNAPol_HHH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004365">
        <property type="entry name" value="NA-bd_OB_tRNA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004013">
        <property type="entry name" value="PHP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003141">
        <property type="entry name" value="Pol/His_phosphatase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016195">
        <property type="entry name" value="Pol/histidinol_Pase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004805">
        <property type="entry name" value="PolC_alpha"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32294">
        <property type="entry name" value="PTHR32294"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07733">
        <property type="entry name" value="DNA_pol3_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17657">
        <property type="entry name" value="DNA_pol3_finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14579">
        <property type="entry name" value="HHH_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02811">
        <property type="entry name" value="PHP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01336">
        <property type="entry name" value="tRNA_anti-codon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00481">
        <property type="entry name" value="POLIIIAc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89550">
        <property type="entry name" value="SSF89550"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00594">
        <property type="entry name" value="polc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0235">DNA replication</keyword>
    <keyword evidence="7" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="5" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="POLIIIAc" evidence="10">
        <location>
            <begin position="7"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="78"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00024632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PJN12643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="1179" mass="130799" checksum="86064B60670BC690" modified="2018-04-25" version="1">MSKPPFTHLHVHTQYSLLDGAARLKDMFNACNEMGMTHIAMSDHGNLHGAYDFFHTAKKSGVVPIIGIEAYVAPESRRNKRKVQWGQPHQKRDDVSGSGGYTHKTIWAANSTGLHNLFKLSSDAYAEGWLTKWPRMDKETISQWSEGLIASTGCPSGELQTRLRLGQFDEAVKAAAEYQDIFGKDRYFLELMDHGIDIERRVRDDLLRVGKKLGIPPLVTNDSHYTYAHEATAHDALLCIQTGKNLSDPDRFRFDGTGYYLKTTDEMYAIDSSDAWQEGCANTLLVAEQIDTTGMFEKRDLMPKFEIPDGFTEVTWFQEEVRVGMDRRYPGGVPEDRQKQAEYEMDIIIQMGFPGYFLVVADFIMWAKNNGIAVGPGRGSAAGSIVAYAMGITDLDPITHGLIFERFLNPERVSMPDVDIDFDERRRVEVIRYVTEKYGADKVAMIGTYGKIKAKNAIKDSARVLGYPYAMGDRLTKAMPADVLGKGIDLSGITDPAHPRYSEAGEIRGMYENEPDVKKVIDTAKGVEGLVRQMGVHAAGVIMSSEPIVDHAPLWTRHTDGVTITQWDYPQCESLGLLKMDFLGLRNLTIMDDAVKMVRANKGVDLEMLALPLDDPKTYEMLCRGDTLGVFQFDGGPMRSLLRQMQPDNFEDISAVSALYRPGPMGMNSHTNYAERKNGRQEITPIHPELEEPLKETLGLTYGLIVYQEQVQKAAQIIAGYSLGEADILRRVMGKKKPEELEKNFVLFQAGAKKKGFSDAAIQALWDVLVPFAGYAFNKAHSSAYGLVTYWTAYLKANYPAEYMAALLTSVKDDKDKSAVYLNECRRMGIKVLPPNVNESEHNFAAQGDDVILFGLSAVRNVGTNVVESIIRSRKAKGKYASFPDYLDKVEAAACNKRTTESLIKAGAFDTMGHTRKGLTAQYEPMIDNVVQVKRKEAEGQFDLFGGMGEEDSSEPGFGLDVEFSEDEWEKTYLLAQEREMLGLYVSDHPLFGLEHVLSDKADAGIGQLTGGDYSDGSIVTIGGIISGLQRKMTKQGNAWAIATVEDLAGSIECMFFPATYQLVSTQLVEDAVVFVKGRLDKREDVPRLVAMELMVPDLSNAGTNAPVTITIPTVKVTPPMVSRLGEILSHHKGNSEVRIKLQGARKTTVLRLDRHRVQPDPALFGDLKVLLGPSCLAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K0J5</accession>
    <name>A0A2M9K0J5_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Cell wall synthesis protein Wag31</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Antigen 84</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CG723_06275</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CB01635</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DivIVA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000002">
        <property type="protein sequence ID" value="PJN12634.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN12634">
        <property type="protein sequence ID" value="PJN12634"/>
        <property type="gene ID" value="CG723_06275"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007049">
        <property type="term" value="P:cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019933">
        <property type="entry name" value="DivIVA_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007793">
        <property type="entry name" value="DivIVA_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35794">
        <property type="entry name" value="PTHR35794"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05103">
        <property type="entry name" value="DivIVA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03544">
        <property type="entry name" value="DivI1A_domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="5 11" id="KW-0132">Cell division</keyword>
    <keyword evidence="6 9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="54"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="297"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="232"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="149"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="335"/>
            <end position="365"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PJN12634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="396" mass="41309" checksum="BD6ACB188E5C5159" modified="2018-04-25" version="1">MPLTPEDVRNKQFTTVRLREGYDEDEVDAFLDEVEGELTRLLRENEDLRAKLAAATRAAAQNQQQGGMRKPPEPQDQRGPGAPVPAAISGPQPVQPQQQMGGPMGGPPQLPSGAPQLPAGPGGHGPQGPGQQGPGPMGQGPMGQGHPGQGHPGQNQLGQGQMGQGQLQQQMGGPMGGPMGGPMGGHGPQMPQPGQGPGGDSAARVLSLAQQTADQAIAEARSEANKIVGEARSRAEGLERDARAKADALERDAQEKHRVAMGSLESARATLERKVEDLRGFEREYRTRLKSYLESQLRQLETQADDSLAPPRTPATASLPPSPAPSMASAGAGAPSYGGNQTMGGNQPPAGPSYGGQQQMSPAMTQPMAPVRPQGPAPMQQAPSPMRGFLIDEDDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K0M3</accession>
    <name>A0A2M9K0M3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Monooxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_06590</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000002">
        <property type="protein sequence ID" value="PJN12685.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN12685">
        <property type="protein sequence ID" value="PJN12685"/>
        <property type="gene ID" value="CG723_06590"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016646">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002563">
        <property type="entry name" value="Flavin_Rdtase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01613">
        <property type="entry name" value="Flavin_Reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00903">
        <property type="entry name" value="Flavin_Reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flavin_Reduct" evidence="1">
        <location>
            <begin position="18"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN12685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="183" mass="19097" checksum="57517194CF7334A6" modified="2018-04-25" version="1">MPIPTHHATSAEDLKSALAGFCTGVAVITALDGDGRPAGMAVQSFSSVSLDPPLVCFCPAHTSTTWPRIRAAGRFAVNVLAEDQRELCRRFAVTGGDKFAGTPWRPGGNGAPLLDGALATIECELADVLDGGDHAIALGRVTSLTAHRDAGPLLYFRRAYGRLPRSSSSMSASMASARSRSDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K0P4</accession>
    <name>A0A2M9K0P4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">IclR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CG723_06720</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000002">
        <property type="protein sequence ID" value="PJN12705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN12705">
        <property type="protein sequence ID" value="PJN12705"/>
        <property type="gene ID" value="CG723_06720"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014757">
        <property type="entry name" value="Tscrpt_reg_IclR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005471">
        <property type="entry name" value="Tscrpt_reg_IclR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09339">
        <property type="entry name" value="HTH_IclR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01614">
        <property type="entry name" value="IclR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00346">
        <property type="entry name" value="HTH_ICLR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51077">
        <property type="entry name" value="HTH_ICLR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51078">
        <property type="entry name" value="ICLR_ED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH iclR-type" evidence="3">
        <location>
            <begin position="13"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="domain" description="IclR-ED" evidence="4">
        <location>
            <begin position="74"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PJN12705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="289" mass="30934" checksum="EB50AAB1153A07B0" modified="2018-04-25" version="1">MPEQTGFVEGSAPSLLEKAAKVLGAFDGAQPRLSLTEVIRRSGIPRSSAHRILDQLVRLGWLDREGRDYRMGMGMLELGALAAHHNRLRRTALPRLHALHESAGHLVHLYVLDGAEVVCLERIGGLHDTSVPSRVGGRMPAYCTAAGKAVLAFSDPAAVEGVLAHGLRPRTPRTLTHPTALRSALAAARDRGVAFDHEESHRDVVCVAAPLRGAGRAVAAISLSGKGLTAQRDLERLAPAVLACARAVWRDLYGPGRATRAAPPPSCAPGVSEQAMDNMMGWLRTSEWM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K183</accession>
    <name>A0A2M9K183_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CG723_07745</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CB01635</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 25 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000002">
        <property type="protein sequence ID" value="PJN12892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN12892">
        <property type="protein sequence ID" value="PJN12892"/>
        <property type="gene ID" value="CG723_07745"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003796">
        <property type="term" value="F:lysozyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016998">
        <property type="term" value="P:cell wall macromolecule catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009253">
        <property type="term" value="P:peptidoglycan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002053">
        <property type="entry name" value="Glyco_hydro_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018077">
        <property type="entry name" value="Glyco_hydro_fam25_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01183">
        <property type="entry name" value="Glyco_hydro_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00641">
        <property type="entry name" value="Glyco_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51904">
        <property type="entry name" value="GLYCOSYL_HYDROL_F25_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014728359" evidence="4">
        <location>
            <begin position="38"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PJN12892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="247" mass="27372" checksum="7B87BE72F2BB91B5" modified="2018-04-25" version="1">MARGHKPSRRRAQIAAATSLAALTFGGTALAQAPASAAGGTKGHDVSSHQTNVDWQKAKSKGARFVYVKATESTTYRNPYFSRQYNGARSAGIIRGAYHFALPNKSSGRTQASYFVRNGGGWRADGWTLPPALDIEYNPYSSKKCYGLSKGKMISWIRSFSDEVRRRTGRRPVIYTNYRWWKNCTGNSAAFAGNHALWLARYDESAGALPSGWSYWTFWQYDNSGGLPGDQNLFNGSQAQLRRFARG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K1T7</accession>
    <name>A0A2M9K1T7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_00360</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000001">
        <property type="protein sequence ID" value="PJN13094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN13094">
        <property type="protein sequence ID" value="PJN13094"/>
        <property type="gene ID" value="CG723_00360"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="171"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN13094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="213" mass="23124" checksum="ACD8D184C09A8B41" modified="2018-04-25" version="1">MTFGFAPSSATSLSTSSTRADMSADSANQLARVLEPAEWAAAGIPLLRNPREVVSGLHARHRPKPQTAVVAVLDTEERLSASASFTRRASAADGWVFRNALLTHLRRVIPHDLRRRTPVRTAVLLYCREGDARWTEEDGAWMWGLRDACTLHGLRCGAYITMTRDGWQVLGEGRGGRRPSLGSTPEAFEGGVEPPLPRAGGAASEVLRRAAAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-09-29" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K272</accession>
    <name>A0A2M9K272_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">NlpC/P60 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_01165</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C40 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000001">
        <property type="protein sequence ID" value="PJN13229.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN13229">
        <property type="protein sequence ID" value="PJN13229"/>
        <property type="gene ID" value="CG723_01165"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000064">
        <property type="entry name" value="NLP_P60_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00877">
        <property type="entry name" value="NLPC_P60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="SSF54001"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51935">
        <property type="entry name" value="NLPC_P60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NlpC/P60" evidence="2">
        <location>
            <begin position="186"/>
            <end position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN13229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="356" mass="39342" checksum="3F15090EC37D8C13" modified="2018-04-25" version="1">MSAKKKHPVLHTAIVLSLLGGSAYLTVELRKDEQAKAPAVQAVTDTPLLESSTGQQGGERNWERLKNPERSVLRGEGGQVLATFTDSARTATLKGPSRTFTEPANTKSRVVTEDWVRLMPEPWRKGAEKEKWFKDWFKEFYGSEEDDIFAFAFQYLEGAPVKKDDEGIAYGGDANFGPINPNGSEGNDLRDELSDFYDYLGIPYTFRDGVTQQPETKRARSVDCSGFQRLVWGYRARYPLMSSDKSGDGLPRTANGMARSDVGADIIPLKGVGAADRPQSIDVLQPGDLVFFKLDARTNQRLDHVGLYMGHDTDGHMIFVSSREEVNGPTIGDKGGTSRLDGNGYYASTLRSAKRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K2A3</accession>
    <name>A0A2M9K2A3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CG723_01065</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CB01635</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000001">
        <property type="protein sequence ID" value="PJN13210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN13210">
        <property type="protein sequence ID" value="PJN13210"/>
        <property type="gene ID" value="CG723_01065"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="7"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="71"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="115"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="165"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="228"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="275"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="67"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PJN13210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="307" mass="34068" checksum="478D8FAC77CFF64B" modified="2018-04-25" version="1">MQHGKYRFIAGFLVTPLALYAVFVIWPFIQSIYYSFTDWTGLSPDFKMVGFANYKRMFEDDVFWKSLQHSVLLALLLPLVTLGLALFFAFMLNVGGRRRKGVAITGVRGSGFYKIAYFFPQVLSIAIVAILFRFAFNPNDGVINGTLKAVGLGSIQPDWLGDPNFALWCVMSVLVWSTVGFFVVLFSAGMASIPKDFYEAALLDGASRFTTFFRITLPLLWDTVQSGWVYMGILALGAEAFASVQIMTVGPGGPDYSTTVLPLYVYQSAFRDANAAYATTIGVALLIVTLLFAAVVMRLGRRERLEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K2A7</accession>
    <name>A0A2M9K2A7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_01355</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000001">
        <property type="protein sequence ID" value="PJN13262.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN13262">
        <property type="protein sequence ID" value="PJN13262"/>
        <property type="gene ID" value="CG723_01355"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045392">
        <property type="entry name" value="DUF6519"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20129">
        <property type="entry name" value="DUF6519"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="96"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="487"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="488"/>
            <end position="502"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN13262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="522" mass="56871" checksum="B7EFD47B2B3FC021" modified="2018-04-25" version="1">MHADLSRLTFHPERHYSAVVAQQGRVQLDADANEQTAIQLHQARTLAADLIGRYGGPRDAAGFRIEYVGGKHDIDTLYIHGGRYYVDGILLDADRPAPGTPVPDEDAENAMDTEGAEDTAAPPSYWTYWDQPDAYRDAEKPGDRLPSPAQSPFVVYLNVWERSVNAAEDPALREVALGAAMPDTAARVKVVWQVLPLSLAALAIEDADPSKEVVRAAFDKWAQSQAATTARLAARSERPDHADEDPCLVRPDARYRGPENQLYRVEVHAGGEAKDATFKWSRENGSVVFPVDELDGTWVQLASLGHDDKLDLDVGDFVEFTDTACASRLEALPLLRVEELDLPGRRVRLSAEPGPGVGRLPHLHPFLRRWDHREGPKRRGRTAALKGGAVPVTEGEWLPLEDGVEVYFAKGGTYRTGDHWLVPARTATGSVEWPTDPARRPLLQGPAGVARHFAPLALVKGEESAVDLRLAFGPLAIGIPAADEATLAAEEQAHREELAAEGPSHSRSQTTAEAESAVEGDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K2S8</accession>
    <name>A0A2M9K2S8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_01975</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000001">
        <property type="protein sequence ID" value="PJN13370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN13370">
        <property type="protein sequence ID" value="PJN13370"/>
        <property type="gene ID" value="CG723_01975"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="400"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="460"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="109"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN13370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="487" mass="51615" checksum="35A840A8C09206A5" modified="2018-04-25" version="1">MARLRGSRRPRWRPAPGATVDAARLREEITGHEGGTGGPLRFEGLRVRGRLDLSRCRVDTVLELVDCVFDEPLRLAELAVGALNLSGSEAPALHANRITVDGDLRLSGATLGSGTPVPQPLTAPPAAGDGPRVPRRLPEDSTSAVLELADARIDGNLVVEELTVADSGPWSLLAPRLNVAGSVHARGLTASGALYLRDAQIAYALNLNGADVGGLDGTGLACGRGLYADWGFRSAGQVLLRAAVIEGVVTFHDSVIGAPAGALLLSRLRVPRLRLDLREPPTDAVVLQDAAVDVLVDSAATWAAPGRLNLEGFTYKRLESAGPVDVRARIGWLTRDPNAGAGSFEQLATSYESAGDERSARTVRHARERHVRRLDRLSGRAWGLVQDLLFGYGYAPRRALVWLLSLAAAGSLWFAFHEPRAVGGSGQRAWDPVLYSVDLLIPVASLGYRGSWDPQGAGKAVAVFLVVSGWTLATAVLAGARRVIGRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K2S9</accession>
    <name>A0A2M9K2S9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">IclR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CG723_02320</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000001">
        <property type="protein sequence ID" value="PJN13429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN13429">
        <property type="protein sequence ID" value="PJN13429"/>
        <property type="gene ID" value="CG723_02320"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014757">
        <property type="entry name" value="Tscrpt_reg_IclR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005471">
        <property type="entry name" value="Tscrpt_reg_IclR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09339">
        <property type="entry name" value="HTH_IclR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01614">
        <property type="entry name" value="IclR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00346">
        <property type="entry name" value="HTH_ICLR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51077">
        <property type="entry name" value="HTH_ICLR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51078">
        <property type="entry name" value="ICLR_ED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH iclR-type" evidence="3">
        <location>
            <begin position="20"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="domain" description="IclR-ED" evidence="4">
        <location>
            <begin position="82"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PJN13429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="266" mass="27840" checksum="55133933F9AFDE78" modified="2018-04-25" version="1">MPTSSASTKSSGPSAPTGGVQSLERAFDLLERMADAGGEVGLSELSASSGLPLPTIHRLMRTLVACGYVRQQTNRRYSLGPRLIRLGESASRLLGTWARPYLARLVEVTGETANMALLDGDEIVYVAQVPSKHSMRMFTEVGRRVLPHSTGVGKALLADTPADEVRALLARTGMPAATEKTITTADGFLDALAEVRRAGYAVDDNEQEIGVRCLAVSVPNSPTAAAISISGPAGRVTDAATEKIVPVLQQVAEELSVALSSSGVGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K392</accession>
    <name>A0A2M9K392_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Chloride channel protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CG723_03285</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CB01635</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000001">
        <property type="protein sequence ID" value="PJN13595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN13595">
        <property type="protein sequence ID" value="PJN13595"/>
        <property type="gene ID" value="CG723_03285"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005247">
        <property type="term" value="F:voltage-gated chloride channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014743">
        <property type="entry name" value="Cl-channel_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001807">
        <property type="entry name" value="Cl-channel_volt-gated"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00654">
        <property type="entry name" value="Voltage_CLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00762">
        <property type="entry name" value="CLCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81340">
        <property type="entry name" value="SSF81340"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="78"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="130"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="225"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="267"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="300"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="339"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="381"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="407"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="437"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="469"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="16"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="496"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="20"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="496"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="516"/>
            <end position="550"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PJN13595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="561" mass="57226" checksum="39770A1407905300" modified="2018-04-25" version="1">MFTARVVPRHRGLVRAAGGQPCKRDRRATGRMPVEWAQRDRGGTRANPDAGPGSGPWWRHPLTPPPDDSLPRWIVPSALIGVVAGLGAAALFGLLHLCTRWILEYVGGYHPYLTSAEGGFRTLTGSSHPWVVPLVAAGGALLATLLVVWLAPEARGHGTDAAIAAAHHDPSGMRGRVTVVKLMASALTIGSGGSGGTEGPAAQISAAFGSVIARRTGMTRQQARTALVIGLASGVGAIFQAPLGGALLGAELLYRKDMDPKVLPQALIAACTGWLAFGAIFGFAPILGAQSVHGYGFTDFVLVAVVGVAAGLAGRLYAGTFYAVHNRVESRARTVVSRLAAPTCAALLVGALGLAVPGVLGTGYGLMEALTHRQVLLDMPLYLVLLLPFAKIVGTSLTVGSGGSGGIFGPCMVVGAGVGAAVWRLAEPSGLAPHSPLLLVVAGMAACLGPVAHAPLGVLLMAVEMVGDASLLGPGILAVLCASAVIGRTTLYRSQLEHRTDEPSTGTRLPRPGHDRPEPSAPAVPPTAPAPKPSPEPMPAAAPSPAPEPVARSVSPESAAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K3I8</accession>
    <name>A0A2M9K3I8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Amino acid permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CG723_03825</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CB01635</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000001">
        <property type="protein sequence ID" value="PJN13682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN13682">
        <property type="protein sequence ID" value="PJN13682"/>
        <property type="gene ID" value="CG723_03825"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="41"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="68"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="117"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="149"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="179"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="212"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="254"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="316"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="370"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="396"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="443"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="491"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PJN13682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="521" mass="54716" checksum="521C811AE435F502" modified="2018-04-25" version="1">MTQAPPIPPTEPSATGAPDLPDLSEGWGEQRSRLKKDLRRLDVLFFLICTLVGLDTIGSVAAQGPQGLTWMAILALAFFLPYGLLVAELGSAFPVQGGPYVWTRLAFGRLVAGVNQLLYWISNPVWVGGSLCIIALTTWEEFFTPLPGLWKYAAGLVFIWGGALAVVQSVRIGKWVPIAGAVARIVLLGFFLISVVVFAVQHGVHALPAGEFVPTYAGFVALVPVLIFNYVGFELPSSAAEEMTNPRRDIPLSILRSGFAAVLLYGGPILGILFVLPSQEIGSLGGFIDACKAVFTVYGGSIAADGTVTLTGLGSVFGGVAAAGLIIGLLTSGVTWAMGAHRAQAVACADGAGPAWLGRISEKHGTPVRVNLLSAVLGSILFVVALNLTGGNGEKYFAAGLGLTICTTFISYVITFPSLAVLRRKYPDTPRPYAVPGGRVGAWVVSVLATGFVAFTVIVLIWPGFGVGWFGSAGNAADSLPESFAGERAQYTLSQVVPLVLFVGIGLVFYATGTRTRRRVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K3W3</accession>
    <name>A0A2M9K3W3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CG723_03935</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000001">
        <property type="protein sequence ID" value="PJN13813.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN13813">
        <property type="protein sequence ID" value="PJN13813"/>
        <property type="gene ID" value="CG723_03935"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039448">
        <property type="entry name" value="Beta_helix"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000421">
        <property type="entry name" value="FA58C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006626">
        <property type="entry name" value="PbH1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13229">
        <property type="entry name" value="Beta_helix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00754">
        <property type="entry name" value="F5_F8_type_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00710">
        <property type="entry name" value="PbH1"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="SSF49785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="SSF51126"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014786657" evidence="2">
        <location>
            <begin position="30"/>
            <end position="745"/>
        </location>
    </feature>
    <feature type="domain" description="Beta_helix" evidence="4">
        <location>
            <begin position="350"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="domain" description="F5/8 type C" evidence="3">
        <location>
            <begin position="628"/>
            <end position="733"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="26"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="624"/>
            <end position="654"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PJN13813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="745" mass="78979" checksum="3227A9A98FA4BDCE" modified="2018-04-25" version="1">MTPPMNGTRIAVALAATAALLSTAPAAHADPSPRVLHAAPDGSGTACTHGRPCSLDGARDAARTVEGRDVRVELADGTYALSRPLELGAADSGRDGHTVTWTAARGAHPVLSGGRTLKGWDSNTDGTWTTHVPEGVTPRQLFVDGVRAVRARGASCAASVCDATKTGMTGANATGIASWARPTDAEAVISVRWRNYHCRIDSVTGDVLTFAQPCWTNSASGTNRTGPAWDSTTVDSSRYAKVAYFENAPELLDQPGEFVWNSDARTLTYLPRKGEDMRRAKAVTPATERLLVLDGAHDVRVEGIGLQYAAWHQPSTDEGYAGMQAGLVLTGATGPADHAGRYYTKPSAALTVRGGRHVAVDQVEFSHLGGAGVVFEAGTQDSKVTRSRFTDLSSGAAYIGDTEPMPNAELVGARNTVAYNTIRRTGVEFTDAVGIWAGYEAATVIDHNTLDDLPYSGISVGWGWNQPEAQKSVLRDNRITNNRITNVMRVEHDQHDGGAIYTQGAQPGTVISGNYINRSAFGNTERDGNGIYLDEQSSHIRVEGNVLTRLGYKWVSNWADYGIDNHATGNWTDTDAPALAGTGSAMTDNHTKLDRLPADALKVAASAGAQGHDRVEQLRPDLARTGTAAQSSTDGTATAAAATDGDTSTDTRTLSEPGAWWQVDLGSVQHVGQVEVWNNTSMTTTGFDVQLSRTADFADTTTLQVPGKALRPTVLDAAKGTEARYVRIKLTGTGRVALAHVLVHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K422</accession>
    <name>A0A2M9K422_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CG723_02680</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000001">
        <property type="protein sequence ID" value="PJN13777.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN13777">
        <property type="protein sequence ID" value="PJN13777"/>
        <property type="gene ID" value="CG723_02680"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032823">
        <property type="entry name" value="BCA_ABC_TP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12399">
        <property type="entry name" value="BCA_ABC_TP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="24"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="56"/>
            <end position="63"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PJN13777.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="276" mass="29350" checksum="3E9127FA086E50D0" modified="2018-04-25" version="1">MPQEPDRNPNDARPDPGAPDIPPLHVRDLTVRFSGLTALDAVGFTVRPGTVHALIGPNGAGKSTCFNVLSGVYRATAGSVRFGEHELTGMSAHRIAGLGVARIFQNLALPPRDTVEDCLMLGRHRLTSAGFLAAGLRLPAAAREERRHRERVREIAAFVGIEHQLASPAGSLPYGQQKLAELARALCMEPRLLLLDEPVAGMTARERARTAGVIAGVRDSLGISIVLVEHDMGVVMRLADAVTVLDFGRLIADGTPDDVQNDPAVVRAYLGEGAAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JER5</accession>
    <name>A0A2M9JER5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Dienelactone hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_45550</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000057">
        <property type="protein sequence ID" value="PJN05302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN05302">
        <property type="protein sequence ID" value="PJN05302"/>
        <property type="gene ID" value="CG723_45550"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002925">
        <property type="entry name" value="Dienelactn_hydro"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01738">
        <property type="entry name" value="DLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DLH" evidence="1">
        <location>
            <begin position="20"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN05302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="245" mass="26068" checksum="F20EBE748614A9A9" modified="2018-04-25" version="1">MTTITTRTVEYPADGLTMIGHLALPAGVDRRPAVLLGPEGMGLSDVERRRADALAELGYVALAFDLHGGRYLGDPEEMLARCMPLLADPDRMRGIGHAALDVLRTEPRTDPDRIAAVGYGTGGAVGLELGRDGVDLRAIGTVNALTTGRPGEAARIRCPVWAGVGSEDPIMPPAQRNAFTAEMQAAGVDWRLTVYGGALHAFHHPPVDHPVVPGVGYHPQHAQRAWRDVVDLLAECLPVTEDLGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JES1</accession>
    <name>A0A2M9JES1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CG723_45135</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000050">
        <property type="protein sequence ID" value="PJN05394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN05394">
        <property type="protein sequence ID" value="PJN05394"/>
        <property type="gene ID" value="CG723_45135"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="129"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="domain" description="HTH cro/C1-type" evidence="3">
        <location>
            <begin position="13"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="158"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="194"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PJN05394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="422" mass="43817" checksum="94A878025E85CC12" modified="2018-04-25" version="1">MADVDATAEFAALLRGLKERSGLSYGVLAKRLHMSTSTLHRYCNGDAVPVDYAPVERLARLCKAGPEELVELHRLWVLADAARRTKPAAASEEPAAVAVDPVAVAVEPVAPVPDAEPVPAPERRRSRRVVVLAAALAVVVAGGAGAFAVHLAGDGGGDGGGDRKDHAGATSSATPGARSADPSGKASPSAGHERKPSASPSRSDNPAGDALGTPSAPAAGEGTGTPLTVATTPYVYESPCSQHFLIDRPPVKVPPPPLEQDAPNWVGVLGAVASGEQLIKLTVQGTGSDTVVLEDLDVRVMKSGAPLAWNDYSMGVGCGGNVETKSFGVDLDVPRPVSAPRNGQRDFPYKVSESDPEVFYIKANAKAHDVSWVLELKWSSGSRHGVLKIDNQGRAFRTSADVGRPGYDYPIGAGSWGERVDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-09-29" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JEW0</accession>
    <name>A0A2M9JEW0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_44530</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000048">
        <property type="protein sequence ID" value="PJN05430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN05430">
        <property type="protein sequence ID" value="PJN05430"/>
        <property type="gene ID" value="CG723_44530"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011044">
        <property type="entry name" value="Quino_amine_DH_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_repeat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50969">
        <property type="entry name" value="SSF50969"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="1">
        <location>
            <begin position="33"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN05430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="149" mass="15921" checksum="9DBEB9A8C5D51B76" modified="2018-04-25" version="1">MVGPDSTWLATRSNADTTVRLWDRASGQCTTTLTGHTDRVTSVAISPDGTWLAVSGDTTLRLWDRASGRCIKTLTAESGRVGSVAISPDSTWLASVSKSGEIRVCNVRSRAIATLVRTDGSLTGCTWASHGRTFVAVGIRGLHLFELRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JF39</accession>
    <name>A0A2M9JF39_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Sugar ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CG723_44475</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CB01635</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000047">
        <property type="protein sequence ID" value="PJN05511.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN05511">
        <property type="protein sequence ID" value="PJN05511"/>
        <property type="gene ID" value="CG723_44475"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="32"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="94"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="127"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="228"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="280"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="86"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PJN05511.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="313" mass="34702" checksum="D940DAF091290BDE" modified="2018-04-25" version="1">MATMLRTRPGRREHALRKGQLRNPAHRNDWRLALLLIAPAVLGFAVFAVYPTLRGVYLSFTDFKILTPPVWTGLDNIRTLIGDEKFWHSLRVTLYFVVLSVGIGLTVSLITAVVLHRLTKSTVVRGLVILPFLISGVVAGLVWQWMLDPQLGIVNVLIEKITGSPIEFLGSQTWAIPSVALISVWKSMGYSTVLIVAGLQTISPDVYEAGRLDGASEIQMFWRLTLPLLRPIMAMVVVLSVISSFQVFDIVAVTTKGGPADATNVLQMYIYDKAFGQFDFGYAATMSLALFAMLITITFLQMRLLRADESDTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JF67</accession>
    <name>A0A2M9JF67_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Acyl-CoA dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CG723_44325</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CB01635</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000046">
        <property type="protein sequence ID" value="PJN05545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN05545">
        <property type="protein sequence ID" value="PJN05545"/>
        <property type="gene ID" value="CG723_44325"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016627">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="SSF47203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="SSF56645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0274">FAD</keyword>
    <keyword evidence="3 5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA_dh_N" evidence="8">
        <location>
            <begin position="14"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_M" evidence="7">
        <location>
            <begin position="136"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_1" evidence="6">
        <location>
            <begin position="240"/>
            <end position="388"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PJN05545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="389" mass="42622" checksum="1B154302660BAA8C" modified="2018-04-25" version="1">MPYTLEPSYDDNPRLKELVERLRTYLTDELIPYERDRGITAESKLDRATLEHVWKRSAELGFYGISLPPELGGQGLHFTELCALKEELTASGAALSHSVLGDMGGPLRVGAIVKYATEQQMRHYLMPVIRGERACCFSITEQDAGSDVRRMSTTATPDGDTYVLNGHKVFSSAAPFADFAIVVVRMAGNQEAYSAFLVDLDSPGCRVLEGDVPMSGQQMEGDLVFEDCRIPAANLLGEIGQGLRIGIGRITLNRLLHCPSLIGAARRAWDLSVAHSKSRVAFGQPLLALQAVQHKLADMATDLYAARSMVLATATRADRGENIAVEANMCKLFTSEACFRVADQAVQIHGKTGLTRGHEVEQIFRTLRMFRIVTGTTEIHKNAIAKALV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JFD3</accession>
    <name>A0A2M9JFD3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CG723_43645</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000044">
        <property type="protein sequence ID" value="PJN05598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN05598">
        <property type="protein sequence ID" value="PJN05598"/>
        <property type="gene ID" value="CG723_43645"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021862">
        <property type="entry name" value="DUF3472"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11958">
        <property type="entry name" value="DUF3472"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PJN05598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="210" mass="21929" checksum="0F8A367C64A75C30" modified="2018-04-25" version="1">MINAYHSIAGAPSAGLSDISYHITVNSQPDTKSVFFAQAFYLKNGQVGYMGLQPRPGADDLALFSIFGAGTSTTDPNCTPGADGGEGVSCAITYPYQVGRQYRLKVQNVGGSKWEGIVYDTVTGATTHIGSWTVSSSAGLLKPTGTLFVEYFLPVTDCNSIPRAQAYFSNPQGNGSTYRGSYSSAVLLGPCKDKASYSISSAGITTVTGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JFG1</accession>
    <name>A0A2M9JFG1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">TetR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CG723_43870</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000044">
        <property type="protein sequence ID" value="PJN05630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN05630">
        <property type="protein sequence ID" value="PJN05630"/>
        <property type="gene ID" value="CG723_43870"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="3">
        <location>
            <begin position="22"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="44"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PJN05630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="231" mass="25796" checksum="303E3634B184CED0" modified="2018-04-25" version="1">MSHHHAPSAKETPTKPLRRDAQRNRDAIVAAARTAFSEQGLGASLEGIAREAGIAIGTLYRHFPTRLDLVETLFNAKYAELLTAAEEAAAMDDAWEGFCRYLENLCKLQACDRAFNDLVSARLPLHVAGREMFERTKDLCNQIMRNAQEQGVLRSDVTAQDIAFVIWSQAGIIQATRTVAPQAWRRHLHLMLDAFRTEGAHELPEPPLTSQQVDQTLVTLECTEEGCREQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JFR1</accession>
    <name>A0A2M9JFR1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_43465</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000043">
        <property type="protein sequence ID" value="PJN05672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN05672">
        <property type="protein sequence ID" value="PJN05672"/>
        <property type="gene ID" value="CG723_43465"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023869">
        <property type="entry name" value="tRNA_Adeno_NH3ase_assoc_put"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03941">
        <property type="entry name" value="tRNA_deam_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="91"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="101"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN05672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="183" mass="19396" checksum="789D6229FF9ABBFC" modified="2018-04-25" version="1">MYFAALLARTEDGWEASDTELDDVEALSDLTDLAREASAGAEDDTVLVFIEQEDAWFGVVRVDGEEDPRIYVSDAAAAARSSYGEILLTDELLGKDPDQDELDALDLDGTEDGEPDPADEDEAGDDDAADPAAEAVPPGPIGDRLILADLGVSEKELLALDTNDALSEIAEVLGAAEVLETVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JFW1</accession>
    <name>A0A2M9JFW1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GNAT family N-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_43590</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000043">
        <property type="protein sequence ID" value="PJN05693.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN05693">
        <property type="protein sequence ID" value="PJN05693"/>
        <property type="gene ID" value="CG723_43590"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013653">
        <property type="entry name" value="FR47"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08445">
        <property type="entry name" value="FR47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="149"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN05693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="290" mass="31631" checksum="3C16065B04E3D5F2" modified="2018-04-25" version="1">MRPYDWHLTEDIDDFLARAGDFLRSRPALHTTPLTSTEKLRALGTEAYRAHAPAFGTLERAGEVRAVFYRFTQHGPLSLTPLAPEDAEALAELLAGLGHVLPTVSAAHDTSTAFAEAWQRHTGATPTLSTRIRLYRLGTLTPPEPVPAGRGRRVGAQDREQLFRWHREFAADVGEDVTIDADTWAGTRFGDKHYTFWETPDGTPVSMAGMTSLVGGMVRVDPVYTPAHLRGRGYAGAVTVEVTRAALAAGAKEVALYANPANATSNALYQRIGYVPLTEWAVYDFAAVRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-06-02" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JG23</accession>
    <name>A0A2M9JG23_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Peptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_42645</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000040">
        <property type="protein sequence ID" value="PJN05834.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN05834">
        <property type="protein sequence ID" value="PJN05834"/>
        <property type="gene ID" value="CG723_42645"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.70.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011055">
        <property type="entry name" value="Dup_hybrid_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016047">
        <property type="entry name" value="Peptidase_M23"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01551">
        <property type="entry name" value="Peptidase_M23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51261">
        <property type="entry name" value="SSF51261"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase_M23" evidence="2">
        <location>
            <begin position="243"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="108"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="152"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="25"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="169"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN05834.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="350" mass="35957" checksum="160EC68302F6945C" modified="2018-04-25" version="1">MASNRPAPEFSYAPIDEEFGEADERTWDEWNPTEESVRPVRGRHRVAKQRGGLARSSTVLGVGVIAAVGAGGIATAQGGKPPVHISMPDLSAVKNSLPDAKSLPGVGALISDGSDDDSSGADAAPLTGAGITTADAEQGTTAGEALRARIMQQAEQQQDQAADAEAAAAEEAAAKKAAEDAAKERDAASAKAAAEKKKAEEAAKKKAEAERLAKLAKSFTLPVASYTITGTFGQPGSMWSSGYHTGLDFAAPTGTPLKAIHSGTVKEAGWAGAYGYRTVLELPDGTELWYCHQSSLNVSAGQKVTSGDVIGRVGATGNVTGPHLHLEVHPGGQATGVDPAPWLRSNGLTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JG42</accession>
    <name>A0A2M9JG42_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Hydroxyglutarate oxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_42665</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000040">
        <property type="protein sequence ID" value="PJN05838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN05838">
        <property type="protein sequence ID" value="PJN05838"/>
        <property type="gene ID" value="CG723_42665"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DAO" evidence="1">
        <location>
            <begin position="8"/>
            <end position="393"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN05838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="409" mass="43818" checksum="073D3A25397016F5" modified="2018-04-25" version="1">MTSGYDCDVLVIGGGIVGLSTAYALTRAVPGTRVTVLEKERGPARHQTGRNSGVIHSGVYYRPGSLKARFAVRGAAEMVKFCEQYGVAHAVTGKLIVATERDELPRLHALVQRGRENGIPVRELGPAQIGEYEPYVRGLAAIHVGTTGVADYASVARHLAEASGADIRYGAEVVQIDRRAERGVAVRTAAGDVVRGRVLVNCAGLHCDRIARLAGDDPGMRIVPFRGEYFELARPELVRGLVYPVPDPAFPFLGVHLTRGIDKSVHVGPNAVPALALEGYDWSTVRPRELGATLAWPGSWRIARRHWRYGAGELRRSVSRDAFTAAVRRLLPAVTADDLVPAPAGVRAQAVLRDGTLVDDFLIREAPRTVHVLNAPSPAATASLPIGREVARRALAALGSQAAGCELRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-09-29" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JG87</accession>
    <name>A0A2M9JG87_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Acyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_42380</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000039">
        <property type="protein sequence ID" value="PJN05899.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN05899">
        <property type="protein sequence ID" value="PJN05899"/>
        <property type="gene ID" value="CG723_42380"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002656">
        <property type="entry name" value="Acyl_transf_3_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01757">
        <property type="entry name" value="Acyl_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="30"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="73"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="122"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="153"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="214"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="244"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="274"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="312"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl_transf_3" evidence="2">
        <location>
            <begin position="1"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN05899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="352" mass="39628" checksum="4B3E9D18536A1510" modified="2018-04-25" version="1">MRFIAALAVFVHHTTGLAPGKGLAQAPVLFPYSTMGVNGVGFFFVLSGFLLAWGHRPGTRRGLFYWRRAGRIWPAHLAATIPCIWVFYLWGGVPTDAFSFVTSLLLVQTWFPGVVPMFPGNGVAWTLSVEVFFYLLFPWVIGPALRLRTRTLALLAASGLAAMWAVNWWAAAHLSPFAREWVMRHPVTRLPEFAVGLVCAIALRRGHRIALRPAALLAAFAAYTAVYCHRIVWFSPDTVGQLEWTVRPFVAVFSALFIVAYAQRELSGRRGALCSRPMVLLGAWSYAFYLLHQTLNRYVQDTWGRMRPDNSALFTLCGLAVAVIALSWALFTYVEEPARKWWSRHTPRRLTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JGH7</accession>
    <name>A0A2M9JGH7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Lysine decarboxylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CG723_42130</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000038">
        <property type="protein sequence ID" value="PJN05943.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN05943">
        <property type="protein sequence ID" value="PJN05943"/>
        <property type="gene ID" value="CG723_42130"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1780.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003462">
        <property type="entry name" value="ODC_Mu_crystall"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023401">
        <property type="entry name" value="ODC_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13812">
        <property type="entry name" value="PTHR13812"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02423">
        <property type="entry name" value="OCD_Mu_crystall"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001439">
        <property type="entry name" value="CryM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PJN05943.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="341" mass="36306" checksum="01B3B740E10EB6EB" modified="2018-04-25" version="1">MVAAVGRDDLMGRIIDRLAEGFAEIGRGARELSPLRDGFERTEPVRGIFEWMPHRDPGDSITLKTVGYSPGNPKHFGLPTIIGTVARYDDSTGALTALMDGVLLTALRTGAASAVASRLLARPDSRTLGLIGAGAQAVTQLHALSLVFPLERVLVWDTDPAHRDSFARRAAFTGIPVQCADPARIAAEADIITTATSVPTGGGPVLPDGPHREHLHINAVGADLIGKTELPLSLLRRAFVTADHPEQAHREGECQRLAPHQTGPGLTRLAAEPALAHERRGALTVFDSTGFAFEDALAMEVFLEAAAEHGLGSRLQIEHHPADTVDPYALQPLPVASPARH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JGS0</accession>
    <name>A0A2M9JGS0_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Transport permease protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CG723_41555</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CB01635</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the ABC-2 integral membrane protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000036">
        <property type="protein sequence ID" value="PJN06080.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN06080">
        <property type="protein sequence ID" value="PJN06080"/>
        <property type="gene ID" value="CG723_41555"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046677">
        <property type="term" value="P:response to antibiotic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC_2_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000412">
        <property type="entry name" value="ABC_2_transport"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01061">
        <property type="entry name" value="ABC2_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006648">
        <property type="entry name" value="DrrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51012">
        <property type="entry name" value="ABC_TM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0046">Antibiotic resistance</keyword>
    <keyword evidence="8" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="25"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="66"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="111"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="149"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="180"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="236"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="domain" description="ABC2_membrane" evidence="9">
        <location>
            <begin position="13"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PJN06080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="263" mass="27954" checksum="CBED0234FBB889DA" modified="2018-04-25" version="1">MSSLSLAVRDSSTMLRRNLLHARRYPSLTLNLLLTPIMLLLLFVYIFGDVMSAGIGGGGADRSEYIAYIVPGLLLMTIGSTTIGTAVSVSNDMTEGIIARFRTMAIHRGSVLIGHVIGSVLQSIASVVLVGAVGVAIGFRSTDATVLEWVAAFGLLVLFATALTWIAVGMGLISPNAEAASNNAMPLILLPLLSSAFIPTDTMPGWFQPIAEYQPFTPAIETLRGLLLGSEIGSNGWIAVAWCMGLTVLGYYWSKAKFNSDPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JGY2</accession>
    <name>A0A2M9JGY2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CG723_41075</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000035">
        <property type="protein sequence ID" value="PJN06136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN06136">
        <property type="protein sequence ID" value="PJN06136"/>
        <property type="gene ID" value="CG723_41075"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PJN06136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="176" mass="20404" checksum="1EADAF71380025B6" modified="2018-04-25" version="1">MATHDRETMAEVWTTLQAIKMRADRAVREAAEALFQRVAMIADPGATGTWARWVDDLEMEGAERPDLEQEFGTDLSRDHDVRFLSALDDFITLARLDLLRRWWHSLLPGPVRRWYMGRKHGNQHGGPGRPWKQPRVELRLSEDVLARVDDAKRNFFDTRGRTLRRLIAKGLEAESE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-05-25" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JHV4</accession>
    <name>A0A2M9JHV4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Cold shock domain protein CspD</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CG723_39420</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CB01635</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000031">
        <property type="protein sequence ID" value="PJN06337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN06337">
        <property type="protein sequence ID" value="PJN06337"/>
        <property type="gene ID" value="CG723_39420"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04458">
        <property type="entry name" value="CSP_CDS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012156">
        <property type="entry name" value="Cold_shock_CspA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011129">
        <property type="entry name" value="CSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019844">
        <property type="entry name" value="CSD_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002059">
        <property type="entry name" value="CSP_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00313">
        <property type="entry name" value="CSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002599">
        <property type="entry name" value="Cold_shock_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00050">
        <property type="entry name" value="COLDSHOCK"/>
    </dbReference>
    <dbReference type="SMART" id="SM00357">
        <property type="entry name" value="CSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00352">
        <property type="entry name" value="CSD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51857">
        <property type="entry name" value="CSD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CSD" evidence="3">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU000408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PJN06337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="67" mass="7290" checksum="1F9C53041655A569" modified="2018-04-25" version="1">MATGTVKWFNSEKGFGFIEQEGGGPDVFAHYSNIATQGFRELQEGQKVNFDVTQGQKGPQAENIVPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JI00</accession>
    <name>A0A2M9JI00_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_38900</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000029">
        <property type="protein sequence ID" value="PJN06511.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN06511">
        <property type="protein sequence ID" value="PJN06511"/>
        <property type="gene ID" value="CG723_38900"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011045">
        <property type="entry name" value="N2O_reductase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011964">
        <property type="entry name" value="YVTN_b-propeller_repeat"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50974">
        <property type="entry name" value="SSF50974"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02276">
        <property type="entry name" value="beta_rpt_yvtn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014618161" evidence="2">
        <location>
            <begin position="30"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="37"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN06511.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="397" mass="43314" checksum="5A201370A6C2E1E5" modified="2018-04-25" version="1">MTPRRTRTAAVLIAAVTVLAALAGCGTDAKEHRATEALGTHGAKAVKPKPKPVAQGLPGMPPVLDPKDIYAADRPGKLSPVVKDFPSRIYVPNTESDTVSVIDPRTYKVIETINVGSQPQHVVPSWDMKTLWVNNDKGNTLTPIDPKTGRVGKTVDVHDPYNLYFTPDGKYSIVMASLDRELVFRDAHTMKPFKTVPVSCYGVNHADFSADGRYFIVSCEFSGEILKVDTAKMKVVGQERLPFEGAMPQDVKLSPDGKTFYIADMKANGMWVLDGKKFTTPKLLPTGKGAHGLYVSRDSREMYISNRGEGTISIFDFAKNELTKKWTLPDGGSPDMGGVSSDGKILWLSGRYDSEVYAIDTRTGKQIARIPVGDGPHGLAVYPQPGRYSLGHTGIFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JI12</accession>
    <name>A0A2M9JI12_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Enoyl-CoA hydratase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_38915</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the enoyl-CoA hydratase/isomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000029">
        <property type="protein sequence ID" value="PJN06514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN06514">
        <property type="protein sequence ID" value="PJN06514"/>
        <property type="gene ID" value="CG723_38915"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.12.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018376">
        <property type="entry name" value="Enoyl-CoA_hyd/isom_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014748">
        <property type="entry name" value="Enoyl-CoA_hydra_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00166">
        <property type="entry name" value="ENOYL_COA_HYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN06514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="255" mass="27107" checksum="7A3E3370AF15F1DC" modified="2018-04-25" version="1">MTAYLEVAEGVGTIRLDRPPMNALDIATQDRIKELAEEASRRDDVRAVVVRGSDKAFAAGADIKEMQAMDHAAMIVRSRALQDSFTAVARIPKPVVAAVTGYALGGGCELALCADFRIAADNAKLGQPEILLGLIPGAGGTQRLARLVGPSKAKDLIFTGRQVKAEEALAIGLVDRVVPAAEVYEQAHAWAAKLAQGPALALRAAKESIDVGLETDIDTGLAVERNWFAGLFATEDRERGMRSFVEEGPGKAKFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JIX8</accession>
    <name>A0A2M9JIX8_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Aminodeoxyfutalosine synthase</fullName>
            <shortName evidence="6">AFL synthase</shortName>
            <shortName evidence="6">Aminofutalosine synthase</shortName>
            <ecNumber evidence="6">2.5.1.120</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Menaquinone biosynthetic enzyme MqnE</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">mqnE</name>
        <name evidence="8" type="ORF">CG723_37280</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CB01635</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3-[(1-carboxyvinyl)oxy]benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>3-[(1-carboxyvinyl)-oxy]benzoate + H2O + S-adenosyl-L-methionine = 6-amino-6-deoxyfutalosine + H(+) + hydrogencarbonate + L-methionine</text>
            <dbReference type="Rhea" id="RHEA:33075"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:64286"/>
            <dbReference type="ChEBI" id="CHEBI:76981"/>
            <dbReference type="EC" id="2.5.1.120"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="6">Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.</text>
    </comment>
    <comment type="pathway">
        <text evidence="6">Quinol/quinone metabolism; menaquinone biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the radical SAM superfamily. MqnE family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.120" evidence="6"/>
    <dbReference type="EMBL" id="NNBL01000026">
        <property type="protein sequence ID" value="PJN06737.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN06737">
        <property type="protein sequence ID" value="PJN06737"/>
        <property type="gene ID" value="CG723_37280"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00079"/>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102573">
        <property type="term" value="F:aminodeoxyfutalosine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009234">
        <property type="term" value="P:menaquinone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00993">
        <property type="entry name" value="MqnE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045567">
        <property type="entry name" value="CofH/MnqC-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaB/NifB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034405">
        <property type="entry name" value="F420"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020050">
        <property type="entry name" value="FO_synthase_su2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022432">
        <property type="entry name" value="MqnE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43076">
        <property type="entry name" value="PTHR43076"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19288">
        <property type="entry name" value="CofH_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00343">
        <property type="entry name" value="aminofutalosine_synthase_(mqnE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03700">
        <property type="entry name" value="mena_SCO4494"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00423">
        <property type="entry name" value="TIGR00423"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 6" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="4 6" id="KW-0408">Iron</keyword>
    <keyword evidence="5 6" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="6" id="KW-0474">Menaquinone biosynthesis</keyword>
    <keyword evidence="3 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Radical SAM core" evidence="7">
        <location>
            <begin position="52"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="66"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="70"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="73"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PJN06737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="387" mass="44366" checksum="D6C4F72269E19D79" modified="2018-04-25" version="1">MDVGLKRELEQKVRDGERLSREDGVALYESDDLAWLGGLAHEVRTRKNGDVVHFNVNRHLNMTNVCTASCAYCSFQRKPGEKDAYTMRIEEAVRLAKAMENENLTELHIVNGLHPTLPWRYYPRSLKALKEALPNVALKAFTATEIHHFETISGLSASEILDELIDAGLESLTGGGAEIFDWEIRQHIVDHATHWEDWSRIHRLAHEKGLKTPSTMLYGHIEEPRHRVDHVLRLRELQDETGGFQVFIPLRYQHDFVDMKDGKVRNRLQARTTMATGAEALKTFAVSRLLFDNVPHVKCFWVMHGVQTTQLALQHGADDMDGSVVEYKITHDADNYGTPNKLTREDLLDLIRDAGFRPVERNTRYEIIREYDGPDPARRETPQAMRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JJ36</accession>
    <name>A0A2M9JJ36_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Membrane dipeptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CG723_37010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000025">
        <property type="protein sequence ID" value="PJN06880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN06880">
        <property type="protein sequence ID" value="PJN06880"/>
        <property type="gene ID" value="CG723_37010"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070573">
        <property type="term" value="F:metallodipeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01301">
        <property type="entry name" value="rDP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008257">
        <property type="entry name" value="Pept_M19"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10443">
        <property type="entry name" value="PTHR10443"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01244">
        <property type="entry name" value="Peptidase_M19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51365">
        <property type="entry name" value="RENAL_DIPEPTIDASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PJN06880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="395" mass="42565" checksum="443E4ADF6E2841B7" modified="2018-04-25" version="1">MTTSLERARAILADFPVVDGHNDLPWALREQVAYDIDARDIAVDQSAHLHTDLARLRAGGVGAQFWSVYVRSDMAGDVAVSATLEQIDCVQQLIERYPADLRRALTAADMEAARTEGRIASLMGAEGGHSIDNSLATLRALHTLGVRYMTLTHNDNIAWADSATDEPGVGGLSPFGHEVVREMNRAGMLVDLSHVAATTMRAALDTSVAPVIFSHSSSRAVCDHPRNIPDDVLERLPANGGVAMATFVPKFVLQAAVDWTAAADENLRAHGFHHLDTSPEAMKLHRAFEEARPRPVATVSTVADHLDHMREVAGVDHIGIGGDYDGTAFLPDGLGDVSGYPNLIAELVDRGWSDPDLAKLTWQNAVRVLGAAEDVARDEQSRRGPSNATLEQLDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JJ64</accession>
    <name>A0A2M9JJ64_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_37130</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000025">
        <property type="protein sequence ID" value="PJN06903.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN06903">
        <property type="protein sequence ID" value="PJN06903"/>
        <property type="gene ID" value="CG723_37130"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021888">
        <property type="entry name" value="DUF3499"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12005">
        <property type="entry name" value="DUF3499"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="114"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="134"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN06903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="150" mass="16048" checksum="4B1AAAE1BDD5C28C" modified="2018-04-25" version="1">MRTTTRWGDLPGSRRGPLKSAVPSNAVSPVRRCSRTACGRPAVATLTYVYADSTAVLGPLATYAEPHCYDLCAEHSERLTAPRGWEVVRLADSSGPSRPSGDDLEALANAVREAARPRERAAEAGGGPRTADPMEVARRGHLRVLRSPDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JJK7</accession>
    <name>A0A2M9JJK7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Aldehyde dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CG723_35555</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CB01635</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000023">
        <property type="protein sequence ID" value="PJN07050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN07050">
        <property type="protein sequence ID" value="PJN07050"/>
        <property type="gene ID" value="CG723_35555"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016620">
        <property type="term" value="F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016160">
        <property type="entry name" value="Ald_DH_CS_CYS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="SSF53720"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00070">
        <property type="entry name" value="ALDEHYDE_DEHYDR_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00687">
        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldedh" evidence="5">
        <location>
            <begin position="25"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="253"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PJN07050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="485" mass="52192" checksum="17DD690662197391" modified="2018-04-25" version="1">MSYFTELAQQYIDGSWRPGRGAWDIIDFNPYSGDKLASITVASADEVDEAYRAAERAQKSWADTNAYTRRLVFERALRLVEEREDEISDAIVDELGGTRLKAGFELHLAKEFLRESIQLALRPQGRVIPSPVDGKENRLYRVPVGVVGVISPFNFPFLLSLKSVAPALALGNGVVLKPHQNTPICGGSLVAKIFEDAGLPAGLLNVVITDIAEIGDALLTHPVPKVISFTGSDAVGQHVATVCASQFKHAVLELGGNSALTVLDDADIDYAVDAAVFSRYVHQGQVCMAANRILVDRKVEKEFTEKFVAKVRSLKVGDPRDPSTVIGPVINSTQAEVVSGVVDQALAEGATALLHGKAVGNLVEPSILTDLPADSPVLRQEIFGPVALLIPFDGDEEAVAIANDTPYGLSGAVHTRDVERGVAFARRIDTGMIHVNDGTVHDEPLVAFGGEKRSGLGRLNGEATVEAFTTQKWISVQHGRSQFPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JK05</accession>
    <name>A0A2M9JK05_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7">Nuclease SbcCD subunit D</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">sbcD</name>
        <name evidence="10" type="ORF">CG723_35015</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CB01635</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">SbcCD cleaves DNA hairpin structures. These structures can inhibit DNA replication and are intermediates in certain DNA recombination reactions. The complex acts as a 3'-&gt;5' double strand exonuclease that can open hairpins. It also has a 5' single-strand endonuclease activity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2 7">Heterodimer of SbcC and SbcD.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the SbcD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000022">
        <property type="protein sequence ID" value="PJN07203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN07203">
        <property type="protein sequence ID" value="PJN07203"/>
        <property type="gene ID" value="CG723_35015"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008408">
        <property type="term" value="F:3'-5' exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00840">
        <property type="entry name" value="MPP_Mre11_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP_ApaH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041796">
        <property type="entry name" value="Mre11_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004593">
        <property type="entry name" value="SbcD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026843">
        <property type="entry name" value="SbcD_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12320">
        <property type="entry name" value="SbcD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="SSF56300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00619">
        <property type="entry name" value="sbcd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="7" id="KW-0235">DNA replication</keyword>
    <keyword evidence="7" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="6 7 10" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="5 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 7" id="KW-0540">Nuclease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Metallophos" evidence="8">
        <location>
            <begin position="1"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="domain" description="SbcD_C" evidence="9">
        <location>
            <begin position="267"/>
            <end position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU363069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF12320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PJN07203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="387" mass="41856" checksum="F7D7731B08FC9C34" modified="2018-04-25" version="1">MRLLHTSDWHLGRAFHRVNMLGAQAEFIGHLVATVRERDVDAVVVSGDVYDRAVPPLAAVELFDDALHRLAEQGIPTVMISGNHDSARRLGVGAGLIGRAGIHLRTDPGACATPVLIPDATGDVAFYGLPYLEPALVKDEFAVSKPGHEAVLAAAMGRVRADLAERPAGTRSVVLAHAFVTGGEASDSERDITVGGVAAVPSGVFDGVDYVALGHLHGSQVISERVRYSGSPLPYSFSEADHRKSMWLVDLDADGFAAAERVDCPVPRPLARIRGDLADLLARPDLATHEEAWVEATLTDPVRPDDPMARLTERFPHTLSLAFDPQRAPEDPDVSYAQRLKGRDDQQIAEDFVSHVRGAGPDERERAVLREALDAVRVDDTRREVAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JLC0</accession>
    <name>A0A2M9JLC0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Metal-dependent hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_32880</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000019">
        <property type="protein sequence ID" value="PJN07665.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN07665">
        <property type="protein sequence ID" value="PJN07665"/>
        <property type="gene ID" value="CG723_32880"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016516">
        <property type="entry name" value="UCP07580"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39456">
        <property type="entry name" value="PTHR39456"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10118">
        <property type="entry name" value="Metal_hydrol"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF007580">
        <property type="entry name" value="UCP07580"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="194"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN07665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="294" mass="32934" checksum="2478C948F3F67F66" modified="2018-04-25" version="1">MTPRRVSFDWETTPLHWIPGEPTATHVINVLHLLLPAGERWFVKVFKEGLPLVDDPELLGDVKGFMGQEATHSVQHAYVLDHLAAQRLDTADFTKYVDFLFEKLLGERPPLGAPVSTQEWLRFRLSVVAAIEQFTAVLGNWVLHAEGLDAADSDEVMLDLLRWHGAEEVEHRAVAFDMYQHCGGAGLPRYARRLAGMAVTAPVMLYLWAWGAAYLIRHDPQLAGRMRYSLAEHNRAVRKGLLPSWRELGAAIPRYLRRSYHPSQEGSLRKAVEYLAQSPAARTAAGAIGRTALS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JLG7</accession>
    <name>A0A2M9JLG7_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Uroporphyrinogen-III C-methyltransferase</fullName>
            <ecNumber evidence="2">2.1.1.107</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">cobA</name>
        <name evidence="10" type="ORF">CG723_32100</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CB01635</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the precorrin methyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.107" evidence="2"/>
    <dbReference type="EMBL" id="NNBL01000018">
        <property type="protein sequence ID" value="PJN07715.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN07715">
        <property type="protein sequence ID" value="PJN07715"/>
        <property type="gene ID" value="CG723_32100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043115">
        <property type="term" value="F:precorrin-2 dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051266">
        <property type="term" value="F:sirohydrochlorin ferrochelatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004851">
        <property type="term" value="F:uroporphyrin-III C-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009236">
        <property type="term" value="P:cobalamin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019354">
        <property type="term" value="P:siroheme biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11642">
        <property type="entry name" value="SUMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.950.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1010.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000878">
        <property type="entry name" value="4pyrrol_Mease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035996">
        <property type="entry name" value="4pyrrol_Methylase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014777">
        <property type="entry name" value="4pyrrole_Mease_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014776">
        <property type="entry name" value="4pyrrole_Mease_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006366">
        <property type="entry name" value="CobA/CysG_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012409">
        <property type="entry name" value="Sirohaem_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003043">
        <property type="entry name" value="Uropor_MeTrfase_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00590">
        <property type="entry name" value="TP_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036426">
        <property type="entry name" value="Sirohaem_synth"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53790">
        <property type="entry name" value="SSF53790"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01469">
        <property type="entry name" value="cobA_cysG_Cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00840">
        <property type="entry name" value="SUMT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8 10" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-0627">Porphyrin biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4 8 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="TP_methylase" evidence="9">
        <location>
            <begin position="171"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="7">
        <location>
            <position position="201"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="7">
        <location>
            <position position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR036426-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PJN07715.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="411" mass="43112" checksum="15CF8163F0F5627B" modified="2018-04-25" version="1">MAAEHPAYPVGLRLTGRRVVVLGGGQVAQRRLPALIAAGADIHLVSPTATPSVEAMADGGELTWSRRPYADGDLADAWYALIATGDRTANEAASAEAERHRVWCVRSDDADAATAWTPATGRSEGVTVAVLTTDAAGRDPRHTAAVRDAIVEGLRDGTLVAPHHRKRTTGVSLVGGGPGDPDLITVRGRRLLAEADVVIADRLGPRDLLDELPPHVEVIDAAKIPYGRYMAQEAINNALIEHAKQGKAVVRLKGGDPYVFGRGMEEAIALEAEGIPYTVVPGISSSISVPGAAGIPVTHRGVAHEFTVVSGHVAPDDERSLVDWPALAKLRGTLVVLMGVDKIGRIAETLIAHGKSAQTPVALVQEGTTAAQRRVDATLETVEDAVRTHEVRPPAVIVIGDVVAVGPQHTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JLM6</accession>
    <name>A0A2M9JLM6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NADPH-dependent ferric siderophore reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_32460</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000018">
        <property type="protein sequence ID" value="PJN07780.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN07780">
        <property type="protein sequence ID" value="PJN07780"/>
        <property type="gene ID" value="CG723_32460"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013113">
        <property type="entry name" value="FAD-bd_9_SIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007037">
        <property type="entry name" value="SIP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039374">
        <property type="entry name" value="SIP_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30157">
        <property type="entry name" value="PTHR30157"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08021">
        <property type="entry name" value="FAD_binding_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04954">
        <property type="entry name" value="SIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="SSF63380"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding FR-type" evidence="1">
        <location>
            <begin position="10"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN07780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="277" mass="30472" checksum="94B2ADE9564B968B" modified="2018-04-25" version="1">MAERPERRKPTAHRGEVLRTERLTPHMQRVVLGGDGLAAFAAGGCTDHYVKLQFPLDGVTYPEPFDLGRIREELPRDQWPVTRTYTVRAWDPVARELTLDFVVHGDEGIAGPWARDVQPGASVHLAGPGGAYAPDSTADWHLLAGDESALPAIAAALEALPEDAVAHAFVEVSDATEEQKIDSAAQVVWLHRGGRPVGEALVEAVRGLAFPAGRVHAFVHGEAGFVKELRRHLRTEREIPREDLSISGYWRLGHNEDGWQASKRDWNAQVEAEQETA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JLP5</accession>
    <name>A0A2M9JLP5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">WYL domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_32550</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000018">
        <property type="protein sequence ID" value="PJN07796.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN07796">
        <property type="protein sequence ID" value="PJN07796"/>
        <property type="gene ID" value="CG723_32550"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028349">
        <property type="entry name" value="PafC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043839">
        <property type="entry name" value="PafC_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026881">
        <property type="entry name" value="WYL_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19187">
        <property type="entry name" value="HTH_PafC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13280">
        <property type="entry name" value="WYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016838">
        <property type="entry name" value="PafC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH_PafC" evidence="2">
        <location>
            <begin position="8"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="domain" description="WYL" evidence="1">
        <location>
            <begin position="144"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF19187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN07796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="318" mass="34605" checksum="18A200B54927A45D" modified="2018-04-25" version="1">MATNAIDQTRRMLSLVTYLRERPGARVGDVARAFGITEDELISDLDILPLCGTSFRGGDLLDIDTDGDRIWWHNPDDVAAPLRLAADEATALLVAARAVSTLPGLRESDRLALLRATAKLEAAAGEAAGASARLSVTFESEGGVFADVDRAISERRRLWIRYYSPARDELTEREIDPIRLVSVGHTYVEAWCRRSEARRTFRLDRVAEIRILDEASAPPQIELRDLSEGLVQPAAEDPEVVVEVGPGGRWVAEYYPHDSAEELAGGGLRITLRTPDPSSLKRLALRLGRDGRIVSPVGVAESARQAAGEALAAYDGQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-09-29" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JLV1</accession>
    <name>A0A2M9JLV1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_31015</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000017">
        <property type="protein sequence ID" value="PJN07838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN07838">
        <property type="protein sequence ID" value="PJN07838"/>
        <property type="gene ID" value="CG723_31015"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046423">
        <property type="term" value="F:allene-oxide cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009695">
        <property type="term" value="P:jasmonic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.480.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044859">
        <property type="entry name" value="Allene_oxi_cyc_Dirigent"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034871">
        <property type="entry name" value="Allene_oxi_cyc_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141493">
        <property type="entry name" value="SSF141493"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014657305" evidence="1">
        <location>
            <begin position="28"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN07838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="166" mass="17395" checksum="A829F40C99E1CABF" modified="2018-04-25" version="1">MMRPIGAACLGTATLVTLLACTPVAAAATDTGSAQARGKARIITLLAEVQQLTRFPVTPGSVSQGDQVVVRSDLFDKAHNKVGETHGTCTTTRGGADEAEQCVVTYTLPGGQLTVQGMYFNYVDQGPFDNAITGGTGKYEKARGSVHAATIATDPKVVRRFTIHLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-09-29" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JM46</accession>
    <name>A0A2M9JM46_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CG723_31800</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CB01635</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000017">
        <property type="protein sequence ID" value="PJN07960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN07960">
        <property type="protein sequence ID" value="PJN07960"/>
        <property type="gene ID" value="CG723_31800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="25"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="58"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="82"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="117"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="144"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="191"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="226"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="253"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="279"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="315"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="351"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="1"/>
            <end position="386"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PJN07960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="386" mass="38727" checksum="EDD9DB5E871B90B3" modified="2018-04-25" version="1">MSLLAASSAPTPLYAIYQAEWGFDPITTTVVFGVYAVAVLLGLLTMGKLSDHVGRRPVLLAALAAQATSMVVFATADGVSGLVMARIVQGLSTGAALGAIGAGMMDIDRPRGTITNAVVPGIGTATGALVSGLVVQFLPAPTHLVYLGLLAVFVLQAVAVALMAETVIRKPGALASLAPEIKLPRAVRRPMLVAAPVLFAVWALAGLYGSLGPSLARQLTGSGSEILGGLSLFVLAGVAAVSVLVLRKAATRTVMLTGILALIAGVALTLVSIRGSSSTGFFVGTAIAGVGFGSGFQGGIRTVMPLARPHESSGVLSLLFIVSYLGMGVPAVIAGFLVVHGGGLTATAQEYGGAVIVLAAFALLRLERGGRDGAAVLPGERVGGNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JM70</accession>
    <name>A0A2M9JM70_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">FMN reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_31565</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000017">
        <property type="protein sequence ID" value="PJN07952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN07952">
        <property type="protein sequence ID" value="PJN07952"/>
        <property type="gene ID" value="CG723_31565"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005025">
        <property type="entry name" value="FMN_Rdtase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03358">
        <property type="entry name" value="FMN_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52218">
        <property type="entry name" value="SSF52218"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FMN_red" evidence="1">
        <location>
            <begin position="7"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN07952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="198" mass="21249" checksum="C87E23187E196AC1" modified="2018-04-25" version="1">MEKIKHKLVIIVGSVRDGRFGPVVASWVVEQAGIHGGFDVEVVDLAEIDIPLALPAASPKFAGDDYPRPAGMAALTSALENADAFIVVTPEYNHSYPASLKAAIDWHFTQWTAKPVAFVSYGGAAGGRHAVLHLENVLTELHAVTIRDGLAFPNYFTAWQDGHPLAPEAPGYAKTLLDQLAWWAAALRSARNAAPYPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JMK8</accession>
    <name>A0A2M9JMK8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">CopY family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_30215</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the BlaI transcriptional regulatory family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000016">
        <property type="protein sequence ID" value="PJN08098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08098">
        <property type="protein sequence ID" value="PJN08098"/>
        <property type="gene ID" value="CG723_30215"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005650">
        <property type="entry name" value="BlaI_family"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34134">
        <property type="entry name" value="PTHR34134"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03965">
        <property type="entry name" value="Penicillinase_R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN08098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="109" mass="11750" checksum="8FFEC2CEAE36B076" modified="2018-04-25" version="1">MEAEILTLLHSAGRALTPGDVAELLTASPAHTTVATTLARLHSRGVLDRTPLGRSYAYEPVSDESGLTARHMHQVMEAGTDRASVLTHFVDELSDDDEDLLRRLLGSDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JMT8</accession>
    <name>A0A2M9JMT8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GNAT family N-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_29730</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000015">
        <property type="protein sequence ID" value="PJN08186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08186">
        <property type="protein sequence ID" value="PJN08186"/>
        <property type="gene ID" value="CG723_29730"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="193"/>
            <end position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN08186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="341" mass="36357" checksum="C8BC4475A195D34D" modified="2018-04-25" version="1">MEFTAGGRLELRLTASDVGKRVSVRRLTEVGSPGAKFTDTVGVLTSWNDGVLLITKRGGEQVHIPESSLVAGKVVPSAPARRRGPAASYEELARAAARAWQPVESERLGGWELRAAGGFTRRANSVLPLGDPGLPLDEALTRVRAWYERRGLPAYIQTATGAEGTQELLCAELEARGWVREVSAEMWVGGLAPVADGVDLGDRVGLTREPGEAWLGRYQRKGASEVALKVLTTGPSVWFATVPGGGGEPDAIGRCVVDGRWAGFAAVEVAPSRRREGLASAVMTALARRALEEGASAAWLQVEADNEGARALYGRLGFAAHHAYHHYRAPEPDRDPDSAGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JMW9</accession>
    <name>A0A2M9JMW9_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Iron-sulfur cluster carrier protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CG723_29820</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CB01635</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the Mrp/NBP35 ATP-binding proteins family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">In the C-terminal section; belongs to the Mrp/NBP35 ATP-binding proteins family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">In the N-terminal section; belongs to the MIP18 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000015">
        <property type="protein sequence ID" value="PJN08204.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08204">
        <property type="protein sequence ID" value="PJN08204"/>
        <property type="gene ID" value="CG723_29820"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140663">
        <property type="term" value="F:ATP-dependent FeS chaperone activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02040">
        <property type="entry name" value="Mrp_NBP35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034904">
        <property type="entry name" value="FSCA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002744">
        <property type="entry name" value="MIP18-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019591">
        <property type="entry name" value="Mrp/NBP35_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000808">
        <property type="entry name" value="Mrp_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044304">
        <property type="entry name" value="NUBPL-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033756">
        <property type="entry name" value="YlxH/NBP35"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42961">
        <property type="entry name" value="PTHR42961"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01883">
        <property type="entry name" value="FeS_assembly_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10609">
        <property type="entry name" value="ParA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117916">
        <property type="entry name" value="SSF117916"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01215">
        <property type="entry name" value="MRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FeS_assembly_P" evidence="6">
        <location>
            <begin position="4"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="119"/>
            <end position="126"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PJN08204.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="377" mass="38935" checksum="8590E364539E256D" modified="2018-04-25" version="1">MATEDAVREALATVNDPEIQRPITELGMVKSVEIDADGAVAVTVYLTVSGCPMRETITKNVTDAVAAVEGVTRVDVTLDVMGDEQRKELATALRGGTAEREVPFAKPGSLTRVYAVASGKGGVGKSSVTVNLAAAMAADGLKVGVVDADIYGHSVPRMLGAEGRPTQVENMIMPPSANGVKVISIGMFTPGNAPVVWRGPMLHRALQQFLADVFWGDLDVLLLDLPPGTGDIAISVAQLVPNAEILVVTTPQQAAAEVAERAGSIAVQTHQKIVGVVENMAGLPCPHCGEMVDVFGTGGGERVAEGLTRTTGANVPVLGSIPIDVRLREGGDEGKPVVLTDPDSPAGSALRAIAGKLGGRARGLSGMSLGITPRNKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JN78</accession>
    <name>A0A2M9JN78_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">VKc domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CG723_28445</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">CB01635</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the VKOR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000014">
        <property type="protein sequence ID" value="PJN08323.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08323">
        <property type="protein sequence ID" value="PJN08323"/>
        <property type="gene ID" value="CG723_28445"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd12922">
        <property type="entry name" value="VKOR_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1440.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012932">
        <property type="entry name" value="VKOR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041714">
        <property type="entry name" value="VKOR_Actinobacteria"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038354">
        <property type="entry name" value="VKOR_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07884">
        <property type="entry name" value="VKOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00756">
        <property type="entry name" value="VKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-0874">Quinone</keyword>
    <keyword evidence="9" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="50"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="75"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="102"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="145"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="domain" description="VKc" evidence="11">
        <location>
            <begin position="1"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PJN08323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="172" mass="19549" checksum="89787FF6D8841CC6" modified="2018-04-25" version="1">MLAAWVITIDKFKLLEDPNFTPGCSLNPVVSCGNIMKSEQASAFGFPNPMLGLAAYAVVICVGMSLLGRASFPRWYWLTFNAGTLFGVGFCTWLQFQSLYRINSLCLWCSLAWVATIVMFWYVTSFNVRNGFLPAPSWLRSFFGEFTWVLPVLHVGIIGMLILTRWWDFWTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JNL6</accession>
    <name>A0A2M9JNL6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_29220</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000014">
        <property type="protein sequence ID" value="PJN08456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08456">
        <property type="protein sequence ID" value="PJN08456"/>
        <property type="gene ID" value="CG723_29220"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="44"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN08456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="74" mass="7664" checksum="FFCBC6C447ABDFC3" modified="2018-04-25" version="1">MPPEEPQAREDGSDEQQVQPSARPTGVPVDTAARTPRPTVAEPVVPGVGVLPLGSGLVLVGLGVGFLALRLRRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-09-29" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JP84</accession>
    <name>A0A2M9JP84_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Lipid-transfer protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_26650</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000012">
        <property type="protein sequence ID" value="PJN08679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08679">
        <property type="protein sequence ID" value="PJN08679"/>
        <property type="gene ID" value="CG723_26650"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002155">
        <property type="entry name" value="Thiolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020616">
        <property type="entry name" value="Thiolase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00108">
        <property type="entry name" value="Thiolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000429">
        <property type="entry name" value="Ac-CoA_Ac_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thiolase_N" evidence="1">
        <location>
            <begin position="9"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN08679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="383" mass="40630" checksum="BF4BB0B3817C0E34" modified="2018-04-25" version="1">MAGLKDATAIVGIGQTPFGKQLPESEKTLACRAILAALDDAGIAPSEVDAFASYTMEETDEVEVAKAVGAGDVTFFSKVGFGGGGSCATVAHLAAAVATGQASVGVAWRSRKRGSGPRPWKNTAVQLPTPAQWTRPYGLLRPADEIAMLARRYMHEYGATRDHLFNVALACRNRANQNPAAMMYERPLTRDMYMTARMISEPLCLFDNCLETDGALACVIVSAERARDCRQKPVYVHSVAQGLPSQHHGMVNYWNDDPLTGPAWTAARHLWKQADFGPEDVDVAQIYDAFTPLIPLSLEGYGFCGRGEGGAFTEGGALEIGGRLPLNTGGGGLSEAYVHGFNLINEGVKQLRGISTAQVPDAGTCLVTAGEGVPTSALLLRGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-06-02" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JPS5</accession>
    <name>A0A2M9JPS5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_27365</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000012">
        <property type="protein sequence ID" value="PJN08797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08797">
        <property type="protein sequence ID" value="PJN08797"/>
        <property type="gene ID" value="CG723_27365"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="125"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="135"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="183"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN08797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="272" mass="27387" checksum="75387585979CD8CB" modified="2018-04-25" version="1" fragment="single">MVTFAQAQERAEEWINGDVPGYQHREVRVREFELGFVVWAEDRDGGPVSDGGRQRLVIARDSGDASLWPGLPVGEVIRRYEEEYGLPEASPEPSDAPPERVDLNQTSFLLSPPEWLQEAADKLGIPDRRGDASSAGGSGASSGAGTGAVSGTGTGTGSGASVPGPAAPAPVAADAGSGATPWPASPATPSGATPWAGTDTNADEEEDRSVAPPATVFAPPLVDEGDVPAPTAAPEARTALMSGGSQLPRTAVAPALDGSAPAAPGAPTPGAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JPU0</accession>
    <name>A0A2M9JPU0_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">ATP synthase subunit c</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">ATP synthase F(0) sector subunit c</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">F-type ATPase subunit c</fullName>
            <shortName evidence="13">F-ATPase subunit c</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Lipid-binding protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13 15" type="primary">atpE</name>
        <name evidence="15" type="ORF">CG723_25665</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">CB01635</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12 13">F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.</text>
    </comment>
    <comment type="function">
        <text evidence="13">Key component of the F(0) channel; it plays a direct role in translocation across the membrane. A homomeric c-ring of between 10-14 subunits forms the central stalk rotor element with the F(1) delta and epsilon subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="13">Cell membrane</location>
            <topology evidence="13">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the ATPase C chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000011">
        <property type="protein sequence ID" value="PJN08884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08884">
        <property type="protein sequence ID" value="PJN08884"/>
        <property type="gene ID" value="CG723_25665"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045263">
        <property type="term" value="C:proton-transporting ATP synthase complex, coupling factor F(o)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01396">
        <property type="entry name" value="ATP_synth_c_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005953">
        <property type="entry name" value="ATP_synth_csu_bac/chlpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000454">
        <property type="entry name" value="ATP_synth_F0_csu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020537">
        <property type="entry name" value="ATP_synth_F0_csu_DDCD_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038662">
        <property type="entry name" value="ATP_synth_F0_csu_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002379">
        <property type="entry name" value="ATPase_proteolipid_c-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035921">
        <property type="entry name" value="F/V-ATP_Csub_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10031">
        <property type="entry name" value="PTHR10031"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00137">
        <property type="entry name" value="ATP-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00124">
        <property type="entry name" value="ATPASEC"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81333">
        <property type="entry name" value="SSF81333"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01260">
        <property type="entry name" value="ATP_synt_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00605">
        <property type="entry name" value="ATPASE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 13" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="13" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 13" id="KW-0138">CF(0)</keyword>
    <keyword evidence="6 13" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="8 13" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 13" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="10 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 13" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="17"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="57"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-synt_C" evidence="14">
        <location>
            <begin position="20"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="site" description="Reversibly protonated during proton transport" evidence="13">
        <location>
            <position position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00025198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01396"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="PJN08884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="79" mass="7806" checksum="BB53059BE497A70E" modified="2018-04-25" version="1">MSATIELAAGVTGSLGSIGYGLAAIGPGIGVGIVFGNGTQALARQPEAAGLIRANQILGFAFCEALALIGIVMPFVFGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JPY3</accession>
    <name>A0A2M9JPY3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">PadR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_26005</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000011">
        <property type="protein sequence ID" value="PJN08939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08939">
        <property type="protein sequence ID" value="PJN08939"/>
        <property type="gene ID" value="CG723_26005"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005149">
        <property type="entry name" value="Tscrpt_reg_PadR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03551">
        <property type="entry name" value="PadR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PadR" evidence="2">
        <location>
            <begin position="14"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="121"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="172"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="311"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="128"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="172"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="311"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN08939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="346" mass="38761" checksum="37E1CBC7AC58D39D" modified="2018-04-25" version="1">MPPVFAHGRLRLYLLKLLDEAPRHGYEVIRLLEERFQGLYAPSAGTVYPRLAKLEAEGLVTHTTEGGRKVYSITDAGRAELADRSGELADLELEIRESVAELAAEIRDDVRGAAGDLRREMRAAASKARNGSGTTTGKSERQNPFGDFQDFGDKEAWRAAKEELRRARQEWKEQARRAKDESRRAREEAQRARRQAKEAQEQAREQAQEQVQRLAQRVQDQVQDHFAQGDWPTGVREGLTELAKEFGDFGKYFGKETGGAARSEGAGPEVRVTHGDIPAEYLPSWTHEDPTGDPARDLDRLLDRFRDDIRDAARDHGVSEDQLREARSRLSEAAAHIGASLQAPKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JQ28</accession>
    <name>A0A2M9JQ28_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_26220</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000011">
        <property type="protein sequence ID" value="PJN08981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08981">
        <property type="protein sequence ID" value="PJN08981"/>
        <property type="gene ID" value="CG723_26220"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN08981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="231" mass="23724" checksum="71BA039A8EC2F037" modified="2018-04-25" version="1">MLLAGCGDGGHGGSGARGDGGNKRPSASGVDGTADPAKVFTDAELGAALLPAEAVGKGAKALEVSLGLFDQGSGGGDWSTCVAGRDAHGELWRMRGASAERTFRPDPAAVGEDDPFVYERLVSMPAGRAGRYLELRRELHEACGRVTVDTDGALAEEHHEVRSLPDLGDEAVLETTRTTGGDEYDGSAHYVVELRVGGVLVIVGAGTDMDLTLSSAAEAARWVGKGLYGAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JQ78</accession>
    <name>A0A2M9JQ78_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">3-phosphoshikimate 1-carboxyvinyltransferase</fullName>
            <ecNumber evidence="7">2.5.1.19</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">5-enolpyruvylshikimate-3-phosphate synthase</fullName>
            <shortName evidence="7">EPSP synthase</shortName>
            <shortName evidence="7">EPSPS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7 9" type="primary">aroA</name>
        <name evidence="9" type="ORF">CG723_26300</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CB01635</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>3-phosphoshikimate + phosphoenolpyruvate = 5-O-(1-carboxyvinyl)-3-phosphoshikimate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:21256"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57701"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="ChEBI" id="CHEBI:145989"/>
            <dbReference type="EC" id="2.5.1.19"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 7">Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 6/7.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the EPSP synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.19" evidence="7"/>
    <dbReference type="EMBL" id="NNBL01000011">
        <property type="protein sequence ID" value="PJN08995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08995">
        <property type="protein sequence ID" value="PJN08995"/>
        <property type="gene ID" value="CG723_26300"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00053">
        <property type="reaction ID" value="UER00089"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003866">
        <property type="term" value="F:3-phosphoshikimate 1-carboxyvinyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009073">
        <property type="term" value="P:aromatic amino acid family biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008652">
        <property type="term" value="P:cellular amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009423">
        <property type="term" value="P:chorismate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01556">
        <property type="entry name" value="EPSP_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.65.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00210">
        <property type="entry name" value="EPSP_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001986">
        <property type="entry name" value="Enolpyruvate_Tfrase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036968">
        <property type="entry name" value="Enolpyruvate_Tfrase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006264">
        <property type="entry name" value="EPSP_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023193">
        <property type="entry name" value="EPSP_synthase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013792">
        <property type="entry name" value="RNA3'P_cycl/enolpyr_Trfase_a/b"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00275">
        <property type="entry name" value="EPSP_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000505">
        <property type="entry name" value="EPSPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55205">
        <property type="entry name" value="SSF55205"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01356">
        <property type="entry name" value="aroA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00104">
        <property type="entry name" value="EPSP_SYNTHASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00885">
        <property type="entry name" value="EPSP_SYNTHASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="6 7" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="EPSP_synthase" evidence="8">
        <location>
            <begin position="17"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="region of interest" description="Shikimate-3-phosphate binding" evidence="7">
        <location>
            <begin position="30"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Phosphoenolpyruvate" evidence="7">
        <location>
            <begin position="102"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Shikimate-3-phosphate binding" evidence="7">
        <location>
            <begin position="178"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="7">
        <location>
            <position position="326"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="7">
        <location>
            <position position="354"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="35"/>
        </location>
        <ligand>
            <name>3-phosphoshikimate</name>
            <dbReference type="ChEBI" id="CHEBI:145989"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="132"/>
        </location>
        <ligand>
            <name>phosphoenolpyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="207"/>
        </location>
        <ligand>
            <name>3-phosphoshikimate</name>
            <dbReference type="ChEBI" id="CHEBI:145989"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="357"/>
        </location>
        <ligand>
            <name>phosphoenolpyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="398"/>
        </location>
        <ligand>
            <name>phosphoenolpyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="423"/>
        </location>
        <ligand>
            <name>phosphoenolpyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PJN08995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="438" mass="45859" checksum="DC84BF2C782183F7" modified="2018-04-25" version="1">MTEIPVHTSLWPAPHASGPVFATVHVPGSKSVTNRALVLAALAAEPGWLRRPLRSRDTLLMAAALRAMGVGIEEGVGPDGSGEAWRVIPSGLRGPATVDVGNAGTVMRFLPPVAALADGSVRFDGDPRSYERPLNGVIDALRVLGARIDDDSRGSLPMTVHGTGALDGGRVEIDASSSSQFVSALLLSAPRFNQGVEMRHVGGPLPSMPHIRMTVDMLRTVGAQVDTPESGGEPNVWRVTSGALLGRDLTVEPDLSNAQPFLAAALVTGGKVTVPDWPERTTQPGDRLREIFTLMGGSCELTGQGLEFTGSGAIHGIDVDLSEVGELTPGIAAVAALADSPSTLRGVAHLRLHETDRLAALTKEINELGGDVTETADGLHIRPRRLHGGIFHTYDDHRMATAGAIIGLAVPGVEIENVGTTAKTLPDFPDLWAGMLGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JQV0</accession>
    <name>A0A2M9JQV0_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Maleate isomerase</fullName>
            <ecNumber evidence="1">5.2.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Maleate cis-trans isomerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">maiA</name>
        <name evidence="2" type="ORF">CG723_23160</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes cis-trans isomerization of the C2-C3 double bond in maleate to yield fumarate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>maleate = fumarate</text>
            <dbReference type="Rhea" id="RHEA:13169"/>
            <dbReference type="ChEBI" id="CHEBI:29806"/>
            <dbReference type="ChEBI" id="CHEBI:30780"/>
            <dbReference type="EC" id="5.2.1.1"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="miscellaneous">
        <text evidence="1">Reaction is initiated by nucleophilic attack of cysteine at the double bond, yielding a covalent succinylcysteine-like intermediate.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the maleate isomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.1" evidence="1"/>
    <dbReference type="EMBL" id="NNBL01000009">
        <property type="protein sequence ID" value="PJN09256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN09256">
        <property type="protein sequence ID" value="PJN09256"/>
        <property type="gene ID" value="CG723_23160"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050076">
        <property type="term" value="F:maleate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00943">
        <property type="entry name" value="Maleate_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026286">
        <property type="entry name" value="MaiA/AMDase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028615">
        <property type="entry name" value="Maleate_isomerase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40267">
        <property type="entry name" value="PTHR40267"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17645">
        <property type="entry name" value="Amdase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015736">
        <property type="entry name" value="MI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="1">
        <location>
            <begin position="80"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="1">
        <location>
            <begin position="199"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="1">
        <location>
            <position position="80"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="1">
        <location>
            <position position="198"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="14"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="137"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="167"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="modified residue" description="S-(2-succinyl)cysteine" evidence="1">
        <location>
            <position position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN09256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="256" mass="27045" checksum="B719236BDD525458" modified="2018-04-25" version="1">MTDHHIGLIVPSSNLTMETELPRMLHARETVEPGDRFVFHSSRMRMKHVTPEELRGMNAQTERAASELADARPDVVATACLVAIMAQGPGYHCTAEAEITAALQAESAEAPVVSSAGALLSGIEALGAQRVAIITPYMKPLTAKVVAYIEDAGIEVVDALSLEVPDNLAVARLNPADLREHHRRLDLSRADALVLSACVQMPSLASIQTVEDETGLPVLSAATATAYRILQELGLPPVVPGAGSLLGGRSAELAAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JRA9</accession>
    <name>A0A2M9JRA9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Phage tail protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CG723_24145</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000009">
        <property type="protein sequence ID" value="PJN09416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN09416">
        <property type="protein sequence ID" value="PJN09416"/>
        <property type="gene ID" value="CG723_24145"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011747">
        <property type="entry name" value="CHP02241"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010667">
        <property type="entry name" value="Phage_T4_Gp19"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38009">
        <property type="entry name" value="PTHR38009"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06841">
        <property type="entry name" value="Phage_T4_gp19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02241">
        <property type="entry name" value="TIGR02241"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PJN09416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="174" mass="19684" checksum="A59B6395D03A20A1" modified="2018-04-25" version="1">MPEITRRDPFKNFRFRVKFSGSTEYIAGISKVSGLKRTTEVIKHRDGGDPGSSHKLPGRTEYEAITLERGCTIDTAFEEWANRVWSLRNSAGGLETSLKDFRRDLIIDVFDEAGQQVLSYSVHDCWVSEYQGLPDLDANANGVAFEHIKLEHHGWVRERTNPPQQPQFSDTASG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JRI4</accession>
    <name>A0A2M9JRI4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Phosphoesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_22130</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000008">
        <property type="protein sequence ID" value="PJN09473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN09473">
        <property type="protein sequence ID" value="PJN09473"/>
        <property type="gene ID" value="CG723_22130"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003951">
        <property type="term" value="F:NAD+ kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017438">
        <property type="entry name" value="ATP-NAD_kinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001206">
        <property type="entry name" value="Diacylglycerol_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016064">
        <property type="entry name" value="NAD/diacylglycerol_kinase_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00781">
        <property type="entry name" value="DAGK_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00046">
        <property type="entry name" value="DAGKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111331">
        <property type="entry name" value="SSF111331"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50146">
        <property type="entry name" value="DAGK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DAGKc" evidence="2">
        <location>
            <begin position="196"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="317"/>
            <end position="345"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN09473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="523" mass="54678" checksum="FA11672C9C8CE1B2" modified="2018-04-25" version="1">MKRPGRLWKIPGTGSRLAGVLARSRAVRGNSATDLLRSVAGHDAVWLAAATVLGMSGGRSARRAALRGIGSVAIVVAIDRALAKPAARSTRPVLDALTGVFPRSSTVSLPSSPMTSAAAFASGVVLESPRYGLAVMPFAAGLTYVRGREGLDHRGRVAVGVIVGMGAALLTCRWWPVKPEAAASAAPPRRPAPALVAGKGLHLVVNSSSGISWSQDTAETLRTMLPEAAIAVFEPGDDLVALLDEAAMRAVADGGALGVCGGDGTVNAGSATAARHHVPLAVFPGGTFNHFAVDLGNQTLEDVARAIRAGDAVTADVGRASSPKSPCTRLEAGAPNGSPDDSAGVFPSGGEQQLFLNTFSIGVYSELVHARERMEKRIGKWPALAVGLAKVLATGTPLSVVINGRPRSIWLLFAGNGIYHPAGFAPTYRTQLDDGLLDVRAVEAGTPLARTRLLLAVLTGTLHNSRVLTTAQVRRLDLEVLQGEPHFAYDGEVTDATYRRLVLDKIPKAVTLYRPADQDQWLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JSC5</accession>
    <name>A0A2M9JSC5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">FAD-dependent oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_21510</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000007">
        <property type="protein sequence ID" value="PJN09776.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN09776">
        <property type="protein sequence ID" value="PJN09776"/>
        <property type="gene ID" value="CG723_21510"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DAO" evidence="1">
        <location>
            <begin position="45"/>
            <end position="402"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN09776.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="475" mass="51904" checksum="E081B189A91FBBA9" modified="2018-04-25" version="1">MAARAMNRGTDWIKSLADAKPLSYWLDDPGKPQAQPALTGDERCDLLVVGGGYSGLWTALLAKERDPGRDVVLLEGQEVGWAASGRNGGFCAASLTHGVANGLARWPGEIAKLEELGNRNLDAIEEAVARYSIDCDFERTGELDVATEPHQATELQEFHQELTEAGLADGTELLDADATREQVDSPTFLGALYDRRGVAMLHPAKLAWGLKQACLDLGVRFYEHTPALELSSSGAGTAVRTPYGRVFAQHVALGTNVFPSLVKRVRSYTVPVYDYALMTEPLTDDQLASIGWKNRQGLGDSANQFHYFRLSADNRILWGGYDAIYPYGGRVRAEYDHRPETYAKLAGQFFTCFPQLEGARFSHAWGGAIDTCSRFSAFFGTAHKGRVAYAAGYTGLGVGATRFGADVMLDLLSGERTERTELEMVRTKPLPFPPEPFAYTGIALTKWSLARADDNGGRRNLWLKAMDKAGLGFDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-06-02" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JT69</accession>
    <name>A0A2M9JT69_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 6">Transcription termination/antitermination protein NusG</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">nusG</name>
        <name evidence="10" type="ORF">CG723_20470</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CB01635</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5 6">Participates in transcription elongation, termination and antitermination.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5 6">Belongs to the NusG family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000006">
        <property type="protein sequence ID" value="PJN10086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN10086">
        <property type="protein sequence ID" value="PJN10086"/>
        <property type="gene ID" value="CG723_20470"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006354">
        <property type="term" value="P:DNA-templated transcription, elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006353">
        <property type="term" value="P:DNA-templated transcription, termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032784">
        <property type="term" value="P:regulation of DNA-templated transcription, elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031564">
        <property type="term" value="P:transcription antitermination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.940">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00948">
        <property type="entry name" value="NusG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005824">
        <property type="entry name" value="KOW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006645">
        <property type="entry name" value="NGN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036735">
        <property type="entry name" value="NGN_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043425">
        <property type="entry name" value="NusG-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_L2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001062">
        <property type="entry name" value="Transcrpt_antiterm_NusG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015869">
        <property type="entry name" value="Transcrpt_antiterm_NusG_bac_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30265">
        <property type="entry name" value="PTHR30265"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30265:SF2">
        <property type="entry name" value="PTHR30265:SF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02357">
        <property type="entry name" value="NusG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00338">
        <property type="entry name" value="NUSGTNSCPFCT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00739">
        <property type="entry name" value="KOW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00738">
        <property type="entry name" value="NGN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="SSF50104"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82679">
        <property type="entry name" value="SSF82679"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00922">
        <property type="entry name" value="nusG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01014">
        <property type="entry name" value="NUSG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5 6" id="KW-0804">Transcription</keyword>
    <keyword evidence="2 5 6" id="KW-0889">Transcription antitermination</keyword>
    <keyword evidence="3 5 6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="1 5 6" id="KW-0806">Transcription termination</keyword>
    <feature type="domain" description="NGN" evidence="8">
        <location>
            <begin position="112"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="domain" description="KOW" evidence="9">
        <location>
            <begin position="248"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="12"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="47"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PJN10086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="302" mass="33143" checksum="A84582C1B9836D00" modified="2018-04-25" version="1">MSDPNLNEAIEPVESAEDELDIVEAADAENAEDTVQAETADEAATEADAHVEDEVEAAEESLEHAAEDDADEESAEDAPEAEADEESVEEAAEESEPVDPIVALREELRTLPGEWYVIHTYAGYENRVKTNLEQRAVSLNVEDFIFQAEVPQEEVAQIKNGERKTVRQNKLPGYVLVRMDLTNESWGVVRNTPGVTGFVGNAYDPYPLTLDEIVKMLAPEAEEKAAREAAEAEGRPAPSRKVEVQVLDFEVGDSVTVTDGPFATLQATINEINADSKKVKGLVEIFGRETPVELSFDQIQKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JT99</accession>
    <name>A0A2M9JT99_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_20685</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000006">
        <property type="protein sequence ID" value="PJN10121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN10121">
        <property type="protein sequence ID" value="PJN10121"/>
        <property type="gene ID" value="CG723_20685"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="41"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="41"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN10121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="66" mass="7502" checksum="C4303DD4070BD65C" modified="2018-04-25" version="1">MAISDKDPYNARETARVLLLAARAVRREARGKSIRGIEKQAARIREEAQDREDARAAARRKARGKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JTE6</accession>
    <name>A0A2M9JTE6_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 6">NH(3)-dependent NAD(+) synthetase</fullName>
            <ecNumber evidence="4 6">6.3.1.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">nadE</name>
        <name evidence="9" type="ORF">CG723_20580</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CB01635</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4 6">
            <text>ATP + deamido-NAD(+) + NH4(+) = AMP + diphosphate + H(+) + NAD(+)</text>
            <dbReference type="Rhea" id="RHEA:21188"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:58437"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.3.1.5"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4 7">Cofactor biosynthesis; NAD(+) biosynthesis; NAD(+) from deamido-NAD(+) (ammonia route): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4 5">Belongs to the NAD synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.1.5" evidence="4 6"/>
    <dbReference type="EMBL" id="NNBL01000006">
        <property type="protein sequence ID" value="PJN10102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN10102">
        <property type="protein sequence ID" value="PJN10102"/>
        <property type="gene ID" value="CG723_20580"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00253">
        <property type="reaction ID" value="UER00333"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004359">
        <property type="term" value="F:glutaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003952">
        <property type="term" value="F:NAD+ synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008795">
        <property type="term" value="F:NAD+ synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009435">
        <property type="term" value="P:NAD biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00553">
        <property type="entry name" value="NAD_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00193">
        <property type="entry name" value="NadE_ammonia_dep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022310">
        <property type="entry name" value="NAD/GMP_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003694">
        <property type="entry name" value="NAD_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022926">
        <property type="entry name" value="NH(3)-dep_NAD(+)_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23090">
        <property type="entry name" value="PTHR23090"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02540">
        <property type="entry name" value="NAD_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00552">
        <property type="entry name" value="nadE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 5" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 5" id="KW-0520">NAD</keyword>
    <keyword evidence="2 4 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD_synthase" evidence="8">
        <location>
            <begin position="29"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="51"/>
            <end position="58"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="57"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="148"/>
        </location>
        <ligand>
            <name>deamido-NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58437"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="168"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="173"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="181"/>
        </location>
        <ligand>
            <name>deamido-NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58437"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="188"/>
        </location>
        <ligand>
            <name>deamido-NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58437"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="197"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="219"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="268"/>
            <end position="269"/>
        </location>
        <ligand>
            <name>deamido-NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58437"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU004252"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PJN10102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="276" mass="29915" checksum="914BFB40467CAAA0" modified="2018-04-25" version="1">MSESASNDLQQEIARELQVAETFEAEREIERRVAFLTERLTSTGLRSLVLGISGGVDSTTAGRLCQLAVERARAAGHEARFYAMRLPYGIQADEHDAQLALSFIRADHVLTVDIKPASDAAIEAALAADVNFRDEGHQDFVHGNIKARQRMVAQYAVAGAHNGLVVGTDHAAEAVSGFFTKFGDGAADLVPLTGLTKRRVRAVADSLGAPAELVWKVPTADLETLDPGKADEDALGVTYDDIDDFLEGKPVDGRAFETIVHRYRLTDHKRQLPIAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-09-29" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JTH5</accession>
    <name>A0A2M9JTH5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Chitinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CG723_17445</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CB01635</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the glycosyl hydrolase 18 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000005">
        <property type="protein sequence ID" value="PJN10185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN10185">
        <property type="protein sequence ID" value="PJN10185"/>
        <property type="gene ID" value="CG723_17445"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011583">
        <property type="entry name" value="Chitinase_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001223">
        <property type="entry name" value="Glyco_hydro18_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001579">
        <property type="entry name" value="Glyco_hydro_18_chit_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00704">
        <property type="entry name" value="Glyco_hydro_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00636">
        <property type="entry name" value="Glyco_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01095">
        <property type="entry name" value="GH18_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51910">
        <property type="entry name" value="GH18_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="1 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014805978" evidence="5">
        <location>
            <begin position="34"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="domain" description="GH18" evidence="6">
        <location>
            <begin position="46"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU004453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PJN10185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="351" mass="36948" checksum="06D3967521B2E576" modified="2018-04-25" version="1">MSRRSRTSRLLGAALAAAASLSTVLVAAPDAPAADTCATKPRPAGKVLQGYWENWDGASNGVHPPFGWTPITNPEMAQHGYNVINAAFPVIRSDGTALWEDGMDTNVKVATPAEMCQAKASGQTVLMSIGGAAAGIDLNSTAVADHFVETIVPILKKYNFDGIDIDIETGLTGSGNISQLSTSQANLIRIIDGILAQMPAGFGLTMAPETAYVTGGSVTYGSIWGAYLPIIKKYADNGSLWWLNMQYYNGSMYGCSGDSYEAGTVQGFTAQTDCLNKGLVVQGTTIKVPYDKQVPGLPAQPGAGGGYMAPSLVSQAWNTYGDGLKGLMTWSINWDGSKGWTFGDNVKGLEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-09-29" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JTL8</accession>
    <name>A0A2M9JTL8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_17375</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000005">
        <property type="protein sequence ID" value="PJN10178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN10178">
        <property type="protein sequence ID" value="PJN10178"/>
        <property type="gene ID" value="CG723_17375"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="77"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="102"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="225"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="255"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="288"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="312"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="351"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="378"/>
            <end position="396"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN10178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="415" mass="43306" checksum="5B30698816EDB105" modified="2018-04-25" version="1">MKGRRALGRRFGWLWAAFAVSSYGTGFGFGAFPLIAILVLHSGPTQVAALAAAGRAVGAVVAVPLGPWMEFRRKRPVMIAMDLIRFAALMSVPAAFAFGRLSFAQLLVVSVVVAAADIAFRAAGGAYLKSLVAPEDLLVANGRFESTTWTSIVVGPPLGGAAIGMFGPVTTVVADAVSYLLSALGIRAIGGTETRPARAAAPRLRAGDLLEGWRYILSHRTLRPLFLNSIVVNGLIMASEPLIAVLMLSRLGFAPWQYGLAFAAPCIGGLIGSRVAHPLVARFGQHKVMLVVGALRACWPIGLAFVQPGVPGIVLVVAVQLGLVTCCGLFNPVLATYRLEHADPDRVARTLSAWSVSSSLSIAALTAVWGVVAAITGPRIAIALAGVVLLATPLLLPRREKAPRSTGEQAAASLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JTV4</accession>
    <name>A0A2M9JTV4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Sugar ABC transporter substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_18105</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000005">
        <property type="protein sequence ID" value="PJN10299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN10299">
        <property type="protein sequence ID" value="PJN10299"/>
        <property type="gene ID" value="CG723_18105"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006059">
        <property type="entry name" value="SBP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01547">
        <property type="entry name" value="SBP_bac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014987166" evidence="1">
        <location>
            <begin position="29"/>
            <end position="437"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN10299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="437" mass="46256" checksum="DFDA69676473CFD8" modified="2018-04-25" version="1">MQRIRALASSAVVVSLLAAATACGGGSSDEGSNESPKTLTYWASNQGPNVEADKKILQPELDKFEKQTGIKVKLEVVPWSDLLTRILTATTSGEGPDVLNIGNTWSSSLQATGALVPWDQKNFDKIGGKDRFVESALGSTGAQGKDPAAVPLYSMAYALYYNKAMFKEAGITEPPKTWDELTADGAKISKGGKWGLGAEGSNLSNNIHQVFVLAKQHGGDFFTADGKADFTNDAAVAAVKQYVDMMATNKIIAPGNAEYAKNQSLSDFSKGKTAMVLWQAAATTFKSQGMQDDEWGVAPVPVQSGAPGAGKATNSMVAGINLAVFKNTKNIDGSMKFVKFMTSDAEQKLLCKTYGSIPPVKAAQSDPAFDRPELKVLRETLATSATALPQVSDESQFETSVGTAVKNLFAQAANGKKLSTADVKAELTKAQQQMASQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-09-29" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JUX2</accession>
    <name>A0A2M9JUX2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Helicase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_15880</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000004">
        <property type="protein sequence ID" value="PJN10681.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN10681">
        <property type="protein sequence ID" value="PJN10681"/>
        <property type="gene ID" value="CG723_15880"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0347">Helicase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN10681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="458" mass="48559" checksum="78A8B8D91424F0B6" modified="2018-04-25" version="1">MTAAPHAPGRSGTNGDTPFDPGAEAGRATDGILRDTLHGTARGIVVDSPPGAGKSTLVVRAALELAEAGRPLMVIAQTNAQVDDLVLRLAEKNPELPVGRLHSSDPDPYDKALDDLANVRKSTKAGDLAPLPVVISTAAKWAHVKDITPWQHAIVDEAYQMRSDALLAVAGLFERALFVGDPGQLDPFAIVGAEQWAGLSYDPSASAVTTLLAHNPELPQHRLPVSWRLPASAAPLVSGAFYPYTPFRSGTDHGDRSLGFEVASDGSGPDRVIDEAAESGWGLLELPARHTPRTDPEAVRALAQVVRRLLDRGGATVSERGPDPSPLTTDRIAVGTAHRDQAAAVRSALADLGVTDVTVDTANRLQGREFDVTVVLHPLSGRPDATAFHLETGRLCVLASRHRHACIVVCRAGVPALLDDHPSTEPVQLGVTVKFPDGWEANHAVLARLAEHRVGWMP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JUY7</accession>
    <name>A0A2M9JUY7_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">L-lysine N6-monooxygenase MbtG</fullName>
            <ecNumber evidence="5">1.14.13.59</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Lysine 6-N-hydroxylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Lysine N6-hydroxylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Lysine-N-oxygenase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Mycobactin synthase protein G</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CG723_16025</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CB01635</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>L-lysine + NADPH + O2 = H2O + N(6)-hydroxy-L-lysine + NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:23228"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:32551"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:57820"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.14.13.59"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Siderophore biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the lysine N(6)-hydroxylase/L-ornithine N(5)-oxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.13.59" evidence="5"/>
    <dbReference type="EMBL" id="NNBL01000004">
        <property type="protein sequence ID" value="PJN10705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN10705">
        <property type="protein sequence ID" value="PJN10705"/>
        <property type="gene ID" value="CG723_16025"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00275">
        <property type="reaction ID" value="UER00399"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047091">
        <property type="term" value="F:L-lysine 6-monooxygenase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044249">
        <property type="term" value="P:cellular biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901566">
        <property type="term" value="P:organonitrogen compound biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025700">
        <property type="entry name" value="Lys/Orn_oxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42802">
        <property type="entry name" value="PTHR42802"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13434">
        <property type="entry name" value="K_oxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00016406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00029939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00032493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00032738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PJN10705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="426" mass="48332" checksum="B31C41AA65F025EC" modified="2018-04-25" version="1">MSKLPESRDPLDFIGIGLGPFNLGLAALTEPIAELNGVFLESKPDFEWHSGMFLEGAHLQTPFMSDLVTLADPTSPYSFLNYLKESGRLYSFYIRENFYPLRTEYNDYCRWAAAKLTSIRFGTTVTQVSYDEAAEVYVVSTEGGETYRAPRLVLGTGTPPHIPEPVRGLGGDAIHNSRYLHHKQELQQKDSITLVGSGQSAAEIYYDLLSEIDVHGYRLNWVTRSPRFFPLEYTKLTLEMTSPEYVDYFHALPEETRYRLETQQKNLFKGIDGDLINEIFDLLYQKNLAGPVPTRLLTNSSLQNASYENGTYTLGLRQEEQGKDFELRTDGLILATGYKYETPAFLEPVRDRLNWDSRGRFDLARNYSVDTTGRGVFVQNAGVHTHSITSPDLGMGAYRNAYIIRELLGTEYYPVEKTIAFQEFAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JV09</accession>
    <name>A0A2M9JV09_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Methylcrotonoyl-CoA carboxylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CG723_16060</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000004">
        <property type="protein sequence ID" value="PJN10710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN10710">
        <property type="protein sequence ID" value="PJN10710"/>
        <property type="gene ID" value="CG723_16060"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034733">
        <property type="entry name" value="AcCoA_carboxyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011763">
        <property type="entry name" value="COA_CT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011762">
        <property type="entry name" value="COA_CT_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045190">
        <property type="entry name" value="MCCB/AccD1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22855">
        <property type="entry name" value="PTHR22855"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01039">
        <property type="entry name" value="Carboxyl_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50989">
        <property type="entry name" value="COA_CT_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50980">
        <property type="entry name" value="COA_CT_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CoA carboxyltransferase N-terminal" evidence="2">
        <location>
            <begin position="25"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="domain" description="CoA carboxyltransferase C-terminal" evidence="3">
        <location>
            <begin position="282"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PJN10710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="540" mass="57412" checksum="69179849C5636341" modified="2018-04-25" version="1">MQEAPELTSAADPASEAWKANEAAHEALADELRGKLAAARLGGGERARARHTARGKLLPRDRVDTLLDPGSPFLELAPLAADGMYGDQAPAAGVIAGIGRVSGRACVIVANDATVKGGTYYPMTVKKHLRAQEVALENRLPCVYLVDSGGAFLPMQDEVFPDREHFGRIFYNQARMSGAGIPQIAAVLGSCTAGGAYVPAMSDEAVIVRNQGTIFLGGPPLVKAATGEVVTAEELGGGEVHSRISGVTDHLAEDDAHALRIVRTIVSTLPERGELPWSVTPAIEPKVDPAGLYGAVPVDSRTPYDVREVIARVVDGSRFAEFKAEFGQTLVTGFARIHGHPVGIVANNGILFSESAQKGAHFIELCDQRGIPLVFLQNISGFMVGRDYEAGGIAKHGAKMVTAVASTRVPKLTVVVGGSYGAGNYSMCGRAYSPRFLWMWPNAKISVMGGEQAASVLATVKRDQLEARGEQWPAEDEDAFKAPIRAQYEEQGNAYYATARLWDDGVIDPLETRQVLGLALTACAHAPLPEKSGGFGVFRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JV58</accession>
    <name>A0A2M9JV58_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">LysR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CG723_16140</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CB01635</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LysR transcriptional regulatory family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000004">
        <property type="protein sequence ID" value="PJN10722.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN10722">
        <property type="protein sequence ID" value="PJN10722"/>
        <property type="gene ID" value="CG723_16140"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005119">
        <property type="entry name" value="LysR_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000847">
        <property type="entry name" value="Tscrpt_reg_HTH_LysR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00126">
        <property type="entry name" value="HTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03466">
        <property type="entry name" value="LysR_substrate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50931">
        <property type="entry name" value="HTH_LYSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014935554" evidence="3">
        <location>
            <begin position="22"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="domain" description="HTH lysR-type" evidence="4">
        <location>
            <begin position="2"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="296"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PJN10722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="316" mass="34030" checksum="5802C535AEA27C34" modified="2018-04-25" version="1">MLDLQRLRALHAVSVHGTVGAAAAALGYTPSAVSQQISKLERETRTVLLERHGRGVRLTDEALELARTAQDLMVIVERAETDLEERRGLPAGRLTIAAFASAARGLLPSVLADLAVRHPSLDARLTEVDPHLSVDLVAKGAVDLAVAHDWDIAPLPAPAGVEQAAIGDDLCDLLVPAGHPLAGRHAVRREELGGERWVSQPPGRVCHDWLVRTLRAAGFEPDIRHQAEENPTLTALVAAGLGVALIPRLGRGPLPDGVVAVPLDPMPVRHLYALWRTGASRRPAIAEAVRTLRERWGEITREPDQAGQPDQPDKTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JV70</accession>
    <name>A0A2M9JV70_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Copper-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CG723_16235</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000004">
        <property type="protein sequence ID" value="PJN10738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN10738">
        <property type="protein sequence ID" value="PJN10738"/>
        <property type="gene ID" value="CG723_16235"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00371">
        <property type="entry name" value="HMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017969">
        <property type="entry name" value="Heavy-metal-associated_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006121">
        <property type="entry name" value="HMA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036163">
        <property type="entry name" value="HMA_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00403">
        <property type="entry name" value="HMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55008">
        <property type="entry name" value="SSF55008"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01047">
        <property type="entry name" value="HMA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50846">
        <property type="entry name" value="HMA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HMA" evidence="3">
        <location>
            <begin position="38"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PJN10738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="105" mass="10284" checksum="14E04C9DD7E498B7" modified="2018-04-25" version="1">MSAQTELPQIGTESTGSCCSPSGSCHSDAAGSAEGAVTTVYQVTGMTCGHCEGAVSNEISGLAGVMSVKAAASTGQVTVVSAAPLDEEEVRAAVDEAGYELAGRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JVA0</accession>
    <name>A0A2M9JVA0_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Protein-L-isoaspartate O-methyltransferase</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">L-isoaspartyl protein carboxyl methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="3">Protein L-isoaspartyl methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">Protein-beta-aspartate methyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CG723_16430</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CB01635</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the methyltransferase superfamily. L-isoaspartyl/D-aspartyl protein methyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000004">
        <property type="protein sequence ID" value="PJN10768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN10768">
        <property type="protein sequence ID" value="PJN10768"/>
        <property type="gene ID" value="CG723_16430"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004719">
        <property type="term" value="F:protein-L-isoaspartate (D-aspartate) O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000682">
        <property type="entry name" value="PCMT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11579">
        <property type="entry name" value="PTHR11579"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005369"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00030757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00031323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00031350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PJN10768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="328" mass="36107" checksum="2B15182CC516287A" modified="2018-04-25" version="1">MGAQGTDPEAGAEAARAALVREIAVSGAFDGDPAWREVFEQVPRHVFVPYYYLPAPTGYRRLWREDPDPRQRERWLRGAYADEPLATRVRDGELVSSSSQPSLMARMLIELDVHEGDRVLEIGAGTGYNAALLARRAGDENVTTVDLDPEITETARRHLAAAGFRPAVVTGDGATGCPEHAPYDRIIATCALRAVPSAWPAQCRPGARILAPLATGLILLTVREAGHAEGRFLHTPAYFVPLRGGTQGEEPVQHIGGLPRRVLADELFRFLLSLTAGRLDPHEALALWEREGRPVRERFGITVSGELEWAWLDDPEGPYAWSLRPDRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-06-02" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JVC8</accession>
    <name>A0A2M9JVC8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">NUDIX hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CG723_16635</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CB01635</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the Nudix hydrolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000004">
        <property type="protein sequence ID" value="PJN10802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN10802">
        <property type="protein sequence ID" value="PJN10802"/>
        <property type="gene ID" value="CG723_16635"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020476">
        <property type="entry name" value="Nudix_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020084">
        <property type="entry name" value="NUDIX_hydrolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00502">
        <property type="entry name" value="NUDIXFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="SSF55811"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00893">
        <property type="entry name" value="NUDIX_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="4">
        <location>
            <begin position="4"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003476"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PJN10802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="151" mass="16875" checksum="796A587E2FB4548E" modified="2018-04-25" version="1">MHRELRVAAYAVCVRDGQVLLARWVAGDGTRRWTLPGGGMDHGEDPYDTVIRELDEETGYVVEPGTLLGVHSVLRRYPRKLGAVADFHGLRLVYEGRITGGELRHEVNGSTDMAAWHALDDVPRLARVELVDVGLELWRERPAAGHVFPEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JW30</accession>
    <name>A0A2M9JW30_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="17">PTS lactose transporter subunit IIC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">CG723_08960</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">CB01635</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell inner membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN11090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN11090">
        <property type="protein sequence ID" value="PJN11090"/>
        <property type="gene ID" value="CG723_08960"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022877">
        <property type="term" value="F:protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009401">
        <property type="term" value="P:phosphoenolpyruvate-dependent sugar phosphotransferase system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00211">
        <property type="entry name" value="PTS_IIA_fru"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05569">
        <property type="entry name" value="PTS_IIB_fructose"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016152">
        <property type="entry name" value="PTrfase/Anion_transptr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002178">
        <property type="entry name" value="PTS_EIIA_type-2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036095">
        <property type="entry name" value="PTS_EIIB-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013011">
        <property type="entry name" value="PTS_EIIB_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003501">
        <property type="entry name" value="PTS_EIIB_2/3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003352">
        <property type="entry name" value="PTS_EIIC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013014">
        <property type="entry name" value="PTS_EIIC_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004715">
        <property type="entry name" value="PTS_IIA_fruc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003353">
        <property type="entry name" value="PTS_IIB_fruc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006327">
        <property type="entry name" value="PTS_IIC_fruc"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00359">
        <property type="entry name" value="PTS_EIIA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02378">
        <property type="entry name" value="PTS_EIIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02302">
        <property type="entry name" value="PTS_IIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52794">
        <property type="entry name" value="SSF52794"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55804">
        <property type="entry name" value="SSF55804"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00829">
        <property type="entry name" value="FRU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00848">
        <property type="entry name" value="fruA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01427">
        <property type="entry name" value="PTS_IIC_fructo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51094">
        <property type="entry name" value="PTS_EIIA_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51099">
        <property type="entry name" value="PTS_EIIB_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51104">
        <property type="entry name" value="PTS_EIIC_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="11 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-0598">Phosphotransferase system</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="9 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="318"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="361"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="398"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="440"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="483"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="524"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="563"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="625"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="domain" description="PTS EIIA type-2" evidence="14">
        <location>
            <begin position="3"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="domain" description="PTS EIIB type-2" evidence="15">
        <location>
            <begin position="183"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="domain" description="PTS EIIC type-2" evidence="16">
        <location>
            <begin position="310"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="137"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="651"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="12">
        <location>
            <begin position="154"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="PJN11090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="677" mass="69028" checksum="DDE5C4C943BE9055" modified="2018-04-25" version="1">MSEMITADLVDLDLSADTKEAAARALAERMAARGRVTDLDGFLADVAAREAQMPTGLDGGIGIPHCRSEHVTEPTLAFGRSADGIDFGAPDGPADLIFLIAAPAGADDAHLTILSSLARQLMDEDFKAALRTATDTGATAALIRGDEPEPAPEPEPTPEPTTEMEPTPEPETAPTAPASKFKIVAVTSCPTGIAHTYMAAESLEKAGLEAGDVEVVVETQGSAGFTRLAPEVIAAADGVIFAHDVPVREKDRFAGKPTVDVGVKAGINRPAALIGEVREKAARGETTSGAASATPVDRAGDAGDGYGTKLRKWLMSGVSYMVPFVAAGGLLIALGFAIGGYTINKAPSVAEHFVWTQTDSWAALLFQVGSVAFAFLVPVLAGFIAYGMADRPGLVPGFVGGSIALTINAGFLGGLAAGLIAGGVVMAIQKVHVPPVLRGIMPVVVIPLISSAVVGFLMFLVIGKPIASLQRALTDWLNSLSGANAIILGVVLGLMMCFDLGGPLNKVAYAFAVGGLANPTEGSLKVMAAVMAAGMVPPLAMALATTVRGRLFTRTERENGKAAWVLGASFITEGAIPFAAADPLRVIPASMAGGAVTGALSMAFGCTLRAPHGGIFVVPLIGNPFLYLIAIAAGVCVSTALVVILKGMRKSAPEGGADGAGDATAQKGEEPKIPVAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JW76</accession>
    <name>A0A2M9JW76_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CG723_09275</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN11140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN11140">
        <property type="protein sequence ID" value="PJN11140"/>
        <property type="gene ID" value="CG723_09275"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045773">
        <property type="entry name" value="DUF6226"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19736">
        <property type="entry name" value="DUF6226"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PJN11140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="216" mass="22658" checksum="B32FFBC6E582040A" modified="2018-04-25" version="1">MDLVGLCRAVDEEFAVTGVGTPPWPDPHPGGEVRDEEYSRCLEPAKYLVLAARAEAWTRALSRLGLAEVETVADPAAIWRRAPDVGVSDAVRLHPVRAHAVPLVFGFSAIDKVPGTVLVVGAGDPAVTLEQLPDCGCDACDSGSADLLEVVDEVVAAVVTGTFVHVDAGHGREIVCTGDSWSASNWDASGPPVEEALAAARAGRSPFRVVRGTAWE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JW84</accession>
    <name>A0A2M9JW84_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CG723_08940</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CB01635</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GPN-loop GTPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN11088.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN11088">
        <property type="protein sequence ID" value="PJN11088"/>
        <property type="gene ID" value="CG723_08940"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004130">
        <property type="entry name" value="Gpn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03029">
        <property type="entry name" value="ATP_bind_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PJN11088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="198" mass="21416" checksum="47DD7CC6F2377B37" modified="2018-04-25" version="1">MASVHSDRAAHPAPADFTALKLLIAGGFGVGKTTLVESVSEIRPLRTEEPLTEASRPVDSLEGVATKSTTTVAMDFGRITLRDTLALYLFGTPGQDRFWFVWDELATGCLGAVVLADTRRLADCFPAIDYFESRGIPFIVAVNCFDGIRTHSQDAVARALDLTADTPVLLCDVRDRESGKEVLISLVEHVLALDPTPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JWL9</accession>
    <name>A0A2M9JWL9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="10">ABC transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CG723_10005</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN11259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN11259">
        <property type="protein sequence ID" value="PJN11259"/>
        <property type="gene ID" value="CG723_10005"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="SSF90123"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="46"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="80"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="154"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="179"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="268"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="9">
        <location>
            <begin position="47"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="8">
        <location>
            <begin position="377"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="414"/>
            <end position="421"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PJN11259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="627" mass="67396" checksum="F155FAD364A35834" modified="2018-04-25" version="1">MSMETTAWTQLHSVMNAQQDTRPFAPATLRRIAAFARPHRRRIAQFVVLSVVTALTAVATPVLAGHVVDAIVAGKDEGTVIRLALLIAVIALVEAGLGIVARWLSANLGEGLILDLRTAVFDHVQRMPVAFFTRTRTGALVSRLNNDVIGAQRAFSNTLSGVVGNVVTLLLTLVVMLTLSWQITLLALVLLPVFVVPARRMGTRMARLQREAAAHNAAMGTRMTERFSAPGATLIKLFGRPGDESAEFAARASRVRDIGVRTAMAQSAFITALTLVSALALALVYGLGGYYAIEGTLEAGAVVSLALLLTRLYAPLTSLAGARVEVMSALVSFERVFEVLDLKPLIDEKPDAREVPEGPVAVEFDDVRFGYPSADKVSLASLEEVASLDTRGGAEVLHGISFRAEPGQTVALVGTSGAGKSTVAQLMPRLYDTDEGAVRIGGVDVRDLTAVSLRETLGMVTQDGHLFHDSVRANLLLARPGASEEDLWDVLRRSRLEDLVHSLPDGLDTVVGERGYRLSGGERQRMTIARLLLARQRVVILDEATAHLDNTSEAAVQEALAEALEGRTAVVIAHRLSTIRSADQILVVEDGHIVERGTHETLLAEDGRYAELYRTQFANPTDVVEAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JWN0</accession>
    <name>A0A2M9JWN0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Dipeptide/oligopeptide/nickel ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CG723_09805</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN11228.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN11228">
        <property type="protein sequence ID" value="PJN11228"/>
        <property type="gene ID" value="CG723_09805"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015833">
        <property type="term" value="P:peptide transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013563">
        <property type="entry name" value="Oligopep_ABC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08352">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01727">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="9"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="50"/>
            <end position="57"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PJN11228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="339" mass="37453" checksum="BA3AA3A2F92C68D8" modified="2018-04-25" version="1">MPAPAEPVLEARDVVKRFPLHGPGGHGKEVHAVEPTSLALHAGRITALVGESGSGKSTLARMLALAYPPTEGEIRLDGAPVKQARTARGKRAYYRQVQMIFQDPFSSLSPVHRLRYILSRPLQLHGHAAGRAELERQILDLLNRVNLTPADQFIDKFPHELSGGQRQRVAIARALAARPKVLLGDEPVSMLDVSIRLDILNLLGRLRDDEGLAILYITHDIAGARYFADEIKVLYAGQLVESGPADTVVEQPRHPYTRLLLESAPDPDRDGGLLDEPEVVDDEETLGEPPSLVDPPAGCRFHPRCPLAKPVCATAFPPRTHFDDGQWVHCWSYDEENYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JWN2</accession>
    <name>A0A2M9JWN2_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 11">Diacylglycerol O-acyltransferase</fullName>
            <ecNumber evidence="5 11">2.3.1.20</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CG723_10140</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">CB01635</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>a 1,2-diacyl-sn-glycerol + an acyl-CoA = a triacyl-sn-glycerol + CoA</text>
            <dbReference type="Rhea" id="RHEA:10868"/>
            <dbReference type="ChEBI" id="CHEBI:17815"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:58342"/>
            <dbReference type="ChEBI" id="CHEBI:64615"/>
            <dbReference type="EC" id="2.3.1.20"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 11">Glycerolipid metabolism; triacylglycerol biosynthesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Lipid metabolism.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 11">Belongs to the long-chain O-acyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.20" evidence="5 11"/>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN11284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN11284">
        <property type="protein sequence ID" value="PJN11284"/>
        <property type="gene ID" value="CG723_10140"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00282"/>
    <dbReference type="UniPathway" id="UPA00391"/>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004144">
        <property type="term" value="F:diacylglycerol O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006071">
        <property type="term" value="P:glycerol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019432">
        <property type="term" value="P:triglyceride biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014292">
        <property type="entry name" value="Acyl_transf_WS/DGAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045034">
        <property type="entry name" value="O-acyltransferase_WSD1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009721">
        <property type="entry name" value="O-acyltransferase_WSD1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004255">
        <property type="entry name" value="O-acyltransferase_WSD1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31650">
        <property type="entry name" value="PTHR31650"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03007">
        <property type="entry name" value="WES_acyltransf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06974">
        <property type="entry name" value="WS_DGAT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02946">
        <property type="entry name" value="acyl_WS_DGAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 11 14" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="8 11" id="KW-0319">Glycerol metabolism</keyword>
    <keyword evidence="6 11" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="9 11" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 11 14" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="WES_acyltransf" evidence="12">
        <location>
            <begin position="18"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="domain" description="WS_DGAT_C" evidence="13">
        <location>
            <begin position="312"/>
            <end position="457"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU361241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF03007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF06974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="PJN11284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="468" mass="49387" checksum="228C3B69412DF379" modified="2018-04-25" version="1">MNSQQSQHSRPAPSPDLLAPLDLAFWNIESAEHPMHLGALGVFAAGSPGDVQHAVELLAARAPAVPGLRMRIQGVRIPVGGAARVPVPDFDPLDHVRLGEPTADFHAAAGALMERPLDRARPPWEAHVLPGADGTSFAVLFKFHHALADGLRALTLAAGVMDPMDLPVSRTAPAVAAPRGFRLPFPGMRDLRLGDLDPRKLPGLLREGASSAVTALDIGTSVVRATWDVHTSPAFSSNATGTRSTEGVVLELDDVHRVRKTVGGTVNDVLIAVVAGALRRWLDERGNGSEGVRPRALIPVSRRRPRTAHPQGNRLSGYLVKLPVDERDPLARLRAVRTAMDHNKDAGPQRGAGAVALLADHVPPLGHMIGGPVVAQAARLLFDILVTSVPLPSLGLRLGGCPLTEVYPLAPLAQGQSLAVAVSTYRGRVHYGLVADAAAVPDLDVLATGIREELAALVRVCETVRGTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JWW2</accession>
    <name>A0A2M9JWW2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CG723_10745</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN11391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN11391">
        <property type="protein sequence ID" value="PJN11391"/>
        <property type="gene ID" value="CG723_10745"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="2"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="35"/>
            <end position="42"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PJN11391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="221" mass="23627" checksum="723DFA4D4E281542" modified="2018-04-25" version="1">MLELISVTAGYERGNPVVRNAGLAIAPGEAVGLLGPSGCGKSTLARVAALLHRPDSGRVVIDGEPARGWRHRAPREQRTAFGVVFQQPRMSADPRLRLAALIAEPLRATGLKPDDRVGELAATVGLGADLLSRRPHEVSDGQLQRACLARALALRPRWLICDEMTAMFDASTTAALVGVVENYRAETGAGLLAVGHDRRLLERWCGRTVEWDALGSAGEGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JXC4</accession>
    <name>A0A2M9JXC4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Sugar kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CG723_11610</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN11540.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN11540">
        <property type="protein sequence ID" value="PJN11540"/>
        <property type="gene ID" value="CG723_11610"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000600">
        <property type="entry name" value="ROK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18964">
        <property type="entry name" value="PTHR18964"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00480">
        <property type="entry name" value="ROK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01125">
        <property type="entry name" value="ROK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PJN11540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="309" mass="29765" checksum="42650670B096E63E" modified="2018-04-25" version="1">MTVTGPAIGLDLGGTKIAAALVAPDGTVLARHTRPTPAADGPGAVLDALADAARSVDGGTGPGALGVAAAGVIDPVTGRVTSATHSIRGWAGTALAAGLAVRTGLPVACDNDVRATAAPELAAAGAGASLVYAAIGTGVGGAVAVGGRMVHGTAGIAGHLGHVPSPEAAGLPCTCGGTGHLEAVASGPGIAALYGRLTGRPLERLETVAERAASGEEPAVRAIVTGAVAAGRVLGGLANTLGPDRVVVGGGVPHIGPLYWDALTEAFASELMPPLARLRPSRPLFGADAAVIGAARLPSQVPLHAPPQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JXX0</accession>
    <name>A0A2M9JXX0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_12670</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN11711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN11711">
        <property type="protein sequence ID" value="PJN11711"/>
        <property type="gene ID" value="CG723_12670"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="41"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="82"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="124"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN11711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="167" mass="17297" checksum="AE128E9E0DCB7863" modified="2018-04-25" version="1">MNAFLLAALALVDAVFAGFRAYTGRDGRIRKSKRALLAARRGLAVGAPALLLSAALAVALLVAAADRDARYAELDAAAQRMLLCYAPYAVIVALSLGCYLWGPFRAGTLAVVVGLGPLTLMRPLVVLAGAVAAAWGSLPAASVAAVAAVGVLLVEPFVHRRWYAEPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JY06</accession>
    <name>A0A2M9JY06_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">RNA polymerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CG723_12855</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CB01635</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN11742.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN11742">
        <property type="protein sequence ID" value="PJN11742"/>
        <property type="gene ID" value="CG723_12855"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050896">
        <property type="term" value="P:response to stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039425">
        <property type="entry name" value="RNA_pol_sigma-70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013249">
        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43133">
        <property type="entry name" value="PTHR43133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08281">
        <property type="entry name" value="Sigma70_r4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="5">
        <location>
            <begin position="20"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4_2" evidence="6">
        <location>
            <begin position="121"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PJN11742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="178" mass="19677" checksum="C901A8A69D78B61D" modified="2018-04-25" version="1">MEDSLRARIRAGDADAFAELFDDTSPEVHRMALRATGDWAQAEDVVSLTFLEIWRLRQTVRREDAPLRPFVLGVGLNVLRNQSRSARRHRAALARLPACEHLPDFADEVVDRIADAEQVAAARTALDALNRAERDVVLLCGWSELNSEAAAEILGVAPGTVRSRLSRARARLRASVDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JY89</accession>
    <name>A0A2M9JY89_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CG723_13460</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CB01635</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) family. Azg-like subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN11840.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN11840">
        <property type="protein sequence ID" value="PJN11840"/>
        <property type="gene ID" value="CG723_13460"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015205">
        <property type="term" value="F:nucleobase transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904823">
        <property type="term" value="P:purine nucleobase transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045018">
        <property type="entry name" value="Azg-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006043">
        <property type="entry name" value="NCS2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43337">
        <property type="entry name" value="PTHR43337"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00860">
        <property type="entry name" value="Xan_ur_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="40"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="65"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="92"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="124"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="152"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="189"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="215"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="263"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="305"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="344"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="398"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="436"/>
            <end position="453"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PJN11840.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="454" mass="46570" checksum="7D5ECE5DEF9F8815" modified="2018-04-25" version="1">MPPTAPTTGEQTAVTTEPPASLTERLFSVRGRGSTHRTEIVAGASMFMAAAYAVVVVPGQLAGAGVPHGAATTAVIIAIALATLAMGLIANLPFVVAPGLGGVALVAFTIVGQDHVPWDTALGMVFWSGVAFLVLTLLGIRDLVTRLMPMHLKYAISGGLGLYIALIGFRDADLVVGNADKAALAVGDLSKPAGLLALAGLLLLTALASRKVPGAFLLTIAAVTIAGIPLGVTEVPDSLFSAPDSPGPLLFHIDILGALKPEYFPYIFAFFVSEFFSMTGTLLAVAGRAGLLDKDGNIPGSRRPFLVDSVSVMGGAAVGAPSMTAYLESSAGADSGGRTGLASVWAACGFGLLLLVTPFATLIPSAATAPVLMYIGLNMLGALKNVDFKDPTHAVPAALTVATTLFFGNFGTGIATGLAAHVLVKTVSGRIREVAWPLWIVMIPLGYYFYTLVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JYC1</accession>
    <name>A0A2M9JYC1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycosyl transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_13625</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN11864.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN11864">
        <property type="protein sequence ID" value="PJN11864"/>
        <property type="gene ID" value="CG723_13625"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016758">
        <property type="term" value="F:hexosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008194">
        <property type="term" value="F:UDP-glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030259">
        <property type="term" value="P:lipid glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033072">
        <property type="term" value="P:vancomycin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="CDD" id="cd03784">
        <property type="entry name" value="GT1_Gtf-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004276">
        <property type="entry name" value="GlycoTrans_28_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002213">
        <property type="entry name" value="UDP_glucos_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03033">
        <property type="entry name" value="Glyco_transf_28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00201">
        <property type="entry name" value="UDPGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_transf_28" evidence="1">
        <location>
            <begin position="5"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN11864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="428" mass="45376" checksum="8690CCE9B5398CD1" modified="2018-04-25" version="1">MRIQVITVGSTGSVAPYTGLAHRLLADGHTVEIVTHTKFAPMVACCGLRMEPLEADPFEALIGAHSRATGGAKGAVHPSSAPHSPQLQAVKSLRSLVRSTEQAMLSLVDAILAAVDPKADLILLSTIAAPIGAAIARYHGIPTMGVFLQPDVPTAEFAPCTMAWHSPGRTNRLRGHAANALFDTLYRTAHRAVHARLGVDHRSAHRLRNVRERNQWPIWHGYSPWVVPRPADWRQGLHVAGYWWPHECPNWQPPTLVRDFLAAGPPPVLIGFGSMMPGDPEELGQIAAQALRRAGLRGVVQSGWAGLSVVDDDVITVGEIPHSWLMPQTAAVVHHAGAGTTAAGLRAGVPAVPVPVMTDQPWWAARLVQLGVSAEAVPCTELTAARLADALTRATQDRALSRNAAAAAVRLAKEDGAGAVARAVAALG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JYJ5</accession>
    <name>A0A2M9JYJ5_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">FCD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CG723_14145</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN11953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN11953">
        <property type="protein sequence ID" value="PJN11953"/>
        <property type="gene ID" value="CG723_14145"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.530">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011711">
        <property type="entry name" value="GntR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008920">
        <property type="entry name" value="TF_FadR/GntR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07729">
        <property type="entry name" value="FCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48008">
        <property type="entry name" value="SSF48008"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="FCD" evidence="5">
        <location>
            <begin position="20"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF07729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PJN11953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="77" mass="8453" checksum="7CEC6D329D5F21A6" modified="2018-04-25" version="1">MRAAMRGTATQPRIVKAAESRNESLRQPGRPAQSLEQHQLVADAVRAGSPEDAARAMHTHVDNVGKVKLLDWRPEGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-05-25" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JYX3</accession>
    <name>A0A2M9JYX3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Alcohol dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CG723_14920</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CB01635</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN12082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN12082">
        <property type="protein sequence ID" value="PJN12082"/>
        <property type="gene ID" value="CG723_14920"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="PKS_ER"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="PKS_ER" evidence="3">
        <location>
            <begin position="14"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PJN12082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="341" mass="35264" checksum="3F3602FC58B05697" modified="2018-04-25" version="1">MTTYRAAQVITPDGRFEIVEREVPRPGPMHVRLAVEACGICHSDDGFVSGAMPGVRFPLVPGHEVAGRIEELGEGAQSNNWNVGDRVTVGWFGGSCGHCVPCRQGDYMVCDSLKIPGLAYDGGYAESMIAPIDALARIPDALSATDAGPMACAGVTTYNGLRRSSARAGDLVAVLGIGGLGHLAVQYAVAMGFETVAIARGSEKAGTAKDLGAHHYVDSTGATSVAEALQSLGGAKVVLATAGSSEAIAATVDGLTHRGELVVIGVSPDPIGISPLQLILRGRILRGHPAGTAQDVQDTMAFSALHGIRPMVETMPLSEADGAYRKMLSGSARFRMVLTSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JZF1</accession>
    <name>A0A2M9JZF1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">TetR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_14225</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN12228.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN12228">
        <property type="protein sequence ID" value="PJN12228"/>
        <property type="gene ID" value="CG723_14225"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="9"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="32"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN12228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="203" mass="23229" checksum="EF259CD494E27C4C" modified="2018-04-25" version="1">MTPRSPRGVRTRNALITAAREVFERDGYLDARITDISKAAHVASGSFYTYFNSKEEIFQALVAQVQEEMLHPHLRERTGITDTRQLIDASNREYLRAYKKNARLMALFEQVAQVDEKFMALRIERGNAFARRNAKLIRTLQENGEADTSLDPLVTAHALSVMVSRMAYMVFVLGQRIPFERLVTTLNKLWENGLQLTASEPEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JZN8</accession>
    <name>A0A2M9JZN8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_04685</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000002">
        <property type="protein sequence ID" value="PJN12353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN12353">
        <property type="protein sequence ID" value="PJN12353"/>
        <property type="gene ID" value="CG723_04685"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014935558" evidence="1">
        <location>
            <begin position="41"/>
            <end position="459"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN12353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="459" mass="50305" checksum="44813584023215AF" modified="2018-04-25" version="1">MTATPPMRPYAPSMRPRAALRDLLGLVLLPLPLVAVAVAAAPAAFAGGGTRRWFGRGEGQRAEAQAAKDAAAAAFYELDTAQRDLRISIETITAVDDSPAARRTVSDFEALGRRIDEASLQYITAVDAHDLDRDDLEASVASRARAELSRAKDELTKVKLDLDRFSQGLGPLLGKAETQLARLAPAVERARQALLAASNSLDAVRGAGLKADDLAARLAALGPELTRLNQGAGRHGVPETLERAERVARDAEAVRAEARRLPERAAEIDRRLVSLRTRAQALTTRAGQVEPVLSELRRRFSARCWQDLQHVPERAAENVRQAERKLAEARTARDEQRWPDATSLLSTVRALLNTTDEDVSAASDRLHRLNAVAKDPQQEIDRTRFAIRDAQRLAMSGRSTPEPRHARPLDDSVARLDRAVAALDGRHPDYWHFLTETEAVRQTVARVVAQIREDRGAPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-09-29" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JZU2</accession>
    <name>A0A2M9JZU2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_04965</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000002">
        <property type="protein sequence ID" value="PJN12399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN12399">
        <property type="protein sequence ID" value="PJN12399"/>
        <property type="gene ID" value="CG723_04965"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lactamase_B" evidence="1">
        <location>
            <begin position="25"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN12399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="345" mass="37425" checksum="D9D64EE417EC7DA5" modified="2018-04-25" version="1">MTQVTDHGGGVWSLRVPIPDNPLGFTLVHLLDTDRGPVLIDTGWDDPESWDALTGGLAACGTSVGEVTGVLITHHHPDHHGLSAKVREASGAWIAMHEADVSVVRRTRENPPERWYAFMAAKLAAAGAPEEHMAPLIAARDSGRARSLPGLAPALPDRTITPGDLLDLPGRRLRAIWTPGHTPGHVCLHLEEDHPAGLAGNGRLFSGDHLLPGITPHIGLYEDPDDATVTDPLGDYLDSLERVGRLAPAEVLPAHQHTFTDAPTRVRELLDHHEERLTGLLTLLATPLTPWQLAERMEWNRPWEQIPYGSRTIAVSEAEAHLRRLVKLGRAEAVAGSDPVTYAPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K021</accession>
    <name>A0A2M9K021_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CG723_04710</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000002">
        <property type="protein sequence ID" value="PJN12357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN12357">
        <property type="protein sequence ID" value="PJN12357"/>
        <property type="gene ID" value="CG723_04710"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PJN12357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="121" mass="13313" checksum="A90012B5B76BFE3F" modified="2018-04-25" version="1">MIPGMGYELHMTRASDWLDSEERPISLRDWLEFAHNSAALRQEGHLDLHSVGRQPVFTWGSLDSVAVGLHWCEGRVILSGAHAPGVDLVGLADLAAELSAKLIGDEGEQYPRSVRRGNEEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K0F6</accession>
    <name>A0A2M9K0F6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_06175</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000002">
        <property type="protein sequence ID" value="PJN12615.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN12615">
        <property type="protein sequence ID" value="PJN12615"/>
        <property type="gene ID" value="CG723_06175"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021401">
        <property type="entry name" value="DUF3040"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11239">
        <property type="entry name" value="DUF3040"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="42"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="65"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="90"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="116"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN12615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="136" mass="15131" checksum="065E4A03AA5887CB" modified="2018-04-25" version="1">MPLSEHEQRMLEQMERALYAEDPKFATALEGSGLRTYTRRRVYQAVAGFLVGIALLMAGMVAQQIWISVVGFLVMLGCAVLAVTGWRKAPKPGEQPAAGAAPGAPPAARRQGKQRRSMMNRIEQRWQRRRDEQGGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K0H4</accession>
    <name>A0A2M9K0H4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DUF1059 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CG723_06290</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000002">
        <property type="protein sequence ID" value="PJN12635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN12635">
        <property type="protein sequence ID" value="PJN12635"/>
        <property type="gene ID" value="CG723_06290"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009409">
        <property type="entry name" value="DUF1059"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06348">
        <property type="entry name" value="DUF1059"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PJN12635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="63" mass="7010" checksum="F1EBA449492C8311" modified="2018-04-25" version="1">MRKVVDCRDVPSETNCTLAITGEEDEVVRAAAEHSVSVHGHTDTPELRNMIRSNLKDEIPQHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K0M1</accession>
    <name>A0A2M9K0M1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_06435</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000002">
        <property type="protein sequence ID" value="PJN12659.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN12659">
        <property type="protein sequence ID" value="PJN12659"/>
        <property type="gene ID" value="CG723_06435"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001845">
        <property type="entry name" value="HTH_ArsR_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="SMART" id="SM00418">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH arsR-type" evidence="1">
        <location>
            <begin position="13"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN12659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="195" mass="21721" checksum="0F5A413A4EFFB190" modified="2018-04-25" version="1">MTDKQTRRITDLGTLKALAHPLRSQLYRALVVARTATASQLAEQVDGAVSLVSYHLRKLADAGLIEETPGAQRDGRERWWRPASEGVSIHEADFGDAPEKAAAHQAATRLFYEQRSELYRHYLDERTTWAPEWRAASSDSEALMPLTAAELTELTGELLTVIRKYDEQGRAAQAAGDTEGRENVALHVYGFPFRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K148</accession>
    <name>A0A2M9K148_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Sugar ABC transporter substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_07500</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000002">
        <property type="protein sequence ID" value="PJN12848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN12848">
        <property type="protein sequence ID" value="PJN12848"/>
        <property type="gene ID" value="CG723_07500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006059">
        <property type="entry name" value="SBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01547">
        <property type="entry name" value="SBP_bac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014948610" evidence="1">
        <location>
            <begin position="34"/>
            <end position="456"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN12848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="456" mass="49641" checksum="87DC1FCD93B8CC6A" modified="2018-04-25" version="1">MRTQSRRRPRALCAAAAAGTLLAPLLSGCWAGAGGTGSGGDSINVLMVNNPQMTELQKLTAAHFTKETGIKVNFTVLPENDVRDKISQDFANQAGQYDVATLSNYEIPIYARNGWLHELGSYARKDTAYDERDILKPMRESLTGDDGKLYGQPFYGESSFLMYRKDVFAKKGLRMPAHPTWRQVADLAAKADGAEPGMKGICLRGLPGWGELMAPLTTVVNTFGGTWFDKNWKAQLTSPGFEKATRFYVDLVRKHGESGAAQSGYAECLNNLTQGKTAMWYDATAAAGSLESAKSPVKGKIGYVPAPVERTESSGWLYTWAWGVQNASRNPDKAWKFVSWASGKGYENLVGKEIGWSNVPAGKRASTYTNPEYRKEAAAFQDVTRAAIEGARPRDPGVQPRPAPGIQFVGIPEFTDLGTKVSQEISAAIAGRQSVDTALNKSQKLADEIAKEYEGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K174</accession>
    <name>A0A2M9K174_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Bifunctional cobalt-precorrin-7 (C(5))-methyltransferase/cobalt-precorrin-6B (C(15))-methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CG723_07685</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CB01635</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; adenosylcobalamin biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the precorrin methyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000002">
        <property type="protein sequence ID" value="PJN12882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN12882">
        <property type="protein sequence ID" value="PJN12882"/>
        <property type="gene ID" value="CG723_07685"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00148"/>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008276">
        <property type="term" value="F:protein methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009236">
        <property type="term" value="P:cobalamin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd11644">
        <property type="entry name" value="Precorrin-6Y-MT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.950.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1010.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000878">
        <property type="entry name" value="4pyrrol_Mease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035996">
        <property type="entry name" value="4pyrrol_Methylase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014777">
        <property type="entry name" value="4pyrrole_Mease_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014776">
        <property type="entry name" value="4pyrrole_Mease_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012818">
        <property type="entry name" value="CbiE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006365">
        <property type="entry name" value="Cbl_synth_CobL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014008">
        <property type="entry name" value="Cbl_synth_MTase_CbiT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00590">
        <property type="entry name" value="TP_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036428">
        <property type="entry name" value="CobL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53790">
        <property type="entry name" value="SSF53790"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02467">
        <property type="entry name" value="CbiE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02469">
        <property type="entry name" value="CbiT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0169">Cobalamin biosynthesis</keyword>
    <keyword evidence="4 8" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="TP_methylase" evidence="7">
        <location>
            <begin position="18"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PJN12882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="425" mass="43543" checksum="F9534AEDAFDF2017" modified="2018-04-25" version="1">MITVFGTGTGAPLSPDPALSSAALVVGGRRHLDAAGALLAPGAERVVLGPLAPALDAVERYIEKGQGVAVLASGDPGFFGIVRALAERFGSAALDVRPGVSSVATAFARVGLPWDDAAVVSAHGRDLRTAVNVCRAYPKAAVLTGPGAGPAELGAELAHRGADRVLVVASRLGDPEHESLERVTPSEAAARDWGDAVSVVLCLDEKRVLAPVRTLAGPGRPPSRWALDEGEFEHRDSMITKFEVRALALARLGPRPGDLVWDIGAGSGSVAVECARFGAAAVAVEKTVDGVARIRDNAAAHGVDVRVVHGAAPTVLSDLSDPDAVFIGGGGRELTAIVTACARRTRRSVVVAVAAVDRVGAVRDALGAAGFVTDGVLLQSSRLAPLPGDVSRLAAANPVFLVWGVRPDADAQSATSVDFLERRSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K187</accession>
    <name>A0A2M9K187_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cobyric acid synthase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">cobQ</name>
        <name evidence="7" type="ORF">CG723_07725</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CB01635</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 4">Cofactor biosynthesis; adenosylcobalamin biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the CobB/CobQ family. CobQ subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000002">
        <property type="protein sequence ID" value="PJN12888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN12888">
        <property type="protein sequence ID" value="PJN12888"/>
        <property type="gene ID" value="CG723_07725"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00148"/>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015420">
        <property type="term" value="F:ABC-type vitamin B12 transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009236">
        <property type="term" value="P:cobalamin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01750">
        <property type="entry name" value="GATase1_CobQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00028">
        <property type="entry name" value="CobQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002586">
        <property type="entry name" value="CobQ/CobB/MinD/ParA_Nub-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033949">
        <property type="entry name" value="CobQ_GATase1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004459">
        <property type="entry name" value="CobQ_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011698">
        <property type="entry name" value="GATase_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21343:SF1">
        <property type="entry name" value="PTHR21343:SF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01656">
        <property type="entry name" value="CbiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07685">
        <property type="entry name" value="GATase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00313">
        <property type="entry name" value="cobQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0169">Cobalamin biosynthesis</keyword>
    <keyword evidence="3 4" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CbiA" evidence="5">
        <location>
            <begin position="6"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="domain" description="GATase_3" evidence="6">
        <location>
            <begin position="263"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="4">
        <location>
            <position position="342"/>
        </location>
    </feature>
    <feature type="active site" evidence="4">
        <location>
            <position position="426"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF07685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PJN12888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="503" mass="53274" checksum="BC0E1E899A172735" modified="2018-04-25" version="1">MSGGGLLVAGTTSDAGKSVVTAGICRWLVRQGVKVAPFKGQNMSLNSFVTREGAEIGRAQAMQAQAARVEPSALMNPVLLKPGSDRSSQVVLMGKPVGELSARGYHGGRQAALLDTVVGCLEELRGSYDAVICEGAGSPAEINLRRTDIVNMGIARAARLPVLVVGDIDRGGVFASFFGTTALLAPEDQELLAGYLVNKFRGDVSLLEPGLDMLKDLTGRPTYGVLPFQHGLGIDEEDGLRVSLRGSVRESQTAAPVGEDVLRVAVCAVPLMSNFTDVDALAAEPGVVVRFVDRAEELVDADLVVVPGTRGTVKALQWLRERGLADALARRAAEGRPVLGICGGFQVLGERIEDDVESRLGAVDGLGLLPVRVRFEREKTLARPVGEALGERVEGYEIHHGVAEVTGGEAFLDGCRVGSVWGTHWHGSLEADGFRRAFLREVAAAAGRRFVPAPDTSFGALREEQLDRLGDLIEEHADTDALWRLIESGAPSGLPFIPPGAPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K188</accession>
    <name>A0A2M9K188_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF6286 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_07810</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000002">
        <property type="protein sequence ID" value="PJN12903.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN12903">
        <property type="protein sequence ID" value="PJN12903"/>
        <property type="gene ID" value="CG723_07810"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046253">
        <property type="entry name" value="DUF6286"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19803">
        <property type="entry name" value="DUF6286"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="53"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="99"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6286" evidence="2">
        <location>
            <begin position="110"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF19803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN12903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="220" mass="23470" checksum="214A3F4A3526055D" modified="2018-04-25" version="1">MSEPTQPLPVVERGQGELDQFGQSGSAATYKALPTPEGGHGNGRFWSPRRIPAALVAVVLLGASGVLLYDIAAVRAGHSAMHWRRALARELAERPLDNVWVLVGAGVAAALGLWLIVLAATPGLRAVLPMRRTHTDVRAGLHRDAAAMVLRDRAMEVAGVQSVRVRMKRSKVEVRALSHFRQLDDVRADLDTVIGEAVKGLGLTSTPGLSVHVARPGKKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K1J0</accession>
    <name>A0A2M9K1J0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_06340</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000002">
        <property type="protein sequence ID" value="PJN13003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN13003">
        <property type="protein sequence ID" value="PJN13003"/>
        <property type="gene ID" value="CG723_06340"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="138"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="164"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN13003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="229" mass="23727" checksum="44F6BBD24E59C578" modified="2018-04-25" version="1">MDDISGTQLRAVRAALFTALVVTLSAASHVLLSRVPLPVVTVAATAFAVFVLAYTLAGRERSFGRIAALLVPLELAADTVFTTGQHVCYGAAGGPVAGPLRAVGLDVLCGGGVGAPLARMTGGHTDKAAALLAHTDPAAAWLLLGAHVAVGLLAAAWLRRGEQALAQLLRAVAGFTFRPLLIAFAAVRAHLEPVRRLPRRPARRVRAARTQLWAHSVGRRGPPCVALAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-09-29" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K1K9</accession>
    <name>A0A2M9K1K9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Glycosyl hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CG723_06765</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CB01635</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 35 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000002">
        <property type="protein sequence ID" value="PJN13013.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN13013">
        <property type="protein sequence ID" value="PJN13013"/>
        <property type="gene ID" value="CG723_06765"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004565">
        <property type="term" value="F:beta-galactosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026283">
        <property type="entry name" value="B-gal_1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031330">
        <property type="entry name" value="Gly_Hdrlase_35_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019801">
        <property type="entry name" value="Glyco_hydro_35_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001944">
        <property type="entry name" value="Glycoside_Hdrlase_35"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23421">
        <property type="entry name" value="PTHR23421"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01301">
        <property type="entry name" value="Glyco_hydro_35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006336">
        <property type="entry name" value="B-gal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00742">
        <property type="entry name" value="GLHYDRLASE35"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="SSF49785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01182">
        <property type="entry name" value="GLYCOSYL_HYDROL_F35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glyco_hydro_35" evidence="5">
        <location>
            <begin position="11"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="4">
        <location>
            <position position="156"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="4">
        <location>
            <position position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009809"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR006336-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01301"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PJN13013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="581" mass="63400" checksum="AF9C626FA1A1157A" modified="2018-04-25" version="1">MAGFRVGEDDFEVDGRPVRLLSGALHYFRVHEEQWGHRLAMLRAMGLNCVETYVPWNLHEPRPGELRDVGALGRFLDAVREAGLWAIVRPGPYICAEWENGGLPHWLTGPLGSRVRTRDGEFLAAVDRWFAALLPQVVERQFDRGGPVIMVQVENEYGSYGSDQVYLAHLADGLRGLGVTVPLFTSDGPDDHMLTGGSVPGVLATANFGSNARGGFETLRRHRPKGPLMCMEFWCGWFDHWGADHVVRDAQDAAAALREILECGASVNLYMAHGGTSFGGWAGANRAGQLHEGLLQPDVTSYDYDAPVDEHGRPTEKFWRFREVLAEYADEPLPDVPEQPAALASTVTAELTSYAPLDAVLDGLGSAEGEYAVPPTFEELDVDRGLVRYSVDVPGPRRVYPLRVAGLRDRAVVCVDGVRAGVLTEDEPVLAEPVAGPARIELWVESLGRVNYGPRTGESKGITGGVLHERQYLHGVRARALRLDAFDDADAVRGLAPVDGPPGAAGLYRGTFEVSGAGDAELELPGWTRGFVWVNGFNLGRYWSVGPQHSLYVPGPVLREGRNEVWVLETEAAGEPRVTLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K1S0</accession>
    <name>A0A2M9K1S0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">4-carboxymuconolactone decarboxylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_07040</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000002">
        <property type="protein sequence ID" value="PJN13020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN13020">
        <property type="protein sequence ID" value="PJN13020"/>
        <property type="gene ID" value="CG723_07040"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051920">
        <property type="term" value="F:peroxiredoxin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029032">
        <property type="entry name" value="AhpD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004675">
        <property type="entry name" value="AhpD_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003779">
        <property type="entry name" value="CMD-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02627">
        <property type="entry name" value="CMD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69118">
        <property type="entry name" value="SSF69118"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00778">
        <property type="entry name" value="ahpD_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CMD" evidence="1">
        <location>
            <begin position="28"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02627"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN13020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="164" mass="17916" checksum="645B37EF326BA643" modified="2018-04-25" version="1">MTTNTITAANTHSHSAGRIDFAKAAPKVFRSLIGFDAAAREGLDPALVELIQIRASHLNHCAYCLHMHTNDARKAGESEDRLHMVAVWREARHFFSARERAALALTEAVTLVADGGVPDDVYAEAAAQFDEQELAHVLSLILTINTWNRIALSTAKVAGTDERK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K238</accession>
    <name>A0A2M9K238_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Deoxyuridine 5'-triphosphate nucleotidohydrolase</fullName>
            <shortName evidence="4">dUTPase</shortName>
            <ecNumber evidence="4">3.6.1.23</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">dUTP pyrophosphatase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">dut</name>
        <name evidence="7" type="ORF">CG723_00620</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CB01635</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 4">
            <text>dUTP + H2O = diphosphate + dUMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10248"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61555"/>
            <dbReference type="ChEBI" id="CHEBI:246422"/>
            <dbReference type="EC" id="3.6.1.23"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">Pyrimidine metabolism; dUMP biosynthesis; dUMP from dCTP (dUTP route): step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the dUTPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.23" evidence="4"/>
    <dbReference type="EMBL" id="NNBL01000001">
        <property type="protein sequence ID" value="PJN13140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN13140">
        <property type="protein sequence ID" value="PJN13140"/>
        <property type="gene ID" value="CG723_00620"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00610">
        <property type="reaction ID" value="UER00666"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004170">
        <property type="term" value="F:dUTP diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006226">
        <property type="term" value="P:dUMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046081">
        <property type="term" value="P:dUTP catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07557">
        <property type="entry name" value="trimeric_dUTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00116">
        <property type="entry name" value="dUTPase_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008181">
        <property type="entry name" value="dUTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029054">
        <property type="entry name" value="dUTPase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036157">
        <property type="entry name" value="dUTPase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033704">
        <property type="entry name" value="dUTPase_trimeric"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11241">
        <property type="entry name" value="PTHR11241"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00692">
        <property type="entry name" value="dUTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51283">
        <property type="entry name" value="SSF51283"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00576">
        <property type="entry name" value="dut"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 4" id="KW-0546">Nucleotide metabolism</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="dUTPase" evidence="6">
        <location>
            <begin position="18"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="4">
        <location>
            <begin position="67"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="4">
        <location>
            <begin position="84"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="138"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="80"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PJN13140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="175" mass="18391" checksum="505CC956A972ED62" modified="2018-04-25" version="1">MTRAPLDVLIRRVDPDVPLPSYEHPGDAGADLRTTEACELAPGERAVLPTGVSIALPEGYAAFVHPRSGLAARCGVALVNAPGTVDAGYRGEIKVIVVNLDPRDSVRFERFDRIAQLVVQQVEKVRFQEVAELPDSARAEGGFGSTGGHAAVGPGPGGHQGGNRYASVVSDREGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K265</accession>
    <name>A0A2M9K265_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA topoisomerase (ATP-hydrolyzing)</fullName>
            <ecNumber evidence="3">5.6.2.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CG723_00500</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CB01635</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP-dependent breakage, passage and rejoining of double-stranded DNA.</text>
            <dbReference type="EC" id="5.6.2.2"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the type II topoisomerase GyrA/ParC subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.2" evidence="3"/>
    <dbReference type="EMBL" id="NNBL01000001">
        <property type="protein sequence ID" value="PJN13117.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN13117">
        <property type="protein sequence ID" value="PJN13117"/>
        <property type="gene ID" value="CG723_00500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034335">
        <property type="term" value="F:DNA negative supercoiling activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006265">
        <property type="term" value="P:DNA topological change"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00187">
        <property type="entry name" value="TOP4c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.268.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.199.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006691">
        <property type="entry name" value="GyrA/parC_rep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035516">
        <property type="entry name" value="Gyrase/topoIV_suA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013760">
        <property type="entry name" value="Topo_IIA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013758">
        <property type="entry name" value="Topo_IIA_A/C_ab"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013757">
        <property type="entry name" value="Topo_IIA_A_a_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002205">
        <property type="entry name" value="Topo_IIA_dom_A"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03989">
        <property type="entry name" value="DNA_gyraseA_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00521">
        <property type="entry name" value="DNA_topoisoIV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00434">
        <property type="entry name" value="TOP4c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101904">
        <property type="entry name" value="SSF101904"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56719">
        <property type="entry name" value="SSF56719"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6 9" id="KW-0413">Isomerase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0799">Topoisomerase</keyword>
    <feature type="domain" description="TOP4c" evidence="8">
        <location>
            <begin position="21"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="780"/>
            <end position="804"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PJN13117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="818" mass="88746" checksum="B35C006695CF7A34" modified="2018-04-25" version="1">MARRSTKTPPPDDFEERILDIDVVDEMQGSFLEYAYSVIYSRALPDARDGMKPVHRRIVYQMNEMGLRPDRGYVKCARVVGEVMGKLHPHGDASIYDALVRLAQPFSMRLPLVDGHGNFGSLGNDDPPAAMRYTECRMAPATSLMTESIDENTVDFGPNYDGQEREPAVLPAAYPNLLVNGASGIAVGMATNMPPHNLGEVIAAARHLIRHPGADLETLMKFVPGPDLPTGGRIVGLSGIKDAYESGRGTFKIRATVSVEDVTARRKGLVVTELPFAVGPEKVIAKIKDLVGSKKLQGIADVKDLTDRQHGLRLVIEIKNGFVPEAVLEQLYKLTPMEESFGINNVALVDGQPLTLGLKELLEVYLDHRFEVVRRRSEFRRTKKRDRLHLVEGLLVALVDIDEVIRLIRSSDNSAQAKERLMERFSLSEIQTQYILDTPLRRLTRFDRIELETERDRLNGEIDELTGILDSDAELRKLVSAELAAVAKKFGTERRTVLLESAGTAVAAAPLQVADDPCRVLLSSTGLLARTANAEPFGDDEDARRTKHDVIVSAVPATARGEIGAITSTGRLLRLNVIDLPQLPETASAPNLSGGAPVTEFLSSLEADEKVVCLTTLDESSPGLAIGTEQGVVKRVVPDYPTNKDELEVIGLKDGDRIVGAVELRTGEEDLVFITDDAQLLRYQASQVRPQGRAAGGMAGIKLTDGAKVISFTAVDPAVDAIVFTVAGSRGTLDDSVQTTAKLTPFDQYPRKGRATGGVRCQRFLKGEDCLSLGWAGPTPARAAQKNGTPAELPEVDPRRDGSGVSLAKTVSVVAGPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K2D1</accession>
    <name>A0A2M9K2D1_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Peptide-methionine (R)-S-oxide reductase</fullName>
            <ecNumber evidence="2">1.8.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">msrB</name>
        <name evidence="5" type="ORF">CG723_01410</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CB01635</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[thioredoxin]-disulfide + H2O + L-methionyl-[protein] = [thioredoxin]-dithiol + L-methionyl-(R)-S-oxide-[protein]</text>
            <dbReference type="Rhea" id="RHEA:24164"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="Rhea" id="RHEA-COMP:12313"/>
            <dbReference type="Rhea" id="RHEA-COMP:12314"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16044"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:45764"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="EC" id="1.8.4.12"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.8.4.12" evidence="2"/>
    <dbReference type="EMBL" id="NNBL01000001">
        <property type="protein sequence ID" value="PJN13273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN13273">
        <property type="protein sequence ID" value="PJN13273"/>
        <property type="gene ID" value="CG723_01410"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033743">
        <property type="term" value="F:peptide-methionine (R)-S-oxide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030091">
        <property type="term" value="P:protein repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028427">
        <property type="entry name" value="Met_Sox_Rdtase_MsrB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002579">
        <property type="entry name" value="Met_Sox_Rdtase_MsrB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011057">
        <property type="entry name" value="Mss4-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10173">
        <property type="entry name" value="PTHR10173"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01641">
        <property type="entry name" value="SelR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51316">
        <property type="entry name" value="SSF51316"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00357">
        <property type="entry name" value="TIGR00357"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51790">
        <property type="entry name" value="MSRB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MsrB" evidence="4">
        <location>
            <begin position="9"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PJN13273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="135" mass="15021" checksum="FD7ADD850847017A" modified="2018-04-25" version="1">MSYDVEKPDEEWRAELTPAEYAVLRQAGTEPAFVGEYTDTKTQGVYSCRACGAELFTSDEKFESHCGWPSFFDPKDTDAVELIADRSHGMVRTEVRCARCGSHLGHVFEGEGYPTPTDQRYCINSISLKLAPEAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K2G6</accession>
    <name>A0A2M9K2G6_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">NPCBM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_01730</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000001">
        <property type="protein sequence ID" value="PJN13326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN13326">
        <property type="protein sequence ID" value="PJN13326"/>
        <property type="gene ID" value="CG723_01730"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033926">
        <property type="term" value="F:glycopeptide alpha-N-acetylgalactosaminidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="CDD" id="cd14244">
        <property type="entry name" value="GH_101_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.1060">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018905">
        <property type="entry name" value="A-galactase_NEW3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025706">
        <property type="entry name" value="Endoa_GalNAc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040633">
        <property type="entry name" value="Gal_mutarotas_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040502">
        <property type="entry name" value="GalBD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014718">
        <property type="entry name" value="GH-type_carb-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035364">
        <property type="entry name" value="Glyco_hyd_101_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013222">
        <property type="entry name" value="Glyco_hyd_98_carb-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038637">
        <property type="entry name" value="NPCBM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18080">
        <property type="entry name" value="Gal_mutarotas_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17974">
        <property type="entry name" value="GalBD_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17451">
        <property type="entry name" value="Glyco_hyd_101C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12905">
        <property type="entry name" value="Glyco_hydro_101"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08305">
        <property type="entry name" value="NPCBM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10633">
        <property type="entry name" value="NPCBM_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00776">
        <property type="entry name" value="NPCBM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="SSF49785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014825400" description="NPCBM domain-containing protein" evidence="1">
        <location>
            <begin position="32"/>
            <end position="1296"/>
        </location>
    </feature>
    <feature type="domain" description="NPCBM" evidence="2">
        <location>
            <begin position="1150"/>
            <end position="1295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN13326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="1296" mass="137812" checksum="70838C2E0B68E084" modified="2018-04-25" version="1">MSRSPGRRRLSGAVGVALALTLAGGAVPALADSAHASSADADADAAGDGVAITSGALSVSVAKDFPRVLSYTDRASGARLLGSTSPVTEVTLNGKAYKVGLKAAPKVTAHRAAYTLVFPDLPGVEIDTVLDVAGRATTFKVTAVRDTETFRLGTLDIPGHDLISVGSTDTGAETAFTRLDTDSTRTADVFGKVTASTAPDASPVGASYAIVNTGSLAAAVESNSTYDKPAGATNGDNARFWHQARKGADGSVRVGVWSGQWTYRGDGAPAPEKELPWAKVVVTPDANGDKTVDWQDGAVAFHDIGVKVKGGDKTPDRVITHIPYNFASQATHPFLRTLDDVKRISLSTDGLGQLSILKGYASEGHDSAHPDYGGNINKRAGGLKDLDKLLKGGKKWGSTFGVHVNATEAYAEANAFDDKLVDKSKPGWNWLGQSYYIDQRHDINSGNLARRFQQLRDETDPNLSLVYIDVYYTHGWIADRTLTELKNQGWDMATEFGNKFERQALWSHWANDLDYGPKTNKGLNSKIVRFIRNGEKDVWNDDPVLGQTALVGFEGWTGENDWNEFSANVWERNLPAKFLQHYRITDWDKNDVTFTGGVRGTVTDGKREVSLGDSKVINGDSYLLPWKSEDSKRQDKLYHWSKKGGTSTWTVPRPFAGTGRFTVYELTDNGRVKQSTVTAEDGRITLTATAGQPYVLYPHQAPKQADPDWGQGGKVKDPGFNDITLADWKKTGPVTSDRDDLGHRGVALGGGKAAAIEQRVTGLTPGKRYSASVNVEVEPGKTRPTTLAVGGERLTVDRSTARNYIAGDERHGTYYQRVKVHFTAPANGSATLRISAAGDSDAKVGLDDVRIVENDPATKKGTVAYDDFDAVDQGWGPFVKGESGGENDPRTHIAQKHAPYTQAGWNGKLIDDVIGAGESLKSHEENDGLVYRTTPASVPFESGHAYKVEFDYQNSHAGAYQWTTGYDTVTGGEPTGVTTRRTALPQQRTTGHFSERVVGGCGDVWTGLTKAENAPEGADFVLDNFTVTDLGTTDERTACATLGLTSANATLEPGSANKVTAAFANHEATAAKNVEVTLDVPEGWKAEAAGATTFDSVAAGAKATATWNVTPPADAEYKSHPLTTKASYEAGGDTKSLTDGISIHTLAPPPTKDTWVSDMDWVSADNGWGPPEKDLSNGEVGSGDGQPISIGGTAFPKGLGTHAPADVKYYLGGGCAAFTAQVGVDDAQKTAGSVQFSVLADGRKVAESPVLKASDSAYELDADVSGAKYVELVVGDGGDGNGNDHASWGGAKWLCG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K2Q9</accession>
    <name>A0A2M9K2Q9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">AraC family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CG723_02175</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000001">
        <property type="protein sequence ID" value="PJN13403.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN13403">
        <property type="protein sequence ID" value="PJN13403"/>
        <property type="gene ID" value="CG723_02175"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003313">
        <property type="entry name" value="AraC-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020449">
        <property type="entry name" value="Tscrpt_reg_HTH_AraC-type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02311">
        <property type="entry name" value="AraC_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00032">
        <property type="entry name" value="HTHARAC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="3">
        <location>
            <begin position="150"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PJN13403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="248" mass="27161" checksum="E1E63AB4794DB9F1" modified="2018-04-25" version="1">MPNIRHTPQAPTRTQTLAAGGRIDPHRHDEHQIVYAGSGVLAVTTDAGTWFAPGTRAIWVPAGCVHAHRAHGHLALHTLGLPARVNPLGLDAPTVLTVSPLLRELLLAATRDPDEDSPESRRLRAVLLDQLRASPQQPLQLPTPTDPRLKAVCDLLYDDPADARPLAALGRASGAGERTLSRLFRRELGMTFPQWRTQLRLYHALRMLAEGEPVTAVAHRCGWSSTSAFIDVFRRAFGTTPGEHSRRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-09-29" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K2V8</accession>
    <name>A0A2M9K2V8_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 7">Uricase</fullName>
            <ecNumber evidence="5 7">1.7.3.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Urate oxidase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">pucL</name>
        <name evidence="8" type="ORF">CG723_02150</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CB01635</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5 7">Catalyzes the oxidation of uric acid to 5-hydroxyisourate, which is further processed to form (S)-allantoin.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 5 7">
            <text>H2O + O2 + urate = 5-hydroxyisourate + H2O2</text>
            <dbReference type="Rhea" id="RHEA:21368"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:17775"/>
            <dbReference type="ChEBI" id="CHEBI:18072"/>
            <dbReference type="EC" id="1.7.3.3"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 5">Purine metabolism; urate degradation; (S)-allantoin from urate: step 1/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5 7">Belongs to the uricase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.7.3.3" evidence="5 7"/>
    <dbReference type="EMBL" id="NNBL01000001">
        <property type="protein sequence ID" value="PJN13400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN13400">
        <property type="protein sequence ID" value="PJN13400"/>
        <property type="gene ID" value="CG723_02150"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00394">
        <property type="reaction ID" value="UER00650"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004846">
        <property type="term" value="F:urate oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006144">
        <property type="term" value="P:purine nucleobase metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019628">
        <property type="term" value="P:urate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002042">
        <property type="entry name" value="Uricase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42874">
        <property type="entry name" value="PTHR42874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01014">
        <property type="entry name" value="Uricase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000241">
        <property type="entry name" value="Urate_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00093">
        <property type="entry name" value="URICASE"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03383">
        <property type="entry name" value="urate_oxi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3 5 7" id="KW-0659">Purine metabolism</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Charge relay system" evidence="6">
        <location>
            <position position="12"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="6">
        <location>
            <position position="57"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="6">
        <location>
            <position position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR000241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000241-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU004455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PJN13400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="310" mass="35588" checksum="EF731FC903A87E97" modified="2018-04-25" version="1">MPTILGQNQYGKAENRVVKITRDGDTHHIKDLNVSVALSGDLDDVHYNGSNANCLPTDTTKNTCFAFAKEYGIESAEQYGIHLARHFVDSQPSIHRARIRIEEYSWERIAGSDGNSKFIGADEVKHSFVRKGQETRLAQITYDGEKFEVLSGLKDLTVMNSTNSEFWGYIKDKYTTLQEDYDRILATSLSTWWRHNWTSDEQRMPQWEKSYEQSKKHILQAFVETYSLSLQQTLYQMGSRVINNRSEIDEIRFSAPNKHHFRQDLSAFGLENEAKDGAVYYAADRPYGLIEATILRDGCEPHIPVDMTNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K386</accession>
    <name>A0A2M9K386_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">2-methylcitrate dehydratase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CG723_03260</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CB01635</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PrpD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000001">
        <property type="protein sequence ID" value="PJN13591.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN13591">
        <property type="protein sequence ID" value="PJN13591"/>
        <property type="gene ID" value="CG723_03260"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.4100.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036148">
        <property type="entry name" value="MmgE/PrpD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042183">
        <property type="entry name" value="MmgE/PrpD_sf_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042188">
        <property type="entry name" value="MmgE/PrpD_sf_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005656">
        <property type="entry name" value="MmgE_PrpD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045337">
        <property type="entry name" value="MmgE_PrpD_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045336">
        <property type="entry name" value="MmgE_PrpD_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16943">
        <property type="entry name" value="PTHR16943"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03972">
        <property type="entry name" value="MmgE_PrpD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19305">
        <property type="entry name" value="MmgE_PrpD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103378">
        <property type="entry name" value="SSF103378"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MmgE_PrpD" evidence="2">
        <location>
            <begin position="56"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="domain" description="MmgE_PrpD_C" evidence="3">
        <location>
            <begin position="232"/>
            <end position="381"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF19305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PJN13591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="407" mass="41538" checksum="AECA2C0FF4EFEF57" modified="2018-04-25" version="1">MPAIAESLAEWAYGYEPDAEDLALARRSLLDTVAVTLAARDHPVSALAAELPDAARWAAVGHVLDFDDLHIESTTHISVVIVPAVLAAGGDARAYLAGAGVMARLGTLLGWSHYAAGWHATCTAGAPAAAVAAGVAWGLTPTQLATAMALAVPGASGVQAAFGTHSKSLQVGFAAEAGVRAARLARAGATADPRAVDAWLKLVGAQGSGGTEGGAPRTGGPAVPGGLAIKMFPCCYAMQRPIAALRALRAECGPDDVTAVRVTTPGATIHPLIHDRPETGLEGKFSLPYAVATALLDGFPGFGAFTDEAVGRPEARRLMATVETERTEGGAGLLDGEVDLAVTLTDGRVLRSALAHPPGSPQRPPTDVELVEKFVACGSDVPALLKDTTWESARTLLLTELPGKAPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-05-25" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K387</accession>
    <name>A0A2M9K387_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Enoyl-CoA hydratase 2</fullName>
            <ecNumber evidence="1">4.2.1.119</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Enoyl-CoA hydratase 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CG723_02730</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CB01635</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>a (3R)-3-hydroxyacyl-CoA = a (2E)-enoyl-CoA + H2O</text>
            <dbReference type="Rhea" id="RHEA:26526"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:57319"/>
            <dbReference type="ChEBI" id="CHEBI:58856"/>
            <dbReference type="EC" id="4.2.1.119"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.119" evidence="1"/>
    <dbReference type="EMBL" id="NNBL01000001">
        <property type="protein sequence ID" value="PJN13497.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN13497">
        <property type="protein sequence ID" value="PJN13497"/>
        <property type="gene ID" value="CG723_02730"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002539">
        <property type="entry name" value="MaoC-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01575">
        <property type="entry name" value="MaoC_dehydratas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="SSF54637"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="2" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MaoC-like" evidence="5">
        <location>
            <begin position="12"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00029334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00030115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PJN13497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="170" mass="19335" checksum="3ABCB05245A3FC00" modified="2018-04-25" version="1">MQFGRTYEEFEVGAVYKHWPGKTVTEYDDHLFCLLTMNHHPLHMDTNYAENTTDFGKNVVVGNYIYSLLLGMSVPDVSGKAIANLEIESLRHVAPTFHGDTIYGETTVLDKTPSKSKNDRGIVYVETKGYKQDGTLVCVFRRKVMVPTETYIKERGGEQPGRPQLKEQEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K3F4</accession>
    <name>A0A2M9K3F4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Alpha-mannosidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CG723_03385</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CB01635</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 38 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000001">
        <property type="protein sequence ID" value="PJN13610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN13610">
        <property type="protein sequence ID" value="PJN13610"/>
        <property type="gene ID" value="CG723_03385"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004559">
        <property type="term" value="F:alpha-mannosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006013">
        <property type="term" value="P:mannose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041147">
        <property type="entry name" value="GH38_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011682">
        <property type="entry name" value="Glyco_hydro_38_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015341">
        <property type="entry name" value="Glyco_hydro_38_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037094">
        <property type="entry name" value="Glyco_hydro_38_cen_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000602">
        <property type="entry name" value="Glyco_hydro_38_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027291">
        <property type="entry name" value="Glyco_hydro_38_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028995">
        <property type="entry name" value="Glyco_hydro_57/38_cen_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09261">
        <property type="entry name" value="Alpha-mann_mid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17677">
        <property type="entry name" value="Glyco_hydro38C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07748">
        <property type="entry name" value="Glyco_hydro_38C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01074">
        <property type="entry name" value="Glyco_hydro_38N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00872">
        <property type="entry name" value="Alpha-mann_mid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="SSF74650"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88688">
        <property type="entry name" value="SSF88688"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="SSF88713"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha-mann_mid" evidence="5">
        <location>
            <begin position="519"/>
            <end position="598"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PJN13610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="1026" mass="112579" checksum="1B4C9A0A9283B0D6" modified="2018-04-25" version="1">MHDELRRIEQRVARVHDQRVKPAVHSARVPLALQAWHAPGEPVPFAEAKSAAYKPFSVGTPWGPPWGTTWFTAHGTVPAEWAGRRVEAVFDLGFVNDWPGNQAEALVHLPDGRPLKAVNPQNQYVPVARPAQGGEEVDYLIEAASNPDILADRFAHPTPLGDPRTAGDQPLYTFRSADLAILDEEVFHLSLDLQVLRELMLELSEHEPRRHEIAHTLEAALDALDLDDISGTAAAARAVLAPALAKPAHAGAHTLSSVGHAHIDSAWLWPIRETKRKTSRTFSNVTALADEYDEFVFACSQAQQYEWVKDNYPHVWDRIKEAVAKGQWAPVGGMWVESDGNLPGGEAVARQFVHGKRFFIEHFGVETKGVWLPDSFGYNAAYPQLARLAGNEWFLTQKLSWNQTNKLPHHSFWWEGIDGTRIFTHFPPVDTYNVEFSGKEMAHAVRNYQDKGRGTRSLAPFGHGDGGGGPTREMLERARRLADLEGSAKVRVEHPDAFFAEASKEIPKDQVWSGELYLELHRATYTSQARTKQGNRRSEHLLREAELWATAAALRAPGYAYPYEKLDRLWKTVLLHQFHDILPGSSIAWVHREAEAEYARVAAELEAITAEAVGALGGGEGGPHVFNTSPYARTEVIRTPAGDLARTHVPANGSAPLAPAAPDHPVTVTDGRTLDNGLVRVVIGPDGTLASVYDLTAEREVLAGPGNLLRLHSDLPNYWDAWDIDKHYKNHYRDLLDAESVTVTEEGPLRAAVRVERAFGKGSRITQTVTLRAGSKRVDVETEIDWHETEKILKAAFPVDVRADHSSAEIQFGHVKRPTHTNTSWEAARFEVYGHRWVHIGEPGYGVAVLNDSTYGHDVSRTTRDDGGTTTTVRLSLVRAPRVPDPEADQGAHRFTYSLLPGASVTDAVAEGYALNLPLRVAGSGGAPEPVVSVDGHGLTVEAVKLADDGSGDVVVRLYESLGGRAAGTLRTGFPLAGVQVTDLLERPLAEQPEEVRMPANGGDAVRVALRPFQIVTLRLAVGGRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K3H7</accession>
    <name>A0A2M9K3H7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Squalene--hopene cyclase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">shc</name>
        <name evidence="6" type="ORF">CG723_03770</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CB01635</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Secondary metabolite biosynthesis; hopanoid biosynthesis.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000001">
        <property type="protein sequence ID" value="PJN13672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN13672">
        <property type="protein sequence ID" value="PJN13672"/>
        <property type="gene ID" value="CG723_03770"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00337"/>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005811">
        <property type="term" value="C:lipid droplet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016866">
        <property type="term" value="F:intramolecular transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016104">
        <property type="term" value="P:triterpenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02892">
        <property type="entry name" value="SQCY_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006400">
        <property type="entry name" value="Hopene-cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032696">
        <property type="entry name" value="SQ_cyclase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032697">
        <property type="entry name" value="SQ_cyclase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018333">
        <property type="entry name" value="Squalene_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008930">
        <property type="entry name" value="Terpenoid_cyclase/PrenylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11764">
        <property type="entry name" value="PTHR11764"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13243">
        <property type="entry name" value="SQHop_cyclase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13249">
        <property type="entry name" value="SQHop_cyclase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01016">
        <property type="entry name" value="Prenyltransferase_Like_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48239">
        <property type="entry name" value="SSF48239"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01507">
        <property type="entry name" value="hopene_cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01787">
        <property type="entry name" value="squalene_cyclas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="SQHop_cyclase_N" evidence="5">
        <location>
            <begin position="42"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="domain" description="SQHop_cyclase_C" evidence="4">
        <location>
            <begin position="338"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF13249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PJN13672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="669" mass="74169" checksum="79093BE7B8F47C32" modified="2018-04-25" version="1">MTATTDGSSGAAAPGATSATTAHLTDTSPGAAGTHDAATRSVQRATDFLLARQDAQGWWKGDLDTNVTMDAEDLLLRQFLGIGDEATTRAAGLFIRGEQRDDGTWATFHGGPGELSTTIEAYVALRLAGDAPDEPHMAKASAWIRERGGIAASRVFTRIWLALFGWWKWDDLPELPPELIYFPKWMPLNIYDFGCWARQTIVPLTVVSAKRPVRPAPFRLDELHTDARNPNPAKPLAPVASWDGAFERLDKAMHLYRKVAPRRLRKAAMNSAARWIIERQENDGCWGGIQPPAVYSVIALHLVGYDLEHPVMKAGLESLDRFAVWREDGARMIEACQSPVWDTCLAVIALADAGLPADHPRLVKAADWMLREQIDRPGDWSVRRPQLASGGWAFEFHNDNYPDIDDTAEVVLALRRVRHPDRTRMEKAIERGVRWNLGMQSKNGAWAAFDVDNTSPFPNRLPFCDFGEVIDPPSADVTGHVVEMLAVEGMSHDPRTRRGIEWLLAEQEPNGAWFGRWGVNYVYGTGSVLPALTAAGLPPSHPAVRRAVTWLESVQNDDGGWGEDLRSYRYEDWKGHGVSTASQTGWALMALLSAGERDSKAVERGVAWLTETQLEDGTWDEPYFTGTGFPWDFSINYHLYRHVFPLTALGRYVHGEPFADQAALTGKGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K3N9</accession>
    <name>A0A2M9K3N9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CG723_03885</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CB01635</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GPN-loop GTPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000001">
        <property type="protein sequence ID" value="PJN13690.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN13690">
        <property type="protein sequence ID" value="PJN13690"/>
        <property type="gene ID" value="CG723_03885"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004130">
        <property type="entry name" value="Gpn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03029">
        <property type="entry name" value="ATP_bind_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PJN13690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="198" mass="21615" checksum="C81434CCC6E8A7B7" modified="2018-04-25" version="1">MDYDDSSDAFPTALKILVAGGFGVGKTTFVGAVSEIAPLSTEELLTTVSAETDDLEGIENKVETTVAMDFGRITLDPEHVLYLFGTPGQERFWFMWDELSEGALGAVILADTRRLEDCFAAVDFFEERGMGFIVAVNEFDGAYRYDPDEVRAAIDLDPQVPVVRCDARISSSGIQTLLTLVRHLLAHAPAQTTYGAHT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K3P3</accession>
    <name>A0A2M9K3P3_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">MPAB_Lcp_cat domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_03620</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000001">
        <property type="protein sequence ID" value="PJN13647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN13647">
        <property type="protein sequence ID" value="PJN13647"/>
        <property type="gene ID" value="CG723_03620"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018713">
        <property type="entry name" value="MPAB/Lcp_cat_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09995">
        <property type="entry name" value="MPAB_Lcp_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MPAB_Lcp_cat" evidence="1">
        <location>
            <begin position="18"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF09995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN13647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="287" mass="32889" checksum="6E41B4C9F3C839B9" modified="2018-04-25" version="1">MKQHDLDPEPPPPGGILWDIAGEVRSLLALPAALTLQVAHPAVGAGVDEHSVFRTDPWGRGERSLRSVMLWVYGGEDAAQEGRRLRQLHRTIRGTDTRGRSYHALTPEYYAWVHATGFPVYRQAQRYLGRRPFTEAQERRLYAEWLQVGRILGLHDRDMPQTVEEFWPYYRKVLADEIELTAVVRELVAVDAPVPPPDRGPLPVRLALRALWPLLLPPLARFRRFLTIGLMPPDAREAIGLPWTPVQERRLRRFGAVVRRVVPLLPERLRYLPMARRARAAETARAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K3R7</accession>
    <name>A0A2M9K3R7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">GntR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_02290</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">In the C-terminal section; belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000001">
        <property type="protein sequence ID" value="PJN13765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN13765">
        <property type="protein sequence ID" value="PJN13765"/>
        <property type="gene ID" value="CG723_02290"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044249">
        <property type="term" value="P:cellular biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="CDD" id="cd07377">
        <property type="entry name" value="WHTH_GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
        <property type="entry name" value="GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00035">
        <property type="entry name" value="HTHGNTR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00345">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50949">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH gntR-type" evidence="2">
        <location>
            <begin position="21"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN13765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="480" mass="51392" checksum="7D1DDF4A55C95C00" modified="2018-04-25" version="1">MNGSLGSRRLAGLLTVTAGERPGYRALAQGVRTLLLDGRIPLHTRLPAERELATALGVSRATVTAAYDLLREGGYARSRRGAGTWTELPEGQRPASVAVFPTGDDVIDLAIAAPGAPEAELADALAAAGAQLPRHASTPGYHPYGLPELRAAVAERFTRRGLPTLPEQILITSGAQQAVSLTLGLLARAGDRVLVENPSYPNALDALNRGGMRATPVPVTDGGWDTDLFESALRQTAPRLAYLIPDFHNPTGRLMPREQRVRLLEAARATGTWLVVDETVADIALDVPAPAPFASLASPGAGEQVVTVGSLSKSHWGGLRIGWVRAGSRLITELATARVPFDMSGSVLDQLVALRLLDRMDEVLSERLPRMRAQRDALAEDLARELPEWRWQLPPGGLSLWIDLGRPIASALARAALRHGVHIEGGSRFGADPGTHEHRLRFPYTQPPEVAREAVHRLAQTLADGLGATGDEPGRPHWVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K3S3</accession>
    <name>A0A2M9K3S3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Aspartate aminotransferase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_03795</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000001">
        <property type="protein sequence ID" value="PJN13677.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN13677">
        <property type="protein sequence ID" value="PJN13677"/>
        <property type="gene ID" value="CG723_03795"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044249">
        <property type="term" value="P:cellular biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="CDD" id="cd00610">
        <property type="entry name" value="OAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005814">
        <property type="entry name" value="Aminotrans_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00202">
        <property type="entry name" value="Aminotran_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000521">
        <property type="entry name" value="Transaminase_4ab_Lys_Orn"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00600">
        <property type="entry name" value="AA_TRANSFER_CLASS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="1 2" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN13677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="461" mass="50392" checksum="FB625BB2E3E4A35E" modified="2018-04-25" version="1">MSKEFDLARLLADRGAERYELHAKYLNHQLPRMLHTIGFDKVYERAEGAYFWDEDGNDYLDMLAGFGVMGLGRHHPVVRKALHDVLDASLADLTRFDCQPLPGLLAERLLAHSPHLDRVFFGNSGTEAVETALKFARYATGRPRVLYCGHAFHGLTTGSLSVNGESGFRDGFAPLLPDTAVPLGDLDALRAELAKGDVAGLIVEPIQGKGVHGTPPGYLRAAQELLHQHKALLIADEVQTGLGRTGDFYAYQHDEGVEPDLVCVAKALSGGYVPVGATLGKDWIFKKVYSSMDRVLVHSASFGSNAQAMAAGLAVLSVMENEEVVANARATGELLKSRLAALVDRYELLSDVRGRGLMIGIEFGRPKSLKLRSRWTMLQAARKGLFAQMVVVPLLQKHRILTQVSGDHLEVIKLIPPLIIGEHEVDRFVEAFTAVMDDAHSGGGLMWDFGKTLVKQAVANR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JEJ3</accession>
    <name>A0A2M9JEJ3_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">RDD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CG723_45585</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CB01635</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000059">
        <property type="protein sequence ID" value="PJN05299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN05299">
        <property type="protein sequence ID" value="PJN05299"/>
        <property type="gene ID" value="CG723_45585"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010432">
        <property type="entry name" value="RDD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06271">
        <property type="entry name" value="RDD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="23"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="54"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="106"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="domain" description="RDD" evidence="7">
        <location>
            <begin position="17"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="265"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="266"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF06271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PJN05299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="308" mass="31146" checksum="F34877387673D0B1" modified="2018-04-25" version="1">MSELVTGEAVALELRPAKLPSRALAVVIDLVVAFTVYILVTMGIVASTASLDQAAAAAVAVATFLLVLVGVPIAVETLSHGRSLGKLACGLRVVRDDGGPIRFRHALVRGAVGVVEILMTFGVVACIASLVSERGRRLGDVFAGTLVVRERVPAGPARFVPPPPPWLVGRFSGLDLSGVPDGLWLAVRSYLTRMGQLDPQVGHSMAERLAGDLAACTGAPAPGDVPPAAYLAAVVHERQSRDARRAFGGGAGAAAPVGGPRPVYPGAATPVGPPVGPAVAAAAPPTSDVTAAGPREDEGPGTGFVPPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-09-29" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JER3</accession>
    <name>A0A2M9JER3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycerol acyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_45080</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000050">
        <property type="protein sequence ID" value="PJN05384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN05384">
        <property type="protein sequence ID" value="PJN05384"/>
        <property type="gene ID" value="CG723_45080"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002123">
        <property type="entry name" value="Plipid/glycerol_acylTrfase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01553">
        <property type="entry name" value="Acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00563">
        <property type="entry name" value="PlsC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PlsC" evidence="2">
        <location>
            <begin position="137"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="54"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN05384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="350" mass="38673" checksum="93A93F6A45368338" modified="2018-04-25" version="1">MADAKVIPFDDDRSRTGAGKVVPRRRGASVRRKGEPAAVREVAPLPEQQDHEPTPPAAAREPEPRERPQAGGGLDRRIAGGLAFLRRRLTGDYDVDEFGYDKELTDQVLMSLVRPLYEKYFRVEVKGIENIPADGGALIVANHSGTLPLDGVMMQVAVHDNHPQNRHLRLLAADLVFMLPVVNELARKAGHTLACAEDAQRLLEQGELVGVMPEGFKGIGKPFSERYKLQRFGRGGFVSTALRAGTPIVPCSIVGAEEIYPMIGNAKTLARLLGFPYFPITPTFPWLGPLGAVPLPTKWTIQFGEPIPTDGFPPEAAEDPMLMFNLTDQVREQIQHTLYKLLVQRRSVFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JEV8</accession>
    <name>A0A2M9JEV8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">GPP34 family phosphoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_44560</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000048">
        <property type="protein sequence ID" value="PJN05435.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN05435">
        <property type="protein sequence ID" value="PJN05435"/>
        <property type="gene ID" value="CG723_44560"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043231">
        <property type="term" value="C:intracellular membrane-bounded organelle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070273">
        <property type="term" value="F:phosphatidylinositol-4-phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3630.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008628">
        <property type="entry name" value="GPP34-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038261">
        <property type="entry name" value="GPP34-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05719">
        <property type="entry name" value="GPP34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN05435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="217" mass="23941" checksum="A3A32E20CBF6E28B" modified="2018-04-25" version="1">MDLTLPQQIYLCTYAFTKNKFPATLLQFRGQRVRAAALTELVLAGQAETDGRRVRALGDQSPTDPFLASVWEELHARPKKWMALVHNTAHKAEKPVENQLTAAGIIEKKTGRTLSLLGGSKVVLRREEEARAVQQVLRTRVTTTPDPSTLPLAQVALPVIALESDATMGVVLNRSERRIHKDTLEELAKKFDREIPGLRKALSNSVLSSRAVGGGWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JF22</accession>
    <name>A0A2M9JF22_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_44590</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000048">
        <property type="protein sequence ID" value="PJN05469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN05469">
        <property type="protein sequence ID" value="PJN05469"/>
        <property type="gene ID" value="CG723_44590"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="222"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="276"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="305"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN05469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="391" mass="40133" checksum="916BF495C6AD4DBD" modified="2018-04-25" version="1">MAAALTQPQDRRPEHAVAGRSHAELQRTLDRLGTNLLTASPGRTFTGGEAKLPERSIDMAGRIAPVESATGTGKVTAYVYRNDHIPAAETGSINVKAARLDLLDTVGGSLARGNWLNAATAKYPAVVLGSGAADRLGIGEVGPDIRVWLGGQWFSVVGILDEALLAPELNDSALVGWDAAKRYLGFDGHPTTIYVRTADSAVTSVRDVLAAKGATDKAFTGLMLGLGGVALLVGGVGVANTMVISVLERRAEIGPRRALGARRGDIRTQFLAESQLLAGLGGIAGVVIGVDVTTAYAVAQGWPAVVPAWAMAGGLLATLAIGALAGLYPAVRASRLPPTEALSGACSQAGTSKVWMPDRVVPVPIRSCSMILLNTNGGPRAAARAAARGGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JF66</accession>
    <name>A0A2M9JF66_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">IS5/IS1182 family transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_44785</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000048">
        <property type="protein sequence ID" value="PJN05462.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN05462">
        <property type="protein sequence ID" value="PJN05462"/>
        <property type="gene ID" value="CG723_44785"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025161">
        <property type="entry name" value="Put_IS4/IS5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002559">
        <property type="entry name" value="Transposase_11"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01609">
        <property type="entry name" value="DDE_Tnp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13340">
        <property type="entry name" value="DUF4096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDE_Tnp_1" evidence="1">
        <location>
            <begin position="96"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN05462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="263" mass="29932" checksum="300B295485EF4181" modified="2018-04-25" version="1">MTDLEWAQVRPLLPVPGWLRGRGGQPEAYCHRAMLDAVRYLVDNGIKWRALPIDFPPWDRVYAFFRQWRDHGLVREFHDRLRGQVRTRLGRDAEPTAGVIDSQSVKADAVVGMDSRGFDGGKLINGRKRHVVVDTLGLLLAVMVTAADTGDRLAAHALLRQVADAHYQLAVIWADGGYTGSLIEYSLAVLGLVVAIVKRSDDVRGFVVLPKRWIVERLFAHLMRSRRLVRDFERRTSSAESVIYWSMTMLMTRRLARPHPRRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JG29</accession>
    <name>A0A2M9JG29_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">AfsR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CG723_42680</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CB01635</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AfsR/DnrI/RedD regulatory family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000040">
        <property type="protein sequence ID" value="PJN05841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN05841">
        <property type="protein sequence ID" value="PJN05841"/>
        <property type="gene ID" value="CG723_42680"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd15831">
        <property type="entry name" value="BTAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005158">
        <property type="entry name" value="BTAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03704">
        <property type="entry name" value="BTAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01043">
        <property type="entry name" value="BTAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0902">Two-component regulatory system</keyword>
    <feature type="domain" description="OmpR/PhoB-type" evidence="5">
        <location>
            <begin position="1"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="3">
        <location>
            <begin position="1"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="242"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="680"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="687"/>
            <end position="702"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PJN05841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="1091" mass="117777" checksum="114AF32F98DFC89B" modified="2018-04-25" version="1">MRYRILGVTEAYDDQGTPLPVGGQRLRALLTSLALHAGRTAPADALIGDVWADEPPADATAALQALVGRLRRVLGKDAVTSEAGGGYRLAARPDDVDLYVFERLVGEGTAALTAHDPATASRALRDALALWRGPALADLADRTAATRPEAQRLEAARARVEADLQLGRAADVVPELTELTHAHPYDEPLHALLIRALRDAGRGADALAAYETARHTLADGLGADPGPELAALYADLLDPARVHAGDSGRPAPPRQPQRAGNLRPRLNSFVGREPELDAIRSDLQAARLVTLTGPGGSGKTRLAEEAAAEHPRAWLAELAPLDQPEAVAGAVVSALGLRETVLMTSEHSAPQDDPVALLVEHCAQRSLLLILDNCEHVIGAAAELAETLLTHCPGLTVLATSREPLGVPGESVRPVEPLPPDPAHRLFDERARAVRPDFDVTGDPEAVAEICRRLDGLPLAIELAAARLRLLTPRQIADRLDDRFRLLTSGSRTVLPRQQTLRAVVDWSWDLLDEQERTVLREASVFAGGWDLEAAEAVCTGPASDLIGALVDKSLLVATPGHGSMRYRMLETIHEYATERAAETPLLRTEAERRHVACFRALVEKADPLLRSAEQLPWIERLETELDNIRAALHRSTVTGDTEAAVELALSTGWFWWLRNYRREGAEWVGHILEELLPTPRPERPAPSECRGPRSDRRTFPAAGDLADEDDPLYWPLMELRLLHIFFVAQSEPESALRGEADREYLVRVRDAFARPGPVGARFPGIIWPFTVHFLDNPEDVRAALDRAIANCRVYGGEWEIGVTLMFRTHTAVDGPGNLTGVDDDVAELRTISRRVGDRWMRAQVCSAAGEAAIARSRFDEAKGEFEEALRLAYEVGAYAEAPFLIARLGEIAYRSGEPDAARKLLAEASGEADRYGVPDPHAYVHLLNALMAVEDGEVARARALCDEAARESSRGTPPPQFTAAVGGVDARITAAESGPARGLAVLTDALRYAVETRCAEIVNAGLAGRGALFLAQLGDTEGAVRLVAASDGWLGGAERPLPERAEIEALEAEAVAALGADRYAEARAAGAGHTAAEAVTHLTERVRRFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JGM4</accession>
    <name>A0A2M9JGM4_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Trypco2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_41210</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000036">
        <property type="protein sequence ID" value="PJN06028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN06028">
        <property type="protein sequence ID" value="PJN06028"/>
        <property type="gene ID" value="CG723_41210"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045608">
        <property type="entry name" value="Trypco2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19631">
        <property type="entry name" value="Trypco2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Trypco2" evidence="1">
        <location>
            <begin position="3"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF19631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN06028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="127" mass="13629" checksum="3CBECD31E5BDB971" modified="2018-04-25" version="1">MGIGLSEALAEHREELYQAQEDGSGERFRFEVESAELKLTVEFRKGGDGKVKVSAGAEGVEAGGTVASTTSHRPALKLNIRDGALGGTRAVIGRNAPEAPPLPELAMAPGHRQRVRATPVRKYLRRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JGR4</accession>
    <name>A0A2M9JGR4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Integrase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_41480</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000036">
        <property type="protein sequence ID" value="PJN06069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN06069">
        <property type="protein sequence ID" value="PJN06069"/>
        <property type="gene ID" value="CG723_41480"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.443.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013762">
        <property type="entry name" value="Integrase-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002104">
        <property type="entry name" value="Integrase_catalytic"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00589">
        <property type="entry name" value="Phage_integrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="SSF56349"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51898">
        <property type="entry name" value="TYR_RECOMBINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyr recombinase" evidence="2">
        <location>
            <begin position="146"/>
            <end position="360"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN06069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="512" mass="57878" checksum="2D34B37EF61A6830" modified="2018-04-25" version="1">MDPAAVAVESGLADVVTLQRRRQARVSAHDEESFFLDTLSEYQWARDAAGLAPATLDGLVKPVIEVCNYYGTVPWQLSPREVDRYFARPGKRASSTLRAKINKIDAYFAFLEQRYAGEIMRRFGAAVESPIDLFNRPRHRGDFGLRIPPSQTAMCDFFSRWREDLPNARKYFVACRNYVMTKVAYLSGVRAAELCGVCMGDIHWEHGQWGRFVVQGKGARASGPRPREAYMFQEGRALLWWYIEEIRGEFGDDAEHPRAPLWPSERKPTAVAALNLPIAPAIVPSTFRRSLHAAATNYLTGPVADLFPHLLRHACATHNYERGMTLWEVQKVLGHDWATTTLRYMATAHADPEVANLAASSQAAQRLVAIHALPGEELRTILTTDLNLARGTLEVRRGLLRHTLYLEEFTHRLASEWLAYRHHRWPASTNPCLLVSQKTALDPDHPVVSRTLLRRTLPKNVTLVGLRQDRMLNEAFATGDPLKLMRLFGITAQTAMRYVAAAYPERTARLPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JHE3</accession>
    <name>A0A2M9JHE3_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Bac_luciferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_39805</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000032">
        <property type="protein sequence ID" value="PJN06291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN06291">
        <property type="protein sequence ID" value="PJN06291"/>
        <property type="gene ID" value="CG723_39805"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011251">
        <property type="entry name" value="Luciferase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036661">
        <property type="entry name" value="Luciferase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00296">
        <property type="entry name" value="Bac_luciferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51679">
        <property type="entry name" value="SSF51679"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bac_luciferase" evidence="1">
        <location>
            <begin position="13"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN06291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="281" mass="29014" checksum="5FDA7BB277294A45" modified="2018-04-25" version="1">MTTPLLVGRIATHGTDAPTLDGLTAVARAAEAAGLDALILDDAAGAPGRQAPFETTTLAAALAARTDRIGLIVSPLPADQAPYHVARIVASLDHLGRGRTGWLAGAADAEGRTAELIEVARGLWDSFDDDAYVHDRADGQYWRLDTIHQLDHRGRHFDVAGPLNVARPPQGHPVVAVRGPALAADADLVLLDDPADVPAVRSSAPGAKVLVPLLDHADAEGLLAASGADGLTVALSGAHDPFLTTTAPTLRRSGAPQPADTTLRARLGLSRPASRYATGTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-09-29" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JIB3</accession>
    <name>A0A2M9JIB3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CG723_38595</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CB01635</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000028">
        <property type="protein sequence ID" value="PJN06608.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN06608">
        <property type="protein sequence ID" value="PJN06608"/>
        <property type="gene ID" value="CG723_38595"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd16913">
        <property type="entry name" value="YkuD_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.440.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041280">
        <property type="entry name" value="Big_10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005490">
        <property type="entry name" value="LD_TPept_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038063">
        <property type="entry name" value="Transpep_catalytic_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17964">
        <property type="entry name" value="Big_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03734">
        <property type="entry name" value="YkuD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141523">
        <property type="entry name" value="SSF141523"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014993645" evidence="4">
        <location>
            <begin position="41"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="domain" description="Big_10" evidence="6">
        <location>
            <begin position="75"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="domain" description="YkuD" evidence="5">
        <location>
            <begin position="258"/>
            <end position="392"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF03734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF17964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PJN06608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="422" mass="44078" checksum="65F96E886DC88194" modified="2018-04-25" version="1">MEMRVMTDSKRRKGLMAASALVGGVLVLSACSGGGSEARGADGGGTKSQAAVDEAAAKKTSEALIKIAPKNGSDNASINNAAAVTVSKGSLTNVKMTTVEGAAVQGQISADKKSWKPAGQLQRATVYKIAAEAKDSSGRAAHENSTFTTVSQANSFIGNFTPEDGSTVGVGMPVSINFDKAITNKADVQKGITVSSSSGQEVVGHWFGNQRLDLRPQDYWTGGSTVTLKLNLDGVEGANGVYGVQQKTVTFKIGRNQVSTVDAATKTMTVTRDGKVVKTIPISAGSPENKTYQGQMVISEKFKETRMDGSTVGFKDDDGKGEYDIKDVPHAMRLSNSGTFIHGNYWGAKSIFGGANTSHGCVGLSDAKGANDPNTPGAWFYDNSMVGDVVVVKNTGDKTIQPDNGLNGWNLDWAQWTAGSAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JIL9</accession>
    <name>A0A2M9JIL9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">tRNA-specific adenosine deaminase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_37250</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000026">
        <property type="protein sequence ID" value="PJN06731.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN06731">
        <property type="protein sequence ID" value="PJN06731"/>
        <property type="gene ID" value="CG723_37250"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002125">
        <property type="entry name" value="CMP_dCMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016193">
        <property type="entry name" value="Cytidine_deaminase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00383">
        <property type="entry name" value="dCMP_cyt_deam_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53927">
        <property type="entry name" value="SSF53927"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51747">
        <property type="entry name" value="CYT_DCMP_DEAMINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CMP/dCMP-type deaminase" evidence="1">
        <location>
            <begin position="7"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN06731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="152" mass="16591" checksum="10438BF9FC2F2020" modified="2018-04-25" version="1">MSAFDPELARTWLATAVEEARAGLAEGGIPIGAALYSADGKVLGRGHNRRVQDADPSVHGETDAFRNAGRQRSYKGTTMVTTLSPCWYCSGLVRQFGISRVVVGEARTFHGGHDWLAEHGVEIVMLDDPECVAMMEEFIAARPELWNEDIGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JIW4</accession>
    <name>A0A2M9JIW4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Site-specific integrase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CG723_37695</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000026">
        <property type="protein sequence ID" value="PJN06808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN06808">
        <property type="protein sequence ID" value="PJN06808"/>
        <property type="gene ID" value="CG723_37695"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.443.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013762">
        <property type="entry name" value="Integrase-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002104">
        <property type="entry name" value="Integrase_catalytic"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="SSF56349"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51898">
        <property type="entry name" value="TYR_RECOMBINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyr recombinase" evidence="3">
        <location>
            <begin position="233"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="304"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PJN06808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="453" mass="50236" checksum="4A892487A2F62251" modified="2018-04-25" version="1">MGTTYDVRIWAVRQRKDRKQASAELRWKTGDTPHSQTFQTKTLAEGRRAELLRAVHAGEPFDEETGVPVKELRDRNDVSWYQHALDYIAMKWPHSPGSTRRTLAEAMATVTPVLVKDTKGMADARTVRAALYSWAFNMTRRGEEPPADVAKVLDWFERKSLPTSALSDRMRVRTALDALTKKLDGTTAAASTIRRKRAIFHNALGYAVDADRLPANPLPQVQWKAPEQVADEVDPACVPGPRQTAALLSAVRAQGPRGRRMVAFFGCMYFAAARPAEVIGLRLADCDLPRRGWGTLRLRETRPRSGSAWTDTGESHDRRGLKHRPRKAVRVVPIPPDLVALLRWHVTAYGVSPDGRLFRTLRGGIIQDTGYGEVWAEARRRALTPAQYASTLAKRPYDLRHAAVSTWLSSGVEPQAVAQRAGHSVAVLFRVYAKCLDGAAATANARIEAALKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JJ03</accession>
    <name>A0A2M9JJ03_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_36825</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000025">
        <property type="protein sequence ID" value="PJN06849.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN06849">
        <property type="protein sequence ID" value="PJN06849"/>
        <property type="gene ID" value="CG723_36825"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010539">
        <property type="entry name" value="UCP009160"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41282">
        <property type="entry name" value="PTHR41282"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12811">
        <property type="entry name" value="BaxI_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF009160">
        <property type="entry name" value="UCP009160"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="76"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="109"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="135"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="161"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="194"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="229"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="268"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="19"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN06849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="295" mass="31107" checksum="8F9982B82A8B207B" modified="2018-04-25" version="1">MRSSNPVFSRRGFSRDNGYAGFNAQPQAGGPAVGTQGNPYAGDNPYAQNPYAQQDLQYGAPPQAPATTGRMTMDDVVMRTATTLGVLVVTAALAWALLPVDDAHINKSYGIAIGAGLIAMVLGFVQAFKRKASPALILTYAGLEGVFLGVLSSIVDNRIASGAAMQAVIGTMAVFVAVLVAYKAGWIRVNRRFYGFVMAAAMGFILLMAVNLLFSVFGGGDGLGFRSGGLGIVFGIIGVLLGACFLALDFKQVEDGIAYGAPREEAWLAAFGLTMTLVWIYLEFLRLIAILQGND</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JJ06</accession>
    <name>A0A2M9JJ06_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CG723_36880</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CB01635</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000025">
        <property type="protein sequence ID" value="PJN06858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN06858">
        <property type="protein sequence ID" value="PJN06858"/>
        <property type="gene ID" value="CG723_36880"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="32"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="60"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="91"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="153"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="186"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="28"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PJN06858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="223" mass="23490" checksum="F95570667A801CD7" modified="2018-04-25" version="1">MYELFKNLGAWLVDGDQWAGPDGIGHRLAEHLQYSLLATLIAAVIALPLGLLIGHTGRGAFLAINLSSFGRALPTVGLVVLVFLASGLSMWPVYIALVALAVPSIVTNTYAGMSAVDPEVRDAARGQGMRGHQVLFQVELPLAMPLIMTGLRLALIQVVATATIAAYVSFGGLGRYVFDGLAQRDLVQVLGGAVLVAVVAVVLDLALSALQRALFRHRPAKSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JJG1</accession>
    <name>A0A2M9JJG1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CG723_36540</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CB01635</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000024">
        <property type="protein sequence ID" value="PJN06992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN06992">
        <property type="protein sequence ID" value="PJN06992"/>
        <property type="gene ID" value="CG723_36540"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="75"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="111"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="143"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="199"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="242"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="75"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PJN06992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="280" mass="30019" checksum="2E35AE78FB03DDD1" modified="2018-04-25" version="1">MNSPTLLRRRAATAGFHLGAGALAVLWLVPIVLVVITATRTFDDIAANGLGSAPHSFSLDGFRQAWTEGGQKQALINSLLVTVPSVLISLLLASMAAFALSRYSLPGRRTLLLVMLAGNLLPPQILLIPVSKMSELVGIYDSLWALIGVQVGFGIGFYVFVLHGFMRSIPPEVQQAAVIDGAGPATIYWRIVLPLARPALAALSALSFTWIFNDLLWAISVLRTETHMPITASLINLQGQYVSQWNVIAAGSVIAAAPTVLVFLRFQRHFVAGLNLGAVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JJG7</accession>
    <name>A0A2M9JJG7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Aldose epimerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CG723_36580</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000024">
        <property type="protein sequence ID" value="PJN07021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN07021">
        <property type="protein sequence ID" value="PJN07021"/>
        <property type="gene ID" value="CG723_36580"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09022">
        <property type="entry name" value="Aldose_epim_Ec_YihR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008183">
        <property type="entry name" value="Aldose_1/G6P_1-epimerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014718">
        <property type="entry name" value="GH-type_carb-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037480">
        <property type="entry name" value="YihR-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01263">
        <property type="entry name" value="Aldose_epim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="SSF74650"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PJN07021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="299" mass="32114" checksum="867990C669923946" modified="2018-04-25" version="1">MPLSGTQLPLTAGPYTATVAGVGATLRELDYGGRPLILGFDADEPAPAAHGQLLAPWPNRLAQGRYAFDGAEHQLALDEQEPPSALHGLVAWQTWTPQPHDDAHGVRLALDLAARPGYPFALRLLAEYRLDADSGLTARVTVVNRSSRPAPFGLGAHPYLTFGGSIDRCSVQLAADHCLHPDAHMLPDGKPRPVQGTPHDLRSPRQLTGTVLNHAYTGLHRDSDGLAWARLRAPEGDAVDLWADASFGWLQLYTADHFGRTGLAVEPMTCPPDAFNSGHDVIVLAPGEQWSAAWGIRVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JJV7</accession>
    <name>A0A2M9JJV7_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Urease subunit alpha</fullName>
            <ecNumber evidence="5">3.5.1.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Urea amidohydrolase subunit alpha</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">ureC</name>
        <name evidence="13" type="ORF">CG723_34770</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">CB01635</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5 10">
            <text>2 H(+) + H2O + urea = CO2 + 2 NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:20557"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16199"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="EC" id="3.5.1.5"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5 7 10">
            <name>Ni cation</name>
            <dbReference type="ChEBI" id="CHEBI:25516"/>
        </cofactor>
        <text evidence="5 7 10">Binds 2 nickel ions per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 5">Nitrogen metabolism; urea degradation; CO(2) and NH(3) from urea (urease route): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">May form a heterohexamer of 3 UreC (alpha) and 3 UreAB (gamma/beta) subunits. May also form a heterotrimer of UreA (gamma), UreB (beta) and UreC (alpha) subunits. Three heterotrimers associate to form the active enzyme.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5 9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="6">Carbamylation allows a single lysine to coordinate two nickel ions.</text>
    </comment>
    <comment type="PTM">
        <text evidence="5">Carboxylation allows a single lysine to coordinate two nickel ions.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5 11">Belongs to the metallo-dependent hydrolases superfamily. Urease alpha subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.5" evidence="5"/>
    <dbReference type="EMBL" id="NNBL01000022">
        <property type="protein sequence ID" value="PJN07161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN07161">
        <property type="protein sequence ID" value="PJN07161"/>
        <property type="gene ID" value="CG723_34770"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00258">
        <property type="reaction ID" value="UER00370"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016151">
        <property type="term" value="F:nickel cation binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009039">
        <property type="term" value="F:urease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043419">
        <property type="term" value="P:urea catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00375">
        <property type="entry name" value="Urease_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01953">
        <property type="entry name" value="Urease_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011612">
        <property type="entry name" value="Urease_alpha_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017950">
        <property type="entry name" value="Urease_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005848">
        <property type="entry name" value="Urease_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017951">
        <property type="entry name" value="Urease_asu_c"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029754">
        <property type="entry name" value="Urease_Ni-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01979">
        <property type="entry name" value="Amidohydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00449">
        <property type="entry name" value="Urease_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01752">
        <property type="entry name" value="UREASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="SSF51338"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01792">
        <property type="entry name" value="urease_alph"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01120">
        <property type="entry name" value="UREASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00145">
        <property type="entry name" value="UREASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51368">
        <property type="entry name" value="UREASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 5 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 5 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 5 7" id="KW-0533">Nickel</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Urease" evidence="12">
        <location>
            <begin position="136"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="5 8 9">
        <location>
            <position position="327"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5 7">
        <location>
            <position position="141"/>
        </location>
        <ligand>
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5 7">
        <location>
            <position position="143"/>
        </location>
        <ligand>
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" description="via carbamate group" evidence="5 7">
        <location>
            <position position="224"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5 9">
        <location>
            <position position="226"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5 7">
        <location>
            <position position="253"/>
        </location>
        <ligand>
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5 7">
        <location>
            <position position="279"/>
        </location>
        <ligand>
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5 7">
        <location>
            <position position="367"/>
        </location>
        <ligand>
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="modified residue" description="N6-carboxylysine" evidence="5 6">
        <location>
            <position position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR611612-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR611612-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR611612-52"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000510"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PJN07161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="573" mass="60872" checksum="41BBB4395F1817EF" modified="2018-04-25" version="1">MAELSRAAYADLFGPTTGDRIRLADTDLLIEIEEDRSGGPGLSGDESVFGGGKVIRESMGQSRATRADGAPDTVITGAVIVDHWGIVKADIGIRDGRITAIGKSGNPDTMDGVHPDLVIGPETEILAGNGKIVTAGAIDTHIHFISPTIVDEALASGVTTLIGGGTGPAEGSKATTITPGSWHLARMFEAMESSPVNIGFLGKGNTTSAESMYAQLRGGAVSFKIHEDWGATPAVIDACLNVCEDTGAQLAVHTDTLNEAGFVDATFDAVAGRTLHAFHVEGAGGGHAPDMITAVSLPNMLPSSTNPTRPHTVNTVEEHLDMLMVCHHLNPAVPEDLAFAESRIRPTTIAAEDILHDIGAISIMSSDSQAMGRIGEVVLRTWQTAHVMKRRRGLLPGDTRADNLRARRYVAKYTINAAVAQGIDHEIGSVETGKLADLVLWDPRFFGVKPQLVIKGGQIAYAQMGDANASIPTPQPVLPRPMFGAHGRAPASNSFFYVTQTALDDGLPERLRLDRKFVPIRSTRGRTKADMRENDALPRVEVAPDSFAVTIDGELVEPAPAAELPLAQRYFLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JK13</accession>
    <name>A0A2M9JK13_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_35085</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000022">
        <property type="protein sequence ID" value="PJN07216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN07216">
        <property type="protein sequence ID" value="PJN07216"/>
        <property type="gene ID" value="CG723_35085"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="60"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="83"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="181"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="20"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="191"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN07216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="318" mass="33144" checksum="71A1A6F48E93DA26" modified="2018-04-25" version="1">MWPGEQGPGGEQNPQGRQPNPYQQPNPFPQPPGQQVWNAPTMPAGSPQPSPEPPKRRRTALIAVVAAAAVVVASVVTGVLVLGGDKDKKDDNAGPGPTTSSAAAPSATGNPRAGGGVEPTVHGWKTVVNTDHGLAFDVPSTWLVKSNGWVNWVSKDGDPREKPLIAMSNPAFLEEKWCVSDDDKDGNEEESSLGATGSRGNNGAKSTEEAATKDATMWVYGAYSQPDKKSITTKPAESYTTASGLNGSLVTASSTGVKQKKHGKCSSDGKAAVFAFKDADGDFASWSFFGPTGVKGEVPDATVRKILSTARLVDVSDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JK38</accession>
    <name>A0A2M9JK38_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_35185</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000022">
        <property type="protein sequence ID" value="PJN07235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN07235">
        <property type="protein sequence ID" value="PJN07235"/>
        <property type="gene ID" value="CG723_35185"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011717">
        <property type="entry name" value="TPR-4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07721">
        <property type="entry name" value="TPR_4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="157"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN07235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="183" mass="19575" checksum="70FA8052240E6BBB" modified="2018-04-25" version="1">MAEQREQAADDAMMARIGQVIMLHHAGDREEARDRYLGLWAEIGEDGDALHRCTLAHYMADAQDDPDHELAWDLRALSAAEGLTEARLARHEQSLAVRALYPSLHLNLAADYVKLGRPDAARSHLTQARAVVGALGDDGYGDGVRAAIARLAQRVAAMPPGADEGPGRGSAGGEPLGPPRRSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-06-02" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JK84</accession>
    <name>A0A2M9JK84_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">GNAT family N-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_34980</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000022">
        <property type="protein sequence ID" value="PJN07197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN07197">
        <property type="protein sequence ID" value="PJN07197"/>
        <property type="gene ID" value="CG723_34980"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="2">
        <location>
            <begin position="317"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="76"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="78"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN07197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="487" mass="52334" checksum="B223D6919209A131" modified="2018-04-25" version="1">MSPDMSDVRRAKNGRPVHHWRRDVVELAALFTAVAVADAVANLVGHGPDGPALLAISAVALLATAGFHTWWARRHNHAPPTGDTDARRLPTEHAGRSGQPDTEVPAGAGPQATNEATATALWRMRTTVRDEPGSLAALCTALAPLRVDILSLQTHPLGEGTVDEFLLRAPQDLPAAELTRNVSLAGGSGTWIERADAHDLVDAPTRILGLATRTALDAAELPLALRQLLGRCTIRSLPATTMGGRRTESAPVEGALEGTMIRLRAPEGGVITVERPYLPFTPTEFARARALVELDARLGPRIPRSQDVLTLPEGKAITVRRADSNDVEAAKEMQERCSRATLSKRYHGPVGDADRYLNHLLSPRFGRTLAAQTASGRIVALGHLLWDGDETEIALLVEDDWQRRGIGTELLGRLVAMAVEAGCESVYAVTQASNTGMVAAMRGLGLPLDYQIEEGTLVITARLETTAVRSRLPYEGPRAAYEPADRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JKB3</accession>
    <name>A0A2M9JKB3_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Probable primosomal protein N'</fullName>
            <ecNumber evidence="9">3.6.4.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">ATP-dependent helicase PriA</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">priA</name>
        <name evidence="12" type="ORF">CG723_34215</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">CB01635</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of the primosome.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the helicase family. PriA subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.-" evidence="9"/>
    <dbReference type="EMBL" id="NNBL01000021">
        <property type="protein sequence ID" value="PJN07310.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN07310">
        <property type="protein sequence ID" value="PJN07310"/>
        <property type="gene ID" value="CG723_34215"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990077">
        <property type="term" value="C:primosome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006269">
        <property type="term" value="P:DNA replication, synthesis of RNA primer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006268">
        <property type="term" value="P:DNA unwinding involved in DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1440.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00983">
        <property type="entry name" value="PriA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005259">
        <property type="entry name" value="PriA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041222">
        <property type="entry name" value="PriA_3primeBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042115">
        <property type="entry name" value="PriA_3primeBD_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17764">
        <property type="entry name" value="PriA_3primeBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 9" id="KW-0235">DNA replication</keyword>
    <keyword evidence="8 9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6 9" id="KW-0347">Helicase</keyword>
    <keyword evidence="5 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="1 9" id="KW-0639">Primosome</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <keyword evidence="9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PriA_3primeBD" evidence="11">
        <location>
            <begin position="54"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C4-type" evidence="9">
        <location>
            <begin position="433"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="167"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="648"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="696"/>
            <end position="716"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="651"/>
            <end position="665"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF17764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PJN07310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="716" mass="75243" checksum="60BD91242486F44F" modified="2018-04-25" version="1">MSSENGQGDGGGEGAPPEQLALIRESVRQAKVPRAKPRTWRGAALAKELPVARVLVDKGVLHLDRYFDYAVPEELDADAQPGVRVRVRFGAGKHSVRDGRREGGGLIDGFVVARVAESEYQGPLAALAQVVSPEPVLGEELLGLARAVADRYAGSLADVLQLAVPPRNARAEKKPSPEPLPPPPAPDAGSWRRYERGPGFLDALASGGAPRAVWNALPGPEWADEVARAVAATLSSGRGALVVVPDGRAVARVDAALSAVLGEGRHAVLTADAGPEKRYREWLGVRRGAVQAVVGTRAAMFAPVRDLGLVVIWDDGDSSHAEPHAPQPHARDVLLLRAAHDKCAFLLGSWSCTVEAAQLVESGWAAPLIAGREQVRGAAPLVRTVGDGDLARDEAARAARLPTLAWQAVREGLKRGPVLVQVPRRGYVPRLACERCREPARCRHCAGPLEASEGTAALKCGWCGQEERAWQCQECGGFRLRAQVVGARRTAEELGRAFPAVPVRTSGREQVLDTVPGAPALVVSTPGAEPVAEGGYAAALLLDGWAMLGRPDLRAGEDALRRWIAAASLVRPQGTGGTVVIVAEPTLRPVQALVRWDPVGHAVRELSERAELGFPPVSRMAAVSGAPEALAGFLAAVELPGDAEVLGPVPVPDAAPGPSRRPGAPPPGEHWERVLVRVPPGSGAALASALKHAQAARMARGGTEPVRVRVDPPDIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JKI9</accession>
    <name>A0A2M9JKI9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CG723_34625</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CB01635</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GPN-loop GTPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000021">
        <property type="protein sequence ID" value="PJN07386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN07386">
        <property type="protein sequence ID" value="PJN07386"/>
        <property type="gene ID" value="CG723_34625"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004130">
        <property type="entry name" value="Gpn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03029">
        <property type="entry name" value="ATP_bind_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PJN07386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="201" mass="22039" checksum="C9D866B35E4382B7" modified="2018-04-25" version="1">MIFGRSERGKPPVEPVTLKILVAGGFGVGKTTLVGAVSEIKPLRTEELLSEAGRPLDDTRGVEGKHTTTVAMDFGRITLREDLVLYLFGTPGQDRFWFLWDELATGALGAVVLADTRRLEDCFAAVDYFERRSIPFVVGVNCFEGSARYPADAVRQALDLDSDVPVLMCDAREKETVKEVLIGVVEHAMAVGARRRQPVTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JKK8</accession>
    <name>A0A2M9JKK8_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Barstar domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_34250</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the barstar family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000021">
        <property type="protein sequence ID" value="PJN07317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN07317">
        <property type="protein sequence ID" value="PJN07317"/>
        <property type="gene ID" value="CG723_34250"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.370.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000468">
        <property type="entry name" value="Barstar"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035905">
        <property type="entry name" value="Barstar-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01337">
        <property type="entry name" value="Barstar"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52038">
        <property type="entry name" value="SSF52038"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Barstar" evidence="2">
        <location>
            <begin position="12"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN07317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="119" mass="13323" checksum="AAC68F7C1A0FE1D6" modified="2018-04-25" version="1">MTGGPPDRIRVLDLEGVKDKAGFMDRCVRDLELPDWFGRNWDALFDVLTDVSFWPDGSDQALLLSVVGWRAYASARPEDWETALDVFTDAVDRRRGRNPRLVIALTLGGSDHAPSRPPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JKN2</accession>
    <name>A0A2M9JKN2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">DNA-binding response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CG723_33530</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000020">
        <property type="protein sequence ID" value="PJN07426.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN07426">
        <property type="protein sequence ID" value="PJN07426"/>
        <property type="gene ID" value="CG723_33530"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00383">
        <property type="entry name" value="trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3 7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="5">
        <location>
            <begin position="8"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="domain" description="OmpR/PhoB-type" evidence="6">
        <location>
            <begin position="133"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="3">
        <location>
            <begin position="133"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="231"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PJN07426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="253" mass="27616" checksum="CA2E4E60D04525B6" modified="2018-04-25" version="1">MQTPPLGRVLVVDDDPTVAEVVAGYLDRAGYDVDRAADGPAALDRADAHGPDLVVLDLMLPGMDGLEVCRRLRARGPVPVIMLTARGDEDERILGLEVGADDYVTKPFSPRELVLRVESVLRRARAATAPKPAGPLRAAALAIDPAARRATKSGDELALTIREFDLLAFFLRHPGRAFSREELMQQVWGWDFGDLSTVTVHVRRLRGKIEDDPAAPRLIQTVWGVGYRLDPGGPHSDAVQPDRAPADWTEPRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JKZ1</accession>
    <name>A0A2M9JKZ1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Histidine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CG723_32685</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000019">
        <property type="protein sequence ID" value="PJN07533.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN07533">
        <property type="protein sequence ID" value="PJN07533"/>
        <property type="gene ID" value="CG723_32685"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013767">
        <property type="entry name" value="PAS_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00989">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PAS" evidence="5">
        <location>
            <begin position="152"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="1288"/>
            <end position="1404"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="623"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="661"/>
            <end position="935"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="956"/>
            <end position="1180"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="299"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="694"/>
            <end position="712"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="961"/>
            <end position="982"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="983"/>
            <end position="1040"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1053"/>
            <end position="1067"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1088"/>
            <end position="1130"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="1337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PJN07533.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="1410" mass="145540" checksum="6F5121FB5E223C73" modified="2018-04-25" version="1">MSSRPSRGAARLAAILDALPDALVLVNANGTVVNANTIALEAFEAPGTALVGRGLLDLLPEFDSRLIPGSMRRPDTTDERGRTKPTRMMARRTDGSEFPVEVTSANLADGRDTVDGYGNSSYGSYGGEAELLMLVVRDLSGTVDTEAELARSQRQTEMILRAAAEGVVGTDTDGRIVLVNPAAAQILGFRASDLGGQELHALVLHSRADGEPFPYEESPLADTLRSGRKHRVRGQVLWSKSGTQVPVDMTTAPVRDGDQLVGAVMTFTDRRPYDELVVAHTEEIDRRDKETERAATEHAETLARTVEEHEAQTARAEEEHAAELATITEQHTEELSAEKDRIAALAEREKDRYEALAARHEQLLAVLGQSLRGPLDELRGQLTTLAADDAGQLWPEANQILHHLAAGYSRMTTLVDNVLGYQLLDSGDAQLTRTKVMLDAVVAAGVDGAVELIGPGRAQFAVHAPPIEAEVDAARLATALAHLVADVAGIDATGNARVGVVPTSGVGGYVDSTIVVAAALRGESVRIEVRGPYTGGDPVHEPIVRGIVRAHGGVLQTHEVPGMSGSAYVLEVPIGGGAGAVAVADPSGVVGAAVPGTAVEVASQAGPAGPAGAETGAVAGALLPEQASGTRGGRRRARRASGASVDSFLESGVAGAAGAVPEADEAGQGGGGSEVVAPTGRRRRRAEDGATAGTPGSAQRQLPAQATQTPAGGTPAGDAGVGTGTGRRRGRPNPAEVAVPEGAAGPGAAEGSVMTAAEHAAGAPALGETVPPQGVPVGASSGRRARRNSEPAALPAGGSGRAGASDASQAGQNVPAERRARRALGSAPEREAEQGSTARTVFALPPAEADRTTPEPDAATGADTDATTATGRGAGGERHDAAQGHPSDDHTPPQPHPVQTVPAARAALPPENGARPRAAQPLPAEAPSADPNSTQGRAISVRTLGQGVPFGRQIAEQQRPPRPQPAAPGTAQPLPSPQPNSPAAAQPNRANRPSQANPADPTTGKQPGPQAKQASGTQGGPSGPKSEQQPVQSAGGNPSLQVPLPPQVPQPAAAPQEQTQHTLGGSGRRRRLSTRPDPAGTQPETAARPHPQAPSQSSPAQPKAQPKTPSGQSQPGQPQSLLSTSSEGRGRSYAIGAPDQDADEGPEPLDGPGGAVELAIRPQPQPMDDELPPEPLDNPRRLLVWPAPDATTQQALSDRGYRPVTVHSREEVDAQIAAFPAALFVDPLTGPITRTALQSLRQAAVAAEVPVLVTAGLGQATREAAYGADPAVLLKALAPRDSEQHPSRVLLIEEREEIALALTATLERRGMQVARAGSDADAVTLAAQMRPNLVVMDLLQVRRRRAGIVDWLRANGQLNRTPLVVYTAAVEEAELPRLAAGETVLFLAERSTSDEVQGRIVDLLAKIGTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JLA7</accession>
    <name>A0A2M9JLA7_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">FMN dependent NADH:quinone oxidoreductase</fullName>
            <ecNumber evidence="6">1.6.5.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Azo-dye reductase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">FMN-dependent NADH-azo compound oxidoreductase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">FMN-dependent NADH-azoreductase</fullName>
            <ecNumber evidence="6">1.7.1.17</ecNumber>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">azoR</name>
        <name evidence="8" type="ORF">CG723_33395</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CB01635</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Also exhibits azoreductase activity. Catalyzes the reductive cleavage of the azo bond in aromatic azo compounds to the corresponding amines.</text>
    </comment>
    <comment type="function">
        <text evidence="6">Quinone reductase that provides resistance to thiol-specific stress caused by electrophilic quinones.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>2 a quinone + H(+) + NADH = 2 a 1,4-benzosemiquinone + NAD(+)</text>
            <dbReference type="Rhea" id="RHEA:65952"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
            <dbReference type="ChEBI" id="CHEBI:134225"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>anthranilate + N,N-dimethyl-1,4-phenylenediamine + 2 NAD(+) = 2-(4-dimethylaminophenyl)diazenylbenzoate + 2 H(+) + 2 NADH</text>
            <dbReference type="Rhea" id="RHEA:55872"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15783"/>
            <dbReference type="ChEBI" id="CHEBI:16567"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:71579"/>
            <dbReference type="EC" id="1.7.1.17"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="5">
            <dbReference type="Rhea" id="RHEA:55874"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
        <text evidence="6">Binds 1 FMN per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the azoreductase type 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.6.5.-" evidence="6"/>
    <dbReference type="EC" id="1.7.1.17" evidence="6"/>
    <dbReference type="EMBL" id="NNBL01000019">
        <property type="protein sequence ID" value="PJN07655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN07655">
        <property type="protein sequence ID" value="PJN07655"/>
        <property type="gene ID" value="CG723_33395"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016652">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H, NAD(P) as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016655">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01216">
        <property type="entry name" value="Azoreductase_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003680">
        <property type="entry name" value="Flavodoxin_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023048">
        <property type="entry name" value="NADH:quinone_OxRdtase_FMN_depd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02525">
        <property type="entry name" value="Flavodoxin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52218">
        <property type="entry name" value="SSF52218"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 6" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="2 6" id="KW-0288">FMN</keyword>
    <keyword evidence="4 6" id="KW-0520">NAD</keyword>
    <keyword evidence="3 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flavodoxin_2" evidence="7">
        <location>
            <begin position="4"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="10"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="17"/>
            <end position="19"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="97"/>
            <end position="100"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="136"/>
            <end position="139"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01216"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PJN07655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="219" mass="23311" checksum="A2BAE053D5717089" modified="2018-04-25" version="1">MPTLLHIDSSVWPGSASASRTVADAFRKTWEEQHPDGTVIYRDLAVNPVPHLDTVGASAGFADPATHSPEQAAAFAGRRELIEELEQADAVLIGAPMYNFSIPSTLKAWLDQVILMGRTAGETPSAKGTPVTVVASRGGSYAPGTPREPFEYVQNYLRDLLGTMLGLDVAFIVPELTLAHTTPAMSELIPLAEASRAKALEEADARAKELAARFSADAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-09-29" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JLD8</accession>
    <name>A0A2M9JLD8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Elongation factor G-like protein EF-G2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CG723_31945</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CB01635</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000018">
        <property type="protein sequence ID" value="PJN07691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN07691">
        <property type="protein sequence ID" value="PJN07691"/>
        <property type="gene ID" value="CG723_31945"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd16262">
        <property type="entry name" value="EFG_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01434">
        <property type="entry name" value="EFG_mtEFG1_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03713">
        <property type="entry name" value="EFG_mtEFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041095">
        <property type="entry name" value="EFG_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009022">
        <property type="entry name" value="EFG_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035647">
        <property type="entry name" value="EFG_III/V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035649">
        <property type="entry name" value="EFG_V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000640">
        <property type="entry name" value="EFG_V-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004161">
        <property type="entry name" value="EFTu-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005517">
        <property type="entry name" value="Transl_elong_EFG/EF2_IV"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00679">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14492">
        <property type="entry name" value="EFG_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03764">
        <property type="entry name" value="EFG_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03144">
        <property type="entry name" value="GTP_EFTU_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00838">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00889">
        <property type="entry name" value="EFG_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="SSF50447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54980">
        <property type="entry name" value="SSF54980"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="5">
        <location>
            <begin position="22"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="716"/>
            <end position="735"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="721"/>
            <end position="735"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PJN07691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="735" mass="78548" checksum="DE6BF0CD266923FF" modified="2018-04-25" version="1">MGDKANTHPGAAGRATAADHPSSVRNVVLVGHSGSGKTTLVEALALTAGAVNRAGRVEDGTAVSDYDDIEHRQQRSVQLSLVPLEWDGYKINLLDTPGYADFVGELRAGLRAADAALFVVSASDGPETMAGATRMVWEECAAVGMPRAIVVTHLEAARSDFEQMTRTCETFFGGDDPDAVIPLYLPLHGEPGPDGHAPVTGLVGLLSQRVFDYASGERKESEPDSDQLPLIEEARNRLIEGIIAESEDETLMDRYLSGEEIDYKTLVGDLERAVARGVFHPVLAAAPAAQGARQGIGTVELLELITGGFPTPLERAAPLVTTPSGEARTVNVCDPDGPLVAEVVKTASDPYVGRISLVRVFSGTLRPDDTVHVSGHGLADRGHEDHDVDERIGALSSPFGKQQRVLSHCIAGDLACVAKLGRAETGDTLSAKDNPLLMEPWDMPDPLLPLAIQAHSKPDEDKLSQGLSRLVAEDPTMRLEQNQDTHQVVLWCLGEAHADVALERLRNRYGVQVDVVPHKVSLRETFADRSAGRGRHVKQSGGHGQFAICEIEVEPLPNGSGIEFVDKVVGGAVPRQFIPSVEKGVRAQAAKGVAAGHPLIDVRITLLDGKAHSVDSSDAAFQTAGALALREAAADARIHLLEPVAEVQVLVADDYVGAVMSDLSGRRGRVVGTEQTPGSRTLVRAEIPEIEIGRYAVDLRSLSHGTGRFSRAYARHEPMPPQLGDRMREQAEDVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JLI8</accession>
    <name>A0A2M9JLI8_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 5">Argininosuccinate lyase</fullName>
            <shortName evidence="5">ASAL</shortName>
            <ecNumber evidence="3 5">4.3.2.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Arginosuccinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5 8" type="primary">argH</name>
        <name evidence="8" type="ORF">CG723_32205</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CB01635</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 5">
            <text>2-(N(omega)-L-arginino)succinate = fumarate + L-arginine</text>
            <dbReference type="Rhea" id="RHEA:24020"/>
            <dbReference type="ChEBI" id="CHEBI:29806"/>
            <dbReference type="ChEBI" id="CHEBI:32682"/>
            <dbReference type="ChEBI" id="CHEBI:57472"/>
            <dbReference type="EC" id="4.3.2.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 5">Amino-acid biosynthesis; L-arginine biosynthesis; L-arginine from L-ornithine and carbamoyl phosphate: step 3/3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the lyase 1 family. Argininosuccinate lyase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.3.2.1" evidence="3 5"/>
    <dbReference type="EMBL" id="NNBL01000018">
        <property type="protein sequence ID" value="PJN07735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN07735">
        <property type="protein sequence ID" value="PJN07735"/>
        <property type="gene ID" value="CG723_32205"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00068">
        <property type="reaction ID" value="UER00114"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004056">
        <property type="term" value="F:argininosuccinate lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042450">
        <property type="term" value="P:arginine biosynthetic process via ornithine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01359">
        <property type="entry name" value="Argininosuccinate_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.275.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00006">
        <property type="entry name" value="Arg_succ_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029419">
        <property type="entry name" value="Arg_succ_lyase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009049">
        <property type="entry name" value="Argininosuccinate_lyase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024083">
        <property type="entry name" value="Fumarase/histidase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020557">
        <property type="entry name" value="Fumarate_lyase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000362">
        <property type="entry name" value="Fumarate_lyase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022761">
        <property type="entry name" value="Fumarate_lyase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008948">
        <property type="entry name" value="L-Aspartase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43814">
        <property type="entry name" value="PTHR43814"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14698">
        <property type="entry name" value="ASL_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00206">
        <property type="entry name" value="Lyase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00149">
        <property type="entry name" value="FUMRATELYASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48557">
        <property type="entry name" value="SSF48557"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00838">
        <property type="entry name" value="argH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00163">
        <property type="entry name" value="FUMARATE_LYASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="4 5" id="KW-0055">Arginine biosynthesis</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 8" id="KW-0456">Lyase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lyase_1" evidence="6">
        <location>
            <begin position="21"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="domain" description="ASL_C2" evidence="7">
        <location>
            <begin position="372"/>
            <end position="439"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012338"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF14698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PJN07735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="475" mass="51190" checksum="6D7721A814D07BBA" modified="2018-04-25" version="1">MSSNTGDVRLWGGRFADGPAEALAKLSASVHFDWRLAPYDIAGSRAHARVLHKAGLLTEDELTRMLAGLDQLEADVADGSFVGTIADEDVHTALERGLLERLGVDLGGKLRAGRSRNDQVATLFRMYLRDHARVIGGLVTDLQDALVGLAEAHADVAMPGRTHLQHAQPVLFAHHVLAHVQSLSRDAERLRQWDERTAVSPYGSGALAGSSLGLDPEAVAKDLGFEHGSAANSIDGTASRDFVAEFAFITAMIGVNLSRIAEEIIIWNTKEFSFVTLHDAFSTGSSIMPQKKNPDIAELARGKSGRLIGNLTGLMATLKALPLAYNRDLQEDKEPVFDSCDQLEVLLPAFTGMMATLTVNRERMEELAPAGFSLATDIAEWLVKQGVPFRVAHEVAGECVKECEQHGIELDQLTDDQFAKISEHLTPEVRTVLNVQGALASRGGRGGTAPSAVAVQLAEVKDDLAVQRAWAEAKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JLJ4</accession>
    <name>A0A2M9JLJ4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Histidine phosphatase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CG723_32265</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000018">
        <property type="protein sequence ID" value="PJN07746.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN07746">
        <property type="protein sequence ID" value="PJN07746"/>
        <property type="gene ID" value="CG723_32265"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00300">
        <property type="entry name" value="His_Phos_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="SSF53254"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PJN07746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="191" mass="20283" checksum="66E49EA6A360FD88" modified="2018-04-25" version="1">MPVRVTLLAAARSASLLAERFDDDRPLDHTGWHEVELASPALVPLAAAELRYCAPTARSRGTAEALGLAPLSQLALRDCDMGRWRGRTLAEVTAVEPGAVDAWLRDPRSAPHGGESLLAFISRVGGWLDTRPNDDGATVVAVAEPAVVRAALVYALKAPPSTYWNIDVRPLSTAVLTGSAGRWSVRLDAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JLN1</accession>
    <name>A0A2M9JLN1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Pseudouridylate synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_32485</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000018">
        <property type="protein sequence ID" value="PJN07784.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN07784">
        <property type="protein sequence ID" value="PJN07784"/>
        <property type="gene ID" value="CG723_32485"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140098">
        <property type="term" value="F:catalytic activity, acting on RNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009982">
        <property type="term" value="F:pseudouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034470">
        <property type="term" value="P:ncRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001522">
        <property type="term" value="P:pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006224">
        <property type="entry name" value="PsdUridine_synth_RluC/D_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006145">
        <property type="entry name" value="PsdUridine_synth_RsuA/RluA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00849">
        <property type="entry name" value="PseudoU_synth_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="SSF55120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01129">
        <property type="entry name" value="PSI_RLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PseudoU_synth_2" evidence="1">
        <location>
            <begin position="102"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN07784.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="324" mass="35755" checksum="B85EAFF76B7C99F6" modified="2018-04-25" version="1">MRRKRRIPPSPLPQRDGIDAFRVMLPLDGAWSTVRDHLVERLAAGPGVIDAMLRDGRIVGADGAAVTSDAPYVPGAWVWFHRDLAPEVPVPFPIGIVYRDEHIVVADKPHFLATTPRGSHVTQTALARLRQELDLPALGPAHRLDRLTAGLVLFVVRPAERGAYQTLFGDKLVRKEYEAVAAHDPGVALPRTVRSRIEKERGVLAAREVPGGEPNAESRIELVEERGGLGRYRLLPHTGRTHQLRVHMNALGLPILGDPIYPVVADAVAPDDFRRPLQLLARTLEFRDPMTGREHRFDSGRVLEAWSAHEEWAGGSPTAPAHPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JLR6</accession>
    <name>A0A2M9JLR6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DNA-binding response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CG723_32645</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000018">
        <property type="protein sequence ID" value="PJN07814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_018535046.1">
        <property type="nucleotide sequence ID" value="NZ_NNBL01000018.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN07814">
        <property type="protein sequence ID" value="PJN07814"/>
        <property type="gene ID" value="CG723_32645"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00622">
        <property type="entry name" value="HTH_LUXR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="4"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="domain" description="HTH luxR-type" evidence="3">
        <location>
            <begin position="151"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PJN07814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="223" mass="24081" checksum="846B0CDD12AFC162" modified="2018-04-25" version="1">MAIRVLLVDDQPLLRTGFRMILEAEQDIAVVGEAGDGLQALDQVRALQPDVVLMDIRMPRMDGVEATRQITGPGRDGPAKVLVLTTFDLDEYVVEALRAGASGFLLKDAPANELVQAIRVVAAGEAMLAPSITRRLLDKYADHLPSGDEPVPDTLHTLTEREVEVLKLVARGLSNAEIAADLFVSETTVKTHVGHVLTKLGLRDRVQAAVYAYESGLVRPGAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JLU2</accession>
    <name>A0A2M9JLU2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_31165</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000017">
        <property type="protein sequence ID" value="PJN07861.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN07861">
        <property type="protein sequence ID" value="PJN07861"/>
        <property type="gene ID" value="CG723_31165"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN07861.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="199" mass="21043" checksum="4F046C0612F06C73" modified="2018-04-25" version="1">MTQPGQRSARESRGHARIVSEAARGTVELRPAHQGDTPAVQEQRPTVQELTGPVDDALLAYLAETYPAVADGTAIPVRADMVRPGMDVIAAVCLEDRTVGTVKAFNGPTPWVRLTCTTRTHADSVMGDARVFEPGHHLIVTVDSLARLYGPADPRATVAEERPAAEALAADPIPAAAFVLEGMPGRPNGAMTEAASRPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JMI2</accession>
    <name>A0A2M9JMI2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Taurine dioxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CG723_30815</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000016">
        <property type="protein sequence ID" value="PJN08075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08075">
        <property type="protein sequence ID" value="PJN08075"/>
        <property type="gene ID" value="CG723_30815"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042098">
        <property type="entry name" value="TauD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003819">
        <property type="entry name" value="TauD/TfdA-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02668">
        <property type="entry name" value="TauD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TauD" evidence="3">
        <location>
            <begin position="45"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PJN08075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="311" mass="34746" checksum="C2200CC4694269D7" modified="2018-04-25" version="1">MQAVASTHVTNPKPVLDKPLMHYGRRVLERLAPGAEQSAYRLIDIDPLTPHFGAVLGGVDLTRPISDELAAELRQALLEWKVIFFRGQTGFTAEHQLALSGIWGPPEANPFFAKTGTAGISRLAKDAKAAGNKNIWHSDHSFMANPSLGAVLRAVEVPAAGGDTMWADMGAAYDNLPEDLKERIANLTAVHDWEASWGALMDDQQKAAFRESWPQVEHPVVVRHPRSGRRTLYVNEPFTRYIKGLTEAENRELLDILVLQARIPEFQIRFRWEADSIAVWDNIAVQHYAVNDYFPQRRVMERIAIAGVPLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-09-29" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JMQ1</accession>
    <name>A0A2M9JMQ1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ATP-dependent helicase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_29515</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000015">
        <property type="protein sequence ID" value="PJN08146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08146">
        <property type="protein sequence ID" value="PJN08146"/>
        <property type="gene ID" value="CG723_29515"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0347">Helicase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="1">
        <location>
            <begin position="32"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="2">
        <location>
            <begin position="247"/>
            <end position="398"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN08146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="714" mass="77494" checksum="E21BE2F42E2E28E4" modified="2018-04-25" version="1">MSAVDELEPALVHHIVNTLGWKGLRPLQEAAVEPLSAGEDALLLAPTAGGKTEAACFPLLSRMHRARWSGTSVLYLCPLKALLNNLLPRVETYASWLGRGAALWHGDTTSGNRKRILADRPDVLLTTPESLEAMLVSVNVDHASFFSGLRAVVVDEVHAFASDDRGWHLLAVLERLQRVVGRPLQRVGLSATVGNPGELLTWLQGSGAGTRPAQVVAPHLDAPRDAASGAPPVSVPSGDIQLDYVGSLENAATVISTLHRGEKRLVFCESRRLVEELGSALRARGVVTFLSHASLSLDERRRAEAAFAEARDCVIVSTSTLELGIDVGDLDRVVQIDAPASVASFLQRIGRTGRRPGTSRNCLFLALDRTGLLSAAGLLLQWSRGWVEPVVAPPEPRHIVAQQLLALCLQEGGVGSNLWHEGWNGLGPFGPSAQPIVKHLVTEGYLDQDDGLLFIGPEAERRFGHRHFMNLTAVFTAPPQFTVLQGRTEIGRTDPSLLTEHIAGPRRLLLAGRNWQVTYIDWKRKRCFVEPADGGGKAKWSGAGFGQGASFRLVRAVRDVLLGADPPVHLTRRAHGCLGEAREYFMERVHPGGTLIVRERGRPDQLRWWTWAGHRANATLAATLGGAAVPGQRLNDHWVRLRDDLTPTDWKLARQDVTENLALPDIDEKAVRGLKFGDALPARLAEATLSIRLADLESAAVVLSEQVRFTGGGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JMW4</accession>
    <name>A0A2M9JMW4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">RNA polymerase sigma factor SigE</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CG723_29795</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CB01635</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000015">
        <property type="protein sequence ID" value="PJN08199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08199">
        <property type="protein sequence ID" value="PJN08199"/>
        <property type="gene ID" value="CG723_29795"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050896">
        <property type="term" value="P:response to stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039425">
        <property type="entry name" value="RNA_pol_sigma-70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013249">
        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43133">
        <property type="entry name" value="PTHR43133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08281">
        <property type="entry name" value="Sigma70_r4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="6">
        <location>
            <begin position="75"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4_2" evidence="7">
        <location>
            <begin position="173"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="36"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="221"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF08281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PJN08199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="257" mass="28175" checksum="1709099C08537CD9" modified="2018-04-25" version="1">MVGAPLDTTRADRGGAAAPVDRGGVLRRFLRSAGEPKSVTNTADRSNAARPAQTATFAADAESQAWTPPTWEEIVSTHSGRVYRLAYRLTGNQHDAEDLTQEVFVRVFRSLSTYTPGTFEGWLHRITTNLFLDMVRRKQRIRFDALGDDAAERLPSREPSPQQVFHDTHFDADVQQALDTLAPEFRAAVVLCDIEGLSYEEIAATLGVKLGTVRSRIHRGRSQLRKALQHRSPEARAERRSLAATGVPALGGGGTTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JN28</accession>
    <name>A0A2M9JN28_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Endopeptidase La</fullName>
            <ecNumber evidence="1">3.4.21.53</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CG723_30100</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CB01635</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of proteins in presence of ATP.</text>
            <dbReference type="EC" id="3.4.21.53"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S16 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.53" evidence="1"/>
    <dbReference type="EMBL" id="NNBL01000015">
        <property type="protein sequence ID" value="PJN08255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08255">
        <property type="protein sequence ID" value="PJN08255"/>
        <property type="gene ID" value="CG723_30100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004176">
        <property type="term" value="F:ATP-dependent peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030163">
        <property type="term" value="P:protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008269">
        <property type="entry name" value="Lon_proteolytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027065">
        <property type="entry name" value="Lon_Prtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10046">
        <property type="entry name" value="PTHR10046"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05362">
        <property type="entry name" value="Lon_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13180">
        <property type="entry name" value="PDZ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="SSF50156"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51786">
        <property type="entry name" value="LON_PROTEOLYTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0720">Serine protease</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014967904" description="Endopeptidase La" evidence="3">
        <location>
            <begin position="31"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="4">
        <location>
            <begin position="141"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="domain" description="Lon proteolytic" evidence="5">
        <location>
            <begin position="249"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="36"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="254"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PJN08255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="362" mass="38069" checksum="A201B1ED34A824A4" modified="2018-04-25" version="1">MPRRTATMLASTLMLIALLCAGVLIKVPYAEMTPGPTVNTLGDHDGEPVLQISGRKTYPTTGHLNMTTVRVTSADYNMNLVSAVYGWLAHDSIVVPHATLYPDGKTEQQSSQENAEEFSQSQESAKVAALDELKIPVKSWVIVQSVIKGSPSEGRLHAGDVIKAVDGTKVAKPADVAKLVTKHKPGEDVSFTIVPVKDAAAAEKEGKQPTRTQNVTVTTEKAKDGRAIVGIQAGTDHTFPFAIDIKLADVGGPSAGLMFALGIVDKLTPEDLTGGRFVAGTGTIDDDGKVGPIGGIQMKTVGARGKGARYFLTPKDNCAEAAKDVPGGLTLVKVNTIDDAMNALKDIRSGNTTDLPKCTVKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JN68</accession>
    <name>A0A2M9JN68_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_28320</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000014">
        <property type="protein sequence ID" value="PJN08304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08304">
        <property type="protein sequence ID" value="PJN08304"/>
        <property type="gene ID" value="CG723_28320"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014618168" evidence="1">
        <location>
            <begin position="28"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN08304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="91" mass="9230" checksum="FA9FCC146A3573AC" modified="2018-04-25" version="1">MISTRRVLAAVALAAGASALAMPAAQAAPVGPLGNMKPISLDDLTTSGIPAEHRAEIPTVNEQLGGLNRLNELHQVTDLVAPVTGLLPSVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-06-02" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JNG5</accession>
    <name>A0A2M9JNG5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_28935</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000014">
        <property type="protein sequence ID" value="PJN08406.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08406">
        <property type="protein sequence ID" value="PJN08406"/>
        <property type="gene ID" value="CG723_28935"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="136"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="15"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="148"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="167"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="232"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN08406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="304" mass="29054" checksum="0A6E5E8F2291DDF2" modified="2018-04-25" version="1">MCPGCGAYAPDIAPPATTSFSSRSSVSSQSASPASSSFFGVSPADDLGHRGGSAGAADSFDDFDAFSAAKAFDLDDTGGEAAAAAVDVSAPLAASRGGRAARRRKLAQWKKNKRRAVAATAVAIVGGGLTIAALPNDASPDRTHASAAPDPVTTSPALANTDSSTDTPDDRASRSGGDRAHKATGPRHARPANAPTPAATAAPTGAPRHAAPARSAAPHTTSAPAAAAHTAAPAPQTSSPAPAHQSGSGTSTGSGSGTGSGSGTGSGSGTGSGSSGGDQATTPAPAPSTASPEPICVLGLLCIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JNS4</accession>
    <name>A0A2M9JNS4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CG723_27445</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CB01635</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000013">
        <property type="protein sequence ID" value="PJN08518.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08518">
        <property type="protein sequence ID" value="PJN08518"/>
        <property type="gene ID" value="CG723_27445"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="38"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="98"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="134"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="159"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="220"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="259"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="99"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PJN08518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="291" mass="29744" checksum="3AA74DB210F76524" modified="2018-04-25" version="1">MTAPTPTPTPTATEALTPAGTQAPDTGPARTRPGRRTALLLLLPVVAVVLFALIGPWLAPHDPARITAAPYDTGHLLLGSDGDGRDVWSRFLAGGRPLVLIPLLATAVTTLLGTATGVLAGYAGGRVDAVVSRLDTLLLALPPVLVLLVLMHGWGYRTLTLVTAVAVTGVPFVSRVARAATAQVVHAGYVDQAVALGDGPVAVMAREIVPNIVRPVLADAGTRLAIAITLTASAGFLGFGPDSPNWGAMISENMEGVTLAPWGVAAPALGLAVLTVSVNLALDRAIARFVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JNU6</accession>
    <name>A0A2M9JNU6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Peptide synthetase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CG723_27590</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000013">
        <property type="protein sequence ID" value="PJN08543.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08543">
        <property type="protein sequence ID" value="PJN08543"/>
        <property type="gene ID" value="CG723_27590"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017000">
        <property type="term" value="P:antibiotic biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008610">
        <property type="term" value="P:lipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901362">
        <property type="term" value="P:organic cyclic compound biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030639">
        <property type="term" value="P:polyketide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001242">
        <property type="entry name" value="Condensatn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00668">
        <property type="entry name" value="Condensation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="SSF47336"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="4">
        <location>
            <begin position="467"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="3">
        <location>
            <position position="502"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PJN08543.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="551" mass="59703" checksum="4A891C819D9B456C" modified="2018-04-25" version="1">MTLTADDSLTVVTSFAQQSLWLQHQVDPDRAAYNITAAVRLRGPLDSAALERALNAVVARHEVLRTVFDLDGEDPVQVIRPDRELRVPVLDAGPDDFRRYADKVLFAPFDLRGGPLLRLELLRLGPEHHIALLALHHIVTDGASSAILLQELSHAYAAELAGVEPLWEELPIQYADFAVWQRDALSGAALDELTGHWTRTLAGAEPLALPADRERDADDSGHAAVHHFTLPAALTTRLEDLARAERATLFMVLLAGLDALLARYCGQEDITVVSPMAGRGRPELEGLIGYFVNPLLLRTQVSGTAGFAALVGRTRDTCLDAFDREELPFEQAVDVLRGHGGPGAEGLRSQVMLVLQNTRPSHWHSAGIDFELIPADTSTAKSDLVLEVRPDADGGCTAALEYRTGLYDAATADRVARHFAAILEAACERPDEPLSQLLATAVPDGEIPAVRGGAAHGEAPAATEYVAPRTPLEEEVAGIWSALLGTERVGVHDNFFDLGGQSLLAVRLAARLRDEFGVEMTVRDLYADFTLEAVTWAVLQRMTADEEQAPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JNU8</accession>
    <name>A0A2M9JNU8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Serine protease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CG723_28155</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CB01635</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000014">
        <property type="protein sequence ID" value="PJN08477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08477">
        <property type="protein sequence ID" value="PJN08477"/>
        <property type="gene ID" value="CG723_28155"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009403">
        <property type="term" value="P:toxin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003825">
        <property type="entry name" value="Colicin-V_CvpA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001940">
        <property type="entry name" value="Peptidase_S1C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02674">
        <property type="entry name" value="Colicin_V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00834">
        <property type="entry name" value="PROTEASES2C"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="SSF50494"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0645">Protease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="31"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="58"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="102"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PJN08477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="399" mass="42111" checksum="30B868A2F007AE9C" modified="2018-04-25" version="1">MNVLDILLLVAAVWFAIVGYRQGFVVGILSVIGFLGGGLVAVYVLPAIWSAVTDEAKVSTTAAVVAVIVVIVCASVGQAFTTHLGNKLRRYITWSPARALDATGGAVVNVVAMLLVAWLIGSALAGTTLPTLGKEVRNSKVLLGVSRALPTQANTWFADFSSALAQNGFPQVFSPFSNEPITDVQPPDPKLANSPVVQTAKRSIVKVTGQAPSCGKVLEGSGFVFADRRVMTNAHVVGGVDEPNVQIGGEGRMYAAKVVLYDWKRDIAVLDVPTLKAPPLQFTSTDAERGAGAIVAGFPENGAYDVRPARVRGRITANGPDIYHRGTVQRDVYSLYATVRQGNSGGPLLTPEGKVYGVVFAKSLDSAQTGYALTRDEISQDIDRGRTANQQVGSDNCAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JNY2</accession>
    <name>A0A2M9JNY2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Enoyl-CoA hydratase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CG723_27850</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000013">
        <property type="protein sequence ID" value="PJN08582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08582">
        <property type="protein sequence ID" value="PJN08582"/>
        <property type="gene ID" value="CG723_27850"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PJN08582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="223" mass="23990" checksum="5E5D7A222C8B9560" modified="2018-04-25" version="1">MPTLERQDDVFILDLGDGENRFHPDWIAAFDTALDEVEKAEGPRALVTVATGKFYSNGLDLDWLSAHAEQHQDYVVSVQRVFARLLSLPVITVAAVQGHAFAAGAMLTLAHDFRVMRTDRGFWCLPEVDINIPFTRGMAALIQARLAPQTAHEAMLTGGRYGGTDAAAAGIVDQAVAEDAVRTTAVELARTNAGKAGDTLATIKDRMYAPALAALRDTDSPLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JPC1</accession>
    <name>A0A2M9JPC1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_26995</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000012">
        <property type="protein sequence ID" value="PJN08733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08733">
        <property type="protein sequence ID" value="PJN08733"/>
        <property type="gene ID" value="CG723_26995"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN08733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="60" mass="6488" checksum="B73832BC2E976E06" modified="2018-04-25" version="1">MSTAPAPEPRDPKNALVFDDPLSTQSSDDTDRGWGERPTTGGDSAADLARFLDEKPPHHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JPZ0</accession>
    <name>A0A2M9JPZ0_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF4097 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_26000</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000011">
        <property type="protein sequence ID" value="PJN08938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08938">
        <property type="protein sequence ID" value="PJN08938"/>
        <property type="gene ID" value="CG723_26000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025164">
        <property type="entry name" value="DUF4097"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13349">
        <property type="entry name" value="DUF4097"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4097" evidence="2">
        <location>
            <begin position="123"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="264"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN08938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="301" mass="30757" checksum="17AA417DEAFFA5F6" modified="2018-04-25" version="1">MPEWSVAEPHKLAFDEPVTTLHVRIVNGTVNVVGTDEGSARLEVSGIEGPPLQVTLADGVLTVAYDDLPWKGFLKWLDRKGWRRSAIVSLAVPAGTGVEVGVVGAGAVVSGIQGRTEVRGVTGDTTLVGVAGDVRTDTVSGNLEAQAVTGDLRFNSVSGDLTVVEGAGPSVRAESVSGSMIVDLDPADRATDVNLTSVSGEIAIRLPHPADAEVEANTASGAVSNAFEDLRVGGHWGAKSITGRLGTGRGKLKATTVSGSIALLRRPPAEDYTQPPAEDSPATDAAATDAAAGGPADKKVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JR21</accession>
    <name>A0A2M9JR21_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ABC transporter substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_23495</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000009">
        <property type="protein sequence ID" value="PJN09313.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN09313">
        <property type="protein sequence ID" value="PJN09313"/>
        <property type="gene ID" value="CG723_23495"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042597">
        <property type="term" value="C:periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030678">
        <property type="entry name" value="Peptide/Ni-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039424">
        <property type="entry name" value="SBP_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000914">
        <property type="entry name" value="SBP_5_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30290">
        <property type="entry name" value="PTHR30290"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00496">
        <property type="entry name" value="SBP_bac_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002741">
        <property type="entry name" value="MppA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014624603" evidence="1">
        <location>
            <begin position="31"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="domain" description="SBP_bac_5" evidence="2">
        <location>
            <begin position="77"/>
            <end position="419"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN09313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="512" mass="54875" checksum="4C985757173B4689" modified="2018-04-25" version="1">MRISARIGALTAGATALSLVLTGCGTDGGSATAGTAELDIATLTNTQSLDPATALGSALPYFQAVYDTLIKRAPDGTYKPMLATKWTYDKSRTQLSLTLRQGVKFSDGTAFDAQAVKANLEHFKGGGGGGAKYLAALKNVKVADATHVTLELTSPDPGMLFYLSDAAGLMASPKKLAGGSLKTKPVGTGPYTLDKAKTAIGSKYVFDRKKDYWGEELPYKTLTISVFDNETAVVNGLKTGQLDSAVLQDANQQASIEPDTNLTKSKHSFDFQGLLLFDRGGVRTPQLKDARVRQALNYALDRETMLEKIRGGRGEITDQVFGPETKAYDKSLDSYYPHDPAKAKKLLAQAGYAQGFTLKLPRMSAIVNDALASSIEADFKAVGVKVKWDQLDGATALQKIFREKAYSGMVMNIGQSSIDWVTMNDLVVPGAFNPFATSDPTVKKLLPQVQVASGTKAGDDASRALNKHLVEEGWFAPFYRASFLLVSSKDVKVVPQSGMAVPSIYNYTPAKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JR79</accession>
    <name>A0A2M9JR79_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_23765</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000009">
        <property type="protein sequence ID" value="PJN09352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN09352">
        <property type="protein sequence ID" value="PJN09352"/>
        <property type="gene ID" value="CG723_23765"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="88"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="93"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN09352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="107" mass="11688" checksum="E637A1B840D97067" modified="2018-04-25" version="1">MPAAASATSLAEKFERRLKVQRDSGEAPDPRAAQIERLKAENAELRTRITAKDEAVAKLKAFRIQAVSQLTAQHEVITRLRSQVAEAGNVRRMPNTGSRTAPFGSCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JRC4</accession>
    <name>A0A2M9JRC4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glyoxalase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_23730</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000009">
        <property type="protein sequence ID" value="PJN09347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN09347">
        <property type="protein sequence ID" value="PJN09347"/>
        <property type="gene ID" value="CG723_23730"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004360">
        <property type="entry name" value="Glyas_Fos-R_dOase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00903">
        <property type="entry name" value="Glyoxalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VOC" evidence="1">
        <location>
            <begin position="4"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN09347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="156" mass="17102" checksum="92D1B978B53147AC" modified="2018-04-25" version="1">MNLKLEMIVLPVSDVDRAKAFYEKVGFRLDVDYTANEDVRVVHFTPPGSECSISFGEGMTPIAPGSFQGLYLIVSDIEEARAELVGRGIEVSEIFHDAGGLFHGHEDGDVTHRGPGQERLAGLHPERASYGSFLTFSDPDGNGWVLQEVTQRLPGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JRP8</accession>
    <name>A0A2M9JRP8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CG723_22490</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CB01635</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000008">
        <property type="protein sequence ID" value="PJN09518.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN09518">
        <property type="protein sequence ID" value="PJN09518"/>
        <property type="gene ID" value="CG723_22490"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039428">
        <property type="entry name" value="NUOK/Mnh_C1-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00420">
        <property type="entry name" value="Oxidored_q2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="30"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="72"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PJN09518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="115" mass="11995" checksum="F4C75D6A206932F9" modified="2018-04-25" version="1">MSVLPYLAAGWIFLVGCYGLATSRNLIHAVGCLSVCQSSTYVLLLAVGYRRGGTAPVFSDITPGSRPVVDPVVQALALTDVVVGATVTALLLALVIQTAKRHGTVDPDELSELRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-09-29" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JRX3</accession>
    <name>A0A2M9JRX3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CG723_22250</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CB01635</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000008">
        <property type="protein sequence ID" value="PJN09626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN09626">
        <property type="protein sequence ID" value="PJN09626"/>
        <property type="gene ID" value="CG723_22250"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="51"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="77"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="122"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="146"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="201"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="234"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="262"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="287"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="324"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="353"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="1"/>
            <end position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PJN09626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="393" mass="41166" checksum="A0A4AADECE4C41BB" modified="2018-04-25" version="1">MLANTLFQRGVFVLFLQQRGFSAGQVALLQTLLYLVSGLAELPTGVIADRIGRRASIVIGQMLIAGCLLGQGTFSNYWVFLALFVGQGVGMACVSGSDTALLYDLLVRRGATANYVKIKSRFTMLGTVTSGAAIVLGGQLQQISWGVVYVGSAACLVLAVVVLMSRVPEIRGADAVDEQDGAEEHGDATAWRAMLRVATPALVTLVVVSGLMHATLTPYIIFTQKTLSDQGAGTALVSVVISAGFFTGGLTPLVSDRADRRIGYRVIVPVSLLALAVALGLSGLGLVWVTIAAFLILVGIPEITAVIVDNVFNEAVPSRHRASLLSMIAFVESALIGIGYLVLGALMDGLGSGVGMATYAAVPLLACLLWLPVLFRGARVTTEIEKPADQKAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JS68</accession>
    <name>A0A2M9JS68_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Thiamine-monophosphate kinase</fullName>
            <shortName evidence="2">TMP kinase</shortName>
            <shortName evidence="2">Thiamine-phosphate kinase</shortName>
            <ecNumber evidence="2">2.7.4.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">thiL</name>
        <name evidence="5" type="ORF">CG723_21080</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CB01635</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the ATP-dependent phosphorylation of thiamine-monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>ATP + thiamine phosphate = ADP + thiamine diphosphate</text>
            <dbReference type="Rhea" id="RHEA:15913"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:37575"/>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.16"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Cofactor biosynthesis; thiamine diphosphate biosynthesis; thiamine diphosphate from thiamine phosphate: step 1/1.</text>
    </comment>
    <comment type="miscellaneous">
        <text evidence="2">Reaction mechanism of ThiL seems to utilize a direct, inline transfer of the gamma-phosphate of ATP to TMP rather than a phosphorylated enzyme intermediate.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the thiamine-monophosphate kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.16" evidence="2"/>
    <dbReference type="EMBL" id="NNBL01000007">
        <property type="protein sequence ID" value="PJN09698.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN09698">
        <property type="protein sequence ID" value="PJN09698"/>
        <property type="gene ID" value="CG723_21080"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00060">
        <property type="reaction ID" value="UER00142"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009030">
        <property type="term" value="F:thiamine-phosphate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009228">
        <property type="term" value="P:thiamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009229">
        <property type="term" value="P:thiamine diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02194">
        <property type="entry name" value="ThiL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.650.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02128">
        <property type="entry name" value="TMP_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010918">
        <property type="entry name" value="PurM-like_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036676">
        <property type="entry name" value="PurM-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016188">
        <property type="entry name" value="PurM-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036921">
        <property type="entry name" value="PurM-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006283">
        <property type="entry name" value="ThiL"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30270">
        <property type="entry name" value="PTHR30270"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00586">
        <property type="entry name" value="AIRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02769">
        <property type="entry name" value="AIRS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005303">
        <property type="entry name" value="Thiam_monoph_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55326">
        <property type="entry name" value="SSF55326"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56042">
        <property type="entry name" value="SSF56042"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01379">
        <property type="entry name" value="thiL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 5" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0784">Thiamine biosynthesis</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="AIRS" evidence="3">
        <location>
            <begin position="33"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="domain" description="AIRS_C" evidence="4">
        <location>
            <begin position="156"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="34"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="48"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>4</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="49"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="50"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="57"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="79"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="126"/>
            <end position="127"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="127"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="152"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="214"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="216"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="217"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>5</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="267"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="313"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PJN09698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="321" mass="33516" checksum="224CA8442523212D" modified="2018-04-25" version="1">MKGTVGELGEFGLIRELTSRLTTTPAVRLGPGDDAAVVAAPDRRVVVSTDILLEGRHFRRDWSTAYDVGRKAAAQNLADIAAMGAVPTALLLGLVVPAELPASWPNELMDGLRDECQVAGAAVVGGDVVRGDTITVAITALGDMRNHEPVTRAGAQPGDVVAVTGWLGWSAAGHAVLSRGFRSPRAFVEAHRRPEPPYHAGPAAAGLGATAMCDVSDGLIADLGHIAEASKVRIDIKSGKVDVPSQMNDIGQAVGVDPIQWVLTGGEDHAIVATFPPDVKLPARWKVIGEVLNPSALPQVTVDGAPWTNKGGWDHFGDIEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JSC1</accession>
    <name>A0A2M9JSC1_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">1-deoxy-D-xylulose 5-phosphate reductoisomerase</fullName>
            <shortName evidence="7">DXP reductoisomerase</shortName>
            <ecNumber evidence="7">1.1.1.267</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">1-deoxyxylulose-5-phosphate reductoisomerase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">2-C-methyl-D-erythritol 4-phosphate synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">dxr</name>
        <name evidence="11" type="ORF">CG723_21560</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CB01635</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>2-C-methyl-D-erythritol 4-phosphate + NADP(+) = 1-deoxy-D-xylulose 5-phosphate + H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:13717"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:57792"/>
            <dbReference type="ChEBI" id="CHEBI:58262"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.267"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="1 7">Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via DXP pathway; isopentenyl diphosphate from 1-deoxy-D-xylulose 5-phosphate: step 1/6.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the DXR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.267" evidence="7"/>
    <dbReference type="EMBL" id="NNBL01000007">
        <property type="protein sequence ID" value="PJN09785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN09785">
        <property type="protein sequence ID" value="PJN09785"/>
        <property type="gene ID" value="CG723_21560"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00056">
        <property type="reaction ID" value="UER00092"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030604">
        <property type="term" value="F:1-deoxy-D-xylulose-5-phosphate reductoisomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070402">
        <property type="term" value="F:NADPH binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019288">
        <property type="term" value="P:isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016114">
        <property type="term" value="P:terpenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00183">
        <property type="entry name" value="DXP_reductoisom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003821">
        <property type="entry name" value="DXP_reductoisomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013644">
        <property type="entry name" value="DXP_reductoisomerase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013512">
        <property type="entry name" value="DXP_reductoisomerase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026877">
        <property type="entry name" value="DXPR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036169">
        <property type="entry name" value="DXPR_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30525">
        <property type="entry name" value="PTHR30525"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08436">
        <property type="entry name" value="DXP_redisom_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02670">
        <property type="entry name" value="DXP_reductoisom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13288">
        <property type="entry name" value="DXPR_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006205">
        <property type="entry name" value="Dxp_reductismrs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69055">
        <property type="entry name" value="SSF69055"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00243">
        <property type="entry name" value="Dxr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6 7" id="KW-0414">Isoprene biosynthesis</keyword>
    <keyword evidence="3 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 7" id="KW-0521">NADP</keyword>
    <keyword evidence="5 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DXP_reductoisom" evidence="8">
        <location>
            <begin position="26"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="domain" description="DXP_redisom_C" evidence="9">
        <location>
            <begin position="170"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="domain" description="DXPR_C" evidence="10">
        <location>
            <begin position="287"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="29"/>
            <end position="58"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="151"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="174"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="176"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="200"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="223"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF08436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF13288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PJN09785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="424" mass="44066" checksum="D014E4A92259150B" modified="2018-04-25" version="1">MSDSASPLADPHLVYDPAGTDGPRDVVILGSTGSIGTQAIDLVLRNPDRFTVTALSAAGGRVGLLAEQARQLRVRTVAVAREDVVPALREALSAQYADGEPLPEILAGPDAATQLAASPCHTVLNGITGSIGLAPTLAALEAGRTLALANKESLIVGGPLVKALAKPGQIIPVDSEHAALFQALAAGKRADVRKLVVTASGGPFRGRTKADLAHVTPEDALAHPTWAMGPVITVNSATLVNKGLEVIEAHLLYDIPFERIEVVVHPQSYVHSMVEFTDGSTLAQATPPDMRGPIAIGLGWPERIPDAAPAFDWTKASSWEFFPLDTEAFPSVGLARHVGKLAGTAPAVFNAANEECVDAFLNGALPFNGIMDTVTKVVEEHGAPSAAAAGTSLTVADVLEAETWARARTRELTAQATSTAEARA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JSI9</accession>
    <name>A0A2M9JSI9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Topoisomerase II</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_21705</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000007">
        <property type="protein sequence ID" value="PJN09812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN09812">
        <property type="protein sequence ID" value="PJN09812"/>
        <property type="gene ID" value="CG723_21705"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025669">
        <property type="entry name" value="AAA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13614">
        <property type="entry name" value="AAA_31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA_31" evidence="2">
        <location>
            <begin position="596"/>
            <end position="745"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="122"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="550"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="839"/>
            <end position="981"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="40"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="56"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="213"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="244"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="266"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="299"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="406"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="852"/>
            <end position="912"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="913"/>
            <end position="927"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="928"/>
            <end position="981"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN09812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="981" mass="100754" checksum="AF715A0861043138" modified="2018-04-25" version="1">MNSDRDEIRGGWDTPVDDHSDAESATETTGEFTIDYAPPAWYTQNASSGTGETPSATPATPPPPVPPAPAPTPAPAPQAPPAPYTPYTPAASAAEPDAGSGNGDLESGATMRFSAAALKREFAELAAQGEQKAEPTSGPTTEEQGGDAASADAQAGADGENSDSGESGDFAVVAAAGPSGDAADDGDTDANAHTDAAQASTDDTDSEAASDDASEAEGSTGSDDSGDTGSETAGAAPTAAPADASADTGTSVGSDASADAQNAPAAWAPPPVPQEGIPPLPPAFQPAAPTSAPQWPAQQQPQPGAPVPAQGAPAPPAWPAQNTPPAPQGGYGFPQQAAPGDPQQPAPPAQQQGYGFPQQTPPAAGAPNQPAPQGGYGFPQQPQPGTPNQPAPQGGYGFPQQPQPGAGYGFPQPQPGAPAQGHPAAPNSPAPPAPHLPAQQHPQQPPAPHTQQPGPQPPVGQQPHPQPPAPQAPAPHPEGRPGHPGQPQPDQQFQGQPGQPFPGQVPPADPRAGGAWPQPIQHDQRTPTNVGGAPLGYTAAVELSADRLLSNKRQKAKSTRPGGANSRFKLGGKKEEAERQRKLDLIRTPVLSCYRIAVISLKGGVGKTTTTTALGSTLATERQDKILAIDANPDAGTLGRRVRRETGATIRDLVQAIPHLNSYMDIRRFTSQAPSGLEIIANDVDPAVSTTFNDTDYRSAIDVLGKQYPIILTDSGTGLLYSAMRGVLDLADQLIIISTPSVDGASSASTTLDWLSAHGYADLVSRSITVISGVRETGKMIKVDDIVSHFETRCRGVVVVPFDEHLAAGAEVDLDMMRPKVREAYFNLSAMVAEDFPRAQQQQGLWTSDGNPPPTMAPPVPGHQQQPYPAQQPYPGQPYPGQPGTPQPPAPGQQPAPGQQFPGQPYPGQPYPQQPGQAQAGAPGQPQQPGQPSRPGPPQMWQQQPPAPAQPGQPAPGQPPAPGQPGQPLPPYTAQPQPPQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JSL5</accession>
    <name>A0A2M9JSL5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CG723_21515</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000007">
        <property type="protein sequence ID" value="PJN09777.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN09777">
        <property type="protein sequence ID" value="PJN09777"/>
        <property type="gene ID" value="CG723_21515"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PJN09777.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="155" mass="16464" checksum="719B628F8C3DB295" modified="2018-04-25" version="1">MTGSGAKSAVEWLASVAPDPDACRWEWERNPLGVALLPAGRLWDVLILPGELGYPTLDVLTRVIDRPGPVLADFGDARMGFFVPSGTATRWLGTGVRGAGRGTWIVVPHPLPGRAAGGVRWLIPPDGSGTLTDPTVLELAMHEAAAQLARDDIHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JSU9</accession>
    <name>A0A2M9JSU9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Succinate dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CG723_19525</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000006">
        <property type="protein sequence ID" value="PJN09928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN09928">
        <property type="protein sequence ID" value="PJN09928"/>
        <property type="gene ID" value="CG723_19525"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016627">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1300.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034804">
        <property type="entry name" value="SQR/QFR_C/D"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000701">
        <property type="entry name" value="SuccDH_FuR_B_TM-su"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01127">
        <property type="entry name" value="Sdh_cyt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81343">
        <property type="entry name" value="SSF81343"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0349">Heme</keyword>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="53"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="98"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="138"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PJN09928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="162" mass="17872" checksum="E014C60A6B16A3F4" modified="2018-04-25" version="1">MSADTTPAKTPGVGPVEGVAVYDVDNPAPFIEAPRKRTSKTPRSTRGNFEMAAWLFMRLSGVVLVVLVLGHLLIQLVLDGGVSKIGFAFVAGRWASPFWQGWDLLMLWLAMLHGANGLRTVINDYAERPNTRLWLKGLLYTATVFTILLGTLVIFTFDPNIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JSW1</accession>
    <name>A0A2M9JSW1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Peptidase M23</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_19845</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000006">
        <property type="protein sequence ID" value="PJN09981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN09981">
        <property type="protein sequence ID" value="PJN09981"/>
        <property type="gene ID" value="CG723_19845"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.70.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011055">
        <property type="entry name" value="Dup_hybrid_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016047">
        <property type="entry name" value="Peptidase_M23"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01551">
        <property type="entry name" value="Peptidase_M23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51261">
        <property type="entry name" value="SSF51261"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase_M23" evidence="2">
        <location>
            <begin position="443"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="118"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="239"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="339"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="247"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN09981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="548" mass="58271" checksum="5FB7D2F72B6ED105" modified="2018-04-25" version="1">MNDRHPSGTQTSPAPAQDADYAPYAPYDQQSAHYGDYTGYDGYATGGFAADPLFGDLPGAQNTGSYDSGQWATGAHQTLTTQDPQHHDPYAAQQHASAYGTGSYDTTAVWGTAAHEQLGGIPAQSGPDHSGQWDNSAWADQTGQWDANAFGAQAQGFTTQDAFATQAFQAPAAFETGTYETGTFDAQGFETQAFEAQAYETQAFEAQAYETQAFEAQPFATQTFEAQTFDTDAYDATAWNSAGTEGDDNDLDARHDYGQPDASEPESSHNDDRHDSYSEGLDDVEEIVARDERPAPVTPAQRARSRRRSPAKRSALLTVAVPSVCVMGVAGVAAASVGGLGGDDSKDTTAASAPDATAVKPSVANNKLDTQLADLSADAGDFADRASRTQERIDLRAKQQAERKQAAEEAARKERLRPKFVLPVKQRGLSAYFGQAGINWMSVHTGIDFPVSYGTPVMAATDGTVRTQWNSAYGNMTILTAKDGTETWYCHLSSHAVMSGPVKAGDLIAHSGNSGNSTGPHLHFEVRPGGGSAVDPLPWLRSHGLDPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JSW3</accession>
    <name>A0A2M9JSW3_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">VWFA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_19810</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000006">
        <property type="protein sequence ID" value="PJN09974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN09974">
        <property type="protein sequence ID" value="PJN09974"/>
        <property type="gene ID" value="CG723_19810"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008912">
        <property type="entry name" value="Uncharacterised_CoxE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05762">
        <property type="entry name" value="VWA_CoxE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00327">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="SSF53300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VWFA" evidence="1">
        <location>
            <begin position="219"/>
            <end position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00327"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN09974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="399" mass="42557" checksum="A1B639F0AF9F1FF3" modified="2018-04-25" version="1">MAVDQVDELSGGARGERMRRWRLVLGGDEADGTGCALGGQDAAMDGALTALYGGGGKAERGRHRSAGLGASAPSVARWLGDIRTYFPSSVVQVMQRDAIDRLGLSALLLEPEMLEAVDADVHLVGTLLSLNKAMPETTKETARAVVRKVVEDLEKRLVTRTRATLTGALDRSARINRPRHHDIDWNRTIAANLKNYLPEYRTVVPERLIGYGRASQSVKKEVILCIDQSGSMAASVVYASVFGAVLASMRSINTRLVVFDTAVVDLTDQLDDPVDVLFGTQLGGGTDINRALAYCQSQITRPAETVVVLISDLYEGGIRNEMLKRVAAMKSSGVQFVTLLALSDEGAPAYDREHAAALAASGAPAFACTPDLFPEVMAAAIEKRPLPIPDSGNPANGAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JTC0</accession>
    <name>A0A2M9JTC0_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Bifunctional NAD(P)H-hydrate repair enzyme</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Nicotinamide nucleotide repair protein</fullName>
        </alternativeName>
        <domain>
            <recommendedName>
                <fullName evidence="11">ADP-dependent (S)-NAD(P)H-hydrate dehydratase</fullName>
                <ecNumber evidence="11">4.2.1.136</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="11">ADP-dependent NAD(P)HX dehydratase</fullName>
            </alternativeName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="11">NAD(P)H-hydrate epimerase</fullName>
                <ecNumber evidence="11">5.1.99.6</ecNumber>
            </recommendedName>
        </domain>
    </protein>
    <gene>
        <name evidence="10" type="primary">nnrE</name>
        <name evidence="9" type="synonym">nnrD</name>
        <name evidence="13" type="ORF">CG723_20125</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">CB01635</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8 11">Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.</text>
    </comment>
    <comment type="function">
        <text evidence="9">Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.</text>
    </comment>
    <comment type="function">
        <text evidence="10">Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow the repair of both epimers of NAD(P)HX.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10 11">
            <text>(6R)-NADHX = (6S)-NADHX</text>
            <dbReference type="Rhea" id="RHEA:32215"/>
            <dbReference type="ChEBI" id="CHEBI:64074"/>
            <dbReference type="ChEBI" id="CHEBI:64075"/>
            <dbReference type="EC" id="5.1.99.6"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 10 11">
            <text>(6R)-NADPHX = (6S)-NADPHX</text>
            <dbReference type="Rhea" id="RHEA:32227"/>
            <dbReference type="ChEBI" id="CHEBI:64076"/>
            <dbReference type="ChEBI" id="CHEBI:64077"/>
            <dbReference type="EC" id="5.1.99.6"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3 9 11">
            <text>(6S)-NADHX + ADP = AMP + H(+) + NADH + phosphate</text>
            <dbReference type="Rhea" id="RHEA:32223"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:64074"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="4.2.1.136"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4 9 11">
            <text>(6S)-NADPHX + ADP = AMP + H(+) + NADPH + phosphate</text>
            <dbReference type="Rhea" id="RHEA:32235"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:64076"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="4.2.1.136"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10 11">
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </cofactor>
        <text evidence="10 11">Binds 1 potassium ion per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="9">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the NnrD/CARKD family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the NnrE/AIBP family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6 11">In the C-terminal section; belongs to the NnrD/CARKD family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5 11">In the N-terminal section; belongs to the NnrE/AIBP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.136" evidence="11"/>
    <dbReference type="EC" id="5.1.99.6" evidence="11"/>
    <dbReference type="EMBL" id="NNBL01000006">
        <property type="protein sequence ID" value="PJN10027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN10027">
        <property type="protein sequence ID" value="PJN10027"/>
        <property type="gene ID" value="CG723_20125"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052855">
        <property type="term" value="F:ADP-dependent NAD(P)H-hydrate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052856">
        <property type="term" value="F:NADHX epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052857">
        <property type="term" value="F:NADPHX epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046496">
        <property type="term" value="P:nicotinamide nucleotide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01171">
        <property type="entry name" value="YXKO-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10260">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01965">
        <property type="entry name" value="NADHX_dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01966">
        <property type="entry name" value="NADHX_epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000631">
        <property type="entry name" value="CARKD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030677">
        <property type="entry name" value="Nnr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004443">
        <property type="entry name" value="YjeF_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036652">
        <property type="entry name" value="YjeF_N_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01256">
        <property type="entry name" value="Carb_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03853">
        <property type="entry name" value="YjeF_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017184">
        <property type="entry name" value="Nnr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="SSF53613"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64153">
        <property type="entry name" value="SSF64153"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00196">
        <property type="entry name" value="yjeF_cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00197">
        <property type="entry name" value="yjeF_nterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51383">
        <property type="entry name" value="YJEF_C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51385">
        <property type="entry name" value="YJEF_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 10 11" id="KW-0413">Isomerase</keyword>
    <keyword evidence="9 11" id="KW-0456">Lyase</keyword>
    <keyword evidence="10 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 11" id="KW-0520">NAD</keyword>
    <keyword evidence="9 11" id="KW-0521">NADP</keyword>
    <keyword evidence="9 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10 11" id="KW-0630">Potassium</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YjeF N-terminal" evidence="12">
        <location>
            <begin position="10"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="NADPHX" evidence="10">
        <location>
            <begin position="58"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="NADPHX" evidence="10">
        <location>
            <begin position="122"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="59"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="118"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="151"/>
        </location>
        <ligand>
            <name>(6S)-NADPHX</name>
            <dbReference type="ChEBI" id="CHEBI:64076"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="154"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="250"/>
        </location>
        <ligand>
            <name>(6S)-NADPHX</name>
            <dbReference type="ChEBI" id="CHEBI:64076"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="304"/>
        </location>
        <ligand>
            <name>(6S)-NADPHX</name>
            <dbReference type="ChEBI" id="CHEBI:64076"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="349"/>
        </location>
        <ligand>
            <name>(6S)-NADPHX</name>
            <dbReference type="ChEBI" id="CHEBI:64076"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="386"/>
            <end position="390"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="422"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="423"/>
        </location>
        <ligand>
            <name>(6S)-NADPHX</name>
            <dbReference type="ChEBI" id="CHEBI:64076"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00000909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00001241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00006001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00009524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00025153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR017184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PJN10027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="483" mass="47856" checksum="631ABB2256DED768" modified="2018-04-25" version="1">MRTAYSVDTVRTAERALMARLPEGALMQRAAAGLAVVCAELLGKVYGARVVLLVGSGDNGGDALYAGARLARRGAGVAAVLLDSERVHRAGLAAFLSAGGRVADSFERVLAGADLVVDGIVGIGGRGGLRAGALPVVRAALDSRAVVVSVDLPSGVDADTGQVDGEAVRADVTVTFGAYKPGLLVDPGREYAGAVRLVDIGLEPVPGEGDLEALQHDDVARLLPEPTGESDKYRRGVVGIVAGSARYPGAAVLAVAGALRGGAGAVRYVGPAAGAVVSRFPETLVSEGAPGKAGRVQAWVAGPGLGDDASRLADVVGADVPVLIDADGLRLADPEAVRGRGAPTLLTPHAGEAAALLGVSREEVEAERLAAVRELASRFSATVLLKGSTTLVAGGGGSAGGEGRLVRVNSTGTAWLATAGSGDVLSGLAGSLLAAGLGALDAGSVGAYLHGLAARRVSGGAPVVAQDVAGGIAGAWGDVRRGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JTE1</accession>
    <name>A0A2M9JTE1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">30S ribosomal protein S8</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CG723_20260</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000006">
        <property type="protein sequence ID" value="PJN10156.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN10156">
        <property type="protein sequence ID" value="PJN10156"/>
        <property type="gene ID" value="CG723_20260"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="1" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PJN10156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="54" mass="5871" checksum="6B9AA053A810EC64" modified="2018-04-25" version="1">MVCRVRVTQTSQHVRDRISHGHEVAFGLSRRGFLYAPSLSPHRGGTGAVRGPTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JTE4</accession>
    <name>A0A2M9JTE4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CG723_20620</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000006">
        <property type="protein sequence ID" value="PJN10108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN10108">
        <property type="protein sequence ID" value="PJN10108"/>
        <property type="gene ID" value="CG723_20620"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PJN10108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="66" mass="7761" checksum="21F26AC6275F18A3" modified="2018-04-25" version="1">MVHNEHSRDIVQAQRDWIRTYNALAEAPTGSNTRLRRRLIDLSRRLVQGVPREQLADLRQQAEEKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JTE9</accession>
    <name>A0A2M9JTE9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Stress protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_17335</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000005">
        <property type="protein sequence ID" value="PJN10171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN10171">
        <property type="protein sequence ID" value="PJN10171"/>
        <property type="gene ID" value="CG723_17335"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06974">
        <property type="entry name" value="TerD_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003325">
        <property type="entry name" value="TerD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02342">
        <property type="entry name" value="TerD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TerD" evidence="1">
        <location>
            <begin position="14"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN10171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="195" mass="20575" checksum="776CA409757D0B42" modified="2018-04-25" version="1">MITLTKEDGPADLDGVTHLSIGVSWDPTAGSSGGLMGKLRRNVGTDLDLIAVALQGADPVRLAGLDSLDPLGNGSLVHSGDNQTGRGDGDDETVTVEFGRVPANITSIVFVAAAYKKSSSFTKARNISFKVYDATGGTSQQVADIWPSLLTNDNGCRVAKAIRVNGSWKLEVLNETGKIKQGDERALMRFAVSNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JTU3</accession>
    <name>A0A2M9JTU3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Amino acid permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CG723_18145</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CB01635</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000005">
        <property type="protein sequence ID" value="PJN10306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN10306">
        <property type="protein sequence ID" value="PJN10306"/>
        <property type="gene ID" value="CG723_18145"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="40"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="67"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="110"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="158"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="191"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="220"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="261"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="315"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="365"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="390"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="422"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="447"/>
            <end position="465"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PJN10306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="491" mass="50971" checksum="84E0C6F1E61AFAB0" modified="2018-04-25" version="1">MRVTARQLCRRKPLESMIGEAEGEASGPGGLRRSMGLTQLTLLGISSVVGTGIFFVLGTAVPKAGPGVVLSFVVAAVVAGLAALCYVELAGAIPVAGSTYSYTYASLGEGVAYLVAWCLILEYGVAVSTVAVSWGQYLNELTDALFGFTLPDAISQPPGAGGVVNVPALVVVLLCSLLLARGTRESARLNAVMVCVKLSVLVLFVAVAFTAFRAGHFADFAPHGASGIGVAASAVFFSYVGFDTVATASEEVRNPRRTIPLALLLTLGAVTVLYILVSLAAVGAQPAGRFGAQADAGEAVLAEILRDVTGAGWPVVLLSAGAVVSIFSVVLVTLYGQTRILFSMARDGLVPEVFRRVDRKRHTPVGNTWIVGAGVGALAAFVPLQYLADLTSMGTLVAFVAVAAAVIVLRRIAPDAPRPYKVPLYPVVPIVSAASCLYLAWLLPGVTWVLFGVWLVLAAVLYLTFGRRHSALRGRGAPAEEAIVTTTSAQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JTU8</accession>
    <name>A0A2M9JTU8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">XRE family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_18175</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000005">
        <property type="protein sequence ID" value="PJN10310.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN10310">
        <property type="protein sequence ID" value="PJN10310"/>
        <property type="gene ID" value="CG723_18175"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013096">
        <property type="entry name" value="Cupin_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07883">
        <property type="entry name" value="Cupin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01381">
        <property type="entry name" value="HTH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="2">
        <location>
            <begin position="39"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN10310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="215" mass="23613" checksum="6BE34EE7AF282C19" modified="2018-04-25" version="1">MDDVDDVGDVGDIDDVDDVDDVDKPAPYQAVLDEVAPRLRRLRDRRGLTLAALSEVTGISKSTLSRLESGHRRPSLELLLPLAGAYGVPLDELVGAPEVGDPRVRLTPRPMPSGGTFVPLTRSPGPLQAYKMVIADRGCEPDLRTHEGYEWLYVLDGRLRLVLAEHDLVLGPGEAAEFDTRVPHWFSSADGRPVELLSLFGRQGERMHVRAKPHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JU90</accession>
    <name>A0A2M9JU90_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF5709 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_19005</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000005">
        <property type="protein sequence ID" value="PJN10444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN10444">
        <property type="protein sequence ID" value="PJN10444"/>
        <property type="gene ID" value="CG723_19005"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043763">
        <property type="entry name" value="DUF5709"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18970">
        <property type="entry name" value="DUF5709"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF5709" evidence="2">
        <location>
            <begin position="115"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="93"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="93"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="114"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF18970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN10444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="175" mass="18841" checksum="6BAE86A42912050B" modified="2018-04-25" version="1">METEATAEGGDVDIDDQGRGDDVYQPDGSEVQDDEGLLDQEDTLLGGGVTDPLDQGYSPPERPWGVEHTGVTCTEQRLGETLDERLSEEVPDLVVPDDDGIGDTWDTDGESLDDEVGAERSGRLVSPDEGVRKNEEGELFAEDVGIDGAAASAEEAAMHLVEDVRRGRDPRRVTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-09-29" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JUG2</accession>
    <name>A0A2M9JUG2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CG723_19100</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000005">
        <property type="protein sequence ID" value="PJN10462.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN10462">
        <property type="protein sequence ID" value="PJN10462"/>
        <property type="gene ID" value="CG723_19100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PJN10462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="499" mass="54770" checksum="FC51A17813A38DAE" modified="2018-04-25" version="1">MNGQPNTRLNDLFGLAGWSKGELARLVNRQAAAMGHPQLSTDTSRVRRWIDMGEIPRDPVPRVLAALFTERLGRVVTIEDLGLVRHGRTGKRRDDGAVQHPDGMPWAPERTAAVLTEFTGMDLMLNRRGLVGAGAALATGSVLSGAMHDWLHTDPALAADAPRFEDPLHADPAGFDRYEAAPIGSQEIEELERSVEVFRAWDAARGGGLQRKAVVGQLNEVGGMLSYRHPDHLQRRLWGVAANLAVLAGWMSHDVGLEPTAQKYFVIAAHAAREGGDRPRAGEALSRAARQMVHLGRPDDALDLMKLAKSGSGDQTLPRTRAMLYTIEAWAQASMGKGQAMRRTLGQAEDLFVSDKGDVPPPSWMQMFDEADLHGMQALAYRTLADHEPAAANTAQRHAKEALELRANGRQRSQIFDYISLASALFIADDPEQADRYARLALVSMGANSSHRTWDRLREMYRLTGQYATYPKIVDLREEIKLALPKTPGKPTGGKRAQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JUQ8</accession>
    <name>A0A2M9JUQ8_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNAse_A_bac domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_15520</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000004">
        <property type="protein sequence ID" value="PJN10621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN10621">
        <property type="protein sequence ID" value="PJN10621"/>
        <property type="gene ID" value="CG723_15520"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041436">
        <property type="entry name" value="RNAse_A_bac"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18431">
        <property type="entry name" value="RNAse_A_bac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNAse_A_bac" evidence="1">
        <location>
            <begin position="6"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF18431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN10621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="101" mass="11488" checksum="65F5D72B74A5953E" modified="2018-04-25" version="1">MPTRIRSSTYPDRETAQWATQQVVTANEQLVHRWLAQSTRPRLTVEAAWPSRQDPVGRVLLQAMMLAGRDPVDVRAARVILRRDDASPHGFVVHATFPVYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JUZ2</accession>
    <name>A0A2M9JUZ2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CG723_15950</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CB01635</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000004">
        <property type="protein sequence ID" value="PJN10693.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN10693">
        <property type="protein sequence ID" value="PJN10693"/>
        <property type="gene ID" value="CG723_15950"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="54"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="119"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="152"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="254"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="316"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="115"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PJN10693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="343" mass="37722" checksum="CA6E1E60D41210C7" modified="2018-04-25" version="1">MTSSDEALAQSATSADTAPGSQEPGAARGAQGRGTAPTGAGAWRSRLYRWDMKASPYAFISPFFIIFGAFSMVPLLYTAWYSLHHVQLSNLDGQTWAGLDNYTNLFQSDFFWNALKNTFTIGVISTVPQLIAAIWLAHMLNYRLRGSTVWRVVMLTPYATSVAAATLVFVLLFSPDTGMINWALDLVGIDPVNWRESDWGSQAAVSSIVIWRWTGYNALIYLAAMQAIPADLYESAALDGANRWQQFRHVTIPMLRPTILFTVVVSTIGATQLFGEPLLFGGVSGTKGGSEHQYQTLGLYMYDQGWIVGNLGKASAIAWSMFLILLIVAAVNLLITRRLRKSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JV44</accession>
    <name>A0A2M9JV44_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">PrsW family intramembrane metalloprotease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_16240</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000004">
        <property type="protein sequence ID" value="PJN10739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN10739">
        <property type="protein sequence ID" value="PJN10739"/>
        <property type="gene ID" value="CG723_16240"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026898">
        <property type="entry name" value="PrsW"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36844">
        <property type="entry name" value="PTHR36844"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13367">
        <property type="entry name" value="PrsW-protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="35"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="58"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="86"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="118"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="152"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="193"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="223"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="282"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN10739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="316" mass="34088" checksum="0CB00F135AC5C58E" modified="2018-04-25" version="1">MTQAQPPGAPRARIPGPKRPPSSVPQIRAGLWKHWLWGGLALWTLTAVVTFATRNTTLLPTLILLGSFLAPGTFVLWAYERHARDLGVSLMLGCFAAGGVLGVLGASVMEYHLLHPSLWMSVGVGLTEEAVKLAALMYVLRTQPRVRGLRAGLVLGASVGFGFAAFESAGYAFDAAVGTQGIDLRSLLETEVLRGLLAPFGHGLWTAISGAVLLVFRRPNGRYRFAAPVVLTYVGVSLLHALWDSMHGIAIWTVARLTDTDLPLTLFTEGYIPQPTGTQKHLFTLFSVGGLVIISLAGIAWVRSLAHREPPWRNTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-05-25" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JV51</accession>
    <name>A0A2M9JV51_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 3">Single-stranded DNA-binding protein</fullName>
            <shortName evidence="2">SSB</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CG723_16385</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CB01635</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2">Homotetramer.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000004">
        <property type="protein sequence ID" value="PJN10761.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN10761">
        <property type="protein sequence ID" value="PJN10761"/>
        <property type="gene ID" value="CG723_16385"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04496">
        <property type="entry name" value="SSB_OBF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00984">
        <property type="entry name" value="SSB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000424">
        <property type="entry name" value="Primosome_PriB/ssb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011344">
        <property type="entry name" value="ssDNA-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00436">
        <property type="entry name" value="SSB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002070">
        <property type="entry name" value="SSB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50935">
        <property type="entry name" value="SSB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="88"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="138"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR002070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PJN10761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="171" mass="19089" checksum="EB171F717DCDE7BB" modified="2018-04-25" version="1">MSETTVTVVGNVATTPVYRELPKGPVARFRLAATARRFDRVRNEWVDGHTNFFTVWAWGTLGTNVQGSLSIGEPVLVQGRLRVRDEERGGQHWTSADIQASAVGHDLSRGTTAFRRSRQTRPGRQPDGDEPSFEIEPQGESEPQQDQPDQPDQPDQQDQQQSDRREPAVVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JVA9</accession>
    <name>A0A2M9JVA9_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Beta-lactamase2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_16110</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000004">
        <property type="protein sequence ID" value="PJN10717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN10717">
        <property type="protein sequence ID" value="PJN10717"/>
        <property type="gene ID" value="CG723_16110"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008800">
        <property type="term" value="F:beta-lactamase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030655">
        <property type="term" value="P:beta-lactam antibiotic catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046677">
        <property type="term" value="P:response to antibiotic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045155">
        <property type="entry name" value="Beta-lactam_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000871">
        <property type="entry name" value="Beta-lactam_class-A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35333">
        <property type="entry name" value="PTHR35333"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13354">
        <property type="entry name" value="Beta-lactamase2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014618177" description="Beta-lactamase2 domain-containing protein" evidence="1">
        <location>
            <begin position="35"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-lactamase2" evidence="2">
        <location>
            <begin position="120"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN10717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="308" mass="32323" checksum="3648F9B038642AC7" modified="2018-04-25" version="1">MTRRISIRAARVLPAVLAAGVLVPVVAGAAPASAATTPQVTCTSDKAGLAGKLQKDITAALATRKGTVAVGLHDRTTNTTCSLRATSSYDSASVVKVTVLATLLWDAKKTNRYLTTREANLATAMITKSDNAATTSLWKQLGTTKVKGFLKAAGMTRTVPGSGGYWGLTQINVQDEQKLLSLVTAKNSVLSDNSRAYILKLMGKVVSSQRWGTPAGAPASVAVHVKNGWLERSTYGWRVHSIGAFQGGGHDYTISVLTHGNSTMSYGVDTIQGVARVIHKDLTPTAPAASRYTPTSTPKEAFVAVPQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-05-25" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JVG0</accession>
    <name>A0A2M9JVG0_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Probable nicotinate-nucleotide adenylyltransferase</fullName>
            <ecNumber evidence="6">2.7.7.18</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Deamido-NAD(+) diphosphorylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Deamido-NAD(+) pyrophosphorylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Nicotinate mononucleotide adenylyltransferase</fullName>
            <shortName evidence="6">NaMN adenylyltransferase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">nadD</name>
        <name evidence="9" type="ORF">CG723_16930</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CB01635</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 6">Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>ATP + H(+) + nicotinate beta-D-ribonucleotide = deamido-NAD(+) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22860"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57502"/>
            <dbReference type="ChEBI" id="CHEBI:58437"/>
            <dbReference type="EC" id="2.7.7.18"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 6">Cofactor biosynthesis; NAD(+) biosynthesis; deamido-NAD(+) from nicotinate D-ribonucleotide: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the NadD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.18" evidence="6"/>
    <dbReference type="EMBL" id="NNBL01000004">
        <property type="protein sequence ID" value="PJN10854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN10854">
        <property type="protein sequence ID" value="PJN10854"/>
        <property type="gene ID" value="CG723_16930"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00253">
        <property type="reaction ID" value="UER00332"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004515">
        <property type="term" value="F:nicotinate-nucleotide adenylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009435">
        <property type="term" value="P:NAD biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02165">
        <property type="entry name" value="NMNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00244">
        <property type="entry name" value="NaMN_adenylyltr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004821">
        <property type="entry name" value="Cyt_trans-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005248">
        <property type="entry name" value="NadD/NMNAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01467">
        <property type="entry name" value="CTP_transf_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00125">
        <property type="entry name" value="cyt_tran_rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00482">
        <property type="entry name" value="TIGR00482"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 6" id="KW-0520">NAD</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 9" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="4 6" id="KW-0662">Pyridine nucleotide biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="CTP_transf_like" evidence="8">
        <location>
            <begin position="32"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001785"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PJN10854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="220" mass="23938" checksum="7E43935B5C571EAA" modified="2018-04-25" version="1">MGEQDMPTGPVNGPAGGPDRARISTAKRRLGVMGGTFDPIHHGHLVAASEVAAQFHLDEVVFVPTGQPWQKADRTVTPAEDRYLMTVIATAENPQFSVSRIDIDRGGPTYTTDTLRDLRALNPDSDLFFITGADALGQILTWRYTEELFSLAHFIGVTRPGHPLTDPGLPEGGVSLVEVPALAISSTDCRARVAKGAPVWYMVPDGVVRYIDKRELYRGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JVL6</accession>
    <name>A0A2M9JVL6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Acyl-CoA dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CG723_16070</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CB01635</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000004">
        <property type="protein sequence ID" value="PJN10936.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN10936">
        <property type="protein sequence ID" value="PJN10936"/>
        <property type="gene ID" value="CG723_16070"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003995">
        <property type="term" value="F:acyl-CoA dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006089">
        <property type="entry name" value="Acyl-CoA_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="SSF47203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="SSF56645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00073">
        <property type="entry name" value="ACYL_COA_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0274">FAD</keyword>
    <keyword evidence="3 5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA_dh_N" evidence="8">
        <location>
            <begin position="7"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_M" evidence="7">
        <location>
            <begin position="123"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_1" evidence="6">
        <location>
            <begin position="235"/>
            <end position="383"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PJN10936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="385" mass="42276" checksum="BAB91B8B1BA3C511" modified="2018-04-25" version="1">MRRTVYNEDHEAFRDTIRAFIEAEVVPVYDEWFAAGQAPRDFYYKLAELGVFGIRVPEEFGGAGIDSYKFEAVMYEETSRAGVQFGGSGVHVLLGLPYIKMLATDEQKKRFLPKFVSGEEMWALAMTEPGTGSDLAGMKTTAKLSEDGTHYVLNGAKTFITGGVHADKVIVCARTDAPTAEDRRHGISLFAVDTKSEGYSIGRKLDKLGLKTSDTAELAFVDVKVPVEDLLGEENKGFYYLGHNLASERWGIAFGAYAQAKAAVRFAKEYVQERAVFGKPVASFQNTKFELAACQAEVDAAEAVADRALEALDAGELTPAEAASAKLFCTEVAHRVIDRCLQLHGGYGFMNEYPIARLYADNRVNRIYGGTSEIMKTIIAKDMGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JVU3</accession>
    <name>A0A2M9JVU3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_08180</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN10979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN10979">
        <property type="protein sequence ID" value="PJN10979"/>
        <property type="gene ID" value="CG723_08180"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="16"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="46"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="77"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="112"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN10979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="161" mass="17436" checksum="E5D66AA994C7FEF3" modified="2018-04-25" version="1">MVWEPAFTLGAYHVVFYYQLLSLWAVSTGVLLSALLLRERLPRHGWMYLACLALPSVWLSIAAIVPHKGGTPRELLFLAGGILSVIGTPVLTWTLLRILLFGESELSARQQWRVVGTIALVGVLAFTLGSLNHVFLTCGDFNVSGNSVPKGCRPGSASPFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JVW8</accession>
    <name>A0A2M9JVW8_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Anti-sigma factor antagonist</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CG723_08095</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CB01635</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the anti-sigma-factor antagonist family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN10968.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN10968">
        <property type="protein sequence ID" value="PJN10968"/>
        <property type="gene ID" value="CG723_08095"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043856">
        <property type="term" value="F:anti-sigma factor antagonist activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.750.24">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003658">
        <property type="entry name" value="Anti-sigma_ant"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002645">
        <property type="entry name" value="STAS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036513">
        <property type="entry name" value="STAS_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01740">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52091">
        <property type="entry name" value="SSF52091"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00377">
        <property type="entry name" value="ant_ant_sig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50801">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="STAS" evidence="3">
        <location>
            <begin position="13"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PJN10968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="137" mass="14989" checksum="FF2845984D28B217" modified="2018-04-25" version="1">MAMRTNIIRHENMMVSYDVVNGWTVIEVDGEVDAHTAPVIREGVIKLLNEGHCHFVLDLGFVTFMDSMGLGMIVAVTKRLREHEGALRIAAASSRVLKIFDLSGMRESYEIFPSTAEATASAPLPGSLAHWPHPSSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JW39</accession>
    <name>A0A2M9JW39_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">3-hydroxybutyryl-CoA dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CG723_09185</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN11125.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN11125">
        <property type="protein sequence ID" value="PJN11125"/>
        <property type="gene ID" value="CG723_09185"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070403">
        <property type="term" value="F:NAD+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022694">
        <property type="entry name" value="3-OHacyl-CoA_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006176">
        <property type="entry name" value="3-OHacyl-CoA_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006108">
        <property type="entry name" value="3HC_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00725">
        <property type="entry name" value="3HCDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02737">
        <property type="entry name" value="3HCDH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000105">
        <property type="entry name" value="HCDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="SSF48179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="3HCDH_N" evidence="4">
        <location>
            <begin position="7"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="domain" description="3HCDH" evidence="3">
        <location>
            <begin position="189"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="50"/>
        </location>
        <ligand>
            <name>CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="57"/>
        </location>
        <ligand>
            <name>CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="121"/>
        </location>
        <ligand>
            <name>CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
        </ligand>
    </feature>
    <feature type="site" description="Important for catalytic activity" evidence="1">
        <location>
            <position position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR000105-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000105-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PJN11125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="286" mass="30223" checksum="9F80EB7BC4B448F8" modified="2018-04-25" version="1">MIPISRVGVVGSGAMGAGIAEVSALAGMDVLVAVSREASLTTGRHRVLASLDRAVVKGRLAAAERDAAAARIGFTMDLGELADRQLVVEAVREEETLKLDLFATLDKVVEDPEAILASNTSSIPIMKLAGATGRPAQVIGTHFFNPVPAMPLVELVGSLHTSDATMDRAESWVAQTLGKRPIRSKDRAGFVVNALLVPYLLSAVRMAETGFATVDDIDQGMVLGCSHPMGPLRLTDMVGLDVVAAVADALYEEFKEPLYAAPPLLSRMVEGGLLGRKSGRGFYPYP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JW87</accession>
    <name>A0A2M9JW87_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">TCAD9 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_09140</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN11119.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN11119">
        <property type="protein sequence ID" value="PJN11119"/>
        <property type="gene ID" value="CG723_09140"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045544">
        <property type="entry name" value="TCAD9"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19974">
        <property type="entry name" value="TCAD9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TCAD9" evidence="2">
        <location>
            <begin position="178"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="775"/>
            <end position="795"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF19974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN11119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="1608" mass="179455" checksum="8013CA476C64CBDE" modified="2018-04-25" version="1">MSTASDLEGPAPQAQQPSLHSRADAIIQSELGTEVSITYLQELNDGYTDALVARCDFMGAQQGGLDGQFIVKVSTDGQGRQHEAHERFSTALGGFAEEHVPALRLSAGGDGLRVDVYEIAGGSLRNVGAAEMAHSPRLLAACRTVSAELLEAQLSGCTGVRMQAGRTLDAWLGEGFLRARRGDALRETRRMADISGSTFVFHGEVLPDPVSVLEQENELTRRSDLVLMGFSHGDLHLRNILLDATRSYRGSYWLIDVNWGHESPLLYDQAYLETAALISMQSRLRVPVPLAVLQECDGLISAAGLEWQGLVSAVRAVRDGTHESINRLQPGRVDSLTHQYLLARLGAALNYAAKNMPERDRVTAYQLAGWITHNLLKEYHPELRQRVLEQAQSPRAPREAVVAPARPTDVEALAERLAPFLATAHSGYDRILIVEAGVSHPDLAHLLAPQWTVIVDLSPESERSGLARHFDPETAEKQTVMFGLHEAPSSGRNTVSWIMAGGWETRGETAPAAFVEWRRSHLPVVRGVLDRSSGASVNRAAAVLCISAGSDPDQRSERIMEEVEVLYEQTKNLVHVPCDGDEFRALLDAFGNAQAMARPDRLATLPGQDGPVPFEQEQLVRLAADLVVLHSRILVDELREEPVDEFWRGRPASWVDLDAGLDVPRDTQPMVQGAIGRVLRKHSSATFEIFHTPGAGGTTLARRIAWDLHRDHPVVFLHHYGQQTVERIDDIYRATKKSVLVVVESATLGQSEREDLYYKLHERNTPAVVLWVTRGNRPTADPDAPASGKGRKDDNKFYLKEPLSAEEAREFRAIFGARARSPRARAAVERLIPGSAPEQHLSPFYFGLSAFEEDFEGTRRYVDSHVAHFNDLQRSVAGYLSLVTRFTQNGLPYFLVRRWLTGAWGGQAGSAAAYQEDLRSTLGEDLRHLSVENDEEVRILHPSVAEKVLESVLESVRGDRDWEFLLANTAIEFISQVSGHLGPDNAWTKEILQNLFIRRDKWSGSTSNSQRFAEFIHEFENKDQAYRVLEELTRRCPSEPHFWLHLGRFHASVRGHLDGKAETLIKKAIDLSDELDPVPFHSLAMLHRESVRDELIQLGSNTGREDEAITRIRDRYDEALRVFGRARQLNGIDEHNYVTPVQMIVTVLNHLRRISRHSNLIDLIRAGGMAADWASEQLSIAELLLDECELARPDHQDSSYLSSCKVSLDTLHGGVKSLVSAWRDLVVQSRSHSRVALVLARALLREHGDDWQETSPEVFRTAVEFYDAAFDERGDLSDHDVQLWFRCYRRLPEYDELAALERFSFVASSRPSPVCRYYLYVLRFMRWLNEDELKQDAVEHHMAEAKALMQGRRKAFSYEWVAKDKSGKGADIAPRLAHFSELGERRPATHDWENSANVCRRVRGVVRKIEGQQAGWLAVEDGSIEAFFVPREEFLRHRDINKVVEFDLGFAQDGLRAWRVEVAKEARLLRRPDVEIRTVEVAPIPLPSQVSLPRPGGGIAPAPKAIAVSPEIREQALDLASTNERDAYRLVIGHLVSCASGTTAVTSLNLGVVLQKTFGDTSYTRALSGTKLRSYVEALGFRVTSTAHGQFAVTFDDAEKGAEKGSDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JWH7</accession>
    <name>A0A2M9JWH7_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 15">Argininosuccinate synthase</fullName>
            <ecNumber evidence="6 15">6.3.4.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14 15">Citrulline--aspartate ligase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="primary">argG</name>
        <name evidence="17" type="ORF">CG723_10010</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">CB01635</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 15">
            <text>ATP + L-aspartate + L-citrulline = 2-(N(omega)-L-arginino)succinate + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10932"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57472"/>
            <dbReference type="ChEBI" id="CHEBI:57743"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.3.4.5"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 15">Amino-acid biosynthesis; L-arginine biosynthesis; L-arginine from L-ornithine and carbamoyl phosphate: step 2/3.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5 15">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 15">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 15">Belongs to the argininosuccinate synthase family. Type 2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.5" evidence="6 15"/>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN11260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN11260">
        <property type="protein sequence ID" value="PJN11260"/>
        <property type="gene ID" value="CG723_10010"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00068">
        <property type="reaction ID" value="UER00113"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004055">
        <property type="term" value="F:argininosuccinate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042803">
        <property type="term" value="F:protein homodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006526">
        <property type="term" value="P:arginine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.400">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00581">
        <property type="entry name" value="Arg_succ_synth_type2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023437">
        <property type="entry name" value="Arg_succ_synth_type2_subfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001518">
        <property type="entry name" value="Arginosuc_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018223">
        <property type="entry name" value="Arginosuc_synth_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024074">
        <property type="entry name" value="AS_cat/multimer_dom_body"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024073">
        <property type="entry name" value="AS_multimer_C_tail"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11587">
        <property type="entry name" value="PTHR11587"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00764">
        <property type="entry name" value="Arginosuc_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69864">
        <property type="entry name" value="SSF69864"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00032">
        <property type="entry name" value="argG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00564">
        <property type="entry name" value="ARGININOSUCCIN_SYN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00565">
        <property type="entry name" value="ARGININOSUCCIN_SYN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 15" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="9 15" id="KW-0055">Arginine biosynthesis</keyword>
    <keyword evidence="13 15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 15" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10 15" id="KW-0436">Ligase</keyword>
    <keyword evidence="12 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="463"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <begin position="17"/>
            <end position="25"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="43"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="99"/>
        </location>
        <ligand>
            <name>L-citrulline</name>
            <dbReference type="ChEBI" id="CHEBI:57743"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="129"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="131"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="135"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="136"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="139"/>
        </location>
        <ligand>
            <name>L-citrulline</name>
            <dbReference type="ChEBI" id="CHEBI:57743"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="192"/>
        </location>
        <ligand>
            <name>L-citrulline</name>
            <dbReference type="ChEBI" id="CHEBI:57743"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="194"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="201"/>
        </location>
        <ligand>
            <name>L-citrulline</name>
            <dbReference type="ChEBI" id="CHEBI:57743"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="203"/>
        </location>
        <ligand>
            <name>L-citrulline</name>
            <dbReference type="ChEBI" id="CHEBI:57743"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="280"/>
        </location>
        <ligand>
            <name>L-citrulline</name>
            <dbReference type="ChEBI" id="CHEBI:57743"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00014810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00029916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="PJN11260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="482" mass="52454" checksum="33C4AFFBAEA34286" modified="2018-04-25" version="1">MSKVLTSLPAGERVGIAFSGGLDTSVAVAWMRDKGAVPCTYTADIGQYDEPDIASVPGRAKTYGAEIARLVDCRAALVEEGLAALACGAFHIRSGGRAYFNTTPLGRAVTGTLLVRAMLEDNVQIWGDGSTFKGNDIERFYRYGLLANPHLRIYKPWLDADFVTELGGRKEMSEWLVSHDLPYRDSTEKAYSTDANIWGATHEAKTLEHLDTGVETVQPIMGVRFWDPSVEIAAEDVTIGFEQGRPVTINGKAFASAVDLVMEANAIGGRHGMGMSDQIENRIIEAKSRGIYEAPGMALLHAAYERLVNAIHNEDTLAQYHNEGRRLGRLMYEGRWLDPQALMVRESLQRWVGSAVTGEVTLRLRRGEDYSILNTTGPAFSYHPDKLSMERTEDSAFGPVDRIGQLTMRNLDIADSRARLEQYAGLGIVGTTHPELIGAAQAAATGLIGAMPEGGAEVIASRGEVSEEDELLDRAAMESGTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-05-25" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JWJ0</accession>
    <name>A0A2M9JWJ0_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">YceI domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_09970</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN11253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN11253">
        <property type="protein sequence ID" value="PJN11253"/>
        <property type="gene ID" value="CG723_09970"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.128.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008969">
        <property type="entry name" value="CarboxyPept-like_regulatory"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007372">
        <property type="entry name" value="Lipid/polyisoprenoid-bd_YceI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036761">
        <property type="entry name" value="TTHA0802/YceI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04264">
        <property type="entry name" value="YceI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00867">
        <property type="entry name" value="YceI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101874">
        <property type="entry name" value="SSF101874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49464">
        <property type="entry name" value="SSF49464"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YceI" evidence="1">
        <location>
            <begin position="123"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN11253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="303" mass="33107" checksum="ADF5096726AB84AE" modified="2018-04-25" version="1">MPLALFRRSRSGRDPRGAGLVHPVPHGAGAFHCEVADPMGQPMSGADVTVTRVANGRVVAKVTSDPYGLVFLTLPPGRYGVMIAADGLQPHQQTLDVVAGETLPLTSVQLHMGRPPELPQPGTWLFDPPHTAIRFIAKHVGMAHVHGRFTRFDGGIQVANDMADSRVEVQIDAASITTGNKTRDNHLRSADFLDVERYPYIHFSSDRFLYRGGTKWTIQGALTMHGVSRTVELDTGYLGMVNGGYAEELRCAALATAELHREDYTLDWRSMLARGIAVVGPTVKLELDIQAMYHSHDTPTPPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JWQ8</accession>
    <name>A0A2M9JWQ8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Dodecin family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CG723_10420</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN11336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN11336">
        <property type="protein sequence ID" value="PJN11336"/>
        <property type="gene ID" value="CG723_10420"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1660.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009923">
        <property type="entry name" value="Dodecin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025543">
        <property type="entry name" value="Dodecin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036694">
        <property type="entry name" value="Dodecin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39324">
        <property type="entry name" value="PTHR39324"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07311">
        <property type="entry name" value="Dodecin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89807">
        <property type="entry name" value="SSF89807"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PJN11336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="71" mass="8025" checksum="69E3FACAB77D4AB2" modified="2018-04-25" version="1">MSDHTYRVTEIVGTSHEGVDQAIRNGIARASQTLRGLDWFEVCQVRGHIENGQIEHYQVGLKVGFRLEDEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JXB3</accession>
    <name>A0A2M9JXB3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">TetR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CG723_11525</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN11524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN11524">
        <property type="protein sequence ID" value="PJN11524"/>
        <property type="gene ID" value="CG723_11525"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041678">
        <property type="entry name" value="TetR_C_16"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17920">
        <property type="entry name" value="TetR_C_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="3">
        <location>
            <begin position="55"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="78"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="38"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PJN11524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="235" mass="25175" checksum="0F31170E2965D5FD" modified="2018-04-25" version="1">MEGASPSAARPGGRTRPSKERDPVTSPAPTASAESESTSGVRDDHRSGPARRDAEATKTAIIRACRHLLARHAHTDITLKAVAERAGVSAPLILKYFGNKDALFSQVMNFEADVETFLDAPLEDLGRHMVRHLLTGQSEHGADPILRIVFAPLHGEQGDILRANFRAQVSDRLAERLRGPDAGLRAELAVSLLLGLGVMYGIARGPHVRSASVEEITERYGPAVQAQLTPGTLTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-05-25" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JY02</accession>
    <name>A0A2M9JY02_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Nitroreductase family deazaflavin-dependent oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_12800</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>a quinol + H(+) + oxidized coenzyme F420-(gamma-L-Glu)(n) = a quinone + reduced coenzyme F420-(gamma-L-Glu)(n)</text>
            <dbReference type="Rhea" id="RHEA:39663"/>
            <dbReference type="Rhea" id="RHEA-COMP:12939"/>
            <dbReference type="Rhea" id="RHEA-COMP:14378"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
            <dbReference type="ChEBI" id="CHEBI:133980"/>
            <dbReference type="ChEBI" id="CHEBI:139511"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the F420H(2)-dependent quinone reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN11732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN11732">
        <property type="protein sequence ID" value="PJN11732"/>
        <property type="gene ID" value="CG723_12800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004378">
        <property type="entry name" value="F420H2_quin_Rdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04075">
        <property type="entry name" value="F420H2_quin_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00026">
        <property type="entry name" value="hi_GC_TIGR00026"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00029371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN11732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="145" mass="15993" checksum="806ACAA2B666A5F4" modified="2018-04-25" version="1">MAKSYRVGLGTRAVNRVFATMTRLGIGKGYRYILTVKGRKSGRPYSTPVDVMSAGGERWLVAAYGVSDWVRNARVAGEVGLSRGGRSQNLRVVELGPEESVPVLRQYLREVPVTRAYFDVTPDSSDEEFAAESARHPVFHLVSFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JY29</accession>
    <name>A0A2M9JY29_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">IclR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CG723_12950</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN11758.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN11758">
        <property type="protein sequence ID" value="PJN11758"/>
        <property type="gene ID" value="CG723_12950"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014757">
        <property type="entry name" value="Tscrpt_reg_IclR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005471">
        <property type="entry name" value="Tscrpt_reg_IclR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09339">
        <property type="entry name" value="HTH_IclR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01614">
        <property type="entry name" value="IclR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00346">
        <property type="entry name" value="HTH_ICLR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51077">
        <property type="entry name" value="HTH_ICLR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51078">
        <property type="entry name" value="ICLR_ED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH iclR-type" evidence="3">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="domain" description="IclR-ED" evidence="4">
        <location>
            <begin position="65"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PJN11758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="253" mass="27780" checksum="5BDEB45C5FDCDBCC" modified="2018-04-25" version="1">MKSALRTVALLELLAARDDRPARLDELAEEMDVPRSSMYQLLRTLVDCGWVRTDTTGSLYGIGIRTLLTGTSYLDSDPHVRTVRPYLDEASDALGETIHLARLDGPYVVYLATRESHEYLRTISRVGRRVPAHAGALGKALLAERADSELPLGDGPLTALTENTHTDRAALLADLTEVRERGYSLDHEETVTGIAGFGFALRYDVPAVDAISCSVPVARLTGERQERVVAVMRDVQTKIEALLSPRSGAPDWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JY65</accession>
    <name>A0A2M9JY65_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Peptide ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CG723_13265</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN11809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN11809">
        <property type="protein sequence ID" value="PJN11809"/>
        <property type="gene ID" value="CG723_13265"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015833">
        <property type="term" value="P:peptide transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013563">
        <property type="entry name" value="Oligopep_ABC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08352">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01727">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="6">
        <location>
            <begin position="12"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="318"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="46"/>
            <end position="53"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PJN11809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="337" mass="36200" checksum="FDA28FF731C50BA4" modified="2018-04-25" version="1">MTTPEAAPMLAIRDLRVSFPTDDGVVHAVNGMDLTLARGETVGIVGESGSGKTVTSQALMGLLKDTTAAVTGQILLDGQDLNTLTETQMRAYRGKKIAMIFQDPLSAMHPFYPVGAQIAEAYRVHNNVSKKAAAQVAVDMLGRVGIPDPKRRYSAYPHEFSGGMRQRAMIAMALVCEPELLIADEPTTALDVTVQAQILDLLNELQDETGTSVILVTHDLGVVAEVCHQVVVMYGGECVEQATVANLFKDPRHPYTQGLLASMPSLAQRSERLNPIPGFPPSLLALPDGCLFADRCPKTHLVPDDACGTRRPTLTGIDGHPSRCHLETLQPTGEAAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JYH8</accession>
    <name>A0A2M9JYH8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CG723_14000</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CB01635</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN11929.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN11929">
        <property type="protein sequence ID" value="PJN11929"/>
        <property type="gene ID" value="CG723_14000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="34"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="98"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="131"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="179"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="224"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="286"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="94"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PJN11929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="323" mass="35936" checksum="7C5E5DC86EF88DB6" modified="2018-04-25" version="1">MSTVSTRAPSRPAPDTDRQVPARRRRRQVRERQWPAYVFLSPWMIGALVLTLVPMAVSLYLSFTDYNLFDPPRWVGLRNYTEMLTEDPRYWRSVGTTMLYVVVAVPLKLGLALGVAMLLKNLNRGRAFYRSAFYAPSLLGASMSIALVWKALFNDGGTVSGLLDSVGIDVGGWVGNPHLAVYVVVLLTVWQFGAPMVIFLAGLQQISPDLYEAASLDGAGRRRQFVSITVPMLSPVIFFNLVLEIINSFQVFTPAFVISGGKGAPADSTMFYTLYLYERGFTASHMGYAAAMAWMLLIAIAAITLILFRTSRSWVFYADEEGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JYV9</accession>
    <name>A0A2M9JYV9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DNA-binding response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CG723_14115</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN11947.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN11947">
        <property type="protein sequence ID" value="PJN11947"/>
        <property type="gene ID" value="CG723_14115"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="4"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="domain" description="HTH luxR-type" evidence="3">
        <location>
            <begin position="151"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PJN11947.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="229" mass="24858" checksum="0C826827C159ADF4" modified="2018-04-25" version="1">MTIRVLLADDQALLRGTFKMLFDSADDMETVGEAANGREAVDLCEELHPDVVLMDIRMPEMDGLDATRLISESEDLAGVKVLILTTFEDDEHVAEALRAGASGFLGKGVRPDVLLEAVRTVAAGEALLSPVATRALISRFLAQPELYPAVVQERLQYLTPRERDVMCLVALGLSNEDIAERLFVSPLTAKTHVNRAMTKLAARDRAQLVVMAYQCGLVSPAVEPTGPQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JYZ9</accession>
    <name>A0A2M9JYZ9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CG723_08995</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CB01635</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AfsR/DnrI/RedD regulatory family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN12105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN12105">
        <property type="protein sequence ID" value="PJN12105"/>
        <property type="gene ID" value="CG723_08995"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043531">
        <property type="term" value="F:ADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd15831">
        <property type="entry name" value="BTAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005158">
        <property type="entry name" value="BTAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002182">
        <property type="entry name" value="NB-ARC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03704">
        <property type="entry name" value="BTAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00931">
        <property type="entry name" value="NB-ARC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01043">
        <property type="entry name" value="BTAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0902">Two-component regulatory system</keyword>
    <feature type="domain" description="OmpR/PhoB-type" evidence="4">
        <location>
            <begin position="1"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="3">
        <location>
            <begin position="1"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PJN12105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="1070" mass="115660" checksum="94FAD67F2FBFBE2F" modified="2018-04-25" version="1">MDLGPVKGQAVLSALLLSQGAMVSHERLLDAVWGLGLPAGGRKVLPTHVNSLRRTLDPDGTPPAESVIRSGRGWYRFAVEGVRLDTTDLEDRGGEAMRSVAAGDLATAADQLSAVIGLFRGEPLAGLPGPFAQEERRRWEERRRTLRLEWLKCLVLLGRYGEALDGLSGVASASDRYDESLTALRMRALYGCGRQAEALNAFEDLRVRLRDELGADPGEELRRVHEAVLHQDSTFLQRPPTTSPPRESAVPAELPHNAAGFVGRTGELIRLHALFPPAQEQGPANTVVISAIGGAAGIGKTALAVHWAHQARDRFPDGQLYVNLHGFDHDRQPLEPREALELLLRSLGLAASEIPARAEAQGRVFRTLLADRRLLVLLDNAASAEQVRPLLPGSPTCCVIVTSRNRLGGLVAHDGAHALPLDLLQPDEARALLGRTLGADRVAADEHAVGELIRLCGSLPLALRVAAARLAGDPGLRLADLVAEMTAGNRLAALEPDDDAGSPLRTAFSVSYRVLAPPARRLFRLLGLFPGAEFTAEATGALADAPPQQARRLLSTLAAAHLIEPTTVGRYRFHDLLRAYAHECAQAEETAADRDAALERLLLWYLHAARAVGGTWLFPELPPGLGHGGQPGLPTATGSSPWLEAEQANLLAVIRHAAHHGPRPVAWHMVNALFGYFLLRLPRAAWQATTQAALDAATAEDNLFGQAAMHVSLGLVQADQGDPDQALEHHTRARDISRELGWATGEAVAIGGQGQAEWYMARLHSAHEHVTTGMRIAREAGNLYLETLGLMVTGLACRDLGRLHEAAEQFELAISRSKWISWWDDSLALENLGWVYWELGRLADGLDALAPKGAAGETDGSRNARATVLNAVAKINITLGRHDEALEQAMRALAKAQDTGRRWIQASILNTVAAAHREMTHFNRAMQVGSQALALARESRYVRLEADGLLDLSLTLKKLGRIDEARAHAEQALALARARSFRVVEGQALTALCDIAASEEAHATAVELGREALTIHRETGHRPGEARTLLALARAHRKTDGPAAELMRQQAWDIFSDIGVPTKEDEDLDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JZ21</accession>
    <name>A0A2M9JZ21_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CG723_09200</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CB01635</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN12108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN12108">
        <property type="protein sequence ID" value="PJN12108"/>
        <property type="gene ID" value="CG723_09200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="37"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="65"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="90"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="124"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="154"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="199"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="236"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="266"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="293"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="329"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="358"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="1"/>
            <end position="388"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PJN12108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="388" mass="40002" checksum="837B3B4C244C1F99" modified="2018-04-25" version="1">MALSCLLVFMAQMATTIYLPSLPIVAHDFGMSRSYAALSISAFVIGAAAPVVLWGVAADRYGRRGPLLTSLALFVLTSAAIALIRSPEGLLVLRALQGIGAGGSAIIARILVRDRWSGDELARRLSVLSIAFITAMGGGQFLGGLIGRYAHWEAGFVVLATVGAIAAALTFTVPFESGRTVQRPSEVLRICLTISRQPGFLLPALAGGAGFATIVLLQEVSPFVFQEHFGLATDQYGSLGLLLGAAYFAGAMTVNRLVARAGSSRLMTAGSIVMTASGVLMIALWSVPGLPDTGVLVAFVALYCVTTFGQSVLFPNSMATAVTSQQGHGAYAVSLCGFLQQSMAGVAAAGAALLHADLAWATVAAALGAAAWLLTRIAVPTAVVKEGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JZT2</accession>
    <name>A0A2M9JZT2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_04905</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000002">
        <property type="protein sequence ID" value="PJN12389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN12389">
        <property type="protein sequence ID" value="PJN12389"/>
        <property type="gene ID" value="CG723_04905"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="56"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="26"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN12389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="221" mass="23868" checksum="BE01C89143ECFADC" modified="2018-04-25" version="1">MSTTRHHINRTRRLAAAPRPRRTETVTEPTPLRKRPVKEPVAAESSSHPHSPPGRALVVICVLTLLLGAFAGWAHSRAAAERDVPAARNTALTDVARTSEIKGRTDKAVADLFSYDYAHPEVAREAVSSLLTGRAVTEHKQLLGPVLAQADKSKAVITTTVTESAVERISGDRARVLVFADQSSSTTHGKSGTAYAGAMFAVEWVRQDGRWLVSGIDTFGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K094</accession>
    <name>A0A2M9K094_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CG723_05830</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000002">
        <property type="protein sequence ID" value="PJN12551.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN12551">
        <property type="protein sequence ID" value="PJN12551"/>
        <property type="gene ID" value="CG723_05830"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PJN12551.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="92" mass="10016" checksum="FB085F079B6CDBE6" modified="2018-04-25" version="1">MIVRIMGEGQVELADSHFTELNKLDNELLAEMENGDGPAFRRTLNALLETVRSLGTPLPDASLEPSELILPSPDATLEEVREMLSDDGLIPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K0B3</accession>
    <name>A0A2M9K0B3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">AsnC family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_05935</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000002">
        <property type="protein sequence ID" value="PJN12572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN12572">
        <property type="protein sequence ID" value="PJN12572"/>
        <property type="gene ID" value="CG723_05935"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019887">
        <property type="entry name" value="Tscrpt_reg_AsnC/Lrp_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01037">
        <property type="entry name" value="AsnC_trans_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AsnC_trans_reg" evidence="1">
        <location>
            <begin position="6"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN12572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="93" mass="9970" checksum="93735349B5ACFFBF" modified="2018-04-25" version="1">MITAIVLIKTSVDRIPEIAESIAALDSVSEVFSVTGTYDLIAMVRVARHDDLADVIPGKISKIPGVEATDTHVAFRTYSQHDLEAAFAIGLDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K0K5</accession>
    <name>A0A2M9K0K5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_06465</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000002">
        <property type="protein sequence ID" value="PJN12665.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN12665">
        <property type="protein sequence ID" value="PJN12665"/>
        <property type="gene ID" value="CG723_06465"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="38"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN12665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="80" mass="7796" checksum="9AF70FFA115C2D10" modified="2018-04-25" version="1">MADSSHGHTPAAWTGVIIAFIGFCVAGAFMVMGDPVGFWAGMALLAVAAVVGGAMSAAGLGKPKPQSLPAVSPEVVAAEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K0S9</accession>
    <name>A0A2M9K0S9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ribosome-associated heat shock protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_06950</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000002">
        <property type="protein sequence ID" value="PJN12743.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN12743">
        <property type="protein sequence ID" value="PJN12743"/>
        <property type="gene ID" value="CG723_06950"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00165">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002942">
        <property type="entry name" value="S4_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036986">
        <property type="entry name" value="S4_RNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01479">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00363">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0346">Stress response</keyword>
    <feature type="domain" description="S4" evidence="2">
        <location>
            <begin position="44"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="128"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="143"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN12743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="180" mass="18643" checksum="5CC382196FFBA1E6" modified="2018-04-25" version="1">MASDTASDSGSGTRSGTGSGTGSDAASSAVDAARAAAPGAGESVRIDSWIWSVRLAKTRSAGATACRGGHVKVNGDRVKAAYNVRVGDEVRVRQAGGHERVVIVKRLIRKRVGAPVAVECYVDNSPPPPPRAAVAPVAIRDRGAGRPTKRDRRDMDRLRATFGAGPVPPAQDHADGREKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K178</accession>
    <name>A0A2M9K178_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cob(I)yrinic acid a,c-diamide adenosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">cobO</name>
        <name evidence="2" type="ORF">CG723_07710</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000002">
        <property type="protein sequence ID" value="PJN12885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN12885">
        <property type="protein sequence ID" value="PJN12885"/>
        <property type="gene ID" value="CG723_07710"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008817">
        <property type="term" value="F:cob(I)yrinic acid a,c-diamide adenosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009236">
        <property type="term" value="P:cobalamin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003724">
        <property type="entry name" value="CblAdoTrfase_CobA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02572">
        <property type="entry name" value="CobA_CobO_BtuR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015617">
        <property type="entry name" value="Adensltrnsf_CobA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00708">
        <property type="entry name" value="cobA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN12885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="199" mass="22380" checksum="4D84BC9C55625D47" modified="2018-04-25" version="1">MPQGQPSVVPDDGLTTRQRRNRPLVVVHTGIGKGKSTAAFGLALRAWNQGWPIGVFQFVKSAKWKVGEENALRVLGASGEGGSVDWHKMGEGWSWVQRDAQMDNEEKAREGWEQVKRDLAAETYQLYVLDEFAYPMHWGWIDTDEVISVLRDRPGTQHVVITGRNAPEKLLDFADLVTDMSKVKHPMDAGQKGQRGIEW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K1D7</accession>
    <name>A0A2M9K1D7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Sugar ABC transporter substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_04110</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000002">
        <property type="protein sequence ID" value="PJN12953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN12953">
        <property type="protein sequence ID" value="PJN12953"/>
        <property type="gene ID" value="CG723_04110"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006059">
        <property type="entry name" value="SBP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01547">
        <property type="entry name" value="SBP_bac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN12953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="399" mass="42958" checksum="057D4826254407C9" modified="2018-04-25" version="1">MLTACGSNTGRDDGGAGGEPELAQWYHQYGEQGTEQAVKKYAAAYEKAHVTVQWRPGNYDEQTAAALLTDSGPDVFEVNGPTLDQIQGKQIADLTGLFEGVKDDFNPAVLAPKTYDGRIWAIPQVIDMQMLYYRKSLLADAGVEPPETLDELVDAAKKLTSKKTKGLFLGNDGGAGVLGGTPLYAAGLELVTEDGKVGFDDPAAARALGKIHQLYAGKSLLLGAPSDWSDPSAFVQGLTAMQWSGLWALPTVQKELGDDFGVLPFPKDGAGRPSVPVGAYGAAVSTRGEHQQAAKDYLRWLWIDRTEYQEDFALSYGFHIPARISLAKKAAKLRKGAAADAVRFTTDHGFAQPLRWTPASQTAYQDALSRIIKDGASPDSELKGVVRKVSAELDRVKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K1L9</accession>
    <name>A0A2M9K1L9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">SigE family RNA polymerase sigma factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CG723_07390</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CB01635</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000002">
        <property type="protein sequence ID" value="PJN13023.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN13023">
        <property type="protein sequence ID" value="PJN13023"/>
        <property type="gene ID" value="CG723_07390"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050896">
        <property type="term" value="P:response to stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039425">
        <property type="entry name" value="RNA_pol_sigma-70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014325">
        <property type="entry name" value="RNA_pol_sigma-E_actinobac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013249">
        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43133">
        <property type="entry name" value="PTHR43133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08281">
        <property type="entry name" value="Sigma70_r4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02983">
        <property type="entry name" value="SigE-fam_strep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="5">
        <location>
            <begin position="45"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4_2" evidence="6">
        <location>
            <begin position="123"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PJN13023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="203" mass="22413" checksum="11C4B1D2FCD51244" modified="2018-04-25" version="1">MDAGREAPAGYAGQTAGEAGADRWDSFREFVASRSSALLRTAVLLSGGDRHAAEDLLQNALIKAAGRWHRIDEPEAYVRKILYRQQISRWRLKWRGRELTVAEPPESRTGVDSSHAADLRIVMRTALARLTARQRTVLVLRYFEDLPEADVARLLGCSVGTVRSTTHRSLAKLRSLAPELAALGPADAEGLPSRDFSPMEVRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K1P3</accession>
    <name>A0A2M9K1P3_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF4115 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CG723_00040</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000001">
        <property type="protein sequence ID" value="PJN13039.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN13039">
        <property type="protein sequence ID" value="PJN13039"/>
        <property type="gene ID" value="CG723_00040"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025194">
        <property type="entry name" value="DUF4115"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13464">
        <property type="entry name" value="DUF4115"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="136"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4115" evidence="3">
        <location>
            <begin position="216"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="161"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PJN13039.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="292" mass="31084" checksum="E9BB891B27E9241C" modified="2018-04-25" version="1">MSIGNSPEDDRPSDDLHATPPPAVEQVPTPADDRPSIGRVLRQGRVDAGMTVDEVSTSTRVRVPIVHAIEEDDFSRCGGDVYARGHIRTIARAVGIDPEPLLAQFADEHGGRPAPTPAAPLFEAERIRSEPRRPNWTAAMVAAIVAVIGFVGFTAFGGSDDGAKQQAAEGATPATGKPKPTQTPKANKPTDPKPDPTDSAIAAAPRDKVTVKINAADGRSWISAKDHNGRIMFDGLLEQGESKTFQDNQKVDLVLGDAGAIQLYVNGKQVDNEFEPGQVERLTYTKGDPEVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K2D3</accession>
    <name>A0A2M9K2D3_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 12">Coproporphyrinogen III oxidase</fullName>
            <ecNumber evidence="6 12">1.3.3.15</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">hemG</name>
        <name evidence="14" type="ORF">CG723_01220</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">CB01635</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3 12">Involved in coproporphyrin-dependent heme b biosynthesis. Catalyzes the oxidation of coproporphyrinogen III to coproporphyrin III.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>coproporphyrinogen III + 3 O2 = coproporphyrin III + 3 H2O2</text>
            <dbReference type="Rhea" id="RHEA:43436"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:57309"/>
            <dbReference type="ChEBI" id="CHEBI:131725"/>
            <dbReference type="EC" id="1.3.3.15"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="1">
            <dbReference type="Rhea" id="RHEA:43437"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 12">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4 12">Porphyrin-containing compound metabolism; protoheme biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="12">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 12">Belongs to the protoporphyrinogen/coproporphyrinogen oxidase family. Coproporphyrinogen III oxidase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.3.15" evidence="6 12"/>
    <dbReference type="EMBL" id="NNBL01000001">
        <property type="protein sequence ID" value="PJN13240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN13240">
        <property type="protein sequence ID" value="PJN13240"/>
        <property type="gene ID" value="CG723_01220"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00252"/>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004729">
        <property type="term" value="F:oxygen-dependent protoporphyrinogen oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006783">
        <property type="term" value="P:heme biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002937">
        <property type="entry name" value="Amino_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004572">
        <property type="entry name" value="Protoporphyrinogen_oxidase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01593">
        <property type="entry name" value="Amino_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00562">
        <property type="entry name" value="proto_IX_ox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 12" id="KW-0274">FAD</keyword>
    <keyword evidence="8 12" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="11 12" id="KW-0350">Heme biosynthesis</keyword>
    <keyword evidence="10 12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amino_oxidase" evidence="13">
        <location>
            <begin position="23"/>
            <end position="463"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00002185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00008310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012402"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00019046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU364052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF01593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="PJN13240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="488" mass="51093" checksum="BCEE264039875A96" modified="2018-04-25" version="1">MREADTGTGTGQAPRAVVIGGGIAGLAAAHRLLAAGAQVTVLEASGRLGGKLRAGEIAGVRVDLGAESMLARRPEAVDLAREVGLGDRLQPPGTATASLWTRGALRPMPKGHVMGVPGTAAALSGVLSDEGLARIEQDRELPATEFGDDVAVGAYVAERLGREVVDRLVEPLLGGVYAGDAYRISMRSAVPQLFEEARSHRSLTEAVRAIQERAARNQQTGPVFMGIEGGIGQLPLAVADSVRARGGEILLDSPAHGLRRTPDGWEVRVDDRVIEADAVVLAVPAQQAAWLLDTESPAAAAELRTVEYASMALITLAFRRDEAHLPEGSGFLVPPVDGHTIKASTFASNKWGWIAAEDPGLVVVRTSVGRYQDEKDLARDDDGLVEVSRHDLREATGLSATPVATRVTRWHEGLPQYPVGHHARVARIRGHVAKIPGLAVCGAAYDGVGIPACVASAYAAVDQLDGDLTGVEELTANPVQSLHGGAGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-05-25" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K363</accession>
    <name>A0A2M9K363_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Sugar ABC transporter substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CG723_03100</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000001">
        <property type="protein sequence ID" value="PJN13562.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN13562">
        <property type="protein sequence ID" value="PJN13562"/>
        <property type="gene ID" value="CG723_03100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025997">
        <property type="entry name" value="SBP_2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13407">
        <property type="entry name" value="Peripla_BP_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014909421" evidence="2">
        <location>
            <begin position="38"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="domain" description="Peripla_BP_4" evidence="3">
        <location>
            <begin position="55"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="28"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="35"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PJN13562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="347" mass="36658" checksum="BFA87164CEAD5B7B" modified="2018-04-25" version="1">MPETTSRRGLLFGAAAAVTTGGLLTACTSNEPKDAKPAANDKPAADDKPGKHVTIGFAGPQADHGWLNAINDNATERAKKYSDVTLEATEGSNDTAAQIGQVETLINKKVDVLVILPADGKALTQVGLKAMRAGIPVVNLDRIFNTPQAYRCWIGGDNYGMGLSAGNYIGEQLKDKKNAKVVELAGLDNLELTKQRSQGFDDALKNFPNIKKVARQAAEFTVESGQAKMSQLLQAQKNFDALWNHDDDQGVGALRAIKQAGRDDFLMVGGAGALSAMQAIEAGNSVLKATVLYPPTMAASAIDLARALGQGKGVSGMAEFEIPAHVTLFSAVVDKDNVAQYMPTGFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-09-29" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K393</accession>
    <name>A0A2M9K393_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_03305</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000001">
        <property type="protein sequence ID" value="PJN13598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN13598">
        <property type="protein sequence ID" value="PJN13598"/>
        <property type="gene ID" value="CG723_03305"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="20"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="539"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="59"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="642"/>
            <end position="656"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN13598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="1481" mass="159785" checksum="623687F6310A3FCC" modified="2018-04-25" version="1">MTGTGRVPTAREWAEALWLAERIGTDAPPGEAPQDAPRVPPATEALAPPGGDSELLPEAPGPRPHREEPYGSEYGPDAETGSPGPTYGFGFAPGPAPDVFDADTRPGVLRSPQRLARALRPFNRRVRDRHRQTLDEEATAERAAELGQWSPVLTGVPDRWFEVALVVEQSVSMSVWQGVARELFTLLQRQGAFADLRIWRLDTGDGKSAVLRPEGGGARRGPAELFHPEGRRLILVLSDCVGDAWAGGAVPRLLHTWARRAPVAVLQPLPARLWDLCEGVPLDLRLRGAAPGMPNARLQLRRRGRWTRPCDTGGPVPVPVLELEPSWLAGWVRLVTGEATPWCEAAVLLVDDQGLDPECLPPFPWEERRRPVPPDQAVRRFQHFASPAARRLAARLAMVPLQPTVVDAVRRQVTRVAGPLPFAEILLGGLLSLRPERAGTGVAEPAYEFLDGVRGRLLRGLGRTEILRMLHEVTAVAGRVTGARPGLLGTLVASPAGLDGAELSGPDRELLEAARGALTALGPSYQEALDRVVPPRSFVAWPGGEETQGSGAPRPVPADDSRPVPPGGDVAPTRAQQPGTADPNTEEEPVDPTASPLGQAPLETERPGAKAPDGADANGAAADSGSSGGGSGPGDGSAGVVPPRGPRPPGGPARLPRSMPLPNAHFAGREDELHALRRLLGGGGQAAVLPQALYGLGGVGKTRLAIEYIHRHHQEYERVWWIDAEQPSVIREQLASIAPELGAAAEGPGDVVDRVLAALSAGTPYKRWLLVMDNAGSPEEVTPYIPSLLGVPDGVGHVLVTSRRSGWADRVRALRVDVFSREESIGFLRARTPWTSQDEAERLAESLGDLPLALEQCAALQTQTGIAAQDYLEMIENRMPELLAEPTVSGAQPVAAVFRATMEALREQHPGALELLRLFAFFGPEPIAQSFLHDARLLQLPGPLAAVARDPLERGRTIRAINQFSLLTVNSAAGTVQLHRLLRGVLQDELTEDERTTMRHLAHRVISAHDPGDSQRPEHWRNYAEILPHIEPSGLLDSEDRDTRATVLGILGYLIARGDFRGAADLARRVADTWRVTLGPDDLQTLWTLRQQASAHWQLSEFAESRKINEDILARLRATVGDDHEYTLTVAGATAADLRAAGRFTEALALDEDAYERSVRLYGAGEPYTLRVGHNYGVSLRVNGLYAEALALDQQVYGDRVTALGATARSTLFSVNNVARDMRECGRYAEALTLQERTLQQYREQYGDDHPHTLRAVKNMSVTCRKAGEFERGLALAQQVLGLYRTHFGPRHIDTLAALTNLSNDLRLTGDPQAARQAAASALVDYRAILGEAHPLTSTAAVNHGAALRAAGEPAEALRLDRSTVAVLARAVPDNHPWLLLARINLATDLTRAGEHDRARALGSDTAAKLEARYGDRHPSVLAALRNLALDMTASGDTQEGADLLASVRRRYLDTLGSEHPESRDAAAGIRAECDIEPPPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K3T3</accession>
    <name>A0A2M9K3T3_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">APH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_03865</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000001">
        <property type="protein sequence ID" value="PJN13687.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN13687">
        <property type="protein sequence ID" value="PJN13687"/>
        <property type="gene ID" value="CG723_03865"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="APH" evidence="1">
        <location>
            <begin position="122"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN13687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="259" mass="28677" checksum="58B70D8E0F5A8C7C" modified="2018-04-25" version="1">MIEDGGTDQGTVTTVQRVGDTIRRPPGRWTPLVHALLAHLEAAGFHGAPRVLGFDEDGREVLSLLHGEPGMNPWGPALQGAVGLRQLGRWARDYHEAVRGFRPPQDAEWFAPDARWRPGLIVRHGDLGMWNSVWSGDRLAGFIDWDFVEPGEPVDDLAQLAWYAVPLRDAGVQARCGFPDGAPVHERFLGLCEAYGGDIGPDAVLAALDRMQVREAARIREQGGHGRAPWNLMLRRGDAEEIDAERRWLARNKVVLLGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JEI7</accession>
    <name>A0A2M9JEI7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA mismatch repair protein MutT</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_45530</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000056">
        <property type="protein sequence ID" value="PJN05310.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN05310">
        <property type="protein sequence ID" value="PJN05310"/>
        <property type="gene ID" value="CG723_45530"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="SSF55811"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="1">
        <location>
            <begin position="60"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN05310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="205" mass="22880" checksum="3A0E927B84EBDDDE" modified="2018-04-25" version="1">MTSPDRQLTTPDDQSRGHLLELVGAIEPWDDLERTHLKTATQWIAGGAPVYRVRKPDVPARHLVSYFVVLDESCGQLLLVAHRKAGLWLPAGGHVEPGEDPWAAVARECREELGIEAVASPITGEHPLFLTVTETRGQGAHTDVSLWYLLTADADTITSYDQGEFNAIRWLTDEQVLEESDELLDPHMHRFTHKLQHARAGRHCG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JEW7</accession>
    <name>A0A2M9JEW7_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HTH cro/C1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_44980</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000049">
        <property type="protein sequence ID" value="PJN05419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN05419">
        <property type="protein sequence ID" value="PJN05419"/>
        <property type="gene ID" value="CG723_44980"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004155">
        <property type="entry name" value="PBS_lyase_HEAT"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01381">
        <property type="entry name" value="HTH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00567">
        <property type="entry name" value="EZ_HEAT"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="SSF48371"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="4"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN05419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="767" mass="84094" checksum="561BF6561A35C5EA" modified="2018-04-25" version="1">MTGRRLRQSDLAERAGVSPATVSNVFNLKSVPTVDTLDLLAHAVGITGTDLQQLHSLRERADGRTRRLDSYLAAALSAARDHPYAGVLPGVTPPLQTVYVRQQVQQRSGTPDPRALAHTADQRSVPAESVLAVDVTCVVVAGPGGGKTSLLRTWVAESAKSWLTGHGGGTVPVLVDAADLHGAALADAVACAVSKEMVEALPPRFFAAPPQQGVRWQILIDGLDEVTDLHARRDLLRRLAAVSEGPYADLYRFVIATRPLPPGELTQFGDHFPRYDLLPFDRRHLPEVATAWFGAVGHPSPGQAADRFIKALERTQLTSIARNPLMTAMLCQLHAATPEQPLPTGRAGIYRRFIALLHARQYSPRTTNAAAELCAGLARYGPAVLESANRVLDRLPDLIGFLAVERHHGNGQPTLDIVQRPSYTQVPRRVPEGDWRAFLDTALRRSGLLTRRGNDLVFLHQTLREYLAAQFLARNEQAARRALDDVFTVVADSNQFPPVLQAGLSYAGFLLEEVDHEDLLNTEDEKGRTAQRQLRRRVRYVLEIPFFIADLVVLGSNIPADLVSEAINHLAKIARTDALEWYWRDLAARALTRLGDKRGAEALEDLARDLRAHAQRRQVARRALYQFGDARSVEALYTLTADTGIGDSQFSAIKALLQFGSDAGREALQALSTDSRLGRHRVEAARALCKAGDPRGVEELAVLAHDAGLGWHRVEAARLLAGFGDARGVDILRHLAHGHDPNVDERGRMDAARSLAVYAPRFRNREP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JEX3</accession>
    <name>A0A2M9JEX3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_44690</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000048">
        <property type="protein sequence ID" value="PJN05450.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN05450">
        <property type="protein sequence ID" value="PJN05450"/>
        <property type="gene ID" value="CG723_44690"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="555"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="753"/>
            <end position="786"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN05450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="804" mass="85065" checksum="FD1FA155C0B18760" modified="2018-04-25" version="1">MNRWRRKPERAPESHSSRSDDGPGTPDGAAMASGTRSIAATRDIGVATTGDYSPVTVVMHQLAPMPNVLASLPAAPTMLSGRETEVARILSALRPVISRQPGPDPSSRSGPAAAALGQDAFPPVLVASIGGLAGVGKTALALTAGQAATKAGYFDGSLFIDLHGYDENPVQGGQALEAFLRALGVAHDAVPEAVEERAALYRTELAALAGQGRRLLIVADNASSAGQVRLLLPGNGMHRLLVTSRHTMATLNARLLDLGVLGSQAAVALLRHALLTADPTDRRVTEAGTALEELASLCGRLPLALHISAALLILEPCRTIAELNAELATAQSRLSFLDDGERAVRASFDLSYRRLPPDHAALFRLIALNPGPDIGLGAAAVLADLPLPAVRIVLRSLVQAHLLDCANQRWSMHDLVRDYASELAHSISNPPQHTAAEEAGQEAATEQARRHRRLLEHYATTTVAACARLGVQATPPAPGDFADRNEALAWLDYERANLTRSVAAAADAGHHDIAVNLPVALYDYLTWRGYYDDLISVTKTACRIAHQSGALAAEAGAWNNLGIALSEASRYEEAFRAYDRALELFTSLDNDNERGKVPNGRGLALRESGTPAEALRAHQEAVAIQRVTGDLREQAAALNNLSLAHQDLEDYAEACAAAESAASLFQRLGDTADEASALCTMAFALQAWGKPEDARAACRRALTASRAAGNPLIEAATLMTCAQLDNLTPQQQIEYLLQAETACEQANVAELRAAALSGIGVALTTAGKRDQAVTYFRRAQSLLEELGLTVQAAEVGEEIASLQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-09-29" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JEX5</accession>
    <name>A0A2M9JEX5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">AAA family ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_44735</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000048">
        <property type="protein sequence ID" value="PJN05456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN05456">
        <property type="protein sequence ID" value="PJN05456"/>
        <property type="gene ID" value="CG723_44735"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020591">
        <property type="entry name" value="Chromosome_initiator_DnaA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028350">
        <property type="entry name" value="DNAC/ATP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002611">
        <property type="entry name" value="IstB_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01695">
        <property type="entry name" value="IstB_IS21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF003073">
        <property type="entry name" value="DNAC_TnpB_IstB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00051">
        <property type="entry name" value="DNAA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="IstB_IS21" evidence="1">
        <location>
            <begin position="22"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN05456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="263" mass="29301" checksum="06DCF472D316E05C" modified="2018-04-25" version="1">MTMPRQRGLTEQAADAAIDSACRLLRLPSIRNEFSDIADRAIKDQMTYRGFLAELLMAECDDRARRRSERRIKAAGFPREKSLRSFDFDANPNIDPATIHTLASCEWIKKSQPLCLIGDSGTGKSHMLIALGTEAAMKGYRVRYTLATKLVNELVEAADEKQLNKTIARYGRVDLLCIDELGYMELDRHGAELLFQVLTEREEKNSVAIASNESFGGWTKTFTGPRLCAAIVDRLTFNGTIIETGTDSYRLASTRAQAERAAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JEY4</accession>
    <name>A0A2M9JEY4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_44730</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000048">
        <property type="protein sequence ID" value="PJN05455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN05455">
        <property type="protein sequence ID" value="PJN05455"/>
        <property type="gene ID" value="CG723_44730"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005114">
        <property type="entry name" value="Helicase_assoc"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03457">
        <property type="entry name" value="HA"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HA" evidence="2">
        <location>
            <begin position="24"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="domain" description="HA" evidence="2">
        <location>
            <begin position="92"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="domain" description="HA" evidence="2">
        <location>
            <begin position="257"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="139"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN05455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="334" mass="38100" checksum="600150BD8C002EF4" modified="2018-04-25" version="1">MHPGSHASRTPRQTTPQEVVIATREHGDLRVPFTYRVPAGQDAVAQGWLASLANFPLGQWTVDARRFYARGNMDQDRAVQLENLGMIWSHFDVAWEEGLTAARGWAAEHGHLLAPLDATHQGYRIGIWLKNQRAAARKAAQTEQRRAQGLPAESSAGALSQERREQLEEIDPSWCPTWPVEWQRAFHLTRQHLDKAGSLPTQPGDVMHQGEDLGRWVQAQRLGWDRLTTVQQWMCEQVLGITPASEEVKPKPRRTQADKWALNYEAARQFYEREGHLRVPRKHVERIVVGDEDSEDQEERELRLGAWIGNQRSRAATLSPERVEQLSAIGMRWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JF83</accession>
    <name>A0A2M9JF83_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DNA-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CG723_44815</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000048">
        <property type="protein sequence ID" value="PJN05463.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN05463">
        <property type="protein sequence ID" value="PJN05463"/>
        <property type="gene ID" value="CG723_44815"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PJN05463.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="185" mass="20916" checksum="BBB4870EBD5F9B93" modified="2018-04-25" version="1">MGEIEDAITRADREAFTKEPPKTLQGRINFLMKQLKTTRAVAAELGVSQRSVERYRKGERKHPPKDIAAKIDEAVRSRWQPQVRKRRRKQAAATSGVTVETRARFGYTAPVGTTDDGRFRRLTVHLPPAYAQRLFDAREAGASDQQMRGIIAEGFKEVYFQDGGGRAMGLSDVEINDIDYLDLDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JFE3</accession>
    <name>A0A2M9JFE3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Ester cyclase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CG723_43620</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000044">
        <property type="protein sequence ID" value="PJN05594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN05594">
        <property type="protein sequence ID" value="PJN05594"/>
        <property type="gene ID" value="CG723_43620"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030638">
        <property type="term" value="P:polyketide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009959">
        <property type="entry name" value="Cyclase_SnoaL-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38436">
        <property type="entry name" value="PTHR38436"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07366">
        <property type="entry name" value="SnoaL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="SSF54427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PJN05594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="135" mass="14543" checksum="52AFB115A9E94A96" modified="2018-04-25" version="1">MSQQDNIAAQTAFGEAVNSGNLAAIVDIVAPGSIDHDAALGQGPGPEGYQAMFRDLRRAFPDLHVEVERLLATEDELAFAYTITGTHRGELAGHAPTGKSVSFRGMQISRFEDGKLVERWASSDELGMMRQLGLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JFG8</accession>
    <name>A0A2M9JFG8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA primase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_43295</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000043">
        <property type="protein sequence ID" value="PJN05641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN05641">
        <property type="protein sequence ID" value="PJN05641"/>
        <property type="gene ID" value="CG723_43295"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025048">
        <property type="entry name" value="DUF3987"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13148">
        <property type="entry name" value="DUF3987"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="488"/>
            <end position="515"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN05641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="515" mass="55242" checksum="200B014492924A5B" modified="2018-04-25" version="1">MDSPDLWAGLPTLEEVPGEDEAAPDVWEDPIPLTGRRERPAFPAHVFPAWLGEFVSAVAEETQTPVDLAGSIALAVLATAAGGRSVVHVRGNWREPTNLFTVVALPPGNRKSAVFSLLTDPLYEAEKQLKSAMKPRIVEAELTARLAQEAADKATAKAASADGDKRDEMVATAIGLAQTADTLTVPAEPVLLADDSTPETVTSLMAEQGGRLSVMSDEGGIFDIIAGRYSGSPNMEVFLKGHAGGRLRVNRQTRREYIDAPALTMGLAVQPDVLLDIGKIKGAKGRGLLGRFLYSLPMSTVGDRKVITDPVPEQTAATYTARVIDLTLSLADWTDPAIIQLAPEADAALIAYQERVEPWLKSRGGRLGHIADWAGKLVGATARMAALLHLAEHGGNAYAHPVTEDTVHTAIELGEYYTAHALAVFDAMGADPVVGRARSVLEALRDNGWEDVSRRDVFTVLSRSEVPTVADLEPALALLEEHGYVRSYQPERTGKRGRPPAPRLVAHPTLRQGGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JFK6</accession>
    <name>A0A2M9JFK6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">LysR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_43415</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LysR transcriptional regulatory family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000043">
        <property type="protein sequence ID" value="PJN05664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN05664">
        <property type="protein sequence ID" value="PJN05664"/>
        <property type="gene ID" value="CG723_43415"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005119">
        <property type="entry name" value="LysR_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000847">
        <property type="entry name" value="Tscrpt_reg_HTH_LysR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00126">
        <property type="entry name" value="HTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03466">
        <property type="entry name" value="LysR_substrate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00039">
        <property type="entry name" value="HTHLYSR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50931">
        <property type="entry name" value="HTH_LYSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH lysR-type" evidence="2">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN05664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="298" mass="31750" checksum="40E5EFC1C0381885" modified="2018-04-25" version="1">MTLDDLRVYVAVCAAGSLSAVARDLSCTQSAVSQHIRRLEREVGVSLLERHARGVLPTAAGRILQTAAAEGIGGIDVALRRLRDLARGERGAVRVTTGATTVRHFMSGAIVGFRRRHPQASLEFQTVSSSHSAYEALAAHDLDLAWVTIGAPERGVEQRPVVELPWVLAVRPDDPLAGRTRIGPGDLAAAHLIRPPEQSTSRSHLDRHFSGLGIVRPAGSDAGVADWATAVHLAELGLGHALVPELPGWRDPDRAGGPVLVPVPDLPPLAVGWAVRRWSTLTPLARAFADLVAEHCGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JFN0</accession>
    <name>A0A2M9JFN0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Antibiotic biosynthesis monooxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_43575</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000043">
        <property type="protein sequence ID" value="PJN05691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN05691">
        <property type="protein sequence ID" value="PJN05691"/>
        <property type="gene ID" value="CG723_43575"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN05691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="130" mass="14223" checksum="661BA680C68C40FD" modified="2018-04-25" version="1">MSDHGVAPVGPEGSSGPASTVRPVPVFEPPYYAAVFTSVRTPGDNGYGATAERMSELVREIPGFLGEDSAVSEGGLRITVAYFRHEEGLKEWAGNGEHREAQRRGRAEWYESYSLHVAKVERSHGFERGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-05-25" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JFU0</accession>
    <name>A0A2M9JFU0_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Cytochrome c oxidase subunit 1</fullName>
            <ecNumber evidence="9">7.1.1.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">ctaD</name>
        <name evidence="11" type="ORF">CG723_42780</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CB01635</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6 9">Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7 9">
            <text>4 Fe(II)-[cytochrome c] + 8 H(+)(in) + O2 = 4 Fe(III)-[cytochrome c] + 4 H(+)(out) + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:11436"/>
            <dbReference type="Rhea" id="RHEA-COMP:10350"/>
            <dbReference type="Rhea" id="RHEA-COMP:14399"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="EC" id="7.1.1.9"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 9">Energy metabolism; oxidative phosphorylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cell membrane</location>
            <topology evidence="9">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the heme-copper respiratory oxidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.1.1.9" evidence="9"/>
    <dbReference type="EMBL" id="NNBL01000041">
        <property type="protein sequence ID" value="PJN05765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN05765">
        <property type="protein sequence ID" value="PJN05765"/>
        <property type="gene ID" value="CG723_42780"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00705"/>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070469">
        <property type="term" value="C:respirasome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004129">
        <property type="term" value="F:cytochrome-c oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015990">
        <property type="term" value="P:electron transport coupled proton transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006119">
        <property type="term" value="P:oxidative phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.210.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023616">
        <property type="entry name" value="Cyt_c_oxase-like_su1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036927">
        <property type="entry name" value="Cyt_c_oxase-like_su1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000883">
        <property type="entry name" value="Cyt_C_Oxase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023615">
        <property type="entry name" value="Cyt_c_Oxase_su1_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014241">
        <property type="entry name" value="Cyt_c_oxidase_su1_bac"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10422">
        <property type="entry name" value="PTHR10422"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00115">
        <property type="entry name" value="COX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01165">
        <property type="entry name" value="CYCOXIDASEI"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81442">
        <property type="entry name" value="SSF81442"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02891">
        <property type="entry name" value="CtaD_CoxA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50855">
        <property type="entry name" value="COX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00077">
        <property type="entry name" value="COX1_CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-0186">Copper</keyword>
    <keyword evidence="8" id="KW-0249">Electron transport</keyword>
    <keyword evidence="8" id="KW-0349">Heme</keyword>
    <keyword evidence="9" id="KW-0408">Iron</keyword>
    <keyword evidence="5 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="40"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="79"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="121"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="168"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="205"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="251"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="287"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="314"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="357"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="390"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="427"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="469"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="domain" description="COX1" evidence="10">
        <location>
            <begin position="28"/>
            <end position="534"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00025218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00029368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU363061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50855"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PJN05765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="568" mass="62934" checksum="2E6DA83015DA1E9A" modified="2018-04-25" version="1">MGTTDVQPVQPAPGAARTKTPGRIVVEWLTTTDHKKIGHLYLITSFAFFLAGGVMALLMRAELARPGLQMLSNEQYNQLFTMHGTIMLLLFATPTFAGFANEIMPLQIGAPDVAFPRLNMFSYWLFLFGGLIVIGSLMVPGGAADFGWFAYAPLNSLTRSPGIGADMWIMGLALAGFGTILGAVNFLTTIIGMRAPGMTMFRMPIFTWNTLFTSILVLMAFPVLAAALLVLEADRRFGAVVFEAQFGGALLWQHLFWFFGHPEVYIIALPFFGIVSEILPVFSRKPIWGYSMLVGATMAITGLSIVVWAHHMFVTGGVLLPFFSFMTFLIAVPTGVKFFNWIGTMIKGSLSFETPMLWSVGFLVTFLFGGLTGVILAVPPLDFHVTDSYFVVAHFHYVVFGTVVFATFGGFYFWWPKFTGKMLDERLGKIQFWTLFVGFHTTFLVQHWLGAEGMPRRYADYLAVDGFTALNTLSTIGSLLLGFSTLPFLYNVWKTARYGEKVDVDDPWGYGRSLEWATPCPAPRHNFLTLPRIRSESPAFDLHHPAFASARPLSRPVPVPGTDGPERS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JG72</accession>
    <name>A0A2M9JG72_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Sugar ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CG723_42415</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CB01635</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000039">
        <property type="protein sequence ID" value="PJN05891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN05891">
        <property type="protein sequence ID" value="PJN05891"/>
        <property type="gene ID" value="CG723_42415"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="93"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="125"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="151"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="201"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="260"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="89"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PJN05891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="293" mass="31517" checksum="E1D09CFD24376D84" modified="2018-04-25" version="1">MTALDTSVRAKRSLAARIASGAAGGALRAFLLVVGLFWLVPTFGLLVSSFRDPTDIAASGWWKVFTAPAQLTTKSYQTLLEKDEITHALFNTIWITVPATLLVVIIGSMAGYAFACMDFKGRDGWFMAVVGLLVVPVQVALIPLSELFGKIGIFGSIIGVILFHVGFGLPFAIFLLRNFFAEIPRELLEAARLDGAGEARLFATVVLPLGGPAIASLGIFQFLWVWNDMLVALIFSDSGSQPLTVALQQQVRQFSGNIEILAPGAFISMVIPLAVFFAFQRQFVSGVMAGAVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JGB7</accession>
    <name>A0A2M9JGB7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">2,3-dihydroxybenzoate-AMP ligase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_42125</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000038">
        <property type="protein sequence ID" value="PJN05929.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN05929">
        <property type="protein sequence ID" value="PJN05929"/>
        <property type="gene ID" value="CG723_42125"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-binding" evidence="1">
        <location>
            <begin position="32"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding_C" evidence="2">
        <location>
            <begin position="451"/>
            <end position="527"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN05929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="550" mass="59996" checksum="6B48994BA8799B34" modified="2018-04-25" version="1">MLDGCVPWPEELASRYREAGYWRGETLGALLRRWADEYGDREALVSADGRRRITYRALDEWCDRLAAGFAARGTAPGDRVLVQLPNTPDFVAVCFALFRLGALPVFALPAYRDNEIRHLAELSGASAYIVPDTFNGFDHRDLARSMQEQLPQISQVFVAGDPGVPREGCTALADVDAEPVDLPGPDASDVAFFLLSGGTTALPKLIPRTHDDYAYQTRITGDICGLDSSTVYLAVLPVEFNFPWGCPGIIGTLRVGGRVVFAETPQPLACFPLIERERVTLTSVIPTIVHLWLAAVEEGHEHDLSSLDVLQVGSAKLHDEVAARIEPLLGVRLQQVFGMAEGLLTFTRYDDPHDTILTTQGRPVSPADEIRVVDTDGADVPLGGIGELLTRGPYTLRGYYRAPEHNERAFTEDGFYRSGDLVRRTAGGEIVIEGRVKDVVIRGGDKVSATEIEGHLTAHPDVQQAAVVAMPDPVLGEKVCAYVIAAPGRPAPKLPVLRELLRSRGLASYKLPDRVEAVGTFPLTGLNKVDKKVLRARIADKLERLAREAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JGL6</accession>
    <name>A0A2M9JGL6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Polyprenol monophosphomannose synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_42300</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000039">
        <property type="protein sequence ID" value="PJN05897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN05897">
        <property type="protein sequence ID" value="PJN05897"/>
        <property type="gene ID" value="CG723_42300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004582">
        <property type="term" value="F:dolichyl-phosphate beta-D-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06442">
        <property type="entry name" value="DPM1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039528">
        <property type="entry name" value="DPM1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43398">
        <property type="entry name" value="PTHR43398"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glyco_trans_2-like" evidence="1">
        <location>
            <begin position="1"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN05897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="234" mass="25457" checksum="CF2ECB85687A1969" modified="2018-04-25" version="1">MPTYNEAGNLPGMADALMALPLPGLRLLVVDDSSPDGTGDIAERYAERHGHDRMSVLHRAGKEGLGRAYAAGMARAVADGARYVLQMDADGSHPTDKVPALLGTALATGAAVTIGSRYVQGGTLSEAWGVHRRLLSRWANTYAGTILGTRVRDITGGFNLWREDALRAIDLASVDSAGYSFQVEMKYRAVRRGFGVMEVPIHFEDRTVGESKMNLMVQLESVTMPWKLRARARR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-06-02" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JGV6</accession>
    <name>A0A2M9JGV6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_41580</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000036">
        <property type="protein sequence ID" value="PJN06083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN06083">
        <property type="protein sequence ID" value="PJN06083"/>
        <property type="gene ID" value="CG723_41580"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="24"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="37"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN06083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="147" mass="16070" checksum="31ECCA04F71A66C5" modified="2018-04-25" version="1">MGVDLELHASRPPRNWRKSRATLLRNSHGHGDALADALDGYVRESRRRSTRVGESRAHADSRCTREREWPRAAGQRLNQSPGGPRLPSGEGFSEGPAPDTRTPTTSARSHGAGRPSRRRQPPAPSPSAEYRPGVPGRRHHTSPATPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JH70</accession>
    <name>A0A2M9JH70_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DNA-binding response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CG723_40115</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000033">
        <property type="protein sequence ID" value="PJN06228.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN06228">
        <property type="protein sequence ID" value="PJN06228"/>
        <property type="gene ID" value="CG723_40115"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="3"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="domain" description="HTH luxR-type" evidence="3">
        <location>
            <begin position="148"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PJN06228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="221" mass="23941" checksum="27165F731E26325D" modified="2018-04-25" version="1">MIRVLLADDQSLVRAGFRALLDAQSDIEVAGEASDGDEAVRLVRELRPDVVLMDIRMPVLDGLAATRRISDDAALESVKVVMLTTFELDEYVFEAIRAGASGFLVKDTEPEELLRAVRAVVHGDALLSPGVTRRLIAEFAARSKEPAAAGSLGQLTEREREVMALVGIGLSNEEIARRLVVSPLTAKTHVSRTMVKLGARDRAQLVVLAYESGLVRPGWLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JHA0</accession>
    <name>A0A2M9JHA0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DeoR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CG723_40270</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000033">
        <property type="protein sequence ID" value="PJN06256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN06256">
        <property type="protein sequence ID" value="PJN06256"/>
        <property type="gene ID" value="CG723_40270"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014036">
        <property type="entry name" value="DeoR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001034">
        <property type="entry name" value="DeoR_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018356">
        <property type="entry name" value="Tscrpt_reg_HTH_DeoR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00455">
        <property type="entry name" value="DeoRC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08220">
        <property type="entry name" value="HTH_DeoR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00037">
        <property type="entry name" value="HTHLACR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00420">
        <property type="entry name" value="HTH_DEOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="SSF100950"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00894">
        <property type="entry name" value="HTH_DEOR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51000">
        <property type="entry name" value="HTH_DEOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH deoR-type" evidence="4">
        <location>
            <begin position="9"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PJN06256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="275" mass="28793" checksum="FF0D784DB18F5902" modified="2018-04-25" version="1">MSENQNLLAEQRRALILDEVRRRGGVRVNELTRKLGVSDMTVRRDLDALARQGVLEKVHGGAVPVEEASTHEPGFEAKSGLELSAKEDIARTAAALAAPGTAIALSGGTTTYALAHHLLDVPDLTVVTNSVRVADVFHGAQRSSGQRQGAATVVLTGGVRTPSDSLVGPVADQAIAALHFDVLFLGVHGISLEAGLSTPNLAEAETNRRLVQSARRVVVVADHTKWGTVGLSSFASLDQVDTLVTDAGLPADARAEISEELRLIIAGEPGTGTDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JHC5</accession>
    <name>A0A2M9JHC5_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Carbamate kinase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CG723_40200</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CB01635</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the carbamate kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000033">
        <property type="protein sequence ID" value="PJN06243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN06243">
        <property type="protein sequence ID" value="PJN06243"/>
        <property type="gene ID" value="CG723_40200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008804">
        <property type="term" value="F:carbamate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006525">
        <property type="term" value="P:arginine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04235">
        <property type="entry name" value="AAK_CK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1160.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036393">
        <property type="entry name" value="AceGlu_kinase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001048">
        <property type="entry name" value="Asp/Glu/Uridylate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003964">
        <property type="entry name" value="Carb_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023000">
        <property type="entry name" value="Shikimate_kinase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30409">
        <property type="entry name" value="PTHR30409"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00696">
        <property type="entry name" value="AA_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000723">
        <property type="entry name" value="Carbamate_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53633">
        <property type="entry name" value="SSF53633"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01128">
        <property type="entry name" value="SHIKIMATE_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 6 9" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="AA_kinase" evidence="8">
        <location>
            <begin position="9"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="312"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="329"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR000723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PJN06243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="343" mass="36003" checksum="08C5DE3F9689398E" modified="2018-04-25" version="1">MTPRAVPRTAVVAIGGNALLRGGTHATVAEQVEAARRLASPVVALADTGWRVVVTHGNGPQVGFIKRRAELAAALAPELPAVGLDMCVADSQGGLGYILATAIAGRLRSLGRADDRVAALITHTVVDAHDEAFSHPTKPIGAFCPAARARELADLHNWTVAEEGERGWRRVVPSPRPRRVLETEAVRALSSAGFTVIAAGGGGIPLVETDDGGYRGVEAVIDKDLTSAHLAAELGAELLVITTGVERVAVDYGRPTQRYLDRLTHDEAERLLAQGQFPPGSMGPKIRAALDFLRGAPGRQVLITSPRQLGAALDGRGGTRLDSEPARTTEEPLNGTVTAGRPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JHI7</accession>
    <name>A0A2M9JHI7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NADH:riboflavin 5'-phosphate oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_39970</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000032">
        <property type="protein sequence ID" value="PJN06322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN06322">
        <property type="protein sequence ID" value="PJN06322"/>
        <property type="gene ID" value="CG723_39970"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016646">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002563">
        <property type="entry name" value="Flavin_Rdtase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01613">
        <property type="entry name" value="Flavin_Reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00903">
        <property type="entry name" value="Flavin_Reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flavin_Reduct" evidence="1">
        <location>
            <begin position="21"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN06322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="173" mass="18549" checksum="A1EC9540C7A9D599" modified="2018-04-25" version="1">MTGLQEKTRPVVAPQAFRDAMALLAAPVSIVTALDPDGQRRGFTASSVTSVSLEPPLIMVGIALTSSCHATLTHAEEFVVNVLGEGHRALARRFATQDVDRFTGGGFAAWEGSGTPYLPDAALLVRCRTARIVRAGDHDLVLGTPAEIRPGAPAADPLLWYRRGFHTAREHRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JHW5</accession>
    <name>A0A2M9JHW5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_38685</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000029">
        <property type="protein sequence ID" value="PJN06475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN06475">
        <property type="protein sequence ID" value="PJN06475"/>
        <property type="gene ID" value="CG723_38685"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="42"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN06475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="77" mass="8147" checksum="4FF7D6CA00864B4A" modified="2018-04-25" version="1">MAKKAKNFKKSKTGAYVSIATTAFGAISVAKQAKLARNDHDTLRLIDAAVSAAAIVTGLAILYRELKRLGDDDVLLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JI21</accession>
    <name>A0A2M9JI21_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DNA-binding response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CG723_38935</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000029">
        <property type="protein sequence ID" value="PJN06518.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN06518">
        <property type="protein sequence ID" value="PJN06518"/>
        <property type="gene ID" value="CG723_38935"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00622">
        <property type="entry name" value="HTH_LUXR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="8"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="domain" description="HTH luxR-type" evidence="3">
        <location>
            <begin position="146"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PJN06518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="214" mass="22723" checksum="FB76DD70AFA08956" modified="2018-04-25" version="1">MTSDCVISLLIVDDHPVVRDGLRGMFESADDFTVLGEASNGVEAVELAARLDPDVVLMDLRMPGGNGVDAIKELTRRGARSRVLVLTTYDTDSDTLPAIEAGATGYLLKDAPREELFTAVRAAADGRTVLSPAVASRLVTAVRTPAAPADEPLSAREREVLALVAKGTSNKEIARVLFISEATVKTHLTHVYGKLGVKDRAAAVAVAYDRKILG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JI55</accession>
    <name>A0A2M9JI55_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Reactive intermediate/imine deaminase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_38415</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000028">
        <property type="protein sequence ID" value="PJN06576.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN06576">
        <property type="protein sequence ID" value="PJN06576"/>
        <property type="gene ID" value="CG723_38415"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035959">
        <property type="entry name" value="RutC-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006175">
        <property type="entry name" value="YjgF/YER057c/UK114"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11803">
        <property type="entry name" value="PTHR11803"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01042">
        <property type="entry name" value="Ribonuc_L-PSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55298">
        <property type="entry name" value="SSF55298"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN06576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="136" mass="14574" checksum="B13146265E890E8C" modified="2018-04-25" version="1">MTEKTALTPATHTTPPAKFSHGVKKGNILQVAGQVGFLPAVEGQAPTPAGPTLREQTLQTFANVKAILEEGGATWDDVMMMRVYLTDVDHFAEMNAIYNAYFEEQGLKAPASARTTVYVGLPKGLLIEIDALAVLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JIG4</accession>
    <name>A0A2M9JIG4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Aldehyde dehydrogenase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CG723_37910</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CB01635</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000027">
        <property type="protein sequence ID" value="PJN06660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN06660">
        <property type="protein sequence ID" value="PJN06660"/>
        <property type="gene ID" value="CG723_37910"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016620">
        <property type="term" value="F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="SSF53720"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00687">
        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldedh" evidence="4">
        <location>
            <begin position="13"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PJN06660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="462" mass="47690" checksum="CD085175060940D2" modified="2018-04-25" version="1">MKAHDGMYIGGEWRAAAGTDTIAVVDPADEQVIAHVPAGIAEDVDAAVFAAHEAFPAWAATPPAERAARIAALRDVLVARKDEIAETVTAELGAPLQFSQMVHAGVPILVAGSYAELAASYAFEEKVGNSTVYAEPVGVVGAITPWNYPLHQIVAKVAPALAAGCTVVLKPAEDTPLTAQLFAEAVHEAGIPAGVFNLVTGLGTVAGQALAAHPGVDLVSFTGSTAVGKQIGATAGAAVKRVALELGGKSANVILPSADLTKAVGVGIANVMGNSGQTCSAWTRMLVHTSQYDEAVTLAAEAAAKYGDRIGPLVNAKQHARVRGYIETGVAEGARLVAGGPEAPREQGYFVSPTVFADVTPEMTIAQEEIFGPVVSIIRYEDEDEALRIANGTVYGLAGAVWAADDAEAVAFARRMDTGQVDINGGRFNPLAPFGGYKQSGVGRELGAHGLSEYLQTKSLQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JIV5</accession>
    <name>A0A2M9JIV5_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">NADH-quinone oxidoreductase subunit I</fullName>
            <ecNumber evidence="5">7.1.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">NADH dehydrogenase I subunit I</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">NDH-1 subunit I</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">nuoI</name>
        <name evidence="8" type="ORF">CG723_37640</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CB01635</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a quinone + 5 H(+)(in) + NADH = a quinol + 4 H(+)(out) + NAD(+)</text>
            <dbReference type="Rhea" id="RHEA:57888"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="5">Binds 2 [4Fe-4S] clusters per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">NDH-1 is composed of 14 different subunits. Subunits NuoA, H, J, K, L, M, N constitute the membrane sector of the complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the complex I 23 kDa subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.1.1.-" evidence="5"/>
    <dbReference type="EMBL" id="NNBL01000026">
        <property type="protein sequence ID" value="PJN06798.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN06798">
        <property type="protein sequence ID" value="PJN06798"/>
        <property type="gene ID" value="CG723_37640"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050136">
        <property type="term" value="F:NADH dehydrogenase (quinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01351">
        <property type="entry name" value="NDH1_NuoI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010226">
        <property type="entry name" value="NADH_quinone_OxRdtase_chainI"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10849">
        <property type="entry name" value="PTHR10849"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00037">
        <property type="entry name" value="Fer4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="3 5" id="KW-0408">Iron</keyword>
    <keyword evidence="4 5" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0520">NAD</keyword>
    <keyword evidence="5" id="KW-0874">Quinone</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-1278">Translocase</keyword>
    <keyword evidence="5" id="KW-0830">Ubiquinone</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="7">
        <location>
            <begin position="42"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="7">
        <location>
            <begin position="91"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="173"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="51"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="54"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="57"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="61"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="100"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="103"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="106"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="110"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01351"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PJN06798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="207" mass="22510" checksum="4912F2D111F92AA4" modified="2018-04-25" version="1">MAPIPGAGLAKGLAVTLRTMTRKTVTEQYPDVQPELPPRTRGVIGLFEENCTVCMLCARECPDWCIYIDSHKETVPAAVEGGRERSRNVLDRFAIDFALCMYCGICIEVCPFDALFWSPEFEYAETDIHELTHERDRLREWMWTVPAPPALDPAAEEPKELAAARKAADKLAAAQAAAAQAPASEAPASASEEPAPDEPAPGEEGPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JIW0</accession>
    <name>A0A2M9JIW0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Histidine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CG723_37610</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000026">
        <property type="protein sequence ID" value="PJN06793.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN06793">
        <property type="protein sequence ID" value="PJN06793"/>
        <property type="gene ID" value="CG723_37610"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025828">
        <property type="entry name" value="Put_sensor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011712">
        <property type="entry name" value="Sig_transdc_His_kin_sub3_dim/P"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07730">
        <property type="entry name" value="HisKA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13796">
        <property type="entry name" value="Sensor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="42"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="67"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="135"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="199"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="domain" description="Sensor" evidence="3">
        <location>
            <begin position="44"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="domain" description="HisKA_3" evidence="2">
        <location>
            <begin position="260"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PJN06793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="449" mass="48271" checksum="3565E7C4F9439C6A" modified="2018-04-25" version="1">MITPTQYGQGHGYRDDAVAGERRHLLPAGLRAPFEGRTFREFGYLLLSLPISIITFVYAVTMVSLGAGLLITFLGIPVLAGALAGARGFAAMERARARALLGIDVGTPAPLRPRAHGPMAWMGALLKSGESWRNLLYTVVHFPWAVFAFNVALVFWTVGWSLLTYPLWQWVFPMYAGQGGIQLYGDGAHNVYLDNPFEITVTAAVGLLITLATPWIIRALASVDRALVSGLLGPSRLATRVVELESDRGVVVDTAAADLRRIERDLHDGAQARLVSLAMDLGLAKEKLTEDPRAAARMVDEAHGEVKTALQELRDLARGIHPAILTDRGLDAALSSLASRCTVPVQVEVDLPARPAPAIEGIAYFTVGELLQNVSKHSRATRATVDVWRVEDRLMLQVMDNGVGGADASAGSGLAGLAERLDAVDGILLVDSPTAGPTRITAELPWRRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-06-02" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JJ44</accession>
    <name>A0A2M9JJ44_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">LytR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CG723_37070</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CB01635</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LytR/CpsA/Psr (LCP) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000025">
        <property type="protein sequence ID" value="PJN06891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN06891">
        <property type="protein sequence ID" value="PJN06891"/>
        <property type="gene ID" value="CG723_37070"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004474">
        <property type="entry name" value="LytR_CpsA_psr"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03816">
        <property type="entry name" value="LytR_cpsA_psr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00350">
        <property type="entry name" value="lytR_cpsA_psr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="48"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="domain" description="LytR_cpsA_psr" evidence="4">
        <location>
            <begin position="127"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="369"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="374"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="395"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="421"/>
            <end position="444"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF03816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PJN06891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="453" mass="47879" checksum="C2FFD84D9F1A4CC9" modified="2018-04-25" version="1">MTDSAGTPPEPQHPGDDDAAGPVTHGPGAGSSPTGAGTARRHKRWLRYTAIGVGVAVLAAGGAGWAVYEKLQGNITEDTDAAAELARYEKERPTSLVAGAQNILLIGSDSRSGADNRKYGRDSGTQRSDTTILLHISADHKSAIAVSLPRDLMVDVPSCRAHGGTRTGPMFSMFNYAFEQGGSACTIRTVEKLTGIRINHHMVVDFSGFKDMVDAVDGVEVCLKEPMNDRAARLKLPAGKQTLDGEQALGFVRARKSLGNGSDTDRMDRQQQFLGALVNKVQSNQVLLNPTKLYPVLDAGTSSLTTDPGLASLRGLYNLVRGIRDIPTERVQFLTVPRRSYVYNANRDQLVQPAAEQLFTRLRTDAPVVVAKKTPRESTTQSSSDGSGTDSSGTDNRAYEHDGFDDGKGGADRSAQKPGGPSMPPGSSGSSPGSSPTPAPTFRGNTAAQDACG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JJ55</accession>
    <name>A0A2M9JJ55_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">GRAM_POS_ANCHORING domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CG723_36970</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000025">
        <property type="protein sequence ID" value="PJN06872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN06872">
        <property type="protein sequence ID" value="PJN06872"/>
        <property type="gene ID" value="CG723_36970"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019931">
        <property type="entry name" value="LPXTG_anchor"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50847">
        <property type="entry name" value="GRAM_POS_ANCHORING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0134">Cell wall</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0572">Peptidoglycan-anchor</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0964">Secreted</keyword>
    <keyword evidence="2 6" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014708929" description="GRAM_POS_ANCHORING domain-containing protein" evidence="6">
        <location>
            <begin position="25"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="409"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="domain" description="GRAM_POS_ANCHORING" evidence="7">
        <location>
            <begin position="399"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="155"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="305"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="376"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="203"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PJN06872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="438" mass="43254" checksum="EE54C8A52DE25EF8" modified="2018-04-25" version="1">MSAAGVALMLGGAGLLLAAAPAQAAEVAYKTECIPPPISGLPPVEGTTKVEITAPAEAKVGDEVEVVWKTTQAASSNPDVLDLEKDTVQPTGTVKVGGAQTADLAVEGTRTNPPIKKNSPMVLSDMKGKIKLTAPGEVTLTPDKYNINVSKPISTDTKCSPKETVKPGATIKVTDAGGATTGGLPTGLPTGLPTGLPTGLPTGLPTGGTSGGSSGTGGSDTGGSDTGGSGGGKSDFTGKEVQIPYKCKTPIGDKSATSPVQINAKKDGGNYGLTVQFKKSVMDSPADIPADSVKPSMEVKLGGADKGTVHVEGPTNKEPIKSGAPINIPDLTGTYKPGADGKSTLSPGVLTVKALGTTTTCTPSKTEVSLEIDTAAQPGGAAGGSGSGSAGGSDTSGGLAETGSSNDGILRALGLVAGTVILLGGAVFTFLPRRRRAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JJ80</accession>
    <name>A0A2M9JJ80_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CG723_36115</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000024">
        <property type="protein sequence ID" value="PJN06930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN06930">
        <property type="protein sequence ID" value="PJN06930"/>
        <property type="gene ID" value="CG723_36115"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PJN06930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="65" mass="7185" checksum="B488F9BBF6F7F58F" modified="2018-04-25" version="1">MPVFAAADQEELYKIVATDAHLAEGQVQEMTCTRWDPIFGVLGEESSRAGLSDAQLFERLAELTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-05-25" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JJD4</accession>
    <name>A0A2M9JJD4_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">OmpR/PhoB-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CG723_36415</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CB01635</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AfsR/DnrI/RedD regulatory family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000024">
        <property type="protein sequence ID" value="PJN06973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN06973">
        <property type="protein sequence ID" value="PJN06973"/>
        <property type="gene ID" value="CG723_36415"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd15831">
        <property type="entry name" value="BTAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041664">
        <property type="entry name" value="AAA_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005158">
        <property type="entry name" value="BTAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13191">
        <property type="entry name" value="AAA_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03704">
        <property type="entry name" value="BTAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01043">
        <property type="entry name" value="BTAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0902">Two-component regulatory system</keyword>
    <feature type="domain" description="OmpR/PhoB-type" evidence="5">
        <location>
            <begin position="13"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="3">
        <location>
            <begin position="13"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="524"/>
            <end position="552"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PJN06973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="552" mass="59325" checksum="C79C3B7337D903CD" modified="2018-04-25" version="1">MAPSISTDLPPLPPACDSALVRYRLLGQVRAERAGEPLPPGTPKQQALLAALLLRGGEQVERTELVRAVWGEHAPDSAAGLLATYTARLRKALEPDRARRAAPRLLITRGTTYGLHLRRDALDLWRFEDALSEARRERRAGRVGAARTCYERALAQWRGEQALSGVPERCAADARHRLAGLRLDVRLEHAEALLDLGEHAEAAERIAPLVPGRPYDERLQALLMLALYRSGRTPEALALFRGVRRALVHDLGVEPRPGLSRLHARILHADPSLAAPRQPPRSLTPACPAPAHRLPVPAQLPRDSADFTGREEEVRQLRELLRRPDSPAAVCPTVVISGAAGLGKSTLAVHVAHQVRDRFPDGQLYAVLGGRAPADVLGRFLEDLGVAPHEVPDGLERRAVRFRTLTAERRLLVLLDDAQSTNQLRELLPAAPGCAVLVTSQAPLRDLPGRVPLRLGPLDAAQSLRLLRRFASGAPLASVAALPYRSAATATATSALHSLADGCAGHPLALRLAAARAADEAARVDDIGGPPASHPGFPDGPRTARTRIASAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JJS5</accession>
    <name>A0A2M9JJS5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Anti-sigma regulatory factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_35410</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000023">
        <property type="protein sequence ID" value="PJN07027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN07027">
        <property type="protein sequence ID" value="PJN07027"/>
        <property type="gene ID" value="CG723_35410"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13581">
        <property type="entry name" value="HATPase_c_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HATPase_c" evidence="2">
        <location>
            <begin position="8"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="76"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN07027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="145" mass="15036" checksum="256044C1D9F970EA" modified="2018-04-25" version="1">MATVELRFSAQPEHVRTARLVAAAVARRAGVDEAVLDEVRLAVGEACSRAVGLHRSSGITAPVRVLLTEEEKQFSIEVGDEAPRSVPGEQSSGAPGGSDDLAAEGEDDMGLAVISGLVDDVEVTADESGGLIRMTWPTTPATLPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-06-02" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JJU1</accession>
    <name>A0A2M9JJU1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_35940</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000023">
        <property type="protein sequence ID" value="PJN07146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN07146">
        <property type="protein sequence ID" value="PJN07146"/>
        <property type="gene ID" value="CG723_35940"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN07146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="293" mass="31926" checksum="47C25333AA804D60" modified="2018-04-25" version="1">MNESSAKTASSKGSKGASAKGSSSKGTSSKGSSSKGTAKGSVPDEKGLDFARAWVEFPDPADDEQIFRCDLTWLTSRWSCIFGSGCQGIQAGRADDGCCTLGAHFSDEDDEKRVAGFVARLTPDIWQHHEVGTETGWVSKDEDGERQTRPYNGSCIFQNRPGFKGGAGCSLHILAIKEGREPLETKPDVCWQLPVRRTYEWIDRPDDTRVLQVSIGEYDRRGWGPGGHDLHWWCTSATSAHGAGDPVYVSYRPELTELMGKEGYDRLAELCEERLASQLPLLAPHPADPATAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JKX1</accession>
    <name>A0A2M9JKX1_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Inorganic pyrophosphatase</fullName>
            <ecNumber evidence="5">3.6.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Pyrophosphate phospho-hydrolase</fullName>
            <shortName evidence="5">PPase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">ppa</name>
        <name evidence="6" type="ORF">CG723_33465</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CB01635</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>diphosphate + H2O = H(+) + 2 phosphate</text>
            <dbReference type="Rhea" id="RHEA:24576"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="EC" id="3.6.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homohexamer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the PPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.1" evidence="5"/>
    <dbReference type="EMBL" id="NNBL01000020">
        <property type="protein sequence ID" value="PJN07513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN07513">
        <property type="protein sequence ID" value="PJN07513"/>
        <property type="gene ID" value="CG723_33465"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004427">
        <property type="term" value="F:inorganic diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006796">
        <property type="term" value="P:phosphate-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00412">
        <property type="entry name" value="pyrophosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.80.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00209">
        <property type="entry name" value="Inorganic_PPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008162">
        <property type="entry name" value="Pyrophosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036649">
        <property type="entry name" value="Pyrophosphatase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10286">
        <property type="entry name" value="PTHR10286"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00719">
        <property type="entry name" value="Pyrophosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50324">
        <property type="entry name" value="SSF50324"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Proton acceptor" evidence="5">
        <location>
            <position position="106"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="25"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="33"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="47"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="59"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="69"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="74"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="101"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="106"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="143"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PJN07513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="179" mass="20169" checksum="3A3C280A2D0FE847" modified="2018-04-25" version="1">MDNEVRHTDAAHGTDAAHAFDVTVEIPQGSRNKYEMDHSVGRIRLDRMLFTSTQYPADYGYIEDTLGRDGDPLDALVLVGDPTFPGCTVECRAIGMFVMRDEKGMDEKVLCVPAHDPRHASVQDIEDIPEFDRLEITHFFEVYKDLEPGKSAEGSHWEGRDLTYAEIAAARRRANGQRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JL42</accession>
    <name>A0A2M9JL42_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">30S ribosomal protein S18</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4 6" type="primary">rpsR</name>
        <name evidence="6" type="ORF">CG723_33060</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CB01635</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Part of the 30S ribosomal subunit. Forms a tight heterodimer with protein S6.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4 5">Belongs to the bacterial ribosomal protein bS18 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000019">
        <property type="protein sequence ID" value="PJN07596.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003949403.1">
        <property type="nucleotide sequence ID" value="NZ_NNBL01000019.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A2M9JL42"/>
    <dbReference type="EnsemblBacteria" id="PJN07596">
        <property type="protein sequence ID" value="PJN07596"/>
        <property type="gene ID" value="CG723_33060"/>
    </dbReference>
    <dbReference type="GeneID" id="24312888"/>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00270">
        <property type="entry name" value="Ribosomal_S18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001648">
        <property type="entry name" value="Ribosomal_S18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018275">
        <property type="entry name" value="Ribosomal_S18_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036870">
        <property type="entry name" value="Ribosomal_S18_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13479">
        <property type="entry name" value="PTHR13479"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01084">
        <property type="entry name" value="Ribosomal_S18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00974">
        <property type="entry name" value="RIBOSOMALS18"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46911">
        <property type="entry name" value="SSF46911"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00165">
        <property type="entry name" value="S18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00057">
        <property type="entry name" value="RIBOSOMAL_S18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="4" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0699">rRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PJN07596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="78" mass="8990" checksum="C35049C34093FA04" modified="2018-04-25" version="1">MAKPPVRKPKKKVCAFCKDKVTYVDYKDTNMLRKFISDRGKIRARRVTGNCTQHQRDVATAVKNSREMALLPYTSTAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JM14</accession>
    <name>A0A2M9JM14_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">FMN reductase (NADPH)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">ssuE</name>
        <name evidence="2" type="ORF">CG723_31595</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000017">
        <property type="protein sequence ID" value="PJN07921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN07921">
        <property type="protein sequence ID" value="PJN07921"/>
        <property type="gene ID" value="CG723_31595"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008752">
        <property type="term" value="F:FMN reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046306">
        <property type="term" value="P:alkanesulfonate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005025">
        <property type="entry name" value="FMN_Rdtase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020048">
        <property type="entry name" value="NADPH-dep_FMN_reduc_SsuE"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03358">
        <property type="entry name" value="FMN_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52218">
        <property type="entry name" value="SSF52218"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03567">
        <property type="entry name" value="FMN_reduc_SsuE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FMN_red" evidence="1">
        <location>
            <begin position="5"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN07921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="184" mass="19331" checksum="787A5E0AF172AD02" modified="2018-04-25" version="1">MAFLLTLTGSASAPGASRTAHLVAHLGRQFAEDGHEVRHFDVRSLPAEALLSADAKDPEVARAVELVARADALIVASPVYKAAYSGVLKTFLDLLPQYALRDKAVLPLATGGSPAHVLAVDYALRPVLTSLGADVAQGWFVLDRHITVDADRTVTLAPEAHDALAPVVERFRAALPAGSRLAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JM65</accession>
    <name>A0A2M9JM65_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CG723_31390</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000017">
        <property type="protein sequence ID" value="PJN07948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN07948">
        <property type="protein sequence ID" value="PJN07948"/>
        <property type="gene ID" value="CG723_31390"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PJN07948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="179" mass="19850" checksum="D03C2794A97A92A6" modified="2018-04-25" version="1">MGSEETRLVVVRGNSASGKSSVAAGIRDRFGRGLALVGQDNLRRIVLRERDVPGGKNIGLIDTVARYSLDAGYHVVVEGIMYADRYGPMLEDLVGEHRGVSRCYYLDVPLVETFARHATKPDLDYLTHVTEQHLQGWYRERDLLPSGIETVIDASSTLEGTVARIVRETGLDQVQPIDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JMC3</accession>
    <name>A0A2M9JMC3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Sensor histidine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_30505</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000016">
        <property type="protein sequence ID" value="PJN08025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08025">
        <property type="protein sequence ID" value="PJN08025"/>
        <property type="gene ID" value="CG723_30505"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011712">
        <property type="entry name" value="Sig_transdc_His_kin_sub3_dim/P"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07730">
        <property type="entry name" value="HisKA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="17"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="41"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="70"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="105"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="131"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="domain" description="HisKA_3" evidence="2">
        <location>
            <begin position="181"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN08025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="388" mass="41268" checksum="7E38F5365C00C14C" modified="2018-04-25" version="1">MRWIAWNDATPSSLRRLDASVAAAAALVGFGNSWVKPSNGLLTGAPTVTVAVLSGAVGLVLWWRRKRTVMVGWLVVLCHLLLFTPTALAVALYTVGSTYPNRWRLLAWFAVLGCLSDAGALWLGGAWDFRGASYSLALVVGPLVVGYAVALRRDLATAAQTELATREREHVLVVEQARVNERSRIARDMHDVVAHRVGHIVLLAAALRVGPGVANPKVADDAEQIRHEGRRALEELRAILGVLTPDRAGRPAPRALRVDVGDLDDLVRSARRAGLHADLSMEGEPGALPTLVQQAVYRTLQESLTNAAKYAPGANVGIELRCGPDTVDLTVINGPASGPPADELPSGGNGLLGLDERASLLGGELTAGPEGEGFRVELHLPIARPDTM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-09-29" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JMQ6</accession>
    <name>A0A2M9JMQ6_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">HTH asnC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CG723_29525</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000015">
        <property type="protein sequence ID" value="PJN08148.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08148">
        <property type="protein sequence ID" value="PJN08148"/>
        <property type="gene ID" value="CG723_29525"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000485">
        <property type="entry name" value="AsnC-type_HTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019888">
        <property type="entry name" value="Tscrpt_reg_AsnC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13404">
        <property type="entry name" value="HTH_AsnC-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00344">
        <property type="entry name" value="HTH_ASNC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50956">
        <property type="entry name" value="HTH_ASNC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH asnC-type" evidence="4">
        <location>
            <begin position="196"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PJN08148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="337" mass="35948" checksum="F60C985AC03B0A01" modified="2018-04-25" version="1">MVSPVTHPVPATPTAAANAPAPLDPLDRRIVAALQIDGRASWRRIAAAIGEPERKVARRGLRLLESGDVAVRGLVVRGETVILRMTCRPGSVRDAAVAAARRADCIFSYALAGPVDCVAELQFPQGQLGPLMLDEVPALPGLVSQSVSPVLRYFRTVHEWSPGILGAGEIEALGGPSGIVDEIGLPEVEVGPEEHAILGALAEDGRRTHEDLAAVAGVSVATARRRVETLTRDGHVSIRAAVEPALLGLPVEALLWIRTRPDEVEKVGRLLVESPLVRYAAVVMGEHQLLVDVTQPSKAALYEFLTASPWVRHVEAVQSHLVVDAFKRSGVEFPTSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JN98</accession>
    <name>A0A2M9JN98_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GNAT family N-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_28565</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000014">
        <property type="protein sequence ID" value="PJN08343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08343">
        <property type="protein sequence ID" value="PJN08343"/>
        <property type="gene ID" value="CG723_28565"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017255">
        <property type="entry name" value="AcTrfase_GNAT_prd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037663">
        <property type="entry name" value="Acetyltransf_GNAT_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="2"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN08343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="169" mass="18612" checksum="23E56413DF6016D5" modified="2018-04-25" version="1">MPEMRPAHVRDHPALVRHVQNWWGDSRSPARARELSRLLPKVFLQFFAGTSLVVEDGSGIRAFLVGFHSADNETEAYIHFVGVDPELRGRGVARGLYETFFRQAAGAGRREVRAITSPGNKGSVAFHRAMGFTVVAGDRETDGVPVHSDYDGPGEDRVCFVRALSPPRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JNA3</accession>
    <name>A0A2M9JNA3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MarR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_28600</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000014">
        <property type="protein sequence ID" value="PJN08348.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08348">
        <property type="protein sequence ID" value="PJN08348"/>
        <property type="gene ID" value="CG723_28600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000835">
        <property type="entry name" value="HTH_MarR-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12802">
        <property type="entry name" value="MarR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00347">
        <property type="entry name" value="HTH_MARR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50995">
        <property type="entry name" value="HTH_MARR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH marR-type" evidence="1">
        <location>
            <begin position="1"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN08348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="161" mass="17199" checksum="F5FC9D7B00022D0A" modified="2018-04-25" version="1">MSRARQDLLSRTALGVFRLNGQFLSVSEELSRPAGLTAARWQVLGAVLAEPLPVAGIARVMGITRQSVQRVADLLVTQGLAAYEPNPAHRRAKLLAPTEEGRAAVARIGPGHAALADRLAKALGEDELAATVRMLERLSAALDEVTDHPRDHPTAHPVTEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JNN8</accession>
    <name>A0A2M9JNN8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Sodium-independent anion transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_28300</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000014">
        <property type="protein sequence ID" value="PJN08481.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08481">
        <property type="protein sequence ID" value="PJN08481"/>
        <property type="gene ID" value="CG723_28300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015116">
        <property type="term" value="F:sulfate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.750.24">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011547">
        <property type="entry name" value="SLC26A/SulP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002645">
        <property type="entry name" value="STAS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036513">
        <property type="entry name" value="STAS_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01740">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00916">
        <property type="entry name" value="Sulfate_transp"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52091">
        <property type="entry name" value="SSF52091"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50801">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="25"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="51"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="94"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="126"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="150"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="180"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="219"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="301"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="327"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="359"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="domain" description="STAS" evidence="2">
        <location>
            <begin position="400"/>
            <end position="488"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN08481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="494" mass="51982" checksum="A9E2027582A26281" modified="2018-04-25" version="1">MSPVARLRGLKPDWLSDPKVWRTEILAGLVVGLALIPEAISFSVIAGVDPAIGLFAAFTMAVTIAIVGGRRAMISAATGAVALVIAPLNREHGFGHLVAAVILAGVFQIVLGALGVAKLMRFVPRSVMVGFVNSLAILVFMAQVPEMRDVPWPVYPLIAGGLALMVFFPKVTKVIPAPLVSIVILTVITVAAGIAVPTVGDKGDLPSSLPVPGLPDVPFTLDTLTTIAPYALAMALVGLMESLMTAKLVDEITDTHSSKTRESIGQGIANIVTGFFGGMGGCAMIGQTMINVRVSGARTRLSTFLAGVFLMVLCIVFGPIVSDIPMAALVAVMVMVCFATFDWHSVAPRTLKRMPTGEIAVMVITVVCVVSTHNLAIGVVVGTITAMVVFAKRVAHFAEVTAVTDPDDATVVYRVTGELFFASSNDLVGRFDYATDPDRVVIDLSAAHIWDASSVAALDAIETKYEQRGKTVEIIGLNRPSAQIHEKLSGELTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JPS3</accession>
    <name>A0A2M9JPS3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cellulose-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_25530</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000011">
        <property type="protein sequence ID" value="PJN08860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08860">
        <property type="protein sequence ID" value="PJN08860"/>
        <property type="gene ID" value="CG723_25530"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="90"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="291"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="188"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="90"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN08860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="311" mass="34623" checksum="8A27433D772E7893" modified="2018-04-25" version="1">MSDTSPYGFELVRRGYDRAQVDERISKLVSDRDSALARITALEKRIEELHLETQNAQAQVNDAEPSYAGLGARVEKILRLAEEEAKDLREEARRAAEQHRELAESAAQQVRNDAESFAAERKSKAEDEGVRIVEKAKSEAGTLRAEAQKDAQSKREEADALFEETRAKAAQAAADFETNLAKRREQSERDLASRQAKAEKRLAEIEHRAEQLRLEAEKLRTDAERRARQTVETAQRQAEDIVADANAKADRIRSESERELAALTNRRDSINAQLTNVREMLATLTGAAVAAAGAPAEDEPISRGVPAQQTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JQ59</accession>
    <name>A0A2M9JQ59_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Sugar ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CG723_26190</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CB01635</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000011">
        <property type="protein sequence ID" value="PJN08975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08975">
        <property type="protein sequence ID" value="PJN08975"/>
        <property type="gene ID" value="CG723_26190"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="77"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="110"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="144"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="189"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="243"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="73"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PJN08975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="279" mass="31100" checksum="41AB7E6D5AE663EF" modified="2018-04-25" version="1">MKRSASATFRRAWPNVTAVILFIGFVFPVYWMFATSLKPTGDIISENPVWFPTDITFEHFRTAFGADNFWTLVRNSVTVTVLAVVFSLVIGLAASFALARMRFKGRRGFIIGFMLAQMAPWEVMVIAIYMIVRDASMLNSLVPLTLFYMVMILPFTLLTLRGFVAAVPRELEESAMVDGCTRMQAFRRVILPLLAPGLMSTSMFGFITAWNEFPMVLVLNKSPEAQTLPLWLSSFQTAFGDDWGATMAASSLFAIPILILFVFLQRRAVSGLTDGAVKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JQK6</accession>
    <name>A0A2M9JQK6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Chemical-damaging agent resistance protein C</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_24895</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000010">
        <property type="protein sequence ID" value="PJN09152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN09152">
        <property type="protein sequence ID" value="PJN09152"/>
        <property type="gene ID" value="CG723_24895"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06974">
        <property type="entry name" value="TerD_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003325">
        <property type="entry name" value="TerD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02342">
        <property type="entry name" value="TerD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TerD" evidence="1">
        <location>
            <begin position="1"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN09152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="191" mass="20266" checksum="4E2E10B3393575F5" modified="2018-04-25" version="1">MAVSLSKGGNVSLTKEAPGLTAVTVGLGWDVRTTTGTDFDLDASAIAVNPQGKVYSDGHFVFFNNKATPDQTIVHTGDNVTGQGEGDDEQINVNLAGLPADIDKIVFPVSIYDAENRSQNFGQVRNAFIRIVNQAGGTEIARYDLSEDAATETAMVFGELYRNGAEWKFRAVGQGYASGLVGIAQDFGVNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JQL5</accession>
    <name>A0A2M9JQL5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">GntR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_24500</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000010">
        <property type="protein sequence ID" value="PJN09087.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN09087">
        <property type="protein sequence ID" value="PJN09087"/>
        <property type="gene ID" value="CG723_24500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07377">
        <property type="entry name" value="WHTH_GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
        <property type="entry name" value="GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00035">
        <property type="entry name" value="HTHGNTR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00345">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50949">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH gntR-type" evidence="2">
        <location>
            <begin position="15"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="68"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN09087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="294" mass="32730" checksum="266E52B3C9DF1510" modified="2018-04-25" version="1">MVVTQESVAVNGSRRSSPQEIADVLRERIKAGELRAGERLPTQAELAEEFGVERGAVRQALRSLQEDGLLSNVSKGSPPRIAEQAPARDEPQRTMVGLAPRLSEAFASPQVRIDAVCLTAETLMLALGEPLRFIHEGRIRPDSVDVRILLPGRDINLAFPVSVEDAGGGEGDVVHQRWLDQRNAQGQVLRHNLRSLRSSHGIDVRVTFRALPFTPPVKLYLLNGNEALLSYYLVTRREEEIESGTLDMYDTLGTESLLFSFEKRAGQRDTAFVEESQKWFDALWETITTDLTLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JQW8</accession>
    <name>A0A2M9JQW8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CG723_23275</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000009">
        <property type="protein sequence ID" value="PJN09276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN09276">
        <property type="protein sequence ID" value="PJN09276"/>
        <property type="gene ID" value="CG723_23275"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="SSF54427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PJN09276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="130" mass="14239" checksum="4A2A419543831D62" modified="2018-04-25" version="1">MSDTTTSTDTASAPFLTAWFEILDTDEPNRILDLISDDFTLSILFSTGDGNATDFAGDRAALVGYLEQRERGTRTHHRLSATTLGQDELFLGEVRRAGVPEATFVAAGRVDDGGRLQRLLIGRSSEIRFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JR52</accession>
    <name>A0A2M9JR52_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CG723_23220</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000009">
        <property type="protein sequence ID" value="PJN09267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN09267">
        <property type="protein sequence ID" value="PJN09267"/>
        <property type="gene ID" value="CG723_23220"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PJN09267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="305" mass="32999" checksum="64FC423B718B4FF6" modified="2018-04-25" version="1">MSAVGEAHRAVSRIAKADDGQGKLLRGLGDHLPQPRDFDDWHWLTQLNQARAVAFGIRHFRSHAPYCMGTVVWQLNDCWPVVSWSAVDVDGRRKPLWYALREAYADRILVVRDGAVYAVNDGPQIWAGPAEPDAAVTVTAPGSDSVPLRVARRSLSGATLGEAEMSVDCAPRSVARIELPVELTGPDDKTRELLVAELGGQRVVEFYAEDTEVAFPCADLTAHVDPLGPGEADGYRVTVDAHTLVRDLALFPDRLDPAAVADRALVTLLPGEQGAFEVTGARLDDPSALKSRPVLRCVNEATAPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JR72</accession>
    <name>A0A2M9JR72_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_23690</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000009">
        <property type="protein sequence ID" value="PJN09342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN09342">
        <property type="protein sequence ID" value="PJN09342"/>
        <property type="gene ID" value="CG723_23690"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001845">
        <property type="entry name" value="HTH_ArsR_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01022">
        <property type="entry name" value="HTH_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00778">
        <property type="entry name" value="HTHARSR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00418">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50987">
        <property type="entry name" value="HTH_ARSR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH arsR-type" evidence="1">
        <location>
            <begin position="1"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN09342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="101" mass="11047" checksum="E9321030AFBAB8E0" modified="2018-04-25" version="1">MLTSVDTDVIRVLGDPLRLKIVTLLAQETLCTTHLVEETGAKQTNLSNHLKVLREAGLVETEPCGRFTYYKLCPEVLAGLSEQFAELAASARTAAENKRAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JRD8</accession>
    <name>A0A2M9JRD8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MarR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_23165</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000009">
        <property type="protein sequence ID" value="PJN09418.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN09418">
        <property type="protein sequence ID" value="PJN09418"/>
        <property type="gene ID" value="CG723_23165"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000835">
        <property type="entry name" value="HTH_MarR-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01047">
        <property type="entry name" value="MarR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00598">
        <property type="entry name" value="HTHMARR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00347">
        <property type="entry name" value="HTH_MARR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50995">
        <property type="entry name" value="HTH_MARR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH marR-type" evidence="1">
        <location>
            <begin position="19"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN09418.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="165" mass="18340" checksum="792E227C801D1165" modified="2018-04-25" version="1">MPDETTAAETTPRPPAELTAAPGYQVRRLYQAYLAVWLREVDPVLTGPQFAVLQTIQAHPGRDQRSLASAVALDTSTMADVAKRLDNRGLIMRQTAADDGRRKLLYLTEDGRHVLREAEHRARALDKLLLEPFSETERTTYLHMLTSLADHWVGLAGGPTPTPSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JS49</accession>
    <name>A0A2M9JS49_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Polyisoprenoid-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_20910</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000007">
        <property type="protein sequence ID" value="PJN09673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN09673">
        <property type="protein sequence ID" value="PJN09673"/>
        <property type="gene ID" value="CG723_20910"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.128.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007372">
        <property type="entry name" value="Lipid/polyisoprenoid-bd_YceI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036761">
        <property type="entry name" value="TTHA0802/YceI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04264">
        <property type="entry name" value="YceI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00867">
        <property type="entry name" value="YceI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101874">
        <property type="entry name" value="SSF101874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YceI" evidence="2">
        <location>
            <begin position="29"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN09673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="202" mass="21235" checksum="5F9B1739E2B80D81" modified="2018-04-25" version="1">MGLFGRKNDDATPAATGTAGPDLAALTGDYAIDPAHTTIGFVARHAMVTNVKGSFTQSSGTLHLDGADPAKSTASIDVTMSSIDTGSADRDTHLKSSDFFKTDEFPTMTFRSTSAESLGGDDYRMTGDLTILGTTKPITIDLEFNGSATDPFGNERVGFEGKGQILRSEWGLTWNAALETGGVLVSDKIKLTFDISAIKNAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JSD3</accession>
    <name>A0A2M9JSD3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_21530</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000007">
        <property type="protein sequence ID" value="PJN09780.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN09780">
        <property type="protein sequence ID" value="PJN09780"/>
        <property type="gene ID" value="CG723_21530"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="115"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="159"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN09780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="734" mass="77319" checksum="DA9B596A661D4B13" modified="2018-04-25" version="1">MDTDGTQGAGGTHDARGTHATPVPRPAGPPNPPAVSADRGARSGSPARAGTPPPRPTHAPGAAGASAGAAGAAFLGWLRAPRPAAEPGIWRFAHRPRPAQEPEVVPARQLLSGAVIAFLVGWLVWSLLWNGYLGGWWLLPLYAMVPDSWAQPHSVGSVVVVYLYYAVFAVGIMIAVGRLGRWGEVWRRFGLPAWRKAVPVAQERPPAPEEDPARWPQLRAAGAADAADRLAADARAGLMCDVDQARIARAWQGVRRGSHPLASFSAAVVKDGAGACLHPSGARDLPARAARHDLATAQVRIGTTADDVRNPYAYRGTGLAFGPDLLGTSLVAVGPAGAGKTGSVVWPIAESLCLGALAGRAVVVVVGPAGAGLGAADGYDVVIRIGHPESVHDLDLYGGTSDPDEAAAVLAEALVGDLADPHPGGDSRRSTTVIAQLIGPYHAVHGRFPSVPELRRLLDGAPEPLAALRQALTDSGHEAMLRELDARERQLGHPGDVGAVLADRVALLDRPAFASFFDTTGRGRPFSLRALDRPVRVRIDLPERGHADASRILARLVLAQFVAGASVRDDRSLFACLILDDATGAVTPQAVRGIQRLRSANAGAVLTLRTLDDVPRPLRGPLLGAVGCRMALSGLTPWDGQDFAEVWGKEWTETRDVTDRQIIAETPLGKTVHMLRRVITGNAPTARAVTVRQVERERWSASELAHAVPPGHAVLSLTTVRGEHAPPLLVDLRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JSK4</accession>
    <name>A0A2M9JSK4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_21455</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000007">
        <property type="protein sequence ID" value="PJN09767.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN09767">
        <property type="protein sequence ID" value="PJN09767"/>
        <property type="gene ID" value="CG723_21455"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014857722" evidence="1">
        <location>
            <begin position="28"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN09767.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="150" mass="16582" checksum="BB472F2B11E99623" modified="2018-04-25" version="1">MRSKTLKTTLTLCAAASLAAAMVPASASTAAPKPQQKHADTVLVDCTWKPQVRPTDFMLACGDGNSLLTSLKWSHWGPSTAVATGTSLVNDCKPYCAAGKFRSYRVTVRLDRPQSWTKHQDRRHYSRITLTYPQGHPDAFHRVVTTPLWN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JSZ1</accession>
    <name>A0A2M9JSZ1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_19895</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000006">
        <property type="protein sequence ID" value="PJN09989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN09989">
        <property type="protein sequence ID" value="PJN09989"/>
        <property type="gene ID" value="CG723_19895"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="38"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN09989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="74" mass="7787" checksum="2B6AB18502549D28" modified="2018-04-25" version="1">MPRHDFQPGKLIAGLFLTAAGALYLGAALGGWEVEWFAVIPLVTVGLVLAGAAGTATYAIRRRQRPHPTDSSSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-06-02" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JTE2</accession>
    <name>A0A2M9JTE2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">RNA polymerase subunit sigma</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CG723_20000</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CB01635</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000006">
        <property type="protein sequence ID" value="PJN10150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN10150">
        <property type="protein sequence ID" value="PJN10150"/>
        <property type="gene ID" value="CG723_20000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039425">
        <property type="entry name" value="RNA_pol_sigma-70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000943">
        <property type="entry name" value="RNA_pol_sigma70"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007630">
        <property type="entry name" value="RNA_pol_sigma70_r4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43133">
        <property type="entry name" value="PTHR43133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04545">
        <property type="entry name" value="Sigma70_r4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00046">
        <property type="entry name" value="SIGMA70FCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0731">Sigma factor</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="7">
        <location>
            <begin position="60"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4" evidence="8">
        <location>
            <begin position="171"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="133"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="20"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PJN10150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="224" mass="24220" checksum="7BB6F042818AC7BB" modified="2018-04-25" version="1">MSSGAPAHNASVHNYGRGATDRTPPRHHGPMRDDEAAGPGAIGALVHSAVEGDEQATHDLLAHVHPLAIRYCRSRLTRLPGDARHFVEDLAQEVCVAVLLALPRYKDTGRPFEAFVFAIAAHKVADLQRAAMRHPGSTAVPSDEMPERPDDSLGPEERALLSSDAEWAKKLLANLPENQRELLLLRIAVGLTAEETGQMLGMSPGAVRVAQHRALSRLRALAEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JU46</accession>
    <name>A0A2M9JU46_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Epimerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_18805</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000005">
        <property type="protein sequence ID" value="PJN10411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN10411">
        <property type="protein sequence ID" value="PJN10411"/>
        <property type="gene ID" value="CG723_18805"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Epimerase" evidence="1">
        <location>
            <begin position="13"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN10411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="316" mass="33546" checksum="342660AFD0D0AFA5" modified="2018-04-25" version="1">MTATAHGSHTVLGSGPAGTALAQELAGRGHAVRLVDRKGDGPAVDGVERFAADVSTLEGARVAVTGADVVHHCVNVGYHLQVEVMPRITEAILGAVQETGARLVVLDTLYPYGETKGEVMTESTPWNATSRKGRMRAELDGEYLAAHQEGRVRVALARSADFVGPGVINSSLGATVFPGALTSGEVLGLGDIDLPHSYTYIGDVASGLATLGERPDGDGRVWHLPTAPAVSTREIHRLIEARVGRPLSATILDEARPFGPFDEVFMAEYAEMFYQHTEPQIVDSAAFEAAFGVRPTPLGEALDHTLAWYGEWLAAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JU79</accession>
    <name>A0A2M9JU79_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Protein phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_18335</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000005">
        <property type="protein sequence ID" value="PJN10337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN10337">
        <property type="protein sequence ID" value="PJN10337"/>
        <property type="gene ID" value="CG723_18335"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07228">
        <property type="entry name" value="SpoIIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00331">
        <property type="entry name" value="PP2C_SIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="SSF81606"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="59"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="84"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="domain" description="PPM-type phosphatase" evidence="2">
        <location>
            <begin position="136"/>
            <end position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN10337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="401" mass="42449" checksum="DE8F6C797865F30A" modified="2018-04-25" version="1">MDRLLERPSGQGLVVVPLVLIVVITLVDVHSPTDVHLGPLLVIAPALTASIAGPRLTALVGLLAVGAQILIGALHGGLGTANHISQIIAITLLSALIVIFCRAGERRRHELNRVRSVSEAAQRVLLRPPPRRVGPLRVAWLYLAAGDEAKIGGDLFAVARAAHPSTRALIGDVRGKGLASIGEASVVLGAFREGAHRYALLPDLVAAMDDSVARNLEEVADTEHDAGEHFVTALVLDIPDDGPHAEMVTCGHPPPLLVREHQVTELAPRQSAPPLGMGELSVLPLRSDRFAFTAGDFLVLYTDGVIEARSPTGAFYPLAERVASFPSLPAGGPDSLLNHIHRDLLAHTGGQLNDDIALLVIERVPTRHLLRPLLNGRPMADHAADAYPDGAPPSRAHGRGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-09-29" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JUM9</accession>
    <name>A0A2M9JUM9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_15365</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000004">
        <property type="protein sequence ID" value="PJN10595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN10595">
        <property type="protein sequence ID" value="PJN10595"/>
        <property type="gene ID" value="CG723_15365"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003477">
        <property type="entry name" value="PemK-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011067">
        <property type="entry name" value="Plasmid_toxin/cell-grow_inhib"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02452">
        <property type="entry name" value="PemK_toxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="28"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN10595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="150" mass="16799" checksum="705672931FECF957" modified="2018-04-25" version="1">MDTSWWLALAAVLLLALVATLVDGWGRGHRRRPGGRTRPPRGPRARGTRPQPGEIWWAQVPYEDGPGGKDRPCLVLAVHRRRVRVAKITSKYHDERAGVIALPPGSVGDAQGRPSFLETDELREVPEGDFRRRAGVLDPVVWDQVRYLAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JUP3</accession>
    <name>A0A2M9JUP3_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA helicase</fullName>
            <ecNumber evidence="2">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CG723_15060</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CB01635</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O = ADP + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="2"/>
    <dbReference type="EMBL" id="NNBL01000004">
        <property type="protein sequence ID" value="PJN10542.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN10542">
        <property type="protein sequence ID" value="PJN10542"/>
        <property type="gene ID" value="CG723_15060"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000212">
        <property type="entry name" value="DNA_helicase_UvrD/REP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014016">
        <property type="entry name" value="UvrD-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027785">
        <property type="entry name" value="UvrD-like_helicase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11070">
        <property type="entry name" value="PTHR11070"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00580">
        <property type="entry name" value="UvrD-helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13538">
        <property type="entry name" value="UvrD_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51198">
        <property type="entry name" value="UVRD_HELICASE_ATP_BIND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 8" id="KW-0347">Helicase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UvrD-like helicase ATP-binding" evidence="7">
        <location>
            <begin position="241"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="360"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="618"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="262"/>
            <end position="269"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PJN10542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="805" mass="87739" checksum="0E3AAA5DD3B19358" modified="2018-04-25" version="1">MPSTSEGGPVAAQAHQQTALDQDRDSVREREIGVEQEHLDQVYRRLEEKIHEAEFLMNDAAKRGQVGTPGALAERDAQVFRAGIHLNRLNNEFEDFLFGRIDLLLGKDGKKGPDGAYTAVEPAEGAVREDADGQRTAGIAETLHIGRIGVLDADYSPLVIDWRAPAAAPFYRSTPVDPGRVVRRRVIRSKGRKVLGVEDDLMRPELTAYLDGEQLPVIGDGALMAALGQARSHTMRDIVASIQAEQDLVIRAPAASVTYVEGGPGTGKTAVALHRAAYLLYQDRRRYAGGILIVSPTPLLVAYTEGVLPSLGEEGQVAIRAVGSLVDGAEATVYDSPAVARVKGSSRMLRVLRKAARGALEAGTPAKEPSQGTGQLAFGEEPDDDAAAPAEQPTRLRVVAFGRRLELEAADLARIRQNALSGTAPVNMLRPRARKLLLDALWSQSGAGTRHSDPELAAELRSSFDDDITSEDDFVRFLDAWWPELTPRGVLAAMGDERRLGRWARRILNPGEVRKVARSLRRDALSVHDVALLDELNAVLGTPLRPKKKREYDPLDQLTGLEELMPERHETQRERAERLAQERTEYAHVIVDEAQDLTPMQWRMVGRRGRHATWTVVGDPAQSSWSDPDEAAEARDEALGSRPRRRFTLTVNYRNPAEIAELAAKVLALAMPGSESPSAVRSTGVRPRFAVVRDGLGHSVREEAARLLDQVDGTVGVVVAMNRRDEAARWLAGLGDRVVALGSLEAKGLEYDATIVVSPAEIADESPAGLRVLYVALTRATQQLTVVSGSRDEPDADGVPDLLRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JUP4</accession>
    <name>A0A2M9JUP4_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">RDD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CG723_15300</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CB01635</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000004">
        <property type="protein sequence ID" value="PJN10583.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN10583">
        <property type="protein sequence ID" value="PJN10583"/>
        <property type="gene ID" value="CG723_15300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010432">
        <property type="entry name" value="RDD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06271">
        <property type="entry name" value="RDD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="92"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="184"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="domain" description="RDD" evidence="7">
        <location>
            <begin position="86"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="42"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF06271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PJN10583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="229" mass="23727" checksum="8C44C020B5B4D8F7" modified="2018-04-25" version="1">MSTEPPPPGSGQPPEDDPFRKPPPSQSGGGSPYDGPGNGPGNPYDSAPPPPGGTPPPPYGGGGGEGGPYGGDPYGSDPLAGMPPLADSGKRVLARIIDIILVSIVVGLLSWAFGIAEYQTNPDKIVYGKQFGQSVLAAVLYIGYDTFMTARTGQTLGKRLLKLRVANLNDGATPSVQTNLVRAAVLWLPAVFCCACIWTAICGGWSFFDKPYKQGLHDKAAKTVVVSTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JUR4</accession>
    <name>A0A2M9JUR4_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Protease HtpX homolog</fullName>
            <ecNumber evidence="12">3.4.24.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">htpX</name>
        <name evidence="14" type="ORF">CG723_18980</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">CB01635</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="12">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="12">Cell membrane</location>
            <topology evidence="12">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the peptidase M48B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.-" evidence="12"/>
    <dbReference type="EMBL" id="NNBL01000005">
        <property type="protein sequence ID" value="PJN10517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN10517">
        <property type="protein sequence ID" value="PJN10517"/>
        <property type="gene ID" value="CG723_18980"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00188">
        <property type="entry name" value="Pept_M48_protease_HtpX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022919">
        <property type="entry name" value="Pept_M48_protease_HtpX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001915">
        <property type="entry name" value="Peptidase_M48"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01435">
        <property type="entry name" value="Peptidase_M48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 12" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 12 14" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="4 12 14" id="KW-0645">Protease</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="8 12" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="6"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="136"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="172"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M48" evidence="13">
        <location>
            <begin position="61"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="active site" evidence="12">
        <location>
            <position position="127"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="126"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="130"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="202"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF01435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="PJN10517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="287" mass="30884" checksum="6E54E06CF9340B11" modified="2018-04-25" version="1">MLVTVFLLGLLYVAFIGALLVLLKSTLLVVVLAAGLLASQYWFSDRIALYAMHGRIVTREEQPQLHGVVDRLCATADMPKPQVAIAGTDLPNAFATGRNADHAVLCVTTGLLRRLEPDELEGVLAHELSHVAHRDVAVITVASFLGVIAGIVVRFAFYSELLGGRRRTDQNTLVVLAVVVGVSAAVYAISFVLIRALSRYRELAADRAAALLTGRPSALASALTKLDGDIARIPNKDLRTARAFNAFYFIPALSKTAPLPRLFSTHPSLEQRLDQLAAISADLGRPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JUX1</accession>
    <name>A0A2M9JUX1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DNA-binding response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CG723_15790</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000004">
        <property type="protein sequence ID" value="PJN10669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN10669">
        <property type="protein sequence ID" value="PJN10669"/>
        <property type="gene ID" value="CG723_15790"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="6"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="domain" description="HTH luxR-type" evidence="3">
        <location>
            <begin position="147"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PJN10669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="219" mass="23515" checksum="16A75AF931BB3EEC" modified="2018-04-25" version="1">MSSALRVVLAEDAVLLREGLVGLLARFGHEVVAAVGDADALRAAVAEHTPDLVLTDVRMPPGFQDEGLRAALALRADRPGLPVLVLSQYVQRSYAAELLDTGDGTGVGYLLKDRVGQVEQFVEAVERVASGGTVVDPEVVRQLLRRRRDPLDRLTPREREVLALVAEGRSNGAIARDLVVSEAAVGKHIGNILGKLDLPPADDTDTHRRVLAVLAYLRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JUZ4</accession>
    <name>A0A2M9JUZ4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Glycosyl transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CG723_15725</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CB01635</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Lipid metabolism.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000004">
        <property type="protein sequence ID" value="PJN10658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN10658">
        <property type="protein sequence ID" value="PJN10658"/>
        <property type="gene ID" value="CG723_15725"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00241">
        <property type="reaction ID" value="UER00356"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025993">
        <property type="entry name" value="Ceramide_glucosylTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13506">
        <property type="entry name" value="Glyco_transf_21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="76"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="109"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="426"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="459"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="543"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="568"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="595"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="601"/>
            <end position="615"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PJN10658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="641" mass="71993" checksum="7776C468018861EA" modified="2018-04-25" version="1">MTSTPTGARQNFDPSQTTQLRVPPHRTGGFRRIKKALPRYDYEHYSRLAGPLTQPEPGKPYKVQYRSLLSQEPHRLRAALMLGAAPLLSLVLLFWLLQPEHWTQRDYPAYDFLPALDVVMLVSIGLIEFFRCMNVLSNAHATLVARDPIPVVPETGTRVAFLTSFVPGKEPIEMVTKTLEAAVKLRHRGLLHIWLLDEGDDPEVKAVCERLGVHHFSRKGVARWNQAKGPHRAKTKHGNYNAWLDAHGDDYDYFASVDTDHVPLPNYLERMLGFFRDPDVGFVIGPQVYGNYDNFVTKAAESQQFLFHALIQRAGNAYGAPMFVGTSNAVRIKTLKQIGGLYDSITEDMATGFEIHRAKNPATGRKWRSVYTPDVLAVGEGPSAWTDFFTQQMRWSRGTYETILKQYWKGFFSLPPSKLFNYTMMIIFYPMSAMNWILAALSCALFLGLGASGVNIDPTIWLMLYGNASALQIGLYIWNRRHNVSPHEPEGSGGVAGMVMSALSAPLYAKALFDAVLRRKSKFVVTPKGDSASPDRWFGTFRYHWYFILVFAGSIAAGFVYGHSHPAMITWACFALLITALPMFAWRYMLRQDRKKPKPPAAETSGPPHPQPHSVPQQKPAWAADGGNDQTMQISLGGRNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JV68</accession>
    <name>A0A2M9JV68_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_15780</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000004">
        <property type="protein sequence ID" value="PJN10667.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN10667">
        <property type="protein sequence ID" value="PJN10667"/>
        <property type="gene ID" value="CG723_15780"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002577">
        <property type="entry name" value="HTH_HxlR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01638">
        <property type="entry name" value="HxlR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51118">
        <property type="entry name" value="HTH_HXLR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH hxlR-type" evidence="2">
        <location>
            <begin position="16"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="119"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN10667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="143" mass="15647" checksum="8FE5BA0563BD375C" modified="2018-04-25" version="1">MSGSAWRKGGGPEQACPISPVLDIVFSRWTTPILWALNEYGTQRFVQLQRAIGTITPKVLTQRLRQMERDGLVVRTYYPEVPPRVEYEISDLGRSLAPLFATLAEWSSGHLPLVEEARERFDAGEGAGTAPVTGPSPAAGPAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JV90</accession>
    <name>A0A2M9JV90_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">RNA polymerase subunit sigma-70</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CG723_16620</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CB01635</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000004">
        <property type="protein sequence ID" value="PJN10801.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN10801">
        <property type="protein sequence ID" value="PJN10801"/>
        <property type="gene ID" value="CG723_16620"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039425">
        <property type="entry name" value="RNA_pol_sigma-70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007630">
        <property type="entry name" value="RNA_pol_sigma70_r4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43133">
        <property type="entry name" value="PTHR43133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04545">
        <property type="entry name" value="Sigma70_r4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0731">Sigma factor</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="6">
        <location>
            <begin position="25"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4" evidence="7">
        <location>
            <begin position="117"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PJN10801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="173" mass="19378" checksum="6537A168B39DD886" modified="2018-04-25" version="1">MLRRRTRRAEAADPLDAAQEDRVRAVLSLGGVPHGDLQDGVQQVRLRLLERAARGDEAPRDVSAWAAVVASNLAMDWHRARRRQERLGERLASLRQEQRAEDGAESRVLSLAVAQGLDELPDTQRQVVVLRFYADLPVRAIAEELGIPEGTVKSRLHTAVRMLRARLREGEVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JWC1</accession>
    <name>A0A2M9JWC1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Aminotransferase class I and II</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_09205</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN11128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN11128">
        <property type="protein sequence ID" value="PJN11128"/>
        <property type="gene ID" value="CG723_09205"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044249">
        <property type="term" value="P:cellular biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotran_1_2" evidence="1">
        <location>
            <begin position="48"/>
            <end position="390"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN11128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="403" mass="43468" checksum="2BE8D4078BFD16E6" modified="2018-04-25" version="1">MHAFMNIKKTIGISNDFWNVTADSGMAGIVAENVGAGRYAARADSHEFLNMSSYSYLGLDSHPALIRAAADAVTQNASLNTSVSRMRVHFGILKDAEDALSDLFRVEAVTLASCAAAAWSALPLVASGAFTDGVPPLMVFDKHAHFCLNAMKPSVADEAEVRTIAHNDLDALEELCRTHPNVAYVADGVYSTGGQAPVRELLALQEKYGLFLFFDEAHGVSTCGDQGRGVVLDAMGEINDRTLIITSLNKGFGASGGAIFLGPQGSRHRRDLALRYGGPLTWSQRINTAGLGAIVASATLHRSPELKELQHRLQENIDCFDALVPTANRGDGLPIRFIDIGSEEKTVRIGRALLSAGYYTSALFFPVIARGKAGLRIMLRADMTRTDIENFGRLVNELRSQND</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JWT4</accession>
    <name>A0A2M9JWT4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Proline racemase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_09690</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the proline racemase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN11207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN11207">
        <property type="protein sequence ID" value="PJN11207"/>
        <property type="gene ID" value="CG723_09690"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008794">
        <property type="entry name" value="Pro_racemase_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33442">
        <property type="entry name" value="PTHR33442"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05544">
        <property type="entry name" value="Pro_racemase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF029792">
        <property type="entry name" value="Pro_racemase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00028">
        <property type="entry name" value="Proline_Racemase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN11207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="333" mass="36010" checksum="D4F19EEB16B2ED12" modified="2018-04-25" version="1">MRSKLVLHAVDSHTEGMPTRVITGGIGTVPGATMNERRLYFREHRDDIKQLLMNEPRGHAAMSGAILQPPTRPDCDYGVIYIEVSGYLPMCGHGTIGVATVLVETGMVEVVEPITTIRLDTPAGLVVAEVAVENGAAKSVTLRNVPSFSVGLDRAITLADGRTVTYDLAYGGNFYAILPLDRFGLPFERERKDDILAAGLALMDAINAKDEPVHPEDPSIRGCHHVHLYAPGATARYSRHAMAIHPGWFDRSPCGTGTSARMAQLYARGELPLHTEFVNESFIGTQFTGRLLDTTDVAGTPAVLPSFTGRAWVTGTAQYLLDPDDPFPAGFVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JX13</accession>
    <name>A0A2M9JX13_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CG723_10980</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN11430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN11430">
        <property type="protein sequence ID" value="PJN11430"/>
        <property type="gene ID" value="CG723_10980"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PJN11430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="258" mass="27477" checksum="43310C825BA03B82" modified="2018-04-25" version="1">MDITDFSRDFFSLDGKNAIVTGGNTGLGQAFSLALAKAGANVLVPALADDGGETRKLIEAEGRRMEFLEADITGAGVPRQVVEHCVDTLGSVDILVNSAGICNLASVEEFDRAAWDPMLAVNLTAPFELAHEATKFMIPQRSGKIINIASLFSFLGGQMSPAYAATKHGIAGFTKAYCDELAQHNIQVNAIAPGYFATKITETTRANQETNQRVLDHIPAGRWGDVADLMGATVFLASRAADYVNGHVLTVDGGYLVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JX82</accession>
    <name>A0A2M9JX82_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Amino acid permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CG723_11365</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CB01635</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN11495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN11495">
        <property type="protein sequence ID" value="PJN11495"/>
        <property type="gene ID" value="CG723_11365"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004841">
        <property type="entry name" value="AA-permease/SLC12A_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00324">
        <property type="entry name" value="AA_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="22"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="53"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="94"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="137"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="163"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="203"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="244"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="286"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="344"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="371"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="410"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="446"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="domain" description="AA_permease" evidence="7">
        <location>
            <begin position="22"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="476"/>
            <end position="508"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PJN11495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="508" mass="52551" checksum="78B9B5DE4341126D" modified="2018-04-25" version="1">MSGVDVQNGTGLRRGAIGLREVLFQSITAMAPAAAVAASIPAGTAFAGGSLPLSVLIALVACLFTASCVAELARELPAAGSVSTYAARGLHPSVGFLVGWGYVFVEALVPPLLLLQLGFTTAGTLHNEWSSYPADLWWPWSLAGAAIIAVAGYFGVRASARFGTVLGAFEVVVFLAFAILLISKAGGDNTLSVFGTSHSAPGYEGWSGVFAGSVYTVLAFAGFEAAAPLAEETRDPRRTMHRAVLGAALAIGLFYVLTTYAMSVYFGPGRFATFGAEGAASWEGVARASFGLFWVLVFLAVVNSTIANANACANVSTRTAFALGRIGVFPSGFARLHPVRRSPVTGVAVQFVVAVAAMLGLGFAYDPVTAFLLLATVIVTVIIGVYIVANLACAGYFLRRGRSALRPVRHLVLPLLGIVAFVPALLTAAGLPVFDFVSELTAPVSYAGPVVAAWMLAGVVVLAVLLRRHPERIAETGRVHLDDDAPDGAPAPGPDPDAPTSQSGAAQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JX87</accession>
    <name>A0A2M9JX87_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CG723_11035</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CB01635</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN11438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN11438">
        <property type="protein sequence ID" value="PJN11438"/>
        <property type="gene ID" value="CG723_11035"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="67"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="98"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="124"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="166"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="219"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="60"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="253"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PJN11438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="285" mass="30181" checksum="56214184BB43A3AE" modified="2018-04-25" version="1">MSAGRWLIRAASLAVALGLWQLLTSLDVELWLRFGQFPTVGEVASAFGDRLGTAPYWQDVGHSLRRIVIGFLLAAALGVAAGTAIARSRWAADLLGPLVEVARPIPAIALVPVAILLLPSNEQGIVFITFTAAFFPVLVSTRHAVRALTPVWEEAVLTMGGGRLRVLFSVVLPGALPGIFGGLSVGIGVAWICVISAEMISGEYGVGYRTWQDYTVVDYPGVFVGMATIGALGWLTSTAVEFLGRRATAWLPRPPERAPSRAVRHTAAPPAVPSPAPALEKEPVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JXE1</accession>
    <name>A0A2M9JXE1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CG723_11350</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN11492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN11492">
        <property type="protein sequence ID" value="PJN11492"/>
        <property type="gene ID" value="CG723_11350"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01590">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="OmpR/PhoB-type" evidence="3">
        <location>
            <begin position="245"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PJN11492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="432" mass="46451" checksum="C694DC97B5478C28" modified="2018-04-25" version="1">MTDPWVALEPGTDPSERVRVLRRAHETFTAAGTVSRPVRSVVADSWRRSAGAHVSPDASASVELSDGDLGAYRAEHPLARVMPLFRELMGTFAQDGEHLLAVCDAHGRLLWVEGDRTTRQRAGKMNFVPGARWSETAMGTNAPGTAVAVDRPVQVFAAEHFIRRVQPWTCAAAPVHDPRSGRLLGAVDITGGDGLAHPHSLAFVQAVARAAESQLALLAPPPSDADSLRLTALGRDEALLITSGGRKIRLSRRHSEILVLLARHPEGLTGDELLCALYEDESVTPVTLRAELARLRRVLGPDILGSRPYRLAAPVESDFGTVERRLGTGAVTAAAAAFGGPLLPGSQAPAVVRIRRRLTDEIRAALIARGDPDLLADWAHAPWGEEDLDVWRALATVRPAPPVLARLRELDAEQAAPGPPTSFATYLQRPRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JXK7</accession>
    <name>A0A2M9JXK7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_12050</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN11613.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN11613">
        <property type="protein sequence ID" value="PJN11613"/>
        <property type="gene ID" value="CG723_12050"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001845">
        <property type="entry name" value="HTH_ArsR_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00778">
        <property type="entry name" value="HTHARSR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00418">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50987">
        <property type="entry name" value="HTH_ARSR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH arsR-type" evidence="1">
        <location>
            <begin position="14"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN11613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="114" mass="12291" checksum="99AE031224CDCCDA" modified="2018-04-25" version="1">MHLSPAHGVHPQNPSDEQLAYAADLLGLLADRTRLVLLHTLGSGEADVTTLTETCGAARPAVSQHLAKLRLAGLVTVRKEGRRMVYALTDGHLRRLVSEALNLADPHLGRHPLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JXM6</accession>
    <name>A0A2M9JXM6_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">DNA ligase</fullName>
            <ecNumber evidence="9">6.5.1.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Polydeoxyribonucleotide synthase [NAD(+)]</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">ligA</name>
        <name evidence="12" type="ORF">CG723_11910</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">CB01635</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="9">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the NAD-dependent DNA ligase family. LigA subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.5.1.2" evidence="9"/>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN11588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN11588">
        <property type="protein sequence ID" value="PJN11588"/>
        <property type="gene ID" value="CG723_11910"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003911">
        <property type="term" value="F:DNA ligase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00114">
        <property type="entry name" value="LIGANc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01588">
        <property type="entry name" value="DNA_ligase_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001357">
        <property type="entry name" value="BRCT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036420">
        <property type="entry name" value="BRCT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041663">
        <property type="entry name" value="DisA/LigA_HHH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018239">
        <property type="entry name" value="DNA_ligase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001679">
        <property type="entry name" value="DNAligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013839">
        <property type="entry name" value="DNAligase_adenylation"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013840">
        <property type="entry name" value="DNAligase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004150">
        <property type="entry name" value="NAD_DNA_ligase_OB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010994">
        <property type="entry name" value="RuvA_2-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00533">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01653">
        <property type="entry name" value="DNA_ligase_aden"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03120">
        <property type="entry name" value="DNA_ligase_OB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12826">
        <property type="entry name" value="HHH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001604">
        <property type="entry name" value="LigA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00292">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00532">
        <property type="entry name" value="LIGANc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47781">
        <property type="entry name" value="SSF47781"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52113">
        <property type="entry name" value="SSF52113"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00575">
        <property type="entry name" value="dnlj"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50172">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01055">
        <property type="entry name" value="DNA_LIGASE_N1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0227">DNA damage</keyword>
    <keyword evidence="8 9" id="KW-0234">DNA repair</keyword>
    <keyword evidence="2 9" id="KW-0235">DNA replication</keyword>
    <keyword evidence="1 9 12" id="KW-0436">Ligase</keyword>
    <keyword evidence="6 9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9" id="KW-0464">Manganese</keyword>
    <keyword evidence="3 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 9" id="KW-0520">NAD</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="BRCT" evidence="11">
        <location>
            <begin position="612"/>
            <end position="697"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="588"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="597"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="active site" description="N6-AMP-lysine intermediate" evidence="9">
        <location>
            <position position="120"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="40"/>
            <end position="44"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="87"/>
            <end position="88"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="141"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="175"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="301"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="325"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="419"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="422"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="441"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PJN11588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="697" mass="73723" checksum="59001FC66E9B4722" modified="2018-04-25" version="1">MTTTSGEFVLADAAAYAQAVTDASLAAGAYYTGGTSALDDDAYDRLVRAVAAYEADHPDEVLPQSPTGKVAGGAVEGDVPHTVPMLSLDNVFDGEQFTTWTASVARRIGHEVTRWNVQPKLDGLAIAARYHEGRLTRLITRGDGTAGEDVSHAIGTIEGLPDRLTEPHTVEVRGEVLMTISQFEHANEVRTEHGGAPFANPRNAAAGTLRAKERAYTVPMTFFAYGLLPLPDTSAEHADALRSLAHGELMDRTAALGVNTPATTAVSGLTVDTVEEVLARVEHIAGLRAELPFGIDGIVVKADLAADQEAAGTGTRAPRWAIAFKLPAVEKITRLLDVEWNVGRTGIIAPRAVLEPVDIDGSTVTYATLHNPADITRRDLRLGDHVMVYKAGDIIPRIEAPVAHLRTGDEQSIAFPDVCPQCGSGIDTSEQRWRCERGRNCHLVASLSYAAGRDQLDIEGLGATRVVQLVDAGLVADLADLFALTRDGLLALDRMGETSTDNLLAAIEAAKAQPLSRVLCALGVRGTGRSMSRRIARHFATMDHIRAADAEAMQRVEGIGAEKAPVIVSELAELAPLIDRLAAAGVNMTEPGATPPAPEEETEKDGAGERAADAGPLDCMTVVVTGAMTGPLEKLSRNQMNELIERAGGKSSSSVSKRTSLVVAGEGAGSKRAKAEDLGIRLATPDEFAELVADLLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JXY0</accession>
    <name>A0A2M9JXY0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_12755</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN11724.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN11724">
        <property type="protein sequence ID" value="PJN11724"/>
        <property type="gene ID" value="CG723_12755"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002397">
        <property type="entry name" value="Cyt_P450_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00359">
        <property type="entry name" value="BP450"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="SSF48264"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0349">Heme</keyword>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN11724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="407" mass="44338" checksum="5753488EDBFDA89A" modified="2018-04-25" version="1">MGPQPVAIDPAGADVHAEAARLRASGPATLVRLPDGPEAWAVTSHSLLKDLLTDPRVSKDPNLHWPAWQRGEYHESWLATWVGVNNMFTAYGSDHRRLRKLIAPAFTARRTDAMLPSVERITAALLDELAAAPRGTVVDLREAFTHRLPMQVICELFGIPEGDTRAELARLSEIIMTSVDPQEAGAAFVEIQALLKGLAALKREEPASDLTSVLVAARDEEGRRMTEQELIDTLLLVLVAGHETTVNLIGNAVHALLTHPEQLELVRAGKLSWNDVIEETLRWAPSVVNLPLRFAVEDIEIPDGPTIRKGDPILASFAAAGRDPRQHGDTADQYDARRPSAEHLSFGHGVHRCLGAPLARMEAAIALPALFDRFPDLEFALPAESLEPAGGFIVGGLKAIPMRLTRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JYD3</accession>
    <name>A0A2M9JYD3_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Histidine kinase</fullName>
            <ecNumber evidence="3">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CG723_13705</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">CB01635</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="3"/>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN11880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN11880">
        <property type="protein sequence ID" value="PJN11880"/>
        <property type="gene ID" value="CG723_13705"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033463">
        <property type="entry name" value="sCache_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029151">
        <property type="entry name" value="Sensor-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016120">
        <property type="entry name" value="Sig_transdc_His_kin_SpoOB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039506">
        <property type="entry name" value="SPOB_a"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17203">
        <property type="entry name" value="sCache_3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14689">
        <property type="entry name" value="SPOB_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103190">
        <property type="entry name" value="SSF103190"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55890">
        <property type="entry name" value="SSF55890"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-0418">Kinase</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014786655" description="Histidine kinase" evidence="13">
        <location>
            <begin position="36"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="178"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="14">
        <location>
            <begin position="341"/>
            <end position="537"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="PJN11880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="548" mass="58244" checksum="C1A07F9C9480CB70" modified="2018-04-25" version="1">MVTTFRRHTLAGQMLVLQLAIVVVVLLAVAGVSLAQSEATFQRVEGRKVDALAEQLGANPLVRSQLVRPSPGEALAPLVHSTLAQSGVTSVTVADAQGRIVSSTNPTVVGERLSLGAGVARGRSWSGDLTLDGSRELVAQVPVLSAARRTLGQQLGTVMIGEASPTVWQRLSGTSSYLLAYLGIASGLGVMGSWLLARRVKRQTYGLEPREIAGLAEHREAMLYGIAEGVVALDPQLRLTLVNDVGRRLLDLPEDCVGQSIDDLGLEGRLRDVLVGARHGAADRHDQVVIRRGRLLVMNRMTVMKDGRLLGSVTTLRDRTELAELEREIGSFRSSSELLRAQAHEFANQLHTISGLIQIGEQDEVVRYIRALNQRRQSLDVTLARRVGDTAIAALLMAKSSLAAERKVSLRISAGTALGRLAPEDAADLATVIGNLVDNAVDAAASDDDTGDAWVEVELRQDASSVEVVVRDSGPGLPPEVAREVFAHGFTTKAAQEGERGIGLALTKLVCERHSGEISVANTADGAMFTAHMPLGHPADVAPEGVPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JYM4</accession>
    <name>A0A2M9JYM4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">LacI family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_14325</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN11983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN11983">
        <property type="protein sequence ID" value="PJN11983"/>
        <property type="gene ID" value="CG723_14325"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01381">
        <property type="entry name" value="HTH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="2">
        <location>
            <begin position="16"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="79"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN11983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="205" mass="22149" checksum="A4F54441F385C4F0" modified="2018-04-25" version="1">MSNMVDPLVAQIAARIRVERERRRWTLARLAEESGVSRAMIHRIERGESSPTAAILGKLSAAFQLSVSSLFALAEGAAEAPADGGSPVGESESGGVRRRGEAVEWTDPATGYRRRQITGLEFPTEVAEIRLPAGARVPYPAAAFAFLRQVVWVLDGHLTFHEGDAVHELDAGDTIELGEPSPRVFANTSTDECRYAVILARGTKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JYS4</accession>
    <name>A0A2M9JYS4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Cyclase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CG723_14595</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN12032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN12032">
        <property type="protein sequence ID" value="PJN12032"/>
        <property type="gene ID" value="CG723_14595"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004061">
        <property type="term" value="F:arylformamidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019441">
        <property type="term" value="P:tryptophan catabolic process to kynurenine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007325">
        <property type="entry name" value="KFase/CYL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037175">
        <property type="entry name" value="KFase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31118">
        <property type="entry name" value="PTHR31118"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04199">
        <property type="entry name" value="Cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102198">
        <property type="entry name" value="SSF102198"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PJN12032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="261" mass="27525" checksum="EC975240A5A71473" modified="2018-04-25" version="1">MSHPSVLAALTSALRSGSIEVVDLTAPLSSSTPVLQLPAQFGQTAVFELEEISRYDDRGPAWYWNNFRSGEHTGTHFDAPNHWITGKGLADVASVPAQQLIAPAAMLDFSVEAAANPDFLVEVEHVKAWEAQHGPLPDGGWLLLRTGWDDRSHAQQEFLNADENGPHTPGLSAECARWVAEEAPVIGLGVETVGTDAGQAPGFDPAFPCHSFLMGSGKYGLTQLQNLAALPPTGAVVLAGPLPIVTGSGAPARVLALVERA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JZ41</accession>
    <name>A0A2M9JZ41_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CG723_14565</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN12027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN12027">
        <property type="protein sequence ID" value="PJN12027"/>
        <property type="gene ID" value="CG723_14565"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016847">
        <property type="entry name" value="Man6P_Isoase_Firm_lng_prd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF026713">
        <property type="entry name" value="PMI_Firm_long_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PJN12027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="564" mass="61892" checksum="1613805D530F5858" modified="2018-04-25" version="1">MYRLDPRYAPAPQAVLSTGWQAVAAQLPTGPAVLAVEGSPSVDWDALGEQLRSELAARGIPVALLDVRAHYAPPAEIRKRTERPEDEEDPYFRKLADNPLDDLFDTLPTPTPPDEGLLIVHGPGAALVDHDLLWYADVPKRYAEAAAVAGAGGVNLGLPGEKPDLQRLFYSDWPMLDRQRDALAHRLDGWLDVQNPEHPVSLDGPGLRATYAALASRPVRTRPYFNSTPWGGHWAQRTLGINPDARNTALGYELIAPEAGILVGTGPLAQAEVPFQLMCALEPDRVLGQEVHTRFGTSFPLRFDYLDTVGGGNLSLHCHPKEPYMRERFGWPYTQHETYYMTLGSPDTKVFLGLREDADVEAFRGQVRQAATDGTPLEVEDHVLTFPAEQGQLFMIPAGTPHASGAGNLVLEISATPYLYSLRFYDWLRPDADGNPRPLPYEHGFANLETGRRGDAVARDLVQQPRTLRTGAGWREEVIGALEEMFYEVRRYVLDAGAEADDDTAGRFHILNVVEGEGVSVHTAAGDRHELAYAETLTVPAAVGRYSVRAANGGPVRVVKALVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JZ97</accession>
    <name>A0A2M9JZ97_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Probable membrane transporter protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CG723_12520</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CB01635</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the 4-toluene sulfonate uptake permease (TSUP) (TC 2.A.102) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN12186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN12186">
        <property type="protein sequence ID" value="PJN12186"/>
        <property type="gene ID" value="CG723_12520"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002781">
        <property type="entry name" value="TM_pro_TauE-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01925">
        <property type="entry name" value="TauE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="29"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="69"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="98"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="137"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="183"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="231"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PJN12186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="250" mass="25470" checksum="AE08D8BD993B8C9A" modified="2018-04-25" version="1">MVAVCAAGVGAGAINTAVGSGTLITFPVLLATGLPPVTATVSNALGLIPGSISGAVGYRTELAGQRRRILKLGGGAVLGGFAGATLLLTLPATAFETIVPLLVGLAVVLVAFRPLISGRVRRRRERSGARPRGDVGPLLFTSLTLASVYGGYFSAAQGILYVALMGMLLDEPLQRLNAVKNVLVALVNAVAALFFLFVADFDWTAVLLIAAGSALGGQLGAKAGRRLSPGVLRALVVTVGTFAVVQLLLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JZE3</accession>
    <name>A0A2M9JZE3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_09895</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN12127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN12127">
        <property type="protein sequence ID" value="PJN12127"/>
        <property type="gene ID" value="CG723_09895"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyr_redox_2" evidence="1">
        <location>
            <begin position="9"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN12127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="419" mass="43229" checksum="824A2FEDA239A2CF" modified="2018-04-25" version="1">MTRRQRSVDVVVVGAGPAGLAVARSLAEDGVGVVEILEREAVAGGVPRHCHHRGFGRWGVTGPQYAARTVEAALGSGARVRTGVTATGWAGPLTLDTTGPHGLERITARAVVLATGARERPRSARLVPGTRPAGVLTTGELQQAVHLHGQPVGSRAVVVGAEPVSYAALAALRRADVTVVALTTEEPRHQLGRARAAAARIGHGVPVLTGATVAELLGKGRVSGVRLRHRDGRLTTVGCDTVVFTGDFVPDHELARRGGVALDAGTRGPAVDGAFRTGVPGVFAVGNVLHAVEPALWTAREGALAADAVREFLEGAGPAPGGPAIEVAAPLRWVAPNRVAPQVPVDGFVLRTAEVLVRPVLVVTQDGRRLHRQYVPRGALPNRTLHLAGAWTGKVDAMGGPVRITVGGLRGHRSGASSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JZG3</accession>
    <name>A0A2M9JZG3_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CG723_10920</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CB01635</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN12147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN12147">
        <property type="protein sequence ID" value="PJN12147"/>
        <property type="gene ID" value="CG723_10920"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="8">
        <location>
            <begin position="1"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="264"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="365"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="375"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="397"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="436"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="25"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PJN12147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="552" mass="56646" checksum="CF956628D76C27C5" modified="2018-04-25" version="1">MIGRGGMGVVARAVDELLNREVAVKILRAFTDSSASDLAGLRVRMQREAQAAARIRHSGVVTVHDVTEEEGLPVIVMELVDGPSLDDVLTERGALEPHEAAAIGAKLMDALDAAHRAGVLHRDVKPGNVLLEDGGRVVLTDFGIASMEAAGDDAMDKLTRSGQLVGSLDYLPPERAQGKEPGPASDIWSLGMTLYAAVEGTSPFRRTSVWSTLAAIVNEPLPESGRAGALAPVLRALMAKDPESRPDAGQAREMLERVAAGSTVSFGPPAQAQAPAVAPAPHTVHQSGPGFGSPAAPYPQPPQGGGYPTPGLASTLPRTGEPHVGRAASRASGRARRRSRAVIASTAAAVVIAGGGITYALVGTGGDTKSDEARTAPTRSGASQVSDLPSRGSVGGGEKSPSASSSATSQAPSRTPSQRPSEAGGEGAGDTKDGGESSARPSNDGGTTASQPPAPPTAKPSSVSKSCSGWTHRDPNPGTYGYMSGSYHIVTGPYQTCSSVALAENGSKLWYHCSVVNAYGHNWTYVRVAGTNTSGWMSNDNLTNQSGASTRC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JZQ6</accession>
    <name>A0A2M9JZQ6_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 8">Pyruvate dehydrogenase E1 component</fullName>
            <ecNumber evidence="2 8">1.2.4.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">aceE</name>
        <name evidence="12" type="ORF">CG723_04595</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">CB01635</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7 8">
            <text>(R)-N(6)-lipoyl-L-lysyl-[dihydrolipoyllysine-residue acetyltransferase] + H(+) + pyruvate = (R)-N(6)-(S(8)-acetyldihydrolipoyl)-L-lysyl-[dihydrolipoyllysine-residue acetyltransferase] + CO2</text>
            <dbReference type="Rhea" id="RHEA:19189"/>
            <dbReference type="Rhea" id="RHEA-COMP:10480"/>
            <dbReference type="Rhea" id="RHEA-COMP:10481"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:83099"/>
            <dbReference type="ChEBI" id="CHEBI:83111"/>
            <dbReference type="EC" id="1.2.4.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.2.4.1" evidence="2 8"/>
    <dbReference type="EMBL" id="NNBL01000002">
        <property type="protein sequence ID" value="PJN12338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN12338">
        <property type="protein sequence ID" value="PJN12338"/>
        <property type="gene ID" value="CG723_04595"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004739">
        <property type="term" value="F:pyruvate dehydrogenase (acetyl-transferring) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02017">
        <property type="entry name" value="TPP_E1_EcPDC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035807">
        <property type="entry name" value="PDC_E1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004660">
        <property type="entry name" value="PDH_E1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041621">
        <property type="entry name" value="PDH_E1_M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009014">
        <property type="entry name" value="Transketo_C/PFOR_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005474">
        <property type="entry name" value="Transketolase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43825:SF3">
        <property type="entry name" value="PTHR43825:SF3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17831">
        <property type="entry name" value="PDH_E1_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00456">
        <property type="entry name" value="Transketolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000156">
        <property type="entry name" value="Pyruvate_dh_E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52922">
        <property type="entry name" value="SSF52922"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00759">
        <property type="entry name" value="aceE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8 12" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0786">Thiamine pyrophosphate</keyword>
    <feature type="domain" description="TRANSKETOLASE_1" evidence="10">
        <location>
            <begin position="151"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="domain" description="PDH_E1_M" evidence="11">
        <location>
            <begin position="490"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="245"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="275"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="277"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00033635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR000156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000156-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF17831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PJN12338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="915" mass="101612" checksum="E303A2C2C3115C4A" modified="2018-04-25" version="1">MVSGSDRNPIIIGGLPSQVPDFDPEETQEWLDSLDAAVDERGRERARFLMLRLIERAREKRVAVPEMRSTDYINTIATKDEPFFPGNEEIERKVLNATRWNAAVMVSRAQRPGIGVGGHIATFASSASLYDVGFNHFFRGKDDGTGGDQIFFQGHASPGIYARAYLLDRLTDGQLDSFRQEKSKAPYGLSSYPHPRLMPDFWEFPTVSMGLGPLGAIFQARMNRYMQARDIADTSASHVWAFLGDGEMDEPESLGQLSIAAREGLDNLTFVVNCNLQRLDGPVRGNGKIIQELESQFRGAGWNVIKLVWDRSWDPLLAQDRDGVLVNKLNTTPDGQFQTYATEPGSYIRDHFFGGDHRLRAMVENMTDDQILHLGRGGHDHKKIFAAFKAAKEHKGQPTVILAQTVKGWTLGPNFEGRNATHQMKKLTVDDLKGFRDRLHLPITDKQLEDGAPPYYHPGRDSEEIQYMHDRRHALGGYVPTRVVRSKPLPLPDDKTYASVKKGSGQQSIATTMAFVRLLKDLMRDKEIGRRFVLIAPDEYRTFGMDSFFPSAKIYNPLGQQYESVDRDLLLAYKESPTGQMLHDGISEAGCTASLIAAGSAYATHGEPLIPVYVFYSMFGFQRTGDQFWQMADQLARGFVLGATAGRTTLTGEGLQHADGHSQLLASTNPACVAYDPAFGFEIAHIVQDGLRRMYGATAEHPHGEDIFYYLTVYNEPLQHPAEPADVDVEGILKGIHRFSPGTSGTTPAQILASGVAVPWALEAQQILAAEWNVRADVWSATSWNELRREAVEVERHNLLHPDEEQRVPYVTRKLSGSEGPFVAVSDWMRSVPDQISRWVPGTYQSLGADGFGFADTRGAARRFFHIDAQSIVVGVLTELARDGKIDRSVLKQAIDRYQLLDVSAADPGPAGGDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-09-29" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JZV6</accession>
    <name>A0A2M9JZV6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CG723_05095</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CB01635</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000002">
        <property type="protein sequence ID" value="PJN12422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN12422">
        <property type="protein sequence ID" value="PJN12422"/>
        <property type="gene ID" value="CG723_05095"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004638">
        <property type="entry name" value="EmrB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00711">
        <property type="entry name" value="efflux_EmrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="21"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="58"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="90"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="115"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="149"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="177"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="210"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="236"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="280"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="309"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="339"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="372"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="415"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="446"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="24"/>
            <end position="472"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PJN12422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="479" mass="48311" checksum="08AAA379C1C6BFCD" modified="2018-04-25" version="1">MTLMLEAPADIAISRKAAPPTWLIVAAACAGQFLVVLDVSVVNVALPSMRADLGLSATGLQWVVNAYSIAFAGFMLLGGRAGDLFGRKRMFLVGLGLFTLASLAGGLAQEGWQLLAARAVQGLGAAVLAPSTLTILTSAVPEGAARARAIATWTAVGAGGGAAGGLVGGVLTEGLDWRWVLLINVPLGALVLTAAARWIQESKAGGERRLDLPGAVLVTAGTATLAYGVVQTEAEGWGAAATLVPLGVALALIVTFLAVEARTRLPLMPLGLFRVRAVAAANAAMFVCGMGSFAMWFFMTLYAQNVLGYTPIEAGLALVPSSLAVVAGSKIAPRLMRRAGARAVAVSGVLITAAGFTWQSTMGPHGGYVTGIMLPGMVMMAGAGLAMTPLASLATSGAAPGDAGLVSGLVNTSRTLGGSLGLAILSTVAAGHSAGGTGPEDLTDGYAAAFRWGAGILLVAVVLLVTWMPRAKEARQPAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JZW8</accession>
    <name>A0A2M9JZW8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Acyl-CoA dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CG723_05060</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CB01635</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000002">
        <property type="protein sequence ID" value="PJN12416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN12416">
        <property type="protein sequence ID" value="PJN12416"/>
        <property type="gene ID" value="CG723_05060"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016627">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="SSF47203"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="SSF56645"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA_dh_N" evidence="7">
        <location>
            <begin position="6"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_1" evidence="5">
        <location>
            <begin position="219"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_N" evidence="7">
        <location>
            <begin position="393"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_M" evidence="6">
        <location>
            <begin position="475"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_1" evidence="5">
        <location>
            <begin position="583"/>
            <end position="724"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PJN12416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="729" mass="75806" checksum="683ADAD23B22BDD5" modified="2018-04-25" version="1">MGIAITQEQEELAGAVRGWLARAVPPEEVRKLLDAPAAPAGRPAHWDGLAGQGLLGLHLPEEYGGGGGDLVDLAVVLEEAGRAALPGPFAASAAASLVLRHAGAAGLAASLASGDRIGAAALGTGTLTAVTVSDGLVLDGVAPPVLSGGDADLLLLAAESATGTVWVAVDAGTAGIGVRVHESADPTRPTAEITARGALVPAVRILAVDTATVRDLASVVLAADACGVAAWALHMAAEYAKVREQFGRPIGQFQGVKHLCADMLVRVEQARALVWDAARAAGGGAEGADDGAARELVVSLAAGAALDAAYSCAKDCVQVLGGIGFTWEHDAHLYLRRAVVARQLLGAGDTHRLRAVRLAEGGARRELRLELPAEAEAFRAGAREAVEGMRGLDPAAARRALAPTGYAAPHLPEPYGLGAGPVQQLAVQQELAAAGVRVSDLGIGTWVVPSLLAYGTPEQRDRYLLPTLLGDVLWCQLFSEPGAGSDLASLRTKAERTEDGRWRVNGQKVWTSAAQWADHGILLARTNPDAPKHKGLTYFVVDMKRTDGIDVRPLKEITGDSLFNEVYFDDVLLPEDAVVGQVDDGWRVARNTLGNERVHMADQLTFDTGLEALIARAGTLDGAYRARIGALATEAHALACTGLRTTMRQVAGADPGPGASVRKLVQTPHQQKVAELALELLGPEGALREGAGERALHGFLMSRCLTIAGGTTQVQLNVVAERILGLPRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K026</accession>
    <name>A0A2M9K026_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CBM-cenC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CG723_05415</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000002">
        <property type="protein sequence ID" value="PJN12476.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN12476">
        <property type="protein sequence ID" value="PJN12476"/>
        <property type="gene ID" value="CG723_05415"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0110165">
        <property type="term" value="C:cellular anatomical entity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016798">
        <property type="term" value="F:hydrolase activity, acting on glycosyl bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003305">
        <property type="entry name" value="CenC_carb-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02018">
        <property type="entry name" value="CBM_4_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="SSF49785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="SSF51126"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014922454" description="CBM-cenC domain-containing protein" evidence="2">
        <location>
            <begin position="35"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="domain" description="CBM-cenC" evidence="3">
        <location>
            <begin position="534"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="30"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="552"/>
            <end position="576"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PJN12476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="665" mass="68564" checksum="F27D82B861BB8F1B" modified="2018-04-25" version="1">MAPVTSGLRRACTTLAAGLALAASALVSPPGAQAAGSAHPGHPPHPSQSASTPHYVDCSAAANGDGSLAAPYNSLAAANAVTYGPGDRLYFKRGSTCRGQLKPAGSGSAAAPVRVAPYGSGGARPVIEGGGTVYAAVHLLNVEQWEIRGLEVTNKGAADAERNGILVELADHGTGTHYVLDDVYVHDVNGGDTKSSNGIQFRVSGTVTPTRFDDVLVQNSEIYKVDREGLTTQSSWACRAVYGCTSGPAWTASTRVVFRGNKIHDIGGDGMVVRVTRDALAEHNEAYDIWMRSAGNNAGLWTINSDGTVFQYNEVHHVRRTAGMNDGMAFDADFGTRGAVFQYNYSHDNEGGFLLLCGACGSGADTAGTVARYNLSVNDGSRILYAVGDAAAQILNNTFYMGAGSTTSVVESSGGASTTLWSNNIFYNLGTGGYGGKPAEHTWRNNVMYGNHPASEPADPGKVTADPLLVDPGSADPAGYKLKAGSPARGAGQVTTGSGGKDYFGSPAPVACRPDIGAHQVSAFDDAACSGGTNLVANPGFETGVPPWAPSGAVAADTANPHGGGSSLRVSGTPSTAEQKITVAPNTTYTLSGWGRVDAYDTQLAVGVKNFGGAETRIPAFSAFGWRTGSITFTTGATNTSATLYCYTRTGKGSGWCDDLRVVKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K070</accession>
    <name>A0A2M9K070_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Beta-N-acetylhexosaminidase</fullName>
            <ecNumber evidence="3">3.2.1.52</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CG723_05690</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CB01635</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal non-reducing N-acetyl-D-hexosamine residues in N-acetyl-beta-D-hexosaminides.</text>
            <dbReference type="EC" id="3.2.1.52"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 20 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.52" evidence="3"/>
    <dbReference type="EMBL" id="NNBL01000002">
        <property type="protein sequence ID" value="PJN12525.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN12525">
        <property type="protein sequence ID" value="PJN12525"/>
        <property type="gene ID" value="CG723_05690"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004563">
        <property type="term" value="F:beta-N-acetylhexosaminidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102148">
        <property type="term" value="F:N-acetyl-beta-D-galactosaminidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.379.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025705">
        <property type="entry name" value="Beta_hexosaminidase_sua/sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015883">
        <property type="entry name" value="Glyco_hydro_20_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029018">
        <property type="entry name" value="Hex-like_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015882">
        <property type="entry name" value="HEX_bac_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22600">
        <property type="entry name" value="PTHR22600"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00728">
        <property type="entry name" value="Glyco_hydro_20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02838">
        <property type="entry name" value="Glyco_hydro_20b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00738">
        <property type="entry name" value="GLHYDRLASE20"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="SSF49899"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55545">
        <property type="entry name" value="SSF55545"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glyco_hydro_20b" evidence="7">
        <location>
            <begin position="2"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_hydro_20" evidence="6">
        <location>
            <begin position="152"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="26"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PJN12525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="702" mass="76241" checksum="CA718F8110C21F23" modified="2018-04-25" version="1">MVPRPADWTSLGGTVAITHRTRVLVDPRARAETSEPSGRAEFPGPARQSVQQLAAQLRTEIDQVSGIEPRIASDVAHAGPGDIVLGLADDRELGAEGYRFDSSDGAVRIRAASTHGLFYGTRTLLQLLRSTADEHRTLPRARATDVPTQAIRMVHLDAGRKYWKIPYLENLIRRMGDQKLNTLMLHLSESEGFRLYSPKFPGLADPDHSYSRADIEHLKAFAARHHVQLMPGLEIPGHATAISDAFGIGFGSGTNPCTAAHTHSHLTPDWIIDMTSEKAVAKTKQIVDEFAGWFDAPLFSIGGEEVPGQLADCPRVQDYLAASPDVSTLGDLLNRYINTLDDVIASHGKRTAVYNGSEHLAAPQQTVHGPVVFITWEGTGAEPAVPGHDEIAIGPFYDTPNNYHHLYPNEPWMYDSWTVSTAPDMLGSGLTNWADYNFWADDAYFEQSMAGARAILADRAWNGTATPDTLADFRARAALIGGPPGITTTPVEPRVNDGRPSHHWTFDPAAYPKGWTYAGSPGNTIFAEDTAGDLPGTSYIINNPAPVTDGVRGQAWRFDSDRDGVGFGGMDVAEPWTVSVQVRPTARTADQVLLSSKAGALKLMQYGTGKVGFTRYGSADLSFDYTLPLDRWTRLTWVATPGHTTLYADGERVGTVDASIPLPLRSIGTEKVSLRGDLDELTTWDEPLTAGRIAGLSGKDTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K0L6</accession>
    <name>A0A2M9K0L6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Rhomboid family intramembrane serine protease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CG723_06565</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CB01635</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000002">
        <property type="protein sequence ID" value="PJN12681.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN12681">
        <property type="protein sequence ID" value="PJN12681"/>
        <property type="gene ID" value="CG723_06565"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022764">
        <property type="entry name" value="Peptidase_S54_rhomboid_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035952">
        <property type="entry name" value="Rhomboid-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01694">
        <property type="entry name" value="Rhomboid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144091">
        <property type="entry name" value="SSF144091"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="71"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="183"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="208"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="237"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="259"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="282"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="domain" description="Rhomboid" evidence="6">
        <location>
            <begin position="134"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PJN12681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="304" mass="32636" checksum="5B02C0449C549303" modified="2018-04-25" version="1">MEAESQPATTPAVTTCYRHPKVETYVSCTRCERPICPDCMRSAAVGHHCPDCVKEGVRSVRQARTVFGGRVSAVPLVTYVLMGLNIVAYLAELVRPAVVDRFGMLGAGLVGPDGGHYVYQDGFPADFHAEGVVAGEWYRMITGAFLHMPATEGVFGILHILFNMYSLWNLGRVVETQLGRVRYLAVYFLSAFGSSVLVYLIAPGTLTVGASGAIFGLGAAYYVMARRLGADMSGVNRFMAYFLLWMLISAGFASWQGHLGGLLTGGAATIALAYAPRARRTLVQGSACAALLVLLVALTLLKQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K0X1</accession>
    <name>A0A2M9K0X1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">SAM-dependent methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_07075</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000002">
        <property type="protein sequence ID" value="PJN12766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN12766">
        <property type="protein sequence ID" value="PJN12766"/>
        <property type="gene ID" value="CG723_07075"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransf_11" evidence="1">
        <location>
            <begin position="48"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN12766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="265" mass="29226" checksum="370B36534780354D" modified="2018-04-25" version="1">MTRPEGYLLDNQQQEAGRRFDAFSTLFDPTTFRHIEQLGIGPGWRCWEVGAGGTSVVSWLAKKVGPTGRVLATDIDTSWQTSAARSPIEVRRHDVAADEPPAEGFDLVHARLVLVHVPDRERALKSMLRALRPGGRLLVEDADPALQPLACPDEHGPAEELANRLRRGFRKLLAERGADLSYGRRLLRLLREAGLHQVEADAYFPLTSEACGALETATFQQIRESLVRAGHATDEEIDRHLADVATGTMDLATAPLISAWGRKRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-09-29" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K0Z4</accession>
    <name>A0A2M9K0Z4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_06925</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000002">
        <property type="protein sequence ID" value="PJN12740.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN12740">
        <property type="protein sequence ID" value="PJN12740"/>
        <property type="gene ID" value="CG723_06925"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="77"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN12740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="122" mass="13508" checksum="A31B08B531311A34" modified="2018-04-25" version="1">MPHSNPETHVIDFRAAEQLLAARDPRGAVKLLDPVIAAHPENTAARLLRARAFFASAQLRAAELEFTIVLEREPDNAFAHFALARTYQRAARPDQARRHFRLAAALDPQPDYVAAAAFDDAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K139</accession>
    <name>A0A2M9K139_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CG723_07450</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000002">
        <property type="protein sequence ID" value="PJN12838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN12838">
        <property type="protein sequence ID" value="PJN12838"/>
        <property type="gene ID" value="CG723_07450"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PJN12838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="480" mass="50397" checksum="D8AD39393A61DE70" modified="2018-04-25" version="1">MSDSSPLPPARLRSEAELARDALATPLLSRAVRLARWAGPATRVGAGGELVEEQLPAAALELGLGADAEGAADASEAWRVAVDTGLVEIVDEEEGTVAAGEDLAVVASGSPQDILALWLGALDTALADASIPDLDDLVDVLEETGEVDFSQLDWDPEAEAEFLEGVLGNLYLLTVTEGGAGDEPVPLPALAASMIVPDDMGEPTDDVLEQVSDAMLKLDDQFRLLVPVGLVEYQPVDEALMAEIGEGEGVNEPEAFDDSDVTRYGMVRLTPLGLHGVRARMIDAGLDAPVVGDLADKGADTLLDGTSSFPQAAAQAEIEQWLARRQPLVAARELLAAARGADAGAPLRRLRCQQALSLVGREAEPALREVLDDAELGGLARVWLAEHGASDVPAPPESLIFWLTVDTIAAQLALEGNSDELQGLVEGLAAQHRGFFAAAWKVEHPATADVLEAMGRLHPDKKVAKEARKAAFKARSAQGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-09-29" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K171</accession>
    <name>A0A2M9K171_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Aldehyde dehydrogenase (NADP(+))</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CG723_07605</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000002">
        <property type="protein sequence ID" value="PJN12869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN12869">
        <property type="protein sequence ID" value="PJN12869"/>
        <property type="gene ID" value="CG723_07605"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016620">
        <property type="term" value="F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07129">
        <property type="entry name" value="ALDH_KGSADH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044151">
        <property type="entry name" value="ALDH_KGSADH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="SSF53720"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldedh" evidence="3">
        <location>
            <begin position="8"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="485"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="496"/>
            <end position="510"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PJN12869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="510" mass="52741" checksum="6DD96F5F6E7D7FF9" modified="2018-04-25" version="1">MAAAPVWSVDPRTGKQREQVAVEATAEEVDQAVRAAHAATGALADRTVRAAFLRSAAELLDASKDHLVEAADAETALGPVRLTGELARTSYQLRAFADIVDEGAFLGIVIDHPDDSATPPIPDLRRYKVPLGVVAVYSASNFPFAFSVPGGDTASALAAGCPVVVKAHPDHPATSELVASVLRRAAAQHGIPEGVLGLVHGFEAGVELVKHPLVSAAGFTGSVRGGRALFDAAAARPVPIPFHGELGSLNPVVITAEAAAERAEQIGAGLAGSMTLGVGQFCVKPGLVFAPNGADGDRLVKSLTDAVSDTDAGVLLDHRMRDNFVAGVAERAELPDVDAPVTPGAGSEHTVSPGFLTVPAQRLATDGGDHDLLLEECFGPVTVVARYEDDAEVTSVLSRLPGNLSATVHLSEGEAAGQGRGAEILAELTPLAGRVLVNGWPTGVAVAPAQHHGGPYPATTSTSTSVGGTAVERWLRPVAYQNTPEALLPPELRDDNPLGLPRRYEGRQEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K1A2</accession>
    <name>A0A2M9K1A2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_07510</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000002">
        <property type="protein sequence ID" value="PJN12850.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN12850">
        <property type="protein sequence ID" value="PJN12850"/>
        <property type="gene ID" value="CG723_07510"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN12850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="100" mass="10405" checksum="E8E9958AD0108497" modified="2018-04-25" version="1">MNDRIEADDAEPCEPTPAGPLFVPVRPGPGTCATRLFRTARGGRTAVGFTSERLLVDLLGPGQPWIRLAEPALRALTGPVGVTELTVDPSPAPAPAGHRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K1F3</accession>
    <name>A0A2M9K1F3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_08070</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0098 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000002">
        <property type="protein sequence ID" value="PJN12949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN12949">
        <property type="protein sequence ID" value="PJN12949"/>
        <property type="gene ID" value="CG723_08070"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00865">
        <property type="entry name" value="PEBP_bact_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.280.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008914">
        <property type="entry name" value="PEBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036610">
        <property type="entry name" value="PEBP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005247">
        <property type="entry name" value="YbhB_YbcL"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30289">
        <property type="entry name" value="PTHR30289"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01161">
        <property type="entry name" value="PBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49777">
        <property type="entry name" value="SSF49777"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00481">
        <property type="entry name" value="TIGR00481"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN12949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="179" mass="18938" checksum="EF7126CA0E3952FE" modified="2018-04-25" version="1">MTDLKRPPLPHDFHPQVPSFTVASEDFEPGAVLKDAQVYAAGNTSPQLRWEGFPAGTKSFAVTCFDPDAPTGSGFWHWTVFDIPVAVTELAAGAGSGKFEGLPAGAVQVRNDYGTKDFGGAAPPPGDPAHRYVFTVYAVDQEKLGPDSDASPAVVGFNLRFHTLARAQVIAEYAASADS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K1G2</accession>
    <name>A0A2M9K1G2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_04895</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000002">
        <property type="protein sequence ID" value="PJN12973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN12973">
        <property type="protein sequence ID" value="PJN12973"/>
        <property type="gene ID" value="CG723_04895"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="SSF54427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014948609" evidence="1">
        <location>
            <begin position="24"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN12973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="152" mass="16256" checksum="8D8C843876BC39E2" modified="2018-04-25" version="1">MLVLAGAGLLVKAQELRSTPAAANHALTDTEATTRVNGDVSSALARIFSYTPDGTGATERSARELLGGRAARQYTQLFAQVHARVADQRITLTTQSVRSGVVSLDGDSAQLLVFLDQTARRGDRKPTSSAAQLSVTARLRGDHWQIVDIKAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K1M9</accession>
    <name>A0A2M9K1M9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_07985</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000002">
        <property type="protein sequence ID" value="PJN13033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN13033">
        <property type="protein sequence ID" value="PJN13033"/>
        <property type="gene ID" value="CG723_07985"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN13033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="71" mass="7434" checksum="117E2CBEB0225937" modified="2018-04-25" version="1">MSAPTHTRPHPAPAGGVDVRLPWWAIALPAITFAVLLLLIINPADAHAATGDPAVGQLLDRIQQAVLRTAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-06-02" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K1T2</accession>
    <name>A0A2M9K1T2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_00270</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000001">
        <property type="protein sequence ID" value="PJN13078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN13078">
        <property type="protein sequence ID" value="PJN13078"/>
        <property type="gene ID" value="CG723_00270"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="SSF50494"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014773748" evidence="2">
        <location>
            <begin position="48"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="43"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="111"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="112"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN13078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="408" mass="43168" checksum="EC5132440A20B50F" modified="2018-04-25" version="1">MRPIRPLLTVQLGRSVRRRTSPVAAALAIGAALALTATACGPGDDNADSKPTAAATQGGSDKIQIPDDIKDRLKEHGIDLDKWKNGEWKNWDKDKWLREAQDYVNPIIDGLWDPDRMRDADKNPDNEVDDNDISGDQGVTDPTPQPVKAAAVGTPYHDSAPYAGKLFFDGPEGSMVCSATVVTDPAHPGKSNMVWTAGHCVHAGKNGGWYRNIAFVPSYNNAGLSDEQLKTATKEEVAPYGVWWGAWAQTSDQWIEQGGPTGGQGAPYDFAVIQVTPEKGSEGKSLEEAVGTAVPVDFNAPAVPKIATMTAKGYPAAPPYDGQTLYQCADKPGRLSLAKAEPTMYRIGCTMTGGSSGGGWIAQGSSGKPSLVSNTSIGPVTAGWLAGPRLGKEAKGIYDAVSKKYAGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K1Y5</accession>
    <name>A0A2M9K1Y5_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Inositol-1-monophosphatase</fullName>
            <ecNumber evidence="5">3.1.3.25</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CG723_00585</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CB01635</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 5">
            <text>a myo-inositol phosphate + H2O = myo-inositol + phosphate</text>
            <dbReference type="Rhea" id="RHEA:24056"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17268"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:84139"/>
            <dbReference type="EC" id="3.1.3.25"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the inositol monophosphatase superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.25" evidence="5"/>
    <dbReference type="EMBL" id="NNBL01000001">
        <property type="protein sequence ID" value="PJN13133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN13133">
        <property type="protein sequence ID" value="PJN13133"/>
        <property type="gene ID" value="CG723_00585"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008934">
        <property type="term" value="F:inositol monophosphate 1-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052832">
        <property type="term" value="F:inositol monophosphate 3-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052833">
        <property type="term" value="F:inositol monophosphate 4-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046855">
        <property type="term" value="P:inositol phosphate dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046854">
        <property type="term" value="P:phosphatidylinositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01639">
        <property type="entry name" value="IMPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033942">
        <property type="entry name" value="IMPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020583">
        <property type="entry name" value="Inositol_monoP_metal-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000760">
        <property type="entry name" value="Inositol_monophosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020550">
        <property type="entry name" value="Inositol_monophosphatase_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00459">
        <property type="entry name" value="Inositol_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00377">
        <property type="entry name" value="IMPHPHTASES"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00629">
        <property type="entry name" value="IMP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00630">
        <property type="entry name" value="IMP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU364068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PJN13133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="265" mass="28022" checksum="257A526FFCA84F2F" modified="2018-04-25" version="1">MTDLKAELLEVALEAAARAGTFLRDGRPADLGVAATKTSAVDVVTEMDIASEKLITGFLAERRPDDGVLGEEGASTEGSSGITWVIDPIDGTVNYLYGRPEWSVSIAALQGDETLVGVVAAPLRGETYRAVLGQGAYVNDRPAHARVAPPFEQALVGTGFGYLAARRAHQADVVRELVPHVRDIRRGGSAAIDLCDVAVGRLDAYYERGLNPWDLAAGDLIAREAGALTGGRPGEVPSGELTIAAPPGLFEQLQNRLEELGAWHD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K209</accession>
    <name>A0A2M9K209_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Transcriptional regulatory protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CG723_00460</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CB01635</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000001">
        <property type="protein sequence ID" value="PJN13110.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN13110">
        <property type="protein sequence ID" value="PJN13110"/>
        <property type="gene ID" value="CG723_00460"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013196">
        <property type="entry name" value="HTH_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024187">
        <property type="entry name" value="Sig_transdc_resp-reg_cit/mal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45526">
        <property type="entry name" value="PTHR45526"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08279">
        <property type="entry name" value="HTH_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006171">
        <property type="entry name" value="RR_citrat_malat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0010">Activator</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0902">Two-component regulatory system</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="3"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="3">
        <location>
            <position position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRNR" id="PIRNR006171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PJN13110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="226" mass="24789" checksum="FD346E3CF826611A" modified="2018-04-25" version="1">MIEVLVVDDDIRVARVNAAYVQKVAGFRVVAEAHSSAEALREVEARPQIDLILMDHYLPDETGLATVQEIRRRGHQTDVIMVTAARDVSTVQAAMRLGALQYLVKPFAFAGLRAKLEAYAGLRRTLDGGGEAEQAQVDRIFGALSADTEPDLPKGHSLSTAELVRRALVDAEGPLSAQEVADRTGLSRQTAQRYLKLLERTGRAGLTLKYGDAGRPEHRYVWATRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K316</accession>
    <name>A0A2M9K316_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glyoxalase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_02875</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000001">
        <property type="protein sequence ID" value="PJN13521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN13521">
        <property type="protein sequence ID" value="PJN13521"/>
        <property type="gene ID" value="CG723_02875"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VOC" evidence="1">
        <location>
            <begin position="2"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN13521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="119" mass="12525" checksum="82312135B65C4811" modified="2018-04-25" version="1">MEILGTTLRICVEDLESSVAFYERLAGSRALRFERGGVSVAAVGCFLLMSGPKEEIDVLRKVSATIAVPNVDEAHAVLSASGARVLAGPVPTPAGRNLIAMHPDGSVFEYADRQGQAQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K3S6</accession>
    <name>A0A2M9K3S6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Bile acid:sodium symporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_03015</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000001">
        <property type="protein sequence ID" value="PJN13784.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN13784">
        <property type="protein sequence ID" value="PJN13784"/>
        <property type="gene ID" value="CG723_03015"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038770">
        <property type="entry name" value="Na+/solute_symporter_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016833">
        <property type="entry name" value="Put_Na-Bile_cotransptr"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18640">
        <property type="entry name" value="PTHR18640"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13593">
        <property type="entry name" value="SBF_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF026166">
        <property type="entry name" value="UCP026166"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="38"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="70"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="103"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="135"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="169"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="232"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="277"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="325"/>
            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN13784.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="346" mass="36240" checksum="A2AE42580ADBE1CF" modified="2018-04-25" version="1">MKRLTWPSWMPVDPYILALIGTVGLAALLPARGGAADVASGASTTAVAFLFFLYGARLSTREALDGLRHWRLHVTVLAATFVVFPLLGLAARGLVPVVLTPSLYDGLLFLTLVPSTIQSSIAFTSMARGNVPAAICAGSFSSLAGIVITPLLAAGLLGNSGGGFSADSLVKIVLQLLVPFLAGQFLRRWVGSFITRHKKVLSYVDRGSILLVVYTAFSEGMVQGIWHQVSAVRLGGLLAVEAVLLAVMLAVTWYGGKALGFGREDSVAIQFAGSKKSLAAGLPMASVLFGAHASLAVLPLMLFHQMQLMVCAVIAKRRARDPLEQVSAGERAAAPRTAAGTATRSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K3W5</accession>
    <name>A0A2M9K3W5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CG723_03920</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CB01635</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000001">
        <property type="protein sequence ID" value="PJN13812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN13812">
        <property type="protein sequence ID" value="PJN13812"/>
        <property type="gene ID" value="CG723_03920"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="9"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="71"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="107"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="133"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="191"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="251"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="72"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PJN13812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="286" mass="30851" checksum="B8A2451AAACDB7F6" modified="2018-04-25" version="1">MEKPTRTGLFLKGLVLVLVVAAVAYPLLGVIGTSFASQSDIIRSPGLVLWPDHPTLEAYRTVFSGGVVTHALLVSVGVTLVGTATSVLVTIGMAYGLSRREVTGSRFILMTALITMLFDPGIIPKFLTIKELGLYNTLASLVLPTMVSAFNLVVLRSFFMNLPEELYDAAKVDGAGDLRTLVRIVLPLSKAVIAVISLFYAVTYWNAFFNAMLYLSDNDKWPLSMVLRTFVLQGQSLEGASAGEALAPQQAVQMAVLVIAVVPILCVYPFLQRYFTKGVLTGAIKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JES2</accession>
    <name>A0A2M9JES2_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Arginine--tRNA ligase</fullName>
            <ecNumber evidence="9">6.1.1.19</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Arginyl-tRNA synthetase</fullName>
            <shortName evidence="9">ArgRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">argS</name>
        <name evidence="13" type="ORF">CG723_45140</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">CB01635</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>ATP + L-arginine + tRNA(Arg) = AMP + diphosphate + L-arginyl-tRNA(Arg)</text>
            <dbReference type="Rhea" id="RHEA:20301"/>
            <dbReference type="Rhea" id="RHEA-COMP:9658"/>
            <dbReference type="Rhea" id="RHEA-COMP:9673"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:32682"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78513"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.19"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="9">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9 10">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.19" evidence="9"/>
    <dbReference type="EMBL" id="NNBL01000050">
        <property type="protein sequence ID" value="PJN05395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN05395">
        <property type="protein sequence ID" value="PJN05395"/>
        <property type="gene ID" value="CG723_45140"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004814">
        <property type="term" value="F:arginine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006420">
        <property type="term" value="P:arginyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00671">
        <property type="entry name" value="ArgRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00123">
        <property type="entry name" value="Arg_tRNA_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001278">
        <property type="entry name" value="Arg-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005148">
        <property type="entry name" value="Arg-tRNA-synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036695">
        <property type="entry name" value="Arg-tRNA-synth_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035684">
        <property type="entry name" value="ArgRS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008909">
        <property type="entry name" value="DALR_anticod-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11956">
        <property type="entry name" value="PTHR11956"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03485">
        <property type="entry name" value="Arg_tRNA_synt_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05746">
        <property type="entry name" value="DALR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00750">
        <property type="entry name" value="tRNA-synt_1d"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01038">
        <property type="entry name" value="TRNASYNTHARG"/>
    </dbReference>
    <dbReference type="SMART" id="SM01016">
        <property type="entry name" value="Arg_tRNA_synt_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00836">
        <property type="entry name" value="DALR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="SSF47323"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55190">
        <property type="entry name" value="SSF55190"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00456">
        <property type="entry name" value="argS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9 10" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="6 9 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 9 10" id="KW-0436">Ligase</keyword>
    <keyword evidence="5 9 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 9 10" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Arg_tRNA_synt_N" evidence="12">
        <location>
            <begin position="9"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="domain" description="DALR_1" evidence="11">
        <location>
            <begin position="472"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'HIGH' region" evidence="9">
        <location>
            <begin position="125"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU363038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM01016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PJN05395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="588" mass="64441" checksum="2EDE099C0D71ABEC" modified="2018-04-25" version="1">MASVTSLTASVHQRLADALSAALPEAGAADPLLRRSDRADFQANGILALAKKAKANPRELAATVLDALPANDVIKDVEVSGPGFLNITIADKAIIETLAARAADDRLGVPLQQDAGTTVVDYAQPNVAKEMHVGHLRSAVIGAAMVEILEFTGEKVVRRHHIGDWGTQFGMLIQYLLEHPHELDHEGGKEDGEAAMSSLNRLYKASRALFDSDEEFKARSRDRVVALQAGDAETLALWQRFVDESKIYFYSVFNKLDMQIDDPDVVGESGYNDMLEETCRILEESGVAVRSEGALCVFFDDVLGPDGNKVPLIVKKSNGGYGYAATDLSAIRDRVQNLKASTLLYVVDARQSLHFKMVFETARRAGWLNEDVKAHQLAFGTVLGKDGKPFKTREGETVRLVDLLDEAIDRATAVVREKAEKVGLAEEEIVENGTYVGIGAVKYADLSTSAVRDYKFDLDQMVSLNGDTSVYLQYAYARIRSIFGKAGDRRPVAHPELELAPAERALGLHLDQFGEMLAEVASSYEPHKLAAYLYQLASLYTTFYDQCPVVKPAPAPEVAENRLFLCDLTARTLHQGMALLGIRTPERL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JEU7</accession>
    <name>A0A2M9JEU7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">DNA polymerase III subunit beta</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CG723_44895</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CB01635</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the beta sliding clamp family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000049">
        <property type="protein sequence ID" value="PJN05408.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN05408">
        <property type="protein sequence ID" value="PJN05408"/>
        <property type="gene ID" value="CG723_44895"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009360">
        <property type="term" value="C:DNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008408">
        <property type="term" value="F:3'-5' exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001001">
        <property type="entry name" value="DNA_polIII_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022637">
        <property type="entry name" value="DNA_polIII_beta_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000551">
        <property type="entry name" value="MerR-type_HTH_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30478">
        <property type="entry name" value="PTHR30478"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02767">
        <property type="entry name" value="DNA_pol3_beta_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13411">
        <property type="entry name" value="MerR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00422">
        <property type="entry name" value="HTH_MERR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00480">
        <property type="entry name" value="POL3Bc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="SSF46955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00552">
        <property type="entry name" value="HTH_MERR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50937">
        <property type="entry name" value="HTH_MERR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0235">DNA replication</keyword>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="HTH merR-type" evidence="7">
        <location>
            <begin position="1"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PJN05408.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="361" mass="39159" checksum="0382CB422CF8BDA0" modified="2018-04-25" version="1">MRSIGEMARDSGLSVSALRFYDGAGLLVPAWVDPVSGYRWYAPEQLEESRLLARLRRAGMPLADIRLVLAGWSSADTDLVRKLLQAHLRRLALGLSDARSEFSTLRALLECRENPMTMLRTAIVRLAVSAPELAAALDAVRFAASTDPELPMLGGVLFDIEGEALHVVATDRYRMAVAQAGTTGHGGPRVQVIVPSPLADAMRALLSDDASVQLTVDGDRVALEAGDRQAAGQCLDHDFPDYRRLVRLPAGHRAFIDVRAFREAVETGPVRASEVREQDGVSCDLSVLKVAADGVVTVCEDGDDDQDHVAVNREFLLHALAAAGARDQLILEFGTPTAPLAIRRTDTEDTFSMLMPVRLEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JEZ6</accession>
    <name>A0A2M9JEZ6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Amidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_44630</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000048">
        <property type="protein sequence ID" value="PJN05471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN05471">
        <property type="protein sequence ID" value="PJN05471"/>
        <property type="gene ID" value="CG723_44630"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1300.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000120">
        <property type="entry name" value="Amidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020556">
        <property type="entry name" value="Amidase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023631">
        <property type="entry name" value="Amidase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036928">
        <property type="entry name" value="AS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11895">
        <property type="entry name" value="PTHR11895"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01425">
        <property type="entry name" value="Amidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75304">
        <property type="entry name" value="SSF75304"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00571">
        <property type="entry name" value="AMIDASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidase" evidence="2">
        <location>
            <begin position="27"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="130"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN05471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="499" mass="52103" checksum="48216401FA53AA24" modified="2018-04-25" version="1">MTWDEYREHDAVGLAELVKSGAVSPVEVLEAAIARADAVEPTINAIRHRLDDDARGRARSPLAGPFAGVPFLIKDLGQHLAGVPTGSGNRSLARFPRRETSTVVQRWLDAGLVVFGRTATPEFGARAITEPVAGGPTRNPWDPSRTPGGSSGGSAAAVAAGVVPVAGGNDGGGSIRIPAAACGLFGLKPGRGVVPSGPEVDEVFHGAAVQGVLSRTVRDSAAMLDVLAGSAPEGPYRAAPAERPYADAVVDDPRPLRIGLTTVSPLGGPVDPQVAAAVRDAGELLTGLGHVVEESAPAIDGQRLAADFLTTWFAMVAAEVTAAREFTGCAEDDFEIETRMMAAIGRSLSAPEYLASQSRWHQHTRALAAFHERYDMLLTPTMARPAWPIGEFDLALPVRLAARGLLAARIGGVLGRMNLVEKLAVANLEPAPFTQLANVTGRPASSVPLYRTSSGLPLGVQFVGRPGSEPELLALAAQLERARPWAHLWPSLPDSPSAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JFA8</accession>
    <name>A0A2M9JFA8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Hydroxyacid dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_44070</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000045">
        <property type="protein sequence ID" value="PJN05581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN05581">
        <property type="protein sequence ID" value="PJN05581"/>
        <property type="gene ID" value="CG723_44070"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029753">
        <property type="entry name" value="D-isomer_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006140">
        <property type="entry name" value="D-isomer_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02826">
        <property type="entry name" value="2-Hacid_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00670">
        <property type="entry name" value="D_2_HYDROXYACID_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="2-Hacid_dh_C" evidence="2">
        <location>
            <begin position="121"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN05581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="332" mass="35791" checksum="877034DE820C6259" modified="2018-04-25" version="1">MTSKRRTGLYVMDPARFDDVYGPAERALIERHLTIERPPCAAPELTADLLADIDVLVTGWGAPRLDTALLDQAPRLDLVLYAAGSVRPLVTAESWARGVRVTAAGAVIADRVADFALAQILYALKHGWRYVLTARRTRAAAERRGELGTAGATVGLVSLGATGRATARLLTRHGVRLLAHDPYVSDADIRSLGAEPASLERLFAESDVVSLHAPLLAETRRMVGKRLLRLMRPDATLVNTARGGLIDEPALVTVLKERLDLFAVLDVTDPEPADPGSPLFGLENVVVTPHLAGSLGPERRLLGRAMADDLDRYVAGRPLRHEVVATAMEHAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JG12</accession>
    <name>A0A2M9JG12_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ADP-ribose pyrophosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_42900</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000041">
        <property type="protein sequence ID" value="PJN05782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN05782">
        <property type="protein sequence ID" value="PJN05782"/>
        <property type="gene ID" value="CG723_42900"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="SSF55811"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="1">
        <location>
            <begin position="45"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN05782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="209" mass="23006" checksum="17A02B477244A1DC" modified="2018-04-25" version="1">MTTIKDTAEEWEVRATATPFVGNKTSVRTDDVVMPDGSVVRRDYQVHPGSVAVLALDDHGRVLVLKQYRHPVRHKLWEIPAGLLDIPGENPLHAAQRELYEEAHVKAEDWRVLTDVYTTPGGCSEAVRVFLARDLSEAEGERFEVEDEEADMELARVPLEELVRGVLAGELHNNCLVVGALALTAAQAGGGLESLRPAEAPWPARPFEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-05-25" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JG13</accession>
    <name>A0A2M9JG13_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 12">Phosphoribosylformylglycinamidine cyclo-ligase</fullName>
            <ecNumber evidence="3 12">6.3.3.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10 12">AIR synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11 12">AIRS</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9 12">Phosphoribosyl-aminoimidazole synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="primary">purM</name>
        <name evidence="15" type="ORF">CG723_42535</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">CB01635</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8 12">
            <text>2-formamido-N(1)-(5-O-phospho-beta-D-ribosyl)acetamidine + ATP = 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole + ADP + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:23032"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:137981"/>
            <dbReference type="ChEBI" id="CHEBI:147287"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.3.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 12">Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole from N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide: step 2/2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="12">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the AIR synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.3.1" evidence="3 12"/>
    <dbReference type="EMBL" id="NNBL01000040">
        <property type="protein sequence ID" value="PJN05819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN05819">
        <property type="protein sequence ID" value="PJN05819"/>
        <property type="gene ID" value="CG723_42535"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00129"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004641">
        <property type="term" value="F:phosphoribosylformylglycinamidine cyclo-ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02196">
        <property type="entry name" value="PurM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.650.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00741">
        <property type="entry name" value="AIRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010918">
        <property type="entry name" value="PurM-like_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036676">
        <property type="entry name" value="PurM-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016188">
        <property type="entry name" value="PurM-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036921">
        <property type="entry name" value="PurM-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004733">
        <property type="entry name" value="PurM_cligase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10520">
        <property type="entry name" value="PTHR10520"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00586">
        <property type="entry name" value="AIRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02769">
        <property type="entry name" value="AIRS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55326">
        <property type="entry name" value="SSF55326"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56042">
        <property type="entry name" value="SSF56042"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00878">
        <property type="entry name" value="purM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 12 15" id="KW-0436">Ligase</keyword>
    <keyword evidence="6 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AIRS" evidence="13">
        <location>
            <begin position="64"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="domain" description="AIRS_C" evidence="14">
        <location>
            <begin position="181"/>
            <end position="345"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00020367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00031908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00032931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00033093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF02769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="PJN05819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="357" mass="37338" checksum="0A1DEE736DDF8B82" modified="2018-04-25" version="1">MSETPGASYASAGVDIEAGDRAVELMKEWVKKTQRPEVAGLGGLGGFAGLFDASAFKRYERPLLASATDGVGTKVDIARRLGVYDTIGHDLVAMVMDDIVVCGAEPLFMTDYICVGKVHPERVAAIVKGIAEGCVLAGCSLVGGETAEHPGLLGADDFDVAGAGTGVVEADRLLGPDRIRTGDAVIAMASSGLHSNGYSLVRHVLFDRANLKLDQHIEELGRTLGEELLEPTKIYSLDCLALTRTTDVHAYSHITGGGLAANLARVIPDGLHATVDRSTWAPGAIFDLVGKAGAVERLELEKTLNMGVGMMAIVPQDAVDSALATLADRGVDSWVAGEITERGEHVTGAALTGDYSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JG15</accession>
    <name>A0A2M9JG15_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Amino acid permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CG723_42615</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CB01635</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000040">
        <property type="protein sequence ID" value="PJN05830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN05830">
        <property type="protein sequence ID" value="PJN05830"/>
        <property type="gene ID" value="CG723_42615"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="38"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="69"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="114"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="159"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="188"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="225"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="267"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="319"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="369"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="394"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="435"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="466"/>
            <end position="484"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PJN05830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="514" mass="55170" checksum="50A57D383FA984BD" modified="2018-04-25" version="1">MTSDPAAQQPPPSTDEERLAQLGYTQVLARRMSAFSNYAVSFTIISVLSGCLTMYLFGMNTGGPALITWGWVGVGLMTLFVGLAMAEICSAYPTSAGLYFWAHRLAPARTAAAWAWFTGWFNVLGQVAVTAGIDFGAASFLGAYLNLQFDFEVTPGRTILLFAAILVLHGLLNTFGVRIVGLLNSVSVWWHVVGVAVIVGALAFAPDSHQSASFVFTKFVNNTGWGSGFYVALIGLLMAQYTFTGYDASAHMTEETHDASTAGPKGIVRSIWTSWIAGFVLLLGFTFAIQSYQGALGSATGAPPAQILLDALGATAGKLLLLVVIGAQLFCGMASVTANSRMIYAFSRDGALPFSHVWHTVSPRTRTPVAAVWLAALGALVLGLPYLINVTAYAAVTSIAVIGLYIAYVVPTLLRLRKGDDFERGPWHLGRWSRPIGIVAVVWVAVITVLFMLPQVSPVTWETFNYAPIAVLVVLGFAGVWWLVSARHWFLNPEHARTVAREAGRVGTPEPVDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JGB0</accession>
    <name>A0A2M9JGB0_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HTH tetR-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_42105</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000038">
        <property type="protein sequence ID" value="PJN05925.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN05925">
        <property type="protein sequence ID" value="PJN05925"/>
        <property type="gene ID" value="CG723_42105"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023772">
        <property type="entry name" value="DNA-bd_HTH_TetR-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01081">
        <property type="entry name" value="HTH_TETR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="8"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="31"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN05925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="217" mass="23253" checksum="E99E81BE461CC9D3" modified="2018-04-25" version="1">MVKQERALRTREALIKSAAAAFDGEGFSVSSLTVISRRAGVSNGALHFHFDSKAALAGAVEEAAARRLGLITLRGEGEPGTALQSLVDATHDLARRLRDDEVLRAGFALCGDNAYATSERNLRLQWRKWVEGTLERAEGEGGLAEEVAPHDAVIAVVAATVGFEVLGSQDSTWLSYRTLTQFWQLLLPRLASPSTLGRLRAEGRDDAGAARAAGLRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JGC5</accession>
    <name>A0A2M9JGC5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Phosphopantetheine-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_42180</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000038">
        <property type="protein sequence ID" value="PJN05939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN05939">
        <property type="protein sequence ID" value="PJN05939"/>
        <property type="gene ID" value="CG723_42180"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="SSF47336"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="2">
        <location>
            <begin position="1"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="1">
        <location>
            <position position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN05939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="83" mass="9037" checksum="BA50BA763E1278BE" modified="2018-04-25" version="1">MTDEAIFAVIRAQIVDVLPEVADIEITLDHSMRDLGANSIDRMDVVIAAQDELGIKVPNAELTKANDLRSLVAVFREHASAHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JGI8</accession>
    <name>A0A2M9JGI8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">LLM class F420-dependent oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_41885</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000037">
        <property type="protein sequence ID" value="PJN05999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN05999">
        <property type="protein sequence ID" value="PJN05999"/>
        <property type="gene ID" value="CG723_41885"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.30">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019922">
        <property type="entry name" value="Lucif-like_OxRdatse_MSMEG_4141"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011251">
        <property type="entry name" value="Luciferase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036661">
        <property type="entry name" value="Luciferase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00296">
        <property type="entry name" value="Bac_luciferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51679">
        <property type="entry name" value="SSF51679"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03620">
        <property type="entry name" value="F420_MSMEG_4141"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bac_luciferase" evidence="1">
        <location>
            <begin position="20"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN05999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="295" mass="31894" checksum="7E26BD18EFF54B99" modified="2018-04-25" version="1">MSFSDSSSTQASAIGRYGLWNTGLRDPDPARATELAETAAELEQLGYGALWLGGSSGIEHAAPLIEATSKITVATGILSIWQHEARETADRWAALEAAHPGRFLLGLGVSHAKLTAQYKRPYAAMVDYLDALDTAGIPAGRRVLAALGPRMLELSRDRAAGAHPYLVTPEHTAQAREALGQGPLLAPEFTVVLEADPDRARATARETLALYLQLANYTNSWLRLGFTEDDFANGGSDRLVDALFGWGDEQRVRERIDAFLDAGADHVAIQVLAPGEDRAGLPREQWRRLAATLEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JGL2</accession>
    <name>A0A2M9JGL2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CG723_41170</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000036">
        <property type="protein sequence ID" value="PJN06021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN06021">
        <property type="protein sequence ID" value="PJN06021"/>
        <property type="gene ID" value="CG723_41170"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PJN06021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="102" mass="11182" checksum="19D263AFF58EFA6C" modified="2018-04-25" version="1">MRTLVLGRTPARVTEVLATLRGDGFDAEGVSTDEEARMLLEAEKFGVLIIGGGVEPDSRAAIKELAAEHGVRRVIDGALREPFDTYVRREFEPLIREVTSKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JGY8</accession>
    <name>A0A2M9JGY8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Phosphotransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_40890</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000035">
        <property type="protein sequence ID" value="PJN06146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN06146">
        <property type="protein sequence ID" value="PJN06146"/>
        <property type="gene ID" value="CG723_40890"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="APH" evidence="1">
        <location>
            <begin position="34"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN06146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="281" mass="31175" checksum="68FF841999F61A81" modified="2018-04-25" version="1">MLAACDSAGLPLLPDAELLRLGENALFALPEIGVVARVARSTEMADKVAKELAVARWLAEYGFPSVQPTDTPQPIEANGRLVTFWEYVPESSPPASNTILAALLRGLHDLPDPDFPLPVLDPFPIMRSRLEVVSGIKREDVAFLAEACNNAEEDFRTLIASSPKHLVHGDAHRGNILWDGNRALLIDYEAVAIGPRAWDLVPTVIAVDRFGLPPKDYAEFVRTYGTDVTEWHGYPVLRTTRELGMTTWLMQNAQSGPEADEFALRMESLRKGDLERRWHAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JHD0</accession>
    <name>A0A2M9JHD0_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Glutamate racemase</fullName>
            <ecNumber evidence="2">5.1.1.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CG723_40310</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CB01635</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>L-glutamate = D-glutamate</text>
            <dbReference type="Rhea" id="RHEA:12813"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:29986"/>
            <dbReference type="EC" id="5.1.1.3"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.1.1.3" evidence="2"/>
    <dbReference type="EMBL" id="NNBL01000033">
        <property type="protein sequence ID" value="PJN06286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN06286">
        <property type="protein sequence ID" value="PJN06286"/>
        <property type="gene ID" value="CG723_40310"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008881">
        <property type="term" value="F:glutamate racemase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015942">
        <property type="entry name" value="Asp/Glu/hydantoin_racemase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001920">
        <property type="entry name" value="Asp/Glu_race"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018187">
        <property type="entry name" value="Asp/Glu_racemase_AS_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004391">
        <property type="entry name" value="Glu_race"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21198:SF2">
        <property type="entry name" value="PTHR21198:SF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01177">
        <property type="entry name" value="Asp_Glu_race"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53681">
        <property type="entry name" value="SSF53681"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00923">
        <property type="entry name" value="ASP_GLU_RACEMASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0133">Cell shape</keyword>
    <keyword evidence="6" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="5" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4" id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PJN06286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="257" mass="25800" checksum="3B64F3CF5D7F45C6" modified="2018-04-25" version="1">MDSGIGLIAAAAAVRRLRPDAGLVLSSDPDGMPWGPRSPQGITERALAVAEAAAEHRPDALIVACNTASVHALPALRARLEPGIPVIGTVPAIKPAAAGAGPVAIWATPATTGSPYQRGLIRDFADGVEVTEVPCPGLADAVQHADESAIDRTIAAAAALTPNDVRAVVLGCTHYELVAERIRAAVQQPGMPPLALHGSAGAVATQALRRIGAGPDAGTGAQGALTVLLSGRTSALPPAALAYAEGRLLQAAVSHAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-09-29" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JHJ0</accession>
    <name>A0A2M9JHJ0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="10">RNA helicase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CG723_39415</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000031">
        <property type="protein sequence ID" value="PJN06336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN06336">
        <property type="protein sequence ID" value="PJN06336"/>
        <property type="gene ID" value="CG723_39415"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 10" id="KW-0347">Helicase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Q_MOTIF" evidence="9">
        <location>
            <begin position="70"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="7">
        <location>
            <begin position="101"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="8">
        <location>
            <begin position="295"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="437"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="5">
        <location>
            <begin position="70"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="487"/>
            <end position="511"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PJN06336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="511" mass="54337" checksum="A649E7119E697ABF" modified="2018-04-25" version="1">MNRSARTNDRYSNPRRGSAGGDRGARFRPQGQGQGRTGGKSSGGYGRRSAAPQGEFALPVTVTPALPAVEAFGELDLPAEILKTLTGLGVTVPFPIQAATLPNSLAGRDVLGRGRTGSGKTLAFGLALLARLAGQRAEAKQPFGLILVPTRELAQQVTEALTPYARSLKLRMATVVGGMSIGRQASALRGGAEVVVATPGRLKDLIERKDCRLDRVKITVLDEADQMADMGFMPQVTELLDLVHPEGQRMLFSATLDRNVDLLVRRYLHDPVVHSVDPSAGAVTTMEHHELHVHGADKFAAATEIAARDGRVIMFLDTKHAVDQFTKHLLGSGVRAAALHGGKSQPQRTRTLAQFKAGTVTALVATNVAARGIHVDNLDLVVNVDPPSDHKDYLHRGGRTARAGESGSVVTLVLPNQRRDMSRLMRDAGIRPQITQVRSGEAELSRITGAQAPSGVPIAGPAPATERPKRGGAPFRGMGSRPGRAGGDSRRTSEARQLADARKAARVRRAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JHK6</accession>
    <name>A0A2M9JHK6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Bifunctional D-altronate/D-mannonate dehydratase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_39555</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000031">
        <property type="protein sequence ID" value="PJN06360.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN06360">
        <property type="protein sequence ID" value="PJN06360"/>
        <property type="gene ID" value="CG723_39555"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009063">
        <property type="term" value="P:cellular amino acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034589">
        <property type="entry name" value="D-mannonate_dehydratase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036849">
        <property type="entry name" value="Enolase-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029017">
        <property type="entry name" value="Enolase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029065">
        <property type="entry name" value="Enolase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018110">
        <property type="entry name" value="Mandel_Rmase/mucon_lact_enz_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013342">
        <property type="entry name" value="Mandelate_racemase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034593">
        <property type="entry name" value="Mandelate_racemase_DgoD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013341">
        <property type="entry name" value="Mandelate_racemase_N_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48080">
        <property type="entry name" value="PTHR48080"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48080:SF6">
        <property type="entry name" value="PTHR48080:SF6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13378">
        <property type="entry name" value="MR_MLE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02746">
        <property type="entry name" value="MR_MLE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00033">
        <property type="entry name" value="mannonate_dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00922">
        <property type="entry name" value="MR_MLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51604">
        <property type="entry name" value="SSF51604"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54826">
        <property type="entry name" value="SSF54826"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00908">
        <property type="entry name" value="MR_MLE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00909">
        <property type="entry name" value="MR_MLE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MR_MLE" evidence="1">
        <location>
            <begin position="129"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN06360.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="404" mass="44711" checksum="1D1606273E51A92B" modified="2018-04-25" version="1">MATITSAEVFVTCPGRNYVTLKITTSDGVTGIGDATLNGRELSVASYLRDHVCPTLIGKDPARIEQVWQYLYKGAYWRRGPVTMTAIAAVDVALWDIKGKVAGLPVYQLLGGAARDGVTVYGHASGNTVPELLDDVQRFLAKGFRAVRAQAAVPGLERVYGMRKGDGDTYEPADGALPTEEVWDTGAYLDFVPTYMSAVRERFGYDFHLLHDVHHRLSPIEAGRLGKSLEPYRLFWIEDPTPAEDQEAFRLIRQHTTTPLAVGEIFNSIWDCQHLITNRLIDYIRTSVSHAGGITHLRKIFSLAELYGVRSGSHGAGDLSPASLAAALHVDLSIPNFGMQEYMAHLPGYEAVFQTSWTFEDGLMHPGDRPGIGVEFDEQAAAKFPYERKYLPVNRLRDGSVHDW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JHQ1</accession>
    <name>A0A2M9JHQ1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_39685</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000031">
        <property type="protein sequence ID" value="PJN06382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN06382">
        <property type="protein sequence ID" value="PJN06382"/>
        <property type="gene ID" value="CG723_39685"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007404">
        <property type="entry name" value="YdjM-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04307">
        <property type="entry name" value="YdjM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="32"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="100"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="123"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="150"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="240"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN06382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="264" mass="27737" checksum="E98BD6AB136121C6" modified="2018-04-25" version="1">MMGPAHSLSGAAAWLGVGAAAAAAGHPMPWPVVLVGALICAGAALAPDLDHKAATISRAFGPVSRGLCEIVDKLSYAVYKATRMKGDPRRSGGHRTLTHTWLWAVLIGAGASAAAIFGGRWAVLALLFVHMVLAIEGLLWRAARGSSSDVLVWLLAGTSAWILAGVLDKPGNGSDWLFTQPGQEYLWLGLPIVLGALVHDIGDALTVSGCPVLWPIPIGRKRWYPIGPPKMMRFRAGSWVELKVLMPVFMLLGGVGCAAALNVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JHY3</accession>
    <name>A0A2M9JHY3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CG723_38780</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CB01635</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UPF0126 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000029">
        <property type="protein sequence ID" value="PJN06491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN06491">
        <property type="protein sequence ID" value="PJN06491"/>
        <property type="gene ID" value="CG723_38780"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005115">
        <property type="entry name" value="Gly_transporter"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03458">
        <property type="entry name" value="Gly_transporter"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="38"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="70"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="95"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="120"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="160"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="184"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="domain" description="Gly_transporter" evidence="8">
        <location>
            <begin position="13"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="domain" description="Gly_transporter" evidence="8">
        <location>
            <begin position="99"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF03458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PJN06491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="223" mass="23847" checksum="179BD46038BF8EC1" modified="2018-04-25" version="1">MLLELFTPSVQHWLDLIGIFVFAISGALLAVRKNFDVFGIAVLAEVTALGGGLFRDVIIGAVPPAAFTDLGYFLTPLVAAGLVFFLHPEVERTQVAVNIFDAAGLGLFCVTGTVKAYDYGLGLTASAALGLTTAVGGGVLRDIIANEVPSLVRWDRDLYAVPAIVGSTIIVLCIRFDVLSAFSSGAAVITAFVLRLLAMRYHWRAPRAWHRRSSATEVPEETP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-05-25" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JI99</accession>
    <name>A0A2M9JI99_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 7 8">Transcription elongation factor GreA</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Transcript cleavage factor GreA</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">greA</name>
        <name evidence="11" type="ORF">CG723_38495</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CB01635</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6 7 8">Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7 8">Belongs to the GreA/GreB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000028">
        <property type="protein sequence ID" value="PJN06590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN06590">
        <property type="protein sequence ID" value="PJN06590"/>
        <property type="gene ID" value="CG723_38495"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070063">
        <property type="term" value="F:RNA polymerase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032784">
        <property type="term" value="P:regulation of DNA-templated transcription, elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00105">
        <property type="entry name" value="GreA_GreB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036953">
        <property type="entry name" value="GreA/GreB_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018151">
        <property type="entry name" value="TF_GreA/GreB_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006359">
        <property type="entry name" value="Tscrpt_elong_fac_GreA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028624">
        <property type="entry name" value="Tscrpt_elong_fac_GreA/B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001437">
        <property type="entry name" value="Tscrpt_elong_fac_GreA/B_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023459">
        <property type="entry name" value="Tscrpt_elong_fac_GreA/B_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022691">
        <property type="entry name" value="Tscrpt_elong_fac_GreA/B_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036805">
        <property type="entry name" value="Tscrpt_elong_fac_GreA/B_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30437">
        <property type="entry name" value="PTHR30437"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01272">
        <property type="entry name" value="GreA_GreB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03449">
        <property type="entry name" value="GreA_GreB_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006092">
        <property type="entry name" value="GreA_GreB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46557">
        <property type="entry name" value="SSF46557"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01462">
        <property type="entry name" value="greA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00829">
        <property type="entry name" value="GREAB_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7 8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="11" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="11" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7 8" id="KW-0804">Transcription</keyword>
    <keyword evidence="3 7 8" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="GreA_GreB_N" evidence="10">
        <location>
            <begin position="10"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="domain" description="GreA_GreB" evidence="9">
        <location>
            <begin position="86"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF03449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PJN06590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="165" mass="17766" checksum="3623AD722D9C98D1" modified="2018-04-25" version="1">MTQTSEDVTWLTQEAYTKLKDELEYLSGPARAEITVKIAAAREEGDLRENGGYHAAKEEQGKQELRIRQLTQLLEKAKVGEAPSAAGVAAPGMVVTIAFDGDEDDTMTFLLASREYASADIETYSPQSPLGSGVNGKKIGEDAQYELPNGKLASVKILAAKPYNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JIB9</accession>
    <name>A0A2M9JIB9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CG723_38875</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">CB01635</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000029">
        <property type="protein sequence ID" value="PJN06507.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN06507">
        <property type="protein sequence ID" value="PJN06507"/>
        <property type="gene ID" value="CG723_38875"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011096">
        <property type="entry name" value="FTP_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023612">
        <property type="entry name" value="Peptidase_M4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027268">
        <property type="entry name" value="Peptidase_M4/M1_CTD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001570">
        <property type="entry name" value="Peptidase_M4_C_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013856">
        <property type="entry name" value="Peptidase_M4_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011044">
        <property type="entry name" value="Quino_amine_DH_bsu"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07504">
        <property type="entry name" value="FTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01447">
        <property type="entry name" value="Peptidase_M4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02868">
        <property type="entry name" value="Peptidase_M4_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00730">
        <property type="entry name" value="THERMOLYSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50969">
        <property type="entry name" value="SSF50969"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014915957" evidence="8">
        <location>
            <begin position="23"/>
            <end position="892"/>
        </location>
    </feature>
    <feature type="domain" description="FTP" evidence="11">
        <location>
            <begin position="86"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M4" evidence="9">
        <location>
            <begin position="227"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M4_C" evidence="10">
        <location>
            <begin position="390"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="active site" evidence="7">
        <location>
            <position position="380"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="7">
        <location>
            <position position="472"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR623612-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF07504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PJN06507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="892" mass="93889" checksum="AAD4D273344287B9" modified="2018-04-25" version="1">MLATGVVVAATGSALLAAPAWADDDTTAPPATTAADPVPVAPAMTQGLDGEVRGGTPAEAARAHLKAHKGTYKIPVSDLKTLGTTTSGKQSSVRFRQQHDGVPVFGAEYAVQTEAADGGRRVSSATGTLYTHLTVSTTPTVSQAAAERRMFTLDRDLSRVEGAKTAQHGLTVLPDAAGGKLAWHFTVTGARSDGSPVRQEVYVDARVGGIALSYNNIDAADASPAEGTGVRVDGSEAKLNTNKEADGSYTLVDSTRAMYARTGGQIRTYDAQRKSYTDVAGGPVTDDVPLVKSGSDRFDGANTSSGAVDAHLNAAKVYEFYKDEIGRDGIDGKGGSVYSVVNVASNGRDYANAFWDGDKMVYGHMNGVPLSVGLDVVGHEMTHGVTEHSAGLVYLNQSGALNEAISDYFGNAMETADKGIAMSDPTSGLIGEYLCNGSKPLEECALRDLNDGRSAQKDFEPIPLDIDNGGVHYNSTIVGGALWDIRKNLDPKLADRIVYRSAQNYLTPLSGFTDMRNAVTLAAKSLKVSKADLATIAKAFDAHGIERGWEQKGGTHDATTIAGNVLPAYEVYGGIDEQAAQISGDTYAIGHGDAIAWDRGSAAFGITVGRFGKHAKHELAQKDAYLLDPSLDEHRIVFTRITADGIGIYQAGDKGQGAVRKVVDTPDADETEPVTEKGALAYVSTTADGEQDVMLRKADGTTVNVTPEAGTKASRLAMKNGTIAWVGGDGTYLYVYDIATGKTQNRRMSGWLFGAVTDVQLTSDRVFYRTTTSFLVTTNAVEAAPVSDLAQSKRLKAPSQLYFGQFSVTDDYFVYSSSDAWAGLGGWTGPWKAQVAPTADVLAGTAAYGRISCSSGTQLAPSLGDGQRIAWLDTSAAATDVVTRKTFAGTCE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JIJ6</accession>
    <name>A0A2M9JIJ6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_38480</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000028">
        <property type="protein sequence ID" value="PJN06587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN06587">
        <property type="protein sequence ID" value="PJN06587"/>
        <property type="gene ID" value="CG723_38480"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="24"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN06587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="78" mass="8070" checksum="EB18598858A8A111" modified="2018-04-25" version="1">MSASASLAMTHLVPLAKEVDENKVTPGVLGFIVFAVMALAVWGLMKSMNRHMGKVDFKEKTDAAADPAAGSPASPAKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JIU6</accession>
    <name>A0A2M9JIU6_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Protease HtpX homolog</fullName>
            <ecNumber evidence="12">3.4.24.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">htpX</name>
        <name evidence="14" type="ORF">CG723_37675</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">CB01635</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="12">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="12">Cell membrane</location>
            <topology evidence="12">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the peptidase M48B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.-" evidence="12"/>
    <dbReference type="EMBL" id="NNBL01000026">
        <property type="protein sequence ID" value="PJN06805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN06805">
        <property type="protein sequence ID" value="PJN06805"/>
        <property type="gene ID" value="CG723_37675"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00188">
        <property type="entry name" value="Pept_M48_protease_HtpX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022919">
        <property type="entry name" value="Pept_M48_protease_HtpX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001915">
        <property type="entry name" value="Peptidase_M48"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01435">
        <property type="entry name" value="Peptidase_M48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 12" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 12 14" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="4 12 14" id="KW-0645">Protease</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="8 12" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="33"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="143"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="178"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M48" evidence="13">
        <location>
            <begin position="68"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="active site" evidence="12">
        <location>
            <position position="134"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="133"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="137"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="205"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF01435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="PJN06805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="287" mass="31117" checksum="4D64671D24FBFCF4" modified="2018-04-25" version="1">MHRRHNGLKTAVLLGGLSALIIVIGSFFGRTGLIVGLGIALATNAYAYWNSDKLALRAMRARPVSEFEAPALYRMVRELSTQARQPMPRLYISPTEAPNAFATGRNPRNAAVCCTEGILRILDERELRGVIGHELSHVYNRDILISSVAGALASVIMFLVNFAWLIPIGRSSDDDGPGLLGMLMIMILGPLAATVIQLAISRSREYEADASGAQLTGDPLALASALRKLDAGTKQLPLPPEPRIETASHMMIANPFRPGQGMSKMFSTHPPMAERIARLEQMAGRHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JJP5</accession>
    <name>A0A2M9JJP5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Peptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_35855</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000023">
        <property type="protein sequence ID" value="PJN07105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN07105">
        <property type="protein sequence ID" value="PJN07105"/>
        <property type="gene ID" value="CG723_35855"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.70.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011055">
        <property type="entry name" value="Dup_hybrid_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016047">
        <property type="entry name" value="Peptidase_M23"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01551">
        <property type="entry name" value="Peptidase_M23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51261">
        <property type="entry name" value="SSF51261"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014689681" evidence="1">
        <location>
            <begin position="40"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M23" evidence="2">
        <location>
            <begin position="112"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN07105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="225" mass="22631" checksum="F1EF472E709C612B" modified="2018-04-25" version="1">MSKRTMTLSSGSSLLRTRAAVVTVAMGATALLGAGAAVAAESTQGSVALPGVAAASVQAQAKAQAKAAEQAKQNAATVKKTAAKKAASWMDPVKSYKLSAGFGLGGNMWSHKHSGQDFAVPIGTNVMAAHGGTVVKAGPNGGGDGPAYGNAIVIKHGNGTYSQYAHLSRIDVHIGQTVSTGQHIALSGNTGNSSGPHLHFEIRTTPNYGSAVNPVNFLRSVGVSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JJP9</accession>
    <name>A0A2M9JJP9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_35675</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000023">
        <property type="protein sequence ID" value="PJN07072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN07072">
        <property type="protein sequence ID" value="PJN07072"/>
        <property type="gene ID" value="CG723_35675"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021517">
        <property type="entry name" value="DUF3180"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11377">
        <property type="entry name" value="DUF3180"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="38"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="79"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="121"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN07072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="162" mass="16846" checksum="41DC1CE66F46C16B" modified="2018-04-25" version="1">MKQLRIRTLAGLFLVAGVLSWAGARLWDSIGTLPRVPLAAPIVLAVIAVILLATALSIRARLRAQRERSPGAKGVDPLMAARALVFGQASALVAALVAGMYGGTGAFLLEHLDVPARRDQAIYAGFSVLTGIAVIAAALFLERVCKLPEDDDEDHGGAAPAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JK16</accession>
    <name>A0A2M9JK16_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Multidrug ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CG723_35995</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000023">
        <property type="protein sequence ID" value="PJN07127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN07127">
        <property type="protein sequence ID" value="PJN07127"/>
        <property type="gene ID" value="CG723_35995"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="28"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="60"/>
            <end position="67"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PJN07127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="274" mass="28753" checksum="C153EAD2EC5C5243" modified="2018-04-25" version="1">MMNIPEGSSSPDLSPSPAASPEPPAAAVHAAGLTVVRGPRPVLHALNFAVPRGQITGLLGPSGCGKSTLMRAIVGTQAKVTGTLTVLGHPAGSAELRSRIGYVTQAPSVYADLTVRQNLDYFSAVLQPGRAAASHRRDDVARVIAEVDLTSHADALAGNLSGGQLSRVSLAVALLGTPELLVLDEPTVGLDPVLRRDLWNLFHSIAAERGATLLVSSHVMDEAERCHRLLLMREGEILADDSPDALRAATGADTVEDAFLHLVDQANTLQRSPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JKB8</accession>
    <name>A0A2M9JKB8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_34240</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SorC transcriptional regulatory family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000021">
        <property type="protein sequence ID" value="PJN07315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN07315">
        <property type="protein sequence ID" value="PJN07315"/>
        <property type="gene ID" value="CG723_34240"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007324">
        <property type="entry name" value="Sugar-bd_dom_put"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04198">
        <property type="entry name" value="Sugar-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="SSF100950"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sugar-bind" evidence="2">
        <location>
            <begin position="79"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN07315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="347" mass="36815" checksum="5AE3BA229583D051" modified="2018-04-25" version="1">MNSSEEIAVSALSPGRSAMRMGPAELVQAAAMARRFYLEGKSKIQIAEEFGVSRFKVARVLETALERDLVRIEIRVPAELDAERSDALRARYGLRHAVVVESPAEAEESPDPENLGEVAADLLGELVSEGDVLGLAWGRSTIHMAAALDRLPPCTVVQLTGVYDAGTAERGSVEAVRRAAQVSGGEAHPIYAPMLLPDPATAAALRGQTGIARAFEYFDKVTVACVSIGSWEPGISTVHDMLSDEERAHYASLGVAAEMSAHLFDAEGRRVGRDLGERCITVEADRLRRIPEVVAIAGGQRKAAAIDAVLRSGLVTSLVTDTAAADFLLTAGPTPKPALNRADPDGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JKF4</accession>
    <name>A0A2M9JKF4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Amidohydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_34435</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000021">
        <property type="protein sequence ID" value="PJN07350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN07350">
        <property type="protein sequence ID" value="PJN07350"/>
        <property type="gene ID" value="CG723_34435"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01300">
        <property type="entry name" value="YtcJ_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013108">
        <property type="entry name" value="Amidohydro_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033932">
        <property type="entry name" value="YtcJ-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07969">
        <property type="entry name" value="Amidohydro_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="SSF51338"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydro_3" evidence="1">
        <location>
            <begin position="59"/>
            <end position="540"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN07350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="545" mass="56595" checksum="07657C5DC6B63DCB" modified="2018-04-25" version="1">MSTTPTPPAPAESRTFLLRGGDVHSPADPFATAMVVERGHVAWVGSEGAADAFAEGVDEVVDLEGALVTPAFTDAHVHTTSTGLALTGLDLSAARTRGEALALVRAHAAARPTDRILLGHGWDAARWPDGAPLTRAELDEATGGRPLYLSRIDVHSAAVTTALLDLVPGIADRPGFTPDGPLTRDAHHAVRAAAHAAVTPQQRTEAQRAALRHAASLGIGSVHECGGPDISSEDDFTGLLRLASEESGPRVVGYWADRDIDRARALGAVGAAGDLFVDGALGSHTACLHEPYADAAAGHTGTSYLDAHAVAGHVVACTEAGLQAGFHAIGDAAVTAVVDGVRAAAEKVGLARVRAARHRVEHAEMLSPETIASFAEFGLTASVQPAFDALWGGEDGMYADRLGAERARALNPFAALLRAGVPLAFGSDSPVTPLDPWGTVRAAAFHRTPEHRVSVRAAFTAHTRGGWRAVGRDDAGTLVPGAPADYAVWRTEELVVQAPDDRVARWSTDPRSGTPGLPDLTPGAQLPLCLRTVVGGRTVYVGPDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-09-29" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JKG3</accession>
    <name>A0A2M9JKG3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CG723_34490</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000021">
        <property type="protein sequence ID" value="PJN07361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN07361">
        <property type="protein sequence ID" value="PJN07361"/>
        <property type="gene ID" value="CG723_34490"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="SSF48371"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PJN07361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="472" mass="51128" checksum="38D8F872DDC0389B" modified="2018-04-25" version="1">MFDPVIAPSGTLLGLLQRGRGDGTLHALTAPRAEALAALNHCVLSDPRHDWQVENRSLYYARLYLDLHGELGEIERHLFDPDDVLNTDESRTGLALAVLGHLASYGRRDALELLRRYAAFGSSWAWALDELALRDDDAGLRVLAAPILDRFPEDPEGDAELAAAVRDAYEPRPWRLWADDPREAIGARVRAAQERGSFDQWQRQMRPAGPRPGWSVRAVFDWAQEGLERGAVLYVPAARCLTAVAGPDDRAEIVQAALTGHDGARSTALRYLADNHDPDVLDLIEAAVESPSHAVVDAALDAFERMRTVASLERARRWAPRPDALGAAAGRMLACRGGAQDTEPVLAALREAVRGEGADAPTLWPLVDGAGRLGIASAAPVLRHVYRETASSHLRGHAAKALAATDPSFAAGFAVECLWDCEESTREVAARHAETGDARVVDQLRRLAADPAEEAEVQTAVRSRIGPDATAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-05-25" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JKI5</accession>
    <name>A0A2M9JKI5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">S-(Hydroxymethyl)mycothiol dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CG723_34580</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CB01635</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000021">
        <property type="protein sequence ID" value="PJN07378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN07378">
        <property type="protein sequence ID" value="PJN07378"/>
        <property type="gene ID" value="CG723_34580"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017816">
        <property type="entry name" value="MycoS_dep_FDH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="PKS_ER"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03451">
        <property type="entry name" value="mycoS_dep_FDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="PKS_ER" evidence="3">
        <location>
            <begin position="14"/>
            <end position="361"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PJN07378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="361" mass="37969" checksum="C924DB8C54EB1A04" modified="2018-04-25" version="1">MPHEVRAVVAVKKGAPVEVQTIVVPDPGPGEVLVKVQACGVCHTDLHYREGAINDDFPFLLGHEAAGTIESVGDGVTDLTPGDYVVLAWRAPCGNCRSCRRGRPWYCFDSRNATQPMTLLDGTPLSPALGIGAFAEKTLVAAGQAIKVDPAARPEAAGLIGCGVMAGYGAAVNTGNVQRGDTVAVIGCGGVGNAAIAGACLNGARRVIAVDIDDKKLDQAERFGATHTVNSRGTDPIEAVRALTGGFGVDIAIDAVGRPETYKQAFYMRDHAGVLVQVGVPEPDMAVDIPLIDLFSRGGSLKSSWYGDCLPSRDFPVLIDQYLYGLLDLNAFVTETIALDQVESAFAKMHRGEVLRSVVVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JKP2</accession>
    <name>A0A2M9JKP2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_33545</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000020">
        <property type="protein sequence ID" value="PJN07428.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN07428">
        <property type="protein sequence ID" value="PJN07428"/>
        <property type="gene ID" value="CG723_33545"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041581">
        <property type="entry name" value="Glyoxalase_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18029">
        <property type="entry name" value="Glyoxalase_6"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VOC" evidence="1">
        <location>
            <begin position="8"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="domain" description="VOC" evidence="1">
        <location>
            <begin position="137"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN07428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="263" mass="28732" checksum="7E7F366F48C61618" modified="2018-04-25" version="1">MAARPEGAPVWADAMFPDLEAAKRFYGELLGWTFEEGQEEYGNYTQAKSDGKRVGALSPQMPGMEGTPPAWNLYLATPDVNATAARVKEAGGTLVMEPMEVGDFGTMVTVQDPAGVFFSLWQPGTHDGFEKVGEPGSYAWAEVTTRDTEKTDGFFEAAFPYEVRKMADEDVDFNIWQLDGQPQLGRFKMTEDFPPQVPSYVNVYFAVDDCDAAVATVTRLGGKLHYGPMDTPFGRFAAVTDPQGAAFSVIDLSTTEGEMPDLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JKW4</accession>
    <name>A0A2M9JKW4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_33525</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000020">
        <property type="protein sequence ID" value="PJN07514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN07514">
        <property type="protein sequence ID" value="PJN07514"/>
        <property type="gene ID" value="CG723_33525"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_2-like" evidence="1">
        <location>
            <begin position="7"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN07514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="233" mass="25075" checksum="C7CB6F796021FD96" modified="2018-04-25" version="1">MAPSVDVVLPCLDEAAALPWVLARIPDGWRALVVDNGSTDGSPDIARSLGATVVTEPRRGFGAACHAGLLASDAEVVCFCDCDATLDPALLTTFVEDVIEGRADLVLGRRRPQGRGAFPVHARAGNLALAGMLRRRTGLRLHDLGPLRAARRTSLLGLDLTDRRSGYPLQMVVRAADAGWHIEERPVPYRPRTGKSKVTGTWRGTWQAVRDMRGVLAEKPRTALSARGEAASR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JLI7</accession>
    <name>A0A2M9JLI7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_32195</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000018">
        <property type="protein sequence ID" value="PJN07733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN07733">
        <property type="protein sequence ID" value="PJN07733"/>
        <property type="gene ID" value="CG723_32195"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN07733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="1724" mass="183333" checksum="E4CE41EBF7377AFB" modified="2018-04-25" version="1">MSTAVSGAGAGLGAGSGAAGTTSTAGSVGSVGEAAGERGTMSTGDGTVDTGALLEAGAVLLPGAHRGEDADDLTARAYTHPVLEGRAVVRLVPGTLGDAEDLALDFLGLRRESVRDGLGQVRRETLGFPAWALVNDPDNGHHALALVKDVERLARMAKTRAGAAKDGFEELGERLGRSVPHFLPTYYEEAGRAFLRHENTTYGAALFGKAREAERVHSLDVDEQRQRAVFLEFAFAGALTVKALKDHVRDLTQRLAPQAAWEQYRRLVVERCGAGMPPYAALPQDARKLIRAADLDRVEEECRLLADLLASPAVVRAPGTFWTAYRPTLLVLAAQEPAVRKRLLEIMPTGYGHDNGSEGDWLELLAETGAEQLLTDPAPDAAVDAGDWLSRWSTHLKGGWRGVRRSPMTYDLVERMAARLRAEGRPVDLFRGRGWRSWADLDLIDVCLASGVAVVDPAPRTDGHGIGLDDWFGGPDTGRGDLAAVAADARFRPLLKEAIGGNSHRSVGSRKTIAVAEHPVLRPLLAEWLTEQADAFTAAAGLPGARAALQRLRRFRSVAADVAPGAVARVRAHDLSGNLGRTLRAGIVDELGWPALEEAMELLGPVPEQRHGDGLTVQEAWPALIVAHRDKAVVAGPDGILLEHDLRIPGKPDHWRQPAFRFTGGELLVTWWHEGKQRAYWSSRPADIFHLGGESATQWRAHTLDASLPLPDGGRSTGARPLHAGDTALPKEHRVSGDGVNHWRLRTTSTTSTWIEYDPATGATGRASLPPLLAGAVRDGGRLRHADCQVLPLQAGLENSPLGTDGAVLGRWVRGDGARDGAEERLTAGTPDGREVALPARFTSGRTPVPLGALRLPGGAAPVLALDGNELGLYGDGAGPADGSFGDTVMSRAGAQYAAGTPLVPPTSFWHAMRARDEDGSKALRAFADEQAAALADEAAAALARHRRKTTGEARTALMDEQRQAASDRFDRDLLAATERALPAIGHPSLQAGVGAITLAMVQLRESVAEFTDPQAVAARPVAARRQEMFHDFSPSDGDDRTLLSAIRGVLGHTVFGNWSADTWSTLRQIKSVGHLIAGKAAEGTPLPSGHDLATLSGGWTTDELTIPSCTSTWLRVLQHLPALAYRATVPGLDETDRSALLHLLDAVAEGALTDPGRQLRSVELGEKGAYRPRPGQVLRLGDRTVAILAAARRRGHDDGVDWLALDHDPSGEFKPVAHFTTREAQRIPGTLAGDRIASLAALVRERGATPWHAENATALAAAPGCGPVQAELLLAGRPSGVLADDVGTAECQARSGLTRTQVEAGHDRLTALTWQGRVDVVAALLPETAADLWETGPAVEAAREVWTKRFGALVRFPEDVEISLNGVSTIGNAEAVLNPLHTPWLSRTTVQRLDTDGRLTGDDPTAVPHVRDLVPAVSALGALAYGLPYGHPLRAALPAALDALRTRLADPELLLQLGLDWTEKGDATAPELRKAHGMPETGGAGADGLTRVGEAFVVHPWHQQEAVLLRPAALTGPDDPALGLIEGLTGSRADAPLRAIRAVLGEGLRRAVSAGVPGVDGQVGGPEPDLEGYAQDPTRGVPGLVTEVAETHAIGEDAAALYLQLLALPDPSDRNSTRWTGWKPARMKRARAELAATALVVEAKRARAGRGLFLPGAWLALKAPALPVESWKQALYDIPGNTATVPLLPVPELFTRAWERVRAGDVPAFEELTTRATRKGRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JLM7</accession>
    <name>A0A2M9JLM7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">GTP pyrophosphokinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CG723_31870</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CB01635</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">In eubacteria ppGpp (guanosine 3'-diphosphate 5'-diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + GTP = AMP + guanosine 3'-diphosphate 5'-triphosphate</text>
            <dbReference type="Rhea" id="RHEA:22088"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:142410"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.7.6.5"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Purine metabolism; ppGpp biosynthesis; ppGpp from GTP: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the relA/spoT family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000018">
        <property type="protein sequence ID" value="PJN07677.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN07677">
        <property type="protein sequence ID" value="PJN07677"/>
        <property type="gene ID" value="CG723_31870"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00908">
        <property type="reaction ID" value="UER00884"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015970">
        <property type="term" value="P:guanosine tetraphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00077">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05399">
        <property type="entry name" value="NT_Rel-Spo_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01668">
        <property type="entry name" value="TGS_RSH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002912">
        <property type="entry name" value="ACT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006674">
        <property type="entry name" value="HD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004811">
        <property type="entry name" value="RelA/Spo_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045600">
        <property type="entry name" value="RelA/SpoT_AH_RIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007685">
        <property type="entry name" value="RelA_SpoT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004095">
        <property type="entry name" value="TGS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012676">
        <property type="entry name" value="TGS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033655">
        <property type="entry name" value="TGS_RelA/SpoT"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13291">
        <property type="entry name" value="ACT_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19296">
        <property type="entry name" value="DUF5913"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04607">
        <property type="entry name" value="RelA_SpoT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02824">
        <property type="entry name" value="TGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00471">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00954">
        <property type="entry name" value="RelA_SpoT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="SSF55021"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81271">
        <property type="entry name" value="SSF81271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="SSF81301"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00691">
        <property type="entry name" value="spoT_relA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51671">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51831">
        <property type="entry name" value="HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51880">
        <property type="entry name" value="TGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0418">Kinase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="HD" evidence="6">
        <location>
            <begin position="169"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="domain" description="TGS" evidence="7">
        <location>
            <begin position="521"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="domain" description="ACT" evidence="5">
        <location>
            <begin position="785"/>
            <end position="859"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="688"/>
            <end position="710"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="65"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PJN07677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="863" mass="95398" checksum="0D89346B097E30F8" modified="2018-04-25" version="1">MPDEAKPLSPSAERVGVPTAAKPDQKADQAAAATVVPAKPGKTGQSAAGTPGGKAAEQQPRPKPPADKRPAPGPEAAAPAPAAPPTPPVVRPAAGQPARSGSSNRVRARLARLGVQRSNPYNPVLEPLLRIVRSNDPKIETSTLRQVERAYQVAERWHRGQKRKSGDPYITHPLAVTTILAELGMDPATLMAGLLHDTVEDTEYGLDTLRRDFGDQVALLVDGVTKLDKVKFGEAAQAETVRKMVVAMAKDPRVLVIKLADRLHNMRTMRYLKREKQEKKARETLEIYAPLAHRLGMNTIKWELEDLAFAILYPKMYDEIVRLVAERAPKRDEYLAIVTDEVQSDLRAARIKATVTGRPKHYYSVYQKMIVRGRDFAEIYDLVGIRVLVDTVRDCYAALGTVHARWNPVPGRFKDYIAMPKFNMYQSLHTTVIGPNGKPVELQIRTFDMHRRAEYGIAAHWKYKQEAVAGASKVRSDAPKSTGKDDHLNDMAWLRQLLDWQKETEDPGEFLESLRFDLSRNEVFVFTPKGDVIALPAGATPVDFSYAVHTEVGHRTIGARVNGRLVPLESTLDNGDLVEVFTSKAEGAGPSRDWLGFVKSPRARNKIRAWFSKERRDEAIEQGKDAIVRAMRKQNLPIQRILTGDSLVTLAHEMRYPDISSLYAAIGEGHVTAQSVVQKLVQALGGEEAANEDIAESAPPSRGRSKRRANADPGVVVKGVEDVWVKLARCCTPVPGDPIIGFVTRGSGVSVHRSDCVNVESLSREPERILEVEWAPTQSSVFLVAIQVEALDRSRLLSDVTRVLSDQHVNILSAAVQTSRDRVATSRFTFEMGDPKHLGHVLKAVRGVEGVYDVYRVTSARRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-09-29" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JLV0</accession>
    <name>A0A2M9JLV0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CG723_31080</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CB01635</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000017">
        <property type="protein sequence ID" value="PJN07850.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN07850">
        <property type="protein sequence ID" value="PJN07850"/>
        <property type="gene ID" value="CG723_31080"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="52"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="85"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="173"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="231"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="270"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="301"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="325"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="355"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="387"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="19"/>
            <end position="413"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PJN07850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="439" mass="46549" checksum="12F44780C6CA46E7" modified="2018-04-25" version="1">MTEGKSSRARSAKRVAVAAVAVLFMTWLIDYIDRLVITLALPDIGDEFGLGTTMQGLILTAFFITYALMQIPGGILADTKGARRTMLLAAGGWTIFTAASGLAVGLTSMIAIRAVFGIFQGMYPAASIKALSERTTPEQRLTANGIMSASNPLGSAIAPIVAAPLIVAFGWRGAFWAVSILGLMIVFVLWKGLPKPLTTEELAAASGKKAAPEPVAQVSLRQAMGLLKSSMMWRFTLMFCGFNIIGWGLVSWVPSYLRENKHVSLTGVGLMSGVPWVAAAISMMAGGYLFDRFLQGNHRRVVIPVMLVTAGLLVMMVRAGSATEFIVWETCGTLVMYLAYMQIFGLPLRMLPPEYAGVGGGMVNFGGQLAGAISPFVMGFLAERFSYGVAFSFLGVGCVLAIVGALVTPQTPEAFRAGLGRHLDLSEKKSAPAVAVTAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JM48</accession>
    <name>A0A2M9JM48_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CG723_31065</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000017">
        <property type="protein sequence ID" value="PJN07847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN07847">
        <property type="protein sequence ID" value="PJN07847"/>
        <property type="gene ID" value="CG723_31065"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PJN07847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="126" mass="13842" checksum="DE3FEC91190A0010" modified="2018-04-25" version="1">MGGGLTAECRTFREGIRPQAGGRFAAGEKSAVIANDLRVSVRSVERWRRAWREGGMEALRSAGPANSPAVTDAQFAVLAEELGKGPAAHGFEDERWTLARVQTVIRRQLRLSLSVATVWRLLTRHC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JMB2</accession>
    <name>A0A2M9JMB2_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ADF-H domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CG723_31640</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CB01635</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the actin-binding proteins ADF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000017">
        <property type="protein sequence ID" value="PJN07927.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN07927">
        <property type="protein sequence ID" value="PJN07927"/>
        <property type="gene ID" value="CG723_31640"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015629">
        <property type="term" value="C:actin cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030042">
        <property type="term" value="P:actin filament depolymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002108">
        <property type="entry name" value="ADF-H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029006">
        <property type="entry name" value="ADF-H/Gelsolin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017904">
        <property type="entry name" value="ADF/Cofilin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11913">
        <property type="entry name" value="PTHR11913"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00241">
        <property type="entry name" value="Cofilin_ADF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00102">
        <property type="entry name" value="ADF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51263">
        <property type="entry name" value="ADF_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ADF-H" evidence="3">
        <location>
            <begin position="7"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PJN07927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="139" mass="15556" checksum="C957102B8149BCFF" modified="2018-04-25" version="1">MEGVVVTSAISVEDRCIDAFNELKCNRHITTVLYRLNDSLDTLILDYEGNLTHDELLKSLPSDPRLVAYELCFADRDGSRRAAIVLISWSPQGISSERMAAHAAVYVALRNQLGGIDLFVEAMRQSDLEYNRLVRAARA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JMQ0</accession>
    <name>A0A2M9JMQ0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_29535</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000015">
        <property type="protein sequence ID" value="PJN08150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08150">
        <property type="protein sequence ID" value="PJN08150"/>
        <property type="gene ID" value="CG723_29535"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="28"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN08150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="71" mass="7837" checksum="BF23C6400972D2EB" modified="2018-04-25" version="1">MIWAFVPVLAFLGTPFLPFVNGPYLWFGIPSVLAWCLLWTAGTTASLALVEHFAHTDDERADRDEAEEAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-06-02" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JMV4</accession>
    <name>A0A2M9JMV4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_29815</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000015">
        <property type="protein sequence ID" value="PJN08203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08203">
        <property type="protein sequence ID" value="PJN08203"/>
        <property type="gene ID" value="CG723_29815"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="63"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="64"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN08203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="222" mass="23589" checksum="EB001682A77C290A" modified="2018-04-25" version="1">METTSRVGAQAPAAEGAPEVLTARRTVDGYLLAPFPWYGLDEAFTGSRWLMQVGTSAEGAVEHGAIGHGDEPTVRSEGPAGRDAKERFAVVVTVAASPVRRSADGTGVLEATSVSSAAWLAGVGLLNVTWPGQMDHTLRDDWLDQQTETAWTLADDLESADWTTLSLPVDGVPMPFHYRESEFGWVLAGSTQEGVHLGAYGRGMSAYGLGFSMIKDIGAYEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JN92</accession>
    <name>A0A2M9JN92_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8 17">Aspartokinase</fullName>
            <ecNumber evidence="7 17">2.7.2.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">CG723_28540</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">CB01635</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the phosphorylation of the beta-carboxyl group of aspartic acid with ATP to yield 4-phospho-L-aspartate, which is involved in the branched biosynthetic pathway leading to the biosynthesis of amino acids lysine, threonine, isoleucine and methionine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 17">
            <text>ATP + L-aspartate = 4-phospho-L-aspartate + ADP</text>
            <dbReference type="Rhea" id="RHEA:23776"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57535"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.2.4"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 18">Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; (S)-tetrahydrodipicolinate from L-aspartate: step 1/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4 18">Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; L-homoserine from L-aspartate: step 1/3.</text>
    </comment>
    <comment type="pathway">
        <text evidence="5 18">Amino-acid biosynthesis; L-threonine biosynthesis; L-threonine from L-aspartate: step 1/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6 17">Belongs to the aspartokinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.2.4" evidence="7 17"/>
    <dbReference type="EMBL" id="NNBL01000014">
        <property type="protein sequence ID" value="PJN08338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08338">
        <property type="protein sequence ID" value="PJN08338"/>
        <property type="gene ID" value="CG723_28540"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00034">
        <property type="reaction ID" value="UER00015"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00050">
        <property type="reaction ID" value="UER00461"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00051">
        <property type="reaction ID" value="UER00462"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004072">
        <property type="term" value="F:aspartate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019877">
        <property type="term" value="P:diaminopimelate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009089">
        <property type="term" value="P:lysine biosynthetic process via diaminopimelate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009088">
        <property type="term" value="P:threonine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd04261">
        <property type="entry name" value="AAK_AKii-LysC-BS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1160.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036393">
        <property type="entry name" value="AceGlu_kinase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002912">
        <property type="entry name" value="ACT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041740">
        <property type="entry name" value="AKii-LysC-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001048">
        <property type="entry name" value="Asp/Glu/Uridylate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005260">
        <property type="entry name" value="Asp_kin_monofn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001341">
        <property type="entry name" value="Asp_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018042">
        <property type="entry name" value="Aspartate_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027795">
        <property type="entry name" value="CASTOR_ACT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00696">
        <property type="entry name" value="AA_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01842">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13840">
        <property type="entry name" value="ACT_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000726">
        <property type="entry name" value="Asp_kin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53633">
        <property type="entry name" value="SSF53633"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="SSF55021"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00656">
        <property type="entry name" value="asp_kin_monofn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00657">
        <property type="entry name" value="asp_kinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51671">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00324">
        <property type="entry name" value="ASPARTOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 18" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="13 16" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="14" id="KW-0220">Diaminopimelate biosynthesis</keyword>
    <keyword evidence="12 17 20" id="KW-0418">Kinase</keyword>
    <keyword evidence="15" id="KW-0457">Lysine biosynthesis</keyword>
    <keyword evidence="11 16" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 17" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="ACT" evidence="19">
        <location>
            <begin position="271"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <begin position="7"/>
            <end position="10"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="47"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="74"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <begin position="174"/>
            <end position="175"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="185"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <begin position="210"/>
            <end position="211"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000709"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00005139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00010122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00013059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00016273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR000726-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU003448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="RuleBase" id="RU004249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="PJN08338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="426" mass="45052" checksum="DACEFCA5A8852A23" modified="2018-04-25" version="1">MGLVVQKYGGSSVADAEGIKRVAKRIVDAKKNGNQVVVVVSAMGDTTDELIDLAGQVSPIPAGREFDMLLTAGERISMALLAMAIKNLGHEAQSFTGSQAGVITDSVHNKARIIDVTPGRIRTALDEGNIAIVAGFQGVSQDKKDITTLGRGGSDTTAVALAAALDAEVCEIYTDVDGVFTADPRVVKKARKIDWISFEDMLELASSGSKVLLHRCVEYARRYNIPIHVRSSFSGLQGTWVSNEPHFDQGDQKVEQAIISGVAHDTSEAKITVVGVPDKPGEAANIFRAIADSQVNIDMIVQNVSAASTGLTDISFTLPKTEGRKAIDALEKTKSAVGFESLRYDDQIAKISLVGAGMKTNPGVTAGFFEALSDAGVNIELISTSEIRISVVTRADDVTEAVRAVHTAFGLDSDSDEAVVYGGTGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JNP6</accession>
    <name>A0A2M9JNP6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_29340</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000014">
        <property type="protein sequence ID" value="PJN08475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08475">
        <property type="protein sequence ID" value="PJN08475"/>
        <property type="gene ID" value="CG723_29340"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="SSF46565"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="127"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="222"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN08475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="288" mass="32537" checksum="D577D878D546DAEE" modified="2018-04-25" version="1">MTTPEAESTPSEAPAAEPQAQPVAEGRPEERLERAVLAAEQALIEYEIAVETFRVEVENFSRLHHQKLGPMYTRLDELEAQIAEAVAARSGDPEDRRKADEARARVMPMPAVEELFDQWMDGDGLSPEASAMLTDQPVRPPQRVRPSDEARKLYRELVRKAHPDLAQDEKDRARRDEFIVRVNAAYGRGDEALLRELSDEWAAGPVPEARKPSPSEELYERLEWLAQRKELLTAVAQELEESAIGAMLRMAPDDPDRLLEEIAEQLLAQVAEREAELERLMREQAADS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JNW3</accession>
    <name>A0A2M9JNW3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">RNA polymerase subunit sigma-24</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CG723_27700</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CB01635</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2">Interacts transiently with the RNA polymerase catalytic core formed by RpoA, RpoB, RpoC and RpoZ (2 alpha, 1 beta, 1 beta' and 1 omega subunit) to form the RNA polymerase holoenzyme that can initiate transcription.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000013">
        <property type="protein sequence ID" value="PJN08562.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08562">
        <property type="protein sequence ID" value="PJN08562"/>
        <property type="gene ID" value="CG723_27700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050896">
        <property type="term" value="P:response to stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014303">
        <property type="entry name" value="RNA_pol_sigma-70_ECF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013249">
        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08281">
        <property type="entry name" value="Sigma70_r4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="SSF54427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02957">
        <property type="entry name" value="SigX4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="6">
        <location>
            <begin position="13"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4_2" evidence="7">
        <location>
            <begin position="110"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF08281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PJN08562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="306" mass="33290" checksum="A7916DCA07A9B43E" modified="2018-04-25" version="1">MTDPTAHLGQQAFHEHRKLLFSVAYRLLGTAADAEDVVQDAWIKWSAADRSQVADPRAYLTRIVSNLALERLRSTRHKRETYVGPWLPEPILTGGDASEAVTEAESVSMAMLVVLETLSPLERAVFVLKEVFDFSHAEIAEAVERSEAAVRQAAHRAREHVRARRPRFAADRSRQCEVTERFFAAATGGDINTLMELLSPDVTLWTDGGGKVRQAMRPVVGAATVAAWFAAIGTVAYQGVEPADMKAELVEINGGPGMVFSGLGRVIATVTFDFDANGRITAIHNVANPDKLQAIADGTARDVGTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JP51</accession>
    <name>A0A2M9JP51_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cyclohexanecarboxylate-CoA ligase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_26485</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000012">
        <property type="protein sequence ID" value="PJN08648.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08648">
        <property type="protein sequence ID" value="PJN08648"/>
        <property type="gene ID" value="CG723_26485"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-binding" evidence="1">
        <location>
            <begin position="19"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding_C" evidence="2">
        <location>
            <begin position="426"/>
            <end position="499"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN08648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="526" mass="56800" checksum="B9F3758CD8D40050" modified="2018-04-25" version="1">MNDTAHALGAAGTLWELIERRAALTPDTPVLIQSAPDAKDDRRLTFGELRGRGERVAAGLYDMGVRPGTVVAWQLPTRIETALLSFALARIGAVQSPVIPFYRDREVGFALRESKAEFFATPGVWRGFDHTEMARRLGARGIFEAYDTLPDGDPSVLPPAPTDGTAVRWIYWTSGTTSDPKGVLHTDRSLIAGGSCLAHALHLSASDVGSMAFPFAHIAGPDYTVMLLLYGFPAVMFEQFALPDALDGYRRHGVTVAGGSTAFYSMFLTEQRKSPEDRLIPTLRLLAGGGAPKPPEIYHAVVREMGCQLTHGYGMTEVPMITMGAPDDTAENLATTEGKPPEGMEIRVTDADGKQVPCGVDGEVRLRGEAVCQGYLDPVQSAAAFAGDGFLVTGDLGHVRDTGHLVLTGRAKDIIIRKGENISAKEIEDLLHAHPAVGDAAVVGLPDPERGERVCAVVVQRDGTEPLTLEAMASHLRSEGLSTHKLPEQLELVDALPRNDTLRKVLKYKLRERYSETGPVNAIPER</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JQI2</accession>
    <name>A0A2M9JQI2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Integrase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CG723_24760</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000010">
        <property type="protein sequence ID" value="PJN09128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN09128">
        <property type="protein sequence ID" value="PJN09128"/>
        <property type="gene ID" value="CG723_24760"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.443.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013762">
        <property type="entry name" value="Integrase-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002104">
        <property type="entry name" value="Integrase_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010998">
        <property type="entry name" value="Integrase_recombinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004107">
        <property type="entry name" value="Integrase_SAM-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14659">
        <property type="entry name" value="Phage_int_SAM_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00589">
        <property type="entry name" value="Phage_integrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="SSF56349"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51898">
        <property type="entry name" value="TYR_RECOMBINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyr recombinase" evidence="4">
        <location>
            <begin position="174"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="434"/>
            <end position="465"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PJN09128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="465" mass="53038" checksum="4AEF3BBA83D9387C" modified="2018-04-25" version="1">MSPRKSNLESTIYFGDDGWWHGRVTMGVLPDGSPDRRHRMARTEPAVRRKVRELEKLRDEGRATKAGRKPTVGQWMETYLTDIASLKLKPRSLDDYWSKTRNDIIPGVGKHRIDKLAPEHLEQMYRAMLDAGHAPSHVVKVHRILSRALKIAHRRRMIGENVATLVDPPSIDETETNPFTQEEAKAFLEAAAKRPTFMRWIVGVGMGFRQGETLGLRWPYVDLQAELFHPRWQLQRLTWRHGCGDAHACGARLHRFEPCPPDCATHKGYKRGCPKPCTKTCVKHASICPDRKGGGLAFTRPKTKKSTNPVPIPPSFIPYLIAHKAQQDELREAAGELWQEHQAVFTRPDGRPIDPRDDWEEFKELLAEAGIGDRRLYDGSRHTAGTILNELGVDMPTIMEILRHTQISQTRRYVKGRSHLSKDAMRRMGDAFLPAPQLAPEPATETRTETGDRRAARSRARRRIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JR63</accession>
    <name>A0A2M9JR63_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ABC transporter substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_23915</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000009">
        <property type="protein sequence ID" value="PJN09376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN09376">
        <property type="protein sequence ID" value="PJN09376"/>
        <property type="gene ID" value="CG723_23915"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042597">
        <property type="term" value="C:periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030678">
        <property type="entry name" value="Peptide/Ni-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039424">
        <property type="entry name" value="SBP_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000914">
        <property type="entry name" value="SBP_5_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30290">
        <property type="entry name" value="PTHR30290"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00496">
        <property type="entry name" value="SBP_bac_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002741">
        <property type="entry name" value="MppA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015000076" evidence="1">
        <location>
            <begin position="30"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="domain" description="SBP_bac_5" evidence="2">
        <location>
            <begin position="89"/>
            <end position="456"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN09376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="557" mass="61574" checksum="2C87AEC30EA705C2" modified="2018-04-25" version="1">MTRRPRFTTALIAGLASSSLLLTGCTGTEDTGDSVSSDGMIGHITYAGIGGGSAPQANYNPFLDTSKLVATNFVFESLYQIEQNSCKEVPWLAKSYSWQDPKTLVFTIREGVQWNDGKPMTADDVAFTFNMIKKYDVLDTKAAWPLLKSVKATGDNQVTFSFKKPGASGFTVISSIPVVPEHIWSKVKDPTKFTNAESPVGTGPMKVKSFNPQQVVTERNPRYWQADKVKVKEVRFKANNGSPEIEQLKMGRGEYDTNGMFIPNVKKSYVDKDPKHHHYWYAPGMVMSVYMNLTEAPFSDVGFRRALTSAFDRDTVARKAQLGYVKTASQTGLVLPGQQDWLPEGVKNEGRVPFDPKAADEALTKAGYKKDSQGRRLGKDGKPISFKFKTPTAYTDWVAAAEILVKNLKALGLQVELDRTTPESHDEDRAMGRYDMMFGAHGGDCNMSTGFGHPLGSEGTAPIGKHAFSNEIRWKDKKTDALLTDLRSATKKADQKKAVAGLTEIMMDEVPMIPIWYGAKWFQYDTTRAVGWPNAKNPYAAGGDNLILLTHLRPAKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JRA6</accession>
    <name>A0A2M9JRA6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Baseplate assembly protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_24110</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000009">
        <property type="protein sequence ID" value="PJN09409.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN09409">
        <property type="protein sequence ID" value="PJN09409"/>
        <property type="gene ID" value="CG723_24110"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006531">
        <property type="entry name" value="Gp5/Vgr_OB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037026">
        <property type="entry name" value="Vgr_OB-fold_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04717">
        <property type="entry name" value="Phage_base_V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Phage_base_V" evidence="1">
        <location>
            <begin position="13"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN09409.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="178" mass="18385" checksum="412A03809A4FCCAF" modified="2018-04-25" version="1">MTAQSVKKWHGLYQGVVVSNVDTSDMGRLLVRVPDVLGDDPCIWASPLSPMAGTASGMYVVPLQNSGVWLQFLDGDPNRAVWTGFWRGGAGDVPPAAKSTPPGVPQIVLATPSQNALVISDQSGPAGGSAITLQLHGVGGPFIKMNEMSIEISCGPGRASIVLDGTGVHINGDALTVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JRE3</accession>
    <name>A0A2M9JRE3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">SpdD-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_21950</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000008">
        <property type="protein sequence ID" value="PJN09445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN09445">
        <property type="protein sequence ID" value="PJN09445"/>
        <property type="gene ID" value="CG723_21950"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="59"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="84"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN09445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="110" mass="11152" checksum="180EE638A47CA2CF" modified="2018-04-25" version="1">MFTPKIPVNDQPTGQIIPLNTTPAAVDGHLHAPTDCYCHNQNHAPAASARPTVQLTPGALALLVGGGTAAVLVVGAVLVSMLLAVAITAGSLAIVALVVRSLMNGDAKRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JRG7</accession>
    <name>A0A2M9JRG7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GNAT family N-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_22155</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000008">
        <property type="protein sequence ID" value="PJN09476.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN09476">
        <property type="protein sequence ID" value="PJN09476"/>
        <property type="gene ID" value="CG723_22155"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13302">
        <property type="entry name" value="Acetyltransf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="11"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN09476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="176" mass="19733" checksum="98906CFD5A75A181" modified="2018-04-25" version="1">MDPVILETDRLLLRAFTPADVDAVYEACQDEDIQFYTPVPVPYRRADAEKLVGEKLPAQWAEDKDYTLGAFRKDTGALVGSYCLTLISRGVWELGYWAVKEQRGRGYSVEAAQALCDWGWATLDVHRIEWWAMAGNTGSRAVAENLGFTVEGTLRNRGIANDGKPHDWWVGGLLRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-06-02" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JRM4</accession>
    <name>A0A2M9JRM4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_22540</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000008">
        <property type="protein sequence ID" value="PJN09526.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN09526">
        <property type="protein sequence ID" value="PJN09526"/>
        <property type="gene ID" value="CG723_22540"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN09526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="276" mass="30367" checksum="86EAC3280E6D2A14" modified="2018-04-25" version="1">MSSGRPSTTTPGKTRFDDIYNQPDPRAYFHRLGPLEYEIPHHGQEVFRRARADRAAVHGTDGPVTVLDLCCSYGINAALLNHDLTLAELYEHYTGPEAESLTTAELIEVDKEFYVSRRRPDATPVVGLDAADQAVRYALDVGLLDEGYGENLEQAPPGPGLQRAVGRCGLITVTGGIGYITRSTFEALLECAEVPVWVYAFALRTVLYDPVAAALSAFGLVTETDPAQTYPQRLFTGPAEQRYAIEQVRLAGHDPNGLETAGRYHTQLYRSRPRTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JRX6</accession>
    <name>A0A2M9JRX6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Acetylxylan esterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_22640</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000008">
        <property type="protein sequence ID" value="PJN09635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN09635">
        <property type="protein sequence ID" value="PJN09635"/>
        <property type="gene ID" value="CG723_22640"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008391">
        <property type="entry name" value="AXE1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039069">
        <property type="entry name" value="CE7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40111">
        <property type="entry name" value="PTHR40111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05448">
        <property type="entry name" value="AXE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AXE1" evidence="2">
        <location>
            <begin position="1"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="121"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN09635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="332" mass="35447" checksum="5610357D61FEF87F" modified="2018-04-25" version="1">MPAFDLPLDELQRHRPEPDEPADFDAFWQATLKSATHPEPLIRVRPVDSGLRLVESWDVTFRGFADDPVRAWYTRPAGGGELMPAVVEFAGYGRGRGLPHERLTWANAGYAHLLMDNRGQGDQYGNGGATPDRHAAAPGGPGPAVRGLLDPHDYHYRRLITDAVCAVAALRALPGVDRDRIAAVGNSQGGGVALAVAGLVPDLAAALVTAPLLCGIRRGLDLTDAGPYGEIAAYLAVHRGAEDAAYRTLGYVEGISFARRAHAPAHFGVGLRDQVCPPSGAYAAYHRYGELTGADPAREIHAYPFNGHEHGDAVHVRRQMTWLRGVLGAGGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JS99</accession>
    <name>A0A2M9JS99_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">ATP-dependent zinc metalloprotease FtsH</fullName>
            <ecNumber evidence="5">3.4.24.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">ftsH</name>
        <name evidence="9" type="ORF">CG723_21260</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CB01635</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="5">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homohexamer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
            <orientation evidence="5">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the AAA ATPase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">In the C-terminal section; belongs to the peptidase M41 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">In the central section; belongs to the AAA ATPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.-" evidence="5"/>
    <dbReference type="EMBL" id="NNBL01000007">
        <property type="protein sequence ID" value="PJN09733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN09733">
        <property type="protein sequence ID" value="PJN09733"/>
        <property type="gene ID" value="CG723_21260"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004176">
        <property type="term" value="F:ATP-dependent peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030163">
        <property type="term" value="P:protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.760">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01458">
        <property type="entry name" value="FtsH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005936">
        <property type="entry name" value="FtsH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011546">
        <property type="entry name" value="Pept_M41_FtsH_extracell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000642">
        <property type="entry name" value="Peptidase_M41"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037219">
        <property type="entry name" value="Peptidase_M41-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06480">
        <property type="entry name" value="FtsH_ext"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01434">
        <property type="entry name" value="Peptidase_M41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140990">
        <property type="entry name" value="SSF140990"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01241">
        <property type="entry name" value="FtsH_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="9" id="KW-0132">Cell division</keyword>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 5" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="5 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2 5" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="37"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="148"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="domain" description="AAA" evidence="8">
        <location>
            <begin position="239"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="90"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="649"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="97"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="651"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="470"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="247"/>
            <end position="254"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="469"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="473"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="545"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PJN09733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="672" mass="72500" checksum="E0A8C4D15A201EFE" modified="2018-04-25" version="1">MANPVPPRDRTDQPWRSEGAPPPQPAKPPRKKMPGGWGGLILTALIVYVIANLVLSFFNKGDEPTISYTEFSKQVADNNVTKIYSKGDAIQGQLKKEQPTPGGSDSSSKNYTKFKTQRPSFADDDLWANLEKHNVTVTASPVVQERSFLANLLISLAPMFLLVALWIFISRRMRQGMGGGMAGGMLGRKQPPKPVELEPGTERTTFADVAGIDEVQGELSDVVDFLKNPDAYREMGAKMPRGVLLSGPPGTGKTLLARAVAGEAGVPFFSASASEFIEMIVGVGASRVRELFAEARKVAPSIIFIDEIDTIGRARGGGSAMGGHDEREQTLNQILTEMDGFSGSEGVIVIAATNRADVLDPALTRPGRFDRVVTVSPPDRGGREAILKIHTRQIPLAPDVDLLQVARTTPGMTGADLANLTNEAALLAVKRQQRAVTQTDLSQALEKVQLGAERPLVMPAEERRRTAYHESGHALLGMLQPGADPVRKITIVPRGRALGVTLSTPDADRYAYTEEYLRGRIIGALGGMAAEHVVYGVVTTGAENDLEQVTNIARGMVARWGMSDRIGRLSALPSDAQQAYGLSAAPHTLDTIDHEMRRIVDECYEEACTKLRDHRGQLDALAAALLANETLDEAEAYRVAGVIRLTKDEEAQGTQGIQGTQDTDGQETATDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JSL6</accession>
    <name>A0A2M9JSL6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CG723_21820</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000007">
        <property type="protein sequence ID" value="PJN09832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN09832">
        <property type="protein sequence ID" value="PJN09832"/>
        <property type="gene ID" value="CG723_21820"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018391">
        <property type="entry name" value="PQQ_beta_propeller_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002372">
        <property type="entry name" value="PQQ_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_supfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13360">
        <property type="entry name" value="PQQ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00564">
        <property type="entry name" value="PQQ"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="SSF50998"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PJN09832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="319" mass="34137" checksum="4B8B05DE90F1A678" modified="2018-04-25" version="1">MASPDGPGILPVRDVVVLAAVSGGLTARNVVDGKHRWSAPDIRMSCRYLSLSDRLVAAADWDGILRTFVASTGEPKWTADVDAEVLLAADGDAVYVVTKDRRLRSVGRSDARIRWTVRIPTELGTPIEARGAIARGRLVVATPKGHVIAVATDDGRQVWDLEGQSESMIKPVVDADTVYLHGRELSAFRISDGEKRWSAKSVDEAEYGAEAWGPATVHNGVVYATSGGGSPTGLSSRDGSEAWSTTSVGDVNSPLVVQGSGVWTFCVTDTRTMRLAGGEEEWVYDLPDSLRPAKQKVFAGDGNRVFVSIDGRVCALPVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JT45</accession>
    <name>A0A2M9JT45_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">SAM-dependent methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CG723_20070</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000006">
        <property type="protein sequence ID" value="PJN10018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN10018">
        <property type="protein sequence ID" value="PJN10018"/>
        <property type="gene ID" value="CG723_20070"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PJN10018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="198" mass="21683" checksum="2768ADE8DF6CE042" modified="2018-04-25" version="1">MPFDHNDHYHRPLLRRLPAEGREEGRRALDIGCGTGRFARRLAGRGYQVDALDTSAEVIAEAQAMGGGPRYRRADVTATDLPEGHYDVITCLASLHHMPFATVTRLRAALAPGGALLVLGCYAGRTPRDLVAVPANAAARAAVHVAVRLRGAPRPPLRAPVRRPDMTLTDIRTEAARLLPGSRVRQLLLWRYLLTYNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JT70</accession>
    <name>A0A2M9JT70_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">TetR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_20500</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000006">
        <property type="protein sequence ID" value="PJN10091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN10091">
        <property type="protein sequence ID" value="PJN10091"/>
        <property type="gene ID" value="CG723_20500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="4"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="27"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN10091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="198" mass="21784" checksum="085999E4BB8B27F0" modified="2018-04-25" version="1">MHQKPARVRIVDAAHELMLSIGLARATTKEIAKAADCSEAALYKYFANKEELFVTVLSERLPKLGPLLTELTRKPGAKSVEENLTEIAREAALFYEQTFPMAASLYAEPQLKRRHEEALREMGTGPHRPIQGLDAYLRSEQDAGRVSRDADTYAAASLLLGACAQRAFAYDMAPDRKPPQPLDEFAAGLARTLLTGIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JTL0</accession>
    <name>A0A2M9JTL0_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Histidine kinase</fullName>
            <ecNumber evidence="3">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CG723_17645</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CB01635</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="3"/>
    <dbReference type="EMBL" id="NNBL01000005">
        <property type="protein sequence ID" value="PJN10220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN10220">
        <property type="protein sequence ID" value="PJN10220"/>
        <property type="gene ID" value="CG723_17645"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00672">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00304">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="21"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="162"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="9">
        <location>
            <begin position="186"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="8">
        <location>
            <begin position="252"/>
            <end position="470"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PJN10220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="470" mass="50383" checksum="D013CBE31638196F" modified="2018-04-25" version="1">MSGVRRLGRRWRRQRPLRTRLAVAASAAVALVAVGVCTAAFFVIRYEMFHQLDLNLTQSATRVIQENRDAGPQVVAGECRYLSAPACAQIVPALPAEDPPHTYLLPVSAPVREVATGDRAPYFSNITLSGNPMRMLTTRLGDDKALQVALRSDSVEKGVRQAAGLLTVIGAAGVLLAAGLGYWVSRTGLAPVARLTATAERIASTRDPRHRIELPPGPPGREDEVTRLAASFNTMLGELEQSVTAQRRLVADASHELRTPLTALRTNAELLARADRLTDAQRDRAAGALARQLREVTGLVNDLIELARDEEPTPLLEDVRIAALAEHAVGAARAHWPATPFTLHIAPDAAETVRPGVPARLTRLLTNLLDNAAKFSPEGLPVEVELSSSRRSGSGSGERLELTVRDHGPGITAADLPYVFDRFYRAETARALPGSGLGLAMARQIARAHGAELTAEQAQGGGAVFRLTFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JTY4</accession>
    <name>A0A2M9JTY4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_18305</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000005">
        <property type="protein sequence ID" value="PJN10334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN10334">
        <property type="protein sequence ID" value="PJN10334"/>
        <property type="gene ID" value="CG723_18305"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="149"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="246"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="180"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="246"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN10334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="292" mass="31698" checksum="BBEEA37F99F1EDAB" modified="2018-04-25" version="1">MDADDVAEDLYRLPPVQFMAARNAQVTEAKRAGDTAAARRIAAFRKPTLAAWVSNLLARETEEAGQLLELAEALREAHRTLDPEQFRTLSHQQHVLIAGLARQAGGLARRAGQPVGLSVLHEVEQILHAALADAEVAEQWATGRLTKVPTVSTDFPGTAPLAQVSKKDEKPTPAPASKAPDPAEEKRRARLKEAMKAATEAAAEAGRRDDDVRRAEEEHERATARRSAADERVALLRVQLGEAEEERRIAAEAADEASVRVRDTAREQKAAQRRAASTSRAVERLSGGDSGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JU23</accession>
    <name>A0A2M9JU23_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Enamine deaminase RidA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CG723_18570</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000005">
        <property type="protein sequence ID" value="PJN10374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN10374">
        <property type="protein sequence ID" value="PJN10374"/>
        <property type="gene ID" value="CG723_18570"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035959">
        <property type="entry name" value="RutC-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006175">
        <property type="entry name" value="YjgF/YER057c/UK114"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11803">
        <property type="entry name" value="PTHR11803"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01042">
        <property type="entry name" value="Ribonuc_L-PSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55298">
        <property type="entry name" value="SSF55298"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PJN10374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="136" mass="14142" checksum="9ABA3CFC626B5305" modified="2018-04-25" version="1">MPRAVSLIRSSSLSDVAEYAYAATAPAEARLIFLAGACPLNEDGSTAAVGDYAGQAAKAVENMRTALTESGATLGDVISTRVLVASTRQEDLVTAWEVVRDAFGDHDVPSTLMGVTVLGYHDQLVEIEGVAAVLDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JU60</accession>
    <name>A0A2M9JU60_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Polysaccharide deacetylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_18860</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000005">
        <property type="protein sequence ID" value="PJN10420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN10420">
        <property type="protein sequence ID" value="PJN10420"/>
        <property type="gene ID" value="CG723_18860"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd10938">
        <property type="entry name" value="CE4_HpPgdA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002509">
        <property type="entry name" value="NODB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037950">
        <property type="entry name" value="PgdA-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01522">
        <property type="entry name" value="Polysacc_deac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="SSF88713"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51677">
        <property type="entry name" value="NODB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NodB homology" evidence="1">
        <location>
            <begin position="28"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN10420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="300" mass="34495" checksum="767A1D942D249E12" modified="2018-04-25" version="1">MKDIKIALGVDVDAVAGWLGSYGGEDSPNDIQRGVFAGEIGTPRLLKLFERHGIRTSWFIPGHSIETFPEQTRMIVEAGHEIGAHGYSHENPIAMSPQQEEDVLAKSVELIEQFTGRRPRGYVAPWWEMSESTAALLHKYGFSYDHSQNYRDFTPFYARVGDSWTKIDYSGEAKDWMKPLMHGHEVDLVEFCGNWYVDDLPPMMFNKHSHNSHGYVSPRALEQDWKDQFDWVHRELDYAVIPVTLHPDVSGRPQVLLMLERFIAYVSAHEGVSFCTLEDAADDFRRRFPFESKERPADMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-09-29" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JUH5</accession>
    <name>A0A2M9JUH5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">RNA polymerase subunit sigma</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_15055</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000004">
        <property type="protein sequence ID" value="PJN10541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN10541">
        <property type="protein sequence ID" value="PJN10541"/>
        <property type="gene ID" value="CG723_15055"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1320">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041916">
        <property type="entry name" value="Anti_sigma_zinc_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027383">
        <property type="entry name" value="Znf_put"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13490">
        <property type="entry name" value="zf-HC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="110"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="domain" description="zf-HC2" evidence="2">
        <location>
            <begin position="16"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN10541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="266" mass="28376" checksum="B2CFCD6ED6D83976" modified="2018-04-25" version="1">MSASYDDYGPHGSGDVHETVGAYVLGVLDDAEASAFEAHLAGCELCARQLEEFSGMEPMLAALADLPEPQGTPARERLGAQLGARPSEQLAGRLFDEVAQKRARKRRRGMYLVAAAAALIIGGPLTVLAVNDGGTDNVAEGAHPTSPAEDAFFNHMDEKVKATDAVTKVTATIGMEKKAWGTHTVLELKNVKGPLKCSLIAVGKNGERETVTTWSVPQWGYGIPGSKHEVSKEPLYVHGGAAFERNAIDHFEVETLDGKRLVEVDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JV69</accession>
    <name>A0A2M9JV69_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_16535</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000004">
        <property type="protein sequence ID" value="PJN10785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN10785">
        <property type="protein sequence ID" value="PJN10785"/>
        <property type="gene ID" value="CG723_16535"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="83"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="113"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="173"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN10785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="198" mass="21275" checksum="1448952E5C32678D" modified="2018-04-25" version="1">MSTPLALYARSRGLPLTLLVFLCAALFTLWAGTQQDAFLDPYRRVPLLTLAPLLTSAAIGTSLHQHAEELDRTAVRPWWRRRLAHLLALTGLAAAVLALAVPGDTQVYGAPAMIRNVLGATGITALAAVVIGARLSWLPAMLYFSTVYLSFSSPRMREATVLSWPMQTGPQRGAWAAALLLFALGGALYARRGARAGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JV76</accession>
    <name>A0A2M9JV76_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Alkanal monooxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_15850</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">To bacterial alkanal monooxygenase alpha and beta chains.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000004">
        <property type="protein sequence ID" value="PJN10677.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN10677">
        <property type="protein sequence ID" value="PJN10677"/>
        <property type="gene ID" value="CG723_15850"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011251">
        <property type="entry name" value="Luciferase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036661">
        <property type="entry name" value="Luciferase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019949">
        <property type="entry name" value="Luciferase_OxRdatse_group-1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00296">
        <property type="entry name" value="Bac_luciferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51679">
        <property type="entry name" value="SSF51679"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03558">
        <property type="entry name" value="oxido_grp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bac_luciferase" evidence="2">
        <location>
            <begin position="21"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007789"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN10677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="363" mass="38705" checksum="B1D4BA7E28E17C74" modified="2018-04-25" version="1">MAGNDEIRATAQGAAPVPLSVLDLVTVGAGRTATDALRTSVKIAKLAENRGFNRYWVAEHHSMPGVASSSPAVILAHLAAHTERIRLGSGGVMLPNHAPLVIAEQFGTLEAMAPGRIDLGLGRAPGTDGATAAALRRTDRLNEGADDFPQQLAELTRFLDDDFPDGHPYARIHAVPGPVQATSPGGVQSPHRPPIWLLGSSGFSARLAGVLGLPFAFAHHFSAQNTVPALDLYRESFKPSAVLSSPYALIGVSALAADEEKEARRQVLAAALNMVRLRTGRPGLVPTPEEAERYEFSPMEREFVDSWNSNVIHGTADEVRAGLDDLQKRTGADELMLTANAHTAEIRLRSYELVADAYGLPQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JV97</accession>
    <name>A0A2M9JV97_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 12">Aspartate-semialdehyde dehydrogenase</fullName>
            <shortName evidence="12">ASA dehydrogenase</shortName>
            <shortName evidence="12">ASADH</shortName>
            <ecNumber evidence="7 12">1.2.1.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Aspartate-beta-semialdehyde dehydrogenase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="primary">asd</name>
        <name evidence="14" type="ORF">CG723_16615</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">CB01635</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Catalyzes the NADPH-dependent formation of L-aspartate-semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl-4-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 12">
            <text>L-aspartate 4-semialdehyde + NADP(+) + phosphate = 4-phospho-L-aspartate + H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:24284"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57535"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:537519"/>
            <dbReference type="EC" id="1.2.1.11"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 12">Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; (S)-tetrahydrodipicolinate from L-aspartate: step 2/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 12">Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; L-homoserine from L-aspartate: step 2/3.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4 12">Amino-acid biosynthesis; L-threonine biosynthesis; L-threonine from L-aspartate: step 2/5.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6 12">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5 12">Belongs to the aspartate-semialdehyde dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.11" evidence="7 12"/>
    <dbReference type="EMBL" id="NNBL01000004">
        <property type="protein sequence ID" value="PJN10800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN10800">
        <property type="protein sequence ID" value="PJN10800"/>
        <property type="gene ID" value="CG723_16615"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00034">
        <property type="reaction ID" value="UER00016"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00050">
        <property type="reaction ID" value="UER00463"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00051">
        <property type="reaction ID" value="UER00464"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004073">
        <property type="term" value="F:aspartate-semialdehyde dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071266">
        <property type="term" value="P:'de novo' L-methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019877">
        <property type="term" value="P:diaminopimelate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009097">
        <property type="term" value="P:isoleucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009089">
        <property type="term" value="P:lysine biosynthetic process via diaminopimelate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009088">
        <property type="term" value="P:threonine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02121">
        <property type="entry name" value="ASADH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000319">
        <property type="entry name" value="Asp-semialdehyde_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012080">
        <property type="entry name" value="Asp_semialdehyde_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005986">
        <property type="entry name" value="Asp_semialdehyde_DH_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000534">
        <property type="entry name" value="Semialdehyde_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012280">
        <property type="entry name" value="Semialdhyde_DH_dimer_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01118">
        <property type="entry name" value="Semialdhyde_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02774">
        <property type="entry name" value="Semialdhyde_dhC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00859">
        <property type="entry name" value="Semialdhyde_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01296">
        <property type="entry name" value="asd_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01103">
        <property type="entry name" value="ASD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="9 12" id="KW-0220">Diaminopimelate biosynthesis</keyword>
    <keyword evidence="10 12" id="KW-0457">Lysine biosynthesis</keyword>
    <keyword evidence="11 12" id="KW-0486">Methionine biosynthesis</keyword>
    <keyword evidence="12" id="KW-0521">NADP</keyword>
    <keyword evidence="12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 12" id="KW-0791">Threonine biosynthesis</keyword>
    <feature type="domain" description="Semialdhyde_dh" evidence="13">
        <location>
            <begin position="2"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-thioester intermediate" evidence="12">
        <location>
            <position position="123"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="12">
        <location>
            <position position="249"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="9"/>
            <end position="12"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="37"/>
            <end position="38"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="93"/>
        </location>
        <ligand>
            <name>phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="150"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="153"/>
            <end position="154"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="242"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="316"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00010584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00013120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="PJN10800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="338" mass="35364" checksum="C4E5BFC859547287" modified="2018-04-25" version="1">MKVGIVGATGQVGTVVRKILVERDFPVDELRLFASARSAGTVIDGVTVEDASTADYTGLDIVIFSAGGSTSKALAEKVAAQGAVVIDNSSAWRKDPEVPLVVSEVNPHAIANRPKGIIANPNCTTMAAMPVLRPLHEEAGLEALVVATYQAVSGSGLAGVAELHGQAQKVVAEADKLTHDGSAVEFPEPQVYKRPIAFNVLPLAGAIVDDGLNETDEEQKLRNESRKILEIPGLKVSGTCVRVPVFSGHSLQINARFARPLSVERATELLSGAPGVELSDIPTPLQAAGQDASYVGRIRGDETVENGLSLFVSNDNLRKGAALNAVQIAELVAAELKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JVD3</accession>
    <name>A0A2M9JVD3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CG723_16725</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000004">
        <property type="protein sequence ID" value="PJN10819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN10819">
        <property type="protein sequence ID" value="PJN10819"/>
        <property type="gene ID" value="CG723_16725"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03255">
        <property type="entry name" value="ABC_MJ0796_LolCDE_FtsE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017911">
        <property type="entry name" value="MacB_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="19"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="55"/>
            <end position="62"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PJN10819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="264" mass="27846" checksum="9521B35F0E3A62A9" modified="2018-04-25" version="1">MGLGTKRHDEAPRDDRWAVDLRGVRRQYGRGSGAVHALRGIDLALPRGSFTAVMGPSGSGKSTFLQCAAGLDRPTDGTVRLGGTLITGMSENKLTALRRTRLGFVFQAFNLLPSLTVEQNVVLPMRLAGRRPDRRRAAEVLAQVGLGDKGKRRPGQLSGGQQQRVAIARALITRPDVVFADEPTGALDTTTAADILGLLRTAVDSMGATVVMVTHDPAAAACADRVLFLADGRIVDQLHGACAQAIAARMTTLTAPAYAGAAAW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JVI0</accession>
    <name>A0A2M9JVI0_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 6">Beta-glucosidase</fullName>
            <ecNumber evidence="2 6">3.2.1.21</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CG723_17175</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CB01635</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>Hydrolysis of terminal, non-reducing beta-D-glucosyl residues with release of beta-D-glucose.</text>
            <dbReference type="EC" id="3.2.1.21"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the glycosyl hydrolase 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.21" evidence="2 6"/>
    <dbReference type="EMBL" id="NNBL01000004">
        <property type="protein sequence ID" value="PJN10895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN10895">
        <property type="protein sequence ID" value="PJN10895"/>
        <property type="gene ID" value="CG723_17175"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008422">
        <property type="term" value="F:beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102483">
        <property type="term" value="F:scopolin beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030245">
        <property type="term" value="P:cellulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001360">
        <property type="entry name" value="Glyco_hydro_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017736">
        <property type="entry name" value="Glyco_hydro_1_beta-glucosidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033132">
        <property type="entry name" value="Glyco_hydro_1_N_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10353">
        <property type="entry name" value="PTHR10353"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00232">
        <property type="entry name" value="Glyco_hydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00131">
        <property type="entry name" value="GLHYDRLASE1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03356">
        <property type="entry name" value="BGL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00653">
        <property type="entry name" value="GLYCOSYL_HYDROL_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="5">
        <location>
            <begin position="407"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="4">
        <location>
            <position position="165"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="4">
        <location>
            <position position="360"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="28"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="120"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="164"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="288"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="400"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR617736-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR617736-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PJN10895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="446" mass="48953" checksum="8E257E45AC42A18B" modified="2018-04-25" version="1">MIARMAASEPIPQFPHDFLWGVSTSAHQIEGAVDARLPSVWDAFAAEPGRVKDGSTAAVACDHYHRYGEDVALIAGLGAGAYRFSVSWPRVLSPGGLDFYDRLVDALCAAGVQPVPTLFHWDTPLSVEEAGGWLRRDTASLFADYAVRVADRIGDRVQKWITLNEPAEHTLLGHALGQHAPGRQLLFDALPAAHHQLLAHGLAVRALRAAGATDIGIANSHGPTWPASDDPADREAADFYDVLLNRLFADPLLLGAYPEGIGDLMPGDVDADLKVIAEPVDWYGINFYQPTKVGAPLTSGDATEFSGLTLPPELPFSPREIEGYPVTDFGWPVVPEALTELLLAFRDRYGDRLPPLVITENGCSYEGVDDQERIAYLDGHLRALHRALEAGVDVRGYFVWSLMDNFEWAEGYARRFGLVHVDYATLERTPKASYHWLRDVLRAQRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JVI9</accession>
    <name>A0A2M9JVI9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CG723_17235</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CB01635</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000004">
        <property type="protein sequence ID" value="PJN10903.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN10903">
        <property type="protein sequence ID" value="PJN10903"/>
        <property type="gene ID" value="CG723_17235"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045621">
        <property type="entry name" value="BPD_transp_1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19300">
        <property type="entry name" value="BPD_transp_1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="105"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="138"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="180"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="247"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="285"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="99"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PJN10903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="320" mass="34335" checksum="B9103E5F0A12C608" modified="2018-04-25" version="1">MVVIARILARRLVLLVPLLLGIVLFVFLVMRFSDSDPASAFFQGANPTPQQLHDFRERNGLLDPLPVRYFHFVGDLVRGDMGVSALTRQPVVDQVTTALPLTLQLTFLGLAVAVVVSLVLGVTAAIHRDRLLDQVIRVVSLTGVAAPGFWLALLMIQYLAVGQGWFPTGGYINPADSFSGWLKCMTLPALSLSLPVAAQLTRIVRTAVVEELDKDYVRTAIGSGLPPVVVVGRNVLRNALINPLTVLGLRVGYLLGGAVVTETIFSLPGMGKLMIDAVKNGDPAVVQGVVLTTAVGFVVVNLAIDILYLMVNPRLRGAQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JVV3</accession>
    <name>A0A2M9JVV3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CG723_08600</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN11035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN11035">
        <property type="protein sequence ID" value="PJN11035"/>
        <property type="gene ID" value="CG723_08600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PJN11035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="99" mass="11050" checksum="B4B3572536EF35D6" modified="2018-04-25" version="1">MTTRHTDHTTEKTVRQQVLVLYLGTSALDSEVVGWACYDGTGRTHPTTGDSDEPPYMTGVAALEDGWRLFQAAQLIPAPPGSEYETSFLKHEFFFEKLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JW45</accession>
    <name>A0A2M9JW45_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">MHYT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_08920</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN11084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN11084">
        <property type="protein sequence ID" value="PJN11084"/>
        <property type="gene ID" value="CG723_08920"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005330">
        <property type="entry name" value="MHYT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03707">
        <property type="entry name" value="MHYT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50924">
        <property type="entry name" value="MHYT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="15"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="45"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="82"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="111"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="145"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="172"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="211"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="domain" description="MHYT" evidence="2">
        <location>
            <begin position="9"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN11084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="260" mass="26283" checksum="1AA2B519B98BA3D8" modified="2018-04-25" version="1">MGHMHHMAGGWATPVLSYAMAVVGSALGLRCTVRALTAEGRSKRNWLVSASIAIGAGIWTMHFIAMLGYAVDGTAIRYDIPLTLLSLLVAIAVVGAGVFTAGYGKSRVRSILFGGVGTGLGVAAMHYIGMAAVELNGTISYSPAVVSASVVIAIAAASAALWAALSVRGPAVAAVAALVMGLAVSSMHYTGMAAVTVDVHASNAPLPGASATAFILPLAVVLGSFLFLTCAFVALSPTARERAEGEAAARPLHEVELPVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JW47</accession>
    <name>A0A2M9JW47_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">AraC family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_08155</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN10977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN10977">
        <property type="protein sequence ID" value="PJN10977"/>
        <property type="gene ID" value="CG723_08155"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002818">
        <property type="entry name" value="DJ-1/PfpI"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01965">
        <property type="entry name" value="DJ-1_PfpI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DJ-1_PfpI" evidence="1">
        <location>
            <begin position="2"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN10977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="203" mass="21786" checksum="BBF4D241BB65CC87" modified="2018-04-25" version="1">MHVAILTFDGYNELDSLIALGVLNRIKSDDWRVTIATPSLKVTSMNGVVIEQMSTLEEACAADAVIVGSGIATREVVEDPAIMNVLRRLDPSRQLIAAQCSGALVLAKLGLLNDIPTCTDLTTKPWVVAAGVEVLNQPFYAKDNIATAGGCLASHYLAAWIIARLEGNDAAEGALHYVAPVGEKEEYIERAWRNITPYLPAPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JWA1</accession>
    <name>A0A2M9JWA1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_09480</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN11171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN11171">
        <property type="protein sequence ID" value="PJN11171"/>
        <property type="gene ID" value="CG723_09480"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004061">
        <property type="term" value="F:arylformamidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019441">
        <property type="term" value="P:tryptophan catabolic process to kynurenine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007325">
        <property type="entry name" value="KFase/CYL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037175">
        <property type="entry name" value="KFase_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04199">
        <property type="entry name" value="Cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102198">
        <property type="entry name" value="SSF102198"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN11171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="325" mass="35484" checksum="AB60E249A86BF6B4" modified="2018-04-25" version="1">MPLPPQTHEDLLHRTDAPPGSSWHLFADQPERGMANFAGPPQIRRATQCVRDGRALNLDYPLDAFDPPMAQARGIPHHHITAKHDEARDDVLDNFHLQASTQIDGLRHRRASGHGFYNGVPDHEIAPRSPRLGVQLWAETPLAGRGLLIDIEGLFRERGTPLDHATGPALTAALLDEALDAQGCTVEDGDLVLVHTGWAHWYLTTDPATRAETRAARRATGFAQSRAFAAWCWDHRIALMATDTFAVEVLPVLPESDYLESAPEDAGMMHQELIAKLGLPLGELWNLTGLAADCRATGRWDSLLTVKPLHLTGGVGSPANATALR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-05-25" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JWN7</accession>
    <name>A0A2M9JWN7_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA-(apurinic or apyrimidinic site) lyase</fullName>
            <ecNumber evidence="3">4.2.99.18</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">CG723_10280</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">CB01635</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FPG family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.99.18" evidence="3"/>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN11310.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN11310">
        <property type="protein sequence ID" value="PJN11310"/>
        <property type="gene ID" value="CG723_10280"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140078">
        <property type="term" value="F:class I DNA-(apurinic or apyrimidinic site) endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019104">
        <property type="term" value="F:DNA N-glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006284">
        <property type="term" value="P:base-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.190.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015886">
        <property type="entry name" value="DNA_glyclase/AP_lyase_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012319">
        <property type="entry name" value="FPG_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035937">
        <property type="entry name" value="MutM-like_N-ter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010979">
        <property type="entry name" value="Ribosomal_S13-like_H2TH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000214">
        <property type="entry name" value="Znf_DNA_glyclase/AP_lyase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010663">
        <property type="entry name" value="Znf_FPG/IleRS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01149">
        <property type="entry name" value="Fapy_DNA_glyco"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06831">
        <property type="entry name" value="H2TH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06827">
        <property type="entry name" value="zf-FPG_IleRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00898">
        <property type="entry name" value="Fapy_DNA_glyco"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01232">
        <property type="entry name" value="H2TH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46946">
        <property type="entry name" value="SSF46946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81624">
        <property type="entry name" value="SSF81624"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51068">
        <property type="entry name" value="FPG_CAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51066">
        <property type="entry name" value="ZF_FPG_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0227">DNA damage</keyword>
    <keyword evidence="10" id="KW-0234">DNA repair</keyword>
    <keyword evidence="9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="17" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="13" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="17" id="KW-0540">Nuclease</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 14" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="FPG_CAT" evidence="16">
        <location>
            <begin position="2"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="domain" description="FPG-type" evidence="15">
        <location>
            <begin position="237"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012720"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="PJN11310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="286" mass="30764" checksum="A7368BBCD30EB142" modified="2018-04-25" version="1">MPELPEVEALTDFLTEHLVGHEIVRVLPVAVSVLKTYDPPPAALEGRTVTGVTRHGKFLDLDADGLHLVTHLARAGWLHWKDRLPDGPPRPGKGPLALRVALEDGEGFDLTEAGTQKSLAVYVVHDPADVPGIARLGPDPLADGFDEARLAALLDGERRQIKGALRDQSLIAGIGNAYSDEILHAAKMSPFKLASSLTADDVSVLYKALRDTLTEAVERSRGVAAGRLKAEKKSGLRVHGKAGEKCPVCGDTIREVSFHDSSLQYCPTCQTGGKPLADRRMSKLLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JWP9</accession>
    <name>A0A2M9JWP9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Class F sortase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_10335</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN11321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN11321">
        <property type="protein sequence ID" value="PJN11321"/>
        <property type="gene ID" value="CG723_10335"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05829">
        <property type="entry name" value="Sortase_F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005754">
        <property type="entry name" value="Sortase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023365">
        <property type="entry name" value="Sortase_dom-sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042001">
        <property type="entry name" value="Sortase_F"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04203">
        <property type="entry name" value="Sortase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63817">
        <property type="entry name" value="SSF63817"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="43"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN11321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="218" mass="22773" checksum="712340D246697840" modified="2018-04-25" version="1">MSSSQPADEEGQQKKRAPWGVMALVLLTGLALIRNGSGEFDIGPPQPASAAAADPRSPSGAAAPKPLPFSVADRVQIPAIQVDAPVMPVGVAADGWVDAPPPEDPNLAGWFTGGVTPGEKGTAVIVGHVDNQQGPAVFYGLGSLKKGNHVQVMRKDRKTAVFEIYGIEVFSKANFPGKRVYGSTGVPELRVITCGGGFSKQNGYDGNVVVFARLIEVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JWR8</accession>
    <name>A0A2M9JWR8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CG723_10415</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN11335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN11335">
        <property type="protein sequence ID" value="PJN11335"/>
        <property type="gene ID" value="CG723_10415"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PJN11335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="166" mass="18978" checksum="0ED555F17E0C4304" modified="2018-04-25" version="1">MIDNSRPLARPLAVFDLDNTLADTAHRQRFLERTPRDWSAFFGAAPEDPPLARGVELALESARECEVVYLTGRPERCRADTVAWLAEQGLPEGRVWMRRNDDRRPARRTKLETLRTLSRGREVRMLVDDDELVCDEAERAGFTVVRARWASGSEALKDAQEREGRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JWS2</accession>
    <name>A0A2M9JWS2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Benzaldehyde dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CG723_10470</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CB01635</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN11345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN11345">
        <property type="protein sequence ID" value="PJN11345"/>
        <property type="gene ID" value="CG723_10470"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016620">
        <property type="term" value="F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="SSF53720"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00687">
        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldedh" evidence="5">
        <location>
            <begin position="17"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PJN11345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="478" mass="49484" checksum="3DB671CD9671C4A8" modified="2018-04-25" version="1">MPLLDPKTWQARPLSGDEHEVTEPATGERLATVTLASPDDVRTAAKAAAAAQGDWARQPHFARAAVLRRAGDLFTEHADELRTWLVRESGSIPGKADFELHVAAQECYEAAALASRPAGHVLPSEAPRLSYTRRVPAGVVGVIAPFNAPLILSIRSVAPALALGNAVVLKPDPRTAVCGGLALAAVLAAAGLPEDVLHVLPGGADAGQALVTDPDVPVISFTGSTGAGRAVGEAAGRHLKRAHLELGGNSALIVLADADLDAVISTAAWGSFFHQGQICMTTGRHLVHASLYEEYVERLAAKADSLAVGDPHREQVHLGPVIDAAQLAKIHGLVEASTAAGAKLAAGGKHRDLFYRPTVLAGVDDSTPAYAEEVFGPVAPVRSFTDADEAAALAAASPYGLSLGIVTRDPARGLDLAERIPTGIVHINDQTVNDEAVAPFGGVAASGTGARFGGEANIEAFTETRWTTVRGDVAGYPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JWZ3</accession>
    <name>A0A2M9JWZ3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CG723_10885</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CB01635</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mo-bis(molybdopterin guanine dinucleotide)</name>
            <dbReference type="ChEBI" id="CHEBI:60539"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the prokaryotic molybdopterin-containing oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN11415.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN11415">
        <property type="protein sequence ID" value="PJN11415"/>
        <property type="gene ID" value="CG723_10885"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008863">
        <property type="term" value="F:formate dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030151">
        <property type="term" value="F:molybdenum ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043546">
        <property type="term" value="F:molybdopterin cofactor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02787">
        <property type="entry name" value="MopB_CT_ydeP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02767">
        <property type="entry name" value="MopB_ydeP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009010">
        <property type="entry name" value="Asp_de-COase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037951">
        <property type="entry name" value="MopB_CT_YdeP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006657">
        <property type="entry name" value="MoPterin_dinucl-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006656">
        <property type="entry name" value="Mopterin_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010046">
        <property type="entry name" value="Mopterin_OxRdtse_a_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041953">
        <property type="entry name" value="YdeP_MopB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43105:SF4">
        <property type="entry name" value="PTHR43105:SF4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00384">
        <property type="entry name" value="Molybdopterin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01568">
        <property type="entry name" value="Molydop_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50692">
        <property type="entry name" value="SSF50692"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01701">
        <property type="entry name" value="Fdhalpha-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Molybdopterin" evidence="5">
        <location>
            <begin position="119"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="domain" description="Molydop_binding" evidence="6">
        <location>
            <begin position="646"/>
            <end position="753"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PJN11415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="764" mass="84243" checksum="AB843379AFE9D335" modified="2018-04-25" version="1">MSSSIEDPIDDLTVTPPKTWATGLPAVTHALEYSLGQTSPRRTMLTLLNINQAKGIDCPGCAWPEPAPGKRHMNEYCENGAKHINDEATSRRVTRDFFREHSIAELDSKSDYWLNQQGRLTEPMVKRPGATHYEPIGWDEAFGILAKELKQLTSPDEALFYVSGRLNNEAAFLLQLFARAYGTNNLPDCSNMCHESSGSAMSETLGIGKGTVSLDDLENSDLVFVVGQNPGTNHPRMLSSLEETKRNGGKIVAVNTLPEAGLLRFKHPQRPRGIIGKGTQIADQFLHIRAGGDLALFQALNLLLLEAEDANPGTVIDHAFIEKNTIGYEAFEKHAREVTWEHIYDATGLSREEIDEVFERVLNAKSVIVCWAMGLTQHKHGVPSIREVINFLMLRGNIGKPGAGACPVRGHSNVQGDRTMGVWERMPQKFLDSLGKEFGFTPPTHHGLDAVDGIRAMYEKRARFFLGVAGNFVRATPDSEVTEQAMRNCSLTAHVSTKLNRSHTVCGETALILPTLGRSDKDFQATGEQFITVEDSMSDVHASRGKLPPASPDLLSEVAIVSRMALATIGDKYGIPWQGFEDDYGTVRDRISHVIPGFEDFNERVSKPGGFNLPNPANHGVFNTPSGKAVFTQNEFTMPHVPEGHLLLQTLRSHDQWNTIWYAPNDRYRGIHNARRVVMVNPADLELLGIEDGDMVDLVSVWHDERERRAENFKVVAYPASPGSAAAYYPETNVLVPLDSVADISNCPTSKGVVVRLEPVGTPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JX81</accession>
    <name>A0A2M9JX81_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NAD-dependent dehydratase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_11305</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN11483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN11483">
        <property type="protein sequence ID" value="PJN11483"/>
        <property type="gene ID" value="CG723_11305"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Epimerase" evidence="1">
        <location>
            <begin position="3"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN11483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="341" mass="36469" checksum="230A1550DB924456" modified="2018-04-25" version="1">MRVLLTGHQGYLGTVMAPVLTAAGHDVVGLDAGLFADCVLGPPPADPAGHRVDLRDVTADHVAGVDAVIHLAALSNDPLGSLAPDLTYDINHHASVRLARLARDAGVRRFLYASTCSVYGAAGGDDLVGEDAPLRPVTPYAESKVRVEDDLHALADGDFSPVFMRNATAFGYSPRLRADIVLNNLVGHALLSGEVLVMSDGTPWRPLVHAADIAHAFTAALTAPRETVHDRAFNIGSEINNVTVAEIAEQVAEAVSGSKVVITGETGADPRSYRVDFSRFRAAIPGFDCAWTVKQGALELADAYRKFGLTREDFERRFTRLAVLRAASEAGAVDDTLRWRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JXI3</accession>
    <name>A0A2M9JXI3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_11950</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN11594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN11594">
        <property type="protein sequence ID" value="PJN11594"/>
        <property type="gene ID" value="CG723_11950"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.850">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000868">
        <property type="entry name" value="Isochorismatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036380">
        <property type="entry name" value="Isochorismatase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00857">
        <property type="entry name" value="Isochorismatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52499">
        <property type="entry name" value="SSF52499"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Isochorismatase" evidence="1">
        <location>
            <begin position="10"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN11594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="194" mass="20773" checksum="C34B46F8E108F4CE" modified="2018-04-25" version="1">MALTTLDERTALVVVDLQNGIVGTPTTPYSGPEVVARSVELADAFRAHGLPVVLVRVSAAPDGADAVPGRNETQGRTGARPEGWDVIVDELSGHPEDITVTKRNWGAFFGTDLDLQLRRRGITQVVLTGVATSIGVESTARAAHEHGYHVTLATDAMTDLDVEAHRNSIERIFPRLGETGTSEEITELLAKTRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-05-25" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JXL0</accession>
    <name>A0A2M9JXL0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">S-(Hydroxymethyl)mycothiol dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CG723_11435</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CB01635</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN11507.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN11507">
        <property type="protein sequence ID" value="PJN11507"/>
        <property type="gene ID" value="CG723_11435"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017816">
        <property type="entry name" value="MycoS_dep_FDH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="PKS_ER"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03451">
        <property type="entry name" value="mycoS_dep_FDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="PKS_ER" evidence="3">
        <location>
            <begin position="14"/>
            <end position="359"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PJN11507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="361" mass="37759" checksum="708132BA6A22D1D5" modified="2018-04-25" version="1">MAQQVRGVIARAKGEPVRIETIVVPDPGPGEAVVKIQACGVCHTDLHYREGGINDEFPFLLGHEAAGVVEAVGDGVTEVAPGDFVILNWRAVCGQCRACLRGRPQYCFDTHNAKQKMTLLDGTELSPALGIGAFADKTLVAAGQCTKVDPEASPAAAGLLGCGVMAGLGAAINTGNVGRGDSVAVIGCGGVGAAAVTGAHLAGAGKIIAIDIDDKKLATARKLGATHTVNSRSTDPVEAVRELTGGFGADVVIEAVGRPETYKQAFYARDLAGTVVLVGVPTPEMQLELPLLDVFGRGGALKSSWYGDCLPSRDFPMLIDLYRQGRLDLDTFVTETIALEDVEKAFERMHHGDVLRSVVIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-09-29" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JXN1</accession>
    <name>A0A2M9JXN1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Acetyl-CoA acetyltransferase</fullName>
            <ecNumber evidence="6">2.3.1.9</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CG723_12250</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CB01635</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the thiolase-like superfamily. Thiolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.9" evidence="6"/>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN11645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN11645">
        <property type="protein sequence ID" value="PJN11645"/>
        <property type="gene ID" value="CG723_12250"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003985">
        <property type="term" value="F:acetyl-CoA C-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd00751">
        <property type="entry name" value="thiolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002155">
        <property type="entry name" value="Thiolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020617">
        <property type="entry name" value="Thiolase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020613">
        <property type="entry name" value="Thiolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020616">
        <property type="entry name" value="Thiolase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02803">
        <property type="entry name" value="Thiolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00108">
        <property type="entry name" value="Thiolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000429">
        <property type="entry name" value="Ac-CoA_Ac_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01930">
        <property type="entry name" value="AcCoA-C-Actrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00737">
        <property type="entry name" value="THIOLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Thiolase_N" evidence="4">
        <location>
            <begin position="5"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="domain" description="Thiolase_C" evidence="5">
        <location>
            <begin position="269"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-thioester intermediate" evidence="2">
        <location>
            <position position="89"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="2">
        <location>
            <position position="347"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="2">
        <location>
            <position position="377"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000429-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PJN11645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="391" mass="40427" checksum="088B9E58FD5FC524" modified="2018-04-25" version="1">MRDAVIVDAVRTPVGKRGGSLAGIHAVDLSAHVLTALAERTCLDPATVDDVVWGTVSQVGEQAGVVGRFAALAAGWPESVPGVSVSRACGSSQQSVHFAAGLVAAGQYDIAVAGGVESMSRVPMGSARSVPDAGKAYGPLVLNRYFPDGDGEFDQGVGAELIAEQYGFSRAQLDRHALDSHERAARAIDEGRFTGQITPVTVTAEDGTTRVFDTDEGVRRGSTLEKLASLKTPFKADGVVSAGNSSQISDGAAALLITTSEIARQNRWTPIARVHTAVLAGADPVTMALGPAPATAKALKRSGLSIGDIGAFEINEAFAPVTLAWLKETGADYSLMNPLGGAMAIGHPLGGSGARLMTTLVHHMRDNNIRYGLQAMCEAGGMANATILELL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JXW5</accession>
    <name>A0A2M9JXW5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_12725</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN11719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN11719">
        <property type="protein sequence ID" value="PJN11719"/>
        <property type="gene ID" value="CG723_12725"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041413">
        <property type="entry name" value="MLTR_LBD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17765">
        <property type="entry name" value="MLTR_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="47"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN11719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="298" mass="31897" checksum="D738A29364486085" modified="2018-04-25" version="1">MDGVNDIGDTGAGATLTTGGSQRGLGDFLRARRARVTPEHVGLSGGRRRRVRGLRREELAQLAGISVDYYVRLEQGRATQPSAEVVGALAGALGLDTAERGHLATLAGARQGPAPEARVSPMLRRLLDSMAGFPAFATNHRLDVVAWNALGAELIGGLGEPAGRDRNNARYLFLDPASRVVHPEWEDRAAEAVGQLRVWSGRYPDDTELAALIAELTALSQEFRRIWDSGEVVMCAAGRKRLRHPVAGLLTLDFETLHVPAVPGETGLVVHVFSAEEGSEEATALARLTEAVTVAHRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JYC2</accession>
    <name>A0A2M9JYC2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ArsR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_13565</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AHA1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN11858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN11858">
        <property type="protein sequence ID" value="PJN11858"/>
        <property type="gene ID" value="CG723_13565"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013538">
        <property type="entry name" value="Activator_of_Hsp90_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001845">
        <property type="entry name" value="HTH_ArsR_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08327">
        <property type="entry name" value="AHSA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00778">
        <property type="entry name" value="HTHARSR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00418">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50987">
        <property type="entry name" value="HTH_ARSR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH arsR-type" evidence="2">
        <location>
            <begin position="1"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN11858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="262" mass="29427" checksum="77030F56040F00CC" modified="2018-04-25" version="1">MDQAFKALADPTRRRLLDRLREHNGQTLRELCDRLDMARQSATQHLDILERAGLVTVVRRGRERLHYLNPAPIHEIEERWISEFDKPRLQAISAIKNQAEEYAMTSGSASVPSYVYVTYIRASAEQVWQALTDADLTARYWGHANVSDWEPGSAWEHRRVDGSGAVDVVGQVLKAEPPTRLVITFEDTPDAQAPRDPSVVTFLVEPHEDIVRLTVTHENLPNAEMLNGISQGWPAVLANLKSLLETGEVLPQAPWDMAGTHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JYL2</accession>
    <name>A0A2M9JYL2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Sugar ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CG723_14050</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CB01635</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN11938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN11938">
        <property type="protein sequence ID" value="PJN11938"/>
        <property type="gene ID" value="CG723_14050"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="36"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="103"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="138"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="179"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="238"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="291"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="100"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PJN11938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="327" mass="34962" checksum="3292442FF1887FB2" modified="2018-04-25" version="1">MTATTHAPATAAAPPREADGARRKAQRAAGRRRGGAAGVLMAPFFILLTLVFLIPVATAVWLSFFSDDQPGLGFGPEHTVFVGLRSYAAVLTDPSFLSGLGTVALYCVIYIPVMTIGSLALALLLDSGLVRLRSWAQLGLFLPHAVPGIIAALIWLYLYTPGISPIIDVLGKADITVNFLGLHTAIPSIVNIAVWSNLGYNMVVFYAALQAVPREVLEASVVDGAGPVRTALQVKAPLVRSSIVMVAMFTLIWALQLFTEPMLLRAGSQVVDARFSPSMYIYDAAFSRNNYSLAAAASVILLVITIAVSYGVTRWTNRVNSAEENAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JYR5</accession>
    <name>A0A2M9JYR5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ABC transporter substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_14545</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN12023.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN12023">
        <property type="protein sequence ID" value="PJN12023"/>
        <property type="gene ID" value="CG723_14545"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006059">
        <property type="entry name" value="SBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01547">
        <property type="entry name" value="SBP_bac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014760776" evidence="1">
        <location>
            <begin position="39"/>
            <end position="446"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN12023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="446" mass="48809" checksum="90936B975D32FD13" modified="2018-04-25" version="1">MTGRHPPIGPARTSTGRTFPSRRTLLRAAVAGTSAAVAAPLVTACGTAAGQPPGKVALHGDNPSWAAPLKAAGEAMRSVDGLELVPEVIPSLESFEQVVKSSLRTSKTPDMLKYWSGYRLQDLARTGGIVDLSDHWASAARKGWVDPALRSAVSYRGRVYGLPMNLAYYVFFYNPEVFRANGLRKPETWDDFLHVAGRLKRAGITPLHGTTAGRWPAFIWFQEILSRQDPQFYEDLLNGRARYTDPRAERALRTIASFFDKDWFTSMDMEHAAAAAGVVHGKVGMLPCGSWLGGTFVGVGGKPGKNVDAFVLPMQNTRVRPAAVFETSALVCTVKGPDRDEAYRAAGAWPHPQVMKAFSHTLQDGCPNPTVTPANTIIDGVATTVRESKARLLNRFWELGPPELVESTVDDLAGFLINPSSYRKVLRTMQDRADEAWKVWKEAEES</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JYT6</accession>
    <name>A0A2M9JYT6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CG723_13925</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN11917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN11917">
        <property type="protein sequence ID" value="PJN11917"/>
        <property type="gene ID" value="CG723_13925"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PJN11917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="136" mass="15060" checksum="45E50D86A611CA0C" modified="2018-04-25" version="1">MQDEQRRPFDQLPQQLRAVGPGWHPLLLRLHEGLRVHAAGYRVDDLKEKFGTVRIQVSGVPDSAGGEICVLLAAAEERSAVTCEFCGAAGRQRRRDDASLGWIKTVCDSCHCAWSQHAIMIVGGAVRSRPDRRTQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JYX1</accession>
    <name>A0A2M9JYX1_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Histidine kinase</fullName>
            <ecNumber evidence="4">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CG723_08235</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CB01635</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="4"/>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN12083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN12083">
        <property type="protein sequence ID" value="PJN12083"/>
        <property type="gene ID" value="CG723_08235"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038318">
        <property type="entry name" value="KdpD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025201">
        <property type="entry name" value="KdpD_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003852">
        <property type="entry name" value="Sig_transdc_His_kinase_KdpD_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006016">
        <property type="entry name" value="UspA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13493">
        <property type="entry name" value="DUF4118"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02702">
        <property type="entry name" value="KdpD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00582">
        <property type="entry name" value="Usp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="384"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="417"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="462"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="9">
        <location>
            <begin position="609"/>
            <end position="818"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PJN12083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="835" mass="88848" checksum="B7F016CD4D7171BE" modified="2018-04-25" version="1">MGDVRPGRLKVYLGAAPGVGKTYRILDEARRRAARGADVVVGFVECHGRPGTEAMLDGLEVVDRVSCAYRGGAFTEMDLAAVLARRPQVAIVDEFAHSNVPGGGRNPKRWQDIEELLAAGIDVISALNIQHLESLNDVVEKITKVPQHETVPDEVVRRARQIELVDMPPEGLRRRMAHGNIYAPEKVDAALANYFRPGNLTALRQLALLWVADRVDEALQTYRSEHGIGGVWETRERVVVALTGGPEGDTLIRRAARIADRSAGGDLLAVHVTRSDGLAAGTSHASLARQRRLVEDLGGSYHSVVGDDVATALVEFARAENATQLVLGTSRRGRLERFVTGRGTGETVVKFSSDIDVHMVTHERAGRGTLLPSRRRTLSTVRRIAGPVAGLLLPVALTFLLDLDVARDRLNLTSEALLFLLAVVGVACIGGVVSAVIASVTASLLLNYWFIPPRGHFTLNDTNALLALGVFVVVAAIVAAVVDRSLRLSRRSARATAEAETMSSLAGTIVRGGATIPALVKRTRETFGMDSAELVDEPPAEDGATVVPAGPGAFLVLRGRPLPSSERRVLAAFAAHVGAAVERARLAEVAAEVEPVKAADRMRTALLRAVGHDLRTPLAAGWAAVSSLRSKDVEFSDADRDELLATADESMAKLNRLIENLLDLSRLQAGALTLNLRPTTLDEVLPAALADTPEVEVGDLDEVPAVLADPPLLERVVANLAGNAARHSPAGRMVLLTASSHAGRVELRVVDRGPGLPPTDRDRLFEPFQRLGDTDNATGLGLGLALSRGLAEAMDGTLVPEDTPGGGLTMVLSLPFAERAEHPSGTQSVGGAHEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JZV9</accession>
    <name>A0A2M9JZV9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GNAT family N-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_04780</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000002">
        <property type="protein sequence ID" value="PJN12370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN12370">
        <property type="protein sequence ID" value="PJN12370"/>
        <property type="gene ID" value="CG723_04780"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="18"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN12370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="165" mass="18264" checksum="B0088980DDF84EC9" modified="2018-04-25" version="1">MNSPWTVTPEPFDSTVAAELWRAYYTEVSDRWYLLHEGHTTDPDELEREVAADTGAYLAAPGGVLLVARYRGEPAGTAGVRMIDASTGELKRVFVRPEMRGKGGGSVLLAEVESSARGLGAERVVLDTRGDLVEARMLYARHGYQETAPHNDEVFAEHWFTKKLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K040</accession>
    <name>A0A2M9K040_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">PAP2_3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CG723_04820</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CB01635</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the glycosyltransferase 87 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000002">
        <property type="protein sequence ID" value="PJN12377.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN12377">
        <property type="protein sequence ID" value="PJN12377"/>
        <property type="gene ID" value="CG723_04820"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016758">
        <property type="term" value="F:hexosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026841">
        <property type="entry name" value="Aur1/Ipt1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018584">
        <property type="entry name" value="GT87"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09594">
        <property type="entry name" value="GT87"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14378">
        <property type="entry name" value="PAP2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="75"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="131"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="156"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="184"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="244"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="274"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="316"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="346"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="474"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="505"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="558"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="587"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="611"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="domain" description="PAP2_3" evidence="9">
        <location>
            <begin position="442"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="638"/>
            <end position="660"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF14378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PJN12377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="660" mass="71361" checksum="011E3FE5B47C0CF8" modified="2018-04-25" version="1">MVRAGLWLIAAVLAVRQVVAVLSTPSGERLTDLETWIGPEGVLHVKDSLYDADRFTGTPFGGLVLKPLARGAEQALGWAWTFGTLGLVVVLGLVAARALPKPVTRRTSLLAAPVAVSLLMLSLPVRNTLHLGQTSIIPVLLVLLGCFAARGEKSSGLLIGIGAALQPTVLLFAPLLWFTGRRRAAVSSGVTFAACTLLAWAAMPHDSWTYWVHHLAGAGLGSSPDGLANQSLHGALLRFGLEGPLEIGLFLLLAVAVAVVGLRRAVRYAQDGQLLLAVALTGCVAVAVSPTTWQHQLLWVLLAVVGRVGKKASDRYVWPVAVILVMTLPARMLLPGTALADPLRDNVVLIAAVAAATLVPFLSRTAPEYRAPVPTEYAKPVPSRWSRVPLMPFWRRVLTRPNLLLELLLIRVGYYAYQQVRLAATGGTTTGGRATAEAHGTQVHSLEKFLHIDIEHWVNHAVVHVPWLKSFFNFYYESFHFIVPLCVLGILYVRRPAQYRWARSALGFATVLALIGFWFYPLAPPRLMPSLGFIDTVHGVQDFSKPDYGTLTALTNQYAAMPSLHFGWSLWCGLVIAVLAPKWWMKAIALLHPLFTISAIIATGNHWVLDAVGGATVVGAGFGLTYLLCGPRARLTSGTVPEQSKGEVGHARLPAEHHRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-09-29" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K0C9</accession>
    <name>A0A2M9K0C9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CG723_05895</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CB01635</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000002">
        <property type="protein sequence ID" value="PJN12564.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN12564">
        <property type="protein sequence ID" value="PJN12564"/>
        <property type="gene ID" value="CG723_05895"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd16913">
        <property type="entry name" value="YkuD_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.440.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041280">
        <property type="entry name" value="Big_10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005490">
        <property type="entry name" value="LD_TPept_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038063">
        <property type="entry name" value="Transpep_catalytic_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17964">
        <property type="entry name" value="Big_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03734">
        <property type="entry name" value="YkuD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141523">
        <property type="entry name" value="SSF141523"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014708939" evidence="4">
        <location>
            <begin position="31"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="domain" description="Big_10" evidence="6">
        <location>
            <begin position="54"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="domain" description="YkuD" evidence="5">
        <location>
            <begin position="248"/>
            <end position="367"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF03734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF17964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PJN12564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="419" mass="44644" checksum="D6EB34F1643218A9" modified="2018-04-25" version="1">MNNSPRIRMVMGCTLLVTALGASVTGCSGSSHPLSAKPYDAAGEIGFSGESGSKKADPDKPIEITSEGDEARITDVTATDEIGRYVVGELSADGSRWHSTAPLAADAHYTVHVSTEDDEGAPGRKVLTFDTGHPDKKKSLKVTFGPEAGKYGVGQPVTAELSAAVKDKAARAVVERALKVDSEPAVAGSWTWVDDKTLHFRPEEYWPAGATVEAHSTLDGIKIGDRLWGGASKPLRLTIGDRIEAVTDAGSHQMTVYRNGRVINTIPVTTGKPGFETRNGVKVVLGKERFVRMRSTSIGIAEGSSESYDMPVYFATRVTWSGEYVHAAPWSQGSQGYANVSHGCTGMSMSNAEWFFNTVRTGDVVKVINSNGAQMDPFGNGFGDWNLSWKNWEKGSAVQAVAGDGGRSTVQAARLSPEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K0E1</accession>
    <name>A0A2M9K0E1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Sensor histidine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CG723_06030</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000002">
        <property type="protein sequence ID" value="PJN12588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN12588">
        <property type="protein sequence ID" value="PJN12588"/>
        <property type="gene ID" value="CG723_06030"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045975">
        <property type="entry name" value="DUF5931"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011712">
        <property type="entry name" value="Sig_transdc_His_kin_sub3_dim/P"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19354">
        <property type="entry name" value="DUF5931"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07730">
        <property type="entry name" value="HisKA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="43"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="76"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="127"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="151"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="domain" description="DUF5931" evidence="4">
        <location>
            <begin position="5"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="domain" description="HisKA_3" evidence="3">
        <location>
            <begin position="190"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="domain" description="HATPase_c" evidence="2">
        <location>
            <begin position="306"/>
            <end position="399"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02518"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF19354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PJN12588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="409" mass="43247" checksum="4EA32B74C3E40DAD" modified="2018-04-25" version="1">MARRERVMRMSVEQPLWRALTAYRLLTMLYAIGLFATEQDRFVRPWVAIGYFAVLVVWTLATLPRVANAASCTKRFLTVDLIVALVGILLTPLAVGHSGIVAGGPTLPSIWTAGAVLAYAVKGGWRWAAFASLLVGVANVLQRGAFSRDTLHNVLLVCIASIAIGYVVEVARASERTLARALEIEAATRERERLARDIHDGVLQVLAMVQRRGTALGGEAAELGRMAGEQEVALRTLVAGGLVPASRASEDASQGALVRAVEEPDELPDTSAPSDLRSLLAPHAGARVSFAEPGAPVFLAPVAAKELAAAVSAALDNVRRHAGTDARAWILVEDEPDAVIVTVRDDGPGIPEGRLAQAEGEGRLGVAQSIRGRLRDIGGTAELISVPGQGTEVELRVPKVSRGKAGSGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K0T5</accession>
    <name>A0A2M9K0T5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_06990</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000002">
        <property type="protein sequence ID" value="PJN12751.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN12751">
        <property type="protein sequence ID" value="PJN12751"/>
        <property type="gene ID" value="CG723_06990"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009097">
        <property type="entry name" value="Cyclic_Pdiesterase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55144">
        <property type="entry name" value="SSF55144"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="195"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN12751.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="226" mass="24714" checksum="C7BA87D63A26877F" modified="2018-04-25" version="1">MCGTSRIWPAAGHRGGSVTGWRAVSSEDGWPDVPGDTALTIRIPEADAFVRAPFPAHITVLYPFLPAARITPEVHAELAALFADRAPFVLTFAEFRRYPGVLYLPPAPDHPVRALTRAVRERWPEAVPYRGVFGPEGLDPHLTLANDEGPETYERAYDALERELRPMLPVTARVDSVRLIVTDGRAWEDSAVYDLGRSPAPPAPPTQPAPPAQVLRAASTALSRRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-09-29" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K0Z5</accession>
    <name>A0A2M9K0Z5_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 7">Transaldolase</fullName>
            <ecNumber evidence="6 7">2.2.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7 8" type="primary">tal</name>
        <name evidence="8" type="ORF">CG723_07275</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CB01635</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 7">Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>D-glyceraldehyde 3-phosphate + D-sedoheptulose 7-phosphate = beta-D-fructose 6-phosphate + D-erythrose 4-phosphate</text>
            <dbReference type="Rhea" id="RHEA:17053"/>
            <dbReference type="ChEBI" id="CHEBI:16897"/>
            <dbReference type="ChEBI" id="CHEBI:57483"/>
            <dbReference type="ChEBI" id="CHEBI:57634"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="2.2.1.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4 7">Carbohydrate degradation; pentose phosphate pathway; D-glyceraldehyde 3-phosphate and beta-D-fructose 6-phosphate from D-ribose 5-phosphate and D-xylulose 5-phosphate (non-oxidative stage): step 2/3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3 7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 7">Belongs to the transaldolase family. Type 2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.2.1.2" evidence="6 7"/>
    <dbReference type="EMBL" id="NNBL01000002">
        <property type="protein sequence ID" value="PJN12805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN12805">
        <property type="protein sequence ID" value="PJN12805"/>
        <property type="gene ID" value="CG723_07275"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00115">
        <property type="reaction ID" value="UER00414"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004801">
        <property type="term" value="F:transaldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006098">
        <property type="term" value="P:pentose-phosphate shunt"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00955">
        <property type="entry name" value="Transaldolase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00493">
        <property type="entry name" value="Transaldolase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001585">
        <property type="entry name" value="TAL/FSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004732">
        <property type="entry name" value="Transaldolase_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018225">
        <property type="entry name" value="Transaldolase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10683">
        <property type="entry name" value="PTHR10683"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00923">
        <property type="entry name" value="TAL_FSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036915">
        <property type="entry name" value="Trnald_Bac_Plnt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00876">
        <property type="entry name" value="tal_mycobact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01054">
        <property type="entry name" value="TRANSALDOLASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0570">Pentose shunt</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0704">Schiff base</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="active site" description="Schiff-base intermediate with substrate" evidence="7">
        <location>
            <position position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003518"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00008426"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00013151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PJN12805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="372" mass="40279" checksum="42B0EB67DFD7DEC9" modified="2018-04-25" version="1">MTDALKRLSEEGVAIWLDDLSRKRITSGNLAELIDQQHVVGVTTNPSIFQKAISHGDGYEQQLADLAARKVTVEEAIRMITTADVRDAADILRPVFEATAGQDGRVSIEVDPRLAHNTTATVAEAKQLAWLVDRPNTLIKIPATKAGLPAITEVIGKGISVNVTLIFSLERYREVMDAYLAGLEKAKAAGLDLSKIHSVASFFVSRVDSEIDKRLDALGTDEAKALKGKAALANARLAYEAFEEVFSSDRWAALDKAQANKQRPLWASTGVKDPAYKDTLYVVDLVAPGTVNTMPEATLDATADHGEVTGNTIAGTYDQSRTEIAAVEKLGISYDDVVQVLEDEGVDKFEASWNDLLKSTEAELQRLAPSEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K1B7</accession>
    <name>A0A2M9K1B7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Peptidase S8</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CG723_07900</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CB01635</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the peptidase S8 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000002">
        <property type="protein sequence ID" value="PJN12918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN12918">
        <property type="protein sequence ID" value="PJN12918"/>
        <property type="gene ID" value="CG723_07900"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000209">
        <property type="entry name" value="Peptidase_S8/S53_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023827">
        <property type="entry name" value="Peptidase_S8_Asp-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022398">
        <property type="entry name" value="Peptidase_S8_His-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023828">
        <property type="entry name" value="Peptidase_S8_Ser-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015500">
        <property type="entry name" value="Peptidase_S8_subtilisin-rel"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00082">
        <property type="entry name" value="Peptidase_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00723">
        <property type="entry name" value="SUBTILISIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="SSF52743"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00136">
        <property type="entry name" value="SUBTILASE_ASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00137">
        <property type="entry name" value="SUBTILASE_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00138">
        <property type="entry name" value="SUBTILASE_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 5" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0720">Serine protease</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014935561" evidence="7">
        <location>
            <begin position="38"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_S8" evidence="8">
        <location>
            <begin position="179"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="197"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="340"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="210"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PJN12918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="515" mass="52087" checksum="C4C05F8F604A5BF7" modified="2018-04-25" version="1">MTAPLARSRSIRRSIAVPAGMAMATALAFLPNVTASAAGQAPQAPQASVATDGPSLSYVVNVRSGHGASGAVQKEITKAGGTVVVAYDKIGVIVAHSSNPDFAKTIRKARGVDSAGATRTAPLPAQSTADLGTPKALTAAQLAATAGQAAAGQDPLEPLQWDLPAIKADKAHEKSLGSSKVTVAVIDTGVDDTHPDIAPNFDRGASANCVSGKPDTTDGSWRPSASESPHGTHVAGEIAGAKNGLGITGVAPGVKVSGIKVGNPDGFFYTEAVVCGFVFAAEHGVDVTNNSYYTDPWYFNCTDDPDQKALVKAVARASQYAEKKGAVNVAAAGNERYDLASDEITDPSSPNDTTPGDRVVDPSKCFDIPTQLPGVVTTAATGAKGLKSSFSNYGRGIIDIAAPGGDSTAYQTPAPPATSGLILGPLPGGKWGYMAGTSMASPHVAGVAALIKSTHPHASAAAVKALLYAQADATPCTDPYDIDGDGKVDAVCEGGKNKNGFYGHGIADALDAVTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K2A8</accession>
    <name>A0A2M9K2A8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_01310</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000001">
        <property type="protein sequence ID" value="PJN13253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN13253">
        <property type="protein sequence ID" value="PJN13253"/>
        <property type="gene ID" value="CG723_01310"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="39"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN13253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="224" mass="23765" checksum="F71826C85191EB15" modified="2018-04-25" version="1">MTRYADIPKPIRSGIVVVDPDRGTPQRVIVLQFNPDTLERSIAPQTAGDSGDGGGGGDRNEALRLKGPAQETWKFTAEIDATDQLEIAAPDGIHPQLATLEMLVQPTTAQLRAASRLSQKGTIEISPIEMPLTLFTWGSKRVMPVRLTELSVNESAFDVNLNPIRASLSIGMKILTVSDLPAGHRGADLYMAHLAQKERLAAAARGGSLGALGLPGADVLSGRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K2F5</accession>
    <name>A0A2M9K2F5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CG723_01610</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000001">
        <property type="protein sequence ID" value="PJN13302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN13302">
        <property type="protein sequence ID" value="PJN13302"/>
        <property type="gene ID" value="CG723_01610"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012545">
        <property type="entry name" value="DUF1697"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36439">
        <property type="entry name" value="PTHR36439"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08002">
        <property type="entry name" value="DUF1697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF008502">
        <property type="entry name" value="UCP008502"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PJN13302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="183" mass="19549" checksum="19C1D8F3523233DD" modified="2018-04-25" version="1">MATKAYAALLRGINVGGSRKVPMARLRPLIEGLGHGGVRTYLQSGNATFTSDHGDESTLAAELSTAIEKEFGFGVDVIVREHAYLASVVDACPFPAASCKGKQLHVTYFSGPVDPERFASVDPAEFAPEDFRLGPRELYLYAPEGLGRSKLGAVLARPALNKGLIATSRNWNTVVKLVEMTGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K2M6</accession>
    <name>A0A2M9K2M6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_02060</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000001">
        <property type="protein sequence ID" value="PJN13384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN13384">
        <property type="protein sequence ID" value="PJN13384"/>
        <property type="gene ID" value="CG723_02060"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="29"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN13384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="66" mass="7122" checksum="27C4CBD848111798" modified="2018-04-25" version="1">MHGDVVDHLRTAEPFDAACAIGSMAFADPGSGRDVARSGPRSRTPVRGRSVRHRIRQERAGVLVDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K2Q0</accession>
    <name>A0A2M9K2Q0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_02190</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000001">
        <property type="protein sequence ID" value="PJN13406.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN13406">
        <property type="protein sequence ID" value="PJN13406"/>
        <property type="gene ID" value="CG723_02190"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="2">
        <location>
            <begin position="182"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN13406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="295" mass="31511" checksum="BF437CD6125F463E" modified="2018-04-25" version="1">MLRDRTAEQAGAPDHTGTPGRYGTPLAPPEALRPWITEIDSINSVGSSDFGQGDTRPITHVPDAATRLVFRVLPDGGTDVVAIGPRTKASYYEEKRLPMCLQLRFRPGAARPLLGVSTRELVGRAEPLESLPGEAGRRLARGLAALGPAPDPDAVLARMTELLPDGLTPRDRGERARDGLVRAAVEALSTAPGRDRPGTVTEVARQLAVSERQLRNLFADGVGLSPKHFARIDRVRQVLAGAGAEEHPRWAGLAHATGYYDQSHMTAEFRALLGVPPTAFATGRLPAARPCGPGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K315</accession>
    <name>A0A2M9K315_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">SAM-dependent methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_02795</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000001">
        <property type="protein sequence ID" value="PJN13509.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN13509">
        <property type="protein sequence ID" value="PJN13509"/>
        <property type="gene ID" value="CG723_02795"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041698">
        <property type="entry name" value="Methyltransf_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13649">
        <property type="entry name" value="Methyltransf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransf_25" evidence="1">
        <location>
            <begin position="52"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN13509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="240" mass="25785" checksum="E6D775779641C554" modified="2018-04-25" version="1">MSVTSRYKDAWESFWREAPGEPGGVFWDAEPALTAKVHLALFEPHLTEGLPVVDLGCGNGTQTRFLADRYPRVVGADLSDAALGHARRADPAGRADFRQLDATEQTEAHQLHSELGDANVYMRGVLHQCETDDRQALVDGIAALVGERGRAFVVELAEAARPVLMSLAQSPTGPPAKLAPVFAHGIAPCEVSDAAVPDYVRTAGLDVLASGELPLTTTEYTPDGTRIELPSRWLVVGRAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K3H4</accession>
    <name>A0A2M9K3H4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">TetR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CG723_03820</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000001">
        <property type="protein sequence ID" value="PJN13681.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN13681">
        <property type="protein sequence ID" value="PJN13681"/>
        <property type="gene ID" value="CG723_03820"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039538">
        <property type="entry name" value="BetI_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13977">
        <property type="entry name" value="TetR_C_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0678">Repressor</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="3">
        <location>
            <begin position="9"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="2">
        <location>
            <begin position="32"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PJN13681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="211" mass="22925" checksum="48EC03F5581B6183" modified="2018-04-25" version="1">MARVRLSVAERREELLRAAIEQIEARGVAAVRIADVAAALGVSNALVLYHFSTKEKLVAAAFAHAAEGDLAHLRKLLGKRTTALRRLRSAVRWYAPTGQAKGWRLWIEGWSAALREPALREVTRDLDKQWKAALTEVVAEGVAAGEFRCPDPAGAALRLTALLDGLAVQMTAYTGTVSRTRMQEWVDDALARELGLERADLTATTPAATTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K3J0</accession>
    <name>A0A2M9K3J0_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Peptidase M60 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_03900</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000001">
        <property type="protein sequence ID" value="PJN13693.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN13693">
        <property type="protein sequence ID" value="PJN13693"/>
        <property type="gene ID" value="CG723_03900"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.390.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035423">
        <property type="entry name" value="M60-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042279">
        <property type="entry name" value="Pep_M60_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031161">
        <property type="entry name" value="Peptidase_M60_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17291">
        <property type="entry name" value="M60-like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13402">
        <property type="entry name" value="Peptidase_M60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01276">
        <property type="entry name" value="M60-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51723">
        <property type="entry name" value="PEPTIDASE_M60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase M60" evidence="2">
        <location>
            <begin position="83"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN13693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="462" mass="50078" checksum="56F132E1B04DD5BC" modified="2018-04-25" version="1">MRPARTPSATSADAAVTADTPATSGFSRRGMLATLAGAGAATLLGTGTASAHAVRGVGLTVPLIARPSAETERLRLGQALRATEFQPTGQYVPAGAALRFDVLPHDGLVPTLWIGQWDYYGTVTEPRSYALKPGANTVTDPHGGPVYFSLEGHGERAAVKFRSGATAMPVFTLGRTSEADYQRQLDTLTDVPVVELHAPRTIMTLTRDGALLHRDQDHAALLRLVEQIIEAESRISGLDGSKPVHRPKAGGYHFTEVSVVPSGVGAYATHGYNGFPRAYLDRATTVDGLRTRGWGLYHELGHLHQQMAYKPTGLTEVTVNIYSLAVQRALGQPSNLLTVDPKTGLNPFQSARAKFGTDGLTYEKSFGAYEKLVPLRQLELAFGDDFWPRLHRLVREENPQSDYTETAKRYRALSTYASRVSGRDLTDFFVRDWAFPIDATGLAEIAALQLPKPTVEPATLTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K3J1</accession>
    <name>A0A2M9K3J1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_03925</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000001">
        <property type="protein sequence ID" value="PJN13696.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN13696">
        <property type="protein sequence ID" value="PJN13696"/>
        <property type="gene ID" value="CG723_03925"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006059">
        <property type="entry name" value="SBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13416">
        <property type="entry name" value="SBP_bac_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014747730" evidence="2">
        <location>
            <begin position="38"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="260"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN13696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="557" mass="59617" checksum="60370FA1CDC519F3" modified="2018-04-25" version="1">MPRSTPINRRTLLRTSLGLGLGLAAAPLLTACGDGGAAEKSAAKSRKVLPSTVTANTVKADLPGTAAGVPNAFFSYPKTPVRSVEGTPLKGAKTVKAFTETYAPPAPARGRNAAWQAIEKRLGGTVDITAVAADDYPAKFSTMVAGGDLADVFMYPETGGVDHKAAFLAAECADLTPFLSGDKVKTYPNLAAIPASAWQQGLYGDTLYGVPITRYGTSGAGFYRHDLFKEVGVDSLDQITDLDRFFEVCKELTQPKKKQYAIIAGATSMLAMSAGAPYFWSMDKKTGKFTADLETDEYRSAVEMAAKLYKAGCYYPGTLAMTGAQKAQYTDLFKNGKGAYVYDGMPAYLQPSSGYVDAMAAIDKSYDVRPFVPIGTKAVTWTDNATLSESFVKKAPKARVEQILRLLDFIAAPFGTEEYTLINFGVEGADFKRDAKGIPVLTPTGSQDIGVPWGKLASGIPALFSPTSKDAATYAHEAYTKLIPMLEKSDYLDYTSPTWDSKGYGSLLTLKGDGIKDIVSGRKSMKDYDALVKDYLAKGGEQCRSEFEDAAQKGTGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K3N7</accession>
    <name>A0A2M9K3N7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_00860</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000001">
        <property type="protein sequence ID" value="PJN13732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN13732">
        <property type="protein sequence ID" value="PJN13732"/>
        <property type="gene ID" value="CG723_00860"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="253"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN13732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="359" mass="38919" checksum="09E1C6C1F289AFCF" modified="2018-04-25" version="1">MTPAWLARHVVPVVRALSERGAPAVQLRRGWLHGPHVDVLALAVPGAPDWTEVADLLDAGPLDPPRALTEEAYLEQAREFGRLEAVQPPYLPLHEHGAVSRVGPADTASREPRLDQFRTVVLGALNKPLLRMIDGIAAEPATATVRLAEAFAALVDTHFLGPAYGVFSPRSHVEAFLAWAAPTKDVRPVFQERLAKDAPRLRTVVEQRLSGEVSAGAAEWRTAFAYSSGALESAVAAGTLTLDLLDSVTDGVDRSEMGPPGATRVVPQGDQPDSDFHRAVGDSGVVADPSRWFAAFRLLTNLFYEQLPLLTVSPMQRYYMCFAIAETVDDVLGVSWQDRLNDRRDRMAATAADPTGAPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K3Z8</accession>
    <name>A0A2M9K3Z8_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HATPase_c domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_01910</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000001">
        <property type="protein sequence ID" value="PJN13757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN13757">
        <property type="protein sequence ID" value="PJN13757"/>
        <property type="gene ID" value="CG723_01910"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13581">
        <property type="entry name" value="HATPase_c_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HATPase_c" evidence="2">
        <location>
            <begin position="47"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN13757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="163" mass="17431" checksum="186D9ED77AB813E1" modified="2018-04-25" version="1">MKRLVRGRVPTTVAGRSPTEEAPGGDGAATDGTTDGGAKLRRTLGRSDLRAVPEARRALRELLDEWGPPERSQTAELLTSELVTNALVHTDHDAVLTATVGPKRLRVEVRDFVGRRPRLRVPVADDGTNGRGLVLVQSLADAWGVRALGVGKVVWFELDGGPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JEN1</accession>
    <name>A0A2M9JEN1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_45395</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000053">
        <property type="protein sequence ID" value="PJN05338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN05338">
        <property type="protein sequence ID" value="PJN05338"/>
        <property type="gene ID" value="CG723_45395"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014650723" evidence="2">
        <location>
            <begin position="28"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="25"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="144"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="157"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="174"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN05338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="298" mass="31129" checksum="842E8146AD91C5BF" modified="2018-04-25" version="1">MQRKAYVPGVAALLAALLTGCTGGSGATGDATDSKPGDVGTSAAAARPGKYRTLPEPCRQPDKGTLDKMLPGIKELPEGDQRDKAYEGAATVTYDTDRRVGCRWKDDGADATHLLLVDFERVVSYDNAVSDDTEAGQVFASKQTEAHLPAPVPTDPTSPTTSHSSSAGTDKDTADAENGTEKGTADEETDSGKPDEEGSDEASVDASSSPPDDSVPGADLQPRALEGLADEAFLNDQLTASASTGGHRTVTVVFRTSNVIVTVEYEQQPGTSAKVPDSKEMQDRARELARKLAGTLSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JEW5</accession>
    <name>A0A2M9JEW5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_45000</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000049">
        <property type="protein sequence ID" value="PJN05428.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN05428">
        <property type="protein sequence ID" value="PJN05428"/>
        <property type="gene ID" value="CG723_45000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="42"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN05428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="109" mass="12688" checksum="6CF645939C593E2A" modified="2018-04-25" version="1">MTIKSLTREGGLKRNKLTHKHTGLKDLFYALVRMQDTRPKVVDDLKRTNDELQQRLTRLRAERDRLCTEVQQLVRVVHVLEVENQQLREAADSDGVVRVLSGQQRPSTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JEY9</accession>
    <name>A0A2M9JEY9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">IS200/IS605 family transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_44650</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000048">
        <property type="protein sequence ID" value="PJN05444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN05444">
        <property type="protein sequence ID" value="PJN05444"/>
        <property type="gene ID" value="CG723_44650"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1290">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002686">
        <property type="entry name" value="Transposase_17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036515">
        <property type="entry name" value="Transposase_17_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01797">
        <property type="entry name" value="Y1_Tnp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01321">
        <property type="entry name" value="Y1_Tnp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143422">
        <property type="entry name" value="SSF143422"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Y1_Tnp" evidence="1">
        <location>
            <begin position="18"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM01321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN05444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="143" mass="16584" checksum="28634F0D200CC8A0" modified="2018-04-25" version="1">MSPRWNPNPDVRTGRHVVYNLHVHLVFVTKYRRKAFTDAMLTRTEEIMREVCADFEADLKQFNGEQDHVHLLVHYPPKVQLSKLVNSLKGVSSRRLRQEHSAHVRRYLWGGHFWSGSYFAGSCGGAPLTVVKQYIENQQRPIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JFE8</accession>
    <name>A0A2M9JFE8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">LysR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_43795</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LysR transcriptional regulatory family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000044">
        <property type="protein sequence ID" value="PJN05621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN05621">
        <property type="protein sequence ID" value="PJN05621"/>
        <property type="gene ID" value="CG723_43795"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005119">
        <property type="entry name" value="LysR_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000847">
        <property type="entry name" value="Tscrpt_reg_HTH_LysR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00126">
        <property type="entry name" value="HTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03466">
        <property type="entry name" value="LysR_substrate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00039">
        <property type="entry name" value="HTHLYSR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50931">
        <property type="entry name" value="HTH_LYSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH lysR-type" evidence="2">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN05621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="297" mass="31765" checksum="B1E908438CFEDE0F" modified="2018-04-25" version="1">MELRQLEHFVAVAEEANFTRAAARLHVVQSAVSTTIKNLERELGTPLLERTTKRVLLTDAGAALLPRAHAALNAAREAADAVAEVRGGLRGTLRLGTMTTVGLIDFPALLSEFHRRHPGVLLQTSAAASGSRGLIDALLERRLDLAFVSLPGPHPTGITLTDLVTSVLDLVVPADHPLAKRRTVPITELAGLDFVDFPVSYGIRTVADQAFAAASVTRRVALEITDVPTGVAYVRNGLGVALLPRPALAKAEDVATLTIDDADLDWPFSLAVPSERTPSRAARALIAITHEFLIWRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JFG4</accession>
    <name>A0A2M9JFG4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Alpha-hydroxy-acid oxidizing enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CG723_44445</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CB01635</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the FMN-dependent alpha-hydroxy acid dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000047">
        <property type="protein sequence ID" value="PJN05497.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN05497">
        <property type="protein sequence ID" value="PJN05497"/>
        <property type="gene ID" value="CG723_44445"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02809">
        <property type="entry name" value="alpha_hydroxyacid_oxid_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012133">
        <property type="entry name" value="Alpha-hydoxy_acid_DH_FMN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000262">
        <property type="entry name" value="FMN-dep_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037396">
        <property type="entry name" value="FMN_HAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023989">
        <property type="entry name" value="MftD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01070">
        <property type="entry name" value="FMN_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000138">
        <property type="entry name" value="Al-hdrx_acd_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03966">
        <property type="entry name" value="actino_HemFlav"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51349">
        <property type="entry name" value="FMN_HYDROXY_ACID_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0288">FMN</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FMN hydroxy acid dehydrogenase" evidence="6">
        <location>
            <begin position="2"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="4">
        <location>
            <position position="279"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="81"/>
            <end position="83"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="109"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="129"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="131"/>
        </location>
        <ligand>
            <name>glyoxylate</name>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="157"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="166"/>
        </location>
        <ligand>
            <name>glyoxylate</name>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="255"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="277"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="279"/>
        </location>
        <ligand>
            <name>glyoxylate</name>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="310"/>
            <end position="314"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="333"/>
            <end position="334"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00024042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000138-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000138-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PJN05497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="393" mass="42153" checksum="393E44988507D04D" modified="2018-04-25" version="1">MGRNPWFETVAEAQRRAKKHLPSNVYDALVAGSERGRTIDDNLGAFAELGFAPRVAGHHAKRDLTTTVLGVETSMPVVISPTGVQAVDPDGEVAVARAAANRNVIMGLSSFASKPVEEVTAANSNTFYQMYWTGSREDMSQRMDRARTAGAKALIATLDWSFSNGRDWGSPEVPEAINFKTAVKLAPNVITRPRWLWSFVRSGRIPDLTTPNLQPPGGKAPTFFGAYYEWMQTPPPTWDDVKWMREEWGGPFLLKGVSRVDDARRAVDAGVSAISVSNHGGNNLDTTPATIRILPSIAEAVGDDIEVLLDGGIRRGGDVAKALALGARAVMIGRAYLWGLGANGQAGVENVLDLMRGGLDSAVLGLGRSSIRELCPDDLVIPDGFTRTLGAAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JFK5</accession>
    <name>A0A2M9JFK5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Antitoxin VapB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_43445</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000043">
        <property type="protein sequence ID" value="PJN05669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003955420.1">
        <property type="nucleotide sequence ID" value="NZ_NNBL01000043.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN05669">
        <property type="protein sequence ID" value="PJN05669"/>
        <property type="gene ID" value="CG723_43445"/>
    </dbReference>
    <dbReference type="GeneID" id="57806958"/>
    <dbReference type="GeneID" id="61470850"/>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014447">
        <property type="entry name" value="UCP006909"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006909">
        <property type="entry name" value="UCP006909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN05669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="98" mass="11222" checksum="3616BA32913140EE" modified="2018-04-25" version="1">MIFKRIGNGRPYPDHGRESTRQWADVAPRPVRLDQLVTTKGQLDLETLLAEDSTFYGDLFAHVVKWQGDLYLEDGLHRAVRAALQQRQVLHARVLELG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JFQ2</accession>
    <name>A0A2M9JFQ2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Extradiol ring-cleavage dioxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_43070</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000042">
        <property type="protein sequence ID" value="PJN05714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN05714">
        <property type="protein sequence ID" value="PJN05714"/>
        <property type="gene ID" value="CG723_43070"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004360">
        <property type="entry name" value="Glyas_Fos-R_dOase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00903">
        <property type="entry name" value="Glyoxalase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VOC" evidence="1">
        <location>
            <begin position="14"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="domain" description="VOC" evidence="1">
        <location>
            <begin position="145"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN05714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="314" mass="34283" checksum="52C293DC2F0B8689" modified="2018-04-25" version="1">MPHPSPGPVARLRSLRYVELLTPAFTEAADFYEEVWGLRTVEAERGAAAWLRGTGEEHHVLHLTRADRTGLGRLAFAVATPAEVDEAARRLEARGITPVFGPGPLDQVGGGYGLRFTDPERRLVEISAQVEAVAPRGRDAAVPVGVTHAVLNTADIDASVAFYCDVLGLRVSDWSEHQMAFLRCNADHHCIAFNQAEWASLNHVAYEMSSVDHFMRGLGRLKHHGIDPQWGPGRHGPGNNTFSYFTDPSGLVCEYTSEVAQIVEDAWIARVWRRVPELSDLWGTAGPPSKEIRCHMAGSPDPGPLASTSQEVPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JG41</accession>
    <name>A0A2M9JG41_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MarR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_42710</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000040">
        <property type="protein sequence ID" value="PJN05846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN05846">
        <property type="protein sequence ID" value="PJN05846"/>
        <property type="gene ID" value="CG723_42710"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000835">
        <property type="entry name" value="HTH_MarR-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019885">
        <property type="entry name" value="Tscrpt_reg_HTH_AsnC-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12802">
        <property type="entry name" value="MarR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00598">
        <property type="entry name" value="HTHMARR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00347">
        <property type="entry name" value="HTH_MARR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00519">
        <property type="entry name" value="HTH_ASNC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50995">
        <property type="entry name" value="HTH_MARR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH marR-type" evidence="1">
        <location>
            <begin position="30"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN05846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="182" mass="20202" checksum="D243B1BB11CC5208" modified="2018-04-25" version="1">MGDNPGDSEPTLDEQIAAYQREFQDLDPQVEQIVSALGRLNRRMNVAYGRQTANLGITNAEWEVLKALVLSGAPYRMGPGDLAKRLGLTPAAMTHRIDRMVGEGLVTRDRDESNRVRVIVELTTEGRAKWLEAMRLASGFEEDLLQDLSSDERGVLGEVLTRLLRRVEDAQPDAGGRLTDLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JGM3</accession>
    <name>A0A2M9JGM3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_41840</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000037">
        <property type="protein sequence ID" value="PJN05992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN05992">
        <property type="protein sequence ID" value="PJN05992"/>
        <property type="gene ID" value="CG723_41840"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002731">
        <property type="entry name" value="ATPase_BadF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01869">
        <property type="entry name" value="BcrAD_BadFG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BcrAD_BadFG" evidence="2">
        <location>
            <begin position="75"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN05992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="348" mass="34288" checksum="AD3BB310F21A2F88" modified="2018-04-25" version="1">MTRGPAATGPGGGGNPPAGPGWVLGVDSGGSGLRVALAAAGDLTRPETTVSREPVRTGAAGIDAGHLLAQILPMARELLARVGDRGPGVPRLSAVAVGAAGMATLGDGLRAELPDALAAELGVRRLALAADGVTAYAGALGQRPGAVVAAGTGMIALGTDLGTWRRADGWGHLLGDCGGGAWIGRAGLDAAMRAYDGRRGGSAALLALAEERFGPVAGLPARIYPRTDRPAVLASFAPDVARAALDDSVAAGILRAAAGHVAEAAAAVCPAGDGSEVALTGGLFKMGEPLLAPLRAELAEQLPYAEAVSATGDPLHGALVIAAALALDGLLLPRDGRLLHVPGEEAGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JGW4</accession>
    <name>A0A2M9JGW4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Amino acid permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CG723_41875</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CB01635</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000037">
        <property type="protein sequence ID" value="PJN05997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN05997">
        <property type="protein sequence ID" value="PJN05997"/>
        <property type="gene ID" value="CG723_41875"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="43"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="76"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="117"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="163"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="197"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="235"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="275"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="325"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="371"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="398"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="444"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="478"/>
            <end position="500"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PJN05997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="527" mass="56063" checksum="37BD17D77FC98BCA" modified="2018-04-25" version="1">MPDIPPDGPGHAASDHDASDHDEDAALTELGYKPELKRTLGNFHTFAAGISYISILTGTFQLFYFGVSFGGPAYWWSWPMVFIGQLMVALSFCELAARFPVAGSVYNWAKHTGGPHIGWLAGWMMTIATMVSLAAVALAYQLTLPQISSFFQVIGDGTGQYDAATNAVLLGTILILFTTLINAFGVKLMATINSAGVFIELIAAVVLVGLLAAHITRGPSAIVDTDGYGQGQPLGYLGAFLTASLASAYVMYGFDTASSLGEESKDPARNAPRAILRALIASFVLGGLILLFALLATPDLRAKELSVDGLQYVVKATLGETVGLAVLWCVVIAITVCALSVQTAGLRMAFAMARDNNLPAGSKLARISPRFKTPVVATCLIGIVAIAILVVNIKQPQIFSVVTSIAIIMIYIAYLLVTGPMLVQRLRGEWSPAPGYFSLGRLGLPVNILAVLWGAAMSVNLLWPRAAVYNATGPQHWYLRWGGVLFVSVVAAAGFAYYWFVQRKKTGVIAEHAVGEPPEPAPAHGRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JHF9</accession>
    <name>A0A2M9JHF9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Thioesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_39955</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the thioesterase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000032">
        <property type="protein sequence ID" value="PJN06319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN06319">
        <property type="protein sequence ID" value="PJN06319"/>
        <property type="gene ID" value="CG723_39955"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012223">
        <property type="entry name" value="TEII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001031">
        <property type="entry name" value="Thioesterase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11487">
        <property type="entry name" value="PTHR11487"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00975">
        <property type="entry name" value="Thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioesterase" evidence="2">
        <location>
            <begin position="6"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN06319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="243" mass="26879" checksum="122FB9D266EC1BDD" modified="2018-04-25" version="1">MQQPLRLFVFHHAGGSHLLYREWPAKLPAHWDVRLMDAPGRGRLTGEPPIDDAGELAAFFLRRLAADLTGPFAFFGHSMGALVAYEMTRRLAAEGRELPVWLGLSARGAPRPLGENTRRHALPDEELRLHLAAMGGTPVEVLRDPDLWEMFAPAIRNDLKLVESWRPLADTPALTMPVAVYGGMKDVVVPPERLAAWEQHAERFQGLRMSEGGHFYFQADPRPLLGLITRDATAALSAAVSPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-05-25" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JHR7</accession>
    <name>A0A2M9JHR7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">LacI family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CG723_39085</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000030">
        <property type="protein sequence ID" value="PJN06418.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN06418">
        <property type="protein sequence ID" value="PJN06418"/>
        <property type="gene ID" value="CG723_39085"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01392">
        <property type="entry name" value="HTH_LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000843">
        <property type="entry name" value="HTH_LacI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046335">
        <property type="entry name" value="LacI/GalR-like_sensor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00356">
        <property type="entry name" value="LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13377">
        <property type="entry name" value="Peripla_BP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00354">
        <property type="entry name" value="HTH_LACI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50932">
        <property type="entry name" value="HTH_LACI_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH lacI-type" evidence="4">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PJN06418.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="334" mass="35728" checksum="3F6C5C354C59E87C" modified="2018-04-25" version="1">MADVARVAGVSSQTVSRVSNGFPGVNEETRERVLAAMKDLGYRPNSAARALKRGDFRTIGVITFTLSTTGNMRTLEAIATSAAQEGYAVTLLPVAVPTQDEVRGAFSRLGELAVDAVIVIMEVHLLDSASLTLPPHVKVVVADSDADDRYAVVDTDQAGGTRDAVRHLLDLGHRTVWHLAGPSESFAAQRRTDAWRRALEAAGRAVPPLVRGDWSAGSGYRAGLRLAEQGDCTAVFAANDQMALGLLRALEERGRRVPEDVSVIGFDDIPDSGSFQPPLTTVHQDFAEVGRRCVESALRQVRQGEAEPGTTLVPTRLVVRESTGQPPSREGGRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JHX7</accession>
    <name>A0A2M9JHX7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MerR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_39340</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000030">
        <property type="protein sequence ID" value="PJN06452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN06452">
        <property type="protein sequence ID" value="PJN06452"/>
        <property type="gene ID" value="CG723_39340"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="SSF46955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN06452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="136" mass="15004" checksum="4AD35956DDBE8C06" modified="2018-04-25" version="1">MNHDPRRAAAAPEAGHRRSTAPDKQRPLNVVVHNYAIVPVDRLSLDVVARRSGLHPDLVRRFVTLGLVDATRDDSGRLWFDPGAPATLARIQRLRAGLPLNYASLGLVLDLLDRVSELEAALRRSNAGSRSDESWI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JHZ7</accession>
    <name>A0A2M9JHZ7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MerR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_38890</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000029">
        <property type="protein sequence ID" value="PJN06509.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN06509">
        <property type="protein sequence ID" value="PJN06509"/>
        <property type="gene ID" value="CG723_38890"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000551">
        <property type="entry name" value="MerR-type_HTH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13411">
        <property type="entry name" value="MerR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00040">
        <property type="entry name" value="HTHMERR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00422">
        <property type="entry name" value="HTH_MERR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="SSF46955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50937">
        <property type="entry name" value="HTH_MERR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH merR-type" evidence="1">
        <location>
            <begin position="8"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN06509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="304" mass="33583" checksum="82ACDA958C0F1880" modified="2018-04-25" version="1">MIDDGPRLLTIGQLSRRTGLSVRTIRYWSDVGALPPVGRSQGGYRLYDAQSLARLELIRTLRELGLGLDDVRRVVDGETDIASVAAAHVAALDAQIRSLRLNRAVLSTVAKRNSSAEEMALMNKLARLSAAERKHIIDDFMEQTFGGLDAADPDIRTRMRVMVPELPDDPTTEQVDAWVELAELMQDPDFRAHMRRMIEFNAADRGPDVPPGSSLWFMSRLVQLAGEARERGVAPESPEAEEVLRGLLGNADPAAVLERMEAAANNDVARFRDLVSLVRGLETLPRHNEEFAWVVAALRARTAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JI57</accession>
    <name>A0A2M9JI57_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CG723_38270</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000028">
        <property type="protein sequence ID" value="PJN06554.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN06554">
        <property type="protein sequence ID" value="PJN06554"/>
        <property type="gene ID" value="CG723_38270"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034660">
        <property type="entry name" value="DinB/YfiT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007061">
        <property type="entry name" value="DUF664"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04978">
        <property type="entry name" value="DUF664"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109854">
        <property type="entry name" value="SSF109854"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PJN06554.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="168" mass="18690" checksum="307358ED773B5BE5" modified="2018-04-25" version="1">MGIHVPYTGGEKESLLAALDRHRDVVLWKLQGLDEEQVRRPMAPSGNSLLGLVKHLASVEYGWFCETFGRPVEPLWFDPETDEDLRVGPEESTERITAFYGRARAASDAVIAEVGLEETGTSWDGKKVSMRWVLIHMLEETARHAGHIDILRELIDGAAGDHQGTSRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JIH0</accession>
    <name>A0A2M9JIH0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_38060</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000027">
        <property type="protein sequence ID" value="PJN06681.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN06681">
        <property type="protein sequence ID" value="PJN06681"/>
        <property type="gene ID" value="CG723_38060"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014773737" evidence="2">
        <location>
            <begin position="30"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="50"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="103"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="133"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="160"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="199"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="226"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="258"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN06681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="296" mass="30372" checksum="53AAD6BBB8B52F21" modified="2018-04-25" version="1">MSVLVLVLAVSAAFCLGIGFVLQQNAAQHAPLNDFLSPRLLLDLVRVPRWLGGIGFMVCGMALGAIALGNGEISLVEPLLATNLLFALALSRHQTRQPLGKQGWAGLALLAGGVTAFIVAGEPRSGDAVTDPLRRWLIIGVMVGGALLLTAYAKKSRMGAAPVLLGVAAGLLYGVQDALTRMSGQLFSSGGWAGLFTSWQPYGVLVLGVTGLILVQSAFEMAPLRMSLPALTAAQPLAGIACGVGFMGDQLRTDAGALAWQATGLTAIVSGIVLLGMHPAMPTAGPREGDRAGVGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-09-29" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JIN4</accession>
    <name>A0A2M9JIN4_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">PHB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CG723_37720</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CB01635</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the band 7/mec-2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000027">
        <property type="protein sequence ID" value="PJN06627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN06627">
        <property type="protein sequence ID" value="PJN06627"/>
        <property type="gene ID" value="CG723_37720"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.479.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043202">
        <property type="entry name" value="Band-7_stomatin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001107">
        <property type="entry name" value="Band_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036013">
        <property type="entry name" value="Band_7/SPFH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001972">
        <property type="entry name" value="Stomatin_HflK_HflKC_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10264">
        <property type="entry name" value="PTHR10264"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01145">
        <property type="entry name" value="Band_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00721">
        <property type="entry name" value="STOMATIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00244">
        <property type="entry name" value="PHB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117892">
        <property type="entry name" value="SSF117892"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PHB" evidence="3">
        <location>
            <begin position="23"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="255"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PJN06627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="279" mass="30484" checksum="85130FE2ED65AD9D" modified="2018-04-25" version="1">MVEELVVAGAAAASAAVICVTAAAARVVNQYERGVVFRLGRLRPDVRGPGFTMIVPFVDRLRKVNMQIVTMPVPAQDGITRDNVTVRVDAVIYFKVVDASEAVVQVEDYRFAVSQMAQTSLRSIIGKSDLDDLLSNREKLNQGLELMIDSPAIGWGVQIDRVEIKDVSLPETMKRSMSRQAEAERERRARIINADAELQASRKLAEAASEMSEQPAALQLRLLQTVVAVAAEKNSTLVLPFPVELLRFLERATPGDAARQPAAERPPIPGPAASESRQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JIS2</accession>
    <name>A0A2M9JIS2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Flavodoxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_37565</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000026">
        <property type="protein sequence ID" value="PJN06786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN06786">
        <property type="protein sequence ID" value="PJN06786"/>
        <property type="gene ID" value="CG723_37565"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005025">
        <property type="entry name" value="FMN_Rdtase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03358">
        <property type="entry name" value="FMN_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52218">
        <property type="entry name" value="SSF52218"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FMN_red" evidence="1">
        <location>
            <begin position="6"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN06786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="195" mass="21603" checksum="4520F50813A15756" modified="2018-04-25" version="1">MSRTFLFLLGSSRGEGNTEILARRAAEQLSPEVGQRWIDLAAHPLPDFEDLRHDSDHTRPAGDNTALLLDATLEATDIVIASPLYWYSVSAPTKRYLDYWSGWLRTPGIDFKATLQGRTLWGVTALAHEEQVVADPLVGTLRNSAAYMGMRFGGVLLGNGSKPGDVLKDEEALLRAKSFFAPERQPEIARFPYEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JJ16</accession>
    <name>A0A2M9JJ16_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_36895</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000025">
        <property type="protein sequence ID" value="PJN06861.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN06861">
        <property type="protein sequence ID" value="PJN06861"/>
        <property type="gene ID" value="CG723_36895"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="79"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="104"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN06861.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="140" mass="15501" checksum="0414EE37E820A9BF" modified="2018-04-25" version="1">MEARDAELKKELDATLHARRELGEEYESALVDSFLDKVEQRLDGAVDRRVRRQLAEQQMVVARGARSPRGDSDSWGERFGFGVVSLVLAIPLSAIAVVNADLPGLLIAWTGIVGVNALHAVRGMPRFGSRKERDSSDWED</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JJJ6</accession>
    <name>A0A2M9JJJ6_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Thymidylate kinase</fullName>
            <ecNumber evidence="3">2.7.4.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">dTMP kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">tmk</name>
        <name evidence="7" type="ORF">CG723_35440</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CB01635</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 3">
            <text>ATP + dTMP = ADP + dTDP</text>
            <dbReference type="Rhea" id="RHEA:13517"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58369"/>
            <dbReference type="ChEBI" id="CHEBI:63528"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.9"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 3">Belongs to the thymidylate kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.9" evidence="3"/>
    <dbReference type="EMBL" id="NNBL01000023">
        <property type="protein sequence ID" value="PJN07033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN07033">
        <property type="protein sequence ID" value="PJN07033"/>
        <property type="gene ID" value="CG723_35440"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004798">
        <property type="term" value="F:thymidylate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006233">
        <property type="term" value="P:dTDP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006235">
        <property type="term" value="P:dTTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00165">
        <property type="entry name" value="Thymidylate_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039430">
        <property type="entry name" value="Thymidylate_kin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018095">
        <property type="entry name" value="Thymidylate_kin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018094">
        <property type="entry name" value="Thymidylate_kinase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02223">
        <property type="entry name" value="Thymidylate_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00041">
        <property type="entry name" value="DTMP_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01331">
        <property type="entry name" value="THYMIDYLATE_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 7" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0545">Nucleotide biosynthesis</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="44"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="78"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="204"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="238"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="293"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="326"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="356"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="380"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="420"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="452"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="domain" description="Thymidylate_kin" evidence="6">
        <location>
            <begin position="514"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="761"/>
            <end position="1084"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="761"/>
            <end position="851"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="866"/>
            <end position="880"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1027"/>
            <end position="1050"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1060"/>
            <end position="1084"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="516"/>
            <end position="523"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PJN07033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="1084" mass="113160" checksum="E79173B92DD5C0DE" modified="2018-04-25" version="1">MTRAEQPTAQNPAPDDALVADSRERAVRALLRVPQLKRLWSAQLVGGIGDALGLLVLVVLALQTAVSEGSFGGGYRGVAFAVAAVFGARVLATLLFGAVLLGPLTSLTSADGPLDRRWTMVGADGVRAALLIVAPLWIDWTPDNALAVLLVTAFVVGVAERFWTVSRESAAPALLPAPPLEGAAVRPLPDHMDALRRLSLRTGFVALPVAAAALVAVTLVGNLIGAGVDWFGLHQAALASYVAAGLFAASLSVVFFLELPDTQTPRARSPLEGMRRPKTGSGVDKGRTGAIPLLVLACAAVAAAISAAVAVSVLHAKDLSGGPVTFGLLVLGLTGGTVIGIRSAPSVLPSLSRRRLLALAIALTGIALLAAGLVPDVTSVLLIVTLAGVTAGIAANTGHTLLDQESEDYRRARTTEHLQAVVRVSIAVAAVAAPLLAAAIGPHRLVNGKFVFAHGGAAFTLMLVGALLLPVAALVLAKADDRSGVPLRHDLRDALLGGNDPAQAPATTGFFIALEGGDGAGKSTQAEALAEWIRGKGHEVVVTREPGATPVGKRLRSILLDVSSAGLSHRAEALLYAADRAEHVDTVVRPALERGAVVISDRYIDSSVAYQGAGRDLSPTEVARINRWATGGLVPHLTVLLDVDPQAARERFTEAPDRLESEPAEFHARVRSGFLTLAAADPGRYLVVDAAQEPEAVTTVVRHRLDMVLPLSEAEVKAQEEARKAAVEEARRKAEAEAARKAEEERVERERLEQLAKLRAEEEERKQRELEEAQRREAERQAEEARQRAEESRRRAEEERARLLAEEQTRAAEEERRRRQAEEEARLRAEAEERRLEKQRKAEEALLRAEEARRLAAASAAAASAAAESASASSASAAGAGAGSASAAGHPVADNETTIPTPVMKPTGGAADETAVLPPVGDAGTGPGTGGAGSDAGPAAAARAGRGAWHGGDNDETTQLPVPPRPAQHQGGAADETAVLPPVRDDSVGSGAGGGPADRVPPGYFRDERQASAPSAGAGAGSNDRTRELPQVDEEGRPRQRPRPDWAEETPLDDLPSLADELLGGHDDAGEGDEGAGGRRRGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JJQ7</accession>
    <name>A0A2M9JJQ7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_35815</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000023">
        <property type="protein sequence ID" value="PJN07100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN07100">
        <property type="protein sequence ID" value="PJN07100"/>
        <property type="gene ID" value="CG723_35815"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN07100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="60" mass="6212" checksum="629197871CAFFF57" modified="2018-04-25" version="1">MDYVSALVPPVVMAVFFVGLIVTIVKSQGGDRKAKEDAAVDAAIARAEAARQAGPQPSDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JKG0</accession>
    <name>A0A2M9JKG0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_34445</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000021">
        <property type="protein sequence ID" value="PJN07352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN07352">
        <property type="protein sequence ID" value="PJN07352"/>
        <property type="gene ID" value="CG723_34445"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007313">
        <property type="entry name" value="FxsA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35335">
        <property type="entry name" value="PTHR35335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04186">
        <property type="entry name" value="FxsA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="21"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="44"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="100"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="164"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="168"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN07352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="193" mass="20587" checksum="2F6E5264BD160350" modified="2018-04-25" version="1">MTTGTPPPSRPATPRRSRVRTFLPLGIAAWLVLEIWLLTVVAGAAGGFTVFLLLLAGIVLGAVVIKRAGRRAFKNLSETLQQQQSGAVPAGEQRSGGNGLLMLAGLLLMIPGLISDALGLVLLVPPVRTALSRYTERTIERKMQSATPGTFGDAFQQARMHRPDGTVIQGEVIKDDERPAQRPDAGPRPPITP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JKM2</accession>
    <name>A0A2M9JKM2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_33445</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000020">
        <property type="protein sequence ID" value="PJN07413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN07413">
        <property type="protein sequence ID" value="PJN07413"/>
        <property type="gene ID" value="CG723_33445"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014844882" evidence="2">
        <location>
            <begin position="26"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="22"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="47"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="75"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="102"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="117"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN07413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="269" mass="27268" checksum="6A27946F4E0C1A10" modified="2018-04-25" version="1">MFCPIATVITTTACLTALAPGSVSAHEPVTAPASVTAPGEVGRTDSVGRTDLLRRADSDDGTRDQGSSDGTRDQGSSDGTRDRGSYDGTRDQGLPDGTRDQGLPDGTRDRGSVDGTRDRGSSNGDSYAEARLSPSTVGAASSVEITVSCRGGGRSSITARSQAFAAGSVTLPQLGGGIGQDGRTQYRGTARLSGVVGTSSQVNVQGACPDGRQWSTPMNVTRDGYRGARAGVGSTAGGGVDLGRIGFGAALAGGAGYLLWRRTRAPHED</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JKV0</accession>
    <name>A0A2M9JKV0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Monooxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_33995</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000020">
        <property type="protein sequence ID" value="PJN07499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN07499">
        <property type="protein sequence ID" value="PJN07499"/>
        <property type="gene ID" value="CG723_33995"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018580">
        <property type="term" value="F:nitronate monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04730">
        <property type="entry name" value="NPD_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004136">
        <property type="entry name" value="NMO"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03060">
        <property type="entry name" value="NMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NMO" evidence="1">
        <location>
            <begin position="13"/>
            <end position="355"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN07499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="375" mass="39677" checksum="3FD9D68E59838C3C" modified="2018-04-25" version="1">MQTELSKKLGIEHAIFGFTPFPAVAAAISRAGGFGVLGAVRYTAPDDLARDLDWMQEHVDGAPYGLDVVMPAKKVEGPNHQKLTEADVEAMIPEGHRQFVRDTLAKHGVPELAEGEASGWRITGWMEQVARSQLDVAFDYPIKLLANALGSPPADVVQRAHDHDVLVAALAGSARHARKHADAGIDIVVAQGYEAGGHTGEIASMVLTPEAVDAVAPLPVLAAGGIGSGEQIAAALALGAQGVWLGSLWLTTTEADLHSRALTAKLLAAGSGDTVRSRALTGKPARQLRTEWTDAWDDPTGPGTLPMPLQGLLVAEAVSRIQKHEVDRLLGTPVGQIVGRMTSERPVQAVFDDLTRGFERAVDRINRIAGRSGQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JN01</accession>
    <name>A0A2M9JN01_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA helicase</fullName>
            <ecNumber evidence="3">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CG723_29995</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">CB01635</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O = ADP + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the helicase family. UvrD subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="3"/>
    <dbReference type="EMBL" id="NNBL01000015">
        <property type="protein sequence ID" value="PJN08234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08234">
        <property type="protein sequence ID" value="PJN08234"/>
        <property type="gene ID" value="CG723_29995"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004527">
        <property type="term" value="F:exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.320.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013986">
        <property type="entry name" value="DExx_box_DNA_helicase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014017">
        <property type="entry name" value="DNA_helicase_UvrD-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000212">
        <property type="entry name" value="DNA_helicase_UvrD/REP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011604">
        <property type="entry name" value="PDDEXK-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038726">
        <property type="entry name" value="PDDEXK_AddAB-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014016">
        <property type="entry name" value="UvrD-like_ATP-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11070">
        <property type="entry name" value="PTHR11070"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12705">
        <property type="entry name" value="PDDEXK_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00580">
        <property type="entry name" value="UvrD-helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13361">
        <property type="entry name" value="UvrD_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51198">
        <property type="entry name" value="UVRD_HELICASE_ATP_BIND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51217">
        <property type="entry name" value="UVRD_HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0227">DNA damage</keyword>
    <keyword evidence="9" id="KW-0234">DNA repair</keyword>
    <keyword evidence="7" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="10 14" id="KW-0347">Helicase</keyword>
    <keyword evidence="10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UvrD-like helicase ATP-binding" evidence="12">
        <location>
            <begin position="17"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="domain" description="UvrD-like helicase C-terminal" evidence="13">
        <location>
            <begin position="345"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="832"/>
            <end position="994"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1197"/>
            <end position="1237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="11">
        <location>
            <begin position="956"/>
            <end position="984"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1198"/>
            <end position="1237"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="38"/>
            <end position="45"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="PJN08234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="1237" mass="134647" checksum="7718B9C29C1EC8A7" modified="2018-04-25" version="1">MTTRLTDPEQLKELLGIPFTPEQTACITAPPAPQVIVAGAGSGKTTVMAARVVWLVGTGQVAPEQVLGLTFTNKAAGELAERVRKALIKAGVTDPDAIDPDNPPGEPVISTYHAFAGRLLTDHGLRIGLEPTARLLADATRFQLAARVLREAPGPYPALTRSFADLVSDLLTLDGELAEHLVHPDELRAYDTRLLHALEGRKLTNADLRKVPEAAAARLDLTGLVTRYREAKRARDLLDFGDQIALSATLARTRPEVGAILRDEFRVVLLDEYQDTSVAQRILLAGLFGAGTGHPVTAVGDPCQAIYGWRGASVANLDDFPEHFAHADGRPATRLSLSENRRSGGRLLDLANGLAQPLRALHAGVEALRPAPGAERDGIVRCALLRTHAEEIDWLGDSLAHLVRTGTAPGEIAVLCRTATDFAAIQGALVARDIPVEVVGLSGLLHLPEVADLVAVCEVLQDPGANASLVRLLTGPRWRIGPRDLALLGRRARLLVAHARGGPDDDPDRRLAEAVEGVDPSEVISLADALDTFLETPLDEPGDDKLPFSPQARVRFARLATELRDLRRSLADPLMDVLHRVLAVTGLEVELAASPHALAARRRETLSNFLDIAASFAANDSSATLLAFLGFLRTAAQYEKGLDNALPGGENTVKVLTAHKSKGLEWDVVAVPGLVTGTFPSAQGREKWTAQSKVLPHELRGDAATLPDIEAWDSKGMKAFHEEMKEHQRTEELRLGYVTYTRPRTLLLGSGHWWGPAQKRPRGPSDFLQALYDHCAAGHGEIEAWADEPAEDEENPALQEAAAEHAWPLPLDDEAMARRRAAAATVLAHLETPADDHSHEMAHPATYTDPDWPAPPDEEALHEDEPFYEDAPLNEEGDFFSSPEDGPGPDWDEWDDWDALPHERPTLPHPTGTPAHEQPAADAPHNDAHPRPDDARPTPAPVYGAPHAPDDAHPLGAIPHPTPPQDADPRPHPDPAPTKTAPPERPPLTAEETRTLASWDRDLDALTGELLRSRQAVRDVPLPTTLTASQLLRLAADPDGFAQDLARPMPRPPQPAARRGTRFHAWVESRFEELRLPMLDPEELPGSEADIADEHDLDTLKEAFDRTPYAHRTPHRVETPFQLAIAGRVIRGRIDAVYKEGDGDDTTYEIVDWKTTRGRTADPLQLAVYRLAWAEQHGLPPEAVKATFVYVRDGETVTPRDLPGRAEMERLLLEDPTPGPRDRTAPEPPHEHTPADG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-05-25" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JN35</accession>
    <name>A0A2M9JN35_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Adenylyltransferase/sulfurtransferase MoeZ</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CG723_29965</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000015">
        <property type="protein sequence ID" value="PJN08269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08269">
        <property type="protein sequence ID" value="PJN08269"/>
        <property type="gene ID" value="CG723_29965"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008641">
        <property type="term" value="F:ubiquitin-like modifier activating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045886">
        <property type="entry name" value="ThiF/MoeB/HesA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000594">
        <property type="entry name" value="ThiF_NAD_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035985">
        <property type="entry name" value="Ubiquitin-activating_enz"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953">
        <property type="entry name" value="PTHR10953"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00581">
        <property type="entry name" value="Rhodanese"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00899">
        <property type="entry name" value="ThiF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00450">
        <property type="entry name" value="RHOD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69572">
        <property type="entry name" value="SSF69572"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Rhodanese" evidence="4">
        <location>
            <begin position="300"/>
            <end position="390"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PJN08269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="392" mass="42468" checksum="CAEF37D29E37D87F" modified="2018-04-25" version="1">MSLPPLVEPAAELTVDEVRRYSRHLIIPDVGMDGQKRLKNAKVLAVGAGGLGSPALMYLAAAGVGTLGIVEFDEVDESNLQRQIIHSQADIGRSKAESAKDSVLGINPYVNVILHEERLEAENVMDIFSQYDLIVDGTDNFATRYLVNDACVLLNKPYVWGSIYRFDGQASVFWSEHGPCYRCLYPEPPPPGMVPSCAEGGVLGVLCASIGSIQVTEAIKVLAGVGEPLVGRLMIYDALEMQYRQVKVRKDPDCAVCGPNATVTELIDYEAFCGVVSEEAQEAAAGSTITPKQLKEWIDDGENIEIIDVREPNEYEIVSIPGARLIPKNEFLMGTALESLPQDKKIVLHCKTGVRSAEVLAVLKSAGFADAVHVGGGVIGWVNQIEPEKPVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-09-29" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JN38</accession>
    <name>A0A2M9JN38_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_28115</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000014">
        <property type="protein sequence ID" value="PJN08274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08274">
        <property type="protein sequence ID" value="PJN08274"/>
        <property type="gene ID" value="CG723_28115"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002586">
        <property type="entry name" value="CobQ/CobB/MinD/ParA_Nub-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01656">
        <property type="entry name" value="CbiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CbiA" evidence="1">
        <location>
            <begin position="10"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN08274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="329" mass="35632" checksum="4E0B7C9D50AED17D" modified="2018-04-25" version="1">MVNMKIAFVGKGGSGKTTLSSLFVRHLAAMGAPVIAVDADINQHLGPALGLDDDQAAELPAMGARLPLIKDYLRGSNPRIASADTMIKTTPPGEGSRLLRVRENNPVYDACARPVELDGGAVRLMVTGPFTEADLGVSCYHSKTGAVELCLNHLVDGRDEYVVVDMTAGSDSFASGMFTRFDMTFLVAEPTRKGVSVYRQYKEYARDFGITLKVVGNKVQGQDDLDFLRAQVGDDLLVTVGHSDWVRAMEKGRPPRFDLLEEPNAAALRTLRSAADAAYAGRDWERYTRQMVHFHLKNAQSWGNAKTGADLAAQVDPAFVLQESVAATA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JN96</accession>
    <name>A0A2M9JN96_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CG723_28490</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CB01635</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 3">Belongs to the DedA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000014">
        <property type="protein sequence ID" value="PJN08330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08330">
        <property type="protein sequence ID" value="PJN08330"/>
        <property type="gene ID" value="CG723_28490"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032818">
        <property type="entry name" value="DedA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032816">
        <property type="entry name" value="SNARE_assoc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30353">
        <property type="entry name" value="PTHR30353"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09335">
        <property type="entry name" value="SNARE_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="20"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="74"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="154"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="187"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU367016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PJN08330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="225" mass="23279" checksum="356D0191ADDAAD72" modified="2018-04-25" version="1">MAVDPLAAAQAVNVLDAGSLLSAFGALGVAVVLFAETGLLVGFFLPGDSLLFTAGLLCAGGSHGPVHLSLPQVLAAAVVGALVGAQAGYWIGRRGGRALLARSRAKRLHEGAARAEELLDRYGHAKAIVLARFVPVVRTVLNPLAGALGVPARVFTVWQVVGGLVWTVGLVLAGYGLGSSVPNVDRYLLPIVALVVIVSLIPLALEVWRSRARSRDRRAAEEGTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JNJ7</accession>
    <name>A0A2M9JNJ7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Alkyl hydroperoxide reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_29125</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000014">
        <property type="protein sequence ID" value="PJN08438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08438">
        <property type="protein sequence ID" value="PJN08438"/>
        <property type="gene ID" value="CG723_29125"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016209">
        <property type="term" value="F:antioxidant activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14951">
        <property type="entry name" value="NHL-2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000866">
        <property type="entry name" value="AhpC/TSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045302">
        <property type="entry name" value="NHL2_NHL_rpt_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001258">
        <property type="entry name" value="NHL_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00578">
        <property type="entry name" value="AhpC-TSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01436">
        <property type="entry name" value="NHL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Thioredoxin" evidence="2">
        <location>
            <begin position="1"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN08438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="601" mass="64414" checksum="1F807289EC3091E3" modified="2018-04-25" version="1">MNDVDPAPRRARVRAPELIGKGGWLNTGGKQYTLADLRGRIVILDFWTFCCVNCLHVLDELRELEEKHRDTVVIVGVHSPKFVHEAEHSAVVDAVERYNVEHPVLDDPELATWKQYAVRAWPTLAVIDPEGYVVAQHAGEGHAHAIEKLVEQLEAEHGAKGTLRRGDGPYVAPEPVATDLRFPGKVLVLPSGNFLVSDTTRHQLVELAADGESVVRRIGSPGEFNEPQGLALLDDATVVVADTVHHSLKAVDLASGDVTTLAGTGRQWWQGAPTSGPALEVSLSSPWDVAVFGGKVWIAMAGVHQLWTYDPETKSVAVAAGTTNEGLVDGPGAEAWFAQPSGLAATEERLWVADSETSALRYVDLDGTVHTAVGTGLFDFGHRDGAAEQALFQHPLGVTALPDGSVAVSDTYNHALRRYDPASGEVTTLATDLREPSDAVLVGGDSPDIVVVESARHRLTRLRLPEEAVRVESVAHRTQRAATEVAAGKLQLDVIFQAPAGQKLDTRYGPSTRLLVSSTPPELLVAGDGADTDLARELVLNTEVAEGVLHVSAMAASCDDDPANEYPACHVHQQDWGVPVRLTEGGADRLPLVLAGMDDRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JNM7</accession>
    <name>A0A2M9JNM7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">1,2-phenylacetyl-CoA epoxidase subunit A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_29300</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000014">
        <property type="protein sequence ID" value="PJN08469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08469">
        <property type="protein sequence ID" value="PJN08469"/>
        <property type="gene ID" value="CG723_29300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097266">
        <property type="term" value="F:phenylacetyl-CoA 1,2-epoxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010124">
        <property type="term" value="P:phenylacetate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012347">
        <property type="entry name" value="Ferritin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009078">
        <property type="entry name" value="Ferritin-like_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011881">
        <property type="entry name" value="PaaA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007814">
        <property type="entry name" value="PaaA_PaaC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05138">
        <property type="entry name" value="PaaA_PaaC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47240">
        <property type="entry name" value="SSF47240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02156">
        <property type="entry name" value="PA_CoA_Oxy1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="330"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN08469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="354" mass="39099" checksum="055ED48270D57EAD" modified="2018-04-25" version="1">MATAAAHQAARTQAAHATSDATGTASGQASGTAAYQTAFDTAVAAEERIEPRDWMPDAYRATLVRQIAQHAHSEIIGMQPEANWITRAPSLRRKAILMAKVQDEAGHGLYLYSAAETLGTGRDELLDKLHSGRQKYSSIFNYPTLTWADVGAIGWLVDGAAITNQVPLCRCSYGPYARAMVRICKEESFHQRQGYELLLALSRGTEAQHAMAQDAVDRWWWPSLMMFGPPDDESSHSAQSMEWKIKRHSNDELRQRFVDICVPQAESLGLTLPDPDLVWNEERGHHDFGAIDWTEFWEVLKGNGPCNEQRITQRRQAHDEGAWVREAAAAHAAKHSEAKHSGAQDSGANGKATA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JNQ0</accession>
    <name>A0A2M9JNQ0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_28525</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000014">
        <property type="protein sequence ID" value="PJN08490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08490">
        <property type="protein sequence ID" value="PJN08490"/>
        <property type="gene ID" value="CG723_28525"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="47"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="70"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="249"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="71"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="109"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="257"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="303"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN08490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="332" mass="32260" checksum="958AE5A9CCCD1595" modified="2018-04-25" version="1">MDSLGSDELALRRLLHEAVEEIEPTNGTLEHLRRAVPARRARKRQAVVGMAAAALFIGTAIPALVHVAGQSGSNDRPSIAGNSEATRGGTGSGKGPDGGESGTGSPSGKSKSKDKDGKKDKPGDKGKGAGGGATGGPDPASTAAASSPVCGAADLGGAPANVGAADAGGRVYGSFRVTNISQANCSVDAPGTVSVMAQGAADPAKVNVVDHTAGDAATGLPDPSTEPSQLILEPGMSYEVRFAWVPSAECPTTGGGGDPSPSPTPSGGTTGDATGSNPDQSGLSTQLVAEGPTADGSVAVSHTAEGGTPSSSATIPNACSGTVYRTGILPAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JP39</accession>
    <name>A0A2M9JP39_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CG723_26375</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000012">
        <property type="protein sequence ID" value="PJN08630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08630">
        <property type="protein sequence ID" value="PJN08630"/>
        <property type="gene ID" value="CG723_26375"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045649">
        <property type="entry name" value="DUF6400"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19938">
        <property type="entry name" value="DUF6400"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PJN08630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="83" mass="8949" checksum="40F3D56B650D87FE" modified="2018-04-25" version="1">MNQDNSPGLIPFTIDLTFEEARRRAEVVAALGPDWDPAAVLRGEDEAHALLYSGLDAEQQRTYDLLVAAGVLPGEESGRASSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JP40</accession>
    <name>A0A2M9JP40_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Formyltetrahydrofolate deformylase</fullName>
            <ecNumber evidence="3">3.5.1.10</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Formyl-FH(4) hydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3 5" type="primary">purU</name>
        <name evidence="5" type="ORF">CG723_26425</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CB01635</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the hydrolysis of 10-formyltetrahydrofolate (formyl-FH4) to formate and tetrahydrofolate (FH4).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>(6S)-10-formyltetrahydrofolate + H2O = (6S)-5,6,7,8-tetrahydrofolate + formate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19833"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="ChEBI" id="CHEBI:57454"/>
            <dbReference type="EC" id="3.5.1.10"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Purine metabolism; IMP biosynthesis via de novo pathway; formate from 10-formyl-5,6,7,8-tetrahydrofolate: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the PurU family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.10" evidence="3"/>
    <dbReference type="EMBL" id="NNBL01000012">
        <property type="protein sequence ID" value="PJN08639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08639">
        <property type="protein sequence ID" value="PJN08639"/>
        <property type="gene ID" value="CG723_26425"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00170"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008864">
        <property type="term" value="F:formyltetrahydrofolate deformylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016742">
        <property type="term" value="F:hydroxymethyl-, formyl- and related transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006730">
        <property type="term" value="P:one-carbon metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04875">
        <property type="entry name" value="ACT_F4HF-DF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd08648">
        <property type="entry name" value="FMT_core_Formyl-FH4-Hydrolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01927">
        <property type="entry name" value="PurU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002912">
        <property type="entry name" value="ACT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041729">
        <property type="entry name" value="Formyl-FH4-Hydrolase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002376">
        <property type="entry name" value="Formyl_transf_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036477">
        <property type="entry name" value="Formyl_transf_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004810">
        <property type="entry name" value="PurU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044074">
        <property type="entry name" value="PurU_ACT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42706">
        <property type="entry name" value="PTHR42706"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01842">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00551">
        <property type="entry name" value="Formyl_trans_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01575">
        <property type="entry name" value="FFH4HYDRLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53328">
        <property type="entry name" value="SSF53328"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="SSF55021"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00655">
        <property type="entry name" value="PurU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51671">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 3" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="3" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ACT" evidence="4">
        <location>
            <begin position="17"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PJN08639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="294" mass="32606" checksum="4AAD3A2E67405F0C" modified="2018-04-25" version="1">MNEQSPASGVAGGEQYVLTLSCPDKRGIVHAVSSYLFMTGCNIEDSQQFGDHDTGLFFMRVHFSADAPVTAEKLRASFAAVGDSFHMDWQIHRSAERMRVVLMVSKFGHCLNDLLFRASIGALPVDIAAVVSNHTDFAELVKSYDIPFHHIPVTKDNKPEAEAQILDLVRAEDVELVVLARYMQVLSDDLCKELSGRIINIHHSFLPSFKGAKPYHQAHTRGVKLIGATAHYVTAALDEGPIIEQEVERVGHDVTPDQLVAIGRDVECQALARAVKWHAERRILLNGRRTVVFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-06-02" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JP48</accession>
    <name>A0A2M9JP48_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_26430</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000012">
        <property type="protein sequence ID" value="PJN08640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08640">
        <property type="protein sequence ID" value="PJN08640"/>
        <property type="gene ID" value="CG723_26430"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN08640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="166" mass="18619" checksum="3E57247EAFCEDFCB" modified="2018-04-25" version="1">MTVQSSENSSRRGRRSSTMGGMPLNDMPWWRWRSNVRSALHMLSDPAFQRDVWLAGVDGFGDVTDAVYRLVEDTWLDNWSAEKYVGTIFRDSQEAQLVDTAVLRVLRIMHQVGPDAPVSAYLDHHAWPEAVQSARVAHVVLATSDGDDPDAAPRTLEVLRIMTRAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JP91</accession>
    <name>A0A2M9JP91_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Short-chain dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CG723_26715</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000012">
        <property type="protein sequence ID" value="PJN08691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08691">
        <property type="protein sequence ID" value="PJN08691"/>
        <property type="gene ID" value="CG723_26715"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PJN08691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="259" mass="26936" checksum="6126403285A565E1" modified="2018-04-25" version="1">MGKLDGRVVVITGAARGQGEQEARLFAAEGAKVVLGDVLDDQGEALAKEIGGLYVHLDVSREDDWAAAVVAAKKAYGKIDGLVNNAGILRFNELVSTPLDEFQQIIQVNQVGAFLGIKTVAPEIEAAGGGSIVNTASYTGVTGMAYVGAYTATKHAIVGLTKVAALELAAKKIRVNAVCPGAIDTAMSNPSQLDPGADTEEASQALDELYRKLVPLGRVGQPEEVARLALFLTAQEDSAYITGQPFVIDGGWLAGVSVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JPT1</accession>
    <name>A0A2M9JPT1_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">ATP synthase epsilon chain</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">ATP synthase F1 sector epsilon subunit</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">F-ATPase epsilon subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7 11" type="primary">atpC</name>
        <name evidence="11" type="ORF">CG723_25635</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CB01635</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Produces ATP from ADP in the presence of a proton gradient across the membrane.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7 8">F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Cell membrane</location>
            <topology evidence="1 7">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7 8">Belongs to the ATPase epsilon chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000011">
        <property type="protein sequence ID" value="PJN08878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08878">
        <property type="protein sequence ID" value="PJN08878"/>
        <property type="gene ID" value="CG723_25635"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045261">
        <property type="term" value="C:proton-transporting ATP synthase complex, catalytic core F(1)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd12152">
        <property type="entry name" value="F1-ATPase_delta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00530">
        <property type="entry name" value="ATP_synth_epsil_bac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001469">
        <property type="entry name" value="ATP_synth_F1_dsu/esu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020546">
        <property type="entry name" value="ATP_synth_F1_dsu/esu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036771">
        <property type="entry name" value="ATPsynth_dsu/esu_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13822">
        <property type="entry name" value="PTHR13822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02823">
        <property type="entry name" value="ATP-synt_DE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51344">
        <property type="entry name" value="SSF51344"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01216">
        <property type="entry name" value="ATP_synt_epsi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="7" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7 8" id="KW-0139">CF(1)</keyword>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="4 7 8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7 8" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ATP-synt_DE_N" evidence="10">
        <location>
            <begin position="5"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="76"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PJN08878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="124" mass="12988" checksum="4013383B5AD51B28" modified="2018-04-25" version="1">MAAELHVELVAADRSVWSGEATLVVARTASGDIGVMPGHQPLLGVLESGPVMIRTSDGGTVVAAVHGGFVSFADNKLSLLAEIAELSDEIDVQRAERALERAQADADASAERRADVRLRAVATR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JQK5</accession>
    <name>A0A2M9JQK5_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Aminopeptidase N</fullName>
            <ecNumber evidence="4">3.4.11.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CG723_24890</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">CB01635</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Release of an N-terminal amino acid, Xaa-|-Yaa- from a peptide, amide or arylamide. Xaa is preferably Ala, but may be most amino acids including Pro (slow action). When a terminal hydrophobic residue is followed by a prolyl residue, the two may be released as an intact Xaa-Pro dipeptide.</text>
            <dbReference type="EC" id="3.4.11.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the peptidase M1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.11.2" evidence="4"/>
    <dbReference type="EMBL" id="NNBL01000010">
        <property type="protein sequence ID" value="PJN09151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN09151">
        <property type="protein sequence ID" value="PJN09151"/>
        <property type="gene ID" value="CG723_24890"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1730">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045357">
        <property type="entry name" value="Aminopeptidase_N-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042097">
        <property type="entry name" value="Aminopeptidase_N-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001930">
        <property type="entry name" value="Peptidase_M1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014782">
        <property type="entry name" value="Peptidase_M1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027268">
        <property type="entry name" value="Peptidase_M4/M1_CTD_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01433">
        <property type="entry name" value="Peptidase_M1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17900">
        <property type="entry name" value="Peptidase_M1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00756">
        <property type="entry name" value="ALADIPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63737">
        <property type="entry name" value="SSF63737"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="6" id="KW-0645">Protease</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0732">Signal</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015006589" description="Aminopeptidase N" evidence="11">
        <location>
            <begin position="34"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M1_N" evidence="13">
        <location>
            <begin position="52"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M1" evidence="12">
        <location>
            <begin position="310"/>
            <end position="451"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012564"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00015611"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF17900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="PJN09151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="461" mass="49890" checksum="0F1DEB6D92EF901C" modified="2018-04-25" version="1">MPRSPRSAPAHALALVLALGACSAAGVHGTPGAAGVRDPYFPKLGNGGYDATHYDLTLDADRHRLTGTADITAKATQDLSAFNLDLKGLTVDGVTVDGRKARFERAGHELTIRPAEALRKGSTFRTVVRYSGKPVTITDPDGSEEGWLPTQDGVLALGEPTGSMAWFPGNNHPSDKASYDLHVTVPKGLKAVSNGELTKERTAGGRTTFDWHVPQPMAGYLAMLAIGKFETKAYKTPDGLPVYTAVDPVEAAASAKVLAKIPAVMAWESKTFGPYPFSSTGAVVDRHGDAGYALETQNRPVFPGTPPLSTLVHEMAHEWYGDSVTPESWRDMWLNEGFATYAEWLWAEQHGGDSAQKTFDSYYAKGSGNPIWAFPPARPSSAAHISDPPVYERGAMVLHKIRETVGDAKFFELLKSWPAAHRYGNADTADFTGYVEKQNPGKDLQPVWDDWLYGKGKPDHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JQR8</accession>
    <name>A0A2M9JQR8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GNAT family N-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_25215</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000010">
        <property type="protein sequence ID" value="PJN09211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN09211">
        <property type="protein sequence ID" value="PJN09211"/>
        <property type="gene ID" value="CG723_25215"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN09211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="165" mass="17602" checksum="788FB57A893CF8C4" modified="2018-04-25" version="1">MEIRKGSAADIPAIVGLFDGAMEWLVSQGRTGQWGERPWSERPRAVAMVEEYVAGGVPWIAETDGIPVGTLTLSEGPGSYVEPAGEPERYVHLLAARHGSGAGAALLAHAVQETRRAGIPLLRVDCYAGDDGKLVAFYEANGFVRTESFTGPDGVWPGQVLARRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JQS2</accession>
    <name>A0A2M9JQS2_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SGNH_hydro domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_25230</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000010">
        <property type="protein sequence ID" value="PJN09214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN09214">
        <property type="protein sequence ID" value="PJN09214"/>
        <property type="gene ID" value="CG723_25230"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013830">
        <property type="entry name" value="SGNH_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13472">
        <property type="entry name" value="Lipase_GDSL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SGNH_hydro" evidence="1">
        <location>
            <begin position="6"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN09214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="230" mass="24802" checksum="E47D3FB4F3AEA7A8" modified="2018-04-25" version="1">MLRFTFVGDSMTIGSAGELTWRYRMWQHLRAAYGDGAFEIAGPRETLHDKTANAPVSHDYADADPAFPRNHLAGWGEGWLHMAPVIEEAVALARTDVLLISLGLIDLGFYTNAEQTAQNVRRFVAGARAANPRVRMVLLPVIPNVRAETDAPFAAEVAHFNTLLAKAVADLDSGPSPLLLASVPESYDIHQDTYDGTHPNASGERKLADTFALAMRQAWGPVGASPGGLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JQU4</accession>
    <name>A0A2M9JQU4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_24565</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000010">
        <property type="protein sequence ID" value="PJN09238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN09238">
        <property type="protein sequence ID" value="PJN09238"/>
        <property type="gene ID" value="CG723_24565"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019662">
        <property type="entry name" value="DUF2516"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10724">
        <property type="entry name" value="DUF2516"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="46"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="87"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN09238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="113" mass="12053" checksum="45AF899CC31563B3" modified="2018-04-25" version="1">MLMSAFGGLMWLLYTAMLVLAVVALVMAAFSREDAFRAADKQNKMFWLIILGIAVAVNLLIPMLFLQLAGLVATIVFFVDVRPALQQVSGGGRGRRGGGSSSDGPYGPYNGGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JQW5</accession>
    <name>A0A2M9JQW5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="16">PTS alpha-glucoside transporter subunit IIA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">CG723_25035</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">CB01635</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000010">
        <property type="protein sequence ID" value="PJN09177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN09177">
        <property type="protein sequence ID" value="PJN09177"/>
        <property type="gene ID" value="CG723_25035"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008982">
        <property type="term" value="F:protein-N(PI)-phosphohistidine-sugar phosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009401">
        <property type="term" value="P:phosphoenolpyruvate-dependent sugar phosphotransferase system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00212">
        <property type="entry name" value="PTS_IIB_glc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036878">
        <property type="entry name" value="Glu_permease_IIB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018113">
        <property type="entry name" value="PTrfase_EIIB_Cys"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003352">
        <property type="entry name" value="PTS_EIIC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013013">
        <property type="entry name" value="PTS_EIIC_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001996">
        <property type="entry name" value="PTS_IIB_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00367">
        <property type="entry name" value="PTS_EIIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02378">
        <property type="entry name" value="PTS_EIIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55604">
        <property type="entry name" value="SSF55604"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51098">
        <property type="entry name" value="PTS_EIIB_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01035">
        <property type="entry name" value="PTS_EIIB_TYPE_1_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51103">
        <property type="entry name" value="PTS_EIIC_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0418">Kinase</keyword>
    <keyword evidence="10 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0598">Phosphotransferase system</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="130"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="163"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="187"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="218"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="256"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="286"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="328"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="390"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="440"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="domain" description="PTS EIIB type-1" evidence="14">
        <location>
            <begin position="7"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="domain" description="PTS EIIC type-1" evidence="15">
        <location>
            <begin position="125"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="478"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="active site" description="Phosphocysteine intermediate; for EIIB activity" evidence="11">
        <location>
            <position position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00421"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="PJN09177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="503" mass="51461" checksum="0233E800F20B43AF" modified="2018-04-25" version="1">MADSKNRAIAAAILPLVGGASNVTSVAHCMTRLRLGLADRALVDDDALKALPDVMGVVDDETYQIVLGPGKVARVTPEFEELVQDGKTAAPEPHAVTADELAAQGAELKAARKAKNATPFKLFLRRIANIFVPLIPALIGCGIIAGINGLLINLHWLPGVTPALAAIASGFMALIAVFVGYNAAKEFGGTPILGGAVAAIIVYAGVANIEAFGQKLSPGQGGVLGALGAAVLATYIEKWCRKWVPEAVDVLVTPTLTVLVSGLVTIFGLMFVAGEISTGIGTAANWLLDNTGAFAGLILGGLFLPLVMLGLHQALIPIHTTLIEQQGYTVLLPVLAMAGAGQVGCAIAVFKRLKHNKSIRTTIKSALPAGFLGVGEPLIYGVSLPLGRPFITACVGGAAGGAFVGFFSMIGDKVGSTAIGPSGWALFPLLDGNKGLGTTVAIYGAGLLVGYIVGFVATYFFGFSKQMLVDLNVDSPAAAAGESPAPAPAGTTEPKEPKEPAKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-09-29" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JR42</accession>
    <name>A0A2M9JR42_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CG723_23485</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CB01635</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000009">
        <property type="protein sequence ID" value="PJN09312.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN09312">
        <property type="protein sequence ID" value="PJN09312"/>
        <property type="gene ID" value="CG723_23485"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="36"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="61"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="93"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="118"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="159"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="191"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="243"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="278"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="309"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="334"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="374"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="403"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="21"/>
            <end position="425"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PJN09312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="461" mass="48664" checksum="BCB852DB011F7F0D" modified="2018-04-25" version="1">MSTSTPAGRQSALGSKDRFKTAIAAAFGTSVENYDFIAYGTASALYFGAVFFPGSDRFVGTLLSFATLAVGFVMRPLGGAIGGYFADKFGRKPVLVAAMTVMGAATFLIGALPTYEQVGVLAPILLVAIRMIQGLAFGAEWGGAITMAYEHAPWHRRGMFAAIPQSGNPLGIALASGVFAWSDTLDGNWQWRTPFLLSAILVIVALIVRSRLSESPEFQEAQASGETKKNPLRATLADDWQGILRVIALRVVESFAYYSTATYLLSYITERHPDLRPVALGAITAASLLAIAVTFLAGALTDRIGRRPIYIAACVAAILFAFPMYLLTNSARPALVVTVFIIGIGLIHASLTGTQGSLLTEQFRTATRTSGASLGYQIAAAIGGFAPLLAAALVGAFGWPGAALLYLGAAVIGLVGILATKETWGRHERERVLRLVAEQGHGQTTSGVSVNADLSSSSEFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JRC0</accession>
    <name>A0A2M9JRC0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_23695</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000009">
        <property type="protein sequence ID" value="PJN09431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN09431">
        <property type="protein sequence ID" value="PJN09431"/>
        <property type="gene ID" value="CG723_23695"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023485">
        <property type="entry name" value="Ptyr_pPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036196">
        <property type="entry name" value="Ptyr_pPase_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01451">
        <property type="entry name" value="LMWPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00226">
        <property type="entry name" value="LMWPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52788">
        <property type="entry name" value="SSF52788"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LMWPc" evidence="1">
        <location>
            <begin position="80"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN09431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="211" mass="21900" checksum="80B1009EA160D482" modified="2018-04-25" version="1">MSPSPVLPDERLAAGAARLATSHRGRFSAETVQRVITDSYERLAATARVTTHLVVLAERLTAERLDALAHIEGSPGSGLPRVLFACGHNAGRSQLAAALLAHRAQGHVTVSSAGTHPAAAVEPTVAQVLTEAGVPSGETAFPKPLTDEVVQAADIVITMGCGDACPVVADRRYLDWPVADPEGAPIAVVRTIRDAIDAPITELLDSLPSTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JRC7</accession>
    <name>A0A2M9JRC7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CG723_24105</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000009">
        <property type="protein sequence ID" value="PJN09408.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN09408">
        <property type="protein sequence ID" value="PJN09408"/>
        <property type="gene ID" value="CG723_24105"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PJN09408.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="115" mass="11750" checksum="AEA9A2F8A2BED22E" modified="2018-04-25" version="1">MPGLILHSGATMTCAHQGSANPPAPAQQRVLVGSQPVATTADTFVVLGCAFPAASLGAPPCTSIRWTQMSTRVLVNRLPVLLQPTPPPSFGAGVGVGTPPSPPMVQAMQLRVRGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-09-29" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JRS5</accession>
    <name>A0A2M9JRS5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CG723_22875</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CB01635</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000008">
        <property type="protein sequence ID" value="PJN09581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN09581">
        <property type="protein sequence ID" value="PJN09581"/>
        <property type="gene ID" value="CG723_22875"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="23"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="61"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="93"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="117"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="151"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="186"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="252"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="285"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="318"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="343"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="375"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="409"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="27"/>
            <end position="433"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PJN09581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="435" mass="47442" checksum="00085DF4983F1667" modified="2018-04-25" version="1">MPTTVPTAESPELTRENAVFRKVIRRIVPFLILCYVVSYLDRVNVGFAKLQMSEDLGFSEAAYGLGAGLFFIGYFLFEVPSNLMLQKVGARTWIARIMISWGVVSALFVFVNNEATFYVLRFLLGAAEAGFYPGVILYCTYWFPSARRARVIALFMSAIPVAGIFGNPLSGWIMDVFEGTGGWNGWQWLFLIEALPAIAVGVMTLFYLDNSVREAKWLSDDEKSTIERALAEDTKHQSEHGKTWDAFRDPKVWLMCLIYFFFVMGQYALTFWMPTFVESTGIEGGFAIGALSAVPYLAALVAMNLFGRSADKRRERRWHLVIPSLMGAVGFSLAASWTGSTALSLVALSIAAAGVLTCAPLFWSLPTAFLSGTAAAAGLAVINSVGNLAGFVSPYMIGSLKDATDSTAIPMYVLALGLVIGAAAVLVTKKSVVNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-09-29" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JS65</accession>
    <name>A0A2M9JS65_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CG723_21170</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CB01635</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000007">
        <property type="protein sequence ID" value="PJN09716.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN09716">
        <property type="protein sequence ID" value="PJN09716"/>
        <property type="gene ID" value="CG723_21170"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="21"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="59"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="90"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="115"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="148"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="190"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="275"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="313"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="341"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="375"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="413"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="444"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="7">
        <location>
            <begin position="24"/>
            <end position="466"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PJN09716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="474" mass="50561" checksum="875298BBAAB3EECA" modified="2018-04-25" version="1">MTSTAKPPSAREAHPDHLGHVIFITAAAAMGGFLFGYDSSVINGAVEAIRDRYDIGSGTLAQVIAIALIGCAIGAATAGRIADRIGRIRCMQIAAVLFTISAVGSALPFALWDLAFWRIVGGFGIGMASVIGPAYIAEVSPPAYRGRLGSFQQAAIVVGIAISQLVNYGILQAAGGDQRGQVLGLEAWQVMLGVMVIPAVLYGMLSFAIPESPRFLISVGKEARAKEILAEVEGTKIDLDARVTEIEHAMKSEHKSTFKDLLSGKGNGGLYFKPIVWIGIGLSVFQQFVGINVAFYYSSTLWQSVGVNPTDSFFYSFTTSIINIIGTVIAMLLVDRVGRKPLALVGSVGMVIGLALEAWAFSYDLVDGKLPATQGWVALIAAHFFVLFFALSWGVVVWVFLGEMFPNKIRAAALGVAASAQWIANWAITASFPSLADWNLSGTYVIYTIFAALSIPFVLKFVKETKGKALEEMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-09-29" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JSB1</accession>
    <name>A0A2M9JSB1_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Signal peptidase I</fullName>
            <ecNumber evidence="4">3.4.21.89</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">lepB</name>
        <name evidence="7" type="ORF">CG723_21305</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CB01635</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>Cleavage of hydrophobic, N-terminal signal or leader sequences from secreted and periplasmic proteins.</text>
            <dbReference type="EC" id="3.4.21.89"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Membrane</location>
            <topology evidence="4">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the peptidase S26 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.89" evidence="4"/>
    <dbReference type="EMBL" id="NNBL01000007">
        <property type="protein sequence ID" value="PJN09742.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN09742">
        <property type="protein sequence ID" value="PJN09742"/>
        <property type="gene ID" value="CG723_21305"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006465">
        <property type="term" value="P:signal peptide processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06530">
        <property type="entry name" value="S26_SPase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036286">
        <property type="entry name" value="LexA/Signal_pep-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000223">
        <property type="entry name" value="Pept_S26A_signal_pept_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019756">
        <property type="entry name" value="Pept_S26A_signal_pept_1_Ser-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019533">
        <property type="entry name" value="Peptidase_S26"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43390">
        <property type="entry name" value="PTHR43390"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10502">
        <property type="entry name" value="Peptidase_S26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00727">
        <property type="entry name" value="LEADERPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51306">
        <property type="entry name" value="SSF51306"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02227">
        <property type="entry name" value="sigpep_I_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00501">
        <property type="entry name" value="SPASE_I_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 4" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="43"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_S26" evidence="6">
        <location>
            <begin position="45"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="71"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR600223-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU362042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF10502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PJN09742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="232" mass="24968" checksum="E693E8BA340C33D5" modified="2018-04-25" version="1">MDTEAQTTERDRASQPSVHEGEEERSRFAFVPWAASWLPGGRLTLSALLCLVLLLLLSIFVMQPFQIPSGSMEPALRVGDRVLVNKLAYRFGAEPQRGDVVVFDGTGYFGDADYIKRVVGVGGDHVVCCDSKGRIGVNGEPVDESSFLYPGNTPSKVPFDLVVPDGTLFLLGDHRGDSRDSRDYLGAPGGGMVPVGEVIGRAQWIAWPTGHWGSLSRNDVYARVPGPGGAHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-06-02" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JSI3</accession>
    <name>A0A2M9JSI3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_21710</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000007">
        <property type="protein sequence ID" value="PJN09813.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN09813">
        <property type="protein sequence ID" value="PJN09813"/>
        <property type="gene ID" value="CG723_21710"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN09813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="274" mass="28467" checksum="5BB7DA5E3642FA65" modified="2018-04-25" version="1">MMAMTSSPPAGAGSSWDGNSWNGNGNANGSPGGAPSPAAGDRSRTGFGLFGPRHQRHTLSVEQLDTLALPIGDDGVVVGVDADGQPAVLGVNRPTPYDMVLIGGLWTAQVLALRAAATGARVAVETGRAQAWAQLVQAVGGGQSGMTVHDVGRVPPQGASAGGPVLVVRDCGMRPPRGRVASAPWQSVLTLLPYLSPVAPRLMRQARLVGVQRVSPDEAAEIGRVIGLPRGEWESLPTLADGVTLWCTDRDRQYVMTRATDAETGLLGNARRMD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JSW0</accession>
    <name>A0A2M9JSW0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_19760</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000006">
        <property type="protein sequence ID" value="PJN09966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN09966">
        <property type="protein sequence ID" value="PJN09966"/>
        <property type="gene ID" value="CG723_19760"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014915960" evidence="1">
        <location>
            <begin position="30"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN09966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="171" mass="18191" checksum="BF05E29B8102B8ED" modified="2018-04-25" version="1">MRINKAVATVGAVAALFAGSTLAATTASAQPDFHAQSVASGLSDAQATSLQKRVDKVLAGHAGGRQVSPTEVRYDGLNVKVSPTGTFSEAALNCGYGHLCMTVNGTNFDFYKCQRWNVHNWTGDGPFINNQTPGTVAKFYNKDGSVRWTSTAYQSGRATWDPIWSLQPCGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JTJ3</accession>
    <name>A0A2M9JTJ3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Siderophore-interacting protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CG723_19655</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CB01635</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000006">
        <property type="protein sequence ID" value="PJN10142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN10142">
        <property type="protein sequence ID" value="PJN10142"/>
        <property type="gene ID" value="CG723_19655"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050896">
        <property type="term" value="P:response to stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039425">
        <property type="entry name" value="RNA_pol_sigma-70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013249">
        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43133">
        <property type="entry name" value="PTHR43133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08281">
        <property type="entry name" value="Sigma70_r4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="5">
        <location>
            <begin position="25"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4_2" evidence="6">
        <location>
            <begin position="117"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PJN10142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="187" mass="20747" checksum="195964AB41E7B8DB" modified="2018-04-25" version="1">MIARVRAGDVEAYAVLVRAFTGLALRAARALGAGADAEDVVQQAFFKAYRALGQFRDDSSFKPWLLAIVANETRNTVRSAVRQRSVVGREATLIEAEPLIPETTDPAVAAVHDERRTALLAALEELSEEHRLVVTYRYLLEMDEAETAEALGWPRGTVKSRLNRALRKLKRILPAELDPREGGDEHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-09-29" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JTZ3</accession>
    <name>A0A2M9JTZ3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Nitrate reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CG723_18385</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CB01635</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the purine-cytosine permease (2.A.39) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000005">
        <property type="protein sequence ID" value="PJN10344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN10344">
        <property type="protein sequence ID" value="PJN10344"/>
        <property type="gene ID" value="CG723_18385"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001248">
        <property type="entry name" value="Pur-cyt_permease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026030">
        <property type="entry name" value="Pur-cyt_permease_Fcy2/21/22"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31806">
        <property type="entry name" value="PTHR31806"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02133">
        <property type="entry name" value="Transp_cyt_pur"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002744">
        <property type="entry name" value="Pur-cyt_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="44"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="74"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="118"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="154"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="182"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="220"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="259"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="303"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="339"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="367"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="408"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="450"/>
            <end position="466"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR002744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PJN10344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="482" mass="50044" checksum="BF91490A79C0B836" modified="2018-04-25" version="1">MAPTIPDPTTQAAAPPADRAGRVEAHGIDFIPDAERHGRARELFAVWAAPNVSYLSLVVGGALILMGLGLWQALGVIAAGNLCWVLVGLVAVSGPAAGTPSQVITRAMFGVRGNRANIALTGWFVSVCYLALSWAAASLSAFSLVDKAGFELTTGVKVVVIVVLAAATLAISVYGHATIVKLYLPFSLALTAVFVVLAGYVLGHVDWGYAPPHPLHGTELWSVVIGGITLVASAPLSYSNSADFARYLPRTTSPTAIAGWTTLGAYVPSVLFTSLGALAGTALDMSDPQTALEGILPSWFKPAFLLAVILGAICNNAMTAYSSGLALQSIGVRIRRSRSVALDGALGVALTLYALLVSNFLDTVNNVLELMVALMGPSIAIYATDILWRRNRYDGRELTDESRGSAFWYSGGVNWAGVTALVVATAVASQCVNTPMYTGPIARAAGGTDLSLPVGILVSAAVYVAMMRSRRPAAGGPTPTSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JU82</accession>
    <name>A0A2M9JU82_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MarR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_18970</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ROK (NagC/XylR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000005">
        <property type="protein sequence ID" value="PJN10440.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN10440">
        <property type="protein sequence ID" value="PJN10440"/>
        <property type="gene ID" value="CG723_18970"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000600">
        <property type="entry name" value="ROK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18964">
        <property type="entry name" value="PTHR18964"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00480">
        <property type="entry name" value="ROK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN10440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="384" mass="40339" checksum="AD3C1C63D3C9101D" modified="2018-04-25" version="1">MSARTASWLPLSPGERAVAIEVLTHGPLSRSEIAKRLSLSPGSLTRLTKPLIESGLLVEEATTAASLRQGRPSQPLDIVAGSQSFAGFKITGDAVYGVVTTLRSEIVARRSEPLDTHDPEEIADLLHRMTTGFQENFPRLAGIGIGVGGNVRHRATVVANAFLGWEEVPLAEMVEERTGLPVVVDSDVAALIEAEAWFGAGRGLDRFAVLTIGAGIGYGLVLGGRLVRTGEDGHGVGKRWIINANGPLTPEGERGSAMALLTIPSICYQVRAATGRNVTYEEILAGAASGDPLCSRVIDEAARALGTLVAQIANFAMPEKILLAGEGVGLADVAGGTVHETILANRHPKADPVHLETKVSDFHEWARGAAVLAIQVLVLGTNEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JUB8</accession>
    <name>A0A2M9JUB8_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">YCII domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_17590</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the YciI family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000005">
        <property type="protein sequence ID" value="PJN10480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN10480">
        <property type="protein sequence ID" value="PJN10480"/>
        <property type="gene ID" value="CG723_17590"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005545">
        <property type="entry name" value="YCII"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03795">
        <property type="entry name" value="YCII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YCII" evidence="2">
        <location>
            <begin position="1"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007689"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN10480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="182" mass="20232" checksum="46005543501845E1" modified="2018-04-25" version="1">MEFFCYHRDRLDSLALRHELLEDHWSYMDQYGKELIARGPTFSSDGEEPTGSVHIVDLPDTAAARAFAFDEPGYQAGVYRDVMLRRWHNKLGRTMWEYPGGAAEGNRYLVLGLGAGHTADLDVPSDQDDLIAYGPLLSDDGATWLGTAALVRAPDPDTACAVLTVGLYAEIEVHDWQFGGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JUS2</accession>
    <name>A0A2M9JUS2_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF1998 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_15565</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000004">
        <property type="protein sequence ID" value="PJN10630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN10630">
        <property type="protein sequence ID" value="PJN10630"/>
        <property type="gene ID" value="CG723_15565"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018973">
        <property type="entry name" value="MZB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09369">
        <property type="entry name" value="DUF1998"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF1998" evidence="1">
        <location>
            <begin position="487"/>
            <end position="584"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF09369"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN10630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="621" mass="67786" checksum="6DAED86C0E69F8F4" modified="2018-04-25" version="1">MTPPPARRRRTGGNGSTPVLNLRRRGAVRRAQAITTYGVGAMIAVDQESFIVSGLDDAEEHWNRDESPRIHEQRLSRLLGVGHFRLPPASDESSRDGLRVRRFPVMHSCPECKDLQRHQAFNSPAGRSVCGTCEVDLVPSRFVVACEAGHIDEFPYWHWVHRSSERGGGSGATAGSCGGTLKMRSSGRSLSLRSVLVSCTCGVPEVSMEGSFRKNALKDLGLRCRGTRPWLGTSVPAQSCAETARTIQRGSSSAWQPVLKSALSIPPWSDGRADPLADRWPLLRKLEGRAAIEGFLYGAFPDGPPVSVDEVMELLEAEREEDPQDEGTPTFEHRYQALRNKEYERLRAGNDDRERSRDEQFVCEPPVGDPKLLNPLGVTGPMLVKKLREVRALKAFTRLAEPESASEAYEAALSASGLNWLPAMEVRGEGVFFRLDEARLAAWEAATAARVQRMRSAHQKLLEQSAKDPGHVPTSPATPRMVLLHTLAHVLINEWSLDAGYPAAALRERLYADEHMAGVLIYTATSDSAGSLGGLVAQGEPERLADTLHSAVRRAEWCSSDPLCIESRRSGTGGTNLAACHACVMLPETSCEHNNILLDRALLVGTPDAPSIGFFTGLLDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JV82</accession>
    <name>A0A2M9JV82_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Acyl-CoA synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_16325</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000004">
        <property type="protein sequence ID" value="PJN10752.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN10752">
        <property type="protein sequence ID" value="PJN10752"/>
        <property type="gene ID" value="CG723_16325"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039543">
        <property type="entry name" value="POX18/UbiT/NSL-TP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003033">
        <property type="entry name" value="SCP2_sterol-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036527">
        <property type="entry name" value="SCP2_sterol-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10094">
        <property type="entry name" value="PTHR10094"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02036">
        <property type="entry name" value="SCP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55718">
        <property type="entry name" value="SSF55718"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SCP2" evidence="1">
        <location>
            <begin position="54"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN10752.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="159" mass="17204" checksum="6BC31AB846DB2D70" modified="2018-04-25" version="1">MGEGTGTRDGIADLDFSAVTPEQFAKIVKGLSAKEIDEIARDGELRARILKEVFARMERQFKPETAGSLQALIRWKVTSAGDQEAAVYETAIADGTCTVTEGRSDATPRVTLAMGDADFLKLVSGNQSPVMMFMMRKVKITGDAALAAGLNRYFDIPKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JVC1</accession>
    <name>A0A2M9JVC1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">TetR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_16570</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000004">
        <property type="protein sequence ID" value="PJN10792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN10792">
        <property type="protein sequence ID" value="PJN10792"/>
        <property type="gene ID" value="CG723_16570"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041678">
        <property type="entry name" value="TetR_C_16"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17920">
        <property type="entry name" value="TetR_C_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="12"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="35"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN10792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="190" mass="21001" checksum="6C4872A5402DC45A" modified="2018-04-25" version="1">MTGTTQQARRSDATRTAILAAARERFAADGYERATIRAIAKDAAIDPSMVMRYYGNKEGLFAAAIDLDLRLPDPEEIAVDDIGRTLVRHFLDLWEENEVLTALLRVGVTNTAGAERMQDIFRKQTLPLALRVCADPAEAPVRAALCASQVLGLALTRYVLRFGPAVGLSRDEMVEWLAPTLQRYLTAERP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-05-25" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JVE1</accession>
    <name>A0A2M9JVE1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Rod shape-determining protein MreD</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">mreD</name>
        <name evidence="9" type="ORF">CG723_16820</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CB01635</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MreD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000004">
        <property type="protein sequence ID" value="PJN10834.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN10834">
        <property type="protein sequence ID" value="PJN10834"/>
        <property type="gene ID" value="CG723_16820"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007227">
        <property type="entry name" value="Cell_shape_determining_MreD"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03426">
        <property type="entry name" value="shape_MreD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0133">Cell shape</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="36"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="74"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="103"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="139"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PJN10834.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="224" mass="22891" checksum="E041AB8C4B3FD0E7" modified="2018-04-25" version="1">MRFNRLLLSAPLVIVALVVQVCVLARLQLPGAVPDLVLLTVVGLALVYGHVGGAFIGFGAGLLADLAPPADHAAGRYALVLCVVGYLVGLAKPDNGQLRSAFGPMVVVVAAAVGSTLLYAVVGALVGDTAARHVGIGSLLFTAALYDLLLAPFTVPFIIALARRAENDPLADSSPGAGKATDVTAGWLSSGTGLRIGNQRGGLRLKTARARTARAGRIKGVKRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JVI8</accession>
    <name>A0A2M9JVI8_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Gamma-glutamyl phosphate reductase</fullName>
            <shortName evidence="7">GPR</shortName>
            <ecNumber evidence="7">1.2.1.41</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Glutamate-5-semialdehyde dehydrogenase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Glutamyl-gamma-semialdehyde dehydrogenase</fullName>
            <shortName evidence="7">GSA dehydrogenase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">proA</name>
        <name evidence="9" type="ORF">CG723_16900</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CB01635</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>L-glutamate 5-semialdehyde + NADP(+) + phosphate = H(+) + L-glutamyl 5-phosphate + NADPH</text>
            <dbReference type="Rhea" id="RHEA:19541"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58066"/>
            <dbReference type="ChEBI" id="CHEBI:58274"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.2.1.41"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 7">Amino-acid biosynthesis; L-proline biosynthesis; L-glutamate 5-semialdehyde from L-glutamate: step 2/2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the gamma-glutamyl phosphate reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.41" evidence="7"/>
    <dbReference type="EMBL" id="NNBL01000004">
        <property type="protein sequence ID" value="PJN10848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN10848">
        <property type="protein sequence ID" value="PJN10848"/>
        <property type="gene ID" value="CG723_16900"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00098">
        <property type="reaction ID" value="UER00360"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004350">
        <property type="term" value="F:glutamate-5-semialdehyde dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055129">
        <property type="term" value="P:L-proline biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd07079">
        <property type="entry name" value="ALDH_F18-19_ProA-GPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00412">
        <property type="entry name" value="ProA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020593">
        <property type="entry name" value="G-glutamylP_reductase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012134">
        <property type="entry name" value="Glu-5-SA_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000965">
        <property type="entry name" value="GPR_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000151">
        <property type="entry name" value="GPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="SSF53720"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00407">
        <property type="entry name" value="proA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01223">
        <property type="entry name" value="PROA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 7" id="KW-0521">NADP</keyword>
    <keyword evidence="6 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4 7" id="KW-0641">Proline biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldedh" evidence="8">
        <location>
            <begin position="13"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022650"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00412"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PJN10848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="427" mass="44875" checksum="A964362E77830E69" modified="2018-04-25" version="1">MTSLSPYDSMTPVTQAAYRARSAAGVIAPLPRAAKDDALAAIADALEVRTAEIVEANAKDIARAREAGTSESVIDRLTLTPERVRAIAADVRDVVALPDPVGTVVRGNTLPNGIDLRQVRVPLGVVGIIYEARPNVTVDAAALCLKSGNAVLLRGSSSAYESNTALVRVLRDAVGGSGLPADAIQLVPGESRDSVNELMRARGLVDVLIPRGGASLIKNVVENSIVPVIETGTGNCHVYVDAHADLDMAVDILINSKAQRPSVCNAAETLLVHQDIADAFVPRALAALAEAGVTVHADERVLAYAEGSKATVVEATPEDWETEYLSYDIAAAVVHSLDAAVEHIRLWSSGHTEAIVTTSQQAARRFTQLVDSTTVAVNASTRFTDGGQFGFGAEIGISTQKLHARGPMGLPELTSTKYIVTGDGHTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JVQ3</accession>
    <name>A0A2M9JVQ3_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Isoprenyl transferase</fullName>
            <ecNumber evidence="2">2.5.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CG723_17260</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CB01635</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="2">Binds 2 magnesium ions per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UPP synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.-" evidence="2"/>
    <dbReference type="EMBL" id="NNBL01000004">
        <property type="protein sequence ID" value="PJN10908.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN10908">
        <property type="protein sequence ID" value="PJN10908"/>
        <property type="gene ID" value="CG723_17260"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004659">
        <property type="term" value="F:prenyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00475">
        <property type="entry name" value="Cis_IPPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01139">
        <property type="entry name" value="ISPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001441">
        <property type="entry name" value="UPP_synth-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018520">
        <property type="entry name" value="UPP_synth-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036424">
        <property type="entry name" value="UPP_synth-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10291">
        <property type="entry name" value="PTHR10291"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01255">
        <property type="entry name" value="Prenyltransf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64005">
        <property type="entry name" value="SSF64005"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00055">
        <property type="entry name" value="uppS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01066">
        <property type="entry name" value="UPP_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2 4" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="2">
        <location>
            <begin position="44"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="2">
        <location>
            <begin position="88"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="2">
        <location>
            <begin position="217"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="43"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="2">
        <location>
            <position position="91"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="43"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="48"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="56"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="60"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="92"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="94"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="211"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="230"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PJN10908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="273" mass="31347" checksum="9BC62416443CCD3D" modified="2018-04-25" version="1">MARRGILGRSRREYKTPEPHPTGARPPKIPGELVPEHVAIVMDGNGRWAKERGLPRTEGHKVGAERVMDVLQGAIEMGVGAISLYAFSTENWKRSPDEVRFLMNFNRDFIRKTRDQLDELGVRVRWVGRMPKLWKSVAQELEISQEQTKGNDKLTLYFCMNYGGRAEIADAAQAIAEDVKAGRLDPSKVSEKTFAKYLYYPDMPDVDLFLRPSGEQRTSNYLLWQSAYAEMVFQDVLWPDFDRRDLWRACLEYASRDRRFGGAIPNEEQIANS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JW46</accession>
    <name>A0A2M9JW46_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_09090</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN11111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN11111">
        <property type="protein sequence ID" value="PJN11111"/>
        <property type="gene ID" value="CG723_09090"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN11111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="220" mass="23939" checksum="4C4ACBBD1E30FBD4" modified="2018-04-25" version="1">MGAMAPHVRTLGDPRTDPWQENLTMTATTGATQSAHPERPGRSDGVCSEFTVFTKIKPGHADALREDLAAMADAAADENVHAAVRQIGTLHDARHVIFDNDSRFMFASVFDGSWDTYIDDFAQTVVGARFDKVFSHCEGFPGVTDPGAKDWFVAQQEPAGVFVSAYPDLTVQQIYKDQRVDDAFQAVLDTAEFRAMLDNPANAALVGTPAFQKLLEEASA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JWU1</accession>
    <name>A0A2M9JWU1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Arylsulfatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CG723_10580</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CB01635</strain>
        </source>
    </reference>
    <comment type="PTM">
        <text evidence="3">The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the sulfatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN11363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN11363">
        <property type="protein sequence ID" value="PJN11363"/>
        <property type="gene ID" value="CG723_10580"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008484">
        <property type="term" value="F:sulfuric ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024607">
        <property type="entry name" value="Sulfatase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000917">
        <property type="entry name" value="Sulfatase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00884">
        <property type="entry name" value="Sulfatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="SSF53649"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00149">
        <property type="entry name" value="SULFATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sulfatase" evidence="4">
        <location>
            <begin position="4"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="modified residue" description="3-oxoalanine (Cys)" evidence="3">
        <location>
            <position position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR600917-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PJN11363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="495" mass="56305" checksum="1124B77627A7E101" modified="2018-04-25" version="1">MRQPNVVLICVDQWRGDCLSAAGHPDVHTPHLDELAGEGVRFDRAYSATPTCVPARVALFTGQSQERHGRVGYREGVPFEQVHPVTLPGEFRRGGYQTQAVGKMHVFPERARLGFDDVRLHDGYLHHARRRHSRNFEFFDDYVPWLRRQPGMTPAADYADHGVSCNSIVARPWDKPEALHPTTWAVTEAIEWLPRRDPTKPFFLYLSFHRPHHPYDPPEWAFDQYMALDPYEPVVGDWVDHYAPYRKDGFHEAAVGVIDPRLVHRARAGYYGHMAHIDLQIKRFREALVEAGLGDDTMFCFVSDHGEMMGDHHMFRKALGFEGSARVPILMNLAPSMRGGAGGSVADEVVELRDVMPTLLEAAGLPVPDSVDGRSLLPFLRGERPDDWREYLHGEHTYLGQSLQWVTDGRHKYLWMSGDGHEQLFDLAEDPRELVNLARRPEHAALLEHWRGRLIDALRDREEGFVDDGDLVTGRPVVTELRHTRERIAAATGVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JXF2</accession>
    <name>A0A2M9JXF2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Zn-dependent hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_11440</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN11508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN11508">
        <property type="protein sequence ID" value="PJN11508"/>
        <property type="gene ID" value="CG723_11440"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lactamase_B" evidence="1">
        <location>
            <begin position="25"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN11508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="210" mass="22091" checksum="DC5166F9121978EB" modified="2018-04-25" version="1">MAGARIEHLVTSGTFSLDGGTWDVDNNVWLVGDDSEVVVIDAAHDADAIAEAVGDRRLVAIVCTHAHDDHIDAAPALAERTGAPILLHPADTELWKQKHPDRTPDGELADGQQLAVAGVELTVLHTPGHCQGAVSLYAPELGAVFTGDTLFAGGPGATGRSFSDFPTIVESIRERLLTLPPETVVRTGHGDGTTIGAEAPHLEEWIARGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JXI8</accession>
    <name>A0A2M9JXI8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Toxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_11680</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AHA1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN11552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN11552">
        <property type="protein sequence ID" value="PJN11552"/>
        <property type="gene ID" value="CG723_11680"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013538">
        <property type="entry name" value="Activator_of_Hsp90_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08327">
        <property type="entry name" value="AHSA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN11552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="180" mass="19616" checksum="0D0CB93B69C7EB0C" modified="2018-04-25" version="1">MTTPHPGPTGSYAPFDDGRPAIRFTRTYDHAIERVWRYVTDPAELAHWFPSQVEIELRAGGVIRFHGDPNMPESTGRVLAVDAPRHLSFSWGGDELRFDLEALDAGRTRFTLTNVLEAADTAARNAAGWEVCLTALDAADRGESFDGPHAGTLAPWKIHYDAYVEAGLPSGAPVPGMDEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JXL4</accession>
    <name>A0A2M9JXL4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PucR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_12125</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN11624.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN11624">
        <property type="protein sequence ID" value="PJN11624"/>
        <property type="gene ID" value="CG723_12125"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2840">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025736">
        <property type="entry name" value="PucR_C-HTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042070">
        <property type="entry name" value="PucR_C-HTH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13556">
        <property type="entry name" value="HTH_30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH_30" evidence="1">
        <location>
            <begin position="331"/>
            <end position="389"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN11624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="399" mass="43657" checksum="DD4E98601B7A6996" modified="2018-04-25" version="1">MNSEPILFPPPDPRVTELARGCLEDIDSLVGLWVECVRPVRASYADRVSEEDFRATAWQAFEYLLRKVACLPLPERIATVSEEIGERRARQGVPLDSLLAAARLDFRVVWAALVDKAGEKDKAELVTSAYHVWEAVEKHVTGIMTAYQRTILDMGRRAADERRMWFARLLDSEGRNPTVVRDAALALGFQPDDRFLCAVAPPQHGAGLRRAATALRTAETPVQLQEVASDLVLAVQLGRRTTAETVLALLQETPCGVASAPAGLAAVPRAVVLATATARVLPVDAAGPRRLEDSWLDVLVQRAEGFGRDLADDVLSGLDAEAVPVGETKRLLDTVRSHLAGTGSVADTAAALYCHRNTIQQRINRFAELTGRDVRRPEDAALVALALRARDQHEKDHRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JXT2</accession>
    <name>A0A2M9JXT2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Fatty-acid--CoA ligase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_12290</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN11652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN11652">
        <property type="protein sequence ID" value="PJN11652"/>
        <property type="gene ID" value="CG723_12290"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-binding" evidence="1">
        <location>
            <begin position="27"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding_C" evidence="2">
        <location>
            <begin position="476"/>
            <end position="555"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN11652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="568" mass="59860" checksum="2BEF19595F0EA93B" modified="2018-04-25" version="1">MTTTWPTGMPRTLDYPDGTIADLLAGSAHAYPDRAALIDGDERLTYAELYERALRVAQGLRDQGIAPGDAVAVHIPNSIWFTVGYYGILFAGASVVPVNPAQPSIALRRQLDDSGTVAVLTHPSVAAQLAEGIVGSETVRLVSVAPPTAAAPTPGGDRAPVTFPVPTVAFDDLMKAEAAPPTAVEGDAIAHLAFTGGTTGVPKAVMVLHRNLVKNVLQVACWRSAAVPVVDEEGRITLSHVGEARTEHHIPVGSATGISIAPLFHGMGMVSQSVFAAAGLTMVVFGRFDPVRYLDTAERLGVHAITGSPALCHALLAVPGVRERDLSCVRLVSSGSAPINPAATAELANVFPRAIVSDGYGLTEATMGVSISPLDSAMPRPTGSTGLALFDTEIEIRDMDGVTPMARGEKGEVWVRGPQITAGYLGHPELTAGQYVDGWLRTGDLGTYDEQGWLSLVGRAKDMLIYKGYNVYPGPLENILREHPAVAQASVVGRPHPEHGEIPLAFVSLKSEAGGVDPTATAEELMAYVAERVAPYQRIRDVVIVDELPLSATGKILKTELRRRASGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JXX2</accession>
    <name>A0A2M9JXX2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Deoxyxylulose-5-phosphate synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CG723_12685</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN11714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN11714">
        <property type="protein sequence ID" value="PJN11714"/>
        <property type="gene ID" value="CG723_12685"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PJN11714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="109" mass="12296" checksum="48510DB0F351A959" modified="2018-04-25" version="1">MPHGKTSYVCLPCRVSYKQPYDRDRERICLRCAEPLIHAGSAFAAPRRRDTAAWRTLSVLLHAGVGFHKSCCGGPGFRPRGLREVRERLAYAERSGEPVARALKRYDVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JY01</accession>
    <name>A0A2M9JY01_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GNAT family N-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_12780</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN11728.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN11728">
        <property type="protein sequence ID" value="PJN11728"/>
        <property type="gene ID" value="CG723_12780"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="5"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN11728.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="167" mass="17858" checksum="DA31F9EF7AAF8CC3" modified="2018-04-25" version="1">MTTQPRLEAITPANFETATALKVRPDQEHLVAPVVKSLAEAYVHPGVAWPRLIMDGGRAVGFLMAFFDIDFAGDGTGNDVRSGLWRLNISAGEQGRGYGRFAVESVADEIRSRGGTRLTVTWHPGASGPEGFYLGLGFRLTGEMSDDQVVGELDLAQRPAPGGSRTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JY11</accession>
    <name>A0A2M9JY11_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Epoxide hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CG723_12905</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CB01635</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S33 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN11751.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN11751">
        <property type="protein sequence ID" value="PJN11751"/>
        <property type="gene ID" value="CG723_12905"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033961">
        <property type="term" value="F:cis-stilbene-oxide hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000639">
        <property type="entry name" value="Epox_hydrolase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010497">
        <property type="entry name" value="Epoxide_hydro_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016292">
        <property type="entry name" value="Epoxide_hydrolase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06441">
        <property type="entry name" value="EHN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001112">
        <property type="entry name" value="Epoxide_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00412">
        <property type="entry name" value="EPOXHYDRLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EHN" evidence="4">
        <location>
            <begin position="9"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="3">
        <location>
            <position position="186"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="3">
        <location>
            <position position="312"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="3">
        <location>
            <position position="365"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR001112-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF06441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PJN11751.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="391" mass="43781" checksum="F4DC4AC4ED7F4A3D" modified="2018-04-25" version="1">MPRPSSDVQAFEAQATDADLDDLRARLAAARLPEAETVYRAAPDPRRWEQGVPLADLVEVVNYWRTGYDWRSFEARLNRIGQFRTTIDGLGIHFLHLRSARADATPLILTHGWPGSIAEFIDVVDELADPKDADAPAFHVVVPSLPGFGYSDKPATTGWGIEKIAAAWVELMGRLGYSKFAAHGGDWGGNVTTVLGGRFPAHVLGIHTTFALAPPGLTTDGLTAVERKWTEETRDFWRHHRAYAKQQATRPQTIGYSLVDSPVGLLAWILDKFAEWSDTEDSPFETISRDRILDDVTLYWLTRTGASAARIYYESPNSLDPELRVDVPSAITMYPRDIESRTPRAWAQERYRQIVRWRSPEIGGHFPSLEVPEYFVKDLQEGLAAVLAANR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-09-29" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JYB7</accession>
    <name>A0A2M9JYB7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Cytochrome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CG723_13685</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN11876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN11876">
        <property type="protein sequence ID" value="PJN11876"/>
        <property type="gene ID" value="CG723_13685"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="SSF48264"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PJN11876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="350" mass="38698" checksum="022280EC39DB5314" modified="2018-04-25" version="1">MSLTSAPRTRRTVLAPRLTALLHDHLGHDVFRLESDTVGVAGYDVADRILAARRATETERPTFKPLHGRSISRGEASSVTRAIGDDVREALKRPLPTDADLSGPWPLTGHLFLRDLILGQDPLRLRILMSRNLELTPKLTWSVIAAGAALPGWPRPGAHLTGLAGRAAEAVGYQDRRYAMGVYRRAAAPVCFTVSTLVANALWLGSPFDDSTSNRNIVCEALRLLPPSWNILRNASPEYPAIDGRIRDDDDVLLLPLLSHRDPARWEDAPAFRPERWDELDPDATPGYLPFGHTSERCWGRHMVMPLAELLLDRIRSSGLVVDPGQRTGRVPLLGLLGVEEVRLMKARTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JYF1</accession>
    <name>A0A2M9JYF1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CG723_13825</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN11899.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN11899">
        <property type="protein sequence ID" value="PJN11899"/>
        <property type="gene ID" value="CG723_13825"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PJN11899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="561" mass="63442" checksum="924E475AC21B5E47" modified="2018-04-25" version="1">MALQNEAQTIEEHGEGLVAAAVAGDEEIARRHTDFFVLGRRVDEGIPYWERAVEAGDAFSAYTLARYRKIRGDRREAERLYRLAADRHSGCAYGLAVLLKENGDPEAAEWFREGWEMGRLDCKIELGKLLAAEGKPDEAAEFLMKGVDIGDIAVFRWVQLFEHIRETFDRVADDLEAAEDAEDGEAAGEAVEPLGELDGEFKDYPGLTNEAGNYFCRAGRLSPVALVEHAIFLERHHSDDRWPEVRELLLRSHREGYDGAAFILGLFNEERGELAEAEHWYALAADTGHRAALVRLSDLFRRQRRLDEAEAWLREVDPDDEVVPDRLAKIARLREEDEVPPEQDLRRLQELRQRAEAGDLQASYAYGKMLYEWGGAAARWMLPWHEPAALAGDMAAAADLRWLYDDLGEPVQRDHWKRIAAEAGDHDACGAMAWLSEYHKDYQEAERWYVRAAADNSALNAMLAGKAIAQRGAYEEAEPFLRKAWEEGRDEAFGTETAGYYGLVLNRTGRHEEAVDVLRVAAEHWREDVRSRYDADDLDVLSRMLDPQDELEAAEEALAAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JYJ6</accession>
    <name>A0A2M9JYJ6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Spore-associated protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_14105</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN11945.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN11945">
        <property type="protein sequence ID" value="PJN11945"/>
        <property type="gene ID" value="CG723_14105"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014851276" evidence="1">
        <location>
            <begin position="31"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN11945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="149" mass="15695" checksum="B5612F1C2E68C41B" modified="2018-04-25" version="1">MRFSRPVLTGAALAALALGGTTALAGPASATPNTTPQKVCGSSYKTVNSAPIGSLGTVYLTYNSTNGKNCVATIRKNPGTRLDMSAWIYVSDTDQGDQDYGQYTSYAGPIYVYGKGHCVDWGGNISNVYVQVTGSNCAALREHRVTTTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JYP9</accession>
    <name>A0A2M9JYP9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">3-hydroxyisobutyrate dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CG723_14300</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CB01635</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HIBADH-related family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN11978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN11978">
        <property type="protein sequence ID" value="PJN11978"/>
        <property type="gene ID" value="CG723_14300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016054">
        <property type="term" value="P:organic acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002204">
        <property type="entry name" value="3-OH-isobutyrate_DH-rel_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006115">
        <property type="entry name" value="6PGDH_NADP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015815">
        <property type="entry name" value="HIBADH-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029154">
        <property type="entry name" value="NADP-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14833">
        <property type="entry name" value="NAD_binding_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03446">
        <property type="entry name" value="NAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000103">
        <property type="entry name" value="HIBADH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="SSF48179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00895">
        <property type="entry name" value="3_HYDROXYISOBUT_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD_binding_2" evidence="4">
        <location>
            <begin position="2"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="domain" description="NAD_binding_11" evidence="5">
        <location>
            <begin position="166"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000103-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF03446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF14833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PJN11978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="311" mass="32547" checksum="CC45532DDB0C8218" modified="2018-04-25" version="1">MRIGFIGLGNMGGHMARHLIQAGHQVTVHDTRPEAAAEHVTLGAAWAETAALCASDAEVLVTMLPNPRIVEDVLLRGGVAEALPAGSLWIDMSTSTPAAADRVAAEVLHKRGVRRLDAPVSGMAHGAKAGMLQIFVGGSDADFAAALPVLEVMGDPDRILHVGPLGAGYTVKLMINLLWFTHLTASAEVLAMGVKAGVGLDTLRNALLASPAASNFLENDIMSILTDGDYDDSFAMALACKDLGLAVDLGRDIGVSTELSALVEQIYRRSKAQHGDLAGEMSPVRLYESLAGQEFRLPATQAREAGTPAAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JZT4</accession>
    <name>A0A2M9JZT4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CG723_04945</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000002">
        <property type="protein sequence ID" value="PJN12395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN12395">
        <property type="protein sequence ID" value="PJN12395"/>
        <property type="gene ID" value="CG723_04945"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014883512" evidence="3">
        <location>
            <begin position="30"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="195"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="166"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PJN12395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="221" mass="22457" checksum="F887F4869F455998" modified="2018-04-25" version="1">MTTYRRRSLAVLISGVLCALVAGAGQAQATGYRYWSFWDRDGSAWVYASQGPSTARPSDGDVQGFRFSVSEDSQDSAKPRGAASFDAICADTPAKGGEKRVALVVDFGTAQDAPSGETPPKARAACARVADDATSAEALAAVAKPLRYNNQALLCSIAGFPKTGCGEQVSSAKGTSEGTEPGKSKDAASDGGGPSVGLIAGGAAVVVLGAAAAWQARRRHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JZY4</accession>
    <name>A0A2M9JZY4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CG723_05215</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000002">
        <property type="protein sequence ID" value="PJN12441.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN12441">
        <property type="protein sequence ID" value="PJN12441"/>
        <property type="gene ID" value="CG723_05215"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="SSF54427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PJN12441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="107" mass="11654" checksum="6F4B87F376ED4B2E" modified="2018-04-25" version="1">MAIQTTKLSDPAVRAFVTAVNSHDREAFRAALAPGATMSDDGADRDIDEWTGSEIFESNGHMEIEKESSGGLALTALYRNDAWGEMRTKWQFVVAGGKVTRFETGQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K003</accession>
    <name>A0A2M9K003_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CG723_05320</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000002">
        <property type="protein sequence ID" value="PJN12459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN12459">
        <property type="protein sequence ID" value="PJN12459"/>
        <property type="gene ID" value="CG723_05320"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PJN12459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="200" mass="21007" checksum="E5871281E6374A81" modified="2018-04-25" version="1">MDAVRVALLREVLAGTEWLGAARRFAGALRASVVPHGGGLLLVGTPEYEPWHLAAHLVDEAAWSGMPELSPTLVRHRAGVGGPAHLAVGLGRIEAARRGETLLVVAPGAPGEELLERVHDARRAGATVLAIDSGDRDLHAMAHEALTPGPDLDLDTAQHLVSAAAGENPVGGPARGPRRRFRDRLSRLADHLTSPPPAGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K081</accession>
    <name>A0A2M9K081_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CG723_05695</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CB01635</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000002">
        <property type="protein sequence ID" value="PJN12526.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN12526">
        <property type="protein sequence ID" value="PJN12526"/>
        <property type="gene ID" value="CG723_05695"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002937">
        <property type="entry name" value="Amino_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001613">
        <property type="entry name" value="Flavin_amine_oxidase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01593">
        <property type="entry name" value="Amino_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00757">
        <property type="entry name" value="AMINEOXDASEF"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amino_oxidase" evidence="4">
        <location>
            <begin position="17"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="119"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PJN12526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="449" mass="46871" checksum="46F9DB784433507C" modified="2018-04-25" version="1">MPEPAQHADVVIVGAGVAGLLAAHRLTRAGVPTLVLEAGPCVGGRMSTEKVDGFRLDRIGRLLCTSYPELRRTPGLDALVLRPFSPGVLVHSDGRRHRAGELPASRRARGALTTARALASAPRVPRPRAAARSPRPTAPLGSPLDHARLARSLARLAGTPVPRLLARPELPTADALMGRGLPARTLDGFVRPLLSALLCDPDLTSSSRCADLALLAYARGRLCVPEGGADALPELLAAGLPPGTVRTGVRVRAISANSVTTEEHGELRCRATLLATGARAAAGLLPGLRLPEFHPVTVVHHAVPEPPLTDPALLLDADRLGPVAYSAVISQVDPTRAPAGRALVSSTVLGPPPPERELRAQLAALYGTSTSDWETLAVHHDPEAVPAMPAPHDLRRPVRLLHGLYVCGDHRGTSTVQGALHSGRRAAHAILTDLGVRLAPTAGMVPAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K0F7</accession>
    <name>A0A2M9K0F7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cell division protein FtsL</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_06205</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000002">
        <property type="protein sequence ID" value="PJN12621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN12621">
        <property type="protein sequence ID" value="PJN12621"/>
        <property type="gene ID" value="CG723_06205"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3" id="KW-0132">Cell division</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="33"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="112"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="143"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN12621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="173" mass="17832" checksum="AF467771DC275D67" modified="2018-04-25" version="1">MSPRGELRGRAARLARLLPSGPAGGSQAARTPFVLLVVLLLGGGLITLLMLNSALNEGSFRLNDIKKQTTDLTEDEQALQRDVDAYAAPDSLQRRARELGMVPGGDPAFLNPDGTVRGVPGAAAPSALWRPAPPPPEAVGRTASASPTPSATPKATPNPTSSQVKPAPSTSGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K0L2</accession>
    <name>A0A2M9K0L2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">CoA ester lyase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CG723_06500</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CB01635</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000002">
        <property type="protein sequence ID" value="PJN12671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN12671">
        <property type="protein sequence ID" value="PJN12671"/>
        <property type="gene ID" value="CG723_06500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005000">
        <property type="entry name" value="Aldolase/citrate-lyase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011206">
        <property type="entry name" value="Citrate_lyase_beta/mcl1/mcl2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_Kinase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040442">
        <property type="entry name" value="Pyrv_Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03328">
        <property type="entry name" value="HpcH_HpaI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015582">
        <property type="entry name" value="Cit_lyase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="SSF51621"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HpcH_HpaI" evidence="5">
        <location>
            <begin position="12"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="69"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3 4">
        <location>
            <position position="123"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="149"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR015582-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR015582-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF03328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PJN12671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="278" mass="29428" checksum="E26E9C29237DE6A2" modified="2018-04-25" version="1">MTAQSYETFLTWLYAPGDRPEVVAKALDSGADVVLIDLEDAVAPDRKAYALDATAELLAEKHQVPVHVRVNALNSPRAESEVRRLTPLPGLGALRLPKVHGPADLDRVSDWSVEVPPLYALLESALGVEHAYEIARHPGVRGIALGESDLRAELGLANGEGLAWPRGRAVVAARAAALPPPPQSVYPDIRDTVGLARSCSQGRALGFFGRMAIHPRQLPVIEATFLPTAAEVDAATEVVGAASTEAGALALPDGRFVDAAIVSDARRVLALASRRRGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K0M9</accession>
    <name>A0A2M9K0M9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_06515</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000002">
        <property type="protein sequence ID" value="PJN12674.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN12674">
        <property type="protein sequence ID" value="PJN12674"/>
        <property type="gene ID" value="CG723_06515"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.4080.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005502">
        <property type="entry name" value="Ribosyl_crysJ1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036705">
        <property type="entry name" value="Ribosyl_crysJ1_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03747">
        <property type="entry name" value="ADP_ribosyl_GH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101478">
        <property type="entry name" value="SSF101478"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN12674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="405" mass="43264" checksum="F4DADE90A9AB3DAA" modified="2018-04-25" version="1">MTTPTTAGPTPARTQNSISASTPFSLEDRTTGALVGAAVGDALGGPVEGWTPEAIAERHGGRVRGIVEPFHKDDWRTARPIAPYHKGDGHVTDDTLMTHALIRVYENVRDHLDAYAVADHLVPDLITNTRWIPELEAEALPLQRIFLAEKWIVARIHYGHVDPREAGVGNIVNCGAAMYMAPVGAVNAGNPARAYEEALDVAGAHQSSYGREAAGVFAAAVAAAFRPGATPESVVEDALALAKDGTRSAIEAVCEVARDYTDFEDALGPLREAITPFDTVGPEYRKPSLGARRPSRLHAIEELPIALGMLLVGRGDFRHTVLGSVNYGRDCDSIATMSGAIVGALYGEPAVPREWSGEVARASRLDLHTPAASLARVTREVFAKDMTRRRSHEAAFAELTATAVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K0P3</accession>
    <name>A0A2M9K0P3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Sulfite oxidase-like oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_06075</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000002">
        <property type="protein sequence ID" value="PJN12597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN12597">
        <property type="protein sequence ID" value="PJN12597"/>
        <property type="gene ID" value="CG723_06075"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000572">
        <property type="entry name" value="OxRdtase_Mopterin-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036374">
        <property type="entry name" value="OxRdtase_Mopterin-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00174">
        <property type="entry name" value="Oxidored_molyb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56524">
        <property type="entry name" value="SSF56524"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Oxidored_molyb" evidence="2">
        <location>
            <begin position="33"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN12597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="210" mass="23703" checksum="E38F8DFE54CD7A42" modified="2018-04-25" version="1">MGQPVGRESGGAVQSELPPGQRLQRGWPVTHYGPVPKFRPERWEFRVFGATADGDKHCWTHEEFSALPYGTVVADLHCVTKFSMLGAEWGGVPAATILELAPPAPAVTHVMVWAEYGFSANLRLEDFAADRTIFATHKDGELLTAEHGFPLRLVVPHLYAWKGPKWVRGIEYMTADRRGFWEERGYHNVGDPWREQRYSYQEEPGDGPEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K0S6</accession>
    <name>A0A2M9K0S6_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Peptidoglycan glycosyltransferase</fullName>
            <ecNumber evidence="2">2.4.1.129</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">ftsW</name>
        <name evidence="11" type="ORF">CG723_06235</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CB01635</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>[GlcNAc-(1-&gt;4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)](n)-di-trans,octa-cis-undecaprenyl diphosphate + beta-D-GlcNAc-(1-&gt;4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate = [GlcNAc-(1-&gt;4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)](n+1)-di-trans-octa-cis-undecaprenyl diphosphate + di-trans,octa-cis-undecaprenyl diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23708"/>
            <dbReference type="Rhea" id="RHEA-COMP:9602"/>
            <dbReference type="Rhea" id="RHEA-COMP:9603"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58405"/>
            <dbReference type="ChEBI" id="CHEBI:60033"/>
            <dbReference type="ChEBI" id="CHEBI:78435"/>
            <dbReference type="EC" id="2.4.1.129"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.129" evidence="2"/>
    <dbReference type="EMBL" id="NNBL01000002">
        <property type="protein sequence ID" value="PJN12627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN12627">
        <property type="protein sequence ID" value="PJN12627"/>
        <property type="gene ID" value="CG723_06235"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018365">
        <property type="entry name" value="Cell_cycle_FtsW-rel_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013437">
        <property type="entry name" value="FtsW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001182">
        <property type="entry name" value="FtsW/RodA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30474">
        <property type="entry name" value="PTHR30474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01098">
        <property type="entry name" value="FTSW_RODA_SPOVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02614">
        <property type="entry name" value="ftsW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00428">
        <property type="entry name" value="FTSW_RODA_SPOVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0133">Cell shape</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="47"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="89"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="114"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="150"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="192"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="229"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="306"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="345"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="381"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PJN12627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="437" mass="46696" checksum="005BB86FA7DA93E8" modified="2018-04-25" version="1">MPGSSARAARRSPAARPPKKPARQARVSPVRRLYTQARRAWDRPLTAYYLILGSSLLITVLGLVMVYSASMITALQNGLPSSYYFRKQFLAAVIGGALLFAAMRMPVKLHRALAYPLLTVSVFLMVLVQVPGIGVSIGGNQNWISLGGPFMLQPSEFGKLALVLWGADLMARKHDKRLLTQWKHMLVPLVPVAFLLLGLIMLGGDMGTAILLTAILFGLLWLAGAPTRLFVGVLSVAAAIGVFLIRTSPNRMARLSCLGSTDAGPDDICWQGLHGIYALASGGFFGSGLGASVEKWGQLPEAHTDFIFAITGEELGLAGTLSVLALYAALGYAGIRVAGRTEDPFVRYAAGGVTTWITAQAVVNLGAVLGLLPIAGVPLPLFSYGGSALLPTMFAVGLLIAFARQEPAARAALAMRQPRMRWNTMRRRATARTSGER</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K0U3</accession>
    <name>A0A2M9K0U3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uridine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_07060</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000002">
        <property type="protein sequence ID" value="PJN12763.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN12763">
        <property type="protein sequence ID" value="PJN12763"/>
        <property type="gene ID" value="CG723_07060"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="185"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN12763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="213" mass="23323" checksum="8F34333FAFA1EA65" modified="2018-04-25" version="1">MRLEAITWERLGDALAERLLELKPGDGSPWPRIAVDGPPAARPGDLAALVGEALRVRGRPSLAVDTGGFLRPASLRFEYGREDVEAYYSGWFDTAALWREVFGPLEPGGTGRVLPDLWDPAADRATRSSYVELPPGGVLLLHGPLLMGHWFPFDLTVHLKLSPGALRRRTPEGEQWTLPAFERYDSETDPAGTADVVVRADDPRHPAWGGLPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K142</accession>
    <name>A0A2M9K142_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HATPase_c domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_06970</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000002">
        <property type="protein sequence ID" value="PJN12747.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN12747">
        <property type="protein sequence ID" value="PJN12747"/>
        <property type="gene ID" value="CG723_06970"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13581">
        <property type="entry name" value="HATPase_c_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HATPase_c" evidence="1">
        <location>
            <begin position="27"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN12747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="165" mass="17900" checksum="B29C1B9FECF37B5F" modified="2018-04-25" version="1">MKAVTPPQGHMPQRVAPVHEFAMRFTSTPRGARLARRLISHRLNDWGHPYTSPTNETVTLITAELTANAVRHGHVPGRDFHLRLAEAEGALRVEVTDTRAERLPVTGTPDPDGESGRGLLLVDALADDWGVVPRPSAPGKTVWAELHLRSSERPSVGCGPHPSAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K1A1</accession>
    <name>A0A2M9K1A1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Nucleopolyhedrovirus P10 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_07790</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000002">
        <property type="protein sequence ID" value="PJN12899.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN12899">
        <property type="protein sequence ID" value="PJN12899"/>
        <property type="gene ID" value="CG723_07790"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="133"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN12899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="244" mass="24849" checksum="61B3A6D3221483EF" modified="2018-04-25" version="1">MSADRWTQAVRHQLGLGRLVPLGGPRDGCWLAESAARSALRQAVQSVHGVRLGSLRVELADPDGSYESAVPAPPSALPPGPLRIVAECAAAPDEPLPTAASRLRAALNGAASDGLGLAVAEVDLRVTALLDDGPETEAAPGHSEPDIADGGQAKADSDEERAGQAALSVPGVARLTGSLGGLGRAVHIGERPEGAATLPRRHVRIELAVSGGRRVLDVARDVRTAVTEALADDPSVAVLVTAVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K1B6</accession>
    <name>A0A2M9K1B6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CG723_07560</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000002">
        <property type="protein sequence ID" value="PJN12860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN12860">
        <property type="protein sequence ID" value="PJN12860"/>
        <property type="gene ID" value="CG723_07560"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PJN12860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="205" mass="22251" checksum="D8F7E4198B30A881" modified="2018-04-25" version="1">MAPGHVAYGMRASYGMSHITPDHITAWERGTALPSSTELTALAGALWCAPHQLIGAPRTLREHRLARGLAVEDVARGIGLDVGAYQQMEATGQWGGNHRQSAALASVLALAPRDLISITGREDDLAQLLRDAVGTRWQAHVRAIAKLLSMERRDLDGALREMHQEYQTLMAATLSRAGGSIASGEPGQRYLDDIVDHFWQRVPSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-06-02" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K1Q9</accession>
    <name>A0A2M9K1Q9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">DNA-binding response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CG723_00200</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000001">
        <property type="protein sequence ID" value="PJN13064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN13064">
        <property type="protein sequence ID" value="PJN13064"/>
        <property type="gene ID" value="CG723_00200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00383">
        <property type="entry name" value="trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="2"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="domain" description="OmpR/PhoB-type" evidence="5">
        <location>
            <begin position="130"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="3">
        <location>
            <begin position="130"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PJN13064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="228" mass="24938" checksum="9A9137D6D163EFE3" modified="2018-04-25" version="1">MRLLLVEDDDHVAAALSAVLARHGFEVAHARSGEEALRALVPEADAFGVVLLDLGLPDQDGYEVCGKIRKRTSTPVIMVTARADVRSRIHGLNLGADDYVVKPYDTGELLARIHAVSRRSVPDESSVPAEDGLRLGSVHIELPTRQVSVDGSVVQLTRKEFDLLALLAQRPGVVFRREQIISEVWRTSWEGTGRTLEVHVASLRSKLRMPALIETVRGVGYRLVAPAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K1V7</accession>
    <name>A0A2M9K1V7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Nitrate ABC transporter substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_00455</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000001">
        <property type="protein sequence ID" value="PJN13109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN13109">
        <property type="protein sequence ID" value="PJN13109"/>
        <property type="gene ID" value="CG723_00455"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015168">
        <property type="entry name" value="SsuA/THI5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09084">
        <property type="entry name" value="NMT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014696124" evidence="1">
        <location>
            <begin position="26"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="domain" description="NMT1" evidence="2">
        <location>
            <begin position="60"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN13109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="352" mass="36953" checksum="AA6868C927E3308B" modified="2018-04-25" version="1">MRNTARLCALAATGLLALSSLTACANDAASTSTGSGKKADGKGEHVKIMVGGLDKVIYMPAMLTDRLGYFQDEGLNVQLLSEPAGVQAETALVSGQVQGAVGFYDHTLDLQVKGKAVESVVQFSRAPGEVEIVSNKASGAISSPKDFKGKKLGITGLGSSTDFLTKYLAVKNGVQPSQFSPVAVGAGPTFVSALQKGAIDGGMTTDPTVATILDKKLGKVLVDMRTPEGSQEALGGPYPSSSLYMQTDWVNSHKSTVQKLANAFVKTLKWMSTHSADEIAAKMPADYSQGDKKLYAEAIKATLPMFTTDGVMPKNGPETVESVLKAFNPNIKNAEVDLSKTYTTEFVDKAAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K1W4</accession>
    <name>A0A2M9K1W4_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Histidine kinase</fullName>
            <ecNumber evidence="3">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CG723_00465</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">CB01635</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="3"/>
    <dbReference type="EMBL" id="NNBL01000001">
        <property type="protein sequence ID" value="PJN13111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN13111">
        <property type="protein sequence ID" value="PJN13111"/>
        <property type="gene ID" value="CG723_00465"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013767">
        <property type="entry name" value="PAS_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033463">
        <property type="entry name" value="sCache_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029151">
        <property type="entry name" value="Sensor-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016120">
        <property type="entry name" value="Sig_transdc_His_kin_SpoOB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039506">
        <property type="entry name" value="SPOB_a"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00989">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17203">
        <property type="entry name" value="sCache_3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14689">
        <property type="entry name" value="SPOB_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103190">
        <property type="entry name" value="SSF103190"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55890">
        <property type="entry name" value="SSF55890"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9 15" id="KW-0418">Kinase</keyword>
    <keyword evidence="13" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="20"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="185"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="14">
        <location>
            <begin position="423"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="540"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="543"/>
            <end position="558"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="PJN13111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="569" mass="60705" checksum="82ADBD22F2FC7FC8" modified="2018-04-25" version="1">MSPTPPTRRLRFGLPRRVFAQVLLMQVAIAAGVAVLATGLFLAPLSDQLDDQAMRRALAIAQTTAAQPSIAEDLRHSRPTVDGPVQREAERIRRASGAEYVVIMNREGVRWSHTDPGEVGRIVSTDPSEALAGHEVMEIDSGTLGRSARGKVPLRDAQGDIVGAVSVGIEYDSVRARLIHAIPGLFAYAGGALAVGAVAAYLISRRVQRQTRDLAFSDISGLLSEREAMLHGIREGVVALDRSGRIRLLNDEAHRLLGIGDEVIGQSLDDALGPGRTTDVLAGRATGTDLVTVRGQRVLIANRMPTDDGGAVATLRDRTELEQLGRELDSTRGLIDALRAQDHEHANRMHTLLGLLELEMFDDAVEFVGEVVGDHRATAEQVTEKVHDPLLAALLVGKATVAAERGVALWISDRTLLPDQLIDPRGLVTIVGNLVDNAVDAVAGTPHARVEVDVRATDDHTVELRVRDTGPGIPAARRELIFTEGWSTKKLPSHGKRGIGLPLVRRLAERQGGSVHVGEPDGGGAEFTVVLPEALTDPGLAQEATEAPTTTTAGTAADAMATPTKEDPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-09-29" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K204</accession>
    <name>A0A2M9K204_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 4">Regulatory protein RecX</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">recX</name>
        <name evidence="6" type="ORF">CG723_00150</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CB01635</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Modulates RecA activity.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the RecX family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000001">
        <property type="protein sequence ID" value="PJN13057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN13057">
        <property type="protein sequence ID" value="PJN13057"/>
        <property type="gene ID" value="CG723_00150"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006282">
        <property type="term" value="P:regulation of DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01114">
        <property type="entry name" value="RecX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003783">
        <property type="entry name" value="Regulatory_RecX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33602">
        <property type="entry name" value="PTHR33602"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02631">
        <property type="entry name" value="RecX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="28"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PJN13057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="255" mass="27532" checksum="5CAF596F0B0D832E" modified="2018-04-25" version="1">MTRRTDWADHAYSTSPADLGDGSPGDLDGHGAPRDGDGPRDGDSPRGGGGTRDGGRSRGRRRGSFGEAAGGRQGSGSPTSSRAEKGEPPADPAERARGICLRLLTGQPRTRKQLADALAKRDIPDEVAEEVLSRFEEVGLINDGAFADAWVESRHHGRGLARRALARELRTKGVDSTVIDEAVGQLDSEQEEETARELVARKLRSTRGLDRDKRLRRLAGMLARKGYPEGMALRVVRQALEEEGEETEDLGLGDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K208</accession>
    <name>A0A2M9K208_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CG723_00790</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000001">
        <property type="protein sequence ID" value="PJN13164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN13164">
        <property type="protein sequence ID" value="PJN13164"/>
        <property type="gene ID" value="CG723_00790"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PJN13164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="103" mass="10885" checksum="A561A3DB0B348F23" modified="2018-04-25" version="1">MRCVIARFPFDLFSSDVLDAMKGVKPEPVTGDSVLIGRRRYPVKQVGAVITRQDRRDFTSGEVVRALTALGFTCTEVSAGGSTGPELTPLQAASALMGLPASA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K296</accession>
    <name>A0A2M9K296_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Pvc16_N domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_01285</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000001">
        <property type="protein sequence ID" value="PJN13251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN13251">
        <property type="protein sequence ID" value="PJN13251"/>
        <property type="gene ID" value="CG723_01285"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025351">
        <property type="entry name" value="Pvc16_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14065">
        <property type="entry name" value="Pvc16_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pvc16_N" evidence="2">
        <location>
            <begin position="9"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="200"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN13251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="275" mass="29227" checksum="D33B540B4FA0477C" modified="2018-04-25" version="1">MSNALALAHVTQALALLLESNLGPEIDMAVKVEPRKPPADPPTEPTISVFLYQVTPDTSQRNNDLPTRAADGTLVKRPVAALDLHFLITAYGDETELVGQRLIGSVVRALHEIPVLPKDIIELAGERPYLAGSNLAESAQRVRFTPTVMDVDETSKLWGMLYQTPYTLSVVYQAALVLIDGRETPVAGKPVERPEVRVLPFGAPGAPVPPGAEPTPDVTSNEPAAGDVAKKEAEPPAPSAKKAARTPAKAVAKSPAKAPARTRKTAPRAAKPTQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-05-25" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K2J1</accession>
    <name>A0A2M9K2J1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Sugar isomerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_01765</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000001">
        <property type="protein sequence ID" value="PJN13333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN13333">
        <property type="protein sequence ID" value="PJN13333"/>
        <property type="gene ID" value="CG723_01765"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097367">
        <property type="term" value="F:carbohydrate derivative binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901135">
        <property type="term" value="P:carbohydrate derivative metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05008">
        <property type="entry name" value="SIS_GlmS_GlmD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05009">
        <property type="entry name" value="SIS_GlmS_GlmD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035466">
        <property type="entry name" value="GlmS/AgaS_SIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035490">
        <property type="entry name" value="GlmS/FrlB_SIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001347">
        <property type="entry name" value="SIS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046348">
        <property type="entry name" value="SIS_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01380">
        <property type="entry name" value="SIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53697">
        <property type="entry name" value="SSF53697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51464">
        <property type="entry name" value="SIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="SIS" evidence="2">
        <location>
            <begin position="26"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN13333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="294" mass="31270" checksum="21C5AA8BB273085E" modified="2018-04-25" version="1">MSHIENELHSQPECWDRAAELALDRAALLPEPGERVAIVGCGTSLFMAQAAAALREEAGHGETHAHAASEFPAGRPYDRVVALTRSGATTEVLRLLAGLRGRVRTTVITTDAATPVASAADDVVVLDFADEKSVVQTRFPTSALTLLRTHFGLHSQEVVDDAHDALAEPLPPWLVGCTQFTFLGRGWTVGLAGEAAHKMRESQLPWAGAYPALEYRHGPISVSARGTVTWMLGDAPAGLADEVHATGGMWVAGGLDPLAELVRTQRLAVAVAVAGGRNPDRPRHLTRSVILARV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K2R4</accession>
    <name>A0A2M9K2R4_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Beta_helix domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_01685</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000001">
        <property type="protein sequence ID" value="PJN13317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN13317">
        <property type="protein sequence ID" value="PJN13317"/>
        <property type="gene ID" value="CG723_01685"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039448">
        <property type="entry name" value="Beta_helix"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006626">
        <property type="entry name" value="PbH1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13229">
        <property type="entry name" value="Beta_helix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00710">
        <property type="entry name" value="PbH1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="SSF51126"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014987170" description="Beta_helix domain-containing protein" evidence="1">
        <location>
            <begin position="33"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="domain" description="Beta_helix" evidence="2">
        <location>
            <begin position="201"/>
            <end position="370"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN13317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="519" mass="53932" checksum="74EA5620466103F3" modified="2018-04-25" version="1">MTRTRVSTALVALCAAATAGVTALAAAPAATAASPFKSRAHYVDCRGGTGPQKGTRAAPWRTLAAVNAQHLGPGDQVLLKRGTRCTGTLTPNGAGAPGSPVRIAAYGTGAKPVIDGAGAPDTVLLRNTQWIEVSDLEITNAANPGTKRRGVRVVLSDYGTGRHYRLTGLDIHDIRGDDTKDNDGSAGILFSVTGSAKETRYDDVRVENNTLRTVDREGIFFASSWNQRPAISGYDPNGPHWVPSTGVVVRGNTLNDLGGDGIVMTATKGALVEHNTLHGFQRRSAGYNAGMWPWNADGTVFQYNETSGGETTRDGMAYDVDEGSFGTVFQYNYSHDNAGGFFLVCSADGTLGDAVIRFNISQNDHFRGIETCRGWFSGVRFLHNTIYVGDGVSQTVVNENTTSRHEIAFDNNLVVKQGAGTAAFTLRSGGVTASHNALYGIGAAPANPGGTTADPLLTRPGTATGYVDAGAAYALRPGSPALGAGAPLADAGARDFAGNPVVSGAAPNIGAWNGSSTAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K2U4</accession>
    <name>A0A2M9K2U4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CG723_02405</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000001">
        <property type="protein sequence ID" value="PJN13443.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN13443">
        <property type="protein sequence ID" value="PJN13443"/>
        <property type="gene ID" value="CG723_02405"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="11"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="43"/>
            <end position="50"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PJN13443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="266" mass="28877" checksum="C658AED5309EF1AC" modified="2018-04-25" version="1">MTETAERTALVELDGVSKYYGNIRALEDVSLVVHAGEISCVLGDNGAGKSTLIKIIAGLHRHDSGSFSIEGEETRLANPRESLDRGIATVYQDLAVVPLMPVWRNFFLGSEPTKGSGPFKRLDVDLMRRTTHAELLRMGIDLRDVDQPIGTLSGGERQCVAIARAVYFGAKVLVLDEPTAALGVKQSGVVLKYVAAARDAGLGVVLITHNPHHAYLVGNRFVLLKRGAMFGSYARDEITLDELTRQMAGGSELDDLRHELEGREAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K2W9</accession>
    <name>A0A2M9K2W9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CG723_02585</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000001">
        <property type="protein sequence ID" value="PJN13472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN13472">
        <property type="protein sequence ID" value="PJN13472"/>
        <property type="gene ID" value="CG723_02585"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015833">
        <property type="term" value="P:peptide transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013563">
        <property type="entry name" value="Oligopep_ABC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08352">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01727">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="9"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="43"/>
            <end position="50"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PJN13472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="341" mass="36055" checksum="7B76A0BA9784AE49" modified="2018-04-25" version="1">MSPDPVLSVRDLSVSFRSDTRTVHAVDHVSYELAAGEVLAVVGESGCGKSVTSMAVMGLLPPTAHITGSIRLGTRELAGGDDKAYGKIRGKDIAMIFQEPMTSLNPVLTIGRQIGEVLRRHQGLSKKEARARAVELLDLVGIPAPAQRVDEYPHQLSGGMRQRVMIAIAVACDPAVLIADEPTTALDVTVQAGILEVLQSLRERLGTAIVLITHDLGVVADIADRVLVMYAGRPVEQAPVDELFAAPRHPYTRGLLSAVLRPGASAAADGGGKRRLPEIPGLVPSLDSQPDACTFAPRCARADEQCTTARPGFQSVTDDAGAGAPHRAACWHPNTLQEAAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K359</accession>
    <name>A0A2M9K359_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CG723_02800</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000001">
        <property type="protein sequence ID" value="PJN13510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN13510">
        <property type="protein sequence ID" value="PJN13510"/>
        <property type="gene ID" value="CG723_02800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PJN13510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="145" mass="15532" checksum="55C95127BAFEA407" modified="2018-04-25" version="1">MGPGPPASPSGPVRLTSIPARSAHGAGEVLLHDEGGALVGQVRFRLCAPCRTGRLLGIWILESRRQEGLGRRAVRVALAQGHGYRWNTTLQTRPGRGFFLAVTAHEGVPLGHGRPLCPHLLGPFGNALRRLGLRRLVCPPHDEPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K3F1</accession>
    <name>A0A2M9K3F1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CG723_03665</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000001">
        <property type="protein sequence ID" value="PJN13655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN13655">
        <property type="protein sequence ID" value="PJN13655"/>
        <property type="gene ID" value="CG723_03665"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PJN13655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="289" mass="30896" checksum="430557C07BBF02AF" modified="2018-04-25" version="1">MTTSPDPRAARRCHNMLNPFHSMHYFSPDLGKELGAIGITHRSAAYFAARAAAMGAVGAGTVTATFYNFKHELVAEHVPAVWETASPETVLAARARAVDSTLRRLLGDEIVASPEMAEAAALALRATEACTRHARPLYAAHADLPVPEEPHLAYWHAATLLREHRGDGHVAALLAADLDPVEALVSHVATGKGMAPKWLLATRGWTREEFDAAADRLRERKVLDAQGELTELGAALRHDLEAQTDRLDREPYAHLGEAGVARLTELAGGFMGTALGAGAFPADLIGKAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K3P6</accession>
    <name>A0A2M9K3P6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CG723_01545</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000001">
        <property type="protein sequence ID" value="PJN13751.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN13751">
        <property type="protein sequence ID" value="PJN13751"/>
        <property type="gene ID" value="CG723_01545"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00207">
        <property type="entry name" value="fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036010">
        <property type="entry name" value="2Fe-2S_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001041">
        <property type="entry name" value="2Fe-2S_ferredoxin-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006058">
        <property type="entry name" value="2Fe2S_fd_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000951">
        <property type="entry name" value="Ph_dOase_redase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00111">
        <property type="entry name" value="Fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00409">
        <property type="entry name" value="PHDIOXRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="SSF52343"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54292">
        <property type="entry name" value="SSF54292"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="SSF63380"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00197">
        <property type="entry name" value="2FE2S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51085">
        <property type="entry name" value="2FE2S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding FR-type" evidence="6">
        <location>
            <begin position="1"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="domain" description="2Fe-2S ferredoxin-type" evidence="5">
        <location>
            <begin position="207"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PJN13751.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="292" mass="31063" checksum="2748C6FCC0C183FB" modified="2018-04-25" version="1">MSLTLRHPKADPLPAWEPGAHVDLVLTDDLVRPYSLCGDPADRTAWTVAVLHEPSGRGGSAYVHEKLSPGTVVRVRGPRNHFPLHEAPGYRFVAGGIGITPILPMLAAAEASGAEWSLLYGGRSRDSMAFLGQLSTYGAKVRVAPEDETGLLDLDGYLGPPDTNTLVYCCGPGRLLDAVEARGAAHTERFRPAQDGPDGTGSTDHAFEVELRRSGRTLTVPPGRSILHTAQEAGIEVLYSCAEGTCGTCETDIVEGAADHRDSVLTAEERAAGETLMICVSRCLGPRLVLDM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K3R3</accession>
    <name>A0A2M9K3R3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycosyl transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_03735</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000001">
        <property type="protein sequence ID" value="PJN13667.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN13667">
        <property type="protein sequence ID" value="PJN13667"/>
        <property type="gene ID" value="CG723_03735"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="230"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_trans_2-like" evidence="2">
        <location>
            <begin position="10"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN13667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="294" mass="32405" checksum="CF4ED1D88C10B4D9" modified="2018-04-25" version="1">MSTAMKVGAVIITMGNRPEELRALLDSVAKQDGDRVDVVVVGNGSPVPDVPAGVRTVELPENLGIPGGRNVGIEAFGPSGSDVDVLLFLDDDGLLPKTDTAQLCREAFESDPKLGIVSFRIADPETGVTQRRHVPRLRAADPMRSSRVTTFLGGANAVRTRVIAEVGGLPDEFFYAHEETDLAWRALDAGWMIDYRADMVLHHPTTAPSRHAVYHRMVARNRVWLARRNLPALIVPVYLGVWLLLTLARRPSGPALKAWFGGFKEGWTSPCGPRRPMKWRTVWRLTRLGRPPII</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K3V3</accession>
    <name>A0A2M9K3V3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_03690</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000001">
        <property type="protein sequence ID" value="PJN13803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN13803">
        <property type="protein sequence ID" value="PJN13803"/>
        <property type="gene ID" value="CG723_03690"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13581">
        <property type="entry name" value="HATPase_c_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HATPase_c" evidence="2">
        <location>
            <begin position="43"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN13803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="168" mass="17679" checksum="FA96844BDB8A7CB9" modified="2018-04-25" version="1">MSDQGWGSRPSPQDTGGVPPDQQPGSPLPYEGVWRFTAQAVDASVPQARHAVRDLLVRQGVPASDDLVQGLLLIVSELVTNAVRHAALLSPVLAVEVAVGAEWVRVSVEDEHPYRPTALEATDGQTGGRGLLLVREVTREAGGVCDVEHTASGGKVIWAALPLKPADA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JET8</accession>
    <name>A0A2M9JET8_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Acetoin utilization protein AcuC</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CG723_45055</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CB01635</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Ketone degradation; acetoin degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the histone deacetylase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000050">
        <property type="protein sequence ID" value="PJN05398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN05398">
        <property type="protein sequence ID" value="PJN05398"/>
        <property type="gene ID" value="CG723_45055"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00040"/>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045150">
        <property type="term" value="P:acetoin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd09994">
        <property type="entry name" value="HDAC_AcuC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.800.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003085">
        <property type="entry name" value="AcuC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000286">
        <property type="entry name" value="His_deacetylse"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023801">
        <property type="entry name" value="His_deacetylse_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037138">
        <property type="entry name" value="His_deacetylse_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023696">
        <property type="entry name" value="Ureohydrolase_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00850">
        <property type="entry name" value="Hist_deacetyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01272">
        <property type="entry name" value="ACUCPROTEIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01270">
        <property type="entry name" value="HDASUPER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52768">
        <property type="entry name" value="SSF52768"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0006">Acetoin catabolism</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hist_deacetyl" evidence="6">
        <location>
            <begin position="22"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="197"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022627"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PJN05398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="391" mass="41673" checksum="929C1E97A35D19F8" modified="2018-04-25" version="1">MSGRAQLMWDEAVTGYDFGPDHPMDPVRLALTRSLVGALGLDREVDVVAAKRAGESTLRLVHREDYVEAVKAASADPASADGAYGLGTVDDPAFAGMHDVSALIAGQSVGAAEAVWRGEALHAVNFAGGLHHAMPGGAAGFCIYNDAALAVARLLELGAERVAYVDVDVHHGDGVQAAFWDDPRVLTISLHEHPRTLFPQTGWPEETGADGPAEGSAVNVALPAGTGDAGWLRAFHAVVPELLAEFRPQVLVTQHGADTHFEDPLAHLAVSLDAQRAVQVACHELAHEHADGRWVALGGGGYAVVDVVPRSWSHLVGIAAGHEVAPETVIPESWRQEAFARTRQLAPTRMTDGRWPVSYKEWEAGYDPADRLDQAVLATRRSVFPLRGLLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JF27</accession>
    <name>A0A2M9JF27_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">MR_MLE domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_44460</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000047">
        <property type="protein sequence ID" value="PJN05500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN05500">
        <property type="protein sequence ID" value="PJN05500"/>
        <property type="gene ID" value="CG723_44460"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009063">
        <property type="term" value="P:cellular amino acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036849">
        <property type="entry name" value="Enolase-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029017">
        <property type="entry name" value="Enolase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029065">
        <property type="entry name" value="Enolase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018110">
        <property type="entry name" value="Mandel_Rmase/mucon_lact_enz_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013342">
        <property type="entry name" value="Mandelate_racemase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013341">
        <property type="entry name" value="Mandelate_racemase_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13378">
        <property type="entry name" value="MR_MLE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02746">
        <property type="entry name" value="MR_MLE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00922">
        <property type="entry name" value="MR_MLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51604">
        <property type="entry name" value="SSF51604"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54826">
        <property type="entry name" value="SSF54826"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00909">
        <property type="entry name" value="MR_MLE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MR_MLE" evidence="1">
        <location>
            <begin position="171"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN05500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="398" mass="43049" checksum="5B1B1DCCDC9A4E8E" modified="2018-04-25" version="1">MPDAAPQVLGVLSPTLSDLVHGDEAAEIVSVETYALAVPLTRPIADATAAMDHWTVPVVEIRTRDGLVGTGISGVHTAPELLCSVIDDYYATSLLGASSEDILGTWNRLYWLPTHWIGRAGPVHMALGMVDIALWDLAAQRAGVPLWRLLGGSADPIEAYNTDAGWLNSPVDDLVRGLTGLIDQGWRRVKVKVGKPDWREDAARVRAVRSALGDDATLMCDANQRWDLSTACRIMPVLEETRMDWVEEPLHADDLSGHVTVQRSTGLDIAAGESIYSYQQFNSFISHDAIRVVQPDATRLGGVTEWLQVAGLAAARGLRVAPHAGDMMQLHQHLVGVGLSAAPPLIEFIPWTQDAFVERSVVREGYLQRPQAPGASTAIAPKARHSWQVRGVGALRAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JFY0</accession>
    <name>A0A2M9JFY0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Aldehyde dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CG723_43065</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CB01635</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000042">
        <property type="protein sequence ID" value="PJN05713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN05713">
        <property type="protein sequence ID" value="PJN05713"/>
        <property type="gene ID" value="CG723_43065"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016620">
        <property type="term" value="F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016160">
        <property type="entry name" value="Ald_DH_CS_CYS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="SSF53720"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00070">
        <property type="entry name" value="ALDEHYDE_DEHYDR_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00687">
        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldedh" evidence="5">
        <location>
            <begin position="14"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="254"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PJN05713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="494" mass="52327" checksum="F24DFFE99299CA82" modified="2018-04-25" version="1">MPHHPTDILIAGQWRRGAGEPVETVDPATGEVLATVHSASADEVDEAARAAALAVADPAWRDLLPHQRARLLYRIAELTEEAAGELSALQTADTGKTLTETKALALSAAGTFRYMAAALETAEETLTPSRGPYVTMSVYEPIGVVGAINPWNSPVASDAQKIAPALAGGNAVLLKPAAWTPLVSLALGRLIHQALGELGLPTALLSVLPGSGRVVGDAIVHHPLVTRIGFTGGTETGRSIAAVAASKLIPASLELGGKSPTIVRADADVEQALAGVMFGIFSSSGQSCIAGSRLFVAREIYDSFVGELVERVSKLRVGPGTDPGTQVGPLVHHRHRDSVAAYVDLARSEGARVLCGGRAPEGDTYRDGAYYLPTVLDGLPNTSRTCQEEIFGPVLVALPYDDEDDLVRQANDSVYGLACGIWTRDHRAAWRLARRIEAGTVWINTYKQFSASTPFSGMKDSGLGTEKGRDAIRAYQRQKSLYWGTSDAPLPWAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JG94</accession>
    <name>A0A2M9JG94_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">TetR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CG723_42690</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000040">
        <property type="protein sequence ID" value="PJN05843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN05843">
        <property type="protein sequence ID" value="PJN05843"/>
        <property type="gene ID" value="CG723_42690"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="3">
        <location>
            <begin position="46"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="68"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PJN05843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="264" mass="27751" checksum="D457D64CD9ACF9D7" modified="2018-04-25" version="1">MHIQDSQWTSAASASAVAGGPAATSGGNGRGVGDSSRAAPLRVDAQRNLEHVLRAAREVFGELGYGAPMEDVARRARVGVGTVYRRFPSKDVLVRRIAEEETSRLTDQARAALGQEDEPWSALSRFLRTSVASGAGRLLPPQVLRVGVPDERADAAGGVRDETRVPQQRHAGVAPELRLVEQRTAPVTEAVPADDAGAAELLEVVGQLVDRARAASELRADVTVADVLLVIATAAPSLPDAAQQAAASSRLLDILLEGLRSRPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JGI5</accession>
    <name>A0A2M9JGI5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Nitric oxide synthase oxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CG723_41855</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CB01635</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000037">
        <property type="protein sequence ID" value="PJN05995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN05995">
        <property type="protein sequence ID" value="PJN05995"/>
        <property type="gene ID" value="CG723_41855"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004517">
        <property type="term" value="F:nitric-oxide synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006809">
        <property type="term" value="P:nitric oxide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.340.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.440.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044943">
        <property type="entry name" value="NOS_dom_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044940">
        <property type="entry name" value="NOS_dom_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044944">
        <property type="entry name" value="NOS_dom_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004030">
        <property type="entry name" value="NOS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036119">
        <property type="entry name" value="NOS_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02898">
        <property type="entry name" value="NO_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56512">
        <property type="entry name" value="SSF56512"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS60001">
        <property type="entry name" value="NOS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0349">Heme</keyword>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NOS" evidence="7">
        <location>
            <begin position="125"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="33"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS60001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PJN05995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="432" mass="47940" checksum="E0E6742FAA2EDB1B" modified="2018-04-25" version="1">MSARRGTESRVETEPSPGAEASRSGTIAARRAPPPADTPPPPPASATPAASTPAAPIPVTRPPRTPELWPAASGFIRAHHDEERLGDPAARLAEAYAEIADTGTYRHTERELTFGARVAWRNANRCIGRLYWNSLHVRDRRHLTAAEDIAAACTDHLREASQGGRIRPLITVFAPDAPDRPGPRIWNEQLIRYAGYVQRDGRVVGDPRNEGLTALARRLGWRGGDGTPFDVLPLIVQGTDDKPRCFDLPPDAVLEVPIEHEDHDWWAGLRLRWHAVPALSTMCLEIGGICYQAAPFNGWYMGTEIGARNLADTDRYDLLPRIAERLGLDTTSDRSLWKDRALVELNRAVLFSFDRAGVTVTDHHTESRRFLTHLDREERKGRTVGADWSWIVPPISGSATPVFHRTYDTTERTPAYVQHPEALARASGEFLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JGP4</accession>
    <name>A0A2M9JGP4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Fic family toxin-antitoxin system, toxin component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CG723_41355</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000036">
        <property type="protein sequence ID" value="PJN06051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN06051">
        <property type="protein sequence ID" value="PJN06051"/>
        <property type="gene ID" value="CG723_41355"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PJN06051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="128" mass="13886" checksum="5458576C79F56A7C" modified="2018-04-25" version="1">MTQPVPEHPLDVTFLLHAAELLDGDPQVDDYGPLYAAVARVNARALEHDIYGTLNLKAGALLQTLARLPCLEHSNAAFAWHATEAYLILNGSRLDYPVKAAVELVRDAASTQVGVAGIARQLRDWTVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JGP7</accession>
    <name>A0A2M9JGP7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Serine dehydratase</fullName>
            <ecNumber evidence="4">4.3.1.19</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CG723_41915</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CB01635</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.3.1.19" evidence="4"/>
    <dbReference type="EMBL" id="NNBL01000037">
        <property type="protein sequence ID" value="PJN06012.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN06012">
        <property type="protein sequence ID" value="PJN06012"/>
        <property type="gene ID" value="CG723_41915"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004794">
        <property type="term" value="F:L-threonine ammonia-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901607">
        <property type="term" value="P:alpha-amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="PLP-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="Trypto_synt_PLP_dependent"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="SSF53686"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PALP" evidence="3">
        <location>
            <begin position="20"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PJN06012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="322" mass="34438" checksum="065C98EA2B8B20A6" modified="2018-04-25" version="1">MTPSDLPTYEDVVRAHERVAPHAHRTPVLTSRLTDAELGASLHFKCENFQRMGAFKFRGAFNALSKFSPEQRRAGVVAYSSGNHAQAVALSAAILEMPATIVMPHDAPAAKLAATKGYGAEVVMYDRYTENVEEIGHRVAAERGLTLIPPYDHPDVMAGQGTAAKELFEEVGELDALFVPLGGGGLLSGSILAARALSPGCAVYGVEPEAGDDGRQSLREGRIIDIDTPQTIADGAQTRHLGKHTFAVIKDGVDDILTATDDQLVECMRIFHTRMKTVVEPTGCLGFAAARALAGQLRGRRVGVIVSGGNVDIARFTELLRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JGR6</accession>
    <name>A0A2M9JGR6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_41230</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000036">
        <property type="protein sequence ID" value="PJN06032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN06032">
        <property type="protein sequence ID" value="PJN06032"/>
        <property type="gene ID" value="CG723_41230"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="226"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN06032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="270" mass="29404" checksum="3EE82E7738E14259" modified="2018-04-25" version="1">MTHDEYTDHCEELFAVGGFSQVRKLAESGLEALGPDPVLYRWLGLAHAAEDEDDHDADAEKAYETGLAQWPDDLGLLVSYLELCLRADEWTYPGRSGRAGLLKERIAVLAPAGSPEAARVEAALGWAGRGYWQDVRERTATARAERATLMSHSADVAEALEQGGQAPAHPEDLRAAEVAAALELLAGPWRAPLRLMVRHRVAAYVATFVLVLATNKALVLSGTVSYSVWGWIWFAPLLLADSKLKQARRLARQRVIAAMEARHADTATAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JGX2</accession>
    <name>A0A2M9JGX2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_40995</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000035">
        <property type="protein sequence ID" value="PJN06121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN06121">
        <property type="protein sequence ID" value="PJN06121"/>
        <property type="gene ID" value="CG723_40995"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002514">
        <property type="entry name" value="Transposase_8"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01527">
        <property type="entry name" value="HTH_Tnp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="69"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN06121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="105" mass="12145" checksum="46FC95A83B7A8515" modified="2018-04-25" version="1">MSIMESMGKKKPRHRRSFTAEFKAEIVELCRRGDRSVGQIAKDFDLTETAVRQWVSQAEVDAGEKDGLTSSEREELAALRRENRRLREDVDILKRATAFFAKETR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-09-29" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JH07</accession>
    <name>A0A2M9JH07_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">D-glutamate deacylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_40525</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000034">
        <property type="protein sequence ID" value="PJN06164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN06164">
        <property type="protein sequence ID" value="PJN06164"/>
        <property type="gene ID" value="CG723_40525"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016811">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013108">
        <property type="entry name" value="Amidohydro_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023100">
        <property type="entry name" value="D-aminoacylase_insert_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07969">
        <property type="entry name" value="Amidohydro_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="SSF51338"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydro_3" evidence="1">
        <location>
            <begin position="44"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="domain" description="Amidohydro_3" evidence="1">
        <location>
            <begin position="376"/>
            <end position="471"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN06164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="491" mass="51195" checksum="9F1A4A498CDC6A4A" modified="2018-04-25" version="1">MQTLLRGGRVIDPGTGFDGIADVLVSDGVVRAVAAGLDVPPGCEVVDVSGLVVGPGFVDLHSHVHSIAGQRLQAMDGVTTALDLESGLMPIGRAYAEAAADGRPLHYGFSASWGGARAQVLAGIQPDAQIGSGLAVLGNPAWQRSSTDRELAEWLALIEGELAAGALGIGVLLGYAPHSEPAEFLAVARLAAKAGVPTYTHVRELVEVDPSTPADGSEEIVIAAAETGAAMHHCHVNSTSGHHIDRVLGVLDGSRRSGSRVTVEAYPYGAGSTAIGAVFLDVERLRMKGLSPSSVVMLESGERIADAGRLRQLRNSDPGAPCLLEFLDEGNPRELAMLHQALAFPDAIVASDAMPVYWPDGSNDSTEWPLPPGGTTHPRTAGTFTKTLRVMVRESGAWDWPEAFRRCAHLPARVLDDVAPGARAKGHLGVGADADIVVLDPVAITDCATYFDSTRPSVGVRHLFVGGVPVVSAGELQVDALAGQPLRGEPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-09-29" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JH53</accession>
    <name>A0A2M9JH53_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="10">DEAD/DEAH box helicase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CG723_40630</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000034">
        <property type="protein sequence ID" value="PJN06182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN06182">
        <property type="protein sequence ID" value="PJN06182"/>
        <property type="gene ID" value="CG723_40630"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 10" id="KW-0347">Helicase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Q_MOTIF" evidence="9">
        <location>
            <begin position="76"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="7">
        <location>
            <begin position="107"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="8">
        <location>
            <begin position="303"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="466"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="5">
        <location>
            <begin position="76"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="29"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PJN06182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="504" mass="53550" checksum="22D894D70D18776E" modified="2018-04-25" version="1">MNPTRTNNRSARTRSRTDGPAFGSGAGSQRGSRFGSPAPSRSGGPSRTGGHGRRPAAASGEFALPKTITPALPAVEAFADLDMPERLLASLTAQGMRVPFPIQGATLPNTLAGRDVLGRGRTGSGKTLAFGLALLARTTGQRAEPGQPLALILVPTRELAQQVTDALTPYARSVRLRLATVVGGMPIGRQVSALRGGAEVVVATPGRLKDLIDRGDCRLNQVAITVLDEADQMADMGFMPQVTALLDQVRPEGQRMLFSATLDRNVDLLVRRYLTDPVVHSVDPSAGAVTTMEHHVLHVHGADKHRTTTEIAAREGRVIMFLDTKHAVDRLTQDLLNSGVRAAALHGGKSQPQRTRTLAQFKTGHVTVLVATNVAARGIHVDNLDLVVNVDPPTDHKDYLHRGGRTARAGESGSVVTLVTPHQRRGMVRLMSDAGIRAQTTQIRSGDEALSRITGAQAPSGIPVTVTAPVAERPKRSASSRGRRRPSSATRRAPVRQSVFDAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-05-25" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JHW2</accession>
    <name>A0A2M9JHW2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Thioredoxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">trxA</name>
        <name evidence="4" type="ORF">CG723_39350</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000030">
        <property type="protein sequence ID" value="PJN06464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN06464">
        <property type="protein sequence ID" value="PJN06464"/>
        <property type="gene ID" value="CG723_39350"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015035">
        <property type="term" value="F:protein-disulfide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005746">
        <property type="entry name" value="Thioredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017937">
        <property type="entry name" value="Thioredoxin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01068">
        <property type="entry name" value="thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00194">
        <property type="entry name" value="THIOREDOXIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="3">
        <location>
            <begin position="21"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PJN06464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="147" mass="15742" checksum="C94BD2F37FCAF4FB" modified="2018-04-25" version="1">MATSRTKTVVCESCGRKNRVPAAGAGRPKCGNCGAPLPWIVDAGDDDFAEIAEKAAPIVLVDLWATWCGPCRMVSPALEQVARELAGKIKLVKVDVDQAPRLSQRFQVQAVPTLLLLDQGKAIARQAGAAPANVLRQWVEETIAGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JHX8</accession>
    <name>A0A2M9JHX8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ABC transporter substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_38805</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000029">
        <property type="protein sequence ID" value="PJN06496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN06496">
        <property type="protein sequence ID" value="PJN06496"/>
        <property type="gene ID" value="CG723_38805"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042597">
        <property type="term" value="C:periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030678">
        <property type="entry name" value="Peptide/Ni-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039424">
        <property type="entry name" value="SBP_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000914">
        <property type="entry name" value="SBP_5_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30290">
        <property type="entry name" value="PTHR30290"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00496">
        <property type="entry name" value="SBP_bac_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002741">
        <property type="entry name" value="MppA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014812517" evidence="1">
        <location>
            <begin position="33"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="domain" description="SBP_bac_5" evidence="2">
        <location>
            <begin position="108"/>
            <end position="501"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN06496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="590" mass="63969" checksum="AC17362528053266" modified="2018-04-25" version="1">MEGIPTIMRRSSIAAVAAIGSVSLLLAGCSKADDGSGDNNKSAGANAATKDFVNASTTKGGTVTYAMSDVPDSFDPGNTYYAYMYNFSRLYARPLMTFKPDAGEKGNTLVPDLASAPGKQSDGGKTWTYTIRKGLKYQDGSPITSKDVKYAVERSNFARDVLSLGPNYFQQFLAGGDKYKGPYKDKSDKGLKSIETPDDTTIVFHLNQAFQEFDYLVATPQTAPVPKAKDDGIDYVKHIVSSGSYQFQSYQEGKQAVLVRNKNFDPKSDPLRKQYPDKIVVNLKVNQQTIDKDLQSGDTLIDLQGKGVDTQTQAQLVNDKSKMANTDNAFGGRLVYAAINTKLKPFTNVECRKAVEYAIDKVSVQTAQGGPIRGDVATTVLPPDITGYAKEDVYATSGNKGDVAKAKDALKACGEKKINTTITARSDRDEEVSGAQALIESLKKVGINASLKQYPSGKYFTDYAGVPKFNQKNNVGIMMMQWGADWPSGYGFLQQILNSKAVGASGNTALSELDDKKVDSMLAEAIGAPDEATRNKLYAQIDKQAMEDAALVPLTYFKVLLYRSPYATNLVSTAAFSGQYDYLNIGTTKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JI56</accession>
    <name>A0A2M9JI56_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NADP oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_38860</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000029">
        <property type="protein sequence ID" value="PJN06533.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN06533">
        <property type="protein sequence ID" value="PJN06533"/>
        <property type="gene ID" value="CG723_38860"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028939">
        <property type="entry name" value="P5C_Rdtase_cat_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03807">
        <property type="entry name" value="F420_oxidored"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F420_oxidored" evidence="1">
        <location>
            <begin position="2"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN06533.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="219" mass="23190" checksum="514781571D1182BF" modified="2018-04-25" version="1">MKIGIIGAGNIGGNLTRRFTAAGHDVSVANSRGPETLRDLAEETGATPVTVAEAARGADVVVVTVPMKAVPGLPDDLLDDAPEGVTVIDTGNYYPQQRDGRIAAIEEGMPESRWTELQIGHPVVKVFNGTYAHELLDKPRPKGDPERIALPVAGDDEAAKTVVRGLLDGIGFDSVDTGSLDESWRQQPGTPVYGLAADTDTVRKALAEASPERTAEWRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-09-29" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JIG0</accession>
    <name>A0A2M9JIG0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Penicillin acylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CG723_37995</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CB01635</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S45 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000027">
        <property type="protein sequence ID" value="PJN06671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN06671">
        <property type="protein sequence ID" value="PJN06671"/>
        <property type="gene ID" value="CG723_37995"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016811">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017000">
        <property type="term" value="P:antibiotic biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1400.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.439.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043147">
        <property type="entry name" value="Penicillin_amidase_A-knob"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023343">
        <property type="entry name" value="Penicillin_amidase_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002692">
        <property type="entry name" value="S45"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34218">
        <property type="entry name" value="PTHR34218"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01804">
        <property type="entry name" value="Penicil_amidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="SSF56235"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014708927" evidence="3">
        <location>
            <begin position="43"/>
            <end position="951"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="336"/>
            <end position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PJN06671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="951" mass="102517" checksum="4F952312170DE9B9" modified="2018-04-25" version="1">MRRRTPRTSQHRSLRRTLKRTAATAVFVLTAGLLSPAGGASAAEPPPAPDYCAGRCADILPPGANGSATLAEILGHRVLGTQPAHADDQLGPYDALSAGYPSLTDDTLTQFFNDSSFGVPDGQVGSVTRPRDDVTITRDKKNGVPHVKGSTRYGTEFGAGYAAGQDRLWLIDLFRHIGRGELTSFAGGALANQGLEQEFWPQAPYTEQDLERQVEYIRTTQGERGKQAMDDAQAYIDGLNAYREKSKNGRYFPGEYVLTGKIDAITNVGEIQPFKVTDMIALASVVGGLFGGGGGGEVGQALSLLSAQQKYGVERGTEVWESFRGRDDPEAVATIHDGTSFPYGAKPKNPRGEALPDKGTVESEPLVYDREGSAKPAEAGRRTPVKAPAKLKPLQGMYDRGVLPADTFRNSDSKKGMSNALLVSGKHTASGHPVAVFGPQTGYFAPQLLMMQELQGPGISARGVSFAGVGMYIQLGRGQDYAWSATSAGQDITDTYAVELCEPGGGTPTRQSTSYLYRGTCTPMEKLEKKNAWKPTLADSTAAGSYRMQVFRTKYGIVTHRATVDGKPVAYTSLRSTYRHEADSIIGFQMLNDPSYVKDAATFEKAAQHISYAFNWFYADSRDIAYYNSGANPVRADDVDASFPVKAEQAYEWRDFDPADNTAAYSPPSEHPNSVDQDYYISWNNKQAKGFGAANFSLGAVHRADLLDGRVKKLTAEGGVTRASLTQAMEEAALTDLRGEQVLPEILKVVRSKPVDDPALNKAVQQLEAWRKAGAQRNQTAAGSHTYAHPDAVRIMDAWWPLLVKAEFEPGLGGDLYGALTGQLTVDESPSAGHGPTGAHAGSAFQYGWWGYVDKDLRTVLGQPVKGKLGAAYCGGGKLDACRDALLATLTQAAAEPAAEVYPGDDACKAGDQWCSDTIIHRALGGITHRGIQWQNRPTYQQVVEFPSHRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JII3</accession>
    <name>A0A2M9JII3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">IclR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CG723_38420</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000028">
        <property type="protein sequence ID" value="PJN06577.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN06577">
        <property type="protein sequence ID" value="PJN06577"/>
        <property type="gene ID" value="CG723_38420"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014757">
        <property type="entry name" value="Tscrpt_reg_IclR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005471">
        <property type="entry name" value="Tscrpt_reg_IclR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09339">
        <property type="entry name" value="HTH_IclR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01614">
        <property type="entry name" value="IclR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00346">
        <property type="entry name" value="HTH_ICLR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51077">
        <property type="entry name" value="HTH_ICLR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51078">
        <property type="entry name" value="ICLR_ED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH iclR-type" evidence="4">
        <location>
            <begin position="2"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="domain" description="IclR-ED" evidence="5">
        <location>
            <begin position="62"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="244"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PJN06577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="270" mass="29356" checksum="A79DCE9900B5B8C7" modified="2018-04-25" version="1">MSQTVDRALSILPLLAEGPADLGQVADRLGVHKSTALRLLRTLHEHGLVYRQSDQRYRLGARLFALAQEAVENLDVREIAHPHLTALNEKCGHTVHLAVYEENEVLYIDKVESRYPVRMYSRIGKPVAITVAAVAKLLLADLPETERRAIAEKLDYPTYTARSTPNAGAFLKELAVVREQGWATDLGGHEESINCVGAPIRGADGRVVAAMSVSAPNVVVTAEELLTLLPLVRRTADAISREYSGAVPVSKEAPTKAAGKEAPTKEVTSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-05-25" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JIP6</accession>
    <name>A0A2M9JIP6_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Glutamate-1-semialdehyde 2,1-aminomutase</fullName>
            <shortName evidence="7">GSA</shortName>
            <ecNumber evidence="7">5.4.3.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Glutamate-1-semialdehyde aminotransferase</fullName>
            <shortName evidence="7">GSA-AT</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7 9" type="primary">hemL</name>
        <name evidence="9" type="ORF">CG723_37195</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CB01635</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>(S)-4-amino-5-oxopentanoate = 5-aminolevulinate</text>
            <dbReference type="Rhea" id="RHEA:14265"/>
            <dbReference type="ChEBI" id="CHEBI:57501"/>
            <dbReference type="ChEBI" id="CHEBI:356416"/>
            <dbReference type="EC" id="5.4.3.8"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Porphyrin-containing compound metabolism; protoporphyrin-IX biosynthesis; 5-aminolevulinate from L-glutamyl-tRNA(Glu): step 2/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.4.3.8" evidence="7"/>
    <dbReference type="EMBL" id="NNBL01000026">
        <property type="protein sequence ID" value="PJN06722.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN06722">
        <property type="protein sequence ID" value="PJN06722"/>
        <property type="gene ID" value="CG723_37195"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00251">
        <property type="reaction ID" value="UER00317"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042286">
        <property type="term" value="F:glutamate-1-semialdehyde 2,1-aminomutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006782">
        <property type="term" value="P:protoporphyrinogen IX biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00610">
        <property type="entry name" value="OAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00375">
        <property type="entry name" value="HemL_aminotrans_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004639">
        <property type="entry name" value="4pyrrol_synth_GluAld_NH2Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005814">
        <property type="entry name" value="Aminotrans_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00202">
        <property type="entry name" value="Aminotran_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00713">
        <property type="entry name" value="hemL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00600">
        <property type="entry name" value="AA_TRANSFER_CLASS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 7" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6 7" id="KW-0627">Porphyrin biosynthesis</keyword>
    <keyword evidence="4 7 8" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="7">
        <location>
            <position position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008981"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PJN06722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="454" mass="46945" checksum="E63B0017D2A9BA24" modified="2018-04-25" version="1">MAEANNIPGSAAPPSGATAPYPYEAPVSQGLFDRAALVTPGGVNSPVRAFRAVGGTPRFMVSGTGPYLTDADGREYVDLVCSWGPMILGHSRPEVIAAVQEAVARGTSFGTPGEGEVALAEEIVARIAPVEQVRLVSSGTEATMSAIRLARGFTGRAKVIKFAGCYHGHVDALLAAAGSGVATLGLPDTPGVTGAQAGDTIVVPYNDLDAVRVAFAANEGQVACVITEASPGNMGVVPPLEGFNQGLADLCRENGALYISDEVMTGFRTSKAGWYGVDGVAPDLMTFGKVMGGGFPAAAFGGRADVMGHLAPAGPVYQAGTLSGNPVATAAGVAQLRLLDDAAYAKIDAVSEQLRTLVGAALTKEGVAHRVQSASNMFSVFFTENEVRNYEDAKRQESFRFTAFFHSMLEQGVYLPPSAFESWFVSTAHDERAVERIAAALPGAARAAAEATQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JIY2</accession>
    <name>A0A2M9JIY2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_36670</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000025">
        <property type="protein sequence ID" value="PJN06821.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN06821">
        <property type="protein sequence ID" value="PJN06821"/>
        <property type="gene ID" value="CG723_36670"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032722">
        <property type="entry name" value="Deaminase_XOO_2897"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025851">
        <property type="entry name" value="SUKH-4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14435">
        <property type="entry name" value="SUKH-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14440">
        <property type="entry name" value="XOO_2897-deam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN06821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="403" mass="42225" checksum="C2B0E2F2C2779DA5" modified="2018-04-25" version="1" fragment="single">PAGPGAPPPPAAPGVPGAPGGGVHHAATMLAGPGQVGPGMPPPAPPQAPGGMPMPPPMPGQQVPGGPPPASYGYPQPTGQPTVGPGYQAVLRYRAPDGSEQQLIRRSAPGTPHPEWQIFHELRGMNVPPDQVLELHTELESCELPGAYCARMIREQWPQARITSIAPYGRDHASRQQGMQQLIAHQGELHQVADGPARLAPVRAPLPPAQPMPPVPPEAVGQELAAAFGPGVFRFDQRAVSRQGVPDLVAHTLVVAGLPADFGPFFWAQAQPGRPVPTLAELAQERGVQPAADAGSYLVMGSDFGRAICVQYGTANIVAVPVEAGPGGAPVPPQFVNTGLPEFARSLAVLGRMWPLRFGLNQEQAGRWTVDFQAQLAAVDPAALASPEGWWSVLLEQMWDGLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JJI1</accession>
    <name>A0A2M9JJI1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_36650</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000024">
        <property type="protein sequence ID" value="PJN07023.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN07023">
        <property type="protein sequence ID" value="PJN07023"/>
        <property type="gene ID" value="CG723_36650"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="223"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="264"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="314"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN07023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="366" mass="39203" checksum="3D381ECB28A8BA00" modified="2018-04-25" version="1">MALLADPDAPTEIAQRMAQTLTARLADKSGQGRRFDVEVVSEPFTAGTEDLPTLMRRIMDRGSSEDWDIVVALTDLPLHTHGRKLVVNLSHEHGLALLSLPSLGGFRLYTRARRAVEEAVLGLAGPKATGAEGPSQSQPSLGPFAGRLAPIHPVPVGGEETSDLRYVVSGPRGYLRVLVGMVRANRPWRLVPGLSKALAAALATGAVATVNSTVWSLAEALGAPRLVIAMVGSVGVMIGWLIVDAQLWHRSAEGSLEARQRARLYNASTVVTVGIGVLVCYVGLMVINLVWALFILNDQVFASMTRTPLHATGYWTLSWFVASVATVGGALGSGLESDEAIRAAAYSKREQERRLMLQDDHGDYLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JJS3</accession>
    <name>A0A2M9JJS3_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">AP_endonuc_2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_35950</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000023">
        <property type="protein sequence ID" value="PJN07120.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN07120">
        <property type="protein sequence ID" value="PJN07120"/>
        <property type="gene ID" value="CG723_35950"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036237">
        <property type="entry name" value="Xyl_isomerase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013022">
        <property type="entry name" value="Xyl_isomerase-like_TIM-brl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01261">
        <property type="entry name" value="AP_endonuc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51658">
        <property type="entry name" value="SSF51658"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AP_endonuc_2" evidence="1">
        <location>
            <begin position="25"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN07120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="270" mass="30418" checksum="1F6E46BBC9342795" modified="2018-04-25" version="1">MVRIPDAKVALSTASVYPESTATAFEIAARLGYDGVEVMVWTDPVSQDIEALRRLSDYHQVPILAVHAPCLLITQRVWSTDPWTKLQRAKSAAEKLGASTVVVHPPFRWQRQYARDFVDGIWRMADETEVRFAVENMYPWRYRDREMLAYAPDWDVTKDDYRHFTIDLSHTATARTDAMSMIDRMGDRLGHVHLADGGGSSKDEHLVPGRGTQPCAELLERLALTGFDGHVVIEVNTRRAMSSAEREADLAEALAFTRLHLASAVRVPRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JJT9</accession>
    <name>A0A2M9JJT9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">D-alanyl-D-alanine carboxypeptidase/D-alanyl-D-alanine-endopeptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">dacB</name>
        <name evidence="3" type="ORF">CG723_35645</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S13 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000023">
        <property type="protein sequence ID" value="PJN07141.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN07141">
        <property type="protein sequence ID" value="PJN07141"/>
        <property type="gene ID" value="CG723_35645"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004185">
        <property type="term" value="F:serine-type carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000667">
        <property type="entry name" value="Peptidase_S13"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30023">
        <property type="entry name" value="PTHR30023"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02113">
        <property type="entry name" value="Peptidase_S13"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00922">
        <property type="entry name" value="DADACBPTASE3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00666">
        <property type="entry name" value="PBP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="45"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="260"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="293"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="69"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="293"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN07141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="497" mass="50579" checksum="BFE16EA5568B6FE3" modified="2018-04-25" version="1">MPELKASQAVSQAVKVLTKVKTWQLTAGAATLGLALSAVAVASAGPWDSSGQRTAEARRAASQEAGGGADHGRDGRDGRSGEPDAAPSARAVLAAPGGSVPGPTKGALADVLDPLLNDPALGKRRTAAVVDAATGQRLYGKSSGDALTPASTTKLATAVAALSMPGSDHRIDTKTVIEPGSKAHEVVLVGGGDPTLTARKDAGPNASLRALADATAKELKGRDTDEITLSYDTSLYSGPLLHPIGPNENIAPVSALMADEARTDDSSSGPAPRESDPAAAAARKFADLLHDRGIRTKGEPGPRHASGDAEKLAKVSSPPVSALVERMLTHSDNDIAEALARQVALATDEAASFEGGGEGIRKELEKLRIPLSGSHFADGSGLDRADKVSADLLTQVLAHAVERERPGLRPVLTGLPVAGFTGTLSKRYTDEADAAGIGLVRAKTGTLTGVNTLAGTVVDADGRLLVFAFMTDGTVNPGQAQAALDRLASTVANCGCR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JJX8</accession>
    <name>A0A2M9JJX8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CG723_34875</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CB01635</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000022">
        <property type="protein sequence ID" value="PJN07180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN07180">
        <property type="protein sequence ID" value="PJN07180"/>
        <property type="gene ID" value="CG723_34875"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003838">
        <property type="entry name" value="ABC3_permease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025857">
        <property type="entry name" value="MacB_PCD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02687">
        <property type="entry name" value="FtsX"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12704">
        <property type="entry name" value="MacB_PCD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="265"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="318"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="360"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="410"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="437"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="493"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="724"/>
            <end position="753"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="778"/>
            <end position="803"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="815"/>
            <end position="838"/>
        </location>
    </feature>
    <feature type="domain" description="MacB_PCD" evidence="8">
        <location>
            <begin position="18"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="domain" description="FtsX" evidence="7">
        <location>
            <begin position="295"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="domain" description="MacB_PCD" evidence="8">
        <location>
            <begin position="493"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="domain" description="FtsX" evidence="7">
        <location>
            <begin position="757"/>
            <end position="847"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF12704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PJN07180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="855" mass="88533" checksum="D935E7ACAEE61E06" modified="2018-04-25" version="1">MLKATLRSFLAHKGRLVLSGLAIVLSVAFVAGSLVFSDTVTRTFDRLFASTSADVQVNPKQDSLGESVPTGAVETVPARLARQIRSIDGVAAARIDAAAENITVVDDKNKSVGPTSGAPTIATNWYVTDRSPVRLTSGHAPRGSGEALLDADTADKKRIRIGDSLTVLAQPGSFTVRIVGIATFRTTNPGAALVFLDTAAAQVKLLGSTDRATSISVDAAPGVSDAALKQRIAQQLGSGYDLKTAGEQATSDAADLGSFLDVIKYVMLGFAGIAVLVGIFLIVNTFSMLIAQRTRELGLLRALGADRRQVRRSVLTEAVLLGLVGSVLGLAAGIGLALGLIKLMSAFGMNLKSTEMVIGWGTPVAAFAVGVGVTFVAAYLPSQRASRVSPMAALADAEIAGAGRPLRVRAVAGTVVGVAGAAALVGCAAATKTASASLLLVVGIVLTLLATVIAGPLLVRPVIRVLGGAFPAVFGSVGRLSQRNALRNPRRTGATAAALMVGLALVASMSVASASMSKSFDEQIDKTLGADFTVQNSNFMPFPNEVTDRIRATEGAGLVVRQRFVPLAVRLPDGTRVKTTAAGYEAQLDDVAHVTYSQGDSAAALAPGKVAMDAEFAKEHHARVGTVVPVDLPGGRTDRLTVAALTDQGSGDGFGMSGGLFMGMGTLEKFLPDGQDSAVYVNASPGTGADVLRARLEKVLDPYPQVQVRDLADYKKLVHDQIAVLLYLVYALVGLAIVIAVLGVVNTLALSVVERTREIGLLRAIGLSRRQLRRMIRLESVVIAVFGAVLGLTLGVVWGLAIHEVLALQGMEALAIPWGTIVAVVVGSVVVGLAAALLPALRASRMNVLAAIAHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JKU9</accession>
    <name>A0A2M9JKU9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Penicillin amidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CG723_34005</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CB01635</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S45 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000020">
        <property type="protein sequence ID" value="PJN07501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN07501">
        <property type="protein sequence ID" value="PJN07501"/>
        <property type="gene ID" value="CG723_34005"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016811">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017000">
        <property type="term" value="P:antibiotic biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1400.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.439.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043147">
        <property type="entry name" value="Penicillin_amidase_A-knob"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023343">
        <property type="entry name" value="Penicillin_amidase_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043146">
        <property type="entry name" value="Penicillin_amidase_N_B-knob"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002692">
        <property type="entry name" value="S45"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34218">
        <property type="entry name" value="PTHR34218"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01804">
        <property type="entry name" value="Penicil_amidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="SSF56235"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0865">Zymogen</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014624599" evidence="5">
        <location>
            <begin position="30"/>
            <end position="818"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="204"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PJN07501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="818" mass="85689" checksum="5B80278F92214DCC" modified="2018-04-25" version="1">MRTRPRRLAVIGFALLTALSTTASLPSAAAGGHGRPEHHPHGGGLSATIRFTEYGIPHIVAKDYAGLGFGTGWAQAADQVCALADGFVTVRGERSRYFGPDAAPDGSLSSATKNVSSDLYFRGVREAGTVDKLLTEPAPAGPSREVKETMRGFAAGYNAWLKQNRITDPACKGADWVRPVTTLDVAAHGFALAVLGGQGRGVDGITAAQPPTAQPPGGAGTQPPTAGTPAPTPDKATTAAAAKELFSGEDADMGSNAVAFSGATTANGRGLLLGNPHYPWQGGRRFWQSQQTIPGELNVSGGSLLGSTTISIGHNSRIAWSHTVATGVTLNLHQLTLDPADPTAYLVDGRPERMTKRTVTVAVKDGAPVTRTQWWTRYGPIVNSLGASLPLPWTATTAYALNDPNALNLRASDTGLGFSKARSTDDVLRSLKRTQGLPWVNTVAADASGHSLFAQAQVLPRITDDLAARCSTPLGKVTYPASGVAVLDGSRGDCKLGSDKDAVQPGIFGPSRMPVLKDAPYVENSNDSAWLANADRPLTGYERVFGTVGTQRSMRTRGGVEDVSAMAGRGGLTVADLQRQQFADRVPAADLAAADSARACAALPGGTATGSDGTAVDVGQACDVLKKWDHTMRTSSRGALLFDRFWRGLTAAVPNDKLWKVPFSAADPVRTPNTLNTDAPGFATALADAVGELRAAGIALDDPLGAHQFVVRGGKRIPVHGGTESLGVWNKVETVWDAKAGGYTEVVHGSSYIQAVGWNGGGCPVARTLLTYSQSSNPNSPHYSDQTHLYSDGEWVTSRFCEKDILKSPALKVVRVHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JKX5</accession>
    <name>A0A2M9JKX5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ribonuclease BN</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CG723_33865</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CB01635</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000020">
        <property type="protein sequence ID" value="PJN07525.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN07525">
        <property type="protein sequence ID" value="PJN07525"/>
        <property type="gene ID" value="CG723_33865"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017039">
        <property type="entry name" value="Virul_fac_BrkB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30213">
        <property type="entry name" value="PTHR30213"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03631">
        <property type="entry name" value="Virul_fac_BrkB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF035875">
        <property type="entry name" value="RNase_BN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00765">
        <property type="entry name" value="yihY_not_rbn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="29"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="134"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="178"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="208"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="243"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PJN07525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="290" mass="30811" checksum="7A6DC2333BD8B90F" modified="2018-04-25" version="1">MSWRRLWAALRRTPVSMWNDDVSDWAAALTYYAILALLPAMLVTASLIGLVSPATTDALITHVTAWAPAESGAALHESLRHMAHERSAALTVTIAGAVSALWSASSYSAVFRRALHTLHGVRDTRPVWRKAHRILLTACTLLALLVASALALVLSGSLAQSLGHWLGLGDTVAAAWNFLKWPALLCLVALLVLVLFRSGPPAARGWRHGLPGGLLAALIWLVASAGFTFYASQLGTYSRLYGSLAGGVVFLVWLWVSNLALLAGAQFGVELDRTAPHAPEVSAGDAAPAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JL12</accession>
    <name>A0A2M9JL12_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Probable RNA 2'-phosphotransferase</fullName>
            <ecNumber evidence="5">2.7.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">kptA</name>
        <name evidence="6" type="ORF">CG723_32890</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CB01635</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4 5">Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP-ribose 1''-2''-cyclic phosphate (APPR&gt;P). May function as an ADP-ribosylase.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the KptA/TPT1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.-" evidence="5"/>
    <dbReference type="EMBL" id="NNBL01000019">
        <property type="protein sequence ID" value="PJN07566.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN07566">
        <property type="protein sequence ID" value="PJN07566"/>
        <property type="gene ID" value="CG723_32890"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003950">
        <property type="term" value="F:NAD+ ADP-ribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016772">
        <property type="term" value="F:transferase activity, transferring phosphorus-containing groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006388">
        <property type="term" value="P:tRNA splicing, via endonucleolytic cleavage and ligation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.970">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.170.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00299">
        <property type="entry name" value="KptA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002745">
        <property type="entry name" value="Ptrans_KptA/Tpt1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042081">
        <property type="entry name" value="RNA_2'-PTrans_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022928">
        <property type="entry name" value="RNA_2'-PTrans_KptA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042080">
        <property type="entry name" value="RNA_2'-PTrans_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12684">
        <property type="entry name" value="PTHR12684"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01885">
        <property type="entry name" value="PTS_2-RNA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0520">NAD</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5 6" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00025212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PJN07566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="180" mass="19894" checksum="BAAF5F6D08C5B1DD" modified="2018-04-25" version="1">MDERRTVKVSKYLSKHLRHQPERIGLTLDEGGWVEIGTLLAAAAAHGFRITRDELDHVVAANDKRRFAIEGSRIRASQGHTVDVDLGLLPATPPAYLYHGTVASALDAIRAEGLRPMSRHDVHLSPDRETATRVGARRGRPVVLSVDAGAMHRDGHTFRVSANGVWLTEAVPPRYLRFRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-09-29" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JL56</accession>
    <name>A0A2M9JL56_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Enoyl-CoA hydratase</fullName>
            <ecNumber evidence="3">4.2.1.17</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_34035</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the enoyl-CoA hydratase/isomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.17" evidence="3"/>
    <dbReference type="EMBL" id="NNBL01000020">
        <property type="protein sequence ID" value="PJN07507.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN07507">
        <property type="protein sequence ID" value="PJN07507"/>
        <property type="gene ID" value="CG723_34035"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004300">
        <property type="term" value="F:enoyl-CoA hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.12.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014748">
        <property type="entry name" value="Enoyl-CoA_hydra_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN07507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="278" mass="29749" checksum="4BB6B4D240D4A1C9" modified="2018-04-25" version="1">MDGTEHDAGHGTGHGTEHLAVRREGATLVLTLNRPEAKNALSLPMLVGLYDGWVAADEDDSIRSVVLTGAGGTFCAGMDLKALAGKGMEGEQYRDRLKADPDLHWKAMLRHHRPRKPVIAAVEGYCVAGGTEILQGTDIRVAAESATFGLSEVKRALFPIGGSTVRLQRQIPRTHALEMLLTGRHYSAAEALSIGLIGSVVPTGTALDKALEIAEQVNACGPLAVEAVKASVYETAEMTETDGLKSELERGWPIFATEDAKEGPRAFAEKRPAVYRRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JME2</accession>
    <name>A0A2M9JME2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_30655</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000016">
        <property type="protein sequence ID" value="PJN08045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08045">
        <property type="protein sequence ID" value="PJN08045"/>
        <property type="gene ID" value="CG723_30655"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="23"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="137"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="206"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="233"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN08045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="261" mass="28198" checksum="B9FDB334BF7B2676" modified="2018-04-25" version="1">MDPAGLRALVTARGRRATVSEGAFVGGPFLLFVPVAFCAALLSQARTVLELAALRGGDPAADDRAAELLVLQGVHENPVRAREALAVCHGEHSAICKRRSALRHPVVLWNLTLRMARVLGLLTAPERTGWSRRLVQAGRWVLLGLVFVVGVVAPLVWLPYMAMSYYQATTRLTDRATAFYFTDSALVARRRSHLDPASLAGAARTLLSLLVPVALVAATLVTGVRIADSSWPVVGILLFTASVAAGAMWHWRRRRHRTSGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JMT2</accession>
    <name>A0A2M9JMT2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_29605</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000015">
        <property type="protein sequence ID" value="PJN08164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08164">
        <property type="protein sequence ID" value="PJN08164"/>
        <property type="gene ID" value="CG723_29605"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="34"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="95"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="158"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="185"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="245"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN08164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="275" mass="31602" checksum="E281C61C89CF5B0C" modified="2018-04-25" version="1">MATGTEPHPRPDAHGVRDRTRAAIASGHLRTDRWWLAPASTAAGLLAFIVYSTWRAFANTDYYHAPYVSPFYSPCIAENCKPMHAGPNWEIFGGWWGLSPALLILIFPLGFRLTCYYYRKAYYRGFWASPPACAVAEPHKKYTGETRFPLILQNIHRYFFYAAILVAGILTYDTVLSFRNEKYEWGHMGLGTLVFLLNITLIWAYTLSCHSCRHIVGGKLKHFSKHPVRYRMWQWVGKLNDRHMLLAWASLISVALADFYVFLLSSGAFDDPRFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JN45</accession>
    <name>A0A2M9JN45_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Peptidoglycan glycosyltransferase</fullName>
            <ecNumber evidence="1">2.4.1.129</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CG723_28225</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CB01635</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>[GlcNAc-(1-&gt;4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)](n)-di-trans,octa-cis-undecaprenyl diphosphate + beta-D-GlcNAc-(1-&gt;4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate = [GlcNAc-(1-&gt;4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)](n+1)-di-trans-octa-cis-undecaprenyl diphosphate + di-trans,octa-cis-undecaprenyl diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23708"/>
            <dbReference type="Rhea" id="RHEA-COMP:9602"/>
            <dbReference type="Rhea" id="RHEA-COMP:9603"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58405"/>
            <dbReference type="ChEBI" id="CHEBI:60033"/>
            <dbReference type="ChEBI" id="CHEBI:78435"/>
            <dbReference type="EC" id="2.4.1.129"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.129" evidence="1"/>
    <dbReference type="EMBL" id="NNBL01000014">
        <property type="protein sequence ID" value="PJN08291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08291">
        <property type="protein sequence ID" value="PJN08291"/>
        <property type="gene ID" value="CG723_28225"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004180">
        <property type="term" value="F:carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008658">
        <property type="term" value="F:penicillin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008955">
        <property type="term" value="F:peptidoglycan glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3810.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001264">
        <property type="entry name" value="Glyco_trans_51"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023346">
        <property type="entry name" value="Lysozyme-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036950">
        <property type="entry name" value="PBP_transglycosylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001460">
        <property type="entry name" value="PCN-bd_Tpept"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00912">
        <property type="entry name" value="Transgly"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00905">
        <property type="entry name" value="Transpeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53955">
        <property type="entry name" value="SSF53955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Transgly" evidence="10">
        <location>
            <begin position="77"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="domain" description="Transpeptidase" evidence="9">
        <location>
            <begin position="362"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="677"/>
            <end position="743"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="686"/>
            <end position="707"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="709"/>
            <end position="723"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PJN08291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="743" mass="79094" checksum="487200A0AC47F0BC" modified="2018-04-25" version="1">MGKKRSGGGLSPTQQAAKFLGVSVLAGAVLAGIALPAAGALGLAAKGSVEGFDEIPANLKQPPLSQRTTILDNKGGAIATVYSRDRTVVPLKDISPYMQKALVAIEDSRFYEHGAVDVKGILRAINENAQSGGVAQGASTLTQQYVKNVFMEEAGDDPTKLAQATQQTIGRKIRELKYAIQLEDKLGKKRILANYLNITYFGEQAYGVEAASRRYFSKSAKDLTVEESAMLAGIVQSPSRYDPVNDEAEATKRRNVVLQRMAETHDISQAEADRAKEKPLGLKISKPQNGCITAVKGAGFFCDYVREVFLTDPVFGKTKEARAKLWNRGGLRVQTTLDPQTQESVQASIKDHVYQTDKVATAATFIEPGTGKILGMGQSKPYGFGKNETQINYSVDRKMSGSNFGFPTGSTFKPFLAAAALEQGTPVTKSYPAPYRMPYPKSVQTCSGKPWVNNSGFTVENENESEFGPYALEEAMAKSINTYFVQMIGDTGMCPVMDMADKLGVVQGNGDKLPEVPAIVLGSKGISPLTMASAYAAFANRGTYCTPVAIESITAPGDKSLPVPKSSCSRAMTTKTADSINTLLSGVIDSGTGREAGLTDRANAGKTGTTDSRKNAWFVGYTPNLSGAVWVGSALQNVEMENITIGGQYQPKVFGGQVPGPIWKDAMVGALADKPSPDFNLIDIPDPETDEDRDHDRDHDRDEEPGQGGSKPGTNSGGNGNSPWPGLPTGLLGGGNGHGGGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JN70</accession>
    <name>A0A2M9JN70_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_28285</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000014">
        <property type="protein sequence ID" value="PJN08300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08300">
        <property type="protein sequence ID" value="PJN08300"/>
        <property type="gene ID" value="CG723_28285"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018334">
        <property type="entry name" value="ArsR_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001845">
        <property type="entry name" value="HTH_ArsR_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01022">
        <property type="entry name" value="HTH_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00778">
        <property type="entry name" value="HTHARSR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00418">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00846">
        <property type="entry name" value="HTH_ARSR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50987">
        <property type="entry name" value="HTH_ARSR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH arsR-type" evidence="1">
        <location>
            <begin position="27"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN08300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="133" mass="14189" checksum="A2FDFC130605428A" modified="2018-04-25" version="1">MSKQELVVLDQTADEHGCCPRLLTAPLDENQAVELAKVFKALGDPVRLRLLSMIASSEGGEICVCDLTPAFGLSQPTISHHLKLLRQAGLIDSERRGTWVYYWLVPEMTDKLAGILTRPAGTAAAAGSAGSAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JNC7</accession>
    <name>A0A2M9JNC7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_28715</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000014">
        <property type="protein sequence ID" value="PJN08369.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08369">
        <property type="protein sequence ID" value="PJN08369"/>
        <property type="gene ID" value="CG723_28715"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014974286" evidence="2">
        <location>
            <begin position="32"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="25"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="29"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN08369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="102" mass="8871" checksum="4702D445F4C72F2A" modified="2018-04-25" version="1">MRAVIIGAIIFVLVVVGIVVAVSSAGGSGKARSGKTSLSKGRSSRSSGSWWAGGGGAAGGASCSSGGSGGHHGHSCGGGSSCGGGSSCGGGGGGGGCGGGGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JNG8</accession>
    <name>A0A2M9JNG8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">AMP-dependent synthetase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_28965</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000014">
        <property type="protein sequence ID" value="PJN08411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08411">
        <property type="protein sequence ID" value="PJN08411"/>
        <property type="gene ID" value="CG723_28965"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-binding" evidence="1">
        <location>
            <begin position="12"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding_C" evidence="2">
        <location>
            <begin position="417"/>
            <end position="492"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN08411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="511" mass="55351" checksum="D6C47E5E7754130F" modified="2018-04-25" version="1">MFVPFGALDFLERAATVYGDRIGVVDEPVQPAEPWEDLTYRRVAELARAQAAGLDALGVPLGARVAVVSPNSARLLTSFFGVSGYGRVLVPVNFRLTAEEVSYVVSHSGADVLLVDPELTDRLAQVPAKHRFTIGAAADSELYRFDADPGDWTPDENATATINYTSGTTARPKGVQITHRNIWVNAVTFALHAGVTDRDVYLHTLPMFHANGWGMPFAMSALGVRQIALRKVDGAEILRRVAEHGVTVMCAAPAVVNAVLDAARSWKGAIPGRDRVRIIVAGAPPPTRTVARVESELGWEFIQIYGLTETSPLLTVNRGRAEWDELDASERAEKLVRAGAPALGVTLRTDEEGEVLARSNVILEGYWEQPEESAKALAGGWFHTGDGGAVGEDGYLTISDRKKDVIITGGENVSSIEVEDALFSHSGVAEVAVIGVPHEKWGETIKALVVLSPDATVTEDELIRHCKARLAGFKAPTSVEFREELARTATGKLQKYKLRAPYWEGRDRGVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JNI0</accession>
    <name>A0A2M9JNI0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_29020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000014">
        <property type="protein sequence ID" value="PJN08420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08420">
        <property type="protein sequence ID" value="PJN08420"/>
        <property type="gene ID" value="CG723_29020"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="59"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="89"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="111"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN08420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="138" mass="14670" checksum="C6225BBCA25B6719" modified="2018-04-25" version="1">MAHAAPVSGTSGLRSMAAGSRLPMALSLLLGIVYGFWASGIRRDAVPSLSPSPITTGNVLFGVLTGVIVAVVTFGIHRASFRLPRELRAVAWAAWAGIAFGYLYSLTDASVLRSTIMALTVAAGVFATMFYRYYTHEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JNK9</accession>
    <name>A0A2M9JNK9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DNA-binding response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CG723_29190</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000014">
        <property type="protein sequence ID" value="PJN08451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08451">
        <property type="protein sequence ID" value="PJN08451"/>
        <property type="gene ID" value="CG723_29190"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00622">
        <property type="entry name" value="HTH_LUXR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="8"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="domain" description="HTH luxR-type" evidence="3">
        <location>
            <begin position="150"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PJN08451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="220" mass="23899" checksum="36C2CD18E9348668" modified="2018-04-25" version="1">MSEDGKIRVFLLDDHEVVRRGVHEMLSVEGDIEVVGEAGTAADAVVRIPATRPDVAVLDVRLPDGSGVEVCREIRSQDDSIKCLMLTSFADDEALFDAIMAGASGYVLKAIRGNELLNAVRDVAAGKSLLDPVATARVLERLRGGGRGKEDDRLASLTEQERKILDLIGEGLTNRVIGERLHLAEKTIKNYVSSLLSKLGMARRSQAAAYVARLQAEKRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JNL7</accession>
    <name>A0A2M9JNL7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">TetR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CG723_29270</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000014">
        <property type="protein sequence ID" value="PJN08464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08464">
        <property type="protein sequence ID" value="PJN08464"/>
        <property type="gene ID" value="CG723_29270"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041490">
        <property type="entry name" value="KstR2_TetR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17932">
        <property type="entry name" value="TetR_C_24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="5">
        <location>
            <begin position="8"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="4">
        <location>
            <begin position="31"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PJN08464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="196" mass="22032" checksum="1EA0D1884C898115" modified="2018-04-25" version="1">MTTARRDTYTPETLLSVAVQVFNERGYDGTSMEHLSKAAGISKSSIYHHVAGKEELLRRAVSRALDGLFGILGEEHACVGRAVERLEYVTRRMVQVLISELPYVTLLLRVRGNTDAERWAMERRREFDHQVAELLKAAAADGDVRGDIEVRLATRLVFGMINSIVEWYRPGGRGMDDREVADAVVQLIFGGLRKED</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JNT1</accession>
    <name>A0A2M9JNT1_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">[Acyl-carrier-protein] S-malonyltransferase</fullName>
            <ecNumber evidence="2">2.3.1.39</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">fabD</name>
        <name evidence="6" type="ORF">CG723_27505</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CB01635</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>holo-[ACP] + malonyl-CoA = CoA + malonyl-[ACP]</text>
            <dbReference type="Rhea" id="RHEA:41792"/>
            <dbReference type="Rhea" id="RHEA-COMP:9623"/>
            <dbReference type="Rhea" id="RHEA-COMP:9685"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57384"/>
            <dbReference type="ChEBI" id="CHEBI:64479"/>
            <dbReference type="ChEBI" id="CHEBI:78449"/>
            <dbReference type="EC" id="2.3.1.39"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.39" evidence="2"/>
    <dbReference type="EMBL" id="NNBL01000013">
        <property type="protein sequence ID" value="PJN08529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08529">
        <property type="protein sequence ID" value="PJN08529"/>
        <property type="gene ID" value="CG723_27505"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004314">
        <property type="term" value="F:[acyl-carrier-protein] S-malonyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd04742">
        <property type="entry name" value="NPD_FabD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.366.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001227">
        <property type="entry name" value="Ac_transferase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014043">
        <property type="entry name" value="Acyl_transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004410">
        <property type="entry name" value="Malonyl_CoA-ACP_transAc_FabD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016036">
        <property type="entry name" value="Malonyl_transacylase_ACP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014179">
        <property type="entry name" value="PfaD_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00698">
        <property type="entry name" value="Acyl_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00827">
        <property type="entry name" value="PKS_AT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="SSF52151"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55048">
        <property type="entry name" value="SSF55048"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00128">
        <property type="entry name" value="fabD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02814">
        <property type="entry name" value="pfaD_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PKS_AT" evidence="5">
        <location>
            <begin position="5"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="314"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="324"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PJN08529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="795" mass="84513" checksum="450914FC58A3DFF2" modified="2018-04-25" version="1">MVALVFPGQGSQRKGMGADLFARFPDLTRQADTVLGHSVEELCRTSGDGRLDRTEYAQPALFVVSALSYLARDPGLPQPALLAGHSLGEYGALFAAGCFDFATGVRLVRERGALMGRAQGGGMLAVLGVDGDEVQALLAGTGARQVDVANYNTPTQTVLSGPLDELRMVSAALGQRPGVRCVPVRVSAAFHSRHMRPAAQEFATFLTGFSFADPHRTVISSVTARPYGAGQVAELLSRQIESPVRWSETMAYLRERGTTELEEMGPGKVLTGLWKQGRADGAKARAVAPAPVAVAAGVPAAAAARTPASSAPVAARAATAAPARPSDPAPPAPRTAPSPASPVPPASVSRGQRAEELGSAEFRRDYGIRYAYLAGAMFRGIASAELVIRMGRAGLMGFFGAGGLGLDKVESALVRIKDALGPDGRYGMNLLHSIDDPAYEHAVVDLCLKHGVHDVEAAGFTQLTPAVVQFRFSGAHRDAVGRPVAVRRVLAKVSRPEVAAAFMAPAPAAILRRLTADGRLTPQEAEIAAELPVGQDICVEADSGGHTDGGAALTLLPSMIRHRDAAMARHGYGRRIRIGAAGGIGAPEAVAAAFVLGADFVLTGSVNQCSPEAGTSDAVKDILAGLDVQDTAYAPAGDMFEIGARVQVVRKGTLFAARGNKLYQLYRSHDSWESIDAGTRRSVEETYFKRPFAEVWEETRVYHLGRGRDAEIEKADRLPKHRMALAFRWYFARSVRWGLEGEPTQKVNYQIQCGPAIGAFNHVVRGTGLEDWRHRHVDLIAEHLMTGAADVLARR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JP21</accession>
    <name>A0A2M9JP21_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Hydrogenase expression/formation protein HypE</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">hypE</name>
        <name evidence="4" type="ORF">CG723_27565</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CB01635</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HypE family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000013">
        <property type="protein sequence ID" value="PJN08621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08621">
        <property type="protein sequence ID" value="PJN08621"/>
        <property type="gene ID" value="CG723_27565"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02197">
        <property type="entry name" value="HypE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.650.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011854">
        <property type="entry name" value="HypE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010918">
        <property type="entry name" value="PurM-like_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036676">
        <property type="entry name" value="PurM-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016188">
        <property type="entry name" value="PurM-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036921">
        <property type="entry name" value="PurM-like_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30303">
        <property type="entry name" value="PTHR30303"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00586">
        <property type="entry name" value="AIRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02769">
        <property type="entry name" value="AIRS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005644">
        <property type="entry name" value="Hdrgns_mtr_HypE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55326">
        <property type="entry name" value="SSF55326"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56042">
        <property type="entry name" value="SSF56042"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02124">
        <property type="entry name" value="hypE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AIRS" evidence="2">
        <location>
            <begin position="46"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="domain" description="AIRS_C" evidence="3">
        <location>
            <begin position="160"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PJN08621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="335" mass="35513" checksum="EB289602F39665AE" modified="2018-04-25" version="1">MDQEIVLDHGTGARLSRELVEFVVEVLGDVYLGEMEDSAILPPLNGALAMTTDSFVVDPPFFGNGDIGKIAVCGTVNDLAVAGAEPRYLTLAMILESGFPLSGLHRALESVRDTAREAGIKIVAGDTKVVGEGEADGIFLNTTGVGVFTSPPKRMKDVAVGDKILLSGPIGDHTIHLLSVREGLGFEKNVLSDCAPLNNMIDTVRGAVPESAVRSMRDVTRGGLNAVLHEYASALGHAVRVEEEALPISFETAMAADMLGINPINCANEGCLALFVAPEHADEVLRVLRSHPYGKDAVIVGEVTARPEPVVEMAGKDGRIQEIEELQGAELPRLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JP29</accession>
    <name>A0A2M9JP29_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Enoyl-CoA hydratase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CG723_27510</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000013">
        <property type="protein sequence ID" value="PJN08620.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08620">
        <property type="protein sequence ID" value="PJN08620"/>
        <property type="gene ID" value="CG723_27510"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PJN08620.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="262" mass="28036" checksum="77E90BF0EE541045" modified="2018-04-25" version="1">MGPTHRGVRLTAEPHVLRATLTSPDGLNSLSGDALDALGAALDRAEADPECRVLLLEGSGGTFCTGLDFEEAAGDAAGGASQAGRGGAEFLALMRRFGETPLAVVACVDGRAAGGGVGLAAAADLVIATERSEFSLPEALWGLVPCCVLPVLVRRTGFQPAYAMALSTQPVSARRAADFRLVDEVVPDPDAAVRRLLVRLTRLDPATIGELKQYFRAMWFTTEDTDAFALREFTRLIDSPVARRRITDYTTTRRLPWEKPRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JP80</accession>
    <name>A0A2M9JP80_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GNAT family N-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_26665</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000012">
        <property type="protein sequence ID" value="PJN08682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08682">
        <property type="protein sequence ID" value="PJN08682"/>
        <property type="gene ID" value="CG723_26665"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13673">
        <property type="entry name" value="Acetyltransf_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="7"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN08682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="157" mass="17947" checksum="BE24C5825EAC8BBC" modified="2018-04-25" version="1">MSDDGKTRIRCAAEADAGVIARIHMTSRSATMPYLPPQKRNHEQVTRWVRDILLKQCRTWVAVRDAEIAGYAALDGDVLEDLYLRPDVRRQGIGTLLLDEVRRHSPEGVSLHVFQQNTEARAFYKRHGFTVLDTSDGDRNMENLPDMTLRWTPDSAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JPJ3</accession>
    <name>A0A2M9JPJ3_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Bifunctional protein GlmU</fullName>
        </recommendedName>
        <domain>
            <recommendedName>
                <fullName evidence="15">UDP-N-acetylglucosamine pyrophosphorylase</fullName>
                <ecNumber evidence="15">2.7.7.23</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="15">N-acetylglucosamine-1-phosphate uridyltransferase</fullName>
            </alternativeName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="15">Glucosamine-1-phosphate N-acetyltransferase</fullName>
                <ecNumber evidence="15">2.3.1.157</ecNumber>
            </recommendedName>
        </domain>
    </protein>
    <gene>
        <name evidence="15 18" type="primary">glmU</name>
        <name evidence="18" type="ORF">CG723_27330</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">CB01635</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP-GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5-monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>H(+) + N-acetyl-alpha-D-glucosamine 1-phosphate + UTP = diphosphate + UDP-N-acetyl-alpha-D-glucosamine</text>
            <dbReference type="Rhea" id="RHEA:13509"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
            <dbReference type="ChEBI" id="CHEBI:57776"/>
            <dbReference type="EC" id="2.7.7.23"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>acetyl-CoA + alpha-D-glucosamine 1-phosphate = CoA + H(+) + N-acetyl-alpha-D-glucosamine 1-phosphate</text>
            <dbReference type="Rhea" id="RHEA:13725"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:57776"/>
            <dbReference type="ChEBI" id="CHEBI:58516"/>
            <dbReference type="EC" id="2.3.1.157"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="15">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="15">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="15">Bacterial outer membrane biogenesis; LPS lipid A biosynthesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="15">Nucleotide-sugar biosynthesis; UDP-N-acetyl-alpha-D-glucosamine biosynthesis; N-acetyl-alpha-D-glucosamine 1-phosphate from alpha-D-glucosamine 6-phosphate (route II): step 2/2.</text>
    </comment>
    <comment type="pathway">
        <text evidence="15">Nucleotide-sugar biosynthesis; UDP-N-acetyl-alpha-D-glucosamine biosynthesis; UDP-N-acetyl-alpha-D-glucosamine from N-acetyl-alpha-D-glucosamine 1-phosphate: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="15">Homotrimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 15">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 15">In the C-terminal section; belongs to the transferase hexapeptide repeat family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 15">In the N-terminal section; belongs to the N-acetylglucosamine-1-phosphate uridyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.23" evidence="15"/>
    <dbReference type="EC" id="2.3.1.157" evidence="15"/>
    <dbReference type="EMBL" id="NNBL01000012">
        <property type="protein sequence ID" value="PJN08791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08791">
        <property type="protein sequence ID" value="PJN08791"/>
        <property type="gene ID" value="CG723_27330"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00113">
        <property type="reaction ID" value="UER00532"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00973"/>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019134">
        <property type="term" value="F:glucosamine-1-phosphate N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003977">
        <property type="term" value="F:UDP-N-acetylglucosamine diphosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000902">
        <property type="term" value="P:cell morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009245">
        <property type="term" value="P:lipid A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006048">
        <property type="term" value="P:UDP-N-acetylglucosamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd03353">
        <property type="entry name" value="LbH_GlmU_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01631">
        <property type="entry name" value="GlmU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005882">
        <property type="entry name" value="Bifunctional_GlmU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038009">
        <property type="entry name" value="GlmU_C_LbH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001451">
        <property type="entry name" value="Hexapep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025877">
        <property type="entry name" value="MobA-like_NTP_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00132">
        <property type="entry name" value="Hexapep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12804">
        <property type="entry name" value="NTP_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="SSF51161"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01173">
        <property type="entry name" value="glmU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13 15" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="10 15" id="KW-0133">Cell shape</keyword>
    <keyword evidence="14 15" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="4 15" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 15" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12 15" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="6 15" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="11 15" id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 15" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 15 18" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="NTP_transf_3" evidence="17">
        <location>
            <begin position="11"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Pyrophosphorylase" evidence="15">
        <location>
            <begin position="1"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="region of interest" description="UDP-GlcNAc binding" evidence="15">
        <location>
            <begin position="14"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="region of interest" description="UDP-GlcNAc binding" evidence="15">
        <location>
            <begin position="86"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Linker" evidence="15">
        <location>
            <begin position="241"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="region of interest" description="N-acetyltransferase" evidence="15">
        <location>
            <begin position="262"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="region of interest" description="Acetyl-CoA binding" evidence="15">
        <location>
            <begin position="396"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="462"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="15">
        <location>
            <position position="373"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="28"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-glucosamine</name>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="81"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-glucosamine</name>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="112"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="149"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-glucosamine</name>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="165"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-glucosamine</name>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="180"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-glucosamine</name>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="238"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="343"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-glucosamine</name>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="361"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-glucosamine</name>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="376"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-glucosamine</name>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="387"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-glucosamine</name>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="390"/>
        </location>
        <ligand>
            <name>acetyl-CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="415"/>
        </location>
        <ligand>
            <name>acetyl-CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="433"/>
        </location>
        <ligand>
            <name>acetyl-CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="450"/>
        </location>
        <ligand>
            <name>acetyl-CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF12804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="PJN08791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="484" mass="50113" checksum="257FA53CF2EEEA5E" modified="2018-04-25" version="1">MSANSPRPAAVVVLAAGEGTRMKSATPKVLHEISGRSLVGHVLAAARELSPENLVVVVGHERDRVREHLAGIDPDARTAVQEQQNGTGHAVRMGLEELGGVVEGTVIVVCGDTPLLTGETLTHLSATHTGDGNAVTVLTAEVPDATGYGRIVRDGASGAVTAIVEHKDASESQHAIREINSGVFAFDGALLADALGKVRTDNSQGEEYLTDVLGILREAGHRVGASVAADHREIAGINNRVQLAEARRTLNDRLLERAMLAGVTIVDPASTWVDVTVGFERDAIVHPGTQLLGASWLGEGAEVGPNTRLRDTRVGAGARVDNTVADGAEVGEGASVGPFAYLRPGTRLGLRAKIGTYVETKNSTIGEGTKVPHLSYVGDATIGDYTNIGAASVFVNYDGEAKHHTTVGSHCKTGSDNMFVAPVTVGDGAYTAAGSVITKDVPAGSLAVARGQQRNIEGWVARKRPGSAAAKAAEEASREAGSNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JQ00</accession>
    <name>A0A2M9JQ00_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Superoxide dismutase, Ni</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">sodN</name>
        <name evidence="1" type="ORF">CG723_26050</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000011">
        <property type="protein sequence ID" value="PJN08948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08948">
        <property type="protein sequence ID" value="PJN08948"/>
        <property type="gene ID" value="CG723_26050"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016151">
        <property type="term" value="F:nickel cation binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004784">
        <property type="term" value="F:superoxide dismutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.400">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036502">
        <property type="entry name" value="NiSOD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014123">
        <property type="entry name" value="Superoxide_dismutase_Ni-type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09055">
        <property type="entry name" value="Sod_Ni"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109770">
        <property type="entry name" value="SSF109770"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02753">
        <property type="entry name" value="sodN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PJN08948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="131" mass="14628" checksum="06D6BAAD276AEDA5" modified="2018-04-25" version="1">MLSRLFAPKVKASAHCDLPCGVYDPAQARIEAESVKAVQEKMAGNDDPQFQTRAIVIKEQRAELAKHHVSVLWSDYFKPPHFEKYPELSQLVNDTLKALSAAKASSDPATGQKALDYIAQIDKIFWETKKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JQ41</accession>
    <name>A0A2M9JQ41_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Sodium:solute symporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CG723_26215</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CB01635</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000011">
        <property type="protein sequence ID" value="PJN08980.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08980">
        <property type="protein sequence ID" value="PJN08980"/>
        <property type="gene ID" value="CG723_26215"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1730.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038377">
        <property type="entry name" value="Na/Glc_symporter_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001734">
        <property type="entry name" value="Na/solute_symporter"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00474">
        <property type="entry name" value="SSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50283">
        <property type="entry name" value="NA_SOLUT_SYMP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="49"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="75"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="128"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="168"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="199"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="256"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="294"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="337"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="386"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="411"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="440"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="481"/>
            <end position="503"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU362091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PJN08980.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="543" mass="57662" checksum="8D595405F30E1EE8" modified="2018-04-25" version="1">MNGGVNGVALGVFIFFFIAVTVMGFLAARWRRSDNEQSLDEWGLGGRSFGTWVTWFLLGGDLYTAYTFVAVPAAIYAAGASGFFAVPYTILVYPLIFTFLPRLWSVSHKHGYVTTSDFVRGRFGSKGLSLAVAVTGILATMPYIALQLVGIQAVLDVMGVGGDESTNWFIKDLPLLIAFAVLAAYTYSSGLRAPALIAFVKDGLIYLVIAVAIIYIPIKLGGFDAIFHAANEKFATPNPATGKPVGSLAPAPAGQWTYATLALGSALALFMYPHSITATLSSRSRNVIRRNTTILPLYSLMLGLLALLGFMAIAAGIKVQNGQLAIPQLFEDMFPDWFTGVAFAAIGIGALVPAAIMSIAAANLFTRNIYKDFIKPDATPEQETKVSKLVSLLVKVGALAFVLTMDKTVAINFQLLGGIWILQTMPALVGGLFTRWFHRWALLAGWAVGMVYGTLAAYGVASPTQKHFGGSAKEIPGIGEIGYIGLTAFVMNVVVTVVLTFVLKALKAPEGIDETSAADYTADAGDPGVLKKLPEATAGAGGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JQC2</accession>
    <name>A0A2M9JQC2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Serine protease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_24350</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000010">
        <property type="protein sequence ID" value="PJN09064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN09064">
        <property type="protein sequence ID" value="PJN09064"/>
        <property type="gene ID" value="CG723_24350"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001940">
        <property type="entry name" value="Peptidase_S1C"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00834">
        <property type="entry name" value="PROTEASES2C"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="SSF50494"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="76"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="248"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="29"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN09064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="363" mass="36006" checksum="680024C5BF3840F9" modified="2018-04-25" version="1">MTESFRRSGEYPQGQQQHSQSSYPGTPEAGGAFPPPPAYDPPQPVNAAPGSAMWPAPVPEGSPAPPARRRRVKGPLGLLAAVAIAAAAVGGGTAYAFQELTGKDSTSTSAGASVVPTSKKGTVAGVAEAVSPAIVEISATSNAGSSTGSGVVITSDGEIVTNNHVVSGASTVKVRTNDGKTYTADVVGTDAKKDLALIKLKNASGLKTASLGDSDNVKVGDEVVAIGSPEGLTGTVTSGIVSALDRDVTVSTDEEQQQQQGGGSDGQWPFEFGGQQFNGDTGSSKTTYKALQTDASLNPGNSGGALIDMNGNIIGINSAMYSASSDSGSGSSGAGSVGLGFAIPVNTVKADLDSLRSGGTSGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JQN6</accession>
    <name>A0A2M9JQN6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CG723_25050</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000010">
        <property type="protein sequence ID" value="PJN09180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN09180">
        <property type="protein sequence ID" value="PJN09180"/>
        <property type="gene ID" value="CG723_25050"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PJN09180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="121" mass="12933" checksum="8F7C6F4CB3E8425A" modified="2018-04-25" version="1">MEISPLEQALHAARALVLADLGSGEIAHADVVSLVEDSIVHRRWWVEQWPEGIEYVAGLVAQDVQDGLLERSGRWPLCPVCGSGEPHALDVEPELGPDPHWVCSEAGVVVAPVGSLGTVAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JQY8</accession>
    <name>A0A2M9JQY8_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CG723_23410</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CB01635</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="NNBL01000009">
        <property type="protein sequence ID" value="PJN09300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN09300">
        <property type="protein sequence ID" value="PJN09300"/>
        <property type="gene ID" value="CG723_23410"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004673">
        <property type="term" value="F:protein histidine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033463">
        <property type="entry name" value="sCache_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029151">
        <property type="entry name" value="Sensor-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13185">
        <property type="entry name" value="GAF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17203">
        <property type="entry name" value="sCache_3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07228">
        <property type="entry name" value="SpoIIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00065">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00331">
        <property type="entry name" value="PP2C_SIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103190">
        <property type="entry name" value="SSF103190"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="SSF81606"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="40"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="207"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="domain" description="PAS" evidence="6">
        <location>
            <begin position="249"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="domain" description="GAF" evidence="5">
        <location>
            <begin position="369"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="domain" description="PPM-type phosphatase" evidence="7">
        <location>
            <begin position="562"/>
            <end position="787"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PJN09300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="938" mass="100128" checksum="83F5AEB83FEF38F4" modified="2018-04-25" version="1">MKGFSSPKRHESHRLFTGPASGHGESAGSGLRSLLNLRSVAGQVFVMQVVIVVLLVAAAVTALVLQAGRASTREAERQSLTAAEAFANAPGTVQALNSKDPTAVLQPRAEAARKRAGVTFIVVLDTNGIRYTHPDPKRIGKKFIGTIKPSLEGRTTIERARGLPLAEGSGPVIQAVVPVTDDRGSVVGLVSAGIKVRKVTALSARQMPIIFGAGAAALALSTLGTALVARRLRGQTHGLGPAEMTRMYEHHDAVLHAAREGVLIIGADGRLMLANDEARRLLELPADAEQRQVAELKLDADTARLLTSGEATTDEVHRAGDRLLAVNMRPTAPFGGQAGWVVTLRDTTELAVVTGRAEVARERLTLLYDAGVRIGTTLDVVRTAQELADVATPRFADIVTVDLLESVERGEEPTRTADVRRTVISEGYQEREGIYPVGQLITYSPTAPQARALETGRAVLEDDLRQAWGWREQDPDGASRALARGVHSLVTAPLQARGVVLGTTNFWRTGDSPPFKEEDLSFAEELAARAAVAIDNARRFTREHTMAVTLQRSLLPQGVPEQDALEVAWRYLPAEAGVGGDWFDVIPLPGARVALVVGDVVGHGLHAAATMGRLRTAVQNFSALDLPPDELLGHLDELVTRIDSDESTDDGPQGRQSEAVTGATCLYAIYDPATRVCTTARAGHPGPAVVDPDGTVTSPEVPASPPLGLGGHPFETTELRLPEGSRLVLYTDGLIVNRDRDIDTGLALLHQALEGAGRTPDETCQAAIDAMLPAHPADDIALLVARTRLLEPSRVAHWEVPPDPAAVAPVRAECGAQLQAWGLGDIGFTTELILSELITNAIRYGSPPIRVRLLHCRSLICEVSDGSSTSPHVRRAATTDEGGRGLFLVAQFAQRWGTRYTPDGKVIWAEQSLHDGAAAPMSDTLTEALLDQFDKPTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JR01</accession>
    <name>A0A2M9JR01_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_23415</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000009">
        <property type="protein sequence ID" value="PJN09301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN09301">
        <property type="protein sequence ID" value="PJN09301"/>
        <property type="gene ID" value="CG723_23415"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="45"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN09301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="88" mass="9123" checksum="1EC4A20BA6023A9F" modified="2018-04-25" version="1">MGQAQDEKADGAHGAGAPCLLRLAGLGVLPVHQVAVPAQHVSGWTSSGSRWGLGGEWGQQRGEEGPLLGPRRRLVGAEMAFQEGDLVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JR43</accession>
    <name>A0A2M9JR43_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alpha/beta hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_23170</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000009">
        <property type="protein sequence ID" value="PJN09257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN09257">
        <property type="protein sequence ID" value="PJN09257"/>
        <property type="gene ID" value="CG723_23170"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="43"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN09257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="295" mass="31348" checksum="643B779B3C4A6CE0" modified="2018-04-25" version="1">MTQRSLLQSALADLADVPATSRWIWSGSVRLHALDYGGDLPPLVVLPGITSPAITMDFIARELTDLVRPVVLDVRGRGLSDDAPGHTLEAYAEDVEALITGLGLEHPLLFGHSMGARIAAVTAVRAKVPLGGAVLADPPMSGPGRDAYPTSLCTFLRQLAEAHRGTDADEVAGHWPTWPRHEQELRARWLSSCTREAVTGTHHGFENEDFFTWWPQVPAPLALLHGADSPVVTSAGAAEAAEANPAASVHRIPDAGHMIFWDAPTTAVAALRTALRGMLTGREPGSDAVVKCGHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JR51</accession>
    <name>A0A2M9JR51_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="12">ABC transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CG723_23540</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">CB01635</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000009">
        <property type="protein sequence ID" value="PJN09322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN09322">
        <property type="protein sequence ID" value="PJN09322"/>
        <property type="gene ID" value="CG723_23540"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025966">
        <property type="entry name" value="OppC_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12911">
        <property type="entry name" value="OppC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="33"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="99"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="133"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="159"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="265"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="11">
        <location>
            <begin position="95"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="10">
        <location>
            <begin position="326"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="361"/>
            <end position="368"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PJN09322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="598" mass="63422" checksum="4F51983ED93F838C" modified="2018-04-25" version="1">MSEKLPADPAPTAKTPADPGRSRGILRQLVRNPLGAVSLTVLLLLVAAMLLAPLLAPQAPGDASLADAFAAPSSGHPLGMDSAGRDILSRILYGGRNTLGGAVIALGIALTLGIPLGLYAGYYGGRFDSVANWLVNLVMALPAMVVLLASRAILGPNVWVLMVVLGFLASPSFFRLVRGIVANVRGELYVDAARVSGLSDTRIVARHVLTVVRGPIIIQVALVAGIAIALQAGLEFLGVGSGDSATWGAMLNEAFQNIQRRPVLLLWPGLALGLTNAALVLIATALRDSLEDRAGQPPRRTRTPGRTADFVAPADTGEERAGLLSIRSLAVSYPGPRGSDKEVVHEVDLDVRPGEIVGLVGESGSGKTQTAFSVLGIFPEGGRISRGSVLIAGREVVGMLERDHRALRGTTVAYIPQEPMSNLDPAFTIGSQLIEPMRHVLGLSRKQAAERAVDLLHTVEIPNPEQAMRRYPHEISGGMAQRVLIAGAMSCDPALLIADEPTTALDVRVQAEVLDLLRRLQQERNLGVLLVTHNLGVVADLCDRVAVMNKGRIVETGTTEQVLHAPQDDYTRTLLDAVLDTAPAREPWQPREARSTTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JR60</accession>
    <name>A0A2M9JR60_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_23810</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000009">
        <property type="protein sequence ID" value="PJN09359.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN09359">
        <property type="protein sequence ID" value="PJN09359"/>
        <property type="gene ID" value="CG723_23810"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="107"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="132"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN09359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="196" mass="20885" checksum="3FDD75EF785410ED" modified="2018-04-25" version="1">MLREMATGEPVQVTSGMSSIDKIAGLGVVAEQFGYQYVDVRRGNGYVMSLVADPGPQARARAAQNWAQYPDAVDGGALPPFVPDAFQLLKARITFDLTSEYSDKQRLIIASLGITVMVVGVVASLGADTTSFVVAGIVWVLLMCLIPVLNVAGRRYKAKYAARLAAAGFTPVTDERGRLRYLPPGGQLPGHGNPFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JR89</accession>
    <name>A0A2M9JR89_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Peptidase M4 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CG723_23840</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">CB01635</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000009">
        <property type="protein sequence ID" value="PJN09362.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN09362">
        <property type="protein sequence ID" value="PJN09362"/>
        <property type="gene ID" value="CG723_23840"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011096">
        <property type="entry name" value="FTP_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023612">
        <property type="entry name" value="Peptidase_M4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027268">
        <property type="entry name" value="Peptidase_M4/M1_CTD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001570">
        <property type="entry name" value="Peptidase_M4_C_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013856">
        <property type="entry name" value="Peptidase_M4_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07504">
        <property type="entry name" value="FTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01447">
        <property type="entry name" value="Peptidase_M4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02868">
        <property type="entry name" value="Peptidase_M4_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00730">
        <property type="entry name" value="THERMOLYSIN"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014689685" evidence="9">
        <location>
            <begin position="41"/>
            <end position="948"/>
        </location>
    </feature>
    <feature type="domain" description="FTP" evidence="12">
        <location>
            <begin position="104"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M4" evidence="10">
        <location>
            <begin position="289"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M4_C" evidence="11">
        <location>
            <begin position="455"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="43"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="45"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="active site" evidence="7">
        <location>
            <position position="445"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="7">
        <location>
            <position position="536"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR623612-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF02868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF07504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PJN09362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="948" mass="99043" checksum="6F9DFD403F6A4FB9" modified="2018-04-25" version="1">MRTSARRTTDRVRGIAVGQGVAALLAAAGLLVTAMPAAHADTDTPAAASSVSPGDDTDTPSLVTGLNESADASASAADAAREHLAGKKGRYHIADAKGDLKAVSTEDAKGGLETVRLQQKYKGVSVLGGEYVVRMTKKDGKRTVTGTSGKYFTQLKLDTVTPKVSEDVAVERAIGAVTSQLGGAPLHAPAKGDKSAKVELTGKAVGVTVLPQGTGVLTRHITVTGTNPADGTAVKQEVYVDAHSGFPVMQYSGIQTFGSTAGASGAADGAATLPDDATPTAAPPFVVKGSGTRYNGQKADLNLYKGADGTYQMYDYGFRDAATPFSGPLLQTWDARGVDVSAASGVWPSGAAIFKSGTPDLSADFTDSGAVDAHWAANKVYAYYKDHFGRKGLDDKDGFMYSLVGVTANGQPYNNAFWDGSKMVYGKGGGDFRTFSADTDVVGHEMTHGVTEHSAGLVYAGQSGAMNEAISDYFGNAIDLEANGQSMDDPDSGLLGEDLCTTQSPRECALRDLNDGHTTSKDFIGTTYRGDNGGVHLNSTIFSGALWDMRQDLGGDLADKIVYRALTAYMTPLDGFTEGRAAVIAAAQELGVTKAQLKKVKSSFDAHGIVPGWETALGVDTDTLIAKDNVAGTGVGAGGGKYAVSRSNEDGSEPYAVWVGNTSGKGQPQLVSPNNGNYNVYASTDGKNVAWAEYAYDAVKIHVRPVGGGVDKVVDGIGTDVTSVTIKGDVLAYGYVNPKTGLPQVRYVNIKTGATMEMSTNPVMATTLPSVHDGKIAYAKLWAESDGYKLGVEVYDTATGKRQLMPIDKSAVYGIGQTAFTDDGVFWVEDNDITDTGQAAVMRADADGTNRTTVTPESGAGSLYAYQLTASDDAVTVLTLPPATWWANETLPKLYQVAPDGKGGAQRVSCNRGDQVYPSADTGQRVLWLDGTTGYTNLVKRDRPAGKC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JR92</accession>
    <name>A0A2M9JR92_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_24030</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000009">
        <property type="protein sequence ID" value="PJN09395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN09395">
        <property type="protein sequence ID" value="PJN09395"/>
        <property type="gene ID" value="CG723_24030"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="79"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN09395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="136" mass="14793" checksum="E504D5E1556AE4DA" modified="2018-04-25" version="1">MARGSRRTAEQIADGIAQFCENIERTRATLARGPADGTRLLDELLDALRDGTDPSEQLEAVHHALRRGQDAIGVFGRTRDISMATPPGIPPARTDEPVLLCPRPDNPCTRYSWPTPGSTHVCHVTGTPLRRSTLAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JRJ2</accession>
    <name>A0A2M9JRJ2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CG723_22100</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000008">
        <property type="protein sequence ID" value="PJN09468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN09468">
        <property type="protein sequence ID" value="PJN09468"/>
        <property type="gene ID" value="CG723_22100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PJN09468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="135" mass="14237" checksum="85472532E3575498" modified="2018-04-25" version="1">MTACHPADIRQTAAEAALAVSGVLALQPTLASRLARAASRATAGAADSRFASPLSGIRVVHDPDGSGWQVEVRCVLAEGHRAIDVARAVHDRTRASLTPLVTMHGTADTVTVTVTITRITRTKPKVARRPLKSKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JRQ3</accession>
    <name>A0A2M9JRQ3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Glucarate dehydratase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CG723_22555</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CB01635</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the mandelate racemase/muconate lactonizing enzyme family. GlucD subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000008">
        <property type="protein sequence ID" value="PJN09528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN09528">
        <property type="protein sequence ID" value="PJN09528"/>
        <property type="gene ID" value="CG723_22555"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd03323">
        <property type="entry name" value="D-glucarate_dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036849">
        <property type="entry name" value="Enolase-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029017">
        <property type="entry name" value="Enolase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029065">
        <property type="entry name" value="Enolase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034598">
        <property type="entry name" value="GlucD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013342">
        <property type="entry name" value="Mandelate_racemase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034593">
        <property type="entry name" value="Mandelate_racemase_DgoD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013341">
        <property type="entry name" value="Mandelate_racemase_N_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48080">
        <property type="entry name" value="PTHR48080"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13378">
        <property type="entry name" value="MR_MLE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02746">
        <property type="entry name" value="MR_MLE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00922">
        <property type="entry name" value="MR_MLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51604">
        <property type="entry name" value="SSF51604"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54826">
        <property type="entry name" value="SSF54826"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MR_MLE" evidence="4">
        <location>
            <begin position="177"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="3">
        <location>
            <begin position="227"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="3">
        <location>
            <begin position="326"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="2">
        <location>
            <position position="199"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="2">
        <location>
            <position position="326"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="28"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="107"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="152"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="197"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="275"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="355"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="409"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009938"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR634598-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR634598-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PJN09528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="430" mass="46712" checksum="F8121CFE41202F61" modified="2018-04-25" version="1">MNDLTISDVRLTPILVADPPLLNAQGVHQPYTPRLIIEVTTADGITGLGETYGDTKYLELARPYAEKLVGRSVADLNGLFTLADEVAVAEERVTGQVDVGGLRGVQTADKLRLSVVCGFEVACLDALGKAQGLPVHALLGGKVRDTVEYSGYLFYKWGEHPKGVDSEVDDWGEAVDPAGIVDQARKFTERYGFRSFKLKGGVFAPEQEIAAIRALAEAFPGSPLRLDPNGAWSVETSVKVIEALQDVLEYMEDPTLGTPNMAAVAARTGVPLATNMCVTTFDEVKEAFTCDAVQVVLSDHHYWGGLRNTRELAAICRTFGVGVSMHSNTHLGISLAAMTHVASTVPNLHHACDSHYPWQSEDVLNERITFTDGKVTVSDAPGLGVTLDRDRLAVLHQRWLDDDGTMRERDDAAAMRVAAPAWETPAFPRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-05-25" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JS78</accession>
    <name>A0A2M9JS78_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_20750</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000007">
        <property type="protein sequence ID" value="PJN09647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN09647">
        <property type="protein sequence ID" value="PJN09647"/>
        <property type="gene ID" value="CG723_20750"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NADP_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="SSF51430"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldo_ket_red" evidence="1">
        <location>
            <begin position="16"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN09647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="332" mass="35978" checksum="1B9A0AA4B9B91E7E" modified="2018-04-25" version="1">MERRTIGAAALEVGAIGLGCMPMSWAYTGSRQRGDESVRTVHAALDRGSTLLDTADMYGPFTNELLLGRVLKERRGDAFVSTKCGLLVGEQHIVANGRPGYVKRACDASLRRLQTDTIDLYQLHRADPEVPVEETWGAMAELVGAGKVRALGLCAVGARATRRGRAGLHAGTIRQLERVQQVFPVSAVEAELSVWSPEALETLLPWCETRGVGFLAAMPLGNGFLTGTLTPGQGFEPDDLRARHPRFTAEMMAANQPIVAGLRRIAARHGEAVTPAQVALAWVLGRGRHVVPVPGAKRERWAAQNAEAAELKLTDRDLAEIRELPRARGSWD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JSS3</accession>
    <name>A0A2M9JSS3_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF4328 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_19505</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000006">
        <property type="protein sequence ID" value="PJN09925.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN09925">
        <property type="protein sequence ID" value="PJN09925"/>
        <property type="gene ID" value="CG723_19505"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025565">
        <property type="entry name" value="DUF4328"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14219">
        <property type="entry name" value="DUF4328"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="59"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="144"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="182"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4328" evidence="2">
        <location>
            <begin position="50"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN09925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="222" mass="24145" checksum="A46271C4D2C266F8" modified="2018-04-25" version="1">MLKSPVGVSKAVVVLLGVTGAIDLFALWVGFEQRSLAADFVAGRFSAGSDADADRIDSLYSAAGVAQLCAMVATAVVFIVWFRRVRINAEVFRPDGHSRSRGWASWGWFVPVVNLWAPRQVATDTWDASVPEAGLIPRKYSRKVINSWWSLWLVSNVIGRLAGSQYDKAESIGEIKTATEMLMLSDALDIAAAVAAIMFVRALTRMQNEKALRGPAMAPFPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JSS8</accession>
    <name>A0A2M9JSS8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Methylmalonyl-CoA mutase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CG723_19395</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CB01635</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>adenosylcob(III)alamin</name>
            <dbReference type="ChEBI" id="CHEBI:18408"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="2">Heterodimer of an alpha and a beta chain.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000006">
        <property type="protein sequence ID" value="PJN09908.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN09908">
        <property type="protein sequence ID" value="PJN09908"/>
        <property type="gene ID" value="CG723_19395"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031419">
        <property type="term" value="F:cobalamin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004494">
        <property type="term" value="F:methylmalonyl-CoA mutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016176">
        <property type="entry name" value="Cbl-dep_enz_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006099">
        <property type="entry name" value="MeMalonylCoA_mutase_a/b_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006098">
        <property type="entry name" value="MMCoA_mutase_a_cat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01642">
        <property type="entry name" value="MM_CoA_mutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51703">
        <property type="entry name" value="SSF51703"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00641">
        <property type="entry name" value="acid_CoA_mut_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="METMALONYL_COA_MUTASE" evidence="3">
        <location>
            <begin position="6"/>
            <end position="518"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PJN09908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="526" mass="57304" checksum="2B9BD82450ABD97A" modified="2018-04-25" version="1">MARESESGLPIEPVYGPDSLADWNAAEKLGEPGKYPFTRGVYPSMYTGRPWTMRQYAGFGTAVESNARYKQLIANGTMGLSVAFDLPTQMGHDSDAPIASGEVGKVGVAIDSIDDMRILFGGIPLDKVSTSMTINAPAALLLLMYQLVGEEQGVPADQLTGTIQNDVLKEYIARGTYIFPPKPSLRLIADIFKYCRAEIPKWNTISISGYHMAEAGASPAQEIAFTLADGIEYVRTAVAAGMDVDDFAPRLSFFFVARTTILEEVAKFRAARRIWAKVMKEEFGAKNPKSLMLRFHTQTAGVQLTAQQPEVNLVRVAVQGLGAVLGGTQSLHTNSFDEAIALPTDKSARLALRTQQVLAYETDVTATVDPFAGSYVVEKMTDDVEAAALELMTKVEDLGGAVNAIEHGFQKNEIERSAYRIAQETDSGERVVVGVNRYQLDAEEPYEPLRVDPAIEAQQAERLTKLRAERDQAAVDAALAALKKAAEGEDNVLYPMKDALRARATVGEVCNALRDVWGTYIPTDAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JSX8</accession>
    <name>A0A2M9JSX8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CG723_19935</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000006">
        <property type="protein sequence ID" value="PJN09996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN09996">
        <property type="protein sequence ID" value="PJN09996"/>
        <property type="gene ID" value="CG723_19935"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014747726" evidence="3">
        <location>
            <begin position="30"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="304"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="32"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="262"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="47"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="72"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="282"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PJN09996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="335" mass="33901" checksum="822916CBF5273F6D" modified="2018-04-25" version="1">MKLRRALAAAAATAAIAPIALLSAPAAFADGTPDTTTVTTETPSTPAETPPSTPATPSSPETTPSTPESPSTPASTPATTPASTPSGTPSDSTSPSPSATPTEEPTLPTGICEVDNEDYQSKLSVSISGLPGKIAAGSGWHGFTLNVKNPTKTDLDEAIFYAGVGPNDENAENAYKASQVRLQAKVDGSWVDIDDGDGYSFGFLDLSGIKAGKSVNYQLRLNVKAGAPIGEGLTIGGGFYNDDELDCLSDTSASYIIQIVKPGTDTDGTKPQEGGKVPMPTEKPNDNNTQEVTGSLAETGSSSMVPTIGLIGGVAVVAGAGAVFAVRRRKAGATA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JSY1</accession>
    <name>A0A2M9JSY1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Lipase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_19840</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000006">
        <property type="protein sequence ID" value="PJN09980.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN09980">
        <property type="protein sequence ID" value="PJN09980"/>
        <property type="gene ID" value="CG723_19840"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="91"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="92"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN09980.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="331" mass="35488" checksum="2C4DBCFB631FB7C8" modified="2018-04-25" version="1">MKVTSILPFRPLCQLIPTRLVFPARLAGVSVSLLKATALEVAILAGHLLLYPSGIIQERRAAPELPALGYTPAPKGLDEGADDASYLTESATLPGPEAQNAHSTPDSLSARLPVTESKPPVLLLHGFIDNRSVFLLLRRSLAQHGRHHVESLNYSPLTYDIRTAAALLARHVEEICERTGHDRVDVVGHSLGGLIARYYVQCLGGDLRVRTLVSLGTPHRGTTVAPLMNAHPIVRQMRPGSTVIEELSRPAPGCRTHFVSFWSDLDQIMVPLETACIDHPDLIAQNVRVTGVGHLALPVHPAVAAGIRQALDAEETEGARSADAVGGLTVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JT88</accession>
    <name>A0A2M9JT88_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">TetR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CG723_20390</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CB01635</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">TetR is the repressor of the tetracycline resistance element; its N-terminal region forms a helix-turn-helix structure and binds DNA. Binding of tetracycline to TetR reduces the repressor affinity for the tetracycline resistance gene (tetA) promoter operator sites.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000006">
        <property type="protein sequence ID" value="PJN10073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN10073">
        <property type="protein sequence ID" value="PJN10073"/>
        <property type="gene ID" value="CG723_20390"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046677">
        <property type="term" value="P:response to antibiotic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004111">
        <property type="entry name" value="Repressor_TetR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003012">
        <property type="entry name" value="Tet_transcr_reg_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02909">
        <property type="entry name" value="TetR_C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00400">
        <property type="entry name" value="TETREPRESSOR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0046">Antibiotic resistance</keyword>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="6">
        <location>
            <begin position="16"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="5">
        <location>
            <begin position="39"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PJN10073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="222" mass="24566" checksum="25716C2AA2AC40E0" modified="2018-04-25" version="1">MPQPSAPRKSPGRPPRISREEVIGAARRIVAEEGVDRLTMRRLATEIGSTPMALYHHVRNKEELLVLLLDDYAAQALRRPELPAHPRERIVVAAAAIHEALASCPWIVEVLTADDLMSTSALWFVEQIVDGLVEGGLSAERAVHGYRAIWYYTAGEIVIRATAARRRADDDRATYREQVFGDLDPGDLPRLAQVADRWAALTGEDTYLDGLRALVDGLLAAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-05-25" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JTM6</accession>
    <name>A0A2M9JTM6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DNA-binding response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CG723_19590</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000006">
        <property type="protein sequence ID" value="PJN10137.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN10137">
        <property type="protein sequence ID" value="PJN10137"/>
        <property type="gene ID" value="CG723_19590"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00383">
        <property type="entry name" value="trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="3">
        <location>
            <begin position="1"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="domain" description="OmpR/PhoB-type" evidence="4">
        <location>
            <begin position="125"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="2">
        <location>
            <begin position="125"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PJN10137.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="224" mass="24856" checksum="7C8F2FAF953D2345" modified="2018-04-25" version="1">MLIVEDEPSITDVLAIALRYHRFEVMTAGTVREGLALATRTRPDAALLDVMLPDGDGRALGRELRARRPDLALVFLTARDAPAEIVGALGFGDDYITKPFNIDEVVARLGAVLRRTRSADVLPERPPLRYGDLELDETAYTVHRSGHTVQLTPTEYALLRFLVRNGGRVVPKEQLLRHVWQYEHTAESTVVETYISYLRRKLEALGPPLITTRRGVGYGLAGGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JU28</accession>
    <name>A0A2M9JU28_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_18295</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000005">
        <property type="protein sequence ID" value="PJN10332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN10332">
        <property type="protein sequence ID" value="PJN10332"/>
        <property type="gene ID" value="CG723_18295"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011044">
        <property type="entry name" value="Quino_amine_DH_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011964">
        <property type="entry name" value="YVTN_b-propeller_repeat"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50969">
        <property type="entry name" value="SSF50969"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02276">
        <property type="entry name" value="beta_rpt_yvtn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015000082" evidence="2">
        <location>
            <begin position="28"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="25"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="25"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN10332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="370" mass="38241" checksum="9856BFC487DC65A0" modified="2018-04-25" version="1">MTARARGVLGAMAVVLLAAGCTATGTADSTASSPRAATVTPSAPAPARTAHGTLLVADFGSDTVTFVDPERGTLDAVKVGTAPYGLVVGKDGRAWVATAEGVAVVDTETRENVGRIPYTTETGPATTGEYRGGGMGIALAPDGKHVYVGVNVPDGNGVLEVVDTATRKVTDTVPVGRRPFDVDVARDGSEVYATGHDSFDVTAVRTDTLTPRRFEVAPYGTEGGLGSWLKPHYAAVRDDGKLLLPFEGEKLAVLDPRTGKVAVEPMTADTHQHGARLTPDGTLLAVGTGPISAGDNDASLTIRTAEGKERVVPLDGPHEDVAASRDGRTAYVTGGFTRDGFWDGITVVDLESGKTHRLPAGHRPLGIAVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JU39</accession>
    <name>A0A2M9JU39_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_18375</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000005">
        <property type="protein sequence ID" value="PJN10342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN10342">
        <property type="protein sequence ID" value="PJN10342"/>
        <property type="gene ID" value="CG723_18375"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN10342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="102" mass="10503" checksum="B8ADFAC346492417" modified="2018-04-25" version="1">MDAYARNLRATGREVPEPGPSPVGTGGSTDRGNLTHALPAIHPAIGVLGAQDMPRTPQFAEEVSGSAGDEAVLDGALAMVRTGLDLAIAPERRTRCVASRQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JU67</accession>
    <name>A0A2M9JU67_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">PBPb domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CG723_18915</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000005">
        <property type="protein sequence ID" value="PJN10431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN10431">
        <property type="protein sequence ID" value="PJN10431"/>
        <property type="gene ID" value="CG723_18915"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001638">
        <property type="entry name" value="Solute-binding_3/MltF_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00497">
        <property type="entry name" value="SBP_bac_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00062">
        <property type="entry name" value="PBPb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014637727" description="PBPb domain-containing protein" evidence="2">
        <location>
            <begin position="30"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="domain" description="PBPb" evidence="3">
        <location>
            <begin position="65"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PJN10431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="315" mass="32836" checksum="071DBAAF1A20D49A" modified="2018-04-25" version="1">MYISVPRRGATAVLACTALAVISGCGAGGADGARPASRDKVAGVTVTRDAALHEALPERIRKAGTVRVATDVPYPPFAMFVTEGKSELTGLDYDLGQALGAKLGVRFAFTPTKFDGIVPALQAGKFDAAMSALTDNKERQKVVDFVDYSRSGSGILVTEGNPAKISTLDDLCGRKVGVQAATNQYKLLEAHQADCRAAGRKAADIQTFPKDSDAQLALRSGKVTAEVVTKPAAGWSAKTADGGKAFDLAEDPKAPAGYRASPNGIAVTRQLPQLTDAIRRALQALIDDGTLTKICDKYGVASIAVKEATKNAAVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JUI4</accession>
    <name>A0A2M9JUI4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">D-alanyl-D-alanine carboxypeptidase/D-alanyl-D-alanine-endopeptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">dacB</name>
        <name evidence="3" type="ORF">CG723_14990</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S13 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000004">
        <property type="protein sequence ID" value="PJN10529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN10529">
        <property type="protein sequence ID" value="PJN10529"/>
        <property type="gene ID" value="CG723_14990"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004185">
        <property type="term" value="F:serine-type carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000667">
        <property type="entry name" value="Peptidase_S13"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30023">
        <property type="entry name" value="PTHR30023"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02113">
        <property type="entry name" value="Peptidase_S13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00922">
        <property type="entry name" value="DADACBPTASE3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00666">
        <property type="entry name" value="PBP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="21"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN10529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="539" mass="56523" checksum="0D7B457ACCC40E48" modified="2018-04-25" version="1">MSRPDGPVRRLLNPLARQRRYLVWPALVALAAGLTWGSPAGADGDSTGLPEAIDTILGDPSMEGGAASVVVADARSGDIIYQHNPTGRLMPASNTKLLTSTAATELLGTGYRFTTDVLGDGRRRGSVLDGDLYLRGTGDPTALAKDYDELAAKVAASGVRSVSGRLVADDTAFDGQRLGRSWAADDESSYYSAQISALSVAPDTDYDTGTVIVEAAPGAKAGDKPKITVTPKTHYVDIDVRATTVAAGGDDSLTVERQHGTNTVTVSGTVPVDGGTTKEWVTVWEPTGYAASVFRDALAAHGVRVSGGTKLGRATPKGAVRLATHDSMPLKDLLIPFMKLSNNMHAEILTKAMGAKATGRAGTWDDGLAAISGYLKGVGVDTGRLRQVDGSGLSRMDSIPAGQIARLLLAVRAEPWFGDWYKALPVACDPDRFVGGTLRSRMCRTPAALNARGKTGSLTGASALSGYVKDAGGRELVYSIVQNNYLVDSVKPLEDAIVVTLAKSDADAAVAVRPRSLRSVPVSERKGDLECSWRKPAVC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JUM6</accession>
    <name>A0A2M9JUM6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Esterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_14985</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000004">
        <property type="protein sequence ID" value="PJN10528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN10528">
        <property type="protein sequence ID" value="PJN10528"/>
        <property type="gene ID" value="CG723_14985"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010126">
        <property type="entry name" value="Esterase_phb"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10503">
        <property type="entry name" value="Esterase_PHB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01840">
        <property type="entry name" value="esterase_phb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015006593" evidence="2">
        <location>
            <begin position="22"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN10528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="316" mass="32648" checksum="17EE223DD50D1BB8" modified="2018-04-25" version="1">MFVALIAALLSVFLPAPRADAAAAIQEVAGFGTNPGALKMYRYVPDGLPAGRPVVVALHGCTQNASGYGTGSGWTELADRWGFSVVLPQQQSGNNASSCFNWFQAGDIERGQGEAASVAQMVDRQLADASGDPAKVYVTGLSAGGGMTSVMMAAYPEKFAAGGVVAGLPYGCAAAAGSPYVCMYVGATQTAQQWGDRVRAARPGYAGPWPRLTVFQGSADYTVKPVNMTDLMKQWTDVQGADQVADVSDSVAGYPHQVFRRADGSAAVETYSMTGMGHGQPVDPGSGAAQCGTAGAYILDVNLCAAYEMGRSWGLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JUM8</accession>
    <name>A0A2M9JUM8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_15395</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000004">
        <property type="protein sequence ID" value="PJN10601.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN10601">
        <property type="protein sequence ID" value="PJN10601"/>
        <property type="gene ID" value="CG723_15395"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014760772" evidence="1">
        <location>
            <begin position="28"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN10601.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="132" mass="13565" checksum="A2AA903003956B1C" modified="2018-04-25" version="1">MAARPRHRRRIAVLAATAALIALPAAAGCGALDKALDCVQTADSIADSVSDLKQAVESATNDPAQADKALDSIDRNLDKIGDKTDNADVSKAVDDLNTAVGNVRTAIKNGDETPDITPVTDAAGELTKVCTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JUR6</accession>
    <name>A0A2M9JUR6_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">NHase_beta domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_15270</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000004">
        <property type="protein sequence ID" value="PJN10578.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN10578">
        <property type="protein sequence ID" value="PJN10578"/>
        <property type="gene ID" value="CG723_15270"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018822">
        <property type="term" value="F:nitrile hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024690">
        <property type="entry name" value="CN_hydtase_beta_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008990">
        <property type="entry name" value="Elect_transpt_acc-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02211">
        <property type="entry name" value="NHase_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50090">
        <property type="entry name" value="SSF50090"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NHase_beta" evidence="2">
        <location>
            <begin position="3"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN10578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="91" mass="10300" checksum="8F5D932352A97C9B" modified="2018-04-25" version="1">MTDRFAAGAHVRTYPHDPPHHTRLPRYARGKRGVVVEPEGRAPLADVRAQGRDDAPVEMIYAVRFAARELWGEGDHHVVLDLSESYLREAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JVC3</accession>
    <name>A0A2M9JVC3_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Peptidoglycan glycosyltransferase</fullName>
            <ecNumber evidence="2">2.4.1.129</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CG723_16830</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CB01635</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>[GlcNAc-(1-&gt;4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)](n)-di-trans,octa-cis-undecaprenyl diphosphate + beta-D-GlcNAc-(1-&gt;4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate = [GlcNAc-(1-&gt;4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)](n+1)-di-trans-octa-cis-undecaprenyl diphosphate + di-trans,octa-cis-undecaprenyl diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23708"/>
            <dbReference type="Rhea" id="RHEA-COMP:9602"/>
            <dbReference type="Rhea" id="RHEA-COMP:9603"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58405"/>
            <dbReference type="ChEBI" id="CHEBI:60033"/>
            <dbReference type="ChEBI" id="CHEBI:78435"/>
            <dbReference type="EC" id="2.4.1.129"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.129" evidence="2"/>
    <dbReference type="EMBL" id="NNBL01000004">
        <property type="protein sequence ID" value="PJN10836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN10836">
        <property type="protein sequence ID" value="PJN10836"/>
        <property type="gene ID" value="CG723_16830"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018365">
        <property type="entry name" value="Cell_cycle_FtsW-rel_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001182">
        <property type="entry name" value="FtsW/RodA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011923">
        <property type="entry name" value="RodA/MrdB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30474">
        <property type="entry name" value="PTHR30474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30474:SF1">
        <property type="entry name" value="PTHR30474:SF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01098">
        <property type="entry name" value="FTSW_RODA_SPOVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02210">
        <property type="entry name" value="rodA_shape"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00428">
        <property type="entry name" value="FTSW_RODA_SPOVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0133">Cell shape</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="34"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="67"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="101"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="140"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="177"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="213"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="303"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="332"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="370"/>
            <end position="387"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PJN10836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="398" mass="42366" checksum="716B5E5322826EFA" modified="2018-04-25" version="1">MAGTNGFSVSGYGPERSTLARLMARDSVLRRLDWPILLSSLALSLIGSALVYSATRNRTVINQGDPYFFLFRHLMNTGIGLALMIGTIWLGHRTLRTAVPILYGASVFLMLLVLTPLGDTINGQRNWLSAGGVSLQPAEFAKITIILGMAMLLASRVDAGDKQYPDHRTVVQALGLAAVPMLVVLLMPDLGTIMVAAIIVLGVLLASGASNRWVFGLLGAGVLGAISVWRLHILDEYQINRFAAFANPALDPAGVGYNTNQARIAIGSGGLTGTGLFHGSQTTGQFVPEQQTDFVFTVAGEELGFAGAGLILLLLGVILWRACRIARETTELYGTIVAAGIIAWFAFQTFENVGMTLGIMPVAGLPLPFVSYGGSSMFAVWVAIGLLQSIRVQRPMSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JVK8</accession>
    <name>A0A2M9JVK8_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">SSD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CG723_17205</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CB01635</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000004">
        <property type="protein sequence ID" value="PJN10900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN10900">
        <property type="protein sequence ID" value="PJN10900"/>
        <property type="gene ID" value="CG723_17205"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004869">
        <property type="entry name" value="MMPL_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000731">
        <property type="entry name" value="SSD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03176">
        <property type="entry name" value="MMPL"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50156">
        <property type="entry name" value="SSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="174"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="198"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="230"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="270"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="307"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="364"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="507"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="531"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="564"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="605"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="638"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="domain" description="SSD" evidence="7">
        <location>
            <begin position="209"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PJN10900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="696" mass="72371" checksum="5D2828181A8D2A84" modified="2018-04-25" version="1">MGGVPTKRRRAAVPWTLLGLWIVVLAIAGPFAGKLSDVQHDRAVDYLPASADSTQVAKIQDELPGGESTELVLVYHRDGGLTAADRTTAAAQVARIDRGFDLTAVPKGVPSRDGATLMYPVASTTPGHDEKARDAFVNDVRDIAHDTDGLSVDTGGAGALATDASEVYGSLDGPLLYTTVAVVAILLILIYRSPFLWLVPLVVAGVADFLSMGVAYGLHQAVGTTVSGQSSGVMTILVFGAGTDYALLLVSRYREELRRIERPHDAMRAALRGCGPAVLASSGTVAVGLFCLLAADLNSSRGMGPLGAVGVLCALAAMLTLLPAVLVLLGRRVFWPLVPAYGSTPKARRSLFAAMGSSAGRRPLTVLASGALLLGALALGVFSLPGSLKQEDTFTDKPDSVVAMQTLAAAYPERGSQPISVITPTGRAGETLATARDVPGVAAAEQVRSGHGWTEISVTASSPPQSTGETTTIETLRDRLDGKGSYVGGQSAQQLDLRDTNSRDRKVVVPIVLAAVLLILVVLLRSLVAPLILLAAVVAVWGASLGIAGLVFGPLFDFQGTDPGLGLLTFVFLVALGVDYGIFLMHRMREESLAGAEPGAAALTALRTTGGVIASAGLVLAATFSVLTNMPLVSLVEMGFVIAVGVLLDTFLVRTYLVTSASMALGRAVWWPGPLSRKPQTLPPAQEPERTLAPTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JVR9</accession>
    <name>A0A2M9JVR9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_15980</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000004">
        <property type="protein sequence ID" value="PJN10932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN10932">
        <property type="protein sequence ID" value="PJN10932"/>
        <property type="gene ID" value="CG723_15980"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="51"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN10932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="84" mass="8750" checksum="CD661F90FCE8CEA1" modified="2018-04-25" version="1">MSDVVRWAAFSCVLVPVVLVGYGFSLAGAMGAALGLAAVTGVCRVLLRQSERSAARPAPVRSCDHRGRRGRTVPGARKGGRRTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JW85</accession>
    <name>A0A2M9JW85_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">D-beta-D-heptose 1-phosphate adenosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CG723_08970</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN11092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN11092">
        <property type="protein sequence ID" value="PJN11092"/>
        <property type="gene ID" value="CG723_08970"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014036">
        <property type="entry name" value="DeoR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001034">
        <property type="entry name" value="DeoR_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00455">
        <property type="entry name" value="DeoRC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08220">
        <property type="entry name" value="HTH_DeoR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00037">
        <property type="entry name" value="HTHLACR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00420">
        <property type="entry name" value="HTH_DEOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="SSF100950"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51000">
        <property type="entry name" value="HTH_DEOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="HTH deoR-type" evidence="3">
        <location>
            <begin position="3"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PJN11092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="253" mass="26899" checksum="BA9A527343D3A6D7" modified="2018-04-25" version="1">MYAPERQQEILRLARDGGRVDVLSLAEEFQVTAETIRRDLKTLDRAGLVRRVHGGAIPAGRLDFEPDVAEREGTAADEKDRIARLALAELPEDGTVILDAGTTVARLAAALPLESTLTVVTHGLPVAARLADHPGIQLHLVGGRVRHRTRAAVDAWALRAYGEIRADVLFLAANGFSAEHGLTTPDLAEAAVKRAAVSAARRVVLLADAAKYGQEHFARFGDLGDVDVLITDSGLSDADAAAIEKGGTEVVRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JWE4</accession>
    <name>A0A2M9JWE4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MarR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_09740</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN11215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN11215">
        <property type="protein sequence ID" value="PJN11215"/>
        <property type="gene ID" value="CG723_09740"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000835">
        <property type="entry name" value="HTH_MarR-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023187">
        <property type="entry name" value="Tscrpt_reg_MarR-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12802">
        <property type="entry name" value="MarR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00598">
        <property type="entry name" value="HTHMARR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00347">
        <property type="entry name" value="HTH_MARR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01117">
        <property type="entry name" value="HTH_MARR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50995">
        <property type="entry name" value="HTH_MARR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH marR-type" evidence="1">
        <location>
            <begin position="37"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN11215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="180" mass="19875" checksum="E77B1332ED4D1C50" modified="2018-04-25" version="1">MLPEQPHGPHRPGRPLDHIARIQAEWARERPDVDVTPQGVIGRLHRLGALLTEQLCLVYRRYGLSEGEFDVLAALRRAGEPFERAPGELAAHTMVTTGAMTKRIDRLERGGLVTRRRAAGDGRGRVVALTPAGRDLIDDAFSEHMANEHRLLAALGPDEAEHLESLLTSWLARVEPPRGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JWH8</accession>
    <name>A0A2M9JWH8_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">SBP_bac_5 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CG723_09785</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN11224.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN11224">
        <property type="protein sequence ID" value="PJN11224"/>
        <property type="gene ID" value="CG723_09785"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042597">
        <property type="term" value="C:periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030678">
        <property type="entry name" value="Peptide/Ni-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039424">
        <property type="entry name" value="SBP_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000914">
        <property type="entry name" value="SBP_5_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30290">
        <property type="entry name" value="PTHR30290"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00496">
        <property type="entry name" value="SBP_bac_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002741">
        <property type="entry name" value="MppA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014721796" description="SBP_bac_5 domain-containing protein" evidence="2">
        <location>
            <begin position="51"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="domain" description="SBP_bac_5" evidence="3">
        <location>
            <begin position="97"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="188"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PJN11224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="562" mass="61466" checksum="93AECC1FF83BA869" modified="2018-04-25" version="1">MNPMKRTNATTPTTRFRTHGIRTGTLGALALALAATGCSATPTASGGAGASSLTANLGFSGTTITRNFNPFSLTASQGTFGFQYEALFDFNILKGGEFKPWLGTKYTWSDGGKKITIDLDKRANWSDGSQLTAADVVFTMDYVRDNKLPPSWAFDYKKATAADDHTLEITFDKPAYSKLDSIGGITPVPKKEWQGRNGKTYTNPNPVGSGPYKLGQYSAQQLTFQARANYWKQKDIPVKTVKAPVITQAAEVPKLLSGELEWSGGVVPDVQKQYISKDPKNHHAWYPTYGGQYMFFNHKKKPFTDVHVRRALSLAVDRTQLLGITNPGMFNTLNLTGLDSRTQGKWIDAKYKDAEQPKAELAKSLAEFEKAGYTRKNGKLVDGSGKQLAFTIIEVSTWGDAVQFDKVVASQLEKAGVNVSVKPTDASQLDVKRKKGDFDVLIGGAVYYSTPYNYFKDMLWSGNAGVWTNYGHYKSTKADALIKELGETGDQAEIKKISAELEGMMVDDVPAAPLITIGVSSEYNSRNWTGWPTAKNPYAQPAPWAGGIDSMSILLNLRPAKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JWQ1</accession>
    <name>A0A2M9JWQ1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CG723_09520</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN11177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN11177">
        <property type="protein sequence ID" value="PJN11177"/>
        <property type="gene ID" value="CG723_09520"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="2"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="34"/>
            <end position="41"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PJN11177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="231" mass="24527" checksum="5E00FA2B598D9D3B" modified="2018-04-25" version="1">MLELDNISAGYGGTRVLRDVCLWLPPKSVVALLGTNGAGKTTLLRVASGLLTPSSGRLSVDGKDLTGKRPHTLARNGVCHVPEGRGVFPTLTVKENILIQAAGGDLDEAVERAVSAFPALSQKLGQLAGSLSGGQQQMLALAHAYVADADYVLLDEVSMGLAPVVVDEIFEFLGRLADDGRALLLVEQYVARALELADYVYLMNRGRIEFAGEPGELDSDRLIAQYLGAHT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JXA8</accession>
    <name>A0A2M9JXA8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Nucleotidyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_11530</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN11525.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN11525">
        <property type="protein sequence ID" value="PJN11525"/>
        <property type="gene ID" value="CG723_11530"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002934">
        <property type="entry name" value="Polymerase_NTP_transf_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01909">
        <property type="entry name" value="NTP_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="SSF81301"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="NTP_transf_2" evidence="1">
        <location>
            <begin position="15"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN11525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="262" mass="29028" checksum="6BDAE9E511DD81F6" modified="2018-04-25" version="1">MTTAEAHPAATTDLLDRFLTGLRETLPAPFSLWAHGSLAGGDYQEGRSDLDLIAVVPHPLKPDEETRLATLHEGIDAELPLAAHLHCSYMPQGDLDDPDRTHFTWAHREAYARTVTPITRRELHTYGLVLRGDPIAGTLPPVEDRTLREYILTDLTGYWRPRTGRPELWLENVWVDLGLMVLARATVTLRDGTLVSKAEALAVLTELGAPAEVVADIERRRYEGGPADTAPDPGWLARRAELTLDWLVPALDRTVAEHTTDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-09-29" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JXC3</accession>
    <name>A0A2M9JXC3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CG723_11520</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CB01635</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN11523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN11523">
        <property type="protein sequence ID" value="PJN11523"/>
        <property type="gene ID" value="CG723_11520"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="47"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="78"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="103"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="135"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="165"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="196"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="221"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="265"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="296"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="335"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="359"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="400"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="435"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="7">
        <location>
            <begin position="12"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="461"/>
            <end position="481"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PJN11523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="481" mass="48772" checksum="725A48D07E03B340" modified="2018-04-25" version="1">MAPLPGLRGRLTIPVLAFGGILMAVMQTVVVPLLPDLPRLTGASPGAVSWTVTATLLAGAVLTPVLGRAGDMYGKRRVLLLALGLMTGGSVLCALTSDIRVLIAARALQGAAAAVVPLSISILRDELPPHRTGSAVALMSSTVGIGAALGLPLAALIVQYANWHVMFWATSALGALGLALACWAVRESPVREPGRFDTLGAAGLAGGLVCLLLAVSQGGQWGWGSARVVGLFAGAVVILALWSWQQLRADRPLVDLRLAVGRRVGLPHLAALLAGFAFYANSLVTAQLVQAPRSSGYGLGLSIVQTGLCLLPNGVIMLLLSPVSARVSAARGPRVSLAIGGAAMALGYVVRIADSRDLWVIVLGAAIVSTGTTFAYSALPTLILRAVPAGQTASANGVNVLMRTIGQAVSSAAVAAILVHHATGAGFPALRGYQMAFLMAGAVALVVIAAAFTVPADAADNGGRKSVSGTTGRTDKALEGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JYB6</accession>
    <name>A0A2M9JYB6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">TetR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_13610</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN11862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN11862">
        <property type="protein sequence ID" value="PJN11862"/>
        <property type="gene ID" value="CG723_13610"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041347">
        <property type="entry name" value="MftR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17754">
        <property type="entry name" value="TetR_C_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="6"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="29"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN11862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="188" mass="20610" checksum="18EE4EED7BFB49FD" modified="2018-04-25" version="1">MGRWEPNARGRLANAALELYSERGFEQTTVAEIAKRAGLTERTFFRHYADKREVLFAGSSQLEEALVKAVADVAKSAAPIDAVAVGLDTVSEFFADRRDFARQRQAVIMATAELQERELIKLASMSAALADTLRRRGVAEPAASLTAEAGVAVFKVGFERWIGAVEEREMSQCMRESLDALRTALTGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JYS8</accession>
    <name>A0A2M9JYS8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">RNA polymerase subunit sigma-24</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CG723_14465</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CB01635</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2">Interacts transiently with the RNA polymerase catalytic core formed by RpoA, RpoB, RpoC and RpoZ (2 alpha, 1 beta, 1 beta' and 1 omega subunit) to form the RNA polymerase holoenzyme that can initiate transcription.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN12008.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN12008">
        <property type="protein sequence ID" value="PJN12008"/>
        <property type="gene ID" value="CG723_14465"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050896">
        <property type="term" value="P:response to stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013249">
        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08281">
        <property type="entry name" value="Sigma70_r4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="SSF54427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="7">
        <location>
            <begin position="15"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4_2" evidence="8">
        <location>
            <begin position="125"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="94"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF08281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PJN12008.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="305" mass="32882" checksum="B7C2248924C498F8" modified="2018-04-25" version="1">MGTVGTSTDEVAGERRQLINVAYRLLGSVTEAEDAVQDAYARWYGLTRSRQEEILSPGAWLTTVTGRICLDLLGSARARRERYVGAWLPEPLPDRTEWDRGGGADPTGPEDPADQIVLDESVAMAFLVVLESMTPAERVAFVLHDVFRYPFAEIAGVLGRTPAACKQLAASARRRVSVARAPVTVTGQADVVRHVKEAWETKDIAALVGLLNPAAVMTADGGGMVGTVLRPVEGGARIAQYMVAIADKAPGLELLQRSVNGVPGLVAQRAGVVMTVASFDVSDGRVTRIWVVRNPEKLRPWARED</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JZ31</accession>
    <name>A0A2M9JZ31_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">GNAT family N-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_09990</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN12129.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN12129">
        <property type="protein sequence ID" value="PJN12129"/>
        <property type="gene ID" value="CG723_09990"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041496">
        <property type="entry name" value="YitH_GNAT"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18014">
        <property type="entry name" value="Acetyltransf_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="2">
        <location>
            <begin position="24"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN12129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="306" mass="32396" checksum="0C62314399AAA9CD" modified="2018-04-25" version="1">MTRPDPHTSGNHRTAGTPEVPERLDITRATLDDWSVISGWAAEEGWNPGLADARSFFAQDPDGFFIGRVDGEPVSAISVVNYGDDYAFLGFYLVRPDLRGRGYGIATWKAALTHAGGRTVGLDGVPAQQDNYRKSGFEPAHTTVRYAGVPQAPRSAEGDRAPGTVIPVADAGGLKSIALYDGACYPADRPRFLASWLAGDGHRALARVVDGRVTGYGVIRPALDTFRVGPLFADTPQDARALFDALIAAVGGAPVAVDVPESNPAAVALAEAYGLIPGFATARMYTGPVRPFAQERIFGITTLELG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JZ70</accession>
    <name>A0A2M9JZ70_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">F420-dependent methylene-tetrahydromethanopterin reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_12100</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN12175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN12175">
        <property type="protein sequence ID" value="PJN12175"/>
        <property type="gene ID" value="CG723_12100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011251">
        <property type="entry name" value="Luciferase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036661">
        <property type="entry name" value="Luciferase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00296">
        <property type="entry name" value="Bac_luciferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51679">
        <property type="entry name" value="SSF51679"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bac_luciferase" evidence="1">
        <location>
            <begin position="4"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN12175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="352" mass="38018" checksum="05140DC1E36E5D65" modified="2018-04-25" version="1">MRTSTTIEASGGSWRETVDFVTEAERLGMDICWVAEAWGSEAPSPLGYLAARTERMLLGSGIIQLATRTPAAIARAAITLSNISEGRFLLGLGPSGPQVIEGLHGVPFARPLSRMRETVEIVRQAVAGEKLSYEGREFTLPLPGGEAKPMRLSMRAEHDLPVYLATLSPKMLRLTGEVADGWLGTSFVPEGAQEAYFDHLDAGLAAAGRKRSDLDICQGAEVAFADDEDALRAMVAGRKKELAFSLGGMGSATTNYYNNAYSRQGWADTAAEVRARWQAGDRDGAAELITDDMVLATTLIGTEPMVRERLRVWSAAGVDTVRLYPAGDTLDARLTTLGRALDLVRDVGREER</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JZ80</accession>
    <name>A0A2M9JZ80_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Glycine/betaine ABC transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CG723_12480</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN12185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN12185">
        <property type="protein sequence ID" value="PJN12185"/>
        <property type="gene ID" value="CG723_12480"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="SSF54631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="7"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="41"/>
            <end position="48"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PJN12185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="317" mass="34336" checksum="D0155418C05420C8" modified="2018-04-25" version="1">MQSAADIVFDAATKTYAGSAEPAVDALSLTVPAGEICVLLGASGCGKTTALTLVNRLTELTSGDIRIDGRSIRDQDVIELRRSIGYVIQQAGLFPHMTIEENIATVPQVLGWKRSRTADRVRDLLELVGLPHKEYADRYPAQLSGGQRQRVGIARALAADPPIMLMDEPFGALDPVTREHMQDEFLRLHEQVRKTTLFVSHDIDEAVRMGDRVAILAKGGRLLQYDSPERILREPADDYVARFVGTDRGLKALTLRSLGELKLDPATGDDEASLRTGDTLRTALSALLAGGAERLPVADESGKTVGSVTVDLIREAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JZ96</accession>
    <name>A0A2M9JZ96_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CG723_14885</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN12077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN12077">
        <property type="protein sequence ID" value="PJN12077"/>
        <property type="gene ID" value="CG723_14885"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PJN12077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="64" mass="7132" checksum="EB1044042D95C291" modified="2018-04-25" version="1">MTSDVTSLIPDQDAAARRLETLTFEEAQDLLRLLQLIAGEGLDELSQEAEWFAREIAARIPSES</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-09-29" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JZB3</accession>
    <name>A0A2M9JZB3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CG723_13535</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CB01635</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN12211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN12211">
        <property type="protein sequence ID" value="PJN12211"/>
        <property type="gene ID" value="CG723_13535"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="61"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="89"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="114"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="148"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="175"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="209"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="239"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="278"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="308"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="343"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="373"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="416"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="448"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="23"/>
            <end position="474"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PJN12211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="502" mass="51546" checksum="71CA13F3765CCB21" modified="2018-04-25" version="1">MPAPPPSPSTQQEQLPDPRRWWALCVLGLAQLMILLDSTIVNVALPSMQTELGMADGDRPWVVTSYTVAFGGLLLLAGRIADHAGRKRVFASGLLGFAVASAAAGAAPTAQALFAARAVQGAFAALLAASALALVATTFADLRERRKAIAVFGALGGAGASLGVVLGGLLTQWFGWRWCLLVNVPIALAALLGTLWTPRDRARRLTGRIDLAGAVLGCGGLTTVVYGCSQAEAQGWTSPGVVGVLLAGAVLLTAFAWWQTRAAAPLLPPRLLRDRRRVASLLAGGALMAGQLSVSLYLTYYLQTVLDWSALASGLGFLPISLVTTATATQLGTRLLPRLGPRVMMTAGLCIAACGLFQLTLLDPDSTYAANVLPALITFSIGQGGSFLAIMTGATSDVPAQDSGIASATVNSAQQMGGSIGSAVFNTVAASAAAAFHGSRRAAALHGFTSAIWIPLALLLLAAVATATLAGHQSTRVYAHANTLRRNPEGVVKGQGSGNHGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JZH4</accession>
    <name>A0A2M9JZH4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CG723_04285</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000002">
        <property type="protein sequence ID" value="PJN12282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN12282">
        <property type="protein sequence ID" value="PJN12282"/>
        <property type="gene ID" value="CG723_04285"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PJN12282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="73" mass="7882" checksum="8C188DF3FB901457" modified="2018-04-25" version="1">MQLNEAGTADGDGDLVVRQDDLGAAVGDHMDAGHDLAPVTRKPAPIRRPHSILACRRALFTRRPWPCGPSPTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-05-25" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JZK0</accession>
    <name>A0A2M9JZK0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">NADP-dependent oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_04455</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000002">
        <property type="protein sequence ID" value="PJN12312.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN12312">
        <property type="protein sequence ID" value="PJN12312"/>
        <property type="gene ID" value="CG723_04455"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016628">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041694">
        <property type="entry name" value="ADH_N_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045010">
        <property type="entry name" value="MDR_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="PKS_ER"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43205">
        <property type="entry name" value="PTHR43205"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16884">
        <property type="entry name" value="ADH_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PKS_ER" evidence="2">
        <location>
            <begin position="26"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN12312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="343" mass="36741" checksum="858A6959CED9BC7F" modified="2018-04-25" version="1">MSVDTPQIPATSREWQLTSRPVGWPKPEDFQLSEVEIAQPGPGQVLVKNLYVSVDPYMRGRMSAAKSYVAPYELGKAMQGGAVGVVVASNDEGVAVGDHVLHFNGWREYATFDAKQAVKVDPEAAPLSTYLGVLGMTGLTAYAGLLRTLSFKEGDTVFVSGAAGAVGSQVGQIARLLGAGRVVGSAGSAEKVKLLVEEYGFDAAFNYKDGSVFEQLKEAAPDGIDVYFDNVGGDHLEAAIGRLNRDGRIAICGAISVYNDTEAAPGPRNLSRLIQTRGRIEGFLVGDHYDLQPQFVQQVGAWIRSGELKYRETVVEGIENNLEAFLGVLRGDNIGKMIVKLGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JZM0</accession>
    <name>A0A2M9JZM0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">SAM-dependent methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_13430</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN12207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN12207">
        <property type="protein sequence ID" value="PJN12207"/>
        <property type="gene ID" value="CG723_13430"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransf_11" evidence="1">
        <location>
            <begin position="101"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN12207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="291" mass="32455" checksum="FEFCDE1898D729B4" modified="2018-04-25" version="1">MTTAPHFTSAVPLPAQSTYQSRVAEYWNAEENPVNLELGKIDDLYHHHYGIGPADNSVLDEPDPTRRNDRITAELHRLEHAQANCLADHLGPLTATDRAFDAGCGRGGGSVVAHLRYGCQTDGVTISAKQADFANAQAAKRGIDGQVRYHHRNMLDTGLPTGAFGASWNNESTMYVELELLFAEHARLLRRGGRYVVITGCYNDGYGRASREVSLINAHYICDIHPRSEYFRAMARNRLVPVHVEDLTEAALPYWELRKQADHLVTGIEDTFLTAYKNGSFQYLMIVADRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-05-25" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JZY1</accession>
    <name>A0A2M9JZY1_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Enoyl-CoA hydratase 2</fullName>
            <ecNumber evidence="1">4.2.1.119</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Enoyl-CoA hydratase 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CG723_05120</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CB01635</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>a (3R)-3-hydroxyacyl-CoA = a (2E)-enoyl-CoA + H2O</text>
            <dbReference type="Rhea" id="RHEA:26526"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:57319"/>
            <dbReference type="ChEBI" id="CHEBI:58856"/>
            <dbReference type="EC" id="4.2.1.119"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.119" evidence="1"/>
    <dbReference type="EMBL" id="NNBL01000002">
        <property type="protein sequence ID" value="PJN12426.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN12426">
        <property type="protein sequence ID" value="PJN12426"/>
        <property type="gene ID" value="CG723_05120"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039569">
        <property type="entry name" value="MaoC-like_dehydrat_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002539">
        <property type="entry name" value="MaoC-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13452">
        <property type="entry name" value="MaoC_dehydrat_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01575">
        <property type="entry name" value="MaoC_dehydratas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="SSF54637"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="2" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MaoC_dehydrat_N" evidence="7">
        <location>
            <begin position="51"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="domain" description="MaoC-like" evidence="6">
        <location>
            <begin position="162"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="151"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00029334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00030115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF13452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PJN12426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="284" mass="30370" checksum="1043D81D0ACF887B" modified="2018-04-25" version="1">MPIDAAKAVAAEPRSAEITWDHKDIQLYHLGLGAGTPATDPDELRYTLESRLHVLPSFATVAGAGMGVVGGLAAPGIEVNLAHVLHGGQSVELHRPIPVKGSATSTSRVAAVYDKGKAAILVLRTEVADADGPLWTSDAQIFVRGEGGFGGDRGPSARVEAPTGEPDRTVDRPVREDQALLYRLSGDWNPLHADPEFAKLAGFDRPILHGLCSYGMTLKAVVDTLLDGDVSRVRSYATRFTGVVFPGETLRIRMWRSEGRIQVTVTAVERDEAPVLADTIVEHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K017</accession>
    <name>A0A2M9K017_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CG723_05400</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CB01635</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000002">
        <property type="protein sequence ID" value="PJN12475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN12475">
        <property type="protein sequence ID" value="PJN12475"/>
        <property type="gene ID" value="CG723_05400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="25"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="86"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="123"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="153"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="195"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="270"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="87"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PJN12475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="302" mass="32363" checksum="2AD404AE2616B5A0" modified="2018-04-25" version="1">MTTTTHPKTPTRPAWKENPRPATQAAKAVAISVVLALVLIPFLVIISTSLASNKEVVANGGWVLWPTDPTLRAYRNILSGGIVTKALGVSIGVTLTGTLASLACTSFLAYALSRPGVLGGKPVLLVILFTFLFPPGMIPAFLLVKGLGLQNMYAALIAPVLINVFNLVVLRGFFQGIPEELYEAARLDGAGDWTVFWRIVLPLSKAALAVVGLFYAVSYWNAWFNASIYLESDHWPLSQVLRTYVIGGAQISDTGLSEAGMVSAPQTTQMAVLVIATVPILLVYPFLQKYFTKGVLTGAVKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K079</accession>
    <name>A0A2M9K079_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 8">Pyruvate dehydrogenase E1 component</fullName>
            <ecNumber evidence="2 8">1.2.4.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">aceE</name>
        <name evidence="13" type="ORF">CG723_05745</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">CB01635</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7 8">
            <text>(R)-N(6)-lipoyl-L-lysyl-[dihydrolipoyllysine-residue acetyltransferase] + H(+) + pyruvate = (R)-N(6)-(S(8)-acetyldihydrolipoyl)-L-lysyl-[dihydrolipoyllysine-residue acetyltransferase] + CO2</text>
            <dbReference type="Rhea" id="RHEA:19189"/>
            <dbReference type="Rhea" id="RHEA-COMP:10480"/>
            <dbReference type="Rhea" id="RHEA-COMP:10481"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:83099"/>
            <dbReference type="ChEBI" id="CHEBI:83111"/>
            <dbReference type="EC" id="1.2.4.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.2.4.1" evidence="2 8"/>
    <dbReference type="EMBL" id="NNBL01000002">
        <property type="protein sequence ID" value="PJN12535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN12535">
        <property type="protein sequence ID" value="PJN12535"/>
        <property type="gene ID" value="CG723_05745"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004739">
        <property type="term" value="F:pyruvate dehydrogenase (acetyl-transferring) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02017">
        <property type="entry name" value="TPP_E1_EcPDC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035807">
        <property type="entry name" value="PDC_E1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004660">
        <property type="entry name" value="PDH_E1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041621">
        <property type="entry name" value="PDH_E1_M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009014">
        <property type="entry name" value="Transketo_C/PFOR_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005474">
        <property type="entry name" value="Transketolase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43825:SF3">
        <property type="entry name" value="PTHR43825:SF3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17831">
        <property type="entry name" value="PDH_E1_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00456">
        <property type="entry name" value="Transketolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000156">
        <property type="entry name" value="Pyruvate_dh_E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52922">
        <property type="entry name" value="SSF52922"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00759">
        <property type="entry name" value="aceE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8 13" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0786">Thiamine pyrophosphate</keyword>
    <feature type="domain" description="TRANSKETOLASE_1" evidence="11">
        <location>
            <begin position="147"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="domain" description="PDH_E1_M" evidence="12">
        <location>
            <begin position="486"/>
            <end position="713"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="237"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="267"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="269"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00033635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR000156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000156-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF17831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PJN12535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="899" mass="98546" checksum="35574B196F812E27" modified="2018-04-25" version="1">MTDPSAIQPSELDQLPDRDPEETAEWQASLDAVTKAAGPHRAAYLMRRTLERAEGSGLALPKLLETDYVNTIPTAAEPAIEGDEALELKIAAWNRWNAAAMVTRGSKYGVGGHIATFASAAWLYETGFNHFFKGKEGDGSGDQLYIQGHASPGIYARAFLDGRLSEQQLDHFRQESGGDGLPSYPHPRRLPWLWEFPTVSMGLGPLSAIYQARFNRYLTNRKIKDVSASHVWAFLGDGEMDEPEATAALALASREGLDNLTFVINCNLQRLDGPVRANFRVVQELEAQFRGAGWNVIKTLWGSAWDELFQLDTTGALVRRLREVPDAQFQTYATRDAAYIREHFFGSEPALVELGRLLTDDKIAECFKVSRGGHEPRKVYAAYRAALSHAGAPTVILVQTVKGFTLGKGFESKNANHQMKKLTVDEFKDMRDLLELPISDSQFVDGQVPYGHPGADSPEVRYLQERRAALGGPAPARRTHAIAPLPAPADKAFASFDKGSGSQSVATTMAFVRLVKDLVRDKETGKRWVPIVPDEARTFGMESLFPSLGIYSPKGQTYEPVDRDQLMYYKEATDGQILNEGITEAGSMADFIAAASAYSTHGEAMIPFYIFYSMFGWQRTADQMWQLGDQLGRGFLVGATAGRTTLTGEGLQHADGHSPVIAATNPAALSYDPAFAYEIGAIVKDGLRRMYGEAAPGEDRDVFYYLTVYNEPMPQPAKPAGVDEGILKGLYRFNTAESAGVNVAAANAPRIQLLGSGTAIHWALEAQKLLAEEWGVAADVWSATSWTELRRDALEADEAILRGEERTPYIRTALDGAQGPVLAVSDYMRQVPDQIAQWVEQDYSSLGADGFGLSDTREAARRHFGIDAQSIVVAALAQLARRGEVNASAVKEARERYGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K0P0</accession>
    <name>A0A2M9K0P0_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Acetaldehyde dehydrogenase</fullName>
            <ecNumber evidence="3">1.2.1.10</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Acetaldehyde dehydrogenase [acetylating]</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CG723_06695</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CB01635</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>acetaldehyde + CoA + NAD(+) = acetyl-CoA + H(+) + NADH</text>
            <dbReference type="Rhea" id="RHEA:23288"/>
            <dbReference type="ChEBI" id="CHEBI:15343"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.2.1.10"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the acetaldehyde dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.10" evidence="3"/>
    <dbReference type="EMBL" id="NNBL01000002">
        <property type="protein sequence ID" value="PJN12701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN12701">
        <property type="protein sequence ID" value="PJN12701"/>
        <property type="gene ID" value="CG723_06695"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008774">
        <property type="term" value="F:acetaldehyde dehydrogenase (acetylating) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019439">
        <property type="term" value="P:aromatic compound catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01657">
        <property type="entry name" value="Ac_ald_DH_ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003361">
        <property type="entry name" value="Acetaldehyde_dehydrogenase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015426">
        <property type="entry name" value="Acetylaldehyde_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000534">
        <property type="entry name" value="Semialdehyde_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09290">
        <property type="entry name" value="AcetDehyd-dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01118">
        <property type="entry name" value="Semialdhyde_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015689">
        <property type="entry name" value="Actaldh_dh_actl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00859">
        <property type="entry name" value="Semialdhyde_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03215">
        <property type="entry name" value="ac_ald_DH_ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0058">Aromatic hydrocarbons catabolism</keyword>
    <keyword evidence="2 3" id="KW-0520">NAD</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Semialdhyde_dh" evidence="4">
        <location>
            <begin position="7"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-thioester intermediate" evidence="3">
        <location>
            <position position="128"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="13"/>
            <end position="16"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="159"/>
            <end position="167"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="286"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PJN12701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="307" mass="32077" checksum="79337A50AE863C7A" modified="2018-04-25" version="1">MTAKKATAAIVGSGNIGTDLLHKLHRSPYIEPRWMIGVDPDSAGLTRARKLGVEASHEGVGHLLAQDERPDLVFEATSAYVHRANAPRYAELGIRAIDLTPAAVGPAVVPPANLTEHLDAPNINMITCGGQATIPMVYAVSRVVPVAYAEIVASVASVSAGPGTRANIDEFTRTTSRGIEEIGGAARGKAIIILNPATETSAAGAAGPVIMRDTVFCAIPEDADRDAITLSVKEIAESVATYVPGYRLRTEPQFDNPSPMNGGMARVAIFLEVEGAGDFLPPYAGNLDIMTAAATKVGEELAKGISK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K0X0</accession>
    <name>A0A2M9K0X0_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Pseudouridine-5'-phosphate glycosidase</fullName>
            <shortName evidence="6">PsiMP glycosidase</shortName>
            <ecNumber evidence="6">4.2.1.70</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">psuG</name>
        <name evidence="7" type="ORF">CG723_07085</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CB01635</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the reversible cleavage of pseudouridine 5'-phosphate (PsiMP) to ribose 5-phosphate and uracil. Functions biologically in the cleavage direction, as part of a pseudouridine degradation pathway.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>D-ribose 5-phosphate + uracil = H2O + psi-UMP</text>
            <dbReference type="Rhea" id="RHEA:18337"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17568"/>
            <dbReference type="ChEBI" id="CHEBI:58380"/>
            <dbReference type="ChEBI" id="CHEBI:78346"/>
            <dbReference type="EC" id="4.2.1.70"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="6">Binds 1 Mn(2+) ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homotrimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the pseudouridine-5'-phosphate glycosidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.70" evidence="6"/>
    <dbReference type="EMBL" id="NNBL01000002">
        <property type="protein sequence ID" value="PJN12768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN12768">
        <property type="protein sequence ID" value="PJN12768"/>
        <property type="gene ID" value="CG723_07085"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016798">
        <property type="term" value="F:hydrolase activity, acting on glycosyl bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004730">
        <property type="term" value="F:pseudouridylate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046113">
        <property type="term" value="P:nucleobase catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1790.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01876">
        <property type="entry name" value="PsiMP_glycosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022830">
        <property type="entry name" value="Indigdn_synthA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007342">
        <property type="entry name" value="PsuG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42909">
        <property type="entry name" value="PTHR42909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04227">
        <property type="entry name" value="Indigoidine_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110581">
        <property type="entry name" value="SSF110581"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6 7" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 6" id="KW-0456">Lyase</keyword>
    <keyword evidence="3 6" id="KW-0464">Manganese</keyword>
    <keyword evidence="1 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="6">
        <location>
            <begin position="137"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="6">
        <location>
            <position position="22"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="6">
        <location>
            <position position="156"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="83"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="103"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="135"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PJN12768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="301" mass="31327" checksum="6CCCF86F0979498B" modified="2018-04-25" version="1">MVLVSDEVREAVAAGRPVVALESTIIAHGLPRPRNLRVALELEELVRAEGAVPATIAVLDGNPQVGLDKGQLERVATQDGVRKLSHRDLPLAVATGASGATTVSATALLAARAGVRVFATGGLGGVHRRWTETQDESADLGLLARTRITVVCAGVKSILDVPATLQRLETLGVSVAGYGTGRFPGFYLSDSGHPVDWTLRDPAEVAGVMRAQDALGGPETALIVANPVPEAEQLDPALHARVLDDALHACDAEGVTGQAVTPFLLDYLVRHTDGASLEANLAAVRGNVQLAARIAAAWARP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K106</accession>
    <name>A0A2M9K106_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alpha/beta hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_06735</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000002">
        <property type="protein sequence ID" value="PJN12707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN12707">
        <property type="protein sequence ID" value="PJN12707"/>
        <property type="gene ID" value="CG723_06735"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00111">
        <property type="entry name" value="ABHYDROLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="35"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN12707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="286" mass="31247" checksum="D1A5CD20934C026E" modified="2018-04-25" version="1">MNSLTYEGTSRTGKAADVTLHYHEAGPDSPDTPVVILLHGGGPGASGWSNFGRNLPVFAEHFRTLLIDQPCYGASDKPELTKDFFSFAADAVAALMNELDIPQAHFVGNSLGGGTATRMALDHPDKVGKLLLMGPGGISVNLFAPDPTEGIKKLFAFNGSGEPTRAMMRDFLTTLAYDASIVTDAFVEERYAQATDPEAKLGNDRMAASFAKWPADTMLWREAHRITAPTLLTWGREDRVNPLDGALVALKTIPDARLHVFPHCGHWAQTERFDEFNRLAVDFFRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K135</accession>
    <name>A0A2M9K135_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CG723_07415</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000002">
        <property type="protein sequence ID" value="PJN12831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN12831">
        <property type="protein sequence ID" value="PJN12831"/>
        <property type="gene ID" value="CG723_07415"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043215">
        <property type="term" value="P:daunorubicin transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1900753">
        <property type="term" value="P:doxorubicin transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005894">
        <property type="entry name" value="DrrA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01188">
        <property type="entry name" value="drrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="16"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="48"/>
            <end position="55"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PJN12831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="331" mass="35255" checksum="84B9E8DFC6CD5733" modified="2018-04-25" version="1">MPTPNLGNGQQPPAAVSTADLRKSYGDKTVLDGIDLHIPAGTVFALLGPNGAGKTTAVQILSTLISADGGQAQVAGHDVATSPEGVRAAIGVTGQFSAVDGLITGEENMFLMADLHHLSKREGRRVAAELLERFDLTDAASKPASTYSGGMKRRLDIAMTLVGNPRIIFLDEPTTGLDPRARHNMWGIIRELVSDGVTVFLTTQYLDEADELADRIAVLNDGKIAAEGTAEELKRLIPGGHIRLRFTDPDAYQAAALSLREAHRDDEALALQLPSDGSQRELRSILDWLDAAAIEADELTVHTPDLDDVFFALTGGAGVPAQPNQPKEDAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K1A4</accession>
    <name>A0A2M9K1A4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_07800</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000002">
        <property type="protein sequence ID" value="PJN12901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN12901">
        <property type="protein sequence ID" value="PJN12901"/>
        <property type="gene ID" value="CG723_07800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN12901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="61" mass="6401" checksum="5FAF9C69DA44520E" modified="2018-04-25" version="1">MNLAVIGMIAGMALGFAGYFGGFGAFLLVAALGAVGFVAGRFLEGDLEPGDFFRTRGDRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K2C8</accession>
    <name>A0A2M9K2C8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">S9 family peptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_01425</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000001">
        <property type="protein sequence ID" value="PJN13275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN13275">
        <property type="protein sequence ID" value="PJN13275"/>
        <property type="gene ID" value="CG723_01425"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008236">
        <property type="term" value="F:serine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001375">
        <property type="entry name" value="Peptidase_S9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002469">
        <property type="entry name" value="Peptidase_S9B_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00930">
        <property type="entry name" value="DPPIV_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00326">
        <property type="entry name" value="Peptidase_S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DPPIV_N" evidence="2">
        <location>
            <begin position="122"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_S9" evidence="1">
        <location>
            <begin position="490"/>
            <end position="687"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN13275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="688" mass="73952" checksum="A3574A80EA564676" modified="2018-04-25" version="1">MDDAREFPRQYARTRRFALGAPSRFTVSADGRRVLFLRTGGGADPVSALWLHEDGEERVLVNVSRTARAGDVPAAERVRRERARESAVGLVSYSADAECRTVVYALSGALWAVRVADGVPFPVSAAGPVVDPRLSPDGRSVAYVTGGALHVVTLNGEDRLLAAPEGPDITYGLTDHASSESMGRARGHWWAPDGGALLAARVDTSRVQRWYLSDPADPSAPPRAVRYPAAGTANADVSLHLLHLDGSRAEVDWDRGAFEYVPVAGWDAHGPFAAVQSRDQRTLRTLAVDPATGATRLLDEQLDAAWVELVPGAPCRTASGALVTTRDEQDTRRLVVAGKPVTPVGLQVRQVLGVQGESVLFEGGDEPTETHVWTWAPDAGCVRLTDTPGVHTAVSAGGTTVLVSRREDRTTVEVTKKGKPVGEISSLAERPVVPTRPVHLRLGERELRSQLFLPSWHTPGSGTLPVLVNPYGGQHLLVATRGLGWPAHLSQWFAEQGFAVLVTDGRGSPGRGPAWEKEIRGDILTHALDDQVSAVQAAGAQFPDLDLTRVAIRGWSFGGFLAAGAVLRRPDVFHAAVAGAPPTDQRLYDTHWKERYLGHPDEEPENYERCSLIADAPLLRRPLLLVHGLADDNVAVAHTLRLSAALLAAGRSHQVLPLPGATHMVTQEGVAENLLLFQLDFLKKSLGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-05-25" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K2L7</accession>
    <name>A0A2M9K2L7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Peptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_02000</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000001">
        <property type="protein sequence ID" value="PJN13374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN13374">
        <property type="protein sequence ID" value="PJN13374"/>
        <property type="gene ID" value="CG723_02000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046366">
        <property type="entry name" value="MPAB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018713">
        <property type="entry name" value="MPAB/Lcp_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36124">
        <property type="entry name" value="PTHR36124"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09995">
        <property type="entry name" value="MPAB_Lcp_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MPAB_Lcp_cat" evidence="2">
        <location>
            <begin position="43"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="298"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN13374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="321" mass="36885" checksum="65FA7837AE11A053" modified="2018-04-25" version="1">MQRYERLRQIRRLDPDRDWLTIYRLTATYEFPWDLTRALELALYRTYAVPSIGRLLAETGELTERPQKRYDDTSLLLDTVVEHGFDSVQGRTAIRRINQMHRSYDISNDDMRYVLCTFVVVPRRWIDAYGWRRLSRHEVIASAHYYRALGRHMGIQGIPESYEEFETCLDTYEAEHFGRDEAGRRVSDATLTLMASWYPGVLEPVLKKATVALLDEPLLRAFDYEPPSPLTRTLVRGAVRLRGRAVRLLPPRRAPHQARQNWEIRGYPNGYRVGELGTFPTPGLRGCPVPHATPGLRGCPVPHAAPPGEGSGDHRPPPRTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K3B5</accession>
    <name>A0A2M9K3B5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Sugar phosphate isomerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CG723_03140</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000001">
        <property type="protein sequence ID" value="PJN13570.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN13570">
        <property type="protein sequence ID" value="PJN13570"/>
        <property type="gene ID" value="CG723_03140"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0413">Isomerase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PJN13570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="215" mass="22673" checksum="3C76ABD9AF85D2B4" modified="2018-04-25" version="1">MTGTPPGIAALRARTDASLGETARTWLDKSTAEAAADGAGGQQAQAVWELRFAEAGRRCGAEHADSARIVLLHAARADTATLTRLYEQGAAAERRAVLAALPHLVPGPEALSLVEDALRTNDTRLVAAAVGPYAAEHLTAHHWRHAVLKCLFTGVPVSAVADLAERARGDAELARMLGDYARERTAAGRPVPDDLHRVLALTPLVVPPPPKAEES</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K3I5</accession>
    <name>A0A2M9K3I5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">LLM class F420-dependent oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_03585</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000001">
        <property type="protein sequence ID" value="PJN13640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN13640">
        <property type="protein sequence ID" value="PJN13640"/>
        <property type="gene ID" value="CG723_03585"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019951">
        <property type="entry name" value="F420_OxRdatse_Rv3520c_pred"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011251">
        <property type="entry name" value="Luciferase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036661">
        <property type="entry name" value="Luciferase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00296">
        <property type="entry name" value="Bac_luciferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51679">
        <property type="entry name" value="SSF51679"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03559">
        <property type="entry name" value="F420_Rv3520c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bac_luciferase" evidence="1">
        <location>
            <begin position="8"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN13640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="341" mass="36312" checksum="D24EF580310538D6" modified="2018-04-25" version="1">MELSAPLAYAADPRQAADDAAALESAGLDAVWVAEAYGFDSPTIMGYLAARTERMKIGAAILNVYSRTPALIAQTAAGLDAVSGGRAIIGLGASGPQVVEGWHGKAYDKPLGRTRETIELTRRILRREVIDHHGITDMPLPPEKGGRLGKPLKILSKPVRPEVPLYVASLGPANVRMTAEIADGWLPTLFIPEKAHQVWGTPLAEGAAKRAPELGPLQVVAGGLLAIGEDAAAARDLARPNIALYVGGMGAVGKNFYNDLAVAYGYEKEAKLIQELYLSGKKKEAEAAVPDEFCELMSLCGPESYVRERVEAFRAAGVTMLNVIPVGPDPARLVETVKNWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K3L0</accession>
    <name>A0A2M9K3L0_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">2-amino-3-ketobutyrate coenzyme A ligase</fullName>
            <shortName evidence="1">AKB ligase</shortName>
            <ecNumber evidence="1">2.3.1.29</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Glycine acetyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">kbl</name>
        <name evidence="4" type="ORF">CG723_03945</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CB01635</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the cleavage of 2-amino-3-ketobutyrate to glycine and acetyl-CoA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>acetyl-CoA + glycine = (2S)-2-amino-3-oxobutanoate + CoA</text>
            <dbReference type="Rhea" id="RHEA:20736"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:78948"/>
            <dbReference type="EC" id="2.3.1.29"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
        <text evidence="1">Binds 1 pyridoxal phosphate per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid degradation; L-threonine degradation via oxydo-reductase pathway; glycine from L-threonine: step 2/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.29" evidence="1"/>
    <dbReference type="EMBL" id="NNBL01000001">
        <property type="protein sequence ID" value="PJN13699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN13699">
        <property type="protein sequence ID" value="PJN13699"/>
        <property type="gene ID" value="CG723_03945"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00046">
        <property type="reaction ID" value="UER00506"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008890">
        <property type="term" value="F:glycine C-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044249">
        <property type="term" value="P:cellular biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019518">
        <property type="term" value="P:L-threonine catabolic process to glycine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00985">
        <property type="entry name" value="2am3keto_CoA_ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011282">
        <property type="entry name" value="2am3keto_CoA_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001917">
        <property type="entry name" value="Aminotrans_II_pyridoxalP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01822">
        <property type="entry name" value="2am3keto_CoA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00599">
        <property type="entry name" value="AA_TRANSFER_CLASS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotran_1_2" evidence="3">
        <location>
            <begin position="46"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="region of interest" description="Pyridoxal phosphate binding" evidence="1">
        <location>
            <begin position="114"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Pyridoxal phosphate binding" evidence="1">
        <location>
            <begin position="211"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Pyridoxal phosphate binding" evidence="1">
        <location>
            <begin position="242"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Pyridoxal phosphate binding; shared with dimeric partner" evidence="1">
        <location>
            <begin position="275"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="154"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="139"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="186"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="369"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="1">
        <location>
            <position position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PJN13699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="404" mass="43046" checksum="ECCB46192CC1278A" modified="2018-04-25" version="1">MFNSVREDIQATLDEIAAAGLHKPERVIGTPQSATVAVTAGGRPGEVLNFCANNYLGLADHPEVIAAGHEALDRWGYGMASVRFICGTQEVHKELEARLSAFLGQEDTILYSSCFDANGGVFETLLGEEDAVISDALNHASIIDGIRLSKARRLRYANRDLADLEQQLKEAQSARRRLIVTDGVFSMDGYVAPLREICDLADRYDAMVMVDDSHAVGFVGPGGRGTPELHGVMDRVDIITGTLGKALGGASGGYVAARAEIVALLRQRSRPYLFSNSLAPVIAAASLKVLDLLESAGELRERLAANTALFRTRMAQEGFDILPGDHAIAPVMIGDASVAGRMAELLLERGVYVIGFSYPVVPQGKARIRVQLSAAHSTGDVNRAVDAFVAARAELDGESAGAVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K3N3</accession>
    <name>A0A2M9K3N3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">SsgA family sporulation/cell division regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CG723_03550</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CB01635</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell septum</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SsgA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000001">
        <property type="protein sequence ID" value="PJN13637.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN13637">
        <property type="protein sequence ID" value="PJN13637"/>
        <property type="gene ID" value="CG723_03550"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030428">
        <property type="term" value="C:cell septum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030435">
        <property type="term" value="P:sporulation resulting in formation of a cellular spore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.31.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006776">
        <property type="entry name" value="SsgB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038658">
        <property type="entry name" value="SsgB_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04686">
        <property type="entry name" value="SsgA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4" id="KW-0132">Cell division</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0749">Sporulation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PJN13637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="138" mass="15147" checksum="0A75DB1C261B610F" modified="2018-04-25" version="1">MSTVIEQAVEARLVAAAPRMSTIPATLRYDIRDPFAVRMSFPAPATLEGVDVSWTFARELLAAGVREPAGAGDVRVRPYGYDRTVLEFHAHEGTAIVHIRTGELRRFLSSTAAMVPVGDEHLHVDLDGDLAELMRDAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JFE5</accession>
    <name>A0A2M9JFE5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">LysR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_43740</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LysR transcriptional regulatory family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000044">
        <property type="protein sequence ID" value="PJN05615.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN05615">
        <property type="protein sequence ID" value="PJN05615"/>
        <property type="gene ID" value="CG723_43740"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005119">
        <property type="entry name" value="LysR_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000847">
        <property type="entry name" value="Tscrpt_reg_HTH_LysR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00126">
        <property type="entry name" value="HTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03466">
        <property type="entry name" value="LysR_substrate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00039">
        <property type="entry name" value="HTHLYSR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50931">
        <property type="entry name" value="HTH_LYSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH lysR-type" evidence="2">
        <location>
            <begin position="3"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN05615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="299" mass="32485" checksum="12F354DD82878A5C" modified="2018-04-25" version="1">MDLDLRKLRYFAAVADQLHFGRAADELHIAQPVLSRQIRALEQDLGASLFTRDRHGVALTDAGRQLLADAGPLLASAHAVRRRVSVAARGSRRLMVGFRAGIPVIPAARAFEARHPDVVVDVQRIEGDDQAAMLLDGRIDVGYVRLPIDEAGLRVTPLYTEPRVAVLPAGHRLAGKEEVTEADLAGEPLVWHADPSTQPTRRRHPNAGYLVRGVDETLEHVAAGRGISFLARSASVFYSHPEVIYVPIPDLAPDQVCLATAASRTSPVVDDFFTAAQATAEITAECGNYEMWQLGSKRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JFH9</accession>
    <name>A0A2M9JFH9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Hydroxyacid dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_44075</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000045">
        <property type="protein sequence ID" value="PJN05582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN05582">
        <property type="protein sequence ID" value="PJN05582"/>
        <property type="gene ID" value="CG723_44075"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006140">
        <property type="entry name" value="D-isomer_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02826">
        <property type="entry name" value="2-Hacid_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="2-Hacid_dh_C" evidence="1">
        <location>
            <begin position="112"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN05582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="327" mass="35134" checksum="8B85BBE59EE519CC" modified="2018-04-25" version="1">MTTSISAFTLVMVPPLSAETRAWPDRLRKTVPGITVLSPEDPDAVRAALARADAAYGTLTPELLGITQQLRWLQAPQAGPPPGFYHTDLVRHPAQVTNMRDTYTDHVAHHTVALVLALARQLPRYVREQAAGHWAPDWSDGAVVPLAEAHALVVGTGAVGAEAGRLLAAFGTHVEGVDPRVTEAPPGFSRVLTPDHLDRALGRADLVILTVPHTPSTEGLMDADRLAAMKPGSCLVNVGRGPTVRLDDLVAALDSGHLRGAALDVFEREPLPEDHPLWRHPAAVITPHVAGAGPHAAQRRFEVLAENAQRFADGRPLINVVDKTQWF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JFR2</accession>
    <name>A0A2M9JFR2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CG723_44110</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000045">
        <property type="protein sequence ID" value="PJN05587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN05587">
        <property type="protein sequence ID" value="PJN05587"/>
        <property type="gene ID" value="CG723_44110"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PJN05587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="154" mass="16909" checksum="35E472DFD29471AF" modified="2018-04-25" version="1">MDWGTLLPTLVGAVIGVGSTLGADRLRWARELRQRATSSRQELYGQFLTALNEAAESLWVLGLGDRHDSSIDLPEALRAAVHGTGLYSFREQVMIIATDDVLAKADQAVDRVREYRDCLAAGHREGSPDEVAGMDAYKRAVKELRSAMRADLIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JH52</accession>
    <name>A0A2M9JH52_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">LysR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_41365</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LysR transcriptional regulatory family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000036">
        <property type="protein sequence ID" value="PJN06087.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN06087">
        <property type="protein sequence ID" value="PJN06087"/>
        <property type="gene ID" value="CG723_41365"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005119">
        <property type="entry name" value="LysR_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000847">
        <property type="entry name" value="Tscrpt_reg_HTH_LysR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00126">
        <property type="entry name" value="HTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03466">
        <property type="entry name" value="LysR_substrate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00039">
        <property type="entry name" value="HTHLYSR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50931">
        <property type="entry name" value="HTH_LYSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH lysR-type" evidence="2">
        <location>
            <begin position="7"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN06087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="307" mass="33253" checksum="3C472712D61A2C70" modified="2018-04-25" version="1">MFNDISLTKRLLEQFLVVADEKHFGRAAERLGMSQPPLSQSIQRLERGLDVRLFERGPGGVRLTPAGAAFVVDARRLLDAQEAAIERVRRVAGGLEGDIRVGYVTIVSHLYVPRLLRAVAEELPGLRVHLHQDSSAAIAEKVRSGTLDLGYLRDTSVLSSDLASEVFAVERLTAALPQDHPLAEADAIGLEALRDQDFVLPSVTVLPALAEQVQLACRQAGFTPRRRAVADDLSGLLSYVASGLCVSLLSEGLRDFGVPGIAFVPVQGSSPYLETTVFAVYRPDADAAVLRLLEAIGRAQRHDPPRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-05-25" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JH57</accession>
    <name>A0A2M9JH57_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">LacI family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CG723_40040</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000033">
        <property type="protein sequence ID" value="PJN06214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN06214">
        <property type="protein sequence ID" value="PJN06214"/>
        <property type="gene ID" value="CG723_40040"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01392">
        <property type="entry name" value="HTH_LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000843">
        <property type="entry name" value="HTH_LacI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046335">
        <property type="entry name" value="LacI/GalR-like_sensor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00356">
        <property type="entry name" value="LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13377">
        <property type="entry name" value="Peripla_BP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00354">
        <property type="entry name" value="HTH_LACI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50932">
        <property type="entry name" value="HTH_LACI_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH lacI-type" evidence="4">
        <location>
            <begin position="16"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PJN06214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="345" mass="37141" checksum="C9C5A67A82E16D74" modified="2018-04-25" version="1">MDRTARRPDSRYGNRPTMKDVAARAGVGLKTVSRVVNGEPGVTPDTERRVQEAIEALGFRRNDSARVLRKGRTASIGLVLEDLADPFYGPLSRAVEEVARAHGALLINGSSAEDPEREQELVLALCARRVDGLVVIPAGDDHRYLEPEIAAGVATVFVDRPAGKIDADVVLSDSFGGARDGVAHLIAHGHRRIGFIGDQPRIHTAAERLRGYRTAMEDAGIVVEDAWMSLGVTDPERVRRAAEEMLAGPEPVTAIFAGNNRVTVTVVRVLSEVTRPVALVGFDDIELGDLLRPGVTVVAQDAAQLGRTAAERLFRQLDGLSVAPERIELPTRLITRGSGELPPAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JHA4</accession>
    <name>A0A2M9JHA4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MOSC domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_40290</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000033">
        <property type="protein sequence ID" value="PJN06260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN06260">
        <property type="protein sequence ID" value="PJN06260"/>
        <property type="gene ID" value="CG723_40290"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030151">
        <property type="term" value="F:molybdenum ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005302">
        <property type="entry name" value="MoCF_Sase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005303">
        <property type="entry name" value="MOSC_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011037">
        <property type="entry name" value="Pyrv_Knase-like_insert_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03473">
        <property type="entry name" value="MOSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03476">
        <property type="entry name" value="MOSC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50800">
        <property type="entry name" value="SSF50800"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51340">
        <property type="entry name" value="MOSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MOSC" evidence="1">
        <location>
            <begin position="127"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN06260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="274" mass="29786" checksum="204957D668116473" modified="2018-04-25" version="1">MPNASLHSIHIHPLKSVRGRAPREAAVELWGLAGDRRWVLIDASGKVVTQRQHPRLALTSAETPDGDGLRMSAPGRAPLTVPVPRPAGRTTVNIFGDKVEAVPADDAAHTWWSAHLEADVRLVHLDDPATRRPIDPEYAKPGETVSFADGYPLLLTTLSSLDALNSLIAQGDHADEGPLPMNRFRPNVVVDGTAPWAEDDWSRISIGDVTFRITKKSGRCVVTTTNQSTSERGKEPLRTLARHRRFGDQLCFGTNLVPETTGTVRIGDAITILG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JHX5</accession>
    <name>A0A2M9JHX5_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cysteine desulfurase</fullName>
            <ecNumber evidence="4">2.8.1.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CG723_38745</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CB01635</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[sulfur carrier]-H + L-cysteine = [sulfur carrier]-SH + L-alanine</text>
            <dbReference type="Rhea" id="RHEA:43892"/>
            <dbReference type="Rhea" id="RHEA-COMP:14737"/>
            <dbReference type="Rhea" id="RHEA-COMP:14739"/>
            <dbReference type="ChEBI" id="CHEBI:29917"/>
            <dbReference type="ChEBI" id="CHEBI:35235"/>
            <dbReference type="ChEBI" id="CHEBI:57972"/>
            <dbReference type="ChEBI" id="CHEBI:64428"/>
            <dbReference type="EC" id="2.8.1.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. NifS/IscS subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.8.1.7" evidence="4"/>
    <dbReference type="EMBL" id="NNBL01000029">
        <property type="protein sequence ID" value="PJN06485.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN06485">
        <property type="protein sequence ID" value="PJN06485"/>
        <property type="gene ID" value="CG723_38745"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031071">
        <property type="term" value="F:cysteine desulfurase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044571">
        <property type="term" value="P:[2Fe-2S] cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044249">
        <property type="term" value="P:cellular biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000192">
        <property type="entry name" value="Aminotrans_V_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010240">
        <property type="entry name" value="Cys_deSase_IscS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016454">
        <property type="entry name" value="Cysteine_dSase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11601:SF34">
        <property type="entry name" value="PTHR11601:SF34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00266">
        <property type="entry name" value="Aminotran_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005572">
        <property type="entry name" value="NifS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="7" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminotran_5" evidence="8">
        <location>
            <begin position="3"/>
            <end position="371"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PJN06485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="389" mass="40367" checksum="642E2E5DE373A2FB" modified="2018-04-25" version="1">MAYLDHAATTPMLPEAVEVMTAQLALTGNASSLHAAGRRARRTVEESRETLAESLGARPSEVVFTSGGTEADNLAVKGLYWSRRDADPARTRVLASPVEHHAVLDAVHWLGEHEGATVEYLPVDAYGRVHPDALREAIARNPDDVALATVMWANNEIGTIQPVRELADVAAEFGVPLHADAVQAFGQIPVDFAASGLAAMTVSGHKIGGPYGIGALLLGREYTPVPVLHGGGQERHVRSGTLDVPAVAAFAVAGRLAAEQREWFAREIGGLRDGLVDAVRAAVPEAILGGDPAPGGRLPANAHFTFPGCEGDSLLLLLDAQGIECSTGSACTAGVAQPSHVLLATGTDPDLARGTLRFSLGHTSTEADVAAVADAIGPAVERARTAGLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JI63</accession>
    <name>A0A2M9JI63_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">FUSC-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CG723_39305</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000030">
        <property type="protein sequence ID" value="PJN06447.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN06447">
        <property type="protein sequence ID" value="PJN06447"/>
        <property type="gene ID" value="CG723_39305"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032692">
        <property type="entry name" value="YccS_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12805">
        <property type="entry name" value="FUSC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="26"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="123"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="149"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="411"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="459"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="488"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="domain" description="FUSC-like" evidence="3">
        <location>
            <begin position="81"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="680"/>
            <end position="733"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="685"/>
            <end position="705"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PJN06447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="733" mass="78113" checksum="25876EC4C8AC16AE" modified="2018-04-25" version="1">MTWLRALGLIVRSGLTIERTRLEPLVALRAAAGVATVIGLALWLVSPAYATSAAFGAFSAGAATFQRSWRPRKVLALAAGAGLALSTFLGYLVGAHPVPFLLLLALWSFGAGMAWAAGSTAGIVAATTIGIMLVTITLPTTVVQALEHAAVIAFGGVVQATLILLFPIRRWGAHRDALADALAAVADYARRLRHDPVAPFAPEPMMTARDAAAVTPWQARRRPAALNGPRGLAERIRPVLASLADPRVGAPAEGPERDRTRELLKAAGEVLDATAHSIRRGTPVQVPSEAMEALGGGEEEVLRGPARLAAVRLFDLLREVVEIADSGDTHAANAPALVRPTMFRMVPVVLRAMCRELTRDSTVLRHAVRLAGVACLGYLLGNALPLGHGYWVPITSVMVLRPDFHQTYSRAVARFAGTFVGVGLATGVVQLAHPGAYLSGGLAVFSAGLMYLLMRTGYAVSQSFAAAYVVFLLGMGGEEWHQTVRDRVLLTLLGGALAMLAYVVFPAWETPRLLDRLADWLAANGRYAAAVVGSYADPGGGHRAEVRQALLAARKKEAAWDEAFERSKQEPVKHRGLTRSAAQDAYEALKSIGRAAMLLEAHLPGRGVRPVPEAALFAAALRADTARAARDVRERRAPGWERVAAALDAWEGADGGDDPVVRRGAELLLGALEELTAALDTTPLERDVESVREAREDRQERTAPEDEAADAEEEQELRRRRGDGPTPPPKDGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JIE9</accession>
    <name>A0A2M9JIE9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_38605</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000028">
        <property type="protein sequence ID" value="PJN06622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN06622">
        <property type="protein sequence ID" value="PJN06622"/>
        <property type="gene ID" value="CG723_38605"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014825387" evidence="1">
        <location>
            <begin position="30"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN06622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="94" mass="9676" checksum="0B421A2A645B6308" modified="2018-04-25" version="1">MSVARRSLLTATAAGTLLAALWFVPSATATPEKTAEADQQQTATAVHTQAEGQLRLADTGTVDTTPYVIGGSTFLGIGAGFLTYSARKSRAAAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JIH9</accession>
    <name>A0A2M9JIH9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Acyl-CoA synthetase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_38015</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000027">
        <property type="protein sequence ID" value="PJN06674.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN06674">
        <property type="protein sequence ID" value="PJN06674"/>
        <property type="gene ID" value="CG723_38015"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-binding" evidence="1">
        <location>
            <begin position="33"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding_C" evidence="2">
        <location>
            <begin position="467"/>
            <end position="542"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN06674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="555" mass="59825" checksum="7A4AD160CCDA6DFA" modified="2018-04-25" version="1">MSSSIYAAQPWLGRLSEAQRAPVTPADSVLHAFRAAVRTAPDRTAVAYFDGRLSYRELDELSDSVAGHLAARGLGRGDRAALMLQNSPHFVIGLLAAYKAGATVVPVNPMYKSGEVTHVLHDADVTALICSDRAWETYLRETAADSSVRIVLTACELDLQTRGDERVLKFERVEPQAEDADDLLTVARQGNAAPEGRDPRPDDIALISYTSGTSGTPKGATNLHRNITYNAERQRTGLGIPEGGTYFGLAPLFHITGMVCELVSSFANTGTLVLAYRFEAGVVLDAFAEHRPAYTVGPSTAFMALAAHPAATREHFASFRSISSGGAPVPPALVEKFRAGFGPYIHNGYGLTECTAPCASVPPGKEAPVDPVSGTLAVGVPGPESVVRIVDDLGQEVPFGEQGEIAVRGPQVVPGYWKRPDATAESFPDGELRTGDIGFMDADGWLYVVDRKKDMINASGFKVWPREVEDVLYTHEAVREAAVVGVPDPYRGETVRAYVSLRPGASVGPDDLSAYCKERLAAYKYPREVEILPELPKTTSGKILRRELRSRTQNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JII8</accession>
    <name>A0A2M9JII8_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Glucose-6-phosphate 1-dehydrogenase</fullName>
            <shortName evidence="5">G6PD</shortName>
            <ecNumber evidence="5">1.1.1.49</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">zwf</name>
        <name evidence="10" type="ORF">CG723_38165</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CB01635</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the oxidation of glucose 6-phosphate to 6-phosphogluconolactone.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>D-glucose 6-phosphate + NADP(+) = 6-phospho-D-glucono-1,5-lactone + H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:15841"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:57955"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:61548"/>
            <dbReference type="EC" id="1.1.1.49"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="5">Carbohydrate degradation; pentose phosphate pathway; D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage): step 1/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the glucose-6-phosphate dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.49" evidence="5"/>
    <dbReference type="EMBL" id="NNBL01000027">
        <property type="protein sequence ID" value="PJN06701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN06701">
        <property type="protein sequence ID" value="PJN06701"/>
        <property type="gene ID" value="CG723_38165"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00115">
        <property type="reaction ID" value="UER00408"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004345">
        <property type="term" value="F:glucose-6-phosphate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006006">
        <property type="term" value="P:glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006098">
        <property type="term" value="P:pentose-phosphate shunt"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00966">
        <property type="entry name" value="G6PD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001282">
        <property type="entry name" value="G6P_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019796">
        <property type="entry name" value="G6P_DH_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022675">
        <property type="entry name" value="G6P_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022674">
        <property type="entry name" value="G6P_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23429">
        <property type="entry name" value="PTHR23429"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02781">
        <property type="entry name" value="G6PD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00479">
        <property type="entry name" value="G6PD_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000110">
        <property type="entry name" value="G6PD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00079">
        <property type="entry name" value="G6PDHDRGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00871">
        <property type="entry name" value="zwf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00069">
        <property type="entry name" value="G6P_DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="1 5" id="KW-0313">Glucose metabolism</keyword>
    <keyword evidence="2 5" id="KW-0521">NADP</keyword>
    <keyword evidence="3 5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="G6PD_N" evidence="8">
        <location>
            <begin position="28"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="domain" description="G6PD_C" evidence="9">
        <location>
            <begin position="213"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="484"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="496"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="5">
        <location>
            <position position="264"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="65"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="107"/>
            <end position="108"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="172"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="202"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5 6">
        <location>
            <position position="206"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="240"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="259"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="362"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022526"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PJN06701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="510" mass="57476" checksum="52604599CDAA7CE6" modified="2018-04-25" version="1">MSTTAWQNPLRDPRDRRLPRIAGPSGLVIFGVTGDLSRKKLMPAVYDLANRGLLPPGFSLVGFARRDWEDQDFAQVVHDAVREHSRTEFREEVWQQLAEGMRFIPGDFDDDTAFKQLREAVDDLDEKRGTSGNYAFYLSVPPKFFPQVVQQLKKHGLADGPEGSWRRAVIEKPFGHDLASARELNAIVHDVFAPDQVFRIDHYLGKETVQNILALRFANQMYEPVWNRSYVDHVQITMAEDIGIGGRAGYYDGIGAARDVIQNHLLQLMALTAMEEPASFDAESLLTEKLKVLKSVRLPENLGEHTVRAQYAAGWQGGEKVPGYLQEDGIDPKSKTDTYAAVKLSVDNRRWAGVPFYLRTGKRLGRRVTEIAVVFQRAPHSPFDSTATEELGQNAVVIRVQPDEGMTVRFGSKVPGTSMEIRDVSMDFAYGESFTESSPEAYERLILDVLLGDANLFPRTEEVEESWKILDPIEGHWDTHGRPAQYASGSWGPKEADEMLARDGRSWRRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JIX5</accession>
    <name>A0A2M9JIX5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">NADH-quinone oxidoreductase subunit M</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CG723_37660</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CB01635</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 3">Membrane</location>
            <topology evidence="1 3">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the complex I subunit 4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000026">
        <property type="protein sequence ID" value="PJN06802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN06802">
        <property type="protein sequence ID" value="PJN06802"/>
        <property type="gene ID" value="CG723_37660"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042773">
        <property type="term" value="P:ATP synthesis coupled electron transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010227">
        <property type="entry name" value="NADH_Q_OxRdtase_chainM/4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003918">
        <property type="entry name" value="NADH_UbQ_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001750">
        <property type="entry name" value="ND/Mrp_mem"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43507">
        <property type="entry name" value="PTHR43507"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00361">
        <property type="entry name" value="Proton_antipo_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01437">
        <property type="entry name" value="NUOXDRDTASE4"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01972">
        <property type="entry name" value="NDH_I_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="43"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
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        </location>
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            <end position="178"/>
        </location>
    </feature>
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            <end position="208"/>
        </location>
    </feature>
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            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="267"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="301"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="333"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="359"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="408"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="449"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="domain" description="Proton_antipo_M" evidence="5">
        <location>
            <begin position="156"/>
            <end position="440"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PJN06802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="532" mass="55580" checksum="E4354C7ECFBF0D0C" modified="2018-04-25" version="1">MIDISESVMQFLLALIVVGPLIGAAAALLPAPPGLKGKSPDQAVLRHGVTVTGVILIAAIVLALGFDHDHPSKMQATTDISWIPALDVRIHLGTDGISLPLLVLTALLTFLCALYSYFKQQHQRLTPRATGPSPKAFVALILVLESGTLATFAVLDLLLFFLAFEMVLIPMYFLIARWGGEQRAKAAWKFILFTLLGSVVMLLGLLLIGLKSGTFDMVALASDNGRGLSTSVQVTAVLAIGIGLAVKTPMWPLHSWLPDAHTAAPTVGSVLLAGVLLKMGTYGFVRILLPITPDGMHTFAPYLAAFAVVGIIYGSLACLALARPGAKGDLKRLIAYSSVGHMGFVLLGISTMSPTGVNGALFANIAHGLITGLLFFLVGALKDRTGSTDLDTLAQQGGMALYGKAPRLGGLLAFAAVASLGLPGLAGFWGEMLALFGAFKPAAGLSRPAFLTFMAIAAFGTLLTAAYMLAVVRRVCMGPHEAEAPKLADVQGYEFAAWTPLVALTVVGGLWPAALIGLTDPAVQKLLAGGIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JIY0</accession>
    <name>A0A2M9JIY0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_36745</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000025">
        <property type="protein sequence ID" value="PJN06834.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN06834">
        <property type="protein sequence ID" value="PJN06834"/>
        <property type="gene ID" value="CG723_36745"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027304">
        <property type="entry name" value="Trigger_fact/SurA_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109998">
        <property type="entry name" value="SSF109998"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014670474" evidence="2">
        <location>
            <begin position="32"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="203"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN06834.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="228" mass="24776" checksum="7E398E3A918E57C9" modified="2018-04-25" version="1">MHRRKSSNSRRTAFVLSTAAVAAVPLLTACGSDAHPGAAAVVGSDRITVSQLENRVNEVRDAQQAATKDDQQYEQAIAKSGGLTRNTLHSMVFDRVLHRAAADAGVTVTRRQIQERKAAMAQQAGGARQLELALLEQYSIAPERIADSARTDLEVMGLAQKVGANMQSQSETDQAPFWKALDQASKELNVDLNPRYGTWDIAKSHGRADAKTPWVREVTSPKTEQQTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JIZ9</accession>
    <name>A0A2M9JIZ9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Histidine ammonia-lyase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_36865</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000025">
        <property type="protein sequence ID" value="PJN06856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN06856">
        <property type="protein sequence ID" value="PJN06856"/>
        <property type="gene ID" value="CG723_36865"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016841">
        <property type="term" value="F:ammonia-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="CDD" id="cd00332">
        <property type="entry name" value="PAL-HAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001106">
        <property type="entry name" value="Aromatic_Lyase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008948">
        <property type="entry name" value="L-Aspartase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10362">
        <property type="entry name" value="PTHR10362"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00221">
        <property type="entry name" value="Lyase_aromatic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48557">
        <property type="entry name" value="SSF48557"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="505"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="513"/>
            <end position="527"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN06856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="527" mass="55014" checksum="CA6370E8CF804CCC" modified="2018-04-25" version="1">MSSHIADTAGKPRMTATPGLTPVVVLDGHGLPVPDVVRLADSAARPVPGTDAMKRVEESWNAAREIAAWGRVYGRSTGVGANRNEDVPTEAAADHGLRLLRSHAGAIGDELPARQVRAMLAVRANQLLAGGAGLRPTVVTALCEALETGAYPVVNEFGSVGTGDIAALAQMGLALAGEHPWRGDGAPDAQPLDNNDALALISSNALTLGQSALALHELRDLISATQLVAALSLLAVDGSYEAYALPVHEARHHRGSYAVAARMRAILGAPERPTPPLGRIQDPYGFRCVPQIHGPAQDAADALEDVLTVEINAAAENPLISPQDMAAYHHGGFYMAQLALALDHFRLAIAQVARLSTSRLSTLNEPAYTRLRPFLADGEPASSGVMILEYAAGAALGDLRAFAAPASLGHAVLSRGVEEQASFASLAARQTLRICDAYRLVVGCELVAAVRALRQRDMHPDPELPVGRAFALADTVLDQDATDRPLTEDVTRAAAGLLDSFTRIADGTDGPATATATAGSDRPGGTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JJ46</accession>
    <name>A0A2M9JJ46_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CG723_37060</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CB01635</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LytR/CpsA/Psr (LCP) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000025">
        <property type="protein sequence ID" value="PJN06889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN06889">
        <property type="protein sequence ID" value="PJN06889"/>
        <property type="gene ID" value="CG723_37060"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027381">
        <property type="entry name" value="LytR/CpsA/Psr_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004474">
        <property type="entry name" value="LytR_CpsA_psr"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13399">
        <property type="entry name" value="LytR_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03816">
        <property type="entry name" value="LytR_cpsA_psr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00350">
        <property type="entry name" value="lytR_cpsA_psr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="51"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="domain" description="LytR_cpsA_psr" evidence="4">
        <location>
            <begin position="137"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="domain" description="LytR_C" evidence="5">
        <location>
            <begin position="405"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="383"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="383"/>
            <end position="400"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF03816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF13399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PJN06889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="537" mass="57688" checksum="3C58E0EBB4C5BC08" modified="2018-04-25" version="1">MRQSSVRDSRHAAGGPDGGQGRVPKQAQGDGGRPRGHRRGGARPRRRKHRILRWFSIALAVLVLGTAGAGYLWYEHLNSNIKTDKLNIGEHQAAKPTPNAAGQTPLNILLIGSDARDSKANQKLGGAKETFGGVPLADVQMLVHLSADRTNMSVVSMPRDTLLRLPKCTDPKTGTEYPATVGRQMTNQSLGRGGPGCTVATWELLTGIHIDHFMMVDFAGVVSMADAIGGVPVCVDANILSKDSQGHGSGLKLAKGTHPVKGKQALQWLRTRYGFEDGSDIARTKAQHMYMNSMVRQMRENATITNPGKLRTLAEEATKALRVDEGLDTVKKLYDLSNELKKPAPDRITMTTMPFVYVGARVAPKPGDADKLFRLVREDVALDGKDKKKAPPKESDDPAAPDGEIAVQVQNGTRTAQLPAASGRASTVSQILVTKGFTKASADQSVSLSEEKTVIRFPSVDLEGDAQRVAKSLGVPLSSVKKSTGVSGVTLIVGDDWREGNTYPKSSKDDDTTPDTALALNGSDTKACMKVNKNFTW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JJ73</accession>
    <name>A0A2M9JJ73_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Abhydrolase_3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_36075</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000024">
        <property type="protein sequence ID" value="PJN06924.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN06924">
        <property type="protein sequence ID" value="PJN06924"/>
        <property type="gene ID" value="CG723_36075"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013094">
        <property type="entry name" value="AB_hydrolase_3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07859">
        <property type="entry name" value="Abhydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Abhydrolase_3" evidence="1">
        <location>
            <begin position="2"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN06924.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="136" mass="14507" checksum="998AF0B1CD98B620" modified="2018-04-25" version="1">MRQRGLPQPLQLVLISPVLDVSKANPAIASIARYDRVLSVEGSTIGGRLYAGERGRKDPLVSPLYADLTGLAPTAVFTGTHDIHNPDARDFAARARDAGVALEYHEEPGNQHAYALLPTSEGAAARNLITALVANR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JJA6</accession>
    <name>A0A2M9JJA6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Alpha-mannosidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CG723_36380</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CB01635</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 38 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000024">
        <property type="protein sequence ID" value="PJN06966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN06966">
        <property type="protein sequence ID" value="PJN06966"/>
        <property type="gene ID" value="CG723_36380"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004559">
        <property type="term" value="F:alpha-mannosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006013">
        <property type="term" value="P:mannose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041147">
        <property type="entry name" value="GH38_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011682">
        <property type="entry name" value="Glyco_hydro_38_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015341">
        <property type="entry name" value="Glyco_hydro_38_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037094">
        <property type="entry name" value="Glyco_hydro_38_cen_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000602">
        <property type="entry name" value="Glyco_hydro_38_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027291">
        <property type="entry name" value="Glyco_hydro_38_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028995">
        <property type="entry name" value="Glyco_hydro_57/38_cen_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09261">
        <property type="entry name" value="Alpha-mann_mid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17677">
        <property type="entry name" value="Glyco_hydro38C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07748">
        <property type="entry name" value="Glyco_hydro_38C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01074">
        <property type="entry name" value="Glyco_hydro_38N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00872">
        <property type="entry name" value="Alpha-mann_mid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="SSF74650"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88688">
        <property type="entry name" value="SSF88688"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="SSF88713"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha-mann_mid" evidence="5">
        <location>
            <begin position="520"/>
            <end position="598"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PJN06966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="1009" mass="110596" checksum="ADACD1D7F97CF4DF" modified="2018-04-25" version="1">MHDDRSLIEDRLRRVLEERIRPAVYPETVPLDVRVWHAPDEPVPVAEGLAAPALSIGEGARWGRPWGTSWFTVTGTVPQQWAGRTVEALIDLGFDGHGGPGFQCEGLVYEPDGTPVKGLHPRNHWVRVGAPAAGGQQVELRVEAASNPGFFNSRAFKPTWLGDTDTAGHDPLYTLGRVELAVFDETVWELLHDLEVLGQLMAELPLDRARRWEILHAVGAALDVVDLGEVNGTAQAARDVLAPVLDTPAGPSAHRISAVGHAHIDSAWLWPLRETVRKVARTASNMTQLLDSEPDFVFTMSQAQQLAWIKEHRPEVYAKVKKAVAEGRFVPTGGMWVESDTNMPGSEAMARQFVHGKRFFLDEFGIENEEVWLPDTFGFAAGLPQIIREAGSKWLLTQKISWSQTNTFPHHTFNWEGIDGSRVLTHFPPVDTYNCAMEGRELAHAERNFKDKGRASRSLAPTGFGDGGGGTTREMVARARRLRSLDGSPTVEWEAPAAFFEKAEAEYTDPAVWVGELYLELHRATLTSQAQTKQGNRRCEHLLQEAELWAATAAVQCEFPYPYEELDRLWKTVLLHQFHDILPGSSIAWVHREARATYARVTTELEEIVDAAQRALAGRGTGVLRFNSAPHGRSSVPALGAAGPQPADLAATTVRERDGGGFVLDNTTLRAEIDGRGLVVSLVHLASGRETLAPGRAAGLLQLHPDLPNKWDAWDVDKFYRNTGTDLTDVDALTATADGVQVTRSFGKSVAAQTFTLSPGSGRLDVATEVEWHETEKFLKLAFPLDVHAERYASETQFGHVYRPTHTNTSWEAARFEACNHRFVHLAEPGWGVALVTASTYGHDVTRTVREDRGTTTTVRASLLRAPRFPDPETDQGTHRFRHALVPGAAVGDAVREGAALSLPEREVTGTARAEVAPLVHVDHESVVLSAVKLADDGSGDVVVRFYETRGGRATVRLTPGFDAAGAVRCDLLERPVAPAEPDVADLSFALRPFQLVTLRLARAALTAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JJD7</accession>
    <name>A0A2M9JJD7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_36335</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000024">
        <property type="protein sequence ID" value="PJN06962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN06962">
        <property type="protein sequence ID" value="PJN06962"/>
        <property type="gene ID" value="CG723_36335"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000835">
        <property type="entry name" value="HTH_MarR-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12802">
        <property type="entry name" value="MarR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00347">
        <property type="entry name" value="HTH_MARR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50995">
        <property type="entry name" value="HTH_MARR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH marR-type" evidence="1">
        <location>
            <begin position="20"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN06962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="156" mass="16435" checksum="6692C7D5FD1B2225" modified="2018-04-25" version="1">MHLSSRSSDAVEAQRIEGAARGLLRGLGQLTQALFRAGEFGITRSQAALLDALEPGPRRVTELAAATGMVQPRVTVMLQKLEEAGLVERQRCAADRRAVETSLSPAGRDLLEGGRRRMAAVLLAALDGGVEDSERAVGAARDAIAALVNAMESETS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JJQ1</accession>
    <name>A0A2M9JJQ1_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">acidPPc domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_35915</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000023">
        <property type="protein sequence ID" value="PJN07115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN07115">
        <property type="protein sequence ID" value="PJN07115"/>
        <property type="gene ID" value="CG723_35915"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036938">
        <property type="entry name" value="P_Acid_Pase_2/haloperoxi_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000326">
        <property type="entry name" value="P_Acid_Pase_2/haloperoxidase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01569">
        <property type="entry name" value="PAP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00014">
        <property type="entry name" value="acidPPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48317">
        <property type="entry name" value="SSF48317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="29"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="156"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="domain" description="acidPPc" evidence="2">
        <location>
            <begin position="57"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN07115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="213" mass="22301" checksum="B170550B48E2B142" modified="2018-04-25" version="1">MGIFDSGLYRDITGFAHGTPSWFQHLMEVFTELGLLAFALLFVVAWWRARRGDPRALTLAALAPPATGVAYVCSELVKSVVDEERPCRAVSGALNSLVACPPHGDWSFPSNHATIAAAAAVGLTLAWPAIGRLTVPVALLMAFSRVFVGVHYPHDVAVGLGVGALVSFVVVRLCVGGGVRVVVAMRGSGNGVVRWFAGPGVVGAYVAVGGHRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JJV2</accession>
    <name>A0A2M9JJV2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glyoxalase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_35875</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000023">
        <property type="protein sequence ID" value="PJN07144.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN07144">
        <property type="protein sequence ID" value="PJN07144"/>
        <property type="gene ID" value="CG723_35875"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004360">
        <property type="entry name" value="Glyas_Fos-R_dOase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00903">
        <property type="entry name" value="Glyoxalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VOC" evidence="1">
        <location>
            <begin position="4"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN07144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="148" mass="16494" checksum="F7BB8B7F87B2F696" modified="2018-04-25" version="1">MIKGLAISTVWVLDQDRAKEFYTEKLGLEVRTDMIMGEGGMRWLTVGAKDQPDVELTLMVPGVPAMDPESAEAVKKLVSKGILGAGVLVTDDIHGDYAKLKERGVQFLQEPQERPYGTEAIFRDDSGNWFSFTQRNEGLDLDKEWATS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JJW8</accession>
    <name>A0A2M9JJW8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CG723_34810</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000022">
        <property type="protein sequence ID" value="PJN07169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN07169">
        <property type="protein sequence ID" value="PJN07169"/>
        <property type="gene ID" value="CG723_34810"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PJN07169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="102" mass="11174" checksum="E3C7FEBAD13E1733" modified="2018-04-25" version="1">MLPPELPPLPALTRAECELLDRYLEVVDLLGRINPARSDHTYGGLRAAQALVGGATALRDALTLMHQRGETELHATTLARALRVLDGERRTQRVTVPPESVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JK77</accession>
    <name>A0A2M9JK77_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="14">CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CG723_35370</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">CB01635</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism; phospholipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="11">Phospholipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the CDP-alcohol phosphatidyltransferase class-I family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000022">
        <property type="protein sequence ID" value="PJN07270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN07270">
        <property type="protein sequence ID" value="PJN07270"/>
        <property type="gene ID" value="CG723_35370"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00077">
        <property type="reaction ID" value="UER00157"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00085"/>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008444">
        <property type="term" value="F:CDP-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1760">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000462">
        <property type="entry name" value="CDP-OH_P_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043130">
        <property type="entry name" value="CDP-OH_PTrfase_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004570">
        <property type="entry name" value="Phosphatidylglycerol_P_synth"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01066">
        <property type="entry name" value="CDP-OH_P_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000847">
        <property type="entry name" value="Phos_ph_gly_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00379">
        <property type="entry name" value="CDP_ALCOHOL_P_TRANSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="7" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="10" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12 14" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="104"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="136"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="167"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00025707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="PJN07270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="202" mass="22733" checksum="77A42F0E28D5C436" modified="2018-04-25" version="1">MEVQETRVQTDRVLTIPNILSMARLLGVPLFLWLILRPEFGGPKSDGWALLVLMLSGVSDYLDGKLARRWNQISNLGRLLDPAADRLYILSTLVGLTWREILPIWLTAVLLARELVLLVMVGILRRHGYPPPQVNFLGKAATFNLMYAFPLLLLSDGSGWINTLAAIFGWAFAGWGTTLYWWAGILYVVQVRRLVRADSKAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JK90</accession>
    <name>A0A2M9JK90_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">EamA family transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_35255</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000022">
        <property type="protein sequence ID" value="PJN07282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN07282">
        <property type="protein sequence ID" value="PJN07282"/>
        <property type="gene ID" value="CG723_35255"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000620">
        <property type="entry name" value="EamA_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00892">
        <property type="entry name" value="EamA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="34"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="73"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="99"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="130"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="158"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="190"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="219"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="252"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="277"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="2">
        <location>
            <begin position="6"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="2">
        <location>
            <begin position="157"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN07282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="301" mass="30275" checksum="E3FEC7CA99B76EEE" modified="2018-04-25" version="1">MLPVGRGLLYLVVAGVAWGTAGAAASLVFRASDLGPAALSFWRCVGGLALLLVARALRPRRNRPVAEPRLRRAVRIVVTGIALSVFQTAYFAGVQATGLAVATVVTLGAGPVLIALGARLIMGERLGGGGLVAVLGALAGLTVLVLGGGGAAVRPAGVGWALVSAAGYAVMTLLTRWFGRDGRSGDQLDTSVLTFAVAAVSLLPLGALEGLVPHTSQPLQVLGMLVYIASVPTALAYALYFSGAAVVRSATVSVIMLLEPVSAAVIAVALLGERLTAPTVAGTVLMLAAVTGLAVAEARAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JKN7</accession>
    <name>A0A2M9JKN7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CG723_33585</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000020">
        <property type="protein sequence ID" value="PJN07436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN07436">
        <property type="protein sequence ID" value="PJN07436"/>
        <property type="gene ID" value="CG723_33585"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016798">
        <property type="term" value="F:hydrolase activity, acting on glycosyl bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00041">
        <property type="entry name" value="fn3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="SSF49265"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="1 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fibronectin type-III" evidence="4">
        <location>
            <begin position="48"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="4">
        <location>
            <begin position="145"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="4">
        <location>
            <begin position="240"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="215"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PJN07436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="336" mass="34961" checksum="39E3DAEE07326494" modified="2018-04-25" version="1">MLPNGRPAVRRTPGRTPLAYAACAAALLFATSCGLLGDDTRQGPALTAPAGVTAQAGSATSVHVMWSRPEGDADIKGYTVYRGATKVKEVPGEQHMVDVVGLRPQSAYTFSVRAEDTDGTLGPLSAKVPVTTPAAVAEDRSAPTRPGALRGRADGGRAASLSWGASKDDKGVVSYDIYQGASKIHSVGGGETRALITGLRPGTAYAFTVKARDAADNTSPAGPALRLTTAKGSDEGPGSAPTDFRAGSRRADGAYYIDLSWTPPRTGGTVPAYRIYLDGRQATTLVWGDAPPKGTARNSFYVGKEAGVRHRVRIRAQLPDGTWGAYSTERSVITGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-09-29" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JKU2</accession>
    <name>A0A2M9JKU2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CG723_33965</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CB01635</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000020">
        <property type="protein sequence ID" value="PJN07495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN07495">
        <property type="protein sequence ID" value="PJN07495"/>
        <property type="gene ID" value="CG723_33965"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="31"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="66"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="97"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="123"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="166"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="191"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="281"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="314"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="345"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="369"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="415"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="438"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="32"/>
            <end position="462"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PJN07495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="481" mass="50889" checksum="C18B8821A190E8C5" modified="2018-04-25" version="1">MTPSGTVLIRSAADVSDLVNSGTARGRHAKMIVIIALGGIFLDAYDLSSLAYGLPDITRQFGLSSTMAGTVTASISVGSLLGALVGGWLVDRIGRYRVFMANMLFFVATALVCAVAQDVWTLIAARFVMGIGVGMDIPVAIAFLAEFSRLHGKGSKGSRTAAWSPAWYTATSGCYLVIMVLYFVLPDAQLGWLWRFTVGFGAVPALLVLLLRRRYMNESPTWAADQGDLEGAAKILRQSYGVDARVADDAPKTAPRPPRTGLGAYARLFAPPYRTRTIQSVAVGLAETFGYNAVAFGLPIIIATLMTQGPLTTIASSFALNLVFALTGGLLGIRWASTRGAWPMMTLGFAIQFVAITVLGLIGDPSGTAVVTAGILMLGAFMFAQGFGPGAHIMSYASLGFPTSMRGVSIGFNQAVLRLGSTLTLFFFPILSTGLGTHVYWVILAAPVLGLTALLAKRWEPIGFDADAEERSRSGLTASKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JKV2</accession>
    <name>A0A2M9JKV2_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Phenylacetate-coenzyme A ligase</fullName>
            <ecNumber evidence="1">6.2.1.30</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Phenylacetyl-CoA ligase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">paaF</name>
        <name evidence="4" type="ORF">CG723_34020</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CB01635</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>2-phenylacetate + ATP + CoA = AMP + diphosphate + phenylacetyl-CoA</text>
            <dbReference type="Rhea" id="RHEA:20956"/>
            <dbReference type="ChEBI" id="CHEBI:18401"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57390"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.2.1.30"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Aromatic compound metabolism; phenylacetate degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the phenylacetyl-CoA ligase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.2.1.30" evidence="1"/>
    <dbReference type="EMBL" id="NNBL01000020">
        <property type="protein sequence ID" value="PJN07504.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN07504">
        <property type="protein sequence ID" value="PJN07504"/>
        <property type="gene ID" value="CG723_34020"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00930"/>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047475">
        <property type="term" value="F:phenylacetate-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010124">
        <property type="term" value="P:phenylacetate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd05913">
        <property type="entry name" value="PaaK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028154">
        <property type="entry name" value="AMP-dep_Lig_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011880">
        <property type="entry name" value="PA_CoA_ligase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14535">
        <property type="entry name" value="AMP-binding_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006444">
        <property type="entry name" value="PaaK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02155">
        <property type="entry name" value="PA_CoA_ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0436">Ligase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-binding" evidence="2">
        <location>
            <begin position="82"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding_C_2" evidence="3">
        <location>
            <begin position="334"/>
            <end position="427"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRNR" id="PIRNR006444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF14535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PJN07504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="431" mass="47662" checksum="AC0B1F8019C5D73A" modified="2018-04-25" version="1">MTELLDAGELLGPEELHAQQLERLRATLRRVYEKVPFYRASFDKAGVHPEDCRSLADLARFPFTTKTDLRDNYPFGMFAVPETDVRRLHASSGTTGLPTVVGYTENDISMWADMVARSLRAAGARPGHKVHVAYGYGLFTGGLGAHYGAERLGCTVIPASGGMTARQVLLIQDFRPEVIMVTPSYMLTLLDEFERQGVDPRGTSLKVGVFGAEPWTEEMRREIEERFAIDAVDIYGLSEVMGPGVAQECVETKDGLHIWEDQFYPEVVDPITGEVLPDGEQGELVFTSLTKEAMPVIRYRTRDLTRLLPGTARPSFRRMEKVTGRSDDMVILRGVNLFPTQVEEIVLRTPGVAPHFQLRLTRAGRMDALTVRAEARADATAAERDAAARTIATGVKDGIGVSVTVEVVDPETLERSVGKIKRIVDLRGREG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JL76</accession>
    <name>A0A2M9JL76_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9 10">Chromosomal replication initiator protein DnaA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9 15" type="primary">dnaA</name>
        <name evidence="15" type="ORF">CG723_33205</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">CB01635</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9 10">Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9 11">Belongs to the DnaA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000019">
        <property type="protein sequence ID" value="PJN07625.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN07625">
        <property type="protein sequence ID" value="PJN07625"/>
        <property type="gene ID" value="CG723_33205"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003688">
        <property type="term" value="F:DNA replication origin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006275">
        <property type="term" value="P:regulation of DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06571">
        <property type="entry name" value="Bac_DnaA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1750.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00377">
        <property type="entry name" value="DnaA_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001957">
        <property type="entry name" value="Chromosome_initiator_DnaA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020591">
        <property type="entry name" value="Chromosome_initiator_DnaA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018312">
        <property type="entry name" value="Chromosome_initiator_DnaA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013317">
        <property type="entry name" value="DnaA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013159">
        <property type="entry name" value="DnaA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038454">
        <property type="entry name" value="DnaA_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010921">
        <property type="entry name" value="Trp_repressor/repl_initiator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30050:SF2">
        <property type="entry name" value="PTHR30050:SF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00308">
        <property type="entry name" value="Bac_DnaA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08299">
        <property type="entry name" value="Bac_DnaA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00051">
        <property type="entry name" value="DNAA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00760">
        <property type="entry name" value="Bac_DnaA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48295">
        <property type="entry name" value="SSF48295"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00362">
        <property type="entry name" value="DnaA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01008">
        <property type="entry name" value="DNAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 9 10" id="KW-0235">DNA replication</keyword>
    <keyword evidence="8 9 10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6 9 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA" evidence="13">
        <location>
            <begin position="371"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="domain" description="Bac_DnaA_C" evidence="14">
        <location>
            <begin position="585"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="89"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="215"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="236"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="279"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="379"/>
            <end position="386"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00377"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="PJN07625.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="678" mass="76172" checksum="9B4DD87211B2EEB2" modified="2018-04-25" version="1">MADVPADLAAVWPRVLEQLLGEGRGQGVETKDEHWIRRCQPLALVADTALLAVPNEFAKGVLEGRLAPVVAETLSRECGRPIRIAITVDDSVGEQPVPSAPPVPQHRYEEPELPPAQNQAQNQAHEPYDPYGRRSDDHAQGPRGDQSQGARADQLPTARPAYPDYQRPEPGAWPRSQDEYSWQQPRLGFPERDPYANPPQQPQHDYRQQERSPYEQQNERSPYEQQQERSPYEQQERSPYDQQPDRTGYDQQADRNGYDQQVERSGYEQQSERSSYEQQMSDRQGRHGRHERRDLNDGPMGGRPGQDGRTGRGVPSGAPGPLAAQPAPATGPGEPTARLNPKYLFDTFVIGASNRFAHAAAVAVAEAPAKAYNPLFIYGESGLGKTHLLHAIGHYARSLYPGTRVRYVSSEEFTNEFINSIRDGKGDSFRKRYREMDILLVDDIQFLADKESTQEEFFHTFNTLHNANKQIVLSSDRPPKQLVTLEDRLRNRFEWGLITDVQPPELETRIAILRKKAVQEQLNAPPEVLEFIASRISRNIRELEGALIRVTAFASLNRQPVDLGLTEIVLKDLIPGGEDSAPEITATAIMAATADYFGLTVEDLCGSSRSRVLVTARQIAMYLCRELTDLSLPKIGAQFGGRDHTTVMHADRKIRALMAERRSIYNQVTELTNRIKNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JLJ6</accession>
    <name>A0A2M9JLJ6_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">GHL10 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CG723_32290</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000018">
        <property type="protein sequence ID" value="PJN07751.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN07751">
        <property type="protein sequence ID" value="PJN07751"/>
        <property type="gene ID" value="CG723_32290"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003790">
        <property type="entry name" value="GHL10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02638">
        <property type="entry name" value="GHL10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014896379" description="GHL10 domain-containing protein" evidence="2">
        <location>
            <begin position="28"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="domain" description="GHL10" evidence="3">
        <location>
            <begin position="39"/>
            <end position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PJN07751.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="402" mass="45034" checksum="1A2D6A64126E17E2" modified="2018-04-25" version="1">MRHLSRRGFAVAAAAALTGLAAGDAVASGSGHAPVARDMRGMWLATVANRDWPSKPGLSAAQQRTELIAHLDTAVGRRLNAVVFQVRPTADALWPSPYEPWSGVLTGVQGKDPGWDPLGTAVAEAHRRGLELHAWFNPYRIANHTDLSRLVPTHPARRHPDWVVPYGGKLYYNPGLPEVRKFVQDAMLDAVRRYDIEAVHWDDYFYPYPVAGQVFDDDAAYAAHGGNFPDRASWRRDNTDRLVREMAASVKRIRPRTQFGISPFGVWRNAATDPLGSDTRAGVQTYDDLHADTRKWVREHWIDYICPQIYWNIGFAAADYAKLVPWWSDVARGTGVRLYAGEALYKAGDPAQPAEWQDPAELSRHLTFAERYPQVNGHVFFSAKEVRADRIGAMARVVEDHY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JLL7</accession>
    <name>A0A2M9JLL7_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Translation initiation factor IF-3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">infC</name>
        <name evidence="8" type="ORF">CG723_32350</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CB01635</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the IF-3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000018">
        <property type="protein sequence ID" value="PJN07763.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN07763">
        <property type="protein sequence ID" value="PJN07763"/>
        <property type="gene ID" value="CG723_32350"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00080">
        <property type="entry name" value="IF_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036788">
        <property type="entry name" value="T_IF-3_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036787">
        <property type="entry name" value="T_IF-3_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001288">
        <property type="entry name" value="Translation_initiation_fac_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019815">
        <property type="entry name" value="Translation_initiation_fac_3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019814">
        <property type="entry name" value="Translation_initiation_fac_3_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10938">
        <property type="entry name" value="PTHR10938"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00707">
        <property type="entry name" value="IF3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05198">
        <property type="entry name" value="IF3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54364">
        <property type="entry name" value="SSF54364"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55200">
        <property type="entry name" value="SSF55200"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00168">
        <property type="entry name" value="infC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 4 8" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3 4" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="IF3_N" evidence="7">
        <location>
            <begin position="15"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="domain" description="IF3_C" evidence="6">
        <location>
            <begin position="92"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="178"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="178"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="216"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF05198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PJN07763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="241" mass="26793" checksum="B5914BC0A60DE6E8" modified="2018-04-25" version="1">MWCYRGGSISAEPRINDRIRVPEVRLVGPSGEQVGIVPLAKALELAQEYDLDLVEVAATARPPVCKLMDYGKFKYESAMKAREARKNQAHTVIKEMKLRPKIDPHDYDTKKGHVVRFLKAGDKVKITIMFRGREQSRPELGFRLLQRLASDVEDLGFIESNPKQDGRNMIMVLGPHKKKTEAMAEAREAQEARKAEQKALPTHGRTQRASDDAAESESEAPAEATDEAPAEEATAEASAEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JM34</accession>
    <name>A0A2M9JM34_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_31235</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000017">
        <property type="protein sequence ID" value="PJN07946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN07946">
        <property type="protein sequence ID" value="PJN07946"/>
        <property type="gene ID" value="CG723_31235"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="54"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN07946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="73" mass="8101" checksum="ECE5D7A21A133090" modified="2018-04-25" version="1">MPAPTQMLKGRTVYRVVWKLNTDVLVGYCWCGTAHEDTDPIALWEWLLAHPDTHGGGRTDSAVPDPEPELVDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JM77</accession>
    <name>A0A2M9JM77_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_30190</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000016">
        <property type="protein sequence ID" value="PJN07973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN07973">
        <property type="protein sequence ID" value="PJN07973"/>
        <property type="gene ID" value="CG723_30190"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="48"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="89"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="138"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="179"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="210"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="261"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN07973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="286" mass="29405" checksum="ECB3D1B3CED25933" modified="2018-04-25" version="1">MSTLTATPEIPETPGTDQATQGGPVYRVTGRRVLSSEWAKLWSVRSTWITLGLGLLFLVAFGVIAASHYKSEIGSGRPMDRDFGSATAVSLSLFGTNFAQLALGVLGVLVTAGEYSTGMIRSTLAAVPRRLPVLWSKAVVYGLVALVIATFGAFVAFLVGSQIVSGTPAAMGLGHAGVVRSLLGAGLYLGLVGVIGTALGALMRSVAGGISVLVATLMLVPGLISLLPSSWQGDIDPYLPSNAGEATFALTHDSTTLSPTAGLLVFLGWTALALAGAAYRLLRSDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JMP7</accession>
    <name>A0A2M9JMP7_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ATPase_AAA_core domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_29455</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000015">
        <property type="protein sequence ID" value="PJN08134.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08134">
        <property type="protein sequence ID" value="PJN08134"/>
        <property type="gene ID" value="CG723_29455"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATPase_AAA_core" evidence="1">
        <location>
            <begin position="50"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN08134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="490" mass="54165" checksum="E7488A4CB074238E" modified="2018-04-25" version="1">MTPLTADEYRTLIDRALEGAVDANTTEPDLRRLFTPSSHRLALAPDVTVVKGARGTGKTYWAKALTDPRLREIAAASYLMPRLRRVEIATGFAADRTADAAYPTKRVIARLMRDDEFDPVDFWFMIVLMALQVPGIAAISDWSGRMGWVRDNPEALDDALQEADSAAHDAGTTRVLLFDALDHLHRDRTQADRLVSGLLEVALELRLTTSALRAKIFIRPDMYDSAPKKFADASKLTANTAELTWLRENLYGLFFHQLGNYDGPGAAEFRAATGSWRDEGEGRFIAPTDVIADQTRQEAVFGDIAGPYMGTDRRKGLTYTWVPNHLQDGREEVSPRTWLYSLREAAVVSAERYAGHEYALHYDAIRASLHGASRIRVEELTEDIAWAVAAVGKLEGGEVPMEPSVVIAHWNQGGLSTALRELAEDSGQDGQEDDGGSGPRKPDDLFAVLEELIDIGVLTRRLTTGAIDLPDVYRLNFNIGRRGGVSRKKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JMQ5</accession>
    <name>A0A2M9JMQ5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Fibrillarin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CG723_29585</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000015">
        <property type="protein sequence ID" value="PJN08160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08160">
        <property type="protein sequence ID" value="PJN08160"/>
        <property type="gene ID" value="CG723_29585"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007621">
        <property type="entry name" value="TPM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04536">
        <property type="entry name" value="TPM_phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014838479" evidence="5">
        <location>
            <begin position="38"/>
            <end position="699"/>
        </location>
    </feature>
    <feature type="domain" description="TPM_phosphatase" evidence="6">
        <location>
            <begin position="50"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="170"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="218"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="679"/>
            <end position="699"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PJN08160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="699" mass="72294" checksum="A0A3552A6C8A50DF" modified="2018-04-25" version="1">MTPPPSRPRPVRIAARSAVAAVLALCWALLPATASRADDPITLSRAGQITDKVDALRDREPDVASALDSLDSKRNTQLFVVYVRDFSGRSAQDWADDTASKNGLGLNDVLLAVATHDRQYAYSVDQDSQLTDAQLKDVAQTAIEPALRRNDWAGAAIGAAGGISATLGGSPVPTPAITPGPADPGGSDTDPSAADLALPLIVVGGAGAVAAFAYTRRKRRTSTRTTPGGGWGGRGTGPQVTPLPELDKQARRMLVESDDSIRTSTEELGFATAQFGEEAVKPFTEAVAYAQSELTAAFRLRQQLDDAYPEDDATKRQMLDEIVNRCTEAGRRLDAEAADFDRLRALERTAPEALAHAELASRDLATRTTTAEETLTALGARYAPSALLPVAGHIEQAKDRLLFATTNLEQARSGVDAGDNGRAAVFLRAAESAVDQAGTFVDAIDRLGHELAEAAEKLPAALTESDSDLADAHGLLEGTTEGASTADLRGRIARVQTVTAGVRKEMAAGPYDPIDALRRVEEADSALDASLDEARERESGTARARSLLDQAELTARSSVGAASDFITTHRGAVGSEARTRLAEAQRHLEYVRTTAEADPTAALAGAQRADALARQAQQLAEHDVRSFGNPYGGGGGGGRSGGGMGGAVLGGIILGELLGGGRGGGFGGGGGFGGGFGGGGPGSFGGGGTRGRRGGGGRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JMZ3</accession>
    <name>A0A2M9JMZ3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CG723_30040</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000015">
        <property type="protein sequence ID" value="PJN08243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08243">
        <property type="protein sequence ID" value="PJN08243"/>
        <property type="gene ID" value="CG723_30040"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PJN08243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="69" mass="7582" checksum="333C066E383E99C3" modified="2018-04-25" version="1">MTSLPDGDSAQRPEPEPGTIVCALCGTTAQGAPPTWTYSVENGTGRHYCDRCARENLRAIEGRLDSEWW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JNE8</accession>
    <name>A0A2M9JNE8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Fe-S oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CG723_28830</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000014">
        <property type="protein sequence ID" value="PJN08391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08391">
        <property type="protein sequence ID" value="PJN08391"/>
        <property type="gene ID" value="CG723_28830"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1060.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004017">
        <property type="entry name" value="Cys_rich_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009051">
        <property type="entry name" value="Helical_ferredxn"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02754">
        <property type="entry name" value="CCG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13183">
        <property type="entry name" value="Fer4_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="71"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="112"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="152"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="209"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="6">
        <location>
            <begin position="293"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="6">
        <location>
            <begin position="381"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="738"/>
            <end position="760"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PJN08391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="760" mass="83959" checksum="9BE66819FF842AD0" modified="2018-04-25" version="1">MQLAAIIVSLVLIVVGVALFVRAIAQIYRFMRLGQNVPAGTRTDEPVQRTVTVAKEFLGHTRMNRWGIVGVAHWFVAVGFFSLLLTIVNAIGQLFQADWLLPIIGEWAPYNVFVEFLGTMTALGILTLIVIRQLNRPDRPGRKSRFAGSNTGQAYFVEAVILIVGICIFTLHALEGAQHHVDSYEASFFVSYPVVSWFRGMDVSTLQNLTYFFAGLKIATSFIWMITVALKTDMGVAWHRFLAFPNIWFKREADGGTALGALQPMTSGGKEIDFEDPGEDDVFGVSQVEQFSWKGLLDFSTCTECGRCQSQCPAWNTGKPLSPKLLIMSLRDHAHAKAPYLLAGGGKSMEGEEKATEEQLKDVPAAALAEAERPLIGTLEENGVIDPDVLWSCTTCGACVEQCPVDIEHIDHIVDMRRYQVMIESAFPSEAGTMLKNLEKKGNPWGLAKKQRLEWLKELDFEVPVVGKDIEDLTEVEYLYWVGCAGSLEDRAKKTTKAFAELLHMAGVKFAIMGGDEKCTGDSARRLGNEPLFQQLGQENVMALNMAFGEELDDDGKVVAESAKPKSAKKIVATCPHCLNTIGNEYPQLGGDYEVIHHTQLLQHLIDEGKLVPVTPVEGLITYHDPCYLGRHNKVYTPPRQIMDAVPGLRQQEMHRHKERGFCCGAGGARMWMEERIGKRINNERVDEALSLNPDIVSTACPFCLVMLTDSVNGKKNDGQAKESVTVVDVAQLLLDSVKTPVDPAGSEETEDAPEPEPVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JP09</accession>
    <name>A0A2M9JP09_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF3291 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_28025</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000013">
        <property type="protein sequence ID" value="PJN08608.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08608">
        <property type="protein sequence ID" value="PJN08608"/>
        <property type="gene ID" value="CG723_28025"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021708">
        <property type="entry name" value="DUF3291"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11695">
        <property type="entry name" value="DUF3291"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF3291" evidence="1">
        <location>
            <begin position="4"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF11695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN08608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="185" mass="20792" checksum="CD63366D8E6EB473" modified="2018-04-25" version="1">MPHLALYTFGVLKSPLVDPAPLTREFYDIGEAVYRKISQHPGYLAHAEAADGDRGALFEADWGAWGEFAVPTWYGKGHTLETTALAATLSLWTDLRPALDAIYTGLHREALNRRYDWFERTGHPNYVFWWVSDGVTPTWQDGVSRLEHLHNHGSAPHAFTFHHSFAPDGTPTRIKGIGPKSDQVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JP34</accession>
    <name>A0A2M9JP34_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Aminotransferase</fullName>
            <ecNumber evidence="1">2.6.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_27960</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.-" evidence="1"/>
    <dbReference type="EMBL" id="NNBL01000013">
        <property type="protein sequence ID" value="PJN08626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08626">
        <property type="protein sequence ID" value="PJN08626"/>
        <property type="gene ID" value="CG723_27960"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044249">
        <property type="term" value="P:cellular biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004838">
        <property type="entry name" value="NHTrfase_class1_PyrdxlP-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00105">
        <property type="entry name" value="AA_TRANSFER_CLASS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotran_1_2" evidence="2">
        <location>
            <begin position="30"/>
            <end position="368"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN08626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="417" mass="43134" checksum="117A379F4A300A66" modified="2018-04-25" version="1">MTMHSATLAINETLQARKAAGEKVLHLGFGEAGLPVPEPVAQALAEAARRNGYGPVVGSVEAREAAAGWFSRRGLATDPDQILFAPGSKSLLFALLAALPGDLVLPRPAWVSYAAQASIVGKRTLPVPIPAGAGGIPDPELLDEALVAARAAGHSPGVLLLTVPDNPTGTVAPADQVRAVCAIAERHGLAVVSDEIYAELVHDGSRAPSAAAHLPERTVITSGLSKSMALGGWRIGFARVPQGPWGRALTADLVGVASEIWSALAAPMQAAAAYVLDDPDEVTAHIDTARRLHGTVARAVHAEFVKAGADCRAPRAGFYLYPDFEPLRAELAARSVSTGSELAGVLLEGHGVGVLAGSAFGDEERGLRARVATSLLYGESTDQRWAALRSADPLALPWIADSLAHLRGALADVTGRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JPI5</accession>
    <name>A0A2M9JPI5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Sensor histidine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CG723_27345</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000012">
        <property type="protein sequence ID" value="PJN08793.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08793">
        <property type="protein sequence ID" value="PJN08793"/>
        <property type="gene ID" value="CG723_27345"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011712">
        <property type="entry name" value="Sig_transdc_His_kin_sub3_dim/P"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07730">
        <property type="entry name" value="HisKA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="48"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="74"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="109"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="144"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="domain" description="HisKA_3" evidence="3">
        <location>
            <begin position="207"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="168"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PJN08793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="434" mass="45633" checksum="AE021910EF8D1D5F" modified="2018-04-25" version="1">MTTTGEMHRTAGGPWWWERRRSAVLDVGLAVASAVECGVEGVGFARDAGVPAAVGVVFGVLAGSMLVLRRRWPIAVVLIGVAVTPARMGVLLSVVGLYTLAASEMPRRIIGALAGMSFVGTLIVSVVRAQQDVGHGNLVRVGDWFVPFVAITTSLGVTAPPLLLGLYVGARRRLMESLRERADSLERELQLLAERAEERAEWARGEERTRIAREMHDVVAHRVSLMVVHAAALQAVARKDPEKAVKNAALVGDMGRQALTELREMLGVMRSGGGGREPGAGVPLAAVGVAAAAAASRAVDEEDGPCLGDLDELVGQSRAAGMVVELLVEGDSRSYVAVVEQTAYRVVQEALTNVHKHAAGAKTYVRLAHRVSEFAMQVENEPPPDVDSAGGVRLPSGGNGLVGMRERVTGLGGVFVCGPTDAGGYRVSAVLPAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JPV7</accession>
    <name>A0A2M9JPV7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Two-component sensor histidine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CG723_25615</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000011">
        <property type="protein sequence ID" value="PJN08875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08875">
        <property type="protein sequence ID" value="PJN08875"/>
        <property type="gene ID" value="CG723_25615"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011712">
        <property type="entry name" value="Sig_transdc_His_kin_sub3_dim/P"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07730">
        <property type="entry name" value="HisKA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="37"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="76"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="107"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="132"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="domain" description="HisKA_3" evidence="3">
        <location>
            <begin position="184"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="366"/>
            <end position="395"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PJN08875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="395" mass="41557" checksum="A7DA49D875700D12" modified="2018-04-25" version="1">MPLPRPHRDDVRIAAIGLLGGLLLWALGLTNSQGWRVLGGGWLLVPLCAMAGLELLRRTAPQTALVLGTFVLIADQFTPGSLATTLMFTDLVYAAVLYGTPAAARRIPVTTALITIAVTLGFLAWFRKPEALLIGVVSGLVSFAPAATGVLVRNHREAAESARLRAEQTALLAEMDRTQAVVAERARMARELHDMVANHLSAIAIHSTAALSLDEPRTTQQALTVIRENSVEGLAEMRRLIGILRDDSGDSQGEPVAAPTLDGLGALIEQSRTNGLDVTLAVGDGVGGLPAPIELAAYRIVQESLTNALKHASHGPVTVAVHRTGGALTVRVTSPYGEVDGPRAPGSGAGLIGMRERTALLRGTFEAGPESGPGRKIWQVRAELPVDPADEGVSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JPW8</accession>
    <name>A0A2M9JPW8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CG723_25860</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000011">
        <property type="protein sequence ID" value="PJN08914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08914">
        <property type="protein sequence ID" value="PJN08914"/>
        <property type="gene ID" value="CG723_25860"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014909413" evidence="3">
        <location>
            <begin position="33"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="58"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="36"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PJN08914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="86" mass="8423" checksum="7B25E30E30545F55" modified="2018-04-25" version="1">MSTTRRACLLARGTFVAAVLGGALLVPTAAFAHAQPDRAAAPAPASEPGHGTPDSNPLFLAAGGGMAAAGAGGLAFSMYRRGRTDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JPZ9</accession>
    <name>A0A2M9JPZ9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ectoine/hydroxyectoine ABC transporter ATP-binding protein EhuA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CG723_26030</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000011">
        <property type="protein sequence ID" value="PJN08944.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08944">
        <property type="protein sequence ID" value="PJN08944"/>
        <property type="gene ID" value="CG723_26030"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015424">
        <property type="term" value="F:ABC-type amino acid transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030679">
        <property type="entry name" value="ABC_ATPase_HisP-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039085">
        <property type="entry name" value="ABC_ATPase_HisP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="7"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="39"/>
            <end position="46"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PJN08944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="255" mass="28170" checksum="A7913EBA22065F5A" modified="2018-04-25" version="1">MTTNPMVKSEGVHKSFGNVEVLKGIDLEVKEGEVFCLIGPSGSGKSTFLRCINHLEKINAGRLYVDGELVGYRQKGDKLYELKDSEVALKRRDIGMVFQRFNLFPHLTALENVMEAPVQVKRQSRSQARQRAGELLERVGLADKAGNYPSQLSGGQQQRVAIARALAMDPKLMLFDEPTSALDPELVGDVLDVMRDLAESGMTMIVVTHEMGFAREVGDSLVFMDGGVVVESGHPRDVLTNPQHERTQSFLSKVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JQ95</accession>
    <name>A0A2M9JQ95_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Anion permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CG723_24265</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CB01635</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000010">
        <property type="protein sequence ID" value="PJN09049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN09049">
        <property type="protein sequence ID" value="PJN09049"/>
        <property type="gene ID" value="CG723_24265"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005315">
        <property type="term" value="F:inorganic phosphate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006817">
        <property type="term" value="P:phosphate ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001204">
        <property type="entry name" value="Phos_transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11101">
        <property type="entry name" value="PTHR11101"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01384">
        <property type="entry name" value="PHO4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="42"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="81"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="108"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="133"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="216"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="305"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PJN09049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="332" mass="34607" checksum="EF8FCFAC03BECDCD" modified="2018-04-25" version="1">MDTFALIVTIGVALGFTYTNGFHDSANAIATSVSTRALTPRAALAMAAVMNLAGAFMGSGVAKTVSEGIIATPEGGKGMGILFAALVGAIIWNLVTWYFGLPSSSSHALFGGMVGAALAGGTAVYWSGVLDKIVIPMLTSPVIGLIVGYLVMCAILWLFRRSNPHKAKRGFRIAQTVSAAGMALGHGLQDAQKTMGIVVMALVISGHETYSDPIPVWVKLVCALMLSLGTYAGGWRIMRTLGRKIIELDPPQGFAAETTGASIMFGSAFLFHAPISTTHVITSAIMGVGATKRVKAVRWGVAKNIVLGWFITMPAAALVAAGSFWIVNLAFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JQB6</accession>
    <name>A0A2M9JQB6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Sugar transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_26200</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000011">
        <property type="protein sequence ID" value="PJN08977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08977">
        <property type="protein sequence ID" value="PJN08977"/>
        <property type="gene ID" value="CG723_26200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008643">
        <property type="term" value="P:carbohydrate transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006059">
        <property type="entry name" value="SBP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01547">
        <property type="entry name" value="SBP_bac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014702587" evidence="1">
        <location>
            <begin position="25"/>
            <end position="426"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN08977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="426" mass="45311" checksum="560B90A79A7EFA45" modified="2018-04-25" version="1">MKRRLIAAIGVAGMLVSIAACGSGDDGSTDKKAGADGYKGQTLTVWAMDGSTPDTWQKDVTAAFEKKTGAKLKIEIQQWNGIQQKLTTALSEENPPDVFEVGNTQTPAYAKTGGLADLSDLKSSLGADWAESMNKSAVSDGKQYAAPWFVVNRVVIYNKKIWADASIKDLPKTRDEFYKDLETIGKKTDAEPIYLPGQNWYHFVGLTIGEGAELVKKDGDKYVSNLADPKVGAAMETYKKFQALSKAPKDKDEATPQQAEVFAKGKTGSFIGMGWESALAIKANPKIEKEIGYFTVPGATADKPEGVFLGGSNLAVAAGSKKQDLAKEFLKIALSDQFEGQLAKEGGVIPNKEALQSNLKGNAAAEAAAPAAAGGGTTPLIPEWAPVENAPNPVKTYMTAVLKGKSPAAAAKQVEAEFNKRLSQKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-09-29" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JQC8</accession>
    <name>A0A2M9JQC8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Metal-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_24295</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000010">
        <property type="protein sequence ID" value="PJN09055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN09055">
        <property type="protein sequence ID" value="PJN09055"/>
        <property type="gene ID" value="CG723_24295"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.40.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007899">
        <property type="entry name" value="CHAD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038186">
        <property type="entry name" value="CHAD_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05235">
        <property type="entry name" value="CHAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00880">
        <property type="entry name" value="CHAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51708">
        <property type="entry name" value="CHAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CHAD" evidence="1">
        <location>
            <begin position="12"/>
            <end position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN09055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="353" mass="37087" checksum="4CA1BAC1BEE55F0B" modified="2018-04-25" version="1">MAQQHLETTGAEGSAGEVVAAHLREQATEFLRSLRQHRESGGAAPGGTAEEAADAARALRRSARRISGTLHTFRPLLDPEWSDALRPELAWLSGTLAQEHAYAGRLERLLSALHRLSGAHAVPAQAPAALAGRVSTAQLPRNENTASGNLTVGAAKAGALLERQLTLARTRAHSTALQALGSSRFHAVADNVAVLASEVPLRAAPADLDALAATAESRLAEAVAALPLHRAGHPYNAEALVQGLTADTAPPSQDAPWHHVRLLLRLHRYAQEVVPCGPGGGPTDAETEAAAALDRHRDAAEAAAAAAHAARTPRIAPATAYALGVLHADQRHEVEAARFAFQRAWLKETVHTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JQE9</accession>
    <name>A0A2M9JQE9_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5">2,3-bisphosphoglycerate-dependent phosphoglycerate mutase</fullName>
            <shortName evidence="4">BPG-dependent PGAM</shortName>
            <shortName evidence="4">PGAM</shortName>
            <shortName evidence="4">Phosphoglyceromutase</shortName>
            <shortName evidence="4">dPGM</shortName>
            <ecNumber evidence="4 5">5.4.2.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">gpmA</name>
        <name evidence="6" type="ORF">CG723_24605</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CB01635</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4 5">Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4 5">
            <text>(2R)-2-phosphoglycerate = (2R)-3-phosphoglycerate</text>
            <dbReference type="Rhea" id="RHEA:15901"/>
            <dbReference type="ChEBI" id="CHEBI:58272"/>
            <dbReference type="ChEBI" id="CHEBI:58289"/>
            <dbReference type="EC" id="5.4.2.11"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4 5">Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 3/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the phosphoglycerate mutase family. BPG-dependent PGAM subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.4.2.11" evidence="4 5"/>
    <dbReference type="EMBL" id="NNBL01000010">
        <property type="protein sequence ID" value="PJN09101.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN09101">
        <property type="protein sequence ID" value="PJN09101"/>
        <property type="gene ID" value="CG723_24605"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00186"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046538">
        <property type="term" value="F:2,3-bisphosphoglycerate-dependent phosphoglycerate mutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07067">
        <property type="entry name" value="HP_PGM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01039">
        <property type="entry name" value="PGAM_GpmA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001345">
        <property type="entry name" value="PG/BPGM_mutase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005952">
        <property type="entry name" value="Phosphogly_mut1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11931">
        <property type="entry name" value="PTHR11931"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00300">
        <property type="entry name" value="His_Phos_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00855">
        <property type="entry name" value="PGAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="SSF53254"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01258">
        <property type="entry name" value="pgm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00175">
        <property type="entry name" value="PG_MUTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0312">Gluconeogenesis</keyword>
    <keyword evidence="2 4" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="3 4" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="4">
        <location>
            <begin position="12"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="4">
        <location>
            <begin position="25"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="4">
        <location>
            <begin position="91"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="4">
        <location>
            <begin position="118"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="4">
        <location>
            <begin position="187"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="active site" description="Tele-phosphohistidine intermediate" evidence="4">
        <location>
            <position position="13"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="4">
        <location>
            <position position="91"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="64"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="102"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="4">
        <location>
            <position position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PJN09101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="253" mass="28199" checksum="024E7400857A11D3" modified="2018-04-25" version="1">MADAPYKLILLRHGESEWNAKNLFTGWVDVNLNEKGEKEAVRGGELLKDAGLLPDVVHTSLQKRAIRTAQLSLEAADRHWIPVHRSWRLNERHYGALQGKDKAQTLAEFGEEQFMLWRRSYDTPPPPLARDAEYSQFNDARYATLPPELRPQTECLKDVVVRMLPYWFDAIVPDLLDGKTVLVAAHGNSLRALVKHLDGISDADIAGLNIPTGIPLSYELDADFKPLTPGGTYLDPDAAAAAIEAVKNQGKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-09-29" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JQF0</accession>
    <name>A0A2M9JQF0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CG723_24600</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CB01635</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000010">
        <property type="protein sequence ID" value="PJN09100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN09100">
        <property type="protein sequence ID" value="PJN09100"/>
        <property type="gene ID" value="CG723_24600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="21"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="51"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="86"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="110"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="149"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="173"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="224"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="259"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="289"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="350"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="377"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="20"/>
            <end position="398"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PJN09100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="424" mass="44564" checksum="9EC9619503C4C0C5" modified="2018-04-25" version="1">MSVTALRRAAHESVSGLPRQFWWLWTSTLINRLGGFVLTFMALYLTTERHFSASFAGLVAALVGLGGMIASVLGGVLADRIGRRPTLLAAQLATAVTVAVLAFVRDPVGIAVTGFLLGVASNASRPAVQAMMADLVAPKDRVRAFSLNYWAINLGFAVSSVYAGFLVAASYTAGFLLEAAMTLACAVLVFVKVPESRPERAEPKPDAAPVADVTMLTVLRDGRYMLMVGLSFLISVVFTQSSSGLPIVMGQAGLSSSDVGLVAAVNGIVIVALQIPLTRFIEKRDAGRLLTVSSLLIGYGFALTAFAGSMAAYALIVVVWTLGEMVNAPTQSGLVARLAPTHGRGRYQGMYSMSWSVAALVAPLASGVTIDRFGAEWLWAGCAAIGTVAAAGYWILMRGLPTEEHPVAPVPSPEKTVTEPELTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JQH4</accession>
    <name>A0A2M9JQH4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">23S rRNA (Guanosine(2251)-2'-O)-methyltransferase RlmB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_24730</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000010">
        <property type="protein sequence ID" value="PJN09123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN09123">
        <property type="protein sequence ID" value="PJN09123"/>
        <property type="gene ID" value="CG723_24730"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008173">
        <property type="term" value="F:RNA methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1280.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029028">
        <property type="entry name" value="Alpha/beta_knot_MTases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029064">
        <property type="entry name" value="L30e-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004441">
        <property type="entry name" value="rRNA_MeTrfase_TrmH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001537">
        <property type="entry name" value="SpoU_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013123">
        <property type="entry name" value="SpoU_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029026">
        <property type="entry name" value="tRNA_m1G_MTases_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46429">
        <property type="entry name" value="PTHR46429"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00588">
        <property type="entry name" value="SpoU_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08032">
        <property type="entry name" value="SpoU_sub_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00967">
        <property type="entry name" value="SpoU_sub_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55315">
        <property type="entry name" value="SSF55315"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75217">
        <property type="entry name" value="SSF75217"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00186">
        <property type="entry name" value="rRNA_methyl_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SpoU_sub_bind" evidence="2">
        <location>
            <begin position="72"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN09123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="314" mass="32814" checksum="A1BCC1093928E7FC" modified="2018-04-25" version="1">MAANNRRMSGKKGAQVGSGGQRRRGLEGKGPTPPAEARKGHKKNRIAGAKAKQATRRPATLKSRGGKGTSEMVVGRNSVVEALREGVPASMLYVQQFIDNDERVREALQLAGERGGIHLMEAPRPELDRMTNGLNHQGLVLQVPPYEYAHPEDLAAAAYDQGQDPLIVALDGVTDPRNLGAVVRSVSAFGGHGVVVPERRAAGMTAGAWKTSAGAAARTPVARATNLTRALEGYKKAGIAIVGLAADGEHTVGDLEALGGPVVIVVGSEGKGLSRLVGETCDYRVRIPMPGGTESLNAGVAAGVVLYEASRRRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JQX1</accession>
    <name>A0A2M9JQX1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">TetR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CG723_23240</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000009">
        <property type="protein sequence ID" value="PJN09270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN09270">
        <property type="protein sequence ID" value="PJN09270"/>
        <property type="gene ID" value="CG723_23240"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041490">
        <property type="entry name" value="KstR2_TetR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17932">
        <property type="entry name" value="TetR_C_24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="6">
        <location>
            <begin position="28"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="4">
        <location>
            <begin position="51"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PJN09270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="218" mass="24212" checksum="96F5D6526FDD446E" modified="2018-04-25" version="1">MRAAQGATQDGSYERPHRPAQPGGASPADRRSAIRQAALQLFAAQGYRSTTMADIGAAVGIRGPSLYKHVESKQELLVEIMIGTMEQLIADNRAAVAGVDDVHEQLRRSVEAHIRYHARHRLEAFVGNREIGSLEQPDQDRVLSRRSAYERRFRELIERGAAEGVFHVQSARIASYSILDMGIGVSSWFHEVGEFTVDQLAYQYGDIALRIVGVAEQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JR09</accession>
    <name>A0A2M9JR09_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">GDSL family lipase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_23525</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000009">
        <property type="protein sequence ID" value="PJN09319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN09319">
        <property type="protein sequence ID" value="PJN09319"/>
        <property type="gene ID" value="CG723_23525"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01823">
        <property type="entry name" value="SEST_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037460">
        <property type="entry name" value="SEST-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013830">
        <property type="entry name" value="SGNH_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37981">
        <property type="entry name" value="PTHR37981"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13472">
        <property type="entry name" value="Lipase_GDSL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SGNH_hydro" evidence="2">
        <location>
            <begin position="80"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN09319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="327" mass="34214" checksum="3F826725D9C1B3D8" modified="2018-04-25" version="1">MPPLPLTRRGTAVPLHRSHHSSLKSSSAGGVRRPLLRAAVSVGTAGLVGLALVQPAAANSGDQVRPSHANRAAAPVRYVALGDSYSSGLGIPDEVEPNCGRSDSNYPSLVAEALHAASVTDVTCAGADTSHMAGPQESAPPQLDALRPDTTLVTLGIGGNDLGLQEVGTRCVLVAYLDPNGSPCKTSYTLLGTDEIRSRINTTAPKIDAILQEIHARSPQAKVLLVGYPAIMPDDGSACRDAIPFAAGDFAWFRDKEKELNSMLSQQTSVYGATFVNTYSPSVGHDACKAEGVRWIEPKETPEAAGFHPNAAGHRSMAAEVLARINP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-09-29" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JR54</accession>
    <name>A0A2M9JR54_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Integrase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_23780</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000009">
        <property type="protein sequence ID" value="PJN09355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN09355">
        <property type="protein sequence ID" value="PJN09355"/>
        <property type="gene ID" value="CG723_23780"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13683">
        <property type="entry name" value="rve_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="2">
        <location>
            <begin position="1"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="39"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN09355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="133" mass="14735" checksum="7D07CC21881DE943" modified="2018-04-25" version="1">MDTGMNITGIKFLIRDRDGQFTDAFDAVLADLGLRVLKSPPQAPKANTHSERFNGTPAPRAPRPDTHPQRTALRPTLTRHLEHYNGHRPHRALNQLCPSQAEAGPPRPIDLAEHRVHRAAVLGGLINEYQTSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JR85</accession>
    <name>A0A2M9JR85_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CG723_23900</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000009">
        <property type="protein sequence ID" value="PJN09373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN09373">
        <property type="protein sequence ID" value="PJN09373"/>
        <property type="gene ID" value="CG723_23900"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015833">
        <property type="term" value="P:peptide transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013563">
        <property type="entry name" value="Oligopep_ABC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08352">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01727">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="4"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="353"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="41"/>
            <end position="48"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="393"/>
            <end position="400"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PJN09373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="618" mass="67048" checksum="C710D08019992E96" modified="2018-04-25" version="1">MALLEVTDLTVTYSPRGAEAVRAVHRVGLEVAEGEFVGLLGESGCGKSTLGNAILRLLEKPAAITGGSIVFDGRDITHAGEDELRARRWADLSTVFQSSMNSLNPVITVREQFADTYAAHPEAAGRDVDVDAQAGELLELVSLDRDVLRRYPHELSGGMKQRVALALALALRPKFVLLDEPTTGLDVVVQRDILDRLRELRRTLGFAVLFISHDLGTVMEMADRVLVMYAGEIVESRPAGDMVAAPLHPYSTGLLGSYADPRDEVVQVAFIPGRPPNLARDHEGCLFEPRCPVALDACRTRHPELLPVERGAARCLLVEESGGARPASARPASVFSAVGGAGSRVTADTEPVLVVEGVGKEYRSRRGFRTTTVRAVDEVSFALRPGRVGALVGQSGSGKTTIARMITGVERPTSGTIRFKDERVDTLGRRALRRYRRHVQLVFQDPFAALNPTRTIGYALSRPLRNYLGLNAGQARTRAAELLETVGLSPAEQYLDKLPGQLSGGQRQRVVIARALAPEPDVLVADEPISMLDVSIRAEIVELLDQLVRDRSIAMLYITHDLLSARLLADEVLVLNQGSLVEQGPTLDVIGHARDPYTRKLLAAIPRPDGARTVPSNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-09-29" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JSN1</accession>
    <name>A0A2M9JSN1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CG723_19290</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CB01635</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000006">
        <property type="protein sequence ID" value="PJN09889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN09889">
        <property type="protein sequence ID" value="PJN09889"/>
        <property type="gene ID" value="CG723_19290"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="41"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="73"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="105"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="130"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="159"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="193"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="241"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="277"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="308"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="331"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="370"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="395"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="7">
        <location>
            <begin position="35"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PJN09889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="429" mass="43445" checksum="BC4F0E02FD44F60F" modified="2018-04-25" version="1">MPPASSGAAATHAVAARKPSSPEAPDTRLNPGGPGYRRMSFALFLAGVATFALLYSTQALLPLVSADFGVSASAASWTVSGATGALALCVLPLSALSERFGRRTVMTASLSVAVAVGLLVPFAPSLGALIALRALQGAALAGLPASAMAYLAEEVRPKALVAAIGLFVAGNSIGGMSGRVITGWVAQEWGWRAAVATIGVIAVACAVAFRLLLPQPRHFTPGSLRPRVLARTVRGHLANPLLCRLYVIGALFMTVFGAVYTVIGYRLTAAPFSLPQGIIGSIFLVYLVGTVSSAAAGKLVARLGRRGALYLAVGTTASGLLLSLGDAIAMVLLGLVLITAGFFAGHAVASSSVSHTATHGRAQASALYQSVYYIGSSVGGTLGAVAFHAGGWAGTVALGLVAVLGVVSVTLWGSHAARVQQRQTLVAAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JSP2</accession>
    <name>A0A2M9JSP2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Sugar ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CG723_19325</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CB01635</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000006">
        <property type="protein sequence ID" value="PJN09895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN09895">
        <property type="protein sequence ID" value="PJN09895"/>
        <property type="gene ID" value="CG723_19325"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001851">
        <property type="entry name" value="ABC_transp_permease"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02653">
        <property type="entry name" value="BPD_transp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="21"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="63"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="96"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="122"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="149"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="204"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="252"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="330"/>
            <end position="349"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PJN09895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="381" mass="40057" checksum="AD2C414934242FE1" modified="2018-04-25" version="1">MKTLISRGKSRIDKERLILAVAAPLLAIIAALVVTAVIIAATGKDPFAAFSDMVTYGSASDSQVYILNKATTYYLAGVAVAIGFRMNLFNIGVDGQYRLAAFVAAVLGGALTLPGWLSIPLILLAAMATGALWAAIAGILKVTRGVSEVISTIMLNSIATAIIAYLLQPEQLGQLDEAGTLVSTKPLPESSNFFMIDAGPAGQVWGFIVIAVLVGVAYWFVLGRTRFGFDLRTVGQSESAAAASGVSVKKMVATSMVISGAVAGLVGMPTLLNDSHQYDNSFPVGLGFTGIAIALLGRNHPVGIALGALLWGFLERTTNHLEFQGYDKEILGVIQGVIVLCVVIAYEVVRRYGLKRQQQRVGAELAAQAAAVRTDKQEVAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JT66</accession>
    <name>A0A2M9JT66_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">tRNA (Adenosine(37)-N6)-threonylcarbamoyltransferase complex dimerization subunit type 1 TsaB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">tsaB</name>
        <name evidence="2" type="ORF">CG723_20095</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000006">
        <property type="protein sequence ID" value="PJN10022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN10022">
        <property type="protein sequence ID" value="PJN10022"/>
        <property type="gene ID" value="CG723_20095"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002949">
        <property type="term" value="P:tRNA threonylcarbamoyladenosine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000905">
        <property type="entry name" value="Gcp-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022496">
        <property type="entry name" value="T6A_TsaB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11735">
        <property type="entry name" value="PTHR11735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11735:SF11">
        <property type="entry name" value="PTHR11735:SF11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00814">
        <property type="entry name" value="TsaD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03725">
        <property type="entry name" value="T6A_YeaZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="TsaD" evidence="1">
        <location>
            <begin position="32"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN10022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="220" mass="22741" checksum="5ECD92D212E9818D" modified="2018-04-25" version="1">MLLLALDTATPAVTVALHDGSSVVAASSQVDARRHGELLLPAVDRVLAEAGVGLDAVTGIVVGVGPGPYTGLRVGLMTADTFGLALGVPVHGLCTLDGLAYGAEDASLDGPFVVATDARRKEVYWARYEDPRTRVTEPAVDRPADIAEQVAGLPAVGAGAVLYPDTFPDARAPENVSAAALASLAAEKLAAGEELDAPRPLYLRRPDAQVPKNYKVVTPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JTB6</accession>
    <name>A0A2M9JTB6_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA (cytosine-5-)-methyltransferase</fullName>
            <ecNumber evidence="2">2.1.1.37</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CG723_20705</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CB01635</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 2'-deoxycytidine in DNA + S-adenosyl-L-methionine = a 5-methyl-2'-deoxycytidine in DNA + H(+) + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:13681"/>
            <dbReference type="Rhea" id="RHEA-COMP:11369"/>
            <dbReference type="Rhea" id="RHEA-COMP:11370"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:85452"/>
            <dbReference type="ChEBI" id="CHEBI:85454"/>
            <dbReference type="EC" id="2.1.1.37"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.37" evidence="2"/>
    <dbReference type="EMBL" id="NNBL01000006">
        <property type="protein sequence ID" value="PJN10125.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN10125">
        <property type="protein sequence ID" value="PJN10125"/>
        <property type="gene ID" value="CG723_20705"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003886">
        <property type="term" value="F:DNA (cytosine-5-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009307">
        <property type="term" value="P:DNA restriction-modification system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001525">
        <property type="entry name" value="C5_MeTfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00145">
        <property type="entry name" value="DNA_methylase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00105">
        <property type="entry name" value="C5METTRFRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51679">
        <property type="entry name" value="SAM_MT_C5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6 8" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0680">Restriction system</keyword>
    <keyword evidence="6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4 6 8" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="261"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PJN10125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="403" mass="43221" checksum="47725A4B55EA385B" modified="2018-04-25" version="1">MTQPTDIRRAPDVSRPLRVVDALAAKSATGAGSSLIPNDIVELFRGPGGWAEGLRMLGLADIGLEWDAAACRTAHAAGHATIQTDVATYPTAPFKDRIAGLIASAPCQAWSRAGKRGGLADQALVHQAVHDLAHGRDTRAGLLAQCQDERSLLAAEPMRWLYDLRPEWACLEEVPDVLPLFQQYAGILRDWGYSVWVGILNAADYGVPQTRKRAILLASRIRHVTAPDPTHAKSPALDLFGGCLAPWVSMADALALPSGVTVNTRGDRPKDERGRAAGGNEFSADGPSNALTGRARSWKLRSGQGWKLPSGDVERYERALSEPSFTITSTASRCKWVGDGVEERSLTLAEAAILQSFRADHSFYGTRTKQFEQVGNAVPPLLAAHIVSVATGIPVRSTLEVAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JTI0</accession>
    <name>A0A2M9JTI0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Serine/threonine protein phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_17345</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000005">
        <property type="protein sequence ID" value="PJN10173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN10173">
        <property type="protein sequence ID" value="PJN10173"/>
        <property type="gene ID" value="CG723_17345"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006470">
        <property type="term" value="P:protein dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00143">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015655">
        <property type="entry name" value="PP2C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13832">
        <property type="entry name" value="PTHR13832"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00331">
        <property type="entry name" value="PP2C_SIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00332">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="SSF81606"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51746">
        <property type="entry name" value="PPM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPM-type phosphatase" evidence="1">
        <location>
            <begin position="3"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN10173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="267" mass="27446" checksum="5BD1AEFAC37499DF" modified="2018-04-25" version="1">MPYISVTALSHPGLRREHNEDSLVVGPWTLCGSVTENPQTMAFPLGHPLVVAVADGIGGQPAGEVASSLVVRRLALFGPALDGEEAVRDALGMCNHAVYAAADRAPELSTMGTTVAGVVILEQELLVFNVGDSRVIEVGPAGDGIETSADGGLTGDRAATDDTLHQVSVDDSPPLAHGRRTTSIVTQALGGAPTFSAITPHVSTSTLTPGTRMLVCSDGLTDPVLESEIDDVLREHDGGRAVFELWKAAMAAGGPDNVTIALVSLAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JTT6</accession>
    <name>A0A2M9JTT6_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">ATP synthase subunit b</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">ATP synthase F(0) sector subunit b</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">ATPase subunit I</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">F-type ATPase subunit b</fullName>
            <shortName evidence="13">F-ATPase subunit b</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="primary">atpF</name>
        <name evidence="16" type="ORF">CG723_18000</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">CB01635</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0).</text>
    </comment>
    <comment type="function">
        <text evidence="11 13">F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="12 13">F-type ATPases have 2 components, F(1) - the catalytic core - and F(0) - the membrane proton channel. F(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). F(0) has three main subunits: a(1), b(2) and c(10-14). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. F(1) is attached to F(0) by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13">Cell membrane</location>
            <topology evidence="1 13">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13 14">Belongs to the ATPase B chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000005">
        <property type="protein sequence ID" value="PJN10284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN10284">
        <property type="protein sequence ID" value="PJN10284"/>
        <property type="gene ID" value="CG723_18000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045263">
        <property type="term" value="C:proton-transporting ATP synthase complex, coupling factor F(o)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01398">
        <property type="entry name" value="ATP_synth_b_bprime"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028987">
        <property type="entry name" value="ATP_synth_B-like_membr_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002146">
        <property type="entry name" value="ATP_synth_b/b'su_bac/chlpt"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00430">
        <property type="entry name" value="ATP-synt_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81573">
        <property type="entry name" value="SSF81573"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 13" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="13" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 13 14" id="KW-0138">CF(0)</keyword>
    <keyword evidence="15" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6 13 14" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="8 13 14" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 13 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 13 14" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="15">
        <location>
            <begin position="40"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00025198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00025830"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01398"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU003848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="PJN10284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="158" mass="16895" checksum="329CD26008D9AD7D" modified="2018-04-25" version="1">MYLLPMKFGPLNAKIEVLAVALVLFAVVFLWFKRFLPRINQVLAERADRTEGALERAEAIHAEASAEHAGAQALLAEARRDAARVTQAAREEGAALIAAAREDGLREREALLADGQAVIEAERAAAEAELRLTVPELAAELASRIIGEPVPAAAPSNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JTX8</accession>
    <name>A0A2M9JTX8_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Phospholipase C</fullName>
            <ecNumber evidence="2">3.1.4.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CG723_17985</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CB01635</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O = a 1,2-diacyl-sn-glycerol + H(+) + phosphocholine</text>
            <dbReference type="Rhea" id="RHEA:10604"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17815"/>
            <dbReference type="ChEBI" id="CHEBI:57643"/>
            <dbReference type="ChEBI" id="CHEBI:295975"/>
            <dbReference type="EC" id="3.1.4.3"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="5">
            <dbReference type="Rhea" id="RHEA:10605"/>
        </physiologicalReaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial phospholipase C family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.4.3" evidence="2"/>
    <dbReference type="EMBL" id="NNBL01000005">
        <property type="protein sequence ID" value="PJN10282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN10282">
        <property type="protein sequence ID" value="PJN10282"/>
        <property type="gene ID" value="CG723_17985"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034480">
        <property type="term" value="F:phosphatidylcholine phospholipase C activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044003">
        <property type="term" value="P:modulation by symbiont of host process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017767">
        <property type="entry name" value="Bact_PC-PLC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007312">
        <property type="entry name" value="Phosphoesterase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008475">
        <property type="entry name" value="PLipase_C_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31956">
        <property type="entry name" value="PTHR31956"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05506">
        <property type="entry name" value="DUF756"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04185">
        <property type="entry name" value="Phosphoesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03396">
        <property type="entry name" value="PC_PLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0134">Cell wall</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0843">Virulence</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014760770" description="Phospholipase C" evidence="6">
        <location>
            <begin position="30"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="domain" description="DUF756" evidence="7">
        <location>
            <begin position="468"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="domain" description="DUF756" evidence="7">
        <location>
            <begin position="574"/>
            <end position="660"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF05506"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PJN10282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="670" mass="71347" checksum="72BBEAF25B47B794" modified="2018-04-25" version="1">MTPISRRGFVALGAGIAAGAALPATRAGAAATGTVKDVKHVVILMQENRSFDHYFGRLKGVRGFGDRSGITLSGGQPVFNQPSGLGRQYPWKLSSTPAAGGVDGETLAQCNGDLPHSWSSQHSAWNKGRLDHWVAGVGNVRSLGYLDRDDIPFHYALADNYTICDAYFSSTLSATGPNRTYLWSGKVDDSSHDGGDESGLTWETYAEALQRAGVSWKVYQNANDNYGDNGLAYFSKFAAAKPGDPLHDRGMGSVPAVTGSTPDDIAAAIKADALAGKLPQVSWVVANQAFSEHPYAPPGDGAHFVDLVHRALAASPEVFDSTVLFLNYDENDGFFDHVPPPSPPAGTAGEFLDGTPFGLGFRVPMVIMSPWTRGGWVSSEVFDHTSVLRFMETWTTALGTPATCPHISAWRRKVTGDLTGVFDFASPVYGMPSGLPATKVIGYNTCGPLPNPAPQTNALPTQEAGTRPARALPYQPNGNLDHFEFGAGGKILAWFSMANQGSPARSAAHLSIHPNAYRDTTPWQYTVDAGGTATDFFNIGAGSGSGAYDITMAGPNRFLRRFKGDATKAGKAIEVAARYAVESGTGKTAIWFKMTNSSSASAQFTITSNNYRSDGPWTYTVPAGGSTEDFFNAVANQKGWYDFTITSSTDTTWSRRYTGHIETGSASVSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JUG0</accession>
    <name>A0A2M9JUG0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GntR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_18845</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000005">
        <property type="protein sequence ID" value="PJN10514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN10514">
        <property type="protein sequence ID" value="PJN10514"/>
        <property type="gene ID" value="CG723_18845"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07377">
        <property type="entry name" value="WHTH_GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1410.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028978">
        <property type="entry name" value="Chorismate_lyase_/UTRA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011663">
        <property type="entry name" value="UTRA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
        <property type="entry name" value="GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07702">
        <property type="entry name" value="UTRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00035">
        <property type="entry name" value="HTHGNTR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00345">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00866">
        <property type="entry name" value="UTRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64288">
        <property type="entry name" value="SSF64288"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50949">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH gntR-type" evidence="1">
        <location>
            <begin position="7"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN10514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="249" mass="26895" checksum="2E1524E6E5CB1986" modified="2018-04-25" version="1">MTVPLGQPRRVAVYSRLAAGIRSQVFPLGSLLPKESDLGARLGVSRTVVREALMLLEEDGLIHTRRGVGRFVAPELPRAGLERLRPFEEVLASQGKAVGVENLQATIQHATDFVAGGLKLDPDANTWFWETRLTRDGEPVALVQEHIPAGRDLRDISPLLAERLRDPQDPGRTLFAVMTDLLGPVFGPGECAMTAGVAGATRGRLLSLPPSAPLLILTQTAQHGGRPAYLAKYIVRAGERLSINQPPQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JUK8</accession>
    <name>A0A2M9JUK8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">AsnC family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CG723_15255</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000004">
        <property type="protein sequence ID" value="PJN10575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN10575">
        <property type="protein sequence ID" value="PJN10575"/>
        <property type="gene ID" value="CG723_15255"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000485">
        <property type="entry name" value="AsnC-type_HTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019888">
        <property type="entry name" value="Tscrpt_reg_AsnC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019887">
        <property type="entry name" value="Tscrpt_reg_AsnC/Lrp_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01037">
        <property type="entry name" value="AsnC_trans_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00033">
        <property type="entry name" value="HTHASNC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00344">
        <property type="entry name" value="HTH_ASNC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50956">
        <property type="entry name" value="HTH_ASNC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH asnC-type" evidence="4">
        <location>
            <begin position="3"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PJN10575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="156" mass="16777" checksum="20C0B39AB0AEDC4B" modified="2018-04-25" version="1">MAIDHLDGQLILLLAREPRIGVLEASRRLGVARGTVQARLDRLQSNGVIRGFGPQVDPAALGYPVTAFATLQIRQGQGPDVRAHLTTVPEVLELHTTTGTGDMLCRLVARSNADLQRVIDRVVGFDGIVRASTAIVMENPVPLRIIPLVEQASSDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JUN1</accession>
    <name>A0A2M9JUN1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Antitoxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CG723_15040</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000004">
        <property type="protein sequence ID" value="PJN10538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN10538">
        <property type="protein sequence ID" value="PJN10538"/>
        <property type="gene ID" value="CG723_15040"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019239">
        <property type="entry name" value="VapB_antitoxin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09957">
        <property type="entry name" value="VapB_antitoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PJN10538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="73" mass="8392" checksum="00060FFE332E70F3" modified="2018-04-25" version="1">MAATQIDMDDEALAEAAMRLSGARTKKETVNRALREYGERQRRAEARLRHFKASQDWDDESFRRLHAAEKGTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JUV5</accession>
    <name>A0A2M9JUV5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WXG100 family type VII secretion target</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_15495</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000004">
        <property type="protein sequence ID" value="PJN10618.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN10618">
        <property type="protein sequence ID" value="PJN10618"/>
        <property type="gene ID" value="CG723_15495"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036689">
        <property type="entry name" value="ESAT-6-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010310">
        <property type="entry name" value="T7SS_ESAT-6-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06013">
        <property type="entry name" value="WXG100"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140453">
        <property type="entry name" value="SSF140453"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="110"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN10618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="134" mass="14902" checksum="BF8D21715CEAE26F" modified="2018-04-25" version="1">MGDPKDLRVPPEKLTKLADDLDGMQDHLDKQVKRMDTIVDSIEAGWSGPASTAYRGFHRAAAEDAVRIREVMKVLEQAVRMSRDGFTQLELDKLDQFRRIQVNVDVAGEADKLSTPNIDAPAPPSRPRSGLDSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JVB3</accession>
    <name>A0A2M9JVB3_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 6">Superoxide dismutase</fullName>
            <ecNumber evidence="2 6">1.15.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CG723_16670</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CB01635</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Destroys radicals which are normally produced within the cells and which are toxic to biological systems.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>2 H(+) + 2 superoxide = H2O2 + O2</text>
            <dbReference type="Rhea" id="RHEA:20696"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:18421"/>
            <dbReference type="EC" id="1.15.1.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the iron/manganese superoxide dismutase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.15.1.1" evidence="2 6"/>
    <dbReference type="EMBL" id="NNBL01000004">
        <property type="protein sequence ID" value="PJN10809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN10809">
        <property type="protein sequence ID" value="PJN10809"/>
        <property type="gene ID" value="CG723_16670"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004784">
        <property type="term" value="F:superoxide dismutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.990">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.55.40.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001189">
        <property type="entry name" value="Mn/Fe_SOD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019833">
        <property type="entry name" value="Mn/Fe_SOD_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019832">
        <property type="entry name" value="Mn/Fe_SOD_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019831">
        <property type="entry name" value="Mn/Fe_SOD_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036324">
        <property type="entry name" value="Mn/Fe_SOD_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036314">
        <property type="entry name" value="SOD_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02777">
        <property type="entry name" value="Sod_Fe_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00081">
        <property type="entry name" value="Sod_Fe_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000349">
        <property type="entry name" value="SODismutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01703">
        <property type="entry name" value="MNSODISMTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46609">
        <property type="entry name" value="SSF46609"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54719">
        <property type="entry name" value="SSF54719"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00088">
        <property type="entry name" value="SOD_MN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sod_Fe_N" evidence="7">
        <location>
            <begin position="4"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="domain" description="Sod_Fe_C" evidence="8">
        <location>
            <begin position="98"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="28"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="76"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="165"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="169"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000349-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000414"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PJN10809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="213" mass="23521" checksum="5B1DFC32428DBF2C" modified="2018-04-25" version="1">MAIYTLPELPYDYAALEPVINPQIIELHHDKHHAAYVKGANDTLEQLEEARDKESWGAINGLEKNLAFHLSGHILHSIYWHNMTGDGGGEPLATDGVGDLADAITASFGSFAGFKAQLTKAAATTQGSGWGVLAYEPVSGRLIVEQIYDHQGNVGQGSVPILVFDAWEHAFYLQYKNQKVDFIEAMWRVVNWQDVAKRYAAAKDRAFNLLLAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JVJ5</accession>
    <name>A0A2M9JVJ5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_16955</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000004">
        <property type="protein sequence ID" value="PJN10858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN10858">
        <property type="protein sequence ID" value="PJN10858"/>
        <property type="gene ID" value="CG723_16955"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024064">
        <property type="entry name" value="FdhE-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144020">
        <property type="entry name" value="SSF144020"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="27"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN10858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="75" mass="7692" checksum="DE24B5C3FEA58673" modified="2018-04-25" version="1">MPARITEAADRPLGVTVRPAEAAHSGQHVPSPSSSSSSSFPFLDCPSCGSFHVALMLGDNGGISYVCTACGHSWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JVW9</accession>
    <name>A0A2M9JVW9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_08200</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN10982.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN10982">
        <property type="protein sequence ID" value="PJN10982"/>
        <property type="gene ID" value="CG723_08200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="23"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN10982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="87" mass="9622" checksum="D8F87D526CB8959B" modified="2018-04-25" version="1">MGIFGPGVTRVPGLLRSERSDTMTWVVGTGAFLGMLAIASGIVTLRTGWILPMARRHVTRPRLHRAVCGWPLALRLGVMCLVRRLRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JW67</accession>
    <name>A0A2M9JW67_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CG723_09225</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN11131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN11131">
        <property type="protein sequence ID" value="PJN11131"/>
        <property type="gene ID" value="CG723_09225"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PJN11131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="185" mass="20598" checksum="B1ECB74ED5A487F2" modified="2018-04-25" version="1">MDSAVAGLLAAVVGVGGTLGSAWLTQRRGDASRREEWERLERTRRTELAAQHTESGRETRRAAYTEFNAAARHYLATLNDHNHVLRIGYAPQESLATVETARADYRRQYAEAQMIVPDIVLTEVRRVDIGLGSVYGILARLTHGTAGEGDDIENVRDVIKQGWRDLSRMREAMRTDLGVTGPTHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JWI4</accession>
    <name>A0A2M9JWI4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CG723_09985</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN11256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN11256">
        <property type="protein sequence ID" value="PJN11256"/>
        <property type="gene ID" value="CG723_09985"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006764">
        <property type="entry name" value="SAM_dep_MeTrfase_SAV2177_type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04672">
        <property type="entry name" value="Methyltransf_19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017393">
        <property type="entry name" value="MTase_SAV2177"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PJN11256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="270" mass="29662" checksum="29628902342FEED9" modified="2018-04-25" version="1">MGEITPPSIDRIDTSKPHPARVYDWFLGGKDNYPVDEELGRQIVALEPQSKYAAQHNRWFMQRATRHLAGAAGARQFLDIGSGIPTEPNLHRIAQGAAPDARVVYVDNDPIVLAHAGALLRGTPEGRTEYLSADVREPEKILELAADILEFDRPVTLSLIALLHFIPDSDGAHGLVRILVDALPPGSHLVLSQLAGDFDPERTREAVAMYAAGGVTLVPRTREEMGRFFDGLDLLEPGIVWLPDWHPELGVDEIRNESPVPLYAGVARKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JWK3</accession>
    <name>A0A2M9JWK3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_10095</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN11276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN11276">
        <property type="protein sequence ID" value="PJN11276"/>
        <property type="gene ID" value="CG723_10095"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN11276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="68" mass="6903" checksum="25899A36E6038A05" modified="2018-04-25" version="1">MTHPMPDPVTPPTPGPDVPDPGPFPSPIPTPPSPRPGPTPQPPPPPPSPGPPNPDPEPAPPEPEPSPM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-09-29" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JWN8</accession>
    <name>A0A2M9JWN8_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">zf-HC2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_10285</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN11311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN11311">
        <property type="protein sequence ID" value="PJN11311"/>
        <property type="gene ID" value="CG723_10285"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1320">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041916">
        <property type="entry name" value="Anti_sigma_zinc_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027383">
        <property type="entry name" value="Znf_put"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13490">
        <property type="entry name" value="zf-HC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="90"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="domain" description="zf-HC2" evidence="2">
        <location>
            <begin position="11"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN11311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="216" mass="22445" checksum="11538E23705A3B0F" modified="2018-04-25" version="1">MRSLDRHRDAGAYALGVLDEADRFRFEDHLGQCPGCVARVGGFGSTTAALALYARATPPAVETVAEAGPVLLDGLVSRMERVRRAGRRRWLCAMAAAVVLAVAGPGVVVLGGSGDGAVRLDARDAGTGVSASVTASGHEWGTGVGLEVHDARGPRVCELVVVGKDGSRQTVTSWAVRAHDAGATATQSAVALHPQEIARFEVRTTDGARLVTIPMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JWS8</accession>
    <name>A0A2M9JWS8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CG723_09630</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN11197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN11197">
        <property type="protein sequence ID" value="PJN11197"/>
        <property type="gene ID" value="CG723_09630"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020034">
        <property type="entry name" value="CHP03577_EF0830/AHA3911"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14272">
        <property type="entry name" value="Gly_rich_SFCGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03577">
        <property type="entry name" value="EF_0830"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PJN11197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="121" mass="12069" checksum="01C1051BEF63EC1A" modified="2018-04-25" version="1">MAVKIVIGHRLGKGQAVADGIRAAGGEPILIPGPGADMKVGDVMAAEGAALGISFCGSGGAGAVTAKAKYGHDIEFGMRSPQAGITAVQQGKTVLGFGFLDSEELGFKVTEALLKKLGESA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JXB6</accession>
    <name>A0A2M9JXB6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Dienelactone hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_10775</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN11397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN11397">
        <property type="protein sequence ID" value="PJN11397"/>
        <property type="gene ID" value="CG723_10775"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002925">
        <property type="entry name" value="Dienelactn_hydro"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01738">
        <property type="entry name" value="DLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DLH" evidence="1">
        <location>
            <begin position="32"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN11397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="271" mass="28482" checksum="0CAED35123229CD6" modified="2018-04-25" version="1">MTGSAPTSDLTGWQKAPFTGAGLTYDVYEKGSGPGVVLIPEIPGITPAVLGLADHLVAQGFTVAIPSPFGEPGREESVGYALKVLTRLCVASEFRAFATNARRPIADYLRALARDLASRTPGPGVGVIGMCFTGGFALAAAVDDVVLAPVLSQPSLPFPVSGARRVDPGLSRAEFDTVVSRSKESGLCVLGLRFSEDRAVPAQRFRTLREHLGDAFEVIELDSSPGNAGGFARTAHAVLTAEVREEPGNPALAARERVVSFLRERLVPKAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JXW3</accession>
    <name>A0A2M9JXW3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_12540</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN11688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN11688">
        <property type="protein sequence ID" value="PJN11688"/>
        <property type="gene ID" value="CG723_12540"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.130">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013517">
        <property type="entry name" value="FG-GAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028994">
        <property type="entry name" value="Integrin_alpha_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01839">
        <property type="entry name" value="FG-GAP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69318">
        <property type="entry name" value="SSF69318"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="80"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="262"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="35"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN11688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="542" mass="56143" checksum="CC509322BA8BDF57" modified="2018-04-25" version="1">MAVLHISSPAWHRGGPRATLLNRDLPDRNHGRSRGVQSVTHRRPRRNVLSRASRNRRRLSQALIACGCAVTLLAGCSEGDAREDRTADPAPRVPTGRGAGERGLGDFDRDGYDDFVTSLTTRNKFSQPTGYHLLVLPGSAKGLDPGRRRTYRDFFYGPLLRADLNGDGYTDLVATRTDHLAKDPARRDGPGAAVILPGGKKGLGDPVPVKAAGLVTASAATDVDGDGAVDLVYAGYHPHGNDTELPDRQGLVAYGPFGKDGAPARTTELENTASPGQAISGDFDSDGYGDVMFTDPSPDEADTDPPVDNGPYVTYFRGSPRGLTPARPPGNLGNDTYDGVLVPRSGDVDGDGIEDILAPGYREVGVAEGPASGRLTVAYGSKSGVGGGRPNAVFDQETPGVPGDSQGKDAFGRGAGTGDVNGDGHPDLLVDTPGEDQGNGRFTLLPGGSDGSPTGANATAFDLDTPGVPGKHDPSGGDGFAATFPLLDVNGDGRSDVVANAPGYRRGKGGLWLFPGTPEGLGTAGRIQFLDPSGLGLPPRTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JY14</accession>
    <name>A0A2M9JY14_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">zf-CGNR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_12910</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN11752.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN11752">
        <property type="protein sequence ID" value="PJN11752"/>
        <property type="gene ID" value="CG723_12910"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3300.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010852">
        <property type="entry name" value="ABATE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023286">
        <property type="entry name" value="ABATE_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021005">
        <property type="entry name" value="Znf_CGNR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35525">
        <property type="entry name" value="PTHR35525"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07336">
        <property type="entry name" value="ABATE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11706">
        <property type="entry name" value="zf-CGNR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160904">
        <property type="entry name" value="SSF160904"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="zf-CGNR" evidence="1">
        <location>
            <begin position="141"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF11706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN11752.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="191" mass="20470" checksum="89891C0F39512601" modified="2018-04-25" version="1">MRAGFPDFRLGSVLATSFTGTLSERHGNAVERIPTPHRLVDWLAANGLAVASCTTAQLDLARELRESIHAAATAAAIQDALPASAVQVINDCSTRGRAAAILTPEGERRWRLSSASCVEDALSVIAADAISIIAGERDGKLALCASPTCQAAFFDTSQSRTRKWCDMNTCGNRQKKARFNANQRKNPRSAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-05-25" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JY17</accession>
    <name>A0A2M9JY17_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Histidine kinase</fullName>
            <ecNumber evidence="3">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CG723_13070</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CB01635</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="3"/>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN11776.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN11776">
        <property type="protein sequence ID" value="PJN11776"/>
        <property type="gene ID" value="CG723_13070"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004673">
        <property type="term" value="F:protein histidine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038318">
        <property type="entry name" value="KdpD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025201">
        <property type="entry name" value="KdpD_TM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13493">
        <property type="entry name" value="DUF4118"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="15"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="44"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="93"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4118" evidence="5">
        <location>
            <begin position="19"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF13493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PJN11776.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="254" mass="26991" checksum="CB0D8FD72CA383FC" modified="2018-04-25" version="1">MTGNPLTGYPVRDRIALAAGLVCPFLVALVLVPFRTDLSSTNAALILVVVVVAVAAVGSRLAGAVAALSAAAWFDFFLTRPYQRFSITDSDDVETAVLLLVVGLIVSQLAARARRLKVVTVTDAEYLARIHGTADLAQSSTSADAVVGHVREQLTELLGLRGCRFEYGTLMGRPPRLEQDGTVVVGRRRWDVDSGGWPHGEIELRAYGNGRYLGRYMLTPGPGPVPSLQARLVAVTLADQTGAALDITRPAKGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JY71</accession>
    <name>A0A2M9JY71_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Short-chain dehydrogenase/reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_12770</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN11727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN11727">
        <property type="protein sequence ID" value="PJN11727"/>
        <property type="gene ID" value="CG723_12770"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN11727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="276" mass="28797" checksum="EFC88B8F70BBAC4D" modified="2018-04-25" version="1">MSVWFITGASRGLGAEIAREALARGHEVVATARDAEAVRRAFPDASDALLAVDLDVTEEATIRTAVDAALARFGRIDVLVNNAGRGLLGAVEEVSDAAVRNAFDINVFGVLGTLRAVLPTLREQRSGHVINIGSVGGFATAPGVGLYGATKFAVEAITEALHGELAPLGVHVTVVEPGGFRTDFLDASSLYTEPHVIDDYAPTAGATRKALADVNHRQPGDPAKAAAAVVGLAETPEPPLRLLLGADAVARVEAKLDLVTRELERNRVLAMSTDLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JY88</accession>
    <name>A0A2M9JY88_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_12885</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN11747.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN11747">
        <property type="protein sequence ID" value="PJN11747"/>
        <property type="gene ID" value="CG723_12885"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN11747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="139" mass="15088" checksum="C1EEC0CC463F9F8E" modified="2018-04-25" version="1">MVDGAPHIGDNNAYRRAGDMSPAGEKDARREAARIEPVLKRLWGQKEWDPESVRAALLKLGYAQEGSGDGGERAGGTLTVRGMDARYETDQYVTPEGAQVGLRVHADACVTAFVQETNYEVGVNGPYMETGCFEPPYGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JY99</accession>
    <name>A0A2M9JY99_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Carbamate kinase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">arcC</name>
        <name evidence="4" type="ORF">CG723_13530</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CB01635</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the carbamate kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN11853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN11853">
        <property type="protein sequence ID" value="PJN11853"/>
        <property type="gene ID" value="CG723_13530"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008804">
        <property type="term" value="F:carbamate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006525">
        <property type="term" value="P:arginine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04235">
        <property type="entry name" value="AAK_CK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1160.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036393">
        <property type="entry name" value="AceGlu_kinase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001048">
        <property type="entry name" value="Asp/Glu/Uridylate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003964">
        <property type="entry name" value="Carb_kinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30409">
        <property type="entry name" value="PTHR30409"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00696">
        <property type="entry name" value="AA_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000723">
        <property type="entry name" value="Carbamate_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53633">
        <property type="entry name" value="SSF53633"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00746">
        <property type="entry name" value="arcC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="AA_kinase" evidence="3">
        <location>
            <begin position="1"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRNR" id="PIRNR000723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PJN11853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="309" mass="32794" checksum="EF0D37A912E0DBE6" modified="2018-04-25" version="1">MRIVVALGGNALARRGEPMTADHLRANVRSTCEALAGLARQHELVITHGNGPQVGLLALQNLAYQDVAAYPLDILGAETQGMIGYVIQQELSNALAGEREVAAVVTTTEVDEADPAFERPTKLIGPQYSAQDAAEAAAEYRWTIARDGAAFRRVVPSPAPRRIVQAPLVRMLLENGRLVVCVGGGGVPVKIDGKGRQTGMQAVVDKDLASAALAAELKADMLVMLTDGDYVSENWGTPEQRDILTASPEAISELTFAEGSMKPKVDAAVRVAKAGGRALIGPLERIDDLLERRVGTEIRADVAEGIVFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JYC3</accession>
    <name>A0A2M9JYC3_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">3-dmu-9_3-mt domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_13670</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN11873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN11873">
        <property type="protein sequence ID" value="PJN11873"/>
        <property type="gene ID" value="CG723_13670"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06588">
        <property type="entry name" value="PhnB_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028973">
        <property type="entry name" value="PhnB-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06983">
        <property type="entry name" value="3-dmu-9_3-mt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="3-dmu-9_3-mt" evidence="1">
        <location>
            <begin position="6"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN11873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="138" mass="14841" checksum="049440C2CECDCD98" modified="2018-04-25" version="1">MASRLNPYISFAGDAKQAMEFYKSVFGGDLSVNTYSSFGSETPPGYADKVMHGMLEAPNGFTLMGADNPPGMELKQGNNFSVSLSGDDADELRGYWEKLSAGGNVAVPLEKQMWGDVFGMCNDKFGITWMVNISEAGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JYC9</accession>
    <name>A0A2M9JYC9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">SAM-dependent methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_13665</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN11872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN11872">
        <property type="protein sequence ID" value="PJN11872"/>
        <property type="gene ID" value="CG723_13665"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041698">
        <property type="entry name" value="Methyltransf_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13649">
        <property type="entry name" value="Methyltransf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransf_25" evidence="1">
        <location>
            <begin position="55"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN11872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="213" mass="23381" checksum="F9EFAB85E27B8641" modified="2018-04-25" version="1">MTETPSHHHATADAYDAVATLYAELVRNELDTQPLDRAVLAAFAELAQTNDGGPVAELGCGPGRVTAHLRNLGLDVFGIDLSPAMIDLARESYPDLRFEVGSMDALSLADGSLNGIVSWYSVIHTPPRDVPSCFDEFRRVLTPGGHLLLAFFESGDDPVTEFDHKVVTAYRWPIDDLAKTAAKAGFTEVGRMLREPREGERFRQGRLLMRRGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-06-02" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JYF8</accession>
    <name>A0A2M9JYF8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_13855</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN11905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN11905">
        <property type="protein sequence ID" value="PJN11905"/>
        <property type="gene ID" value="CG723_13855"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="27"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN11905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="109" mass="11732" checksum="1869B3601B2404A1" modified="2018-04-25" version="1">MLGGAAPRATIHSAGFRTHCSGHHARIRQRHEIQRDSWSGRRAYSKRRDTPWTTAQHQAHGTVSAPCPRGPVGTYNYRLAVTVEVAGIWADDSPAASAGIRADCGTGIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JYH5</accession>
    <name>A0A2M9JYH5_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">GDT1 family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CG723_13875</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CB01635</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Membrane</location>
            <topology evidence="1 6">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the GDT1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN11908.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN11908">
        <property type="protein sequence ID" value="PJN11908"/>
        <property type="gene ID" value="CG723_13875"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001727">
        <property type="entry name" value="Gdt1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12608">
        <property type="entry name" value="PTHR12608"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01169">
        <property type="entry name" value="UPF0016"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="38"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="64"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="98"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="137"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="170"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU365102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PJN11908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="193" mass="20353" checksum="244A2D64E83AF739" modified="2018-04-25" version="1">MTFDPLAFLTAFGLIFLAELPDKTMFASLAMGTRMRPLYVWFGTSTAFIVHVAIAVGAGSLLSLLPAMAVKLVSAALFAFGAVVLLRGGDDDDEEGAAKTVTGFWPVYTTAFMAVFISEWGDLTQITTANLAATNPWLPTALGSALALMSVSALALLVGRFIAKRVPLKTVQRIGAACMAGLAIWTLIEAFTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JZ35</accession>
    <name>A0A2M9JZ35_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Aspartate aminotransferase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CG723_10795</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CB01635</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 4 5">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the group II decarboxylase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN12142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN12142">
        <property type="protein sequence ID" value="PJN12142"/>
        <property type="gene ID" value="CG723_10795"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016831">
        <property type="term" value="F:carboxy-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019752">
        <property type="term" value="P:carboxylic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044249">
        <property type="term" value="P:cellular biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002129">
        <property type="entry name" value="PyrdxlP-dep_de-COase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021115">
        <property type="entry name" value="Pyridoxal-P_BS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00282">
        <property type="entry name" value="Pyridoxal_deC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00392">
        <property type="entry name" value="DDC_GAD_HDC_YDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="2" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="3 5" id="KW-0456">Lyase</keyword>
    <keyword evidence="4 5" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="4">
        <location>
            <position position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR602129-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PJN12142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="446" mass="47880" checksum="5464E37849300EFE" modified="2018-04-25" version="1">MDHLLHRLRLDPPPLGRLGDHQELTLALKDAIGPAPQPPADVLRTYTDALEPTVVSCDHPAFLAFIPGAPTKAAALFDMVLSASSLHGVSWLEASGAVAAENQVLRLFADLAGLPADAGGCFVSGGSAGNLSALVVARDTGRHRRALDERAPVRIAVSDQVHSSVGNTLRILGVEPLVVPTSDHRLTGEALRAALGAAERDGGAPVVAAVATAGTTNAGIIDDLEGVAEQTRARDLWLHIDAAYGGAALFVPELRERLRGIEHADSLVVDPHKWMFAPFDCGALLYRDPKPARAVHTQDASYLDAIHGADGADDETEWNPSDYAYHLTRRPRGLPLWFSLAVHGTDAYRDAVARGADIARRTARLVERTEGLELLREPELTVVLVRRTGWQPEDYYAWSKRLLASGTAFVTPSVWEGETVARLAFLHPDITEGTVRAILDSLVDEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JZ52</accession>
    <name>A0A2M9JZ52_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Fumarate reductase/succinate dehydrogenase flavoprotein subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CG723_11025</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN12149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN12149">
        <property type="protein sequence ID" value="PJN12149"/>
        <property type="gene ID" value="CG723_11025"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008152">
        <property type="term" value="P:metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003953">
        <property type="entry name" value="FAD-binding_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037099">
        <property type="entry name" value="Fum_R/Succ_DH_flav-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015939">
        <property type="entry name" value="Fum_Rdtase/Succ_DH_flav-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021133">
        <property type="entry name" value="HEAT_type_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004155">
        <property type="entry name" value="PBS_lyase_HEAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030664">
        <property type="entry name" value="SdhA/FrdA/AprA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11632">
        <property type="entry name" value="PTHR11632"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00890">
        <property type="entry name" value="FAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02910">
        <property type="entry name" value="Succ_DH_flav_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00567">
        <property type="entry name" value="EZ_HEAT"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46977">
        <property type="entry name" value="SSF46977"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="SSF48371"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50077">
        <property type="entry name" value="HEAT_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD_binding_2" evidence="4">
        <location>
            <begin position="15"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="domain" description="Succ_DH_flav_C" evidence="5">
        <location>
            <begin position="447"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="592"/>
            <end position="615"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PJN12149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="907" mass="95980" checksum="5C0804F96955F5C4" modified="2018-04-25" version="1">MAIPALSDATELSCDVLVIGGGTAGTMAALTAAERGADVLLLEKAHVRHSGALAMGMDGVNNAVIPGRAEPDDYVAEITRANDGIVDQSTVRQTATRGFAMVKRLESYGVKFEKDEHGEYAVRQVHRSGSYVLPMPEGKDVKKVLYRQLRRREMRERVRIENRVMPVRVLTRPEDGRAVGAAGFNTRTGEFVTVRAGAVILATGACGRLGLPASGYLYGTYENPTNAGDGYAMAYHAGAALTGIECFQINPLIKDYNGPACAYVANPFGGYQVNRHGERFVESDYWSGQMMAEFAAELASDRAPVYLKLSHLPEETITAVESILHTTERPTRATFHEGRGHDYRTHDIEMHISEIGLCGGHSASGVRVDAHARTTVPRLYAAGDLACVPHNYMIGAFVFGDLAGADASQFRAYEGELPGDQLAAAHELVYRPLRNPDGPPQPQVEYKLRRFVNDYVAPPKAGAKLSLAVEAFERMRGEIAGMGARTAHELMRCAEVSFIRDCAEMAARASLARTESRWGLYHERLDHPERDDAGWLHHLDVYKSPAGAMEFRARPVEPYVVPVPEFEPVAAGAERVLGEVALVPVATAGQRDVAPAARPATPAAAAPSPRATQAPASSPALLGVLSLAEESPGLDALSPYLADSDPAVRAAAVNVLAETVPAGAGPALAARLRDAAPQVREAAAGALRELVEVLPGEPELGTGLRAALDVTDPAVRGAALDVLRELRLGDASVYATALSDTDIDVRIHAVRALVSVDATGQLSAATADLARQVRVAVARGLAAVRDPAPAPLDPLLDDTDPLVRAAALTALAATGCPPPYAERAVAALDDPAWQVRAGAATALRTSLPSTAVPALAKASADPNADVRKAAVLSLLTHRADPDARAALATATTDSDADIRAYASRATT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JZC1</accession>
    <name>A0A2M9JZC1_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HTH lysR-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_13815</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN12219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN12219">
        <property type="protein sequence ID" value="PJN12219"/>
        <property type="gene ID" value="CG723_13815"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000847">
        <property type="entry name" value="Tscrpt_reg_HTH_LysR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00126">
        <property type="entry name" value="HTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00039">
        <property type="entry name" value="HTHLYSR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50931">
        <property type="entry name" value="HTH_LYSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH lysR-type" evidence="1">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN12219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="89" mass="9851" checksum="AF2A9FB0CB590F92" modified="2018-04-25" version="1">MTSRQIEIFVTVAEHLHFGRVAEALHISRPTVSQDVSRLERGPGLALFDRSRRSASLTLAGDAMAVEGRKLLSRAGEPRYGSFLLDDQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JZD0</accession>
    <name>A0A2M9JZD0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Sporulation domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_13955</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN12224.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN12224">
        <property type="protein sequence ID" value="PJN12224"/>
        <property type="gene ID" value="CG723_13955"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042834">
        <property type="term" value="F:peptidoglycan binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1070">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018711">
        <property type="entry name" value="NAGPA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007730">
        <property type="entry name" value="SPOR-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036680">
        <property type="entry name" value="SPOR-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09992">
        <property type="entry name" value="NAGPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05036">
        <property type="entry name" value="SPOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110997">
        <property type="entry name" value="SSF110997"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51724">
        <property type="entry name" value="SPOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SPOR" evidence="2">
        <location>
            <begin position="62"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN12224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="518" mass="53230" checksum="CE8B65930519EEF9" modified="2018-04-25" version="1">MSVPASSAPVPGSAGALPLGPADLPETRTTQQLQPGVTLTRIVRGADAPALGWTVEVSIPGGAGSPDPDAPPAALNDRASADELVAHLREDGFEARAEEVTTPATADFAGGTLGWRVRVGEFGSQSAATAERTRLRTVGFTGAAVYRGWDGEPTDRGPWRIDVLIIDPHGFRGALRASYGPDLENREKTSQLVAAAGATAGVNAGFFVLDPNAGAPGDPAGVGVYDGRLLSEPVGTRPSLVIQDSGRRTGVARLTWQSRLTGRGASIPLDGINRVPGLIRNCGGTADDTPTSLPLHDTTCKDDDELVALTGEFGGKTPSGEGIEAVLDRHGRVLEVRSPRGGSLPEGGSSVQATGRYVARLAELAQTGRQLRIQAVLKDADGRTVSPSTSTSILNGGPELVRDGRAHITVAADGMVQPGNPSFYYGWVHKRNPRTLAGVDAAGRTVLVTADGRSTGALGLSIPESAAVAKALGLRDAINLDGGGSTTMVADGHVINAPSDATGERPVGDALLILPGRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JZE2</accession>
    <name>A0A2M9JZE2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">AraC family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_14815</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN12241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN12241">
        <property type="protein sequence ID" value="PJN12241"/>
        <property type="gene ID" value="CG723_14815"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002818">
        <property type="entry name" value="DJ-1/PfpI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018062">
        <property type="entry name" value="HTH_AraC-typ_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01965">
        <property type="entry name" value="DJ-1_PfpI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00041">
        <property type="entry name" value="HTH_ARAC_FAMILY_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="2">
        <location>
            <begin position="212"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN12241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="312" mass="33590" checksum="901BFF5886A3D59F" modified="2018-04-25" version="1">MHTVAVLALDRVIPFDLSTPIEVFTRTRLPDGRPGYQIRVCAETPEIDAGAFTLRAPWGLEGLKGADTIIVPGTDAPAAPLAPAVRDALRAAAEDGTRIASICSGTFPLAATGLLDGLHATTHWIAADLLAAAYPDIEVDPDVLYVDNGQILTSAGAAAGLDLCLHMIRKDYGSAVAADAARLSVMPLEREGGQAQFIVHDRAPSPQGSVLEPLLNWLQENLGADLTLADIAAHAGTSTRTLIRRFREQTGTTPLQWLHRARIRQAQHLLETTRHSVERIGTQVGFGSPTAFRDRFKRTTGVSPHTYRRTFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JZP4</accession>
    <name>A0A2M9JZP4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_04700</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000002">
        <property type="protein sequence ID" value="PJN12355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN12355">
        <property type="protein sequence ID" value="PJN12355"/>
        <property type="gene ID" value="CG723_04700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="57"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN12355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="78" mass="8162" checksum="6D8EE4FE8866E96C" modified="2018-04-25" version="1">MVRLAEESDAQILVGILGVVLTLLGGLFLGFAALTSKVIREEGEEGRSAEAQKVRRTRAGSIAIGGLLVGVGVFLFFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JZP9</accession>
    <name>A0A2M9JZP9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CG723_04445</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000002">
        <property type="protein sequence ID" value="PJN12310.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN12310">
        <property type="protein sequence ID" value="PJN12310"/>
        <property type="gene ID" value="CG723_04445"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014935559" evidence="3">
        <location>
            <begin position="27"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="77"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="38"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="99"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="58"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="102"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="143"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="158"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="187"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PJN12310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="225" mass="22827" checksum="F269B78E41A7856C" modified="2018-04-25" version="1">MDYCHPCRRHLNGALACPGCGTPAEACRAHAEALAAQESAENAGAPYADEPTHTRRSRRERRERGARRAHRRRRNKIVIAAAGLALAAGGLSFAELGTESSADGDAQGSSTSAEEAADQEAQAAASSAAGTPTGAAAAEADPQASSASASPSPSASESEDAKKGKETEGAKEGTEGHATSVPAATPTPHTPTGPGTPAPGPTTTPPPPPQPTPTETCDRFLWWCT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K0Q7</accession>
    <name>A0A2M9K0Q7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_06135</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000002">
        <property type="protein sequence ID" value="PJN12607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN12607">
        <property type="protein sequence ID" value="PJN12607"/>
        <property type="gene ID" value="CG723_06135"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="35"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="214"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN12607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="276" mass="30122" checksum="ECC82C1ED1B042AC" modified="2018-04-25" version="1">MGWTVLYIAFGIVALWLLGEVLLQYKARLRFRLLAFVGFVGVVLGVLIPSVIVIGIGAITFAVGQTYVTLSFRRGFSTGWALGGNPGASKRRKLREPVHQDPVLEVSDLEYESAAPEPEPESAAEVTSVYAPQPMPDDTGQYGVYAPAAAHTDAAAQGYAYDAYAGYDQQQYGYDNGQQQYAAYSDPYIGTQTYPAQPQYDDAYGTGQQYGDPYANGGYGMETPSGGVWVPQQRTGDDQHQQYGGELPPEQPYPYEQNGQGGYDGGSGYNEQQYRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K0U6</accession>
    <name>A0A2M9K0U6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_07050</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000002">
        <property type="protein sequence ID" value="PJN12761.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN12761">
        <property type="protein sequence ID" value="PJN12761"/>
        <property type="gene ID" value="CG723_07050"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="52"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="87"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN12761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="159" mass="16408" checksum="3D1D8F7A430DA57A" modified="2018-04-25" version="1">MIEGPYFVLTVLGALACGVSAGVFIAFSTFVMKGLAALPPAQGIAAMQAINVVAVSPAFMVVFLGAAALCVVLAVVTFVLWPEQGTVELLLGSAFQLAGAFGVTVAANVPRNDALAKLAPEAPDSEGPWRRYVSEWLMWNHIRGGASLAASASFVLALT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K0V2</accession>
    <name>A0A2M9K0V2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycerophosphodiester phosphodiesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_07115</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000002">
        <property type="protein sequence ID" value="PJN12773.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN12773">
        <property type="protein sequence ID" value="PJN12773"/>
        <property type="gene ID" value="CG723_07115"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008081">
        <property type="term" value="F:phosphoric diester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030395">
        <property type="entry name" value="GP_PDE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017946">
        <property type="entry name" value="PLC-like_Pdiesterase_TIM-brl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03009">
        <property type="entry name" value="GDPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51695">
        <property type="entry name" value="SSF51695"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51704">
        <property type="entry name" value="GP_PDE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014637730" evidence="1">
        <location>
            <begin position="28"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="domain" description="GP-PDE" evidence="2">
        <location>
            <begin position="34"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN12773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="291" mass="31537" checksum="B373BB3469AF8E93" modified="2018-04-25" version="1">MSARAATATAALVGFVGVLVLPTTAEAAQKHGGPAVVAHRGASGYAPENTLKAIDKADRLGFDWVENDVQRTKDGRLVVIHDTNLARTTNVEQVFPGRAPYNVRDFTAAEIAELDAGAWKGAEFTGAHVPTLTQYLDRIDHNHQKLLMEIKAPELYPGIEKDILRVLGKEGWLNRDHVRNRLVIQSFSADSVRTVHKHRPDITTGFLGTPAKSDLPRYAQFADRINPSNGTISAGYVAAVHAFRGPHGKRLKLFTWTVNDAATARRVAGLGVDGIISNFPDVVRKAVGGGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K0Y9</accession>
    <name>A0A2M9K0Y9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Carbohydrate kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CG723_07180</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000002">
        <property type="protein sequence ID" value="PJN12786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN12786">
        <property type="protein sequence ID" value="PJN12786"/>
        <property type="gene ID" value="CG723_07180"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016773">
        <property type="term" value="F:phosphotransferase activity, alcohol group as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002173">
        <property type="entry name" value="Carboh/pur_kinase_PfkB_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011611">
        <property type="entry name" value="PfkB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00294">
        <property type="entry name" value="PfkB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="SSF53613"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00584">
        <property type="entry name" value="PFKB_KINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PfkB" evidence="3">
        <location>
            <begin position="2"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PJN12786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="308" mass="31696" checksum="BE351FEF46F3B3D3" modified="2018-04-25" version="1">MIVVAGEALIDLVPQGGAADDGGDLPSLAPRLGGGPFNTAVAVGRLGSPVAFCSRVSRDAFGEALLGGLARAGVDVSYVQRGDEPTTLAVATIAADGSAGYSFYVDGTADRLFSMPDRLPPGTRAVSFGTCSLVLEPGASAYEELMRSASAQGVFTALDPNIRAGLIPDPDAYRARFKSWLPSIGLLKLSEEDARWLGGTPQEWPASGPAAVVITRGGDGLTVFTRGGARYDVPGERVDVVDTIGAGDTVNAALMHGLAAWDALSVEAVAGLGEDDWHRLLRFAARAAAVTCSRAGAEPPYASELPPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K123</accession>
    <name>A0A2M9K123_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_06850</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000002">
        <property type="protein sequence ID" value="PJN12727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN12727">
        <property type="protein sequence ID" value="PJN12727"/>
        <property type="gene ID" value="CG723_06850"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="205"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN12727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="225" mass="23994" checksum="3AFBE7E76D7A150B" modified="2018-04-25" version="1">MAGIGPVEPEPPSGDGTPHTPAHTDTLWAGSPNSPHLHDRWAALPPHLRRTLQALLAAAAITGAYAYTALTTTPATPAPTPWPSQVTFLHYEGTSPPDPHHPRTATFRFTVSVRDTHPVTIRQVRAGLPGLSAHAIPALPLTVKGGAPKPLTVRISVYKCAALPPGFTLPHLDLGLRNRQAQQQHSYLFGGAFPRDLATYLHDACGPRAGHSGPPRGPRTDLTRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K129</accession>
    <name>A0A2M9K129_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CG723_07405</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000002">
        <property type="protein sequence ID" value="PJN12829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN12829">
        <property type="protein sequence ID" value="PJN12829"/>
        <property type="gene ID" value="CG723_07405"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PJN12829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="78" mass="8358" checksum="5B9A2ADF691FB1B9" modified="2018-04-25" version="1">MRDIVLALAVPLLICASGVYAACDGWWRRRHPAPAPHSHAGRRLAAERAVADAEAIVADRYAILAEAERSAARLGGQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K1E8</accession>
    <name>A0A2M9K1E8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">HNH endonuclease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_08065</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000002">
        <property type="protein sequence ID" value="PJN12948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN12948">
        <property type="protein sequence ID" value="PJN12948"/>
        <property type="gene ID" value="CG723_08065"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00085">
        <property type="entry name" value="HNHc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002711">
        <property type="entry name" value="HNH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003615">
        <property type="entry name" value="HNH_nuc"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01844">
        <property type="entry name" value="HNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00507">
        <property type="entry name" value="HNHc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HNHc" evidence="1">
        <location>
            <begin position="71"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00507"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN12948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="168" mass="18679" checksum="881E046C9EBE5F73" modified="2018-04-25" version="1">MRDTLVLNASFEPLSTVTLNRAVVLVLQDKAVVEQAHPGLRVRAAAVDIPVPQVIRLCRYVRVPFRRQAPWSRRGVLVRDQHRCAYCGRRATTVDHVVPRSRGGADSWLNTVASCAEDNHRKADRTPEQAGMPLLREPFEPTPADAMLLTLGQSERDALPAWLARTAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K1R4</accession>
    <name>A0A2M9K1R4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_00210</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000001">
        <property type="protein sequence ID" value="PJN13066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN13066">
        <property type="protein sequence ID" value="PJN13066"/>
        <property type="gene ID" value="CG723_00210"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011852">
        <property type="entry name" value="TRAP_TAXI"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42941">
        <property type="entry name" value="PTHR42941"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16868">
        <property type="entry name" value="NMT1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02122">
        <property type="entry name" value="TRAP_TAXI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN13066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="331" mass="35803" checksum="64973376537310D5" modified="2018-04-25" version="1">MHKALPRVSRRRALEGSAAALVVLGLLLWWLLPLDDGTPGGNVTFSTGQRTGVYERYGNLLKTALGHDLPDLDVRLTNSEGSQENVERVATGKADFTIAAADAVEKYKLQGGAGGDRLRGCARLYDDYVQLVVPRSSSIRSVQDLRGRKVAVGGKGSGVRLIAERVAKAAGLDLERDMNPVSTGIDGMPQALKDGDIDAFFWSGGLPTNHVRKLSENYPIRLVELGNLVDALHKQGGASRYYRAAVMPADAYPDAQQGVSVPTLAVANLLVTTDRADPRLTEALTRTVIDSRDHIGTQVHAAQLVDLRTALYTDPLALHEGARRYYRSVKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K1V2</accession>
    <name>A0A2M9K1V2_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Citrate synthase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CG723_00480</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CB01635</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>acetyl-CoA + H2O + oxaloacetate = citrate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16845"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16452"/>
            <dbReference type="ChEBI" id="CHEBI:16947"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="EC" id="2.3.3.16"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Carbohydrate metabolism; tricarboxylic acid cycle.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 5 7">Belongs to the citrate synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000001">
        <property type="protein sequence ID" value="PJN13114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN13114">
        <property type="protein sequence ID" value="PJN13114"/>
        <property type="gene ID" value="CG723_00480"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00223"/>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036440">
        <property type="term" value="F:citrate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016142">
        <property type="entry name" value="Citrate_synth-like_lrg_a-sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016143">
        <property type="entry name" value="Citrate_synth-like_sm_a-sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002020">
        <property type="entry name" value="Citrate_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019810">
        <property type="entry name" value="Citrate_synthase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024176">
        <property type="entry name" value="Citrate_synthase_bac-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036969">
        <property type="entry name" value="Citrate_synthase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11739">
        <property type="entry name" value="PTHR11739"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00285">
        <property type="entry name" value="Citrate_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001369">
        <property type="entry name" value="Citrate_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00143">
        <property type="entry name" value="CITRTSNTHASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48256">
        <property type="entry name" value="SSF48256"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00480">
        <property type="entry name" value="CITRATE_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5 7" id="KW-0808">Transferase</keyword>
    <feature type="active site" evidence="6">
        <location>
            <position position="273"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010566"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR001369"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR001369-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PJN13114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="388" mass="41566" checksum="08500CDB38F33392" modified="2018-04-25" version="1">MPINGTTAAPVDVPRGLAGVVVTDTELGDVRGREGFYHYRQYSAVELARTRSFEDVWHLMIHGELPDAARSAAFATRTAALRRLPDDVRAALPVIARAGALSGPLAGLRSALSLFGASQGFRPVYDIDDGRRRDDTLAAAAVVPTLLTALHRLGDGLEPVEPRDDLSYAANYLYMLTGSEPEPAHTRAIEQYLISTIDHGFNASTFTARVITSTGADVAACLVGAVGALSGPLHGGAPSRALDTLDAIGTPDRIDGWIRERVLAGDRIMGFGHPVYRTEDPRSRMLRGIAEGFGGPMVEFAVEVERHVESILAELKPGRELHTNVEFYAGVVMELCGLPRTMFTPTFAAARVVGWSANILEQARDSKIIRPAARYVGPAAPVPVPVVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K321</accession>
    <name>A0A2M9K321_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Aminopeptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_02895</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000001">
        <property type="protein sequence ID" value="PJN13525.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN13525">
        <property type="protein sequence ID" value="PJN13525"/>
        <property type="gene ID" value="CG723_02895"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044249">
        <property type="term" value="P:cellular biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminotran_1_2" evidence="2">
        <location>
            <begin position="72"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN13525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="419" mass="43593" checksum="69105C39CE2483B8" modified="2018-04-25" version="1">MRGNDHGILEGHGPVRYGPPLPDDGLPVLPELAATAAAADPAAPEPPGGSPSLLDAACGYWQRRGLPTEPGGTAAAPGGVPLLLALTAAIGGDVLLPRPCPAWWEPQARLLGRSVFHVATPAECGGVPDPYALLETARRVRAEGGDPRLLVLSVADDPTGTVPPPEILHEAVEAAAQEGLHIVSDETWRDTLHHDPARATVLIGPAEMLPEHVTVVTDLTGAYLPPGLPAAVARFPATARGAALRARVLDILTALGAVLPAPAAAAATYALGEPAGITERLRATTALHARVAAAVHRAVLLSGGLARPPEAGRQLYADLDRLRPALAARGVGDAQDLEDRLSERLGMPTPGGHRFGDNLAALRVRLSTSPFLGSTPQERMTSLTAPEPLELPHVQRALSMLESALDDLRADVKGWESPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K3C0</accession>
    <name>A0A2M9K3C0_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Lactamase_B domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_02910</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000001">
        <property type="protein sequence ID" value="PJN13527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN13527">
        <property type="protein sequence ID" value="PJN13527"/>
        <property type="gene ID" value="CG723_02910"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12706">
        <property type="entry name" value="Lactamase_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lactamase_B" evidence="1">
        <location>
            <begin position="21"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN13527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="257" mass="27715" checksum="25DDA0A5AF71A8BD" modified="2018-04-25" version="1">MPVEITWWGHATCTVEDSGIRVLTDPLFTRRLAHLRRRRGAPPPPEAAVADVALVSHLHADHLHVPSLARLAPGTRVLLPRGARRAVPGLRRLTHLRLTEVEPGTRVEVGDLVVRAVPASHDGRRIPVGPHRSPALGFVVSGEARTYFAGDTGLFDSMAEAVGEVDVALLPVGGWGPCLGPHHLDAGRAAEALARIAPRSAVPVHYGTYWPIGMDAVRPHEFHAPGEEFVRRSAQLAPEVTVHLLGHGESVRPEVAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K3U9</accession>
    <name>A0A2M9K3U9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="11">NHLP bacteriocin export ABC transporter permease/ATPase subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CG723_03340</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000001">
        <property type="protein sequence ID" value="PJN13792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN13792">
        <property type="protein sequence ID" value="PJN13792"/>
        <property type="gene ID" value="CG723_03340"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022515">
        <property type="entry name" value="NHPM_micro_ABC2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221">
        <property type="entry name" value="PTHR24221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="SSF90123"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03797">
        <property type="entry name" value="NHLM_micro_ABC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="384"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="417"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="495"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="522"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="603"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="636"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="10">
        <location>
            <begin position="384"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="9">
        <location>
            <begin position="694"/>
            <end position="925"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="227"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="229"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="728"/>
            <end position="735"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PJN13792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="929" mass="100187" checksum="A4B2FAFF9E227E83" modified="2018-04-25" version="1">MPVDCAGMRSLNLEGPQVLWLVVQGALDLFAVDAAAQGHWHFLGRLEAGTLLLGPVEGPQHTLVGRPLQGCLLRRIGLRELQRPDYGDASWSYDQQYLSQYDTQDAALSLLEHAFALGVGRSQRVLFEAPLDGRTVGDDSVGDDDILWLPILPGSVQYGASYSADTVGELLVDGSMWQRMVNQQFRLLSALDRWIERLENAHETRTAAGIKAGETVREEADRTLLASIGRQGKGSSRRGSSSGNSDDATYAACKLVAGAAGITLAAPERSGAVSDRVDPVEQVAVASRIRTRAVRLDGRWWRENAGPLVGHRTSGTPVALLWRRGGYEAVHPSSGRRTRIDEDNAEEFEQRAVMLYRPLPDRALSPLRLLRFSARGTRADVRNLLLAGLVTVAIGALVPVATGRVLGVYVPNAETDLIVQVSLAVMVTSIVSAAFMLLQNLTILRMEGRIESALQPAVWDRLLRLPTRFFASRSTGELASAAMGISSIRRLMSGVGPVVVQSGTVGAMNLVLLLLYSVPLALTALAMLAVIAGVFLTLGLWELRWQRRLVVLGNKLNNQAFQTLRGLPKLRVAGAESFAYASWAGEFARSRELQRRAGRIKNLTTVLNAVYLPLCSLVMFMLLAGPARGTLSAGDFLTFSTAVTMLLSSVTQLTGALISAAAVLPMFEQIKPVLDEAPEVRAASTQPGELTGEIEARGVSFRYTDDGPLVLDDVNLSIRPGEFVAVVGPSGCGKSTLLRLLIGFDKPVSGGVLYDGQDLGALDQAAVRRQCGVVLQNAQPLTGSILDCICGAEVFTQEEAWEAAAMAGLAEDIKRMPMGLHTMIAGGGAISGGQRQRLMIAQALIRRPRILFFDEATSALDNETQRTVIDSTRALKATRVVIAHRLSTVMDADRVIVMADGRVVQQGPPAQLLADTNGRLHELVRRQMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-09-29" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JF25</accession>
    <name>A0A2M9JF25_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alpha-L-fucosidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_44495</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000047">
        <property type="protein sequence ID" value="PJN05505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN05505">
        <property type="protein sequence ID" value="PJN05505"/>
        <property type="gene ID" value="CG723_44495"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004560">
        <property type="term" value="F:alpha-L-fucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016518">
        <property type="entry name" value="Alpha-L-fucosidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027414">
        <property type="entry name" value="GH95_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14498">
        <property type="entry name" value="Glyco_hyd_65N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF007663">
        <property type="entry name" value="UCP007663"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="SSF48208"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glyco_hyd_65N_2" evidence="1">
        <location>
            <begin position="23"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN05505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="780" mass="84858" checksum="6A1A1CF9719F4236" modified="2018-04-25" version="1">MPLNAFAGTDHSDPITPLPAGSLWYRAPAARWFEALPIGNGRLGGMVYGGTDVDRIQLSESTAWSGAPSETDVSESGREQLATIRALLFAGEHAKAQELSAEHLLGHPTSFGTNLPLPEVRIEHLATGPVQDYRRSLSLDDGIVQSSFTRSDVTYATEVLASHPARVVAYRVAASTPGALSLQVGVGEAVFPLTRRTADGDLVLSGRAVETLHSNGRDGVDLTIRIRLVADGGTQDTYDNTLRLDGADAATLLVAVGTSWRGGTPDSDAATALNAAARQEWPHLRAAHVADVSALMGRAALDLGRTDPALGALPTDERRDLLARGGEDPELLALYFQYGRYLTVAGSRHDSPLPLALQGLWNDGLASSASWTNDFHLDMNTQQNYWAAEPTGLPECQEPLLRLVENLRRSGRDTASRLYGARGWVAHTVTNAWGYTAPGRGMGWGLNVTGGAWIALQHWERWEYGQDTDFLRERAYPVLKEAAEFFLDYLVPEPEHGWLVTGPSDSPENWYLAPSGAECSVSMGPTADRVFVEAVFRMCEEASHHLDVDAAFRERIAETRRRLAPFRIGRHGQLQEWLHDFEEAVPSHRHTSHLMALYPERQISPRTTPELAEAARVTIDRREAAPGWEQTEWAEANFIAYYARLLDGDTALHHVRSLVADASEANLLSFSRGGVAGAAQNIYSFDGNAGGTAGIAEMLLQSDGADTELLPALPAAWPHGHVRGLRARGGIHVDITWSGGRLQRATLRAAAPRQVRVRYRDNSLALSLLPGQSCEVTPDH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JFF1</accession>
    <name>A0A2M9JFF1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CG723_43790</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000044">
        <property type="protein sequence ID" value="PJN05620.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN05620">
        <property type="protein sequence ID" value="PJN05620"/>
        <property type="gene ID" value="CG723_43790"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PJN05620.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="168" mass="19022" checksum="5CF7FD860CEEF1D1" modified="2018-04-25" version="1">MTTPNEPTGKLNNQAPHLDYYPEWLDSLAADVVLQGNFANGEVIGKEKVGKLLSFARSNYAFQDFRFFGKRGELFLEDYRSTIRGSETYRPGGIEIYNFVVVYFNEAGETSQLVMNHRPQSAALLFSSLLAEHFGDEFGSDLFYKGDVSDRLLDHDLSRGQWPPSQSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JFF4</accession>
    <name>A0A2M9JFF4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_43765</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000044">
        <property type="protein sequence ID" value="PJN05618.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN05618">
        <property type="protein sequence ID" value="PJN05618"/>
        <property type="gene ID" value="CG723_43765"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="45"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN05618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="89" mass="9414" checksum="93212A27549E7CD1" modified="2018-04-25" version="1">MRGTDTAFGPAAVAVLALGHQQLSEETRIATQGQAPLPQSLLCRYARTVMTAVSFLTATGAVLSVARQTSRRTTFVGVLNRARLRKAAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JGJ5</accession>
    <name>A0A2M9JGJ5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_41920</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000037">
        <property type="protein sequence ID" value="PJN06005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN06005">
        <property type="protein sequence ID" value="PJN06005"/>
        <property type="gene ID" value="CG723_41920"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014929073" evidence="2">
        <location>
            <begin position="33"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="37"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="37"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN06005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="214" mass="21617" checksum="0780E770B8F08CAE" modified="2018-04-25" version="1">MSAGPSGKKPASRRRRSMTAVLAVLAATTSAAALVSCSTDSGNGSSSSVSPRPTPPNTASFSGTPPSAMASAAESAVASAKAEASAAASSASARASEFEASVSAEVERANAAAASELLKVKGQGNAMADVALTGKPRSQTGGVFAVVVNITNRTDKKASYAVQVDFKDADGKVVETRYVGAENLDPGERAQPLAISRKPPEMKLTAKIAKAQRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JGM2</accession>
    <name>A0A2M9JGM2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CG723_41270</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000036">
        <property type="protein sequence ID" value="PJN06039.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN06039">
        <property type="protein sequence ID" value="PJN06039"/>
        <property type="gene ID" value="CG723_41270"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PJN06039.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="95" mass="9955" checksum="CF671DD25E5E3028" modified="2018-04-25" version="1">MPLGGHASVPDPGSGRVRLDHQRRNLGQVREVAQLLVALQHYHQRQIEPVAALTTFGAVWAVLAVGHNLAEYVIGQTDRQAAGKGAPCGVSGGLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JGR0</accession>
    <name>A0A2M9JGR0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DUF4839 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_41500</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000036">
        <property type="protein sequence ID" value="PJN06071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN06071">
        <property type="protein sequence ID" value="PJN06071"/>
        <property type="gene ID" value="CG723_41500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032290">
        <property type="entry name" value="DUF4839"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16127">
        <property type="entry name" value="DUF4839"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="56"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="80"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="95"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN06071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="241" mass="25759" checksum="1C0BE78CFB5E2FA1" modified="2018-04-25" version="1">MADEIKYEYKTVQTVRGTDGLVISKMQKDGWVLVEKAQGTLRSTLSFRRPKKPQPWLLIGTAAAVLVILAIVIGATSALSDGGEKKDESDKSTAAASEKPSATPTPTTAESAATEVITPQHNPEFAALLKADSCDDANLDFATQHGGQTVAFNGSIVSMAPHGDYDTRYDFLLGPGDKGPNTTVGPAFKYEDVNIFDLKLTGKKIPATVGAGDKFRFVAKVGKFNADQCVFFLDPVSTEVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JHA5</accession>
    <name>A0A2M9JHA5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_40215</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000033">
        <property type="protein sequence ID" value="PJN06245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN06245">
        <property type="protein sequence ID" value="PJN06245"/>
        <property type="gene ID" value="CG723_40215"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009476">
        <property type="entry name" value="DUF1097"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06496">
        <property type="entry name" value="DUF1097"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="83"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="110"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="139"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN06245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="196" mass="20929" checksum="E061A353E15A1C17" modified="2018-04-25" version="1">MRERLSHEIVASVLAGLTAFIGGTALHLPPWAIFISWAAVFALGGPSWANARRLWCTMPAGSAFALVIVLIDQHVGTAFGDSQFARNTVLALVIMVVNTVLMYTGRIKVFSLIPGMFLGFASYFATFFGGFGYKPGNIWAAWVCVVAMNALGPVFAYLSNRLMYPILSPVPTSVVASAGPVHHDGRTPPAETAPAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JHD9</accession>
    <name>A0A2M9JHD9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Serine hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CG723_40590</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CB01635</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S9C family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000034">
        <property type="protein sequence ID" value="PJN06177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN06177">
        <property type="protein sequence ID" value="PJN06177"/>
        <property type="gene ID" value="CG723_40590"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008236">
        <property type="term" value="F:serine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001466">
        <property type="entry name" value="Beta-lactam-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011659">
        <property type="entry name" value="PD40"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001375">
        <property type="entry name" value="Peptidase_S9"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00144">
        <property type="entry name" value="Beta-lactamase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07676">
        <property type="entry name" value="PD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00326">
        <property type="entry name" value="Peptidase_S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase_S9" evidence="4">
        <location>
            <begin position="447"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-lactamase" evidence="3">
        <location>
            <begin position="676"/>
            <end position="995"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PJN06177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="1118" mass="119293" checksum="CD2A594304F8B87C" modified="2018-04-25" version="1">MTRRLGIDDLYELTVPEQPSVSPDGSRIVYVLRAADRDGDRDVRALWQVAAAGGEARQLTRGTTDTAPTWSPDGTRIAFLRARDSAPQLWFLPTAGGEAEQVTELPLGAGAPVWSPDGNKVAFAAPVDLAAADGEEATARARRAHAPVVADRLDFKADGTGLLRTVRKHVHVLDVGTREIRQVTSGDWNAGDPTWSPDGTRLAFPGASEPDADLTLRSAAYVLDLTERAAEPQLTGSGDGIAATVTWTLDGQALLVVGRGDTEIGHTKLLLVPLDDGDTVDLTAALDRNVMPGGPGYPGAAPCPTADGRVLFCVRERGCTHLYSVGLDGNAPRPVVGGAGNTVGDLAVAGDTVAILLATPSSFGEIATVDPADGTVEARTHHGESVADVELFAREEREFTISDGTVVHGWLVRDLARTGPSPLLLDIHGGPHNAWNGTADATHIYHQVLAARGWAVLLLNPRGSDGYGEKFLTAALGAWGQADAPDFLEPLDHLVAEGVADADRLAVSGYSYGGFMTCYLTSRDNRFAAAVAGGVVSDLTSMAGTSDAGHYMSVRELGGTPWAEEQPYPQQSPLTHVDQVQVPTLIVQGADDVRCPVGQAEQWFTALRERGVPARLVLYPGSSHLFILDGRPSHRADFNRRVVDWVERHARPKGSAARVPIDAAHWQRRLSELACAHRVPGAALGILRIGGDGADDLVQASHGVLSKNTRVEVTDDSLFQIGSITKVWTTTVVMQLVDEGLLDLDAPIADVLPELRLADPDVARQVTMRHLLTHTSGIDGDVFTDTGRGEDCLERYVDQLAGVGQNHPLAATFSYCNSGFVLAGRVIEKLTGKNWDIAMRERLFTPLGLSHTITLPEEALLFRAAVGHLSRRDGEPTSAPVWGLPRSVGPAGLVGAATADVLAFARLHLTGGLAPNGERALTRASVDAMADKQTDLPDPHSIGDSWGLGWIRFDWDGHQVVGHDGGTIGQAAFLRLLPEQGLAVVLLTNGGSPRDLYEGLYREIFAELAGVAMSRPLEPAAVPPAVDARRHAGVYERAGVRAEVLLTGERLRLRQTLTGPLAELTPDPTQEYDLVPVSDSLFVFRAPESRTWTPVTFYTLPTGEPYVHYGVRAAPKVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JI35</accession>
    <name>A0A2M9JI35_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Alkyl hydroperoxide reductase AhpD</fullName>
            <ecNumber evidence="6">1.11.1.28</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Alkylhydroperoxidase AhpD</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">ahpD</name>
        <name evidence="8" type="ORF">CG723_38225</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CB01635</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>(R)-N(6)-dihydrolipoyl-L-lysyl-[lipoyl-carrier protein] + a hydroperoxide = (R)-N(6)-lipoyl-L-lysyl-[lipoyl-carrier protein] + an alcohol + H2O</text>
            <dbReference type="Rhea" id="RHEA:62636"/>
            <dbReference type="Rhea" id="RHEA-COMP:10502"/>
            <dbReference type="Rhea" id="RHEA-COMP:16355"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30879"/>
            <dbReference type="ChEBI" id="CHEBI:35924"/>
            <dbReference type="ChEBI" id="CHEBI:83099"/>
            <dbReference type="ChEBI" id="CHEBI:83100"/>
            <dbReference type="EC" id="1.11.1.28"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homotrimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the AhpD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.11.1.28" evidence="6"/>
    <dbReference type="EMBL" id="NNBL01000028">
        <property type="protein sequence ID" value="PJN06545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN06545">
        <property type="protein sequence ID" value="PJN06545"/>
        <property type="gene ID" value="CG723_38225"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008785">
        <property type="term" value="F:alkyl hydroperoxide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032843">
        <property type="term" value="F:hydroperoxide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004601">
        <property type="term" value="F:peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051920">
        <property type="term" value="F:peroxiredoxin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01676">
        <property type="entry name" value="AhpD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004674">
        <property type="entry name" value="AhpD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029032">
        <property type="entry name" value="AhpD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004675">
        <property type="entry name" value="AhpD_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003779">
        <property type="entry name" value="CMD-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02627">
        <property type="entry name" value="CMD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69118">
        <property type="entry name" value="SSF69118"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00777">
        <property type="entry name" value="ahpD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00778">
        <property type="entry name" value="ahpD_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0049">Antioxidant</keyword>
    <keyword evidence="4 6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="1 6" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="5 6" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CMD" evidence="7">
        <location>
            <begin position="94"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="6">
        <location>
            <position position="131"/>
        </location>
    </feature>
    <feature type="active site" description="Cysteine sulfenic acid (-SOH) intermediate" evidence="6">
        <location>
            <position position="134"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="131"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="disulfide bond" description="Interchain (with AhpC); in linked form" evidence="6">
        <location>
            <position position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02627"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PJN06545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="176" mass="18998" checksum="7EBB76D88051BD14" modified="2018-04-25" version="1">MALDELKSAVPDYAKDLRLNLGSVIGNSDLPQQQLWGTVLACAIASRSPRVLRELEPEAKANLSPEAYTAAKSAAAVMAMNNVFYRTRHLLSDPEYGTLRAGLRMNVIGNPGVEKVDFELWSLAVSAINGCGQCLDSHEQVLRKAGVDRETIQEAFKIAAVIQAVGVTLDSEDVLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JI94</accession>
    <name>A0A2M9JI94_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Mycothiol S-conjugate amidase</fullName>
            <ecNumber evidence="2">3.5.1.115</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2 3" type="primary">mca</name>
        <name evidence="3" type="ORF">CG723_38485</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl-inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>H2O + mycothiol S-conjugate = 1D-myo-inositol 2-amino-2-deoxy-alpha-D-glucopyranoside + an N-acetyl-L-cysteine-S-conjugate</text>
            <dbReference type="Rhea" id="RHEA:36543"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:58718"/>
            <dbReference type="ChEBI" id="CHEBI:58886"/>
            <dbReference type="ChEBI" id="CHEBI:59633"/>
            <dbReference type="EC" id="3.5.1.115"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="2">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MshB deacetylase family. Mca subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.115" evidence="2"/>
    <dbReference type="EMBL" id="NNBL01000028">
        <property type="protein sequence ID" value="PJN06588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN06588">
        <property type="protein sequence ID" value="PJN06588"/>
        <property type="gene ID" value="CG723_38485"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010126">
        <property type="term" value="P:mycothiol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010127">
        <property type="term" value="P:mycothiol-dependent detoxification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10320">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01482">
        <property type="entry name" value="Mca"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003737">
        <property type="entry name" value="GlcNAc_PI_deacetylase-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024078">
        <property type="entry name" value="LmbE-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017811">
        <property type="entry name" value="Mca"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12993">
        <property type="entry name" value="PTHR12993"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12993:SF16">
        <property type="entry name" value="PTHR12993:SF16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02585">
        <property type="entry name" value="PIG-L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102588">
        <property type="entry name" value="SSF102588"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03446">
        <property type="entry name" value="mycothiol_Mca"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0862">Zinc</keyword>
    <feature type="binding site" evidence="2">
        <location>
            <position position="13"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="16"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="144"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01482"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN06588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="293" mass="33069" checksum="E18241BDE06A49AE" modified="2018-04-25" version="1">MTEQLRLMAVHAHPDDESSKGAATMAKYVSEGVAVLVVTCTGGERGSILNPKLQGDTYIEENIHEVRKKEMDEARAILGVDQEWLGFVDSGLPEGDPLPPLPEGCFALEDVDKAAGELVRQIRSFRPQVVTTYDENGGYPHPDHIMTHKISMVAFEGAADTEKYPESEYGPAYQPQKLYYNQGFNRPRTEALHQAMLDRGLESPYAEWLKRWDEFERVERTLTTHIPCADFYEIRDKALIAHATQIDPDGGWFRVPMELQRAVWPTEEYELAKSLVDTSLPEDDLFAGIRDNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JIH1</accession>
    <name>A0A2M9JIH1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CG723_37990</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000027">
        <property type="protein sequence ID" value="PJN06670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN06670">
        <property type="protein sequence ID" value="PJN06670"/>
        <property type="gene ID" value="CG723_37990"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PJN06670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="200" mass="22437" checksum="590756A4FC99F125" modified="2018-04-25" version="1">MAGFRSLARQTRDPRNDLALRRYSLRKCLERFAPYGHRATWDHLCSRAGFDPEDRSPEPARLTAALDELEEARAVWLAYETQFAERRRKEKHDGLRRPGTVDDWHRLTWGGFGVAWCDDPMVHPSEPLAEVLNRLIAALEREPGTACPVCTGTALLWKHDLAHEPSSGPVCTHCGIVVPRPVLTPASLAGAWRARVLVSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JIM5</accession>
    <name>A0A2M9JIM5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CG723_37235</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000026">
        <property type="protein sequence ID" value="PJN06728.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN06728">
        <property type="protein sequence ID" value="PJN06728"/>
        <property type="gene ID" value="CG723_37235"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PJN06728.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="309" mass="33374" checksum="90AA0D09FC2FBD79" modified="2018-04-25" version="1">MNTLPEKDLPPGRHRLLKEHLMTEIRETEVPAQAPPRRKWLRPAFAAVAVATAAAVTFVALPSDGAGAPPPTKEAVALLEDVALAAEHSDTPARIRDDQFVYVDSLVSYSQSGEGMKTKIPPLHRLETWQSVDGTRKGLVREKGRGQWATETGPVPGKPGYETSTSYRHLSTLPTDPDAMLRWLRGTGPEHSGQQADQAMFVLVGDLIRDALVPPEVGAALYRAAARIPGVTVVKGVKDAAGRPGIAVARKDPDNPSRDEWIFDVKTHEFLGERTVATEAWSGGVKKGQVTSNTAVVDRAVVDKPGQRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-09-29" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JJ04</accession>
    <name>A0A2M9JJ04_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Acyl-phosphate glycerol 3-phosphate acyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CG723_36775</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000025">
        <property type="protein sequence ID" value="PJN06840.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN06840">
        <property type="protein sequence ID" value="PJN06840"/>
        <property type="gene ID" value="CG723_36775"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007060">
        <property type="entry name" value="FtsL/DivIC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04977">
        <property type="entry name" value="DivIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="44"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="127"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="69"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PJN06840.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="162" mass="18842" checksum="C28DA7BA71019C1B" modified="2018-04-25" version="1">MAGRVRDRDRDRFSTATRLRLLGEQTAERVYRSQTRRQARRSRLTSRAALLALVLCTLVVALAYPIRQYVSQRGEIADLQRQQQEAQSRVDRLRDEKARWQDDSYAEQRIRDRLHLVMPGETGYIARDPDAAKRTRSEQGAAGRPWYSNVWDGVDKADRPDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JJ91</accession>
    <name>A0A2M9JJ91_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">FAD-binding dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CG723_36155</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000024">
        <property type="protein sequence ID" value="PJN06938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN06938">
        <property type="protein sequence ID" value="PJN06938"/>
        <property type="gene ID" value="CG723_36155"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033765">
        <property type="term" value="F:steroid dehydrogenase activity, acting on the CH-CH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008202">
        <property type="term" value="P:steroid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.700.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003953">
        <property type="entry name" value="FAD-binding_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027477">
        <property type="entry name" value="Succ_DH/fumarate_Rdtase_cat_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00890">
        <property type="entry name" value="FAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56425">
        <property type="entry name" value="SSF56425"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD_binding_2" evidence="3">
        <location>
            <begin position="9"/>
            <end position="471"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PJN06938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="498" mass="52264" checksum="B7FC12ECD0E69CA2" modified="2018-04-25" version="1">MTKPPTPTIIVAGAGLSGLCAAVSAREAGARVVLLEKGSRQDVGGNAAFSGGLFLFCYDGPDDLTSITQDFEPGMKADRIEAPPYTRQAYAAELMTMSGGQSQPRLVNALAEQSLDTVRWLAANGVRFTFNRTLGAEVRDGTLHVPPGQILTCAGEGMSRGFEVIRPLLAHAERIGVEIRWSAPLAEVLRSDGRVTGATLGDGGETVPADAVVVATGGFQASGELRREYLGPQWETVRLRGTRLATGDGIQAALRAGAEKAGAWSSCHSAAVDPIMPSPQRSEASPPFPLHGFWLGVLINRDGERFVDEGPGPWVKNYSKMGKAIMTQPGCEAFEIFDQRTAAKVADEFAGAAVPIIARTVPELAERIGVPADRLAHTLETYNNACPPGNDTTEDRGTVGITPPKSRWASPLDRPPFVAYHAVAGLTFTFGGIRIDPDGRALAADGTPVPGLYAAGEAIGGLFYGDYPGGAALMRAAVFGRAAGHTAATETKPVPHPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JJH2</accession>
    <name>A0A2M9JJH2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CG723_36050</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000024">
        <property type="protein sequence ID" value="PJN07014.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN07014">
        <property type="protein sequence ID" value="PJN07014"/>
        <property type="gene ID" value="CG723_36050"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PJN07014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="251" mass="26031" checksum="5806D59967171291" modified="2018-04-25" version="1">MAGRKALVTGGARGIGAAVAHRLAADGADVAINYRSSSDAAQALADEITADGRRAVAIKADVSDPDQIQRLTDEAADALGGLDILASNAGIEHFGKLEAITPADFDRVFAINARGQFFAVQNAVRHMGEGGRIVLTSSGSAHKAVFHHALYASSKAAVECIALNLSPELGRRGININAIAPGGTVTDMSDHAASQYVHPDIDADFHTVIRTASSLGRMAQPAEIAAVVSFLVSDEASFITGRTIQADGGWF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-09-29" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JJJ8</accession>
    <name>A0A2M9JJJ8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DNA polymerase III subunit delta</fullName>
            <ecNumber evidence="3">2.7.7.7</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_35445</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.7" evidence="3"/>
    <dbReference type="EMBL" id="NNBL01000023">
        <property type="protein sequence ID" value="PJN07034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN07034">
        <property type="protein sequence ID" value="PJN07034"/>
        <property type="gene ID" value="CG723_35445"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="283"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="253"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="300"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN07034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="401" mass="42911" checksum="948051DEC0938B3D" modified="2018-04-25" version="1">MPVWDDLVGQERVAAQLDAAARDADALVTANATNAPPPEASRMTHAWLFTGPPGAGRATAARAFAAALQCVSPDRALGGAPGCGFCDGCHTSLVGTHADVEIVRTDLLSIGVKETRELVRRAHLSPAVGRWQVIVLEDADRLTEGAGNVLLKAVEEPAPRTVWLLCAPSLEDVLPTIRSRCRHLTLRTPAVEAVADMLVRRDGIEPAVAAEAARATQGHIDRARRLATDPRARARRAAVLKLPLRVDDIGGCLKAAQELIDTAAEDTKQLAEEVDTKETEELKAALGGQSGGRMPRGTAGAMKELEDRQKRRRTRTQRDSLDLALTDLTGFYRDVLALQLGSRVALANTEAQDTLERLARAASPEATLRRIEAIAACRDALDRNVAPLLAVEAMTMALRAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JJS9</accession>
    <name>A0A2M9JJS9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">AraC family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_36015</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000023">
        <property type="protein sequence ID" value="PJN07131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN07131">
        <property type="protein sequence ID" value="PJN07131"/>
        <property type="gene ID" value="CG723_36015"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002818">
        <property type="entry name" value="DJ-1/PfpI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01965">
        <property type="entry name" value="DJ-1_PfpI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="1">
        <location>
            <begin position="231"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN07131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="338" mass="36879" checksum="4078E526843CF402" modified="2018-04-25" version="1">MPHADPHSPAHPTQRIALLAFPGIRAFDVSVITEVWGTDRTDRGVPAFDLRRVAEDRTPVPMRGGLTLTPDRTLTWLTRLAPATDLLVVPGLDDHLTPAPEPVLESLRRAHARGVTIAALCGGAFTLAQAGLLDGRRAITHWNLVDLLRAHHPLVTVEPDALFIEDDNIWTAAGTAAGIDLCLHLVRRNHGAETAATIARSMVTAPFRTGTQAQFIEHPTPRADRDADALTSVRAYALQHLHEPLTVAGLAARASMSPRSFARHFTAATGTTPLRWLLDQRMAAAQKLLERTDLPMPEVARRAGFGSEVTMRQHFASRLATSPRSYRASFAERPVTHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JJU5</accession>
    <name>A0A2M9JJU5_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">T2SSF domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CG723_35380</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CB01635</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000023">
        <property type="protein sequence ID" value="PJN07134.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN07134">
        <property type="protein sequence ID" value="PJN07134"/>
        <property type="gene ID" value="CG723_35380"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018076">
        <property type="entry name" value="T2SS_GspF_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00482">
        <property type="entry name" value="T2SSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="71"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="222"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="domain" description="T2SSF" evidence="7">
        <location>
            <begin position="121"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00482"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PJN07134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="258" mass="26105" checksum="68299C70DDF8C78F" modified="2018-04-25" version="1">MNVVHRLGLVLCVVTGLGWVVHEVVARRRERALLRRWNALLEAVTEKPAGRGVDVRGAIGRWGPPAGAVCAGYVLVGGVAGLLLGLVAAFGVWRWRRRARAAAGVTASSEAQARRQLPLAADLLAACIAAGADPVRAARAVGESLGGPVGEALARGAAQVRLGGEPRAAWRQLASIPGAGALAGLLERAGDSGAPAAEPVARLAAEARAERGRATTAVARRAAVLITAPVGLCFLPAFVAIGVLPVVIGVAGGLLGGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JJW9</accession>
    <name>A0A2M9JJW9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CG723_35700</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CB01635</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000023">
        <property type="protein sequence ID" value="PJN07077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN07077">
        <property type="protein sequence ID" value="PJN07077"/>
        <property type="gene ID" value="CG723_35700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024320">
        <property type="entry name" value="LPG_synthase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031553">
        <property type="entry name" value="tRNA-synt_2_TM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09924">
        <property type="entry name" value="LPG_synthase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16995">
        <property type="entry name" value="tRNA-synt_2_TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="23"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="64"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="94"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="117"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="148"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="205"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="domain" description="tRNA-synt_2_TM" evidence="10">
        <location>
            <begin position="22"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="domain" description="LPG_synthase_C" evidence="9">
        <location>
            <begin position="245"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="584"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="585"/>
            <end position="615"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF09924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF16995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PJN07077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="621" mass="67358" checksum="D40BD1D42838ABA4" modified="2018-04-25" version="1">MSGGVPGRTRHLRRILRGPRPEAVPVLIARACVLVGLLDVAAGVFPRFRHSRMHALAEVLPGALGPFAAALAISTGVLLLLLGHGLRRHKRRAWRAAVVLLPLGALAQFAYRHSLLGVLIPLVLLTLLLRHGSEFAALPDPRSRWRALANFVLMGAGSIVIGLAIVSAHPKKLVGDPSLSDRLEHVLYGLFGMDGPVDYAGRTSWTVACSLGALGLLTALTTIYLAFRPEHPVARLTADDEARLRALLDKHGARDSLGHFALRRDKGVVFSPSGKAAVCYRVVSGVMLASGDPVGDVEAWPGAIEQFMDEAKAHSWTPAVMGCSETGGEVWTRETGLDALELGDEAVVDTADFSLAGRAMRNVRQMVKRIERNGYETRVRRIRDLGDQELERIRRAADDWRGTDTERGFSMALGRIGDAADGDCLVATAHKADGPAGPHGDLKAVLHFVPWGTDGVSLDLMRRDRAADPGMNELLIVAALQAAPKLGITRISLNFAMFRAALARGDKIGAGPVLRAWRGLLVFLSRWFQIESLYRFNAKFRPRWEPRFVVYRSSRDLPRIGFAAMQAEGFVNLAMPRLLRRRRAGPRPCAHDAGHDAGHDGSHGGSHDDSHDGGRRGAQAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JK18</accession>
    <name>A0A2M9JK18_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Gamma carbonic anhydrase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CG723_35070</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000022">
        <property type="protein sequence ID" value="PJN07213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN07213">
        <property type="protein sequence ID" value="PJN07213"/>
        <property type="gene ID" value="CG723_35070"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001451">
        <property type="entry name" value="Hexapep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00132">
        <property type="entry name" value="Hexapep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="SSF51161"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PJN07213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="177" mass="17950" checksum="18285E7BF68D9AD2" modified="2018-04-25" version="1">MGQQALITGIGGKDPELDEEAFAAPTSVVIGEVTLHAGASVWYGAVLRADCGPIVLGADSNIQDNCTVHVDPGFPVTVGERVSVGHNAVLHGCTVEDDCLVGMGATVLNGAVIGAGSLVAAQALVPQGMQVPPGSLVAGVPAKVKRPLTEEERAGITLNGTLYVELAKAHRAAHEDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JK26</accession>
    <name>A0A2M9JK26_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DNA alkylation repair protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CG723_35120</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000022">
        <property type="protein sequence ID" value="PJN07223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN07223">
        <property type="protein sequence ID" value="PJN07223"/>
        <property type="gene ID" value="CG723_35120"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014825">
        <property type="entry name" value="DNA_alkylation"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08713">
        <property type="entry name" value="DNA_alkylation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="SSF48371"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PJN07223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="234" mass="26419" checksum="1F0638EAEB50CFF6" modified="2018-04-25" version="1">MTVTVPRSAPADTLLERLTSVYPTAADPERAGQMRAYMKDVAPFLGLTTPVRRALSRTVLAGAPRPNEADCTALALRCWELPEREYAYFAVDYLRRYVGRCSSGFLPVARHLVSTVPWWDTVDLLAAHVVGALVAADPRLEKDMDAWIEDDDLWIARTALLHQLRRKETTDTERLFGYCLRQAPHPDFFIRKAIGWCLREYAKTDPDAVRSFVAAHRDRLAPLSVREALKNIGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JK53</accession>
    <name>A0A2M9JK53_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CG723_34800</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000022">
        <property type="protein sequence ID" value="PJN07167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN07167">
        <property type="protein sequence ID" value="PJN07167"/>
        <property type="gene ID" value="CG723_34800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PJN07167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="119" mass="12983" checksum="DD2CCD3807DE0B85" modified="2018-04-25" version="1">MEQSEIILRAIGVLTETQEMVRRLSEDAEPDIETEDAQLGRLVTEAFPSIEIPAESSVEEAAEATIAALMPVTISLVGAFAFLFSELAEVHDSGRTDIKSADLLQHLALRLSRTDDGDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JKA0</accession>
    <name>A0A2M9JKA0_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">3-dehydroquinate synthase</fullName>
            <shortName evidence="8">DHQS</shortName>
            <ecNumber evidence="8">4.2.3.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">aroB</name>
        <name evidence="10" type="ORF">CG723_34120</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CB01635</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>7-phospho-2-dehydro-3-deoxy-D-arabino-heptonate = 3-dehydroquinate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:21968"/>
            <dbReference type="ChEBI" id="CHEBI:32364"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58394"/>
            <dbReference type="EC" id="4.2.3.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
        <cofactor evidence="8">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="8">Binds 1 divalent metal cation per subunit. Can use either Co(2+) or Zn(2+).</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="8">Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 2/7.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the sugar phosphate cyclases superfamily. Dehydroquinate synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.3.4" evidence="8"/>
    <dbReference type="EMBL" id="NNBL01000021">
        <property type="protein sequence ID" value="PJN07292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN07292">
        <property type="protein sequence ID" value="PJN07292"/>
        <property type="gene ID" value="CG723_34120"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00053">
        <property type="reaction ID" value="UER00085"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003856">
        <property type="term" value="F:3-dehydroquinate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009073">
        <property type="term" value="P:aromatic amino acid family biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008652">
        <property type="term" value="P:cellular amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009423">
        <property type="term" value="P:chorismate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00110">
        <property type="entry name" value="DHQ_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016037">
        <property type="entry name" value="DHQ_synth_AroB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030963">
        <property type="entry name" value="DHQ_synth_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030960">
        <property type="entry name" value="DHQS/DOIS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01761">
        <property type="entry name" value="DHQ_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001455">
        <property type="entry name" value="DHQ_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01357">
        <property type="entry name" value="aroB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="7 8" id="KW-0170">Cobalt</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 8" id="KW-0456">Lyase</keyword>
    <keyword evidence="2 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 8" id="KW-0520">NAD</keyword>
    <keyword evidence="3 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="DHQ_synthase" evidence="9">
        <location>
            <begin position="72"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="110"/>
            <end position="114"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="134"/>
            <end position="135"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="147"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="156"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="189"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="252"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="268"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PJN07292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="364" mass="38493" checksum="1E2E5A4F2465A229" modified="2018-04-25" version="1">MTEQQVTRIQVGGTAGTDPYEVLVGRQLLGELGGLIGDSAQRVAIIHPEALAETGEALRGDLADQGFEVVAIQVPNAEEAKTAEVAAYCWKALGQSGFTRTDVIVGVGGGATTDLAGFVAATWLRGVRWIAVPTTVLGMVDAAVGGKTGINTAEGKNLVGSFHPPAGVLCDLAALDSLPVNDFVSGLAEIIKAGFIADPAILDLIESDPEAARSPQGPHTAELIERSIKVKAEVVSGDLKESGLREILNYGHTLAHAIEKNERYKWRHGAAVSVGMHFAAELGRLAGRLDDATADRHRTVLESVGLPLSYRYDQWPKLLENMKVDKKSRGNLLRFIVLDGLAKPTVLEGPDPAVLLAAYGEVAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JKP5</accession>
    <name>A0A2M9JKP5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Sugar phosphate isomerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_33640</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000020">
        <property type="protein sequence ID" value="PJN07444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN07444">
        <property type="protein sequence ID" value="PJN07444"/>
        <property type="gene ID" value="CG723_33640"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036237">
        <property type="entry name" value="Xyl_isomerase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013022">
        <property type="entry name" value="Xyl_isomerase-like_TIM-brl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01261">
        <property type="entry name" value="AP_endonuc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51658">
        <property type="entry name" value="SSF51658"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AP_endonuc_2" evidence="1">
        <location>
            <begin position="20"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN07444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="306" mass="34308" checksum="022FE86748DF9591" modified="2018-04-25" version="1">MKLGMLTACLPDASLDDIAAWAAKTGYEALEVAVWPRTGGRDFEAAHLPAADFGTRERDDTLALLDRHGLSISALAYYENNLHPDPERRAAIRTHLKRAIDAAAALGVPYVGTFVGRDWTRPVAENLAEAERILPELVEYAGERDVRIVIENCVMEGWHPDGYPGNLAYSPELWEWMFDLGLYLNWDPSHLTWIGIDPVTTIAPYADRIVHAQAKDIEIQAGRIDRYGFFGKATGRKDPWDTGWWRYRVPGRGQVDWNAVVDALYEHGFTGTLSVEHEDPVWGGTPDRVRQGLEIAHRSLRPLLIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JKT8</accession>
    <name>A0A2M9JKT8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GNAT family N-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_33945</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000020">
        <property type="protein sequence ID" value="PJN07491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN07491">
        <property type="protein sequence ID" value="PJN07491"/>
        <property type="gene ID" value="CG723_33945"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="157"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN07491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="296" mass="31922" checksum="A14BD244140F2BDF" modified="2018-04-25" version="1">MSLNLTPLTDPSGGPDGRRLAWLASDTDGNPVGSAFLRLIDRDGQRHLAQLALQVHPAERRRGAGTRLLDAAVTAAKDDGRRSLTAPADDGSPADLFLAARGFRRVLNLTYARLPLAEADVPALTRTARAEHPGYRLVSWEGTVPDHLAATFAASRRAMDDMPMDDTDYGTVAWDVDRVRAVAKAVEERGEHLDTVVAVDASDGTVVGFTELVVPGDGTGDGQHYGTGVLPEHRGHGLARWMKAEAVLRARGRHPKLGGLLTDTADSNTHMRAVNDGLGYLPTHRTYEYQLELQQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JL44</accession>
    <name>A0A2M9JL44_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">SsgA family sporulation/cell division regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CG723_32955</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CB01635</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell septum</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SsgA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000019">
        <property type="protein sequence ID" value="PJN07578.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN07578">
        <property type="protein sequence ID" value="PJN07578"/>
        <property type="gene ID" value="CG723_32955"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030428">
        <property type="term" value="C:cell septum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030435">
        <property type="term" value="P:sporulation resulting in formation of a cellular spore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.31.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006776">
        <property type="entry name" value="SsgB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038658">
        <property type="entry name" value="SsgB_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04686">
        <property type="entry name" value="SsgA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4" id="KW-0132">Cell division</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0749">Sporulation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PJN07578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="153" mass="16580" checksum="3179649ABD6A97C7" modified="2018-04-25" version="1">MRESVQAVQAEVMMSFLVSEELSFRIPVELRYAAADPYAVRLTFHLPGDAPVTWAFGRELLVDGVAGPCGDGDVRIEPVELAGRPGEMPGEVHIRLQVGGDQALFRAGVAPLVAFLDRTDKLVPLGQERALADFEAHLDEALDRILAEEQSAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JLJ1</accession>
    <name>A0A2M9JLJ1_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF1918 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_32285</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000018">
        <property type="protein sequence ID" value="PJN07750.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN07750">
        <property type="protein sequence ID" value="PJN07750"/>
        <property type="gene ID" value="CG723_32285"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015035">
        <property type="entry name" value="DUF1918"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08940">
        <property type="entry name" value="DUF1918"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF1918" evidence="1">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN07750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="64" mass="7105" checksum="FCECBCD9CF883DD9" modified="2018-04-25" version="1">MRATKGDHLRVHGRTVGEHDRVAEIVEIMGHDGEPPFRVRFQDGHEAVMSPGPDSVVQHEEPAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JLP3</accession>
    <name>A0A2M9JLP3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Glycine/betaine ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CG723_32445</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CB01635</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000018">
        <property type="protein sequence ID" value="PJN07779.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN07779">
        <property type="protein sequence ID" value="PJN07779"/>
        <property type="gene ID" value="CG723_32445"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007210">
        <property type="entry name" value="ABC_Gly_betaine_transp_sub-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04069">
        <property type="entry name" value="OpuAC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="49"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="90"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="134"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="201"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="239"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="299"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="87"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PJN07779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="872" mass="95136" checksum="AA4E4EFD36440927" modified="2018-04-25" version="1">MPRIPFGDWVNDVVEWLLSNAAWLFDFFKNVFNGAYDGINWVLQAPQPLILAGIFAVIAFWLRGTVAGVLTFVGFAFIDSLELWDHAMMTLSLVLVATIIALVISVPVGIWASRSNRVSAVVRPVLDFMQTLPAMIYLIPAILFFGSGAPAGIVATLIFALAPGVRMTELGIRQVDKELVEAADAFGDTPRNTLFRVQLPLALPSIMAGVNQVIMLGLSMAAIAGMVGSEGLGADVNEAIGQLNIGLGSESGVAIVILAIYLDRMTSALGTQSSPMGRRALAKVRAAHGLTVWNYRPQAAVAVVGVVILALVAGGMGIFGGSKSENPVADASDVGQGKKISIGYIPWDEGVASTFLWKEILEQRGFDVQVKQLEAGPLYTSLASGQIDFETDSWLPTTHAQYWKKYGKQLDDMGSWYGPTSLELSVPAYMKGIDSLEDLKGKSGTFGGKITGIESSAGMMGILKDKVLKEYGLDKEYKVVDSSTPAMLAQLKRAYAKKQPIVTTLWSPHWAYSDYKLKKLKDPKGAWGKGDGVHTLSRKGFADDNPEVGKWLKNFNMTEKQLTSLEAEINKAGKGKQQDAVKTWLKSNPGVVDKLAPVKKSSTAGGKGEAARPVNVAWFPWDEDVAVTYLWKRVLGDRGYKLNLKQMDVGPVYTGLGSGDLDVNFDAWLPYAQKNYWDKHKDNLIDLGSWYSPTSLEIAVPSYVKGVKSLEDLKGKGSTFDGKIIGIEPGTGEMNLLKKNVLPGYGLDKEYKVVDGSTPAMLAELKRAYAKKQPVAVVLWSPHWAYSEYKLNKLTDSKKLFGEGNTIRTIANKSFPSKYPQLTKWFKNFKLSESELGSLEAEIKKRGQGHEEEAVDAWLKTHKGVADRMAPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-09-29" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JLS2</accession>
    <name>A0A2M9JLS2_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Protein translocase subunit SecD</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9 11" type="primary">secD</name>
        <name evidence="11" type="ORF">CG723_31885</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CB01635</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Forms a complex with SecF. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF. Other proteins may also be involved.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cell membrane</location>
            <topology evidence="9">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the SecD/SecF family. SecD subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000018">
        <property type="protein sequence ID" value="PJN07818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN07818">
        <property type="protein sequence ID" value="PJN07818"/>
        <property type="gene ID" value="CG723_31885"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015450">
        <property type="term" value="F:protein-transporting ATPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0065002">
        <property type="term" value="P:intracellular protein transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006605">
        <property type="term" value="P:protein targeting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043952">
        <property type="term" value="P:protein transport by the Sec complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01463_B">
        <property type="entry name" value="SecD_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005791">
        <property type="entry name" value="SecD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022813">
        <property type="entry name" value="SecD/SecF_arch_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022645">
        <property type="entry name" value="SecD/SecF_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022646">
        <property type="entry name" value="SecD/SecF_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30081">
        <property type="entry name" value="PTHR30081"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07549">
        <property type="entry name" value="Sec_GG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02355">
        <property type="entry name" value="SecD_SecF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00916">
        <property type="entry name" value="2A0604s01"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01129">
        <property type="entry name" value="secD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 9" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 9" id="KW-0811">Translocation</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="391"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="418"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="448"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="497"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="522"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="136"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="243"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="563"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="165"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01463"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PJN07818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="593" mass="61480" checksum="60CAF57EF657248D" modified="2018-04-25" version="1">MAAPKKGRSHGAQSRPGRTLAFILIAMVALTGGMFLSGHTTPRLGIDLAGGTSITLKAKSEPGQKNAVNQTNMNTAVSIIERRVNGLGVTESEVQTQGSDNIIVNIPKGTNEAQAREQVGTTAQLYFRPVLTVAAGAPTPEPSASPSGSDKGKATDKATDKATDGGNGKASSTPTASPTSSATSQGRAVTDGLKADSSPSPSASASASGKPTPSASSTPDPATAALQKKFTDLNCTDKAARSQVASGVKPEDPAVACGKNSSGQWEKYVLGPAEVNGKDVDKAQATINQQTGAWVVNMDFTGGGSKKFAKITSKLSQQQPPMNQFAIVLDGDVVSAPSVSSTLSGSAEISGSFDQQSAQDLANVLSYGALPLSFQEQSVTTVTAALGGEQLHAGLIAGAIGLLLVVIYLVVYYRGLSLIALASLMVSAILTYVIMTLLGPAIGFALNLPAVCGAIVAIGITADSFIVFFERIRDEIREGRSLRPSVERAWPRARRTILVSDFVSFLAAAVLFVVTVGKVQGFAFTLGLTTVLDVVVVFLFTKPLMTILARKKFFASGHPWSGLDPKRLGAKPPLRRTRRAPGSPVGPVDTKEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JMA9</accession>
    <name>A0A2M9JMA9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Glycosyl hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CG723_30390</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CB01635</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the glycosyl hydrolase 3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000016">
        <property type="protein sequence ID" value="PJN08006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08006">
        <property type="protein sequence ID" value="PJN08006"/>
        <property type="gene ID" value="CG723_30390"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1700">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026891">
        <property type="entry name" value="Fn3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019800">
        <property type="entry name" value="Glyco_hydro_3_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002772">
        <property type="entry name" value="Glyco_hydro_3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036881">
        <property type="entry name" value="Glyco_hydro_3_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001764">
        <property type="entry name" value="Glyco_hydro_3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036962">
        <property type="entry name" value="Glyco_hydro_3_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14310">
        <property type="entry name" value="Fn3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00933">
        <property type="entry name" value="Glyco_hydro_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01915">
        <property type="entry name" value="Glyco_hydro_3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00133">
        <property type="entry name" value="GLHYDRLASE3"/>
    </dbReference>
    <dbReference type="SMART" id="SM01217">
        <property type="entry name" value="Fn3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52279">
        <property type="entry name" value="SSF52279"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00775">
        <property type="entry name" value="GLYCOSYL_HYDROL_F3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fn3_like" evidence="4">
        <location>
            <begin position="636"/>
            <end position="707"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU361161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM01217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PJN08006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="718" mass="75903" checksum="C9095B6567B07DB5" modified="2018-04-25" version="1">MLRGYEDQVKGLLDQMTTAEKLGQLQQLTWTGDTGPGGGQTAHIEAAARAGLLGSVLNIHGAAHTNALQRMAVEESRLGIPLLFGLDVIHGFWTTFPIPLAQAASFDPEVARRDAEVSAAETRSNGVRWTFSPMMDVTHEPRWGRIAEGCGEDPYVNAAFAVAKVRGYQGSDGGGELADGERIAACAKHFVAYGGAEGGRDYNTVDVSEQRLRNHYLPPFKAAVDAGVATVMAAFNTVAGVPAHGNPHTMNAILKEEWGFDGFVVSDYTGVEELIAHGFAEDGADAARLAFNAGLDMEMVSTNVTEHGEQLVADGLIGETRLDDAVTRILRLKFALGLFDQPYTDEPAEITGPTPAAREAARAAGARSMVLLKNDDGLLPLERTTPSIAVVGPLASSTDLHGTWAGPGGFHLPSVSIVDAVRTAAPDARIIHADDDITAAVAAAQEAEITVVVVGEPPALSGEASVRSDIGLPSGQEELIAAVAATGKPYAVVLLNGRPLTIGDWLDTAPAVLEAWHPGIEAGHAVADVLFGTVNPGGKLPVSFPRAVGQIPVYYNHENTGRPAHVLGADPKFVSKYLDLEETPQLPFGHGLSYTTFTTGAPELRRAEITRDELAAGETLEVTVTVTNTGDCVGDEVVQLYIHDVAASIAQPVRRLRGFERVTLEPGGSTTVRFRLGADDLGFWTNDPAGTYVVERGRVDVYAGTSSTAEARCTLHIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JMB3</accession>
    <name>A0A2M9JMB3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Glycosidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CG723_30440</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CB01635</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyl hydrolase 130 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000016">
        <property type="protein sequence ID" value="PJN08015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08015">
        <property type="protein sequence ID" value="PJN08015"/>
        <property type="gene ID" value="CG723_30440"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016798">
        <property type="term" value="F:hydrolase activity, acting on glycosyl bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008152">
        <property type="term" value="P:metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.115.10.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023296">
        <property type="entry name" value="Glyco_hydro_beta-prop_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007184">
        <property type="entry name" value="Mannoside_phosphorylase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34106">
        <property type="entry name" value="PTHR34106"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04041">
        <property type="entry name" value="Glyco_hydro_130"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75005">
        <property type="entry name" value="SSF75005"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="1" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00024356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PJN08015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="359" mass="38962" checksum="C4802EFC5336F6F4" modified="2018-04-25" version="1">MSNTTVATDIPYRMVRKGVVMSPLAGEANEVEGVLNPASGRTPDGTLHLLPRLVAEGNVSRVGLAEVTFDETGVPGAVERRGVVLSPDEGWERGKNNAGVEDPRITWVPSLGKHVMSYVAYGPLGPKPALAVSENLTDWTRLGPVQFQYQADLDTDLNLFPNKDVVHFPEPVPGPDGEMAYAMLHRPMWDLGWFRPGEGVHLPAGVTDERPGIWISYVPVAEVEADIRALTRPRDHRLLALSEFPWESLKIGGGPAPIRVPEGWLLIHHGVSGSIEDPWAQNQKVSYAAGAMILDPADPSKVLARSDKPLMAPETEEEISGTVPNVVFPTAIEEIDGKLYVFYGMADAHIGVALLERTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JMT3</accession>
    <name>A0A2M9JMT3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Sulfate ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CG723_29705</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000015">
        <property type="protein sequence ID" value="PJN08182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08182">
        <property type="protein sequence ID" value="PJN08182"/>
        <property type="gene ID" value="CG723_29705"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="11"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="43"/>
            <end position="50"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PJN08182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="306" mass="32379" checksum="A97316ADBF1E9B02" modified="2018-04-25" version="1">MTTTAQATEVVGFEQVSKSYGDVRAVDGLTLELHPGETVALLGPNGAGKSTTLDLLLGLRPADTGTVRVFGTSPRDAIVQGRVGAMLQSGGLMDEVTVAELVKLACALHPKPFKPGEVLSRAGITQIADRKVNKLSGGQEQRVRFALATAGANDLIVLDEPTTGMDVSARQAFWATMREQADQGRTVLFATHYLEEADAIADRVLVLHRGRLLADGTAAEIKAKAGARKVAFDLEGDIDEPALRALPFLTTFDVSGRTVRLQSSDADATVHALYGLGVYPRNLEVAGLGLEQAFVAITTAEEARTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JMU8</accession>
    <name>A0A2M9JMU8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Heavy metal transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_29750</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000015">
        <property type="protein sequence ID" value="PJN08190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08190">
        <property type="protein sequence ID" value="PJN08190"/>
        <property type="gene ID" value="CG723_29750"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN08190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="308" mass="32171" checksum="85D5788133A2252C" modified="2018-04-25" version="1">MPEPPTLVRRGRLLRIGAAVVVLLAVAAYLIVQYVSGGRPAPRCTVVSGNGDGASYEFTSEQAVNAATISAVGTSRGMPERAVTIALATALQESGLRNIHHGDRDSLGLFQQRPSEGWGTQAQIMDPVYAAGRFYEHLDKIPGYSRLPLTVAAQRVQRSGYPQAYAKHEPDATLLAAALTGRAGASLTCEGRPSGTEVRKPGEPAKVRAALMRDFGREVSPAAGASGHDVTVPVPATVDSAEGGERQRGWELAHWAVANSSALRIERVSYAGRDWIAGDAGGKWSGAAAQAAAGAGKGLGEVRIVTAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JMX8</accession>
    <name>A0A2M9JMX8_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF3152 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_29920</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000015">
        <property type="protein sequence ID" value="PJN08221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08221">
        <property type="protein sequence ID" value="PJN08221"/>
        <property type="gene ID" value="CG723_29920"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022603">
        <property type="entry name" value="DUF3152"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11350">
        <property type="entry name" value="DUF3152"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF3152" evidence="2">
        <location>
            <begin position="326"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="268"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF11350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN08221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="509" mass="53674" checksum="B144714A7A889F8E" modified="2018-04-25" version="1">MDDAEAVAAGRGRRRRGAPDVPRPTTPGPQAQQGAPRGQAQPGPAPYRGAPPNAGPPRGFSEATPAHGFPQATPPHGFPQATPPRGFQQAAPPQGPTSRGFSEATPAHGFPQATPPHGFPAQGTPAQGSPRVTPSHGFPQGTPAHGVPHVRGGHPEQFEGGARGETRMGVGYAAAPVVPAPRSRPRQDYVDAFAQPPRTPQPRHPSDPYADVTDWDAKGGEPDEAAAGSAEDEEPGDKRRKGRTYTGIAAAAVTTVLAVVVAGHVAQGRDDKAHAQAQPAGGPDKRSTKGSASRSDDRATPGGKARPVIPLTYDQKMGKTYPLSAKLKGSGKFTAVPGFDKAPGKGQKFRYRIDVENGLGLDGGLFAQAVQKTLNDDRSWAHDGGRTFERISSGKPDFVITLASPGTTGVWCEKSGLDTTEDNVSCDSAATDRVMINAYRWAQGSTTYGNKIHLYRQMLINHEVGHRLGFNHVTCTKNGALAPVMQQQTKFLTFDGITCKPNPWAFPKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JN30</accession>
    <name>A0A2M9JN30_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Acetyl-coenzyme A synthetase</fullName>
            <shortName evidence="5">AcCoA synthetase</shortName>
            <shortName evidence="5">Acs</shortName>
            <ecNumber evidence="5">6.2.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Acetate--CoA ligase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">Acyl-activating enzyme</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">acs</name>
        <name evidence="5" type="synonym">acsA</name>
        <name evidence="9" type="ORF">CG723_28130</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CB01635</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>acetate + ATP + CoA = acetyl-CoA + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:23176"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.2.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="PTM">
        <text evidence="5">Acetylated. Deacetylation by the SIR2-homolog deacetylase activates the enzyme.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.2.1.1" evidence="5"/>
    <dbReference type="EMBL" id="NNBL01000014">
        <property type="protein sequence ID" value="PJN08276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08276">
        <property type="protein sequence ID" value="PJN08276"/>
        <property type="gene ID" value="CG723_28130"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003987">
        <property type="term" value="F:acetate-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016208">
        <property type="term" value="F:AMP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019427">
        <property type="term" value="P:acetyl-CoA biosynthetic process from acetate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01123">
        <property type="entry name" value="Ac_CoA_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011904">
        <property type="entry name" value="Ac_CoA_lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032387">
        <property type="entry name" value="ACAS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16177">
        <property type="entry name" value="ACAS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02188">
        <property type="entry name" value="Ac_CoA_lig_AcsA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0007">Acetylation</keyword>
    <keyword evidence="3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 5 9" id="KW-0436">Ligase</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ACAS_N" evidence="8">
        <location>
            <begin position="45"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding" evidence="6">
        <location>
            <begin position="104"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding_C" evidence="7">
        <location>
            <begin position="546"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="region of interest" description="Coenzyme A binding" evidence="5">
        <location>
            <begin position="207"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="326"/>
        </location>
        <ligand>
            <name>CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="402"/>
            <end position="404"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="426"/>
            <end position="431"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="515"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="530"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="538"/>
        </location>
        <ligand>
            <name>CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="552"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="554"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="557"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="modified residue" description="N6-acetyllysine" evidence="5">
        <location>
            <position position="625"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF16177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PJN08276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="666" mass="72481" checksum="02C3065E0734BE3F" modified="2018-04-25" version="1">MVWDTTDTLGKGDVVSNESLANLLKEERRFAPPADLAAAANVTAEAYEQAKADRLGFWAEQARRLTWATEPTETLDWSNPPFAKWFADGKLNVAYNCVDRHVEAGNGDRVAIHFEGEPGDSRAITYAELKDEVSRAANALTELGVQKGDRVAVYLPMIPEAVVAMLACARIGAAHSVVFGGFSADAIAARIRDADAKVVITADGGYRRGKPSALKPAVDDAVSRVDGVEKVLVVQRTKQDVAWTEGRDVWWHEITQKQSAEHTPEAFDAEQPLFILYTSGTTGKPKGILHTSGGYLTQASYTHHAVFDLKPETDVYWCTADIGWVTGHSYITYGPLSNGATQVIYEGTPDTPHQGRFWEIVQKYGVTILYTAPTAIRTFMKWGDDIPAKFDLSSLRVLGSVGEPINPEAWMWYRKNIGGDKCPIVDTWWQTETGAMMISPLPGVTETKPGSAQRALPGISATVVDDEAHEVPNGGGGYLVLTEPWPSMLRTIWGDDQRFIDTYWSRFEGKYFAGDGAKKDEDGDIWLLGRVDDVMLVSGHNISTTEVESALVSHPSVAEAAVVGAADETTGQAIVAFVILRGTANADDEGLVADLRNHVGATLGPIAKPKRVLPVAELPKTRSGKIMRRLLRDVAENRELGDVTTLTDSSVMDLIQTRLPAASSED</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JND3</accession>
    <name>A0A2M9JND3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_28745</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000014">
        <property type="protein sequence ID" value="PJN08375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08375">
        <property type="protein sequence ID" value="PJN08375"/>
        <property type="gene ID" value="CG723_28745"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="48"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN08375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="102" mass="10833" checksum="B94DFF97BD8170C9" modified="2018-04-25" version="1">MRTSTTDIETGLVDLSRWGLQEAMALRDPLVAAAQNALLEHLTEDAVGQVVGGGDGNPYFSPRQHVGTAPQEPRHEHGPPEPPEPASPCDLSDEPDCPALPC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JNK3</accession>
    <name>A0A2M9JNK3_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex</fullName>
            <ecNumber evidence="4">2.3.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CG723_29175</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CB01635</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 4">
            <name>(R)-lipoate</name>
            <dbReference type="ChEBI" id="CHEBI:83088"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the 2-oxoacid dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.-" evidence="4"/>
    <dbReference type="EMBL" id="NNBL01000014">
        <property type="protein sequence ID" value="PJN08448.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08448">
        <property type="protein sequence ID" value="PJN08448"/>
        <property type="gene ID" value="CG723_29175"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.320.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003016">
        <property type="entry name" value="2-oxoA_DH_lipoyl-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001078">
        <property type="entry name" value="2-oxoacid_DH_actylTfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000089">
        <property type="entry name" value="Biotin_lipoyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036625">
        <property type="entry name" value="E3-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004167">
        <property type="entry name" value="PSBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011053">
        <property type="entry name" value="Single_hybrid_motif"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00198">
        <property type="entry name" value="2-oxoacid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00364">
        <property type="entry name" value="Biotin_lipoyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02817">
        <property type="entry name" value="E3_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47005">
        <property type="entry name" value="SSF47005"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51230">
        <property type="entry name" value="SSF51230"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50968">
        <property type="entry name" value="BIOTINYL_LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00189">
        <property type="entry name" value="LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51826">
        <property type="entry name" value="PSBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="3 4" id="KW-0450">Lipoyl</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Lipoyl-binding" evidence="6">
        <location>
            <begin position="9"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="domain" description="Peripheral subunit-binding (PSBD)" evidence="7">
        <location>
            <begin position="164"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="96"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001938"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PJN08448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="465" mass="48387" checksum="E9256CCFC154E28F" modified="2018-04-25" version="1">MTTMTDAALAEFKMPDVGEGLTEAEILKWYVQPGDAVTDGQVVCEVETAKAAVELPIPFNGVVRELRFPEGTTVDVGQVIIAVDVAGGSGSAAAAPAAVSVPEPTAPEPEAEPKGRQPVLVGYGVSEASTKRRPRKGDVVAAPAAVTEPALEPQAPAKGNGRPLAKPPVRKLAKDLGVDLASLTPSGPDGVITREDVHAAVAPAPEPVVTQAQVLAQPQEPVAAAPAVVQDGVRETRIPVKGVRKATAAAMVGSAFTAPHVTEFVTVDVTRTMKLVEELKADKEMQGLRVNPLLLIAKALLVAIKRNPEISASWDEAAQEIVRKHYVNLGIAAATPRGLIVPNIKDAHAKTLPELATALGELVSTAREGKTSPGAMQGGTVTITNVGVFGVDTGTPILNPGEPAILAVGAIKLQPWVHKGKVKPRQVTTLALSFDHRLVDGELGSKVLADVAAILEQPKRLITWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JNM9</accession>
    <name>A0A2M9JNM9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Amidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_28995</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000014">
        <property type="protein sequence ID" value="PJN08417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08417">
        <property type="protein sequence ID" value="PJN08417"/>
        <property type="gene ID" value="CG723_28995"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1300.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000120">
        <property type="entry name" value="Amidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023631">
        <property type="entry name" value="Amidase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036928">
        <property type="entry name" value="AS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11895">
        <property type="entry name" value="PTHR11895"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01425">
        <property type="entry name" value="Amidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75304">
        <property type="entry name" value="SSF75304"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidase" evidence="2">
        <location>
            <begin position="31"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="456"/>
            <end position="476"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN08417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="524" mass="53390" checksum="015628C4A8D81F8D" modified="2018-04-25" version="1">MERRMSCMEQSFETLSGAVHALRTGAVSSRELVTAALADADALDPLLGVFVTRFPEQALATARAADALPAGERGPLHGVPVAVKDNFAAVEGPVTAQSPAHDPGLWRGLDAPAVTRLRSAGAVVIGKTTMAEYAMGRPDPAHSFPVPRNPWDVERWTGGSSTGNGAGIAAGIFLGALGTDTSGSVRLPAALCGTTGLKPTHGLVPLDRCLPLSPSQDVAGPMAVSAADCGLLLSALTGGSYAPRGVGEAGVRGLRIGVPYGLVDAPGITGACRSAFAEALRVLTELGAETREFELPEFSSLLAVNATVMLGEAFVAHGARLAARWELHGRAFRRLAAAGAALGPGLVDGARLTGAALTAGLLERMDGPGGVDVIATPTWPAGARPYAQEAAPGDELNLTAPWNATGFPALALPMGADGAGLPLSLQLVARPHAERTLLGAGAAYQRATAWHLRRATPDPAACPRPLPEPPSTEAARETADDLVTAALNAAGLTPDPADLTAVRATAHALLKSAHELAQAHPEPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-09-29" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JNN6</accession>
    <name>A0A2M9JNN6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Crp/Fnr family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CG723_28170</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000014">
        <property type="protein sequence ID" value="PJN08479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08479">
        <property type="protein sequence ID" value="PJN08479"/>
        <property type="gene ID" value="CG723_28170"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00038">
        <property type="entry name" value="CAP_ED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018490">
        <property type="entry name" value="cNMP-bd-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018488">
        <property type="entry name" value="cNMP-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000595">
        <property type="entry name" value="cNMP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012318">
        <property type="entry name" value="HTH_CRP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00027">
        <property type="entry name" value="cNMP_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13545">
        <property type="entry name" value="HTH_Crp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00100">
        <property type="entry name" value="cNMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00419">
        <property type="entry name" value="HTH_CRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51206">
        <property type="entry name" value="SSF51206"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00889">
        <property type="entry name" value="CNMP_BINDING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50042">
        <property type="entry name" value="CNMP_BINDING_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51063">
        <property type="entry name" value="HTH_CRP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="2">
        <location>
            <begin position="10"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="domain" description="HTH crp-type" evidence="3">
        <location>
            <begin position="144"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PJN08479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="224" mass="24485" checksum="6CAC484BEDA14BE8" modified="2018-04-25" version="1">MDDVLRRAPLFAALDDEQAAELRASMSEVTLARGDALFHEGDPGDRLYVVTEGKVKLHRTSPDGRENMLAVLGPGELIGELSLFDPGPRTATASALTEVKLLGLGHGDLLPWLNARPEVASALLRAVARRLRKTNDQMSDLVFSDVPGRVARALLDLSRRFGVQSEEGIHVVHDLTQEELAQLVGASRETVNKALADFAGRGWLRLEARAVILLDVERLAKRSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-09-29" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JNU7</accession>
    <name>A0A2M9JNU7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CG723_27605</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CB01635</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000013">
        <property type="protein sequence ID" value="PJN08546.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08546">
        <property type="protein sequence ID" value="PJN08546"/>
        <property type="gene ID" value="CG723_27605"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010290">
        <property type="entry name" value="TM_effector"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05977">
        <property type="entry name" value="MFS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="172"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="228"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="264"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="295"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="378"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="7">
        <location>
            <begin position="223"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="408"/>
            <end position="432"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PJN08546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="432" mass="44241" checksum="8EE64ADD29C9BC3D" modified="2018-04-25" version="1">MAPRTPRFAYGYGRLWAATAASGFGDGTRTAALAVYAATLTHDPFAVALVAMAGKLPWTCVGPFAGALVDRLDRWRTLWICDVARVLVTGALVLLILTDRAGITVLAVISFLLTSITTLAENLSQAIVPDVAGGGSLDSANSRLMGGQLVSSEFLGAPLGTALFALGRPVPFAVDTLSFAVSAVLVFSIRLSGARPAPTAAGRLTARAVVSETADGIRWLWRHRVLRTVCVLVGALNFAVVAVLSIAVLYALNVLHISQRAYGLLLAVLAVGGLAGVLLAPLVTRAIGRARTLQLAFALCPLPFLIAGLTSLPLLAAGALAFVGAAISLATVVTTSLRQSLVPGELFGRVNGGYRFVVNGVSPLGGVAGGALAEAAGLRAPFLFAAALLAAATVTALLRLSPAALDAAGDDRPAPRTGQAVAAERTEAPERT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JPF0</accession>
    <name>A0A2M9JPF0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GNAT family N-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_26580</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000012">
        <property type="protein sequence ID" value="PJN08667.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08667">
        <property type="protein sequence ID" value="PJN08667"/>
        <property type="gene ID" value="CG723_26580"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13302">
        <property type="entry name" value="Acetyltransf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="12"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN08667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="191" mass="20766" checksum="A58563E489CA7502" modified="2018-04-25" version="1">MIETPEIRGHGLLLRAWRAGDEGDAAAVLRGLGDPEFRRWNTPLTPVDDLAGAHEYLRSRQEALASGESVACCVTDESTGEVLGHVGLNAIMPVFRSAHVGYWVLPEARGRRVATRALNLASRLAFGELGLHRLELGHALGHEASCRVADRGGYRYEGTLRGAMFEAGRQDAFRDVHLHARLASDPEPPVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JPF3</accession>
    <name>A0A2M9JPF3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Aminoacyl-tRNA deacylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_27165</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000012">
        <property type="protein sequence ID" value="PJN08763.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08763">
        <property type="protein sequence ID" value="PJN08763"/>
        <property type="gene ID" value="CG723_27165"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002161">
        <property type="term" value="F:aminoacyl-tRNA editing activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.960.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036754">
        <property type="entry name" value="YbaK/aa-tRNA-synt-asso_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007214">
        <property type="entry name" value="YbaK/aa-tRNA-synth-assoc-dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04073">
        <property type="entry name" value="tRNA_edit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55826">
        <property type="entry name" value="SSF55826"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="tRNA_edit" evidence="1">
        <location>
            <begin position="36"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN08763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="168" mass="17752" checksum="787A26A0DD3BCA6E" modified="2018-04-25" version="1">MSTPEPAASAAHPRFAEALAELGLADVLPLVRRFPEATRTAQEAAAAIDCELSQICKSLIFAADGVPVLVLMDGASRVDVELVRRELGAEKVTRAKADVVRATTGYAIGGIPPFGHLTRTRVLADRSLLDHDTVWAAAGTPYAVFPMDPKSLIAHAGANLVDVRESAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JPN9</accession>
    <name>A0A2M9JPN9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">MerR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_25320</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000011">
        <property type="protein sequence ID" value="PJN08826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08826">
        <property type="protein sequence ID" value="PJN08826"/>
        <property type="gene ID" value="CG723_25320"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000551">
        <property type="entry name" value="MerR-type_HTH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13411">
        <property type="entry name" value="MerR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00040">
        <property type="entry name" value="HTHMERR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00422">
        <property type="entry name" value="HTH_MERR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="SSF46955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50937">
        <property type="entry name" value="HTH_MERR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH merR-type" evidence="2">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="97"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN08826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="134" mass="14903" checksum="3187C72425774BAA" modified="2018-04-25" version="1">MRIGELAERAGTTTRTLRYYESRGLLPARRGGNGYRTYDETDLRALRQIRTLQDFGFELEETRPFVECLRAGHPEGDSCPASLAVYRRKLGELDALIGELTAVREKVGAQLERAEEAMDALAGEDPSPRCELGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-09-29" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JPW4</accession>
    <name>A0A2M9JPW4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CG723_25325</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CB01635</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000011">
        <property type="protein sequence ID" value="PJN08827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08827">
        <property type="protein sequence ID" value="PJN08827"/>
        <property type="gene ID" value="CG723_25325"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004638">
        <property type="entry name" value="EmrB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00711">
        <property type="entry name" value="efflux_EmrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="60"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="87"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="112"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="147"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="174"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="207"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="233"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="276"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="315"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="364"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="7">
        <location>
            <begin position="22"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="552"/>
            <end position="590"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PJN08827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="590" mass="59898" checksum="B1BA30066CDA730B" modified="2018-04-25" version="1">MRLVMKEPVEGMDRPYARRWWALLVLCLSLLIIVMANTALTVAAPDMTKDLGLTSADLQWVIDGYTVPYAALMLLLGAIGDKYSRRGALILGLVVFGGGAVAGSLVDSSTGVIAARAVMGVGAAMIMPATLSLLAATFPRAERAKAIVLWTATAGLAIAAGPLVAGALLRNHGWSSTFLINVPVAAVALVGALVLVPPSKAAHRHRIDYVGGLLSVVWVGALVYMIIEGPHFGWGAKAIGAAVVAGLALVAFVLWELRHPRPVLDVRRFTDRRFSGSNLAVALFFLAVFGAFYYLTQHLQFVLGYDALATGVRMLPLAGAVFVGSALTGYLTPRIGMKITVTAGMVGGTAALALLTRIDASSAYGDFVLPLVILGLAIGLALSPCTDAIMGSFPESELGVGGAVNDTSLELGGSLGIAILGSVLAGSYSSQLADNTAGSKLPADALGTAQDSVGAGYAVAQGIGDQAHKVAEKAAGATSPEQAAQLKAQAEQLAGGARQMADAVGSAFSDAVAHTSVVGAVILGVGTVLVAVLLPRHGERTAGADAAADVVGEPDIAGEPGVAAETDAAAETSAVEPDAAEREPAAQGNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JQ33</accession>
    <name>A0A2M9JQ33_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Anti-sigma regulatory factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CG723_26145</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000011">
        <property type="protein sequence ID" value="PJN08966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08966">
        <property type="protein sequence ID" value="PJN08966"/>
        <property type="gene ID" value="CG723_26145"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PJN08966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="137" mass="14321" checksum="4FB2F03FDAC49360" modified="2018-04-25" version="1">MSQIAGEPGNQDFVEVRLPAAGAYLSVLRTATAGLAARLDFTLDEIEDLRIAVDEACAILLQQAVPGSVLSCVFRLVDDSLEVTVSAPTTDGRAPERDTFAWTVLSALAGKVDSTVADDNTVSISLYKQRGAGPGPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JQ96</accession>
    <name>A0A2M9JQ96_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Phosphate-binding protein PstS</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">pstS</name>
        <name evidence="7" type="ORF">CG723_24285</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CB01635</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Part of the ABC transporter complex PstSACB involved in phosphate import.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">The complex is composed of two ATP-binding proteins (PstB), two transmembrane proteins (PstC and PstA) and a solute-binding protein (PstS).</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the PstS family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000010">
        <property type="protein sequence ID" value="PJN09053.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN09053">
        <property type="protein sequence ID" value="PJN09053"/>
        <property type="gene ID" value="CG723_24285"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042301">
        <property type="term" value="F:phosphate ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035435">
        <property type="term" value="P:phosphate ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005673">
        <property type="entry name" value="ABC_phos-bd_PstS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024370">
        <property type="entry name" value="PBP_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12849">
        <property type="entry name" value="PBP_like_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002756">
        <property type="entry name" value="PstS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00975">
        <property type="entry name" value="3a0107s03"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0592">Phosphate transport</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014663954" description="Phosphate-binding protein PstS" evidence="5">
        <location>
            <begin position="30"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="domain" description="PBP_domain" evidence="6">
        <location>
            <begin position="56"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="region of interest" description="Phosphate binding" evidence="4">
        <location>
            <begin position="64"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Phosphate binding" evidence="4">
        <location>
            <begin position="200"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="94"/>
        </location>
        <ligand>
            <name>phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="112"/>
        </location>
        <ligand>
            <name>phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR002756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR002756-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF12849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PJN09053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="376" mass="38696" checksum="B6DA5D1DDE264DB9" modified="2018-04-25" version="1">MKLQRKNRLRALSLGAIAVSGALALTACGSDDTSANGGSSSGPTAKAGSIKCDDAKGQLLANGSSAQANAIQAWVKAYTAECKDVQINYKPEGSGAGVTAFTQGQVAFAGSDSALKPEEVTASKKVCSGGQGIDLPMVGGPIAVGYNVPGVDNLVLDAKTLAQIFDGKISTWDDAAIAKLNPKAKLPKTKIQAFHRSDESGTTDNFTKYLKAASPADWKYSGGKAWQAKGGQSAQGSSGLAQQVKQTAGAISYFELSYAKDGIKTVDLDTGASAPVKATVENATKAISEAKTVGTGKDLALELNYATKADGAYPITLVTYEIVCDKGNKADTFKATKSFLTYIASQDGQDSLAALGYAPIPAEINAKVRETVASLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JQP5</accession>
    <name>A0A2M9JQP5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Cobalamin/Fe(3+)-siderophore ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CG723_25120</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000010">
        <property type="protein sequence ID" value="PJN09193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN09193">
        <property type="protein sequence ID" value="PJN09193"/>
        <property type="gene ID" value="CG723_25120"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="4"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="255"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="36"/>
            <end position="43"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PJN09193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="287" mass="31026" checksum="E264DB831CB3E3C0" modified="2018-04-25" version="1">MTRLSTSALTLAYEDRTVVHDLDLAVPDGRVTVIVGPNACGKSTTLRALGRLLKPKSGSVLLDGEALTKLPTKKIAQQIGLLPQTPVAPEAITVADLVARGRQPHQHWWQQWSDADERAVTEAMERTDVAALADRSVDELSGGQRQRVWIAMALAQETELLLLDEPTTYLDIAHQVEVLDLLRQLNHDKDRTVVLVLHDLNQAARYADHLVAMKSGRIVAEGPPAEVVTADLVREVFGLDCVVVPDPVTGSPLIVPGAPWQADARPGERSVARPAAPSDSLSRKAAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JRC5</accession>
    <name>A0A2M9JRC5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GntR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_21920</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000008">
        <property type="protein sequence ID" value="PJN09440.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN09440">
        <property type="protein sequence ID" value="PJN09440"/>
        <property type="gene ID" value="CG723_21920"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07377">
        <property type="entry name" value="WHTH_GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1410.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028978">
        <property type="entry name" value="Chorismate_lyase_/UTRA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011663">
        <property type="entry name" value="UTRA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
        <property type="entry name" value="GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07702">
        <property type="entry name" value="UTRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00345">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00866">
        <property type="entry name" value="UTRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64288">
        <property type="entry name" value="SSF64288"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50949">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH gntR-type" evidence="1">
        <location>
            <begin position="2"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN09440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="264" mass="28952" checksum="FBE10D31E82D8E4A" modified="2018-04-25" version="1">MTPKWRELADKLADEIRRGEYAPGQQLPQIREQVAEGNGSKSTVHQAYKALEAEGLVTSSRGHGTVVRRQVPLKRLGIARYDKAKWRDGDEVAFIADRVASGRSYQRNEQTQTVSLVEAPPAVADAHGLPEGAQVYARARLVKEGDQPTHTLTSYYRPEHVEGTRIVDPTPGPAGRGGGFRVLYDAGYEIDHMKESIFARAATADEAKLLQLPAGEPVVELHRTTYTASGTVVEFAIGVHAASRFAWEYDFTVPDSAKGEKGQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JRK8</accession>
    <name>A0A2M9JRK8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NADPH:quinone reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_22345</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000008">
        <property type="protein sequence ID" value="PJN09503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN09503">
        <property type="protein sequence ID" value="PJN09503"/>
        <property type="gene ID" value="CG723_22345"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="PKS_ER"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PKS_ER" evidence="1">
        <location>
            <begin position="10"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN09503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="305" mass="32108" checksum="D2AE0C836644DDAF" modified="2018-04-25" version="1">MKAVRFHEYGGIDVLRVEEVERPVPGPAQVLVEVRAAGIQPGEAHIRTGALHERWPAAFPSGQGSDLAGVVVEVGPHVRGFSVGDEVLGFTHRRASHAEFVVVDDVNVVSRPKGLSWDVAGSLYVAGTTAYATVFAVDPGPADTVVVSGAAGGVGSLAVQLARRSGATVIGLASERNHAWLRDRGVVPVAYGEGVADRIRQASGGNVDAFIDTFGDGYVELAVELGVRPERINTISNWQAAAKVGAGTYGEGAAACAVVLGELARLAARGELKVPIAHAYPLERVRDAFRELERQHTHGKIVLRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JRL1</accession>
    <name>A0A2M9JRL1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GlcNAc-PI de-N-acetylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_22525</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000008">
        <property type="protein sequence ID" value="PJN09525.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN09525">
        <property type="protein sequence ID" value="PJN09525"/>
        <property type="gene ID" value="CG723_22525"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016137">
        <property type="term" value="P:glycoside metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10320">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003737">
        <property type="entry name" value="GlcNAc_PI_deacetylase-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024078">
        <property type="entry name" value="LmbE-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12993">
        <property type="entry name" value="PTHR12993"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02585">
        <property type="entry name" value="PIG-L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102588">
        <property type="entry name" value="SSF102588"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN09525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="277" mass="30105" checksum="348CF6A437AA6EA7" modified="2018-04-25" version="1">MTDRPLTLMAVHAHPDDEATGTGGVLARYAAEGIRTVLVTCTDGGCGDGPGGVKPGDPGHDPAAVALMRRQELEASCDVLKVSDLEMLDFADSGMMGWPSNDAPGSFWQTPVEEGAARLAELMRHYRPDVVVTYDENGFYGHPDHIQAHRITMAALEMTALTPKVYWTTMPRSMMQRFGETVRELHEDMPEPDPAEAAAMAEIGLPDDEITTWVDTTAFSGQKFDALAAHASQGENIFFLKMGKERFGELMGMETFVRVQDATGAAVPENDLFAGLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JRP7</accession>
    <name>A0A2M9JRP7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_22690</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000008">
        <property type="protein sequence ID" value="PJN09551.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN09551">
        <property type="protein sequence ID" value="PJN09551"/>
        <property type="gene ID" value="CG723_22690"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042925">
        <property type="term" value="F:benzoate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004711">
        <property type="entry name" value="Benzoate_Transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30199">
        <property type="entry name" value="PTHR30199"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03594">
        <property type="entry name" value="BenE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00843">
        <property type="entry name" value="benE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="15"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="50"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="98"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="149"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="173"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="257"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="293"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="323"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="353"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="397"/>
            <end position="417"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN09551.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="417" mass="42222" checksum="145738267F6269E0" modified="2018-04-25" version="1">MSPLARIRATAPPSAVAAGLIAVTVGVTSAAAIVFTAARAAGADAREVSSWMLALGVGIAVTCVGLSLRHKVPIVTSWSTPGAALLATSLSGVSMEKAVGAFVFSAVLIMVSGLTGWFARIMDRIPVPLASALLGGVLLEFGTGLFSQMGGSFAIAFPVFVLYLLGRRLLPRYAVLIALGGGVVASVLTGGWHLERVRLSLAQPVFTAPEFDWKVLISVGVPLFVVTMASQNLPGVAVLRGSGYEVPVSPVLTWTGAVQAVLAPFGAFGINLAAMTAAICAGDGAHPDRQRRYLAAVWAGVFYLCVGLLGATVASLLTAMPHALVLAVAGVGMLATIEASLASALSDPGSREAAVVTFLATASGVTLLGIGSAFWGLLAGVLTSVIVSVGRRRGAAASAPAPKPVTAASRTPERTSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JSF0</accession>
    <name>A0A2M9JSF0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">LLM class flavin-dependent oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_21175</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000007">
        <property type="protein sequence ID" value="PJN09717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN09717">
        <property type="protein sequence ID" value="PJN09717"/>
        <property type="gene ID" value="CG723_21175"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011251">
        <property type="entry name" value="Luciferase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036661">
        <property type="entry name" value="Luciferase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00296">
        <property type="entry name" value="Bac_luciferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51679">
        <property type="entry name" value="SSF51679"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bac_luciferase" evidence="1">
        <location>
            <begin position="18"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN09717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="326" mass="36111" checksum="426A67AF4472BCFB" modified="2018-04-25" version="1">MPVTVVRFNLVDPAATPESLSARYRAAVEMAAYADDRGISTVQTEEHHGVANNWLPSPFTFAGAVFGATRRIAVTVSAIIGPLHDPLRLAEDIAVLDLLSGGRLVTVAGIGYRPEEYGQFDVEWKRRGKLQDELLDTLLKAWTGEEFDFRGRTVRVTPRPFTQPHPLLLVGGSSRAAARRAARLGLPFFPSAHLPELEAYYKEQLVEHGTEGWTMMPAAVTPLLHVAEDPDRVWVEHGEHFLHEARTYASWQSGDIKSAVKSGATTVDELRAEGVYRILTPDECVEQALDSYVLHPLSGGMPVDEGWRSLHLFCENVLPRLEDRAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JT20</accession>
    <name>A0A2M9JT20_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CG723_20080</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000006">
        <property type="protein sequence ID" value="PJN10020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN10020">
        <property type="protein sequence ID" value="PJN10020"/>
        <property type="gene ID" value="CG723_20080"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PJN10020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="85" mass="9773" checksum="B26AC9BFF608B9E6" modified="2018-04-25" version="1">MTVALMWEARAAEGRGEELLAWARGQVLAAEPLRREFFRAPQDRVLVITWWDAAYEAELPELPDPEGELVTRTVHRWRFEAVAPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-06-02" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JT87</accession>
    <name>A0A2M9JT87_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5">50S ribosomal protein L36</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">rpmJ</name>
        <name evidence="6" type="ORF">CG723_20205</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CB01635</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4 5">Belongs to the bacterial ribosomal protein bL36 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000006">
        <property type="protein sequence ID" value="PJN10042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003974245.1">
        <property type="nucleotide sequence ID" value="NZ_NNBL01000006.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A2M9JT87"/>
    <dbReference type="EnsemblBacteria" id="PJN10042">
        <property type="protein sequence ID" value="PJN10042"/>
        <property type="gene ID" value="CG723_20205"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00251">
        <property type="entry name" value="Ribosomal_L36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000473">
        <property type="entry name" value="Ribosomal_L36"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035977">
        <property type="entry name" value="Ribosomal_L36_sp"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42888">
        <property type="entry name" value="PTHR42888"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00444">
        <property type="entry name" value="Ribosomal_L36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57840">
        <property type="entry name" value="SSF57840"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01022">
        <property type="entry name" value="rpmJ_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00828">
        <property type="entry name" value="RIBOSOMAL_L36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PJN10042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="37" mass="4401" checksum="C19DC4355BFEE26F" modified="2018-04-25" version="1">MKVKPSVKKICDKCRVIRRHGRVMVICDNPRHKQRQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JTA9</accession>
    <name>A0A2M9JTA9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_20065</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the YciI family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000006">
        <property type="protein sequence ID" value="PJN10017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN10017">
        <property type="protein sequence ID" value="PJN10017"/>
        <property type="gene ID" value="CG723_20065"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005545">
        <property type="entry name" value="YCII"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03795">
        <property type="entry name" value="YCII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YCII" evidence="2">
        <location>
            <begin position="3"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007689"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN10017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="118" mass="13229" checksum="03BCE4299A93ED66" modified="2018-04-25" version="1">MPRYMTLVRIDESKAPAEGPSEALMQRMGELIEEMTKAGVLLDTGGLHPSSEGTRVHYENGEITVTDGPFTESKEVIGGYAIIQAKDRAEILEWTKRFLKVHEEHWTVTSEIREIAEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JTG6</accession>
    <name>A0A2M9JTG6_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">UDP-N-acetylenolpyruvoylglucosamine reductase</fullName>
            <ecNumber evidence="17">1.3.1.98</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17">UDP-N-acetylmuramate dehydrogenase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="primary">murB</name>
        <name evidence="19" type="ORF">CG723_20510</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">CB01635</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3 17">Cell wall formation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 17">
            <text>NADP(+) + UDP-N-acetyl-alpha-D-muramate = H(+) + NADPH + UDP-N-acetyl-3-O-(1-carboxyvinyl)-alpha-D-glucosamine</text>
            <dbReference type="Rhea" id="RHEA:12248"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:68483"/>
            <dbReference type="ChEBI" id="CHEBI:70757"/>
            <dbReference type="EC" id="1.3.1.98"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 17">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="5 17">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4 17">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6 17">Belongs to the MurB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.98" evidence="17"/>
    <dbReference type="EMBL" id="NNBL01000006">
        <property type="protein sequence ID" value="PJN10159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN10159">
        <property type="protein sequence ID" value="PJN10159"/>
        <property type="gene ID" value="CG723_20510"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008762">
        <property type="term" value="F:UDP-N-acetylmuramate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007049">
        <property type="term" value="P:cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.43.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.78.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00037">
        <property type="entry name" value="MurB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016167">
        <property type="entry name" value="FAD-bd_PCMH_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003170">
        <property type="entry name" value="MurB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011601">
        <property type="entry name" value="MurB_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036635">
        <property type="entry name" value="MurB_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21071">
        <property type="entry name" value="PTHR21071"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02873">
        <property type="entry name" value="MurB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="SSF56176"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56194">
        <property type="entry name" value="SSF56194"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00179">
        <property type="entry name" value="murB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="15 17" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="8 17" id="KW-0132">Cell division</keyword>
    <keyword evidence="12 17" id="KW-0133">Cell shape</keyword>
    <keyword evidence="16 17" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="7 17" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10 17" id="KW-0274">FAD</keyword>
    <keyword evidence="9 17" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="11 17" id="KW-0521">NADP</keyword>
    <keyword evidence="14 17" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13 17" id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="18">
        <location>
            <begin position="37"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="active site" evidence="17">
        <location>
            <position position="180"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="17">
        <location>
            <position position="259"/>
        </location>
    </feature>
    <feature type="active site" evidence="17">
        <location>
            <position position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00003921"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00010485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="PJN10159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="371" mass="39186" checksum="64D8D2F4A05C6944" modified="2018-04-25" version="1">MEGDERPRHDRRGRSRTLERVQELHDAPLAPLTTFRLGGPAARLLTATTDDEVIAAVREADAAGTPLLIVGGGSNLVIGDKGFAGTALRIATKGFSLDGTNLELAAGEVWTDAVARTVEAGLAGIECLAGIPGSAGATPIQNVGAYGQEVSSTITEVIAYDRKTDETVTIRNEECAFSYRHSRFKADPERFVVLRVRFGLEDAGGMSAPIKYPETARTLGVEAGDRVPAALARETVLKLRAGKGMVLDPEDHDTWSAGSFFTNPILTEEEFAAFHARVADRLGPDTAPPAFPAGEARVKTSAAWLIDKAGFTKGYGSGPARISTKHTLALTNRGEATTDDLLALAREVVAGVHDAFGVTLVNEPVTVGVTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JTN3</accession>
    <name>A0A2M9JTN3_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">SSD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CG723_17795</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CB01635</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000005">
        <property type="protein sequence ID" value="PJN10245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN10245">
        <property type="protein sequence ID" value="PJN10245"/>
        <property type="gene ID" value="CG723_17795"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004869">
        <property type="entry name" value="MMPL_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000731">
        <property type="entry name" value="SSD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03176">
        <property type="entry name" value="MMPL"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50156">
        <property type="entry name" value="SSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014644130" description="SSD domain-containing protein" evidence="8">
        <location>
            <begin position="37"/>
            <end position="747"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="180"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="207"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="234"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="275"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="304"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="375"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="531"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="562"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="595"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="646"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="675"/>
            <end position="699"/>
        </location>
    </feature>
    <feature type="domain" description="SSD" evidence="9">
        <location>
            <begin position="204"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="727"/>
            <end position="747"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PJN10245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="747" mass="77464" checksum="0063CC9C29511AA7" modified="2018-04-25" version="1">MATFLYKLGRLSFRRRRYVALLWVLLLGGIGYASSAAPAPPADSFSMPGTDSQKAFDLLDERFPAASAEGATARVVIRAPEGEKITDPAAKAEVRRLVTALGKGPQVAGVADPYKANAVSKDGTTAYASVTYKVISTELTDKTHDALTDATDKTRAEGFAVETGGDAVQAEQEMGGSAELIGIAVSAVVLVITFGSLIAAGLPLLTAIIGVGIGVSGIAALGSVLNLSGTTSTLAMMIGLAVGIDYALFIVSRYRAEIAEGREPEEAAGRATGTAGSAVVFAGLTVIVALAGLSVVNIPMLTKMGLAAAATVAIAVLIALTMIPALLGFAGKRALRRRDRKNLAKPVAAHSARDAKDAKPNLGTRWARLVLRRPVTVLLIGVLGLGAVAVPATSLELGLPDEGTSAPDTTQRKAYDMLSESFGAGFNGPLMVTVDTGGAKDAAAAAKTVGTSLAKVDGVAAVTPASVNPAGDTAIITVVPTTGPSDHKTEELVKTIRSTASGLEADTNSDVLVSGQTAMTIDFSQTLNDALLPYLGLVVGLAFLLLMLVFRSVLVPLKAALGFLLSVAAALGAVVAVFQWGWLADIVGVDQPGPIMSMMPIFMIGVVFGLAMDYEVFLVTRMREAYVHGARPGEAVVTGFKHGGRVVGAAAIIMISVFSGFIMENNDMIKMMGFGLAIAVFFDAFVVRMAIVPAVLALLGKSAWWLPRWLDKILPNVDVEGEKLHKTLAPSSSPAAEEERELEPVRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JU07</accession>
    <name>A0A2M9JU07_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">PucR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CG723_18185</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CB01635</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CdaR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000005">
        <property type="protein sequence ID" value="PJN10312.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN10312">
        <property type="protein sequence ID" value="PJN10312"/>
        <property type="gene ID" value="CG723_18185"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2840">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041522">
        <property type="entry name" value="CdaR_GGDEF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025736">
        <property type="entry name" value="PucR_C-HTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042070">
        <property type="entry name" value="PucR_C-HTH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012914">
        <property type="entry name" value="PucR_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17853">
        <property type="entry name" value="GGDEF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13556">
        <property type="entry name" value="HTH_30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07905">
        <property type="entry name" value="PucR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PucR" evidence="2">
        <location>
            <begin position="6"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="domain" description="GGDEF_2" evidence="4">
        <location>
            <begin position="295"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="domain" description="HTH_30" evidence="3">
        <location>
            <begin position="466"/>
            <end position="523"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF17853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PJN10312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="543" mass="57890" checksum="797FE97C886B9B8E" modified="2018-04-25" version="1">MHIEHLLRDESLGLRLLWADEPQLRQEISGVTVTDLEDPARFVRPAEVVLSGLVWWTQRSGRAKADRFVSALRTAGAAVLLAGEETHGAVPDDLVEACRRHGLPVAAVPAHIMFRAITDTVYLQQWGELSRHHALPENVRATLSRLLAQEADPAALVDAAFAHLDRPVAYVLTPTGRTVAATTASADLATRDAAALIATGTFPAQRSGHNSSGTGARPPFGRASVTLPVQADTDAVSPYERWHLHVPDPDDAPPRMLHEIVEILGRCQEIRARRRADEDRAVRELGTLLTAPDTDKAVLEAALRGCGLPDEGPYHVVVAEAGSGREDSAQGALTEAAAHVPHTGTAAGQLPDGTAFAVIAGADAVSEALADVWPLLATCEPSDPLHAGIASPAAAPRNLNGALSEARYALTSARTTAPAASRLTDAASLTGLETLLTGVPAEVRAAFSRTVLGPLLDETNASATALLQTLETFLACDGSWARTAEALHLHVNTVHYRIQRIEHFTGRDLSRLYDRADLWAALLSREEPATNGRRARSSTSRAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JU12</accession>
    <name>A0A2M9JU12_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Daunorubicin resistance protein DrrC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_18430</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000005">
        <property type="protein sequence ID" value="PJN10353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN10353">
        <property type="protein sequence ID" value="PJN10353"/>
        <property type="gene ID" value="CG723_18430"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="2">
        <location>
            <begin position="17"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="2">
        <location>
            <begin position="490"/>
            <end position="785"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="50"/>
            <end position="57"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="524"/>
            <end position="531"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN10353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="796" mass="84454" checksum="94CF9C3A2F79440D" modified="2018-04-25" version="1">MSMAKGTQAQSAALHAADSHDLIRVHGARVNNLKDVSVELPKRRLTVFTGVSGSGKSSLVFGTIAAESQRMINETYSTFVQGFMPTLARPEVDVLDGLTTAIIVGQERMGGDARSTVGTATDANAMLRILFSRLGKPHIGSAKAFSFNVASISGAGAVAIERGGETVKERRSFSIVGGMCPRCEGRGSVTDFDLTALFDDSKSLNEGALTVPGYSVEGWYGRIYRGCGFFDPDKPIRKFTKKELHDLLHREPTKIKVDGINLTYEGLIPKIQKSMLSKDIDSLQPHIRAFVERAMTFTSCPDCGGTRLSEAARSSKIKKISIADACSMQISDLAEWVRALKEPSVAPLLKALGDTLDSFVEIGLGYLGLDRPAGTLSGGEAQRVKMIRHLGSSLTDVTYVFDEPTIGLHPHDIQRMNDLLLRLRDKGNTVLVVEHKPEAIAIADHVVDLGPRAGTEGGEVVFEGTVEGLRASDTLTGQHLDDRASLKPTVRTPTGKLGVRGAGTNNLQDVDVDIPLGVLTVVTGVAGSGKSSLIHGSVAGQDGVVTVDQAAIRGSRRSNPATYTGLLDPIRKAFAKANGVKPALFSANSEGACPTCNGAGVIYTDLAMMAGVASTCDDCEGKRFQASVLDYHFGGRDISEVLAMPVAEAEQFFGAGEARTPAAQKILQRMADVGLGYLTLGQPLTTLSGGERQRLKLATHMAEKGGVYVLDEPTTGLHLADVEQLLGLLDRLVDSGKSVIVIEHHQAVMAHADWIIDLGPGAGHDGGRIVFEGTPAELVADRSTLTGEHLAAYVGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JUF2</accession>
    <name>A0A2M9JUF2_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Peptide chain release factor 2</fullName>
            <shortName evidence="4">RF-2</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">prfB</name>
        <name evidence="7" type="ORF">CG723_14945</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CB01635</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="4">Methylated by PrmC. Methylation increases the termination efficiency of RF2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the prokaryotic/mitochondrial release factor family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000004">
        <property type="protein sequence ID" value="PJN10521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN10521">
        <property type="protein sequence ID" value="PJN10521"/>
        <property type="gene ID" value="CG723_14945"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016149">
        <property type="term" value="F:translation release factor activity, codon specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00094">
        <property type="entry name" value="Rel_fac_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005139">
        <property type="entry name" value="PCRF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000352">
        <property type="entry name" value="Pep_chain_release_fac_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045853">
        <property type="entry name" value="Pep_chain_release_fac_I_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004374">
        <property type="entry name" value="PrfB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03462">
        <property type="entry name" value="PCRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00472">
        <property type="entry name" value="RF-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00937">
        <property type="entry name" value="PCRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75620">
        <property type="entry name" value="SSF75620"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00020">
        <property type="entry name" value="prfB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00745">
        <property type="entry name" value="RF_PROK_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 4" id="KW-0488">Methylation</keyword>
    <keyword evidence="3 4" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RF_PROK_I" evidence="6">
        <location>
            <begin position="244"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="52"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="modified residue" description="N5-methylglutamine" evidence="4">
        <location>
            <position position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS00745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PJN10521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="368" mass="41090" checksum="998DACC4E3023E03" modified="2018-04-25" version="1">MAVVDVSEELKSLSSTMESIEAVLDLDKLRADIAVLEEQAAAPSLWDDPDAAQKITSKLSHLQAEVRKAETLRGRIDDLSVLFEMAEEENDPDTRAEAESEMTSVKKALDEMEVRTLLSGEYDSREALVNIRAEAGGVDAADFAEQLQRMYLRWAERHGYKTEVYETSYAEEAGIKSTTFAVQIPYAYGTLSVEQGTHRLVRISPFDNQGRRQTSFAGVEVLPVVETTDHVEIDESELRVDVYRSSGPGGQGVNTTDSAVRLTHLPTGIVVSCQNERSQIQNKATAMNVLQAKLLERQRQEERAKMDALKGDGGSSWGNQMRSYVLHPYQMVKDLRTEFEVGNPQSVLDGEIDGFLEAGIRWRKQQEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JUW3</accession>
    <name>A0A2M9JUW3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF397 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_15555</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000004">
        <property type="protein sequence ID" value="PJN10628.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN10628">
        <property type="protein sequence ID" value="PJN10628"/>
        <property type="gene ID" value="CG723_15555"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007278">
        <property type="entry name" value="DUF397"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04149">
        <property type="entry name" value="DUF397"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF397" evidence="1">
        <location>
            <begin position="14"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN10628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="73" mass="7738" checksum="2C0106FFFB64D0E3" modified="2018-04-25" version="1">MTEPIIWNAAGLNGWRKSSYSGSEGGSCLEVLDNHPTGIPVRDSKTPNGPALVFPSTGWSSFITAVKAGSFHF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JUY6</accession>
    <name>A0A2M9JUY6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Amidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_15830</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000004">
        <property type="protein sequence ID" value="PJN10674.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN10674">
        <property type="protein sequence ID" value="PJN10674"/>
        <property type="gene ID" value="CG723_15830"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1300.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000120">
        <property type="entry name" value="Amidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020556">
        <property type="entry name" value="Amidase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023631">
        <property type="entry name" value="Amidase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036928">
        <property type="entry name" value="AS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11895">
        <property type="entry name" value="PTHR11895"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01425">
        <property type="entry name" value="Amidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75304">
        <property type="entry name" value="SSF75304"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00571">
        <property type="entry name" value="AMIDASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidase" evidence="1">
        <location>
            <begin position="26"/>
            <end position="447"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN10674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="467" mass="48698" checksum="14ABAEBDD20FA35E" modified="2018-04-25" version="1">MTDLTELTAEALVDGYRKGGFSPVDATRAVLRRIEEVDPAVNAFVRLDTETALAQAKASAERWRRGEPQGLVDGVPVSVKDILLMRGGPTLRGSRTVRAEGAWDEDAPSVARLREHGAVFVGRTTTPEFGWKGVTDSPLSGATRNPYDLSRTSGGSSGGSAAAVALGAGPLSLGTDGGGSVRIPAAFCGIFGLKPTYGRVPLYPASAFGTLSHVGPMTRDVADAALMMDVITGADWRDWSQLGPVEGGFRDGLSGGVRGLRVAFSPSFGGQVAVRPAVAAAVRKAVEGLAGLGAYVEEADPDVTDPVEAFHTLWFSGAARVTQNLSPAQRALLDPGLREICAQGSGYSALAYLAAVDVRAELGRRMGRFHSTYDLLVTPTLPLTAFEAGTEVPKGSGLRRWTGWTPFTYPFNLTQQPAATVPVGVDADGLPVGLQIVGARHADALVLRAAHSLYEAGIAGIPAPTLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JV60</accession>
    <name>A0A2M9JV60_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Serine/threonine protein phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_16445</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000004">
        <property type="protein sequence ID" value="PJN10771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN10771">
        <property type="protein sequence ID" value="PJN10771"/>
        <property type="gene ID" value="CG723_16445"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00143">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase_dom"/>
    </dbReference>
    <dbReference type="SMART" id="SM00331">
        <property type="entry name" value="PP2C_SIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00332">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="SSF81606"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51746">
        <property type="entry name" value="PPM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPM-type phosphatase" evidence="2">
        <location>
            <begin position="176"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="33"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN10771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="442" mass="45688" checksum="D71E28504E93466C" modified="2018-04-25" version="1">MMSQMPRPTAMSTCPSCEEPLESGDRFCGACGYDLSAVPAPPDDLPAVTPAADGAVPAENPAVDWPSAPELDSSDTPAPVHLPTDLQGTDSGGSELPSAVRFDGVPEQAGESAAGDYTLPAPDPRTVPPESLATPPAGTKLCVACRAGQVDRDGYCENCGHAQPRERDHMEQELGAVAAVSDRGLRHHRNEDAFAIASAALPDGTPSVVSIVCDGVSSATRPDEASLAASRAASEALLESLPRGTHPQQAMHDAIVVAAEAVNTLAQEPGSAREHAPHQNAPACTLVGAIVAKDLLIVGWVGDSRAYWVPDDRTAPAARLTEDDSWAAQMVAAGLMNEAEAYADERAHAITGWLGADAYELEPHTASFKPDRPGVVVVCTDGLWNYAEAAEEMARVIPADAAHRPLHSAQVLVGHALDGGGHDNVTVAVLPFPVPPAGAGSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JVA3</accession>
    <name>A0A2M9JVA3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">EamA family transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CG723_16585</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000004">
        <property type="protein sequence ID" value="PJN10794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN10794">
        <property type="protein sequence ID" value="PJN10794"/>
        <property type="gene ID" value="CG723_16585"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000620">
        <property type="entry name" value="EamA_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00892">
        <property type="entry name" value="EamA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="34"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="65"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="96"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="176"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="206"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="240"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="270"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="295"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="3">
        <location>
            <begin position="32"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="3">
        <location>
            <begin position="176"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PJN10794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="321" mass="32988" checksum="F5ABAED714060F48" modified="2018-04-25" version="1">MAVLDRTTTSAEKAASGGGGAGGRRAGNGLGTGLALALLATVVWSGSFVTSRALHDSVPPIQHAFWRWIIAIAAVAPFAARSAWRQRALLRAHLRFLLLAAMLGVTVYNTLVNQAAMTTSAGNMGMIMAASPVLMAAYERLGGVRLGARRVTGTVIACAGVLLLVSKGSLAPDFTAGDLWVVAAAVCFGSYSALLRRRPAEIGGPAFLFATFVLGALMLLPVFLVSLAVQGGFEPTAATVSPLLYVGVVSSAVAFLAWNKAIAQIGAARAGVIYYLQPVCVALLSYAVLGEAMGGLQIACMALILAGVALGSATRGETRIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JVF2</accession>
    <name>A0A2M9JVF2_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">GTPase Obg</fullName>
            <ecNumber evidence="6">3.6.5.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">GTP-binding protein Obg</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">obgE</name>
        <name evidence="11" type="synonym">cgtA</name>
        <name evidence="6 11" type="synonym">obg</name>
        <name evidence="11" type="synonym">yhbZ</name>
        <name evidence="11" type="ORF">CG723_16880</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CB01635</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="6">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.5.-" evidence="6"/>
    <dbReference type="EMBL" id="NNBL01000004">
        <property type="protein sequence ID" value="PJN10844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN10844">
        <property type="protein sequence ID" value="PJN10844"/>
        <property type="gene ID" value="CG723_16880"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01898">
        <property type="entry name" value="Obg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.210.12">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.350">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01454">
        <property type="entry name" value="GTPase_Obg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031167">
        <property type="entry name" value="G_OBG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014100">
        <property type="entry name" value="GTP-bd_Obg/CgtA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036346">
        <property type="entry name" value="GTP-bd_prot_GTP1/OBG_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006074">
        <property type="entry name" value="GTP1-OBG_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006169">
        <property type="entry name" value="GTP1_OBG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036726">
        <property type="entry name" value="GTP1_OBG_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045086">
        <property type="entry name" value="OBG_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015349">
        <property type="entry name" value="OCT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11702">
        <property type="entry name" value="PTHR11702"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09269">
        <property type="entry name" value="DUF1967"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01018">
        <property type="entry name" value="GTP1_OBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00326">
        <property type="entry name" value="GTP1OBG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102741">
        <property type="entry name" value="SSF102741"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82051">
        <property type="entry name" value="SSF82051"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02729">
        <property type="entry name" value="Obg_CgtA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03595">
        <property type="entry name" value="Obg_CgtA_exten"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51710">
        <property type="entry name" value="G_OBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00905">
        <property type="entry name" value="GTP1_OBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51883">
        <property type="entry name" value="OBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51881">
        <property type="entry name" value="OCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Obg" evidence="10">
        <location>
            <begin position="2"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="domain" description="OBG-type G" evidence="8">
        <location>
            <begin position="160"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="domain" description="OCT" evidence="9">
        <location>
            <begin position="348"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="60"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="439"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="166"/>
            <end position="173"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="173"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="191"/>
            <end position="195"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="193"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="212"/>
            <end position="215"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="282"/>
            <end position="285"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="311"/>
            <end position="313"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PJN10844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="478" mass="50842" checksum="5C5C6D357F7429A1" modified="2018-04-25" version="1">MTTFVDRVELHVAAGSGGHGCASVHREKFKPLGGPDGGNGGRGGDVILVVDQSVTTLLDYHHSPHRKATNGKPGEGGNRSGKDGQDLVLPVPDGTVILDKAGNVLADLVGQGTTYVAAQGGRGGLGNAALASARRKAPGFALLGVAGDLQDIVLELKTVADIALVGYPSAGKSSLISVLSAAKPKIADYPFTTLVPNLGVVTAGSTVYTIADVPGLIPGASQGKGLGLEFLRHVERCSVLVHVLDTATLESDRDPVSDLDIIEAELKQYGGLDNRPRLVVLNKVDVPDGQDLADLVRPDLEARGYRVYEVSAVAHKGLKELSFALAEMVASARAAKPKEEATRIVIRPKAVDDSGFTVVQEEDGLFRVRGEKPERWVRQTDFNNDEAVGYLADRLNRLGVEDSLMKAGAVAGDGVAIGPEDNAVVFDWEPTVMAGAEMLGRRGEDHRMEEPRPAAQRRRDKQAERDDAEQEYDEFKPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JVJ7</accession>
    <name>A0A2M9JVJ7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Cytidine deaminase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CG723_17140</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000004">
        <property type="protein sequence ID" value="PJN10889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN10889">
        <property type="protein sequence ID" value="PJN10889"/>
        <property type="gene ID" value="CG723_17140"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016193">
        <property type="entry name" value="Cytidine_deaminase-like"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53927">
        <property type="entry name" value="SSF53927"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PJN10889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="117" mass="11544" checksum="49DF9395A6D1E1E9" modified="2018-04-25" version="1">MTESNDLTAEDRKIVTLARSARARNGVPEGAAVRDETGRTYVAGTVSLDSLKLSALRTAVAMAVASGAQSLEAAAVVSDGSEVGGEDLAAVRDLGGAGTPVFLAGTDGVVRGAVAAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JVK5</accession>
    <name>A0A2M9JVK5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_15760</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000004">
        <property type="protein sequence ID" value="PJN10925.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN10925">
        <property type="protein sequence ID" value="PJN10925"/>
        <property type="gene ID" value="CG723_15760"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021994">
        <property type="entry name" value="DUF3592"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12158">
        <property type="entry name" value="DUF3592"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="121"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN10925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="146" mass="16025" checksum="07A073770F22AD19" modified="2018-04-25" version="1">MQVLFLIVPVFIASVAIFMAVALTRRSMQMRRAWASGLTAEARCLRAFTSTRRDDDGFRSTTQHHVYEFTAGDGRPVRFEEANGPATTVQGDVVMVYYTADRPDRATAHAPAPVRAAAGMVFLLGFLGLVVAFCVFFVVVAAEMPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-09-29" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JVQ0</accession>
    <name>A0A2M9JVQ0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CG723_16470</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000004">
        <property type="protein sequence ID" value="PJN10950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN10950">
        <property type="protein sequence ID" value="PJN10950"/>
        <property type="gene ID" value="CG723_16470"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PJN10950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="161" mass="17734" checksum="C7A1BB2C79416199" modified="2018-04-25" version="1">MTQPPQPPQPPQRPQWPRADLDPVRRLHALASGISGAHVTEGRVDAPYARVWALLGDLEGEFGRITPDMRGLRVLRRDGERVEALAISKYGMRARLRGVHRPGWCWLQSRFLLLGVAAAPDGDGTRVAFTGGVRVPGRAALVPVGVRREGRRSLERLTALL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JVW4</accession>
    <name>A0A2M9JVW4_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Neutral metalloproteinase</fullName>
            <ecNumber evidence="7">3.4.24.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CG723_17185</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CB01635</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Extracellular zinc metalloprotease.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the peptidase M4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.-" evidence="7"/>
    <dbReference type="EMBL" id="NNBL01000004">
        <property type="protein sequence ID" value="PJN10897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN10897">
        <property type="protein sequence ID" value="PJN10897"/>
        <property type="gene ID" value="CG723_17185"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023612">
        <property type="entry name" value="Peptidase_M4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027268">
        <property type="entry name" value="Peptidase_M4/M1_CTD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001570">
        <property type="entry name" value="Peptidase_M4_C_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013856">
        <property type="entry name" value="Peptidase_M4_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01447">
        <property type="entry name" value="Peptidase_M4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02868">
        <property type="entry name" value="Peptidase_M4_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00730">
        <property type="entry name" value="THERMOLYSIN"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 7" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="2 7" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0964">Secreted</keyword>
    <keyword evidence="4 7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase_M4" evidence="8">
        <location>
            <begin position="77"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M4_C" evidence="9">
        <location>
            <begin position="186"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="176"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="6">
        <location>
            <position position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR623612-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU366073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PJN10897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="357" mass="38497" checksum="DE3EF405CEA00BBD" modified="2018-04-25" version="1">MTANRSGFEPVFCTIVPPHILDKAARSGDPALSALARRTLERDALERTRRRLTTVIGAPSVAAPMDAVEHKPHRTLYDAGHRTELPGTKVRGEGDEPGRDATVNRAYAGLGATFELYLEKYARDSIDGSGLPLKASVHFDNDYNNAFWNGEQMVFGDGDGEIFLDFTIPVDVIGHELTHGVTQYTANLTYFGQPGALNESVSDVFGSLIKQYSLGQGAADADWLIGAGLLAPRVTGKALRSMKAPGTAYDDDVLGKDPQPADMDHFVRTSSDNGGVHINSGIPNHAFYLLAVALGGNAWERAGQIWYDVLTGGELAQDASFADFAKLTAKAARTRYKDGEELESVQKAWSQVGVPTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JW15</accession>
    <name>A0A2M9JW15_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Protein phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_08875</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN11076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN11076">
        <property type="protein sequence ID" value="PJN11076"/>
        <property type="gene ID" value="CG723_08875"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013656">
        <property type="entry name" value="PAS_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01590">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13581">
        <property type="entry name" value="HATPase_c_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08448">
        <property type="entry name" value="PAS_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07228">
        <property type="entry name" value="SpoIIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00065">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00331">
        <property type="entry name" value="PP2C_SIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="SSF81606"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PAS" evidence="1">
        <location>
            <begin position="16"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN11076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="699" mass="76227" checksum="89AB4876D6541A9F" modified="2018-04-25" version="1">MNTSPDIPGGTSRDVDDATLRALFSESPIGLHILDTQLRLVRFNAAARYIRAFPVEDLLGRTVAEVLREYGKDQADEVEAMVREVLETGRPRRDVLLTLRSLQPPHAEVAVQASWFRLQDLEGCPLGVAAAILDVTDRNQAQARLALLDRVGSRIGTALDLFDTAQELAEGTVPDFADFTTVDLFDPVLRGEAPEPGPHLGTIPLRRAGWCSHGSPVTAGWPVAGEVSGFPSGTPYRESLTDLLPRLVARLVPDAEWLDRDPVRGRLLRRNLVHSMIVVPMCARGVVLGLACFYRGRRPDPYVDEDTALAAQLVARTALSLDNIRLYNRERSAARLLQLSLRPPEVPVHAAVETAHSYLPSGSGGDWFDVIPLSGARVALIAGDTEGQGLHAAAAMGELRAAIGALADLDVPPDELLERLHDLVTRLDDEVTSTPHDASRYRVVGTTCLYVVYDPVIRRCTMSSAGHPPPVIIRPDGTAELADVPQGPPLGQGVATHRITERELPEGSILLLCNTPLVQDRDPQQAVQQLDRIRAALAPESRCLQETCERVLRVLPADGHQHDPVLLMARTRAKGPDQVASWTLRGAPEAAAEARRLTADRLSAWGLEDLEDTTELVVSELVTNAVRYSEGPIGLRLIRDRTLICEVSDTSSTAPHLRHAEADEESGRGLFITAQLTQRWGTRPARRGKTIWAELSLSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JWA5</accession>
    <name>A0A2M9JWA5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_09270</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN11139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN11139">
        <property type="protein sequence ID" value="PJN11139"/>
        <property type="gene ID" value="CG723_09270"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="18"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN11139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="102" mass="10443" checksum="6C5298A6D47699A7" modified="2018-04-25" version="1">MTMVTYARRVGDASDLGLASGDAAGQRAQRGDRADDGVAVRAAERAGAGVGGPQLRPACGLLGREGAEQFGELEQACLGVRGECPGLGRVVVVETWADSSKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JX01</accession>
    <name>A0A2M9JX01_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Serine protease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CG723_10950</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CB01635</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN11425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN11425">
        <property type="protein sequence ID" value="PJN11425"/>
        <property type="gene ID" value="CG723_10950"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.50">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004236">
        <property type="entry name" value="Pept_S1_alpha_lytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001316">
        <property type="entry name" value="Pept_S1A_streptogrisin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035070">
        <property type="entry name" value="Streptogrisin_prodomain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02983">
        <property type="entry name" value="Pro_Al_protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001134">
        <property type="entry name" value="Streptogrisin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00861">
        <property type="entry name" value="ALYTICPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="SSF50494"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 10" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015006594" evidence="7">
        <location>
            <begin position="31"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="domain" description="Pro_Al_protease" evidence="9">
        <location>
            <begin position="121"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S1" evidence="8">
        <location>
            <begin position="220"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="225"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="253"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="335"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="210"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="293"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="329"/>
            <end position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR001134-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR001134-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PJN11425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="381" mass="39324" checksum="7A9D67BECCCFBA88" modified="2018-04-25" version="1">MRRTKSLRIALSALLVAGVSAGFIPASAGAATPADEKAPASGSVLAAMQRDFGLTKSQAEARLSAEKKATAVEEKARRAAGSSYGGAWFTPESGRLTVAVTDRSKAAAVRSTGAEAKLVKYSAKQLDAAKERIDALKAPKGVASWHVDPASNRIVIETLAGQQGDNDVKHFLAQAREAGPVTVEKTAHAPRTLAAGTVGGDPYYTGNVRCSIGFSVNGGFVTAGHCSGAGAAVNGWDGSYIGNFQGSSFPDNDYAWVNVGSGWWTVPVVLGWGTVPDQLVRGSAEAPIGASICRSGSTSHWHCGNVLAKNETVNYSQGAVHEMTKTNVCAEPGDSGGSFISGDQAQGVTSGGWGDCSGGGETWYQPINEILNRYGLTLTTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JXD6</accession>
    <name>A0A2M9JXD6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Molybdopterin biosynthesis protein MoeE</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CG723_10905</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN11417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN11417">
        <property type="protein sequence ID" value="PJN11417"/>
        <property type="gene ID" value="CG723_10905"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006777">
        <property type="term" value="P:Mo-molybdopterin cofactor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00756">
        <property type="entry name" value="MoaE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1170.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036563">
        <property type="entry name" value="MoaE_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003448">
        <property type="entry name" value="Mopterin_biosynth_MoaE"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02391">
        <property type="entry name" value="MoaE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54690">
        <property type="entry name" value="SSF54690"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PJN11417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="149" mass="15900" checksum="4107E07A1F5643CF" modified="2018-04-25" version="1">MPHIPDLSGHHPVQLLALRDTPLSLDEVYEAVGDAAAGGTAVFVGTVRNHDGGRSVDALEYSAHPAAESEMRRVAEKVAADFPVSALAAVHRTGRLEIGDVAVIAAVSCPHRAEAFAACARLVEDLKHEVPIWKHQFFSDGDEEWVGAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-09-29" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JXE2</accession>
    <name>A0A2M9JXE2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CG723_11700</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CB01635</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN11555.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN11555">
        <property type="protein sequence ID" value="PJN11555"/>
        <property type="gene ID" value="CG723_11700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000849">
        <property type="entry name" value="Sugar_P_transporter"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002808">
        <property type="entry name" value="Hexose_phosphate_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="34"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="72"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="99"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="125"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="167"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="192"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="261"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="301"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="332"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="357"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="387"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="414"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="7">
        <location>
            <begin position="36"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="222"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PJN11555.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="446" mass="46347" checksum="80C14F358FE74666" modified="2018-04-25" version="1">MPDGTRPGTALDPLRSPAAAPGSVRRSQRWRWQIFAVTWIAYAGFYFVRQAFPVAKLGILDDPAVNHTLTSHTLGVIDAVYLAAYAVGQFAWGSWADRFGPRVVVIGGMAGAVVASAVIGLSSSLVVFGVAMAVQGLAQSTGWAPLCKNVTSFVPVKDRGRILGLWCTNYAFGGLAAPPFLGWWAYSVFDSWHAAFLAGSATLAVVLVLFVVFQRNEPADVGLPRPDAPETTAGSGAVPEPAEAPPTSREIYREILRNRMVLTLSAAYFLLKPARYALLLWGPVIVSERLPEVGKLEATLIPVAFGVAGVLAPMTVGWISDRLFSSRRVPPCVLSLGLLTVMLAAFAPLTATGSTGTMVGVLAVIGFGLYAADALIAGVAAVDSGGLAGAGTATGFVNGCGSVGAILGGLLPGFLATTVLFYGFAAAAALAGVVMLPHWNRTAVTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JXG7</accession>
    <name>A0A2M9JXG7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CG723_11865</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN11579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN11579">
        <property type="protein sequence ID" value="PJN11579"/>
        <property type="gene ID" value="CG723_11865"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PJN11579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="340" mass="36645" checksum="09EE40A3618C464E" modified="2018-04-25" version="1">MRRWIKVAVAAAAAVGLGGYMAEPYAQDWWLVGRACDGALPRDSVAQLTPDDAQFTKEESRRVPELGFYGCSLAFDGDDTEGVTLVAMSAYTGRDDQDREFKRAFPEGGFTPNGVLSGGLPGTVDDAGVMRIVTQCPALGKDAEGRQRKMLVRVGTFGDVDRSALGAVYRTAVALANSASKNLSCGARPLKVPHRTTGFDTEERWRRAVSPAKAEGTGCDWVSRAGLAKDAGWRLVAETNDTAPMGTCDLRTDEGGDAYQAGMTFGAWYGDWSSRLTASDDNGERRPLTATARCDGEAANFALDATKDTPGVDKAERRRLLKAFAEDQVRRRGCSGLRFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JXH9</accession>
    <name>A0A2M9JXH9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CG723_11600</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CB01635</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN11538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN11538">
        <property type="protein sequence ID" value="PJN11538"/>
        <property type="gene ID" value="CG723_11600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="22"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="56"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="87"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="113"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="146"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="174"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="227"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="251"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="278"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="319"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="346"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="369"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="405"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="433"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="7">
        <location>
            <begin position="22"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="475"/>
            <end position="494"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PJN11538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="494" mass="52879" checksum="877B92A497B29070" modified="2018-04-25" version="1">MHTTAKPPLPWYREVSRPQWKAFFAAWIGYVLDGFDFVLITLVLTEISSEFGLSTVQAASLISGAFITRWLGGAVLGALGDRYGRKLSMVLSILLYSLGTFACGFAWDYTSLFVARLAIGMGMAGEYSASATYVMESWPTRVRNRASGFLISGFSMGSVLAAQVYNWVVPTLGWRWMFCVGLVPIVVALWMRRALPEAADWSESVGRQSEKERPNPFRPLFATPARATVNVVLAVAATVSLFAIFTPVGDGLVPALSVVAAVALIAFAVQLGGRKSWLLYVSMIVTIFFAFLYSWPIQALLPTYLKTELGYSPGQVTDALYFAGFGTMAGCWLAGFAGDWMGTKKAYALTLLASLVFVFPVFAVRDDLLLLGVLLFVLQATSFGISGLLPRYIGGHFPTENRAAALGFTYNVGALGGAVAPVLGAHLAAGMDLGRALAVLTFAGTVIVVLLVGFDIPGRLNRLTDPDGTVDHLAEAAPETATSPSDGQVPAASR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JXS8</accession>
    <name>A0A2M9JXS8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Alpha/beta hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CG723_12455</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN11674.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN11674">
        <property type="protein sequence ID" value="PJN11674"/>
        <property type="gene ID" value="CG723_12455"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PJN11674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="503" mass="53072" checksum="A75D9AF5610DA50A" modified="2018-04-25" version="1">MTAFILVAGTHTGGWVWREVAAGLRDAGARAYEVTLSGMDGGGGAAGPGVDLETHIEELVRLIDRVEGQDVVLVGHCYGIHPVRGAADRRSERISRIVNVDVGIPEDGDPALKLVPDQTDRERVLSLAREDSAGTLPAPTVEEWQRWGSVAGLPADALARLTEQAAPQPLPTLTQPLRLSGAVAELPTTGVLCTANGSSIAVVEAMVGLGDPAFQALADQGVTFFELGTGHWPMLSAPRELVDVLLRAAAGKGHRVAAVREQPTHLRPFLMDVKERPRERTGRVDLHLPDAEGPRPAVVFVHGGPVPAGARPTPRDWPAFVGYAQYAASLGAVGVTVDHRLHELTAYGRAADDIAGAIELVRADPRVDGDRVALWFVSAGGLLAADWLGAPPSWLRCVAASYPILAPLPGWGIADSRFRPAAAVRGAGRLPIVLTRVGLERPEIAVTVEEFVSAAADCGAALEVIDVPLGHHGFETIDPTDESRDAVRRAMRSVLGHLGAGTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-09-29" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JXT9</accession>
    <name>A0A2M9JXT9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Bleomycin resistance protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_12515</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN11684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN11684">
        <property type="protein sequence ID" value="PJN11684"/>
        <property type="gene ID" value="CG723_12515"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041581">
        <property type="entry name" value="Glyoxalase_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18029">
        <property type="entry name" value="Glyoxalase_6"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VOC" evidence="1">
        <location>
            <begin position="23"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN11684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="273" mass="28453" checksum="3363285A5DBA3245" modified="2018-04-25" version="1">MTDRLATEAGDEDGPPSGAVLGAPCWVSLAAHDLAATTAFYEAVLGWEFRPGRLGDRFAVAMANGRPVAGIGAVASALGVATAWLPYFAVGDPDETASRVRERGGTVGVGPIPFPLGRAALVADSSGAAFGIWSGHVERDWSGCHPEAQVRLRLVTRNAFDAAIFYGEVLGWTGPGGCDVRYENEEVVLVCGGLSMARISSGAVEAAPDPDVRPHWEVQFTVDDVAECTRAALKQDGTVVGEWEDEAGRWAAVRDAQGAPFTVFEPGGGVLAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JXU5</accession>
    <name>A0A2M9JXU5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Histidine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_12610</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN11699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN11699">
        <property type="protein sequence ID" value="PJN11699"/>
        <property type="gene ID" value="CG723_12610"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00038">
        <property type="entry name" value="CAP_ED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018490">
        <property type="entry name" value="cNMP-bd-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000595">
        <property type="entry name" value="cNMP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51206">
        <property type="entry name" value="SSF51206"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Histidine kinase" evidence="2">
        <location>
            <begin position="300"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="473"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="479"/>
            <end position="495"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN11699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="495" mass="54471" checksum="F9CC9ED847DDF44A" modified="2018-04-25" version="1">MNGRRVPCSREELGSLFLFEKLDADQLDRLCREGHVEAFDPGPVYGESDPATCFYVLLEGELVLSRRVGADDVEVNRSSSRGVYSGAFQSYLGDRAPQTYNSSMRVTEPSRFFVLPADTFAAVVREWFPMAVHLLEGVFFGVRSAQQRIGQRERLLALGSLSAGLTHELNNPAAAAARATSSLRERVAGMRHKLGAIAAGPYRRATLETLIEIQERTAEQVSKTPALTPLETSDREDALTDWLDDHGITDGWQLAPNFVQAGLDNDWLDQVASAVGEETLEGAVRWLNYTVETELLMNEIEDSTARISHLVDAAKQYSQLDRAPSRFADVHELLDSTLMMLSGKFGHGIKVVKDYDRTLPEVPAYPGELNQVWTNLIDNAVSAMNDAGGEGTLTVRTALDRDLLLVEFRDTGPGIPADIRGRIFDPFFTTKPVGEGTGLGLDISWRIVVNKHHGQLDVHSEPGDTRFQVHLPLASTNSDPEPVPDPVPDPPQEPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JXV9</accession>
    <name>A0A2M9JXV9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_12690</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LysR transcriptional regulatory family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN11715.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN11715">
        <property type="protein sequence ID" value="PJN11715"/>
        <property type="gene ID" value="CG723_12690"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005119">
        <property type="entry name" value="LysR_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000847">
        <property type="entry name" value="Tscrpt_reg_HTH_LysR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00126">
        <property type="entry name" value="HTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03466">
        <property type="entry name" value="LysR_substrate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00039">
        <property type="entry name" value="HTHLYSR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50931">
        <property type="entry name" value="HTH_LYSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH lysR-type" evidence="2">
        <location>
            <begin position="3"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN11715.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="297" mass="31386" checksum="B4880CDA0307B2F4" modified="2018-04-25" version="1">MTVNLSQLRAFLAVVDAGGFSAAAAELGLSQSAVSHAVASLERELTAPLLVRATPVRTTALGERVVPHARTAVAATRSVEQLASDAATMTGTVRLAATPTVCQGLIPGLLRHWGEDQPRVTVRVFEGDSSEIAGWLENGTADAAILIDPPPGPGIQLAADDYRAVLPLDHPLAGEPVVDIRDLEDDPFLISPNGCEDRIRTIHRLAGLRFTPTHRVRDLATLISMVQAGIGVTVLSEVSRSLIPPDLALLPLHPQTSRRLVLTGPRARPWKPAVRTLADSALDHLAAAGAMSDTRTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JY80</accession>
    <name>A0A2M9JY80_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CG723_12825</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CB01635</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN11737.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN11737">
        <property type="protein sequence ID" value="PJN11737"/>
        <property type="gene ID" value="CG723_12825"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004673">
        <property type="term" value="F:protein histidine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033463">
        <property type="entry name" value="sCache_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029151">
        <property type="entry name" value="Sensor-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01590">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13581">
        <property type="entry name" value="HATPase_c_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17203">
        <property type="entry name" value="sCache_3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07228">
        <property type="entry name" value="SpoIIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00065">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00331">
        <property type="entry name" value="PP2C_SIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103190">
        <property type="entry name" value="SSF103190"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="SSF81606"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="37"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="199"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="domain" description="PAS" evidence="4">
        <location>
            <begin position="239"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PJN11737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="926" mass="98283" checksum="579EC5BD2C709079" modified="2018-04-25" version="1">MTQSLGRPAARQEGTVFGAPRPSWGQSLRSLVSVHSVAGQVFLLQLTLTVLLVVAAGAALVLQTRDSSMREARQSSAATAEAFAHSPGTLSAMKSADPSAALQPSAEAVRKATGVDYVVTFNTAGIRWSHPDPSLIGKRVIGSFAHALAGHMITSTFNTSVGPAVNTTVPVIDTDGSVVGLVSVGITVENVNAGVSHRLPMLLGSAAGALLVVTAGSVLVSRRVRRQTHGLDPAELSRMYEHHDAVLHAVKEGVLITSGDGRLLLANDEAKRLLGLPPGAEGRAIADLGLAPHMAELLVAEQVVTDEVHRAGDRLLAVNVRPTALYGGPAGNAVTLRDSTELRALAGKAQSARERLQLLYDAGVRIGTTLDVIHTAEELADVAVPRFADVVTVELLDGVIGGGEPSGDTTEMRRAAVTGISRKDVFHPVGELIRFAPATPMALSMSDGRAVLEGDLRAVGGWRTQDPERARRILEHGVRSLISVPLSARGVVLGLADFWRMESTGPFEPDDLSTAEELAARAAVAIDNARRFTREHAMAVTLQRSLLPGALPEQSALQVAHHYLPAEAGVGGDWFDLIPLPGARVALVVGDVVGHGVRAAATMGQLRTAVHNFSSLDLTPDELLSHLDEQVARIDADVAREGDGAGIVGATCLYAIYDAVTGHVTMASSGHPGPAVVRPDGTVTLLDVPVSPPLGLGDGMPMETLELRLPEGSQLVLYTDGLIEGRHRDFDTGIELLRAALSNGANRTPQETCTDVLDAVMPERPDDDVALMVARTRLLDPSRVTEWDVPSDPAAVAPVRSACLRQLDDWDLDGIAFTTELILSELITNAIRHGTQPIKVRMLYDRTLICEISDGSSTAPHLRRAATTDEGGRGLFLVAHYAERWGTRYPPRGKVIWAELSPYGGDEELVPDLGDDFLEQWVEPEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-09-29" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JYB8</accession>
    <name>A0A2M9JYB8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CG723_13655</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CB01635</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN11870.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN11870">
        <property type="protein sequence ID" value="PJN11870"/>
        <property type="gene ID" value="CG723_13655"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="21"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="51"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="84"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="108"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="146"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="178"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="244"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="278"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="312"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="335"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="365"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="399"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="18"/>
            <end position="423"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PJN11870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="441" mass="46715" checksum="F9FEA04E070FC9E8" modified="2018-04-25" version="1">MNTVSTVENVRRKVSRRLLPPLFLMFVLSFLDRTNVALVKPHLEADVGIDAAAYGLGAGVFFVGYAVLGVPSNLALHRIGARRWLAGLMFVWGLLSCAMALVNSPTSFYALRFLLGAAEAGFFPGVILYITYWFPAADRGKATGMFQSAVAISSIIGNPLGGYLIGLHGLAGLDGWKWMFLLEGAPTVLLAIAVPWLLTDRPEQASWLTSEEKVLLTDRIAADRPDPSMRSPQRARAIISDSRVLRLMFVYFAIQISVYGVTFWLPALVGRIDGLGDVGIGFVSALPWVFALLGVVILPWYSDRTGDRRGPLRLALVLTVAGLLGGVLLPPVPAVAALCVAAFGFLGAQPVFWTVPPTILAGIQIAGTIPLISGFGNLGGFVGPYVMGAVESGTGSGAGGLYVIAAIAAAGAVVATGFHWVGQTTRTPAEGNENDAHRALR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JYM9</accession>
    <name>A0A2M9JYM9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CG723_14270</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN11975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN11975">
        <property type="protein sequence ID" value="PJN11975"/>
        <property type="gene ID" value="CG723_14270"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PJN11975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="175" mass="18393" checksum="9E72B55993ECB250" modified="2018-04-25" version="1">MAMVGLFWIAEGDVYVGAKPSGLATGVRLTPEGVVGLGEGQSALYLWEDVTALTVADVPVKSLMRQVGVVKDLALAAVTELALPVSSGRIDEAPPLMAVHVESSDGDHELAAYVAAAVGYPQTEVDLSRALLSRLTQGAATMETTLAAMSAWGRTWEGGSPRSSQREQLLREWAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JZA1</accession>
    <name>A0A2M9JZA1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Amino acid permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CG723_13150</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CB01635</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN12199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN12199">
        <property type="protein sequence ID" value="PJN12199"/>
        <property type="gene ID" value="CG723_13150"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004841">
        <property type="entry name" value="AA-permease/SLC12A_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00324">
        <property type="entry name" value="AA_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="25"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="63"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="104"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="145"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="171"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="210"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="249"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="309"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="355"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="387"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="423"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="457"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="domain" description="AA_permease" evidence="6">
        <location>
            <begin position="43"/>
            <end position="450"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PJN12199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="484" mass="49901" checksum="4589BFEDFC600CD6" modified="2018-04-25" version="1">MDSQTVTRQQTVQDPPTAGKLKSNALGVVGILFFVLSAQAPLTGIAGALPISVGLGNGAGAPAGYAVAGAVIFLFSVGFVAMGRHVVDAGAFYTYIGRGLGRTTGTGSAGVALFAYCTIQAAMYGLYGSIVSGLVAQYTGLDAPWWVWAVVTMVIVQVLGAAGIEMGAKVLAVFVLAEFSILLVFALVTLVKGGGPEGLGFAESFSPKAALQGAPGVALMFAVASMFGFEATAIYGEEAREPKKTVPRATYLSVAVVTGFFAFTSWMLVSAYGASHATAAAGKALAGGDGVVFVLSPVADLFGGWAGDVLPVLLATSLFAGILAFHNSANRYLFSLGREGVLPRRLCTLNRCHSPWAAGTVQTTLALLLVVPFALLGKDPVLSLFSWFSGVAVLAMMLLYFLTSVSVIVFFRRERLDTRPWNTLIAPALGALGIGGAIWVILANFTTLIGGSAETATWLVLSVPAVLVLSAVAARAVRARAATA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JZD1</accession>
    <name>A0A2M9JZD1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">SARP family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CG723_14290</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CB01635</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AfsR/DnrI/RedD regulatory family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN12229.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN12229">
        <property type="protein sequence ID" value="PJN12229"/>
        <property type="gene ID" value="CG723_14290"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043531">
        <property type="term" value="F:ADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd15831">
        <property type="entry name" value="BTAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005158">
        <property type="entry name" value="BTAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002182">
        <property type="entry name" value="NB-ARC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03704">
        <property type="entry name" value="BTAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00931">
        <property type="entry name" value="NB-ARC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01043">
        <property type="entry name" value="BTAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0902">Two-component regulatory system</keyword>
    <feature type="domain" description="OmpR/PhoB-type" evidence="4">
        <location>
            <begin position="1"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="3">
        <location>
            <begin position="1"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PJN12229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="973" mass="105898" checksum="DE14608FFBC05A98" modified="2018-04-25" version="1">MLGPLRAWRGETPLDLGPAKRQAVLAALLLRHGAVVSHERLLDGVWGADPPATGHKVLASHVNPLRRALDAAGTRPAESVILSGKGWYRCAADFIRLDVADLAPRGDEALRTKASGDLPSAADQLSAALALFQGEPLANLPGPFAQAERQRLLERRRTLRLARLECLVLLGRFADALDDLACLPESDRYDESLMALRMRALYSCERQAEALNAYEDLRVRLRDELGVDPGEELSRIHDAVLRQDNAFLLGPAAGPATAPDRSRLRPAVNQLPGDTGQLVGREDELALLTVSCEPDSVSVVAVDGPAGVGKTALVVRAAQHIRDRYPDGCLFVDLHAHSTARQKLSPQRVLRRLLRSIGADDREVPNDLDELMTHWRTATSSLRLLLVLDDTLGTRQVQPLLPAGPGSSVIVASRQRLPALDADRRVTLDTLGTGDATRLIRHIVGPERTDQEPEATGELVRMCDGLPLALRIAGTRLQTRPAWTLAYLVERMTGDAHRLGELSAGDRSVEAAFRLSYEQLSPTQQQGFRTLGLAPTVEFDLRTPAAMLGWSPQDAELVLESLVDTSLLQQPRPGRYRMHDLVRVHARRLAETAAAETGAARRASLRLYLDAARIASAWGSDAFPNGPQPAGAPFTQWRDATLWLDSAGAELVDVVGHAAAFGEADYACWIAEALTGHFLSRRRFHECQTALEIALTQADRATDRRMELSLRNALGLTLMHRARFPEALTCLDQALALSREREDGREEARALVGLGAMAGLGTAGPSTERGRQGASWLASGLALAQQCDDHWLAAMASFALGLVHHAQGHHEEALACFRTAFAPSMILGHPRAINRALTSTLDLYLYLDRPGTQTLLRQVASLIQETGDVPLHTLTLTRLGTAEHSAGNLSAASAAYQHALAQHRTLAPRDDPDHGRNEMDIRCRLGHSYYAAGRITDARDQFRTALAIPGAARYPREHAQAVEGLSRSETLEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JZN3</accession>
    <name>A0A2M9JZN3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CG723_04605</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000002">
        <property type="protein sequence ID" value="PJN12339.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN12339">
        <property type="protein sequence ID" value="PJN12339"/>
        <property type="gene ID" value="CG723_04605"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021412">
        <property type="entry name" value="DUF3052"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11253">
        <property type="entry name" value="DUF3052"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PJN12339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="145" mass="15732" checksum="3F767F172EAE2F9E" modified="2018-04-25" version="1">MSATADHAEERTNPAARLGFQPEQVVQEIGFDDDVDQELRESIEEVIGSELVDEDYDDVADAVVLWFREDDGDLTDALVDASQLVDDGAPVWLLTPKTGRDGYVEPSDINEAAQTAGLSQTKSINAGKDWAGSRLVTPKAAAKKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JZN7</accession>
    <name>A0A2M9JZN7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DUF4383 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_04680</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000002">
        <property type="protein sequence ID" value="PJN12352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN12352">
        <property type="protein sequence ID" value="PJN12352"/>
        <property type="gene ID" value="CG723_04680"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025492">
        <property type="entry name" value="DUF4383"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14325">
        <property type="entry name" value="DUF4383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="34"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="75"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="101"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="132"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="169"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="169"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN12352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="218" mass="23469" checksum="4075B88C80B8B613" modified="2018-04-25" version="1">MATHISENRPAPRFRHQRVILDDHLPVDHSLSKVYRIGAGLMGLVLVAFGILGLIDQIGFFDTGGDKIAGLNTNGALSVLSILVGALLFAGMVIGRNVASTINLTVGILFILSGFVNLALLQTDYNFLAFEIQNVLFSFVVGVMLMAFGMYGRVSGTLPHDNPYWRARHPESAAREDRARAARQPHPTPEVAKAPGVTGATETTKITDGPGPPRIIDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K0F4</accession>
    <name>A0A2M9K0F4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CG723_06160</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000002">
        <property type="protein sequence ID" value="PJN12612.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN12612">
        <property type="protein sequence ID" value="PJN12612"/>
        <property type="gene ID" value="CG723_06160"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="3">
        <location>
            <begin position="9"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="225"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="234"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PJN12612.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="260" mass="27658" checksum="FE05F9794BAF89E9" modified="2018-04-25" version="1">MDGPNAVAVSAERFGLKGPRGWAFRGVDIDAEPGALVAVEGPSGSGRTCLLLALTGRMRPTEGAASVGPFRLPKQLSAVRRISALAHVPGVTDLDPALTVEEHLRERALLQRRFDGSLRTLLRPRAERAAASRLRIDTALAAAGLDREALPKGTRTAVRDLERIEALRLSVALALIGRPRLLGVDDTDLKLSDAERTQVWDLLRSVAESGTTVVAVCSEAPKDAVVVSTAPRDEADEQSPENPETDKKETADALAEAGRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K0K9</accession>
    <name>A0A2M9K0K9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_06510</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000002">
        <property type="protein sequence ID" value="PJN12673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN12673">
        <property type="protein sequence ID" value="PJN12673"/>
        <property type="gene ID" value="CG723_06510"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.4080.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005502">
        <property type="entry name" value="Ribosyl_crysJ1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036705">
        <property type="entry name" value="Ribosyl_crysJ1_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03747">
        <property type="entry name" value="ADP_ribosyl_GH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101478">
        <property type="entry name" value="SSF101478"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="17"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN12673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="471" mass="50712" checksum="AE214B89643997C2" modified="2018-04-25" version="1">MLRLTWVQPEDLLGHELRQAAQEGRNASGVERRWREAGGHPPPERAGASPPPQDPKLRPLAQQLLDELASTQSPLRALEPTSLPEIRQLTPHPARPTLEDKERGSLGAAPPETSEAKGLHASWLGRAVGCLLGKPVEKLPLRGIRAIAKSTSNWPLSTWFTHRNLPQDVAERYPWNRRSRPTSLAENIDGMPEDDDLNYPLLGLLLLQRHGADFTTADVAQLWLDELPAGRTFTAERVAYRNLLDGIEPPDTAVHHNPFREWIGAQIRADIFGWTNPGDPAGAAELAHRDATLTHTANGVYGEMFVAAAIAHASAPSGTAPTVQATLDAALSVIPPDSRYAQAVRFGIETARAEPTGTPAGFASVVDTLHARYAHDHHWVHVLPNAALLAAALTHADGDFTGSICRAVSGGWDTDSNGATAGSIAGLLAGSPDAIDDRWTAPLKNRLSTSVADFDGIGFDELARLTLEART</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K0R3</accession>
    <name>A0A2M9K0R3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Branched-chain amino acid ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CG723_06840</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CB01635</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000002">
        <property type="protein sequence ID" value="PJN12725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN12725">
        <property type="protein sequence ID" value="PJN12725"/>
        <property type="gene ID" value="CG723_06840"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001851">
        <property type="entry name" value="ABC_transp_permease"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02653">
        <property type="entry name" value="BPD_transp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="63"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="97"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="149"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="195"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="236"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="279"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PJN12725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="309" mass="32540" checksum="B853B1093F84312C" modified="2018-04-25" version="1">MNTLPQQLANGLFLGSMYGLIAIGYTMVYGIVQLINFAHGEIFMTGGFGALTVYLALPDGISMWIALPAMLIGGALVATLIAVGAERFAYRPLRGAPRLAPLITAIGLSLALQQAVFNWYPDAKSARVFPQLPFGPYHLGDIRIQSGDVFLIIAAPLCMAALAFFVRLSRTGRAMQATAQDPDTSQLMGIDTNRIIVIAFAIGGIFAAVAGVAYGLKYGSVQYDMGFQAGLKAFTAAVLGGIGNIYGAMLGGVVLGLAEAMATAYVADIPGMEQFGGQGWASVWAFVLLILVLLLRPQGLLGERVADRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K0T8</accession>
    <name>A0A2M9K0T8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CG723_06860</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CB01635</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mo-bis(molybdopterin guanine dinucleotide)</name>
            <dbReference type="ChEBI" id="CHEBI:60539"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the prokaryotic molybdopterin-containing oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000002">
        <property type="protein sequence ID" value="PJN12729.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN12729">
        <property type="protein sequence ID" value="PJN12729"/>
        <property type="gene ID" value="CG723_06860"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008863">
        <property type="term" value="F:formate dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030151">
        <property type="term" value="F:molybdenum ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043546">
        <property type="term" value="F:molybdopterin cofactor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02787">
        <property type="entry name" value="MopB_CT_ydeP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02767">
        <property type="entry name" value="MopB_ydeP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009010">
        <property type="entry name" value="Asp_de-COase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037951">
        <property type="entry name" value="MopB_CT_YdeP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006657">
        <property type="entry name" value="MoPterin_dinucl-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006656">
        <property type="entry name" value="Mopterin_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010046">
        <property type="entry name" value="Mopterin_OxRdtse_a_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041953">
        <property type="entry name" value="YdeP_MopB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43105:SF4">
        <property type="entry name" value="PTHR43105:SF4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00384">
        <property type="entry name" value="Molybdopterin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01568">
        <property type="entry name" value="Molydop_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50692">
        <property type="entry name" value="SSF50692"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01701">
        <property type="entry name" value="Fdhalpha-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Molybdopterin" evidence="6">
        <location>
            <begin position="120"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="domain" description="Molydop_binding" evidence="7">
        <location>
            <begin position="654"/>
            <end position="761"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="612"/>
            <end position="631"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PJN12729.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="771" mass="83680" checksum="859A43741A695214" modified="2018-04-25" version="1">MATKPPTGDPVQDAPQVGAPRRAAAGLPAVAHSLKIAQQQMGVRRTALTLLRVNQKDGFDCPGCAWPEPDHRHKAEFCENGAKAVAEEATLRRVTPDFFAAHPVADLATRSGYWLGQQGRLTHPMYLADGAERYEPVSWERAFDIIAEELAALASPDEAVFYTSGRTSNEAAFLYQLFAREFGTNNLPDCSNMCHESSGSALTETIGIGKGSVLLEDLYKSDLIIVAGQNPGTNHPRMLSALEKAKENGAKIITINPLPEAGLERFKNPQTPQGMFKGAALTDLFLQIRLGGDQALFRLLNKLILAESDSASGAGSGAVDHAFIEEHTHGFEEFAAAARAADWDTTLTATGLERAEIEEALSLVLASKRTVVCWAMGLTQHKHSVPTIREVVNFLLLRGNIGRPGAGVCPVRGHSNVQGDRTMGVFERPAPAFLDALEKEFGFAPPRKHGFDVVRAIEALRDGEAKVFFAMGGNFVAASPDTDVTEAAMRRAALTVHVSTKLNRSHAVTGARALILPTLGRTERDVQGSGEQFVTVEDSMSMVHASRGRLAPASKHLLSEPAIVARLARRVLGEASRTPWEEFEKDYATVRDRIANVIPGFEDFNARVTGSAGRPGGFTLPHGPRDERRFPTTTGKANFTAAPVEYPKLPEGRLLLQTLRSHDQYNTTIYGLDDRYRGIKNGRRVVLVSPHDAQDLGLADGSYVDLVSEWTDRVERRAPGFRVVHYPTARGCAAAYYPETNVLIPLDATADTSNTPTSKSVVVRLEQSATD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K1A0</accession>
    <name>A0A2M9K1A0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CG723_07770</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CB01635</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000002">
        <property type="protein sequence ID" value="PJN12896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN12896">
        <property type="protein sequence ID" value="PJN12896"/>
        <property type="gene ID" value="CG723_07770"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007343">
        <property type="entry name" value="Uncharacterised_pept_Zn_put"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30168">
        <property type="entry name" value="PTHR30168"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04228">
        <property type="entry name" value="Zn_peptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="27"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PJN12896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="292" mass="31833" checksum="3146A1D3E9248FF2" modified="2018-04-25" version="1">MQFDDDADLDTSEVQDRRRVPGGRRTIGGGLAGLLALLVGLFFGTDEFGLSSGGGEPDATVSSAAQVSQDCRTGQDANSKEDCRIVAVVNSVQDYWRQEFRDRRGTYSPAQTVFFTGQVQTACGTATSAVGPFYCPGDRKVYLDLGFFNDLRTKFGSSGGPFAQAYVVAHEYGHHVQNLMGTLQRSQDGRTGQNSNAVRVELQADCYAGVWAHHATTTPDDKTGKPLITNLTDADIRDGLGAAAAVGDDRIQEKFQGRVTPESWTHGSAQQRQEWFYEGYRTGDMARCNTFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K1X3</accession>
    <name>A0A2M9K1X3_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Hydrogenobyrinate a,c-diamide synthase</fullName>
            <ecNumber evidence="3">6.3.5.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Hydrogenobyrinic acid a,c-diamide synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">cobB</name>
        <name evidence="7" type="ORF">CG723_07705</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CB01635</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of hydrogenobyrinate, using either L-glutamine or ammonia as the nitrogen source.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>2 ATP + 2 H2O + hydrogenobyrinate + 2 L-glutamine = 2 ADP + 2 H(+) + hydrogenobyrinate a,c-diamide + 2 L-glutamate + 2 phosphate</text>
            <dbReference type="Rhea" id="RHEA:12544"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:77873"/>
            <dbReference type="ChEBI" id="CHEBI:77874"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.5.9"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 3">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Cofactor biosynthesis; adenosylcobalamin biosynthesis; cob(II)yrinate a,c-diamide from precorrin-2 (aerobic route): step 9/10.</text>
    </comment>
    <comment type="domain">
        <text evidence="3">Comprises of two domains. The C-terminal domain contains the binding site for glutamine and catalyzes the hydrolysis of this substrate to glutamate and ammonia. The N-terminal domain is anticipated to bind ATP and hydrogenobyrinate and catalyzes the ultimate synthesis of the diamide product. The ammonia produced via the glutaminase domain is probably translocated to the adjacent domain via a molecular tunnel, where it reacts with an activated intermediate.</text>
    </comment>
    <comment type="miscellaneous">
        <text evidence="3">The a and c carboxylates of hydrogenobyrinate are activated for nucleophilic attack via formation of a phosphorylated intermediate by ATP. CobB catalyzes first the amidation of the c-carboxylate, and then that of the a-carboxylate.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CobB/CbiA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.9" evidence="3"/>
    <dbReference type="EMBL" id="NNBL01000002">
        <property type="protein sequence ID" value="PJN13027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN13027">
        <property type="protein sequence ID" value="PJN13027"/>
        <property type="gene ID" value="CG723_07705"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00148">
        <property type="reaction ID" value="UER00220"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042242">
        <property type="term" value="F:cobyrinic acid a,c-diamide synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043802">
        <property type="term" value="F:hydrogenobyrinic acid a,c-diamide synthase (glutamine-hydrolysing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009236">
        <property type="term" value="P:cobalamin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00027">
        <property type="entry name" value="CobB_CbiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004484">
        <property type="entry name" value="CbiA_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002586">
        <property type="entry name" value="CobQ/CobB/MinD/ParA_Nub-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011698">
        <property type="entry name" value="GATase_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43873">
        <property type="entry name" value="PTHR43873"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01656">
        <property type="entry name" value="CbiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07685">
        <property type="entry name" value="GATase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0169">Cobalamin biosynthesis</keyword>
    <keyword evidence="2 3" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CbiA" evidence="5">
        <location>
            <begin position="8"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="domain" description="GATase_3" evidence="6">
        <location>
            <begin position="295"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="253"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="3">
        <location>
            <position position="377"/>
        </location>
    </feature>
    <feature type="site" description="Increases nucleophilicity of active site Cys" evidence="3">
        <location>
            <position position="471"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF07685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PJN13027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="501" mass="51349" checksum="9572AA915E228626" modified="2018-04-25" version="1">MSSSLPRLVIAAPSSGSGKTTVATGLMAAFAGRGLAVSPHKVGPDYIDPGYHALATGRAGRNLDAYMCGPELVAPLFAHGARGCDLAVVEGVMGLFDGASGQGELASTAHVAKLLRAPVVLVVDASSQARSVAALVHGFASFDPEVRLAGVILNKVGSDRHEAILREALDESGVPVFGALRRGGEVVTPSRHLGLVPVAERGAEAVAAVAAMAELVRVGCDLDALHAVARGAGPLDCAAWDAAEVLGSLPRPAPSRPYQYAAPPRGGSAPDPGPQTQDGPDAPELPDRKGGKPRVAVAGGAAFTFSYAEHSELLAAAGADVVSFDPLRDEQLPDGTQALVIGGGFPEVYASELSANEPLRKAVGELARSGAPVVAECAGLLYLARSLDGRPMCGVLDIDARMSERLTLGYRDAVAVSDSVLAANGTRVRGHEFHRTVVEPGAGASPAWGITRPGRRVEGFVQGGVHASYLHVHWAAVPQAARRIVAQATEVARATEGVTPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K384</accession>
    <name>A0A2M9K384_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Succinate--CoA ligase [ADP-forming] subunit beta</fullName>
            <ecNumber evidence="6">6.2.1.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Succinyl-CoA synthetase subunit beta</fullName>
            <shortName evidence="6">SCS-beta</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">sucC</name>
        <name evidence="9" type="ORF">CG723_03190</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CB01635</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>ATP + CoA + succinate = ADP + phosphate + succinyl-CoA</text>
            <dbReference type="Rhea" id="RHEA:17661"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57292"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.2.1.5"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="6">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="6">Carbohydrate metabolism; tricarboxylic acid cycle; succinate from succinyl-CoA (ligase route): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Heterotetramer of two alpha and two beta subunits.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the succinate/malate CoA ligase beta subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.2.1.5" evidence="6"/>
    <dbReference type="EMBL" id="NNBL01000001">
        <property type="protein sequence ID" value="PJN13579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN13579">
        <property type="protein sequence ID" value="PJN13579"/>
        <property type="gene ID" value="CG723_03190"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00223">
        <property type="reaction ID" value="UER00999"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004775">
        <property type="term" value="F:succinate-CoA ligase (ADP-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.261">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00558">
        <property type="entry name" value="Succ_CoA_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013650">
        <property type="entry name" value="ATP-grasp_succ-CoA_synth-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005811">
        <property type="entry name" value="CoA_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017866">
        <property type="entry name" value="Succ-CoA_synthase_bsu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005809">
        <property type="entry name" value="Succ_CoA_synthase_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016102">
        <property type="entry name" value="Succinyl-CoA_synth-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11815">
        <property type="entry name" value="PTHR11815"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08442">
        <property type="entry name" value="ATP-grasp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00549">
        <property type="entry name" value="Ligase_CoA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001554">
        <property type="entry name" value="SucCS_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52210">
        <property type="entry name" value="SSF52210"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01016">
        <property type="entry name" value="sucCoAbeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01217">
        <property type="entry name" value="SUCCINYL_COA_LIG_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 6 9" id="KW-0436">Ligase</keyword>
    <keyword evidence="5 6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 6 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 6" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="ATP-grasp" evidence="8">
        <location>
            <begin position="9"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding; shared with subunit alpha" evidence="6">
        <location>
            <begin position="308"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="45"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="52"/>
            <end position="54"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="94"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="99"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="187"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="201"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="251"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared with subunit alpha</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00558"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PJN13579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="376" mass="39286" checksum="88D51B5C63B407C8" modified="2018-04-25" version="1">MDLYEHQARELFEEHGILVPKAEVTDSPKEAREIARRLGGRVVVKAQVKTGGRGKAGGVKLAADPPAAELTARQILGMDIKGHTVGRVMLAQPVDIESEFYVSYVLDRAAGRFLAIASAEGGMDIEEVAATRPEAVARIPIDPAEGVTTAKAAQIAEAAGLPDRTVDVLVRLWDVLIREDAVLVEVNPLVRTSDGQILALDGKVTLDDNARFRQERWGTQESAHDDALEAAAAAKGLNYVKLDGEVGIIGNGAGLVMSTLDVVAGCGARPANFLDIGGGASAQIMADGLSVILSDPAVKSVFVNVFGGITACDAVADGIVQALESVRLTKPLVVRLDGNSAVQGRAILDGRAHPLVEQATTMDGAARRAAELANAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K3A1</accession>
    <name>A0A2M9K3A1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CG723_03360</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000001">
        <property type="protein sequence ID" value="PJN13606.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN13606">
        <property type="protein sequence ID" value="PJN13606"/>
        <property type="gene ID" value="CG723_03360"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PJN13606.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="204" mass="21530" checksum="7FD2194FA1BE48CF" modified="2018-04-25" version="1">MLELSQDTGVTLPDGAGAVRFGMTPDEVLSQLTEGAITRRRQCMTLTREQYPELRHAHDAWLNNLLHEPDWAFEAEFDGVTLGFSGGGPGAADRLSRLDVTTTVPAPATPVAWDDIDLFGYPAGEVAEALPEATRLSDGPAAGAGRTASGLVVETAGLRLSLLTPAAVGQRVVLLGPDARSWQACCDGAWECAKEGDALTGIMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K3D4</accession>
    <name>A0A2M9K3D4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">N(G),N(G)-dimethylarginine dimethylaminohydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CG723_03530</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CB01635</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DDAH family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000001">
        <property type="protein sequence ID" value="PJN13633.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN13633">
        <property type="protein sequence ID" value="PJN13633"/>
        <property type="gene ID" value="CG723_03530"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033199">
        <property type="entry name" value="DDAH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12737">
        <property type="entry name" value="PTHR12737"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Proton donor" evidence="3">
        <location>
            <position position="163"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="3">
        <location>
            <position position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR633199-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PJN13633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="258" mass="27373" checksum="134268720C819F9E" modified="2018-04-25" version="1">MPSQKALIRRPGPRLADGLVTHVERTPVDPELALTQWEAYVAALGEHGWETVEVGAADECPDAVFVEDAVVMYRNVALITRPGAASRRAETAGIEEAVARLGCSVNRVREPGTLDGGDVLKVGDTIYVGRGGRTNADGVRQLRAVFEPLGARVVAVPVSKVLHLKSAVTALPDGTVVGHEPMVDVPSLFPRFLPVPEEAGAHVVLLGGGKLLMAASAPRTAELYADLGLEPVLVDIGEFEKLEGCVTCLSVRLRELHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K3Q8</accession>
    <name>A0A2M9K3Q8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Sugar ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CG723_01535</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CB01635</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000001">
        <property type="protein sequence ID" value="PJN13749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN13749">
        <property type="protein sequence ID" value="PJN13749"/>
        <property type="gene ID" value="CG723_01535"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="74"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="108"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="141"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="182"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="241"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="70"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PJN13749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="277" mass="29980" checksum="F68B916FD5C9D9AE" modified="2018-04-25" version="1">MRPSRPARAGQYLALLAYLVFLAFPFLWLISTAFKPPRELASLHPTWIPKDPTLANFRQAFDEQPLLRAAVNSVIVAVCAALIAVVIATPMAYVMARHRSALSRAATGWVVVSQAFPFVLLIIPLFLILKNLHLINSLPGLTMVYVVWSLPFALWMLVGYVRAVPPELEEAAAVDGAGKLRTLVSVTAPLLAPGLVATALFAFITAWNEFFFALVLMKTPERQTLPVILTHFLGAEGVADLGPLAAAAFLATLPSLVIFALIQRRLTGGMLTGAVKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K3R2</accession>
    <name>A0A2M9K3R2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Sensor histidine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_02355</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000001">
        <property type="protein sequence ID" value="PJN13768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN13768">
        <property type="protein sequence ID" value="PJN13768"/>
        <property type="gene ID" value="CG723_02355"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011712">
        <property type="entry name" value="Sig_transdc_His_kin_sub3_dim/P"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07730">
        <property type="entry name" value="HisKA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="49"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="79"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="104"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="138"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="163"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="domain" description="HisKA_3" evidence="2">
        <location>
            <begin position="218"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN13768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="421" mass="45233" checksum="11621E75E46DFE1B" modified="2018-04-25" version="1">MEVQELTGTTPPGERYRWRRRMLPSAVADELDLDPDGRPGRRRRTLRDWVVDFTCFLVAVGIGLLGAHSVTNDPNTSDGLAALDQWLGALACAAVWLRRRWPLGLAIALAAVSMVSNSAGGATMVAIFTLAVHRPFRYVAWVAGASCALIPFFFWIRPDPDSPYVLSVTFTIVLTVTVVGWGMFVRSRRQLLLSLRDRARRAETEAGLRAEQAQRLAREAIAREMHDVLAHRLTLLSVHAGALEFRPDAPRQEVARAAGVIRESAHEALQDLREIIGVLRADDHGEESGRPQPTLAGLDALVAESREAGMKIVLDHQVTAPDAVPASVGRTAYRIVQEGLTNARKHAPGAEVEVLVTGAPGDGVTVSVRNPPPPGEVPHVPGSGQGLIGLTERATLAGGSLGHGAADDGGFAIEAWLPWPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K3S1</accession>
    <name>A0A2M9K3S1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uracil permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CG723_02165</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CB01635</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000001">
        <property type="protein sequence ID" value="PJN13762.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN13762">
        <property type="protein sequence ID" value="PJN13762"/>
        <property type="gene ID" value="CG723_02165"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015205">
        <property type="term" value="F:nucleobase transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006043">
        <property type="entry name" value="NCS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017588">
        <property type="entry name" value="UacT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006042">
        <property type="entry name" value="Xan_ur_permease"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00860">
        <property type="entry name" value="Xan_ur_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00801">
        <property type="entry name" value="ncs2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03173">
        <property type="entry name" value="pbuX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01116">
        <property type="entry name" value="XANTH_URACIL_PERMASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="36"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="64"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="90"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="119"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="155"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="184"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="221"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="306"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="335"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="367"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="395"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="426"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="440"/>
            <end position="458"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PJN13762.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="458" mass="46663" checksum="B94490604B0ED22C" modified="2018-04-25" version="1">MATTGLQHVAAMYAGVVAPPLIVGAAVGLSPKELTFLTGACLFTAGLATFLQTLGIWKIGARLPFVNGVTFAGVAPMIAVVNSTDDKKDALPVIFGAVIVAGVLGFIAAPFFSKLVRFFPPVVTGTVITLIGVSLMPVAFGWAQGPNPAAKDYGSTTYLTLAGITLVIVLLLRRFTTGFVKQIAVLLGLIIGTLVAIPFGVTDFSPIGDADVIGFPTPFHFGAPQFAAAAIVSLCVVMVVSMTESTADMLALGEIVERPADEKTIAAGLRADTLGSALSPFFNGFMCSAFAQNIGLVAMTKIRSRYVVATGGGFLVLMGLCPMAASLIAVVPRPVLGGAGVVLFGSVAASGIQTLVKANLERDNNVLIVAVSLAVGLIPIAAPEFYHAFPETAKIILDSGISTGCVAAVILNLLFNHLGRSGDADDVTAPMEPGGEIASTRTVAGSSASAGSSAAGVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K3S2</accession>
    <name>A0A2M9K3S2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Peptide ABC transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CG723_02575</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CB01635</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000001">
        <property type="protein sequence ID" value="PJN13773.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN13773">
        <property type="protein sequence ID" value="PJN13773"/>
        <property type="gene ID" value="CG723_02575"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045621">
        <property type="entry name" value="BPD_transp_1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19300">
        <property type="entry name" value="BPD_transp_1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="101"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="134"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="178"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="282"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="95"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PJN13773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="317" mass="33087" checksum="A561E3F23617F1F9" modified="2018-04-25" version="1">MAAYVLTRVRQSVITLFLVSIVVFAGIRALPGDPALALAGEERSPAALAAIRAEYGLDDNIVIQYGRFIGHALTGDLGTSSRTGLPVSDAIGQALPVTLELAALSLLLAVVLGIGAGIVAAVRRGRPAEWIANGLALLGLSVPTFWLGMVLVLAFAIAVPVFAASGYVPFGTDPLDNLRRMVLPAIVLGSGLAAVVMRQTRAAMLDSLSADYVRTARAKGLSRREVIGGHALRNSLVTVVTVLGLQLGHLISGAVVTEQIFVLPGFGKLTIDAVFTRDYATLQGVVLCTSAAYILINLLVDVAYSVIDPRIRLGGAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JEV6</accession>
    <name>A0A2M9JEV6_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">PMT_2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CG723_44535</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CB01635</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000048">
        <property type="protein sequence ID" value="PJN05431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN05431">
        <property type="protein sequence ID" value="PJN05431"/>
        <property type="gene ID" value="CG723_44535"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038731">
        <property type="entry name" value="RgtA/B/C-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13231">
        <property type="entry name" value="PMT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="40"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="101"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="128"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="166"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="194"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="229"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="259"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="285"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="domain" description="PMT_2" evidence="10">
        <location>
            <begin position="32"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="433"/>
            <end position="456"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF13231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PJN05431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="456" mass="48962" checksum="7856358106D70CD9" modified="2018-04-25" version="1">MWGDESVTYQLAHRDLSQIWLTAQHIDLVHALYYAVMHEIFGFFGGGLLTLRLPSVLAMAVAASGVGLLGLRLAGPRAGLLAGLVFSLLPQVQKYAQEGRSYAMVCALVTWATYALVVSVPHRARWRWAVYGSTMLLACLLHEFAVLALVAHGVTLVVSRVPRPVLRAWSVAAAGVVAGLLPLAIYSAGQSEQVSWIGVPVRLRYFLVVAVVGMVCARAPLGVRGPVRLSVLAVPILVLPGLLLLIASLVKPLFVDRYVVYSNIGIALLLGACMDYFLRRQRSSRYAWIVAVAVLAALVQPSLSLRTPQSRSNDVTAIGAAVRKEGRPGDGLLHLAGQHRILTAANPEDTRLLTDLALAQDPVSSNTLAGVELPAQEIAARMLQFDRIVAVRAVGVHSPANPQEEAKTSTLRRHFREYGTTRVNGARVTVYVRDHDPSPKAGPGSNSPGASGGVMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JEY7</accession>
    <name>A0A2M9JEY7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CG723_44605</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CB01635</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000048">
        <property type="protein sequence ID" value="PJN05439.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN05439">
        <property type="protein sequence ID" value="PJN05439"/>
        <property type="gene ID" value="CG723_44605"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="44"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="74"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="104"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="136"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="162"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="201"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="225"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="265"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="302"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="332"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="356"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="468"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="7">
        <location>
            <begin position="4"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="494"/>
            <end position="554"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PJN05439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="554" mass="57213" checksum="7A0CC10A6C95DAE9" modified="2018-04-25" version="1">MPPRQVLQAVSGLVGGLFVAILAGTVVANALPRITAQLGASQSSYTWVIIAELLAMTATVPLWGKLSDLYSKKLLLQTSLGLFVVGSLVAGFSQGVGMLIFSRVVQGVGAGGLTALTQVVMAAVIPPRKLGRYSGVFGAVFSGATVAGPLIGGLLVDTSWLGWRWCFFIGVPFALLAIALLQRTLHLPHVRREVKIDWLGALLIVAGVSALLIWVSMAGSMFDWFSWQTAALVGGGTLLLAAAVRVESRAAEPIIPLSIFRNRTVALTSLASLLVGVGLFGGTVFLSQFFQVAMGKSPTTAGLMSLPLILGSLAASTFAGHRISATGRWKRYLVAGTVLMTAGLALLSTIGSHTPFVLLSVYMAVLGTGVGMLTQNLVLAAQNDVPADTLGSATSVLSFSRSMGGTVGTSVLGAVLAHRVATELAAGRTAGGDTPGGGAGHGVPDVMTPPAPLRALVENAYGIATAELFFWATPFALLALIAVLFIEEKPLKRTTSTERLAEESALAPGGRALPTPTDTPRADLAEASTKGSGGCPGTTRLLGRRPSRRASARP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JF46</accession>
    <name>A0A2M9JF46_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DPPIV_N domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_44210</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000046">
        <property type="protein sequence ID" value="PJN05525.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN05525">
        <property type="protein sequence ID" value="PJN05525"/>
        <property type="gene ID" value="CG723_44210"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011659">
        <property type="entry name" value="PD40"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002469">
        <property type="entry name" value="Peptidase_S9B_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00930">
        <property type="entry name" value="DPPIV_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07676">
        <property type="entry name" value="PD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014715267" description="DPPIV_N domain-containing protein" evidence="1">
        <location>
            <begin position="20"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="domain" description="DPPIV_N" evidence="2">
        <location>
            <begin position="163"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN05525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="306" mass="32327" checksum="1EC34F1D5BA11282" modified="2018-04-25" version="1">MAVGIVVAAGLPTAGTATAEQVTAAGQITATGYSSGSPALVSLDPVSGDVIRTFAQNAEEGVLSPKGSTVAYIQRDDTCIPQTEGCMYARNLVVADGDGSYQHVLVRGIAPETNEAPYVGHPDWSPDGKRIVYDSPRGMEWIKSDGTGQEVLTTTGGAGTFSPDGQSIAFVRTTTYETDDGWEYGRDVWVMDIATRQVRQISTARNARSTPVDWSPDGQRIVYVTENGLNAVDVATGAATELKSSWTTPLSSVQGPVFSPDGTQIAFSATDDFDSAQSTYVVDAADGKNLQVLTDQAVTPTDWLSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JF77</accession>
    <name>A0A2M9JF77_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_44240</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000046">
        <property type="protein sequence ID" value="PJN05529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN05529">
        <property type="protein sequence ID" value="PJN05529"/>
        <property type="gene ID" value="CG723_44240"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014799557" evidence="1">
        <location>
            <begin position="29"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN05529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="254" mass="27351" checksum="C7A9E97CC30343FE" modified="2018-04-25" version="1">MGKKIWRAVAAGGAAAVFTAMAAGPAGAAEGGVSFTRVQVNGGKAIVIGVSNEVAVPTSFRMATTHQWKWPAVLLYRGKTSERLWHAIETSDCIKVSSGVCDFNETMYFDPSEWEMRNSEAGAWKVAAEVYFQGGGGDTDDEGLTAYVKRNSRLTVNASPEPVAKDETITVTGKVTRANWETRKYVSYEGRLVTLQFKPTGTTSYTTVKKVYANGSGNLKTTVKASKTGTWRWVYYGNTTTGPSTSAGDNVVVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JFP6</accession>
    <name>A0A2M9JFP6_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">FAD-binding PCMH-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_43045</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000042">
        <property type="protein sequence ID" value="PJN05710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN05710">
        <property type="protein sequence ID" value="PJN05710"/>
        <property type="gene ID" value="CG723_43045"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.43.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005107">
        <property type="entry name" value="CO_DH_flav_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036683">
        <property type="entry name" value="CO_DH_flav_C_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016167">
        <property type="entry name" value="FAD-bd_PCMH_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002346">
        <property type="entry name" value="Mopterin_DH_FAD-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03450">
        <property type="entry name" value="CO_deh_flav_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00941">
        <property type="entry name" value="FAD_binding_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01092">
        <property type="entry name" value="CO_deh_flav_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55447">
        <property type="entry name" value="SSF55447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="SSF56176"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="1">
        <location>
            <begin position="1"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN05710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="289" mass="29992" checksum="5CB51C5D30A699BE" modified="2018-04-25" version="1">MKPTPFDYSAPGSVAEVLALLADEEREAKVLAGGQSLIPMLSMRLARPGLLVDITRVPGLDRLYVDASGALHIGAAVRQTRAADDPAVHDGWPLLAAAIRRIGHPQIRHRGTVCGSLAHHDPAAELPTAALALDARFVIAGPGGTRTVGAADFFVATFQTAVAPDELLTEVVLPPRAGDGWAFEELARRHGDFATVGVAVTLRRAPDRRTVAAARAVFCGAGPVPVRLPAVEEALTGTDAGAAALDAAASAALAGLTPADDVHATAAYRREAAAHLLVRACTLAWERCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-09-29" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JFQ8</accession>
    <name>A0A2M9JFQ8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DNA helicase RecD</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_43180</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000042">
        <property type="protein sequence ID" value="PJN05735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN05735">
        <property type="protein sequence ID" value="PJN05735"/>
        <property type="gene ID" value="CG723_43180"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029493">
        <property type="entry name" value="RecD-like_HHH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14490">
        <property type="entry name" value="HHH_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0347">Helicase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HHH_4" evidence="2">
        <location>
            <begin position="186"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="309"/>
            <end position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN05735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="781" mass="79147" checksum="28D90AF1A769AE14" modified="2018-04-25" version="1">MPGARRRVDARAPISRSGLEHAVSTEPAAAEGHPGPADTDAPRAGQGAEATGPEETGPEEGAGTPGPDEPDEGSGAAADQDGATAEGKDEGASEAAAEIAAQRELQERIAQRKAAKEGPIAAGGKLSGTAADLLAAVRAVESGERPAAVFSEPDPAPRKIVAEPVRRAPAAAPAGPAEPAVAAVDAVRAVLTEGGAPVSLAAPAAATLGEGADSVLRDDPWQLLRIPGVRPEQADGFARALLGAECGPDDERRGRAVTVWLLEQAAVAGHTALDAPLLAQALGKRAVPDPDEAVQSAIAEGDALVFQDALEEPPGGPASAPESARKTAAEDGAEDGSDDGHEDGEEAERPVRVLVGLERYALAEESLADGLARLVNSLSKEDSSQALADWEPAAAAASGSTAELIRASAGHGLVLHTGAEAARAEPAALVQAAARLGLRVCAAAHTVDGRRRLAEHFGPGAPEGTAVTVSGLLSGAEGPGRDRDGALAVDLLVVLDAPQLDVETAAMLAESLPDGARLVLSGDPSVLWSAGPGRVFADLLAARVCPQIASRTPDPGPVGELVSGIGVGELNQVEAPGKEVVIVPVRDAAEAIHRAVQLVADSVPRAIGVPSEQTQVITPGHGGAAGTRALNAALKERLNPGPGRFGGFDPDDRVAYAPAPGRTVPGRVVRADAQGLHLDCAGTPVVVPQDAVERTVRHGWALTAHQAVGLRWPAAVVVLPGDATQALSRPWVYTAFGRGERHLSVVHGADAALPIAVAEVPAKPRTTRLQTLLRAQVPTAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JFT1</accession>
    <name>A0A2M9JFT1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Cupin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CG723_43410</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000043">
        <property type="protein sequence ID" value="PJN05663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN05663">
        <property type="protein sequence ID" value="PJN05663"/>
        <property type="gene ID" value="CG723_43410"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PJN05663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="108" mass="11484" checksum="39678F63254161F2" modified="2018-04-25" version="1">MTTTYDLNALADKHVAAARTSPHGRSAHLLLREETLRQSVIALTAGEVLEEHNAPPAATLQVLRGEVVLTAASGDVTLHEGRLHALPQERHGLRAVTDAAVLLTAVND</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JGH6</accession>
    <name>A0A2M9JGH6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Glycosyl hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CG723_41830</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000037">
        <property type="protein sequence ID" value="PJN05990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN05990">
        <property type="protein sequence ID" value="PJN05990"/>
        <property type="gene ID" value="CG723_41830"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PJN05990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="362" mass="39200" checksum="1E96397856EE0C2F" modified="2018-04-25" version="1">MTEVLLTVGTRKGLFIGRRRGGGAWEFDEGPYFNSQAVYSVAIDTRGDVPRLLAGGDSAHFGPSVFHSDDLGRTWTEPSHPAVKFPKDTGASLERVWQLHPAAAERDVVYAGTEPAALYRSEDRGETFDLVRPLWEHPTRSKWVPGGGGEGLHTVITDPRDASAVTVAVSTAGVFRTRDGGQSWQPANSGVSAVFLPDPNPEFGQCVHKVTQDAADPDRLYLQNHWGVYRSDDGGSRWNDIGAGLPSTFGFAAAAHPHRGDTAYVFPINADSDRVPAERHCRVFRTEDAGRSWEPLTAGLPQGDHYGTVLRDAMCTDDSDPAGVYFGNRNGEVYASADDGDSWRQLASHLPDVLCVRAAVVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JGI1</accession>
    <name>A0A2M9JGI1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Dipeptide ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CG723_41825</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000037">
        <property type="protein sequence ID" value="PJN05989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN05989">
        <property type="protein sequence ID" value="PJN05989"/>
        <property type="gene ID" value="CG723_41825"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015833">
        <property type="term" value="P:peptide transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013563">
        <property type="entry name" value="Oligopep_ABC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08352">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01727">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="6">
        <location>
            <begin position="6"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="6">
        <location>
            <begin position="354"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="614"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="42"/>
            <end position="49"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="397"/>
            <end position="404"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PJN05989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="683" mass="72728" checksum="4A7E54FBFFE484C1" modified="2018-04-25" version="1">MTEPLLRIDDLRVDIATRDRTVHALDGISLDLAAGEALGVVGESGCGKTMTALSVLGLLPPGGRITAGRVLFDGADLAAAPAPVLQDVRGNTVGMVFQDPLTSLNPTMTIGRQVAEPLLLHRGVSRKEAWARAEETLRLVGMPQPAERMKAYPHQLSGGMRQRVAIAMALVCEPKLLIADEPTTALDVTTQHQILELIDDLRERLGMAMILVTHDLGVIANRVDRVAVMYAGKVAEQGDVRDLFARPRHRYTEALFAALPERAGDGGTELHTIPGLPPNLTVRPEGCRFAPRCLFATDECRAQEPPLADDELRGAEHRFACFHPVPDVSGDGETAGVIAPAAIPAQSAPGATLLELDGLVKEFPLKGGPFSRSRGTVSAVGGVSLTIRKGETFGMVGESGCGKTTLGRIVAGLEDPTAGSVRFGGKDLAGLTRAGRRAHRRRIQLMFQDSTAAMDPRMRVGEILREPLVIQGVGSRAEQEAQIDGLLDAVGLPRGAVHRYPHEFSGGQRQRLGLARALTLSPDLVVADEPVSALDVSVQAQILNLMRELQRERGLTYLFISHDLAVVRYLADTVGVMYLGKLVETGPAEEVYARPLHPYTRGLLDTVNVPDPSAAAGSGAPLTGETPSAAKPPSGCRFRTRCPLARDVCAEVEPPVAAPRGAGHQVACHFPLPVPEEAAAQPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JGY7</accession>
    <name>A0A2M9JGY7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_41070</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000035">
        <property type="protein sequence ID" value="PJN06135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN06135">
        <property type="protein sequence ID" value="PJN06135"/>
        <property type="gene ID" value="CG723_41070"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="555"/>
            <end position="586"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN06135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="586" mass="64889" checksum="329C22AA3AE168FD" modified="2018-04-25" version="1">MLVSWTTLEATQTENVVAVMLCREHPRAVRIRPSQGDGGIDVVEVTEDGWVVYQIKYFANNLEAGQKSQIADSYRKVQAYAASRGARIAAWHLVLPLDATKENRFDWFRTLTQDAGYPCEWMGLTHLNGLAAKYQDVIDYFIGNGKEQLVTLLRQLHDFMGLQRSADRALNEGEPVPLAAVDVTNSLESLYRALNAHDPFYRYSFSVDQDRTMPQNEPTLVFASQTQDGDGPCITFRVYARYDQAVHDHELGIKWVVSFSEDKPAPQAFHEALTYGTPMTVTSAETASFNCILDLPGGLGGQFSNGTIRLGPAWQEEAPDRKLRLQLLNEAGQILESLTFEMEPTRRGLSGKGLSAFGRDASGILEVQTLTSLEGKRPTTMRFSRNPLEGLPPDEVLPALRFMARLKTPHSIRAAAPYGPVRSEPMPFQGDPNSDMHVMAARAAAVAEALSVVQEHTTEQLVMPDLLQTTFVEAARLQWIARLLRHETFTYQWDRAEMALPKETSPVPVTQGDVPEQRTFYLPLTITLAGQDRELGLGMERIDFPSALVEAAEGEDGWRLSCRPGDSTEGTSTHVPGAGPDGARPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JH03</accession>
    <name>A0A2M9JH03_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_41260</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000036">
        <property type="protein sequence ID" value="PJN06037.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN06037">
        <property type="protein sequence ID" value="PJN06037"/>
        <property type="gene ID" value="CG723_41260"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN06037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="122" mass="13452" checksum="34FE0F719C43F576" modified="2018-04-25" version="1">MLSADVLGDEAQWQGGARREQRPELAFRSAIPLPQFGQPDPLTVATPAQLVEALRAVRIWAGSPSLCTLEMRGRGRLSKSSVGAMLKSEELELPKYERFVAYLYACGIRDMASFTFSSSVCR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JHF4</accession>
    <name>A0A2M9JHF4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_40670</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000034">
        <property type="protein sequence ID" value="PJN06187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN06187">
        <property type="protein sequence ID" value="PJN06187"/>
        <property type="gene ID" value="CG723_40670"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001646">
        <property type="entry name" value="5peptide_repeat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00805">
        <property type="entry name" value="Pentapeptide"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="34"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="69"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="182"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="388"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="394"/>
            <end position="419"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN06187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="419" mass="45852" checksum="96233F3AE6EAEF69" modified="2018-04-25" version="1">MRLPPVGDHAAMTMETPGRSDQQRDRWYKHHPRWAWTAGIVGTAAFVVLLIWGPWWIEGHHLRDDKGQLVSSAGIIVTGFRTMLIAIVAGAVAAAGLWYTHKSHQQTEKLFEHTRAKDREQAELTREGQVTDRYVDAIKLLASDKLHERLGGIYSLERIMQDSEKDRGTVTEVLAAFVRDKLPPSGADGEGTQRGLDPEVRGLKEDHTSPLDADVRSAINVLGRNWEGGRARADLRTINGASLNMAELDLRGAQLQRAYLAMANLSDANLSRAQLSRANLDATKLSHTNLAAAHLKWARLSHARMHHVDLTGANLRGALLSGARMRQVALEGVDLADAYLKGAVLDEVSGLTADVLCRARIYQSTKLPTHLAQDPKVQARIAHCEALQRSLEAVGPPPPVPDGNSTPGQPADPPSRPRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-05-25" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JHG1</accession>
    <name>A0A2M9JHG1_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">OmpR/PhoB-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CG723_39940</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CB01635</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AfsR/DnrI/RedD regulatory family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000032">
        <property type="protein sequence ID" value="PJN06316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN06316">
        <property type="protein sequence ID" value="PJN06316"/>
        <property type="gene ID" value="CG723_39940"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd15831">
        <property type="entry name" value="BTAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005158">
        <property type="entry name" value="BTAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03704">
        <property type="entry name" value="BTAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01043">
        <property type="entry name" value="BTAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0902">Two-component regulatory system</keyword>
    <feature type="domain" description="OmpR/PhoB-type" evidence="4">
        <location>
            <begin position="1"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="3">
        <location>
            <begin position="1"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PJN06316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="273" mass="30070" checksum="0458EB48ECA38C2D" modified="2018-04-25" version="1">MKIQVLGPLSAAVNGMSIVPTAGKPRQILALLALYPGRVVPVPTLMEEIWGTELPQSALTTLQTYILQLRRRLGTAMGPGVPSAAKDVLATRHGGYLLQIPSEAVDVREYERLVAEGQQASDEGEDEQAARAYREALDLWEGAALVDVRVGPILSIEVMRLEESRLVTRERRIDADLRLGRHVEVIAELTDLIARHPQHEGLHSQAMVALYRSGRQAAALGIYHRLRGRLIEELGVEPAPQLQRLHHAMLAVDPKLDVICGPRRSSTFDLYAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-06-02" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JI28</accession>
    <name>A0A2M9JI28_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">L-serine dehydratase</fullName>
            <ecNumber evidence="9">4.3.1.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CG723_38845</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">CB01635</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>L-serine = NH4(+) + pyruvate</text>
            <dbReference type="Rhea" id="RHEA:19169"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="EC" id="4.3.1.17"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 9">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the iron-sulfur dependent L-serine dehydratase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.3.1.17" evidence="9"/>
    <dbReference type="EMBL" id="NNBL01000029">
        <property type="protein sequence ID" value="PJN06503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN06503">
        <property type="protein sequence ID" value="PJN06503"/>
        <property type="gene ID" value="CG723_38845"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003941">
        <property type="term" value="F:L-serine ammonia-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029009">
        <property type="entry name" value="ASB_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004644">
        <property type="entry name" value="Fe-S_L-Ser_mono"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005130">
        <property type="entry name" value="Ser_deHydtase-like_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005131">
        <property type="entry name" value="Ser_deHydtase_bsu"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03313">
        <property type="entry name" value="SDH_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03315">
        <property type="entry name" value="SDH_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143548">
        <property type="entry name" value="SSF143548"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00720">
        <property type="entry name" value="sda_mono"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="9" id="KW-0312">Gluconeogenesis</keyword>
    <keyword evidence="6 9" id="KW-0408">Iron</keyword>
    <keyword evidence="7 9" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="8 9 12" id="KW-0456">Lyase</keyword>
    <keyword evidence="5 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SDH_beta" evidence="11">
        <location>
            <begin position="4"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="domain" description="SDH_alpha" evidence="10">
        <location>
            <begin position="189"/>
            <end position="450"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU366059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF03313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF03315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PJN06503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="456" mass="48409" checksum="772F32E26B6A1101" modified="2018-04-25" version="1">MAISVFDLFSIGIGPSSSHTVGPMRAARMFARRLKNEGLLAHTAAIRAELYGSLGATGHGHGTPKAVLLGLEGDSPRTVDVEKADDRVEAIKASGKLSLLGVHEIPFSFDDDLVLHRRKALPYHANGMTIFAYDHEGALLLEKTYYSVGGGFVVDEDAVAGENPIVPDDTVLKYPFRTGDELLRLAEETGLSISALMLENEKAWRTEDEIRSGLLDIWRVMQACVSRGMSREGILPGGLKVRRRAANSARQLRAEGDPMARAMEWITLYAMAVNEENAAGGRVVTAPTNGAAGIIPAVLHYYINFVPGADEEGVVRFMLSAGAIGMLFKENASISGAEVGCQGEVGSACSMAAGALAEVLGGTPEQVENAAEIGMEHNLGLTCDPVGGLVQIPCIERNGMAAVKAVTAARMAMRGDGSHKVSLDKVIKTMKETGADMSVKYKETARGGLAVNIIEC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JI58</accession>
    <name>A0A2M9JI58_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CG723_38370</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000028">
        <property type="protein sequence ID" value="PJN06569.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN06569">
        <property type="protein sequence ID" value="PJN06569"/>
        <property type="gene ID" value="CG723_38370"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PJN06569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="183" mass="19297" checksum="FC5F8AA15938D215" modified="2018-04-25" version="1">MKKVVGGVVLGAVAVGAGLWGVLGPSGAREARAASPAAFKLWAAEAHAAVAREGGTATFNQRNGNGVSGAHQLGLRKGGHATIRIRDLDQSPEKATMLEGRTYSLTFACAGSGKFTVHAVGAKALRRDMYCTPTKKIETVSLNHLEGSRMGERRWDGRMDLTITTHGVQGVLSWHAAQMFTAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JI72</accession>
    <name>A0A2M9JI72_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Thioredox_DsbH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_38470</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000028">
        <property type="protein sequence ID" value="PJN06585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN06585">
        <property type="protein sequence ID" value="PJN06585"/>
        <property type="gene ID" value="CG723_38470"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02955">
        <property type="entry name" value="SSP411"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004879">
        <property type="entry name" value="DUF255"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024705">
        <property type="entry name" value="Ssp411"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42899">
        <property type="entry name" value="PTHR42899"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03190">
        <property type="entry name" value="Thioredox_DsbH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006402">
        <property type="entry name" value="UCP006402_thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="SSF48208"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredox_DsbH" evidence="1">
        <location>
            <begin position="3"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN06585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="672" mass="72502" checksum="86F9501A6C91CF9B" modified="2018-04-25" version="1">MPNRLAHETSPYLLQHADNPVDWWPWSADAFEEARRRGVPVLLSVGYSSCHWCHVMAHESFEDETTAALMNDRFVNIKVDREERPDVDAVYMEAVQAATGQGGWPMTVFLTPEAEPFYFGTYFPPEPRHGMASFPQILGGVAQAWAERKDEVAEVAAKIVGDLAGRELPYGDTQIPGEGELAQALLGLTREYDEANGGFGGAPKFPPSMVIEFLLRHYARTGAEGALQMAGDTCERMARGGIYDQLGGGFARYSVDREWVVPHFEKMLYDNALLCRAYAHLWRATGSETARRVALETADFMVRELRTNEGGFASALDADSEDAEGRHVEGAFYVWTPGQLREVLGDADAELAAEYFGVTQQGTFEEGASVLQLPQQETEFDAARVEDVRRRLFAARAERPAPGRDDKVVAAWNGLAIAALAETGAYFDRPDLVQAALAAADLLVRLHMDARARIARTSKDGRAGANAGVLEDYADVAEGFLTLASVTGEGVWLEFAGFLLDHVLDQFTDAESGALYDTAADAEQLIRRPQDPTDNATPSGWSAAAGALLSYAAQTGSEPHRTAAERALGVVRALGPRAPRFIGHGLAVAEALLDGPKEVAVVGEVGGELHRTALLGTAPGAVVAVGEVGSGELPLLADRPLVDGRPAAYVCRNFTCDAPVTDAQELAVKLQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JI86</accession>
    <name>A0A2M9JI86_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Flp pilus assembly protein CpaB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">cpaB</name>
        <name evidence="4" type="ORF">CG723_38335</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000028">
        <property type="protein sequence ID" value="PJN06563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN06563">
        <property type="protein sequence ID" value="PJN06563"/>
        <property type="gene ID" value="CG723_38335"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017592">
        <property type="entry name" value="Pilus_assmbl_Flp-typ_CpaB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031571">
        <property type="entry name" value="RcpC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013974">
        <property type="entry name" value="SAF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16976">
        <property type="entry name" value="RcpC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08666">
        <property type="entry name" value="SAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03177">
        <property type="entry name" value="pilus_cpaB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014637719" evidence="1">
        <location>
            <begin position="25"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="domain" description="SAF" evidence="2">
        <location>
            <begin position="47"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="domain" description="RcpC" evidence="3">
        <location>
            <begin position="107"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08666"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF16976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PJN06563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="236" mass="25410" checksum="D81A5C3B800616C1" modified="2018-04-25" version="1">MNSRQRRGVILLVISALCAVGAFAGVLSVIRDVNSKVGPEVAAYRLKDDVAPYKELTADRFEKVEMPERWLSKTAVTSLSQIRGKIAVTTLKKGSLLQTDMIVARPQLRDGQQEIAIMIDAETGVAGKITPGSKVNIYATFKAANEKAKDQSKVIVENAEVMDVGKLTPIDEQGGDNGRRRQGEAVPITFALDPADAQRVAYAESFATHVRLALVAAGSDAAVPPGDRSYTLDEDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-09-29" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JI96</accession>
    <name>A0A2M9JI96_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 5 7">Histidine ammonia-lyase</fullName>
            <shortName evidence="5">Histidase</shortName>
            <ecNumber evidence="3 5 7">4.3.1.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5 9" type="primary">hutH</name>
        <name evidence="9" type="ORF">CG723_38610</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CB01635</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 5 7">
            <text>L-histidine = NH4(+) + trans-urocanate</text>
            <dbReference type="Rhea" id="RHEA:21232"/>
            <dbReference type="ChEBI" id="CHEBI:17771"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:57595"/>
            <dbReference type="EC" id="4.3.1.3"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 5 7">Amino-acid degradation; L-histidine degradation into L-glutamate; N-formimidoyl-L-glutamate from L-histidine: step 1/3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5 8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="5">Contains an active site 4-methylidene-imidazol-5-one (MIO), which is formed autocatalytically by cyclization and dehydration of residues Cys-Ser-Gly.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5 6">Belongs to the PAL/histidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.3.1.3" evidence="3 5 7"/>
    <dbReference type="EMBL" id="NNBL01000028">
        <property type="protein sequence ID" value="PJN06609.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN06609">
        <property type="protein sequence ID" value="PJN06609"/>
        <property type="gene ID" value="CG723_38610"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00379">
        <property type="reaction ID" value="UER00549"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004397">
        <property type="term" value="F:histidine ammonia-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019556">
        <property type="term" value="P:histidine catabolic process to glutamate and formamide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019557">
        <property type="term" value="P:histidine catabolic process to glutamate and formate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00332">
        <property type="entry name" value="PAL-HAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.275.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00229">
        <property type="entry name" value="His_ammonia_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001106">
        <property type="entry name" value="Aromatic_Lyase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024083">
        <property type="entry name" value="Fumarase/histidase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005921">
        <property type="entry name" value="HutH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008948">
        <property type="entry name" value="L-Aspartase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022313">
        <property type="entry name" value="Phe/His_NH3-lyase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10362">
        <property type="entry name" value="PTHR10362"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00221">
        <property type="entry name" value="Lyase_aromatic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48557">
        <property type="entry name" value="SSF48557"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01225">
        <property type="entry name" value="hutH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00488">
        <property type="entry name" value="PAL_HISTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 5 7" id="KW-0369">Histidine metabolism</keyword>
    <keyword evidence="5 6 9" id="KW-0456">Lyase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="modified residue" description="2,3-didehydroalanine (Ser)" evidence="5">
        <location>
            <position position="144"/>
        </location>
    </feature>
    <feature type="cross-link" description="5-imidazolinone (Ala-Gly)" evidence="5">
        <location>
            <begin position="143"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PJN06609.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="512" mass="52939" checksum="A25057EBD3205170" modified="2018-04-25" version="1">MHTVVVGTSGVSAADVVAVARADARIELSEEAVAALASARAIVDALAAKPEPVYGVSTGFGALATRHISQDLRAQLQRNIVRSHAAGMGPRVEREVVRALMFLRLKTVCSGHTGVRPEVAQTMADVLNAGITPVVHEYGSLGCSGDLAPLSHCALTLMGEGDAEGPDGVLAPAGELLAAHGIAPVELREKEGLALLNGTDGMLGMLVMALADLESLYKSADITAALSLEALLGTEKVLAPELHAIRPHPGQGASAANMLAVLKGSELTGHHQDDAPRVQDAYSVRCAPQVAGAGRDTMAHARLVAERELASAVDNPVVLPDGRVESNGNFHGAPVAYVLDFLAIAAADLGSIAERRTDRLLDKNRSHGLPPFLADDAGVDSGLMIAQYTQAALVSEMKRLAVPASADSIPSSAMQEDHVSMGWSAARKLRTAIDNLTRIVAVELYAATRGIELREGLTPAPASRAVIDAVRAAGVQGPGPDRFLAPDLAAADAFVRGGHLVAAVEPVTGPLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JIL6</accession>
    <name>A0A2M9JIL6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Beta-glucosidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_38120</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000027">
        <property type="protein sequence ID" value="PJN06692.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN06692">
        <property type="protein sequence ID" value="PJN06692"/>
        <property type="gene ID" value="CG723_38120"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1700">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026891">
        <property type="entry name" value="Fn3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002772">
        <property type="entry name" value="Glyco_hydro_3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036881">
        <property type="entry name" value="Glyco_hydro_3_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001764">
        <property type="entry name" value="Glyco_hydro_3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036962">
        <property type="entry name" value="Glyco_hydro_3_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14310">
        <property type="entry name" value="Fn3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00933">
        <property type="entry name" value="Glyco_hydro_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01915">
        <property type="entry name" value="Glyco_hydro_3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00133">
        <property type="entry name" value="GLHYDRLASE3"/>
    </dbReference>
    <dbReference type="SMART" id="SM01217">
        <property type="entry name" value="Fn3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52279">
        <property type="entry name" value="SSF52279"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fn3_like" evidence="2">
        <location>
            <begin position="671"/>
            <end position="741"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN06692.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="753" mass="78814" checksum="757765CA4A30B26C" modified="2018-04-25" version="1">MNEPLYRDPAAPVRERVRDLLGRMTLTEKVGQLNQRMYGWHAYQRTGSGHRLTDAFRSEVAAYDGMGALYGLQRADPWSGVTFADGITAADAAGVADAVQRHMVEQTRLGIPVLLVEEVPHGHQALDGTVLPVNLAVGSTWDPDLYEEAAAGAGAELRARGGHLALVSALDLVRDPRWGRAEECFGEDPYLAARFTEALVRGMRRAGVGVVLKHFAGQGSSVGGRNSAATEIGVRELHEIHLAAARAGVRAGAAGVMAAYNEFDGLPCAASRYLLTELLRERWGFDGIVMADGGALDRLTRLAGDPAAAGALALAAGTDLSLWDDCFPRLGEAVERGLVAEATVDSAVERVLALKFRLGLFERPYVGRPEQPSGVRELSERLARESIVLLEHDGVTLPLGLSLRRIAVMGPGADSVPGQIGDYTAPQRPGSGVTVLDGIRAGAAPGAEVTYARGCELVGGDLSGVPEAVALAASAEVAVLVLGGSSAREGDTHFEANGAAVVSSGNPVGMTCGEGVDLADLRLPDGQSALLDAVAATGTPVVVVLVQGRPHALPDLTGKAKGVLCAWYPGPWGGRAVADVLFGAASPAGRLPVSVPRSAAQLPVFYNAKDHDYRGYVDQSATARHAFGHGLSYSTVEYAAPRLAHSTVTAGEPGTTCSVTVTNTGTRPVRETVQLYVRRVSGGTSWPRARELRGFVRLDLEPGGSAEAVFALDAEVLASVTRGLDLAVEPGEVQIETGPSSDRTRGTALTVTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JJ30</accession>
    <name>A0A2M9JJ30_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 5">N5-carboxyaminoimidazole ribonucleotide synthase</fullName>
            <shortName evidence="3 5">N5-CAIR synthase</shortName>
            <ecNumber evidence="3 5">6.3.4.18</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3 5">5-(carboxyamino)imidazole ribonucleotide synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3 5" type="primary">purK</name>
        <name evidence="7" type="ORF">CG723_37000</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CB01635</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR).</text>
    </comment>
    <comment type="function">
        <text evidence="5">Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)- to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3 5">
            <text>5-amino-1-(5-phospho-beta-D-ribosyl)imidazole + ATP + hydrogencarbonate = 5-carboxyamino-1-(5-phospho-D-ribosyl)imidazole + ADP + 2 H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:19317"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58730"/>
            <dbReference type="ChEBI" id="CHEBI:137981"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.4.18"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 5">Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate from 5-amino-1-(5-phospho-D-ribosyl)imidazole (N5-CAIR route): step 1/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 5">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 5">Belongs to the PurK/PurT family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.18" evidence="3 5"/>
    <dbReference type="EMBL" id="NNBL01000025">
        <property type="protein sequence ID" value="PJN06878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN06878">
        <property type="protein sequence ID" value="PJN06878"/>
        <property type="gene ID" value="CG723_37000"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00942"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034028">
        <property type="term" value="F:5-(carboxyamino)imidazole ribonucleotide synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004638">
        <property type="term" value="F:phosphoribosylaminoimidazole carboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01928">
        <property type="entry name" value="PurK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003135">
        <property type="entry name" value="ATP-grasp_carboxylate-amine"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005875">
        <property type="entry name" value="PurK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040686">
        <property type="entry name" value="PurK_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011054">
        <property type="entry name" value="Rudment_hybrid_motif"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02222">
        <property type="entry name" value="ATP-grasp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17769">
        <property type="entry name" value="PurK_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51246">
        <property type="entry name" value="SSF51246"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="SSF52440"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01161">
        <property type="entry name" value="purK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 5" id="KW-0436">Ligase</keyword>
    <keyword evidence="3 4 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="1 3 5" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-grasp" evidence="6">
        <location>
            <begin position="120"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="116"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="165"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="198"/>
            <end position="201"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="206"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="284"/>
            <end position="285"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU361200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PJN06878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="400" mass="43021" checksum="DE6922BD6318C4B4" modified="2018-04-25" version="1">MILAPRGGRYPGGVTFPVVGMVGGGQLARMTHEAGIPLGIKFKLLSDTPQDSAAQVVSDVVIGDYRDLDTLRDFARGCDVITFDHEHVPTEHLRALEVDGIPVRPGPEALVHAQDKGVMRAKLTQIGAPCPRHRLVKDPADVAAFAAEGATDGDPASDGFPVILKTVRGGYDGKGVWFVRSLDDAAEPFKAGVPVLAEEKVDFVRELAANVVRSPHGQAVAYPVVESQQVDGVCDTVIAPAPGLDENLALLAEQLALGIAKELGVVGHLAVELFETRDGRILVNELAMRPHNSGHWTQDGAVTSQFANHVRAVLDLPLGDPRPRAPWTVMCNVLGGDYPDMYSAYLHCMARDPKLKIHMYGKDVKPGRKVGHVNTYGDDLDDVLERARHAAGYLRGTITE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JJ39</accession>
    <name>A0A2M9JJ39_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Acyl-CoA dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CG723_37030</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CB01635</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000025">
        <property type="protein sequence ID" value="PJN06883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN06883">
        <property type="protein sequence ID" value="PJN06883"/>
        <property type="gene ID" value="CG723_37030"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003995">
        <property type="term" value="F:acyl-CoA dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006089">
        <property type="entry name" value="Acyl-CoA_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="SSF47203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="SSF56645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00072">
        <property type="entry name" value="ACYL_COA_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00073">
        <property type="entry name" value="ACYL_COA_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0274">FAD</keyword>
    <keyword evidence="3 5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA_dh_N" evidence="8">
        <location>
            <begin position="14"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_M" evidence="7">
        <location>
            <begin position="128"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_1" evidence="6">
        <location>
            <begin position="235"/>
            <end position="384"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PJN06883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="385" mass="41450" checksum="6BE845C92DACC3DC" modified="2018-04-25" version="1">MAGSPEFDLYRPAEEHDMLRESVRALCEAKIAPFAAAVDEEARFPQEALDALVANDLQAVHVPEAYGGAGADALATVIVIEEVARVCASSSLIPAVNKLGSLPVILSGSEELKKKYMTPLAKGAGMFSYCLSEPDAGSDAAGMKTRAVRDGDSWVLNGVKRWITNAGESEYYTVMAVTDPTKRSKGISAFVVEKSDEGVSFGAPEKKLGIKGSPTREVYLDNVRIPADRMIGEEGTGFATAMKTLDHTRVTIAAQALGIAQGALDYAKGYVRERKQFGKPIADFQGIQFMLADMAMKIEAARALTYQAAAKSERGDADLTFQGAAAKCFASDVAMEVTTDAVQLLGGYGYTRDYPVERMMRDAKITQIYEGTNQVQRIVMARNLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JJY0</accession>
    <name>A0A2M9JJY0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">F420-dependent oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_34880</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000022">
        <property type="protein sequence ID" value="PJN07181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN07181">
        <property type="protein sequence ID" value="PJN07181"/>
        <property type="gene ID" value="CG723_34880"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019923">
        <property type="entry name" value="Lucif-like_OxRdtase_MSMEG_2516"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011251">
        <property type="entry name" value="Luciferase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036661">
        <property type="entry name" value="Luciferase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00296">
        <property type="entry name" value="Bac_luciferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51679">
        <property type="entry name" value="SSF51679"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03621">
        <property type="entry name" value="F420_MSMEG_2516"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bac_luciferase" evidence="2">
        <location>
            <begin position="12"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="133"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN07181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="296" mass="32555" checksum="FBC684A99B9E1681" modified="2018-04-25" version="1">MSRAFRFGVNMVTPATGDEWRKRCRRAEELGYDVILVADHLGVPSPFPSLVAAAEATERPRVGTFVLNAGFWNPVLLAREVATTDALTGGRLELGLGAGYVQAEHEAAGLPWGSPGERVDRLRRVVEELDRLLGSDEHQPRPAQRPRPPLLIGGNGDRLLKLTAEHAEIAAFTGARSVPGDPSGKLQHLAPGELDERVAAYHRFAAGRAEPAELNLLIQMVTVTDDRRAAIRPVLEHIPQFTQDEALELPLLLVGTVREIADQVRAQRDRYGFTYLTVLEPYMEAFGPVIEELRKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JK55</accession>
    <name>A0A2M9JK55_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Glycine dehydrogenase (decarboxylating)</fullName>
            <ecNumber evidence="7">1.4.4.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Glycine cleavage system P-protein</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Glycine decarboxylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Glycine dehydrogenase (aminomethyl-transferring)</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7 10" type="primary">gcvP</name>
        <name evidence="10" type="ORF">CG723_35315</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CB01635</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 7">The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 7">
            <text>(R)-N(6)-lipoyl-L-lysyl-[glycine-cleavage complex H protein] + glycine + H(+) = (R)-N(6)-(S(8)-aminomethyldihydrolipoyl)-L-lysyl-[glycine-cleavage complex H protein] + CO2</text>
            <dbReference type="Rhea" id="RHEA:24304"/>
            <dbReference type="Rhea" id="RHEA-COMP:10494"/>
            <dbReference type="Rhea" id="RHEA-COMP:10495"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:83099"/>
            <dbReference type="ChEBI" id="CHEBI:83143"/>
            <dbReference type="EC" id="1.4.4.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 7 8">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="4 7">The glycine cleavage system is composed of four proteins: P, T, L and H.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the GcvP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.4.4.2" evidence="7"/>
    <dbReference type="EMBL" id="NNBL01000022">
        <property type="protein sequence ID" value="PJN07259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN07259">
        <property type="protein sequence ID" value="PJN07259"/>
        <property type="gene ID" value="CG723_35315"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004375">
        <property type="term" value="F:glycine dehydrogenase (decarboxylating) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044249">
        <property type="term" value="P:cellular biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019464">
        <property type="term" value="P:glycine decarboxylation via glycine cleavage system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00613">
        <property type="entry name" value="GDC-P"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00711">
        <property type="entry name" value="GcvP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003437">
        <property type="entry name" value="GcvP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020581">
        <property type="entry name" value="GDC_P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11773">
        <property type="entry name" value="PTHR11773"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02347">
        <property type="entry name" value="GDC-P"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00461">
        <property type="entry name" value="gcvP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7 8" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="626"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="7 8">
        <location>
            <position position="709"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003788"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00033655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00711"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR603437-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PJN07259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="961" mass="101917" checksum="D95DA0077DC8BCAD" modified="2018-04-25" version="1">MTANRIPLSQLEQGIPFEQRHIGPDEAAQAKMLAQVGYGSLDELTAAAVPDVIKSAEALDLPGARTEAEVLAELRSLADRNQVLDSMVGLGYYGTFTPPVILRNVMENPAWYTAYTPYQPEISQGRLEALLNFQTMVAELTGLPTSGASLLDEGTAAAEAMALSRRIGKVKNGAFVVDADALPQTIAVIQTRAEPTGVEVVVADLSEGIPAEVAERGVVGVLIQYPGASGAVRDIKPVIEQAHELGAVVTVAADLLALTLLTSPGELGADIAVGTTQRFGVPMGFGGPHAGYMAVREKFARSLPGRLVGVSVDADGNKAYRLALQTREQHIRREKATSNICTAQVLLAVMAGMYAVYHGPDGLKGIARRTHRYATLLAEGLKAGGVEVVHGAYFDTLTVKAAGRAAGIVSAAREGGVNLHLVDADHVSISCDETTTRTQLGAVWTAFGVEADVDALDAAAEDTLPAGLLRGDSYLTHPVFHAHRSETSMLRYLRKLADRDYALDRGMIPLGSCTMKLNATTEMEPVTWPEFGQLHPFAPAEQAQGYLTLIRELEERLAEVTGYDKVSLQPNAGSQGELAGLLAVRGYHRANGDDQRTICLIPSSAHGTNAASAVMAGMKVVVVKTADDGEIDIADLRAKIEQYADELAVLMITYPSTHGVFEEHVADICAQVHDAGGQVYVDGANLNALVGLAKPGHFGGDVSHLNLHKTFCIPHGGGGPGVGPVGVRAHLAPYLPNHPMQPAAGPATGVGPISAAPWGSAGILPISWAYVRLMGGEGLKRATQVAVLSANYIAKRLEPHFPVLYTGPGGLVAHECIIDLRPISKATGVSVDDIAKRLIDYGFHAPTMSFPVAGTLMIEPTESEDLAELDRFCEAMIAIRGEIEKVGSGRWPAEDNPLRNAPHTAAALGGEWEHAYSREVAVFPAGVVAADKYWPPVRRIDQAYGDRNLVCSCPPMDAYED</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JK96</accession>
    <name>A0A2M9JK96_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">AAA family ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CG723_34065</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CB01635</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AAA ATPase family. RarA/MGS1/WRNIP1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000021">
        <property type="protein sequence ID" value="PJN07283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN07283">
        <property type="protein sequence ID" value="PJN07283"/>
        <property type="gene ID" value="CG723_34065"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032423">
        <property type="entry name" value="AAA_assoc_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008921">
        <property type="entry name" value="DNA_pol3_clamp-load_cplx_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021886">
        <property type="entry name" value="MgsA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16193">
        <property type="entry name" value="AAA_assoc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12002">
        <property type="entry name" value="MgsA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48019">
        <property type="entry name" value="SSF48019"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA" evidence="3">
        <location>
            <begin position="61"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008959"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PJN07283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="456" mass="48382" checksum="F04D6045716FC3D8" modified="2018-04-25" version="1">MEPDLFTAAAEDRQEKDPSSSPLAVRMRPRTLDEVVGQQHLLKPGSPLRRLVGEGGGGPAGPSSVILWGPPGIGKTTLAYVVSKATNKRFVELSAITAGVKEVRAVIDGARRALGGHGKETVLFLDEIHRFSKAQQDSLLPAVENRWVTLIAATTENPYFSIISPLLSRSLLLTLESLTDDDLRALLRRALTEERGLGGAVTLPDEAEGHLLRIAGGDARRALTALEAGAGSALAKQEKEITLQTLEESVDRAAVKYDRDGDQHYDVASALIKSIRGSDVDAALHYLARMIEAGEDPRFIARRLMISASEDIGLADPTALPTAVAAAQAVAMIGFPEAALTLSHATIALALAPKSNSATTAIGAAMEDVRKGLAGPVPPHLRDGHYKGAAKLGHAQGYVYPHDVPGGIAAQQYAPDAVKGKRYYQPTRYGAEARYADVAERVRERLTGEQPGAAGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JKL7</accession>
    <name>A0A2M9JKL7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">SAM-dependent methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_33480</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000020">
        <property type="protein sequence ID" value="PJN07419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN07419">
        <property type="protein sequence ID" value="PJN07419"/>
        <property type="gene ID" value="CG723_33480"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041698">
        <property type="entry name" value="Methyltransf_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13649">
        <property type="entry name" value="Methyltransf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransf_25" evidence="1">
        <location>
            <begin position="60"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN07419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="241" mass="26005" checksum="E6C2CF707BFE164F" modified="2018-04-25" version="1">MFAPEGPTVRELAVQALSSVEHGYDLLAPKFDRTPFRTPLSVLAPVTRALRRMGPFERGLDLCCGTGAGFGVLRQVCRERPVGVDISAGMLTAGRAAHTSGADLVRADALALPFGPAFDLVVSFGAFGHFLPRQRPALFAQVHSVLRPGGRFAFPVPAPARPGSRGYWSMLAFDGAMRVRNALWRPPFVMYYRGFRLGDVRSELVAAGFGVELQALPELGERSDGSPRCRLLVATKTGAPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JKQ1</accession>
    <name>A0A2M9JKQ1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">GntR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_34470</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">In the C-terminal section; belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000021">
        <property type="protein sequence ID" value="PJN07357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN07357">
        <property type="protein sequence ID" value="PJN07357"/>
        <property type="gene ID" value="CG723_34470"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044249">
        <property type="term" value="P:cellular biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="CDD" id="cd07377">
        <property type="entry name" value="WHTH_GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
        <property type="entry name" value="GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00035">
        <property type="entry name" value="HTHGNTR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00345">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50949">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH gntR-type" evidence="2">
        <location>
            <begin position="32"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN07357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="499" mass="52998" checksum="3BC0F00BB6A8EAC4" modified="2018-04-25" version="1">MAQWTSAVGAAQLARLLTSQQTRPPGPGSRRPPAYRALSDGIRLLVLEGRVPVAARLPAERELAVSLAVSRTTVAAAYEALRGEGFLESRRGAGSWTAVPAGNPLPARGLEPLPPEALGSMIDLGTAALPAPEPWLTRAVQGALGELPPYAHTHGDYPAGLPALREMLAERYTARGIPTMPEQIMVTTGAMGAIDAICHLFAGRGERIAVESPSYANILQLMREEGARLVPVAMAEGLAGWDLDRWRQVLRDAAPRLAYVVADFHNPTGALADEDQRRQLVDAARSAGTVLVVDETMTELHFDHDLDMPRRVCAFDPAGSTVITVGSASKAFWAGMRIGWVRAAPDVIRSLVAARAYADLGTPVVEQLAVNWLLSTGGWEEAVQLRRSQARDNSTALVAALRRELPDWEFDVPVGGLTLWVRAGGLSGSRLAEVGERVGVRVPSGPRFGVDGAFEGYVRLPFTVSGAVADEAAARLAAAARLVREGGASGAEPPRTLIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JKT6</accession>
    <name>A0A2M9JKT6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Acyl-CoA synthetase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_33890</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000020">
        <property type="protein sequence ID" value="PJN07484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN07484">
        <property type="protein sequence ID" value="PJN07484"/>
        <property type="gene ID" value="CG723_33890"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-binding" evidence="1">
        <location>
            <begin position="41"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding_C" evidence="2">
        <location>
            <begin position="474"/>
            <end position="548"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN07484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="565" mass="61400" checksum="F62CF3ACA36A415E" modified="2018-04-25" version="1">MKIEEYLEDLRARQARVRPHGTPSDVVYPLGEISVPDHVAHWARLRPDRAAVVFEGRTVTYRELDELSRRVAGRLASEGVGAGDRVAVHLPNCPQFLVAFLAVLRLGAVHVPVNPMFQGAELAYELADCGAETVITLDTSLPLLASVRQQTAVRRVFVTSLTEMAHSATAPDAVAIEGLAVHTWAQAVAHKPVDGAPADLDALAALNYTGGTSGLPKGCMHTQRHMIYTIATSAGATRQKADGEVVVLCYIPVFWIAGEDLGILNPLMLGGTSVLMPRWDPARVLRAIDGHKVTTMVGTVENYLELLDRTDFATYDLSSLVDPLCTSFIRKLDVGVRRRWEAAAGAHSVLREAAYGMTETHTIDVTPYGFQGGDEDLHAEPVFCGLPMPGTDIAVMSPLTGEPLPLGEAGEIVVRSPSVTTGYWNKPDATERQLRDGWLHTGDNGRINEDGCLHYLGRDKDLIKVKGMSVFPAEVEMLLCRHPDVHTAAVVPAADPTKGQIPVAFVTLRQKGAVEASVLRDWARESMAPYKVPLVEIVDEMPMTTTMKIRKVDLTARAQQLADGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JL09</accession>
    <name>A0A2M9JL09_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CG723_32855</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000019">
        <property type="protein sequence ID" value="PJN07561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN07561">
        <property type="protein sequence ID" value="PJN07561"/>
        <property type="gene ID" value="CG723_32855"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="4"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="35"/>
            <end position="42"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PJN07561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="303" mass="33324" checksum="9A227B96999D1CC6" modified="2018-04-25" version="1">MTTINIDHVSRWFGNVVAVNDITMTISPGVTGLLGPNGAGKSTLINMMGGFLAPSNGTVTLDGEPIWRNEQVYRHIGIVPEREAMYDFLTGREFVVANAELQGLGTHEAQKALATVEMEYAQDRKISTYSKGMRQRVKMASALVHEPSVLLLDEPFNGMDPRQRMQLMDLLRRMGAEGRTVLFSSHILEEVEQLASHIEVIVAGRHAAGGDFRKIRRLMTDRPHRYLIRSSDDRALAAALIADPSTAGIEVDLKEGALRVQAVDFGRFTTLLPQVAKAHGIRLLTVSPSDESLESVFSYLVAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JLD6</accession>
    <name>A0A2M9JLD6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF2269 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_33010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000019">
        <property type="protein sequence ID" value="PJN07587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN07587">
        <property type="protein sequence ID" value="PJN07587"/>
        <property type="gene ID" value="CG723_33010"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="58"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="88"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="130"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN07587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="177" mass="18976" checksum="10B50F3260831762" modified="2018-04-25" version="1">MKLRRPARRATLVVHVTSSACWLGLTLGLLALAVTAITAGSDPMVEAACRAMKVFTDWLVIPLALLTLLSGLLLSLGTPWGLARHRWVYAKFWLTLATTAASIFALRPGVNAAVATVMAGAPLPRPSDLVAGPIVSLTAYLFMTVISVLKPWGLTRRGRKQHAARKAVDADRPRQSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-05-25" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JLG4</accession>
    <name>A0A2M9JLG4_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 11">Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase</fullName>
            <shortName evidence="11">NN:DBI PRT</shortName>
            <ecNumber evidence="5 11">2.4.2.21</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10 11">N(1)-alpha-phosphoribosyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">cobT</name>
        <name evidence="14" type="ORF">CG723_32105</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">CB01635</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 11">Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6-dimethylbenzimidazole (DMB).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>5,6-dimethylbenzimidazole + nicotinate beta-D-ribonucleotide = alpha-ribazole 5'-phosphate + H(+) + nicotinate</text>
            <dbReference type="Rhea" id="RHEA:11196"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15890"/>
            <dbReference type="ChEBI" id="CHEBI:32544"/>
            <dbReference type="ChEBI" id="CHEBI:57502"/>
            <dbReference type="ChEBI" id="CHEBI:57918"/>
            <dbReference type="EC" id="2.4.2.21"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 11">Nucleoside biosynthesis; alpha-ribazole biosynthesis; alpha-ribazole from 5,6-dimethylbenzimidazole: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 11">Belongs to the CobT family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.21" evidence="5 11"/>
    <dbReference type="EMBL" id="NNBL01000018">
        <property type="protein sequence ID" value="PJN07716.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN07716">
        <property type="protein sequence ID" value="PJN07716"/>
        <property type="gene ID" value="CG723_32105"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00061">
        <property type="reaction ID" value="UER00516"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008939">
        <property type="term" value="F:nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009236">
        <property type="term" value="P:cobalamin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02145">
        <property type="entry name" value="BluB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02439">
        <property type="entry name" value="DMB-PRT_CobT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1610.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.109.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10210">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00230">
        <property type="entry name" value="CobT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012825">
        <property type="entry name" value="BluB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003200">
        <property type="entry name" value="Nict_dMeBzImd_PRibTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017846">
        <property type="entry name" value="Nict_dMeBzImd_PRibTrfase_bact"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023195">
        <property type="entry name" value="Nict_dMeBzImd_PRibTrfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036087">
        <property type="entry name" value="Nict_dMeBzImd_PRibTrfase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029479">
        <property type="entry name" value="Nitroreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000415">
        <property type="entry name" value="Nitroreductase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02277">
        <property type="entry name" value="DBI_PRT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00881">
        <property type="entry name" value="Nitroreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52733">
        <property type="entry name" value="SSF52733"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55469">
        <property type="entry name" value="SSF55469"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02476">
        <property type="entry name" value="BluB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03160">
        <property type="entry name" value="cobT_DBIPRT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0169">Cobalamin biosynthesis</keyword>
    <keyword evidence="8 11" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Nitroreductase" evidence="13">
        <location>
            <begin position="591"/>
            <end position="758"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="522"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="12">
        <location>
            <begin position="91"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="11">
        <location>
            <position position="1117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00015486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00030686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="PJN07716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="1149" mass="119359" checksum="37B46610A0BA71B4" modified="2018-04-25" version="1">MTDTGQVPGEGLPENAGTVEQPGVPAPGAYTFLDPSETPTEEDDLLLMPGSQGAWGEPQAAPMPAPHEPGPHETAGRDSGHVDLNGVRVPGPSPAPHPGPARRPLHMGPPVPDGTGSPVRSLADRGPAHTPPNPMPVRQAGPPTTEPEYLDIPRDETGAPAPQLGEIPPLGAAAWGAQPPQQGFEAPAAVAETAAEAAPDVAAETVVPDATPVAPAAPTQQTVGDAPVFAQAPQHPQDVHAAQAEPAELTPEALAAPEFAAPEEVPVYAAAPDGGLFAEEQAAPAEYAVDYSSAPNGVQFAPVAQGPEGAQFAVQPEPVAAYAGHQRVAAHPGELPLDPHSGQFAMAPEAVQGQHFPQAPAEGQADQAPQPLGQFVPVEGNIPTTPHLAPTPPQHMVVPPLPEPAAELPEPAAPAAPAPVLIDETPETPAADQVPQAQEAHEVHVVPETHEAHAMNDAAHAMNEAHAMNEPQLTHETAAIPEATELSGTAEAPEAPAEPSPVLAETPVPAEADAAEREIAPEAAEPVTAEAEQALAVSEPETLVPAPRESEPAIQDMADAAPETLAPADDLAGPAAPGYDEAEREAVLRVMRERRDIRNGFRSDPIPHDVLLRVLEAAHTAPSVGHSQPWDFVVIRSAETRRTMHELAMRQKDAYAKSLPKGRAKQFKELKIEAILDTPVNIVVTADPTRGGRHTLGRHTQPQMAPYSSALAVENLWLAARAEGLGVGWVSFFDEREMVRTLGLPDHLEVVAYLCVGYVDEFPDEPELMQAGWSKRRPLSWVVHEETYGRRALPGEDPHDLLAETVSNIRPLDAKALGEAWERQKRMTKPAGALGMLEIISAQLSGLSRMCPPPIPEPAAVAIFAGDHGVHAQGVTPWPQEVTAQMVANFLGGGAVCNAFANQVGAEVCVIDVGVASELPATPGLLPRKVRAGTADMTTGPALSREDVKAAIEVGIETARDLVAAGNKGLLTGEMGIANTTASAALISVYTGVDPSEVTGRGTGINDETHARKVEVVRRALDLHQPDPADPIGVLAAVGGLEHAAMVGLLLGGASLRTPVILDGVSAGAAALVARAIAPEVLAACIAGHRSAEPGHVAALNKLGLRPLVDLDLRLGEGTGALLALPIVQSAARAMHEVATFDSAGVTEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-09-29" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JLK4</accession>
    <name>A0A2M9JLK4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Bile acid:sodium symporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CG723_32220</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CB01635</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000018">
        <property type="protein sequence ID" value="PJN07738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN07738">
        <property type="protein sequence ID" value="PJN07738"/>
        <property type="gene ID" value="CG723_32220"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002657">
        <property type="entry name" value="BilAc:Na_symport/Acr3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004710">
        <property type="entry name" value="Bilac:Na_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038770">
        <property type="entry name" value="Na+/solute_symporter_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10361">
        <property type="entry name" value="PTHR10361"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01758">
        <property type="entry name" value="SBF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="24"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="57"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="85"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="115"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="142"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="183"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="208"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="238"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="273"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PJN07738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="330" mass="33938" checksum="F6EA83B52CDD2A24" modified="2018-04-25" version="1">MHRPVQTEQLTPQQTRPTDTGNRAARLAVTVFPVLVLAAGGIGLALPDAFVSWKTNVPYLLGVVMFCMGLTMTPHDFKGVAKRPWAVGLGLVAHYVIMPGLGWLIANALDLPPQLAAGVILVGCAPSGTASNVVTYLARGDVALSVSVATVSTVLAPLVTPPLTLLLAGEFLPVDAGSMVTDILKTVLLPVVAGLVVRLVLGRYVDRVLGFLPWLSALTIAVIVAVVVAGSATAIKSAAGLVLLAVVLHNGLGLALGYGAGKLARLGAPASRAMAFEVGMQNSGLAASLATAHFSPLAALPAAVFSVWHNVSGALVAAWMSYRARRAEQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JLX3</accession>
    <name>A0A2M9JLX3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Group II intron reverse transcriptase/maturase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">ltrA</name>
        <name evidence="2" type="ORF">CG723_31150</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000017">
        <property type="protein sequence ID" value="PJN07859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN07859">
        <property type="protein sequence ID" value="PJN07859"/>
        <property type="gene ID" value="CG723_31150"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030931">
        <property type="entry name" value="Group_II_RT_mat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013597">
        <property type="entry name" value="Mat_intron_G2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08388">
        <property type="entry name" value="GIIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="SSF56672"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04416">
        <property type="entry name" value="group_II_RT_mat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="1">
        <location>
            <begin position="89"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN07859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="484" mass="54733" checksum="D3FD5A9F9DE7CF47" modified="2018-04-25" version="1">MPEDAPPNGGALGPRARVLEMQTKLHRWTVADTGRRFDDLFNFVHDPATLLVAFDRVAGNQGARTPGVDGLTATDVEESIGVPGFLNDLRAALKDGTFRPLPVRERMIPKPGGSGKVRKLGIPTIADRVVQAALKLVLEPIFEADFKPVSYGFRPRRRAQDAIAEIHYFGTRGYRWVLDADIEACFDSIDHTALMDRVRRRVKDKRVLTLVKAFLKAGVLTELGENKETLTGTPQGGILSPLLANIALSALDEHLHGPWEPSGAMATEGKRAYRRRKGQPTWRVVRYADDFVVLVHGTEADTAALREEVAGVLEPLGLRLSQAKTRITHMSDGFDFLGFRIQWKRKGGTTKWHVYTFIADRPIRSLKAKVRALTGRTSQQDLVTVLKRITQIMRGWANYFKHAVAKHVFDRLDAFVWWRLIRMLRERHRWSWGDVRRRFTTANGRWRPIAADGIELFRIASVTVSRYRYRASTIPNPWQPANPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JM40</accession>
    <name>A0A2M9JM40_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CG723_31005</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000017">
        <property type="protein sequence ID" value="PJN07837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN07837">
        <property type="protein sequence ID" value="PJN07837"/>
        <property type="gene ID" value="CG723_31005"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PJN07837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="87" mass="9343" checksum="3C05A3D197993CE9" modified="2018-04-25" version="1">MAGSVVPHWRVGLTLEVLAPDYQRLVGVLEAEAGGSGLRARELAGRLGLESVPAKVEGVRSKVKRLVERGWLAEERPGVFTPRRAAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JMD2</accession>
    <name>A0A2M9JMD2_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">TPP_enzyme_N domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_30490</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000016">
        <property type="protein sequence ID" value="PJN08022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08022">
        <property type="protein sequence ID" value="PJN08022"/>
        <property type="gene ID" value="CG723_30490"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030976">
        <property type="term" value="F:thiamine pyrophosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012001">
        <property type="entry name" value="Thiamin_PyroP_enz_TPP-bd_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02776">
        <property type="entry name" value="TPP_enzyme_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TPP_enzyme_N" evidence="2">
        <location>
            <begin position="33"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN08022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="90" mass="9875" checksum="D6CFAFC6D39FF6E5" modified="2018-04-25" version="1">MRPKREDLRQRRTGRSARAPTRSRIGRGPLAVTVSDVFSGILRHHGVKAVFGNPGSNELSFLTGRPDGIPYYVVLQEGAAIDIADGFAQW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-09-29" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JMG7</accession>
    <name>A0A2M9JMG7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Sarcosine oxidase subunit beta</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_30740</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000016">
        <property type="protein sequence ID" value="PJN08060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08060">
        <property type="protein sequence ID" value="PJN08060"/>
        <property type="gene ID" value="CG723_30740"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008115">
        <property type="term" value="F:sarcosine oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046653">
        <property type="term" value="P:tetrahydrofolate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006278">
        <property type="entry name" value="SoxB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01373">
        <property type="entry name" value="soxB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rhodanese" evidence="1">
        <location>
            <begin position="28"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN08060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="409" mass="44102" checksum="0774339733BCC45D" modified="2018-04-25" version="1">MTAQPQPTLPEHPDFLWRNPEPRSSYDVVIVGAGGHGLATAYYLAKEHGITNVAVLEKGWLAGGNMARNTTIIRSNYLWDESAAIYEHALKLWEGLPEELDYDFLFSQRGVLNLAHTLQDVREGMRRANANRLNGVDAEWLDPDQVAEVCPILNVSPDTRYPVLGGTFQPRAGIAKHDHVAWALARRADEMGVDLIQGCEVTGFVKDGEKVVGVETNLGRINAGRVGLAAAGHSSVLAERAGIRLPVQSHPLQALVSELHEPVHPTVVMSNHVHVYVSQAHKGELVMGAGVDSYNGYGQRGSFHVIEEQMAAAVELFPIFARAHVLRTWGGIVDVTPDASPIISATPVENLFVNCGWGTGGFKATPAAGWTFAHTIATGEAHPLNAPFALDRFTTGALIDEHGAAAVAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JN55</accession>
    <name>A0A2M9JN55_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Anion-transporting ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_28210</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000014">
        <property type="protein sequence ID" value="PJN08289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08289">
        <property type="protein sequence ID" value="PJN08289"/>
        <property type="gene ID" value="CG723_28210"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025723">
        <property type="entry name" value="Anion-transp_ATPase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016300">
        <property type="entry name" value="ATPase_ArsA/GET3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10803">
        <property type="entry name" value="PTHR10803"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02374">
        <property type="entry name" value="ArsA_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ArsA_ATPase" evidence="2">
        <location>
            <begin position="26"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="325"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="375"/>
            <end position="398"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN08289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="470" mass="49408" checksum="7CFA24F8A1069384" modified="2018-04-25" version="1">MTSSLSLNPTDTHVLDVDPLIDDPGTRIVVCCGSGGVGKTTTAAALGLRAAERGRKVVVLTIDPARRLAQSMGIDSLDNTPRRVKGIATVEGAEGGELHAMMLDMKRTFDEIVEAHADGQRAEAILGNPFYQSLSAGFAGTQEYMAMEKLGQLRARDEWDLIVVDTPPSRSALDFLDAPKRLGSFLDGKLIRVLMAPAKVGGRAGMKFLNVGMSMMTGALGKLLGGQLLRDVQTFVAAMDTMFGGFRTRADATYKLLQAPGTAFLVVAAPERDALREAAYFVERLAAEDMPLAGLVLNRVHGSGAAQLSAERALAAAENLDERGIVDQGDGKVELRTAPEAGSPAPARDTADEHAQTPDKTPHSAPVHAHASNSPGAGTPATATTDRATADRAATDHSATDQLTAGLLRLHAERMQLLAREQRTRDRFAALHPEVAVTEVGALPGDVHDLAGLRTIGDRLAAGADPAGAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JN76</accession>
    <name>A0A2M9JN76_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Chaplin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CG723_28430</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000014">
        <property type="protein sequence ID" value="PJN08322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08322">
        <property type="protein sequence ID" value="PJN08322"/>
        <property type="gene ID" value="CG723_28430"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007155">
        <property type="term" value="P:cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005528">
        <property type="entry name" value="ChpA-H"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03777">
        <property type="entry name" value="ChpA-C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51884">
        <property type="entry name" value="CHAPLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0034">Amyloid</keyword>
    <keyword evidence="2" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015006586" evidence="5">
        <location>
            <begin position="28"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="domain" description="Chaplin" evidence="6">
        <location>
            <begin position="40"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PJN08322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="81" mass="7371" checksum="0E839DC558BA09CA" modified="2018-04-25" version="1">MNTAKKAALVMTVAGLAAGAASGSAFAHGGAGAEGAAVGSPGVGSGNVVQVPIDVPVNVVGNTVNGIAGLNPAFGNSGQNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JN86</accession>
    <name>A0A2M9JN86_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_28510</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000014">
        <property type="protein sequence ID" value="PJN08333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08333">
        <property type="protein sequence ID" value="PJN08333"/>
        <property type="gene ID" value="CG723_28510"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041617">
        <property type="entry name" value="TPR_MalT"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17874">
        <property type="entry name" value="TPR_MalT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="2">
        <location>
            <begin position="40"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="464"/>
            <end position="484"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN08333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="484" mass="51559" checksum="2C89B1A92483D2EA" modified="2018-04-25" version="1">MTHDSTPEAGGPGSIPEGEPGLVPDAEPAEPADEPIGRRVLRLRTERGLTQRQVAEPVYTPAYISTLEAGRVRPSDAALRHVAERLGVTYEELTTGQPAHLATRLRLRLTEAQRGLITGAAEEAAVLYEKLRAEAERHGLTAEQAAAELGLGECALETGELPDAHRHFEAAEALLVAVGAPLPQRAPVVRARALAHYLSGELRYACYLLESALDELNTSGLHDPDALLLLYTATIAPYMDMGAHARAAQAAELALSLAPQAGDPVLVAKMHRSVARTLLAEGRAAEADASLSKAAELYQRLQIRTELAHCHWMRGYVHAQDGRLADAERELRTARDMLSAKRAVLYTTQVEVELADVLRRRGSSDEAAALLRALLGDLNPERGAVHAAGAHRLLGIIAEESGASGDPEDTAAAEAAEEHYVTALSLLERAGAAGDLADLCRLLGDLYRRTGRIDAALDTYRTGLGHRAAPGTTTLGPAPAEPPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-09-29" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JNF6</accession>
    <name>A0A2M9JNF6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CG723_28870</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CB01635</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000014">
        <property type="protein sequence ID" value="PJN08398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08398">
        <property type="protein sequence ID" value="PJN08398"/>
        <property type="gene ID" value="CG723_28870"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="52"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="83"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="108"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="142"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="170"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="204"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="242"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="289"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="322"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="351"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="382"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="423"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="506"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="17"/>
            <end position="529"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PJN08398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="538" mass="55383" checksum="CB0E77A3E6EFCA2D" modified="2018-04-25" version="1">MAPAAGTAESSTTARLVLLTLAAGQFLMALDSSVMNVSIATVAEDVGTTVTGIQGAITAYTLVMAMFMIPGGKVGALIGRKRAFMIGCIIYGCGSLTTALAPNLPVLLLGWALLEGVGAALIMPAIVALVAGNFVTERRPAAYGLVAAAGAVAIAVGPLIGGVATTYFSWRWVFAGEVVVVLGILVLARRIADAPVGERSRIDLLGCVLSALGLGIFVYGVLRSDEWGWFQPKPGAPSWLGISLVVWLALAGLLLIWLFLRWEARLVKRRKEPLIDPALLQNKQLTGGLTMFFFQYLVQMGVFFVVPLYLSVALGLSALKTGARILPLSLTLLAAAILIPRFLPDVSPRRVVRLGILALLAGAVALMAALDAGAGAEIVTLPLLLIGLGMGALASQLGSVTVSAVPEAQSAEVGGVQNAVTNLGASLGTALAGSILIAALTTSFVTGIEQNPAVPADVKSQTSVELQSGAPFLSDAQLKTALGEAGTSAEVSQAALDANNEARLDGLRAALAVLALASLLAMFFTSRIPTTQPRSATP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JNX4</accession>
    <name>A0A2M9JNX4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CG723_27770</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000013">
        <property type="protein sequence ID" value="PJN08571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08571">
        <property type="protein sequence ID" value="PJN08571"/>
        <property type="gene ID" value="CG723_27770"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025361">
        <property type="entry name" value="DUF4265"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14085">
        <property type="entry name" value="DUF4265"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PJN08571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="165" mass="17134" checksum="039C81DFDA995ED0" modified="2018-04-25" version="1">MSIESPAPSDHCHVALRAGFASSGKPVFETLPARAVSPGSYELTGSPGMVEGCAAGDLLKIDADGLFQIERRGPNLCIQAFGDPPFDAESLESLTSAFIPLGGLVEAPADRRFIVVTVPAAAGFPAVEAVMGTWTAGVSALVEWGFSNVFGPDGEPLNWWQGSEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JNZ1</accession>
    <name>A0A2M9JNZ1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CG723_27930</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000013">
        <property type="protein sequence ID" value="PJN08592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08592">
        <property type="protein sequence ID" value="PJN08592"/>
        <property type="gene ID" value="CG723_27930"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PJN08592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="252" mass="27542" checksum="C8B8D67A15C38F5F" modified="2018-04-25" version="1">MGAKTGLLVYADGDVPGLLRQVGAADLEQTSVMMRRLNPSCEIEESHGSDLYEGVYPPDGTAYAASWPGVEIVCDRRVMIDSPSQLPGHLVAASAGRRLVLHAMHSVVDWLAFAVWEDGRLIRSLSLSPDDGIIENIGEPLPFELPYWAGDRPADVIPWPGEEEEPYALPFHPLELGEDALRALCGFIQEGMPESGDVDAENIELHGFRVRDPNGSDPAEKEAELRRVVETMGPPQFYRMGPDGLLVESNSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-05-25" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JP17</accession>
    <name>A0A2M9JP17_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">LacI family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CG723_27865</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000013">
        <property type="protein sequence ID" value="PJN08585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08585">
        <property type="protein sequence ID" value="PJN08585"/>
        <property type="gene ID" value="CG723_27865"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01392">
        <property type="entry name" value="HTH_LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000843">
        <property type="entry name" value="HTH_LacI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046335">
        <property type="entry name" value="LacI/GalR-like_sensor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00356">
        <property type="entry name" value="LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13377">
        <property type="entry name" value="Peripla_BP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00036">
        <property type="entry name" value="HTHLACI"/>
    </dbReference>
    <dbReference type="SMART" id="SM00354">
        <property type="entry name" value="HTH_LACI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50932">
        <property type="entry name" value="HTH_LACI_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH lacI-type" evidence="4">
        <location>
            <begin position="11"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PJN08585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="351" mass="37083" checksum="22AFA1C359A0AC7B" modified="2018-04-25" version="1">MATSAPGPRPPTIADVARVAGVSRTTVSHALNGLGKVDPRTRERVRQVAAELGYRPNLRAQRLRRGQAKAIALASSMPFAVAGGPSRLGFYMEVAAAAAESALLHDYALVLVPPVQSDSALYSVDIDGAIVVEPEVDDAAVAQLRERGLPYVTLGRPVSAEEDALYVDLRGELVVELLLAHLHEQGAVRPALIVGSGSRRSSVDALTAYERVAARHGWTPIVARVPESGGEQAGYERCAELLAEHPDVDAVCALVDAFAVGAVRAIRDSGRTVPDGVMVVTRYDGLRARTCEPPLTAVDLHLDKAASDAVELLLGRLRGDAATPSVAVSPNPRVIVRASSARVGRRSTTRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JPL9</accession>
    <name>A0A2M9JPL9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">FmdB family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_27015</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000012">
        <property type="protein sequence ID" value="PJN08737.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08737">
        <property type="protein sequence ID" value="PJN08737"/>
        <property type="gene ID" value="CG723_27015"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013429">
        <property type="entry name" value="Regulatory_FmdB_Zinc_ribbon"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09723">
        <property type="entry name" value="Zn-ribbon_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00834">
        <property type="entry name" value="CxxC_CXXC_SSSS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02605">
        <property type="entry name" value="CxxC_CxxC_SSSS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CxxC_CXXC_SSSS" evidence="2">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="50"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="54"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN08737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="109" mass="10953" checksum="F7ABBAD5F1EBE4CA" modified="2018-04-25" version="1">MPTYQYQCTECGEGLEAVQKFTDDALTVCPSCDGRLKKVFSAVGIVFKGSGFYRNDSRGSSSSSSPAPAKSTTSDTKPSSSDSKSSSASTSSASASSSSSGSSSSSSAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-06-02" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JQ13</accession>
    <name>A0A2M9JQ13_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Zf-CGNR multi-domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_26040</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000011">
        <property type="protein sequence ID" value="PJN08946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08946">
        <property type="protein sequence ID" value="PJN08946"/>
        <property type="gene ID" value="CG723_26040"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3300.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010852">
        <property type="entry name" value="ABATE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023286">
        <property type="entry name" value="ABATE_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021005">
        <property type="entry name" value="Znf_CGNR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35525">
        <property type="entry name" value="PTHR35525"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07336">
        <property type="entry name" value="ABATE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11706">
        <property type="entry name" value="zf-CGNR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160904">
        <property type="entry name" value="SSF160904"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="zf-CGNR" evidence="2">
        <location>
            <begin position="141"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="182"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="194"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF11706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN08946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="209" mass="22885" checksum="21BC84B052098C8D" modified="2018-04-25" version="1">MELAYYSDYAVRLVNSEEPGRGKDSLTTVEAVRDLFGANQSAARRATDADLTRFRGVRARLRSVFEAADGGDETLAVDLLNSLLLEFPVSPQISGHDHRDDDDRPLWHMHLADHPSNATAGYAAIAAMGLAFHLTEYGVDRLGLCEASPCRNAYLDTSTNRSRRYCSDRCATRANVAAYRARKRAEADRSDSTGRSAENAQAATAATDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JQ38</accession>
    <name>A0A2M9JQ38_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RNA polymerase sigma factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CG723_26280</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CB01635</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000011">
        <property type="protein sequence ID" value="PJN08991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08991">
        <property type="protein sequence ID" value="PJN08991"/>
        <property type="gene ID" value="CG723_26280"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006950">
        <property type="term" value="P:response to stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039425">
        <property type="entry name" value="RNA_pol_sigma-70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014293">
        <property type="entry name" value="RNA_pol_sigma70_actinobac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000838">
        <property type="entry name" value="RNA_pol_sigma70_ECF_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013249">
        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43133">
        <property type="entry name" value="PTHR43133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08281">
        <property type="entry name" value="Sigma70_r4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02947">
        <property type="entry name" value="SigH_actino"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01063">
        <property type="entry name" value="SIGMA70_ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0731">Sigma factor</keyword>
    <keyword evidence="4 5" id="KW-0804">Transcription</keyword>
    <keyword evidence="2 5" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="7">
        <location>
            <begin position="99"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4_2" evidence="8">
        <location>
            <begin position="205"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="25"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF08281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PJN08991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="283" mass="30920" checksum="4BD65D3A98C35379" modified="2018-04-25" version="1">MGSTICPSRSSAADLEWSVLHAAKTAPIRTAGGPDRQAASAEGRLFSDSSGVSFGPATSLEEVGPVTGTDAGTEHGQAEEPEETAAERSLRFERDALTFLDQMYSAALRMTRNPADAEDLVQETYAKAYASFHQFREGTNLKAWLYRILTNTFINSYRKKQREPQRSAAEEIEDWQLARAESHMSTGLRSAESQALDHLPDSDVKSALQAIPEEFRIAVYLADVEGFAYKEIADIMGTPIGTVMSRLHRGRRQLRGMLEDYARDRGLVPAGAGESNEAKGSGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-05-25" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JQR3</accession>
    <name>A0A2M9JQR3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Aldo/keto reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_25225</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000010">
        <property type="protein sequence ID" value="PJN09213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN09213">
        <property type="protein sequence ID" value="PJN09213"/>
        <property type="gene ID" value="CG723_25225"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NADP_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="SSF51430"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldo_ket_red" evidence="1">
        <location>
            <begin position="15"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN09213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="331" mass="35892" checksum="C0F845CEEDE9993B" modified="2018-04-25" version="1">MKYTQLGRTGLKVSRLVLGTMNFGPQTDEADSHAIMDTALASGINYFDTANVYGWGENKGRTEEIIGSWFAQGGDRRDKTVLATKVYGNMAGAGTDSPWPNHDKLSAVNIRRAVEASLKRLGTDYIDIYQFHHVDRETPFEEIWQAVDVLIQQGKILYAGSSNFPGYKIAQANEKAAARGTLGLVSEQCLYNLSERRAEMEVIPAAQEYGLGVIPWSPLHGGLLGGVIRKEVEGGRRASGRAADALANPETRAQLQAYEDLLDKHGLAPGEAALAWLLTRPGVTGPIVGPRTSEQLDSALRAVELELSEEVLTGLDEIFPGPGPSPEAFAW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JRT8</accession>
    <name>A0A2M9JRT8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Tat pathway signal sequence domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_22800</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000008">
        <property type="protein sequence ID" value="PJN09568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN09568">
        <property type="protein sequence ID" value="PJN09568"/>
        <property type="gene ID" value="CG723_22800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006059">
        <property type="entry name" value="SBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13416">
        <property type="entry name" value="SBP_bac_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014793050" evidence="1">
        <location>
            <begin position="36"/>
            <end position="558"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN09568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="558" mass="60010" checksum="6D85710D71CAF954" modified="2018-04-25" version="1">MTPNSPSASAPSRRSFLASTAVAAAAVAGGMPLLAACGGSENKDREGTTSGKAADKLLPTFVASKFARPDVPSKNGSASGYTGKVALSALVASAPDKLGTGAPIKVMSPLWGTAPKGDCAYYKAVDKAAGTKVTWQNQDGTTYGEKLGAVLASSSIPDMVVVPSWELTGKIPNAVAAKFMDLGPYLAGDKVKKYPNLAAIPSDSWRMSIFGGNLRGIPMPSARATFIVPYYRKDLFDKKGYDVPTSPDEFTSWAKDATSAKAKVYACGDMSWTAFNIFGVRASGSLGWHIGDDGKLTYRIEQPEYLEALEWTRKLFDAGVVHPDDKARTGDAGQRFTAGQILVYNNDISNWYVKSAEQAKANPDFVCEAIDIFGADGGDPTLYANQPATIWSFIRKGASRTTVENALAAANFAAAPYGTKERMLVDYGVEGTHYTVKDGLPVKTDQGNQEAINAWVMLAAPAPYLAHPDLPDVTRKQVEWEQRMGAFTRKTSTYGMNIVEPSRYANLASPFEQLEIDYVRGNKKLSDLQQAISTWKSGGGEKLRDWYKKLIEKNGSGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JSD8</accession>
    <name>A0A2M9JSD8_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Proline--tRNA ligase</fullName>
            <ecNumber evidence="8">6.1.1.15</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Prolyl-tRNA synthetase</fullName>
            <shortName evidence="8">ProRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">proS</name>
        <name evidence="10" type="ORF">CG723_21615</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CB01635</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys-tRNA(Pro) is not edited by ProRS.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>ATP + L-proline + tRNA(Pro) = AMP + diphosphate + L-prolyl-tRNA(Pro)</text>
            <dbReference type="Rhea" id="RHEA:14305"/>
            <dbReference type="Rhea" id="RHEA-COMP:9700"/>
            <dbReference type="Rhea" id="RHEA-COMP:9702"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:60039"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78532"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.15"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="2 8">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="8">Consists of three domains: the N-terminal catalytic domain, the editing domain and the C-terminal anticodon-binding domain.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the class-II aminoacyl-tRNA synthetase family. ProS type 1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.15" evidence="8"/>
    <dbReference type="EMBL" id="NNBL01000007">
        <property type="protein sequence ID" value="PJN09795.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN09795">
        <property type="protein sequence ID" value="PJN09795"/>
        <property type="gene ID" value="CG723_21615"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002161">
        <property type="term" value="F:aminoacyl-tRNA editing activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004827">
        <property type="term" value="F:proline-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006433">
        <property type="term" value="P:prolyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00861">
        <property type="entry name" value="ProRS_anticodon_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00779">
        <property type="entry name" value="ProRS_core_prok"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.800">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01569">
        <property type="entry name" value="Pro_tRNA_synth_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002314">
        <property type="entry name" value="aa-tRNA-synt_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004154">
        <property type="entry name" value="Anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036621">
        <property type="entry name" value="Anticodon-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002316">
        <property type="entry name" value="Pro-tRNA-ligase_IIa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004500">
        <property type="entry name" value="Pro-tRNA-synth_IIa_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023717">
        <property type="entry name" value="Pro-tRNA-Synthase_IIa_type1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044140">
        <property type="entry name" value="ProRS_anticodon_short"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033730">
        <property type="entry name" value="ProRS_core_prok"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036754">
        <property type="entry name" value="YbaK/aa-tRNA-synt-asso_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007214">
        <property type="entry name" value="YbaK/aa-tRNA-synth-assoc-dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03129">
        <property type="entry name" value="HGTP_anticodon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00587">
        <property type="entry name" value="tRNA-synt_2b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04073">
        <property type="entry name" value="tRNA_edit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01046">
        <property type="entry name" value="TRNASYNTHPRO"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55826">
        <property type="entry name" value="SSF55826"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00409">
        <property type="entry name" value="proS_fam_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 8 10" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AA_TRNA_LIGASE_II" evidence="9">
        <location>
            <begin position="52"/>
            <end position="467"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PJN09795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="564" mass="60924" checksum="06E600DDB0A1BEE4" modified="2018-04-25" version="1">MAQVQRMSKLMVKTLRDDPADAETLNHKLLVRAGYVRRTAAGIWSWLPLGKKVLENVARVVREEMDDMGGQEVLLPALLPKEPYEATGRWEEYGPELFRLKDRKGAEYLLGPTHEEIFTQLVKDQCSSYKDLPVILYQIQAKYRDEARPRAGILRGREFLMKDSYSFDTTDEGLAESYALHREAYIKIFERLGLDHRIVSAVSGAMGGSASEEFLAPAPAGEDTFVDCPACDYAANTEAVTFAAPAPASAEHPAVEELDTPDTPTIETLAAHLGVQASATLKNLLVKVDGEIVAVGVPGNREVDLGKLGEHLSPAVVELVTAEDFEGRDDLVRGYVGPQGLAKVRYIADPRIAAGTAWITGANKPGKHAKNVVAGRDFEVDDYLDVVVVEAGDPCPKCGTGLRLDRAIEIGHIFQLGRKYADAFQLDVLGNQGKPVRVTMGSYGIGVSRAVAALAEQTADDKGLCWPKEIAPADVHVVAAGKALQTELALDVSQKLGAAGVRVLVDDRAGVSPGVKFTDAELIGVPQILVAGRRSAEGIVELKDRKTGEREEVTVEEAVARLTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JSH8</accession>
    <name>A0A2M9JSH8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_21775</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000007">
        <property type="protein sequence ID" value="PJN09825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN09825">
        <property type="protein sequence ID" value="PJN09825"/>
        <property type="gene ID" value="CG723_21775"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014696113" evidence="1">
        <location>
            <begin position="18"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN09825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="175" mass="18294" checksum="6CF817040CB51FC0" modified="2018-04-25" version="1">MRLLPLAAVTAVMVAAAAGCGDSAEREYAVPSSLCGIHIKAATLAPLLPPGKRVSVKPDTPVPDAITTCEVAVDKRVVLSVERERREPGAAARDIAVDQLSAHDPKSAAARTIAYTDSAAVSITRCTAQDVVEADISTVIRVFEPGRKDESALKNLITEYTAALERSSPCEAKAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JT19</accession>
    <name>A0A2M9JT19_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CG723_20075</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CB01635</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LytR/CpsA/Psr (LCP) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000006">
        <property type="protein sequence ID" value="PJN10019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN10019">
        <property type="protein sequence ID" value="PJN10019"/>
        <property type="gene ID" value="CG723_20075"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004474">
        <property type="entry name" value="LytR_CpsA_psr"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03816">
        <property type="entry name" value="LytR_cpsA_psr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00350">
        <property type="entry name" value="lytR_cpsA_psr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="29"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="domain" description="LytR_cpsA_psr" evidence="4">
        <location>
            <begin position="120"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="66"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF03816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PJN10019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="357" mass="37375" checksum="F8EFE5CEA37752DA" modified="2018-04-25" version="1">MTASNWFTVVIIPTYVRPVKRIQRRRGRLVKTAGVVAGCVLVLTGGGAAWAYWHLDHNIRGVDIDSALGDDRPPKRAPATPEPSATAPPVGALNILVLGSDSRSGRKNSALGGGHSEGARSDTAMVVHLAAGRSSATVVSIPRDTLVERPACPASSGGTTQAAYGAMFNSAYSVGGPVCAVKTVEKLTGVRMDHYLEIDFSGFASVVDALGGVDVTTTEDIDDDLSHLQLDAGYHHLDGKQALAFARTRHGVGDGSDLGRIKLQQQLVKALVEKVSESDLLTNPARLYKVADALTGSLTTDTGLDSLGELQALAGSLKGLSADEVKTVMMPVLPAPSDPNRVVANEPEAGKLWASLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JTF8</accession>
    <name>A0A2M9JTF8_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">30S ribosomal protein S10</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">rpsJ</name>
        <name evidence="6" type="ORF">CG723_20335</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CB01635</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Involved in the binding of tRNA to the ribosomes.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Part of the 30S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uS10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000006">
        <property type="protein sequence ID" value="PJN10067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003948644.1">
        <property type="nucleotide sequence ID" value="NZ_NNBL01000006.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A2M9JTF8"/>
    <dbReference type="EnsemblBacteria" id="PJN10067">
        <property type="protein sequence ID" value="PJN10067"/>
        <property type="gene ID" value="CG723_20335"/>
    </dbReference>
    <dbReference type="GeneID" id="58435590"/>
    <dbReference type="GeneID" id="63982123"/>
    <dbReference type="GeneID" id="67399231"/>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.600">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00508">
        <property type="entry name" value="Ribosomal_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001848">
        <property type="entry name" value="Ribosomal_S10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018268">
        <property type="entry name" value="Ribosomal_S10_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027486">
        <property type="entry name" value="Ribosomal_S10_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036838">
        <property type="entry name" value="Ribosomal_S10_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11700">
        <property type="entry name" value="PTHR11700"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00338">
        <property type="entry name" value="Ribosomal_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00971">
        <property type="entry name" value="RIBOSOMALS10"/>
    </dbReference>
    <dbReference type="SMART" id="SM01403">
        <property type="entry name" value="Ribosomal_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54999">
        <property type="entry name" value="SSF54999"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01049">
        <property type="entry name" value="rpsJ_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00361">
        <property type="entry name" value="RIBOSOMAL_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Ribosomal_S10" evidence="5">
        <location>
            <begin position="7"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM01403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PJN10067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="102" mass="11521" checksum="87AE8768EB157E09" modified="2018-04-25" version="1">MAGQKIRIRLKAYDHEVIDSSAKKIVETVTRTGASVAGPVPLPTEKNVYCVIKSPHKYKDSREHFEMRTHKRLIDILDPTPKTVDSLMRLDLPAGVDIEIKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JTM8</accession>
    <name>A0A2M9JTM8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_17460</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000005">
        <property type="protein sequence ID" value="PJN10188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN10188">
        <property type="protein sequence ID" value="PJN10188"/>
        <property type="gene ID" value="CG723_17460"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025597">
        <property type="entry name" value="DUF4345"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14248">
        <property type="entry name" value="DUF4345"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="51"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="127"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN10188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="146" mass="15492" checksum="3D139C001EE9493F" modified="2018-04-25" version="1">MTGSPASTRFAALAMAMGIACVAIGLYHLVLGIASVPGEGSTGATVDSRERFYNAIIFGYGLAWIWAAPQSPIPSTAVRWLSGVFLLRGVGRVLSLAVHGWPHWLQVPLSALELALPPLSPGRRAWSPDGCAHGPDARSARRRRHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JTS9</accession>
    <name>A0A2M9JTS9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">SAM-dependent methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_17940</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000005">
        <property type="protein sequence ID" value="PJN10273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN10273">
        <property type="protein sequence ID" value="PJN10273"/>
        <property type="gene ID" value="CG723_17940"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000179">
        <property type="term" value="F:rRNA (adenine-N6,N6-)-dimethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020596">
        <property type="entry name" value="rRNA_Ade_Mease_Trfase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01131">
        <property type="entry name" value="RRNA_A_DIMETH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransf_11" evidence="2">
        <location>
            <begin position="45"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN10273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="259" mass="27474" checksum="E134289178C73004" modified="2018-04-25" version="1">MEQNERLLHSSSFGAAAPAYAEHRPDYAQAAVRWALEPAPGLRVLDLGAGTGKLTAALVALGAEVIAVEPDPAMLTELGRALPAVRALPGSAEAVPLPDASVDAVVAGNAMHWFDMDVAGPEIARVLAPGGVLAGLWNVFDNQVDWVAQLERVSGSAAIGPRDTRSSWRAETAGAHLPRAGLVARFGSPEQTEFPHGQRRTADSLVATFATKAGVLVMPEREREATLDPIRAFLTSRQETAHGEFTLPMLTGVLRVRRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JU04</accession>
    <name>A0A2M9JU04_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Alpha/beta hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_18550</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000005">
        <property type="protein sequence ID" value="PJN10371.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN10371">
        <property type="protein sequence ID" value="PJN10371"/>
        <property type="gene ID" value="CG723_18550"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="2">
        <location>
            <begin position="29"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN10371.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="291" mass="31977" checksum="EB248CC80D420EA0" modified="2018-04-25" version="1">MREIELSAGTIEYEDTGGQADADTKGPTVVFLHGLMMDASLWDGPIAELSGEHRCVAPTLPLGAHRRAMRDDTDLSLPGVARLVVEFLDRLDLRDVTLVGNDTGGALVQLVISEGAAERVGRVVLVSCEAFDNLPPGLTGRTLALAGKLPPRMFGLFMQQMRLGAVRRLPVAFGWLTKRGGAATGRWMRPVITQPEIRRDAVRMLRSVFADTRILLRAAERLPAFDRPALVVWAGDDRVMPVDHGRRLAELLPHGRLVEIEDSYTLIPLDQPTELASAVRKFTRVPDPDPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JUV1</accession>
    <name>A0A2M9JUV1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_15145</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000004">
        <property type="protein sequence ID" value="PJN10557.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN10557">
        <property type="protein sequence ID" value="PJN10557"/>
        <property type="gene ID" value="CG723_15145"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="137"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN10557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="164" mass="18241" checksum="DD1DFA0DAF7FE953" modified="2018-04-25" version="1">MAWEEWEQLKTDAEARRSTQMQINHVAPEGPGTFGDLKVKNADLEKIGKEAHSLFEHLGREGKVAHSSSNSAASNLKQQGFDLAAGLQHVSNRWEKQLGSLLDACAQISNHLHRTQSIHDGDEDYIRRTMSSIDTLDQGFDERVGKAGKPNPAYYGKPSEKKDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JUY3</accession>
    <name>A0A2M9JUY3_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 11">Beta-glucosidase</fullName>
            <ecNumber evidence="3 11">3.2.1.21</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CG723_15940</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">CB01635</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>Hydrolysis of terminal, non-reducing beta-D-glucosyl residues with release of beta-D-glucose.</text>
            <dbReference type="EC" id="3.2.1.21"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the glycosyl hydrolase 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.21" evidence="3 11"/>
    <dbReference type="EMBL" id="NNBL01000004">
        <property type="protein sequence ID" value="PJN10691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN10691">
        <property type="protein sequence ID" value="PJN10691"/>
        <property type="gene ID" value="CG723_15940"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008422">
        <property type="term" value="F:beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102483">
        <property type="term" value="F:scopolin beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030245">
        <property type="term" value="P:cellulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001360">
        <property type="entry name" value="Glyco_hydro_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018120">
        <property type="entry name" value="Glyco_hydro_1_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017736">
        <property type="entry name" value="Glyco_hydro_1_beta-glucosidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033132">
        <property type="entry name" value="Glyco_hydro_1_N_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10353">
        <property type="entry name" value="PTHR10353"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00232">
        <property type="entry name" value="Glyco_hydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00131">
        <property type="entry name" value="GLHYDRLASE1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03356">
        <property type="entry name" value="BGL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00572">
        <property type="entry name" value="GLYCOSYL_HYDROL_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00653">
        <property type="entry name" value="GLYCOSYL_HYDROL_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="4" id="KW-0136">Cellulose degradation</keyword>
    <keyword evidence="6 11" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="324"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="9">
        <location>
            <begin position="443"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="469"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="12">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="8">
        <location>
            <position position="183"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="8 10">
        <location>
            <position position="389"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="37"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="138"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="182"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="315"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="436"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR617736-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR617736-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU361175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PJN10691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="488" mass="53729" checksum="574E902E45D1A9EB" modified="2018-04-25" version="1">MPEPITQTPTTDPTPASPATPTFPPNFLWGAATSAYQIEGAVREDGRTPSIWDTFSHTPGKTAGGETGDIAVDHYHRYRDDVALMKDLDLGTYRFSVSWPRVQPTGRGPAVQRGLDFYRRLTDELLAKGIKPALTLYHWDLPQELEDAGGWPARDTAYRFAEYAGMVGEALGDRVDFWITLNEPWCSAFLGYGSGVHAPGRTDPAATLRAAHHLNLAHGLATQALRQTLPSRAEVAVSLNSSTVRPLSPESPADNDARRRIDNLANGVFHGPMLHGEYPADLITDTARITDWSFVHTTDLAAIHQPLDALGLNYYTPSLVSAAPSAPATRADGHGASDHSPWPGADDIAFHQSPGERTEMGWTIDPTGLHDLIMRYTREAPGLPLYITENGAAYDDKPDPEGRIHDPERIAYLHGHLSAVHRAIKDGADVRGYYLWSLMDNFEWAYGYEKRFGAVHVDYATQKRTPKSSAHWYAQASRTNTLPPPPQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JV12</accession>
    <name>A0A2M9JV12_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CG723_16090</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000004">
        <property type="protein sequence ID" value="PJN10713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN10713">
        <property type="protein sequence ID" value="PJN10713"/>
        <property type="gene ID" value="CG723_16090"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2840">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025736">
        <property type="entry name" value="PucR_C-HTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042070">
        <property type="entry name" value="PucR_C-HTH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012914">
        <property type="entry name" value="PucR_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13556">
        <property type="entry name" value="HTH_30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07905">
        <property type="entry name" value="PucR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PucR" evidence="2">
        <location>
            <begin position="47"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="domain" description="HTH_30" evidence="3">
        <location>
            <begin position="445"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PJN10713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="505" mass="52551" checksum="F411DE7BE8C9F94A" modified="2018-04-25" version="1">MEKTSTMPDATRPTVGPSGPPAPAVPPTPPVPLTALLAREDLGLRQIAGPPVGPDTVIHWAHTSEMADPYPYLLGGELLLTAGVHATESAGTGPYYDDYVARIVAAGGAALGFGVAPVHDTVPRALVEACERHGLPLLEVPPHSTFSGVTRAVWQLMAQARHAELRRVSEAQQGLATAAARPYPVPAVLRQLAQRTGGWAVLTAPDGSEVGRAGPDPTAEVSAAMVQLMRIVRPGETRLFPAPTSAADTVGGAHLAAYALGGGQGYALGTAVGHRDPGDHTIAGVAVVLLSLLTGEHQTTAEAARSAALVRLLFGEEPAGVAALLGDGNWRVVHAAPDGPSPPPVSLGTPLVDTTDSLVRALLPADQEVIAQEGWVMGVSGTAPTEDLAAADAQASRALTRARATHAPLVHHHVDARGLASLLDPGEATAHARTLLAPISHTPALTETLRTWLSLHGSWDRTATALAVHRNTVRQRIAKCATLLDTDLDDPDVRMELWFALRHAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JVI2</accession>
    <name>A0A2M9JVI2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Long-chain fatty acid--CoA ligase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_17030</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000004">
        <property type="protein sequence ID" value="PJN10869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN10869">
        <property type="protein sequence ID" value="PJN10869"/>
        <property type="gene ID" value="CG723_17030"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-binding" evidence="1">
        <location>
            <begin position="20"/>
            <end position="493"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN10869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="629" mass="67669" checksum="6583FC780A3205B0" modified="2018-04-25" version="1">MSDTQTLIENRPPSVAALFLERVAATPDTEAYRYPVPSASGEGPEEWKSLSWAQASARVYAIAAGLIELGVRPEERVALASSTRVEWILADLGILCAGAATTTVYPQTNAEESGFILADSDSKVLIAEDAAQLAKARERRADLPDLAHVVVIDEAGVEPDAADPEGWVLTLADLEKRGAAHLEKNPDLIKEKVGAITADQLATLIYTSGTTGRPKGVRLPQDNWSYMAKAIASTGLVGPDDVQYLWLPLAHVFGKVLTSGQIEVGHVTAVDGRVDKIIANLPVVQPTYMAAVPRIFEKVYNGVAAKARAGGGAKYKIFQWAAEVAREYAKASQDNFRRTGSASVPFALGAKHKVADALVYSKLREAFGGRLRACVSGSAALAPEIGYFFAGAGVHILEGYGLTETSAASFVNPGEAYRTGTVGKPLPGTEVRIADDGEILLRGPGVMQGYHGLPEKTTEVLESDGWFHTGDIGELSPDGYLKITDRKKDLIKTSGGKYIAPAEVEGQFKAVCPYVSNILVHGADRNFCTALIALDEPSILEWAKDNGLEGKSYADVVAAPATVEMVEGYVKELNLGLQKWQTVKKFKLLPRDLDIEHGELTPSLKLKRPVVEREYGHLIDEMYAGSREK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-06-02" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JVK2</accession>
    <name>A0A2M9JVK2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_16985</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000004">
        <property type="protein sequence ID" value="PJN10862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN10862">
        <property type="protein sequence ID" value="PJN10862"/>
        <property type="gene ID" value="CG723_16985"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="182"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="186"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN10862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="248" mass="27113" checksum="F2D07214DD23AF0D" modified="2018-04-25" version="1">MGEAVIAIVALMFVLFLALGAYVTVKVVGAAKRGVDRTVAQARRSVEDTTLKARTFVQPGAAGELAQLRLKLRTSMRSTQDALHARVAEDASLKESLDLFGRLSVHAHELDDDLKRLETEPDKAHLAELLPDLRKRTEQITASADSLRRAARDRAHRIADDDLDSLSAQIDIEAGALRHWTTEPSPEPVQTPPPWPEAPAPERPAAHQTWPGTPQGGQAEAPDRPALSPTDSRPAYPWQKKARPESTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JVP5</accession>
    <name>A0A2M9JVP5_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">2-isopropylmalate synthase</fullName>
            <ecNumber evidence="3">2.3.3.13</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Alpha-IPM synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="3">Alpha-isopropylmalate synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3 5" type="primary">leuA</name>
        <name evidence="5" type="ORF">CG723_17195</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CB01635</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>3-methyl-2-oxobutanoate + acetyl-CoA + H2O = (2S)-2-isopropylmalate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:21524"/>
            <dbReference type="ChEBI" id="CHEBI:1178"/>
            <dbReference type="ChEBI" id="CHEBI:11851"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="EC" id="2.3.3.13"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid biosynthesis; L-leucine biosynthesis; L-leucine from 3-methyl-2-oxobutanoate: step 1/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.3.13" evidence="3"/>
    <dbReference type="EMBL" id="NNBL01000004">
        <property type="protein sequence ID" value="PJN10898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN10898">
        <property type="protein sequence ID" value="PJN10898"/>
        <property type="gene ID" value="CG723_17195"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00048">
        <property type="reaction ID" value="UER00070"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003852">
        <property type="term" value="F:2-isopropylmalate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009098">
        <property type="term" value="P:leucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07942">
        <property type="entry name" value="DRE_TIM_LeuA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00572">
        <property type="entry name" value="LeuA_type2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013709">
        <property type="entry name" value="2-isopropylmalate_synth_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002034">
        <property type="entry name" value="AIPM/Hcit_synth_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005668">
        <property type="entry name" value="IPM_Synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036230">
        <property type="entry name" value="LeuA_allosteric_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039371">
        <property type="entry name" value="LeuA_N_DRE-TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000891">
        <property type="entry name" value="PYR_CT"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00682">
        <property type="entry name" value="HMGL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08502">
        <property type="entry name" value="LeuA_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00917">
        <property type="entry name" value="LeuA_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110921">
        <property type="entry name" value="SSF110921"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00970">
        <property type="entry name" value="leuA_yeast"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00815">
        <property type="entry name" value="AIPM_HOMOCIT_SYNTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00816">
        <property type="entry name" value="AIPM_HOMOCIT_SYNTH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50991">
        <property type="entry name" value="PYR_CT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="2 3" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="3" id="KW-0432">Leucine biosynthesis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pyruvate carboxyltransferase" evidence="4">
        <location>
            <begin position="37"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PJN10898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="572" mass="63119" checksum="0CCF3FD25CBD84A4" modified="2018-04-25" version="1">MSNFQRPTSMPVHKYGQYEQVDIPDRTWPGKRVTVAPRWLSTDLRDGNQALIDPMSPARKREMFDLLVRMGYKEIEVGFPASGETDFAFVRSIIEEGAIPDDVTISVLTQAREELIERTVESLKGAKRATVHLYNATAPTFREIVFRGTKEQIKQIAIDGTQHVMDYAEKVLGPETTFGYQYSPEIFTDTELDFALEVCEAVMEVYKPGPGREIILNLPATVERSTPSTHADRFEWMHRNLSNREYVCLSVHPHNDRGTAVAAAELALMAGADRIEGCLFGQGERTGNVDLVTLGMNLFSQGVDPQIDFSDIDEIRRTAEYCNQMEVHPRHPYAGDLVYTSFSGSHQDAIKKGFEAMDARAAAAGKSVDDIEWAVPYLPIDPKDVGRSYEAVIRVNSQSGKGGIAYVLKNDHKLDLPRRMQIEFSKIIQAKTDAEGGEVTPKEIWSVFQDEYLPHAENPWGRIQVKAGQSTTDTDGVDTLTVSADVDGEATVLTGTGNGPISAFFDALQAVGIDARLLDYQEHTMSEGASAQAASYIECAIGDKVLWGIGIDANTTRASLKAVVSAVNRSAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-05-25" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JVR5</accession>
    <name>A0A2M9JVR5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DNA-binding response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CG723_08270</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN10991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN10991">
        <property type="protein sequence ID" value="PJN10991"/>
        <property type="gene ID" value="CG723_08270"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00383">
        <property type="entry name" value="trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="3">
        <location>
            <begin position="3"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="domain" description="OmpR/PhoB-type" evidence="4">
        <location>
            <begin position="127"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="2">
        <location>
            <begin position="127"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PJN10991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="227" mass="25182" checksum="AABB2398BEBADA11" modified="2018-04-25" version="1">MTRVLVVEDDPQLVRALVINLEARRYGVDPAPDGATALRLAAARQPDVVVLDLGLPDMDGTDVIKALRGWTRVPILVLSARSASDEKVAALDAGADDYITKPFSMDELLARLRAAVRRTEAAPLAPDIVLVTTDEFSIDLLAKKASRGGHDVRLTPTEWHLLEILVTNPGRLITQKYLLQEVWGASQSNKTNYLRVYMAQLRRKLETDPAHPRYLITEPGMGYRFDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-09-29" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JVZ7</accession>
    <name>A0A2M9JVZ7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CG723_08695</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN11050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN11050">
        <property type="protein sequence ID" value="PJN11050"/>
        <property type="gene ID" value="CG723_08695"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PJN11050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="126" mass="13650" checksum="DCBFCE32D4FFAC46" modified="2018-04-25" version="1">MANALQELVKSRLEQQGWSYGDVARRGGIPRSTVHHLATVAQVARMPQQATLEGLARGLELPLDSVRRAAAEACGIHLYFEDPADTTSDPEIATLIASVQRLSDADRRHVTALIESLLRSTPGGPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JW82</accession>
    <name>A0A2M9JW82_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">XRE family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_09335</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN11150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN11150">
        <property type="protein sequence ID" value="PJN11150"/>
        <property type="gene ID" value="CG723_09335"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013096">
        <property type="entry name" value="Cupin_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07883">
        <property type="entry name" value="Cupin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01381">
        <property type="entry name" value="HTH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="6"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN11150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="178" mass="19528" checksum="5AB79D369EA9D094" modified="2018-04-25" version="1">MIGNRIRELRQSRKMTVRDLASRAGVSTGLVSQVERGLTDPSLETLRRLSAALGLPLFDLFRQDEPEAVALVRRDRRIVVRSPQGGIEYTRVSAGSARLEVLEGALEPGGASSEERYSHPSEECVVVLSGSLVVEAGDDRQELRPGDSCTFDSRVPHRYVNEGSEPARFLVSVTPPSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JWG5</accession>
    <name>A0A2M9JWG5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Multi-component regulatory system-11</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CG723_08935</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN11087.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN11087">
        <property type="protein sequence ID" value="PJN11087"/>
        <property type="gene ID" value="CG723_08935"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007995">
        <property type="entry name" value="DUF742"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36221">
        <property type="entry name" value="PTHR36221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05331">
        <property type="entry name" value="DUF742"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PJN11087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="107" mass="11192" checksum="F2F59AA685E411E7" modified="2018-04-25" version="1">MTAGRARTDNGAEHVDLMAIVRSTTATPRGPIPPEQRSLLAQCAQKPRPVADLASDSGLPLGVVRVLLGDLTAQGLIRITPPESTAAGKEPVSAHLLREVINGLRAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JWY1</accession>
    <name>A0A2M9JWY1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Dihydrofolate reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_10825</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN11405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN11405">
        <property type="protein sequence ID" value="PJN11405"/>
        <property type="gene ID" value="CG723_10825"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008703">
        <property type="term" value="F:5-amino-6-(5-phosphoribosylamino)uracil reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009231">
        <property type="term" value="P:riboflavin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.430.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024072">
        <property type="entry name" value="DHFR-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002734">
        <property type="entry name" value="RibDG_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01872">
        <property type="entry name" value="RibD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53597">
        <property type="entry name" value="SSF53597"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RibD_C" evidence="1">
        <location>
            <begin position="3"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN11405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="192" mass="20778" checksum="28F918C09DF5B5AF" modified="2018-04-25" version="1">MSKVVMHNVVSVDGFIADSEDQVGPLFDWYANGGIEIGSNGTVSMSKVSADYVRPMWESIGTLVIGRHLFDMTNGWEGKPPAGEHVVVVSHRPRPEGWHPEASYYFVDDVAKAIAKAKELAGDRTVGVAAGETGGQALALGLVDEVAMDVVPVVFGSGKRYFGSVDAQHLLEDPHVVIQGERVLHLLYKVRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JX70</accession>
    <name>A0A2M9JX70_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Glutamate-1-semialdehyde 2,1-aminomutase</fullName>
            <ecNumber evidence="4">5.4.3.8</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CG723_11335</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CB01635</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.4.3.8" evidence="4"/>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN11489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN11489">
        <property type="protein sequence ID" value="PJN11489"/>
        <property type="gene ID" value="CG723_11335"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042286">
        <property type="term" value="F:glutamate-1-semialdehyde 2,1-aminomutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044249">
        <property type="term" value="P:cellular biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005814">
        <property type="entry name" value="Aminotrans_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00202">
        <property type="entry name" value="Aminotran_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0413">Isomerase</keyword>
    <keyword evidence="1 2" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="210"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PJN11489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="463" mass="49467" checksum="EF15DA0706B03B4A" modified="2018-04-25" version="1">MDAEELLLPRSQLANKRLHAMIPGGAHTYAKGDDQYPENLAPVISHGRGAHVWDIDDNRYIEYGSGLRSVSLGHAHPRVLEAVRRELDRGSNFVRPSIVEVEAAERFLATVPTADMVKFAKNGSDVTTAAVRLARAVTGRTRVAICGDHPFFSVDDWFIGTSPMSAGVPAATTELTVAFPYGDLAATEELLTRYQDEVACLILEPLGHTEPSPSSQLLPEPSAGKCPASSGDPTPGYLAGLRELADRHGCVLIFDEMITGLRWSEAGAQGLYGVVPDLSTFGKALGNGFAVSALAGRRDLMERGGLRHSSERVFLLSTTHGAETHSLAAATAVLTTYVEEGITAQLHALGERLATGVREAAASMGVGDHVVVRGRASNLVFATLDENGQPSQQYRTLFLRRLIEGGILAPSFVVSSALGDADIDRTVDVVAQACAVYRKALDAADPTPWLAGRPVKPVFRRLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JXM4</accession>
    <name>A0A2M9JXM4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Acyl-CoA dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CG723_12185</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CB01635</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN11634.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN11634">
        <property type="protein sequence ID" value="PJN11634"/>
        <property type="gene ID" value="CG723_12185"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016627">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="SSF47203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="SSF56645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0274">FAD</keyword>
    <keyword evidence="3 5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA_dh_N" evidence="8">
        <location>
            <begin position="5"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_M" evidence="7">
        <location>
            <begin position="133"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_1" evidence="6">
        <location>
            <begin position="245"/>
            <end position="395"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PJN11634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="407" mass="45495" checksum="7A00A80C4B09962B" modified="2018-04-25" version="1">MFELTDRAKEYQEKLLAFMDERIYPAESVYEAQMAESGDPHFHPPVLEELKADAKKRGLWNLFHPHPEWGPGLTNLEYAPLAEIMGRSAHLAPEATNCNAPDTGNMEVLTLFGTDEHKEKWLKPLLDGEIASAFAMTEPAVASSDATNIQLRMERDGDDYVLNGRKWWTSNALHKNCKVLIVMGKTEPEAATHRQQSMMVVPIDTPGVTVLRNLPVFGYKDREGHAEVVFENVRVPVTALLAGEGDGFMISQARLGPGRIHHCMRAVGMAERALDLMIDRAQARTTFGEPVANRANVQDWIAESRIEIDMVRLLTLKAAYLMDTVGNRHARTEIAAIKVAAPEVALKVVDRAIQVHGGGGVSDDFPLASMYAHLRTLRLADGPDEVHKRTIAMRELRRREPQWGRTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JY41</accession>
    <name>A0A2M9JY41_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">5-carboxymethyl-2-hydroxymuconate isomerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_13140</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN11790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN11790">
        <property type="protein sequence ID" value="PJN11790"/>
        <property type="gene ID" value="CG723_13140"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.850.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011234">
        <property type="entry name" value="Fumarylacetoacetase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036663">
        <property type="entry name" value="Fumarylacetoacetase_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01557">
        <property type="entry name" value="FAA_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56529">
        <property type="entry name" value="SSF56529"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAA_hydrolase" evidence="1">
        <location>
            <begin position="47"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN11790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="282" mass="30938" checksum="7AA0E829F2FFC04B" modified="2018-04-25" version="1">MPEYRRILLDGAAVQVLREDDELVAGDGRRVKVEDAQHLPPVVPSKVVAVHLNHRSRVDEFQIELTPTPTYFHKPTSALNSHKGAIVRPEGCKWLNYEGEVAIVIGRTARNISPADAGEYIAGYTIANDYGLHDFRDTDAGSMLRVKGSDTLCPLGPGLVTDWDFHDKYLRTYVNGEVVQDGSTAEMEWDMHYLVADIARTITLYPGDVLLSGTPANSRPVQPGDIVEVEVEGLGRLTNHIVTGPTAIRTDVGAQPTESEEVLSTALGGDWEFRGIRPPSRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JY91</accession>
    <name>A0A2M9JY91_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CG723_13340</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN11821.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN11821">
        <property type="protein sequence ID" value="PJN11821"/>
        <property type="gene ID" value="CG723_13340"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PJN11821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="259" mass="26752" checksum="3839EFA7BDBBF7BC" modified="2018-04-25" version="1">MTSQNYLSELFSLDGRTAVVTGGSSGIGKAIAGALARAGASVVIVARKEAELTATVDELTAEGCRAAWVSADLSTRDGVRAAAERVAGVFGEPDILVNSAGINLRPPMSELDDEVWDATMAVNLEAPHLLGRRFGPGMAERGFGRIIHITSQQAHRAFVQSGAYGVSKGALEALARSQAEAWSPHGVTCNTLVPGFVMTPLNARLSSDPEKVAALAARTMVGRNGLAEDFAGAAVFLAGPASAYVTGQAIFVDGGFSVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JYD1</accession>
    <name>A0A2M9JYD1_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Transcriptional regulatory protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CG723_13700</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CB01635</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN11879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN11879">
        <property type="protein sequence ID" value="PJN11879"/>
        <property type="gene ID" value="CG723_13700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024187">
        <property type="entry name" value="Sig_transdc_resp-reg_cit/mal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45526">
        <property type="entry name" value="PTHR45526"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006171">
        <property type="entry name" value="RR_citrat_malat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0010">Activator</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0902">Two-component regulatory system</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="15"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="3">
        <location>
            <position position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRNR" id="PIRNR006171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PJN11879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="236" mass="25790" checksum="525B2E7F2828C574" modified="2018-04-25" version="1">MTASHDTAAGQDSIDVLVVDDDFMVARVHRSFVERVVPFRVIGTAHTGQQAIDAVEELRPDLILLDLYLPDIFGLDLIPRLRSAGHDCDIMVISAAQEAETVRRAVRRGVVDYLLKPFDFEDLLPRLERYAARRRRLLSAVVRGQADVDRVLGGTALATPGGGLPKGMSVETAAVVERALREAGSSLSATECAALTGISRVSARRYLEYFHGTGSAAVSLRYGVAGRPERRYDWQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-05-25" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JZ17</accession>
    <name>A0A2M9JZ17_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NADPH:quinone reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_09120</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN12106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN12106">
        <property type="protein sequence ID" value="PJN12106"/>
        <property type="gene ID" value="CG723_09120"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="PKS_ER"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PKS_ER" evidence="1">
        <location>
            <begin position="11"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN12106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="352" mass="37778" checksum="D71DE7E75487A6D7" modified="2018-04-25" version="1">MRALVAGEVGEPNDVLRLESRPVPTPEAGQALIRVKATPIHASDLHVLRGRYGFSPEFPTVGGHMECVGRIEALGPDTEGLKIGERVVAVAVPAIPGPRVAGTWQEYLVADMHRLLPVPDRLSDSSACQLAVNPLTALLLVTRELDVQPGEWLLQTAAGSTVGRLVIQLARHLGIRTINVVRRRDAVEEIKAFGGDEVICTEDEDLLQRVTEIAGPAGVRKAIDCVAGEIGAQVSQALAPGGELVVYGALSTHRQTAPAALTIPLLARSVIYETKVVRGFWLNRWFGTASPTDALRALSEVRSLVADEVLSIPQGRPFPLERFAEAVSFAETPAHGAKPLLVFEDGRDKGHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JZ27</accession>
    <name>A0A2M9JZ27_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Xaa-Pro aminopeptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CG723_09665</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CB01635</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the peptidase M24B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN12121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN12121">
        <property type="protein sequence ID" value="PJN12121"/>
        <property type="gene ID" value="CG723_09665"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.350.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007865">
        <property type="entry name" value="Aminopep_P_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029149">
        <property type="entry name" value="Creatin/AminoP/Spt16_NTD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036005">
        <property type="entry name" value="Creatinase/aminopeptidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000994">
        <property type="entry name" value="Pept_M24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001131">
        <property type="entry name" value="Peptidase_M24B_aminopep-P_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05195">
        <property type="entry name" value="AMP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00557">
        <property type="entry name" value="Peptidase_M24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01011">
        <property type="entry name" value="AMP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53092">
        <property type="entry name" value="SSF53092"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55920">
        <property type="entry name" value="SSF55920"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00491">
        <property type="entry name" value="PROLINE_PEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0464">Manganese</keyword>
    <keyword evidence="2 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP_N" evidence="7">
        <location>
            <begin position="16"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM01011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PJN12121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="452" mass="49650" checksum="87170735936EBA42" modified="2018-04-25" version="1">MRTGWADTERRDLRPDEQAPYAAGRRAALSARFPGERLVIPSGKLKIRSNDSHYPFRPYSAYVHLTGDQARDSAIVFEPLEGGGHDVHLYLLPRDSRDTDEFWTGMTSELWMGRRRSLAESELVLGLPCRDVRDAAAELSAAPGAPTCIVRGHDPALEAAVTTAAERDAGLEEALSELRLVKDEWEIGELRKAVDSTVRGFTDVVRELATAIATSERWIEGTFFRRARLEGNAVGYGSICAAGEHATIMHWEQNDGPVRPGELLLLDAGVETHTLYTADVTRTLPISGTFTPLQRKIYDAVYEAQEAGIAAVKPGAAYRDFHDAAQRYMAGKLVEWGLLEGDPERVFELGLQRRFTMAGTGHMLGLDVHDCAAARTESYVGGPLEPGMVLTVEPGLYFQPDDLSVPQEYRGIGVRIEDDILVTADGTENLSAGLPRSADEVEAWMRTLAGDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JZ28</accession>
    <name>A0A2M9JZ28_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_09560</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN12120.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN12120">
        <property type="protein sequence ID" value="PJN12120"/>
        <property type="gene ID" value="CG723_09560"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13185">
        <property type="entry name" value="GAF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07228">
        <property type="entry name" value="SpoIIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00065">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00331">
        <property type="entry name" value="PP2C_SIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="SSF81606"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GAF" evidence="1">
        <location>
            <begin position="58"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="domain" description="PPM-type phosphatase" evidence="2">
        <location>
            <begin position="228"/>
            <end position="441"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN12120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="444" mass="47822" checksum="64AA172F3FA41C1B" modified="2018-04-25" version="1">MAGIERGIHPRQPHTPDLHERLRAELGRIDEQLRSLLDAMDRVQGLLDAVVSISREVELPAVLNRIVTTAMDLVGARYGAMGVLDESGDHLERFIAAGLSAQERAALAEAGFPRGMGVLGHLIHHPEPLRVESILSHPSSTGFPPGHPSMRTLLGVAISVRGEIYGDLYLSERRDGQPFDAHDENVVVALAGAAGIAIENVRLFERVRVGAEQFQRLLLPTLPDLRPFTAAAIYRPAAEPSQLGGDWYDAIPLSGNVVAVVIGDVVGHDLRAAASMASTRNMLRALLFEHGGAPAAVLAQLDRTLQAMTSNPITTTTLARIEPAGPGWRLHWSSAGHVPPLLIVPGRRAETLFAEPGLPLGVDPEQPRPDHSRYMPPDSTVVFFTDGLIEHPARPIDESLDELTALATLYAALPLPEFVQALADHHPSDGHDDMAVLALRTPPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-09-29" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JZ38</accession>
    <name>A0A2M9JZ38_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CG723_10020</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CB01635</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN12130.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN12130">
        <property type="protein sequence ID" value="PJN12130"/>
        <property type="gene ID" value="CG723_10020"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010290">
        <property type="entry name" value="TM_effector"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05977">
        <property type="entry name" value="MFS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="83"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="157"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="235"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="269"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="297"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="324"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="361"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="390"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="7">
        <location>
            <begin position="232"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="190"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PJN12130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="431" mass="44597" checksum="048CAA172F36ED93" modified="2018-04-25" version="1">MWRDRDFRRLWVGQTVSQLGEHTTLVVLPLCAVLTLGADAGELGVLRAVGQAPILLLSLPAGAWVDRWRTRTVMVLADAGRALALGATAVAGLFGALGLPALLVAAFAVGALSVFFDVAYQTSLARLVNRDQLVPGNSALEGSRSAAQIAGPALGGALVSVLAAPIAAASGALLFAMSFLSIRRIRRSEPIPEPTQERSQRLPEPTQEPRRRPPRVWRRIGEGLRFVVGDTSLRAVCLASAAFQFSLAAMMTVYLLFLPRELHLSGTEIGLALAATGPGALLGSLLAARLPGRFGHGVVLVSAAALGDGAFLIVPALHGSSTGTVLALVGVSLVFGTFGQLVNVTVMGVRQALTPDGMQGRAAATITFVGMGLTPLGSLLGGFLANGWGLRLSLAVTAAGMLLSPLLMALSPLARLGRTLPARGAPCPVRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JZ55</accession>
    <name>A0A2M9JZ55_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">AraC family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_11220</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN12154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN12154">
        <property type="protein sequence ID" value="PJN12154"/>
        <property type="gene ID" value="CG723_11220"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="1">
        <location>
            <begin position="136"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN12154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="255" mass="27225" checksum="82F88AD457FBC119" modified="2018-04-25" version="1">MAGFRARTTGLVDLGVVPYPAVTVAVDLGDGPIVVDDFSGRQQSGSVVLGLGSGGVRARGRDVECLQIRLSPLVAHAVLGAGAESGATVVSLDDLWGHDAARTQEQLRAAETWDDRFAVAQAALVRRHAAGRRAVEPEVAFVWRQMVTHRGGVRVERLAAEVGWSRKRLWSRFRAQIGLNPKRAAQLVRFDHAAHRLAVGHSAARVAAEIGYADQSHLHRDVMAFAGVTPTAVAVAPWLAVDDVAWAAPAYLSPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JZE8</accession>
    <name>A0A2M9JZE8_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">tRNA-dihydrouridine synthase</fullName>
            <ecNumber evidence="10">1.3.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CG723_04070</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">CB01635</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4 10">Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>a 5,6-dihydrouridine in tRNA + NAD(+) = a uridine in tRNA + H(+) + NADH</text>
            <dbReference type="Rhea" id="RHEA:54452"/>
            <dbReference type="Rhea" id="RHEA-COMP:13339"/>
            <dbReference type="Rhea" id="RHEA-COMP:13887"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74443"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 5,6-dihydrouridine in tRNA + NADP(+) = a uridine in tRNA + H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:23624"/>
            <dbReference type="Rhea" id="RHEA-COMP:13339"/>
            <dbReference type="Rhea" id="RHEA-COMP:13887"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74443"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3 10">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the dus family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.-" evidence="10"/>
    <dbReference type="EMBL" id="NNBL01000002">
        <property type="protein sequence ID" value="PJN12249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN12249">
        <property type="protein sequence ID" value="PJN12249"/>
        <property type="gene ID" value="CG723_04070"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017150">
        <property type="term" value="F:tRNA dihydrouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02801">
        <property type="entry name" value="DUS_like_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035587">
        <property type="entry name" value="DUS-like_FMN-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001269">
        <property type="entry name" value="DUS_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024036">
        <property type="entry name" value="tRNA-dHydroUridine_Synthase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004652">
        <property type="entry name" value="tRNA_dU_NifR3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018517">
        <property type="entry name" value="tRNA_hU_synthase_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01207">
        <property type="entry name" value="Dus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006621">
        <property type="entry name" value="Dus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00737">
        <property type="entry name" value="nifR3_yhdG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01136">
        <property type="entry name" value="UPF0034"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6 10" id="KW-0288">FMN</keyword>
    <keyword evidence="9 10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="7 10" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="Dus" evidence="12">
        <location>
            <begin position="18"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="11">
        <location>
            <position position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00002790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR006621"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR006621-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PJN12249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="376" mass="40454" checksum="36BA411C22EEC1A4" modified="2018-04-25" version="1">MSQQLTIGPHLVQPPVVLAPMAGITNAPFRTLCREYSGGKGLFVSEMITTRALVERNEKTMQLIRFDASEQPRSIQLYGVDPATVGKAVRMIAEEDLADHIDLNFGCPVPKVTRKGGGSALPYKRNLLRAILKEAVSGAGDLPVTMKMRKGIDDDHITFLDAGRIAVEEGVTAIALHGRTAAQHYGGTADWDAIARLKEHVPEIPVLGNGDIWCADDAVRMMRETGCDGVVVGRGCLGRPWLFGDLVAAFEGTGAPAAPDLRKVADAMVRHAGLLGEWIGDEARGVIDFRKHVAWYLKGFSVGSEMRKRLAVTSSLAELRAGLDELDLDQAWPVGADGPRGRTSGNNRVVLPDGWLKDPWDCAGVSEDAELDTSGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JZI5</accession>
    <name>A0A2M9JZI5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Glycosyl transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CG723_04355</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000002">
        <property type="protein sequence ID" value="PJN12295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN12295">
        <property type="protein sequence ID" value="PJN12295"/>
        <property type="gene ID" value="CG723_04355"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044249">
        <property type="term" value="P:cellular biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901576">
        <property type="term" value="P:organic substance biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028098">
        <property type="entry name" value="Glyco_trans_4-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13439">
        <property type="entry name" value="Glyco_transf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_4-like_N" evidence="4">
        <location>
            <begin position="43"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PJN12295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="383" mass="41768" checksum="735A3D24E38F6B4C" modified="2018-04-25" version="1">MPQHVPTPLRTPHPGDARPHPALPPPPRRIAFLARRDLGNPAAGGSELLVDRLADGLTRLGHEVTLLCGGPAAFRDYRVVSAGGDLGHYLRARSAFARQVGDCDLLVEVCNGMPYLAPLWHRGPTLRLVNHVHTDLWRMRFGGPLAPAARLGRRLEHWALSGAERRGLLVAVSPSTAAALRALGVERERIRVVHNGVEEPGPRADRSREPLFLAMGRLVEYKRIDLLLRLWERVRPVTGGRLLIVGDGPERERLEQLAGPGVEFRGHVSEAEKNRLLCEAWLLLHPSAVEGWGLVVTEAAARGTPAIGFDVPGLRDSVEDGVTGLLARGESSFAAAWCALALSGQRRRLMGKAAEERAATFRWAHTVRQFRAVAAEAVRSPAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-06-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JZY3</accession>
    <name>A0A2M9JZY3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CG723_05205</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000002">
        <property type="protein sequence ID" value="PJN12439.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN12439">
        <property type="protein sequence ID" value="PJN12439"/>
        <property type="gene ID" value="CG723_05205"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd11533">
        <property type="entry name" value="NTP-PPase_Af0060_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044548">
        <property type="entry name" value="AF0060_NTP-PPase_MazG-like"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PJN12439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="121" mass="13256" checksum="8E53E5B19C5F6391" modified="2018-04-25" version="1">MPDTTRPSARHDPAPPTYDSVWETVDGLHAWLDSHNRRTADEALLLRVLKLSEEVGEVAQAVIGATGQNPRKGESHSWQDVESELCDVVVTALVALRTLTPDAPEVLAAHLRRVAERSLTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K0H6</accession>
    <name>A0A2M9K0H6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">SAM-dependent methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_06170</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000002">
        <property type="protein sequence ID" value="PJN12614.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN12614">
        <property type="protein sequence ID" value="PJN12614"/>
        <property type="gene ID" value="CG723_06170"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013217">
        <property type="entry name" value="Methyltransf_12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08242">
        <property type="entry name" value="Methyltransf_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransf_12" evidence="1">
        <location>
            <begin position="39"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN12614.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="256" mass="26513" checksum="DAC3D1CE04E27B50" modified="2018-04-25" version="1">MSDPMRPRASLRTAVVWDVLKDALDRRVKATGRESLDVLDTGGGSGNFAVPVAGLGHRVTVVDPSPNALFALERRAAEAGVADRVRGVQGDVSGLFDVVERDGYDVVLCHGVLEYVDDPAEGVRNAVGALRSSGVLSLLAAGLGGAVLARALAGHFKEARQALGDPAGRWGDGDPVPRRFSAEQLTQLVGSAGVEVGAVHGVRVFADLVPGVLVDTEPGALQELLKLEAAAAEVPAFHSVATQLHVLGEKQGTPEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K0K6</accession>
    <name>A0A2M9K0K6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Export ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CG723_06365</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000002">
        <property type="protein sequence ID" value="PJN12646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN12646">
        <property type="protein sequence ID" value="PJN12646"/>
        <property type="gene ID" value="CG723_06365"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="8"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="46"/>
            <end position="53"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PJN12646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="323" mass="34147" checksum="94F0510C5DCFB700" modified="2018-04-25" version="1">MCVVRDLVRTYPATRGRRGAPGSAAIRATDGVSLEIRRGEIFGLLGPNGAGKSTLVRQLTGLMRPDSGSVGILGHDIVRYPERASRILAYLGQESSALDELTVSLAAETTGRLRGLDLRTARAERDAVVEELGLGAIASRPLKKLSGGQRRLACFAAALVGERPLLVLDEPTTGMDPVARRAVWAAVDRRRAESGATVVLVTHNVIEAETVLDRVAVLDRGRVIACDTPAGLKEKVAGEVRVELVWRERAPLDVPAVAALRAVAVESGRRWSLRLGPDEARAAVAAVTGGPAFAALDDFSLTTPSLEDVYLALGGEAKGLVKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K107</accession>
    <name>A0A2M9K107_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Amidohydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_07295</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000002">
        <property type="protein sequence ID" value="PJN12809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN12809">
        <property type="protein sequence ID" value="PJN12809"/>
        <property type="gene ID" value="CG723_07295"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04909">
        <property type="entry name" value="Amidohydro_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydro-rel" evidence="1">
        <location>
            <begin position="147"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN12809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="376" mass="39399" checksum="A30381B709ABF9D2" modified="2018-04-25" version="1">MIDTPSLVDQYCHGVLRTELGLGTFEAHLGRGDRPPAPGTTFFDTQTGFAVRRWCPPLLGLEPHCPPARYLARRRELGVLESGRRLLRGSGITTYLVDTGLPGDLTGPREMASVGDADAHEIVRLELLAEQVADTSGTVESLLANLAESVHAAAANAVAFTSVAGVRHGLAFAPQPPGPGEVRGAAGRWLAARRVGGPLTDPVLLRHLLWIAVASGRPLQLHAGLGEPGLRLDRTDPVLLTDFARATAGLGTDLILLHGYPYHRHAAHLAGIFPHVYADLGPALARTGARAAAVLAEILELAPFGKLLFSSGAHGLPELHVVGARLFREALGRVLGGWVSEGAWSLADAQRVAGMIGSVTAQRVYGLSGTGAAQGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K111</accession>
    <name>A0A2M9K111_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Glutamate synthase</fullName>
            <ecNumber evidence="6">1.4.1.13</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">gltD</name>
        <name evidence="6" type="ORF">CG723_07045</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CB01635</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="4">Amino-acid biosynthesis.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.4.1.13" evidence="6"/>
    <dbReference type="EMBL" id="NNBL01000002">
        <property type="protein sequence ID" value="PJN12760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN12760">
        <property type="protein sequence ID" value="PJN12760"/>
        <property type="gene ID" value="CG723_07045"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00124"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004355">
        <property type="term" value="F:glutamate synthase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006537">
        <property type="term" value="P:glutamate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1060.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028261">
        <property type="entry name" value="DPD_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006005">
        <property type="entry name" value="Glut_synth_ssu1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009051">
        <property type="entry name" value="Helical_ferredxn"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14691">
        <property type="entry name" value="Fer4_20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01317">
        <property type="entry name" value="GOGAT_sm_gam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="3" id="KW-0314">Glutamate biosynthesis</keyword>
    <keyword evidence="2 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="5">
        <location>
            <begin position="38"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00029440"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PJN12760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="496" mass="53292" checksum="19A1F53AFC587E14" modified="2018-04-25" version="1">MADPKGFLTTPREDWPRRPVGERVQDWDEVYVPGALLPIVEAQADRCMDCGVPFCHEACPLGNLIPDWNDLVSRDDWRAASDRLHATNNFPEFTGRLCPAPCEAGCVLAINQPAVTIKNVEVAIADRAWQDGLAPPKPPERLSGRTVAVVGSGPAGLAAAQQLTRAGHTVAVFERDDRPGGLMRYGIPAFKMEKHHLDRRLAQLRDEGVRFRTSTEVGRDIGAAELRSRYDAVVLAVGATAWRELHVPGRELDGIVQAMEYLPLANRVCQGDLDVSPLSAAGKHVVIVGGGDTGADCLGTAVREGAASVTQLDIYGQPGAERDELAEPWPTYPKIYRMSAAHEEAGELRTAPAADADARLFAASTLRFEGDEWGRVRALHLVEVDEARRPREDTSRELPADLVLLALGFSGPERGAGGPVGQLGLAVEDRGTLTRDARFTTSVPGVFAAGDAARGQSLIVWAIAEGRSAAAAVDHWLTGSTRLPAPIGPYDRPMTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K132</accession>
    <name>A0A2M9K132_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 9">4-hydroxy-tetrahydrodipicolinate synthase</fullName>
            <shortName evidence="9">HTPA synthase</shortName>
            <ecNumber evidence="4 9">4.3.3.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9 11" type="primary">dapA</name>
        <name evidence="11" type="ORF">CG723_07400</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CB01635</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 9">Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>L-aspartate 4-semialdehyde + pyruvate = (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate + H(+) + H2O</text>
            <dbReference type="Rhea" id="RHEA:34171"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:67139"/>
            <dbReference type="ChEBI" id="CHEBI:537519"/>
            <dbReference type="EC" id="4.3.3.7"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 9">Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; (S)-tetrahydrodipicolinate from L-aspartate: step 3/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Homotetramer; dimer of dimers.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9 10">Belongs to the DapA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Was originally thought to be a dihydrodipicolinate synthase (DHDPS), catalyzing the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to dihydrodipicolinate (DHDP). However, it was shown in E.coli that the product of the enzymatic reaction is not dihydrodipicolinate but in fact (4S)-4-hydroxy-2,3,4,5-tetrahydro-(2S)-dipicolinic acid (HTPA), and that the consecutive dehydration reaction leading to DHDP is not spontaneous but catalyzed by DapB.</text>
    </comment>
    <dbReference type="EC" id="4.3.3.7" evidence="4 9"/>
    <dbReference type="EMBL" id="NNBL01000002">
        <property type="protein sequence ID" value="PJN12828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN12828">
        <property type="protein sequence ID" value="PJN12828"/>
        <property type="gene ID" value="CG723_07400"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00034">
        <property type="reaction ID" value="UER00017"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008840">
        <property type="term" value="F:4-hydroxy-tetrahydrodipicolinate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019877">
        <property type="term" value="P:diaminopimelate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009089">
        <property type="term" value="P:lysine biosynthetic process via diaminopimelate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00950">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00418">
        <property type="entry name" value="DapA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005263">
        <property type="entry name" value="DapA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002220">
        <property type="entry name" value="DapA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020625">
        <property type="entry name" value="Schiff_base-form_aldolases_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020624">
        <property type="entry name" value="Schiff_base-form_aldolases_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12128">
        <property type="entry name" value="PTHR12128"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00701">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001365">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00146">
        <property type="entry name" value="DHPICSNTHASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01130">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00674">
        <property type="entry name" value="dapA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00665">
        <property type="entry name" value="DHDPS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00666">
        <property type="entry name" value="DHDPS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 9" id="KW-0220">Diaminopimelate biosynthesis</keyword>
    <keyword evidence="9 10" id="KW-0456">Lyase</keyword>
    <keyword evidence="7 9" id="KW-0457">Lysine biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 9" id="KW-0704">Schiff base</keyword>
    <feature type="active site" description="Proton donor/acceptor" evidence="9">
        <location>
            <position position="154"/>
        </location>
    </feature>
    <feature type="active site" description="Schiff-base intermediate with substrate" evidence="9">
        <location>
            <position position="182"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="66"/>
        </location>
        <ligand>
            <name>pyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="222"/>
        </location>
        <ligand>
            <name>pyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
        </ligand>
    </feature>
    <feature type="site" description="Part of a proton relay during catalysis" evidence="9">
        <location>
            <position position="65"/>
        </location>
    </feature>
    <feature type="site" description="Part of a proton relay during catalysis" evidence="9">
        <location>
            <position position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR001365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PJN12828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="314" mass="32387" checksum="D9911ADFF7D329B0" modified="2018-04-25" version="1">MELHGRGAETAPMSLANSPHPPFGRALCAMVTPFADDGALDLDGAQRLAAHLVAEGCEGLVLSGTTGESPTTSDAEKAALVRAVKDAVGERVPVVAGIGTADTRHTVELAAGAEKAGADGLLVVSPYYSRPPQDALEAHFREIADASGLPVMLYDIPGRTGTRIEPDTLIRLASHPRIVAVKDCAYDMLGTQKVLGATGLAYYAGCEEFALPLYAVGGAGFVSTVANVAPRALRAVLDTFDAGDTREAARRQQLAAPLVELIMASGLPGTVTAKALLGALGLPAGPVRAPLRPAGHEVTDGLLTAYESFVNAWC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-05-25" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K1D6</accession>
    <name>A0A2M9K1D6_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Phosphoserine phosphatase</fullName>
            <ecNumber evidence="6">3.1.3.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">O-phosphoserine phosphohydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="primary">serB</name>
        <name evidence="15" type="ORF">CG723_07995</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">CB01635</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>H2O + O-phospho-D-serine = D-serine + phosphate</text>
            <dbReference type="Rhea" id="RHEA:24873"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:35247"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58680"/>
            <dbReference type="EC" id="3.1.3.3"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>H2O + O-phospho-L-serine = L-serine + phosphate</text>
            <dbReference type="Rhea" id="RHEA:21208"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57524"/>
            <dbReference type="EC" id="3.1.3.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">Amino-acid biosynthesis; L-serine biosynthesis; L-serine from 3-phospho-D-glycerate: step 3/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the HAD-like hydrolase superfamily. SerB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.3" evidence="6"/>
    <dbReference type="EMBL" id="NNBL01000002">
        <property type="protein sequence ID" value="PJN12936.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN12936">
        <property type="protein sequence ID" value="PJN12936"/>
        <property type="gene ID" value="CG723_07995"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00135">
        <property type="reaction ID" value="UER00198"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036424">
        <property type="term" value="F:L-phosphoserine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006564">
        <property type="term" value="P:L-serine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002912">
        <property type="entry name" value="ACT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004469">
        <property type="entry name" value="PSP"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00029">
        <property type="entry name" value="phosphoserine_phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="SSF55021"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00338">
        <property type="entry name" value="serB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51671">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0718">Serine biosynthesis</keyword>
    <feature type="domain" description="ACT" evidence="14">
        <location>
            <begin position="24"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="13">
        <location>
            <position position="198"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="13">
        <location>
            <position position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00009184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00031693"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR604469-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="PJN12936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="412" mass="43507" checksum="C49613760969B32F" modified="2018-04-25" version="1">MSASQPRHPADVPVAVPDDVPTLLVKIFGKDRPGITAGLFDTLAAYSVDVVDIEQVVTRGRIVLCALVTEPPPGLEGDLRSTVHSWAESMRMQAEIISGIGDNRPRGLGRSLVTVLGHPLTAETTAAIAARITGTGGNIDRIFRLAKYPVTAVEFAVSGAETEPLRTALATESAALGVDVAVVAAGLHRRAQRLVVMDVDSTLIQDEVIELFAAHAGCEDKVAEVTASAMRGELDFEQSLHARVALLAGLDASVVDKVRTEVRLTPGARTLIRTLKRLGYQVGVVSGGFTQVTDDLQDRLGLDFAQANTLEIVDGKLTGRVTGEIVDRAGKARLLRRFAAEAGVPLAQTVAIGDGANDLDMLNAAGLGVAFNAKPVVREAAHTAVNVPFLDTVLYLLGITREEVEAADAHDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K1I8</accession>
    <name>A0A2M9K1I8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Short-chain dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_08020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000002">
        <property type="protein sequence ID" value="PJN12940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN12940">
        <property type="protein sequence ID" value="PJN12940"/>
        <property type="gene ID" value="CG723_08020"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN12940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="233" mass="24148" checksum="CE3AEE5A3FD92E86" modified="2018-04-25" version="1">MPVAIITGASKGFGRALAVALARHGWDLVLDARSGAVLREAADEAGRYGTRVEALPGDVTDTAHRAELVAAARGLGGLDLLVNNASALGAEPLVRLDALPVEGLRRALEVNVVAALGLVQEALPLLRGSAGGAVVSVSSDASAEAYETWGGYGASKAALDQLSAVLAVEEPGLRVWAVDPGDMRTDLYRAAAPLDDDSDRPLPETVVPAFLRLLDERPDSGRYAAPSLLLEAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K1K3</accession>
    <name>A0A2M9K1K3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ATP-dependent protease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_06385</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000002">
        <property type="protein sequence ID" value="PJN13004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN13004">
        <property type="protein sequence ID" value="PJN13004"/>
        <property type="gene ID" value="CG723_06385"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.130.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003111">
        <property type="entry name" value="Lon_prtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046336">
        <property type="entry name" value="Lon_prtase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02190">
        <property type="entry name" value="LON_substr_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00464">
        <property type="entry name" value="LON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="SSF88697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51787">
        <property type="entry name" value="LON_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lon N-terminal" evidence="1">
        <location>
            <begin position="6"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN13004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="260" mass="27410" checksum="CC5A508393E5554F" modified="2018-04-25" version="1">MTTVRLPLFPLNSVLFPGLVLPLNVFEERYRAMMRDLLKTSSGGSEASGDPTDSDEPRRFAVVAIRDGHEVAPSAPGMPDQAAKTAAEAGPAAGFGDDPIKALHGVGCIADAATIRERADGSFEVLATGTTRVKVHSVDASGAYLTAEVEELPEEPGDEAGALAEGVLRAFRSYQKRLAGARERSLATGADLPDDPSVVSYLVAAAAVLDVPTKQRLLQAPDTASRLRDELKLLRAETAIIRNLPSLPAGDLTRQATSLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K1Q4</accession>
    <name>A0A2M9K1Q4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MBL fold metallo-hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_00105</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000001">
        <property type="protein sequence ID" value="PJN13049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN13049">
        <property type="protein sequence ID" value="PJN13049"/>
        <property type="gene ID" value="CG723_00105"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038536">
        <property type="entry name" value="Alkyl/aryl-sulf_dimr_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029228">
        <property type="entry name" value="Alkyl_sulf_dimr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14863">
        <property type="entry name" value="Alkyl_sulf_dimr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lactamase_B" evidence="1">
        <location>
            <begin position="54"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN13049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="463" mass="50841" checksum="2C1AACCD6BBEBD6A" modified="2018-04-25" version="1">MTEHKERGTQHAAYADYIDQVWQGTETLLPHLTGTYSGSELVRLRDRVGFFPAFANVAAFDTGDGVVLVDSGDFRTADQLHEAVTGFGAGPLRSVVYTHGHVDHVFGVAPFDQEADEIGGPRPEVIAHEAVPARFDRYIKTADYNSWINRRQFGVPSLEWPTTYRYPDVVYRDRLTVRRGELTFELVHARGETDDHTYVWIPELRTLCTGDLFIWNAPNAGNPQKVQRYPEDWARALRAMQELGAELLLPGHGVPVVGSDRVHQALDDTARLLESLCEQTRELMNAGHRLDAVIHGVKAPEDLLAKPYLHPAYDEPEFVVRNLWRLWGGWYDQNPAHLKPAPEADVAAEFARAAGGASALALRASELLAAGELRLASHLAETAALAAPADQEVARVRADVFAQRALQETSTMARGVFHWAAAESAAAAAGTDVQTELTRSPAGRKRAEGAISVGVVDDEDGCC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K1Q7</accession>
    <name>A0A2M9K1Q7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_00240</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000001">
        <property type="protein sequence ID" value="PJN13072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN13072">
        <property type="protein sequence ID" value="PJN13072"/>
        <property type="gene ID" value="CG723_00240"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="61"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="87"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="130"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN13072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="155" mass="16319" checksum="8C3527936457DE3B" modified="2018-04-25" version="1">MEAGPRDTAPGGEQLSPDGPDATPDGVIADGPTAEELASQTGGAEVEVELRPQRRLRLWQLAPIVILSAIGSLMFAFPLFFEFGDGGAVVAMLGLLISSCAAGWGMMAARRVGYTWPGFPARGSGRRPDWRVVGAYAVVVAAVAVLAVWRVARLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K277</accession>
    <name>A0A2M9K277_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DNA-binding response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CG723_01190</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000001">
        <property type="protein sequence ID" value="PJN13234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN13234">
        <property type="protein sequence ID" value="PJN13234"/>
        <property type="gene ID" value="CG723_01190"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00622">
        <property type="entry name" value="HTH_LUXR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="20"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="domain" description="HTH luxR-type" evidence="3">
        <location>
            <begin position="152"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PJN13234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="220" mass="22799" checksum="A3F4CF386362E894" modified="2018-04-25" version="1">MSVLLEQPASLVAYRPNKPTAMVVVADPRVRSTVTRHLWALGVRDVIEASSVAEARPRIGNPRDICVADVHLPDGSGLTLLSETRAAGWPNGLALSAADDIGAVRNALAGGVKGYVVTGTRTNVGLPSRPGAAPIGSAAARMHRRPPGAPSHPGGYRELSGREVEVLRLVAEGQSNKAIGVSMGLSALTVKSHLARIARKLGTGDRAGMVAVALRTGIIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K2D4</accession>
    <name>A0A2M9K2D4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CG723_01510</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000001">
        <property type="protein sequence ID" value="PJN13288.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN13288">
        <property type="protein sequence ID" value="PJN13288"/>
        <property type="gene ID" value="CG723_01510"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045697">
        <property type="entry name" value="DUF5919"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041334">
        <property type="entry name" value="HEPN_SAV2148"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19319">
        <property type="entry name" value="DUF5919"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18725">
        <property type="entry name" value="HEPN_SAV2148"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HEPN_SAV2148" evidence="2">
        <location>
            <begin position="36"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="domain" description="DUF5919" evidence="3">
        <location>
            <begin position="266"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="13"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF18725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF19319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PJN13288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="428" mass="47095" checksum="01544919DBF51624" modified="2018-04-25" version="1">MLGGAEGGAWVSSGGLELPPGDAGHEGSSADVPPGAVSLARPMDMGSQIGPESEFAWGADAWSEVRTRAQRAGRAYIWLNLVEQRLRAVVAAVLRPIYEPVHGDDWVVAAAGPAGQEWVQRAVAVREVSRRKGYLLDPADDNVLSFLTLPQLRELMVQHWPCFEPYFDDRRDVELALDELEVTRNVVSRNRALSEAVLAQAERASGRLLEMLGAGSDVPSGRRLPVDAVEELVGDRYADVVGVHPDRVRLLRQFPAEDIFGGARRLDAIGIGLNMLVQNFSGRRLVRLAESGCRVRLLFLNPASSAVKRRERELGLKRGELSRAVEMNILHMRRVRARLRDPGAFEIQVYDETPRFTAYLVDGDGSDGVGVVQSYLRRARGMEAPVLVLRGPGRVVKANSPHDGEEAGLFPTYREEFELAWADARPVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K2F2</accession>
    <name>A0A2M9K2F2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">TetR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CG723_01050</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000001">
        <property type="protein sequence ID" value="PJN13207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN13207">
        <property type="protein sequence ID" value="PJN13207"/>
        <property type="gene ID" value="CG723_01050"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="3">
        <location>
            <begin position="20"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="42"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PJN13207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="196" mass="20721" checksum="BA25B24045166CDD" modified="2018-04-25" version="1">MNDSGQGTGGAAGSKRKDARRNQQTLLDAAAAVFVASGVEAPVRDIAAKAGVGMGTIYRHFPTRADLVIAVYRHQVEACAEAGPALLAAAPTPHVALGRWVDLFVDFLVTKHGLAGAMQADNAGFETLHAYFLDRLVPVCTQLIDAAVASGEIRADLDAYQLMRGIGNLCIGAENDPRYDARRLVGLLVAGLREPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K2L1</accession>
    <name>A0A2M9K2L1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CG723_01930</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000001">
        <property type="protein sequence ID" value="PJN13362.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN13362">
        <property type="protein sequence ID" value="PJN13362"/>
        <property type="gene ID" value="CG723_01930"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PJN13362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="253" mass="26771" checksum="EA69A3A96B364CB8" modified="2018-04-25" version="1">MSGSGTTAGDDPLQTAVWRLRSRACWTDAAALLERLAATDARAALQRAALLGERCLYTEQGWAAAEDALRAAEALAHDDGERGAAACERGQLAYSATLLGVRDRADEARSALGRAAALLPPGAPGRALLDFRRGLMAENLSDSPQAARAAYRRAHAGATAHPDPLLLSFTWRHLAGLALREGELTEARHGFAESLRIREELGYLVGTAPALASLAEAEPDPEAAARLRAEASRLFRLLGGVPTWLAEHLPTAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K2P7</accession>
    <name>A0A2M9K2P7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glyoxalase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_01805</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000001">
        <property type="protein sequence ID" value="PJN13340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN13340">
        <property type="protein sequence ID" value="PJN13340"/>
        <property type="gene ID" value="CG723_01805"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004360">
        <property type="entry name" value="Glyas_Fos-R_dOase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00903">
        <property type="entry name" value="Glyoxalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VOC" evidence="1">
        <location>
            <begin position="7"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN13340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="136" mass="14504" checksum="1A9EA5B5FCDF1AF6" modified="2018-04-25" version="1">MTEITARLDAVGVVVSDMAAAVTFYRRLGLAFPDGAEEQPHAEAVLPGGLRVLLDTEETVKSFHPSWRAPARGASRHGLAFHCGDAAGVDAVYEELTAAGYDGELKPWDAFWGQRYAVVFDPDGNGVDLFAPLATA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K2P9</accession>
    <name>A0A2M9K2P9_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">5-hydroxyisourate hydrolase</fullName>
            <shortName evidence="6">HIU hydrolase</shortName>
            <shortName evidence="6">HIUHase</shortName>
            <ecNumber evidence="6">3.5.2.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">uraH</name>
        <name evidence="8" type="ORF">CG723_02145</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CB01635</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the hydrolysis of 5-hydroxyisourate (HIU) to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>5-hydroxyisourate + H2O = 5-hydroxy-2-oxo-4-ureido-2,5-dihydro-1H-imidazole-5-carboxylate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23736"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:18072"/>
            <dbReference type="ChEBI" id="CHEBI:58639"/>
            <dbReference type="EC" id="3.5.2.17"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 6">Belongs to the transthyretin family. 5-hydroxyisourate hydrolase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.2.17" evidence="6"/>
    <dbReference type="EMBL" id="NNBL01000001">
        <property type="protein sequence ID" value="PJN13399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN13399">
        <property type="protein sequence ID" value="PJN13399"/>
        <property type="gene ID" value="CG723_02145"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033971">
        <property type="term" value="F:hydroxyisourate hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006144">
        <property type="term" value="P:purine nucleobase metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05822">
        <property type="entry name" value="TLP_HIUase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014306">
        <property type="entry name" value="Hydroxyisourate_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023418">
        <property type="entry name" value="Thyroxine_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023416">
        <property type="entry name" value="Transthyretin/HIU_hydrolase_d"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036817">
        <property type="entry name" value="Transthyretin/HIU_hydrolase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10395">
        <property type="entry name" value="PTHR10395"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00576">
        <property type="entry name" value="Transthyretin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49472">
        <property type="entry name" value="SSF49472"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02962">
        <property type="entry name" value="hdxy_isourate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00768">
        <property type="entry name" value="TRANSTHYRETIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 6" id="KW-0659">Purine metabolism</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TR_THY" evidence="7">
        <location>
            <begin position="9"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PJN13399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="134" mass="14225" checksum="DD9595959AF8DA9E" modified="2018-04-25" version="1">MSTATTASVSTHILDTSIGRPAEGVAISLAARSGSDAEWVALGGSATDADGRCKDLPALPEGTTHVRLDFAVETYFTRSIKTVKQAEAQQDAPRVRDSGAFFPEVAITFAVKPGEHYHVPLLLNPFGYSVYRGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K2Q6</accession>
    <name>A0A2M9K2Q6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Thioesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CG723_02200</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000001">
        <property type="protein sequence ID" value="PJN13408.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN13408">
        <property type="protein sequence ID" value="PJN13408"/>
        <property type="gene ID" value="CG723_02200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="SSF54637"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PJN13408.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="140" mass="15715" checksum="9D7486B19864EBE2" modified="2018-04-25" version="1">MAETFTVRIQVRGYETDSQGHLNQSVYLQYAEHARWVLLQHGGIRQADLLAKGVGPVALETTIRYRRELRAGDEVDVSCAFVWTEGKTFRVEQSIRKTDGTLAAELTSAGGLMDLKERKLVADPREYFRALASDPRAFGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-05-25" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K2R5</accession>
    <name>A0A2M9K2R5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">ATP-dependent helicase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CG723_02215</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000001">
        <property type="protein sequence ID" value="PJN13411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN13411">
        <property type="protein sequence ID" value="PJN13411"/>
        <property type="gene ID" value="CG723_02215"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140658">
        <property type="term" value="F:ATP-dependent chromatin remodeler activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022138">
        <property type="entry name" value="Helicase_SWF/SNF-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12419">
        <property type="entry name" value="DUF3670"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0347">Helicase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="2">
        <location>
            <begin position="503"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="3">
        <location>
            <begin position="786"/>
            <end position="945"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="232"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PJN13411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="954" mass="102106" checksum="3B69D3C7AEEE2618" modified="2018-04-25" version="1">MTEQIDHRGITVAAAAVFLPAPLPRESSVAFWHPDGTDLPGATPLTVVRPHGTGARARTVPAVRLPVTDALPLLVRARHTPGAHPAAACWGAAALHALHLVGRGRLLPGLTPSDHDAWRAGPLDADDIAQLRAIAAAMPYEAHAAPVEGSKPLRLPEPEALVRAFLDAVADSLPRSPAAPFAAGAPFASFAPQHLPRARAWAVEAAAGMDAGVRVSLRLDLSNFTLFDTDDAADATDPASAGEDGPGGPGAEERRRAGAALVQVHSLADPTQVVDAARLWAGDGDAHFGPRARIDAVLALRRAARVWPPLGRVLERDVPDVLALSEGELLDLLGPAAARLADAGVEVHWPRDLARALTATAVVRAAAPGSATDGTPFFDGEELLKFNWQLALDGDPLSEREMDELAESHRPVVRLRDQWVVVDPDLVRKARKRELGLLQPVDALAVALTGEADIDGERVEAVPTGVLAHLRDRLVEGPAAVTQPAGLHATLRDYQLRGLAWLDLMTSLGLGGCLADDMGLGKTVTLIALHLRRNKAAPTLVVCPASLLGNWQREISRFAPGVPVRRFHGTDRTLDGLAGGFVLTTYGTLRTRAAELAGHTWGMVVADEAQHIKNPFSATAKALRSIPSPARIALTGTPVENNLSELWALLDWTTPGLLGPLKSFRARHARAVETGEDAEAVERLARLVRPFLLRRKKSDPGIVPELPPKTESDHPAPLTREQASLYEAVVRETMAEIEAAEGIARRGLIMKLLTSLKQICNHPAQFLKETEGPRARLTGRSGKLALLDELLDTILAEDGSVLVFTQYVSMARLLATHLAARAIPSQLLHGGTPVAERERMVDRFQSGEVPVFLLSLKAAGTGLNLTRAGHVVHFDRWWNPAVEEQATDRAYRIGQTQPVQVHRLITEGTVEDRIAEMLAAKKALADAVLGSGEAALTELTDRELADLVSLRRTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K308</accession>
    <name>A0A2M9K308_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Peptide ABC transporter substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_02820</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000001">
        <property type="protein sequence ID" value="PJN13514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN13514">
        <property type="protein sequence ID" value="PJN13514"/>
        <property type="gene ID" value="CG723_02820"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027476">
        <property type="entry name" value="DppA_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007035">
        <property type="entry name" value="Peptidase_M55"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036177">
        <property type="entry name" value="Peptidase_M55_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04951">
        <property type="entry name" value="Peptidase_M55"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015853">
        <property type="entry name" value="Pep_DppA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63992">
        <property type="entry name" value="SSF63992"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="active site" description="Nucleophile" evidence="1">
        <location>
            <position position="116"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="8"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="10"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="60"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="105"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="135"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR015853-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR015853-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN13514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="277" mass="29816" checksum="56E8228A852B688F" modified="2018-04-25" version="1">MKILISADMEGATGVTWPGDVLPGTPQWERCRSMFTSDVNAAVLGFFDGGADEVLINEAHWSMRNLLLEQLDERAEMITGRHKTLSMVEGVQHGDVDGIAFIGYHTGAGTEGVLAHTYLANSITGVWINGVRASEGLLNAHVVAEYGVPVVLVTGDDLTCDDALGYAPEARKVAVKDYVSRYAAVCRTPKRTAADIRAAAKEAAALAVRHEPVEGGPFTIELEFDAEHLSMAATVVPGVRRTGERRVSYTNDTMYDGIRTFKAVTTIVSAAVEEQYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K329</accession>
    <name>A0A2M9K329_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Thioesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_02375</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000001">
        <property type="protein sequence ID" value="PJN13437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN13437">
        <property type="protein sequence ID" value="PJN13437"/>
        <property type="gene ID" value="CG723_02375"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003736">
        <property type="entry name" value="PAAI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006683">
        <property type="entry name" value="Thioestr_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03061">
        <property type="entry name" value="4HBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="SSF54637"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00369">
        <property type="entry name" value="unchar_dom_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4HBT" evidence="1">
        <location>
            <begin position="57"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN13437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="148" mass="15705" checksum="1280B8B845414FE0" modified="2018-04-25" version="1">MTAPRDSDSPHELDFALAVKLLDAQPFTRLVGARLTEFGDGVATIEVDIRPELHQQNGFLHGGVLSYAADNALTFAGGAVLGAAVLTGGFSIQYVRPATGRTLIARAQVMHRGRRQAVVRCDLSTADEEGTEKLCALAQGTILSVTQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K3H0</accession>
    <name>A0A2M9K3H0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">1-hydroxy-2-methyl-2-butenyl 4-diphosphate reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_03775</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000001">
        <property type="protein sequence ID" value="PJN13673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN13673">
        <property type="protein sequence ID" value="PJN13673"/>
        <property type="gene ID" value="CG723_03775"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009116">
        <property type="term" value="P:nucleoside metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1580">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000845">
        <property type="entry name" value="Nucleoside_phosphorylase_d"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035994">
        <property type="entry name" value="Nucleoside_phosphorylase_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01048">
        <property type="entry name" value="PNP_UDP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53167">
        <property type="entry name" value="SSF53167"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PNP_UDP_1" evidence="1">
        <location>
            <begin position="13"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN13673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="219" mass="22814" checksum="BD3BEFD2D1B1A35E" modified="2018-04-25" version="1">MTGSPAAPRPPDAAPLLVACALGIEYFALRTGARTGAPAHVTVLRTGMGPRAAERSVAKALEDPALHDAAVVATGFCAGLAPGMHPGDLVVAEETRDPYGSTPCTGTELLVKELVRAVPGRTVHTGPLTGSDHVVRGHERGDLLATGAIAVDMESAATLRTAAARGPRPVAAVRVVVDAPEHELVRISTVRGGISAFRVLRAVLPAFFEWHRSLLLPRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K3N5</accession>
    <name>A0A2M9K3N5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Phenoxazinone synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CG723_01440</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000001">
        <property type="protein sequence ID" value="PJN13744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN13744">
        <property type="protein sequence ID" value="PJN13744"/>
        <property type="gene ID" value="CG723_01440"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011706">
        <property type="entry name" value="Cu-oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045087">
        <property type="entry name" value="Cu-oxidase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011707">
        <property type="entry name" value="Cu-oxidase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033138">
        <property type="entry name" value="Cu_oxidase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002355">
        <property type="entry name" value="Cu_oxidase_Cu_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709">
        <property type="entry name" value="PTHR11709"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07731">
        <property type="entry name" value="Cu-oxidase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07732">
        <property type="entry name" value="Cu-oxidase_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="SSF49503"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00079">
        <property type="entry name" value="MULTICOPPER_OXIDASE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00080">
        <property type="entry name" value="MULTICOPPER_OXIDASE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Plastocyanin-like" evidence="4">
        <location>
            <begin position="70"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="4">
        <location>
            <begin position="141"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="3">
        <location>
            <begin position="472"/>
            <end position="607"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF07732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PJN13744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="629" mass="68498" checksum="2154D1256B3B4B9E" modified="2018-04-25" version="1">MTDIIERITDGLAGAARDSAPAAADGELAPYVAPLTVPPVLRPDSTDVLRETEIALRPTWVRLHPQLPPTLMWGYGGSVPGPTIEVRRGQRVRIAWTNRIPKGSEYPVTAVEVPAANPNPSTEPGRDGVPPIADVAALPAWTVTHLHGAQTGGGNDGWADNAVGYGDAQLSEYPNDHQAVQWWYHDHAMNVTRWNVHTGLYGTYLVRDDEEDALQLPSGEREIPLLVADRNLDTDEDGALNGRLLHKTVIVQEKNPETGKPVSVPFAGPYTTVNGRIWPYAEVDAAWHRFRLVNASNARIYDLVLIDEDDNPVPGVLHQIGSDGGLLPRPVPVDFDEALPTLTVAPAERMDLLIDFRALAGRRVRLVNKGAGQAPGVPDPANNVRYPHVMEFRVGECGADDPFELPEVLSGSFRRLTHDIEHGHRLIVLTPPATKGGGGHPEIWEMTEVEGEVEVPADGVIQLRGANGTSKTYRRTSRTFNDGLGFTVAEGSYEQWSFLNLAVNPPVVHPMHIHLADFQILGRDTYDVSGFDVTAGGTRVPLAPDPATPVPLPPNERGYKDVFRALPGQMLRVMGRFDGAYGRFMYHCHLLEHEDMGMMRPFVVMPAEAMKFDHGAGHGGHGGHGGHGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JEK2</accession>
    <name>A0A2M9JEK2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">TetR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_45455</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000054">
        <property type="protein sequence ID" value="PJN05325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN05325">
        <property type="protein sequence ID" value="PJN05325"/>
        <property type="gene ID" value="CG723_45455"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011075">
        <property type="entry name" value="TetR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16859">
        <property type="entry name" value="TetR_C_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="15"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="38"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN05325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="189" mass="20408" checksum="FF90EE84E6196492" modified="2018-04-25" version="1">MDEQQRTRRPGGRSARVGAAVHQAVTDLVGERGYGGFTVSEVAARAGVADTTVYRRWGSLEALLTDVTLTRLNARSPMPDTGDLVGDLRTYAAAVAREITGPDGLAVLRLAVVLSGSGPEGLRLRDGFLAERARRLQSMLDRARERGERPPDALAVVDHVMAPMYIRVLFGAGPLTAEYVEGLVDRLLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JEN8</accession>
    <name>A0A2M9JEN8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CG723_45155</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000051">
        <property type="protein sequence ID" value="PJN05360.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN05360">
        <property type="protein sequence ID" value="PJN05360"/>
        <property type="gene ID" value="CG723_45155"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025161">
        <property type="entry name" value="Put_IS4/IS5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13340">
        <property type="entry name" value="DUF4096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PJN05360.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="85" mass="9874" checksum="F563D354DFF8342E" modified="2018-04-25" version="1" fragment="single">SQPSHQRQLDFLPSSDVCGSDPGWTRRAYLPGWVSWRDLPERYGPWQTVYTRFRRYAQCRMLGDNPAVALRILVDGQVILCWACC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-09-29" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JFD6</accession>
    <name>A0A2M9JFD6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_44120</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000045">
        <property type="protein sequence ID" value="PJN05589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN05589">
        <property type="protein sequence ID" value="PJN05589"/>
        <property type="gene ID" value="CG723_44120"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="429"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="469"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="589"/>
            <end position="622"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN05589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="745" mass="81336" checksum="36CFFA8632A3AD81" modified="2018-04-25" version="1">MAPGGQGPGTVVVTGLAGIGKTALALHTAHQAITNGLFAGGTLFLGLRGYAPAGAVSAGQALEALLRALGIRDHDLPPTVEEQASLYQSELARRAEEHGPVLVFADDASTTGQLLPLVPSHPGHRLLATSRDALTGPNLPTRLIPLDQLAPRQAASLITNTLTRTRPSDPRPGKEPRALEQVAEHCGHLPLALTIAAAQLADDPGLPIATLADDLANTRNRLEALHYQDGDGRSPAVRAAFDLSYRRLEDRHALLFRLLALNPGPDLATEAAAALSGQAARQTRESLAALARTSLISEAPIGSGRWRMHDLINLYAADLNHHHDNDRALQRLLEHYCTVTEAADAHLRALPGQPVPERFSDRTAALTWLDAERPNLTAAAGMGHSRTTGSLAAGLAVYLDRRRYFQDAIATGHHAVTMARQVGARHNEGTALGNLGGALYRVRRFDDAIDAFTRAVDIFRELGDRHREGGVLNNLGLTLREVRRFEDAIGTFTRAIDISRELGDRLGEGTALGNLGLTLRKVRRFEEAIDAFTQDLAICRELSDRDGEGKALNNLGLLLRMMRQFEDAIDLHTRALDIFRELGDRHRESQALGNLGLDLLEVRRFEEAIDAFTRAVDIFRELGDRYREGGALSNLGATLGEVRRFEEAIDAFTQDLAICRELGDRHDEGTALSNLGTALRESRRFEEAIDAHTRAASIFGELDDHHREVTALEDLALDLLRARRFRVLRPWRKLTRRTRSSAGGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JFE1</accession>
    <name>A0A2M9JFE1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cupin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_43710</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000044">
        <property type="protein sequence ID" value="PJN05610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN05610">
        <property type="protein sequence ID" value="PJN05610"/>
        <property type="gene ID" value="CG723_43710"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013096">
        <property type="entry name" value="Cupin_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07883">
        <property type="entry name" value="Cupin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cupin_2" evidence="1">
        <location>
            <begin position="39"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN05610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="140" mass="15508" checksum="402AD1B0297EEC9B" modified="2018-04-25" version="1">MEFVKPQPTGKGPADWFNGDVWFDVIHAGTEPSRIRANMVRFAPGARTAWHHHAVGQTLHVVAGIALIGTRDGTVYAAHPGETVTCPPGEDHWHGATEENFMQHLALWDGTAPADDRPETTWLEHVTDTQYHATRTRSSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JFZ3</accession>
    <name>A0A2M9JFZ3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">NUDIX hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_42860</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000041">
        <property type="protein sequence ID" value="PJN05804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN05804">
        <property type="protein sequence ID" value="PJN05804"/>
        <property type="gene ID" value="CG723_42860"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020084">
        <property type="entry name" value="NUDIX_hydrolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="SSF55811"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00893">
        <property type="entry name" value="NUDIX_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="2">
        <location>
            <begin position="13"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN05804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="243" mass="25845" checksum="515DFCBD27F5BD3A" modified="2018-04-25" version="1">MCVQGYDKYAFEPFAVTVDLAVFTIRDGALRVLLVERGQDPYAGRLALPGGFVLPDESAETAAARELAEETGLSDVTGLHLEQLRTYSDPDRDPRMRVVSVAFAALVPDPPEVRGGGDAARADWLPYGTGAYGPLAFDHDRILTDAHDRVGAGIENTCLATAFCPPEFTLGELRGVYEAVWGAGLDPANFRRKVLATPGFVEPVHGAARLTGGRGKPAALYKAGPATALHPPLLRPPAEGRPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JG10</accession>
    <name>A0A2M9JG10_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ATP-dependent RNA helicase HrpA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_42570</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000040">
        <property type="protein sequence ID" value="PJN05825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN05825">
        <property type="protein sequence ID" value="PJN05825"/>
        <property type="gene ID" value="CG723_42570"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011709">
        <property type="entry name" value="DEAD-box_helicase_OB_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007502">
        <property type="entry name" value="Helicase-assoc_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024590">
        <property type="entry name" value="HrpA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010222">
        <property type="entry name" value="RNA_helicase_HrpA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11898">
        <property type="entry name" value="DUF3418"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04408">
        <property type="entry name" value="HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07717">
        <property type="entry name" value="OB_NTP_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00847">
        <property type="entry name" value="HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01967">
        <property type="entry name" value="DEAH_box_HrpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0347">Helicase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="1">
        <location>
            <begin position="89"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="2">
        <location>
            <begin position="281"/>
            <end position="450"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN05825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="1339" mass="151639" checksum="97B1CE41DE61F111" modified="2018-04-25" version="1">MSTQPAPVLGTLAQRLSELSLRDAHRLGRRLEGARRIRKPEARAAVLAEIEAEAEKAEARTAQRRGRYEALEITYPEQLPVSQKKAEIADAIRDHQVVIVAGETGSGKTTQIPKICLELGRGVRGMIGHTQPRRLAARTVAERIADEMDTPLGEAVGWKVRFTDQVSPDATFVKLMTDGILLAEIQTDRELRAYDTIIIDEAHERSLNIDFLLGYLAQLLPRRPDLKVVITSATIDPERFSRHFGDAPIVEVSGRTYPVEVRYRPLLEEDSDDADRDQITAITDAVEELQGEGKGDILVFLSGEREIRDTADALEKKKFRFTEVLPLYARLSHAEQHRVFQRPSGSLRRIVLATNVAETSLTVPGIKYVIDPGTARISRYSHRTKVQRLPIEAISQASANQRKGRCGRTSDGICIRLYSEDDFVARPEFTDAEILRTNLASVILQMTAAGLGDIEKFPFIDPPDHRNIRDGVQLLQELGALNPAEKDVRKRLTEQGRKLAQLPVDPRLARMVLEADKNGCVREVMVIAAALSIQDPRERPSDKQAQADQQHARFKDETSDFLAFLNLWRYVREQQKTLGSSAFRRMCKSEYLNFLRIREWQDIYTQLRTVAKQMGLHLEEPSAGADAPDQQVHISLLAGLLSHIGMKDVKESTDKDPKQRGGRNEYLGARNAKFAVFPGSALFKKPPRFIMSAELVETSRLWARVNAKIEPEWVEPLAEHLLKRTYSEPHWEKDQAAVMAYEKVTLYGVPLVAQRKVNYGRIDPEVSRELFIRNALVEGDWRTHHKFFSDNRRLLTEVEELEHRARRRDIVVDDETLFDFYDQRIPDHVVSGAHFDSWWKHKKQDEPELLDFERSMLIRESAEAITKDDYPDSWRQGPLKFRVTYQFEPGADADGVTVHVPLQVLNQVTSEGFDWQIPGLREDVVTELIRSLPKPVRRHYVPAPNYAKAFLERAVPSADGRQATQQEALPTTLARELQRMVGVPVTPDDFDLSRVPDHLKITFRIVDERRRTLGEDKDLEALKLRLKPKARKAISQAAAATAERSGGASVERSGLTDWTIGTLSRVFETRRAGQPVKAYPALVDDGDTVSVRLFDTEAEQQQAMWKGTRRLILRNIPVNPGKFASDKLTNPQKLALSANPHGTVQALFDDCAMASCDKLIADFGGPAWDEESYRKLYDKVRAEIVDTTVRTVGQVQQVLAAWQACERRLKSTKSPTLLANLTDVRTQLTALIRPGFVTDTGLRRLPDLVRYLVAADRRLTQMPTNVQRDTSRMEKVHEMQDEYAWLLEQMPQGRPVPQEVLDIRWMLEELRVSYFAHALGTAYPVSDKRIVKAIDAAAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JG45</accession>
    <name>A0A2M9JG45_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CG723_42445</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000040">
        <property type="protein sequence ID" value="PJN05848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN05848">
        <property type="protein sequence ID" value="PJN05848"/>
        <property type="gene ID" value="CG723_42445"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014915956" evidence="3">
        <location>
            <begin position="43"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="55"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="127"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="435"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="127"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PJN05848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="618" mass="64932" checksum="7C41E9FB5E976F2E" modified="2018-04-25" version="1">MGAEMGARAARSRALAVLRIRGRALAVALLPAAFAVVLAAGAATGHMVGDGWRTVRWLVTVLALVVLACAAGIALVVARARPAVSPTVPIAEERAPDLYRLVRDLADRLDVPAPSAIALTPDCDSWLEDRTHPAHGPPRPKDDEGRIPRDADGPGIRGGGAGRGRVPAAPVLVIGSPFLWWMRVGELRAVLAPVVAGTGPSAHPDIAAARRFVRGLDAAVAVAAAPGRGPLGRAVLGCVGWVARLLLRSCRGHAGEMERGVAAAAAERAQTVDYGVRIVAQEQVGLAYAGWDRLLTRVALPAWRMGRWPSRLDVGVVAALTELSRRDRLAEGFASRLGERPACDLLEEPGTVDEAASLLAARLFHGGPAEPGPDWAPVDWQEYPDEVVDRKWRMDAARLHRVLDALGVRSSADPASPDPEGPTLARVMEHLATATRAGDSVGPVAPVDREDPTVPAKDLTAAADTDATVSPDDDSTAPEGPEDREDTPTALLAAGLSAESAREECERPAPPVPAAGQGPDGALWDEGMLPLFPLQPPRTGRELVADHVTAMVCCAAVDTAGAAPGLDWLDGPSLLVDGERAKDLTPRVLSLVEDGDPEPLRAWLTRLGIRPEKPVRLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JGR8</accession>
    <name>A0A2M9JGR8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">GntR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CG723_41525</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000036">
        <property type="protein sequence ID" value="PJN06074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN06074">
        <property type="protein sequence ID" value="PJN06074"/>
        <property type="gene ID" value="CG723_41525"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07377">
        <property type="entry name" value="WHTH_GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.530">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011711">
        <property type="entry name" value="GntR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008920">
        <property type="entry name" value="TF_FadR/GntR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07729">
        <property type="entry name" value="FCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
        <property type="entry name" value="GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00035">
        <property type="entry name" value="HTHGNTR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00895">
        <property type="entry name" value="FCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00345">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48008">
        <property type="entry name" value="SSF48008"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50949">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH gntR-type" evidence="4">
        <location>
            <begin position="1"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PJN06074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="224" mass="24315" checksum="0AC16AA358D5EF5D" modified="2018-04-25" version="1">MTAKQDVVAQLRALIASGELTPGQKLPAEPALCDQLGASRGSLREAVRELEALGVLQARHGSGTYVSQLRPAEMMRGFSATVDLIPLDGLLELVENRRVLESHAAGQAAARATAELDTELSELLTSMERETDHTALSHLDARFHQRICDAGGNESLAALVEVFRSRGSHYDIYSIEEVRRDSDAGHRAIAAAITARDPMAAALTAGAHITHIQEWLRRFRPSPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JH90</accession>
    <name>A0A2M9JH90_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_40190</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000033">
        <property type="protein sequence ID" value="PJN06241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN06241">
        <property type="protein sequence ID" value="PJN06241"/>
        <property type="gene ID" value="CG723_40190"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.261">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003781">
        <property type="entry name" value="CoA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005811">
        <property type="entry name" value="CoA_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016102">
        <property type="entry name" value="Succinyl-CoA_synth-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02629">
        <property type="entry name" value="CoA_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00549">
        <property type="entry name" value="Ligase_CoA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52210">
        <property type="entry name" value="SSF52210"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CoA_binding" evidence="2">
        <location>
            <begin position="195"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="domain" description="Ligase_CoA" evidence="1">
        <location>
            <begin position="343"/>
            <end position="493"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00549"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN06241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="523" mass="52228" checksum="55145706D9FA8221" modified="2018-04-25" version="1">MVLRNAVHKDLYADSVALMRVAARLAEPPGIETISLVMGTPANRDVLARSGLLTTPGHDAGPNDLLVAVRGEPDAVDTALALAVDALSGPGEGPGAGPEAGADAGPPVRSLAGAPADAGLALISTPGPYAAAEALKALRLGMHAFVFSDHVPIEQEVLLKREAARRGLLVMGPDCGTAVISGIPLGFANEVRAGCVGLVGASGTGLQQVSSLLHSMGAGVSHVIGTGSRDVSAEVGGLTMRAGLDALAADPATDVIVLVSKPPASHVAQQLICHAGALGKPVVACFLGTDETSPAPARVTLAPTLFEAARSAASLAAGGALPPGEELPKLPAPARPRRLLRALYAGGTFAHEAAWLLGPVLGGITRSAPPPAPGAAPSLPDRHLVLDLGDDEFTAGRPHPMIDPTVRTEYLRAALADPRSAAVVLDVVIGHGAAPDPAAALAGALAEAPADAPPVIAFVVGTDDDPQGLTAQRRILRAAGAHVVDSSTTAARVCAELLSSSDDLVLAPAASAPAPASRIGETA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-09-29" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JHL9</accession>
    <name>A0A2M9JHL9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">(2Fe-2S)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_39455</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000031">
        <property type="protein sequence ID" value="PJN06343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN06343">
        <property type="protein sequence ID" value="PJN06343"/>
        <property type="gene ID" value="CG723_39455"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00207">
        <property type="entry name" value="fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002888">
        <property type="entry name" value="2Fe-2S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036884">
        <property type="entry name" value="2Fe-2S-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036010">
        <property type="entry name" value="2Fe-2S_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001041">
        <property type="entry name" value="2Fe-2S_ferredoxin-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006058">
        <property type="entry name" value="2Fe2S_fd_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00111">
        <property type="entry name" value="Fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01799">
        <property type="entry name" value="Fer2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47741">
        <property type="entry name" value="SSF47741"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54292">
        <property type="entry name" value="SSF54292"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00197">
        <property type="entry name" value="2FE2S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51085">
        <property type="entry name" value="2FE2S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="2Fe-2S ferredoxin-type" evidence="2">
        <location>
            <begin position="7"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN06343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="179" mass="18670" checksum="FB9E7D57CB382A2A" modified="2018-04-25" version="1">MAPSTSSVITLNINGEKYTLPVDHRTTLLDALRERLDLPGTKKGCDQGQCGACTVLLDGRRAVSCLQLAVAAEGREITTIEGVADADGLHPVQQAFLDLDGYQCGYCTPGQICSALAVIEEHAAGWPSAVTADVRPEAGVPALTADEIRERMSGNLCRCGAYVSIVNAVARAAGTEAVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JHQ4</accession>
    <name>A0A2M9JHQ4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Diguanylate phosphodiesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CG723_40345</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CB01635</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CdaR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000033">
        <property type="protein sequence ID" value="PJN06287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN06287">
        <property type="protein sequence ID" value="PJN06287"/>
        <property type="gene ID" value="CG723_40345"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2840">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041522">
        <property type="entry name" value="CdaR_GGDEF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025736">
        <property type="entry name" value="PucR_C-HTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042070">
        <property type="entry name" value="PucR_C-HTH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13185">
        <property type="entry name" value="GAF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17853">
        <property type="entry name" value="GGDEF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13556">
        <property type="entry name" value="HTH_30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00065">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GAF" evidence="3">
        <location>
            <begin position="98"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PJN06287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="647" mass="69149" checksum="2D653F3C57804301" modified="2018-04-25" version="1">MSHDRAQSPSGPAGPERPASSAEAPFLELLARGASADAYEQPVLVARAEGEGQGRIDALEQAKGLALRVRADLEGRRRREAELSALFETAHDLAGLRDLGAVLQAIVQRARSLLSTDVAYLTLNDPARGDTYMRVTEGSVAARFQQLRLGMGEGLGGLVAQTARPYVTEDYAQDIRFKHTRTIDTGVHDEGLVAILGVPLMLGPHVIGVLFAADRRARVFEREQIALLGSFAALAAAAIDTANLLSETREALGELERANEIIRDRGDVIERASDVHDRLAELVLRGGGVHDVAAAVSQVLDGTVEFADVVTAPDKPLDASRADGHAVRDGDDWVAAVAAGGELLGALVLRGHPGLDPVDQRTLERAAMVTSLLLLARRSASEAEQRVRGELLDDLLDARDRDPRLLRERAARLHADLDAAHVVLAARLETPGADAEQEAAARRRLWSAASHVAATRHGLAAARDGGTVLLLPLRTGDRASDLARRTAKHLSAAVHEQVTVGASAPVEDLTTRTDTVAAAYAEGQRCLDALRLLGRAGEGAAADDFGFLGLLLADSRDISGFVERTMGEVVTYDRRRGTDLVRTLDAYFASGMSPARTKDALHVHVNTVAQRLERIGRLLGPDWQSPARALEIQLALRLHRLAGAISG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JHU4</accession>
    <name>A0A2M9JHU4_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Carrier domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CG723_39995</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000032">
        <property type="protein sequence ID" value="PJN06327.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN06327">
        <property type="protein sequence ID" value="PJN06327"/>
        <property type="gene ID" value="CG723_39995"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004315">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017000">
        <property type="term" value="P:antibiotic biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901362">
        <property type="term" value="P:organic cyclic compound biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030639">
        <property type="term" value="P:polyketide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018201">
        <property type="entry name" value="Ketoacyl_synth_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032821">
        <property type="entry name" value="PKS_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013968">
        <property type="entry name" value="PKS_KR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16197">
        <property type="entry name" value="KAsynt_C_assoc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02801">
        <property type="entry name" value="Ketoacyl-synt_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08659">
        <property type="entry name" value="KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00825">
        <property type="entry name" value="PKS_KS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="SSF47336"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00606">
        <property type="entry name" value="B_KETOACYL_SYNTHASE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="4" id="KW-0045">Antibiotic biosynthesis</keyword>
    <keyword evidence="1 6" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Carrier" evidence="8">
        <location>
            <begin position="1897"/>
            <end position="1974"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="585"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="6">
        <location>
            <position position="1933"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PJN06327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="1974" mass="205019" checksum="158826818B122451" modified="2018-04-25" version="1">MDGMDAKEILTRVKTGALDAASAAALLRAEATPAPAAGVDGATAAALLRAAAGQATPAAPAPAPAGVPEPVAVIGYSARFPGADDADTFWQRILDGDDLVTEVPAERWRIADHYDADPAAEGKSVSKWGAFVDGADRFDADFFRMTPREAELTDPQARLFLQEAWRALEHAGQRTGALAGARVGVYAGVMMNDYQDLIERESEHTRLAQVMQGNSNSLLAARIAYHLDLKGPAVTVDTACSSSLVALHQACQSLWLGEADMMLVGGVTLYLTELPHVFMSRAGMLSPSGRCRPFDASADGIVPGEGCAVVVLKPLSRAVADGDPVHGVIRAGGLNQDGRTNGITAPSAASQARLIAGTLDRFGLDPHGVDYVECHGTGTPLGDPIEITALNQVFGPAGRPAGSVPIGSVKGNVGHTSAAAGLAGLIKAMGVVRTGQVPPSLHCTAATLNPGIPFEDGPFTVATERLTLPGTGGRPRRASVSSFGFSGTNAYVVVEQPPPAGPVTAVATDLPVLVPVSGRRPGALADRAAELARWLRSPGGADAALADLAHTLSCARDHHPHRAALLVDDREQLLDSLDRLAVGGGDERRVEGPAAPAAEARTADREARRARAALLRRVLDRAADEPGNRGHLRELARLYAEGHDVDFTRLCPPGRYRRISVPGYAFARDRHYVSARPAASAVPDTHAVPGTFDTHDTLDDLVLYAPGWQDAPLPADAPRPAQGPLLVHDTRGDLAAALGGTGLDEIDTVRATEPDAVTLVVRIGPDPDADAAAFAALRTVLSAFRTQRLTVLAVTADALRADAARALVQTLRQENPRLDGRALLVADDGAAAAPSVRAELAVPQPESGHLADVRGARRVRRVLRPAALPEEGFVPRPDGVYLVTGGMGGIGRALARRLAARPGTRVVVCGRTPWAELDPAARPPADGAGGIRYVRADVTAPEGAAELVAGILAHEGALHGVFHAAGVVRDAYLLRKTPADVAAVLAPKTAGAAALDEATAGLPLDVFALFSSVAAVSGNIGQADYAYANGALDALAERRGGLTAAGERHGRTVSVQWPLWDVPGMTIPEPVREVVEERVGMVPLPADRGLRALERLLGPGGPQVVSLFHGRADAWHRHLAELHLLPGAESAAPAGAVDTTSPAVTPDGLVELVCRTVADTLGHDPSAIGPRTSLEALGLDSVMIRTLASKLSAQVAPVGPEMLFGLRDLTELAGHLARLTPQRAPAAVTVEPSGPSVAEPPVEPSVLAAAAVTGAPHGGPALGPALSPAFGPDDAVAIVGLAGRYPGADDPEAFWENLLVGKDTVGDLPTDRWRSSGGVRAKGHFLDRVDSFDPAFFGLSAREAAFTDPQERLFLEVAWEALEDAGLAGARLDALTAPDGEPRSVGVFAGITSADYPLLGAERWAAGQRDMPSGHFWSLPNRLSYLLDLRGPSQPVDTACSSSLVALHLAVEALRRGECAAALVGGVNLYLHPSRFRMLRQSGFLAEDGLCRSFGAGGAGFGPGEGAGAVVVKPLARALADGDTVHAVIRGTAVAHGGRTNGFTAPSPWAQARVLREALRRSGVDPATVNVIEAHGTGTELGDPVELAGLQESYGRGDAAAVPCSLGSVKSAIGHGESAAGIAALTKVLLQLRHGTLAPTWHADPVNPGLDLAGTRFSLQHEAAPWPRLRDASGRELPRRAGVSSFGAGGVNAHVVVEEHLPRPVADESAPQPAGRQLVVLSAPTPAHLAATAARLSQWLPGAGAPLADVARTLRSGRAVHEHRLAVVADSAAQLASELARFAADGTAFGALRTGTAGTARAQAPETDDLVAALWRADRPEQIADLWVTGWEVDWTALDPGPGRIVSVPPSAFLRGRYWLAEDEAADAETPAEAPAETLIQALAETPADPASDPASDPRLARIVEFVGELAAGPGAEGPVDTGRTLVELGVDSIGAMNLRFEITERFGETLPLQLLSEFTVDELVARLSDLQTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JID7</accession>
    <name>A0A2M9JID7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GntR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_37870</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000027">
        <property type="protein sequence ID" value="PJN06655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN06655">
        <property type="protein sequence ID" value="PJN06655"/>
        <property type="gene ID" value="CG723_37870"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07377">
        <property type="entry name" value="WHTH_GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1410.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028978">
        <property type="entry name" value="Chorismate_lyase_/UTRA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011663">
        <property type="entry name" value="UTRA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
        <property type="entry name" value="GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07702">
        <property type="entry name" value="UTRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00035">
        <property type="entry name" value="HTHGNTR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00345">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00866">
        <property type="entry name" value="UTRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64288">
        <property type="entry name" value="SSF64288"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50949">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH gntR-type" evidence="1">
        <location>
            <begin position="15"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN06655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="249" mass="27642" checksum="735078D6B91E68FD" modified="2018-04-25" version="1">MTSFAPDSIVLNRKLPLWYQVSQSLRASILGRSPDDPLRLPTEEQLAGHYGVSVLTMRQALKELEDEGLITRHRRRGTFIEPAALRGAPVRLLGSVDAIVAQQSGMTTELLDHGTVPVPGALAEHFPGAGTVATYHRLRCDEETGEPTNHARNYIRADLADRVDLADLVRWPMTKVLRDVVGVRISRITDTVEARLADPETARLLQVPLLSPILHYTGITYDEDGRPLDVAVIHYRGDRFSFTVTLDAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JIM1</accession>
    <name>A0A2M9JIM1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_38080</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000027">
        <property type="protein sequence ID" value="PJN06718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN06718">
        <property type="protein sequence ID" value="PJN06718"/>
        <property type="gene ID" value="CG723_38080"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000572">
        <property type="entry name" value="OxRdtase_Mopterin-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036374">
        <property type="entry name" value="OxRdtase_Mopterin-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00174">
        <property type="entry name" value="Oxidored_molyb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56524">
        <property type="entry name" value="SSF56524"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Oxidored_molyb" evidence="1">
        <location>
            <begin position="52"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN06718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="221" mass="24006" checksum="8C2193494E02E691" modified="2018-04-25" version="1">MLGLGALGVAAAPTLQRGLESFLGSAADKDPTGLTDLLPNGGGFRYYSVASSVPNRSAADYRLTVDGLVDRPTTYTLPALRALPQTRLVRDVQCVTGWRVPETPFEGVRLSAILDAAGVRPSAKALRLTCFDGTYSESLTLSQARRADVLVALRMQDKPLGHTHGGPVRLYVGPMYFYKSAKWLSGITVTDRVEPGYWEERGYDVDAWVGRSNGRDDEPTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JIN2</accession>
    <name>A0A2M9JIN2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CG723_38175</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000027">
        <property type="protein sequence ID" value="PJN06703.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN06703">
        <property type="protein sequence ID" value="PJN06703"/>
        <property type="gene ID" value="CG723_38175"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097367">
        <property type="term" value="F:carbohydrate derivative binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004347">
        <property type="term" value="F:glucose-6-phosphate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001672">
        <property type="entry name" value="G6P_Isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046348">
        <property type="entry name" value="SIS_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00342">
        <property type="entry name" value="PGI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53697">
        <property type="entry name" value="SSF53697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51463">
        <property type="entry name" value="P_GLUCOSE_ISOMERASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PJN06703.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="94" mass="10697" checksum="B09855DB2BCDBE78" modified="2018-04-25" version="1" fragment="single">MPDTTPHLTVRPQWTALSDHRAKQRQVHLRDLFTTDPGRAARYTVQVGDLHVDYSKHLVTDETLRLLRELAAAADVFGLRDAMFRGEKINTTEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JJ28</accession>
    <name>A0A2M9JJ28_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Phosphoenolpyruvate synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CG723_37035</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000025">
        <property type="protein sequence ID" value="PJN06884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN06884">
        <property type="protein sequence ID" value="PJN06884"/>
        <property type="gene ID" value="CG723_37035"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008279">
        <property type="entry name" value="PEP-util_enz_mobile_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036637">
        <property type="entry name" value="Phosphohistidine_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002192">
        <property type="entry name" value="PPDK_AMP/ATP-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00391">
        <property type="entry name" value="PEP-utilizers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01326">
        <property type="entry name" value="PPDK_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52009">
        <property type="entry name" value="SSF52009"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPDK_N" evidence="3">
        <location>
            <begin position="18"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="domain" description="PEP-utilizers" evidence="2">
        <location>
            <begin position="793"/>
            <end position="864"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="412"/>
            <end position="431"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PJN06884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="870" mass="95110" checksum="93AAFED5BAA4687C" modified="2018-04-25" version="1">MSEQYVLDLQEVGETQVAVVGGKGAHLGGLSRIEGVRVPAGFCVTTDAFRRIMAEASIDERLDQLARLNPDDREAIRTLSAEIRRTVEGIAVPDDLAAAITRALGRRGEPGEQAAYAVRSSATAEDLPTASFAGQQDTYLNVMGPTAILQHVSRCWASLFTERAVTYRQRNGIDHRTVHMAVVVQQMVFPHAAGILFTADPVTGNRKVATVDAGFGLGEALVSGLVNPDVFKVRNGEVVAKAIAAKQRAVHALPAGGTQEVAIDSQRQEQPALTDAQAVRLVQLGRRIEAHFGRPQDIEWCLVDDDFQIVQSRPITTLFPVPETLDQENHVYVSVGHGQMMTDPMKPLGFSMWQLTAMVPMHEAGGRLFVDVTRRLASPASRAGLLDAMGKGDPLIRNALETVLDRDDFVPSLPDAGPGGPPAGGAPAPIETDPAVVTKLIERSQVSIAALERDVRTKTGPALFDFLLEAFEEHKRVLSDPLSIQAIMAGMEATWWLNDKLQEWLGEKNAADTLTLSAPDNITSEMGLELLDVADVIRTRPEVVAFLQGVENAGDTAFLDELAKVAGGTEARDAVEAYLDRYGMRCVGEIDITRPRWRERPTTLVPVILDNVRNFGPGAAKQRFEQGRQKAQQKEQDVLSRLRALPDGDRKADETKRMIDRVRTFIGYREYPKYGIISRYFVYKQALLEEAERLVQAGVLPEKEDIFYLTFQELHDAVRSNQVDDRLIKERKDAFRSYHALTPPRVLTSDGEAVTGAYRRDDVPDGSLIGVPVSAGTIEGRARVILDMAKADLEAGDILVTAFTDPSWSPLFVGIAGLVTEVGGLMTHGAVIAREYGLPAVVGVEQATRLIRDGQRIRVHGTDGYVEILP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JJF7</accession>
    <name>A0A2M9JJF7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CG723_36655</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000024">
        <property type="protein sequence ID" value="PJN07011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN07011">
        <property type="protein sequence ID" value="PJN07011"/>
        <property type="gene ID" value="CG723_36655"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PJN07011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="68" mass="7680" checksum="169688EE127C90A9" modified="2018-04-25" version="1">MDEQEQRSVEAVMPMNKLIMVTRLNRRRACCRSISSRCPGWRGAGVRGGARNRGPVVERALHGEDEEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JJH3</accession>
    <name>A0A2M9JJH3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_35430</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000023">
        <property type="protein sequence ID" value="PJN07031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN07031">
        <property type="protein sequence ID" value="PJN07031"/>
        <property type="gene ID" value="CG723_35430"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="38"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN07031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="65" mass="6663" checksum="8E3E0F5480AA4BE4" modified="2018-04-25" version="1">MESGPAIFAGTVFTLFGAGLLLWTGVRVMHRAPVADGVNPVASATLATLAAVASLVLGVWCFGRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JJT2</accession>
    <name>A0A2M9JJT2_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CG723_35965</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CB01635</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="NNBL01000023">
        <property type="protein sequence ID" value="PJN07123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN07123">
        <property type="protein sequence ID" value="PJN07123"/>
        <property type="gene ID" value="CG723_35965"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018391">
        <property type="entry name" value="PQQ_beta_propeller_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002372">
        <property type="entry name" value="PQQ_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_supfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13360">
        <property type="entry name" value="PQQ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00564">
        <property type="entry name" value="PQQ"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="SSF50998"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="8">
        <location>
            <begin position="22"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="273"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="463"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="713"/>
            <end position="733"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="306"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="50"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PJN07123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="770" mass="80093" checksum="C460DB7F0B7E09AD" modified="2018-04-25" version="1">MPPLRSTGPGREAEHPEYAGQYRLESCLGAGGMGVVHLATSASGLRLAIKVVHAEYAADPEFRARFRQEVNAARRVSGAFTAPVVDADPNAELPWMATLFIPGDTLAERVKRSGALASDDVRRLGAGLAEALRDIHRVGVVHRDLKPSNVLLAADGPKVIDFGISRPTDSDLRTETGKLIGSPPFMAPEQFQRPREVGPAADVFAMGAVLAHAATGRGPFDSNSPYIVAYQVVHNEPDLAGAPEDLAPLIRRCLAKEPGERPLPAEIMEALRQPSPAGTGTGTGAGAAGSGTGAFIPAQRRPSGQRYADRQPDADDGREQSTRWTRRIRRQDGPAPASTPVGQDSPASRADQPTHPRPSERATPKSPRHRRRWALTARAVLALAAAGAGIALYTAEGGGGTGSGGTAVRQAGSFKPWHKNLGGASATAPACASGPGALYCVSGGGRTTRLDPLNGHVVWASAAPRERHPSGTAAQRSAPAAPTLSGGLLHLVDDGRIRALDPRTGEERWDVDASAYEAVEHGVDTTLLIGSGGTVRALNSATGEPRWTKRVGGLGTQWIAGPGGDGDFFAVTASADGGTTSVSAIGAHGGAVRWTVRAAGSLSPFGASDEAVYLLSTDTDLLVDAVVRLDTGDRTAHRFPLTTPADQAEATESGGIAYVYGAGGSLVAVDTTATRPQDAVSWRLETSVSRPSRPVVSDRSLYLTAPDGRLLATDARTGKPLGQTRPRLGSEPGRVVGELPAPVVGERGRVYGSAPDGSVFGVDGREPGRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JJV9</accession>
    <name>A0A2M9JJV9_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Lipid II isoglutaminyl synthase (glutamine-hydrolyzing) subunit GatD</fullName>
            <ecNumber evidence="1">6.3.5.13</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Lipid II isoglutaminyl synthase glutaminase subunit</fullName>
            <ecNumber evidence="1">3.5.1.2</ecNumber>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">gatD</name>
        <name evidence="3" type="ORF">CG723_34725</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">The lipid II isoglutaminyl synthase complex catalyzes the formation of alpha-D-isoglutamine in the cell wall lipid II stem peptide. The GatD subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia. The resulting ammonia molecule is channeled to the active site of MurT.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + beta-D-GlcNAc-(1-&gt;4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate + H2O + L-glutamine = ADP + beta-D-GlcNAc-(1-&gt;4)-Mur2Ac(oyl-L-Ala-D-isoglutaminyl-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate + H(+) + L-glutamate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:57928"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:60033"/>
            <dbReference type="ChEBI" id="CHEBI:62233"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.5.13"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>H2O + L-glutamine = L-glutamate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:15889"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="EC" id="3.5.1.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Forms a heterodimer with MurT.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the CobB/CobQ family. GatD subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.13" evidence="1"/>
    <dbReference type="EC" id="3.5.1.2" evidence="1"/>
    <dbReference type="EMBL" id="NNBL01000022">
        <property type="protein sequence ID" value="PJN07153.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN07153">
        <property type="protein sequence ID" value="PJN07153"/>
        <property type="gene ID" value="CG723_34725"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140282">
        <property type="term" value="F:carbon-nitrogen ligase activity on lipid II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004359">
        <property type="term" value="F:glutaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009236">
        <property type="term" value="P:cobalamin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01750">
        <property type="entry name" value="GATase1_CobQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02213">
        <property type="entry name" value="Lipid_II_synth_GatD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033949">
        <property type="entry name" value="CobQ_GATase1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011698">
        <property type="entry name" value="GATase_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043702">
        <property type="entry name" value="Lipid_II_synth_GatD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07685">
        <property type="entry name" value="GATase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0133">Cell shape</keyword>
    <keyword evidence="1" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="1 3" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0436">Ligase</keyword>
    <keyword evidence="1" id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GATase_3" evidence="2">
        <location>
            <begin position="8"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="1">
        <location>
            <position position="94"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="195"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="129"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN07153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="242" mass="26281" checksum="DDD55375FE98CBE6" modified="2018-04-25" version="1">MSDNGLRLVWVYPDLLSTYGDQGNALVVERRARQRRLDVHRLDVRSDQPVPTSGDIYLIGGGEDRPQRLAAERLRRDGGLQRAVANGAIVFSVCAGYQILGHEFINDLGEREQGLGLLDVVSTRGEGERCVGDVLGDIDPQLGLPPLTGFENHQGITHLGPSARPFARVQIGKGNGTGDGTEGAFNDTVFGTYMHGPVLARNPLIADLLLKLALDVNALPPVDDRWYEALRNERIASAQQPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JKD5</accession>
    <name>A0A2M9JKD5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Nucleoside-diphosphate sugar epimerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_34320</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000021">
        <property type="protein sequence ID" value="PJN07330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN07330">
        <property type="protein sequence ID" value="PJN07330"/>
        <property type="gene ID" value="CG723_34320"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016040">
        <property type="entry name" value="NAD(P)-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13460">
        <property type="entry name" value="NAD_binding_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD(P)-bd_dom" evidence="1">
        <location>
            <begin position="8"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN07330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="248" mass="26557" checksum="4137B2C76FC0B85B" modified="2018-04-25" version="1">MTTILVTGGTGTLGRLVAERLRAGGHEVRVLSRHARPYAVDLREGGPGLDEAVAGVDAIVHCASTPRGGDEKAARHLIEATRRAGVPHLLYISIVGVDRVPLGYYKSKHAVEKLVEESGLGWTVLRTTQFHDLVFQGLQTLARLPVMLLPAGVADQPVEVAEVADRLVGLATGAPAGRVADMGGPEVRTAPDLARAYLRASRRRRPVVEVRLAGKAYKGMRDGGHLTPERAVGKGTFEEFLARRFPAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JKM3</accession>
    <name>A0A2M9JKM3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_33460</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000020">
        <property type="protein sequence ID" value="PJN07416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN07416">
        <property type="protein sequence ID" value="PJN07416"/>
        <property type="gene ID" value="CG723_33460"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001845">
        <property type="entry name" value="HTH_ArsR_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01022">
        <property type="entry name" value="HTH_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00778">
        <property type="entry name" value="HTHARSR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00418">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50987">
        <property type="entry name" value="HTH_ARSR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH arsR-type" evidence="1">
        <location>
            <begin position="27"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN07416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="120" mass="12869" checksum="A99A900CE8557A74" modified="2018-04-25" version="1">MHLVPAERADRRTIDGHRVCEAIAAIGEPGHVRAWADRFSLLADPRRLALLLALYRAGPLAVSDLAVATGMNDPAVSQALRLLRAAGVVEGEKEGRIVRYRVVDAATADLLEHCATDGAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JKM5</accession>
    <name>A0A2M9JKM5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Glycosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CG723_33520</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000020">
        <property type="protein sequence ID" value="PJN07425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN07425">
        <property type="protein sequence ID" value="PJN07425"/>
        <property type="gene ID" value="CG723_33520"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018641">
        <property type="entry name" value="Trfase_1_rSAM/selenodom_assoc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36529">
        <property type="entry name" value="PTHR36529"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09837">
        <property type="entry name" value="DUF2064"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PJN07425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="222" mass="22997" checksum="3B594C521EFEF7C0" modified="2018-04-25" version="1">MTAGGSPAARRHETTLLVIAKSPVPGRVKTRLTPPFTPEEAARLAEASLVDTLHAALATPARRRVLVLDGAPGAWLPPGIDVVPQCGGSLDERLAAAFAGCTGPAVLIGMDTPQVTPALLAPALGPDAWRGCDAWFGPADDGGFWALGLAEPDPELLRGVPMSTAHTGAAQRARLTDAGLRVRDLPVLRDVDTAHDAALVAADAPDGRFAAEHARLTRVVRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-09-29" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JKV9</accession>
    <name>A0A2M9JKV9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Lipid-transfer protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CG723_34045</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000020">
        <property type="protein sequence ID" value="PJN07509.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN07509">
        <property type="protein sequence ID" value="PJN07509"/>
        <property type="gene ID" value="CG723_34045"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002155">
        <property type="entry name" value="Thiolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000429">
        <property type="entry name" value="Ac-CoA_Ac_transf"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PJN07509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="347" mass="36680" checksum="F2046986C13B168C" modified="2018-04-25" version="1">MREVAIVAFAQSDHLRTTDELSEVDMVMPVLHQVLAQTGLRTSDIGFTCSGSSDYLAGRAFSFTMTLDGVGAWPPISESHVEMDGAWAMYEAWVKLLTGEVDTALVYSYGKSSPGSVRDVLTRQLDPYYVAPLWPDSVALAALQAQALIDAGETDETALAGIAARSRESATANCHAQVKGSVPQGGYEVQPLRKGDCPPVSDGAVAVILAAGDKARELCERPAWIRGMDHRIEAHSLGVRDLTDSPSSRLAAERAGAFERPVDTAELHAPFTSQEVVLRKALKLGDDVAVNPSGGALAANPVMAAGLLRIGEAAARIHRGESDRALAHATSGPCLQQNLVAVLEGDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JKX2</accession>
    <name>A0A2M9JKX2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_33875</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000020">
        <property type="protein sequence ID" value="PJN07526.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN07526">
        <property type="protein sequence ID" value="PJN07526"/>
        <property type="gene ID" value="CG723_33875"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="41"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="70"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="99"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN07526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="125" mass="12383" checksum="7AC0052ABD30DACB" modified="2018-04-25" version="1">MTALVAALTAVAGVLLVRGVLGVAVFAPERDGAMGDASTGMLAGGAAVAALVATLLLHLLCLGTPQPGRFFSWIVTLATLVVVLLTFTTSVAMVTKVGTAAVCLAVGLTIGVLLTPVARGAVRGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JKX4</accession>
    <name>A0A2M9JKX4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_33845</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000020">
        <property type="protein sequence ID" value="PJN07524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN07524">
        <property type="protein sequence ID" value="PJN07524"/>
        <property type="gene ID" value="CG723_33845"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="68"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="105"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="139"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="180"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN07524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="246" mass="26617" checksum="3BFA94E408C0266F" modified="2018-04-25" version="1">MRQKVGPIHTARRVFKPSRSGIVDDALVARVQKIRTLVGLGAVVWVSMSYKLANSVSDVVSDRGDQAWLSVLMLSVTFPVAVGVLLALAAPSARRELLRRAAKSFGAMVSIVAAVGVFPAIMLTGFMEGRFATNPVMAVVTYSVLVLTFVWVVPFIFWGIGLALVYVFRTADIHETVPPLLAMTLVWEMTLVDLFTGAYAGVPGPLRVLLMLGAPASVTAVGLWELHRLRAHFGIGVRDMLMRQAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JKY1</accession>
    <name>A0A2M9JKY1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">IclR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CG723_33795</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000020">
        <property type="protein sequence ID" value="PJN07523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN07523">
        <property type="protein sequence ID" value="PJN07523"/>
        <property type="gene ID" value="CG723_33795"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014757">
        <property type="entry name" value="Tscrpt_reg_IclR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005471">
        <property type="entry name" value="Tscrpt_reg_IclR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09339">
        <property type="entry name" value="HTH_IclR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01614">
        <property type="entry name" value="IclR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00346">
        <property type="entry name" value="HTH_ICLR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51077">
        <property type="entry name" value="HTH_ICLR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51078">
        <property type="entry name" value="ICLR_ED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH iclR-type" evidence="3">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="domain" description="IclR-ED" evidence="4">
        <location>
            <begin position="60"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PJN07523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="240" mass="26108" checksum="560CAAAFC4223471" modified="2018-04-25" version="1">MLDKSAQILETFLPDGGPYRLSELVERTGLTKPTAHRLTADLVRLGWLERSGAHYQLGAKLFEFGSLVPRRRDLRETALPFLQDLFEATHETVHLGVREGLEVVYLERIHGHDAPWLPSRIGGGLPLTCTGVGKALLAFSGAELLDEVLARPLPSLTPYSITDPERLRTSLEKVQVAGLAYEEREAAQDVSCIAAPVFAGGTAVAALSVAVPRTRFRPAQLAPAVRTSALGLSRVLRRGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JLA1</accession>
    <name>A0A2M9JLA1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_33400</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000019">
        <property type="protein sequence ID" value="PJN07656.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN07656">
        <property type="protein sequence ID" value="PJN07656"/>
        <property type="gene ID" value="CG723_33400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002577">
        <property type="entry name" value="HTH_HxlR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01638">
        <property type="entry name" value="HxlR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51118">
        <property type="entry name" value="HTH_HXLR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH hxlR-type" evidence="1">
        <location>
            <begin position="23"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN07656.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="125" mass="13403" checksum="AF6D3E3E3D60FAD7" modified="2018-04-25" version="1">MAGNGEHESGSVREAGIHNPDACKRVDGGITRVFGLLGKRWTGLVVSVLLQHPVHFADLRRAIPGISERMLSDRLTELGAAGLVVREVDEGPPLRVAYRLTEAGAALEPALKELGLWAEAYLPEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JLI2</accession>
    <name>A0A2M9JLI2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GNAT family N-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_32115</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000018">
        <property type="protein sequence ID" value="PJN07718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN07718">
        <property type="protein sequence ID" value="PJN07718"/>
        <property type="gene ID" value="CG723_32115"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13302">
        <property type="entry name" value="Acetyltransf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="18"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN07718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="215" mass="23900" checksum="06A42C9E60FC76D3" modified="2018-04-25" version="1">MTTGTRGFPDISISTDRLVLRALEEDDAPALAEMMNDEMVAAWTSVPQPFTEDQARTWITQYAPTERIAGRGLDLAVTEFLTQRLVGIVQLGKTNWHVSSTELSYIIAPWARGEGYASEAALATARWLFREQGLERLELRTAADNTASQQVAQKIGCISEGVLRNACIARTRTEDGGWEDLRTDFIVWSLLPEDLDGVSDEFAETSGYTSFSDWN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JLQ8</accession>
    <name>A0A2M9JLQ8_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Proteasome subunit alpha</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">20S proteasome alpha subunit</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="2">Proteasome core protein PrcA</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2 5" type="primary">prcA</name>
        <name evidence="5" type="ORF">CG723_32585</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CB01635</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation.</text>
    </comment>
    <comment type="activity regulation">
        <text evidence="2">The formation of the proteasomal ATPase ARC-20S proteasome complex, likely via the docking of the C-termini of ARC into the intersubunit pockets in the alpha-rings, may trigger opening of the gate for substrate entry. Interconversion between the open-gate and close-gate conformations leads to a dynamic regulation of the 20S proteasome proteolysis activity.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein degradation; proteasomal Pup-dependent pathway.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">The 20S proteasome core is composed of 14 alpha and 14 beta subunits that assemble into four stacked heptameric rings, resulting in a barrel-shaped structure. The two inner rings, each composed of seven catalytic beta subunits, are sandwiched by two outer rings, each composed of seven alpha subunits. The catalytic chamber with the active sites is on the inside of the barrel. Has a gated structure, the ends of the cylinder being occluded by the N-termini of the alpha-subunits. Is capped by the proteasome-associated ATPase, ARC.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 3">Belongs to the peptidase T1A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000018">
        <property type="protein sequence ID" value="PJN07803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN07803">
        <property type="protein sequence ID" value="PJN07803"/>
        <property type="gene ID" value="CG723_32585"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00997"/>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019773">
        <property type="term" value="C:proteasome core complex, alpha-subunit complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004298">
        <property type="term" value="F:threonine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019941">
        <property type="term" value="P:modification-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010498">
        <property type="term" value="P:proteasomal protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00289_B">
        <property type="entry name" value="Proteasome_A_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023332">
        <property type="entry name" value="Proteasome_alpha-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022296">
        <property type="entry name" value="Proteasome_asu_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11599:SF69">
        <property type="entry name" value="PTHR11599:SF69"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="SSF56235"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03691">
        <property type="entry name" value="20S_bact_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51475">
        <property type="entry name" value="PROTEASOME_ALPHA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 2 3" id="KW-0647">Proteasome</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="231"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PJN07803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="252" mass="27691" checksum="ECE6FDED703E22F3" modified="2018-04-25" version="1">MSTPFYVSPQQAMADRAEYARKGIARGRSLVVLQYADGIVFVGENPSRALHKFSEIYDRIGFAAAGKYNEYENLRIGGVRYADLRGYTYDRDDVTARGLANVYAQTLGTIFSSSAEKPYEVELVVAEVGSEPEGDQIYRLPHDGSIVDEHGSVAVGGNAEQISTYLDQRHRDGMTLAEALKLAVQALSRDTNGSEREIPAERLEVAVLDRTRPQQRKFKRIVGPQLSRLLEAGAATSAEPVESGDAESDDEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JLQ9</accession>
    <name>A0A2M9JLQ9_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Peptidyl-prolyl cis-trans isomerase</fullName>
            <ecNumber evidence="4">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CG723_32560</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CB01635</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 3 4">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the FKBP-type PPIase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="4"/>
    <dbReference type="EMBL" id="NNBL01000018">
        <property type="protein sequence ID" value="PJN07798.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN07798">
        <property type="protein sequence ID" value="PJN07798"/>
        <property type="gene ID" value="CG723_32560"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061077">
        <property type="term" value="P:chaperone-mediated protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000413">
        <property type="term" value="P:protein peptidyl-prolyl isomerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044609">
        <property type="entry name" value="FKBP2/11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046357">
        <property type="entry name" value="PPIase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001179">
        <property type="entry name" value="PPIase_FKBP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45779">
        <property type="entry name" value="PTHR45779"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00254">
        <property type="entry name" value="FKBP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50059">
        <property type="entry name" value="FKBP_PPIASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4 6" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3 4" id="KW-0697">Rotamase</keyword>
    <feature type="domain" description="PPIase FKBP-type" evidence="5">
        <location>
            <begin position="35"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PJN07798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="124" mass="13199" checksum="1B9C88AEC904831A" modified="2018-04-25" version="1">MSIEKPEIDFPEGQPPADLEIKEIWEGDGAVAKAGDYVKVHYVGVAFSTGEEFDASWNRGNPLEFQLGAGQVITGWDKGIQGMKVGGRRRLTIPAHLAYGERGAGGGVIAPGETLIFVCDLVAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JLY4</accession>
    <name>A0A2M9JLY4_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF126 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_31215</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000017">
        <property type="protein sequence ID" value="PJN07869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN07869">
        <property type="protein sequence ID" value="PJN07869"/>
        <property type="gene ID" value="CG723_31215"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd01356">
        <property type="entry name" value="AcnX_swivel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012016">
        <property type="entry name" value="AcnX_sub2_put"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002840">
        <property type="entry name" value="AcnX_swivel_put"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01989">
        <property type="entry name" value="DUF126"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004966">
        <property type="entry name" value="UCP004966"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF126" evidence="1">
        <location>
            <begin position="33"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN07869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="151" mass="16027" checksum="F189E0DD3EAD4433" modified="2018-04-25" version="1">MTSVAEPRRLVLRGRGIVPGRVEGEALVSHETISGWGGIDPATGTIVERRHELYGVCFTGKVLVFPGAKGSSGWSGFFQSTRLMGTAPLAMVFTNLTTKAALGAIVTRVPTVTELDDDPVARIATGDRVEVDADNGLVVVHGPRPRADHPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JMH1</accession>
    <name>A0A2M9JMH1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Iron ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CG723_30785</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CB01635</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000016">
        <property type="protein sequence ID" value="PJN08069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08069">
        <property type="protein sequence ID" value="PJN08069"/>
        <property type="gene ID" value="CG723_30785"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037294">
        <property type="entry name" value="ABC_BtuC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000522">
        <property type="entry name" value="ABC_transptr_permease_BtuC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30472">
        <property type="entry name" value="PTHR30472"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01032">
        <property type="entry name" value="FecCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81345">
        <property type="entry name" value="SSF81345"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="65"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="121"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="152"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="196"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="238"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="281"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="312"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PJN08069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="337" mass="33565" checksum="2AF675DA802B7CE8" modified="2018-04-25" version="1">MLGSAPAVRRLAWPVVALTVTFAVVALSLAVGSRPVPLSTVVDALVHGANGPDALVVRSLRVPRTGIGLAAGAGLGLAGAALQAVTRNPLADPGILGLSQGAAAGVVLALATGRADGFSGYVWWAFGGAVVAAFLVYVIASRGRGGASPVKLALAGTAFSAMIAGGTTVALTSSSATLDQFRFWQVGAIDGRDAGTIVQMLPFLGAGALLVLCSARGLDGLALGDETARALGHRVHRIRIAAALGATLLTAAAVAASGPIAFVGLAVPHLARRLVGGGHRWTLPLSALLGACLLVGADVAGRVVRPPGEVPAGVMTALVGVPVLIWLVRGRRTVGEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JNV3</accession>
    <name>A0A2M9JNV3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Isochorismatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_27570</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000013">
        <property type="protein sequence ID" value="PJN08540.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08540">
        <property type="protein sequence ID" value="PJN08540"/>
        <property type="gene ID" value="CG723_27570"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.850">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000868">
        <property type="entry name" value="Isochorismatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036380">
        <property type="entry name" value="Isochorismatase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00857">
        <property type="entry name" value="Isochorismatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52499">
        <property type="entry name" value="SSF52499"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Isochorismatase" evidence="1">
        <location>
            <begin position="5"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN08540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="195" mass="21672" checksum="EF9C131D3F9BD7E7" modified="2018-04-25" version="1">MSKVAVLTNDLQYDLVNKNQERIDAVAEATPSFSGFLKDMRQRGHHVLHLQLINKADDPVAERYEGGRLPAQKGTQGAEILPVFLDDTDILVEKNKDSGFYETDLHERLQALGVETVIVTGMQGQICVQTTAADAFFRGYNVWVPSDCVVSAQEHDKVRALDWLDGYCATVAPSDEIVRVLDADGDLPRKVFRTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JP18</accession>
    <name>A0A2M9JP18_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Peptide synthetase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CG723_27575</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CB01635</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Antibiotic biosynthesis.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000013">
        <property type="protein sequence ID" value="PJN08622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08622">
        <property type="protein sequence ID" value="PJN08622"/>
        <property type="gene ID" value="CG723_27575"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00906">
        <property type="reaction ID" value="UER00896"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017000">
        <property type="term" value="P:antibiotic biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010071">
        <property type="entry name" value="AA_adenyl_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020459">
        <property type="entry name" value="AMP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00154">
        <property type="entry name" value="AMPBINDING"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="SSF47336"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01733">
        <property type="entry name" value="AA-adenyl-dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0045">Antibiotic biosynthesis</keyword>
    <keyword evidence="2 5" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="6">
        <location>
            <begin position="804"/>
            <end position="877"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="5">
        <location>
            <position position="838"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PJN08622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="884" mass="94140" checksum="036286E0BDA90B5D" modified="2018-04-25" version="1">MRLWAEPVPAPSDSPAALRRRTRELHGRHGGDGVHGVRLTLLEYADGVRDLVAVTGPGDDGPDLLDRAALAALGPALPLARSGSPSDSDPGCREVPVPGLGAGGAMATAADLAAALLLIAARTRAQDEPVLDVAVHTTDGVRRVSLCVAVSDEDQPVSAYRAWVREQAERPGAQDGGGGPRLALDVDLRPRAVPAVRRLPALDARHPVTVRVTASDADGTPQVHCWTLPGTPADQLPTDFEQQLALVAHQLLCGDQNLPLADIALHEPAERARILDLGRTPRAADSGPRRIDQLVRDRAEQTPDAVALRDPQGEHTWTYRELVDRSDRFAAALRGLGVRPGDRVGVCLDRSAQLVSVLLAVMTAGAAYVPLDPTYPADRLAYTADDAGLSLVVVEDGGKDDGNAFADHATVTLPRLRELAAGQGAWEEPGTVGPDDPAYIIYTSGSTGRPKGVVVPHRNVGRLLDATADDFRLGPQDVWTWFHSAAFDFSVWEIWGALGTGGRLVVVPYWTCRSPEDFRALLLDERVTVLNQTPSAFSRLLPLERTAPTPLALRLVVFGGEPLDARALLPWFDTHPESACRMVNMFGITETTVHVTAQTVTRADALASSQSVGRALPGWSVRVLDARGRLVQPGCVGEIAVGGDGLALEYLGRPELTAERFVPDPDGEGRLYLSGDKGRQLPDGRLEHLGRLDSQVKLRGHRIELDEIRSVLLTHPSVRAAAVVLTRPTDANGEDATLDAYAVLDGADAREVRRHAARLLPEYMVPATVTPLAELPLTVNGKVDVAALPVPRAAGGELPCVADESAQGTLAAVLAAWHTAFGEQVAGGDDFFELGGNSLRALRVVHLLRDAGVRVDVRDVYRLRTPSAMAEAASTAPAEAARTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JPE8</accession>
    <name>A0A2M9JPE8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Short-chain dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_27105</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000012">
        <property type="protein sequence ID" value="PJN08752.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08752">
        <property type="protein sequence ID" value="PJN08752"/>
        <property type="gene ID" value="CG723_27105"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN08752.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="291" mass="31287" checksum="BF8728D1FE6DB379" modified="2018-04-25" version="1">MSRVSLEGQVAVVTGAARGVGELLARKLAARGAKIALVGLEPDELKAVSERLDTDSDFWHADVTDHVAMAQVAEEVKQRFGKVDIVVANAGVANGGPFLDSDPVAWRRVIEVNLIGSAVTARAFLPVLMESRGYLLQIASLAAITPAPMMTAYCASKSGVEAYAHSLRAEVGYKGVRVGVGYLSWTDTDMVRGADQDDVMRELRQRLPWPSNKTYPLGPAVDRIVAGIERRSSHVYAQWWLRGMQGIRGYLPGVIGAVGQREMRRFEPRLKSVSTGLVGAGGAADESVRGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JPG9</accession>
    <name>A0A2M9JPG9_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ribosomal RNA small subunit methyltransferase A</fullName>
            <ecNumber evidence="6">2.1.1.182</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">16S rRNA dimethyladenosine transferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">16S rRNA dimethylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">S-adenosylmethionine-6-N', N'-adenosyl(rRNA) dimethyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">rsmA</name>
        <name evidence="6" type="synonym">ksgA</name>
        <name evidence="9" type="ORF">CG723_27205</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CB01635</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>adenosine(1518)/adenosine(1519) in 16S rRNA + 4 S-adenosyl-L-methionine = 4 H(+) + N(6)-dimethyladenosine(1518)/N(6)-dimethyladenosine(1519) in 16S rRNA + 4 S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:19609"/>
            <dbReference type="Rhea" id="RHEA-COMP:10232"/>
            <dbReference type="Rhea" id="RHEA-COMP:10233"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74411"/>
            <dbReference type="ChEBI" id="CHEBI:74493"/>
            <dbReference type="EC" id="2.1.1.182"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family. RsmA subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.182" evidence="6"/>
    <dbReference type="EMBL" id="NNBL01000012">
        <property type="protein sequence ID" value="PJN08769.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08769">
        <property type="protein sequence ID" value="PJN08769"/>
        <property type="gene ID" value="CG723_27205"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052908">
        <property type="term" value="F:16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00607">
        <property type="entry name" value="16SrRNA_methyltr_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001737">
        <property type="entry name" value="KsgA/Erm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023165">
        <property type="entry name" value="rRNA_Ade_diMease-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020596">
        <property type="entry name" value="rRNA_Ade_Mease_Trfase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020598">
        <property type="entry name" value="rRNA_Ade_methylase_Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011530">
        <property type="entry name" value="rRNA_adenine_dimethylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11727">
        <property type="entry name" value="PTHR11727"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00398">
        <property type="entry name" value="RrnaAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00650">
        <property type="entry name" value="rADc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00755">
        <property type="entry name" value="ksgA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01131">
        <property type="entry name" value="RRNA_A_DIMETH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51689">
        <property type="entry name" value="SAM_RNA_A_N6_MT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 6 7" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="1 6" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="4 6 7" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3 6 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="rADc" evidence="8">
        <location>
            <begin position="41"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6 7">
        <location>
            <position position="34"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6 7">
        <location>
            <position position="36"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6 7">
        <location>
            <position position="61"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6 7">
        <location>
            <position position="82"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6 7">
        <location>
            <position position="112"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6 7">
        <location>
            <position position="130"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00607"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00650"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PJN08769.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="287" mass="30081" checksum="BC4E487CBDE2C0EE" modified="2018-04-25" version="1">MSTTDPQGPLLGPADIRELAAALGVRPTKQRGQNFVIDANTVRRIVRTAQVTPEDNVVEVGPGLGSLTLALLEAAAHVTAVEIDDVLAAALPATIEARLPQKKDAFALVHSDAMQVRELPGPAPTALVANLPYNVAVPVLLHMLDTFPTIERTLVMVQAEVADRLAAAPGSKVYGVPSVKANWYADVKRAGSIGRNVFWPAPNVDSGLVALVKRAEPVATTASKREVFAVVDAAFAQRRKTLRAALSGWAGSAAAAEAALVAAGVSPQARGEAITVEEFARIAENKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JPM3</accession>
    <name>A0A2M9JPM3_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 4">UTP--glucose-1-phosphate uridylyltransferase</fullName>
            <ecNumber evidence="3 4">2.7.7.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">UDP-glucose pyrophosphorylase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">galU</name>
        <name evidence="6" type="ORF">CG723_27040</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CB01635</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 4">
            <text>alpha-D-glucose 1-phosphate + H(+) + UTP = diphosphate + UDP-alpha-D-glucose</text>
            <dbReference type="Rhea" id="RHEA:19889"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
            <dbReference type="ChEBI" id="CHEBI:58601"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="EC" id="2.7.7.9"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the UDPGP type 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.9" evidence="3 4"/>
    <dbReference type="EMBL" id="NNBL01000012">
        <property type="protein sequence ID" value="PJN08816.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08816">
        <property type="protein sequence ID" value="PJN08816"/>
        <property type="gene ID" value="CG723_27040"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003983">
        <property type="term" value="F:UTP:glucose-1-phosphate uridylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006011">
        <property type="term" value="P:UDP-glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02541">
        <property type="entry name" value="UGPase_prokaryotic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005771">
        <property type="entry name" value="GalU_uridylyltTrfase_bac/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005835">
        <property type="entry name" value="NTP_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43197">
        <property type="entry name" value="PTHR43197"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00483">
        <property type="entry name" value="NTP_transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01099">
        <property type="entry name" value="galU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="NTP_transferase" evidence="5">
        <location>
            <begin position="10"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU361259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PJN08816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="300" mass="32787" checksum="B97025CB08063AF4" modified="2018-04-25" version="1">MTESHPRISKAVIPAAGLGTRFLPATKATPKEMLPVVDKPAIQYVVEEAAAAGLDDVLMITGRNKRPLEDHFDRNYELESALQKKGDAGRLAKVQESSDLATMHYVRQGDPRGLGHAVLCAAPHVGQEPFAVLLGDDLIDPRDPLLARMVEVQEQRGGSVIALMEVEPSQIHLYGCAAVEATVDSDVVKITGLVEKPDPADAPSNYAIIGRYVLDPAIFDILRRTEPGRGGEIQLTDALQQLADDEKAGGPVHGVVFKGRRYDTGDRGDYLRAIVRLACEREDLGPDFRTWLRSYVTEEM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JPP1</accession>
    <name>A0A2M9JPP1_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Acetate kinase</fullName>
            <ecNumber evidence="6">2.7.2.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Acetokinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">ackA</name>
        <name evidence="8" type="ORF">CG723_25400</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CB01635</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>acetate + ATP = acetyl phosphate + ADP</text>
            <dbReference type="Rhea" id="RHEA:11352"/>
            <dbReference type="ChEBI" id="CHEBI:22191"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.2.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="6">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="6">Mg(2+). Can also accept Mn(2+).</text>
    </comment>
    <comment type="pathway">
        <text evidence="6">Metabolic intermediate biosynthesis; acetyl-CoA biosynthesis; acetyl-CoA from acetate: step 1/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6 7">Belongs to the acetokinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.2.1" evidence="6"/>
    <dbReference type="EMBL" id="NNBL01000011">
        <property type="protein sequence ID" value="PJN08839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08839">
        <property type="protein sequence ID" value="PJN08839"/>
        <property type="gene ID" value="CG723_25400"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00340">
        <property type="reaction ID" value="UER00458"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008776">
        <property type="term" value="F:acetate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006085">
        <property type="term" value="P:acetyl-CoA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006082">
        <property type="term" value="P:organic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00020">
        <property type="entry name" value="Acetate_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004372">
        <property type="entry name" value="Ac/propionate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000890">
        <property type="entry name" value="Aliphatic_acid_kin_short-chain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023865">
        <property type="entry name" value="Aliphatic_acid_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21060">
        <property type="entry name" value="PTHR21060"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00871">
        <property type="entry name" value="Acetate_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000722">
        <property type="entry name" value="Acetate_prop_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00471">
        <property type="entry name" value="ACETATEKNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00016">
        <property type="entry name" value="ackA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01075">
        <property type="entry name" value="ACETATE_KINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01076">
        <property type="entry name" value="ACETATE_KINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 6 7" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6 7" id="KW-0808">Transferase</keyword>
    <feature type="active site" description="Proton donor/acceptor" evidence="6">
        <location>
            <position position="154"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="12"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="19"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="97"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="214"/>
            <end position="218"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="288"/>
            <end position="290"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="336"/>
            <end position="340"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="390"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="6">
        <location>
            <position position="186"/>
        </location>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="6">
        <location>
            <position position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PJN08839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="410" mass="43856" checksum="459966B7FBD95FEB" modified="2018-04-25" version="1">MTATPSRVLVLNSGSSSLKYQLLDMESGARLAVGLVERIGEETSRLKHTPLTGDVGAAREVNGPIADHDAALKAVAAELARDGMGLDSPELAAIGHRVVHGGMFFTEPTVIDDAVLAEIERLIPVAPLHNPANLTGIRTAMALRPDLPQVAVFDTAFHTTMPESAARYAIDVKTADEHRIRRYGFHGTSHAYVSRKAAELLGKDTEEVNLIVLHLGNGASASAVRGGLCVDTSMGLTPLEGLVMGTRSGDVDPAVIFHLMRVGNMSADEIDVLLNKKSGLVGLCGDNDMREIRRRIDEGDEEARLAFDIYVHRLKKYIGAYYAVLGRVDAVVFTAGVGENAAPVREAAVAGLEELGLAVDGELNSVRSDEPRLISPEYARVAVAVVPTDEELEIAQQTYALVHDSASRND</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-05-25" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JPQ8</accession>
    <name>A0A2M9JPQ8_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Thioredoxin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">trxA</name>
        <name evidence="6" type="ORF">CG723_25315</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CB01635</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the thioredoxin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000011">
        <property type="protein sequence ID" value="PJN08825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08825">
        <property type="protein sequence ID" value="PJN08825"/>
        <property type="gene ID" value="CG723_25315"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015035">
        <property type="term" value="F:protein-disulfide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005746">
        <property type="entry name" value="Thioredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017937">
        <property type="entry name" value="Thioredoxin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000077">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01068">
        <property type="entry name" value="thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00194">
        <property type="entry name" value="THIOREDOXIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2 4" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="5">
        <location>
            <begin position="1"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="disulfide bond" description="Redox-active" evidence="4">
        <location>
            <begin position="33"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR000077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000077-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PJN08825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="108" mass="12065" checksum="10E0371DBEFAB8AF" modified="2018-04-25" version="1">MSTDLRDVTDADFDTEVLGAGRPVLVEFTAEWCGPCRQLAPVLRSIADEERERLDVVVIDVDHNPGTAVRYGVLSMPTLMVFKDGEPVWTRVGARPKRRLLEELAEVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JPW0</accession>
    <name>A0A2M9JPW0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">TetR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_25820</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000011">
        <property type="protein sequence ID" value="PJN08908.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08908">
        <property type="protein sequence ID" value="PJN08908"/>
        <property type="gene ID" value="CG723_25820"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="9"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="32"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN08908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="206" mass="21510" checksum="9EFA5580FEE25F11" modified="2018-04-25" version="1">MSPRGVAIPDVRERLFDAAERILAREGPSGLTSRAITTEAGCAKGLLHRHFAGLDELVAELVLARFAHTARLAEDLPARAGESTVAANLKTVGYALLTSLNPTTAGLAVSNPAASLRIREALEAGAPGFDAIQQSIAAYLDAEVERGRLSPATDTTATALALVGTVHHLLMTTWGDAARDPGEQTERLVTMLLGPTTGGSISHGER</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JQG9</accession>
    <name>A0A2M9JQG9_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7 8">2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase</fullName>
            <shortName evidence="7">MECDP-synthase</shortName>
            <shortName evidence="7">MECPP-synthase</shortName>
            <shortName evidence="7">MECPS</shortName>
            <ecNumber evidence="3 7 8">4.6.1.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">ispF</name>
        <name evidence="10" type="ORF">CG723_24715</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CB01635</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4-diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7 8">
            <text>4-CDP-2-C-methyl-D-erythritol 2-phosphate = 2-C-methyl-D-erythritol 2,4-cyclic diphosphate + CMP</text>
            <dbReference type="Rhea" id="RHEA:23864"/>
            <dbReference type="ChEBI" id="CHEBI:57919"/>
            <dbReference type="ChEBI" id="CHEBI:58483"/>
            <dbReference type="ChEBI" id="CHEBI:60377"/>
            <dbReference type="EC" id="4.6.1.12"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
        <text evidence="7">Binds 1 divalent metal cation per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 7">Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via DXP pathway; isopentenyl diphosphate from 1-deoxy-D-xylulose 5-phosphate: step 4/6.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homotrimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7 8">Belongs to the IspF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.6.1.12" evidence="3 7 8"/>
    <dbReference type="EMBL" id="NNBL01000010">
        <property type="protein sequence ID" value="PJN09120.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN09120">
        <property type="protein sequence ID" value="PJN09120"/>
        <property type="gene ID" value="CG723_24715"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00056">
        <property type="reaction ID" value="UER00095"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008685">
        <property type="term" value="F:2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019288">
        <property type="term" value="P:isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016114">
        <property type="term" value="P:terpenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00554">
        <property type="entry name" value="MECDP_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00107">
        <property type="entry name" value="IspF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003526">
        <property type="entry name" value="MECDP_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020555">
        <property type="entry name" value="MECDP_synthase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036571">
        <property type="entry name" value="MECDP_synthase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43181">
        <property type="entry name" value="PTHR43181"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02542">
        <property type="entry name" value="YgbB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69765">
        <property type="entry name" value="SSF69765"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00151">
        <property type="entry name" value="ispF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01350">
        <property type="entry name" value="ISPF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7 8" id="KW-0414">Isoprene biosynthesis</keyword>
    <keyword evidence="6 7 8" id="KW-0456">Lyase</keyword>
    <keyword evidence="4 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YgbB" evidence="9">
        <location>
            <begin position="11"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="4-CDP-2-C-methyl-D-erythritol 2-phosphate binding" evidence="7">
        <location>
            <begin position="16"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="region of interest" description="4-CDP-2-C-methyl-D-erythritol 2-phosphate binding" evidence="7">
        <location>
            <begin position="43"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="4-CDP-2-C-methyl-D-erythritol 2-phosphate binding" evidence="7">
        <location>
            <begin position="65"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="16"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="18"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="51"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="145"/>
        </location>
        <ligand>
            <name>4-CDP-2-C-methyl-D-erythritol 2-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:57919"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="148"/>
        </location>
        <ligand>
            <name>4-CDP-2-C-methyl-D-erythritol 2-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:57919"/>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="7">
        <location>
            <position position="43"/>
        </location>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="7">
        <location>
            <position position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004709"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012579"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PJN09120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="164" mass="16509" checksum="C0A55794B0E4E588" modified="2018-04-25" version="1">MASEMPVIPLVGIGTDIHAFEEGRELWCAGLKWEGEGPGLAGHSDADVVAHAACNALFSAAGLGDLGAHFGTGRPEWSGASGLTLLTEAARIVREAGFTIGNVAVQVIGPRPKIGKRREEAQKVLSDAAGAPVSVSGATTDGLGFPGRGDGLAAIATALVVRTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JQK1</accession>
    <name>A0A2M9JQK1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CG723_24870</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000010">
        <property type="protein sequence ID" value="PJN09148.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN09148">
        <property type="protein sequence ID" value="PJN09148"/>
        <property type="gene ID" value="CG723_24870"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PJN09148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="169" mass="19901" checksum="D5F229D3EB971BD5" modified="2018-04-25" version="1">MLDIGYALSRRFPDPIQLDYRRADVRTLRHDLFCGDVYLADTKADRELSTAWGWVPVLDFAWALCDIVEQLDRDPRGSRASRPQYAELDFTESTDRMLFERRFGWVDIEADWMEADEPPLTFSHTALRREARDFLHDLIADLTDMHEDLADNPAIWDLQARFPRIPDER</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JQL7</accession>
    <name>A0A2M9JQL7_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DUF11 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CG723_24955</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000010">
        <property type="protein sequence ID" value="PJN09162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN09162">
        <property type="protein sequence ID" value="PJN09162"/>
        <property type="gene ID" value="CG723_24955"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001434">
        <property type="entry name" value="DUF11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01345">
        <property type="entry name" value="DUF11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01451">
        <property type="entry name" value="B_ant_repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014644126" description="DUF11 domain-containing protein" evidence="3">
        <location>
            <begin position="42"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="677"/>
            <end position="697"/>
        </location>
    </feature>
    <feature type="domain" description="DUF11" evidence="4">
        <location>
            <begin position="388"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="499"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="644"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="513"/>
            <end position="527"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PJN09162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="702" mass="72471" checksum="188C78F55B430B09" modified="2018-04-25" version="1">MWLRQVSGGRRLRAAATRTAGALVATATALTALGAATPASADVVTPFTKRYDEALYGDFVTIGNTVMGCPAAPADLAARCAVAAGGRGSDNNNAFVMRRVNTAGTTAGYGSSTGRVTIPPGAKVAYARLFYGGNDGTYKGPSGAELARCDISGADVEPSPSAPLAALPVVAVNGRAAARVSTEDLVRDPAATDGPHYYTGEADVTSLFAGVTGTGAPVPVAVGGIWAPNGKGCAAGWSMTVVYKYDAPNSMYAPGRRNVYVYGGHVLQRPVSPATTIGVNGFHRAGDGKVRAGVTAYESDWNMPGDRFLVDGKNVTEAHTGNTNNFFISQDRGAVSPKTVNNLSIDAKEFELPDETVPPGATSTELTFTTKGDTYVPSALALSVPVPDLEVTRTASPKAVRPGDTITYTLKAKNISSLDYPNAEFSDDLTGNLDDATYNGDVRTDLGHVSYTAPRIGYTGYIPAGKTATITYSVKVHDPVRGDGKLPGGVEVQSPLSNCGAGSTDPSCGTAPEIEKPQPPAPPALRITNVPERPVVPPCEETGNTITIADFSARNRTGAAVEWPVTAGSAPVASTGTITKRGSVYVWKGDVATHGKVVISQRVKASCTTGGTTVITVTSDVPRTNCPKARRGEDDPCTSVITARRQQGRPGPPGESHGPHRPVDGSELATTGGSHTLLYGGLAAALWGLGVLAVAAARSRRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JQT3</accession>
    <name>A0A2M9JQT3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_24440</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000010">
        <property type="protein sequence ID" value="PJN09233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN09233">
        <property type="protein sequence ID" value="PJN09233"/>
        <property type="gene ID" value="CG723_24440"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="38"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN09233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="281" mass="29884" checksum="B19A46A54C4719E8" modified="2018-04-25" version="1">MPTDASLPLPLPVPSAEPAPAPAAPEQAPKDRRVLRAVLRWTSAVVVFGALAGAAAYGVTEQQRTRLPGLATASDGRWTYPELVRPPLPEGSPAPFAEANTAQAHYADPRALVLKAPEGARPDPGVKTDDGWVPKSVLLAQFMREEREELGQDLTDAGLRHIAGRGWIMPDGTTSRVFLLHFGTGAAAQEFSDGLVGSFTPVRQLAGTADAALDESYPDDAHVKNVTEYVYDEARPRGAEHVRSAYLVAGDTVGLVVQSRKGTAPAVPFRQAVVLQSQLLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JRD0</accession>
    <name>A0A2M9JRD0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CG723_24065</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000009">
        <property type="protein sequence ID" value="PJN09436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN09436">
        <property type="protein sequence ID" value="PJN09436"/>
        <property type="gene ID" value="CG723_24065"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PJN09436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="251" mass="27598" checksum="F64506127D7DD0CC" modified="2018-04-25" version="1">MSFSVGGTVSVETTGRPLRFTPRFDLPGQQLIIAGYADAREREKQLADTFGSMQWLWSENDFLRFDRDSRGLCSATFFLPLRSAPYEAGHGAAALPPSESAGLRANEPSEFELPQAAVFRCAPDGAELVCLRAADLLARQPDARIGIAPDVELLVHDGALTGWRLIDPARCLTSGFSTPDTDSPPSPTTRRHLAECLRLVSAPVVDSVMEQDADAWRDLLALQRAVRDQHDDRRRADVVQAVIDRLVDDNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JRY1</accession>
    <name>A0A2M9JRY1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">TetR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CG723_23090</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000008">
        <property type="protein sequence ID" value="PJN09613.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN09613">
        <property type="protein sequence ID" value="PJN09613"/>
        <property type="gene ID" value="CG723_23090"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="3">
        <location>
            <begin position="46"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="68"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PJN09613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="218" mass="22508" checksum="E8B9A352A68F3B5C" modified="2018-04-25" version="1">MNPSEPQDPQPAAQGSAVVRGGRASSDRSGAVGQGRPANQGRRVAARNRSALIAAAREVFAEQGLNAPLSAVARRAGVGQGSLYRHFADRFALASAVLDENVQQIERAGAEPGASLKGVLGVVTWHLTRSTAFVDLLRVGGDGEQARALAARVRTVLARCLPAGHRLSADDVMLAVAMVSGAVSGPTPAERERVALAAWGLLGVEVGPLRPCEAVVDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JS08</accession>
    <name>A0A2M9JS08_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_20895</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000007">
        <property type="protein sequence ID" value="PJN09670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN09670">
        <property type="protein sequence ID" value="PJN09670"/>
        <property type="gene ID" value="CG723_20895"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014598674" evidence="2">
        <location>
            <begin position="34"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="176"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN09670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="457" mass="47500" checksum="E3C308BB006B0503" modified="2018-04-25" version="1">MRPTRRASRLISVLSGSLLALSAMTAVTPGAQAAASDVSTVADALKKSPVYVDPAASAQLSAGDADALTKKIKDADKPVMVAVLPADFPKQDLFTDLRTKTGVTGVYAIRLGQQFDARADSRVMSQDAVKNLTTSVQGENVTTQLNDFVDTALRNASGSAPSAWGAGGGGDSGAPVGALIAIGAVVVAGGGAAYAVSRRRRKQREDEQRAALEQLRVVVDEDITAFGEELDRLDFHPAEPGADDAMRADYERALDSYEKAKQFMAAAQRPEEVRGVTESLDDGRFSLAMLAARREGRPLPERRVPCFFDPRHGPSVTDARWAPPSGAEREVPVCAADATRLKDGVDPMVRTVDTGYGERRPYYDAGPAYGPWAGGYFGGGILPGLLLGTVLGSMMASPAYAADYGSGYGDFGAGAGYDGGDYSGADFDSNDFGDFGGGGDFGGGGDFGGGGDFGGGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JSC6</accession>
    <name>A0A2M9JSC6_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NADAR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CG723_21480</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CB01635</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>2,5-diamino-6-hydroxy-4-(5-phosphoribosylamino)-pyrimidine + H2O = 2,5,6-triamino-4-hydroxypyrimidine + D-ribose 5-phosphate</text>
            <dbReference type="Rhea" id="RHEA:23436"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:58614"/>
            <dbReference type="ChEBI" id="CHEBI:78346"/>
            <dbReference type="ChEBI" id="CHEBI:137796"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>5-amino-6-(5-phospho-D-ribosylamino)uracil + H2O = 5,6-diaminouracil + D-ribose 5-phosphate</text>
            <dbReference type="Rhea" id="RHEA:55020"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:46252"/>
            <dbReference type="ChEBI" id="CHEBI:58453"/>
            <dbReference type="ChEBI" id="CHEBI:78346"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000007">
        <property type="protein sequence ID" value="PJN09770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN09770">
        <property type="protein sequence ID" value="PJN09770"/>
        <property type="gene ID" value="CG723_21480"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd15457">
        <property type="entry name" value="NADAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012816">
        <property type="entry name" value="NADAR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037238">
        <property type="entry name" value="YbiA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08719">
        <property type="entry name" value="NADAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143990">
        <property type="entry name" value="SSF143990"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02464">
        <property type="entry name" value="ribofla_fusion"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADAR" evidence="3">
        <location>
            <begin position="43"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00000751"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PJN09770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="218" mass="23672" checksum="17D21CD18A49CDE5" modified="2018-04-25" version="1">MSVVRARLACMGKIDKLEGAAAIHDQDSLVRAVEAGVQVKYLYFWGHTPRADGTVGAGCLSQWWVAPFTVDGVEYATAEHWMMAAKARLFGDAEAERRAVGAAHPSQAKKAGRLVRGFDEDVWARERFGIVVEGSVHKFAAHADLREFLLGTGERSERGVPRPKGGGRVLVEASPLDRVWGIGLAADAEAAADPRRWRGPNLLGFALMAARERLADRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JSK1</accession>
    <name>A0A2M9JSK1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Rossmann fold nucleotide-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CG723_21415</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000007">
        <property type="protein sequence ID" value="PJN09856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN09856">
        <property type="protein sequence ID" value="PJN09856"/>
        <property type="gene ID" value="CG723_21415"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041164">
        <property type="entry name" value="LDcluster4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031100">
        <property type="entry name" value="LOG_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18306">
        <property type="entry name" value="LDcluster4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03641">
        <property type="entry name" value="Lysine_decarbox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PJN09856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="367" mass="38652" checksum="060D1BCB33E29D83" modified="2018-04-25" version="1">MPHTDAGREIETLDEFDEVVAAHGSLAGRRVQAVDLTERTDELLALDAEGAVFLGCPMGPDAAARIRATGALVFPPVPGLPFDPYRGHLYSPAELFAGLAEGGYESTPDARAYDWFQQTKADHDIFASMLRAVHDDSVSDALDELLAGARVVGVMGGHAMARGTDGYAGAARLGRTLARSGVTVATGGGPGAMEAANLGAYAARFDDAMLTQALQLLAAAPSFTPSVTAWASAAFAVRSRWPDGGDSVGIPTWFYGHEPPNAFAGHIAKYFANATREDGLLARSNAGVVFLPGAAGTVQEIFDNATPNYYESRGEPTPMVLVGRAHWTERLPAWPLLTALARERSMDARIALVDTVEEAADALAKLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JSL3</accession>
    <name>A0A2M9JSL3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Type VII secretion integral membrane protein EccD</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">eccD</name>
        <name evidence="7" type="ORF">CG723_21850</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CB01635</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the EccD/Snm4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000007">
        <property type="protein sequence ID" value="PJN09865.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN09865">
        <property type="protein sequence ID" value="PJN09865"/>
        <property type="gene ID" value="CG723_21850"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044049">
        <property type="entry name" value="EccD_transm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006707">
        <property type="entry name" value="T7SS_EccD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024962">
        <property type="entry name" value="YukD-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19053">
        <property type="entry name" value="EccD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08817">
        <property type="entry name" value="YukD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017804">
        <property type="entry name" value="Secretion_EccD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03920">
        <property type="entry name" value="T7SS_EccD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="3 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="140"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="172"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="198"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="229"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="255"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="280"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="346"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="371"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="400"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="441"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="473"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="domain" description="EccD" evidence="6">
        <location>
            <begin position="114"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF19053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PJN09865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="504" mass="51916" checksum="2456F6A0162A7BC3" modified="2018-04-25" version="1">MTASASATAGATGGAGTGAPSGAGTGLGFCRVTIVAPDSRIDVALPDDVPVADLNPEILRLSQQSPAEGAPVGYHLVRRDGTVLDSARSFAAQRILDGELLTLRPFSESLPPAVFDDVSEAVASAVTRDRTLWNGDLTRGAGLIGGGVLPALLAFVTWTAEPHHNMNSLQGVLAAVAGLLLVVLACVRARVYDDRGSAIALGLGALPNVAVAGSGLLPLADHQGIGRLQFLLACTAVLLASVVLTLVSPGGDGPFVAFVFASAVGVLTTFIAILTDLTAVETAGLCAPLSVGALAFLPGLSMRFARLPIGFEPPSMARGEYGDDPANQEPVEADRIAAQARRGHELLVGLVGGCALVSVGAAAVLGFSHDVWGQLLAFATGVAMLMRAQLFRYTAQVASLLAAGLASLVLLGLGLSLHPPVDYLTDFFMKNDPTALNIRTVWLVAVIAAATALITSIGLITPRRGVSPFWGRFMEIAETFVLLTLVPLTLAVFDVYTKARSMTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-05-25" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JSV2</accession>
    <name>A0A2M9JSV2_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ornithine aminotransferase</fullName>
            <ecNumber evidence="3">2.6.1.13</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Ornithine--oxo-acid aminotransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">rocD</name>
        <name evidence="7" type="ORF">CG723_19675</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CB01635</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-proline biosynthesis; L-glutamate 5-semialdehyde from L-ornithine: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.13" evidence="3"/>
    <dbReference type="EMBL" id="NNBL01000006">
        <property type="protein sequence ID" value="PJN09950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN09950">
        <property type="protein sequence ID" value="PJN09950"/>
        <property type="gene ID" value="CG723_19675"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00098">
        <property type="reaction ID" value="UER00358"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050155">
        <property type="term" value="F:ornithine(lysine) transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004587">
        <property type="term" value="F:ornithine-oxo-acid transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055129">
        <property type="term" value="P:L-proline biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00610">
        <property type="entry name" value="OAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005814">
        <property type="entry name" value="Aminotrans_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010164">
        <property type="entry name" value="Orn_aminotrans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11986:SF18">
        <property type="entry name" value="PTHR11986:SF18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00202">
        <property type="entry name" value="Aminotran_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000521">
        <property type="entry name" value="Transaminase_4ab_Lys_Orn"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01885">
        <property type="entry name" value="Orn_aminotrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00600">
        <property type="entry name" value="AA_TRANSFER_CLASS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00030587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PJN09950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="405" mass="43280" checksum="D50B777B6A9D39C2" modified="2018-04-25" version="1">MTPPNAVTETFITASEAHSAHNYHPLPVVVATAEGAWMTDVEGRRYLDLLAGYSALNFGHGNRRLIEAAKAQMDRVTLTSRAFYHDRFAEFCAQLAELCGMDMVLPMNTGAEAVETAVKTARKWGYQVKGVLDGRAKIVVAGNNFHGRTTTIVSFSTDQEARADFGPYTPGFEIVPYGDLTALRGAVTENTVAVLLEPIQGEAGVLVPPAGYLPAVRELTRERNVLFIADEIQSGLGRTGRTFACEHEGVVPDMYVLGKALGGGVVPVSAVVSSSEVLGVFKPGEHGSTFGGNPLACAVALEVIAMLRTGEFQQRATELGEHLHAELGLLAGTGKVTQVRGRGLWAGVDIDPSYGTGREISEKLMDKGVLVKDTHGSTIRIAPPLVISKEDLDWGLDQLRAVLAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JSZ9</accession>
    <name>A0A2M9JSZ9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Serine/threonine protein kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CG723_19965</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000006">
        <property type="protein sequence ID" value="PJN10000.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN10000">
        <property type="protein sequence ID" value="PJN10000"/>
        <property type="gene ID" value="CG723_19965"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="580"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="3">
        <location>
            <begin position="1"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="61"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="203"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="268"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="519"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="605"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="63"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="222"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="295"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="540"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="638"/>
            <end position="667"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PJN10000.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="817" mass="87228" checksum="7E5472D5D3862846" modified="2018-04-25" version="1">MEDYAGRVLADRYRLPLSPADAYEFASTRAFDTYSGQEVLVRQVPLPEVVEAEVLDAEGLPDGFVPRESRGRRERGDAARTTRRPTDPAVRRAVEAAQAAAQIPDHPRLDQVFDVFAEGGSLWIVSEVVSARPLAALLAEEPLSPYRAAEVASDVLTALRALHAHGWVHRNITARTVLVCDDGRIVLTGLAAGAAEEALCGYDPTPAPPAAPSEPQDPQSSAPASPYTPPAPFAPAPSRPAALEAGSDPRAARAGAIAAYRAGARAAARGGVDTDGTPGPPQRGPGGESGAGTHRDDAQSGRIDDPYGVRGSAERPWHGAIPRPGMEQAEPAALEAPDSAPESTRWDQLIPAQQTASTAGRGPATALAADRARQARMTVVGPVTERWAPEQAGPVHENWQLAAPIGPATDLWALGALLFRAVQGHAPYPEENTGELVQMVCAEPPAFAEECGPLRPVVESLLRQDPTERLDFEELRGWLRSLVRSAPEPEAGANVVVAPPFDATRLPIVRRRGELVRRRRWRSSAQAGAGPGHARHKRAKAQPQQAERRTRPERRPPSERERRPQSERGPRKPRSLGRTLLVLVLLGLAAAVAYAVLFMPKAEPSGGTPGDGGKDHAGATGGGRPAPEGGRSTPAPSAGESAGKSGGNSSSTPSATDPQTDSSEPEVAQGFTLRKDPEGFRVAVAKGWNRQGRNGQGQVLYTHGDFELVVVPGRDSTSAYGSDPMTYQREKERELQPFRDSTWATSSGMRRIDVGGRAMAEGQFTWQNSAGRETYVRNLAMIVGGRYHVVQLRGPEAERDEVTRLYEQASATYQNTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JTQ1</accession>
    <name>A0A2M9JTQ1_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF6299 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_17785</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000005">
        <property type="protein sequence ID" value="PJN10243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN10243">
        <property type="protein sequence ID" value="PJN10243"/>
        <property type="gene ID" value="CG723_17785"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046266">
        <property type="entry name" value="DUF6299"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19816">
        <property type="entry name" value="DUF6299"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014818975" description="DUF6299 domain-containing protein" evidence="1">
        <location>
            <begin position="24"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6299" evidence="2">
        <location>
            <begin position="29"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF19816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN10243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="144" mass="15081" checksum="2DE9DE5C7BBC2469" modified="2018-04-25" version="1">MRLPALALAALTAVVVLSPSASADSFSGSISAHQLARIAPDGTLTLSGTYRCETSSSARAVFVSSNLVQDNKRLGFGSTEARCDGQEHEWSSSGPVDGLMDLGFHEGRAAVDAHLMTLESDGGLPMPRALAGQEEPVRLVDDRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JU66</accession>
    <name>A0A2M9JU66_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">GntR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CG723_18530</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000005">
        <property type="protein sequence ID" value="PJN10368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN10368">
        <property type="protein sequence ID" value="PJN10368"/>
        <property type="gene ID" value="CG723_18530"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07377">
        <property type="entry name" value="WHTH_GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.530">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011711">
        <property type="entry name" value="GntR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008920">
        <property type="entry name" value="TF_FadR/GntR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07729">
        <property type="entry name" value="FCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
        <property type="entry name" value="GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00035">
        <property type="entry name" value="HTHGNTR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00895">
        <property type="entry name" value="FCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00345">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48008">
        <property type="entry name" value="SSF48008"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50949">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH gntR-type" evidence="5">
        <location>
            <begin position="21"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="244"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PJN10368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="274" mass="29434" checksum="60C0B8C0C3CF74C0" modified="2018-04-25" version="1">MTVNRDKTGVRRAVFTPVDTLARVDAVVRRLGDAIDLGLLADGEQLPGESDLAAQLGVSTVTLREALMALRQRGLVTTRRGRGGGSFVTVPDGPAEDRLLARLADWSTEELRDLADHWAAVSGAAARLAARRTEPADLRQLQRSLGELMDAKESGARSRIYGRFHVELAAAAQSARLTREEVTLQTEVGALLRLVLHDDDLLADAADRHRAVISAVHDGADDRARALAEQCVQTSMARLIELRLGPAGDASGPRPKEAPDGQQPPSRTRRIGAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-09-29" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JUC4</accession>
    <name>A0A2M9JUC4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CG723_18870</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CB01635</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000005">
        <property type="protein sequence ID" value="PJN10422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN10422">
        <property type="protein sequence ID" value="PJN10422"/>
        <property type="gene ID" value="CG723_18870"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000849">
        <property type="entry name" value="Sugar_P_transporter"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002808">
        <property type="entry name" value="Hexose_phosphate_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="33"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="70"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="188"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="254"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="289"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="329"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="353"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="385"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="415"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="7">
        <location>
            <begin position="33"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PJN10422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="445" mass="46740" checksum="2E630E098988147D" modified="2018-04-25" version="1">MSQVNPVHSTDERTGADAGPAPAARPTRTRWKVFVLLLAVVALNYIDRGSVSVALPLITEDLHLSKEVTGFVLSAFFWTYALMQIPSGWLIDRFGPRYMAGGACVGWGVATGLTGAATGVGSLLGFRLLLGAVEAPVMPAGGKLNANWLPAKERGRGAVLMDGGAPLGSALGGIAISGLIAWTGSWRISFVVAGVLTAAIGFFALWFLRDTPRAHRGVNAAEADYIDRAHAAEDAAAGTDRRARLRAYLKYRSFWGMCLGWMGFNGVFYGILTWGPLYLSETKGFDIKTIGWSTLAIFGAGFVGELTGGWISDRWQATGAGANRVMRTLMGIAGAAVVAGLLGVVLVPDALTAVALLSGVLFFLRWAGLYWSLPSILGGRANAGVVGAAMNLSGNIAGIVTPIAVGFIVGGTGSYTWALLYFVAAGVLFTVSSLVIDYSRRLATR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JUE2</accession>
    <name>A0A2M9JUE2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CG723_18095</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CB01635</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000005">
        <property type="protein sequence ID" value="PJN10489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN10489">
        <property type="protein sequence ID" value="PJN10489"/>
        <property type="gene ID" value="CG723_18095"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="68"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="104"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="147"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="187"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="243"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="69"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PJN10489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="279" mass="30561" checksum="5074690DF81212FD" modified="2018-04-25" version="1">MASPRSFIWSRRIFLTLLTGFVLLPVYVMISSSLKPLEDVSGKFRWMPSGLTIRPYFDIWKTVPLAKYFLNSLIVAGAATVCSVVIAVFAAYAVSRYQFRGKRVFTVTVLSTQMFPGILFLLPLFLIYVNIGQSTGIALFGSRGGLILTYLTFSLPFSIWMLIGYFESVPRDLDEAAMVDGCGPLKALFRVVVPAAIPGIVAVAVYAFMTAWGEVLFASVLTTDTTRTLAVGLQNYSTQNDVYWNQIMAASLVVSIPVVAGFLLLQRYLVAGLTAGAVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-06-02" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JUS6</accession>
    <name>A0A2M9JUS6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_15585</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000004">
        <property type="protein sequence ID" value="PJN10634.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN10634">
        <property type="protein sequence ID" value="PJN10634"/>
        <property type="gene ID" value="CG723_15585"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="60"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="66"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN10634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="86" mass="9726" checksum="F40CF331F436DF87" modified="2018-04-25" version="1">MIEPSDDNFILSSRELSAIELDILMEGRQAEAKKILDLHELSEDSLPHHHPGLAESIQRLPEDLQSPVQGDEDRSEDWPDAPSRDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JUX3</accession>
    <name>A0A2M9JUX3_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA (cytosine-5-)-methyltransferase</fullName>
            <ecNumber evidence="2">2.1.1.37</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CG723_15610</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CB01635</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 2'-deoxycytidine in DNA + S-adenosyl-L-methionine = a 5-methyl-2'-deoxycytidine in DNA + H(+) + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:13681"/>
            <dbReference type="Rhea" id="RHEA-COMP:11369"/>
            <dbReference type="Rhea" id="RHEA-COMP:11370"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:85452"/>
            <dbReference type="ChEBI" id="CHEBI:85454"/>
            <dbReference type="EC" id="2.1.1.37"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.37" evidence="2"/>
    <dbReference type="EMBL" id="NNBL01000004">
        <property type="protein sequence ID" value="PJN10638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN10638">
        <property type="protein sequence ID" value="PJN10638"/>
        <property type="gene ID" value="CG723_15610"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003886">
        <property type="term" value="F:DNA (cytosine-5-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009307">
        <property type="term" value="P:DNA restriction-modification system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001525">
        <property type="entry name" value="C5_MeTfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00145">
        <property type="entry name" value="DNA_methylase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00105">
        <property type="entry name" value="C5METTRFRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51679">
        <property type="entry name" value="SAM_MT_C5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6 8" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0680">Restriction system</keyword>
    <keyword evidence="6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4 6 8" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="213"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PJN10638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="331" mass="35436" checksum="34709BF40161F54F" modified="2018-04-25" version="1">MGALSFVDVCAGAGGLALGLEQAGFEPRLLLDNDKRTVATLTANRPHWNVLLEDLLDFDPIEHPESYDVDLLSAGLPRVKSSATVGRPDSGEEERLLRATIFLAHAIKPRAVLIDNVPDLAYSDDYKPFRDFARAELAHLGYEFSWFVVDAVGFGVPQNRRSGVLVALERGHGDAFRPPIPTVDEPTTVGAALQRSMSARGWPDAARWAAQADRPAPTLVGGSKNRGGADLGPTGSKKKWATMGVNGHTLGDQVPGEDFVWDPERGREYLVKITPEQAATLQGFPESWSISGPKTPRYRQIGHALPPPVGRALGGAVADALKGDPACLPAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JV27</accession>
    <name>A0A2M9JV27_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Sugar ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CG723_16205</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000004">
        <property type="protein sequence ID" value="PJN10733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN10733">
        <property type="protein sequence ID" value="PJN10733"/>
        <property type="gene ID" value="CG723_16205"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="20"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="266"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="512"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="52"/>
            <end position="59"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PJN10733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="532" mass="57063" checksum="2C0A89F82B0E2B39" modified="2018-04-25" version="1">MSNPEKRPGQEPAEPADELLRIEGIRKTFPGVVALDSVDFDLRRGEVHVLLGENGAGKSTLIKMLSGAYRPDAGRIVVDGQEARIHGAQDAERLGIATIYQEFNLVPDLTVAENIFLGRQPRRLGLIDRKKMEADAEELLRRVGLTVSPRARVRELGIARLQMVEIAKALSLDARVLIMDEPTAVLTSEEVDKLFGIVRALREDGVGVVFITHHLEEIAALGDRVTVIRDGRSVGQVPASTPEAELVRLMVGRSIEQQYPRERPRLDATDAPLLRVEGLTRDGVFHDVHFEVRAGEVVGIAGLVGAGRTEVVRAVFGADPYDKGTVEVAGARLPRHDVNAAMAAGVGLVPEDRKGQGLLLDASVEENLGLVTLRSATRAGLVDRKSQRVAAARMAEQLGVRMAGLGQHVRTLSGGNQQKVVIGKWLLADIKVLILDEPTRGIDVGAKVEIYQLVNELTAAGHAVLMISSDLPEVLGMSDRVLVMAQGRIAGELAAGEATQDSVMALAVSTAASPASPATTPEHNEVEGSRGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JVM2</accession>
    <name>A0A2M9JVM2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_16485</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000004">
        <property type="protein sequence ID" value="PJN10951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN10951">
        <property type="protein sequence ID" value="PJN10951"/>
        <property type="gene ID" value="CG723_16485"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002731">
        <property type="entry name" value="ATPase_BadF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01869">
        <property type="entry name" value="BcrAD_BadFG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BcrAD_BadFG" evidence="1">
        <location>
            <begin position="8"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN10951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="324" mass="33535" checksum="28706F53CFABF5A1" modified="2018-04-25" version="1">MNGWVLAIDAGNSKTDVAVVAADGSVVGAARGGGFQPPKVGVEAAVDVLAEAVDRALTEAGTTTVGHVSACLANADLPVEERELAAELRARGWAASVDVRNDTFAVLRAGLLKDSEPRGVAVVCGAGINCAGMLPDGRTARFPAIGKISGDWGGGGGLAEEALWYAARAEDGRGDATALMHSLPAHFGLPSMYALIEALHLGRIPVQRRHELTPVLFATAADGDPVARALIDRMGDEVVAMSVVALDRLGLLDEETPVLLGGSVLAARHPQLDDRIREMLTARAPKAVPRVVTARPVLGAALLGLDAVGADEDVHARVRAHFES</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JVN9</accession>
    <name>A0A2M9JVN9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_16785</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000004">
        <property type="protein sequence ID" value="PJN10827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN10827">
        <property type="protein sequence ID" value="PJN10827"/>
        <property type="gene ID" value="CG723_16785"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="87"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="155"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN10827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="214" mass="22294" checksum="94B64761278105BE" modified="2018-04-25" version="1">MWYAHNPGRRALQLLGDGAALLWIALWAAAALAAHQLAQLASQPAQRRPRIPLLGSSVDGALRGVAHAGDRIVSAAPAPQGPAAAQALAVLGAVALFVIPVGLMLTVWLPRRIRWTRQAAAAQELASTEDGRELLALRALLRPLDELAATAELLPAAPGGTPDQDPDPGVDPDLDLDVPPDPGPGSLAKGWREADPVVLDALADAELQRLGLRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JW90</accession>
    <name>A0A2M9JW90_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Abhydrolase_3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_09445</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN11165.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN11165">
        <property type="protein sequence ID" value="PJN11165"/>
        <property type="gene ID" value="CG723_09445"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013094">
        <property type="entry name" value="AB_hydrolase_3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07859">
        <property type="entry name" value="Abhydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Abhydrolase_3" evidence="1">
        <location>
            <begin position="65"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN11165.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="305" mass="32046" checksum="135A3FBB28F786C9" modified="2018-04-25" version="1">MTRTLRELIAAPHPDVGPLPPAAEHPAGVRVLRGVPYGVLEGSRPLELDLWLPPTPEPPRPSPVVLFVHGGAWRRGRRDDMGLHTRAWDPGPFELIAAAGFTVACVDYRLSGEATFPAPLADLRTALRWLNVRAPELGTDPRRTVVWGESAGGHLASLLALTHDEPPLAGAVVWYGPADLTSARDPFDPADAATPEALLLGAAPADAAQLARAASPLKNAHAGAPPFLVVHGEDDSMVACSHGRDLAAALIGAGAPVELWTIPGADHGWHGLDQGSVTQIFTRSLEFALRVAGRPDSVAGNNATL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JWG1</accession>
    <name>A0A2M9JWG1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Long-chain fatty acid--CoA ligase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_09855</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN11235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN11235">
        <property type="protein sequence ID" value="PJN11235"/>
        <property type="gene ID" value="CG723_09855"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-binding" evidence="1">
        <location>
            <begin position="11"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding_C" evidence="2">
        <location>
            <begin position="417"/>
            <end position="493"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN11235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="506" mass="54029" checksum="8F2B6B7F515399D4" modified="2018-04-25" version="1">MATLSLAAILAESARRRPDKAGLVQGDLRITFKELWLQARKQAAALIGLGVRPGDKVALMAPNVAEFPRAYYAALAAGAVVVPVHLLLSAGEVEHVLRDSGATLLLCHPGQAKTGGAAAEATGVRMLTLGEGGDLERLTHDAEPLPTYLTRDADDPAVVFYTSGTTGVPKGAVLSHFNLVMNATVSAFDGHDVRSDDIALGALPLFHAFGQTVSMNATWRAGATLVLLPRFDAAKAIDLMVAEGVNTFHGVPTMYVNLVAAAAAAEKLPTLKVCVSGGASLPVAVLERFQEAFGATVYEGYGLSETSPAAATNQPVFGARPGTIGHPMWGIDVEIARAEVEDRVELLPEGELGEVVVRGHCVFTGYLGRPEATAEALVDGWFRTGDLGTKDEDGYLRIVDRKKDVIIRGGYNVYPREVEEVLMRHPAVAQVAVIGLPDPVHGEEVCAVIIRKETDGIAAGADEITEWSKEHLGRHKYPRRIEFADELPLGPSMKVLKRELRAQYTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JWS9</accession>
    <name>A0A2M9JWS9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Serine hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_10540</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN11355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN11355">
        <property type="protein sequence ID" value="PJN11355"/>
        <property type="gene ID" value="CG723_10540"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001466">
        <property type="entry name" value="Beta-lactam-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00144">
        <property type="entry name" value="Beta-lactamase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Beta-lactamase" evidence="1">
        <location>
            <begin position="19"/>
            <end position="389"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN11355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="410" mass="44874" checksum="4CFF2E18C055F33D" modified="2018-04-25" version="1">MMGTGISGFTKTGLNRVHDVLSRHVDSGKIPGLVALFSRGDESHVETIGTVRHDGGAPMRRDTIFRMASTSKPVSIAAAMVLLDECRLRLDDSVDQWLPELADRQVLKRVDGPLDETVPARRPITVRDVLTSTFGLGMDMTVLGTPIMNAVFEQGITPNLPEPMPEPDEWMRRLGTLPLMYQPGECWQYQISSDLVGVLVARVTGQSFESFLSERVFEPLGMKDTGFHVPADQLHRLPPLYAPDPGTGEFQVWDEAETGRHSAPPAFQGGGGGLNSTADDYHAYFRMLLNGGMHEGERILSRAAVELMTTNRLSPEQHAARHKLAVDNVHVSHGQGQHGGWGFGMAVRTYRGDYAPIGQFGWDGGSGTSTYADPDNQLTGILLTQVGASVPDPVHLMLDFWTTLYQAIDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-09-29" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JWY8</accession>
    <name>A0A2M9JWY8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Phosphohydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CG723_09995</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN11257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN11257">
        <property type="protein sequence ID" value="PJN11257"/>
        <property type="gene ID" value="CG723_09995"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP_ApaH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025142">
        <property type="entry name" value="DUF4073"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13285">
        <property type="entry name" value="DUF4073"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="SSF56300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014715278" evidence="1">
        <location>
            <begin position="35"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="domain" description="Metallophos" evidence="2">
        <location>
            <begin position="52"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4073" evidence="3">
        <location>
            <begin position="267"/>
            <end position="345"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PJN11257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="351" mass="38615" checksum="B1036973FA16F3D2" modified="2018-04-25" version="1">MDRRSFMATTGRATLAGGALAATGSLVSAPAADAAPAAEPAAQRHGDGGTVRFNIISDIQGDLTDFGKALDDLHSVNPRSAGLGIAGDITPRGYDFEYAAVRQTLDKHPHPKNVAWAIGNHEFYVPKYSDPNTLAQATWPNGTTEDSLFRSFYHFAERGKVYSETSFGGVPVLSLGTERYSHYHDAKLWDEVWISDEQFAWLEDRLAHWARRRRPVMVLTHHPLPNTVSGTHNKLYMSDYLQPDRLLSILGRHKDVFLFSGHTHWDLNLSDWVVRRVVPGTANPEGFTVVNTAAVQVGWMDDGKGGEVSLGGAFNQGLQVEVGPRSVVIKARDFTTGTWIKQITVPLHTSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JX89</accession>
    <name>A0A2M9JX89_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alkanesulfonate monooxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_11420</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN11504.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN11504">
        <property type="protein sequence ID" value="PJN11504"/>
        <property type="gene ID" value="CG723_11420"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011251">
        <property type="entry name" value="Luciferase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036661">
        <property type="entry name" value="Luciferase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00296">
        <property type="entry name" value="Bac_luciferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51679">
        <property type="entry name" value="SSF51679"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bac_luciferase" evidence="1">
        <location>
            <begin position="4"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN11504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="381" mass="41320" checksum="4B1AEF8B7A2D131B" modified="2018-04-25" version="1">MSLTFHWFLPTNGDSRHVVGGGHGTPVTAAGGDRPPSIGYLTQIARAAEDLGFVGALTPTGAWCEDAWLTTAMLSQQTERLKFLVAFRPGFVSPTLAAQMASTYQRQTGGRLLLNVVTGGESREQRAYGDFLDKESRYARTGEFLEIVRGLWAGDTVDLAGEHLQVQDARLARLPDPVPEVYFGGSSPVAGEIAARHSDVYLTWGEPPAQVAEKIAWIRGLAEKEGRTVRFGIRLHVITRDTAEQAWAEADRLLQGFDPATVRSVQEGLARSESEGQQRMLALHGGSSNSLEIHPNLWAGIGLVRGGAGTALVGSHDEVADRVEEYHRLGIDEFVLSGYPHLEEAYWFGEGVLPRLQARGLWAHPHRGAAALTAPQVPFGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JXH7</accession>
    <name>A0A2M9JXH7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_11915</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN11589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN11589">
        <property type="protein sequence ID" value="PJN11589"/>
        <property type="gene ID" value="CG723_11915"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="112"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="154"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="194"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="223"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="263"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="289"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="24"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN11589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="326" mass="34323" checksum="807C70AE86B6C395" modified="2018-04-25" version="1">MATGGWGPGNGPQNNGGQAPAGPGPGNPYGPPPTGPYGPQPGAGPYGPPQPIPPQVGPYPYGPPRPPVPPRRRNPLRRVPFLNIISAIIHSGHRVATRLFVQDGGVRINDPLVLRVQLFRSVLGLVATLVLAFYYGKGEQAWNGAASDGFGNLIITPVLLIVTGPLVVLGFILYAPPHLRSALCSRLKGPLKTVAWYVLSVAVFAAVIVVAATSGYLDKLPKWAAAVSALVVLAVIVWGLPFLFFASLYSAKTAFNTAHVHPMLPAVLTAVLVWAVAVFNLIVEGMPEGPVAAQLCSLLGGPLSVTAVSLWELRRMRTRHGVVLRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JXS0</accession>
    <name>A0A2M9JXS0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Phosphotransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_12445</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN11673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN11673">
        <property type="protein sequence ID" value="PJN11673"/>
        <property type="gene ID" value="CG723_12445"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="APH" evidence="1">
        <location>
            <begin position="37"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN11673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="299" mass="32201" checksum="374978A28F01430A" modified="2018-04-25" version="1">MCPRKLRPEEADIDASLVRRLVDAQFPQWAGLPLTEVVSAGTSNAMYRLGEDMAVRLPRLAGSAQDVEKEHRWLPLLAGALPVAVPTPLGKGNPGEGYPWPWSVYRWLDGANPAPDLTPEPVLLAEDLAEFVSVLQRVDPTGGPASYRSEPLAERDEVTRAAIRELRAELDGDAASAVWESALRAQEWAGPAVWIHADLQPGNVLVADGRLSAVIDFGCLGLGDPAVDLIAAWYLLPAGAREVFRTGSGSDDDAWARGRGWALSVALLELRSYRESNPVMASIARQVIAELLTDDTAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JXV1</accession>
    <name>A0A2M9JXV1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CG723_12440</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN11672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN11672">
        <property type="protein sequence ID" value="PJN11672"/>
        <property type="gene ID" value="CG723_12440"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PJN11672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="181" mass="20150" checksum="6954F8E7F38D7811" modified="2018-04-25" version="1">MTGSEHLPLLFLDVDGPLIPFGGPPECYPTYPMCRPGGPDPLGADLNPLLARINPEYGPRLAALPCELVWATTWMEEANDCVAPLLGLPPLPVVDWPDPPVRDARDEWHGVRGLHWKTRALVGQAQGRPFAWVDDEITDIDRAWVFAHHAERALLHRVDPRRGLTEADFACLDEWLRAAAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JY37</accession>
    <name>A0A2M9JY37_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Chaplin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CG723_13015</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN11768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN11768">
        <property type="protein sequence ID" value="PJN11768"/>
        <property type="gene ID" value="CG723_13015"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007155">
        <property type="term" value="P:cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005528">
        <property type="entry name" value="ChpA-H"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03777">
        <property type="entry name" value="ChpA-C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51884">
        <property type="entry name" value="CHAPLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0034">Amyloid</keyword>
    <keyword evidence="2" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014935557" evidence="5">
        <location>
            <begin position="27"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="domain" description="Chaplin" evidence="6">
        <location>
            <begin position="37"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PJN11768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="78" mass="7703" checksum="760812A41DB9FE47" modified="2018-04-25" version="1">MRIRTFIVTAALGAATVLAGAGVASADSDADGFAVGSPGFLSGNVIQVPIDVDANICGNSVNVIGLLNPAIGNYCSNH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JYC5</accession>
    <name>A0A2M9JYC5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CG723_13675</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN11874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN11874">
        <property type="protein sequence ID" value="PJN11874"/>
        <property type="gene ID" value="CG723_13675"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012551">
        <property type="entry name" value="DUF1707"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08044">
        <property type="entry name" value="DUF1707"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PJN11874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="180" mass="19828" checksum="0F0E2D1C4A573563" modified="2018-04-25" version="1">MNLPQENPARPISEDDRNTAVQRVQEAYAEGHLSHEEMDERLQQVLTAKTHSDLGPALASLPQEDAGTSSTIGALGGRIQRRGAWRVPRNLKVESAFGSVRLDLSRAVFEHPAVDIELQVGTGRAKITVPRDAIVDVEGLHTGWKDLRYKVPRSSGQGGPRIRISGTMGFGRLKIRHARR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JYM0</accession>
    <name>A0A2M9JYM0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CG723_14210</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN11965.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN11965">
        <property type="protein sequence ID" value="PJN11965"/>
        <property type="gene ID" value="CG723_14210"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="7"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="221"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="251"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="39"/>
            <end position="46"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PJN11965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="281" mass="30420" checksum="D4CED5562073EBE5" modified="2018-04-25" version="1">MSEDPAVCCRGLEYAFGETRAVDGLDLTVGPGEVFGLLGPNGAGKTTAIRCITTLLPVPRGRVSVFGHDAATERMAVRRLLGYVPQQLSADSGLTGRENVTLFARVFDVSRRERARRVAQALAAVDLTDAADRLAKTYSGGMVRRLELAQALVSAPRLLILDEPTIGLDPIARTSVWDHINAVRGATGMTVLVTTHYMDEADQYCDRVALMHRGRVHALGTPDGLRRDLHEQRGNAGSQEPWPTLEDVFRDVAGRGLDSDGGEGGDFRDVRSTRRTASRLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JYN3</accession>
    <name>A0A2M9JYN3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GNAT family N-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_14330</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN11984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN11984">
        <property type="protein sequence ID" value="PJN11984"/>
        <property type="gene ID" value="CG723_14330"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="12"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN11984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="173" mass="18634" checksum="2C29711471C96A68" modified="2018-04-25" version="1">MDLIYEKSGVAVSVRTACVGDAEAVRVIRNDAIEHSTALWTTRTQTSAEAAAWLTTHLNRGSAFVAEVDGEVAGFAVYGPWKDFDGFCHTVENSVYVREGLHGLGIGSALLTVLISGARKAGHHVVIAGIEGSNTASIRLHERFGFQHAGTVREVGTKFGRWLDLTLMRLLLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JYS6</accession>
    <name>A0A2M9JYS6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Epimerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_13865</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN11907.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN11907">
        <property type="protein sequence ID" value="PJN11907"/>
        <property type="gene ID" value="CG723_13865"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Epimerase" evidence="2">
        <location>
            <begin position="6"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="336"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="343"/>
            <end position="359"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN11907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="359" mass="38623" checksum="9167EA1CAA594103" modified="2018-04-25" version="1">MNNDLVLVTGGSGYLGSHVVKRLLDEGFPVRTTVRSMNRADDVRAMVGPRAERLEFAQANLTDDAGWEDAVDGCTYVAHVASPFPPAQPDDPDELIVPARDGALRVLRAARDAGVKRTVLTSSFAAVGYSRKPGEVYTETDWTDPADDNTPYVRSKAIAERAAWDYIEAEGGGLELSVINPSGIFGPLLGPHLSASTGLVKAMLDGAMPVVPPVYFGVVDVRDVADIHVRALTHPAAAGERFLASNGPAISFLQLARILREHLGEAAARVPTRELTPDEVREAAVSNPTLRDAVRQSGGIPVLHTAKARTMLGWEPRDTATTIVDTARSLIQLGLCEGETPRPPHRAVSRPKEPRSRIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JYY5</accession>
    <name>A0A2M9JYY5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Short-chain dehydrogenase/reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_14880</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN12076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN12076">
        <property type="protein sequence ID" value="PJN12076"/>
        <property type="gene ID" value="CG723_14880"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN12076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="269" mass="28607" checksum="59BC939BF5B8CCB2" modified="2018-04-25" version="1">MSKTVLITGASTGMGEALTFEYVERGWNVSATMRDTAKANPAFADLDKVLVTRLDVTDRAGIEKAVQETVTRFGTIDAVVNAAGYGQLGAVEEVSVDQLRDQLETNVVGVVQVIQAVLPHMRERGSGHIINIGSMGGHVSLPTMAVYCASKSAVQNLTEGLAQEVGPLGVHVTLVEPAGYDTNFTASSKFPATSIADYADSYATMAEFDKQAVRGDLVKSMAAVADITDVDEPPLHLAVAPASLEMVRGRFAELMAEYDRWEPVTAATL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JZ58</accession>
    <name>A0A2M9JZ58_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GntR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_11050</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN12151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN12151">
        <property type="protein sequence ID" value="PJN12151"/>
        <property type="gene ID" value="CG723_11050"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07377">
        <property type="entry name" value="WHTH_GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1410.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028978">
        <property type="entry name" value="Chorismate_lyase_/UTRA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011663">
        <property type="entry name" value="UTRA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
        <property type="entry name" value="GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07702">
        <property type="entry name" value="UTRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00345">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00866">
        <property type="entry name" value="UTRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64288">
        <property type="entry name" value="SSF64288"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50949">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH gntR-type" evidence="1">
        <location>
            <begin position="22"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN12151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="256" mass="28006" checksum="60C4E0AE68BB35FE" modified="2018-04-25" version="1">MPAERIPASLPVAAARRRRLRADQARQLADLLRHQILSGGFPRGVLPLEDIIAADYRASRNTVRQALDLLRGEQLVERKAGVGTVVVCEKYPHGLDRLQGLAETLHEHGRVTNEVRTVGPVSAPGPVARRLGLPDHTDVLCIERLRRLNGLPLSLDLSYLPMDLGGELLGCDLENTDVFRLLETLTGGPLGHAEITLEAVNADAHSAAVLEAPRGSAVLMLERLTHLPDGRPVDLEFIRFRGDRITMSGVLRRHSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-06-02" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JZ82</accession>
    <name>A0A2M9JZ82_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">GntR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CG723_12345</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN12179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN12179">
        <property type="protein sequence ID" value="PJN12179"/>
        <property type="gene ID" value="CG723_12345"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.530">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011711">
        <property type="entry name" value="GntR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008920">
        <property type="entry name" value="TF_FadR/GntR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07729">
        <property type="entry name" value="FCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
        <property type="entry name" value="GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00895">
        <property type="entry name" value="FCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00345">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48008">
        <property type="entry name" value="SSF48008"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50949">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH gntR-type" evidence="5">
        <location>
            <begin position="42"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PJN12179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="277" mass="29696" checksum="085A7FAC37C3D7AA" modified="2018-04-25" version="1">MPRARHTRCSDSHRRCDNRQRTGTGSPAHDAHDDTGSGVELQGLHGQVVDRIGLSLAADEIRAGEVLRLEDVQERYGVSRTVAREAVRVLESKRAVTSRPRIGITVRPMPEWNLYDPQVIRWRLASPRREVQLRELAELRAAVEPSAAALAAASGDAEARQALSEHARVMASAARAGDSAGFVEADAAFHRALLGASGNGMFAQLAEVTQELLVARRELSLMPHDIDMAAVRRHQEVAEAVAAGRSAEAAQAVTAIVNAAHSEVQDLLAGGSCGYGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JZD3</accession>
    <name>A0A2M9JZD3_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Glyoxalase_6 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_14425</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN12231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN12231">
        <property type="protein sequence ID" value="PJN12231"/>
        <property type="gene ID" value="CG723_14425"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041581">
        <property type="entry name" value="Glyoxalase_6"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18029">
        <property type="entry name" value="Glyoxalase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glyoxalase_6" evidence="1">
        <location>
            <begin position="8"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF18029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN12231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="144" mass="15986" checksum="527AABAD4F346851" modified="2018-04-25" version="1">MSSIKKFQVTFDCADPERVARFWCEVLGYVVPPAPEGFATWDDYNRSLPPERQGSGFVCMDPSGVGPRMYFQRVPEGKVVKNRVHLDVRVGTGLVGEERLAALEAECARLVPLGAVRGQLLLADEYNESCLGMQDIEGNEFCLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JZI6</accession>
    <name>A0A2M9JZI6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CG723_04320</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000002">
        <property type="protein sequence ID" value="PJN12289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN12289">
        <property type="protein sequence ID" value="PJN12289"/>
        <property type="gene ID" value="CG723_04320"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PJN12289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="202" mass="22567" checksum="B07965056C501E74" modified="2018-04-25" version="1">MDRMSARRRPAPTGEPFTVTDFQLVLLRRMADHNADLVEDARRQLGATVAQMREANRRYQARRHVRGPLTTRSMYRSLLGAPEHTVTRHIGDLTCEALQWSVPLWPGLLFEALAGPNGAVWNEWLVRAPGAPAPALRTLDDLVPWSCTVDEVSEAFPPARPLEGSAPTRWGLAFTAPDTEGTPREVKAEFTYGLLQRWTLTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JZJ3</accession>
    <name>A0A2M9JZJ3_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Acetyl-coenzyme A carboxylase carboxyl transferase subunits beta/alpha</fullName>
            <ecNumber evidence="8">2.1.3.15</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">CG723_04305</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">CB01635</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="17">Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>acetyl-CoA + N(6)-carboxybiotinyl-L-lysyl-[protein] = malonyl-CoA + N(6)-biotinyl-L-lysyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:54728"/>
            <dbReference type="Rhea" id="RHEA-COMP:10505"/>
            <dbReference type="Rhea" id="RHEA-COMP:10506"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:57384"/>
            <dbReference type="ChEBI" id="CHEBI:83144"/>
            <dbReference type="ChEBI" id="CHEBI:83145"/>
            <dbReference type="EC" id="2.1.3.15"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">Lipid metabolism; malonyl-CoA biosynthesis; malonyl-CoA from acetyl-CoA: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Acetyl-CoA carboxylase is a heterotetramer composed of biotin carboxyl carrier protein (AccB), biotin carboxylase (AccC) and two subunits of ACCase subunit beta/alpha.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">In the C-terminal section; belongs to the AccA family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">In the N-terminal section; belongs to the AccD/PCCB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.3.15" evidence="8"/>
    <dbReference type="EMBL" id="NNBL01000002">
        <property type="protein sequence ID" value="PJN12286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN12286">
        <property type="protein sequence ID" value="PJN12286"/>
        <property type="gene ID" value="CG723_04305"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00655">
        <property type="reaction ID" value="UER00711"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009317">
        <property type="term" value="C:acetyl-CoA carboxylase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003989">
        <property type="term" value="F:acetyl-CoA carboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:2001295">
        <property type="term" value="P:malonyl-CoA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034733">
        <property type="entry name" value="AcCoA_carboxyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001095">
        <property type="entry name" value="Acetyl_CoA_COase_a_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000438">
        <property type="entry name" value="Acetyl_CoA_COase_Trfase_b_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011763">
        <property type="entry name" value="COA_CT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011762">
        <property type="entry name" value="COA_CT_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42853">
        <property type="entry name" value="PTHR42853"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01039">
        <property type="entry name" value="Carboxyl_trans"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01070">
        <property type="entry name" value="ACCCTRFRASEB"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50989">
        <property type="entry name" value="COA_CT_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50980">
        <property type="entry name" value="COA_CT_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="16" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="13" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="10" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="15" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="CoA carboxyltransferase N-terminal" evidence="18">
        <location>
            <begin position="1"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="domain" description="CoA carboxyltransferase C-terminal" evidence="19">
        <location>
            <begin position="239"/>
            <end position="450"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00006276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00010284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00011664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00011883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00018312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00025280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="PJN12286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="450" mass="45814" checksum="C05DAB6948E62E08" modified="2018-04-25" version="1">MADAVRLSAREALAAVTDPGTFTELPAPDGTYAPDGPLSWEGYDAARARATARTGEAESVVCGTASVGGTRAVLVSFEFGFLGGSLGERTGDRIEAAYAFARAHRLPVVPLVATGGSRMQEGMRALTQLQRVARQSALTREAGLAQVAVLRDPTTGGGWATLGAGADVILALDSAQVGFAGSRVRPADADPAAYSARGQFAAGAVDAVVRPDDLAGTLAGWLRLLTRPSDGPAPVPYALGRGDLPATGRDAVRRARAPERPRADAYLDAYFTSRVTVSGDRCGGTDDGVLCGFGEGARDGRTVAYAAQLGTATRPAGYRTAARLVRLAGRLGVPVLTLVDTPGAANDAEAERSGAGAAIADLFTALAASPVPVTTLVVGEGGSGGALALAAPENTWATPDSYFSVIAPELAAAILKRAPDETDATADQLHLRPQDLVELGVVRGIAGTAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JZL3</accession>
    <name>A0A2M9JZL3_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 7">Aldose 1-epimerase</fullName>
            <ecNumber evidence="4 7">5.1.3.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CG723_04490</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CB01635</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>alpha-D-glucose = beta-D-glucose</text>
            <dbReference type="Rhea" id="RHEA:10264"/>
            <dbReference type="ChEBI" id="CHEBI:15903"/>
            <dbReference type="ChEBI" id="CHEBI:17925"/>
            <dbReference type="EC" id="5.1.3.3"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 7">Carbohydrate metabolism; hexose metabolism.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the aldose epimerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.1.3.3" evidence="4 7"/>
    <dbReference type="EMBL" id="NNBL01000002">
        <property type="protein sequence ID" value="PJN12319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN12319">
        <property type="protein sequence ID" value="PJN12319"/>
        <property type="gene ID" value="CG723_04490"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00242"/>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004034">
        <property type="term" value="F:aldose 1-epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019318">
        <property type="term" value="P:hexose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018052">
        <property type="entry name" value="Ald1_epimerase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015443">
        <property type="entry name" value="Aldose_1-epimerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008183">
        <property type="entry name" value="Aldose_1/G6P_1-epimerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014718">
        <property type="entry name" value="GH-type_carb-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01263">
        <property type="entry name" value="Aldose_epim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005096">
        <property type="entry name" value="GALM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="SSF74650"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00545">
        <property type="entry name" value="ALDOSE_1_EPIMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="6 7" id="KW-0413">Isomerase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="10">
        <location>
            <begin position="78"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="10">
        <location>
            <begin position="174"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="8">
        <location>
            <position position="174"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="8">
        <location>
            <position position="294"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="234"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00014165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR005096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR005096-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR005096-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR005096-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PJN12319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="330" mass="35351" checksum="BB5C28B6DC42A169" modified="2018-04-25" version="1">MRSELFGTLPDGTPVHRWTLERGGVRVRVLTYGGIVQSAEVPDRGGATADVALGFPSLDGYLAHPGPFLGALVGRYANRIAGGRFPLDGRTYHLAQNNGTNALHGGERGFDKRVWDADPLEHGVRLHRVSPHGEEGFPGRMEVSATYTLDESGALRIVYEAVTDAPTVVNLTNHSYWNLGGAGSGDAAGGHEVRIAASRFTAADGDLIPTGEFTEVAGTAFDFREPRKPGLGHDRNYVLDKGVTEAPAEVAELHDPASGRTLTVATTEPGLQLYTGDHFDETLPFAPGAGIALETQHFPDSPNRPRFPSTQLRPGQVFRSETVYGFGTRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-06-02" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JZX1</accession>
    <name>A0A2M9JZX1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_05135</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000002">
        <property type="protein sequence ID" value="PJN12429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN12429">
        <property type="protein sequence ID" value="PJN12429"/>
        <property type="gene ID" value="CG723_05135"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="13"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN12429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="52" mass="5636" checksum="91FCD75756A0AD75" modified="2018-04-25" version="1">MAEMMNAEMTTTESREAADRSAGPGRHRGGVSSRDENAAPHGRHRKVQSEQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K007</accession>
    <name>A0A2M9K007_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NADPH-dependent F420 reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">npdG</name>
        <name evidence="2" type="ORF">CG723_05330</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000002">
        <property type="protein sequence ID" value="PJN12461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN12461">
        <property type="protein sequence ID" value="PJN12461"/>
        <property type="gene ID" value="CG723_05330"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070967">
        <property type="term" value="F:coenzyme F420 binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016651">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006740">
        <property type="term" value="P:NADPH regeneration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010185">
        <property type="entry name" value="NpdG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028939">
        <property type="entry name" value="P5C_Rdtase_cat_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03807">
        <property type="entry name" value="F420_oxidored"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01915">
        <property type="entry name" value="npdG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F420_oxidored" evidence="1">
        <location>
            <begin position="26"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN12461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="234" mass="24663" checksum="6CA161B35BB2DFFD" modified="2018-04-25" version="1">MTSTDSVQKAPAKDPWDLPDVSGLVVGVLGGTGDQGRGLAYRLARAGQKVIIGSRAAERAQAAADELGLGVEGADNAECARRCDIVIVAVPWEGHGKTLESLREDLAGKLVVDCVNPLGFDKKGAYALKPEEGSAAEQAAALLPDSRVTAAFHHLSAVLLQDEAIVEIDTDVMVLGEERADTEIVQALAGRIPGMRGVFAGRLRNAHQVESLVANLISVNRRYKAHAGLRVTDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-09-29" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K012</accession>
    <name>A0A2M9K012_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CG723_05380</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CB01635</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000002">
        <property type="protein sequence ID" value="PJN12471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN12471">
        <property type="protein sequence ID" value="PJN12471"/>
        <property type="gene ID" value="CG723_05380"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="42"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="70"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="100"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="133"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="158"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="200"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="232"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="267"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="292"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="331"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="358"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="4"/>
            <end position="385"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PJN12471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="419" mass="41774" checksum="2650155ED3F59FFB" modified="2018-04-25" version="1">MPLALLALAVGAFGIGTTEFVMMGLLPNVADDLHISIPSAGHLVSAYALGVVIGAPLLAALTARMPRRRVLVGLMVLFVAGNAVSAAAPDYHLLMAARFVSGLPHGAFFGVGAVVATSLVAPERKARSVSLMFLGLTVANVIGVPIATLMGQQLGWRATFLAVSAIGLAAITALLLLVPADHGHGESGGLRGELKALGSLPVWLSLGTTVAGFGALFAAYSYVTPMLTGTAGFAEASVTLLLALFGVGATAGNLLGGRLADRSLRGTLFGGLVSLVVVLALFPVLMRAEWSAGVAVVLLGMAAFTTGSPLQLMVMEKASAAPSLASSANQAAFNLANAGGAWIGGLALAAGFGLTSPAVAGAALAVLGIGVAGVAYGVDLRRSRGAAPSAATGHGLLVASHLPDAVSPAQDAGEPTRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K054</accession>
    <name>A0A2M9K054_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Acid phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_05465</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000002">
        <property type="protein sequence ID" value="PJN12484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN12484">
        <property type="protein sequence ID" value="PJN12484"/>
        <property type="gene ID" value="CG723_05465"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042578">
        <property type="term" value="F:phosphoric ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044003">
        <property type="term" value="P:modulation by symbiont of host process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007312">
        <property type="entry name" value="Phosphoesterase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31956">
        <property type="entry name" value="PTHR31956"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04185">
        <property type="entry name" value="Phosphoesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="SSF53649"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0843">Virulence</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014657311" evidence="2">
        <location>
            <begin position="40"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN12484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="295" mass="31063" checksum="8DEC0CF6ACA5E02C" modified="2018-04-25" version="1">MPGRSLFRRGRTAALASAFALTATAVALWSGVGGSSAQAAAGVPTPDHTVVVVFENHAYNQVIGSSSAPYINSLKTNGASLSASYALTHPSQPNYFALFSGATQGITDDSCYTPGFSSQPNLASELIAAGKTWGSYNEGLPSQGSTTCSSGDYARKHNPWFGFSNVPTSTAKTFAQFPSDYSTLPQVSFVVPDLCSDMHDCSVSTGDTWLKNNLSAYANWAKAHNSLLVVTFDEDNRLAGNKIPTVLYGQQVTPGATSATTYNHYDVLRTIEDMHGLPHAGNAASGKDITGIWAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K0J1</accession>
    <name>A0A2M9K0J1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Signal protein PDZ</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CG723_05810</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000002">
        <property type="protein sequence ID" value="PJN12547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN12547">
        <property type="protein sequence ID" value="PJN12547"/>
        <property type="gene ID" value="CG723_05810"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001940">
        <property type="entry name" value="Peptidase_S1C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13180">
        <property type="entry name" value="PDZ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00834">
        <property type="entry name" value="PROTEASES2C"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="SSF50156"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="SSF50494"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014876968" evidence="2">
        <location>
            <begin position="46"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="3">
        <location>
            <begin position="283"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="52"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="56"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PJN12547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="383" mass="38744" checksum="131C449BF24AB5B8" modified="2018-04-25" version="1">MDPFRARSRARSLSGSRTRARPTRSGRARVLRLALPLTAVVCSLALVGGCSGDDSAGPSDPSTKPSATTEQAALASGNALQADYQKVIKDVLPSVVQIQASSEQGSGIVYDDKGHVVTNAHVVGDEKTFKVTTSNSETELTATLVYAYPEQDLAVIKLDKVAEGLKPARFADSSKVEVGQITLAMGSPLGLSSSVTQGIVSATGRTVSENREAGGTGATIGNMVQTSAAINPGNSGGALVNLDGQVVGIPTLAATDPNMSGGAAPGIGFAIPSSMVSTVADQVIKKGKVTDSGRAALGITGRTVLGSSYQPDGVAVVDVDDGGAAQKAGIQSGDVITQVGDTDVNTMVSLAEELAADKPGDKVSVAYLRNGAAMTAEVTLGEM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K165</accession>
    <name>A0A2M9K165_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Aminotransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_07620</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000002">
        <property type="protein sequence ID" value="PJN12872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN12872">
        <property type="protein sequence ID" value="PJN12872"/>
        <property type="gene ID" value="CG723_07620"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044249">
        <property type="term" value="P:cellular biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000192">
        <property type="entry name" value="Aminotrans_V_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00266">
        <property type="entry name" value="Aminotran_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotran_5" evidence="1">
        <location>
            <begin position="19"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN12872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="350" mass="36401" checksum="EEE3E31093035894" modified="2018-04-25" version="1">METLDHALVRAEFAPVTSYLNTASTGLLPSRTVAAMKDAVASVAAGRPADMFADVEAARAAFARLAGVPADRVAAGASVAVYTGVIAASLPAGAEVLTAQDDFSSTVNPFYVRGDLKVRTAPLEGIADAVRPGTALVAVSAAQSADGRVADLPAIREAARAHGARTYIDCSQAAGWLPVDADAQDYTSTVGFKWLLCPRGVSFLVVPEDMGSLSAVFAGWVAGEHPWDSCYGPVEELAHSARRFDESPSLFSYAGARHSLALIEELGVDAIRAHDLALAERFRAGLATLGHEPVPAPGSPVVSVPGLGARQPELSRAGIEVSNRAGNLRAAFHLYNTDSDVDRLLEALSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K191</accession>
    <name>A0A2M9K191_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Cobalamin biosynthesis protein CobD</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">cobD</name>
        <name evidence="11" type="ORF">CG723_07730</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CB01635</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 10">Cofactor biosynthesis; adenosylcobalamin biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 10">Cell membrane</location>
            <topology evidence="2 10">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 10">Belongs to the CobD/CbiB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000002">
        <property type="protein sequence ID" value="PJN12889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN12889">
        <property type="protein sequence ID" value="PJN12889"/>
        <property type="gene ID" value="CG723_07730"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00148"/>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015420">
        <property type="term" value="F:ABC-type vitamin B12 transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048472">
        <property type="term" value="F:threonine-phosphate decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009236">
        <property type="term" value="P:cobalamin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00024">
        <property type="entry name" value="CobD_CbiB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004485">
        <property type="entry name" value="Cobalamin_biosynth_CobD/CbiB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34308">
        <property type="entry name" value="PTHR34308"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03186">
        <property type="entry name" value="CobD_Cbib"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00380">
        <property type="entry name" value="cobD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 10" id="KW-0169">Cobalamin biosynthesis</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 10" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PJN12889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="313" mass="31917" checksum="54A9D24FA6FDD2E3" modified="2018-04-25" version="1">MRAERVFAYGSAAGLLGDLLIGDPRRGHPVAAFGRAAGAVERVLWRDHRGWGAVHTAVCAGGAAVAGGLAARAVRHSPAVSIALTAAATWAVVGGTSLGREARAIGGALTAGDVDAARERLPHLCGRDPQALDADGIARAVVESVAENTSDAVVGALVWGAVAGIPGLVAFRAVNTLDAMVGHKSARYRRYGWASARLDDVAGWPGARLTGVLAAVAGGRPRGALTAWRADARLHPSPNAGVVEASFAGALGVRLGGTLSYGGRVEHRPVLNASGRAVETADVERAARLSRRVSWLALGVCVAGRALLQRGKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K1M4</accession>
    <name>A0A2M9K1M4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CG723_07870</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CB01635</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000002">
        <property type="protein sequence ID" value="PJN13031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN13031">
        <property type="protein sequence ID" value="PJN13031"/>
        <property type="gene ID" value="CG723_07870"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005384">
        <property type="term" value="F:manganese ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030026">
        <property type="term" value="P:cellular manganese ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008217">
        <property type="entry name" value="Ccc1_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31851">
        <property type="entry name" value="PTHR31851"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01988">
        <property type="entry name" value="VIT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="20"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="52"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="152"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="180"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="211"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PJN13031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="236" mass="24183" checksum="88BDAACA3AEA816A" modified="2018-04-25" version="1">MQDAPHEESHGGALGARLNWLRAAVLGANDGVVSTAGLVVGVAGATEDRSTLLTAGLAGLLAGSMSMAAGEYVSVSTQRDSEKAALAQEKRELREYPEAELVELTGLLEDRGLSPEVAREAAEQLTSRDALRAHARVELGIDPDDLTNPWHAAWASFLAFTVGALLPLLAIVLPPSAWRLPVTVVSVLAALALTGWSSARTGSAAVGPAVWRNMAGGALAMAVTYGAGSLLGAAGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K236</accession>
    <name>A0A2M9K236_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ABC transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CG723_00900</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000001">
        <property type="protein sequence ID" value="PJN13183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN13183">
        <property type="protein sequence ID" value="PJN13183"/>
        <property type="gene ID" value="CG723_00900"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="4"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="299"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="299"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="36"/>
            <end position="43"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PJN13183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="328" mass="35147" checksum="F1666872EA5070F5" modified="2018-04-25" version="1">MTAVAVEGLRKRYGDHEAVRGVDFTVSDGEIFALLGPNGAGKTTTLEILEGFRGRDGGSVEVLGRDPGKKADGKWLRGQIGLVLQDIAVEPYLSVRETIARNAGYYPAPRGIDEVIDLVGLDEKRGAKVKDLSGGQKRRLDLALGVVGNPQLLFLDEPTTGFDPNARRGAWEVVKNLRDAGTTIVLTTHYMDEAQALADSVAVIAGGEIVAAGTPDTLGGRDSALARIRFLLPHGAALTDVPLPVSDVHEGLVTAESDEPTAALHRLTEWALRRGTPLERLTVEQPTLEDIYLGLTSKYAEQEASSPSSERGRGPSSRRGRRPGRSRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K2B0</accession>
    <name>A0A2M9K2B0_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">GPW_gp25 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_01335</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000001">
        <property type="protein sequence ID" value="PJN13258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN13258">
        <property type="protein sequence ID" value="PJN13258"/>
        <property type="gene ID" value="CG723_01335"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007048">
        <property type="entry name" value="IraD/Gp25-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04965">
        <property type="entry name" value="GPW_gp25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GPW_gp25" evidence="1">
        <location>
            <begin position="33"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN13258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="130" mass="14354" checksum="372FD4B0D0C71FF8" modified="2018-04-25" version="1">MSQTSRGTRPRSDIAFPFRTDRRGRTAHAGHGEHVHDLIEQLLFTSPGERAMRPDFGCGLLDLVFAPNTPELVSTLELSVQASLQRWLGDLIDVVALDVESADDAVRVYLSYVLRATGTRTDDVFEGRAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K2L8</accession>
    <name>A0A2M9K2L8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Immediate-early protein 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CG723_01980</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000001">
        <property type="protein sequence ID" value="PJN13371.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN13371">
        <property type="protein sequence ID" value="PJN13371"/>
        <property type="gene ID" value="CG723_01980"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PJN13371.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="146" mass="16436" checksum="AB62B6EA4C1C5080" modified="2018-04-25" version="1">MAFFRITRESPLSAAEAWRRMTDWERHGDVVPLTRVRLATPPPTGEGTVFVPRTGVGRHTFDDPMEVVDWAPPYGDSAGRCRLEKRGTFVTGWAEIEVAPYGAGSLVAWREEIRVRPLPRWCDPLLARAGRLMFGRAVKKLLQYGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K2S5</accession>
    <name>A0A2M9K2S5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">4-diphosphocytidyl-2C-methyl-D-erythritol synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_02280</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000001">
        <property type="protein sequence ID" value="PJN13423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN13423">
        <property type="protein sequence ID" value="PJN13423"/>
        <property type="gene ID" value="CG723_02280"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025877">
        <property type="entry name" value="MobA-like_NTP_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12804">
        <property type="entry name" value="NTP_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NTP_transf_3" evidence="1">
        <location>
            <begin position="12"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN13423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="201" mass="20509" checksum="BF51880E43A74839" modified="2018-04-25" version="1">MTHATDDAPVTGLLLAAGGGRRLGGRPKALLTHRGRPLVEHAVAVLRAGGCERVHVVLGAAADDVRARADLAGCVLVENPAWEEGMGSSLRAGLGSLTGTGASAALVLLVDQPGIGAPAVARVRAAYRSAGSLAAAAYDGERGHPVLFGAEHWPGIVASAAGDRGARAYLKEHASELTLVECGDVADDYDIDTEADLKHLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K2T7</accession>
    <name>A0A2M9K2T7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_02380</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000001">
        <property type="protein sequence ID" value="PJN13438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN13438">
        <property type="protein sequence ID" value="PJN13438"/>
        <property type="gene ID" value="CG723_02380"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004104">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02894">
        <property type="entry name" value="GFO_IDH_MocA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GFO_IDH_MocA" evidence="1">
        <location>
            <begin position="1"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="domain" description="GFO_IDH_MocA_C" evidence="2">
        <location>
            <begin position="130"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN13438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="334" mass="35644" checksum="3705758D963E6A64" modified="2018-04-25" version="1">MRIGLIGTGRIGTFHAAVLERYREVGSLVVTDADPERAVALADRIGATAAPTVDEIFSWGVDAVVITAATSAHGDLIGRAARAGLPVFCEKPIALDLPGTLAALDEVERAGTVLQLGFQRRFDAGYTAAREAVRSGRLGRLHTVRAMTSDPAPPPAAYLPLSGGLYRDCLVHDFDILRWVTGREVTEVYATGSDAGPAMFREAGDVDTAAAVLTLDDGALVTATATRCNGAGYDVRMELSGERDTVVVGLDDRTPFASTEPKGPSAATKPWPGFLERFAPAYEAELVAFVDVVRGERENPCDGREALHALRIAEACELSRRERRLVRMEEIPGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K345</accession>
    <name>A0A2M9K345_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Fe-S-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CG723_03045</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CB01635</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000001">
        <property type="protein sequence ID" value="PJN13551.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN13551">
        <property type="protein sequence ID" value="PJN13551"/>
        <property type="gene ID" value="CG723_03045"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00207">
        <property type="entry name" value="fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036010">
        <property type="entry name" value="2Fe-2S_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001041">
        <property type="entry name" value="2Fe-2S_ferredoxin-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006963">
        <property type="entry name" value="Mopterin_OxRdtase_4Fe-4S_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027467">
        <property type="entry name" value="MopterinOxRdtase_cofactor_BS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00037">
        <property type="entry name" value="Fer4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04879">
        <property type="entry name" value="Molybdop_Fe4S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00926">
        <property type="entry name" value="Molybdop_Fe4S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54292">
        <property type="entry name" value="SSF54292"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51085">
        <property type="entry name" value="2FE2S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51669">
        <property type="entry name" value="4FE4S_MOW_BIS_MGD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00551">
        <property type="entry name" value="MOLYBDOPTERIN_PROK_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="4 6" id="KW-0408">Iron</keyword>
    <keyword evidence="5 6" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="2Fe-2S ferredoxin-type" evidence="7">
        <location>
            <begin position="11"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="8">
        <location>
            <begin position="143"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="8">
        <location>
            <begin position="188"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S Mo/W bis-MGD-type" evidence="9">
        <location>
            <begin position="230"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="237"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="240"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="244"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="272"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PJN13551.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="286" mass="31408" checksum="8B4864272C4454D9" modified="2018-04-25" version="1">MTAIPLGVPRRLVEFTLDGQEARVPEGSTILDACRAAGKDIPTLCEGDTLTPKNACRVCVVEVEGARTLAPACSRKAEAGMEVRTDTERARHSRKVVLELLASSVNLSTTPRAAEWIKEYEAKPDRFGPDAARVDEEPRVDNDLYVRDYDKCILCYKCVDACGDQWQNTFAISVVGRGFDARIAVEHDAPLTDSACVYCGNCIEVCPTGALSFKSEFDMRAAGTWNEEEQTETTTVCAYCGVGCNLTLHVQDNEIVKVTSPHDNPVTHGNLCIKGRFGYQHVQNRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K365</accession>
    <name>A0A2M9K365_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Amidohydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_02865</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000001">
        <property type="protein sequence ID" value="PJN13520.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN13520">
        <property type="protein sequence ID" value="PJN13520"/>
        <property type="gene ID" value="CG723_02865"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01979">
        <property type="entry name" value="Amidohydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="SSF51338"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014864074" evidence="1">
        <location>
            <begin position="41"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="domain" description="Amidohydro-rel" evidence="2">
        <location>
            <begin position="113"/>
            <end position="429"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN13520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="432" mass="44661" checksum="6D191EC88D7367C8" modified="2018-04-25" version="1">MCVENCPPPSNRLTRRGVLAGAAALAGTTAALAAAPGASAAAPMTRASATRSGIAPRGGDLVIDGGTLLDPATGDVTEDSVVVIRDGVVRAAGPRARVDVPKGATVLDAHGQWVLPGLVDSHIHLNTAAEAAKTLALGATTARSGSTNFYQDIAVRELSRQAPGLAPRLRASGVFVTPDLGDTILADPDLTPLARLKGGVTSTEALRRVVEVNLARGVDTVKTRVNPRAGLAEQDPLEQVYSREQLSTIVATARRGGKDVLCHSYSEKGCHDAVMAGVKSVEHGAFISERTLHEMRRRDTYFTPTMVAIGGMIGDPDPILDERGRTYLPKLKAAAKLAHELGVGLVSGTDSSGGSVEPIGAEIEMMHSAGLSALDAIRTATTNAARLLGFEGQVGRLARGYAGDAILLSGNPLADVSVLKKPVRVVRAGVAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K3H5</accession>
    <name>A0A2M9K3H5_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase (flavodoxin)</fullName>
            <ecNumber evidence="4">1.17.7.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">ispG</name>
        <name evidence="5" type="ORF">CG723_03785</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CB01635</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>(2E)-4-hydroxy-3-methylbut-2-enyl diphosphate + 2 H(+) + H2O + oxidized [flavodoxin] = 2-C-methyl-D-erythritol 2,4-cyclic diphosphate + reduced [flavodoxin]</text>
            <dbReference type="Rhea" id="RHEA:43604"/>
            <dbReference type="Rhea" id="RHEA-COMP:10622"/>
            <dbReference type="Rhea" id="RHEA-COMP:10623"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57618"/>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
            <dbReference type="ChEBI" id="CHEBI:58483"/>
            <dbReference type="ChEBI" id="CHEBI:128753"/>
            <dbReference type="EC" id="1.17.7.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="4">Binds 1 [4Fe-4S] cluster.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4">Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via DXP pathway; isopentenyl diphosphate from 1-deoxy-D-xylulose 5-phosphate: step 5/6.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the IspG family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.17.7.3" evidence="4"/>
    <dbReference type="EMBL" id="NNBL01000001">
        <property type="protein sequence ID" value="PJN13675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN13675">
        <property type="protein sequence ID" value="PJN13675"/>
        <property type="gene ID" value="CG723_03785"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00056">
        <property type="reaction ID" value="UER00096"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046429">
        <property type="term" value="F:4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019288">
        <property type="term" value="P:isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016114">
        <property type="term" value="P:terpenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.413.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00159">
        <property type="entry name" value="IspG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011005">
        <property type="entry name" value="Dihydropteroate_synth-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016425">
        <property type="entry name" value="IspG_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004588">
        <property type="entry name" value="IspG_bac-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045854">
        <property type="entry name" value="NO2/SO3_Rdtase_4Fe4S_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30454">
        <property type="entry name" value="PTHR30454"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04551">
        <property type="entry name" value="GcpE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004640">
        <property type="entry name" value="IspG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51717">
        <property type="entry name" value="SSF51717"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56014">
        <property type="entry name" value="SSF56014"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00612">
        <property type="entry name" value="ispG_gcpE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="3 4" id="KW-0414">Isoprene biosynthesis</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="4">
        <location>
            <position position="284"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="287"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="319"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="326"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PJN13675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="388" mass="40573" checksum="4896B28230431CC9" modified="2018-04-25" version="1">MTSGEPVSLGLPSLPVRPIADRRTSRQIHVGPVAVGGGAPVSVQSMTTTRTSDIGATLQQIAELTASGCQIVRVACPTQDDADALATIARKSQIPVIADIHFQPKYVFAAIEAGCAAVRVNPGNIKQFDDKVKEIAQAAKDHGTPIRIGVNAGSLDARLLKKYGKATPEALVESALWEASLFEEHGFSDIKISVKHNDPVVMVNAYRQLAAASDYPLHLGVTEAGPAFQGTIKSAVAFGALLSEGIGDTIRVSLSAPPVEEIKVGIQILESLGLRERRLEIVSCPSCGRAQVDVYKLADEVSAGLDGMEVPLRVAVMGCVVNGPGEAREADLGVASGNGKGQIFVKGEVIKTVPESKIVETLIEEAMKIAEQMTDAGVASGAPDVTVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K3Q5</accession>
    <name>A0A2M9K3Q5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">OHCU decarboxylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">uraD</name>
        <name evidence="4" type="ORF">CG723_02140</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000001">
        <property type="protein sequence ID" value="PJN13761.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN13761">
        <property type="protein sequence ID" value="PJN13761"/>
        <property type="gene ID" value="CG723_02140"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006144">
        <property type="term" value="P:purine nucleobase metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3330.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018020">
        <property type="entry name" value="OHCU_decarboxylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017595">
        <property type="entry name" value="OHCU_decarboxylase-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036778">
        <property type="entry name" value="OHCU_decarboxylase_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09349">
        <property type="entry name" value="OHCU_decarbox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158694">
        <property type="entry name" value="SSF158694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03180">
        <property type="entry name" value="UraD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0659">Purine metabolism</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OHCU_decarbox" evidence="3">
        <location>
            <begin position="33"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="90"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF09349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PJN13761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="196" mass="21439" checksum="D4EA8D2EDEC679B5" modified="2018-04-25" version="1">MFRRALAIRSPSSSRPRRLPVTSRPMPGLSRFNTLQENAAGAALHEVCASSAWGSKLLAQRPFESAEELFDASDAAMAELSAEDLAEAMAGHPPIGRPKPGDPTSSREQRGMAGASEELKAEMLELNLAYQDRFGHVFLICATGATGEQMRDAMKARIGNDTGTEREIVRTELGKINRIRLTRLAEEDVEVEEDKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JEL6</accession>
    <name>A0A2M9JEL6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">TetR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CG723_45415</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000054">
        <property type="protein sequence ID" value="PJN05319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN05319">
        <property type="protein sequence ID" value="PJN05319"/>
        <property type="gene ID" value="CG723_45415"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039538">
        <property type="entry name" value="BetI_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13977">
        <property type="entry name" value="TetR_C_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0678">Repressor</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="3">
        <location>
            <begin position="9"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="2">
        <location>
            <begin position="32"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PJN05319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="197" mass="21919" checksum="34D67217D7723921" modified="2018-04-25" version="1">MAKGAQTRARSVSRLQAAALEVFAERGFHGASIEEICTRAGLSRGAFYSNFEDKEALFFALFDEHADREVARLDAAISDASTVEEALDGLTGDGSGDEERLWFLASTEFTLHAIRNPQTAERLAEHDRRLRARLTELLTGFFARVGRHGNLDLDPLARLLIALHEGALMQSLIEPDRLPPGELQRRFLPAILRAEDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-09-29" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JEV1</accession>
    <name>A0A2M9JEV1_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">PepX_C domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CG723_45020</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000049">
        <property type="protein sequence ID" value="PJN05425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN05425">
        <property type="protein sequence ID" value="PJN05425"/>
        <property type="gene ID" value="CG723_45020"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008239">
        <property type="term" value="F:dipeptidyl-peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005674">
        <property type="entry name" value="CocE/Ser_esterase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000383">
        <property type="entry name" value="Xaa-Pro-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013736">
        <property type="entry name" value="Xaa-Pro_dipept_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02129">
        <property type="entry name" value="Peptidase_S15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08530">
        <property type="entry name" value="PepX_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00939">
        <property type="entry name" value="PepX_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="SSF49785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00976">
        <property type="entry name" value="NonD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014683307" description="PepX_C domain-containing protein" evidence="2">
        <location>
            <begin position="29"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="domain" description="PepX_C" evidence="3">
        <location>
            <begin position="363"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="411"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="411"/>
            <end position="428"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PJN05425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="586" mass="63585" checksum="A5016A624DEC40F2" modified="2018-04-25" version="1">MRKRPAATAAALLTACALTCGLIGAAVAAPDQATDGGRTGRTTVATATDSVTHEENERVPEGARWTQHYFPSSDGSKTELHADVLLPEKLPEGAKVPVIMSAGAYFGHSGEMEVEEEHAGPSERFQDLLEGTDLFDKGYAFVMVDTRGFGGSTGCLDLGGPGDQADVKAAIDWSAKQPWSTGSVGMYGKSFDAYTGLLGNNVKHDALKAVVAQEPIWDLYQQLHSNGVPRPNSVQLPTSYNRIAGLAQLTDENKRYRTNAAYEKKHPECLVLNSFGPSIGDPDDPYWKDRSPARNAKGTATPLLFTQGTAETNTLPVGMEEFLDNHRGPQRAWIGPWGHVRGNERTQDGKLAMGRANWFKETLSFFDEHLKGIDPKIQDPNYAVQDNLGNWRAEKSWPTANRSANLRLGNGSYVDSGAGSQPTSPEEESGRDAGSFLVWSGPLETATRVTGTPRITMTAKGEGNVMVKLYDVDEDGNAVAFDERVSRLDRDRLDIGLKSTDWTLRAGHRLAVEIGSVRTGDWLDTPSKQNIRISSARLQLPLDNPAEDIATGGDRAPWLDTFTQINAAQLKPGPATFTVPPARARR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JEZ3</accession>
    <name>A0A2M9JEZ3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CG723_45230</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000051">
        <property type="protein sequence ID" value="PJN05373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN05373">
        <property type="protein sequence ID" value="PJN05373"/>
        <property type="gene ID" value="CG723_45230"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PJN05373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="62" mass="6575" checksum="D004F9A93A1AAC3B" modified="2018-04-25" version="1">MRECTGVEGGQLRDEYRHALEQLVEAKVTGGELAAPPEPGPAVDLMAALEESVRAARARQSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JEZ8</accession>
    <name>A0A2M9JEZ8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_45465</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000054">
        <property type="protein sequence ID" value="PJN05327.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN05327">
        <property type="protein sequence ID" value="PJN05327"/>
        <property type="gene ID" value="CG723_45465"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025161">
        <property type="entry name" value="Put_IS4/IS5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13340">
        <property type="entry name" value="DUF4096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN05327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="156" mass="17763" checksum="9ABD21D3E0ECE1BA" modified="2018-04-25" version="1">MRRRRSLSSRSQAASVRSSITLAGCPDRSPDSSECTRWRGSPPRPPLTHHQLTTFAMTPLTRPDSETLLEYWGVSFGSSDRWSDVSLADAQWARIEPLLPDRTPKRGGRWRDHRQVIDAITWKFRTGSPRDSKRPASAQLALSVDAWRQFTEFAAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JF21</accession>
    <name>A0A2M9JF21_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CG723_44775</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000048">
        <property type="protein sequence ID" value="PJN05474.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN05474">
        <property type="protein sequence ID" value="PJN05474"/>
        <property type="gene ID" value="CG723_44775"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PJN05474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="180" mass="19352" checksum="5441C2FB5240C72C" modified="2018-04-25" version="1">MPGMSPTAELAQWTLSARGFRGFVPFRALPGSNVPTGHGIYVVIRTDTSPPSFLPTSPAGHLKGRDPSVTADKLGDAWVDGATVVYIGKAAGQDGLNQRLADYRRHGTGLMAGHWGGRYIWQLADSDTLLVAWLPMTEDDPGEAEQDLIDEFKRLHGGALPFANLRNNARKAPGTDTSID</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JFS7</accession>
    <name>A0A2M9JFS7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">ABC transporter substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CG723_43240</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000042">
        <property type="protein sequence ID" value="PJN05750.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN05750">
        <property type="protein sequence ID" value="PJN05750"/>
        <property type="gene ID" value="CG723_43240"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042597">
        <property type="term" value="C:periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030678">
        <property type="entry name" value="Peptide/Ni-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039424">
        <property type="entry name" value="SBP_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000914">
        <property type="entry name" value="SBP_5_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30290">
        <property type="entry name" value="PTHR30290"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00496">
        <property type="entry name" value="SBP_bac_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002741">
        <property type="entry name" value="MppA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014876954" evidence="2">
        <location>
            <begin position="19"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="domain" description="SBP_bac_5" evidence="3">
        <location>
            <begin position="89"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="20"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="27"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PJN05750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="559" mass="61206" checksum="A630CDA454794CEC" modified="2018-04-25" version="1">MLAAAVIGALAVTATACSETKHKGDSDGNNATQSSGPKKKGGTVTIANTAGQTWTCNFNPFNPAVYNTSIGFVYEPLIYVNTLKDAAETPMLAKSYKWNADKTQIDFTVRSGVKWNDGKPFTAKDVAFTFNLMKRVPSTDLYALWTTAGLQSATASGDKVTLKFEKAAQPYFYAFAHQVAIVPEHVFGTGAAAAHPDTWVDKKPVGTGPFEVNPCSPNNIQYTANPGYWQPGKPYIQKVEYPAYLDNGPANLDLANGKAQWGSQFIPGIKQFYLDKSADNHTWSPPVLNVSIHPNLDPSHKMTSNLKVRQAISLAIDRDKVSKIGVGGQEPAANQSGIVTPTFDKYYDKAAVEKAGFDKPDPARAKKLLGELGYSPSKPLKLKIITITGYTDWDASLNVIKQNLKAVGIDLAVQDLAQQTMIGHLYTGDYDLAYYAQQTSGPTPYYELRQMLHSANTAPLGKNAASNWERYKNPKVDQLLNDYASANETKQVEIVKQVAQYMIDDVPVIPIVESVDWFQYNTKDIAGWPTEDNPYAQPAAYNFPDTGQVLTHLYSKSAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JFV2</accession>
    <name>A0A2M9JFV2_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">CYSTM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CG723_42750</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CB01635</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000041">
        <property type="protein sequence ID" value="PJN05759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN05759">
        <property type="protein sequence ID" value="PJN05759"/>
        <property type="gene ID" value="CG723_42750"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028144">
        <property type="entry name" value="CYSTM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043740">
        <property type="entry name" value="DUF5685"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12734">
        <property type="entry name" value="CYSTM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18937">
        <property type="entry name" value="DUF5685"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="CYSTM" evidence="6">
        <location>
            <begin position="367"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="287"/>
            <end position="374"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF12734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PJN05759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="445" mass="45274" checksum="CE7D7CDC4134F136" modified="2018-04-25" version="1">MFGIVRPCSHRLGEGLKAQWMAHLCGLCLALRGDHGQFARIVTNYDGLLISVLTEAQAEHAAGGRRTAGPCPLRGMRTASVAQGEGARLAAAVSLVLASAKVRDHVADGDGLLARRPVAAAARRVATKWGKAGSRTGSDVGFDTAVLVDAVERQIGIESLAGLGTPVLTVTEPTETATAAAFAHTAVLAGRPGNAAPLAEAGRLFGRLAHLLDAVEDKEADAASDAWNPLTATGTDLTEARRLADDALRGIRLALREAEFVDGTLAHLLLVHELRRSVDRAFGTSGCAHGADASHGADPSHGAGPSHGAHAPTASSPQQGPGAPGPWVPTGSGPYVPPGSSGPYGSQNPYGGGRGGPGGPGGPGGFGGGPSFQPPKPGKRGFFAGCAAAIGLCCTCKVCCADEFEGPWSRKKRDGWCSDCCSTDCSCCEACSICECCECCSCCDC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JG99</accession>
    <name>A0A2M9JG99_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CG723_41995</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000038">
        <property type="protein sequence ID" value="PJN05909.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN05909">
        <property type="protein sequence ID" value="PJN05909"/>
        <property type="gene ID" value="CG723_41995"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="6"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="38"/>
            <end position="45"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PJN05909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="320" mass="34424" checksum="DD48F2759AC7F48C" modified="2018-04-25" version="1">MTDLAIAANGLRKSYGDKTVLDGIDLHIPTGTVFALLGPNGAGKTTAVKILSTLISPDPASGELRVGGHDLATDAHAARAAIGVTGQFSAVDALITGEENMLLMADLHHLSKREGRRVAAELLERFDLTDAASKPASTYSGGMKRRLDIAMTLVGNPRIIFLDEPTTGLDPRSRHTMWGIIRELVSDGVTVFLTTQYLDEADELADRIAVLNDGKIAAEGTAEELKRLIPGGHIRLRFTDPDAYQNATLSLRDAGRDDESLSLLIPSDGSQRDLRSILDRLDTAGIQADELTVHTPDLDDVFFALTGNARIPNQPKETVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-09-29" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JGB4</accession>
    <name>A0A2M9JGB4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CG723_42110</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CB01635</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000038">
        <property type="protein sequence ID" value="PJN05926.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN05926">
        <property type="protein sequence ID" value="PJN05926"/>
        <property type="gene ID" value="CG723_42110"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004638">
        <property type="entry name" value="EmrB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00711">
        <property type="entry name" value="efflux_EmrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="17"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="57"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="84"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="110"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="144"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="170"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="206"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="236"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="274"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="313"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="340"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="366"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="413"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="474"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="19"/>
            <end position="454"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PJN05926.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="514" mass="51843" checksum="D303E059A3D8FC12" modified="2018-04-25" version="1">MHSTQPEVSAERDPRRWVILGVICLAQLVVLLDNTVLNVAIPVLTEDLGASTADVQWMVNAYALVQSGLLLTAGSFADRYGRKLMLLTGLVLFGLGSTAAALAQSSGQLIAARAGMGIGGALLATTTLAVIMQVFDDEERPRAIGLWGAVSSLGFAAGPLIGGALLDHFWWGSIFLINIPVALFGLLAAARLIPETKNPQGERPDFLGAVLSTLGMVGVVYAIISGPQYGWASPRVLVPAVVGVLALFAFVRWELRVSHPMLDMSFFRSRRFNGAIAGGLLVALGMAGSLFLLTQHLQLVLGYDALQAGLRTAPLALTIVALNLAGIGAKLLAKLGAARSIALGMSLLAVGLAAVALLGSGSDAGYGGMLVGLVVMGCGIALAMPAMAISIMSAIPPAKAGVGAGVQGTLTEFGGGLGVAVLGAILGSRFAALLPVGVGASGSLAAALTDAGDDPQVIKQVHDAFGDAVSTSQLIGAAAVFAGGLLAGCLLHLADRSAAAATAPADPVEAPAAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JGD3</accession>
    <name>A0A2M9JGD3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Threonine aldolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CG723_41630</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CB01635</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000037">
        <property type="protein sequence ID" value="PJN05950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN05950">
        <property type="protein sequence ID" value="PJN05950"/>
        <property type="gene ID" value="CG723_41630"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006520">
        <property type="term" value="P:cellular amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044249">
        <property type="term" value="P:cellular biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001597">
        <property type="entry name" value="ArAA_b-elim_lyase/Thr_aldolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01212">
        <property type="entry name" value="Beta_elim_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Beta_elim_lyase" evidence="4">
        <location>
            <begin position="19"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PJN05950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="356" mass="39117" checksum="D703C87B21A50F8B" modified="2018-04-25" version="1">MNPPKTDARRHHDPDVRGFASDNYAGAHPEILAALALANGGHQIAYGEDDYTANLQQIIRAHFGPTAEAFPVFNGTGANVVALQAVTDRWGAVICAESAHINVDEGGAPERMGGLKLLTVPTPDGKLTPELIDRQAFGWDDEHRAMPQVVSITQNTELGTLYTPDEIRAICDHAHERGMKVHLDGSRIANAAASLDVPMRTFTNAVGVDILSLGGTKNGALFGEAVVVLNQDAVSHMKHLRKLSMQLASKMRFVSVQLEALLAKDLWLRNARHANEMAQRLAEGVRAVHGVEILYPVQANAVFARLPHDVSERLQKRFRFYFWDEAAGDVRWMCAFDTREEDVDGFVAALKEEMAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JGH1</accession>
    <name>A0A2M9JGH1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">4-amino-4-deoxyprephenate dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_42145</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000038">
        <property type="protein sequence ID" value="PJN05932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN05932">
        <property type="protein sequence ID" value="PJN05932"/>
        <property type="gene ID" value="CG723_42145"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008977">
        <property type="term" value="F:prephenate dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004665">
        <property type="term" value="F:prephenate dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006571">
        <property type="term" value="P:tyrosine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003099">
        <property type="entry name" value="Prephen_DH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02153">
        <property type="entry name" value="PDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="SSF48179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51176">
        <property type="entry name" value="PDH_ADH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Prephenate/arogenate dehydrogenase" evidence="1">
        <location>
            <begin position="2"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN05932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="288" mass="29472" checksum="42964D8A9FBA0A4C" modified="2018-04-25" version="1">MFEHCVVAGGTGEVGRMFAGRLAGSGAQVLCLDPAASAPAALADDIRAPGPEAARAIAAADLVLLAVPEPVALDAIGPVTRLMRADALFADTLSVKGGIAERLHALAPGIQAVGLNPMFAPSLPLPGRPVAAATVTDGPAVRAFLALISGWGARVVEMSAQEHDALTAAQQAATHAAVLAFGLALGELGADIGALRATAPPPHRTLLQLLARISSGTPEVYWDVQSGNPHAQAARRAVGHGLERLGRAVASGDPSAFETLFQELRATLGERHRTELADACAELFAQLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JGN6</accession>
    <name>A0A2M9JGN6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NUDIX hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_41350</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000036">
        <property type="protein sequence ID" value="PJN06050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN06050">
        <property type="protein sequence ID" value="PJN06050"/>
        <property type="gene ID" value="CG723_41350"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="SSF55811"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN06050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="147" mass="15798" checksum="0808D9475A344913" modified="2018-04-25" version="1">MYGIVFHPVSGAVVVQDDEGRYNLPGGTPEPEDNADLVATLRREVHEESQLVLSDWAPVGYQLVREDGQAPYVQVRYAALLDKADPITPDPCTGRAYGRVLVSPADAAELLRWGERGAAQLAAASRVAAERWGLTIAAAGTARQELS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JGT2</accession>
    <name>A0A2M9JGT2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Type I-E CRISPR-associated protein Cse1/CasA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">casA</name>
        <name evidence="2" type="ORF">CG723_40815</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000035">
        <property type="protein sequence ID" value="PJN06094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN06094">
        <property type="protein sequence ID" value="PJN06094"/>
        <property type="gene ID" value="CG723_40815"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013381">
        <property type="entry name" value="CRISPR-assoc_prot_Cse1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09481">
        <property type="entry name" value="CRISPR_Cse1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02547">
        <property type="entry name" value="casA_cse1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="283"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="292"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN06094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="506" mass="56508" checksum="EE5F236BBEA03BF5" modified="2018-04-25" version="1">MATQPSILVRTRTGEELLGLHSVLLNAHAIETLAVPIPPAASGLWRLLAAITARITSLDQPDTPLEAWLKRRAELLETPTGFDPDIIDTYCAAHTWDLFDRTRPFLQDPALASQCAKTSGINTLVWGRPAGNNLAWFSAHTDTRPQPAPSHEAFWHLLIHHYYGRSGTCSTRTLTPPAPKHLQLRAGPVRGTVSFHPVGRTLYESLLLHLVPYQGSGQLADTDRCPWEEAPPDPHTPPTEVTWPGRLLAGRSRHALLLVPDRDGSHVTDVYLSFASRHIPPPAADPYTIIHTNRDKSADKRDTPRRADADRAMWRDLDALLLTDDETTNTHTSTRRPAAFDHLNDLPAPVRTHLRVQVHGFDQDPKTKDRTWYSALTPPIWNWAQEHDPDTATRIAECRRAAETLAATLRSTANQAWKQTTNAPRARPCTWSRTALALYWPRAEPLFWHLIEDREPDAFTAFAHLAITALRTATRTDLLHHQGAGPALAQAVAKLRATQSDRSKDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JHB7</accession>
    <name>A0A2M9JHB7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CG723_40485</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000034">
        <property type="protein sequence ID" value="PJN06157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN06157">
        <property type="protein sequence ID" value="PJN06157"/>
        <property type="gene ID" value="CG723_40485"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008775">
        <property type="entry name" value="Phytyl_CoA_dOase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05721">
        <property type="entry name" value="PhyH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PJN06157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="270" mass="29802" checksum="37F98FDEE05BA7D0" modified="2018-04-25" version="1">MTYTVPADLYRADRLAPLLDSINDIGAAETDVYRGLGFLAVRGLLTDREVRGVLDGLAVVARPSSPARVEFEEWAHPEQRNRDELLDGVRKLQHFCAHEPRLAELARHPAILATVARFLEAEPVLIQDMALLKPPGGGREKPWHQDKAFFDIPLGTPVVGVWIALDEATIDNGCMHVLPCTHTEGPVVHFARRDFQICDTEVQTHRDTAVPLPPGGALFFDGLLHHGTPPNLTDTRRRAVQLHYVPAGTVRTPQKDRLEAFGADGKDATC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JHM8</accession>
    <name>A0A2M9JHM8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Type IV secretion protein Rhs</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_39510</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000031">
        <property type="protein sequence ID" value="PJN06353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN06353">
        <property type="protein sequence ID" value="PJN06353"/>
        <property type="gene ID" value="CG723_39510"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045351">
        <property type="entry name" value="DUF6531"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001826">
        <property type="entry name" value="RHS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022385">
        <property type="entry name" value="Rhs_assc_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031325">
        <property type="entry name" value="RHS_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006530">
        <property type="entry name" value="YD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20148">
        <property type="entry name" value="DUF6531"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03527">
        <property type="entry name" value="RHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05593">
        <property type="entry name" value="RHS_repeat"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03696">
        <property type="entry name" value="Rhs_assc_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01643">
        <property type="entry name" value="YD_repeat_2x"/>
        <property type="match status" value="12"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6531" evidence="2">
        <location>
            <begin position="423"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="235"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="387"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1427"/>
            <end position="1474"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="387"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1451"/>
            <end position="1473"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN06353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="1592" mass="173495" checksum="D890E7B3EBC984E5" modified="2018-04-25" version="1">MGLGDIVDGVKGGINKGLSVGEDLIDEGKKKVGEGVDYATNKVGDGLDHVGLHGAADAVEDWGDDVASDLGATPGEQQLGQTEEANELVHGNPDKIREAAKHLKDFHTAFDHVSQGMKKVDSSGWAGEGGDAFRKKFGVHPTKWAQASDACDKAAGALDAYADTVKWAQGKAKDAVELYKKGQQASKDAVDAYNKKVDAYNAKIKANEDPGAKPEPFQDPGKADIKKAHETLTEARKQRNTAASDAQGKVKAALAHAPAEPPPLDRLGNTVVDGYKAYNTELTHVVGGALKGTAGLLNFARGLNPTDPYNLTHPAAYMQNVSMTLSGLVSTAAHPERIVTAAVDGFKKDPSEFVGRLIPELIGTKGAGLARSGLRLGLRTGAKDVAENAARRTVRDSERAAGHADGPNQHGRTENSVENKGSDPIDMATGRMYLPQTDVVLPGTLPLVFTRRVESGYRLGKWFGPSWSSTVDQRLEIDGEGVVFVTEDGLLLSYPHPAPGVPVLPTHGPAWPLDRVDGGYTVTDRRTGRVRHFADRAEGLAVLEQIDDRNGNWLTFEYDAQGTPLGIVASGGYHLELTTADGRVTALRLAGPSGAAHAVKAYGYDAAGHLGEVLNSSGSALRFTYDERGRVTSWTDSNDRSYTYAYDEQDRCVSERGSEGHMNLRLSYGEADPATGHRVTTTTTGEGHTRRFLVNSASQIVAETDPLGHTTRFTRDHRNRLLTAVDPLGHTVDRRYDDDGNPVLVRRPDGRETHAEYDASGRLTRLKGPDGATHRYAYDERGNRISATGPSGRTTHYAYDEAGHLTAVTDPLGHVTRVRCDRAGLAVEITDALGGVTRYGRDAFGRPTALTDPTGATTRLEWSVEGRLTRRVRPDGTAESWTYDGEGNCVTHTDPLGGVTRHEYTHFDLLTARTSPDGVRHEFEHDDELRLTKVTNPQGLTWSYVYDPAGRLTSETDFDGRTLSYAHDAASRLVARTNALGQTTSLERDALGQIIRKDADGHVTTFSYDVTDEPAQATGPDGCRVSILRDRHGRVRSETVDGRELTYVYDELGRRTGRTTPTGGATTWSFDAVGRRTDLVVSGRAVDLRYDAAGRETARHIGATITLEQAFDPLGRLSAQSVTDADGHTVQHRAYSYRADGHLTAVDDRLGGARRFDLDAVGRVTAVHAAGWTETYAYDTAGNQTSASWPAEHPGQEATGPRTYQGTRITRAGSVRYEHDALGRITLRQKTRLSRKPDTWRYEWDAEDRLVSVVTPDGTRWRYTYDPLGRRTAKLRIGADGATVVERTVFTWDGSTLCEQTTSAPQFPHPVTLTWDHMGRRPLAQTERIHAADAPQTEIDSRFFAIVTDLVGTPSELVDEQGRVAWHARSTLWGTTTWTANSATYTPLRFPGQYFDPETGLHYNYFRHYDPQTGRYLTPDPLGLTPAPNPAAYVDNPHTWSDPLGLAPEYDGDGPKKEPQGGDHPDDPRGYSKPSIGRYDYSWSNYDRAVSAAREHAGGDLGADSIKMYDRNPNTHEGTGTLIGEQTPDKMRGWRIDGPDGHVNYWDWSGGKKGAGGLYGHDWYPDDPTTPGSRYIGWAPWQDNAGNFLEGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JI08</accession>
    <name>A0A2M9JI08_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Serine protease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CG723_38985</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CB01635</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the peptidase S8 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000029">
        <property type="protein sequence ID" value="PJN06526.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN06526">
        <property type="protein sequence ID" value="PJN06526"/>
        <property type="gene ID" value="CG723_38985"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0110165">
        <property type="term" value="C:cellular anatomical entity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04077">
        <property type="entry name" value="Peptidases_S8_PCSK9_ProteinaseK_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034193">
        <property type="entry name" value="PCSK9_ProteinaseK-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000209">
        <property type="entry name" value="Peptidase_S8/S53_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023827">
        <property type="entry name" value="Peptidase_S8_Asp-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023828">
        <property type="entry name" value="Peptidase_S8_Ser-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015500">
        <property type="entry name" value="Peptidase_S8_subtilisin-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010259">
        <property type="entry name" value="S8pro/Inhibitor_I9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037045">
        <property type="entry name" value="S8pro/Inhibitor_I9_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05922">
        <property type="entry name" value="Inhibitor_I9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00082">
        <property type="entry name" value="Peptidase_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00723">
        <property type="entry name" value="SUBTILISIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="SSF52743"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00136">
        <property type="entry name" value="SUBTILASE_ASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00138">
        <property type="entry name" value="SUBTILASE_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 5 10" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0720">Serine protease</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014876957" evidence="7">
        <location>
            <begin position="34"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="domain" description="Inhibitor I9" evidence="9">
        <location>
            <begin position="53"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_S8" evidence="8">
        <location>
            <begin position="152"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="381"/>
            <end position="401"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF05922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PJN06526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="401" mass="41089" checksum="695F78F526FFB7A1" modified="2018-04-25" version="1">MTLTRRRRLRRAGALTAVTTAAVLSAVTLPAHAAPRLGRVLGAGEPGSVTGSYIVTLKGGTKAPSDSGKGLAEKYGVKIRHTYSTALNGYAVRAGETQARRLAADPSVAAVVQDSRVSLDHTRKNPPSWGLDRIDQGDLPLDKSYTWPESAGSGVTAYVIDTGIRISHRDFGGRAHYGWDFVDGDATAQDGNGHGTHVAATVAGTGYGVAKKADVVAVRVLDDAGSGTTAQVIAGIDWVTKNARKPAVANLSLGGSANAQLDAAVRGSIASGVTYTVAAGNDGLPASLYSPARVKEAITVGATDRTDRRAGFSNWGTRLDLFAPGVDITAAGYASDKGKATFSGTSMASPHVAGAAALYLADHASATPAEVSRALTGRAATGRITDPLPGSPNKLLQVKLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JI79</accession>
    <name>A0A2M9JI79_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_38405</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000028">
        <property type="protein sequence ID" value="PJN06574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN06574">
        <property type="protein sequence ID" value="PJN06574"/>
        <property type="gene ID" value="CG723_38405"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="63"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="88"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN06574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="129" mass="13906" checksum="FD01DCBFD736EDDC" modified="2018-04-25" version="1">MDSWLVVMETMSLTTTSRRRHGLLAGAVLLTVLSAALLAAHVSFDGDTFQHCRYLGPSTRMYVTAWAGPLCSAAVLVAHGFRRGRAWPVTVCAVLALLLLCVQFVALYWVYAPEPSGGYDCSGIASLTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JIZ5</accession>
    <name>A0A2M9JIZ5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_36720</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000025">
        <property type="protein sequence ID" value="PJN06830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN06830">
        <property type="protein sequence ID" value="PJN06830"/>
        <property type="gene ID" value="CG723_36720"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029046">
        <property type="entry name" value="LolA/LolB/LppX"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89392">
        <property type="entry name" value="SSF89392"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014883503" evidence="2">
        <location>
            <begin position="32"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="224"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="237"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN06830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="254" mass="26364" checksum="662BADC36D48DC52" modified="2018-04-25" version="1">MRRSTLAALCLTVVTAAVSLTACGPGGPGDAAGPGDKPKAPFADLSGPEIANKAMKATRGATSLTIKGNAADGEGGQIALDVALDRKGECAGSMGMKGQGRVDLIKTGPTMYLKSDEAFLRAQSEGESKADTDAVVKMLAGRWMKSKADSPDAKDMAAFCDLDSLLAEFKSNDTLARKGRATTVDGTPAFTVTETDGKDEYTLYVATEGRPYVLKLVTKSAKEPGSLTFSDYDKPVEAAPPADKDVVDLDKMGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JJB1</accession>
    <name>A0A2M9JJB1_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">GPI-anchored domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CG723_36325</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000024">
        <property type="protein sequence ID" value="PJN06960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN06960">
        <property type="protein sequence ID" value="PJN06960"/>
        <property type="gene ID" value="CG723_36325"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0110165">
        <property type="term" value="C:cellular anatomical entity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018466">
        <property type="entry name" value="Kre9/Knh1-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10342">
        <property type="entry name" value="GPI-anchored"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014993646" description="GPI-anchored domain-containing protein" evidence="2">
        <location>
            <begin position="24"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="domain" description="GPI-anchored" evidence="3">
        <location>
            <begin position="33"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="114"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF10342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PJN06960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="135" mass="13476" checksum="065750A91A0D6524" modified="2018-04-25" version="1">MRRTGFLTLATASLLFAPGPVAAAEPDAAVTVTAPAADSVPPAGGSLFVGWDNSTGQEVGMWLVRGEADRVVQFAAKLTDAPSGETATVLPDVPEGAGYTIEIVARDGGEQGYSASFSVGQEPQGAAGPAAPAAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JJE2</accession>
    <name>A0A2M9JJE2_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 5">Argininosuccinate lyase</fullName>
            <shortName evidence="5">ASAL</shortName>
            <ecNumber evidence="3 5">4.3.2.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Arginosuccinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5 8" type="primary">argH</name>
        <name evidence="8" type="ORF">CG723_36490</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CB01635</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 5">
            <text>2-(N(omega)-L-arginino)succinate = fumarate + L-arginine</text>
            <dbReference type="Rhea" id="RHEA:24020"/>
            <dbReference type="ChEBI" id="CHEBI:29806"/>
            <dbReference type="ChEBI" id="CHEBI:32682"/>
            <dbReference type="ChEBI" id="CHEBI:57472"/>
            <dbReference type="EC" id="4.3.2.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 5">Amino-acid biosynthesis; L-arginine biosynthesis; L-arginine from L-ornithine and carbamoyl phosphate: step 3/3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the lyase 1 family. Argininosuccinate lyase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.3.2.1" evidence="3 5"/>
    <dbReference type="EMBL" id="NNBL01000024">
        <property type="protein sequence ID" value="PJN06983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN06983">
        <property type="protein sequence ID" value="PJN06983"/>
        <property type="gene ID" value="CG723_36490"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00068">
        <property type="reaction ID" value="UER00114"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004056">
        <property type="term" value="F:argininosuccinate lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042450">
        <property type="term" value="P:arginine biosynthetic process via ornithine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01359">
        <property type="entry name" value="Argininosuccinate_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.275.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00006">
        <property type="entry name" value="Arg_succ_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029419">
        <property type="entry name" value="Arg_succ_lyase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009049">
        <property type="entry name" value="Argininosuccinate_lyase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024083">
        <property type="entry name" value="Fumarase/histidase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020557">
        <property type="entry name" value="Fumarate_lyase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000362">
        <property type="entry name" value="Fumarate_lyase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022761">
        <property type="entry name" value="Fumarate_lyase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008948">
        <property type="entry name" value="L-Aspartase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43814">
        <property type="entry name" value="PTHR43814"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14698">
        <property type="entry name" value="ASL_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00206">
        <property type="entry name" value="Lyase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00149">
        <property type="entry name" value="FUMRATELYASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48557">
        <property type="entry name" value="SSF48557"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00838">
        <property type="entry name" value="argH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00163">
        <property type="entry name" value="FUMARATE_LYASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="4 5" id="KW-0055">Arginine biosynthesis</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 8" id="KW-0456">Lyase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lyase_1" evidence="6">
        <location>
            <begin position="13"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="domain" description="ASL_C2" evidence="7">
        <location>
            <begin position="370"/>
            <end position="437"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012338"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF14698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PJN06983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="477" mass="51966" checksum="40D3EF663927966C" modified="2018-04-25" version="1">MTDTAATTRLWGGRFRSAPDEALTTLSRSDPSYFAMAPYDLAGSRSHARELHRAGLLDDAELATLLDAIDVLDGEYRRGEVHPNLEDEDVHTFLERVLSERLGAVGGKLRAGRSRNDQAANDLRLYLRDQVRRLAEATVDLTDALLAQTRRHRATPAPGFTHLQPAQPITFGHQLLAHAHALGRDIDRLRDWDRRSARSPLGAAALAGSAIALTPEHSARELGYERTCANSIDAVASRDHVAEFLFVGSMLAVDVSRLAEEICLWASRQFRWIALDDRFATGSSIMPQKKNPDIAELARGKAGRLTGNLTGVLGALKGLPLAYNRDLAEDKRAAFDTVETLLMVLPAMSGLVRTFVVDEKELRAQATAGFTLATEIADWLARRGVPFSEAHEITGAVVRLCEERGVDLEELSDEDYAGVDARLTPEVRSVLSVEAALAARSGQGGTAPVRVDEQIGELVALVAEQRAWAAEYAGPRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JK17</accession>
    <name>A0A2M9JK17_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_35045</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000022">
        <property type="protein sequence ID" value="PJN07208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN07208">
        <property type="protein sequence ID" value="PJN07208"/>
        <property type="gene ID" value="CG723_35045"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014702583" evidence="1">
        <location>
            <begin position="23"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN07208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="285" mass="31053" checksum="85B5E2C39778B141" modified="2018-04-25" version="1">MRIRTAAVLVAALVSLVSVAACDTGTPVPEDLVVTGSSPAAPYHGPLKAKAPDIDGDEDNVQGGGASVLALECAGKPYQGGSGDDGWGTSDGADSPDQALSSLVADEFSRSLPRRGYRVEREAGRRVLYSYDVGSRTRVAVIVAKDLPRRPGWGLETYAQCDPSEFARRDRAHLDIRVWVDRKGRPAPASEIFSTAGPEHCDWQSAEFLHLGDRQYLRDPEHSLPRELLHSSYGPKTRLPQEAMDTGYRDGRRQLWLSADKLDAYVRTGSVVERWPGAIEPIACR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JK43</accession>
    <name>A0A2M9JK43_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SnoaL-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_35155</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000022">
        <property type="protein sequence ID" value="PJN07230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN07230">
        <property type="protein sequence ID" value="PJN07230"/>
        <property type="gene ID" value="CG723_35155"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037401">
        <property type="entry name" value="SnoaL-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13577">
        <property type="entry name" value="SnoaL_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="SSF54427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SnoaL-like" evidence="1">
        <location>
            <begin position="10"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN07230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="166" mass="18305" checksum="11C9D386BC2D9FEB" modified="2018-04-25" version="1">MTQRVELATVMDRLAIEELITDYAVSVDDGDWTAYRGLFSPDGRADYRRAGGIEGSAAEITEWLTRTMELFPMRQHLIVNRRLRFGRLDNDTGDTADVQADYINPMRFAGDGAGTAADAPSGAPDFVCGGRYAFALVRTRSGWRLGGVTVHEKWRRTEGAAAATTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-06-02" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JK45</accession>
    <name>A0A2M9JK45_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 8 10">Uracil-DNA glycosylase</fullName>
            <shortName evidence="8">UDG</shortName>
            <ecNumber evidence="4 8 10">3.2.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">ung</name>
        <name evidence="12" type="ORF">CG723_35190</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">CB01635</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 8 10">Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8 10">
            <text>Hydrolyzes single-stranded DNA or mismatched double-stranded DNA and polynucleotides, releasing free uracil.</text>
            <dbReference type="EC" id="3.2.2.27"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 8 10">Belongs to the uracil-DNA glycosylase (UDG) superfamily. UNG family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.2.27" evidence="4 8 10"/>
    <dbReference type="EMBL" id="NNBL01000022">
        <property type="protein sequence ID" value="PJN07236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN07236">
        <property type="protein sequence ID" value="PJN07236"/>
        <property type="gene ID" value="CG723_35190"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004844">
        <property type="term" value="F:uracil DNA N-glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006284">
        <property type="term" value="P:base-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd10027">
        <property type="entry name" value="UDG-F1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00148">
        <property type="entry name" value="UDG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002043">
        <property type="entry name" value="UDG_fam1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018085">
        <property type="entry name" value="Ura-DNA_Glyclase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005122">
        <property type="entry name" value="Uracil-DNA_glycosylase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036895">
        <property type="entry name" value="Uracil-DNA_glycosylase-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11264">
        <property type="entry name" value="PTHR11264"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03167">
        <property type="entry name" value="UDG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00986">
        <property type="entry name" value="UDG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52141">
        <property type="entry name" value="SSF52141"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00628">
        <property type="entry name" value="ung"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00130">
        <property type="entry name" value="U_DNA_GLYCOSYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 8 10" id="KW-0227">DNA damage</keyword>
    <keyword evidence="7 8 10" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6 8 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UDG" evidence="11">
        <location>
            <begin position="52"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="8 9">
        <location>
            <position position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001400"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PJN07236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="227" mass="25276" checksum="8C4706B50C981DDA" modified="2018-04-25" version="1">MTDTAMLPESWRGVLGEELQKSYFKELTEFVEEERAKGPVYPPREEVFAALDATPYDRVKVLVLGQDPYHGEGQGHGLCFSVRPGVKTPPSLRNIYKEMKEELGHPVPDNGYLMPWAEQGVLLLNAVLTVRAGEANSHKGKGWEKFTDAVIRAVADRPDPAVFVLWGNYAQKKLPLIDEERHVVVKGAHPSPLSAKKFFGSHPFTQIDKAVAAQGHTPIDWRIPDLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-09-29" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JK70</accession>
    <name>A0A2M9JK70_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">MerR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_35340</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000022">
        <property type="protein sequence ID" value="PJN07264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN07264">
        <property type="protein sequence ID" value="PJN07264"/>
        <property type="gene ID" value="CG723_35340"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000551">
        <property type="entry name" value="MerR-type_HTH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00376">
        <property type="entry name" value="MerR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00422">
        <property type="entry name" value="HTH_MERR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="SSF46955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50937">
        <property type="entry name" value="HTH_MERR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH merR-type" evidence="2">
        <location>
            <begin position="37"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="99"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN07264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="247" mass="26665" checksum="60818837B52571B9" modified="2018-04-25" version="1">MLQTPKGGAGHGIALTDSRLMSIGTVLNVLRDEFPEVTISKIRFLESEGLIEPQRTPSGYRKFSPDDVERLAHVLRMQRDHYLPLKVIKEQLDALERGEAITLPSTGRPGGSEDGRASEGGEGPTAARVGRDELLAAAGIASPELDEWESYGLIAPLPEGGYDAEAVTVAELVMELGRFGIEPRHLRAMKAAADREAGLVDQVVAPLRRHRNPQTRAHAQARAKELAGLTVKLHGALVQTALGVRLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-05-25" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JK98</accession>
    <name>A0A2M9JK98_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Elongation factor P</fullName>
            <shortName evidence="7">EF-P</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7 11" type="primary">efp</name>
        <name evidence="11" type="ORF">CG723_34135</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CB01635</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 7">Protein biosynthesis; polypeptide chain elongation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 7 8">Belongs to the elongation factor P family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000021">
        <property type="protein sequence ID" value="PJN07295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN07295">
        <property type="protein sequence ID" value="PJN07295"/>
        <property type="gene ID" value="CG723_34135"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00345"/>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04470">
        <property type="entry name" value="S1_EF-P_repeat_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05794">
        <property type="entry name" value="S1_EF-P_repeat_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00141">
        <property type="entry name" value="EF_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015365">
        <property type="entry name" value="Elong-fact-P_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_L2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020599">
        <property type="entry name" value="Transl_elong_fac_P/YeiP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013185">
        <property type="entry name" value="Transl_elong_KOW-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001059">
        <property type="entry name" value="Transl_elong_P/YeiP_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013852">
        <property type="entry name" value="Transl_elong_P/YeiP_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011768">
        <property type="entry name" value="Transl_elongation_fac_P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30053">
        <property type="entry name" value="PTHR30053"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01132">
        <property type="entry name" value="EFP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08207">
        <property type="entry name" value="EFP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09285">
        <property type="entry name" value="Elong-fact-P_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005901">
        <property type="entry name" value="EF-P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01185">
        <property type="entry name" value="EFP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00841">
        <property type="entry name" value="Elong-fact-P_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="SSF50104"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00038">
        <property type="entry name" value="efp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01275">
        <property type="entry name" value="EFP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 7 11" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="6 7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EFP" evidence="10">
        <location>
            <begin position="68"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="domain" description="Elong-fact-P_C" evidence="9">
        <location>
            <begin position="130"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM01185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PJN07295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="188" mass="20619" checksum="22110B99CD963AF4" modified="2018-04-25" version="1">MASTNDLKNGLVLKLDGGQLWSVVEFQHVKPGKGPAFVRTKLKNVLSGKVVDKTFNAGVKVETATIDKRDMQFSYMDGEYFVFMDMQTYDQLMVDRKSVGDAANFLIEGFNASVAQHEGEVLFVELPAAVELVVQETEPGVQGDRSTGGTKPATLETGHQIQVPLFITTGEKIKVDTRTSDYLGRVNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JKB7</accession>
    <name>A0A2M9JKB7_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Coenzyme A biosynthesis bifunctional protein CoaBC</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">DNA/pantothenate metabolism flavoprotein</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="3">Phosphopantothenoylcysteine synthetase/decarboxylase</fullName>
            <shortName evidence="3">PPCS-PPCDC</shortName>
        </alternativeName>
        <domain>
            <recommendedName>
                <fullName evidence="3">Phosphopantothenoylcysteine decarboxylase</fullName>
                <shortName evidence="3">PPC decarboxylase</shortName>
                <shortName evidence="3">PPC-DC</shortName>
                <ecNumber evidence="3">4.1.1.36</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="3">CoaC</fullName>
            </alternativeName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="3">Phosphopantothenate--cysteine ligase</fullName>
                <ecNumber evidence="3">6.3.2.5</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="3">CoaB</fullName>
            </alternativeName>
            <alternativeName>
                <fullName evidence="3">Phosphopantothenoylcysteine synthetase</fullName>
                <shortName evidence="3">PPC synthetase</shortName>
                <shortName evidence="3">PPC-S</shortName>
            </alternativeName>
        </domain>
    </protein>
    <gene>
        <name evidence="3 7" type="primary">coaBC</name>
        <name evidence="7" type="ORF">CG723_34205</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CB01635</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes two sequential steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine. In the second step the latter compound is decarboxylated to form 4'-phosphopantotheine.</text>
    </comment>
    <comment type="function">
        <text evidence="4">Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3 4">
            <text>(R)-4'-phosphopantothenate + CTP + L-cysteine = CMP + diphosphate + H(+) + N-[(R)-4-phosphopantothenoyl]-L-cysteine</text>
            <dbReference type="Rhea" id="RHEA:19397"/>
            <dbReference type="ChEBI" id="CHEBI:10986"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:35235"/>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
            <dbReference type="ChEBI" id="CHEBI:59458"/>
            <dbReference type="ChEBI" id="CHEBI:60377"/>
            <dbReference type="EC" id="6.3.2.5"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3 4">
            <text>H(+) + N-[(R)-4-phosphopantothenoyl]-L-cysteine = (R)-4'-phosphopantetheine + CO2</text>
            <dbReference type="Rhea" id="RHEA:16793"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:59458"/>
            <dbReference type="ChEBI" id="CHEBI:61723"/>
            <dbReference type="EC" id="4.1.1.36"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
        <text evidence="3">Binds 1 FMN per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 4">Cofactor biosynthesis; coenzyme A biosynthesis; CoA from (R)-pantothenate: step 2/5.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 4">Cofactor biosynthesis; coenzyme A biosynthesis; CoA from (R)-pantothenate: step 3/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 4">In the C-terminal section; belongs to the PPC synthetase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 4">In the N-terminal section; belongs to the HFCD (homo-oligomeric flavin containing Cys decarboxylase) superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.36" evidence="3"/>
    <dbReference type="EC" id="6.3.2.5" evidence="3"/>
    <dbReference type="EMBL" id="NNBL01000021">
        <property type="protein sequence ID" value="PJN07308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN07308">
        <property type="protein sequence ID" value="PJN07308"/>
        <property type="gene ID" value="CG723_34205"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00241">
        <property type="reaction ID" value="UER00353"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004632">
        <property type="term" value="F:phosphopantothenate--cysteine ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004633">
        <property type="term" value="F:phosphopantothenoylcysteine decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015937">
        <property type="term" value="P:coenzyme A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015941">
        <property type="term" value="P:pantothenate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1950">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02225">
        <property type="entry name" value="CoaBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035929">
        <property type="entry name" value="CoaB-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005252">
        <property type="entry name" value="CoaBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007085">
        <property type="entry name" value="DNA/pantothenate-metab_flavo_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036551">
        <property type="entry name" value="Flavin_trans-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003382">
        <property type="entry name" value="Flavoprotein"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04127">
        <property type="entry name" value="DFP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02441">
        <property type="entry name" value="Flavoprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102645">
        <property type="entry name" value="SSF102645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52507">
        <property type="entry name" value="SSF52507"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00521">
        <property type="entry name" value="coaBC_dfp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3 4" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="3 4" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3 4" id="KW-0288">FMN</keyword>
    <keyword evidence="3 4 7" id="KW-0436">Ligase</keyword>
    <keyword evidence="2 3 4" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flavoprotein" evidence="5">
        <location>
            <begin position="48"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="domain" description="DFP" evidence="6">
        <location>
            <begin position="230"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="region of interest" description="Phosphopantothenoylcysteine decarboxylase" evidence="3">
        <location>
            <begin position="1"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="region of interest" description="Phosphopantothenate--cysteine ligase" evidence="3">
        <location>
            <begin position="235"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="323"/>
        </location>
        <ligand>
            <name>CTP</name>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="333"/>
        </location>
        <ligand>
            <name>CTP</name>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="351"/>
            <end position="354"/>
        </location>
        <ligand>
            <name>CTP</name>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="371"/>
        </location>
        <ligand>
            <name>CTP</name>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="385"/>
        </location>
        <ligand>
            <name>CTP</name>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="389"/>
        </location>
        <ligand>
            <name>CTP</name>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU364078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PJN07308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="459" mass="49137" checksum="066E70C5A5D466F1" modified="2018-04-25" version="1">MSFSWPQARQRDCRACGVSWSRTGPRGVVRSRVRESECGEARTVDKPKVVLGVSGGIAAYKACELLRRLTESGHDVRVVPTESALHFVGEATWSALSGNPVSTEVWESVHEVPHVRIGQHADLVIVAPATADMLAKAAHGLADDLLTNTLLTARCPVVFAPAMHTEMWEHPATRENVATLRRRGALVIEPAVGRLTGVDTGKGRFPDPVEIFEFARRVLARGDLATTQDLAGRHVVISAGGTREPLDPVRFLGNRSSGKQGYALARTAVARGARVTLLAANATLPDPAGVDVVHIGTAVELREAVLEAAPEADVVVMAAAVADFRPETYATGKIKKKDGQEPEPIVLVRNPDILAELSADRPRPGQIVVGFAAETDDVLANGRKKLARKGCDLLVVNEVGERKTFGSEENEAVLLGADGSEAPVPHGPKEVLSDTIWDAVARLLPIGDERAVERIYDGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JKP8</accession>
    <name>A0A2M9JKP8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alpha/beta hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_33675</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000020">
        <property type="protein sequence ID" value="PJN07449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN07449">
        <property type="protein sequence ID" value="PJN07449"/>
        <property type="gene ID" value="CG723_33675"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00111">
        <property type="entry name" value="ABHYDROLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="27"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN07449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="264" mass="29023" checksum="DF9C29B257496B35" modified="2018-04-25" version="1">MANTLRKGYVPSPFGQLHYVEVGEGTPVLLLHQTPRSWTEYLDVLPLVGARHRAIAMDTLGFGASAKPELPHSIERFADAAGALIDELGLQRVHLVGHHTGGLIAVELAARLRDRVASLLLSATPFVDDEKRRTAAVRQRIDHVDPAPDGSHLQGLWERRRAFYRAGEEAHLNRYVADALAVLDRVEEGHEAVRRYAMEERLAHITARTLAVCAPGDHYSLPSLEKFAAALGCATRVLSDGHVAAPEQVPHEFAEVVLEWAGRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JKR9</accession>
    <name>A0A2M9JKR9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">2-keto-4-pentenoate hydratase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_33800</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000020">
        <property type="protein sequence ID" value="PJN07470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN07470">
        <property type="protein sequence ID" value="PJN07470"/>
        <property type="gene ID" value="CG723_33800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.850.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011234">
        <property type="entry name" value="Fumarylacetoacetase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036663">
        <property type="entry name" value="Fumarylacetoacetase_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01557">
        <property type="entry name" value="FAA_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56529">
        <property type="entry name" value="SSF56529"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAA_hydrolase" evidence="1">
        <location>
            <begin position="106"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN07470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="278" mass="28570" checksum="DC7487B5DAFB3A31" modified="2018-04-25" version="1">MSSAVPPGEDAPPTVVKAADALAEATRTRVATPPVRPLFDEGDLEAAYAVQRLNVQRGLAAGRRLVGRKIGLTSPAVQSQLGVDQPDFGALFADMEVPQGGEVPAGRLLQPKVEAEVVLVLGRDLPHRQCTVADVLRAVDFALPALEIVDSRIADWDISLVDTVADNASCGLYVLGGTPVPLTGIDLRAVEMTMTRGGETVSRGTGADCLGSPLVAAAWLASTLAERGDPLRAGDVVLTGALGPMVPAAAGDVFDATITGLGSVQVTFATEGTEGADK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JKV5</accession>
    <name>A0A2M9JKV5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GNAT family N-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_34025</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000020">
        <property type="protein sequence ID" value="PJN07505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN07505">
        <property type="protein sequence ID" value="PJN07505"/>
        <property type="gene ID" value="CG723_34025"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="123"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN07505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="263" mass="28295" checksum="5970500A5DF1E8A0" modified="2018-04-25" version="1">MNHQAVLGLFDRQMRRGARPDGPGARVERVDGVVRQTGAEGSSWNGVVWSDLDEGSADAAIAAQVRHFTGLGREFEWKVYGHDLPHDLPQRLTAAGFLPEPVETLLVAEVADLPTDVPLPEGIRLLPVTDEAGVDLMSEVHDKAFGRSLGLTRHQLLAQLAEDPDAVPAVLALAGDVPVSAARMETHPGTDFASLWGGGTVAEWRGRGIYRSLVAFRTRIAAERGYRYLQVDASSMSRPILERLGFAALSTTTPYVHDASGGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JL61</accession>
    <name>A0A2M9JL61_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Serine/threonine protein kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_33135</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000019">
        <property type="protein sequence ID" value="PJN07611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN07611">
        <property type="protein sequence ID" value="PJN07611"/>
        <property type="gene ID" value="CG723_33135"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="SSF49785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0675">Receptor</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="337"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="394"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="47"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN07611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="572" mass="61249" checksum="E6912BA406F64188" modified="2018-04-25" version="1">MAERSTAAVDVADNSGDEPLTAKAEQTTADGVAQTRERDTAANEDAEDTDGSTSPGSSTPPELHSGHKLARRYRLEECVTRLDGFSSWRAVDEKLRRAVGVHLLPADHPRARSVLAAARSSALLGDPRFVQVLDAVEENDLVYVVHEWLPDATELTALLASGPLEVHEAYQLVNQVSHAMAAAHREGLAHLRLTPSAVLRTSTGQWRIRGLAVNAALRGITSETPQRTDTEAIGALLYAALTQRWPYEDDAYGLSGLPKDIGLIAPDQVRAGVHRGLSELAMRALVNEGATASRQDPPCTTTEDLVKAVGEMPRIRPPEPVFTAPAEYQRTTYQQGTYGRQAPRPGVAQPMPAAPPPPLQSRTGKALKWAVSALLIVALGLGSWQLAEALMDRGTSGDSNTSHNTDGNDKGNDHKPTKPMAIEDAREYVVKGEAQAPGEVAKTYDGDSKTFWRTKTYNDGPKLAPYKPGVGIVYDLGSAKDVSAASIALQYGGDHTTVSLYATDSLSPTTSIDSMKSIGTDTTTGTTAKIEADKPVKTRYVLLWMTALPQSGSDGYYGAGYKQALTDVKFTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-06-02" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JLJ5</accession>
    <name>A0A2M9JLJ5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_32255</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000018">
        <property type="protein sequence ID" value="PJN07744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN07744">
        <property type="protein sequence ID" value="PJN07744"/>
        <property type="gene ID" value="CG723_32255"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN07744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="415" mass="45704" checksum="B25806540D074695" modified="2018-04-25" version="1">MTRPRRGPSKITSTPPRSSGERVELAGIIAADWLRHALSAGPSDRARAEAAVTGLYRRLGEPAPDFVWVPSPAAARPVLLDAPHRFRPPRLRGTQAPRRPTDWPLVSRLANLVVDLRDRLDERTGSAIAWQSWYGTTAPRTMTVPEALAAGFPVRDVVDAVGRHPLRTTVDDAVRAPIRAELMRTEGEAAALTWYGQHDAAWIAHYDIRARVGLATYAHDDVAHLGLWAELARSTGWWWPGQGVCVMSERPAEIHTESQPGALHGESRLHRDDAPAVRYADGAAVHVLHGAHVPEWVLTDPTPERIHAEPNIEVRRSAIERIGWARYIGRAGLRLVSSAPDPGNPNSELQLYDVPLALWGRPTRLLLAVNGSVEPDGHRRRYGLSVPAHFDDPVAAAGWSYGLSGEHYAQLLRRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JLM3</accession>
    <name>A0A2M9JLM3_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Phenylalanine--tRNA ligase alpha subunit</fullName>
            <ecNumber evidence="13">6.1.1.20</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Phenylalanyl-tRNA synthetase alpha subunit</fullName>
            <shortName evidence="13">PheRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="primary">pheS</name>
        <name evidence="15" type="ORF">CG723_32325</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">CB01635</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 13">
            <text>ATP + L-phenylalanine + tRNA(Phe) = AMP + diphosphate + H(+) + L-phenylalanyl-tRNA(Phe)</text>
            <dbReference type="Rhea" id="RHEA:19413"/>
            <dbReference type="Rhea" id="RHEA-COMP:9668"/>
            <dbReference type="Rhea" id="RHEA-COMP:9699"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58095"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78531"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.20"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="13">Binds 2 magnesium ions per tetramer.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4 13">Tetramer of two alpha and two beta subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 13">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.20" evidence="13"/>
    <dbReference type="EMBL" id="NNBL01000018">
        <property type="protein sequence ID" value="PJN07758.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN07758">
        <property type="protein sequence ID" value="PJN07758"/>
        <property type="gene ID" value="CG723_32325"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004826">
        <property type="term" value="F:phenylalanine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006432">
        <property type="term" value="P:phenylalanyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00281">
        <property type="entry name" value="Phe_tRNA_synth_alpha1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004529">
        <property type="entry name" value="Phe-tRNA-synth_IIc_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004530">
        <property type="entry name" value="Phe-tRNA-synth_IIc_mito"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004188">
        <property type="entry name" value="Phe-tRNA_ligase_II_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022911">
        <property type="entry name" value="Phe_tRNA_ligase_alpha1_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002319">
        <property type="entry name" value="Phenylalanyl-tRNA_Synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010978">
        <property type="entry name" value="tRNA-bd_arm"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11538:SF41">
        <property type="entry name" value="PTHR11538:SF41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02912">
        <property type="entry name" value="Phe_tRNA-synt_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01409">
        <property type="entry name" value="tRNA-synt_2d"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46589">
        <property type="entry name" value="SSF46589"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00468">
        <property type="entry name" value="pheS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12 13" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="9 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 13" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 13 15" id="KW-0436">Ligase</keyword>
    <keyword evidence="10 13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11 13" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AA_TRNA_LIGASE_II" evidence="14">
        <location>
            <begin position="127"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="278"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="PJN07758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="374" mass="41120" checksum="1CDBCAD59AB5B7DB" modified="2018-04-25" version="1">MSAPNKSYDPVEVEALKPEEIERMRDEALAAFAAADSLGALQEAKVAHTGGTSPLSLANREIGALPPQAKAEAGKRVGMARGAVSKALAARQTELEAERDARVLVEEAVDVTLPYDRTPAGARHPLTTLSERIEDVFVAMGYEVAEGPEVEAEWFNFDALNIGPDHPARGMQDTFFVEGPKGRETESNVVLRTHTSPVQIRSMLDREPPVYVICPGRVYRSDELDATHTPVFMQVELLAVDEGLTMSDLKGTLDHMVQALFGEGMKTRLRPNFFPFTEPSAEMDMVCYVCRGESVGNPDRPCRTCSSEGWIELGGCGMVNPKVLTAAGIDPEKYSGFAFGFGIERMLMFRHNVEDMRDMVEGDIRFTRPFGMEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JLP9</accession>
    <name>A0A2M9JLP9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CG723_32540</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000018">
        <property type="protein sequence ID" value="PJN07794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN07794">
        <property type="protein sequence ID" value="PJN07794"/>
        <property type="gene ID" value="CG723_32540"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PJN07794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="65" mass="7002" checksum="60D65D5104139059" modified="2018-04-25" version="1">MFWAMLAIAVGFVGLAVLGVLAVKVFVEAQRLGRQVADTTQQINRAAEDLERAATSAARTSRELL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JLU8</accession>
    <name>A0A2M9JLU8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_31040</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000017">
        <property type="protein sequence ID" value="PJN07843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN07843">
        <property type="protein sequence ID" value="PJN07843"/>
        <property type="gene ID" value="CG723_31040"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001845">
        <property type="entry name" value="HTH_ArsR_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00778">
        <property type="entry name" value="HTHARSR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00418">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50987">
        <property type="entry name" value="HTH_ARSR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH arsR-type" evidence="1">
        <location>
            <begin position="9"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN07843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="190" mass="21310" checksum="6CF1C481519A95D4" modified="2018-04-25" version="1">MTKERRAEVAGQRTVDSPEVLKALSHPLRLRILRHLGAAGPATSTTLAAALGENTGTLSYHLRMLERSGLIEDIPERSTGRERWWRGVRGLDIRRPPLGELTEAERAMSAELDRMRMEEDVGLARQFTAGQAESEGWMRGSRSLIHLTKSELDAFHDDYLALLARYTRGPEDAPDDARPVLLRWFGLPAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-05-25" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JM74</accession>
    <name>A0A2M9JM74_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 14">Undecaprenyl-diphosphatase</fullName>
            <ecNumber evidence="4 14">3.6.1.27</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13 14">Bacitracin resistance protein</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12 14">Undecaprenyl pyrophosphate phosphatase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="primary">uppP</name>
        <name evidence="15" type="ORF">CG723_30205</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">CB01635</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 14">
            <text>di-trans,octa-cis-undecaprenyl diphosphate + H2O = di-trans,octa-cis-undecaprenyl phosphate + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:28094"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58405"/>
            <dbReference type="ChEBI" id="CHEBI:60392"/>
            <dbReference type="EC" id="3.6.1.27"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="14">Cell membrane</location>
            <topology evidence="14">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="miscellaneous">
        <text evidence="14">Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the UppP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.27" evidence="4 14"/>
    <dbReference type="EMBL" id="NNBL01000016">
        <property type="protein sequence ID" value="PJN07976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN07976">
        <property type="protein sequence ID" value="PJN07976"/>
        <property type="gene ID" value="CG723_30205"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050380">
        <property type="term" value="F:undecaprenyl-diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016311">
        <property type="term" value="P:dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046677">
        <property type="term" value="P:response to antibiotic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01006">
        <property type="entry name" value="Undec_diphosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003824">
        <property type="entry name" value="UppP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30622">
        <property type="entry name" value="PTHR30622"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02673">
        <property type="entry name" value="BacA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00753">
        <property type="entry name" value="undec_PP_bacA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 14" id="KW-0046">Antibiotic resistance</keyword>
    <keyword evidence="6 14" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="14" id="KW-0133">Cell shape</keyword>
    <keyword evidence="14" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="8 14 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="46"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="93"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="121"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="192"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="223"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="257"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010621"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00021581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00032707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00032932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="PJN07976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="278" mass="29572" checksum="601BB7187014169A" modified="2018-04-25" version="1">MSAISIGQAVILGVVEGVTEFLPVSSTGHLKITEGLMNIPVDDKSVVAFTAVIQVGAIAAVLLYFFKDIVRILGAWGRGLRHRDQRYHHDYKFAWWVIYATIPVVIVGLAAKPLIEGPLASLWVVAGSLIVGSGLMWAADQMGRHKRGEDDTSLKDAMLVGSSQILALLFPGFSRSGATMSTGLILDLDRVAATRLSFFLGIPALTGAGLYELKDAVGAGADSAPLVVGTVVSFVVAYASIAWLLKYVARHSFNAFVIYRVIIGVLLFALLGTGTLNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JMF5</accession>
    <name>A0A2M9JMF5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_30600</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0065 (bug) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000016">
        <property type="protein sequence ID" value="PJN08038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08038">
        <property type="protein sequence ID" value="PJN08038"/>
        <property type="gene ID" value="CG723_30600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005064">
        <property type="entry name" value="BUG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042100">
        <property type="entry name" value="Bug_dom1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42928">
        <property type="entry name" value="PTHR42928"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03401">
        <property type="entry name" value="TctC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017082">
        <property type="entry name" value="YflP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN08038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="348" mass="35945" checksum="2168B3ACF98579EF" modified="2018-04-25" version="1">MSPFVPPGPVPRPPGLRRPVLFAFFATALTAALGGCAFGPVDSGATVEDYPARGLAILAPGSVGGGFDSRARGIGSALNKCGITGQDITVSNAPGAAGTIGLARMAGRADDPYQLMTMDTVTLLGGEIQNHSPVSLTQLTPVAGLTVSTTAIVVPAHSSHRDFASLMRAMAKNPRGTKWVGGSLGGPDHITVASLAESAHVPPDKVTYVPTGGGGEVLNMLLSGVATAGLSTLSEIRPQVEAGKLRILAVSGGDSPKDLGTPPTLEHLGYGKDAVDAIGGVMAPPGLNRTEQRAVVALMDKMRHTDCWKRTLRENDWDEVWLPGKKFGDLIRRQRGQVGGVLKEVGLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JMI9</accession>
    <name>A0A2M9JMI9_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SHOCT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_30830</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000016">
        <property type="protein sequence ID" value="PJN08078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08078">
        <property type="protein sequence ID" value="PJN08078"/>
        <property type="gene ID" value="CG723_30830"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018649">
        <property type="entry name" value="SHOCT"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09851">
        <property type="entry name" value="SHOCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SHOCT" evidence="2">
        <location>
            <begin position="74"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="23"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN08078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="102" mass="10858" checksum="3A998B805567BAB2" modified="2018-04-25" version="1">MPQRFGRPGLLGTIARTAVISGTATAVSSRVDRRIGERDARRQTESQAQQQASAQQPPPPQQPAAPPAADRVSQLTALAELKAQGLLTDEEFAAEKARVLNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JML9</accession>
    <name>A0A2M9JML9_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Serine hydroxymethyltransferase</fullName>
            <shortName evidence="7">SHMT</shortName>
            <shortName evidence="7">Serine methylase</shortName>
            <ecNumber evidence="7">2.1.2.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">glyA</name>
        <name evidence="10" type="ORF">CG723_30735</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CB01635</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + glycine + H2O = (6S)-5,6,7,8-tetrahydrofolate + L-serine</text>
            <dbReference type="Rhea" id="RHEA:15481"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15636"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="EC" id="2.1.2.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 7 8">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2 7">Amino-acid biosynthesis; glycine biosynthesis; glycine from L-serine: step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="7">One-carbon metabolism; tetrahydrofolate interconversion.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the SHMT family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.2.1" evidence="7"/>
    <dbReference type="EMBL" id="NNBL01000016">
        <property type="protein sequence ID" value="PJN08111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08111">
        <property type="protein sequence ID" value="PJN08111"/>
        <property type="gene ID" value="CG723_30735"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00193"/>
    <dbReference type="UniPathway" id="UPA00288">
        <property type="reaction ID" value="UER01023"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004372">
        <property type="term" value="F:glycine hydroxymethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019264">
        <property type="term" value="P:glycine biosynthetic process from serine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035999">
        <property type="term" value="P:tetrahydrofolate interconversion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00378">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00051">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001085">
        <property type="entry name" value="Ser_HO-MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019798">
        <property type="entry name" value="Ser_HO-MeTrfase_PLP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039429">
        <property type="entry name" value="SHMT-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11680">
        <property type="entry name" value="PTHR11680"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00464">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000412">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00096">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4 7" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="6 7 8" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SHMT" evidence="9">
        <location>
            <begin position="15"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="7">
        <location>
            <begin position="132"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="42"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="62"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="64"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="71"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="72"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="128"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="183"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="211"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="236"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="243"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="373"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="7 8">
        <location>
            <position position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000412-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PJN08111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="441" mass="47248" checksum="C60C5A2481458A7F" modified="2018-04-25" version="1">MTTTTTPASLQALPLSELDPDVAAAVDAELHRQQSTLEMIASENFAPAAVMEAQGSVLTNKYAEGYPGRRYYGGCEHVDVIEQLAIDRVKDLFGAEAANVQPHSGAQANAAAMFALLSPGDTILGLDLAHGGHLTHGMRINFSGKLYNVVPYHVGESDLRIDMDEVERLAREHRPKLIVAGWSAYPRRLDFAAFRRIADEVGAYLMVDMAHFAGLVAAGLHPSPVPYADVVTTTTHKTLGGPRGGVILSRAGLAKRINSAVFPGQQGGPLEHVIAAKAVAFKVAASEEFKERQQRTLDGARILAGRLLSDDVAEAGITVLTGGTEVHLVLVDLRNSALDGQQAEDRLHRVGITVNRNAVPFDPRPPMVSSGLRIGTPALATRGFGAEEFREVADIIAGALKPEHLGEEQAGLLRDRVEKLAHAFPLYPHLPRLPRLNGDAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JMM6</accession>
    <name>A0A2M9JMM6_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Transcriptional regulator WhiB</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">whiB</name>
        <name evidence="14" type="ORF">CG723_29380</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">CB01635</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Acts as a transcriptional regulator. Probably redox-responsive. The apo- but not holo-form probably binds DNA.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="11">Binds 1 [4Fe-4S] cluster per subunit. Following nitrosylation of the [4Fe-4S] cluster binds 1 [4Fe-8(NO)] cluster per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="11">The Fe-S cluster can be nitrosylated by nitric oxide (NO).</text>
    </comment>
    <comment type="PTM">
        <text evidence="11">Upon Fe-S cluster removal intramolecular disulfide bonds are formed.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the WhiB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000015">
        <property type="protein sequence ID" value="PJN08121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08121">
        <property type="protein sequence ID" value="PJN08121"/>
        <property type="gene ID" value="CG723_29380"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035731">
        <property type="term" value="F:dinitrosyl-iron complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01479">
        <property type="entry name" value="WhiB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034768">
        <property type="entry name" value="4FE4S_WBL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003482">
        <property type="entry name" value="Whib"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38839">
        <property type="entry name" value="PTHR38839"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02467">
        <property type="entry name" value="Whib"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51674">
        <property type="entry name" value="4FE4S_WBL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 11" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8 11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 11" id="KW-0408">Iron</keyword>
    <keyword evidence="6 11" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="4 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 11" id="KW-0804">Transcription</keyword>
    <keyword evidence="7 11" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="4Fe-4S Wbl-type" evidence="13">
        <location>
            <begin position="35"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="36"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="66"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="69"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="75"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51674"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="PJN08121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="125" mass="13981" checksum="D7EE031DA45C4BB7" modified="2018-04-25" version="1">MLHPPHQSLQVAAVPPQRGPVRDRDQDAPWHTEAVCRRDEAGLFFAPSKEPTAARLSREEAAKRVCARCPVMVECREHALLQPEPYGVWGGLTAAERRVVLARRRRREVELQKAASSVDQIRAAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JMW2</accession>
    <name>A0A2M9JMW2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NYN domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_29875</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000015">
        <property type="protein sequence ID" value="PJN08213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08213">
        <property type="protein sequence ID" value="PJN08213"/>
        <property type="gene ID" value="CG723_29875"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004540">
        <property type="term" value="F:ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021139">
        <property type="entry name" value="NYN_MARF1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01936">
        <property type="entry name" value="NYN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NYN" evidence="1">
        <location>
            <begin position="34"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN08213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="299" mass="33375" checksum="E42E1CF8E7D6F217" modified="2018-04-25" version="1">MNDDLTAIRVELDRTNELLKRMLAEVAKTPSTHAIFVDAGYLYAAAGRLVTGTEDRRAFDLDAEGIVDALIDKARTIFADSRLLRVYWYDGARRRIHTNEQQSIAELPDVKVRLGNLNAHNQQKGVDSLIRTDLESLARHRAISDAALIGGDEDLVSAVEAAQGYGARVHLWGIEAPEGANQADPLRWEVDSQRTFDLAFFKPYVSRRTATATYENAGTPRPSREDVRFVGAQIAAKWLAARGRESLVELLPGHPYLPGPVDQELLVEAEALLQYSLRGQSDLRRALRDGFWSHLQAQY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JMW5</accession>
    <name>A0A2M9JMW5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DNA-3-methyladenine glycosylase I</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CG723_29775</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000015">
        <property type="protein sequence ID" value="PJN08195.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08195">
        <property type="protein sequence ID" value="PJN08195"/>
        <property type="gene ID" value="CG723_29775"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008725">
        <property type="term" value="F:DNA-3-methyladenine glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006284">
        <property type="term" value="P:base-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005019">
        <property type="entry name" value="Adenine_glyco"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011257">
        <property type="entry name" value="DNA_glycosylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004597">
        <property type="entry name" value="Tag"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03352">
        <property type="entry name" value="Adenine_glyco"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48150">
        <property type="entry name" value="SSF48150"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00624">
        <property type="entry name" value="tag"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PJN08195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="197" mass="21577" checksum="E297E4CA6B382CB1" modified="2018-04-25" version="1">MSDESAGGAVPGPDGALRCPWGLSTEDYVKYHDEEWGRPVHGDDALFERVSLEAFQSGLSWITILRRREGFRAAFAGFKISDVAAFTDTDRERLLADEGIIRNRAKIDATLANARVLADWPEGELDTLIWSHAPDPAARPAPRVIGDVPAITDESTALSKALKKRGLRFVGPTTAYALMQACGLVDDHLVDCMARKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JN91</accession>
    <name>A0A2M9JN91_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Peptidase_M48 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CG723_28500</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CB01635</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="6">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the peptidase M48 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000014">
        <property type="protein sequence ID" value="PJN08332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08332">
        <property type="protein sequence ID" value="PJN08332"/>
        <property type="gene ID" value="CG723_28500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001915">
        <property type="entry name" value="Peptidase_M48"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01435">
        <property type="entry name" value="Peptidase_M48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 6" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="1 6" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4 6" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="81"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="276"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M48" evidence="8">
        <location>
            <begin position="113"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PJN08332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="312" mass="32176" checksum="E7A4C64262A3BDEC" modified="2018-04-25" version="1">MIFAVWIPLLMPLLAVPAARRAAEWLPPRAAAWTLAGFSVVLAGSSTASLGLLASAGALRLPPVAALGRLSPPLLGDGSPVLVPASVLAALALAAGAFALVRTGLRQRREMRAARAGSAGTDELSVRPDELPYAYALPGRPGRIVVTTGMLRSLDAREREVLFAHERAHLAGRHHLFLAAAELAVTLHPMLRGLREPLAYALERWADESAATATGDRALTARAIGRAALAAARFPGAGSRPRTALAVTAGPVPRRVTALLTTSATAARPRKALRRALAGALLVCAALSAGAVADAAHDLHAGVEVAQGETGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JNF8</accession>
    <name>A0A2M9JNF8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_28905</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000014">
        <property type="protein sequence ID" value="PJN08401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08401">
        <property type="protein sequence ID" value="PJN08401"/>
        <property type="gene ID" value="CG723_28905"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="56"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN08401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="75" mass="8546" checksum="3CA77E6613D07412" modified="2018-04-25" version="1">MALRTLSPHPLVELTLPDVMAVVPPPMSATPPARWALFSLMLVREMCRLPSMWRTRRGALPQQRKGTPKDGQRWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JNI7</accession>
    <name>A0A2M9JNI7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">AI-2E family transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CG723_29095</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CB01635</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the autoinducer-2 exporter (AI-2E) (TC 2.A.86) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000014">
        <property type="protein sequence ID" value="PJN08432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08432">
        <property type="protein sequence ID" value="PJN08432"/>
        <property type="gene ID" value="CG723_29095"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002549">
        <property type="entry name" value="AI-2E-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21716">
        <property type="entry name" value="PTHR21716"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01594">
        <property type="entry name" value="AI-2E_transport"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="48"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="73"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="150"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="210"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="239"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="272"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="309"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="348"/>
            <end position="368"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PJN08432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="368" mass="37407" checksum="A55582FD6FD094D5" modified="2018-04-25" version="1">MHTGTGKPLLPEPARRTAAWCVVALLVTGVAAVGIWLCIVFKTAVTPLLLALLGTALLGPVHGWLIRRRVSRALAAILTCVALIAVVGGAGYIVVKTLIDTGDQIVDSVRAAGDWIKDHFGITAADDLGSAAGSLKDLVSKWGASAASGVLAGLSVLGSLLATSVLALLLTFFFLKDSDRAAGLAHSIAPGRAGETLEAMGRRAFQAVEGFMRGTTLIALIDSICITVGLLVLKVPGAVGLGSLVFVGAYIPYLGAAISGAVAVLVALADRGWVTALWVLGVILAVQQLEGHILQPMIQSRTVQMHPAMVMLAITAGASVAGILGMLLAVPVTAAAFGVVGELRTRYSAGEGPAAPSGGSRETSAEGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JNK6</accession>
    <name>A0A2M9JNK6_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CG723_29205</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CB01635</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="NNBL01000014">
        <property type="protein sequence ID" value="PJN08453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08453">
        <property type="protein sequence ID" value="PJN08453"/>
        <property type="gene ID" value="CG723_29205"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005543">
        <property type="entry name" value="PASTA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03793">
        <property type="entry name" value="PASTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00740">
        <property type="entry name" value="PASTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51178">
        <property type="entry name" value="PASTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0418">Kinase</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="11" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="411"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="9">
        <location>
            <begin position="20"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="domain" description="PASTA" evidence="10">
        <location>
            <begin position="476"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="305"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="433"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="530"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="332"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="370"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="534"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="49"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PJN08453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="550" mass="58276" checksum="9973D18E8230137D" modified="2018-04-25" version="1">MSQDGAQGRYAGRAVAGGRYQLRDLLGEGGMASVHLAYDSVLDRQVAIKTLHTELGREQAFRERFRREAQSVAKLTHTNIVSVFDTGEDDLDGMTTPYIVMEYVEGQPLGSVLDADVAHYGAMPTDKALKITADVLAALEISHEMGLVHRDIKPGNVMMTKRNVVKVMDFGIARAMQSGVTSMTQTGMVVGTPQYLSPEQALGRGVDARSDLYSVGIMLFQLVTGRLPFEADSPLAIAYAHVQEEPVAPSSINRSVPPAVDALVARALKKNPNERFPSAEAMRDECLRVAQSLHAAAPSIVPGAQTSSGAGVGSAVFPPVDQSTAAPTGPVQTPYQPGPYGTPAPAPATPGYGYPQQGYQTPPPTSPYAPQQQQYQQQQHQQTPPPYTISPQTTPSSAGSGGGGGKRNTGVIVGSIVVALIAVGGLITALTLNGNDEKGGGDAKKSPSAVAGHKGPDLTKTMEEDECTEPDTGYNDPDKVMLPDFTYKNIKSVKACMQAAGWKFDVRDVDENTFGEGTVIVQYPKARTEIDPKNPESIQLQVSTGDPASG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JNS1</accession>
    <name>A0A2M9JNS1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">D-alanine--poly(Phosphoribitol) ligase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_27455</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000013">
        <property type="protein sequence ID" value="PJN08519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08519">
        <property type="protein sequence ID" value="PJN08519"/>
        <property type="gene ID" value="CG723_27455"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05945">
        <property type="entry name" value="DltA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010071">
        <property type="entry name" value="AA_adenyl_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044507">
        <property type="entry name" value="DltA-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01733">
        <property type="entry name" value="AA-adenyl-dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-binding" evidence="1">
        <location>
            <begin position="16"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding_C" evidence="2">
        <location>
            <begin position="421"/>
            <end position="494"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN08519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="516" mass="54905" checksum="D3D453BB530C521E" modified="2018-04-25" version="1">MSGAKLLHHWFLDGLARNPRGTALRINDRSWTYAEADRTARSWAAALHSGGRAPRRVGVLAAKSEESLLGFLAALYAGCTAVPLNPEYPVGRNRDIAAAAGLDALIVDPSGAAQLDEVAAAAPPLVTLAPRLGEWSGPRPGTPVLMPDPAGDRPPAQGPDSLAYILFTSGSTGRPKGVPIRHGNVSAFLAASLPRYDFGPDDVFGQVYELTFDLSMFEVWCAWSSGACLTVLNRLQALNPGRYIRAHGITVWTSTPSLVAALRTRGLLAGNSLPSVRHTVFCGEPLPEESAAYWSTAAPGTSIDNLYGPTELTIACTAYHWVPSPGAGTVPIGQPNSGLRYVLLDDGQVGADTGELCVTGPQMFDGYLDPANDTDRFLTHDGQRWYRTGDRVRRTPDGTLVHLGRDDGQVKIHGYRVELSEVEEAVRACAPGTEAVVLAVPGAAGPVLAAFVIGDDAAGRLTVTAQDLAHRLPPYMLPAHLWALADPPLNPNGKTDRLRLREEAARRLGRNLAPAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JP63</accession>
    <name>A0A2M9JP63_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">TetR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_26615</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000012">
        <property type="protein sequence ID" value="PJN08673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08673">
        <property type="protein sequence ID" value="PJN08673"/>
        <property type="gene ID" value="CG723_26615"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011075">
        <property type="entry name" value="TetR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19352">
        <property type="entry name" value="TetR_C_38"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="18"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="41"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN08673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="215" mass="23393" checksum="013544F56B578ACA" modified="2018-04-25" version="1">MTGQVRTVDGRVAGRRGQATRQKLLECLGEMLSSSPYRDVKVIDVARKAGTSPATFYQYFPDVEGAVLEIAEQMATEGAGLTQLLEGRSWVGKAGWQTSQELVDGFLEFWRKNDAILRVVDLGAAEGDKRFYKIRMKILNSVNNSLTDTVKELQAKGKVDKDVSPAAMAGSLVAMLAAVASHQKGFQTWGVKQAELKPNLALLVHLGVTGKKPTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JPA2</accession>
    <name>A0A2M9JPA2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Peptidase M23</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_26865</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000012">
        <property type="protein sequence ID" value="PJN08713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08713">
        <property type="protein sequence ID" value="PJN08713"/>
        <property type="gene ID" value="CG723_26865"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011094">
        <property type="entry name" value="Uncharacterised_LppY/LpqO"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07485">
        <property type="entry name" value="DUF1529"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014663953" evidence="1">
        <location>
            <begin position="38"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN08713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="332" mass="35763" checksum="240F8278941E1E32" modified="2018-04-25" version="1">MNDERQQDTRPRLAASRRGVLAALALAPACATVPARAQSLPFGPEGRVLVEPVMTEPADWADVGKALGRTGDMRRFMYHTAFPRRDLTVFSRGILIKPALALGTHVSFVRYADHGTLMMGDTVVTERELQGFCDVLQQRGIMLTAIHKHLLAHDPDVWWVHLHAHGRDPVAVARGVRAALNRTSTPPAEPVTLSPPVDLDTASIDAAMGVKGAVSGEIYTCTYIRRETIADGNLALPPGLGATTSVNFQPLGGGKAAVSGDLVMIAKEVQPVLVALRRGGVELVEVHHHHLNDNPHLFFVHYWAVGDAVRLTEAIRRAVDVTNVVPMAGVAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JPI2</accession>
    <name>A0A2M9JPI2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">LLM class F420-dependent oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_26745</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000012">
        <property type="protein sequence ID" value="PJN08697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08697">
        <property type="protein sequence ID" value="PJN08697"/>
        <property type="gene ID" value="CG723_26745"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019921">
        <property type="entry name" value="Lucif-like_OxRdtase_Rv2161c"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011251">
        <property type="entry name" value="Luciferase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036661">
        <property type="entry name" value="Luciferase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00296">
        <property type="entry name" value="Bac_luciferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51679">
        <property type="entry name" value="SSF51679"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03619">
        <property type="entry name" value="F420_Rv2161c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bac_luciferase" evidence="1">
        <location>
            <begin position="17"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN08697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="276" mass="29969" checksum="F87FD292C780A214" modified="2018-04-25" version="1">MRISTTIFLTDETITPVRLARELEQRGFAGLYLPEHTHIPVERATQWPAGGELPAEYGRTLDPFVALGQAAAVTERLGLGTGITLIAQHDPIDLAKQIATLDHLSGGRFTLGLGFGWNVEEAADHGVEWRTRRELGRERVGLMRALWAQEPTAYDGEFGVSVRASHAYPKPAGGAPRTLIGGAAGPKLFAHITEYADGWLPIGGRGLTESMPVLRAGWEEAGRDPADLHVVPYAVLPSPGKLAHYAELGIDEVVLQLPPADETSVLKILDEYEQYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-06-02" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JPP4</accession>
    <name>A0A2M9JPP4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_25410</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000011">
        <property type="protein sequence ID" value="PJN08841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08841">
        <property type="protein sequence ID" value="PJN08841"/>
        <property type="gene ID" value="CG723_25410"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="86"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="242"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="99"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="130"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="184"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="209"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN08841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="417" mass="43002" checksum="57B4119475C5B9BC" modified="2018-04-25" version="1">MPADEVRHENSAAEFRERTGPRHAAPRKPLFNRLHMPAGKAIAIAAMPTAVLMGMGLTPTLAQAKDNPTKFSADDYKACADAIKASEDGKDATDGKGDESASPTPTPSPSASASKDASDGKEDSGDKAEPTPSPSASKSTDTPSGDSTAGSKTATPTPTPSETKNPLDPLGVGDALKDLLTPDQKESATPTPSASKSTDVGGTVKDTVDKVTEPVKDTADKAGGAVKDTVDKAGKAVDDTADKATKVVPTPSSGETGVPDNCPVATDAEGDNEQTPAQVPNDSWHLEASSLTLKGADYQGVVNVRTPNGTVKKVLKYVISNGTDIGDLHQTVDGPDGKTYHVQAGKGTTSTIRGGTTTMYTESISGNLLGLIPITFDAEHPPPLNIPLIYFTNVKVKQAGQFGGDLHVPGLHQYLTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JPS1</accession>
    <name>A0A2M9JPS1_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Endonuclease NucS</fullName>
            <ecNumber evidence="2">3.1.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">nucS</name>
        <name evidence="3" type="ORF">CG723_25570</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Cleaves both 3' and 5' ssDNA extremities of branched DNA structures.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NucS endonuclease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="2"/>
    <dbReference type="EMBL" id="NNBL01000011">
        <property type="protein sequence ID" value="PJN08868.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08868">
        <property type="protein sequence ID" value="PJN08868"/>
        <property type="gene ID" value="CG723_25570"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000014">
        <property type="term" value="F:single-stranded DNA endodeoxyribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1350.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00722">
        <property type="entry name" value="NucS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002793">
        <property type="entry name" value="Endonuclease_NucS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011856">
        <property type="entry name" value="tRNA_endonuc-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38814">
        <property type="entry name" value="PTHR38814"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01939">
        <property type="entry name" value="NucS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2 3" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN08868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="226" mass="24844" checksum="8D0113AF674BD744" modified="2018-04-25" version="1">MPTMRLVIARCSVDYAGRLTAHLPSAPRLILVKADGSVSIHADDRAYKPLNWMSPPCTLKEGTGDDSGIWTVINKAGEKLIITMEEVLHDSSHELGVDPGLIKDGVEAHLQELLADRIDTLGEGYTLIRREYPTAIGPVDILCRDGDGATVAIEIKRRGEIDGVEQLTRYLELLNRDPHLAPVRGVFAAQEIKPQARVLATDRGIGCTVLDYDALRGIEDDKLRLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JPW7</accession>
    <name>A0A2M9JPW7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_25675</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000011">
        <property type="protein sequence ID" value="PJN08885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08885">
        <property type="protein sequence ID" value="PJN08885"/>
        <property type="gene ID" value="CG723_25675"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="36"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="69"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="96"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN08885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="149" mass="15460" checksum="C854584F9BF89C17" modified="2018-04-25" version="1">MPSNDARILLQAVVPTAIAGALAAVISGVVAGGKGALGAVIGTVVVIVFMGLGQVVLQRTAKSLPQLFQAMGLMLYVAQLLLLLIFVAVFKDTTLFNPKAFAASLVAATVVWMAAQARAHMKAKIFYIDPDSAKDSEKSDKPENSGSSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JPX1</accession>
    <name>A0A2M9JPX1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Penicillin-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_25880</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000011">
        <property type="protein sequence ID" value="PJN08918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08918">
        <property type="protein sequence ID" value="PJN08918"/>
        <property type="gene ID" value="CG723_25880"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008658">
        <property type="term" value="F:penicillin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001460">
        <property type="entry name" value="PCN-bd_Tpept"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00905">
        <property type="entry name" value="Transpeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014676894" evidence="1">
        <location>
            <begin position="24"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="domain" description="Transpeptidase" evidence="2">
        <location>
            <begin position="155"/>
            <end position="480"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN08918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="488" mass="51447" checksum="9B54032BF13A66A9" modified="2018-04-25" version="1">MTRYIRRAAVFCLVLLVALLVNAARVQIFEADSLDDNPANRRNTITRYNQARGNILVDGKAVTGSKDSGEQLRYERTYKHGPLFAPVTGYASQMYGTSLLENAEDDILSGMDPMLAPLPLWNDLTRSQQPGGKVATTINGAAQRAAYSGLAGRRGAVAALNPATGAILALVSSPSYDPGKIAGTDSATMSAWTRLNRAPSQPMLNRAIRQTYPPGSTFKIVTAAAALDAGIVTDLDEPTETPSPWVLPDTSTVLRNEARGCEDASLADAIRVSCNTVMAKLGVQVGLKGMVSAARRFGFDDAGVRIPSSVSRSNFDTDMDRSQLALSSIGQFNTTATPLQMAMVSAAVVNGGVLMAPHLVDRTTDKNGNTLAQTGAKTYRQAMNPATATQLQEMMTDAVEDGTGTNAQIPDVMVGGKTGTAQHGVGNKGTPYAWFISWARSPEPGGPEVAVAVVVEDASANRTDISGGGSAAPIARNVMEAVLKSFHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JPX4</accession>
    <name>A0A2M9JPX4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_25810</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000011">
        <property type="protein sequence ID" value="PJN08906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08906">
        <property type="protein sequence ID" value="PJN08906"/>
        <property type="gene ID" value="CG723_25810"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014780110" evidence="2">
        <location>
            <begin position="28"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="107"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="108"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN08906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="260" mass="25873" checksum="25ABBEC8491B5F72" modified="2018-04-25" version="1">MLMLQKVVIAAATVGGLVALGSGSAYAANYSDSGHGGTRPFVAVGLSGDVTPQAQQPAEKKREALEKKASKGVNRTAAWQANARTRDILRTVGLPDGLLELPRQLAGTAGGKNQNNQVNGASGGVNQNNQAISASGGVNQNNQAISASGGVNQNNQVNGSSGGVNQNNQANGASGGVNQNNQANGSSGGVNQNNQANGSSGGVNQNNQANGASGGVNQNNQANGASGGVNQNNQVNGPRIAFAPAIQQLDLKQAQTVSGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JQ14</accession>
    <name>A0A2M9JQ14_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Na+/H+ antiporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CG723_26135</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CB01635</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Na(+)/H(+) antiporter that extrudes sodium in exchange for external protons.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000011">
        <property type="protein sequence ID" value="PJN08964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08964">
        <property type="protein sequence ID" value="PJN08964"/>
        <property type="gene ID" value="CG723_26135"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015299">
        <property type="term" value="F:solute:proton antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006814">
        <property type="term" value="P:sodium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006153">
        <property type="entry name" value="Cation/H_exchanger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018422">
        <property type="entry name" value="Cation/H_exchanger_CPA1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004705">
        <property type="entry name" value="Cation/H_exchanger_CPA1_bac"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10110">
        <property type="entry name" value="PTHR10110"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00999">
        <property type="entry name" value="Na_H_Exchanger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00831">
        <property type="entry name" value="a_cpa1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0050">Antiport</keyword>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0915">Sodium</keyword>
    <keyword evidence="5 6" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="1 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="29"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="82"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="108"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="181"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="221"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="266"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="299"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="344"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="379"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="domain" description="Na_H_Exchanger" evidence="7">
        <location>
            <begin position="8"/>
            <end position="402"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU366002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PJN08964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="532" mass="58034" checksum="4973D47D29A733F9" modified="2018-04-25" version="1">MDVLPLVALIAASAAVAGAARRTPVPAPLLLVAVGLVASYLPGVPHYTLDPHIVLPLILPPLLHTAALESSYLDLRANIRPVALLSVGYVLFATVSVGWLAYELIPDLPLTAALVLGAVIAPPDAVAATAIARKVGLPARITTILQGESLVNDATAITAYKVALAAAVGEGASWAGGIREFLVASVGGVGVGLVLMVPLHWLRRHLKEAILQNTLSLLIPFVAYAAAEQVGASGVLAVVTVALYLGHHAWQVDFETRLQEAAVWKVVAFILESAVFALIGLQLPFVLKDLGEYSVGEALGYAVAVFVLVVVMRFVWSYPATYLPWWLSARIRERERDTDWRRPLVVSWAGMRGVVSLAIAFSIPLFVDDGSRFPARNLVLFLTFTTVIGTLVVQGLSLPWLIKILKLPGRDTQAETLAEAQAQNAASQAAEERVNELMEDERNCLPEPLEDRLRTVLERRRNSVWERLGHANPVTGESADDTYRRLTREAIAAEREVFVRMRDERRIDDEMMRTLLRKLDLEEAAAYREVDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JQ60</accession>
    <name>A0A2M9JQ60_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Robl_LC7 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_25935</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000011">
        <property type="protein sequence ID" value="PJN08927.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08927">
        <property type="protein sequence ID" value="PJN08927"/>
        <property type="gene ID" value="CG723_25935"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004942">
        <property type="entry name" value="Roadblock/LAMTOR2_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03259">
        <property type="entry name" value="Robl_LC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00960">
        <property type="entry name" value="Robl_LC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Robl_LC7" evidence="2">
        <location>
            <begin position="25"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="54"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN08927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="167" mass="17205" checksum="A8C4C0CCF477A948" modified="2018-04-25" version="1">MTAPSRTPSASTPGFGLSTEARNLHWLLTNLVEEVPGLLSVAVVSSDGLLLLSSDPGRNNESPADHSGGPKGSSADLATIVSGIGSLTIGAAKLMDGGSVKQTMVAMEEGSLFVMSISDGSLLGVHATPDCDMSVVAYHMALFVGRAGHVLTPELRSELRQSMENAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JQP2</accession>
    <name>A0A2M9JQP2_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA helicase</fullName>
            <ecNumber evidence="2">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CG723_25100</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CB01635</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the helicase family. RAD25/XPB subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="2"/>
    <dbReference type="EMBL" id="NNBL01000010">
        <property type="protein sequence ID" value="PJN09189.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN09189">
        <property type="protein sequence ID" value="PJN09189"/>
        <property type="gene ID" value="CG723_25100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032438">
        <property type="entry name" value="ERCC3_RAD25_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006935">
        <property type="entry name" value="Helicase/UvrB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032830">
        <property type="entry name" value="XPB/Ssl2_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16203">
        <property type="entry name" value="ERCC3_RAD25_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13625">
        <property type="entry name" value="Helicase_C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04851">
        <property type="entry name" value="ResIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 7" id="KW-0347">Helicase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="5">
        <location>
            <begin position="189"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="6">
        <location>
            <begin position="397"/>
            <end position="545"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PJN09189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="550" mass="61007" checksum="AA0787DFA9B4EF7A" modified="2018-04-25" version="1">MNGPLIVQSDKTLLLEVDHDQADACRRAIAPFAELERAPEHIHTYRLTPLGLWNARAAGHDAEQVVDALVEYSRYPVPHALLVDIAETMDRYGRLTLSKHPAHGLVLTTTDRPVLEEILRSKRVAPLVGARIDADTVAVHPSERGQIKQTLLKLGWPAEDLAGYVDGEAHQIDLAEDGWALRPYQKQAVEGFWHGGSGVVVLPCGAGKTLVGAGAMAEAKATTLILVTNTVSARQWKHELVKRTSLTEDEIGEYSGTKKEIRPVTIATYQVLTTKRKGIYPHLELFDSRDWGLVIYDEVHLLPAPVFKFTADLQARRRLGLTATLVREDGRESDVFSLIGPKRFDAPWKEIEAQGYIAPADCVEVRVNLTDSERLAYATAEAEEKYRFCATTATKRKVTEALVRKHQGEQTLVIGQYIDQLDELGEHLDAPVIKGETSNAQREKLFDAFRNGEISVLVVSKVANFSIDLPEATVAIQVSGTFGSRQEEAQRLGRVLRPKADGHEARFYSVVARDTIDQDFAAHRQRFLAEQGYAYRIVDADELLAGEQGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JQQ4</accession>
    <name>A0A2M9JQQ4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_25170</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000010">
        <property type="protein sequence ID" value="PJN09203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN09203">
        <property type="protein sequence ID" value="PJN09203"/>
        <property type="gene ID" value="CG723_25170"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021391">
        <property type="entry name" value="DUF3027"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11228">
        <property type="entry name" value="DUF3027"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="264"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN09203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="307" mass="32352" checksum="A49BE641A71F71B9" modified="2018-04-25" version="1">MSAATTRSRTPDRLCAEAVGLARTAAEEAAAPGVVGEHVDVVVEGDRVVTHLFECKEFGYRGWRWAVTVARASRAKVVTLDETVLLPGPDALLAPEWVPWSERLRPGDMGPGDLLPTDAEDLRLEPGYSGEDVPPPNSAVSEEMAELVEAEDAELTVGPPAELPIAPERGSIASVAEELGMRRARVLSRYGLHIAADRWDEAYGAKTQMAQAAPATCVSCGFLARIGGSLGQAFGVCANEFSPADGRVVSLAYGCGGHSEAAVMPKPPRPAPHVIDETRVDPFPLRPSADSGSVPTTPDGTEDLGHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JR39</accession>
    <name>A0A2M9JR39_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="11">ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CG723_23600</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000009">
        <property type="protein sequence ID" value="PJN09328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN09328">
        <property type="protein sequence ID" value="PJN09328"/>
        <property type="gene ID" value="CG723_23600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221">
        <property type="entry name" value="PTHR24221"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="SSF90123"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="34"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="70"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="156"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="259"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="699"/>
            <end position="717"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="737"/>
            <end position="755"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="817"/>
            <end position="837"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="843"/>
            <end position="864"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="925"/>
            <end position="947"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="10">
        <location>
            <begin position="35"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="9">
        <location>
            <begin position="349"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="10">
        <location>
            <begin position="702"/>
            <end position="984"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="9">
        <location>
            <begin position="1018"/>
            <end position="1254"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="631"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="382"/>
            <end position="389"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="1053"/>
            <end position="1060"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PJN09328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="1278" mass="136406" checksum="65D0000E99C9DD65" modified="2018-04-25" version="1">MTDCPSQETSTPQQPWARWARRLLGYCLRHRADLLLAFGAAAVAAVATATLPLVLRHVVDGVAAGTTASLAPWTILLAGLGAVRFAAAFTRRYRSGRLSLGVQYDLRNDAFAALLRLGGAQQDDLRTGQVVSRSISDITLIQTLLQFLPNLTGNALMFLFSLVFMALLSPPLTVVALIVGPVLWLIALRSRRDLFPANWHAQMEAAEVASRVEATVTGVRVVKGFGQEARELTGLEERARRLFSSRLRVVRFTSRYNPALQAVPALGQVAVLALGGWMALHGRISLGTFLAFTTYLGSFVTPVRQVATLLTVWQQARAGAERVLEVVDEAPLITDAPGAQELPDRPAPLSWQNVTFGYGDGEPLLHGFTLDVRPGEAVALIGPAGSGKSTAAALLPRFYDVPSGSVRVGGVDVRDLTLESLRSRIGFVFEESLLLSDTVRANIAYGVPDATDEQIRAAAAIARADEFIERMPNGYDTVVGEQGLTLSGGQRQRLALARALVGDPAVLVLDDATSAIDARVEAEIHTRLREATRRRTTLIVAHRRSTLELADRIAVLDGGRITDTGTLDELLDRSALFRDLLSTGAATDAAEAAEAARAAPPPGEVTSHLWQRPAHFGRDTDEGAAVRAAQALAEAAATSGPGRGGPGGGVLSSAPPSPELIAALARLPLPPADPRVPTEEAVAADPAFHLGTLLRPFRLPLLLGLLLVALDAVAQIAVPVLVRHGVDHGVARHAGDILLAAAAAAGLVVAGNWLIGVAQVRTTGRTGERLLYTLRVKTFAQLQRLGLDYYERELGGRIMTRMTTDVDALSNFLQTGLITAVVSLLTILGVLLTLLIIDAGLAAVLLAVLPLLAGATVLFQHYSVPAYREARERISAVNACLQENVTAIRVTQAFRREQRNARDFARLAWAFRDSRLRAQRYMGTFFPFVEFLGTLSTAAVLVVGAGHVRSGELSGGTLIAFLLYVELFFSPIQQLSQVFDGYQQAVVGLGRLRALMQTPAGTPPAEHPLPVEKLRGEIEFDGVSFGYPGGGGREVLHGLCLSIAPGETVALVGATGAGKSTVVKLLARFYDPTAGTVRVDGHDLRDLDLTGLRRRLGVVPQEPHLFSGTVRDAIAYGWPEATRAEVEAAARAVGAHEMVAGLPLGYLQPVGERGRNLSAGQRQLLALARAELVDPDVLLLDEATASLDLATERRVAAATEALARRRTTIVVAHRLTTAARADRVVVLDAGAVVEDGTHAGLLAARGPYHQLWQAFQQGGHPASVDHLKINELVKENAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JR40</accession>
    <name>A0A2M9JR40_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NADPH:quinone reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_23725</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000009">
        <property type="protein sequence ID" value="PJN09346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN09346">
        <property type="protein sequence ID" value="PJN09346"/>
        <property type="gene ID" value="CG723_23725"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="PKS_ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002364">
        <property type="entry name" value="Quin_OxRdtase/zeta-crystal_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01162">
        <property type="entry name" value="QOR_ZETA_CRYSTAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PKS_ER" evidence="1">
        <location>
            <begin position="10"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN09346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="331" mass="35355" checksum="544AF14B48ABF39C" modified="2018-04-25" version="1">MRAVRLHEHGGPEVLRYDEVPTPEPGPGEVLVRVHAVGINPPDWYLRDGMSNLPPKVRPKFSLPVIPGTDLSGVVEAIAPDVDDFSVGDEVFGLLRFPGFDGSTYAEYVAAPASDLALKPAGIDHVHAAGAPMAGLTAWQFLIELGHDHPSPFQTAQHRPVPLDANMTVLVNGAAGGVGHFALQLAKWKEARVIAVASGAHEVFLRELGADEFIDYTKSRPEELVHDVDLVLDAVGGPDSKRFLRTLKRGGSQFPVFFGEFDEEETAKLGVTVTGTQVRSNGAQLAALGRLLDAGTVRVAIDSTFALADARAAHERAARGHIQGKVVLTVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-05-25" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JRS2</accession>
    <name>A0A2M9JRS2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">LacI family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CG723_22635</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000008">
        <property type="protein sequence ID" value="PJN09542.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN09542">
        <property type="protein sequence ID" value="PJN09542"/>
        <property type="gene ID" value="CG723_22635"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01392">
        <property type="entry name" value="HTH_LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000843">
        <property type="entry name" value="HTH_LacI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046335">
        <property type="entry name" value="LacI/GalR-like_sensor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00356">
        <property type="entry name" value="LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13377">
        <property type="entry name" value="Peripla_BP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00036">
        <property type="entry name" value="HTHLACI"/>
    </dbReference>
    <dbReference type="SMART" id="SM00354">
        <property type="entry name" value="HTH_LACI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50932">
        <property type="entry name" value="HTH_LACI_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="6">
        <location>
            <begin position="24"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="domain" description="HTH lacI-type" evidence="5">
        <location>
            <begin position="26"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PJN09542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="357" mass="37848" checksum="AA6CEEF7CB4D6230" modified="2018-04-25" version="1">MEVGNVARVGGRGKAATQSPDGPAKVTITEIAREAGVSVPTVSRVVNGRSDVSPATRARVEDLLQRHGYQRRPPAPGDRAALLDLVFNDLDSPWAVEIIRGVEEVAHEAGVGTVVSAIHDRAGAARQWMTNLRARASDGVILVTSVLEPGLHDELRRLGVPLVVVDPAGSPATEAPTVGATNWAGGMAATEHLLGLGHRRIGFIEGPPRLLCSRARLDGYRAALDVAGVPVDDALIVPGDFYHESGFTGCNQLLDLVEPPTAIFASSDQMALGAIEALRRRGLRVPEDMSVLGFDDLPEVRWSAPPLTTVRQPLAEMGKLAARFVLDLARSVAPASSRVELATELVVRASTGEPRQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JSI4</accession>
    <name>A0A2M9JSI4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CG723_21835</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000007">
        <property type="protein sequence ID" value="PJN09834.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN09834">
        <property type="protein sequence ID" value="PJN09834"/>
        <property type="gene ID" value="CG723_21835"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PJN09834.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="689" mass="76018" checksum="B13A0D1A17227F63" modified="2018-04-25" version="1">MDLDALRYGNFSALGEAVGDWEEMVVNLKSLQDDAERDLKAKADRANWHGANATVSREFVDKTAGEFADAHTQANSIAKILGDTRSELIDYRQQLNDAIDRGMKKNLTVVDTGNGGFTVTMNIHPDRAAKGTEVPDHSPQDVTGLRDEVQRILSGATESDNTAAKTLNLIVDQATYGFSGADYSDRDAAAKAVKEADDLANLMKNKGDDMTPAEFDRLNASMAKYKNDPLFQEEFAKTLGPKGTLDFWADLSDPSDGGDLQRARRDQLGDFQKNLGMTLAGATQSDSADMQSWKDRMVDLGGQTVQTRGSNVYGFQLMSNIMRTGNYDDDFVNKYGNALVATEKKMKLPDHYWQGAGGPPMPKMNFIGEDFGRDPMTGFMTGLSNSPDAATEFFNETHPQDNAEWVLKERHTFDDTPLDDGDGNQSRDATGRALLAATSGMNPNDPNATYVEHTPENRQALDRSLKYLSETGDDFPHEMRDDMAKVLVNYGDETHNTMSSQADHPDDPRQLDRHQLLEVTKQISRDQDSYGLLNDGLNREIVHDINTDHPSDPKETLQRAGATVGFLEEARYQALDTDKEDPSWKAKWAYHGIGGAVNFIPVVGDAAQRGVDALTYQWQQDEQGRIDDQNHQQNGKTFTGREGQLESLAKIWATANPGQTENNSYTLTNEINAAAFDGNARARGLAGDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JSM2</accession>
    <name>A0A2M9JSM2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PucR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_20800</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000007">
        <property type="protein sequence ID" value="PJN09848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN09848">
        <property type="protein sequence ID" value="PJN09848"/>
        <property type="gene ID" value="CG723_20800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2840">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025736">
        <property type="entry name" value="PucR_C-HTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042070">
        <property type="entry name" value="PucR_C-HTH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13556">
        <property type="entry name" value="HTH_30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH_30" evidence="1">
        <location>
            <begin position="325"/>
            <end position="383"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN09848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="386" mass="41084" checksum="54109F78691E55C3" modified="2018-04-25" version="1">MKGDYQELVDEISALLSAPATLENRDFGLIAFGAQDSDSEFDESTLDPVRTRSILTRRSTAAVRTWFEGFGIARATGPVRIPPTPEAGVYRGRICLPVRHRGVVLGYVWLIDDDPGPTEQQLTAAMEVAGRIGALLADEAQAGADLTREFREVLTAERGWQRDMAVAALRTALGSRADGLHAVVCVAPWPSADPDDAPSFRTIPAADALCMVPWGAAGQALALLVRLRSADALGPASAAAAKLRERAGTAVVAAGFAGARRELGDLGAAWQEATAAARAALAEPRLGPDAHWAAIGPYRLLTALPPDTAHDPVLAPLLLPANRQLARTTEVFLDCAGQAGRTAAELGIHRQTLYYRLSRVEQLTGLDLDDGEDRLLLHMGLKASRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JT74</accession>
    <name>A0A2M9JT74_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">50S ribosomal protein L11</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6 11" type="primary">rplK</name>
        <name evidence="11" type="ORF">CG723_20465</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CB01635</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6 8">Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Part of the ribosomal stalk of the 50S ribosomal subunit. Interacts with L10 and the large rRNA to form the base of the stalk. L10 forms an elongated spine to which L12 dimers bind in a sequential fashion forming a multimeric L10(L12)X complex.</text>
    </comment>
    <comment type="PTM">
        <text evidence="6 8">One or more lysine residues are methylated.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6 7">Belongs to the universal ribosomal protein uL11 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000006">
        <property type="protein sequence ID" value="PJN10085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN10085">
        <property type="protein sequence ID" value="PJN10085"/>
        <property type="gene ID" value="CG723_20465"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070180">
        <property type="term" value="F:large ribosomal subunit rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00349">
        <property type="entry name" value="Ribosomal_L11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.250">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00736">
        <property type="entry name" value="Ribosomal_L11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000911">
        <property type="entry name" value="Ribosomal_L11/L12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036796">
        <property type="entry name" value="Ribosomal_L11/L12_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006519">
        <property type="entry name" value="Ribosomal_L11_bac-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020783">
        <property type="entry name" value="Ribosomal_L11_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036769">
        <property type="entry name" value="Ribosomal_L11_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020785">
        <property type="entry name" value="Ribosomal_L11_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020784">
        <property type="entry name" value="Ribosomal_L11_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11661">
        <property type="entry name" value="PTHR11661"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00298">
        <property type="entry name" value="Ribosomal_L11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03946">
        <property type="entry name" value="Ribosomal_L11_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00649">
        <property type="entry name" value="RL11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46906">
        <property type="entry name" value="SSF46906"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54747">
        <property type="entry name" value="SSF54747"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01632">
        <property type="entry name" value="L11_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00359">
        <property type="entry name" value="RIBOSOMAL_L11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0488">Methylation</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6 7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 6 7" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3 6 8" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 6 8" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="Ribosomal_L11_N" evidence="10">
        <location>
            <begin position="12"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="domain" description="Ribosomal_L11" evidence="9">
        <location>
            <begin position="74"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010537"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00736"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF03946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PJN10085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="144" mass="15182" checksum="F659407D34B31B84" modified="2018-04-25" version="1">MPPKKKKVTGLIKLQIQAGAANPAPPVGPALGQHGVNIMEFCKAYNAATESQRGWVIPVEITVYEDRSFTFITKTPPAAKMILKAAGIEKGSGEPHKTKVAKITDAQVREIATTKMADLNANDLDAAAKIIAGTARSMGVTVEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-05-25" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JTE7</accession>
    <name>A0A2M9JTE7_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 5">30S ribosomal protein S17</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">rpsQ</name>
        <name evidence="6" type="ORF">CG723_20285</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CB01635</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Part of the 30S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 3 4">Belongs to the universal ribosomal protein uS17 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000006">
        <property type="protein sequence ID" value="PJN10057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN10057">
        <property type="protein sequence ID" value="PJN10057"/>
        <property type="gene ID" value="CG723_20285"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01345_B">
        <property type="entry name" value="Ribosomal_S17_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019984">
        <property type="entry name" value="Ribosomal_S17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000266">
        <property type="entry name" value="Ribosomal_S17/S11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019979">
        <property type="entry name" value="Ribosomal_S17_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10744">
        <property type="entry name" value="PTHR10744"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00366">
        <property type="entry name" value="Ribosomal_S17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00973">
        <property type="entry name" value="RIBOSOMALS17"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03635">
        <property type="entry name" value="uS17_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00056">
        <property type="entry name" value="RIBOSOMAL_S17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 4 6" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3 5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 3 5" id="KW-0699">rRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PJN10057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="94" mass="10633" checksum="2D0BA1EC7C471C36" modified="2018-04-25" version="1">MSESNVTEETAARGFRKTREGLVVSDKMDKTVVVAVEDRVKHALYGKVIRRTNKLKAHDEQNAAGVGDRVLIMETRPLSATKRWRIVEILEKAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-09-29" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JTY0</accession>
    <name>A0A2M9JTY0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ferredoxin-NADP reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CG723_18390</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000005">
        <property type="protein sequence ID" value="PJN10345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN10345">
        <property type="protein sequence ID" value="PJN10345"/>
        <property type="gene ID" value="CG723_18390"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00037">
        <property type="entry name" value="Fer4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="4">
        <location>
            <begin position="37"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PJN10345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="553" mass="58738" checksum="EB22271B6E9F2517" modified="2018-04-25" version="1">MTYAITQTCCSDATCVAVCPVNCIHPTPEERAFGSTEMLHIDPVSCIDCGACADACPVDAIFPVDRLAPEQKEYAAINAAYFEHRDRHTDSGTDAVEDGPTFHAWGSPSFPRVLPSDLAPLRIAVVGTGPAGMYAVQDLLLHTNAEVTLIDRLPVAGGLVRYGVAPDHPATKKVGETFARFHTHHRVRMHLGLEVGDDVTAQELAEHHDAVVYAVGAAADRRLSVPGEDLTGSISARTFVAWYNAHPDVAHEAIDLSAERVVVVGNGNVALDVARILLADPDTLARTDIADHALKALRASSVREVVLLGRRGPEDAAYTTPELLALKHVPGLQLLVDDHDPRIAAAIDEAGPKDRAAVLKGVPRGGFDGDVAPPPGRRIVLRFHSSPVELLGSEQIEAVRTDGVSGERVIAAGMVLRAIGYRGGPLSGLPFDEATGTVPHEGGRVTGMPGTYVVGWIKRGPSGGIGANRTCAAETVATLLADAVSGALPTPPHAPKAFHRLVRRRNRRVLDAKGLAAIERAEAARGREAGRPRVKLATVDELVASARRRRVLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JU61</accession>
    <name>A0A2M9JU61_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">TetR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_18765</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000005">
        <property type="protein sequence ID" value="PJN10403.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN10403">
        <property type="protein sequence ID" value="PJN10403"/>
        <property type="gene ID" value="CG723_18765"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="3"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="26"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN10403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="205" mass="21704" checksum="213B2E4657027E68" modified="2018-04-25" version="1">MGADRLDEVLDATYDCLTRYGVRRTTMDDIASTMGVSRSAVYQYVRNKDDAFRRLAERQHTQALGRARRAAAEDSPLAERVRGVLAAKLDLVLRLAGDSPHSAELLDAKARLFADICHTFTADLRRLLTGLFTEAGTPAAVEPAEAADICIALVVGLESVSDARQLFTPATDALLAGLLGGPVSVCTSRVTTPGGAPPGSATHPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-05-25" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JUK1</accession>
    <name>A0A2M9JUK1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">LacI family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CG723_19070</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000005">
        <property type="protein sequence ID" value="PJN10457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN10457">
        <property type="protein sequence ID" value="PJN10457"/>
        <property type="gene ID" value="CG723_19070"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01392">
        <property type="entry name" value="HTH_LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000843">
        <property type="entry name" value="HTH_LacI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046335">
        <property type="entry name" value="LacI/GalR-like_sensor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00356">
        <property type="entry name" value="LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13377">
        <property type="entry name" value="Peripla_BP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00354">
        <property type="entry name" value="HTH_LACI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50932">
        <property type="entry name" value="HTH_LACI_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH lacI-type" evidence="4">
        <location>
            <begin position="3"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PJN10457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="340" mass="35954" checksum="C54EB4CF90777CD3" modified="2018-04-25" version="1">MTRRLAQVAQKVGVSEATVSRVLNNKPGVSEATRQAVLTALDVLGYERPTQLRGERARLVGLVLPELQNPIFPAFADVIGGALAQQGLTPVLCTQTNGGVSEADYVELLLQQQVSGVVFAGGQFAQADARHEHYRLLSERKVPVVLVNAAIEDLGFPCVACDDAVAVEQAWRHLSSLGHERIGLVLGPDDHVPSMRKLAAARGVVRAAGGTLPEDAVERAMFSLEGGHAAAARLMRRGITGIICASDPLALGAVRAARREGLRVPDEISVVGYDDSAFMNCTEPPLTTVRQPIEAMGRAAVELLVTQIQGGSVTPGELLFEPELVVRGSTAQAPSRTAVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JUX4</accession>
    <name>A0A2M9JUX4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_15765</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000004">
        <property type="protein sequence ID" value="PJN10664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN10664">
        <property type="protein sequence ID" value="PJN10664"/>
        <property type="gene ID" value="CG723_15765"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="116"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN10664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="141" mass="15619" checksum="0513D46DCC71EAB0" modified="2018-04-25" version="1">MDAVFHILFPVLILVLVWAGYAIVRRSNQRQAAWQSGLTARARVVRAYVTVQVVNNIARRIQWHEYDFTTADRRAIRFKESGGPPSRAAGDEAVVYYTVQQPDKATASEPSPGKDAFGMIFGLVVIVATIGILINVVIQYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JV93</accession>
    <name>A0A2M9JV93_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_16530</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000004">
        <property type="protein sequence ID" value="PJN10784.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN10784">
        <property type="protein sequence ID" value="PJN10784"/>
        <property type="gene ID" value="CG723_16530"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="33"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="66"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="106"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="148"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="175"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="217"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="244"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN10784.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="458" mass="48854" checksum="F650EB4C9E63B7B7" modified="2018-04-25" version="1">MTADVQAPATAPPAPKAPGRPHHPLRAELLRGFAPWSGLAALLSVGGLMAAKAAQWQGSWPETMSNLHLTAAALAVPLALAAGAWQGGRERRTRMGELRASMPRGPLAQFLVCALPVALWVMGGYALAAVGSLLAGLPYTSAGHPLPLVLLGDALTVGACALLGHVAGRTVPWRLAAPVLALGGYVLFGLASTADSAVRFVGPAGGFPLGSTTVPVWWQPLVFALWGSALALTAVLAHAARRRATALVPLVAALAAATVLVQSGESMWQRNPLTQRQVCDDSTPRVCVSAAYPGMLPKVSDALSGLMGRLDGVQNLPVRFEDLPRRPHEDEAELPMLTPIGWGVVRGELTDPQQYAWEAAHKLVREDCPVLKAQDARIARTDQAVTRWLAPSRLQEQIRDQNLVVHRGDKKRLAEDRADEAALDHLKAMSPETRRAWLTRYFATARDCAPDPREVPSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JVG9</accession>
    <name>A0A2M9JVG9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CG723_16960</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000004">
        <property type="protein sequence ID" value="PJN10859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_016643127.1">
        <property type="nucleotide sequence ID" value="NZ_NNBL01000004.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN10859">
        <property type="protein sequence ID" value="PJN10859"/>
        <property type="gene ID" value="CG723_16960"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PJN10859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="77" mass="8973" checksum="DBF3CD05E35DDE2A" modified="2018-04-25" version="1">MGAHRRKCDWCGSGTPIVRDMEPVNPDYQYWCEECARALIIKGDPIETYRELEGEPIYGRLLDEHCTLKRFYSFATA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JVK6</accession>
    <name>A0A2M9JVK6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Ectoine/hydroxyectoine ABC transporter permease subunit EhuD</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">ehuD</name>
        <name evidence="8" type="ORF">CG723_15810</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CB01635</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000004">
        <property type="protein sequence ID" value="PJN10926.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN10926">
        <property type="protein sequence ID" value="PJN10926"/>
        <property type="gene ID" value="CG723_15810"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006865">
        <property type="term" value="P:amino acid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010065">
        <property type="entry name" value="AA_ABC_transptr_permease_3TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043429">
        <property type="entry name" value="ArtM/GltK/GlnP/TcyL/YhdX-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014341">
        <property type="entry name" value="Ectoine_EhuD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30614">
        <property type="entry name" value="PTHR30614"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03003">
        <property type="entry name" value="ectoine_ehuD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01726">
        <property type="entry name" value="HEQRo_perm_3TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="86"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="194"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="7">
        <location>
            <begin position="24"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PJN10926.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="221" mass="24463" checksum="E4B0CF5D3126BBDE" modified="2018-04-25" version="1">MTTASDTWDWSAVADFMPHFWDGVLVTLQALVLGSLISFSVGLVWALALRAPTRSVRWPVGVVTEFIRNTPLLVQLFFLYFVLPEWGIQFSALTTGIVAIGLHYSTYTAQVYRAGIEAVPVGQWEAARALSLPYGRTWTAVILPQAIRRVIPALGNYVIAMLKDTPLLAGIGVLELLQRSRLEAAQTFQYTEALTVVGVAFIVIAYPSSLLLRALERRLVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JVM4</accession>
    <name>A0A2M9JVM4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CG723_16345</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000004">
        <property type="protein sequence ID" value="PJN10945.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN10945">
        <property type="protein sequence ID" value="PJN10945"/>
        <property type="gene ID" value="CG723_16345"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001737">
        <property type="entry name" value="KsgA/Erm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11727">
        <property type="entry name" value="PTHR11727"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PJN10945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="207" mass="22486" checksum="B560045653758666" modified="2018-04-25" version="1">MTLFLREFARTRRDTGAIVPSSPLLARALTRHVIPSPGRARAVLEVGPGTGAVTRRIRASLGALDTLDLVEANARFAELLHRDYGGDERVRLLTGLVQEHDLGSYDTIVYGLPFANFDAGTVEDIFGRLLAALRPGGTLSFFAYAGMPRLRRVFTTGGARERTLAVQAVVGRTLDRHRFRTETVLGNLPPAHVHHLAPVAPLLAYAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-09-29" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JVY5</accession>
    <name>A0A2M9JVY5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CG723_08805</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN11063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN11063">
        <property type="protein sequence ID" value="PJN11063"/>
        <property type="gene ID" value="CG723_08805"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1610.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010318">
        <property type="entry name" value="DUF917"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024071">
        <property type="entry name" value="DUF917_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027479">
        <property type="entry name" value="DUF917_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06032">
        <property type="entry name" value="DUF917"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PJN11063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="354" mass="36931" checksum="35E9E42709C71DD6" modified="2018-04-25" version="1">MKRQLTHDDIRAAVYGGAVLGGGGGGFVERGLRTADLALQVGAPELWTADEFAADDLTATVALVGAPAAPDPQVLPTHLLRALELLRRDLPRELVAIHTNENGAETTINGWFHSAMTGLPVIDLACNGRAHPSSQMGAMGLHARDGYRSYQGYAGGKPYAYVEGAVSGTLDATSNVVRRASVEAGGWVGVARNPVEVGYAVQNGAPGAISFAIELGHRFLGNGPAGAAGHLGGEIAVTGTVREYRCEQREGLDVGVAVLDDAEGTTLHFVNEYMAFEAGGERKASFPDLITTFDEAGQPLASADVEVGKQISVLVAPAENLQLSTTMFMPEVYAPVEALLGIEFAPVAKILADA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JW62</accession>
    <name>A0A2M9JW62_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Neuraminidase (Sialidase)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_09015</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN11099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN11099">
        <property type="protein sequence ID" value="PJN11099"/>
        <property type="gene ID" value="CG723_09015"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004308">
        <property type="term" value="F:exo-alpha-sialidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026856">
        <property type="entry name" value="Sialidase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036278">
        <property type="entry name" value="Sialidase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10628">
        <property type="entry name" value="PTHR10628"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50939">
        <property type="entry name" value="SSF50939"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014818977" evidence="1">
        <location>
            <begin position="29"/>
            <end position="490"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN11099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="490" mass="52874" checksum="FB7C39570C94AD1F" modified="2018-04-25" version="1">MRVFLPLTAVTTAALLLVTVTGATPAAADRNPDGTPLVKVSHGDPYADCTIGARSPDSIVYPATEVEPYLSVDPRDPKRVVTVFQQDRWNDGGARGLAAGWTKDGHTFHRSTLPFSLCAPGGADFERASDPWVSTGPDGTVYASGEGVDFTKSTRSALLAATSRDGGRTWRNLTTTHVDKQPFFNDKPSLTADPIRKGTAYQVWNRLDNNPPGSSSLDGPGYISLTRDGGRTWSKARPFVDTSTVPNTQTIGHVIVADRRTGTLYDFFDRITYSDDLSTVIEAHYEMVTSTDAGETWSAPATVARDTSVPEVDPNDPTKLLRAAATLPSPAVDPKTGRLYMAYEGSDFSGGRFDSVQLVRSTDGGRTWGTPELISPEGVPAFSPSIAVAERGTVALTYYDLRFLKPGDTTTLPTAYQLATLPHGDPKLQTERRISRVFDWLQAPFAGGYFLGDYQGLVAAGKGVRAVLTETHSGAPRNRTDVYTSSLRTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JW66</accession>
    <name>A0A2M9JW66_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Peptidase M23</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CG723_09215</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN11130.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN11130">
        <property type="protein sequence ID" value="PJN11130"/>
        <property type="gene ID" value="CG723_09215"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011094">
        <property type="entry name" value="Uncharacterised_LppY/LpqO"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07485">
        <property type="entry name" value="DUF1529"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PJN11130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="334" mass="35258" checksum="F953D104A0233C6F" modified="2018-04-25" version="1">MVSSRHGGDQMMTGDKQAATSRRRVLTAAALAPVLAGAGPASARAMPDAALVKPLTTTASDWAAVAKALGRSGNLLRGTTYHTPFPRDDLRVVVEGNVVITPELALGAHVAFVRYADGSTMCMGDVAVTERELQRVIDAWQANGIAQTALHKHLPTHRPDIWWVHVHGHGHDELALAHGLRAGFDRTGIPPATPSVPPSPVDLDMAAIDAALGAKGSSDGVVYKAVFARRETICDGHLVLPSGLGATSAFIFQPLGNGRAALSGDCVMLAEEVQNVLGALRRGRIKLVELHNHHLTESPRLFFTHFWAVGDAVELAKALRPAVDATNVVPTSGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JWU9</accession>
    <name>A0A2M9JWU9_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Hercynine oxygenase</fullName>
            <ecNumber evidence="1">1.14.99.50</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Gamma-glutamyl hercynylcysteine S-oxide synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">egtB</name>
        <name evidence="4" type="ORF">CG723_10440</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CB01635</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the oxidative sulfurization of hercynine (N-alpha,N-alpha,N-alpha-trimethyl-L-histidine) into hercynyl-gamma-L-glutamyl-L-cysteine sulfoxide, a step in the biosynthesis pathway of ergothioneine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>gamma-L-glutamyl-L-cysteine + hercynine + O2 = gamma-L-glutamyl-hercynylcysteine S-oxide + H2O</text>
            <dbReference type="Rhea" id="RHEA:42672"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:15781"/>
            <dbReference type="ChEBI" id="CHEBI:58173"/>
            <dbReference type="ChEBI" id="CHEBI:82703"/>
            <dbReference type="EC" id="1.14.99.50"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; ergothioneine biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the EgtB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.99.50" evidence="1"/>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN11339.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN11339">
        <property type="protein sequence ID" value="PJN11339"/>
        <property type="gene ID" value="CG723_10440"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA01014"/>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044875">
        <property type="term" value="F:gamma-glutamyl hercynylcysteine sulfoxide synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02035">
        <property type="entry name" value="EgtB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024775">
        <property type="entry name" value="DinB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034660">
        <property type="entry name" value="DinB/YfiT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017806">
        <property type="entry name" value="EgtB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032890">
        <property type="entry name" value="EgtB_Actinobacteria"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005532">
        <property type="entry name" value="SUMF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042095">
        <property type="entry name" value="SUMF_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12867">
        <property type="entry name" value="DinB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03781">
        <property type="entry name" value="FGE-sulfatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109854">
        <property type="entry name" value="SSF109854"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="SSF56436"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03440">
        <property type="entry name" value="egtB_TIGR03440"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0408">Iron</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DinB_2" evidence="3">
        <location>
            <begin position="23"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="domain" description="FGE-sulfatase" evidence="2">
        <location>
            <begin position="181"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="region of interest" description="Gamma-glutamylcysteine binding" evidence="1">
        <location>
            <begin position="93"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="59"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="145"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="149"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="424"/>
        </location>
        <ligand>
            <name>gamma-L-glutamyl-L-cysteine</name>
            <dbReference type="ChEBI" id="CHEBI:58173"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="428"/>
        </location>
        <ligand>
            <name>gamma-L-glutamyl-L-cysteine</name>
            <dbReference type="ChEBI" id="CHEBI:58173"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PJN11339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="444" mass="49672" checksum="9E081F2EB1754E63" modified="2018-04-25" version="1">MTAQSEDTAPDPEALRERARTALLTARDRTTLLTSCVEGPELTAQHSPLMSPLVWDLAHIGNQEEQWLLRAVAGREAMRPEIDPLYDAFEHPRSERPKLPLLAPKEARGYAAEVRGRALDVLESTPFHGTRLTEAGFAFGMIAQHEQQHDETMLITHQLRSGAPALTAPDPDPVSPAFRGPSEVLVPGGPFTMGTTAEPWSLDNERPAHARLVPPFHIDTAPVTNAAYLAFMEDGGYDNSRWWTPEGWALVRDNGLRSPLFWRREAGQWLRRRFGVTEVVPPDEPVVHVSWYEADAYARWAGRRLPSEAEWEKAARFDPASGRSMRYPWGDADPTPERANLGQRHLRPAPAGSYPAGESPLGVRQLIGDVWEWTSSDFLPYPGFVAFPYREYSEVFFGPDHKVLRGGSFAVDAVACRGTFRNWDYPVRRQIFAGFRTARDGEGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JX27</accession>
    <name>A0A2M9JX27_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Taurine catabolism dioxygenase TauD</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CG723_11080</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN11445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN11445">
        <property type="protein sequence ID" value="PJN11445"/>
        <property type="gene ID" value="CG723_11080"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042098">
        <property type="entry name" value="TauD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003819">
        <property type="entry name" value="TauD/TfdA-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02668">
        <property type="entry name" value="TauD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TauD" evidence="4">
        <location>
            <begin position="44"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="299"/>
            <end position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PJN11445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="348" mass="37937" checksum="72CD74F1DAACF565" modified="2018-04-25" version="1">MWRGRDLAASRAWALHLSPARLDELDAALRTVRARGTPVLKVTAGDFPLPTLAGELRSAADELENGRGFVLVRGIPVERYSEEAAGVLLWGVGQHLGIPVSQDATGHMLRHLRDAPDARAALSPRTEAADALALLCLRADGSSGRTTLASSAAVHNAVLARRPELLDGLSRTHFLDRRGEQLPGQLPWQALPLAHRDGERLSLRYDRGRLESAQRFPEVPRLGSADRELFDLMDEAASSPELRLDIDLAPGDLLLLNNHAALHACAPHDEDGPQREQPWHLLQLWLTPHQSRPLPAEFWGGERSGTGGRGGVTPRDVITPHTPHTPTKGKQPHVRPLRTPGAFGPVPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JXA0</accession>
    <name>A0A2M9JXA0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Amidohydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_11475</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN11514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN11514">
        <property type="protein sequence ID" value="PJN11514"/>
        <property type="gene ID" value="CG723_11475"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01979">
        <property type="entry name" value="Amidohydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="SSF51338"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydro-rel" evidence="1">
        <location>
            <begin position="59"/>
            <end position="390"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN11514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="400" mass="41814" checksum="6BCCE4D27B62435E" modified="2018-04-25" version="1">MSSRKLITAARVVTGPGGRCVEDGAVLTDGDTVVAAGRRSDVEALADERDERIALPGTTVLPGLVDAHVHLVFDAGTDPVGTLEGQDDDALLAVMRERAARLVASGVTTVRDLGDRGRLTLRLREEIESGAVPGPRIVAATTPVTPEGGHCWFLGGEVGSERELRDLVRRNAELGADVIKVMATGGALTRGGPATWQAQFGAGELAVVVEEAHGAGLPVAAHAHGTAGIEAAVTAGVDTLEHCTWMTEDGNDLRDDVLDAIVERGIRVCPTVSPHWRMLPTVFGAERAERLFGQVRTMAERGVRFIAGTDAGVQRAGFDGLRPSLTFFEHIGMPAPRVIDMATTEAADALGAGGRAGLLAPGRPADLIAVGSDPRAGLEALADLRFVMSRGELIPPQRAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JXH6</accession>
    <name>A0A2M9JXH6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_11900</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN11586.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN11586">
        <property type="protein sequence ID" value="PJN11586"/>
        <property type="gene ID" value="CG723_11900"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000551">
        <property type="entry name" value="MerR-type_HTH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13411">
        <property type="entry name" value="MerR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00040">
        <property type="entry name" value="HTHMERR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00422">
        <property type="entry name" value="HTH_MERR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="SSF46955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50937">
        <property type="entry name" value="HTH_MERR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH merR-type" evidence="1">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN11586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="213" mass="23572" checksum="C270400650E1A676" modified="2018-04-25" version="1">MRLAELSELSGVSIPTIKYYLREQLLPAGRRITATQAEYDDSHLRRLRLVRALIQVGRVPVATAREVLAAVDDDSLGRTVRLGAALWALPQPPEAPGDDPATVEATSAVDRLLEELGWDTAREIGSLSPSYRTLVTTVATLNRLGYTCGTPELAPYARHMERVAEHDIDRLDTFSEEVEKVEIAVAAAILYEPVLLTLRRLAQEEQSARRFGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JXI5</accession>
    <name>A0A2M9JXI5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">MarR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_11955</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN11595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN11595">
        <property type="protein sequence ID" value="PJN11595"/>
        <property type="gene ID" value="CG723_11955"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000835">
        <property type="entry name" value="HTH_MarR-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01047">
        <property type="entry name" value="MarR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00347">
        <property type="entry name" value="HTH_MARR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50995">
        <property type="entry name" value="HTH_MARR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH marR-type" evidence="2">
        <location>
            <begin position="17"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="88"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="88"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN11595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="154" mass="16991" checksum="E695B1C6DFF3B0F1" modified="2018-04-25" version="1">MNNAEGIDHAEVISESADRAARELRVMFSRLRRRLREVSDSQDLTPSQVSALNRLSKAEAATASGLAAAEGVRPQSMAATLAALDQRGLIERRPDPEDGRRQLVTLTDAGRESAEGTRQARGEWLARTFQDGYSEEERRTIVTALTLLERLTEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JXQ5</accession>
    <name>A0A2M9JXQ5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GntR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_11710</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN11557.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN11557">
        <property type="protein sequence ID" value="PJN11557"/>
        <property type="gene ID" value="CG723_11710"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07377">
        <property type="entry name" value="WHTH_GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1410.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028978">
        <property type="entry name" value="Chorismate_lyase_/UTRA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011663">
        <property type="entry name" value="UTRA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
        <property type="entry name" value="GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07702">
        <property type="entry name" value="UTRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00035">
        <property type="entry name" value="HTHGNTR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00345">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00866">
        <property type="entry name" value="UTRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64288">
        <property type="entry name" value="SSF64288"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50949">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH gntR-type" evidence="1">
        <location>
            <begin position="7"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN11557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="257" mass="28268" checksum="A3840C087801B93A" modified="2018-04-25" version="1">MKTSKGVPLHEKLGAEFLRRIESGEWPEGEPVPSESQLCEEFGTSRGPVRQALSILRSDGHLVGGRGKPPVARRAAPSQPFASLMSFTQWARSIGREPGQLTVEVARRRASPEAAARLGLDEGEPVVDLVRLRHLDGVPVMVERSTFVLHVGRHLFDMDPDAGSIYEALCARDVDLHHARHTIDAIAADTQDASLLGIEPGEPLLRVRRLALSRDGVPLEYADDRYLPTLANFTIENTAEGRTVVGRYRTDEENPSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JYL3</accession>
    <name>A0A2M9JYL3_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Transport permease protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CG723_14205</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CB01635</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the ABC-2 integral membrane protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN11964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN11964">
        <property type="protein sequence ID" value="PJN11964"/>
        <property type="gene ID" value="CG723_14205"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046677">
        <property type="term" value="P:response to antibiotic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC_2_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000412">
        <property type="entry name" value="ABC_2_transport"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01061">
        <property type="entry name" value="ABC2_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006648">
        <property type="entry name" value="DrrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00164">
        <property type="entry name" value="ABC2TRNSPORT"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51012">
        <property type="entry name" value="ABC_TM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0046">Antibiotic resistance</keyword>
    <keyword evidence="8" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="95"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="145"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="171"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="208"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="260"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="domain" description="ABC2_membrane" evidence="9">
        <location>
            <begin position="40"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PJN11964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="283" mass="30067" checksum="B6C8ED1E6CEA730A" modified="2018-04-25" version="1">MSAAPAAPRQGSADPGEFDLLLTPPTARTGWRVAPARVVALCAVELQKLRHDRSELYTRAVQPALWLLVFGETFTRIKAIPTHGIPYIDYLAPGIIAQSAMFIAIFYGIMIIWERDAGILTKLLVTPTPRAALITGKAFAAGVKALIQAVVVIVIAALLGVALTWNPLRLLGVAVAVVLGSAFFSCLSMTIAGIVLTRDRLMGIGQAITMPLFFASNALYPVSLMPGWLQAISRINPLSYQVDALRGLLLGTPAHLPLDYAVLAVAAALGIVAASSLLPRLAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JYZ8</accession>
    <name>A0A2M9JYZ8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">RNA polymerase subunit sigma-70</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CG723_08355</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CB01635</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN12086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN12086">
        <property type="protein sequence ID" value="PJN12086"/>
        <property type="gene ID" value="CG723_08355"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050896">
        <property type="term" value="P:response to stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039425">
        <property type="entry name" value="RNA_pol_sigma-70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013249">
        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43133">
        <property type="entry name" value="PTHR43133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08281">
        <property type="entry name" value="Sigma70_r4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="5">
        <location>
            <begin position="37"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4_2" evidence="6">
        <location>
            <begin position="134"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PJN12086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="193" mass="21400" checksum="D22046C959B7B590" modified="2018-04-25" version="1">MSFRHPASGTVDGLLTAPDDLLATRAGEGDEEAFAILMRRHSRLLLTLALHTLGNLQDAEDAVQDAFISAWRRLPEFRHACAFSTWMYRITVNRCLNSLRRRPAPVPLNAVAEPTAGADSSPAQAAEEDALASALADALGALEPRQRVCWILRELHGLPYEQIAQVTGTSQQTVRGRLYRARRSLKEMMGPWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-09-29" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JZG9</accession>
    <name>A0A2M9JZG9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CG723_04065</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CB01635</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000002">
        <property type="protein sequence ID" value="PJN12248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN12248">
        <property type="protein sequence ID" value="PJN12248"/>
        <property type="gene ID" value="CG723_04065"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004638">
        <property type="entry name" value="EmrB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00711">
        <property type="entry name" value="efflux_EmrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014987169" evidence="6">
        <location>
            <begin position="33"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="48"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="79"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="104"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="138"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="169"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="201"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="231"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="269"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="303"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="332"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="357"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="408"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="442"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="7">
        <location>
            <begin position="13"/>
            <end position="464"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PJN12248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="489" mass="51096" checksum="1D8277498BBD5F12" modified="2018-04-25" version="1">MPPPLTPRRRMLVLAICCMSLLIVSLDNTVLNVALPSMQKEFGASVSGMQWTIDAYTLVLASLLMLAGSTADRIGRRRIFKAGLVIFTVGSVLCSVAPNLESLIVFRMVQAVGGSMLNPVAMSIITNTFTEPRERARAIGVWGGVVGISMAAGPIVGGVLVDSVGWRSIFWINLPVGLAALLLTIRYVPESRAPKPRRTDPIGQLLVMVLLGSLTYAIIEAPEAGWTSPTIATFALLALVALIGLIAYEPRRAEPLIDLRFFRSAPFSGATVIAISAFASLGGFLFLSTLYLQNVRGLDALDAGLWMLPMAAMTLVCAPVSGRIVGSRGPRIPLLVAGIAMTASGLLFAAFEAETSNVTRFIGYVLFGLGFGFVNAPITNTAVSGMPRAQAGVAAAVASTSRQIGQTLGVAVIGAVLASGVAGAVGTSAYATTFVDASRGGWWIIVGCGLAVLLVGLLTSGRWARSTAQRTARCLEQPEIQEATAGASS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JZQ3</accession>
    <name>A0A2M9JZQ3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alkaline phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_04755</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000002">
        <property type="protein sequence ID" value="PJN12365.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN12365">
        <property type="protein sequence ID" value="PJN12365"/>
        <property type="gene ID" value="CG723_04755"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd07389">
        <property type="entry name" value="MPP_PhoD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018946">
        <property type="entry name" value="PhoD-like_MPP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038607">
        <property type="entry name" value="PhoD-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09423">
        <property type="entry name" value="PhoD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="SSF56300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PhoD" evidence="1">
        <location>
            <begin position="139"/>
            <end position="463"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF09423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN12365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="550" mass="60366" checksum="BDFFCF4A61C55016" modified="2018-04-25" version="1">MARLRLGPLLRYVDESSATVWVEASRPCTAEVRCTDGSSGRARTFQICGHHYALIPVTGLTPGSATAYEVLLDGVQVWPLADSPFPPSTIRTPAYDDAARPVRIAFGSCRWAAPPADGHDPVGPDALDTLATELAAAPEAERPDVLLLLGDQVYADETSPATRRYLAARRDLRDAPGNQVADYEEYTRLYYESWLDPDVRWLLSTVPSCMIFDDHDVIDDWNTSASWLAEIRATDWWNERILSGLMSYWVHQHLGNLAPPELAADPVYAAVRADPDGTDVLREFAARADADATSVRWSYRRDFGRVRLLMVDTRAARVLAESDRSMLDPTEAAWLREQSLESPGAYDHLLIGTSLPWLLPHLVHDAEGWNAALCRGERGARWARLGEKLRRRADLEHWAAFPASFDALTALIAEAGGGEGAPATVCVLSGDVHHAYVAEPAWPDGAPAPAARVLQLTCSPLHNSIPGSIKLGFRLGWSGFGRALGRRFARHGRLTTPPVSWRKTGGPWFGNQLMTLTLRGRAARLRLQEAQPVPGGKPGLREAADIVMSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-09-29" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K015</accession>
    <name>A0A2M9K015_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Peptidase M75</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CG723_05295</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CB01635</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the EfeM/EfeO family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000002">
        <property type="protein sequence ID" value="PJN12454.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN12454">
        <property type="protein sequence ID" value="PJN12454"/>
        <property type="gene ID" value="CG723_05295"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd14656">
        <property type="entry name" value="Imelysin-like_EfeO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1420.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028096">
        <property type="entry name" value="EfeO_Cupredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018976">
        <property type="entry name" value="Imelysin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034981">
        <property type="entry name" value="Imelysin-like_EfeO/Algp7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038352">
        <property type="entry name" value="Imelysin_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13473">
        <property type="entry name" value="Cupredoxin_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09375">
        <property type="entry name" value="Peptidase_M75"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014799575" evidence="3">
        <location>
            <begin position="31"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="domain" description="Cupredoxin_1" evidence="5">
        <location>
            <begin position="17"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M75" evidence="4">
        <location>
            <begin position="140"/>
            <end position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF09375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF13473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PJN12454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="385" mass="41891" checksum="A9678698810EE11B" modified="2018-04-25" version="1">MRAVRLTVVTAAATAATLAAVTGCTQKSDAKSGGDRVVEVTATDDKCDVSKTEFPAGHVELSIENKGSKVTEVYVLFPDDRIVSERENIGPGTKQKLTAEVKAGTYEIACKPGMKGDGIRQKVTVTGGKAVKRDARLDKAVAAYRTYAQEQADETLPKVTTFTDAVRKGDLKAAQAAYAPSRIGWERTEPVAESFGDIDPKVDVRADGLEEGQDPKTDWTGWHRLEKALWQDKKIGSREKELATQLDKDLKDWQTRVGKADITPTSMANGAKELLDEVATGKVTGEEERYSHTDLVDFKANVEGAEKAYDLLKPVAAENDAALTKELDKQFAALDTLLDKYRKDKTSYEFTSYDKVGKADRKELSDAVNALAEPLSKLAAAVVVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K0A4</accession>
    <name>A0A2M9K0A4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Carbohydrate kinase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CG723_05870</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CB01635</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the carbohydrate kinase PfkB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000002">
        <property type="protein sequence ID" value="PJN12559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN12559">
        <property type="protein sequence ID" value="PJN12559"/>
        <property type="gene ID" value="CG723_05870"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016773">
        <property type="term" value="F:phosphotransferase activity, alcohol group as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002173">
        <property type="entry name" value="Carboh/pur_kinase_PfkB_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011611">
        <property type="entry name" value="PfkB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002139">
        <property type="entry name" value="Ribo/fructo_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00294">
        <property type="entry name" value="PfkB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00990">
        <property type="entry name" value="RIBOKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="SSF53613"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00583">
        <property type="entry name" value="PFKB_KINASES_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PfkB" evidence="4">
        <location>
            <begin position="32"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PJN12559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="324" mass="35200" checksum="E0D956327D58E125" modified="2018-04-25" version="1">MRIAVTGSIATDHLMTFPGRFADQLVADQLHTVSLSFLVDNLDVRRGGVGANIAFGMGQLGTDPILVGAAGSDFDEYRAWLDRHGVDTASVRISEVLHTARFVCTTDVDHNQIGSFYTGAMSEARLIELQSVAERVGGLDLVLIGADDPEGMLRHTEECRSRSIPFAADFSQQIARMNGDEIRTLLDGATYLFSNEYEKGLIESKTGWTDEEILGKVGHRVTTLGSRGVRIEGVGEDPIEVGCAEEEAKVDPTGVGDAFRAGFLSGLAWGVGHERAAQVGCMLATLVIETLGTQEYQLRRGHFMDRFTKAYGHEAAAEVKEYLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K0E7</accession>
    <name>A0A2M9K0E7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_06120</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000002">
        <property type="protein sequence ID" value="PJN12605.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN12605">
        <property type="protein sequence ID" value="PJN12605"/>
        <property type="gene ID" value="CG723_06120"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041098">
        <property type="entry name" value="Rv2175c_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18367">
        <property type="entry name" value="Rv2175c_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rv2175c_C" evidence="1">
        <location>
            <begin position="65"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF18367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN12605.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="121" mass="13364" checksum="4103335E325DD7BA" modified="2018-04-25" version="1">MTEIDAKIDALVPEWLTLPDIAEQFGVEVTRVRQLVKEGQVIAVRRGENRALHVPAAFIDGDKVVKGLTGTLTLLRDDGYNDEEMLEWLFTPDPTLPGTPAQALSENRGTEVKRRAQALAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K0J6</accession>
    <name>A0A2M9K0J6_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Imidazole glycerol phosphate synthase subunit HisH</fullName>
            <ecNumber evidence="8">4.3.2.10</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">IGP synthase glutaminase subunit</fullName>
            <ecNumber evidence="8">3.5.1.2</ecNumber>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">IGP synthase subunit HisH</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">ImGP synthase subunit HisH</fullName>
            <shortName evidence="8">IGPS subunit HisH</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8 11" type="primary">hisH</name>
        <name evidence="11" type="ORF">CG723_06415</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CB01635</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>5-[(5-phospho-1-deoxy-D-ribulos-1-ylimino)methylamino]-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide + L-glutamine = 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide + D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate + H(+) + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:24793"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58278"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:58475"/>
            <dbReference type="ChEBI" id="CHEBI:58525"/>
            <dbReference type="EC" id="4.3.2.10"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 8">
            <text>H2O + L-glutamine = L-glutamate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:15889"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="EC" id="3.5.1.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 8">Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 5/9.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Heterodimer of HisH and HisF.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.3.2.10" evidence="8"/>
    <dbReference type="EC" id="3.5.1.2" evidence="8"/>
    <dbReference type="EMBL" id="NNBL01000002">
        <property type="protein sequence ID" value="PJN12655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN12655">
        <property type="protein sequence ID" value="PJN12655"/>
        <property type="gene ID" value="CG723_06415"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00031">
        <property type="reaction ID" value="UER00010"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004359">
        <property type="term" value="F:glutaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000107">
        <property type="term" value="F:imidazoleglycerol-phosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01748">
        <property type="entry name" value="GATase1_IGP_Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00278">
        <property type="entry name" value="HisH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017926">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010139">
        <property type="entry name" value="Imidazole-glycPsynth_HisH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42701">
        <property type="entry name" value="PTHR42701"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00117">
        <property type="entry name" value="GATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000495">
        <property type="entry name" value="Amidotransf_hisH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01855">
        <property type="entry name" value="IMP_synth_hisH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="6 8" id="KW-0368">Histidine biosynthesis</keyword>
    <keyword evidence="5 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 8" id="KW-0456">Lyase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GATase" evidence="10">
        <location>
            <begin position="16"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="8 9">
        <location>
            <position position="91"/>
        </location>
    </feature>
    <feature type="active site" evidence="8 9">
        <location>
            <position position="201"/>
        </location>
    </feature>
    <feature type="active site" evidence="8 9">
        <location>
            <position position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000495-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PJN12655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="220" mass="23790" checksum="86FA64C5410D5A33" modified="2018-04-25" version="1">MTSAKPAGTAGKKVVVFDYGFGNVRSAERALARAGADVEITRDFDTALNADGLLVPGVGAFAACMKGLKEARGDWIIDRRLAGGRPVMGICVGMQILFARGIEHGVEAEGLDEWPGTVEPLKAEIVPHMGWNTVRPPQDTELFAGLDSDARFYFVHSYAVQQWDFEVGNVHMRPPKVTWATHGEPFIAAVENGALWATQFHPEKSGDAGAQLLTNWIGTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-09-29" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K0R4</accession>
    <name>A0A2M9K0R4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CG723_06440</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CB01635</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000002">
        <property type="protein sequence ID" value="PJN12660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN12660">
        <property type="protein sequence ID" value="PJN12660"/>
        <property type="gene ID" value="CG723_06440"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="23"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="55"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="87"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="113"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="156"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="181"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="231"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="270"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="295"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="322"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="356"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="387"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="1"/>
            <end position="410"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PJN12660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="415" mass="40957" checksum="24FE993E35D8E6AE" modified="2018-04-25" version="1">MTVTAPLAGTPAPGKPAHRDGNVLRWLGAYASSMIGDNIYYVALSWAAVQSGSPSQAGLVMAVSAAPRALLMLGGGVIADRLGPRRIVIAGDAVRSAAVLGVAGLFLATRPGLWPLTFLGLVFGIVDALFLPAVGALPARVTGRDQLARVQGMRGLAVRLANVVGAPLGGLGVALGGLAAAFGAAGLLFAISLPLLMSLRIRDLPDAGGKSGAPARNGLVDGLRYIRRHSVLAPLVVVIGLSDLGFVGPLNVGLTLLADQRGWGASGMGSVLAGFGVGAGAASLLLAVRGRVPRAGLVLAATMGGGAVAIGALAFVPHLAAAVAVALAIGLLAGLSGALCGALTQTHADPACIGRVTAVTSLSSLGLVPLTMPLTGAAVGLWGTGPVFVASAAICALAGVYGLCRAPLRRAELPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K0S5</accession>
    <name>A0A2M9K0S5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">SAM-dependent methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CG723_06940</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000002">
        <property type="protein sequence ID" value="PJN12741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN12741">
        <property type="protein sequence ID" value="PJN12741"/>
        <property type="gene ID" value="CG723_06940"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PJN12741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="225" mass="24068" checksum="4A17A2939788DA4C" modified="2018-04-25" version="1">MREGYGGTGPGAITPDGCAVDLYARLPVGDEPDIIAAAVPAGASILELGSGVGRMTHPLVERGFTVTAVDESAEMLERVRGARTICSPVESLDAGGTFDVVLLASFLVHAGDVAVRQGLLDTCRRHVADRGCVLIQREGPDYHTNLPRERVDPSGFTVRIVSADPVGDGVNSVRAEYEFPDAAWTHTFLARPLTQEQFEEALAQAGLKVDRYLTDDQVWVRAVPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K133</accession>
    <name>A0A2M9K133_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Proteasome protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CG723_06910</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000002">
        <property type="protein sequence ID" value="PJN12737.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN12737">
        <property type="protein sequence ID" value="PJN12737"/>
        <property type="gene ID" value="CG723_06910"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000502">
        <property type="term" value="C:proteasome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10900">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008492">
        <property type="entry name" value="DUF774"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019151">
        <property type="entry name" value="Proteasome_assmbl_chaperone_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038389">
        <property type="entry name" value="PSMG2_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09754">
        <property type="entry name" value="PAC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028754">
        <property type="entry name" value="UCP028754"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0647">Proteasome</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PJN12737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="312" mass="34312" checksum="721E45C55BBA1880" modified="2018-04-25" version="1">MLDPQGLYAWEPKGLAVVDMALAQESAGLVMLYHFDGYIDAGETGEQIVDRVLDSLPHQVVARFDHDRLVDYRARRPLLTFRRDRWTDYDVPALEVRLVQDATGAPFLLLSGPEPDVEWERFAAAVKEIVERLGVRLAVNFHGIPMGVPHTRPVGLTPHGNRTELVPGHRSPFDEAQVPGSAESLVEYRLMEAGHDVLGVAAHVPHYIARSPYPDAALTVLEAITAATGLVLPSVAHGLRTEAHRTQTEIDRQIQEGDEELVSLVQGLEHQYDAAAGAESRGNMLAEPTDIPSADEIGLEFEKFLAEREGDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K1K6</accession>
    <name>A0A2M9K1K6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_06470</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000002">
        <property type="protein sequence ID" value="PJN13005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN13005">
        <property type="protein sequence ID" value="PJN13005"/>
        <property type="gene ID" value="CG723_06470"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021215">
        <property type="entry name" value="DUF2752"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10825">
        <property type="entry name" value="DUF2752"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="81"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="115"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN13005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="140" mass="14339" checksum="F59F9EB9DCA6B88A" modified="2018-04-25" version="1">MTSGAGSAGASLRRLAVPLGVLAPIGAGFAYVGSVDPNEPGHYPACPLLHYTGIYCPGCGGLRSAHALVHGDLTAALGDNALAVAGCAVFAVLWVVWAVRVVLGRPVRIDLGRPQLWAVGAVVLVFTVVRNLPLGGWLHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K1M7</accession>
    <name>A0A2M9K1M7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_00060</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000001">
        <property type="protein sequence ID" value="PJN13042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN13042">
        <property type="protein sequence ID" value="PJN13042"/>
        <property type="gene ID" value="CG723_00060"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="12"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN13042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="124" mass="13389" checksum="9C97F8DA78A6ACE0" modified="2018-04-25" version="1">MILLRRLLGDVLRRQRQRQGRTLREVSSSARVSLGYLSEVERGQKEASSELLSAICDALDVRMSELMREVSDELALAELAESAAATDPVPAPVRPRLNSVSVAGVPPERVTIKAPAEAVDVVAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K1R6</accession>
    <name>A0A2M9K1R6_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">tRNA dimethylallyltransferase</fullName>
            <ecNumber evidence="5">2.5.1.75</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Dimethylallyl diphosphate:tRNA dimethylallyltransferase</fullName>
            <shortName evidence="5">DMAPP:tRNA dimethylallyltransferase</shortName>
            <shortName evidence="5">DMATase</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">Isopentenyl-diphosphate:tRNA isopentenyltransferase</fullName>
            <shortName evidence="5">IPP transferase</shortName>
            <shortName evidence="5">IPPT</shortName>
            <shortName evidence="5">IPTase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">miaA</name>
        <name evidence="9" type="ORF">CG723_00235</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CB01635</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 5 7">Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 5 6">
            <text>adenosine(37) in tRNA + dimethylallyl diphosphate = diphosphate + N(6)-dimethylallyladenosine(37) in tRNA</text>
            <dbReference type="Rhea" id="RHEA:26482"/>
            <dbReference type="Rhea" id="RHEA-COMP:10162"/>
            <dbReference type="Rhea" id="RHEA-COMP:10375"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57623"/>
            <dbReference type="ChEBI" id="CHEBI:74411"/>
            <dbReference type="ChEBI" id="CHEBI:74415"/>
            <dbReference type="EC" id="2.5.1.75"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="5">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 5 8">Belongs to the IPP transferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.75" evidence="5"/>
    <dbReference type="EMBL" id="NNBL01000001">
        <property type="protein sequence ID" value="PJN13071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN13071">
        <property type="protein sequence ID" value="PJN13071"/>
        <property type="gene ID" value="CG723_00235"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052381">
        <property type="term" value="F:tRNA dimethylallyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00185">
        <property type="entry name" value="IPP_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039657">
        <property type="entry name" value="Dimethylallyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018022">
        <property type="entry name" value="IPT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11088">
        <property type="entry name" value="PTHR11088"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00174">
        <property type="entry name" value="miaA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5 8" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 6" id="KW-0819">tRNA processing</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="5">
        <location>
            <begin position="17"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Interaction with substrate tRNA" evidence="5">
        <location>
            <begin position="40"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="15"/>
            <end position="22"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="site" description="Interaction with substrate tRNA" evidence="5">
        <location>
            <position position="106"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with substrate tRNA" evidence="5">
        <location>
            <position position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001549"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003784"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003785"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PJN13071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="312" mass="33905" checksum="8AC9DDC5E6D214D4" modified="2018-04-25" version="1">MSSAAPAPRVIAVVGPTAAGKSDLGVFLARELGGEVVNADSMQLYRGMDIGTAKLTPEERDGVPHHLLDIWDVTEAASVAEYQKLARAEIDRLLAAGRWPVLVGGSGLYVRGAVDHLEFPGTDPEVRARLEEELTLRGSGALHARLAVCDPGAAKAILPSNGRRIVRALEVIEITGKPFTANLPGHESVYDTVQIGVDVARPELDERIATRVDRMWDAGLVDEVRTLEERGLREGRTASRALGYQQVLAALAGECTEGEARAETVRATKRFARRQDSWFRRDPRVHWLSGEAAERGELPARAMTLIERPVTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K276</accession>
    <name>A0A2M9K276_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Lant_dehydr_C domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_00885</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000001">
        <property type="protein sequence ID" value="PJN13180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN13180">
        <property type="protein sequence ID" value="PJN13180"/>
        <property type="gene ID" value="CG723_00885"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023809">
        <property type="entry name" value="Thiopep_bacteriocin_synth_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14028">
        <property type="entry name" value="Lant_dehydr_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03891">
        <property type="entry name" value="thiopep_ocin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lant_dehydr_C" evidence="1">
        <location>
            <begin position="6"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN13180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="296" mass="32230" checksum="147AE1660E0A2883" modified="2018-04-25" version="1">MTWSSWHLHLATTARSAHDRVLADVIGPTIGELAPGTPWFFIRYWQAGPHLRLRIGDLDPDTYDHVEEVLRVRLAEAGALRPGEEPLDPDAYLEGAGALASAGEQGDDRHVRAMLAPGVHRADYDPEFDRYGGPALMSVTEDLFRLSSELVLRLAPKASSQQQRALLALRGTMAAAAALGDTAERGYFYAHGLGAWRAWAGEAGYPDELLDSLTTITRDAGAKPVDPLAHGPFAYWHDGLAALTGDIRAKSPTHPGMILFSHAHMLHNRLGLSLLEELRNYAWLAHVFPVAEGALA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-09-29" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K301</accession>
    <name>A0A2M9K301_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">3-hydroxybutyryl-CoA dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_02755</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000001">
        <property type="protein sequence ID" value="PJN13502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN13502">
        <property type="protein sequence ID" value="PJN13502"/>
        <property type="gene ID" value="CG723_02755"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070403">
        <property type="term" value="F:NAD+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006176">
        <property type="entry name" value="3-OHacyl-CoA_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006108">
        <property type="entry name" value="3HC_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00725">
        <property type="entry name" value="3HCDH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02737">
        <property type="entry name" value="3HCDH_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="SSF48179"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="3HCDH_N" evidence="2">
        <location>
            <begin position="15"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="domain" description="3HCDH" evidence="1">
        <location>
            <begin position="196"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="domain" description="3HCDH_N" evidence="2">
        <location>
            <begin position="322"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="domain" description="3HCDH" evidence="1">
        <location>
            <begin position="502"/>
            <end position="598"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN13502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="601" mass="63674" checksum="E8000E155C656DEF" modified="2018-04-25" version="1">MDAPLSPASPATLPTVAVVGLGTMGTGIAEVLARAGREVIGIDISEAAGAQAVAALEASTARAVRRERLTEDERRDVLARFRTFTDLQAAADADLVIEVAPESYDIKQQIFRDLDAVVRPETILATGTNALSVTRLAADSARPERVLGLHFFNPAPAMKLVEVVSSVLTAPTAVAAVTDLAVELGKEPVAVGDRPGFVADGLLFGYLNQAAAMYEAKYASREDIDAAMKLGCGLPMGPLALLDLIGIDTARRVLDAMYTESHDRLHAPAPVLKQLSEAGLTGRKSGRGFYTYAEPGSSEVVRDALTPLAGEVVDGARTIRSVGVAGSGTMASGIAEVFAKAGYDVVLAARSEEKAEKAKSRIGKSLSRSVDKGRMTAEAAAQTLDRITPAGSYDAFSDVDLALEAVAEDLEIKQQLFGTFDKVCKPGAVLATTTSSLPVVACARATSRPQDVIGMHFFNPAPAMKLVEVVRTVLTGDDVHATVREVCTKIRKHPVDCGDRAGFIVNALLFPYLNNAIKMVQEHYATLDDIDAAMRLGGGYPMGPFELLDVVGLDVSLAIEKVLHREFRDPGLAPAPLLEHLVAAGCLGRKTGRGFREYARR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K371</accession>
    <name>A0A2M9K371_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Tat (Twin-arginine translocation) pathway signal sequence</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_03160</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000001">
        <property type="protein sequence ID" value="PJN13574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN13574">
        <property type="protein sequence ID" value="PJN13574"/>
        <property type="gene ID" value="CG723_03160"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019546">
        <property type="entry name" value="TAT_signal_bac_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036237">
        <property type="entry name" value="Xyl_isomerase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013022">
        <property type="entry name" value="Xyl_isomerase-like_TIM-brl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01261">
        <property type="entry name" value="AP_endonuc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51658">
        <property type="entry name" value="SSF51658"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01409">
        <property type="entry name" value="TAT_signal_seq"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014760784" evidence="1">
        <location>
            <begin position="50"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="domain" description="AP_endonuc_2" evidence="2">
        <location>
            <begin position="98"/>
            <end position="371"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN13574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="386" mass="42008" checksum="C312B03E0381A3B9" modified="2018-04-25" version="1">MTAFNDESGPGDALRRALGVSRRRFLSTCTAAGAAAVAAPVFGASPALAQSTHNGGRGGGHHALVPASKRGIILYTVRDATGRDPLASNLPSGFREVFKELARYGYKQVEFAGYGQHANAPGGANLESVEGAKLLRSWLDEYGLRAQGNHGFIPGSWPLSQPDLDTFKKHLEIANILGMDHMGTGGDPTGSAYRSDWDTAADKWNALGKIAHGAGLKLYTHNHDAAYGFLLDGGPLDAQGKPTRSSGIRKLEYFLKVTDPKTVWLEMDIFWAHVAQYKFHTYTAHDGSQRENVFDPAALVSRNNKRYPLFHAKDGTVNETNGMGYDMVPFGTGVIDYERFFTRVGAMNYHNPMVEQDNAPSDTDLGQSLKFAKIGYDNLAGLRKKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K3F7</accession>
    <name>A0A2M9K3F7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CG723_03650</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000001">
        <property type="protein sequence ID" value="PJN13652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN13652">
        <property type="protein sequence ID" value="PJN13652"/>
        <property type="gene ID" value="CG723_03650"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PJN13652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="341" mass="36653" checksum="CDA2482C48A3FFE8" modified="2018-04-25" version="1">MSAEYATFGLAPAMRAGGVLTNGDYQVHREFLDFIVNGSPLLFQLSDLDAVSPLASDIPPAIFTAHVRSLLLEADAPLPDGRYVIYGCPECEGLECGAVTAVIEADGPDVIWRDFAWQTEERADLELNGYHGIGPFRFHGAAYRESLRPLLDGGAEPAPARRVLLIGARVAVLARLAAALRTIGIGAEITQDAAGVPPDELRTYGAVAFGRAVSESDRAAVREQFERAGAETAYVDGLAPIIPLLVAQIESALDRRAVPQRRLTRLVAADGEAGLEVTSACRVRLTAYRLDRLYRSHAQDVFDAVLEPGRHRIALDPKATRGESFVVARTTGSVLVAPMAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JEM5</accession>
    <name>A0A2M9JEM5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Class II aldolase/adducin family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_45420</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000054">
        <property type="protein sequence ID" value="PJN05329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN05329">
        <property type="protein sequence ID" value="PJN05329"/>
        <property type="gene ID" value="CG723_45420"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.225.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001303">
        <property type="entry name" value="Aldolase_II/adducin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036409">
        <property type="entry name" value="Aldolase_II/adducin_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00596">
        <property type="entry name" value="Aldolase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01007">
        <property type="entry name" value="Aldolase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53639">
        <property type="entry name" value="SSF53639"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldolase_II" evidence="1">
        <location>
            <begin position="39"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM01007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN05329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="268" mass="29383" checksum="EEEE85C5A09F7112" modified="2018-04-25" version="1">METLTADTQAALGTEDQIAALNLRPAGLSVEDERQLRKQELAASFRLFGKLGFGEGVAGHITARDPGDPDCFWVNPFSMSFRHIRASDLLLVDSAGNVVEGSRPVNRAAFCIHSEVHRARPDVVAAAHAHSTYGKAFSSLGVRLDPLTQDACAFYEDHGLYADYQGVVNDTEEGRRIGQALGPHKAVILQNHGNLTVGQTVPEAAWWFITMERSCQAQLLAMAAGTPKHIDHDSAVVVREQTGTPLSGWFQLRPLWDEIVREEPDLFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JEQ1</accession>
    <name>A0A2M9JEQ1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CG723_45330</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CB01635</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">In the C-terminal section; belongs to the transposase 35 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000052">
        <property type="protein sequence ID" value="PJN05358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN05358">
        <property type="protein sequence ID" value="PJN05358"/>
        <property type="gene ID" value="CG723_45330"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032196">
        <property type="term" value="P:transposition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001959">
        <property type="entry name" value="Transposase_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010095">
        <property type="entry name" value="Transposase_IS605_OrfB_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01385">
        <property type="entry name" value="OrfB_IS605"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07282">
        <property type="entry name" value="OrfB_Zn_ribbon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01766">
        <property type="entry name" value="tspaseT_teng_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0815">Transposition</keyword>
    <feature type="domain" description="OrfB_IS605" evidence="6">
        <location>
            <begin position="163"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="domain" description="OrfB_Zn_ribbon" evidence="7">
        <location>
            <begin position="311"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="385"/>
            <end position="404"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF07282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PJN05358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="424" mass="47695" checksum="0EF160C57450AB50" modified="2018-04-25" version="1">MTARGFLRAQQVHLTPTTARRAGACGRKASGYQWRSRRISSRPPLALSVRFCVRFHGSLHPWWRGVNAIVCQQAFRDADTAFSSWKSAARRGVQVGYPRPKWYGRCRDSFRMFSVRLHRPARRLARLLARGGEVKSVTIAREGRAWFASFTVRIPAAEPVRASRRQRSAGTVGVDLGVTVFAATSSPLVIGDDKVQLFENPRHLDNARRLLHKWQRRMARRHVKGLPARRQSAGRRQARDEVARLHALVAARRASTQHLLTKRLVTQFAHVALEDLQVKNMTRSARGTVQEPGRNVMAKAGLNRSMLDVGFAEIRRQIEYKAPWYGARVSAVNPAYTSQTCSQCGHVDAKSRRTRDLFTCTRCGHHTHADIGAALNIKHRALTAQEELPDEPDRGQRPGTDRKRVEGWVTVLPAALICPIPASR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JF56</accession>
    <name>A0A2M9JF56_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_44275</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000046">
        <property type="protein sequence ID" value="PJN05535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN05535">
        <property type="protein sequence ID" value="PJN05535"/>
        <property type="gene ID" value="CG723_44275"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="35"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN05535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="67" mass="7398" checksum="E59BC2D0C5B368D7" modified="2018-04-25" version="1">MNRAVEVREHHVEIPGICFIRQPEGALRCTLSAGHGGENKHSYSGPLRNGFRVGTTWPRRSGEAQAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-06-02" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JF73</accession>
    <name>A0A2M9JF73_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_44715</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000048">
        <property type="protein sequence ID" value="PJN05453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN05453">
        <property type="protein sequence ID" value="PJN05453"/>
        <property type="gene ID" value="CG723_44715"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="30"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN05453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="62" mass="6517" checksum="163BEFE95D9AE194" modified="2018-04-25" version="1">MPTAQRPEGDETDDGSGAGLSLVLESGEKNPIQAPTTSSPTTTTPVPDFFARVPLPSDRFTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JFD7</accession>
    <name>A0A2M9JFD7_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DDE Tnp4 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CG723_44550</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CB01635</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000048">
        <property type="protein sequence ID" value="PJN05467.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN05467">
        <property type="protein sequence ID" value="PJN05467"/>
        <property type="gene ID" value="CG723_44550"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027806">
        <property type="entry name" value="HARBI1_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13359">
        <property type="entry name" value="DDE_Tnp_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDE Tnp4" evidence="4">
        <location>
            <begin position="15"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PJN05467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="84" mass="9668" checksum="6542398A31399471" modified="2018-04-25" version="1">MLWTSTARPARGSEITCCKKPKGKKLPPAKKQVNQLIGAERAVCEHAFAHLKNWRVLTRLRLNVKRATRLVRALMVLNWHEIAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JFP5</accession>
    <name>A0A2M9JFP5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Conjugal transfer protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_43355</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000043">
        <property type="protein sequence ID" value="PJN05652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN05652">
        <property type="protein sequence ID" value="PJN05652"/>
        <property type="gene ID" value="CG723_43355"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="48"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="79"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="105"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="285"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN05652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="369" mass="38781" checksum="EB1A45BE3E690E16" modified="2018-04-25" version="1">MTAQARKPLTKVQIIVLSAAFVPMLATGVFGGIGTYSNISGAYGKGTALGAVSAGEGATAVLALVLLGLTMLGQSSPRIIRLGLWALPAAASAMAAMAADDRGTTVIYAITPMGMCVSAEGMAFLARRIAVHTDGRDAEGERRAVEVVQRLAYHRARATNHPDAKMRKRSDRVSWRLARKVGSGDAVLGSALLDVQRQRVTIGADAALGAMFRLAPDALPPVGANMEESAETVRIRSTADLPESTPAPITAKPIVLPSPVAVGFLKSTLPSKPVRAIESAPVRPIEKRTVPAESTRPRGATGRVPDAARSSRPKRTAAELLDEARTETEDWPDAKLTAEGIRLAVHTSPKNARLLRDTLRAERAGEAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-05-25" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JFT3</accession>
    <name>A0A2M9JFT3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Aldo/keto reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_43690</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000044">
        <property type="protein sequence ID" value="PJN05607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN05607">
        <property type="protein sequence ID" value="PJN05607"/>
        <property type="gene ID" value="CG723_43690"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NADP_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="SSF51430"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldo_ket_red" evidence="2">
        <location>
            <begin position="13"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="305"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN05607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="325" mass="35092" checksum="40B55C8236A76AE8" modified="2018-04-25" version="1">MRYINLRDLEVSRIGLGAMGMSHGYTGSGTDDAESIRAVRRALELGVTLIDTAEIYGPYINEDLLGKALKGRRDQVVLATKFGLVSHGGEGAWNLDSGPANIRTAVEGSLKRLGTDHIDLYYQHRVDPNTPIEETAGAVGELIAAGKVRAFGLSEAGPDTIRRAHAVQPVTAVQSEYSLWTRGIEERVLPVLRELNIGLVPFSPLGRGFLTGTVRSTDQFDEDDFRRDNPRFTGENFRRNLALADEVKALAAEVGATPAQVALAWLLAQGDDIAPIPGTKRVSRVEENTAADAVTLTAEQLDQLSSLPPAAGDTHTEAQAQMLER</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JG04</accession>
    <name>A0A2M9JG04_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_42540</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000040">
        <property type="protein sequence ID" value="PJN05820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN05820">
        <property type="protein sequence ID" value="PJN05820"/>
        <property type="gene ID" value="CG723_42540"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021426">
        <property type="entry name" value="DUF3073"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11273">
        <property type="entry name" value="DUF3073"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="45"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN05820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="85" mass="9298" checksum="68BEAF6B2E08C969" modified="2018-04-25" version="1">MGRGRAKAKQTKVARQLKYSSGGTDLSRLANELGASTSNQPPNGEPFEDDDEEDDPYAQYADLYNDDEDDEDSDESGPSPQRRGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JG67</accession>
    <name>A0A2M9JG67_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_42350</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000039">
        <property type="protein sequence ID" value="PJN05879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN05879">
        <property type="protein sequence ID" value="PJN05879"/>
        <property type="gene ID" value="CG723_42350"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_2-like" evidence="1">
        <location>
            <begin position="19"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN05879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="540" mass="59296" checksum="C19B7F08E1CD56AE" modified="2018-04-25" version="1">MEAVQPEPQQPSPPQSQVSVVVIGYNDAARVPDAVRSALSQGPAVREVIAVDDCSTDGSGELLRRTADDEPRLKVVRRAANSGGCGTPRNDGIDTASAPYVMFLDSDDVLPPGAVDALLGAALAHGTEVAAGLCVRRELPSGRDIPWQPELYAEPAVVPHPERRPRLVHDTLCVNKLYRTDFLREHGIRFPDGRFVYEDFVFTARVLAAGPRIALVPDTVYIWNVRRDADRLSLSLDRAGLDNWTGRIEAHRQSVDILLTASHKRLARAARTRFLDHSLRMYARELDLRSPGYRAEWWDSTRAYLATFDTADIDAAPAPGRVVARVILASDHPRDLPRLKEVAARPARLRPPYARAADGTPIWSDDLPQVTLEHLLVRPMGLLPIAIEAELRPRARGSRLRLRLHDLYGRVAEAGPATVDIEVIDRRRHRPARRRTVTLVPGRDAGTWEAETSLDLSALASGTWDLRLHVNFADGTSRDAGAHAVTGPGLLRRTALPSLRHGMLLAHPYATHSGALAVRLAPGVRGALAVARGRLNRLVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JGI0</accession>
    <name>A0A2M9JGI0_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Methylthioribose-1-phosphate isomerase</fullName>
            <shortName evidence="2">M1Pi</shortName>
            <shortName evidence="2">MTR-1-P isomerase</shortName>
            <ecNumber evidence="2">5.3.1.23</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">S-methyl-5-thioribose-1-phosphate isomerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2 3" type="primary">mtnA</name>
        <name evidence="3" type="ORF">CG723_42215</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>S-methyl-5-thio-alpha-D-ribose 1-phosphate = S-methyl-5-thio-D-ribulose 1-phosphate</text>
            <dbReference type="Rhea" id="RHEA:19989"/>
            <dbReference type="ChEBI" id="CHEBI:58533"/>
            <dbReference type="ChEBI" id="CHEBI:58548"/>
            <dbReference type="EC" id="5.3.1.23"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-methionine biosynthesis via salvage pathway; L-methionine from S-methyl-5-thio-alpha-D-ribose 1-phosphate: step 1/6.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the EIF-2B alpha/beta/delta subunits family. MtnA subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.23" evidence="2"/>
    <dbReference type="EMBL" id="NNBL01000039">
        <property type="protein sequence ID" value="PJN05857.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN05857">
        <property type="protein sequence ID" value="PJN05857"/>
        <property type="gene ID" value="CG723_42215"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00904">
        <property type="reaction ID" value="UER00874"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046523">
        <property type="term" value="F:S-methyl-5-thioribose-1-phosphate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019509">
        <property type="term" value="P:L-methionine salvage from methylthioadenosine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019284">
        <property type="term" value="P:L-methionine salvage from S-adenosylmethionine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10470">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01678">
        <property type="entry name" value="Salvage_MtnA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000649">
        <property type="entry name" value="IF-2B-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005251">
        <property type="entry name" value="IF-M1Pi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042529">
        <property type="entry name" value="IF_2B-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011559">
        <property type="entry name" value="Initiation_fac_2B_a/b/d"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027363">
        <property type="entry name" value="M1Pi_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01008">
        <property type="entry name" value="IF-2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="SSF100950"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00524">
        <property type="entry name" value="eIF-2B_rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00512">
        <property type="entry name" value="salvage_mtnA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="1 2 3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="2" id="KW-0486">Methionine biosynthesis</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="2">
        <location>
            <begin position="64"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="2">
        <location>
            <begin position="263"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="2">
        <location>
            <position position="253"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="98"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="212"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="2">
        <location>
            <position position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN05857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="382" mass="39596" checksum="2AA62B59EF6A6FD1" modified="2018-04-25" version="1">MADQYAQTGDDKRPTDIPVLRWEEPAEGPALVLLDQTRLPVEEVELVCTDAQGLVQAIRTLAVRGAPVLGIAGAYGVALAAARGFDVDEAAVALAGARPTAVNLAKGVRRAHAAYRAGLGAEGDRERAARDALAAARALHREDAEASAAMARHGLALLDEMMPGGQHRILTHCNTGALVSGGEGTAFAVALAAHRVGRLTRLWVDETRPLLQGSRLTAYEAARAGMAYTLLTDNAAGSLFAAGEVDAVLVGADRIVADGSVANKVGTYPLAVLAKYHHVPFIVVAPATTVDPETPDGASVEVEQRAGHEVTEVTAPQVPMAGVEAGGVFPVAPLGTQAYNPAFDVTPPELVTAIVTEWGVVSPVTAEGLGELCARSRQVTIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JGX4</accession>
    <name>A0A2M9JGX4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Arginine-ornithine antiporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CG723_41930</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CB01635</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the amino acid-polyamine-organocation (APC) superfamily. Basic amino acid/polyamine antiporter (APA) (TC 2.A.3.2) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000037">
        <property type="protein sequence ID" value="PJN06007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN06007">
        <property type="protein sequence ID" value="PJN06007"/>
        <property type="gene ID" value="CG723_41930"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006865">
        <property type="term" value="P:amino acid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004754">
        <property type="entry name" value="Amino_acid_antiprt"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00905">
        <property type="entry name" value="2A0302"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="52"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="89"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="116"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="139"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="169"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="213"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="244"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="294"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="342"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="368"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="409"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="432"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="462"/>
            <end position="484"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PJN06007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="486" mass="51343" checksum="562C38615A7C4A75" modified="2018-04-25" version="1">MTQAEGTLSADQPEQSPTAKLTLLTLTTMVVGSMVGAGVFSLPSRFAQETGVAGALIAWAIAGTGMLMLAFVFQTLAVRRPDLDAGVYAYAKAGFGEYLGFFSAFGYWASACVGNVTYWVLIMSTIGAIAPALGDGDTALAIILSSAGLWAFFFLIRRGVKEAATINRVVTVAKVVPILVFVVLALFCLKPHVFAENFGGADYAGSLFSQVRGTMLATVFVFLGVEGASVYSRHAKRREDVGRATVLGFLSVFAVFASVTIVSYGILPMSEIAELRQPSMAGVLEEAVGTWGKVFVSVGLIISVLGAYLAWTLMSAEVLLVAARDKDMPRFLARTNHADVPVPALVMTTALSQVVLVITSFSDDAFNFALDLTSALSLIPFLLAAAFAVKIALRPDELTVGARDSRGELVVAVIATVYTAFLLYAAGVKFVLVSLIIYAPATVLFVMARREQGRRLFSPTELVILAVSVAGAVLGVIALAAGWISL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JH60</accession>
    <name>A0A2M9JH60_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Type I-E CRISPR-associated protein Cas6/Cse3/CasE</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">cas6e</name>
        <name evidence="2" type="ORF">CG723_40835</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000035">
        <property type="protein sequence ID" value="PJN06097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN06097">
        <property type="protein sequence ID" value="PJN06097"/>
        <property type="gene ID" value="CG723_40835"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010179">
        <property type="entry name" value="CRISPR-assoc_prot_Cse3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08798">
        <property type="entry name" value="CRISPR_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01101">
        <property type="entry name" value="CRISPR_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01907">
        <property type="entry name" value="casE_Cse3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="108"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="160"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN06097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="224" mass="24958" checksum="DCB8819032FDFAA5" modified="2018-04-25" version="1">MPQASLTRIHLNLTHPTVRRDLADYPRLHKTLMSLADDHLGPHPRQQAGLLFRLETDQRVPTLYVQTRQTPLTQRLPTGYGTAETRDLTPLLTHLQTGRHIRYRITASPTARIGNNPPPRHRDPRPGHRPTTLPRGAITPLHGPDALQWWHRRARQAGLTLTTTTHTPRPFRRPRGAQPGPHHHLVQFDGTAHISDPHALATALTDGIGRGRAYGAGLLSLAPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JHB1</accession>
    <name>A0A2M9JHB1_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Apolipoprotein N-acyltransferase</fullName>
            <shortName evidence="8">ALP N-acyltransferase</shortName>
            <ecNumber evidence="8">2.3.1.269</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8 11" type="primary">lnt</name>
        <name evidence="11" type="ORF">CG723_40330</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CB01635</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the phospholipid dependent N-acylation of the N-terminal cysteine of apolipoprotein, the last step in lipoprotein maturation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>a glycerophospholipid + N-terminal S-1,2-diacyl-sn-glyceryl-L-cysteinyl-[lipoprotein] = a 2-acyl-sn-glycero-3-phospholipid + H(+) + N-acyl-S-1,2-diacyl-sn-glyceryl-L-cysteinyl-[lipoprotein]</text>
            <dbReference type="Rhea" id="RHEA:48228"/>
            <dbReference type="Rhea" id="RHEA-COMP:14681"/>
            <dbReference type="Rhea" id="RHEA-COMP:14684"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:136912"/>
            <dbReference type="ChEBI" id="CHEBI:140656"/>
            <dbReference type="ChEBI" id="CHEBI:140657"/>
            <dbReference type="ChEBI" id="CHEBI:140660"/>
            <dbReference type="EC" id="2.3.1.269"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="8">Protein modification; lipoprotein biosynthesis (N-acyl transfer).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the CN hydrolase family. Apolipoprotein N-acyltransferase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.269" evidence="8"/>
    <dbReference type="EMBL" id="NNBL01000033">
        <property type="protein sequence ID" value="PJN06266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN06266">
        <property type="protein sequence ID" value="PJN06266"/>
        <property type="gene ID" value="CG723_40330"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00666"/>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016410">
        <property type="term" value="F:N-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042158">
        <property type="term" value="P:lipoprotein biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07571">
        <property type="entry name" value="ALP_N-acyl_transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01148">
        <property type="entry name" value="Lnt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004563">
        <property type="entry name" value="Apolipo_AcylTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003010">
        <property type="entry name" value="C-N_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036526">
        <property type="entry name" value="C-N_Hydrolase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045378">
        <property type="entry name" value="LNT_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00795">
        <property type="entry name" value="CN_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20154">
        <property type="entry name" value="LNT_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56317">
        <property type="entry name" value="SSF56317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00546">
        <property type="entry name" value="lnt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50263">
        <property type="entry name" value="CN_HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8 11" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="2 8" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="11" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8 11" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="31"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="54"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="77"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="167"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="208"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="501"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="domain" description="CN hydrolase" evidence="10">
        <location>
            <begin position="239"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PJN06266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="532" mass="56461" checksum="1E77E8AC05EBDFA6" modified="2018-04-25" version="1">MTATATSVDEPEQLDPQSAPASRWARLPRRIAPAAAAVLSGVLLYAGFPPRELWWLAPLALGLFGASVYGRRLRAGFGLGFLMGLAFLVPLLSWTGVDVGPLPWLALALAESLVMALAGLGIAYVSRLPLWPLWAAGVWIADEALRARFPFGGFPWGKVAFGQPSGLFLPLASLGGTPLLGFAVVLCGFGLTALALRLKDVRGVRDRGVAVAAAFTVAPVIAGAVAAPLVSTAAEEGTARVAVIQGNVPRMGLDFNSQRRAVLDYHVRETMKLATKIKAGQVKKPDLVLWPENSSDIDPYVNPDAYAEIDKAARAVGAPISVGAVVTAKDGTPRNRQILWDPKTGPGAVYDKRQLQPFGEYMPYRSFFRIFSKDVDRAGNFVAGEKPVVFDMAGTKIGPVTCYEAAFDSVVRDQVKAGAQILSVPSNNATFDRSQMTYQQLAMDRVRAVEHGRAVMVPVTSGVSAVIRPDGSVAQHTGMFVADTLVADVPKRTSLTLATRLGGWPELLLVAVGVGGLGWAVVRSRRGGRAAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JHB8</accession>
    <name>A0A2M9JHB8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Polyketide cyclase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CG723_40395</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000033">
        <property type="protein sequence ID" value="PJN06278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN06278">
        <property type="protein sequence ID" value="PJN06278"/>
        <property type="gene ID" value="CG723_40395"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019587">
        <property type="entry name" value="Polyketide_cyclase/dehydratase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10604">
        <property type="entry name" value="Polyketide_cyc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PJN06278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="158" mass="18412" checksum="4B3F055A633E1E9C" modified="2018-04-25" version="1">MSGHTENSITIDAPIDLVWDVTNDIENWPQLFSEYASLEVLSREGDKTTFRLTMHPDDNGKVWSWVSERTIDRAKRSVRARRVETGPFAHMDIRWDYTETPEGTRMDWVQDFAMKPEAPVDDAWMTDNINRNSVTQMGLIRDRIERVARDRQNAAVSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JHE0</accession>
    <name>A0A2M9JHE0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Non-ribosomal peptide synthetase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CG723_39850</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CB01635</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pantetheine 4'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:47942"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Antibiotic biosynthesis.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000032">
        <property type="protein sequence ID" value="PJN06299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN06299">
        <property type="protein sequence ID" value="PJN06299"/>
        <property type="gene ID" value="CG723_39850"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00659"/>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043604">
        <property type="term" value="P:amide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017000">
        <property type="term" value="P:antibiotic biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008610">
        <property type="term" value="P:lipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901362">
        <property type="term" value="P:organic cyclic compound biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901566">
        <property type="term" value="P:organonitrogen compound biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030639">
        <property type="term" value="P:polyketide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010071">
        <property type="entry name" value="AA_adenyl_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001242">
        <property type="entry name" value="Condensatn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013217">
        <property type="entry name" value="Methyltransf_12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020802">
        <property type="entry name" value="PKS_thioesterase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001031">
        <property type="entry name" value="Thioesterase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00668">
        <property type="entry name" value="Condensation"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08242">
        <property type="entry name" value="Methyltransf_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00975">
        <property type="entry name" value="Thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00824">
        <property type="entry name" value="PKS_TE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="SSF47336"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01733">
        <property type="entry name" value="AA-adenyl-dom"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0045">Antibiotic biosynthesis</keyword>
    <keyword evidence="3 7" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Carrier" evidence="9">
        <location>
            <begin position="967"/>
            <end position="1042"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="9">
        <location>
            <begin position="2401"/>
            <end position="2476"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="9">
        <location>
            <begin position="3443"/>
            <end position="3518"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="9">
        <location>
            <begin position="4504"/>
            <end position="4579"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="2321"/>
            <end position="2346"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="7">
        <location>
            <position position="1002"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="7">
        <location>
            <position position="2436"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="7">
        <location>
            <position position="3478"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="7">
        <location>
            <position position="4539"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PJN06299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="4849" mass="521349" checksum="A2E5CB3DE98C3071" modified="2018-04-25" version="1">[encoded data, 4849 characters]</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JHM4</accession>
    <name>A0A2M9JHM4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_39505</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000031">
        <property type="protein sequence ID" value="PJN06352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN06352">
        <property type="protein sequence ID" value="PJN06352"/>
        <property type="gene ID" value="CG723_39505"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="178"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN06352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="226" mass="23257" checksum="4491CA85A9B6A702" modified="2018-04-25" version="1">MTGDGGGGGGGGKDLKTGGLALIAKGLTEALAELKELGMVGEAGAGRGFGDIALSGLDLGHEGLTGEFKSFCERWEWGVRSLVNEGNGFAVKTGLSAGTYYETEQYVEGSFKVVTNAAIGNPYASEEEVTQKGWGDIATSGAYGGVDYSKESFDQAMANSGQGWKDAGRDVMTSHTLGPAGLNPENLHNALGVSDDEYDQMLDDTFGPSPEERAKAAGQQQGGGEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JHR0</accession>
    <name>A0A2M9JHR0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Sugar ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CG723_39090</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CB01635</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000030">
        <property type="protein sequence ID" value="PJN06419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN06419">
        <property type="protein sequence ID" value="PJN06419"/>
        <property type="gene ID" value="CG723_39090"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="29"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="88"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="120"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="170"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="224"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="280"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="85"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PJN06419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="308" mass="33707" checksum="C327FFC2590FD1CB" modified="2018-04-25" version="1">MTTLQPPAAARPRPTGPPVRRARRSWTGWGFIGPFVLVFALVFLAPLAYSVYLSLFRTQLIGGTTFVGLDNYQQALQDGQFWDGVVRVGLFLLIQVPIMLGIALLVALAIDSGRLYGKDFFRITVFLPYAVPAVVATLMWGFMYGTRYGLVGDVNDAFGVKLPDPLSADLVLASIGNIVTWEFVGYNMLIFFAALRVVPHSLYEAAEIDGAGQWRVITAIKLPAIRGALVIATIFSIIGSFQLFNEPAILQKLAPNAITTDYTPNFYTYSLSFSGQQQNYSATVAIVMGVITMIVAYVVQLRGMRKGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JHX6</accession>
    <name>A0A2M9JHX6_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Chaperone protein ClpB</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11 13" type="primary">clpB</name>
        <name evidence="13" type="ORF">CG723_39345</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">CB01635</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homohexamer. The oligomerization is ATP-dependent.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Homohexamer; The oligomerization is ATP-dependent.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the ClpA/ClpB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000030">
        <property type="protein sequence ID" value="PJN06453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN06453">
        <property type="protein sequence ID" value="PJN06453"/>
        <property type="gene ID" value="CG723_39345"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042026">
        <property type="term" value="P:protein refolding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009408">
        <property type="term" value="P:response to heat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1780.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017730">
        <property type="entry name" value="Chaperonin_ClpB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019489">
        <property type="entry name" value="Clp_ATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036628">
        <property type="entry name" value="Clp_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004176">
        <property type="entry name" value="Clp_R_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001270">
        <property type="entry name" value="ClpA/B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018368">
        <property type="entry name" value="ClpA/B_CS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028299">
        <property type="entry name" value="ClpA/B_CS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041546">
        <property type="entry name" value="ClpA/ClpB_AAA_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07724">
        <property type="entry name" value="AAA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17871">
        <property type="entry name" value="AAA_lid_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02861">
        <property type="entry name" value="Clp_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10431">
        <property type="entry name" value="ClpB_D2-small"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00300">
        <property type="entry name" value="CLPPROTEASEA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01086">
        <property type="entry name" value="ClpB_D2-small"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81923">
        <property type="entry name" value="SSF81923"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03346">
        <property type="entry name" value="chaperone_ClpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51903">
        <property type="entry name" value="CLP_R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00870">
        <property type="entry name" value="CLPAB_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00871">
        <property type="entry name" value="CLPAB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 10" id="KW-0143">Chaperone</keyword>
    <keyword evidence="6 11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 9" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 11" id="KW-0346">Stress response</keyword>
    <feature type="domain" description="Clp R" evidence="12">
        <location>
            <begin position="3"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="87"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="418"/>
            <end position="532"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00026057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU362034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PJN06453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="880" mass="97916" checksum="6E97934DDBDFC787" modified="2018-04-25" version="1">MDMNRLTQKSQEALQEAQTIAGRMDQTEVDGEHLLLALLDQPDGLVPRLFDQAGADTKALRASLMSELSRRPKVTGPGATPGQVYVTQRLAKLLDTAEQEAKRLKDEYVSVEHLVLALADEGSRTAAGRLLKEHGIAKDAFLAALTRIRGNQRVTSATPEAAYEALEKYGQDLVAEARSGKKDPVIGRDAEIRRVMQILSRKTKNNPVLIGDPGVGKTAIVEGLAQRIVRGDVPEGLREKTIFSLDMSSLVAGAKYRGEFEERLQAVLSEVKAAEGRILLFVDELHTVVGAGGGAEGAMDAGNMLKPMLARGELHMIGATTLDEYRKHIESDAALERRFQQVMVDEPSVEDTVSILRGLRERLEVFHGVKIQDTALVAAATLSHRYISDRFLPDKAIDLVDEACARLRTEIDSMPAELDEITRRVTRLEIEEAALEKETDPASRKRLEELRRELSDLRAEADAMNAQWEAERQAIRRVQELRQELEQVRQEAEEAERNYDLNRAAELRYGKLTELERRLAAEEEALAAKQGETRLLREVVTEDEISEIVAAWTGIPVTRLQEGEREKLLRLDEILTERVIGQDEAVKLVTDAIIRARSGIRDPRRPIGSFIFLGPTGVGKTELAKALAAALFDTEESIVRLDMSEYQERHTVSRLVGAPPGYIGYEEGGQLTEAVRRKPYSVVLFDEVEKAHADVFNTLLQVLDDGRITDAQGRTVDFRNTVVIMTSNIGSAHLLDGVTPEGEIKPDARALVMGELQSHFRPEFLNRVDDVVLFKPLGMDQIKRIVELQFNDLRRRLAERQISVELTDQARELIAQQGFDPVYGARPLRRFISHEVETLVGRALIRGDVDDGSTIRVDAQNGELVVTYARPAQANHGMAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JID6</accession>
    <name>A0A2M9JID6_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">UmuC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CG723_37735</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CB01635</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the DNA polymerase type-Y family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000027">
        <property type="protein sequence ID" value="PJN06630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN06630">
        <property type="protein sequence ID" value="PJN06630"/>
        <property type="gene ID" value="CG723_37735"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009432">
        <property type="term" value="P:SOS response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036775">
        <property type="entry name" value="DNA_pol_Y-fam_lit_finger_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017961">
        <property type="entry name" value="DNA_pol_Y-fam_little_finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001126">
        <property type="entry name" value="UmuC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00817">
        <property type="entry name" value="IMS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11799">
        <property type="entry name" value="IMS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100879">
        <property type="entry name" value="SSF100879"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="SSF56672"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50173">
        <property type="entry name" value="UMUC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UmuC" evidence="3">
        <location>
            <begin position="14"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00025589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PJN06630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="324" mass="34451" checksum="A4EF69560ED696CA" modified="2018-04-25" version="1">MTTLYVRFLLPPVYEAALPQLIGLLGEFSPTVEALPPDAALVDLGGAVRYFGRDAVELAAVIRVRALALYGVECVIGAGPGPMLARMAARTASPGVTRVVPGDPGAVAEFLAGQPVAALPGVGAATARTLCEYGLDTLDRVAAAPQGTLQRLTTARIGRELHEKARGVDRTRVTPNAATRSTAAERPFPRDELDPYRHRRALLSLADELGARLRDGKQVCRSLTLTVRYADRSTTTRSRTLPEPTGHTTALSTAAYRMYEALGLQRARVRALALRAEGLRPVEGSACQLTFDPADEKARALEAVADRARARFGPGAIVPGRLAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JIH2</accession>
    <name>A0A2M9JIH2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Type IV secretion protein Rhs</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_38360</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000028">
        <property type="protein sequence ID" value="PJN06567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN06567">
        <property type="protein sequence ID" value="PJN06567"/>
        <property type="gene ID" value="CG723_38360"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045351">
        <property type="entry name" value="DUF6531"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001826">
        <property type="entry name" value="RHS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022385">
        <property type="entry name" value="Rhs_assc_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031325">
        <property type="entry name" value="RHS_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006530">
        <property type="entry name" value="YD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20148">
        <property type="entry name" value="DUF6531"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03527">
        <property type="entry name" value="RHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05593">
        <property type="entry name" value="RHS_repeat"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03696">
        <property type="entry name" value="Rhs_assc_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01643">
        <property type="entry name" value="YD_repeat_2x"/>
        <property type="match status" value="14"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6531" evidence="2">
        <location>
            <begin position="411"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="376"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1176"/>
            <end position="1196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN06567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="1572" mass="172772" checksum="8642B90FD9216822" modified="2018-04-25" version="1">MGIGDWADKGLGALEDGWDNGKKALGEGVEWGAHKLGDGLEYVGADWAADKVEDLGDSVASDLGAAVDEQQLGEAQQADELVHGDPGDIRASASHLKDFHKAFDKVSGGMRTLDSSHWKGRAADAFRKKFAMHPSKWLHAADACDKAGKALDSYADTVKWAQGQAQDAIDLYKKGKGASDKAVEAYNKRVDAYNSALKADQDPGPRPEPFKDPGAADVKHAREKLGEARRQRNEAGATATRAIKAALAHAPAEPPPLDRLKSEVTDGVQSTGTELTHVVGGVFKGTAGLLNFARGLNPEDPYNITHPAAYKQNINLTLAGLASTATHPDRAAKDAYQSLKKDPSEFFGRMLPEVFGSKGLGLAKSGLRAGVEHGMKEAAEAGARRSARRTLDEDPAEHSRELKSVEHKGTDPVDLATGKMFLPQTDVALPGTLPLVFTRRVESGYHLGRWFGPSWSSTVDQRLEIDSEGVVFVTADGLLLPYPHPAPGLPTLPTHGPRHPLDRVDDGYTITDPVTGRVWHFADRGTDLAVLEQIDDRNGNWLTFEYDAEGTPLGIVHSGGYQLKVTAEGGRVTSLHLAGAGADGSDEELIRYGYCENGHLTEVTNSSGLPLRFTYDDEGRVTSWTDTNDRSYTYEYDDQDRCVAEGGSEGHMSLRLAYAGPDPETGLRLTTTTTGEGHTRRFLINDAWQVIAETDPLGATTRYERDRYNRLLSQTDPLGHTTSFRYDEAGNLILAVRPDGREIKAEYDDHGLPIKVTGPDGTVHRQTYDECGNRTSVTGPTGQATRFTYDEAGRLTAVTDPLGHLTTVRCDGAGLPVSITDPLGAMTRYERDAFGRPVSITDPLGVTTRLEWTGEGRLSRQTAPDGTSESWTYDGEGNCTTHTDAMGGLSSYEYTHFDLLTARTGPDGVRYEFAHDHELRLTQVTNPQGLTWGYTYDPAGRLISETDFDDRILTYAHDTAGRLTSRTNALGERITFERNELGRTTRKDAAGRVTTYAYDLTDQLAQATDPDATLTLLRDRHGRLRSETVNGRVLTYAYDELGRRTGRTTPTGATSSWTYDAVGNRSQMTMSGRTIDFAYDQAGRELARHIGDSLTVENAFDELGRLTTQSVTASDTTGHRRIQSRSYTYRADGNLIGIDDQLAGSRRFDVNEAGRVTAVHAANWTEAYAYDEAGNQTAASWPGDHPGHEATGPRTYTGTRITRAGRVRYEHDALGRVTLRQKARLSRKPDTWRYEWDAEDRLTTTVTPDGTCWRYTYDPLGRRTAKLRLAADGETVVERVDFTWDGTTLCEQTTTSAELPNPVTLTWDHQGLRPIAQTERISAAGADAPQSEIDSRFFAIVTDLVGTPNELVDEQGEIAWHTRSTLWGTTAWSSDSTTYTPLRFPGQYFDPETGLHYNYFRHYDPETARYLGPDPLGLEPNPNNVTYVENPHTWVDPLGLAPDACPNNVALGIRKEGDLRNFAESRKFTHFLDDTREGALSRVRDVAHEQPHVRLHVVMDGFRGLKEQMTDNAAELFEAAYSRGKGDNWYTTEREMAIVGDAVKWGNRPWDSITFYHKGIEVPVPHPVSLGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JIL3</accession>
    <name>A0A2M9JIL3_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">FtsX domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CG723_38590</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CB01635</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000028">
        <property type="protein sequence ID" value="PJN06607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN06607">
        <property type="protein sequence ID" value="PJN06607"/>
        <property type="gene ID" value="CG723_38590"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003838">
        <property type="entry name" value="ABC3_permease_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02687">
        <property type="entry name" value="FtsX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014689683" description="FtsX domain-containing protein" evidence="8">
        <location>
            <begin position="45"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="327"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="376"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="445"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="domain" description="FtsX" evidence="9">
        <location>
            <begin position="353"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="65"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="136"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="70"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PJN06607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="485" mass="49308" checksum="DA90B4458919A762" modified="2018-04-25" version="1">MFFTYLRRELRRRRKAALVVASGLALGIALVIVVNSVSSGMNQAQDKVLQSLYGLGTDMTVTKAAEAPKSGETGRPRFEFGAKDDGEEQSSDRVMVQGFQTLASSTVTKVAGQKGVTDSVGGLSLQVMKVSGEFKRGQFKQDQSGGATRQGGPGGSGGEPQGRVEGGGASFDVNSYSVYGTDVAKQGLGPLTSSKVTKGRTFKTSETDAKVAVADTSYAKEKKLALGGTVKIKGVKYKLIGIATPDSGDAAANLYVPLKQAQTLAGAKDKITTVYVKATDSQQISAVKATIQKNISGTTVTTSADLADTVSGSLSTASDLAANVGKWLSIAVLVAAFLVAGLLTSSAVSRRVREFGTLKALGWKSGRVTRQVVGEAVVNGLVGGVLGIAVGLAGAYAVTAISPTLTAELGSGAGGGARSGGLAMGGPGMRQAAGKTLDIALRAPVSATTITLAVGLAVAGGLIAGAFGGWRASRLRPADALRRVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JIL4</accession>
    <name>A0A2M9JIL4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Glycosyl transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CG723_37170</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000026">
        <property type="protein sequence ID" value="PJN06719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN06719">
        <property type="protein sequence ID" value="PJN06719"/>
        <property type="gene ID" value="CG723_37170"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044249">
        <property type="term" value="P:cellular biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901576">
        <property type="term" value="P:organic substance biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028098">
        <property type="entry name" value="Glyco_trans_4-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13439">
        <property type="entry name" value="Glyco_transf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_4-like_N" evidence="5">
        <location>
            <begin position="13"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="domain" description="Glycos_transf_1" evidence="4">
        <location>
            <begin position="202"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="397"/>
            <end position="424"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF13439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PJN06719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="424" mass="46212" checksum="C09FE534C6D93D91" modified="2018-04-25" version="1">MKIVFLLHNAYAIGGTVRTTLNLAAALAGRGGHEVEIVSMSRHREVPRFTVDPAVSLVPLVDTRIGGVDTRYAAYEEPARDFPAAEKRRKQYTRLHDLRVREYLERCDADVVIGTRPGINVYLAMYGPRTALRIGQEHLRHDAHSKKLRAVLARHYRSLDAVVTMTSADAEVYRARMALPGVQVLSVPNIVPEAPCPPSDGAAKVIASAGRLAPGKRFDLLLEAFAAVAAQEPEWQLRIYGGGPEEAKLRDLIAGLGLTGRAHLMGARSPIEPEFAKASIVVSASDAESFGMTLVEAMRCGVPVVSTDAPLGPAEIITDGVDGRLVPLGDARALAEAVVGLIDDAPRRHAMARAAFASARRYDPDPIVARYELLFAELRETRRLRSWQRLRSRAADWARRKARSTHGPARTASARGARSDPRPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-09-29" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JJA0</accession>
    <name>A0A2M9JJA0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CG723_36225</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000024">
        <property type="protein sequence ID" value="PJN06944.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN06944">
        <property type="protein sequence ID" value="PJN06944"/>
        <property type="gene ID" value="CG723_36225"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037883">
        <property type="entry name" value="Knr4/Smi1-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160631">
        <property type="entry name" value="SSF160631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PJN06944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="166" mass="18356" checksum="83E1A38A3AF81F21" modified="2018-04-25" version="1">MVDAITDGITAGPDQLQGLPAEAVLAVERDQQAPMADAYREFLSLIGGGAGRFMQGEAVYHPHVLGLGTAALELLEENESPFLFEPTDRVFFMHQGYQFEFMRGTGPDPEVWSYSEGEHANVPVHSYASFTDWLRATAEAAIPAWKHHVETVREEINADGSITLHW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JJA9</accession>
    <name>A0A2M9JJA9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">FUSC family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_36330</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000024">
        <property type="protein sequence ID" value="PJN06961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN06961">
        <property type="protein sequence ID" value="PJN06961"/>
        <property type="gene ID" value="CG723_36330"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="72"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="100"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="125"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="176"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="477"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="500"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="521"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="558"/>
            <end position="574"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN06961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="880" mass="93557" checksum="BC552CA595EF7D0A" modified="2018-04-25" version="1">MTTPDTLPHTSTALGTAAVDLAPHRVAGPRRWWDWVLAADPGLGQLQAGWRSLVAMVTSLAVGYGMAQALSIPVMIGMMVAGMMGLMSAFAVAENSWDRLARAILWMPFPYTAVLWLCATLNGERVPQMVLMIAALALTFFLARFGPMALLTGMMLFNGLMVGMLAGIPAALVGKAFAVALVSAAAVLVTRLLLCYPMPREDFLRTQRAFVVEARRVADAAVDALDPDADRKRAVRRTNRALRRLNITTVTIDGRLAQPEVAADPAAAELLHRHLFDAELALRGIGQAAADLTRLPVPEPLREALAVGLVLARDTPLGQAEGLRPAAAHIQDRAETILRDAAAPADHVEAAVLARRVGHLLDSLAASLDSWLTLGHTTATGPGDVPFQPTVVLENNRLPGSAGPARRVLAAGSESGWRRVIPFVRVPAHAAVAAAIVCPISDAIDPARFYWGLVGVMITLFGTNTTHERLRKFGHRMVGTAVGAVLGLVILHLIGRDHVYATLVVIVAGLTLGAWGMQRAYACWVVGLVVALVQLYALSTPDNGMNHLLGERILDNGLGVLVATACAALIFPLSRGTVVKEAERGYVDALAQVVMQVEQRWSRPDEPVRLRGAARAVDAALSQVQSVVRPLVRMPVGVRGPAADHRVALLATATGHARALAVAADIDVDLSPRLAERARLITATLTASLRELDQFFASGEAEGAGAWRRVGPLIRELEAELAPAPQGPRARSLGTALRELDALDETLAAYAEQAGLPVAAEGRTAQTPASPMQRRTRALMAAWNEPQQHRAAAPTGTARVEGRVHCAAHPEGCPAWVTMISSRGKRLAKSQVTVGSYAMEALPPGTHTLVISASRHTPRAELVTVDGPSGTVLHDVELRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JJC1</accession>
    <name>A0A2M9JJC1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CG723_36395</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CB01635</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000024">
        <property type="protein sequence ID" value="PJN06969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN06969">
        <property type="protein sequence ID" value="PJN06969"/>
        <property type="gene ID" value="CG723_36395"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045621">
        <property type="entry name" value="BPD_transp_1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19300">
        <property type="entry name" value="BPD_transp_1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="9"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="99"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="132"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="175"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="229"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="275"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="95"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PJN06969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="308" mass="33205" checksum="C0BC6905450E960A" modified="2018-04-25" version="1">MLRFALRRLLIMIPIAVIVTFLVYAMVFALPGDPIRALSGQKPLAESVIAAKRAYYHLNDPLFVQYLHFMGNLLKGDLGQTFDGQDIGEQLALRWPVTLQLGLTALAIQLVLGLVSGVYAGWRRDGLVDRALLGATLGVLAVPGLVAMFFAQSFFAVELSWFPVSGATDGWPGSYLLPATVLGVLGFAGLARVTRTSIAEVASADFVRTARAKGLAPNRILWGHVLRNAMLPVITYIGLDLAGILGGAIITEGIYNLNGIGQFMFRSIAMKEGGVVVTLSTVLLLGYMLVNLVVDLLYGLLDPRVRHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JJQ2</accession>
    <name>A0A2M9JJQ2_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Histidine kinase</fullName>
            <ecNumber evidence="3">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CG723_35880</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CB01635</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="3"/>
    <dbReference type="EMBL" id="NNBL01000023">
        <property type="protein sequence ID" value="PJN07108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN07108">
        <property type="protein sequence ID" value="PJN07108"/>
        <property type="gene ID" value="CG723_35880"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00672">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00304">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="31"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="158"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="9">
        <location>
            <begin position="179"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="8">
        <location>
            <begin position="243"/>
            <end position="445"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PJN07108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="459" mass="49176" checksum="70266E00188E7284" modified="2018-04-25" version="1">MRGAAATVRARLGLPLRLPLRRLRPALHTGVRWKISVAIALVGALVALALSLVVHNAARVSMLDNARDVQDERIQFVARQYEATGRGLPVGFKVDDPGIPPDLRKRAMAGRRATFVSEQAGGVPDIWAAVPLGDGRLLSVHTRFTDRSATVMKDLDQALIIGSISVVFGGCALGVLIGGQVSRRLRKAALAAREVAQGRTDVRVGDAIGGVVRDETDDLAQAVDAMADALKQRLEAERRVTADIAHELRTPVTGLLTAAELLPPGRPSELVKDRAQAMRTLVEDVLEVARLDSAAERAELQDLLLGEFVTRRIGARHADVRVSVVHESEVTTDPRRLERILFNLLANAAKHGKPPVEVSVEGRVVRVRDHGPGFPEELLDEGPSRFRTGAADRAGHGHGLGLTIAAGQARVLGARLTFRNVRPPGAPSGTPAEGAVAVLWLPEHAPTNTGSFPMLRLPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JK01</accession>
    <name>A0A2M9JK01_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Sulfurtransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_35000</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000022">
        <property type="protein sequence ID" value="PJN07200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN07200">
        <property type="protein sequence ID" value="PJN07200"/>
        <property type="gene ID" value="CG723_35000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00581">
        <property type="entry name" value="Rhodanese"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00450">
        <property type="entry name" value="RHOD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52821">
        <property type="entry name" value="SSF52821"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014902915" evidence="1">
        <location>
            <begin position="24"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodanese" evidence="2">
        <location>
            <begin position="48"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN07200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="161" mass="16698" checksum="CCAC3609464F1719" modified="2018-04-25" version="1">MTATTTVTPNSVLRVPPASPAAAAAYFGASLAFHADVSDVASALAADGDPGFVVIDTRSTASWDQGHVPGAVHLPAALIAEQAEQLLDRSVPVVTYCWGPGCNGATRAALALAELGFQVKEMLGGFEYWAREGFAYETWEGPAQRDADPLTAPVDSDDCGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JK08</accession>
    <name>A0A2M9JK08_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GntR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_34950</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000022">
        <property type="protein sequence ID" value="PJN07192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN07192">
        <property type="protein sequence ID" value="PJN07192"/>
        <property type="gene ID" value="CG723_34950"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07377">
        <property type="entry name" value="WHTH_GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1410.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028978">
        <property type="entry name" value="Chorismate_lyase_/UTRA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011663">
        <property type="entry name" value="UTRA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
        <property type="entry name" value="GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07702">
        <property type="entry name" value="UTRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00035">
        <property type="entry name" value="HTHGNTR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00345">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00866">
        <property type="entry name" value="UTRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64288">
        <property type="entry name" value="SSF64288"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50949">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH gntR-type" evidence="1">
        <location>
            <begin position="11"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN07192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="255" mass="27483" checksum="7477D5EF17DCD8EE" modified="2018-04-25" version="1">MGTTQLETAPEPKYWHLKTVLTEALDSEFVVGEILPNERDLAARFGVARATLRQALEQLELEGRLQRRRGVGTTVAPPRVGVAVDSSDDQEWPGDADGDAWQAVDSELAVPPAAVARILGTAPDERVHRVRRTRVSHGQPVAAELLYVPSSSVPELSAIDAPSGPSRARSVLRELRRLGLEGQDRAVELGSARADDAKELDRLPGAPVLVVTTRFFSEGETAAVSVATYRADTCRLTFGDSGGVEIHHGPDRRAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JKG9</accession>
    <name>A0A2M9JKG9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Double-stranded uracil-DNA glycosylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_34910</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000022">
        <property type="protein sequence ID" value="PJN07277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN07277">
        <property type="protein sequence ID" value="PJN07277"/>
        <property type="gene ID" value="CG723_34910"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000700">
        <property type="term" value="F:mismatch base pair DNA N-glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006285">
        <property type="term" value="P:base-excision repair, AP site formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd10028">
        <property type="entry name" value="UDG-F2_TDG_MUG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015637">
        <property type="entry name" value="MUG/TDG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005122">
        <property type="entry name" value="Uracil-DNA_glycosylase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036895">
        <property type="entry name" value="Uracil-DNA_glycosylase-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12159">
        <property type="entry name" value="PTHR12159"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03167">
        <property type="entry name" value="UDG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00986">
        <property type="entry name" value="UDG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52141">
        <property type="entry name" value="SSF52141"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UDG" evidence="1">
        <location>
            <begin position="18"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN07277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="189" mass="20200" checksum="E6399B7A75ECDA46" modified="2018-04-25" version="1">MTRLTPADLEAARDRIVPDVIASGLSVLFCGINPGLMTAATGHHFARPGNRFWPVLHLSGFTPRQLAPAEQEELLSYGLGITNVVARATARADELSGQEYRDGGRLLTAKVERLRPRWLAVVGVTAYRSAFGEPKARIGPQERMIGGTRVWALPNPSGLNAHWTAATMAEEYGRLRAAASGDDGAGLGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JKH2</accession>
    <name>A0A2M9JKH2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_34540</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000021">
        <property type="protein sequence ID" value="PJN07371.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN07371">
        <property type="protein sequence ID" value="PJN07371"/>
        <property type="gene ID" value="CG723_34540"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN07371.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="508" mass="55291" checksum="CEE4C0942DB2AE8D" modified="2018-04-25" version="1">MTSPATTESVPPQLSAGPRPAPGPAADEGLARRLRALACTAPLHDLDVRKANLAGEYSGYGMAEVALSAIDLVTLNMDFDTGADHEQIVARLIPRVGAQAPQRPAAEHERVARWVLENLINVGSVDRGFRAVYGTFAPDGSYVRRDYDFKLIEEVAGYGGSVYLRTTDEAVNVLVGALDTDVTSAQIAAEVKLEVLINRGRLADAQLAAEQARYRTVQYSETLRRALDATRRNVRAVDWLNAVPDMIAEALDHVADRYRHENAILTNIRKARDESEDPEHKRRAAELVDIVKDCIRRHTQLQSRLLEAGPLFRAEQDRQAFAAPSARAGLDLYGQLVAPLLPLPVEQASRVTDAFFARGTGMRTPVSVRVGDLIDILLTPPQEREHLGVEMPEPDLIATPDDSRFSEEQLASAMELLDLPSDAPRRLSGLLAEARRRDPELPYLVALLSVHAASPPVGTAYRQGEEKLLFAVDDGTELDDPEFGGADLIVGTALLDAAGMAADRTEAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JLK3</accession>
    <name>A0A2M9JLK3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Protein phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_32315</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000018">
        <property type="protein sequence ID" value="PJN07756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN07756">
        <property type="protein sequence ID" value="PJN07756"/>
        <property type="gene ID" value="CG723_32315"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07228">
        <property type="entry name" value="SpoIIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00331">
        <property type="entry name" value="PP2C_SIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="61"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="domain" description="PPM-type phosphatase" evidence="2">
        <location>
            <begin position="111"/>
            <end position="358"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN07756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="377" mass="40589" checksum="F51C41D9FC86853F" modified="2018-04-25" version="1">MIRNHPRTPSRPPRTFFRSRLARSRSLRVRRALDLVLPTAWGAVAITFKLACPLAQQTGLGARIASSAVFFAVGTGLILHVRRGLQRELRQLRRIAGAAQNVLLRPLPPRIDGLAVAAGQLSADRGATVGGDLYEAIATDHGVRVVMGDVRGHGLDALATVAAVLGSFREAAHDEAELTCVLRRLERAMARHLRERSRDEHPAAGGADPVSPVAEEFVTVLLLEIRQDGEVLALNCGHPWPYLLRSHVGPAAVPRGYAELVVGGEPLPPLGPFPLPAELPVVACGRLLPGEGLLLHTDGLEDARDARGRFFPLPDALAEAVRVQPVVPKAVIRTVYAQLLRHAGGLPTDDAALLVLRNDRKRVPSQHGELRVHSAAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JLK6</accession>
    <name>A0A2M9JLK6_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 6 7">50S ribosomal protein L20</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">rplT</name>
        <name evidence="8" type="ORF">CG723_32340</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CB01635</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5 6 7">Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6 7">Belongs to the bacterial ribosomal protein bL20 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000018">
        <property type="protein sequence ID" value="PJN07761.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN07761">
        <property type="protein sequence ID" value="PJN07761"/>
        <property type="gene ID" value="CG723_32340"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07026">
        <property type="entry name" value="Ribosomal_L20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1900.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00382">
        <property type="entry name" value="Ribosomal_L20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005813">
        <property type="entry name" value="Ribosomal_L20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035566">
        <property type="entry name" value="Ribosomal_protein_L20_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10986">
        <property type="entry name" value="PTHR10986"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00453">
        <property type="entry name" value="Ribosomal_L20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00062">
        <property type="entry name" value="RIBOSOMALL20"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74731">
        <property type="entry name" value="SSF74731"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01032">
        <property type="entry name" value="rplT_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00937">
        <property type="entry name" value="RIBOSOMAL_L20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6 7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 6 7" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="6 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6 7" id="KW-0699">rRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00021194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00024775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PJN07761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="128" mass="14482" checksum="6586E8E57533AF45" modified="2018-04-25" version="1">MARVKRAVNAHKKRRAVLEAAKGYRGQRSRLYRKAKEQVTHSLVYNYNDRKKRKGDFRRLWIQRINAAARENGMTYNRLIQGLNAANIEVDRKILAELAVNDPNAFAALVEVAQKALPADVNAPKAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JM55</accession>
    <name>A0A2M9JM55_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_31740</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000017">
        <property type="protein sequence ID" value="PJN07938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN07938">
        <property type="protein sequence ID" value="PJN07938"/>
        <property type="gene ID" value="CG723_31740"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="60"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN07938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="80" mass="8964" checksum="CC3A587099F30F58" modified="2018-04-25" version="1">MAKATASVRRGTGSWRVGHRLDGSLIDVALAAGSGFHRMALLKRHTDLNSEFYARVRAETPHVPETERRLRKAVSDLRRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JM62</accession>
    <name>A0A2M9JM62_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glyoxalase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_30175</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000016">
        <property type="protein sequence ID" value="PJN07970.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN07970">
        <property type="protein sequence ID" value="PJN07970"/>
        <property type="gene ID" value="CG723_30175"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004360">
        <property type="entry name" value="Glyas_Fos-R_dOase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00903">
        <property type="entry name" value="Glyoxalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VOC" evidence="1">
        <location>
            <begin position="4"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN07970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="144" mass="15072" checksum="CD870FDCD9E6839B" modified="2018-04-25" version="1">MEQRVSLITLAVADLGCSRAFYESLGWRGQEVEETVFFQAGGLGLVLWGRDKLALDCGLDSADGTGFGGIVLAHNMRSPKEVDALLTAAQQAGGTITKPARATPYGGYAGCFADPDGHLWEIAHNPGFPLAEDGSLTIPAFGSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JM89</accession>
    <name>A0A2M9JM89_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">MDMPI_N domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_30325</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000016">
        <property type="protein sequence ID" value="PJN07995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN07995">
        <property type="protein sequence ID" value="PJN07995"/>
        <property type="gene ID" value="CG723_30325"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017517">
        <property type="entry name" value="CHP03083_actinobac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034660">
        <property type="entry name" value="DinB/YfiT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024344">
        <property type="entry name" value="MDMPI_metal-binding"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11716">
        <property type="entry name" value="MDMPI_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109854">
        <property type="entry name" value="SSF109854"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03083">
        <property type="entry name" value="TIGR03083"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MDMPI_N" evidence="2">
        <location>
            <begin position="10"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="74"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="136"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="88"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF11716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN07995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="173" mass="19756" checksum="FB39D7A29FB6524B" modified="2018-04-25" version="1">MTDDVWELVHAEREALIDDLAHLKDDQWLKSSLCDGWTVHDVLAHLIDTARTTRLGFVKDLTLARFDFNRQNTRGVERERRSTPQETLERFRQVASRTSTPPAPLDSRLVEEVVHGEDIRRPLGLTRAYPTQAAVRSLRLQTRTPASFGSLRRRQEGHPQDATPPGFDPGRPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JMD6</accession>
    <name>A0A2M9JMD6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Tripartite tricarboxylate transporter TctA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_30610</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000016">
        <property type="protein sequence ID" value="PJN08040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08040">
        <property type="protein sequence ID" value="PJN08040"/>
        <property type="gene ID" value="CG723_30610"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002823">
        <property type="entry name" value="DUF112_TM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01970">
        <property type="entry name" value="TctA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="45"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="108"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="147"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="170"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="200"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="316"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="358"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="391"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="471"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="498"/>
            <end position="519"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN08040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="519" mass="53970" checksum="F3199ECF7FDB61B0" modified="2018-04-25" version="1">MDVLSHLGDGFANAFSPVHLLLAFAGCLLGSLVGVLPGLGPATTVALLLPVTYVVDPVGALVLFAGIYYGGMYGGSTTAILLNVPGETASVPTTLEGFPMARAGRAGAALATAAIGSFVAGTISTVGITFAGPAFSAIAEHIQPAEYFAVMVLAFATVTAVVAEAPLRGLCSLFLGLAIGLVGIDSLTGQARYTFGVPELFDGIALVAVAVGLFAIAEALYTAARLRRAPDPDPLPLRGRIGMTRDDWRRSWKPWLRGTALGLPIGALPAGGAEIPTFLSYNLERRLSKHKQQFGKGAIEGVAGPEAANNAAFSGVLVPLLTLGIPTSATASMLLIAFQMYNVQPGPQLFETQPTLVWTLIASLYIGNVVLLALNLPMIPLWVKLLKIERPLLTAGILLFAALGVYALSQSPFDLGVALAFGVLGFLMRRTGYPVAPLVLGAVLGPLTETQFRRALTLAEGDWTVFITRPLSAAILVLAALALIGPLLMRLVRTPAPDDGEADVTVPEDNHPAGNAAPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JMU5</accession>
    <name>A0A2M9JMU5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CG723_29790</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000015">
        <property type="protein sequence ID" value="PJN08198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08198">
        <property type="protein sequence ID" value="PJN08198"/>
        <property type="gene ID" value="CG723_29790"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008171">
        <property type="term" value="F:O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002935">
        <property type="entry name" value="SAM_O-MeTrfase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01596">
        <property type="entry name" value="Methyltransf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51682">
        <property type="entry name" value="SAM_OMT_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 5" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PJN08198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="232" mass="25084" checksum="D822DBB14E4D233B" modified="2018-04-25" version="1">MCEFPPPTDTVTRRQPRGQERAITGNRQTSWAFADAFVAEDDALRWARDRAREAGTRPVSPGAGAALRMLAATVGAKAVAEIGTGTGVSGIHLLHGMRPDGVLTTVDPEPERQQFAREAFRAAGFASNRARFIPGRALDVLPRLADSGYDLVFCDGDRTECLDYLAESLRLLRPGGLVCFEGVFADGRTVDSGPQPVEVLRMRELLRAVREAQDLVPSLLPVGDGLLCAVKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JMV0</accession>
    <name>A0A2M9JMV0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Succinyl-diaminopimelate desuccinylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_29755</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000015">
        <property type="protein sequence ID" value="PJN08191.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08191">
        <property type="protein sequence ID" value="PJN08191"/>
        <property type="gene ID" value="CG723_29755"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009014">
        <property type="term" value="F:succinyl-diaminopimelate desuccinylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009089">
        <property type="term" value="P:lysine biosynthetic process via diaminopimelate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036264">
        <property type="entry name" value="Bact_exopeptidase_dim_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002933">
        <property type="entry name" value="Peptidase_M20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011650">
        <property type="entry name" value="Peptidase_M20_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010174">
        <property type="entry name" value="Succinyl-DAP_deSuclase_DapE"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07687">
        <property type="entry name" value="M20_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01546">
        <property type="entry name" value="Peptidase_M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55031">
        <property type="entry name" value="SSF55031"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01900">
        <property type="entry name" value="dapE-gram_pos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="M20_dimer" evidence="1">
        <location>
            <begin position="170"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN08191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="359" mass="38636" checksum="41A41F0AFDE397D6" modified="2018-04-25" version="1">MDLTALDLTRDAALLTAQLVDFASPSGQEKPLADAIETALRALPHLTVDRYGNNIVARTNLGRGERVILAGHIDTVPIADNVPSRLDEDGILWGCGTSDMKSGVAVQLRIAQTVTEPNRDLTFVFYDNEEVAAHLNGLGHVAEAHPDWLEGDFAILLEGTDGEVEGGCQGTLRVILTTKGERAHSARAWMGSNAVHKAAPILERLAAYEPRKPVVDGLQFHEGLNAVRIEGGVATNVIPDACSVTVNFRYAPDRSAEEAEAFVRDFFAGCDIDDYVVDDHTGGARPGLDHPAAAAFMAAVGGKARPKFGWTDVSRFSALGVPAVNYGPGDPIFAHKRDERVDTRKILAAEERLRSWLTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JMY5</accession>
    <name>A0A2M9JMY5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Peptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CG723_29975</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000015">
        <property type="protein sequence ID" value="PJN08230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08230">
        <property type="protein sequence ID" value="PJN08230"/>
        <property type="gene ID" value="CG723_29975"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013595">
        <property type="entry name" value="Pept_S33_TAP-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08386">
        <property type="entry name" value="Abhydrolase_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014922449" evidence="3">
        <location>
            <begin position="28"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="domain" description="Abhydrolase_4" evidence="4">
        <location>
            <begin position="409"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="44"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PJN08230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="514" mass="54284" checksum="625D4DFBB708B0CF" modified="2018-04-25" version="1">MPNPFRPRAAAMAATAVLLASALAACGSDTNDVDLRSQSLSWKDCPAPSESEGGGPAPSPLPGGATWQCATMKTPLDWDKPEGDTIGLALIRAKSSGAKDKRIGSLIFNFGGPGGSGVTTLPAFGSEYTKLRTRYDLVSFDPRGVGRSDGVKCENDEQLDKYFQQDAIPDNTAQTKKLVSNVTQFNDACERNSGQVIPHVATTGAARDMDLMRQVLGDDKLHYFGISYGTELGGVYAHLFPENVGRAVFDGVVDPTQNSEESSLGQAKGFQLALDNYAKDCTSKVEDCPVGDTPAEVKAKIAKLLKDLDSKPIPGVFPRELTQTAATNGIAQSLYSKDFWEYLTEGLAQAYEGDGKILMLLSDSMNGRNEDGKYSNLQAANVAVNCADDKPRYTPAYVRSKLPEFRAASPLFGDFLAWGMLSCTDWAVAGAADHPDVSAAGSAPIVVVGNTGDPATPYEGAKKMVGALGDGVGVQVTYEGQGHGAYDSGNKCVRGAVDSYLLNGTVPKAGTVCK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JN23</accession>
    <name>A0A2M9JN23_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CG723_29840</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000015">
        <property type="protein sequence ID" value="PJN08266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08266">
        <property type="protein sequence ID" value="PJN08266"/>
        <property type="gene ID" value="CG723_29840"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PJN08266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="166" mass="17626" checksum="185234C510374C80" modified="2018-04-25" version="1">MDRALVEEATKKSGLVWVRGTSGPERALWHVWHEGAANLVGDGPGEQPLPGLSDGGAATVTVRSKDKGGRLVSWTAGVVELAPHSEGWEAAVAELKGKRLNAPDGEAMPERWARECRVLRLEPTGSTVPPSSDALAAAPLATTATTRHEAPAALPHLLLRRKRRGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JN37</accession>
    <name>A0A2M9JN37_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Endonuclease III</fullName>
            <ecNumber evidence="10">4.2.99.18</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">DNA-(apurinic or apyrimidinic site) lyase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10 13" type="primary">nth</name>
        <name evidence="13" type="ORF">CG723_28165</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">CB01635</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>2'-deoxyribonucleotide-(2'-deoxyribose 5'-phosphate)-2'-deoxyribonucleotide-DNA = a 3'-end 2'-deoxyribonucleotide-(2,3-dehydro-2,3-deoxyribose 5'-phosphate)-DNA + a 5'-end 5'-monophospho-2'-deoxyribonucleoside-DNA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:66592"/>
            <dbReference type="Rhea" id="RHEA-COMP:13180"/>
            <dbReference type="Rhea" id="RHEA-COMP:16897"/>
            <dbReference type="Rhea" id="RHEA-COMP:17067"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:136412"/>
            <dbReference type="ChEBI" id="CHEBI:157695"/>
            <dbReference type="ChEBI" id="CHEBI:167181"/>
            <dbReference type="EC" id="4.2.99.18"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="10">Binds 1 [4Fe-4S] cluster.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the Nth/MutY family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.99.18" evidence="10"/>
    <dbReference type="EMBL" id="NNBL01000014">
        <property type="protein sequence ID" value="PJN08281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08281">
        <property type="protein sequence ID" value="PJN08281"/>
        <property type="gene ID" value="CG723_28165"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140078">
        <property type="term" value="F:class I DNA-(apurinic or apyrimidinic site) endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019104">
        <property type="term" value="F:DNA N-glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006284">
        <property type="term" value="P:base-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00056">
        <property type="entry name" value="ENDO3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1670.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00942">
        <property type="entry name" value="Nth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011257">
        <property type="entry name" value="DNA_glycosylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004036">
        <property type="entry name" value="Endonuclease-III-like_CS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003651">
        <property type="entry name" value="Endonuclease3_FeS-loop_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004035">
        <property type="entry name" value="Endouclease-III_FeS-bd_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003265">
        <property type="entry name" value="HhH-GPD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023170">
        <property type="entry name" value="HhH_base_excis_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000445">
        <property type="entry name" value="HhH_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005759">
        <property type="entry name" value="Nth"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10576">
        <property type="entry name" value="EndIII_4Fe-2S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00633">
        <property type="entry name" value="HHH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00730">
        <property type="entry name" value="HhH-GPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00478">
        <property type="entry name" value="ENDO3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00525">
        <property type="entry name" value="FES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48150">
        <property type="entry name" value="SSF48150"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01083">
        <property type="entry name" value="nth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00764">
        <property type="entry name" value="ENDONUCLEASE_III_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01155">
        <property type="entry name" value="ENDONUCLEASE_III_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 10" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="4 10" id="KW-0227">DNA damage</keyword>
    <keyword evidence="8 10" id="KW-0234">DNA repair</keyword>
    <keyword evidence="10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="13" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="9 10" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 10" id="KW-0408">Iron</keyword>
    <keyword evidence="7 10" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="10" id="KW-0456">Lyase</keyword>
    <keyword evidence="3 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-0540">Nuclease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ENDO3c" evidence="12">
        <location>
            <begin position="128"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="316"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="70"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="277"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="284"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="287"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="293"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PJN08281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="349" mass="36763" checksum="03D1B1457EF84B6F" modified="2018-04-25" version="1">MTAGRNSAVGEQAPAAPEKAAKGVKQARGVGDGAGGAAASAGKGAGGGVGSGGKRAAVKKAGAAKPVKKAAAAKSDKPPKKAAAKPESRTALVRRARRINRELAEVYPYAHPELDFENPFQLLVATVMSAQTTDLRVNQTTPALFARYPTPEDLAAANPEDVEELIRPTGFFRAKTKSIMGLAAALRDEFGGEVPGRLEDLVKLPGVGRKTAFVVMGNAFGRPGITVDTHFGRLVRRWKWTEETDPDKVEKAIGELFPKSDWTMLSHHVIFHGRRICHARKPACGACPIAPLCPAYGEGETDPEKAKKLLKYEKGGFPGQRLKPPQSYLDAGGIPAPPLGATAPPATGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JNG7</accession>
    <name>A0A2M9JNG7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_28970</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000014">
        <property type="protein sequence ID" value="PJN08412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08412">
        <property type="protein sequence ID" value="PJN08412"/>
        <property type="gene ID" value="CG723_28970"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025498">
        <property type="entry name" value="DUF4389"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14333">
        <property type="entry name" value="DUF4389"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="44"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="128"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="157"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="222"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN08412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="265" mass="28306" checksum="B496148C90F2AEA0" modified="2018-04-25" version="1">MEPHYGTVPLVPGAEALPELDIPHPGRQNRLFVLVRLLLLLPHLVVLALLSVVAFFAVVAGWFAALLIGRLPDPVERYLAGFLGYDTRVNASAMLLTGRYPPFEFGEPMGYPVRVRVLRSVHLNRLAVLLRLLLVIPAALVGAIATAGWWAVSVLSWLVVLLLGRMPLPLFEATAAVLRYRMRLNAYLLLLTPAYPKRLFGDQSAPDAVVGTIAGPSATRPLFLGAGAKMLVGAFLVLGLAGGAVNSSRYGADGSAAVQASLPGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JNL9</accession>
    <name>A0A2M9JNL9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ion channel protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_29235</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000014">
        <property type="protein sequence ID" value="PJN08459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08459">
        <property type="protein sequence ID" value="PJN08459"/>
        <property type="gene ID" value="CG723_29235"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006813">
        <property type="term" value="P:potassium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013099">
        <property type="entry name" value="K_chnl_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003148">
        <property type="entry name" value="RCK_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07885">
        <property type="entry name" value="Ion_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02254">
        <property type="entry name" value="TrkA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51201">
        <property type="entry name" value="RCK_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="39"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="102"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="domain" description="RCK N-terminal" evidence="2">
        <location>
            <begin position="147"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN08459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="368" mass="40067" checksum="02E95278A5E7D642" modified="2018-04-25" version="1">MFHVKLPGHDAMARQDDEKVVARQVKLPKRVVERPLRQVARRLIVALAVLVATAFIVWIDRSGYSDNSDNSVDLLDAFYYATVTLSTTGYGDITPVSDGARIVNILVITPLRVLFLIILVGTTLEVLTERTREEWRLNRWRSNLRDHTVVVGFGTKGRSAIQTVCATGLKADQVVVVDPSSKVIEAATAHGFAGVVGDATRSDVLLRAEVQRARQIIIATQRDDTAVLVTLTARQLNRGAKIVAAVREEENAPLLRQSGADAVITSASAAGRLLGLSVLSPSAGMVMEDLIQQGTGLDIVERPVIKAEVGLKVRETEDLVVSVVRGHRVLGYDDRAIGTLQLTDRLITIVRATPGTQAIPDTRRLPRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JNW4</accession>
    <name>A0A2M9JNW4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Aminoglycoside phosphotransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_27695</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000013">
        <property type="protein sequence ID" value="PJN08561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08561">
        <property type="protein sequence ID" value="PJN08561"/>
        <property type="gene ID" value="CG723_27695"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="APH" evidence="1">
        <location>
            <begin position="76"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN08561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="326" mass="36368" checksum="A450B8A26BF3F609" modified="2018-04-25" version="1">MVANEGVAVVGADVDDQGWSDTRAWVEKRVGGGCRIDAAERLRGGWTSEMRRLRIGGTGEPQWMVLRSFVKPFFVQHAKGLLTREAEILRLLSETDVPVAELRGVDATAVYCDHPSLLMSLLPGSVRLGEEEAGLRTQLLARQLVGIHQVRVPVEARPRVYQAWTSPDRVRLPESTERLDLWQRAVDIIRRDPPDYRPCFLHRDFHPGNVLFTGQGARLEITGVVDWVETSCGPADLDVAHCSTALALLHGAQEGMRLADLYLASGGTLSEDPAAHLYWRVLDALAFAPDAEKVAVPWRELGRDLTSDLLTSRLEEYLEELFRRFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JNX6</accession>
    <name>A0A2M9JNX6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Cation transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CG723_27820</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CB01635</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CorA metal ion transporter (MIT) (TC 1.A.35) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000013">
        <property type="protein sequence ID" value="PJN08578.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08578">
        <property type="protein sequence ID" value="PJN08578"/>
        <property type="gene ID" value="CG723_27820"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046873">
        <property type="term" value="F:metal ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045861">
        <property type="entry name" value="CorA_cytoplasmic_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045863">
        <property type="entry name" value="CorA_TM1_TM2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002523">
        <property type="entry name" value="MgTranspt_CorA/ZnTranspt_ZntB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01544">
        <property type="entry name" value="CorA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143865">
        <property type="entry name" value="SSF143865"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144083">
        <property type="entry name" value="SSF144083"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="251"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="284"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PJN08578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="317" mass="36144" checksum="C4F1640C05AD635C" modified="2018-04-25" version="1">MPEVTVTRTDMAEARERLAAARFLIVDVELPEEAPADGESVARQLGLEADDLDWFGRKDEPARVDFLGHKAGFVVPVIHDDQVAYIHALVTEQFLVTVHHGQAGLASNISAQLRHERPPDIVAVLFLLLQEALATFRRAAVHDLLLVEELEDDMFQERRPEQVYRLSMLRRRSALLHHSLLPYLQVVDEVFTRRMLNPSFPEERQRLAQEFSHAARLVLANIESLQDASRRAFSSYSSLAAGEQNGVINRLAIVSTIFLPLTFLSGFFGMNFTYLTDELESKVVFWLLAVGLQVAVLFVAFYVLHRTRIWRRLRDED</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JP41</accession>
    <name>A0A2M9JP41_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Pyridoxine/pyridoxamine 5'-phosphate oxidase</fullName>
            <ecNumber evidence="5">1.4.3.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">PNP/PMP oxidase</fullName>
            <shortName evidence="5">PNPOx</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">Pyridoxal 5'-phosphate synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5 11" type="primary">pdxH</name>
        <name evidence="11" type="ORF">CG723_26400</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CB01635</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the oxidation of either pyridoxine 5'-phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>H2O + O2 + pyridoxamine 5'-phosphate = H2O2 + NH4(+) + pyridoxal 5'-phosphate</text>
            <dbReference type="Rhea" id="RHEA:15817"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:58451"/>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
            <dbReference type="EC" id="1.4.3.5"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>O2 + pyridoxine 5'-phosphate = H2O2 + pyridoxal 5'-phosphate</text>
            <dbReference type="Rhea" id="RHEA:15149"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:58589"/>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
            <dbReference type="EC" id="1.4.3.5"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5 7">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
        <text evidence="5 7">Binds 1 FMN per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="5">Cofactor metabolism; pyridoxal 5'-phosphate salvage; pyridoxal 5'-phosphate from pyridoxamine 5'-phosphate: step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="5">Cofactor metabolism; pyridoxal 5'-phosphate salvage; pyridoxal 5'-phosphate from pyridoxine 5'-phosphate: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the pyridoxamine 5'-phosphate oxidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.4.3.5" evidence="5"/>
    <dbReference type="EMBL" id="NNBL01000012">
        <property type="protein sequence ID" value="PJN08634.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08634">
        <property type="protein sequence ID" value="PJN08634"/>
        <property type="gene ID" value="CG723_26400"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA01068">
        <property type="reaction ID" value="UER00304"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004733">
        <property type="term" value="F:pyridoxamine-phosphate oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008615">
        <property type="term" value="P:pyridoxine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01629">
        <property type="entry name" value="PdxH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000659">
        <property type="entry name" value="Pyridox_Oxase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019740">
        <property type="entry name" value="Pyridox_Oxase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011576">
        <property type="entry name" value="Pyridox_Oxase_put"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019576">
        <property type="entry name" value="Pyridoxamine_oxidase_dimer_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10851">
        <property type="entry name" value="PTHR10851"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10590">
        <property type="entry name" value="PNP_phzG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01243">
        <property type="entry name" value="Putative_PNPOx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000190">
        <property type="entry name" value="Pyd_amn-ph_oxd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00558">
        <property type="entry name" value="pdxH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01064">
        <property type="entry name" value="PYRIDOX_OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3 5 7" id="KW-0288">FMN</keyword>
    <keyword evidence="4 5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-0664">Pyridoxine biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Putative_PNPOx" evidence="9">
        <location>
            <begin position="69"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="domain" description="PNP_phzG_C" evidence="10">
        <location>
            <begin position="205"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="6">
        <location>
            <begin position="36"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="5 6">
        <location>
            <begin position="224"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5 7">
        <location>
            <begin position="93"/>
            <end position="98"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5 6">
        <location>
            <position position="98"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5 7">
        <location>
            <begin position="108"/>
            <end position="109"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5 7">
        <location>
            <position position="114"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5 7">
        <location>
            <position position="115"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5 7">
        <location>
            <position position="137"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5 6">
        <location>
            <position position="155"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5 6">
        <location>
            <position position="159"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5 6">
        <location>
            <position position="163"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5 7">
        <location>
            <begin position="172"/>
            <end position="173"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5 7">
        <location>
            <position position="218"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5 7">
        <location>
            <position position="228"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007301"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000190-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000190-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF10590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PJN08634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="246" mass="27914" checksum="2E18CAEDE1B646C7" modified="2018-04-25" version="1">MNSTRPTAPCVRQDDRVSDHHDHHDHHAPPNPAVMRAQYRLPGEGLLEEDVPARPMELFELWFNEATRARGVLYEPNAMVVSTADAAGRPSSRTVLLKAYDDRGFVFYTNYGSRKARDLAANHEIALLFPWHPMARQVIVSGTVAHTSREETAAYFRSRPRGSQLGAWASAQSQVLATRAELDAAYAELAERYPEGENIPVPDHWGGFRVTPRTVEFWQGRENRLHDRLRYVHEPSGAWRVERLGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JP67</accession>
    <name>A0A2M9JP67_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_27875</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000013">
        <property type="protein sequence ID" value="PJN08587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08587">
        <property type="protein sequence ID" value="PJN08587"/>
        <property type="gene ID" value="CG723_27875"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="154"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN08587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="179" mass="20049" checksum="299370B1E5752625" modified="2018-04-25" version="1">METLRLLVLACFDRAYRSSPTQRRPPPATRRYCPPLSANSPIWKLLWGHCPSIRGWARTPGTTTAVHLDLKARGPTDQIAERDAKTPIQAGGRWVVERTNSWMNNSGKLRPCTERRRAPIEFLIALAGAIITVRCLIRGAWPLYRWDTRPRSPPHPMTHAADADGQSVARPRGTEGLIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JP77</accession>
    <name>A0A2M9JP77_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_27955</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000013">
        <property type="protein sequence ID" value="PJN08597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08597">
        <property type="protein sequence ID" value="PJN08597"/>
        <property type="gene ID" value="CG723_27955"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097367">
        <property type="term" value="F:carbohydrate derivative binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901135">
        <property type="term" value="P:carbohydrate derivative metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05013">
        <property type="entry name" value="SIS_RpiR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000281">
        <property type="entry name" value="HTH_RpiR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035472">
        <property type="entry name" value="RpiR-like_SIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001347">
        <property type="entry name" value="SIS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046348">
        <property type="entry name" value="SIS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01418">
        <property type="entry name" value="HTH_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01380">
        <property type="entry name" value="SIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53697">
        <property type="entry name" value="SSF53697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51071">
        <property type="entry name" value="HTH_RPIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51464">
        <property type="entry name" value="SIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH rpiR-type" evidence="1">
        <location>
            <begin position="13"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="domain" description="SIS" evidence="2">
        <location>
            <begin position="136"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN08597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="301" mass="32476" checksum="82BA797E677F63F2" modified="2018-04-25" version="1">MSSAARQTPTNYNELVSRLQERSARLTPAQRLLAERVLADPEGVAFMTVSDLASAVGVNEATVVRFATGLGLSGYPGLTRLCRTHLREQAQLLRRYDNLEQLATEGGDLLERAAAQDLANISRTFAQVDRASWEEAVRALAEAPQVHVLGLRKCHAPAYLLGYLLRMLREDVVTVTGGAGGLADELRRVREGDCFVAVSVHRYAADTVRAFAWARRRGAHCVALTDNPSSPLAPEAHEAFFVDASSPSVLRSLTAFTSLVQALAAGVAQARGHDARSTLLREEELLEGLGVYVDGAGRDDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JPM4</accession>
    <name>A0A2M9JPM4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_27355</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000012">
        <property type="protein sequence ID" value="PJN08795.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08795">
        <property type="protein sequence ID" value="PJN08795"/>
        <property type="gene ID" value="CG723_27355"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025968">
        <property type="entry name" value="YwqJ_deaminase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14431">
        <property type="entry name" value="YwqJ-deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="121"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN08795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="190" mass="20102" checksum="D096BB84C2B02498" modified="2018-04-25" version="1">MQSSTAPSSDTAVAPAQEPDTGHPATADGTSGDPRVGWSSTDDAPAPALRQRRDGILPTVAAALSVRGTTLTSTAARGEHAPALHPLVQDFLDTLTSAQRDRFTGRCAETILISRHLTAADEERSKRARRKPMTNGEARKALKHAKLTTRRIREDGDPLHGGFARPCRACAALTAHFGVHVVDPATDTTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JPU9</accession>
    <name>A0A2M9JPU9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Serine protease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CG723_25720</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000011">
        <property type="protein sequence ID" value="PJN08894.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08894">
        <property type="protein sequence ID" value="PJN08894"/>
        <property type="gene ID" value="CG723_25720"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00190">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013517">
        <property type="entry name" value="FG-GAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028994">
        <property type="entry name" value="Integrin_alpha_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001314">
        <property type="entry name" value="Peptidase_S1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018114">
        <property type="entry name" value="TRYPSIN_HIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033116">
        <property type="entry name" value="TRYPSIN_SER"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13517">
        <property type="entry name" value="FG-GAP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00722">
        <property type="entry name" value="CHYMOTRYPSIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="SSF50494"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69318">
        <property type="entry name" value="SSF69318"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00134">
        <property type="entry name" value="TRYPSIN_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00135">
        <property type="entry name" value="TRYPSIN_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 6" id="KW-0645">Protease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0720">Serine protease</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Peptidase S1" evidence="5">
        <location>
            <begin position="60"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="26"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU363034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PJN08894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="560" mass="58300" checksum="EB99DA03F46B9362" modified="2018-04-25" version="1">MLPAAAAGLALIGGGAFAVTSYAGESDTGRVVQPPPGAKTAEPAASSPSPSGDKKVTPRIIGGTTSAASWMVQLVYNDPAGGSYFVCGGTLVAPNKVLTAAHCLHDENGNRQDWGKYGEVAVGTSKSVTVAGNGATYIDVTRSWVRDGYDPDAITNDVALLTLAKPVAQTTLELAGEGDGALYAAGTNATVYGWGLTSSNEDTADIASQLQKVTLPLNSDDACTQNLDPYFQAGKMICAGQLGTGDDSTGKTTCPGDSGGPLVVGDKVVGIVSWGISQGKQVCNVSGTYEAFTKVSTYQSKVRPRIDDTDISRNGKADLFVRAASGGKGYVKESTGSGFATRKTLTGSWSAYNLVLQADMNRDGYQDFIIRRRSDGAVYWRHRSASSSTYTDTKIASDWATRKFIVVPGDVTGDRFPDLLSATSGGTLYLYPGKGDGTYGTRTTVGSGYQVFNSLRGKGDFTGDGRSDLIARGSGGKLYLLKGTGKASAPFETGVQVRTWDGYNAFAAPGDVTGDGKADYVARTPGGTLYLYPGTGTASSEIFATRIKIGTGYTQYNVFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JQ98</accession>
    <name>A0A2M9JQ98_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CG723_24195</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000010">
        <property type="protein sequence ID" value="PJN09038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN09038">
        <property type="protein sequence ID" value="PJN09038"/>
        <property type="gene ID" value="CG723_24195"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014955084" evidence="3">
        <location>
            <begin position="32"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="116"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="148"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="214"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="239"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="267"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="300"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="54"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="361"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="393"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="424"/>
            <end position="448"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PJN09038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="448" mass="45379" checksum="32AC15BF3E065062" modified="2018-04-25" version="1">MPDNPRRLLKLTALVATAQTTGILLATRAFAAPDPKKDDPCGLIAGPARKYCERSDGGSGGGTPATPPGTTNPLDPLSSLARGCADAASWTVDMLSKSIKQTADVDFTNPKFLQQYAIVFAASAILTLLLWLLAVAKRAVRGVPLGTALSEAIGFLWLTVIASAFTPLILYTVVSATDGVSDVLAKATGDQTDAFFGTFSGALKKGDDIGGGPIMLIVVSLVSILAAGVLYLELYLRAVLLYVGALLGVVVYAGLVDKNLWGHVRRWAGVMIAVILVKPVIVIVLGLAGALSGSEGPDSLAAVVSGLAIVLLAIFASGMIYRFVPGFGDEIANGRNNRIMRGAENKAAAVISSPAALVSQGIKTHSARADGGGGSGGGQSRARPANPVSGGVAAHSTRPSSGGSGGGGGSVPSAAPPPRTSPTNTPHARNTRNGGNTGNSNRQGGAGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-05-25" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JQD8</accession>
    <name>A0A2M9JQD8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Sulfur reduction protein DsrE</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CG723_24425</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000010">
        <property type="protein sequence ID" value="PJN09076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN09076">
        <property type="protein sequence ID" value="PJN09076"/>
        <property type="gene ID" value="CG723_24425"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027396">
        <property type="entry name" value="DsrEFH-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003787">
        <property type="entry name" value="Sulphur_relay_DsrE/F-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02635">
        <property type="entry name" value="DrsE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75169">
        <property type="entry name" value="SSF75169"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PJN09076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="120" mass="12630" checksum="8DA0DB0A293C7069" modified="2018-04-25" version="1">MANKLVIKVTAGADAPERCSQAFTVAAVAVASGVEVSLWLTGESSWFALPGRAAEFELPHAAPLPDLIESILAAGRITLCTQCAARREITEKDVIEGVRIAGAQVFVQEAMTDGTQALVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JQE1</accession>
    <name>A0A2M9JQE1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CG723_24485</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000010">
        <property type="protein sequence ID" value="PJN09084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN09084">
        <property type="protein sequence ID" value="PJN09084"/>
        <property type="gene ID" value="CG723_24485"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PJN09084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="61" mass="6328" checksum="5EFBECAE5AB5BB75" modified="2018-04-25" version="1">MPFIAIAVAALAIGFEQLIQWKYGPMGIIAFVALSIGLKAKNNLISGIGAVILVMLLAQSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JQT9</accession>
    <name>A0A2M9JQT9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Sugar kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CG723_24930</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000010">
        <property type="protein sequence ID" value="PJN09157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN09157">
        <property type="protein sequence ID" value="PJN09157"/>
        <property type="gene ID" value="CG723_24930"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000600">
        <property type="entry name" value="ROK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18964">
        <property type="entry name" value="PTHR18964"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00480">
        <property type="entry name" value="ROK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PJN09157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="315" mass="32039" checksum="2C1C93EF68231712" modified="2018-04-25" version="1">MRHVIALDVGGTGMKAALVGADGTLLHQARRATGRERGPDAIVETILGFAADLRAYGEEHLGEPAAAAGVAVPGIVDDEHGIALYASNLGWRDVPMRRLLSERLEGIPVALGHDVRTGGLGEGRLGAGKGADRFLFVPLGTGIAGAIGIGGRIEPGAHGSAGEIGHIVVRPGGTDCSCGQRGCLERYASASAVSLAWAEATGDPEADAADCAKAVESGDPRARQVWLEAVDALADGLVTALTLLDPRTLIIGGGLAEAGETLFTPLRAAVEERVTFQKLPTIVPAALGDTAGCLGAGLLAWDLLAQSTDSTEVVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JR05</accession>
    <name>A0A2M9JR05_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Phosphoserine aminotransferase</fullName>
            <ecNumber evidence="6">2.6.1.52</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Phosphohydroxythreonine aminotransferase</fullName>
            <shortName evidence="6">PSAT</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">serC</name>
        <name evidence="8" type="ORF">CG723_25245</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CB01635</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the reversible conversion of 3-phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4-phosphonooxybutanoate to phosphohydroxythreonine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>2-oxoglutarate + 4-(phosphooxy)-L-threonine = (R)-3-hydroxy-2-oxo-4-phosphooxybutanoate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:16573"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58452"/>
            <dbReference type="ChEBI" id="CHEBI:58538"/>
            <dbReference type="EC" id="2.6.1.52"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 6">
            <text>2-oxoglutarate + O-phospho-L-serine = 3-phosphooxypyruvate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:14329"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:18110"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57524"/>
            <dbReference type="EC" id="2.6.1.52"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
        <text evidence="6">Binds 1 pyridoxal phosphate per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 6">Amino-acid biosynthesis; L-serine biosynthesis; L-serine from 3-phospho-D-glycerate: step 2/3.</text>
    </comment>
    <comment type="pathway">
        <text evidence="6">Cofactor biosynthesis; pyridoxine 5'-phosphate biosynthesis; pyridoxine 5'-phosphate from D-erythrose 4-phosphate: step 3/5.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 6">Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.52" evidence="6"/>
    <dbReference type="EMBL" id="NNBL01000010">
        <property type="protein sequence ID" value="PJN09217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN09217">
        <property type="protein sequence ID" value="PJN09217"/>
        <property type="gene ID" value="CG723_25245"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00135">
        <property type="reaction ID" value="UER00197"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00244">
        <property type="reaction ID" value="UER00311"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004648">
        <property type="term" value="F:O-phospho-L-serine:2-oxoglutarate aminotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006564">
        <property type="term" value="P:L-serine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008615">
        <property type="term" value="P:pyridoxine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00160">
        <property type="entry name" value="SerC_aminotrans_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000192">
        <property type="entry name" value="Aminotrans_V_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022278">
        <property type="entry name" value="Pser_aminoTfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006272">
        <property type="entry name" value="Pser_aminoTfrase_mycobac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00266">
        <property type="entry name" value="Aminotran_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000525">
        <property type="entry name" value="SerC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01366">
        <property type="entry name" value="serC_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="6" id="KW-0664">Pyridoxine biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6" id="KW-0718">Serine biosynthesis</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotran_5" evidence="7">
        <location>
            <begin position="19"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="region of interest" description="Pyridoxal phosphate binding" evidence="6">
        <location>
            <begin position="247"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="45"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="103"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="149"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="172"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="195"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="6">
        <location>
            <position position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001607"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PJN09217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="372" mass="39786" checksum="FD72B82B4EBED036" modified="2018-04-25" version="1">MAEIQIPADIKPADGRFGAGPSKVRTEALDALAATGTSLLGTSHRQAPVKNLVGRVREGVKDLFQLPEGYEVILGNGGSTAFWDVATHGLIENKSQHLNFGEFSSKFAKASKLAPWLAEPTVIASEPGTHPEPQAEAGVDVYGLTHNETSTGVAAPIKRVAGADEGALVLVDATSGAGGLPVDIAETDVYYFAPQKSFASDGGLWLAAFSPAALERAERIHASGRHIPEFFSLPTAIDNSRKNQTYNTPALATLFLLGEQLEWMNSQGGLAWTTARTKDSSTRLYSWAEDSKYATPFVTDAAKRSQVIGTIDFSDEIDAAAVAKVLRANGIVDTEPYRKLGRNQLRVAMFPAIDPADVEALTKCIDYVIEKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JSP3</accession>
    <name>A0A2M9JSP3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">RNA polymerase subunit sigma-70</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CG723_19410</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CB01635</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000006">
        <property type="protein sequence ID" value="PJN09911.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN09911">
        <property type="protein sequence ID" value="PJN09911"/>
        <property type="gene ID" value="CG723_19410"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050896">
        <property type="term" value="P:response to stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039425">
        <property type="entry name" value="RNA_pol_sigma-70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013249">
        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43133">
        <property type="entry name" value="PTHR43133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08281">
        <property type="entry name" value="Sigma70_r4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="6">
        <location>
            <begin position="27"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4_2" evidence="7">
        <location>
            <begin position="127"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="194"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF08281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PJN09911.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="228" mass="24388" checksum="D2C76ED3AC0EABDA" modified="2018-04-25" version="1">MLGDDAELTAAVHAAQDGDETAFRTVYRAVHPRLLGYVRTLVGEPDAEDVASEAWLQIARDLDRFSGDADRFRGWAARIARNRALDHIRMRGRRPAIGGDETELTGRPAVSDTADEAMELLATGDTLALIAQLPQDQAEAVVLRVVVGLDAKSAAQTLGKRPGAVRTAAHRGLKRLAELLGAEGSHVQTALAGRDGTLDAVPPPREPRGHAVTSAGVTHSRTRTQKDM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JT24</accession>
    <name>A0A2M9JT24_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_20170</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000006">
        <property type="protein sequence ID" value="PJN10035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN10035">
        <property type="protein sequence ID" value="PJN10035"/>
        <property type="gene ID" value="CG723_20170"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="75"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN10035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="198" mass="20506" checksum="02DF56F4F5762543" modified="2018-04-25" version="1">MSALSGALSFLALEMKSLGSSGGGGVVSANVGSAVAVSLGMSAVVGSWSAGLFEAEFLPLAETIANATAEPTATVASAPPPIISQRRRRARVSDASASAAQSGPCEPPLPPEPHWGPPCPKLMGRILDRRAGGAAARWGRGCAGSGRSCVCRVCASCVPGVTLVRRCLRRRAVYSGRRQGRPVRRIRRCRCPGPRFDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JTG0</accession>
    <name>A0A2M9JTG0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CG723_17330</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CB01635</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000005">
        <property type="protein sequence ID" value="PJN10170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN10170">
        <property type="protein sequence ID" value="PJN10170"/>
        <property type="gene ID" value="CG723_17330"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001958">
        <property type="entry name" value="Tet-R_TetA/multi-R_MdtG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006016">
        <property type="entry name" value="UspA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00582">
        <property type="entry name" value="Usp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01035">
        <property type="entry name" value="TCRTETA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="17"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="55"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="86"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="114"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="141"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="171"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="213"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="245"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="276"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="301"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="337"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="366"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="7">
        <location>
            <begin position="17"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="392"/>
            <end position="411"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PJN10170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="574" mass="58598" checksum="A72D6AD867CE625D" modified="2018-04-25" version="1">MSAPHGKAASPFKQPKAVWAVAFACVISFMGIGLVDPILPALAENLHASPSQVSLLFSSYLIVTAVAMLFVGWISSRIGAKRTLVVGLVVIVVFAALAGTAGSVNGIVGMRAGWGLGNAMFIATSLAVIVASASGGFGGAIILYEAALGLGIAVGPLLGGELGGISWRGPFFGVAVLMAIALVATLAFVPSLPKPKRPTSPIAPLKALRHRGLLTMGIMALLYNWGFFTMLGYAPYPMKLSAHELGLVFTGWGLLVAAFSVFFAPRLQARFGTAPVLYANLLGLGIVMALIAAGVDNPTVVIVAVIVSGAFIGINNTLTTQAVMLVSPVERPVASSAYGFLRFIGGGLAPFVAGKLADATDLSVPFYLGAATFLLAIPVLASGHGLLRKAEADPVESEPVSPSLTPVGKTAASADAPPVIVAVGAHDKAACIVDAAARLARDTGSPLEVVHVQQTAVVEEQAVDTETDEQARAAVTAHLDRLSADGIAATGQILTSVGDHAAAGRALAHHAADVHARAVAIGHSPRGPLAQFADGSLTTALTHSATCTVVLVDTDSTPRHLTKDSLAELRDSVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JTI8</accession>
    <name>A0A2M9JTI8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">AraC family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_17425</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000005">
        <property type="protein sequence ID" value="PJN10183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN10183">
        <property type="protein sequence ID" value="PJN10183"/>
        <property type="gene ID" value="CG723_17425"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018062">
        <property type="entry name" value="HTH_AraC-typ_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00041">
        <property type="entry name" value="HTH_ARAC_FAMILY_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="2">
        <location>
            <begin position="23"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN10183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="147" mass="16308" checksum="B80B4FAC06B54CFC" modified="2018-04-25" version="1">MCHPAWGRALAQDQRLKDLVRLRRVRDRIDRAYAQPLNVEALARGVDWPAGHLSRQFRLAYGLSPYAFLMTRRVERAKALLRGGDLTVTEVGFLVGYASQGVFRSRFTELAGVTPGAYRCGVVAAATRTPPIPVRNGEAFLTEPQLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JTL5</accession>
    <name>A0A2M9JTL5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Extradiol dioxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_17615</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000005">
        <property type="protein sequence ID" value="PJN10214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN10214">
        <property type="protein sequence ID" value="PJN10214"/>
        <property type="gene ID" value="CG723_17615"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VOC" evidence="1">
        <location>
            <begin position="3"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN10214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="114" mass="12314" checksum="35ADE495BC988169" modified="2018-04-25" version="1">MINGAHVIIYSHDAEADRAFFRDVLKYPHIDAGDGWLIFKLPPAEVAVHPAAAPSHELYLMCDDVDATVDELSAKGVECAPVTNAGWGLKTGIRLPGGGELGLYQPRHETAHNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-05-25" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JTU6</accession>
    <name>A0A2M9JTU6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">LacI family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CG723_18065</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000005">
        <property type="protein sequence ID" value="PJN10294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN10294">
        <property type="protein sequence ID" value="PJN10294"/>
        <property type="gene ID" value="CG723_18065"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01392">
        <property type="entry name" value="HTH_LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000843">
        <property type="entry name" value="HTH_LacI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046335">
        <property type="entry name" value="LacI/GalR-like_sensor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00356">
        <property type="entry name" value="LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13377">
        <property type="entry name" value="Peripla_BP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00036">
        <property type="entry name" value="HTHLACI"/>
    </dbReference>
    <dbReference type="SMART" id="SM00354">
        <property type="entry name" value="HTH_LACI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50932">
        <property type="entry name" value="HTH_LACI_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH lacI-type" evidence="4">
        <location>
            <begin position="6"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="domain" description="HTH cro/C1-type" evidence="5">
        <location>
            <begin position="7"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PJN10294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="346" mass="37034" checksum="4CE3E973DB0B7641" modified="2018-04-25" version="1">MNRQAPTLEDVAREAGVSRATVSRVINGVRNVDPGIQDQVRQAIDRTGYAPNRAARSLVTRRAETIALVVSGAGDEADSEQNAFAASVFADPFFGRIVSGVVGFLRPRSMHPVLMFAESDTARKQVTAYLRQGSADGALVVSTHAEDPLPELLAAERLPAVFFARPALTAPVSYVDLAHRDGGRLAAEHLLARGRRRVATVSGPLDVPAGQERLAGFRDGMERGGVPCVPVAEGGFTLDSGAAAMERLLGQHPDVDGVFAANDLMAQGVCQVLREQGRRVPEDVAVVGFDDSSVAVTCKPQLTTVRQPVEEMARAMARLLQEHIEGTRTEPTSLIFEPELVLRQSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JU17</accession>
    <name>A0A2M9JU17_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Spermidine/putrescine ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CG723_18510</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CB01635</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000005">
        <property type="protein sequence ID" value="PJN10364.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN10364">
        <property type="protein sequence ID" value="PJN10364"/>
        <property type="gene ID" value="CG723_18510"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="64"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="100"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="132"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="182"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="209"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="239"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="65"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PJN10364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="271" mass="28890" checksum="EC051BF04524C9A9" modified="2018-04-25" version="1">MNLSRPARITLRIAAALGFAVIYVPLLLVLVNSLNPDRSSGWPPPGLTFGWWADAWHSSGARDALWTSVKAGLGATAIALVLGTLIAFACQRYRFFGRDAISFVVVLPIALPGIVTGVALNTAFRTVLEPLGVGLGLFTVIVGHATFCIVVVFNNVIARLRRMPGSYEEAAMDLGAHSFRTYLDITFPLVRSALVAGGLLAFALSFDEIVVTTFTAGPAIQTLPVWIFSNMARPQQAPVVNVVAAVLVLLSVIPIYLAQRLSSDTASGSRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JUG7</accession>
    <name>A0A2M9JUG7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Thioredoxin reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_18830</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000005">
        <property type="protein sequence ID" value="PJN10513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN10513">
        <property type="protein sequence ID" value="PJN10513"/>
        <property type="gene ID" value="CG723_18830"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyr_redox_2" evidence="1">
        <location>
            <begin position="13"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN10513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="349" mass="36575" checksum="7C08DB99FE2BE1CE" modified="2018-04-25" version="1">MMSVHPSRDERRYDVVVIGGGAAGLSGALTLGRARRSVLVIDAGEPRNAPADGVHNYLGREGTPPGELVSTGRDEVRRYGGEIVAGRVVTAERDGDGFRVVLDDGGAVCAARILVTTGLADELPQVPGLAGLWGSDVLHCPYCHGWEVRDQAVGVLGTGPAAVHQALMWRQWSKSVTLFLHTAPEPTDEEYEQLAARGISVVDGTVAALENENGRLAGARLERGTLVPVQALVVAPRFTARAGFLGSLGLEPSEQEMNGMVIGTRIPAGPTGQTAVPGVWAAGNVTELTEQVIGSAAAGLRAAAAINADLMAEETRAAVEARRADFSGFSPEAERQVCERVLGSRRHGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-09-29" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JUS5</accession>
    <name>A0A2M9JUS5_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 8">Nicotinate phosphoribosyltransferase</fullName>
            <ecNumber evidence="4 8">6.3.4.21</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CG723_15325</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CB01635</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the first step in the biosynthesis of NAD from nicotinic acid, the ATP-dependent synthesis of beta-nicotinate D-ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>5-phospho-alpha-D-ribose 1-diphosphate + ATP + H2O + nicotinate = ADP + diphosphate + nicotinate beta-D-ribonucleotide + phosphate</text>
            <dbReference type="Rhea" id="RHEA:36163"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:32544"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57502"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.4.21"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 8">Cofactor biosynthesis; NAD(+) biosynthesis; nicotinate D-ribonucleotide from nicotinate: step 1/1.</text>
    </comment>
    <comment type="PTM">
        <text evidence="8">Transiently phosphorylated on a His residue during the reaction cycle. Phosphorylation strongly increases the affinity for substrates and increases the rate of nicotinate D-ribonucleotide production. Dephosphorylation regenerates the low-affinity form of the enzyme, leading to product release.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the NAPRTase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.21" evidence="4 8"/>
    <dbReference type="EMBL" id="NNBL01000004">
        <property type="protein sequence ID" value="PJN10588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN10588">
        <property type="protein sequence ID" value="PJN10588"/>
        <property type="gene ID" value="CG723_15325"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00253">
        <property type="reaction ID" value="UER00457"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004516">
        <property type="term" value="F:nicotinate phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004514">
        <property type="term" value="F:nicotinate-nucleotide diphosphorylase (carboxylating) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009435">
        <property type="term" value="P:NAD biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040727">
        <property type="entry name" value="NAPRTase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007229">
        <property type="entry name" value="Nic_PRibTrfase-Fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006405">
        <property type="entry name" value="Nic_PRibTrfase_pncB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036068">
        <property type="entry name" value="Nicotinate_pribotase-like_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11098">
        <property type="entry name" value="PTHR11098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17767">
        <property type="entry name" value="NAPRTase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000484">
        <property type="entry name" value="NAPRT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51690">
        <property type="entry name" value="SSF51690"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01513">
        <property type="entry name" value="NAPRTase_put"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="6 8" id="KW-0436">Ligase</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7 8" id="KW-0662">Pyridine nucleotide biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="NAPRTase_N" evidence="9">
        <location>
            <begin position="17"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004952"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU365100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF17767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PJN10588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="447" mass="47221" checksum="39C299ED1FFD6463" modified="2018-04-25" version="1">MNTADLGLPVDVPSTALFTDHYELTMLQAALKAGTADRRSVFEVFTRRLPDGRRYGVVAGTGRVLDAVENFRFDARELGFLRERGIIDEPTLERLAAYRFSGDIWGYPEGEVYFPGSPVLRVEGSFADCVLLETVILSILNHDSAIAAAASRMASAAAGRPLIEMGARRTHELAAVAASRAAYVGGFATTSDLAAGFRYGIPTVGTSAHAFTLLHDTERDAFRAQVDSLGEGTTLLVDTYDVTEAVRLAVEIAGPGLGAVRIDSGDLLLVAHRVRGQLDELGATETKIVVTSDLDEYAIASLAAAPVDAYGVGTQLVTGSGHPTCSMVYKLVARAESADPKAPLLPVAKKSMGAKTSVGGRKWAARRLDDQGAAEAEVIGTGPVPAELVDRQLLVELVKGGTVVAREPLDAARERHIEALGGLPLSATQLSRGEAVIPTEYLVDAPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JV74</accession>
    <name>A0A2M9JV74_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CG723_16405</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000004">
        <property type="protein sequence ID" value="PJN10764.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN10764">
        <property type="protein sequence ID" value="PJN10764"/>
        <property type="gene ID" value="CG723_16405"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PJN10764.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="224" mass="23599" checksum="753DFB04B92DB75E" modified="2018-04-25" version="1">MTAPVLHFADAGEGADLAAFLGRLVHYDRAAAVRLQAGGQALAVFGRPPSFEVLAIRTARLLKPYEYGLDSSLDVTVSAGELLESIDERAGSARVPAAVTGPPWAGVLPPRGGWELVPGFPDVDVVRGLVRAAVAEFKARVDELAPDARTRAELDRTGHEIWSRTIGDTGVPVRAAHAAQSLGFLRGDALDLLSSGSWLRLRTAYGSVALRRSNGISGLSVSPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JVS0</accession>
    <name>A0A2M9JVS0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_08285</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN10993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN10993">
        <property type="protein sequence ID" value="PJN10993"/>
        <property type="gene ID" value="CG723_08285"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017517">
        <property type="entry name" value="CHP03083_actinobac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034660">
        <property type="entry name" value="DinB/YfiT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010872">
        <property type="entry name" value="MDMPI_C-term_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024344">
        <property type="entry name" value="MDMPI_metal-binding"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07398">
        <property type="entry name" value="MDMPI_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11716">
        <property type="entry name" value="MDMPI_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109854">
        <property type="entry name" value="SSF109854"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03083">
        <property type="entry name" value="TIGR03083"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MDMPI_N" evidence="2">
        <location>
            <begin position="18"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="domain" description="MDMPI_C" evidence="1">
        <location>
            <begin position="151"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07398"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF11716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN10993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="248" mass="26171" checksum="7D4E325B58B3E39C" modified="2018-04-25" version="1">MTQTPAFEDLLALVQDRSAALRSSVAASPDLDVRVPSCPDWSLRDLVEHLTEVHRFWAAAVVAGPSEKPPTVPADDTLSADLLARSAAATQELIVALRAAGPAVDCWTWWSDSDVPTTSGAVARHQVQEAAVHAFDAQLATGTPQPVPTAVALDGIAEFIGVSHGTAGPWPHDPARIGLHAAEGESWLVDLSTSGSHLIDGPHETDADLHGSASNLLLALHGRRPLDSLRSEGDRATLENLLNWPDLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-05-25" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JWW4</accession>
    <name>A0A2M9JWW4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Rhamnose ABC transporter substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">rhaS</name>
        <name evidence="4" type="ORF">CG723_10680</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN11380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN11380">
        <property type="protein sequence ID" value="PJN11380"/>
        <property type="gene ID" value="CG723_10680"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015762">
        <property type="term" value="P:rhamnose transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013459">
        <property type="entry name" value="RhaS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025997">
        <property type="entry name" value="SBP_2_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13407">
        <property type="entry name" value="Peripla_BP_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02637">
        <property type="entry name" value="RhaS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014812521" evidence="2">
        <location>
            <begin position="27"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="domain" description="Peripla_BP_4" evidence="3">
        <location>
            <begin position="63"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="33"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PJN11380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="364" mass="38260" checksum="A4223DC4DCAC5F17" modified="2018-04-25" version="1">MSAPAPAPALRRACLALAAVTSLALAATACGGTTKDSAKDDDAGTSSHAKADPGAATKKGLKVAFLPKQVNNPYFTTADKGGEKAVTELGSTYKETGPNSATDTSGQVSYVNTLTQQQVDAMAVSAQDPGALCTALKQAMKNGIKVVTYDSDTKPECRNAFVSQASAEALGRTQVQLLGEQIGYKGDIAILSAAQTATNQNTWIDFMKDELKKPKYKDMKLVKVAYGNDDAQQSFQQTQGLLQEHPKLAGIISPTTVGIKAAAQYLSGSKYKGKVALTGLGTPNDMRKYVKNGTVEGFELWDPAKLGELAARTAVALSSGQITGKEGETFKAGGMGTFTIGKDGVIDLGKPTVFDRKNIDDYHF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JX25</accession>
    <name>A0A2M9JX25_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">YkuD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CG723_10915</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CB01635</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN11419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN11419">
        <property type="protein sequence ID" value="PJN11419"/>
        <property type="gene ID" value="CG723_10915"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd16913">
        <property type="entry name" value="YkuD_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.440.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005490">
        <property type="entry name" value="LD_TPept_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036365">
        <property type="entry name" value="PGBD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038063">
        <property type="entry name" value="Transpep_catalytic_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03734">
        <property type="entry name" value="YkuD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141523">
        <property type="entry name" value="SSF141523"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47090">
        <property type="entry name" value="SSF47090"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015000084" description="YkuD domain-containing protein" evidence="3">
        <location>
            <begin position="33"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="domain" description="YkuD" evidence="4">
        <location>
            <begin position="115"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF03734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PJN11419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="231" mass="24817" checksum="581088E492ED6041" modified="2018-04-25" version="1">MGDIRRRGAVALGITGLVAPLTLALGAAPAQAASCTTSTGPYQKQVEGFLGRPVDGKQSAADCKAVQAFQNKHGISPNIGYAGPVTWGVMDLMNKQKAVGSNPNKDGKCPVNKGRIACVNLTLQLSWIQDGKNLVYGPVPVRTGRNGYETRTGLKKIYWRHIDHVSSIYNVPMPYSQFFDGGQAFHSVGVSMWNPPGSHGCVNMTSTTAKKYWSLLKTGDDVYVYGRKPGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-09-29" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JX91</accession>
    <name>A0A2M9JX91_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CG723_11425</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CB01635</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN11505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN11505">
        <property type="protein sequence ID" value="PJN11505"/>
        <property type="gene ID" value="CG723_11425"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004638">
        <property type="entry name" value="EmrB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00711">
        <property type="entry name" value="efflux_EmrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="21"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="56"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="88"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="113"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="146"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="175"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="209"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="235"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="278"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="303"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="338"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="370"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="414"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="447"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="7">
        <location>
            <begin position="22"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="477"/>
            <end position="507"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PJN11505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="507" mass="51730" checksum="89FA4956A4989E4A" modified="2018-04-25" version="1">MTPEPVESTPGIRLSSARGRWILACVVLASGMAMLDGTVVNVALPTIGRDLDASLSSLQWVVNAYMLTLSALLLWGGALGDRIGRRRTLVLGVAWFAVASALCGLAPDQGVLIAARALQGVGGALLTPGSLALVRSSFHPDDQSRAVGAWSGLTGVAGALGPFLGGYLIDGPGWRWIFLINVPLAVIVLLIAVRHVPESREAGVAGTRFDMAGASLAALCLVGISYALIGSSGGASLVSTALPAVLGVAAGIAFVVVEHHRAEPMLPPSLFRSRLFSAANAMTLCLYAAIGGILFLLPVQLQIALGYSALQAGTATLPITVLMLLLSPRAGDLARRVGPTPPLVAGPLIAAVGLLLMLRIEPGASYVADVLPAVAVLGLGMSVFVAPLTATVLASVEPGRAGLASGVNNTAARIAQLLVVAALPLAVGLSGDAYTQPDSVNTSFHRAAMGCALLFALGSATAVVFIRPAAVRPRLEEAPKPQCRSHLGVAAPALEPGPHKRDQGKAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JXN5</accession>
    <name>A0A2M9JXN5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF4440 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_11590</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN11537.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN11537">
        <property type="protein sequence ID" value="PJN11537"/>
        <property type="gene ID" value="CG723_11590"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037401">
        <property type="entry name" value="SnoaL-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13577">
        <property type="entry name" value="SnoaL_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="SSF54427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SnoaL-like" evidence="1">
        <location>
            <begin position="6"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN11537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="155" mass="17815" checksum="16C3C313AD590554" modified="2018-04-25" version="1">MTDFQAIADRVEIEALRGEFTDAAMMRDRARLASLFTEDGVLRMPDVPIEMNGREEIRTGGERLQAQWDFFVQNTHPGVIRIDGDTATGRAYMQEIARMQSGFQGLNYAIYHDRYRRTDEGWRFTERVYEIRYFDTTPLTGSAPAGDIHAAQEAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-09-29" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JXR1</accession>
    <name>A0A2M9JXR1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CG723_12145</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CB01635</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN11628.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN11628">
        <property type="protein sequence ID" value="PJN11628"/>
        <property type="gene ID" value="CG723_12145"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="62"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="96"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="120"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="164"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="199"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="252"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="287"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="318"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="343"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="383"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="408"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="23"/>
            <end position="438"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PJN11628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="453" mass="47343" checksum="7AD4D6C10E3B0809" modified="2018-04-25" version="1">MSSNSTTPPTGRTVAGTADIKRLLSAAFIGTALEWYDYFLYGTAAALVFNKLFFPSLDATTATIASFVTFAVGFAARPIGAAVFGHIGDRYGRKAALIITVVMMGVATGCIGLLPSYDTIGIWAPVLLAVLRFVQGISVGGEWSGAMLLTLEHTPKEKHGSYSAVPQLGSPVGTLLSSGAFALVGLLPDDAFYAWGWRIPFLAAFGLLVFALYLRLRIEESPVFRAMIEDAEKSGPAPAPLIEAFRKTWGRMIISVLAAFLGIGGFFLLTTFMISYGTEQLGIAKSVMLNATLLAAVAEMVVIYIGGRIADRVGPWKVCAVGGVLSVLVAFPVFWLVDTGQTALVILGVTLGVAVISIPYATIGAVVTGLFPETFRYSAVAMSYNLSGVLGGFVPLLAAWLTGVTDGASWGVALLLVLIAACTAAGSFLAGPLLGSRSTTTPENTSAPQKATA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JXY4</accession>
    <name>A0A2M9JXY4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Amidohydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_12675</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN11712.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN11712">
        <property type="protein sequence ID" value="PJN11712"/>
        <property type="gene ID" value="CG723_12675"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01300">
        <property type="entry name" value="YtcJ_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013108">
        <property type="entry name" value="Amidohydro_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033932">
        <property type="entry name" value="YtcJ-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07969">
        <property type="entry name" value="Amidohydro_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="SSF51338"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydro_3" evidence="1">
        <location>
            <begin position="52"/>
            <end position="535"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN11712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="541" mass="57250" checksum="C447DD3E882868E7" modified="2018-04-25" version="1">MPSPLVLLSARLLDPVTGAFLPQTALAVSGGRISALGDDHGIREHVDASTTVIDLKGAVVTPGLVDGHLHPVSGAELTGGLDLSGCAGVEDVRALLAAEVRNLAPGAWLHGWGLDPNVFGDRPVGIAPFDSVLDGVPALLLLFDAHSMLASRRALELAGVDGPRTFDQASAEVVCDEQGRPTGLLQEDAACELVERVAPMPTREERRDRLAATLRAMAASGLTGGHVMDANGDSLALFSELDAAGELALRLRVAPWCQPGTDAEGVRALIEQQGAGGALWRTDGVKIFMDGTIDNGTAWLERPDCHGESTHAFWPDPDVYTRIIGELHRAGVPTATHAIGDAAVRHVLDAVEKAQATGGRGARHRVEHIETVPDDTLGRFAALGVIASMQPTHCCDFTRADHTDNWSRRLGEERASRAWRCRDLQDSGATVVLGSDWPIAPYPPLGVMAGARHRRPSRDLTQDPHGPEQALTPLEALHGLTVNAAYAAGEEREAGRIAVGFRADLTVLADNPLTTADTALPDLPVLLTVLDGRPTHRDASL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JYA5</accession>
    <name>A0A2M9JYA5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CG723_13485</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CB01635</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN11844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN11844">
        <property type="protein sequence ID" value="PJN11844"/>
        <property type="gene ID" value="CG723_13485"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045621">
        <property type="entry name" value="BPD_transp_1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19300">
        <property type="entry name" value="BPD_transp_1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="9"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="100"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="130"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="175"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="234"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="278"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="96"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PJN11844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="310" mass="32915" checksum="964133FBB0658BC4" modified="2018-04-25" version="1">MITYLARKLIALAVVLVVASFLVYGLLYLVPGGPMAFLLGNRSGTPEQIAAIRAQYRLDDPFLVRYAAWLGDAVRGDFGSSLVYRQHVSGLMGARAATTAFLVGYSTVLIVVVGVAGGVLAGLRRGRVDAVISAVSSAFLATPTFVIGVLLVIVFALGLGWFPVFGPGEGLFGRLYHLTLPAITLSLGSAAFLARITRASVREELGREHVETARSRGIAEALVIRRHVLRNASIPVITVTGLTVASLIAGSVVVENVFALDGLGSLFVRAILQRDFAVVQAVVLVLVAAFVLINLVVDLCYKALDPRMSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-09-29" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JYF7</accession>
    <name>A0A2M9JYF7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CG723_13760</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CB01635</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN11891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN11891">
        <property type="protein sequence ID" value="PJN11891"/>
        <property type="gene ID" value="CG723_13760"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="25"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="68"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="99"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="125"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="165"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="191"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="224"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="257"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="298"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="338"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="369"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="394"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="444"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="539"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="7">
        <location>
            <begin position="27"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="576"/>
            <end position="603"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PJN11891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="603" mass="63557" checksum="934F489792E0722E" modified="2018-04-25" version="1">MARTTAESAAARRGRFREPGPRYKWIALSNTTLGVLIATINMSIMLIALPDIFRGIGVDPLQPGNTSLLLWLIMSYMVVTAVLVVSFGRLGDMYGRVRMYNMGFAVFTVFSVLLSVTWMHGTAGALWLIGMRVLQGVGGAMLMANSNAILTDAFPARQRGLALGLNQVAGITGSFIGLVLGGLLGPVNWHLVFLVSVPFGLFGTVWAYLKLHDTGVRAGARLDWWGNLTFAVGLIAVLAGITYGIQPYGGAIMGWANPWVIAAIAGGVAVLVVFCVVETKVPEPMFHLSLFRIRAFTAGNVASLLAALGRGGLMFILIIWLQGIWLPRHGYGFEQTPLWAGIYMLPLTVGFLVAGPFSGWASDRFGARAFATGGMLLAAATFLALQALPVDFSYPMFALVLLLNGLGMGLFAAPNRAAIMNSLPPDQRGVGAGISTTFQNSATVLSIGIFFSLMIAGLSSALPAALNHGLTAQGVPAADAAKVAALPPVGVLFASLLGYNPIQTLLGPHVLAQLPPGHAHYLTGRGFFPELISQPFADGLSVAFGFAIAACVVAAIASLLRGGRYIYDDRTLPKPVTLPAPAPPPQTSTLPEAPPPTHRSEGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JYV1</accession>
    <name>A0A2M9JYV1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_14800</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN12063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN12063">
        <property type="protein sequence ID" value="PJN12063"/>
        <property type="gene ID" value="CG723_14800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014961464" evidence="2">
        <location>
            <begin position="24"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="56"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="82"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="122"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN12063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="153" mass="15660" checksum="0768E2D6BE69ED35" modified="2018-04-25" version="1">MTKLLLSLHVLAAVLAIGPVTVAASMFPRALRRIDADPSDHEAILTLRMLHRICRVYAAVGIAVPVFGFATAGSLGVLGSGWLIASILLTAAAAATLALLILPAQDNALAVAQTPGPGSRAAGRLAMLTGVFNLLWATVTVLMIIRPGSTTGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JZ46</accession>
    <name>A0A2M9JZ46_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">AraC family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CG723_10785</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN12141.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN12141">
        <property type="protein sequence ID" value="PJN12141"/>
        <property type="gene ID" value="CG723_10785"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032687">
        <property type="entry name" value="AraC-type_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12625">
        <property type="entry name" value="Arabinose_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="4">
        <location>
            <begin position="233"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PJN12141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="339" mass="35840" checksum="FB19215E8FD24238" modified="2018-04-25" version="1">MSVIRSAGLRGFRATVAELGGDADSYARQAGCPPAALDVDDLLVPEEAMATVLELAAADLGCADLGLRIAARQDLGMLGALALAIQNSDTLGDALECTSRYLFVHARSVNLSLEPDPYGTPGMAALRYGVREGVVAPPQGIDLSLGFIHRAIGYLVGPYGLGSVELPHPMLAPLSVYEDFFGVPVKGDRPAALLRVPLSLANRSLGGSNAQLRHLALAYLDEQLPKEPADVVGSVRAVVEQSLGTSSPEIGAVAGLLNVHPRTLQRRLRAAGTTFAEVIDEERRTAAHRYLTATDLPLGQVALLLGLSEQSALNRCCRRWWGATPRAIRLGVQGQPTDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JZ47</accession>
    <name>A0A2M9JZ47_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Histidine phosphatase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CG723_10520</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN12136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN12136">
        <property type="protein sequence ID" value="PJN12136"/>
        <property type="gene ID" value="CG723_10520"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00300">
        <property type="entry name" value="His_Phos_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="SSF53254"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PJN12136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="196" mass="20336" checksum="4324001A8ADAEB9D" modified="2018-04-25" version="1">MTSRVTLISAATSRSLREARFDDGCALDASAAARTRAAAGTLPAAERLLVSPTERCRETATALGLVAVEAPELAGLDVGRWRGLTLDEVSAEDPVGIALWLSDPGAAPHGGESVRALCARVARWLDSSAELDGRTLAVVEPEVVRAVAVTVLDAPGSAFWRLDVPPLTATDVSGRSGRWNIRLGRALGPSEDGAGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JZI3</accession>
    <name>A0A2M9JZI3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_04235</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000002">
        <property type="protein sequence ID" value="PJN12276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN12276">
        <property type="protein sequence ID" value="PJN12276"/>
        <property type="gene ID" value="CG723_04235"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="79"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN12276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="102" mass="11186" checksum="3E041B802319EACB" modified="2018-04-25" version="1">MRYRLTFVAGLALGYVLGTRAGRERYEQLKKSARGFAQNPAVRNTAESAAQQTRHFAGKAMHSVSVKVESRVPDSVAGRVRSLRERGQGGDGFEDDWGTSNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JZQ8</accession>
    <name>A0A2M9JZQ8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CG723_04800</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000002">
        <property type="protein sequence ID" value="PJN12373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN12373">
        <property type="protein sequence ID" value="PJN12373"/>
        <property type="gene ID" value="CG723_04800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SSF49879"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PJN12373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="131" mass="13955" checksum="2EF66E20435320D9" modified="2018-04-25" version="1">MLELTMASVAGADAGATAGMLMADAPSEPGAVLRVGRDRNVCRLATPDDWLFVSRVHLEFRCGQDGAWSVFWLRGSHDEPSSEVRLTLTGGEPRPLVYGGAAALAPGASGEVVVLDRNEPRSVNVGFYHEM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K065</accession>
    <name>A0A2M9K065_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_05660</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000002">
        <property type="protein sequence ID" value="PJN12519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN12519">
        <property type="protein sequence ID" value="PJN12519"/>
        <property type="gene ID" value="CG723_05660"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025445">
        <property type="entry name" value="DUF4191"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13829">
        <property type="entry name" value="DUF4191"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="32"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="59"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="210"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN12519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="233" mass="24758" checksum="444537DA626B9489" modified="2018-04-25" version="1">MARKETAADAANPGRLKQIALTFKMTRKADPMIALVLAAVGIVTFGVFLAIGFLIGHPVYLGILGFLLAFLAMAIVFGRRAERAAFGQMEGQPGAAAAVLDNIGRGWTTTPAVAMNRSQDVVHRAVGKAGIVLVAEGNPNRVKTLLAAEKRKMARIVSDVPVNDILVGNGEGQVPLKKLRTTMLKLPRVLTGPQVTTTNDRLRAMGDLMSNMPLPKGPMPKGMRMPRGGGKGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K087</accession>
    <name>A0A2M9K087_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CG723_05785</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CB01635</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000002">
        <property type="protein sequence ID" value="PJN12542.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN12542">
        <property type="protein sequence ID" value="PJN12542"/>
        <property type="gene ID" value="CG723_05785"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024320">
        <property type="entry name" value="LPG_synthase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031553">
        <property type="entry name" value="tRNA-synt_2_TM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09924">
        <property type="entry name" value="LPG_synthase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16995">
        <property type="entry name" value="tRNA-synt_2_TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="30"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="60"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="91"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="117"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="152"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="215"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="domain" description="tRNA-synt_2_TM" evidence="9">
        <location>
            <begin position="24"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="domain" description="LPG_synthase_C" evidence="8">
        <location>
            <begin position="254"/>
            <end position="560"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF09924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF16995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PJN12542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="599" mass="67138" checksum="C55142C6267F2320" modified="2018-04-25" version="1">MAADQTTSPPARRTHTSTPTTKRAAAFTVWYLRVVTFINFLSAVWVSLGQDLQRHNTNDYFTPYLLTAGFASGVFTWFLAITMRRRKRAAWILNLVLSGLFLLLFILVMFFPEVRRYAQNWISVVLTAAFVAALLLGRREFYAKGDRSNPKLAAVVGVGGLLVTSLFATFLVTVTNQAHDGHHSTFLERWRYGTLRLISVATDESRYPGITSPNWVNVVINILSTLLLLAVAYAAFRSRKAVDPITPDDEAKLRALLDKDGDRDSLGYFALRREKSVVWSPTGKAAVAYRVVGGVSLASGDPIGDPEAWPGAIDPWLMEAREHGWIPAVMGASEEAGTIYARHGLDALELGDEAIVEIGARGGAPDQGFTLEGRAMRTVRQAYNRVKRAGYEVRIRRHEDIPADEMTYLLQRADDWRDGATERGFSMALGRLGDPGDGRCVMLECTDGKGELKAVLSFVPWGPEGLSLDLMRRDRDSENGLMEFMVIELLQRAEEIGITQVSLNFAMFRSVFERGSRLGAGPVLRLWRSLLSFFSRWWQIESLYRANAKYRPIWEPRFLLFEKSADLPRIGLASARAEGFLEAPGLPNWMHRRHLEPHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K0E8</accession>
    <name>A0A2M9K0E8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_06155</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000002">
        <property type="protein sequence ID" value="PJN12611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN12611">
        <property type="protein sequence ID" value="PJN12611"/>
        <property type="gene ID" value="CG723_06155"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017501">
        <property type="entry name" value="Phage_infect_YhgE_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017500">
        <property type="entry name" value="Phage_infect_YhgE_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023908">
        <property type="entry name" value="xxxLxxG_rpt"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03062">
        <property type="entry name" value="pip_yhgE_Cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03061">
        <property type="entry name" value="pip_yhgE_Nterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03057">
        <property type="entry name" value="xxxLxxG_by_4"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="499"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="540"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="569"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="598"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="655"/>
            <end position="677"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN12611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="694" mass="73042" checksum="CD95B0F464842A56" modified="2018-04-25" version="1">MRSPKLAALELRRFGRGKLPRAALAALLLLPLLYGALYLWSFWDPYGRLDRIPVALVNDDKGARAAGQKVVAGDDITEGLHDSKTFEWHEVSAAQARKGVEDGTYYLSLTMPADFSERIASSSGDTPETGALQVRTNDANNYIVGQISRTVFSEVRSAASTNASRSFLDRIFISFSDIHDATKKAAKGADQLEGGIGKAKKGSKDLADGLKDAKKGSGELAGGIKKLNKGAGDLESGSKQVSDGTQLLADKVNGVAGQVRPFLKDNKKAIGDTARLVADSAKGIRHNLDVLVKTAPTAAKGAHAGSDVLDGVYQARCETLPLPDPACPDLKKAKVAAADVAKVADDLNVLIEDDHGDLDTLDRHLATLQRQSEALAEHAPTLDQDVATAVSKINALNKGAGQVAKGAKQLHTGLGTAKTGSADLDTGVGKLKTGASDLNGGMFKLADGSGELAGGLHDGVKQIPDYDKKDRDQRTGVMSDPVQLASQSLHKAPNYGTGFAPYFIPLSLWVGAMVAYMLIQPLNRRALAAGASAWRIALAGWLPVAALGVLQVAALMSVLHWALGLQMVRAAGTVGFLFLVTACFAAIVQWLNARFGAAGRILVLAVLMLQLTSAGGTYPVQTSPGFFNAIHPFLPMTYVVEALRRLISGGGLGPVWQACAVLAAFTAGALALTALSARSKQVWTLDRLHPELSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K0M6</accession>
    <name>A0A2M9K0M6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Glutamate synthase</fullName>
            <ecNumber evidence="7">1.4.1.13</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">gltD</name>
        <name evidence="7" type="ORF">CG723_06545</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CB01635</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="4">Amino-acid biosynthesis.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.4.1.13" evidence="7"/>
    <dbReference type="EMBL" id="NNBL01000002">
        <property type="protein sequence ID" value="PJN12678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN12678">
        <property type="protein sequence ID" value="PJN12678"/>
        <property type="gene ID" value="CG723_06545"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00189"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004355">
        <property type="term" value="F:glutamate synthase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006537">
        <property type="term" value="P:glutamate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1060.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028261">
        <property type="entry name" value="DPD_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006005">
        <property type="entry name" value="Glut_synth_ssu1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009051">
        <property type="entry name" value="Helical_ferredxn"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14691">
        <property type="entry name" value="Fer4_20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01317">
        <property type="entry name" value="GOGAT_sm_gam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="3" id="KW-0314">Glutamate biosynthesis</keyword>
    <keyword evidence="2 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fer4_20" evidence="6">
        <location>
            <begin position="40"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="domain" description="Pyr_redox_2" evidence="5">
        <location>
            <begin position="146"/>
            <end position="456"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00029440"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF14691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PJN12678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="486" mass="52602" checksum="2D53AA4E69FE2B51" modified="2018-04-25" version="1">MADPKGFLNHGREVAKTRPVGERVRDWNEVYVPGSLLPIISKQAGRCMDCGIPFCHNGCPLGNLIPEWNDYAYREDWSAAQERLHATNNFPEFTGRLCPAPCESACVLGINQPAVTIKNVEVSIIDQAWDRGDVAPQAPERLSGKTVAVIGSGPAGLAAAQQLTRAGHTVAVYERADRIGGLLRYGIPEFKMEKRHINRRIEQMRAEGTKFRTGVEIGRDIDAAKLRKRYDAVVIAAGATTARDLPVPGRELKGVYQAMEYLPLANKVQEGDYVTTPVSAEGKHVVVIGGGDTGADCVGTAHRQGAASVTQLEIMPRPGEDRNAGQPWPTFPMLYKVTSAHEEGGERVYSVSTTHFEGDEDGNVQFLHLAEVEFIDGKLTPKPGTERKIPAQLVTLAMGFTGTDQDNGLVSQFALDLDARGNVARDDEFQTNVPGVFVAGDAGRGQSLIVWAIAEGRSAARGVDRFLTGVSELPAPIRPTDRSLTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-05-25" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K163</accession>
    <name>A0A2M9K163_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Ectoine dioxygenase</fullName>
            <ecNumber evidence="6">1.14.11.55</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Ectoine hydroxylase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">thpD</name>
        <name evidence="11" type="ORF">CG723_07635</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CB01635</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Involved in the biosynthesis of 5-hydroxyectoine, called compatible solute, which helps organisms to survive extreme osmotic stress by acting as a highly soluble organic osmolyte. Catalyzes the 2-oxoglutarate-dependent selective hydroxylation of L-ectoine to yield (4S,5S)-5-hydroxyectoine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>2-oxoglutarate + L-ectoine + O2 = 5-hydroxyectoine + CO2 + succinate</text>
            <dbReference type="Rhea" id="RHEA:45740"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:58515"/>
            <dbReference type="ChEBI" id="CHEBI:85413"/>
            <dbReference type="EC" id="1.14.11.55"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the PhyH family. EctD subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.11.55" evidence="6"/>
    <dbReference type="EMBL" id="NNBL01000002">
        <property type="protein sequence ID" value="PJN12875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN12875">
        <property type="protein sequence ID" value="PJN12875"/>
        <property type="gene ID" value="CG723_07635"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016706">
        <property type="term" value="F:2-oxoglutarate-dependent dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012774">
        <property type="entry name" value="EctD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008775">
        <property type="entry name" value="Phytyl_CoA_dOase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05721">
        <property type="entry name" value="PhyH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02408">
        <property type="entry name" value="ectoine_ThpD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00021894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00031142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PJN12875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="297" mass="32778" checksum="DD78F120221639C5" modified="2018-04-25" version="1">MSTETRTDLYPTRGASEVATPRVDPVVWSPPDARGPIRQSDLAGFERDGFLAIEELIGPDEIGTYQAELNRLITDPAVKADERSIVEPTSQDVRSVFEVHRISEVFANLVHDERVVGRARQILGSDVYVHQSRINVKPGFGASGFYWHSDFETWHAEDGLPNMRTVSVSIALTENYDTNGGLMIMPGSHRTFLGCAGETPRDNYKKSLQMQDAGTPSDEALTKFADRHGIRLFTGSAGSATWFDCNAMHGSGDNITPYPRSNVFIVFNSVENTAVEPFAAPVRRPAFIGARDFTPVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-05-25" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K1C0</accession>
    <name>A0A2M9K1C0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">IMP dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_07885</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000002">
        <property type="protein sequence ID" value="PJN12916.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN12916">
        <property type="protein sequence ID" value="PJN12916"/>
        <property type="gene ID" value="CG723_07885"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ADH_N" evidence="2">
        <location>
            <begin position="26"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="domain" description="ADH_zinc_N" evidence="1">
        <location>
            <begin position="180"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN12916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="347" mass="36185" checksum="2471DD8E0117E32E" modified="2018-04-25" version="1">MRATTIHAPFDMRVEDVPEPVVQLPTDAVVRVLRACICGSDLWAYRGEAARQPGQRIGHEFLGIVEDTGSEVTGVRRGDLVVAPFMWSDGVCDYCTEGLTTSCEHGGFWGAVGYDGGQGEAVRVPYADGTLVQLPADAASDDHLLTALLTLSDVMGTGHHAALGAGARAGATVAVVGDGAVGLCAVLAAKRLGAERIIALGRHQVRTDIARRFGATDVVAERGDAAIEAVRELTRGQGAHAVIEAVGTEQSMSTAVNITRDGGAIGFVGVPHGSGTGLDLSVMFDRNIALRGGVAPVRTYIPQLLPDILDGKIDPSPVFDLTVGLEGVPDGYKAMDQRTALKVLVTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K1P7</accession>
    <name>A0A2M9K1P7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Amino acid ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CG723_00180</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CB01635</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000001">
        <property type="protein sequence ID" value="PJN13062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN13062">
        <property type="protein sequence ID" value="PJN13062"/>
        <property type="gene ID" value="CG723_00180"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006865">
        <property type="term" value="P:amino acid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010065">
        <property type="entry name" value="AA_ABC_transptr_permease_3TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043429">
        <property type="entry name" value="ArtM/GltK/GlnP/TcyL/YhdX-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30614">
        <property type="entry name" value="PTHR30614"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01726">
        <property type="entry name" value="HEQRo_perm_3TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="73"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="112"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="141"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="216"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="244"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="7">
        <location>
            <begin position="67"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PJN13062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="295" mass="31787" checksum="E07BC9EE765E06F2" modified="2018-04-25" version="1">MSSSVLYDAPGPKARVRNRIYTVVGSLAVLGLIAFTLYRMNVKGQLEPEVWNIFNNAGVRTSIRDGVLTTLKVFAVAGVLSLVLGLLLAVARLSEHKTVRWAATGFIELFRAIPLLITIYALWFLFLTYKTSLGVVGDNTAFWALVIGLTVYNGCVQAEVIRAGVNAVPRGQVEAAYALGLRKSQVMTMLLLPQAVRSMLPTMISQLVVTLKDTSLGYIITYSELLFAARTMASNIIVNGENPITAVVIVVGAIYVALCLALAALATWIERRGRRARTGIAVATATNPSVVNGTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K1S1</accession>
    <name>A0A2M9K1S1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_00225</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000001">
        <property type="protein sequence ID" value="PJN13069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN13069">
        <property type="protein sequence ID" value="PJN13069"/>
        <property type="gene ID" value="CG723_00225"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028037">
        <property type="entry name" value="Antitoxin_Rv0909/MT0933"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14013">
        <property type="entry name" value="MT0933_antitox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="40"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN13069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="87" mass="8874" checksum="5FD3BA932CF6932B" modified="2018-04-25" version="1">MGIMDTLKAKLSKDKASDLAQQHGDKIDQGLDKAGKTADQKTQGKYSDQIQTGTSKAKDAMDRFGGPGQDKGGSSGGGATPPPPPAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K1V9</accession>
    <name>A0A2M9K1V9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cysteine dioxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_00170</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cysteine dioxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000001">
        <property type="protein sequence ID" value="PJN13060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN13060">
        <property type="protein sequence ID" value="PJN13060"/>
        <property type="gene ID" value="CG723_00170"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016702">
        <property type="term" value="F:oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010300">
        <property type="entry name" value="CDO_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12918">
        <property type="entry name" value="PTHR12918"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05995">
        <property type="entry name" value="CDO_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="2">
        <location>
            <position position="70"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="72"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="129"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR610300-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN13060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="175" mass="19203" checksum="906799F975269F02" modified="2018-04-25" version="1">MSASPSPSLATAAPTQRDLLDFVRRTAEDHELIASLPLDPEGRTWVRLEGPGGSEAWLIGWPPGTGTGWHDHAESVGAFLTASGELKENSLAARLPADGWKTLELSEDVDRERTLAAGKGRAFGQHHVHEVLNESTSEHAISVHAYYPPLPQIRRYSRAGAVLRLETVERPEDWQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K221</accession>
    <name>A0A2M9K221_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MerR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_00795</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000001">
        <property type="protein sequence ID" value="PJN13165.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN13165">
        <property type="protein sequence ID" value="PJN13165"/>
        <property type="gene ID" value="CG723_00795"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000551">
        <property type="entry name" value="MerR-type_HTH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13411">
        <property type="entry name" value="MerR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00422">
        <property type="entry name" value="HTH_MERR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="SSF46955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50937">
        <property type="entry name" value="HTH_MERR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH merR-type" evidence="1">
        <location>
            <begin position="17"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN13165.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="113" mass="12425" checksum="67B85DA4BFC4BD60" modified="2018-04-25" version="1">MTAEGPLGRLDDDDYPAFTMGRAAEMIGTTPAFLRAIGEARLITPLRSAGGHRRYSRYQLRIAARARELVDRGTPVEAACRIIILEDQLEEALRINEEFRRAAAGPEAGAEGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K290</accession>
    <name>A0A2M9K290_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ribonuclease D</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_01185</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000001">
        <property type="protein sequence ID" value="PJN13233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN13233">
        <property type="protein sequence ID" value="PJN13233"/>
        <property type="gene ID" value="CG723_01185"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008408">
        <property type="term" value="F:3'-5' exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.80">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002562">
        <property type="entry name" value="3'-5'_exonuclease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041605">
        <property type="entry name" value="Exo_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010997">
        <property type="entry name" value="HRDC-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002121">
        <property type="entry name" value="HRDC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044876">
        <property type="entry name" value="HRDC_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01612">
        <property type="entry name" value="DNA_pol_A_exo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18305">
        <property type="entry name" value="DNA_pol_A_exoN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00570">
        <property type="entry name" value="HRDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00474">
        <property type="entry name" value="35EXOc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00341">
        <property type="entry name" value="HRDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47819">
        <property type="entry name" value="SSF47819"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50967">
        <property type="entry name" value="HRDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HRDC" evidence="2">
        <location>
            <begin position="247"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="224"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN13233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="427" mass="45859" checksum="16378DCB7DF70EB8" modified="2018-04-25" version="1">MTDAQETAADTSLRTTGGAPPDDGGSVAEVPIPLLEPREGIPPVIADEASLAEVVAAFAAGTGPVAVDAERASGYRYGQRAYLVQLRREGAGSALIDPVACPDLSALGDAIADAEWVLHAATQDLPCLREIGMVPSRLFDTELAGRLAGFPRVGLGAMVENVLGYVLEKGHSAVDWSTRPLPDPWLRYAALDVELLVDLRDALEKELDRQGKLDWAHQEFDAIASAPPAPPRKDPWRRTSGMHKVRRRRQMAVVRELWTARDRIAQRRDVSPGKVLGDGAIVEAALSLPPNVHALAALPGFGHRTGRRQLEQWQAAVDRAKELPDAELPQPGAPLAGPPPPRAWADKDPVAAARLSAARASVSSLAETLNMPQENLVTPDTVRRVCWEPPGDRSEAAVAEALRGYGARPWQIEQVTPLLAEALKQTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K2C1</accession>
    <name>A0A2M9K2C1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">N-acetylmuramoyl-L-alanine amidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_01360</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000001">
        <property type="protein sequence ID" value="PJN13263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN13263">
        <property type="protein sequence ID" value="PJN13263"/>
        <property type="gene ID" value="CG723_01360"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008745">
        <property type="term" value="F:N-acetylmuramoyl-L-alanine amidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009253">
        <property type="term" value="P:peptidoglycan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06583">
        <property type="entry name" value="PGRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.80.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036505">
        <property type="entry name" value="Amidase/PGRP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002502">
        <property type="entry name" value="Amidase_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01510">
        <property type="entry name" value="Amidase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00644">
        <property type="entry name" value="Ami_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55846">
        <property type="entry name" value="SSF55846"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetylmuramoyl-L-alanine amidase" evidence="2">
        <location>
            <begin position="27"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="195"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="276"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00644"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN13263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="297" mass="32485" checksum="2E08E446CEAC2D45" modified="2018-04-25" version="1">MATPLSASKLVEILRKEGLTVHEVRSWRTHNRNTKGPWGPVNGVMIHHTVTSGTDASVNICYNGYSGLPGPLCHGVIDKKGEIHLVGNGRANHAGLGDSDVLRAVVNESKLPHDNEADTDGNRHFYGFECINLGDGKDPWPEAQKEAIEKVSAAICRHYGWSERSVIGHKEWQPGKQDPRGFTMDSMRKRIADRLAGKSQGSDPKPDPKPTPSKPSHAPFPGSGFFHNGQKSAVITAMGRRLVAEGCDHYEEGPSPEWTDADRKSYKAWQQKLGFKGKDADGIPGKTSWDKLKVPAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K2J4</accession>
    <name>A0A2M9K2J4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Peroxiredoxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CG723_01835</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000001">
        <property type="protein sequence ID" value="PJN13346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN13346">
        <property type="protein sequence ID" value="PJN13346"/>
        <property type="gene ID" value="CG723_01835"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004601">
        <property type="term" value="F:peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000866">
        <property type="entry name" value="AhpC/TSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024706">
        <property type="entry name" value="Peroxiredoxin_AhpC-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00578">
        <property type="entry name" value="AhpC-TSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000239">
        <property type="entry name" value="AHPC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="1" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="5">
        <location>
            <begin position="5"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="active site" description="Cysteine sulfenic acid (-SOH) intermediate" evidence="3">
        <location>
            <position position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000239-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PJN13346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="155" mass="16697" checksum="A75EB180498434C2" modified="2018-04-25" version="1">MSKRVEAGDTVEDFTLPDESGTPTRLSELLSEGPVVLFFYPAAMTPGCTAEACHFRDLAAEFAAVGARPVGVSADPVERQAEFAGKHTLGFPLLSDADGEVRERFGVARGFSIAPTKRATFVLGPDRVVLEVVRSEFRMSAHADRALAMLRERAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K2T3</accession>
    <name>A0A2M9K2T3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Sugar kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_02415</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000001">
        <property type="protein sequence ID" value="PJN13444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN13444">
        <property type="protein sequence ID" value="PJN13444"/>
        <property type="gene ID" value="CG723_02415"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="28"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN13444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="192" mass="21361" checksum="B32C3120DF7151A5" modified="2018-04-25" version="1">MTVPRQPSSPDEGQRPPGNRRRVIRRRALTLLTIVLLIGVPAGYLVISANQSRNSGKDKEAKYSATGLTIGWPSKVQRRLYQVPIPVSSAKGVAYYETNNLRTSRLYVRFRTTDSGLDKFLKTIGTSSSKLQKDEVPISPRNQKVVGWAFDGPGPYRGLTHKQKNPEPTLDIVVNRENPAKPFVYVVSTTTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K331</accession>
    <name>A0A2M9K331_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CG723_02960</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000001">
        <property type="protein sequence ID" value="PJN13536.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN13536">
        <property type="protein sequence ID" value="PJN13536"/>
        <property type="gene ID" value="CG723_02960"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PJN13536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="154" mass="17482" checksum="19E3A099BE484C04" modified="2018-04-25" version="1">MSTAHDFDFFFGDWDVAHRRRTDFLDADSGWEEFAATNRCWSLFDGAANIDEMDCPTEGFKGLTLRLFDRAAGTWSLNWSSSRTGVLFPPVIGRFDGDGRGVFEGDDTHDGKDVRVRFVWSGISATTAHWEQFFSLDGGDTWLSNWTMAFTRRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K381</accession>
    <name>A0A2M9K381_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_03220</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000001">
        <property type="protein sequence ID" value="PJN13584.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN13584">
        <property type="protein sequence ID" value="PJN13584"/>
        <property type="gene ID" value="CG723_03220"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014786660" evidence="1">
        <location>
            <begin position="26"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN13584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="171" mass="18978" checksum="765E9ECCD0E4B596" modified="2018-04-25" version="1">MRRPALAGFMVVLMAALGACGGGGADNVSGHGGGKGGGYSKPHSDQVRGLYDAVRHLPRKTAKGTRAHMVKECDPATRKVKHTSRSGSGKRKKIRTWYTTEHYKQCHKVRKGSETYTRVVRTERWCVRLDDVNGKAAKDDLWFRVSPATYSEVHGKDEHARVKFEPRARGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K3B0</accession>
    <name>A0A2M9K3B0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Peptidase S15</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_02840</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000001">
        <property type="protein sequence ID" value="PJN13517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN13517">
        <property type="protein sequence ID" value="PJN13517"/>
        <property type="gene ID" value="CG723_02840"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008239">
        <property type="term" value="F:dipeptidyl-peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005674">
        <property type="entry name" value="CocE/Ser_esterase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000383">
        <property type="entry name" value="Xaa-Pro-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013736">
        <property type="entry name" value="Xaa-Pro_dipept_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02129">
        <property type="entry name" value="Peptidase_S15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08530">
        <property type="entry name" value="PepX_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00939">
        <property type="entry name" value="PepX_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="SSF49785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00976">
        <property type="entry name" value="NonD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014844889" evidence="1">
        <location>
            <begin position="30"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="domain" description="PepX_C" evidence="2">
        <location>
            <begin position="368"/>
            <end position="594"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN13517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="600" mass="63468" checksum="A6602B89BC1D321A" modified="2018-04-25" version="1">MEVAVPRSRPRSPLALALGAVVAAPLALAAPANATPPTQQTGEYTVTALKFTVQAGGRSCVVDADLYRPAGVDAAHTAPAVLATNGFGGSKSDGSTDAIGKAFAARGYVGLVYSGLGFGKSGCLVSLDDPRIDGAAASGLVDFLAGTRAADDGTKADYVTEDGKGDPRVGMIGGSYGGAIQLATAAVDHRVDALVPMITWNDLAYSLDPNNAADRSVPGSFKWQWTNGFYLIGEGQPLLEPSLDPSRINKLTCLHFVTDACETISTLNSGRYPSDKTGPMLDYARSVSPVSYLKRVKAPTLLVQGQSDSLFNLNEAQATYGTLKAQGTTTKMIWQSWGHSGGLTDPASGELNLAQGNLETSYVGKRILAWFDRYLQHKKDVDTGPAFAYYRDWITDPDQTYATAQSVPSPSRKLYLSGDGKLVDNRAKVARGSREYANWLIPTSHSESSLAGLIGLPDPAPRDTAGTYLGWTSEPLTSTTDVVGSPKATLKVVSPKTERVQNSDDAADKLVLFAKLYDIAPDGSKTLVHRLVAPVRVPDVTRSFTVSLPGIVHRYETGHRLQFVIAASDDAYSGNKGIKPVTVTSAPEDTGVLELPVVGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K3C9</accession>
    <name>A0A2M9K3C9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">3-carboxy-cis,cis-muconate cycloisomerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">pcaB</name>
        <name evidence="3" type="ORF">CG723_03440</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000001">
        <property type="protein sequence ID" value="PJN13619.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN13619">
        <property type="protein sequence ID" value="PJN13619"/>
        <property type="gene ID" value="CG723_03440"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047472">
        <property type="term" value="F:3-carboxy-cis,cis-muconate cycloisomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016840">
        <property type="term" value="F:carbon-nitrogen lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019619">
        <property type="term" value="P:3,4-dihydroxybenzoate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.275.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019468">
        <property type="entry name" value="AdenyloSucc_lyase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024083">
        <property type="entry name" value="Fumarase/histidase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020557">
        <property type="entry name" value="Fumarate_lyase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000362">
        <property type="entry name" value="Fumarate_lyase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022761">
        <property type="entry name" value="Fumarate_lyase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008948">
        <property type="entry name" value="L-Aspartase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012789">
        <property type="entry name" value="Protocat_PcaB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10397">
        <property type="entry name" value="ADSL_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00206">
        <property type="entry name" value="Lyase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00149">
        <property type="entry name" value="FUMRATELYASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00998">
        <property type="entry name" value="ADSL_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48557">
        <property type="entry name" value="SSF48557"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02426">
        <property type="entry name" value="protocat_pcaB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00163">
        <property type="entry name" value="FUMARATE_LYASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ADSL_C" evidence="2">
        <location>
            <begin position="366"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN13619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="444" mass="45747" checksum="1D1DBFBD6A083DED" modified="2018-04-25" version="1">MTHVDPDAGLLAPGRAGSPAESATSDAAVLRALLDAEAGLTRAQAALGLAPVAAADAVTRAATDERRFDPRDLALRARSGGNPVIPLVADLTAAVAGEHAPYVHRGATSQDILDSALMLVAARTLDGLLGDLTRTESALGRLASAHRDTVMPGRTLTQHAVPTTFGLKAAGWRSLVLDARDRLNTVRAALPVQLGGAAGTLAAFGVFGATNAGELTEAYAAELGLVAPVLPWHTLRTPVADLAGALAFTAGALAKPAADVLTLSRTEIGELSEGAGGGSSAMPHKANPVRATLVAAAARRAPALAATLYASMAAEDERPAGAWHAEWEPLRDLLRLVGGAARDAAELAEGLQVHAHVMRENLLATHGLIVSERLAAELAPLLGRARAKSLLTEAARRTRAEDRPLAEILADEPDLKGVDLADLTDPARYTGSAGALTDRALERR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K3D7</accession>
    <name>A0A2M9K3D7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Acyl-ACP desaturase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CG723_03525</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CB01635</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
        <text evidence="7">Binds 2 iron ions per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the fatty acid desaturase type 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000001">
        <property type="protein sequence ID" value="PJN13632.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN13632">
        <property type="protein sequence ID" value="PJN13632"/>
        <property type="gene ID" value="CG723_03525"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045300">
        <property type="term" value="F:acyl-[acyl-carrier-protein] desaturase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01050">
        <property type="entry name" value="Acyl_ACP_Desat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.620.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005067">
        <property type="entry name" value="Fatty_acid_desaturase-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009078">
        <property type="entry name" value="Ferritin-like_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012348">
        <property type="entry name" value="RNR-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31155">
        <property type="entry name" value="PTHR31155"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03405">
        <property type="entry name" value="FA_desaturase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000346">
        <property type="entry name" value="Dlt9_acylACP_des"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47240">
        <property type="entry name" value="SSF47240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="4" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="7" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="7">
        <location>
            <position position="88"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="119"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="122"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="172"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="202"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="205"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000346-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PJN13632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="325" mass="36582" checksum="9E05A1AA75228580" modified="2018-04-25" version="1">MTITSPHLGSSSSTWTDAQLLYALEEVVEKELNRHLKVAKDWMPHEYVPWADARNFPGFFEDGEAWAKDQSKVTEIGRIALVVNLLTEDNLPSYHHEIASLFGRDGAWGTWVHRWTAEEGRHGIVMRDYLLASRAVDPDQLEQFRMAHMAEGFESDNRHSMLHSVAYVAFQELATRVSHRNTGHQSGDPVCDRMLARIATDENLHMVFYRNLLGAAFELAPDLTMQAVRDVVVNFRMPGHGMPGFERAAAQMAIGEIYNMRIHHDDVIQPVLRYLKVLDIDGLGPEGLKAQEELGLYMGGLDSEASKFDEKLAARKARMAARAAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-09-29" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K3M4</accession>
    <name>A0A2M9K3M4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="10">DEAD/DEAH box helicase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CG723_00780</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000001">
        <property type="protein sequence ID" value="PJN13731.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN13731">
        <property type="protein sequence ID" value="PJN13731"/>
        <property type="gene ID" value="CG723_00780"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 10" id="KW-0347">Helicase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Q_MOTIF" evidence="9">
        <location>
            <begin position="39"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="7">
        <location>
            <begin position="70"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="8">
        <location>
            <begin position="264"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="428"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="5">
        <location>
            <begin position="39"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="440"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="471"/>
            <end position="487"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PJN13731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="487" mass="51961" checksum="2D002908EFFFA605" modified="2018-04-25" version="1">MKRMYGAGRESRAGRTGRSVVSGEFALPKTVRPGLPAVASFGELALPDELLRMLASLGMNEPFPIQAATLPNSLAGRDVLGRGRTGSGKTLAFGLALLARTAGRRAEPRSPLALVLVPTRELAQQVTEALTPYARSLKLRTATVVGGMSIGRQAGALRGGVEIVVATPGRLKDLIDRGDCRLDEVAVTVLDEADQMADMGFMPQVTALLDQVRREGQRMLFSATLDRNVDLLVRRYLHDPVVHSVDPSAGAVTTMEHHVLHVHPVDKHAATTEIAARDGRVIMFLDTKHAVDRLTRDLLAVGVRAAALHGGKSQPQRTRTLAQFKSGHVTVLVATNVAARGIHVDSLDLVVNVDPPADHKDYLHRGGRTARAGESGSVVTLVMPNQRRDMSRLMRDAGITPQIAQVRSGEAELSRITGARAPSGVPVVITAPVAERPRRSGSSTRGRRSRSAEARRAAGPWRAADQPRTGQGSGAFRQSASPVATAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K3W8</accession>
    <name>A0A2M9K3W8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CG723_00710</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000001">
        <property type="protein sequence ID" value="PJN13727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN13727">
        <property type="protein sequence ID" value="PJN13727"/>
        <property type="gene ID" value="CG723_00710"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PJN13727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="79" mass="8008" checksum="98EBAEA5F93FBBE0" modified="2018-04-25" version="1">MVTGPSKPRTPKVQEALDARDALAGALSRAGVQLPAMDVRTPWAGDGEGESRYALVHLGVCSAPVALQLAAVIAKGVGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JF97</accession>
    <name>A0A2M9JF97_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NmrA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_43975</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000045">
        <property type="protein sequence ID" value="PJN05566.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN05566">
        <property type="protein sequence ID" value="PJN05566"/>
        <property type="gene ID" value="CG723_43975"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008030">
        <property type="entry name" value="NmrA-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05368">
        <property type="entry name" value="NmrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NmrA" evidence="1">
        <location>
            <begin position="9"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN05566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="304" mass="33225" checksum="FD5DA6E676570E1C" modified="2018-04-25" version="1">MRNTDTPRVLVLGATGRTGAAVVKALEMTPGQAVPVRASRSETTVEQWIKEGKEAVRIDLDDPDTFTSALEGIDRVFLMTGYTSAMNHQTKTLVDAAEDAGVTFLVHLGVFSDKRSTDPHFAWHELVERYIAGSKLTWANVHPHVFMENLLGINRLRDGQMVWPMGDKQVGWIANDDIAAVVAKVLAEGPETHAGKDYYLSADLLNGSEVAEALSAALGRDIPALVLTPDDLQRMIDAGLNTAPANMDAAYAASTLIWARQTYEGRFDYSAVTTSTVQDLLGREPIHLEAWATAHRQELLDQIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JFD2</accession>
    <name>A0A2M9JFD2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MarR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_43655</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000044">
        <property type="protein sequence ID" value="PJN05600.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN05600">
        <property type="protein sequence ID" value="PJN05600"/>
        <property type="gene ID" value="CG723_43655"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000835">
        <property type="entry name" value="HTH_MarR-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12802">
        <property type="entry name" value="MarR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00598">
        <property type="entry name" value="HTHMARR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00347">
        <property type="entry name" value="HTH_MARR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50995">
        <property type="entry name" value="HTH_MARR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH marR-type" evidence="1">
        <location>
            <begin position="23"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN05600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="161" mass="17344" checksum="4385DAD392ED8803" modified="2018-04-25" version="1">MAADDPHQATASRATDRPGDESPFALGLLLRRAHWRAAAVMGEALRPLGIELRHFAVLIALVNRGPTVQRDLATATGSDKAGIMRVVDDLERMGLAVRKTVPGDRRVRAVEITPQGVELFDAAHVAAEPLAEHLVAELGPGESAQLRDLLTRFAYPADDEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JFP2</accession>
    <name>A0A2M9JFP2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Glycerol-3-phosphate dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CG723_43015</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CB01635</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000042">
        <property type="protein sequence ID" value="PJN05704.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN05704">
        <property type="protein sequence ID" value="PJN05704"/>
        <property type="gene ID" value="CG723_43015"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009331">
        <property type="term" value="C:glycerol-3-phosphate dehydrogenase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004368">
        <property type="term" value="F:glycerol-3-phosphate dehydrogenase (quinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006072">
        <property type="term" value="P:glycerol-3-phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.870">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031656">
        <property type="entry name" value="DAO_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038299">
        <property type="entry name" value="DAO_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000447">
        <property type="entry name" value="G3P_DH_FAD-dep"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11985">
        <property type="entry name" value="PTHR11985"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16901">
        <property type="entry name" value="DAO_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01001">
        <property type="entry name" value="FADG3PDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DAO" evidence="6">
        <location>
            <begin position="40"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="domain" description="DAO_C" evidence="7">
        <location>
            <begin position="426"/>
            <end position="538"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF16901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PJN05704.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="540" mass="58211" checksum="E06ACC9EAB81CD98" modified="2018-04-25" version="1">MTTLQSVPALGTHPAVGSTASFKAASRAETREQLSKAQYDLLVIGGGILGISTAWHAAQSGLRVALVDAGDFAGATSSASSKLLHGGLRYLQTGAVKLVAENHFERRAVSRQVAPHLANPLTFYLPVYKGGPHGAAKLGAGVFAYSALSAFGDGVGHLLSPAKAQQDVPELRTENLKAVAVYGDDQMNDARMALMTVRAAVDSGAVVLNHAEVTGLRFTRGRVTGADLKDRVDGEEFGVNARLVLNATGPWVDHLRAMEDPNAAPSIRLSKGAHLVLKRTSPWKAALATPIDKYRITFALPWEDMLLLGTTDEEYEGDPRDVSVTEKDTDQILDEAAFSVRDQQLKRDLITYSFAGLRVLPGGPGDTSKAKRETVVTEGRGGMLSVAGGKWTTFRHIGRTVMKKLESLPGHPLGEDFEPVKELPKRMPLPGVANPRAVAHRLLVDNPAPGPRMAADTAKHLATHYGSLAFDIARMANENPELGRRVHPDAPEIWAQVAYARDHEWAETADDVLRRRTTLTIRGLATDDVRAKVQDVLDKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JFX5</accession>
    <name>A0A2M9JFX5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Iron ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CG723_42970</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CB01635</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000041">
        <property type="protein sequence ID" value="PJN05796.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN05796">
        <property type="protein sequence ID" value="PJN05796"/>
        <property type="gene ID" value="CG723_42970"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037294">
        <property type="entry name" value="ABC_BtuC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000522">
        <property type="entry name" value="ABC_transptr_permease_BtuC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30472">
        <property type="entry name" value="PTHR30472"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01032">
        <property type="entry name" value="FecCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81345">
        <property type="entry name" value="SSF81345"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="21"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="75"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="107"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="134"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="164"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="211"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="251"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="290"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="323"/>
            <end position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PJN05796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="347" mass="35817" checksum="BA2BB80B7726DA91" modified="2018-04-25" version="1">MLVDSPPEQRADTAAAPPNRWAIRTVGLLGAVVVLLVLLVVSIAIGAKPLSVDQVWHGLFDDTGTFSDVVVGERLARTLLGLLAGVALGLSGAVLQALTRNPLADPGLLGINMGASAAVVTAISFFGVSSLTGYVWFAFLGAAAVGVLVYVLGGTRSATPVRLALAGTAISAALYGYLQAVMIMDNAALGKMRFWTVGSLVSADMSTIRQVLPFITVGTVLALALARPLNAMAMGDDTARALGANLNRTRALSMAAATLLCGAATAACGPIVFVGLMVPHVVRSFTGPDLRWILPFSAVLSPVLLLGADVVGRLVARPAEIQVGIVTAIIGGPVFIYLVRRRKVTQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JG17</accession>
    <name>A0A2M9JG17_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Amidophosphoribosyltransferase</fullName>
            <shortName evidence="5">ATase</shortName>
            <ecNumber evidence="5">2.4.2.14</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Glutamine phosphoribosylpyrophosphate amidotransferase</fullName>
            <shortName evidence="5">GPATase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">purF</name>
        <name evidence="11" type="ORF">CG723_42530</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CB01635</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5 6">
            <text>5-phospho-beta-D-ribosylamine + diphosphate + L-glutamate = 5-phospho-alpha-D-ribose 1-diphosphate + H2O + L-glutamine</text>
            <dbReference type="Rhea" id="RHEA:14905"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:58681"/>
            <dbReference type="EC" id="2.4.2.14"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5 8">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="5 8">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5 9">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="5 9">Binds 1 [4Fe-4S] cluster per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 5 6">Purine metabolism; IMP biosynthesis via de novo pathway; N(1)-(5-phospho-D-ribosyl)glycinamide from 5-phospho-alpha-D-ribose 1-diphosphate: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 5 6">In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.14" evidence="5"/>
    <dbReference type="EMBL" id="NNBL01000040">
        <property type="protein sequence ID" value="PJN05818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN05818">
        <property type="protein sequence ID" value="PJN05818"/>
        <property type="gene ID" value="CG723_42530"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00124"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004044">
        <property type="term" value="F:amidophosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009113">
        <property type="term" value="P:purine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00715">
        <property type="entry name" value="GPATase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01931">
        <property type="entry name" value="PurF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017932">
        <property type="entry name" value="GATase_2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRibTrfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005854">
        <property type="entry name" value="PurF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035584">
        <property type="entry name" value="PurF_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00156">
        <property type="entry name" value="Pribosyltran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000485">
        <property type="entry name" value="Amd_phspho_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="SSF53271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="SSF56235"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01134">
        <property type="entry name" value="purF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51278">
        <property type="entry name" value="GATASE_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="5" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="5 6 11" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="5 9" id="KW-0408">Iron</keyword>
    <keyword evidence="5 9" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="5 8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 5 6" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glutamine amidotransferase type-2" evidence="10">
        <location>
            <begin position="23"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="5 7">
        <location>
            <position position="23"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5 9">
        <location>
            <position position="268"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5 8">
        <location>
            <position position="315"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5 8">
        <location>
            <position position="377"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5 8">
        <location>
            <position position="378"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5 9">
        <location>
            <position position="414"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5 9">
        <location>
            <position position="465"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5 9">
        <location>
            <position position="468"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR000485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000485-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000485-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000485-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PJN05818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="508" mass="54363" checksum="F17A2800B036E4F7" modified="2018-04-25" version="1">MPRGDGRLNHDLLPGEKGPQDACGVFGVWAPGEEVAKLTYFGLYALQHRGQESAGIAVSNGSQILVFKDMGLVSQVFDETSLSSLQGHIAVGHARYSTTGASVWENAQPTFRATAHGSIALGHNGNLVNTAQLAEMVAALPKENGRNTQLAATNDTDLVTALLAGQVDDDGKPLTIEDAAAKILPEVQGAFSLVFMDEHTLYAARDPQGIRPLVLGRLERGWVVASESAALDICGASYVREIEPGEFVAIDENGLRTSRFAEAKPKGCVFEYVYLARPDTDIAGRNVYLSRVEMGRKLAKEAPVEADLVIATPESGTPAAIGYAEASGIPFGAGLVKNAYVGRTFIQPSQTIRQLGIRLKLNPLKEVIKGKRLVVVDDSIVRGNTQRALVRMLREAGAAEIHIRISSPPVKWPCFFGIDFATRAELIANGMSIDEIGKSLGADSLSYISIDGMIEATTIDKPNLCRACFDGEYPMDLPDPELLGKQLLETELAAGPANTAATDALRRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JGI2</accession>
    <name>A0A2M9JGI2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Peptide ABC transporter substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_41810</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000037">
        <property type="protein sequence ID" value="PJN05986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN05986">
        <property type="protein sequence ID" value="PJN05986"/>
        <property type="gene ID" value="CG723_41810"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042597">
        <property type="term" value="C:periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030678">
        <property type="entry name" value="Peptide/Ni-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039424">
        <property type="entry name" value="SBP_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000914">
        <property type="entry name" value="SBP_5_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30290">
        <property type="entry name" value="PTHR30290"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00496">
        <property type="entry name" value="SBP_bac_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002741">
        <property type="entry name" value="MppA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014889847" evidence="1">
        <location>
            <begin position="30"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="domain" description="SBP_bac_5" evidence="2">
        <location>
            <begin position="103"/>
            <end position="526"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN05986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="625" mass="68424" checksum="EC7169C706DEEB0A" modified="2018-04-25" version="1">MRSFRSTAAAVLVLAAALTGCTHEGGSIAMGPTGGTPVEGGTATMALPPAATPNWIFPIGAPGYGASYNYAIQTLLFMPVYDAVQLKGGLTTHGPSTLGLEPKYSDGNKTVTVPLREGVKWSDGKPVTSRDLEFWFNLVKADKADWGSYSVGTMPDNVKRFEVVDDHTVRLHLDRAYNPDWFTANQLTLMRALPQHAWDATTDGGRVGDHDRTTKGAKAVFARLTRHAKSLGSYGSDPLWTTVNGPWKLAGWRDSGQVTIVPNEKFTGPDSERPHLDKVVFKPFTTADSEYNVLRSGGVDYGYIPPSVMAQKAKFEDKGYRVDPWEGWAATYIVYNFNSTHAGPLMSQLYIRQAMQHLVDQKAMSDVIWQGSATPTLGPVPVTPKSQYLSPAMAKNRYPFSVRTARELLSAHGWKTRDGIARCARPGTGDDECGAGVKENAPLEMTLLSQSGSTETTNMMQELKSSLSRAGIDLTVRQQPLNSVLGNSVPCTAKAPGCDWDMSFFGTAGSWYYPLNPSGEQLFSTGASANFGNYSDRKADRIIRAVQYSPDMKAVHEYGEYLAGQLPVMWMPNPAYQVSVIRNDLRGIEQNPTVTFAPQHWYFVKNDKQHTNDTNNQHAKKGAAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JGN2</accession>
    <name>A0A2M9JGN2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">TetR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_41345</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000036">
        <property type="protein sequence ID" value="PJN06049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN06049">
        <property type="protein sequence ID" value="PJN06049"/>
        <property type="gene ID" value="CG723_41345"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023772">
        <property type="entry name" value="DNA-bd_HTH_TetR-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01081">
        <property type="entry name" value="HTH_TETR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="16"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="39"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN06049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="212" mass="22852" checksum="7BED946390E1C078" modified="2018-04-25" version="1">MTTPSSKAGTKGVPRADREQQVLAAATEEFGHHGYEATTVAAVAARVGVTKPLVHQYFGSKQDLYLACLEPVGDRLLGAVRAAMAEHETGAPPTPLRVLNALFTALNGQRETWFVLYDPSLPPGSNAAHRAAYYRDAIDDLAAIGTADLVHAAETRDPLDADALKHAWRGLCTALVRWWIKHPDQSPEAMSQRCTRLFEAGHTILAAGDDST</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JGR2</accession>
    <name>A0A2M9JGR2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CG723_41475</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000036">
        <property type="protein sequence ID" value="PJN06068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN06068">
        <property type="protein sequence ID" value="PJN06068"/>
        <property type="gene ID" value="CG723_41475"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PJN06068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="237" mass="26451" checksum="9CF058359A9E6C62" modified="2018-04-25" version="1">MCFDQAKPHPRARVGFHAERQDTSTAGWRHLLELIDEAAEDGREEFRPLVELSAEERRQVVTLPTSIAKLTAVKHFVLYGSNLVRIPPEIGAMTSLEEFTPYTSYRLHWFPYEITRCSKLVRSTVSTRALFGNYKLRPPFPRLQPPQFSAADLDLSALDARRWGTTAIRGCSVCDRPIGQGGLHQVWISLRVATDVLPLLVNACSAACVSALPSGAEDYVQLPHTGGRVKQPPSDWD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JGS2</accession>
    <name>A0A2M9JGS2_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">GHL10 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CG723_41530</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000036">
        <property type="protein sequence ID" value="PJN06075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN06075">
        <property type="protein sequence ID" value="PJN06075"/>
        <property type="gene ID" value="CG723_41530"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003790">
        <property type="entry name" value="GHL10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02638">
        <property type="entry name" value="GHL10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014773735" description="GHL10 domain-containing protein" evidence="2">
        <location>
            <begin position="29"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="domain" description="GHL10" evidence="3">
        <location>
            <begin position="53"/>
            <end position="365"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PJN06075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="424" mass="47390" checksum="78DBD5475F44D741" modified="2018-04-25" version="1">MERLSRRTFAAAAAGTLAAVTLPANAQAADTPAAGAGTEHAPVAGGHGAGHRQLRGMWIATVANTDWPSAPGLSPEEQRQELCDLLDVAVERRLNAVMFQVRPTADALWPSPYEPWSQYLTGVQGRDPGWDPLGTAVHEAHRRGLELHAWFNPYRVSLATDVSALTPTHPARLHPEWIVPFGGKLYYNPGLPEVRRFVEDAMLDAVRRYPIDAVHWDDYFYPYPVAGQTFQDDDAYARYGTGFPDRDAWRRNNTDLLVREMAERIKRIRPRTRFGISPFGVWRNAGTDPLGSATTAGVQTYDDLHADTRKWVQEEWIDYIVPQVYWNIGFAAADYGVLVPWWSNVVSGTRVRLYIGEALYKVGVAGQPAAWQDQAELSRHLDFDTHYPQVRGNVYFSATQVAADPLGAMSRVVADHYPTRVRTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JGV0</accession>
    <name>A0A2M9JGV0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Type I-E CRISPR-associated protein Cas7/Cse4/CasC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">cas7e</name>
        <name evidence="1" type="ORF">CG723_40825</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000035">
        <property type="protein sequence ID" value="PJN06095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN06095">
        <property type="protein sequence ID" value="PJN06095"/>
        <property type="gene ID" value="CG723_40825"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010148">
        <property type="entry name" value="CRISPR-assoc_prot_CT1975"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09344">
        <property type="entry name" value="Cas_CT1975"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01869">
        <property type="entry name" value="casC_Cse4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PJN06095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="387" mass="42239" checksum="2A25A80EB5140097" modified="2018-04-25" version="1">MPARYLDLHVTEMLPASCLNRGEHDLPKTFQLGNTTRAVITSQSFKRAIRTALEEELNEYAVRTRRIPPRVIAALKRAGWPDDLADYAGSQIAQCSTPSGLASDETKSHRTQALIYTAEKALLDDLTDVCIRHRTALQEGLAATRTPAPKGKKNEPARCLPAKELGAILARRTACITLFGRMLAGHDDSHVSGAVHMAWAFTTHTSDRQPDFFTTKEDWDEPGDRGSAFLDTAFLTAGVFYRYACVNLTELTANLDGDTDEALRLTGLFMDTFLLTHPGAKQTSTAPHTLPDTAAYVVRDRRPVSYAAAFDQPVRASHQGGYLASTRRALSQQAALTDRLIGARRRIGHGHTTAHTSPLDHLGPHHDGFEDLTAAALLAAAQPPARS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JH36</accession>
    <name>A0A2M9JH36_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_40520</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000034">
        <property type="protein sequence ID" value="PJN06163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN06163">
        <property type="protein sequence ID" value="PJN06163"/>
        <property type="gene ID" value="CG723_40520"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="74"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN06163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="92" mass="10343" checksum="23F1EDE58359189C" modified="2018-04-25" version="1">MVAPAPVPTPGKTAGTYDDPECLDQQQQRRNRGSRGGRPTGFDGERYKKRNTVERAINRLKGFRAVATRYEKRAYIYLSTVTLAALLIWLGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-05-25" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JHH0</accession>
    <name>A0A2M9JHH0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">N-methyltryptophan oxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_39960</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000032">
        <property type="protein sequence ID" value="PJN06320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN06320">
        <property type="protein sequence ID" value="PJN06320"/>
        <property type="gene ID" value="CG723_39960"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045170">
        <property type="entry name" value="MTOX"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10961">
        <property type="entry name" value="PTHR10961"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DAO" evidence="2">
        <location>
            <begin position="19"/>
            <end position="375"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN06320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="394" mass="41549" checksum="9DB8A3813B9E9AEF" modified="2018-04-25" version="1">MTGPDADIAHTADTADSADVAVVGLGAWGASALWQLARRGIRAVGIERYGLANINGSSHGESRMFRTACLEHPALVPLAQRSRALWRQLENETGTRLFEPTGAMLIGPEDGRIVGGALRAAREHGLDIEVLDRDALRRRCPAHEGLPQGHIGVVEPAGGLTLPEATIRAAVGAARAAGARVLTDTRVTALEFTGTDVAVHTAAGRVLRVGQVVVCAGPWLDQLVPGLPLEVVRMPTTWFTPEVPDERFTLGRLPVFMRELDGGDVLWGHGTLPGGTEVKLGLEDGGKHFRVVDPETVDRSVAPADWSVLAGHLATTVPGVGPDPSRVTANLYARTPDGQFVIGRPRGNPGLVVAGGCSSHGFKHSTGIGEVVADLVQGKEPAFPLGFTDPDRFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JHR2</accession>
    <name>A0A2M9JHR2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Beta-galactosidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CG723_39150</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CB01635</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000030">
        <property type="protein sequence ID" value="PJN06426.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN06426">
        <property type="protein sequence ID" value="PJN06426"/>
        <property type="gene ID" value="CG723_39150"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016052">
        <property type="term" value="P:carbohydrate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036156">
        <property type="entry name" value="Beta-gal/glucu_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006103">
        <property type="entry name" value="Glyco_hydro_2_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006102">
        <property type="entry name" value="Glyco_hydro_2_Ig-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006104">
        <property type="entry name" value="Glyco_hydro_2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00703">
        <property type="entry name" value="Glyco_hydro_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02836">
        <property type="entry name" value="Glyco_hydro_2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02837">
        <property type="entry name" value="Glyco_hydro_2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49303">
        <property type="entry name" value="SSF49303"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="SSF49785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glyco_hydro_2_N" evidence="7">
        <location>
            <begin position="35"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_hydro_2" evidence="5">
        <location>
            <begin position="196"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_hydro_2_C" evidence="6">
        <location>
            <begin position="300"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PJN06426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="622" mass="69538" checksum="DB0F33DA45EB8B02" modified="2018-04-25" version="1">MSTLSEERPHPDPQNAGVPRPEYPRPSFVRDEWLNLNGTWQFAFDPGDSGLERGLVDAELPGTITVPFCPESELSGIGDTDFHAAVWYRRTVRIPEGWQGRRPVLHFGAVDHDATVWVNGREVARHSGGFTSFSADLAGVARAGEDAVIVVRARDTRQGPQARGKQSDRYDNYTCLYTRATGIWQTVWLEPVADTHLGRPRITPDLAAGCFHLELPLSGNRKGHHIRARLTDEQGTVAEGSVAAHLDLAPRLVLAVPEERRRCWSPEDPHLYEIHLEVVDGDAAVVDSARCTAGLRSVTIEGKQVLLNGHPVFQRLVLDQGWYPDGLMTAPSDAALVRDIKLSLAAGFNGARLHQKVFEERFLHHADRLGYLVWAEFGDWGAGTGASSGDTHQQTIGFAAQWLEAVERDHSHPSIIGWCPLNETRQELHDRRTTLDDATRALFLATKAADTSRPVLDTSGYSHRVPETDIYDSHCYEQDPDAFRQLMAGLDKNEPFINPQDEPGDTEWSVAYRGQPYFCSEFGGIWWNPDEAAPDDGSRNSSWGYGERPRDEEEFHQRFAGLTGVLLDDPDMFGYCYTQLTDVFQEENGIYRFDRSVKLDVTRVRAAQQRPAACESAAERMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JHV1</accession>
    <name>A0A2M9JHV1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_38635</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000029">
        <property type="protein sequence ID" value="PJN06466.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN06466">
        <property type="protein sequence ID" value="PJN06466"/>
        <property type="gene ID" value="CG723_38635"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="130"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="165"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="43"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN06466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="202" mass="20038" checksum="9B453A152487BFE9" modified="2018-04-25" version="1">MVTKTDDETAETAEATTAEATEAASETPEVIEVTKEAEATDAVEAAEGTDGDADADLDDEPFAPAAPVEDSSGAGQGAGAVVSAALGVVALSGSWVATVASARESLIGQLQTSQGASVAKQVSEVYGDSWHATALVGGIFALLALIVGAVVLARPAFGAPGKPQAVWIKSVAWAGVSLGILGLLLAVAKYTDILMALPSASS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JIK8</accession>
    <name>A0A2M9JIK8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cytochrome C biogenesis protein ResC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_37215</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000026">
        <property type="protein sequence ID" value="PJN06726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN06726">
        <property type="protein sequence ID" value="PJN06726"/>
        <property type="gene ID" value="CG723_37215"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017004">
        <property type="term" value="P:cytochrome complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003834">
        <property type="entry name" value="Cyt_c_assmbl_TM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02683">
        <property type="entry name" value="DsbD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="25"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="72"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="107"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="140"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="185"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="219"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="domain" description="DsbD" evidence="2">
        <location>
            <begin position="31"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN06726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="258" mass="27141" checksum="22E2B4699CBB8357" modified="2018-04-25" version="1">MHATLTALAAEGGVSNTVESGALLLALPIAVLGGLLSFFSPCVLPLVPGYLSYVTGVSGTDLADARRGRMALGAGLFVLGFTAVFVSGGALFGYFGETLQEYQDTLTKILGVLMVLMGIFFMGMMPWLTQREFRFHKRPVTGLIGAPVLGALFGIGWTPCIGPTLASVTALSFNEASAGRGAILTVAYCAGLGVPFVLAAVAFRKALGAFGWVKKHYAWVMRIGGIMMIFTGVLLLTGAWDTLVQQMQTWSNGFTVGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-09-29" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JJG6</accession>
    <name>A0A2M9JJG6_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 9">FAD:protein FMN transferase</fullName>
            <ecNumber evidence="3 9">2.7.1.180</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CG723_36100</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CB01635</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Flavin transferase that catalyzes the transfer of the FMN moiety of FAD and its covalent binding to the hydroxyl group of a threonine residue in a target flavoprotein.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>FAD + L-threonyl-[protein] = AMP + FMN-L-threonyl-[protein] + H(+)</text>
            <dbReference type="Rhea" id="RHEA:36847"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11061"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:74257"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.7.1.180"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 9">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the ApbE family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.180" evidence="3 9"/>
    <dbReference type="EMBL" id="NNBL01000024">
        <property type="protein sequence ID" value="PJN07015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN07015">
        <property type="protein sequence ID" value="PJN07015"/>
        <property type="gene ID" value="CG723_36100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017013">
        <property type="term" value="P:protein flavinylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.520.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024932">
        <property type="entry name" value="ApbE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003374">
        <property type="entry name" value="ApbE-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30040">
        <property type="entry name" value="PTHR30040"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02424">
        <property type="entry name" value="ApbE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143631">
        <property type="entry name" value="SSF143631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0274">FAD</keyword>
    <keyword evidence="5 9" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="8 9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00016337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU363002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PJN07015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="246" mass="26313" checksum="4AA4CF6040BF385D" modified="2018-04-25" version="1">MGTVFSFDIRDTPTPAIHCALAEAVRHLHRMDAVFSTYRPDSHISRLDRGDIRLADCPPEVHEALSLCARAAHRSDGWFSITPAGTLDPSGLVKGWATETASQLLCEAGAHHTCVNGGGDLQLRGGATLDSPWRIGIAHPLRPKELLTVITADTDLAIATSGVAERGAHIYDPHHGAPATTFASLTVVGPRLTMTDAYATAAFARGEDARGWLTSLDGYEALAVRPDGQTWQTPGFARYERIPAGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JJJ1</accession>
    <name>A0A2M9JJJ1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_35560</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000023">
        <property type="protein sequence ID" value="PJN07051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN07051">
        <property type="protein sequence ID" value="PJN07051"/>
        <property type="gene ID" value="CG723_35560"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043917">
        <property type="entry name" value="DUF5753"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19054">
        <property type="entry name" value="DUF5753"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="20"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN07051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="288" mass="31909" checksum="5D73CDF041A35006" modified="2018-04-25" version="1">MSAGESSGSVVRRILLGSQLRRLRESRGITREAAGYSIRASESKISRMELGRVSFKARDVEDLLTLYGVADEAERGALLSLVKEANVAGWWHTYSDVLPGWFPTYVGLEGAASLIRAYEVQFVHGLLQTEGYAHAVVARGMKDAPKADIDRRVALRLERQKLLVSERAPEFHVVLDEAALQRPYGGRKVLQGQLQHLIDVSERPNVTLQVMPFGFGGHSGETGAFAMLSFPESDLSDIVYMEQLTSALYLDKREDVTQYARSMKQLQSECPTPQESVDIIRGLLAKNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JJL0</accession>
    <name>A0A2M9JJL0_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Inorganic pyrophosphatase</fullName>
            <ecNumber evidence="5">3.6.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Pyrophosphate phospho-hydrolase</fullName>
            <shortName evidence="5">PPase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">ppa</name>
        <name evidence="6" type="ORF">CG723_35640</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CB01635</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>diphosphate + H2O = H(+) + 2 phosphate</text>
            <dbReference type="Rhea" id="RHEA:24576"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="EC" id="3.6.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homohexamer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the PPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.1" evidence="5"/>
    <dbReference type="EMBL" id="NNBL01000023">
        <property type="protein sequence ID" value="PJN07066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN07066">
        <property type="protein sequence ID" value="PJN07066"/>
        <property type="gene ID" value="CG723_35640"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004427">
        <property type="term" value="F:inorganic diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006796">
        <property type="term" value="P:phosphate-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00412">
        <property type="entry name" value="pyrophosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.80.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00209">
        <property type="entry name" value="Inorganic_PPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008162">
        <property type="entry name" value="Pyrophosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036649">
        <property type="entry name" value="Pyrophosphatase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10286">
        <property type="entry name" value="PTHR10286"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00719">
        <property type="entry name" value="Pyrophosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50324">
        <property type="entry name" value="SSF50324"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Proton acceptor" evidence="5">
        <location>
            <position position="89"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="8"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="16"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="30"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="42"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="52"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="57"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="84"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="89"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="126"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PJN07066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="163" mass="18637" checksum="F5B05A384AE7C148" modified="2018-04-25" version="1">MEFDVTIEIPKGSRNKYEVDHETGRIRLDRRLFTSTSYPADYGFVENTLGEDGDPLDALVILEEPTFPGCLIKCRAIGMFRMTDEAGGDDKLLCVPASDPRVEHLRDIHHVSEFDRLEIQHFFEVYKDLEPGKSVEGADWVGRTEAEAEIERSYKRFKDEGGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JJL2</accession>
    <name>A0A2M9JJL2_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SBP_bac_5 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_36385</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000024">
        <property type="protein sequence ID" value="PJN06967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN06967">
        <property type="protein sequence ID" value="PJN06967"/>
        <property type="gene ID" value="CG723_36385"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042597">
        <property type="term" value="C:periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030678">
        <property type="entry name" value="Peptide/Ni-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039424">
        <property type="entry name" value="SBP_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000914">
        <property type="entry name" value="SBP_5_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30290">
        <property type="entry name" value="PTHR30290"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00496">
        <property type="entry name" value="SBP_bac_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002741">
        <property type="entry name" value="MppA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SBP_bac_5" evidence="1">
        <location>
            <begin position="73"/>
            <end position="444"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN06967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="523" mass="56322" checksum="8881483439C460E5" modified="2018-04-25" version="1">MAAIAALALAATGCSGGGSDGKGSGAAGRTVTVATGAEIAAINPEKDNSSANIQLAFAMWAPLTRVDPKSGKLVNVVADSVTSKDAKTWTIKIKPGWKFTNGEKLTAKSFVDTWNYTAYGPHGYLSNGFFQRVQGYEDLNPAKGKPKATTLSGLKVVDDLTFTVTLKAPFSPYPSTLSYYGLAALSAETLKDPDAYSHKPIGYGPYKLDGAWKAGQPVRLTRNKGYAGKDAPQADRLVYRFFSNPETAYNEFLAGNLDYATLPSSKIDAYKTDAPGKWSQGKSAPNLSYLELPVNTPGFKDPKVRRALSLALDRKALVKLKPGAFPATSFTASTLDGHRENTCTACTLDVAGAKKLLREAGGFSGRLKMYYASDNPGDQVFAEALGNMWRQSLGLKIQYVGKPGSDLSAMASKGALDGVRSSGWGHDYPSLEDYLTPIFASYGDFNSNGYRNPEVDSRLEQANKIADPAKATRAYQGIEDLIARDMPVVPLFHTRTIYLHATDVHPLDSRYADINPVRSTIDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JJN1</accession>
    <name>A0A2M9JJN1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DNA-binding response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CG723_35760</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000023">
        <property type="protein sequence ID" value="PJN07089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN07089">
        <property type="protein sequence ID" value="PJN07089"/>
        <property type="gene ID" value="CG723_35760"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00622">
        <property type="entry name" value="HTH_LUXR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="4"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="domain" description="HTH luxR-type" evidence="3">
        <location>
            <begin position="150"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PJN07089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="224" mass="24068" checksum="55359F59E85974B3" modified="2018-04-25" version="1">MAIRVMLVDDQVLLRTGFRMVLAAQPDMEVVAEAGDGVEALEVLRGTAVDVVLMDVRMPKLDGVETTRRICLEDNPPKVLILTTFDLDEYAFSGLKAGASGFMLKDVPPGELLGAIRAVHSGDAVVAPSTTRRLLDRFAPMLPSSGKEPQLAELGRLTEREREVMILVAQGLSNGEIAARLVLSEATVKTHVGRILTKLNLRDRVQVVVLAYETGLVRAGGGAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JJW5</accession>
    <name>A0A2M9JJW5_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">ATP-dependent 6-phosphofructokinase</fullName>
            <shortName evidence="10">ATP-PFK</shortName>
            <shortName evidence="10">Phosphofructokinase</shortName>
            <ecNumber evidence="10">2.7.1.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Phosphohexokinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">pfkA</name>
        <name evidence="12" type="ORF">CG723_34730</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">CB01635</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>ATP + beta-D-fructose 6-phosphate = ADP + beta-D-fructose 1,6-bisphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16109"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:32966"/>
            <dbReference type="ChEBI" id="CHEBI:57634"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.11"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 10">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 10">Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 3/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Homodimer or homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 10">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the phosphofructokinase type A (PFKA) family. Mixed-substrate PFK group III subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.11" evidence="10"/>
    <dbReference type="EMBL" id="NNBL01000022">
        <property type="protein sequence ID" value="PJN07154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN07154">
        <property type="protein sequence ID" value="PJN07154"/>
        <property type="gene ID" value="CG723_34730"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00182"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003872">
        <property type="term" value="F:6-phosphofructokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047334">
        <property type="term" value="F:diphosphate-fructose-6-phosphate 1-phosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006002">
        <property type="term" value="P:fructose 6-phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.460">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01976">
        <property type="entry name" value="Phosphofructokinase_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022953">
        <property type="entry name" value="ATP_PFK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012003">
        <property type="entry name" value="ATP_PFK_prok-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015912">
        <property type="entry name" value="Phosphofructokinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000023">
        <property type="entry name" value="Phosphofructokinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012829">
        <property type="entry name" value="Phosphofructokinase_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035966">
        <property type="entry name" value="PKF_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00365">
        <property type="entry name" value="PFK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000532">
        <property type="entry name" value="ATP_PFK_prok"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00476">
        <property type="entry name" value="PHFRCTKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53784">
        <property type="entry name" value="SSF53784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02483">
        <property type="entry name" value="PFK_mixed"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00433">
        <property type="entry name" value="PHOSPHOFRUCTOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 10" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="7 10 12" id="KW-0418">Kinase</keyword>
    <keyword evidence="8 10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10 12" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PFK" evidence="11">
        <location>
            <begin position="2"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="10">
        <location>
            <begin position="125"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="10">
        <location>
            <begin position="169"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="10">
        <location>
            <begin position="272"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="10">
        <location>
            <position position="127"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="10"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="72"/>
            <end position="73"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="102"/>
            <end position="105"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="103"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="162"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="222"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="266"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="site" description="Important for substrate specificity; cannot use PPi as phosphoryl donor" evidence="10">
        <location>
            <position position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PJN07154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="341" mass="36199" checksum="AB94EBE40D205B4F" modified="2018-04-25" version="1">MRIGVLTSGGDCPGLNAVIRSVVHRAVVDHGDEVIGFHDGWKGLLECDYRKLDLDAVGGILARGGTILGSSRVQPAHLRDGVERAKGHVADLGLDAIIPIGGEGTLKAARLLSDSGLPIVGVPKTIDNDIAVTDVTFGFDTAVGVATEALDRLKTTAESHQRVLIVEVMGRHTGWIALHSGMAAGAHAIVVPERPFDIEELAAKVGERFSAGKKFAIVVAAEGAKPAPGSMEFDEGVKDMYGHERFAGIATRLSGELEQRLGKEARPVILGHVQRGGTPTAYDRVLATRFGWHAVEAVHRGEFGMMTALRGTDIVMVSLAEAVETLKTVPQERYAEAECVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JK19</accession>
    <name>A0A2M9JK19_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DUF4442 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CG723_35080</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000022">
        <property type="protein sequence ID" value="PJN07215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN07215">
        <property type="protein sequence ID" value="PJN07215"/>
        <property type="gene ID" value="CG723_35080"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027961">
        <property type="entry name" value="DUF4442"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14539">
        <property type="entry name" value="DUF4442"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="SSF54637"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PJN07215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="145" mass="15067" checksum="62DF9BD0B21A7BCD" modified="2018-04-25" version="1">MSIGEMLAATVPMARTLNIEFLETTPEKAVVALPDQSEYHNHVGGPHAGAMFTLGESASGAIVLAAFGDQLSRAVPLAVRADIAYKKLAMGPVTATATLGRPAADVVAELDAGERPEFPVAVAIQRADGAITGEMTVVWTLRPNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JKI3</accession>
    <name>A0A2M9JKI3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_34550</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000021">
        <property type="protein sequence ID" value="PJN07373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN07373">
        <property type="protein sequence ID" value="PJN07373"/>
        <property type="gene ID" value="CG723_34550"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="460"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="959"/>
            <end position="1014"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1104"/>
            <end position="1130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1198"/>
            <end position="1222"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="864"/>
            <end position="905"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1293"/>
            <end position="1320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="461"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="959"/>
            <end position="995"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1109"/>
            <end position="1130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN07373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="1563" mass="167577" checksum="4D1A56F2D06D7877" modified="2018-04-25" version="1">MYELSRIRLYSIGPAGARYADTVLDLRGVGEPVPDPAPTQAEFFEDEPVGPPRRPAPAGVLFLENGGGKSVLLKLIFSVMLPGHRNTLGGASSGVLRKFLLADDCGHVALEWQHTLTGECVVVGKVSEWRGRQVSNDPRKFAEAWYSLRPGPGMSLDSLPVAESSAVRASAEGVSGAQGRRRTMKGFRDALTDAGKAYPHLEVHWEEIHDRWNEHLGELGLDPELFRYQREMNADEGEAAGLFAVKKDSDFTDLLLRAVTDTRDTDGLADLVSGFGNKLGRRAELIAEREFTAGSVDLLGRIVDAADTRARARDVHAGAERRTRTLARRLAARAALERGRAADLAQQVTAAAHTVGEAEQARGRSALIASELAYRHASLALAGAEKAAAAQKRELADARTLHAAWQAAEAVLRHRAAADRSARVAVAIREAERDAAPALAARAEAAADLVRALHGAAESAEELANEGEERSAALQEAGETAHRDATVAATEAQRARSEVGHLRQRLSEVEQETAEAVRAGWLDDTAPDADPARAALAASDAEKTTVAAWDTARDAARRANEHARETAGAEARAELTAARAADAATAAENAYGAEHRAAGSLAREERVAELLGLSGVPGIPAAGVPAPRGAVAGGAATRHARVATVTRDLGETPLTAEELDRAADDLKALLDDGVASAERQLFDLRTAAADDARILGALGDGGLLPPGPDVLATVEFLGEHGIPALPGWRYLAQAVDPVDHARVLAARPELVDGVVITDPDTHARAREALAGAALLPRSAVAVGTAAALLAPTPHEETGDSGVFLVPPNPAMHDEHAADEERQALRTRATERDEEIRALAARLSKDRELAARIGSWRTGCPDGRLAELAAAAQEARAFADETEAELAEARTVRAEAEETAVEATRVRDERQDAAQRARRVADALAGLAFRLRERAGWQVKVRELADEALESEARAQTCLERARSADEDRRAAQRAADDARRTARALRAERAEIAGAPDDVPADPEQPSPQAPKPSLPALREAYRAASQVYEKVGVGADLRAEQARAESDESAALAELDRLSNKVRTRAAQLLQSPDGSDGPSRQAAAARADELVQLLEARVSTASEQLGRLRGEAERHAPEDGDDAHTELPDDLVPTGAEHAQTLLRTATGELAARTEALTVARAAHSELLDAHRAAEDATGGFEETAALLKDLLREHPDRHESEQDEPEPYPGTLEEARHAAAEARRSLRGCAADLSAAEAAVRDASDILVRHANATRYEQVRTPARQQIRELPASALPEHAQKWADAFAPRLRVLTDELEQLERNRDSIVDRLRGLVESALATLRSAQRLSRLPEGLGEWSGQEFVRIRFEEPDQATLVERLGEVVDEATRAAVKKNSDLRRDGMSLLLRGVGAALQPKGIAVEILKPDAVLRAERVPVGQMGDVFSGGQLLTAAIALYCTMAALRSNDRGRDKHRHAGTLFLDNPIGRANATYLLELQRAVSDALGVQLLYTTGLFDTTALAEFPLVIRLRNDADLRAGLKYISVEEHLRPGLPQQDPAEETVHGEITATRMYKRPANHPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-05-25" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JKM4</accession>
    <name>A0A2M9JKM4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CG723_34360</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CB01635</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000021">
        <property type="protein sequence ID" value="PJN07337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN07337">
        <property type="protein sequence ID" value="PJN07337"/>
        <property type="gene ID" value="CG723_34360"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04590">
        <property type="entry name" value="CBS_pair_CorC_HlyC_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002550">
        <property type="entry name" value="CNNM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044751">
        <property type="entry name" value="Ion_transp-like_CBS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005170">
        <property type="entry name" value="Transptr-assoc_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03471">
        <property type="entry name" value="CorC_HlyC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01595">
        <property type="entry name" value="DUF21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01091">
        <property type="entry name" value="CorC_HlyC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="SSF54631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="SSF56176"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51846">
        <property type="entry name" value="CNNM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0129">CBS domain</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="CNNM transmembrane" evidence="10">
        <location>
            <begin position="1"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="9">
        <location>
            <begin position="222"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="9">
        <location>
            <begin position="287"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PJN07337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="444" mass="47277" checksum="23F0737A8563C757" modified="2018-04-25" version="1">MTIPLLLLGAAFLLILANGFFVAAEFGLVTVERADAEKAAADGDRRARTVVNALKELSFQLSGTQLGITITSLVVGMLAEPALATLLAGPFTAVGIPEGAVGGVSVVIGMLLASAVQMVIGELVPKNWAVSKPLQVARFVAGPQHAFSRLFRPVIALLNAVANRAVRALGVEPADELASARTPGELVSLARHSAQAGTLEQDTADLFVRTLSLGELTAQHVMTPRVKVSALQSSATAEDVVNLTRATGLSRFPVYRERIDEIVGMVHLKDALAVPAHDRLRTPVSRIAQAPLLVPETLPVQPLLERLRSEQPIAVVVDEYGGTAGVVTLEDIVEELVGEVRDEHDRLDLPELAVAPSEDGRPAWDADGSCRVDILRRIGLDVPEGPYETVAGLVADLLGRIPAPGDRAELPGWRLAVRQVDHYRAERVRIVRTADAARPAEAAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JKQ2</accession>
    <name>A0A2M9JKQ2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Dihydroxyacetone kinase subunit L</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">dhaL</name>
        <name evidence="2" type="ORF">CG723_33595</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000020">
        <property type="protein sequence ID" value="PJN07438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN07438">
        <property type="protein sequence ID" value="PJN07438"/>
        <property type="gene ID" value="CG723_33595"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004371">
        <property type="term" value="F:glycerone kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006071">
        <property type="term" value="P:glycerol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.340">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012737">
        <property type="entry name" value="DhaK_L_YcgS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004007">
        <property type="entry name" value="DhaL_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036117">
        <property type="entry name" value="DhaL_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02734">
        <property type="entry name" value="Dak2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01120">
        <property type="entry name" value="Dak2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101473">
        <property type="entry name" value="SSF101473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02365">
        <property type="entry name" value="dha_L_ycgS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51480">
        <property type="entry name" value="DHAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DhaL" evidence="1">
        <location>
            <begin position="5"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN07438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="200" mass="20490" checksum="66F9F10CAA79B0EA" modified="2018-04-25" version="1">MLDADFFRRWLNVATAAVDREAARLTELDSPIGDADHGSNLQRGFVAVSAVLEKEAPATPGDVLTLAGRQLISTVGGASGPLYGTLLRRTGKELGDTPEVSEAEFTAALRAGVDAVMTLGGAAPGDKTMIDALVPAVDALDTSFDAAATAAEQGALATTPMQARKGRASYLGERSIGHQDPGATSSALLIGALVEAARDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JKZ2</accession>
    <name>A0A2M9JKZ2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_32775</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000019">
        <property type="protein sequence ID" value="PJN07546.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN07546">
        <property type="protein sequence ID" value="PJN07546"/>
        <property type="gene ID" value="CG723_32775"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014876959" evidence="2">
        <location>
            <begin position="44"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="45"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN07546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="227" mass="22898" checksum="1CBAD74D2E84F018" modified="2018-04-25" version="1">MPSPFPKLSTSLEQGRPHSRLRLLGLLAVVVLTVLLPLAGASAGPVGDAAAEDSLNSGELPTGNADSADKVDDKPGASESDMADTAATDAAGKARRSHGRPPGTSVLAGLGIATTARCGPELASPDGIEAQTCVLTQGRDTWARTYYRNATGGPLSSVLTLMAPAGRTVQMYCVVGAQDEPGTCDTPRERTSGEASAYSAVAEFAGAGDAGPLLLRSGSNAPTPPGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-09-29" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JLS4</accession>
    <name>A0A2M9JLS4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">1-acyl-sn-glycerol-3-phosphate acyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_32165</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000018">
        <property type="protein sequence ID" value="PJN07727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN07727">
        <property type="protein sequence ID" value="PJN07727"/>
        <property type="gene ID" value="CG723_32165"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002123">
        <property type="entry name" value="Plipid/glycerol_acylTrfase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01553">
        <property type="entry name" value="Acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00563">
        <property type="entry name" value="PlsC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PlsC" evidence="1">
        <location>
            <begin position="41"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN07727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="229" mass="24891" checksum="BCE339FF6D7255D8" modified="2018-04-25" version="1">MTPEGPLSRFAFIKAVLSPIMRLMFRPRVEGAENIPGTGPVILAGNHLTFIDSIVLPIVCDRQVLFIGKDEYVTGKGLKGRVMAWFFTGVGMIPVDRDGANGGVAALMTGRRVLEEGQVFGIYPEGTRSPDGRLYRGRTGIARLTLMTGAPVVPFAMIGTDKLQPGGSGLPRPGRVTVRFGEPMEFSRYDGMGRDRYVLRAVTDSVMAEVMRLSGQEYVDMYATKAKAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JM12</accession>
    <name>A0A2M9JM12_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_31445</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000017">
        <property type="protein sequence ID" value="PJN07899.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN07899">
        <property type="protein sequence ID" value="PJN07899"/>
        <property type="gene ID" value="CG723_31445"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002577">
        <property type="entry name" value="HTH_HxlR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01638">
        <property type="entry name" value="HxlR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51118">
        <property type="entry name" value="HTH_HXLR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH hxlR-type" evidence="1">
        <location>
            <begin position="20"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN07899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="128" mass="14481" checksum="682ABB1B03C1A709" modified="2018-04-25" version="1">MTTHDADPMRVLNGRDDTTCRVRDVLDRVGSKWSLTVINELGPGTRRCTEIKNAVPGISQRMLTETLRGLERDGLISRTVHPVVPPRVDYELTSLGRTLLDTVRTLLDWALDHIDDIDKARDVYDTRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JM21</accession>
    <name>A0A2M9JM21_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Thiosulfate sulfurtransferase</fullName>
            <ecNumber evidence="2">2.8.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CG723_31520</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CB01635</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>hydrogen cyanide + thiosulfate = 2 H(+) + sulfite + thiocyanate</text>
            <dbReference type="Rhea" id="RHEA:16881"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17359"/>
            <dbReference type="ChEBI" id="CHEBI:18022"/>
            <dbReference type="ChEBI" id="CHEBI:18407"/>
            <dbReference type="ChEBI" id="CHEBI:33542"/>
            <dbReference type="EC" id="2.8.1.1"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.8.1.1" evidence="2"/>
    <dbReference type="EMBL" id="NNBL01000017">
        <property type="protein sequence ID" value="PJN07909.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN07909">
        <property type="protein sequence ID" value="PJN07909"/>
        <property type="gene ID" value="CG723_31520"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004792">
        <property type="term" value="F:thiosulfate sulfurtransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001307">
        <property type="entry name" value="Thiosulphate_STrfase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045078">
        <property type="entry name" value="TST/MPST-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11364">
        <property type="entry name" value="PTHR11364"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00581">
        <property type="entry name" value="Rhodanese"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00450">
        <property type="entry name" value="RHOD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52821">
        <property type="entry name" value="SSF52821"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00380">
        <property type="entry name" value="RHODANESE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Rhodanese" evidence="4">
        <location>
            <begin position="18"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodanese" evidence="4">
        <location>
            <begin position="165"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PJN07909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="282" mass="28938" checksum="AC0FBFB7B2FAB9B6" modified="2018-04-25" version="1">MTARVTTTVAELDTLLHSDAPPVLLDVRWALGDPHGRVHYAAGHIPGAVYVDLDTELAAPPSPTGGRHPLPDLADLQAAARGWGVRAGRPVVVYDDSGNTAAARAWWLLRYAGVADVTLLDGALSAWRSAGQPLESGAPADQAPGDIVLRPGGLPVTDADGAAELVARGLLLDARAAERYRGEVEPVDPRAGHIPGAVSAPTGENLAADGTFLPAEVLRKRFASRGAAEAARVGVYCGSGVTAAHQIAALALAGFDATLFPGSWSSWSADPARPAVTGPLPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-09-29" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JM26</accession>
    <name>A0A2M9JM26_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">FAD-binding oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_31555</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000017">
        <property type="protein sequence ID" value="PJN07915.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN07915">
        <property type="protein sequence ID" value="PJN07915"/>
        <property type="gene ID" value="CG723_31555"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.45.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016164">
        <property type="entry name" value="FAD-linked_Oxase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004113">
        <property type="entry name" value="FAD-linked_oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016171">
        <property type="entry name" value="Vanillyl_alc_oxidase_C-sub2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02913">
        <property type="entry name" value="FAD-oxidase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55103">
        <property type="entry name" value="SSF55103"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="SSF56176"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="2">
        <location>
            <begin position="50"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="29"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN07915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="463" mass="47462" checksum="4BF0275C458951E4" modified="2018-04-25" version="1">MTTPAAPAAPATTTSARLLGLLARDLAPDRLTTDPPTLAAHATDRSGTRPDGIPLAVVHAQRTEDVTVTLRHAHALRVPVVPRGAGTGLSGGATAGEGDLVLDLSGMNRILELSPDDQLAVVEPGVITAELDRAAAAHGLRYAPDPASAALSTIGGNIATNAGGLRCAKYGVTRDSVLGLEVVLADGTVVRTGRRTVKGVTGYDLTALLTGSEGTLAVITSATLRLRPVPVATATLAAYFASFEAAAEATYAIGRAGVEPALAELVDGPVLHAIDPALRERGSALLLVQCDGAGAAAEAETVARLLAPLATTVETTADPAEAEALLAARRLALPALERLGRPLIEDIAVPRSRLAEAVTEIRAISIRHDVPVFTIAHAADGNLHPIIVVDPSLPGLPDAAWEAAGEIFALALRLGGTLTGEHGVGVLKRQWVADELGPAAHALQRRLKDAFDPQGILNPGKSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-09-29" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JM33</accession>
    <name>A0A2M9JM33_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PRC domain containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_31650</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000017">
        <property type="protein sequence ID" value="PJN07929.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN07929">
        <property type="protein sequence ID" value="PJN07929"/>
        <property type="gene ID" value="CG723_31650"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030077">
        <property type="term" value="C:plasma membrane light-harvesting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045156">
        <property type="term" value="F:electron transporter, transferring electrons within the cyclic electron transport pathway of photosynthesis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019684">
        <property type="term" value="P:photosynthesis, light reaction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.50.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014747">
        <property type="entry name" value="Bac_photo_RC_H_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011033">
        <property type="entry name" value="PRC_barrel-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50346">
        <property type="entry name" value="SSF50346"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="89"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN07929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="116" mass="12756" checksum="5273FF5B8865AB16" modified="2018-04-25" version="1">MSDSIWGYQPTAGHTAGTDLIGYKVEATDGSIGKVDKHSDDVNSAYLVVDTGVWIFGRHVLLPAGTVRTVDQAERKVFVDLTKDQIKGSPEFDRDKHVGDAGYHEQVGSYYTSRRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JM50</accession>
    <name>A0A2M9JM50_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CG723_31525</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CB01635</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000017">
        <property type="protein sequence ID" value="PJN07951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN07951">
        <property type="protein sequence ID" value="PJN07951"/>
        <property type="gene ID" value="CG723_31525"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="89"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="122"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="148"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="188"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="243"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="82"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PJN07951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="280" mass="29992" checksum="6CA9DC461BD2E96D" modified="2018-04-25" version="1">MDIAPSKGAPAPRVIIRGTARTARRLTVPRSVRRAAGPAGLVLLWLLTSTTGVLPESVLASPMDVLDQAVELTKSGELPSAIAASGRRAATGFLIGAVIALSLSLLAGLFRLGEDVIDSSMGMFRAIPWVGLIPLFIVWFGIEETPKIALVALGVTYPLYFNIYGGIRSTDSQLVEAARMMGLSRLGLIRYVILPSALPGALVGLRYALSTAWLALVFAEQVNADAGLGYLMSNAQQYFRTDIIVLCLVVYALLGLACDFAVRILSRRLLTWRSNFDGEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JM71</accession>
    <name>A0A2M9JM71_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CG723_31720</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000017">
        <property type="protein sequence ID" value="PJN07958.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN07958">
        <property type="protein sequence ID" value="PJN07958"/>
        <property type="gene ID" value="CG723_31720"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PJN07958.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="95" mass="9791" checksum="76F18CB85FD46254" modified="2018-04-25" version="1">MGLLLDVEDTAVTRQTTEAQARVGTVGAIRLIAFAVAEADDNQADWLQTGIYDALVGPDGVPDIAAACGKLALDAEEAVRRSAADISAWTDGTGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JMB6</accession>
    <name>A0A2M9JMB6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ABC transporter substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_30345</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000016">
        <property type="protein sequence ID" value="PJN07998.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN07998">
        <property type="protein sequence ID" value="PJN07998"/>
        <property type="gene ID" value="CG723_30345"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006059">
        <property type="entry name" value="SBP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13416">
        <property type="entry name" value="SBP_bac_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014760766" evidence="1">
        <location>
            <begin position="34"/>
            <end position="413"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN07998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="413" mass="44388" checksum="F993BF3593E8F05E" modified="2018-04-25" version="1">MTRTKSVSVAATVVVAALALTSCGSSGGEQVAADKKQTLTVWAMGEEGTRLKAVTDEFTKQHPNITVKVTPVGWDVVHQKLVSAIAAKKTPDMAQMGSTMMGEFIALDALEPVDTKTFKKSDFFPATWDSNVKDGTAYGVPWYADTRALYYRTDLAEKAGVDKAPTTWKDQQALAAAYQKSGTEWGTDLQPSSTGAWQSWVQYLYSAGGELIGKDGKPALDSPEAIRAFTEWASYFKKGLAKKTFTPGYDVTKDFASGKRPMFQSGPWMVRNIADQQPQLKGKYKVVPVPADKTSTSWVGGASLVTFKNSAHKAAAEELTQYLTTPKTQAQWYEADKALPASKAAWDEPALKSGGESLATFKASLDTAKAIPPLEKWNEFAAAVEGALAKISQGADPAATAKTLQKTAEGLVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JN50</accession>
    <name>A0A2M9JN50_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycosyl transferase family 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_28255</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000014">
        <property type="protein sequence ID" value="PJN08296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08296">
        <property type="protein sequence ID" value="PJN08296"/>
        <property type="gene ID" value="CG723_28255"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_2-like" evidence="1">
        <location>
            <begin position="1"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN08296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="369" mass="41612" checksum="F5FC65A713A4338F" modified="2018-04-25" version="1">MIVKNESGVIERCLASVRDLITTWVISDTGSTDGTQKIIRNALRDIPGELHEEPWVDFGQNRSLNISHARGKADYLLLLDADHEIRQDDALPPLTADAYMLRHEGAFEYWIRRLVRGDIAWRYEGVTHEYLTADEPADQSRLDALAIVDHADGGSRHDKSERDARLLSAELERDPDNPRTVFYLAQTMRDMGRNEEAIALFEGRAAMGGWPEEVYFSQFQAGVLKAETGDWPGAMDALVRAWETRPERLEACYQLCSRLRAMGHYRAAHAFASAGLNRPVPDDLLFVSPWVYRWGLLFEFSITAYCVGDWAGSYQACDRLLAMPDLPEAIREQTLANREFPAQRLSKVWASLWSTARTCAGPGGREAPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JN99</accession>
    <name>A0A2M9JN99_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">SLATT_2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CG723_28560</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000014">
        <property type="protein sequence ID" value="PJN08342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08342">
        <property type="protein sequence ID" value="PJN08342"/>
        <property type="gene ID" value="CG723_28560"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040688">
        <property type="entry name" value="SLATT_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18183">
        <property type="entry name" value="SLATT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="83"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="113"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="domain" description="SLATT_2" evidence="3">
        <location>
            <begin position="34"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="214"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="224"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF18183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PJN08342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="253" mass="27447" checksum="A37CB19D9F32FC2A" modified="2018-04-25" version="1">MSQPEMQPEGPPQEERGARGESSDGTGDAVRPGDLTGRAFPVGDWGEPAERLDELYRWVERGALDTAYWYLADRVWKRRGARALRGGAVVGAVSGAALPLLDLTGALGGVAPWGYLALLLAVACVACDRYFGLTSGWIRDVATAQAVQRRLQALQFDWASESVREVLGPTEGTASEAAERCLSVLRRFTDDVTELVRAETADWMVEFRSGPAPLVMQSSVTPGTRPVEPPPGRFPLPPGARPNMPRQRPPEPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JNE7</accession>
    <name>A0A2M9JNE7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CG723_28840</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000014">
        <property type="protein sequence ID" value="PJN08392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08392">
        <property type="protein sequence ID" value="PJN08392"/>
        <property type="gene ID" value="CG723_28840"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.130">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013517">
        <property type="entry name" value="FG-GAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013519">
        <property type="entry name" value="Int_alpha_beta-p"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028994">
        <property type="entry name" value="Integrin_alpha_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01839">
        <property type="entry name" value="FG-GAP"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00191">
        <property type="entry name" value="Int_alpha"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69318">
        <property type="entry name" value="SSF69318"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51470">
        <property type="entry name" value="FG_GAP"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014631254" evidence="4">
        <location>
            <begin position="31"/>
            <end position="460"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PJN08392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="460" mass="46445" checksum="CBB7CAC4C8D45252" modified="2018-04-25" version="1">MRMRKLVIAAGAAVVAAAGLTLPLAGTASAATTLKDDFNGDGYRDLAVGTPGANSVTVTFGSASGVSPSHAVTVTQSTAGVPGVTEPEDEFGENVTSGDVDDDGYADLIVGAPGERVTGNTTGSVTIVWGGPKAFNKGAKVLNSPTTDTERFGEGTSFVDIDGDEAENLAVISADGWWYYAESEDPTRAIAPEVDFLPDGVHLEGMEAAHFLSKDGYTYVLYGERADGKPYSVYMKGGVGDIGYYSGVVAEGDDPRATREAAAAADVNGDGYTDLVTGNAAANSVTVRYGAQGSFGTTKTYTQDSAGVPGADEPEDRFGAAVSAGDLDHDGYADVAVGAPGESVGTVTGTGSVTVLKGGTGGLGAGRAYHQDTAGVPGVPEAGDHFGSSLRFKDINKNSRADLAIGANGEDIGTSADAGAVWVLRGAVPYVTTSYATSFNGADFGTATSGAGRAFGTVLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JNZ7</accession>
    <name>A0A2M9JNZ7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CG723_27950</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000013">
        <property type="protein sequence ID" value="PJN08596.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08596">
        <property type="protein sequence ID" value="PJN08596"/>
        <property type="gene ID" value="CG723_27950"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005079">
        <property type="entry name" value="Peptidase_C45"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03417">
        <property type="entry name" value="AAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PJN08596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="372" mass="38478" checksum="5EAEA7EDF9A4B67C" modified="2018-04-25" version="1">MGATVREQQLAGLRWLVVSGSRDDAFRALGETARADIHAVQEAMPEREALRRATAAPAGAARLDRVVTATREAFPGELAELAALAEGSGVPFDDLLLANLRGDLGVGDGTGCTDLGRRGGSGAFVAHNEDGAPALDGRLMLLTLLIEGQAPVTAQWYPGFVPANAFTATGNGLVWGINHIQVVRPGPGAGRHFAARALQQAPTLDAALDLLRTRPTAGGFAYTIGERATGRIAVVEAAAGRTAMVEAGPDELHWHTNHIRLLPDAPDAALSGGGEGATADLGQYAESAARGRALERLSPGDAPDAEWFVSALTSAPLPDGVHRTAAGDDPLMTLCTTVSDLGRDRITVRGARGEHAVLPLSAFTEGAVPAAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JP47</accession>
    <name>A0A2M9JP47_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CG723_28090</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000013">
        <property type="protein sequence ID" value="PJN08615.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08615">
        <property type="protein sequence ID" value="PJN08615"/>
        <property type="gene ID" value="CG723_28090"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PJN08615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="170" mass="18825" checksum="76E56D328EE5BDF3" modified="2018-04-25" version="1">MDSFTEFIEESDLDTRIEPELSEVAVLQRLGPTGTGDLVWMPDADTYCLTTIRSSLKSHGCYGLAPKRPARGYVQVGDPTPRGVGSTYSKQDWLSVSLVENTQGLFTFTGDRPKGTSSVRQATLRFTSGRTVTFLAYSQTDSRIPQNTKICGPHRKVCFDPYDFDLGRVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JPA5</accession>
    <name>A0A2M9JPA5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CG723_28035</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000013">
        <property type="protein sequence ID" value="PJN08627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08627">
        <property type="protein sequence ID" value="PJN08627"/>
        <property type="gene ID" value="CG723_28035"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="1"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="13"/>
            <end position="20"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PJN08627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="271" mass="28511" checksum="AE6B95F91D0B8390" modified="2018-04-25" version="1">MQISAGDVLAVVGDNGSGKSTLLRILVGLSQPTSGTVSGRPPHIGYVPDRFTAHDRIPAISYLTHMGRIRGMSASAARARGNHLLEQLSLVGGRNASLRTLSKGNAQKVALAQALLVQPDLLVLDEPWSGLDASAHGVLTELIDEVAAQGGAVVFTDHREAIAQAHAGGVYVISDGRGTWRDGRHAGRRASMAELVLAVPPTGVMPAEVNWSALPGVVDTVQRDAEVVLQVAREHLDTVLLTALQHRWSVVSLAGTANKHGSRGNARRTAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JPG2</accession>
    <name>A0A2M9JPG2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Enoyl-CoA hydratase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CG723_26640</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000012">
        <property type="protein sequence ID" value="PJN08677.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08677">
        <property type="protein sequence ID" value="PJN08677"/>
        <property type="gene ID" value="CG723_26640"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PJN08677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="257" mass="27532" checksum="83D6E7CBB4018FBA" modified="2018-04-25" version="1">MSVRVETDKESGVAVVTLDRPERHNAIDLVTADELAAVWRGFRFDDSVRAVVITGAGERAFCTGIDRDADVPQPHSPYSIDDPLVAVGPKANDLWKPVVAAVNGMACGGAFYLIGESEFVVADESATFFDPHTTYGMVSAYETIHLAQRMPFGEVARMALMGTAERISARRAHETGLVSELTVPGGALAASVRCAETIASYPTEAVQGTVRAVWAAREAARTQALAHAPQLIALGNLPPERQAELFSARRPGGFRVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JPM0</accession>
    <name>A0A2M9JPM0_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">1,4-alpha-glucan branching enzyme GlgB</fullName>
            <ecNumber evidence="9">2.4.1.18</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">1,4-alpha-D-glucan:1,4-alpha-D-glucan 6-glucosyl-transferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Alpha-(1-&gt;4)-glucan branching enzyme</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Glycogen branching enzyme</fullName>
            <shortName evidence="9">BE</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9 13" type="primary">glgB</name>
        <name evidence="13" type="ORF">CG723_25305</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">CB01635</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>Transfers a segment of a (1-&gt;4)-alpha-D-glucan chain to a primary hydroxy group in a similar glucan chain.</text>
            <dbReference type="EC" id="2.4.1.18"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 9">Glycan biosynthesis; glycogen biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the glycosyl hydrolase 13 family. GlgB subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.18" evidence="9"/>
    <dbReference type="EMBL" id="NNBL01000011">
        <property type="protein sequence ID" value="PJN08823.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08823">
        <property type="protein sequence ID" value="PJN08823"/>
        <property type="gene ID" value="CG723_25305"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00164"/>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003844">
        <property type="term" value="F:1,4-alpha-glucan branching enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102752">
        <property type="term" value="F:1,4-alpha-glucan branching enzyme activity (using a glucosylated glycogenin as primer for glycogen synthesis)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043169">
        <property type="term" value="F:cation binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005978">
        <property type="term" value="P:glycogen biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02855">
        <property type="entry name" value="E_set_GBE_prok_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00685">
        <property type="entry name" value="GlgB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006048">
        <property type="entry name" value="A-amylase/branching_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037439">
        <property type="entry name" value="Branching_enzy"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006407">
        <property type="entry name" value="GlgB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044143">
        <property type="entry name" value="GlgB_N_E_set_prok"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006047">
        <property type="entry name" value="Glyco_hydro_13_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004193">
        <property type="entry name" value="Glyco_hydro_13_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43651">
        <property type="entry name" value="PTHR43651"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00128">
        <property type="entry name" value="Alpha-amylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02806">
        <property type="entry name" value="Alpha-amylase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02922">
        <property type="entry name" value="CBM_48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000463">
        <property type="entry name" value="GlgB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00642">
        <property type="entry name" value="Aamy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="SSF81296"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01515">
        <property type="entry name" value="branching_enzym"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="7 9" id="KW-0320">Glycogen biosynthesis</keyword>
    <keyword evidence="4 9" id="KW-0321">Glycogen metabolism</keyword>
    <keyword evidence="5 9" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aamy" evidence="12">
        <location>
            <begin position="263"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="706"/>
            <end position="728"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="9 10">
        <location>
            <position position="415"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="9 10">
        <location>
            <position position="468"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000463-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PJN08823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="746" mass="83074" checksum="AF0798F796987732" modified="2018-04-25" version="1">MTHDPSRSTPPTPVTAAPSPTSAADRDRLLAGTHHDPHSTLGAHTTPAGTAFRALRPYARAVTVVADGLRVVLHDDGDGFFSGLADLPAPPADYRLLVTYEGAAEHETPDPYGLLPALCEFDLHLIGEGRHEQLWQALGAHPMTHQGITGTRFTVWAPNAQGVRVVGDFNYWNGTGFPMRSLGSTGIWELFVPALGEGELYKFEITRPDGSKTMRADPLARRTEVPPANSSIIDASHHSWHDAEWMARRGTPPVHEAPFSVYEIHLASWRPGLTYRQLADQLPSYVADLGFTHVELMPVAEHPFGGSWGYQVTGFYAPTARMGTPDDFRHLVDALHQAGIGVLMDWVPAHFPRDDWALAEFDGRTLYEHEDPLRAAHPDWGTLEFDYGRKEVRNFLVANAVYWCEEFHIDGLRVDAVASMLYLDYSREHGRWTPNQYGGRENLDAVEFLQEMNATLYRRVPGVVTIAEESTAWDGVTRATHHIGPGGFGGLGFGLKWNMGWMHDSLGYVSHDPVHRSYHHDEMTFSMVYAYSENYVLPISHDEVVHGKKALVSKMPGDWWQQRATQRAYLGFMWSHPGKQLLFMGQEFAQGAEWSEAHGPDWWLLDPSYPAEPDHRGVRDLTRDLNAVYRNEPALWQRDMDPAGFEWIVGDAAQDNVFAFLRRAADGSPLMSVSNFSPVVRHGYRLGAPDDVPAWHEVLNTDAARYGGGDVGNPDPVKPDAQGAHGRPASVRLTLPPLATVWLRPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JPP3</accession>
    <name>A0A2M9JPP3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GNAT family N-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_26935</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000012">
        <property type="protein sequence ID" value="PJN08815.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08815">
        <property type="protein sequence ID" value="PJN08815"/>
        <property type="gene ID" value="CG723_26935"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="23"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN08815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="191" mass="21345" checksum="D0D2398C36CB1947" modified="2018-04-25" version="1">MQYPVPRSAGYGEVLSVTESTEVLVRPGAETDLDALTALYNHYVRETPITFDTAVFTPQERRPWLLSHLEDGRHLLLVAQERDSGRVLGYATSGPFRAKAAYDTSVEVSVYCAPDAGGRGIGTLLYKALFEALAGEDVHRAYAGITQPNEASDRLHTRFGFTYVGTYREVGRKFGRYWDVAWYERPVNSDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JQG1</accession>
    <name>A0A2M9JQG1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Enamine deaminase RidA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CG723_24645</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000010">
        <property type="protein sequence ID" value="PJN09108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN09108">
        <property type="protein sequence ID" value="PJN09108"/>
        <property type="gene ID" value="CG723_24645"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035959">
        <property type="entry name" value="RutC-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006175">
        <property type="entry name" value="YjgF/YER057c/UK114"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11803">
        <property type="entry name" value="PTHR11803"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01042">
        <property type="entry name" value="Ribonuc_L-PSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55298">
        <property type="entry name" value="SSF55298"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PJN09108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="140" mass="15628" checksum="88567F672FEBB967" modified="2018-04-25" version="1">MTTHRRIRPFNTADTYPEQDLSNDLAQAVVADGTVYLRGQIGQDLDTRENVGVGDVAAQAEKAMANIAMLLEESGSRLEDIVKVTVYLTDIRFREPVYRVMGRRLKGVHYVSTGLVVSALARPEWLVEIDATAVIPKERR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JQY9</accession>
    <name>A0A2M9JQY9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_23395</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000009">
        <property type="protein sequence ID" value="PJN09299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN09299">
        <property type="protein sequence ID" value="PJN09299"/>
        <property type="gene ID" value="CG723_23395"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN09299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="290" mass="29651" checksum="39CED0367D424825" modified="2018-04-25" version="1">MSSDTRQSRDTRQSRDAQQGRDPRQGPDAQQGGFAGKVAMVTGAGSGMGAAVARQLAAEGARAVVLADVNSENAGTVAKGLSVGRAVALDVADAPAVDAAVADIVREHGRLDVVVHAAGVDDPEAKELIADALVDGRPAEVTDRLTDAAWGRVMRINLDGTFHVLRAAVRVMRPRKAGAIVVIGSSSAFDTPVGYPHYAASKAGVHALTQAVAKEVVASGIRVNVVAPGPTETGMAARTPAVLRSGFADPRVRPYATPEEIADIALFLAGDAAANLVGAVLLANGGRFTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JR49</accession>
    <name>A0A2M9JR49_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Glucose-6-phosphate 1-dehydrogenase</fullName>
            <shortName evidence="5">G6PD</shortName>
            <ecNumber evidence="5">1.1.1.49</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5 9" type="primary">zwf</name>
        <name evidence="9" type="ORF">CG723_23550</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CB01635</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the oxidation of glucose 6-phosphate to 6-phosphogluconolactone.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>D-glucose 6-phosphate + NADP(+) = 6-phospho-D-glucono-1,5-lactone + H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:15841"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:57955"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:61548"/>
            <dbReference type="EC" id="1.1.1.49"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="5">Carbohydrate degradation; pentose phosphate pathway; D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage): step 1/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the glucose-6-phosphate dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.49" evidence="5"/>
    <dbReference type="EMBL" id="NNBL01000009">
        <property type="protein sequence ID" value="PJN09324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN09324">
        <property type="protein sequence ID" value="PJN09324"/>
        <property type="gene ID" value="CG723_23550"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00115">
        <property type="reaction ID" value="UER00408"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004345">
        <property type="term" value="F:glucose-6-phosphate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006006">
        <property type="term" value="P:glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006098">
        <property type="term" value="P:pentose-phosphate shunt"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00966">
        <property type="entry name" value="G6PD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001282">
        <property type="entry name" value="G6P_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019796">
        <property type="entry name" value="G6P_DH_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022675">
        <property type="entry name" value="G6P_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022674">
        <property type="entry name" value="G6P_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23429">
        <property type="entry name" value="PTHR23429"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02781">
        <property type="entry name" value="G6PD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00479">
        <property type="entry name" value="G6PD_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000110">
        <property type="entry name" value="G6PD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00079">
        <property type="entry name" value="G6PDHDRGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00871">
        <property type="entry name" value="zwf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00069">
        <property type="entry name" value="G6P_DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="1 5" id="KW-0313">Glucose metabolism</keyword>
    <keyword evidence="2 5" id="KW-0521">NADP</keyword>
    <keyword evidence="3 5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="G6PD_N" evidence="7">
        <location>
            <begin position="14"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="domain" description="G6PD_C" evidence="8">
        <location>
            <begin position="186"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="5">
        <location>
            <position position="235"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="49"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="143"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="173"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5 6">
        <location>
            <position position="177"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="211"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="230"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="321"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022526"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PJN09324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="469" mass="52785" checksum="97634DCFC5721301" modified="2018-04-25" version="1">MASNSPNVPADVLVIFGISGDLARKMTFRSLYRLERRKLLTCPIVGVARDGWSDDALRDHARAAIKATGEPLDDSVFARFAARLSYVQGDYADPETFHRLARAVNGKRHPVFYLETPPSLFARVVEGLAGVGLTKGARVVVEKPFGHDLASARALNAELRQLLDEDQLLRIDHFLGKEPAMDIQFLRFANSVFEPVWNRDHVSCVQITMAEDFGVEDRGHFYDPVGALRDVVQNHLLQLLALMASEPPSAADADALRDRRVDVFRAIPDADPAHYVRGQYEGYLQVPGVRPRSRTETFVGLRLEVENWRWSGVPFFIRAGKSLPERVTEIRIVFKRPPRLAFAERFAPEPDQWILRIDPSPGVNFRIQAKQPGKQDTQLVDLDLLFAAELGEAPEPYERLLSDAMQGNASLFTREDSVEETWRIVQPLLEAPGDPERYRPGTWGPEGASKLVAGYPRWHEPWLPARSPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JR64</accession>
    <name>A0A2M9JR64_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Peptidase_M48 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CG723_23770</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CB01635</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000009">
        <property type="protein sequence ID" value="PJN09353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN09353">
        <property type="protein sequence ID" value="PJN09353"/>
        <property type="gene ID" value="CG723_23770"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001915">
        <property type="entry name" value="Peptidase_M48"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01435">
        <property type="entry name" value="Peptidase_M48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="23"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="101"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="226"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="259"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="342"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="383"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="414"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="444"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="483"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="549"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="599"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="633"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="665"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="719"/>
            <end position="741"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="769"/>
            <end position="789"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M48" evidence="8">
        <location>
            <begin position="137"/>
            <end position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PJN09353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="967" mass="104045" checksum="8D1EF8CF14ED135B" modified="2018-04-25" version="1">MSTPDLRRPFDERAIGAGTTPRFVLLVILLLVSSGSMMISVSFSSLSETDSNSMGCMLAAGVDLNRIDDMASSIGGVLHADALETCLARYAPEPAPDPLGLLWPGLVLAASALVFRALPAWKAWRGRHVPLEDVDRTGAIRSTLDEVAAQSGLARTPRFVVAPTALSAGAAVYGSNQRPTVCLHAGLLARRTGDPEGFRAVLLHEFAHVRNGDVTLTYATVALWRVFLALVLLPYLVWCVAALTTSFQSPIRHAEQMTVGRAFILPVFLTVLVYLARADVLRMREVYADLAAVSGGADPRGWAVPVPPGPESRLRRGWARFSEVWRTHPRWDLRRGALEDPAMLFGVQALLMLLTGIAAPVITNQAGTVLGGGSGWRAYLVPLLGAAAVTGVAGIALWRAVAHAVLTERRVLSGVRAGLWLGAGMAVGAVVTPQMSPTRWLPPHAEVLAAVVAAGVLFAWWITESSQLWLRAWPRQVRGPAMLLVMGVGCLLLTAWIVWWQTFGTGLVGGWFDMDASRRETELTFPGPIAEHQGMVFALSVWFEVFTGFQQPIVLAAVCALCVVPLLAWTTGQGRREGQASGGSTADDSRPALPPLRPVLLAAILGGLACWGGIAVAKAYMHTWQPETGERGGLYSVSLSAWVLVVLVAISATTGALIANRLGCYPFYSTLLTAEITALTGLSGYYLLMSVDGCIQPLSTLSSQCHWVPYPAWMVTRVLLAPVLISTALVVTIAGTAVLAFQRLRGSDQGRSASVRQPESRRRLYARRAAVAAICAITVSATVTASAAVSREGTSGDGVEKRNHAYSQVPRASASTPVIRRAQLEYWLKFGGGDLLNRFGDAHKALGDAFIKGADAGGTIKESEFDPICRQFGLIAKDAGKYFPIPDARADAQWQKHNALMQKAAKSCSHSFDHGEEQEFNKSMDNFHETAVFIDAMGRRFDEIREAAPTSALRSSAWRRPPVFEPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JRG0</accession>
    <name>A0A2M9JRG0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_23790</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000009">
        <property type="protein sequence ID" value="PJN09432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN09432">
        <property type="protein sequence ID" value="PJN09432"/>
        <property type="gene ID" value="CG723_23790"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="44"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN09432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="66" mass="7542" checksum="8A5A927E26EA2035" modified="2018-04-25" version="1">MGRPDRPQPSDRRYFALNGTDHRSHEEQNAAIGAYVRWRNAHAKPKTHFAPDSPIRSRTDYPAKAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JRK1</accession>
    <name>A0A2M9JRK1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">2-nitropropane dioxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_22370</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000008">
        <property type="protein sequence ID" value="PJN09506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN09506">
        <property type="protein sequence ID" value="PJN09506"/>
        <property type="gene ID" value="CG723_22370"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018580">
        <property type="term" value="F:nitronate monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04730">
        <property type="entry name" value="NPD_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004136">
        <property type="entry name" value="NMO"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03060">
        <property type="entry name" value="NMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014754215" evidence="1">
        <location>
            <begin position="25"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="domain" description="NMO" evidence="2">
        <location>
            <begin position="3"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN09506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="320" mass="34034" checksum="EDDE906D59452973" modified="2018-04-25" version="1">MFGLRYPVMAAPMSLHSGGTLAAAVSAAGGLGSFGGTHPWKGPDWIREQIATIRATMDRPFGVGFITPFLPFSEPHFDAALEERPEIIALSFANPQPWLARAKDAGARVMCQVQTYDDAETAVAAGTDVLVAQGTEAGGHTGTMGLLPFLAGIVRRYPGVPVLAAGGIGDGRTLAAVLTAGADGAWLGTAFLATPEAVEVHDVHKRLIVDSDGGDTVWTRAYDIASGLPWPATIGTRVRRNRFTDEWSGREAMLRDRKEEFAPAEDINPFEAPPDPDTSEILYGQSATFVDAVRPAADVVRTISDEAEAILASRPRSLLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JRN0</accession>
    <name>A0A2M9JRN0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_22470</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000008">
        <property type="protein sequence ID" value="PJN09514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN09514">
        <property type="protein sequence ID" value="PJN09514"/>
        <property type="gene ID" value="CG723_22470"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN09514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="68" mass="7102" checksum="7D3B107FF2F2B459" modified="2018-04-25" version="1">MARTFAGSARVRATAEVVGWWAVLTGLWLVLISRVDLLEWVVGSCASLLAAFGARAARLAATGRNGSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JRN9</accession>
    <name>A0A2M9JRN9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CG723_22630</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000008">
        <property type="protein sequence ID" value="PJN09541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN09541">
        <property type="protein sequence ID" value="PJN09541"/>
        <property type="gene ID" value="CG723_22630"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PJN09541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="79" mass="8412" checksum="A16ECE6599FE0EFA" modified="2018-04-25" version="1">MVALDGCLPSGCFWRILPPMARPALGTVSVRAVAGSRRAFVLTMARSAYAQTCHRAGDVPALELLECLRSPSARWPNGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JS14</accession>
    <name>A0A2M9JS14_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Dihydrofolate reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CG723_20755</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CB01635</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000007">
        <property type="protein sequence ID" value="PJN09648.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN09648">
        <property type="protein sequence ID" value="PJN09648"/>
        <property type="gene ID" value="CG723_20755"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006139">
        <property type="entry name" value="D-isomer_2_OHA_DH_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029753">
        <property type="entry name" value="D-isomer_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006140">
        <property type="entry name" value="D-isomer_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00389">
        <property type="entry name" value="2-Hacid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02826">
        <property type="entry name" value="2-Hacid_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00671">
        <property type="entry name" value="D_2_HYDROXYACID_DH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="2-Hacid_dh" evidence="3">
        <location>
            <begin position="63"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="domain" description="2-Hacid_dh_C" evidence="4">
        <location>
            <begin position="109"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PJN09648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="316" mass="33522" checksum="1BDB615F5F7C5727" modified="2018-04-25" version="1">MSAEVSADVWLPFREDEVPGLPEGLNYRFWDGGPDFPADPADCAFYVVPYMKGADVGVRPMVEMTSVRAVQTLSAGIDHVQGGLKSLPSGVRLCNARGVHEASTAELTLALILASLRGIPGFVRGQESEEWRSGFYPALADKIVLIIGYGSIGSAIEDRLAPFECARVVRVARSARTTARGPVHPLTELPALLPDADVVILSTPLNEATRGLADAGFLARLKDGALLVNVARGAVVDTEALLAELESGRITAALDVTDPEPLPQGHPLWHAPGVLVSPHVGGSTSAFWPRAKRLLAAQLTRFAAGEPLENVVLTTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JSG7</accession>
    <name>A0A2M9JSG7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_21740</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000007">
        <property type="protein sequence ID" value="PJN09819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN09819">
        <property type="protein sequence ID" value="PJN09819"/>
        <property type="gene ID" value="CG723_21740"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="110"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN09819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="431" mass="44390" checksum="E600783113ED56E4" modified="2018-04-25" version="1">MAATLGSTDDPKDLIPGEAGKLGDIETAFNGWSDKFEKIGDGLRDLRIKGWVGQASEAFWPTLGKEKTNWYFASDAMSGASKAVHSYVSTLTWAQGQAGTAIDKWKAGDHEGAEALLKGAQKQLKEEAEKLTKKLHDLAGDSKDSPGWLTAIRSGVDAKKWLEDHGVGKSAIAPEAWQRENKRWFGTRENPRHREKEWGKGEDGKWYFRDKTAAAGADDEGTPPKKAEVSIKIAEWSGKASVWSDGIDGDGKWGDAKYKYAAGAQALGVDGSAGLSVTDGRFKAGVSGTAYLAQASANGSVEYGVAAVQGEAKAFVGADASANVSAGKDGVHGGAEAFAGAKATGSASADVAGIGAGATGEAWAGVGAEAHADLGMKDGKFTIGGDAGVGLGLGGKVGFNVTVDTGKLTGALSDGADAVGDVWDSTVGGWF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JSM5</accession>
    <name>A0A2M9JSM5_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase (flavodoxin)</fullName>
            <ecNumber evidence="4">1.17.7.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">ispG</name>
        <name evidence="5" type="ORF">CG723_21570</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CB01635</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>(2E)-4-hydroxy-3-methylbut-2-enyl diphosphate + 2 H(+) + H2O + oxidized [flavodoxin] = 2-C-methyl-D-erythritol 2,4-cyclic diphosphate + reduced [flavodoxin]</text>
            <dbReference type="Rhea" id="RHEA:43604"/>
            <dbReference type="Rhea" id="RHEA-COMP:10622"/>
            <dbReference type="Rhea" id="RHEA-COMP:10623"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57618"/>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
            <dbReference type="ChEBI" id="CHEBI:58483"/>
            <dbReference type="ChEBI" id="CHEBI:128753"/>
            <dbReference type="EC" id="1.17.7.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="4">Binds 1 [4Fe-4S] cluster.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4">Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via DXP pathway; isopentenyl diphosphate from 1-deoxy-D-xylulose 5-phosphate: step 5/6.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the IspG family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.17.7.3" evidence="4"/>
    <dbReference type="EMBL" id="NNBL01000007">
        <property type="protein sequence ID" value="PJN09787.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN09787">
        <property type="protein sequence ID" value="PJN09787"/>
        <property type="gene ID" value="CG723_21570"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00056">
        <property type="reaction ID" value="UER00096"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046429">
        <property type="term" value="F:4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019288">
        <property type="term" value="P:isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016114">
        <property type="term" value="P:terpenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.413.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00159">
        <property type="entry name" value="IspG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011005">
        <property type="entry name" value="Dihydropteroate_synth-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016425">
        <property type="entry name" value="IspG_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004588">
        <property type="entry name" value="IspG_bac-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045854">
        <property type="entry name" value="NO2/SO3_Rdtase_4Fe4S_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30454">
        <property type="entry name" value="PTHR30454"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04551">
        <property type="entry name" value="GcpE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004640">
        <property type="entry name" value="IspG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51717">
        <property type="entry name" value="SSF51717"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56014">
        <property type="entry name" value="SSF56014"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00612">
        <property type="entry name" value="ispG_gcpE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="3 4" id="KW-0414">Isoprene biosynthesis</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="4">
        <location>
            <position position="280"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="283"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="315"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="322"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PJN09787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="385" mass="40567" checksum="1E9DCD18245C65FF" modified="2018-04-25" version="1">MTAISLGMPSVPTKLAERRRSRQIQVGTVAVGGDAPVSVQSMTTTRTSDIGATLQQIAELTASGCQIVRVACPTQDDADALATIARKSQIPVIADIHFQPKYVFAAIEAGCAAVRVNPGNIKQFDDKVKEIAQAAKDHGTPIRIGVNAGSLDARLLKKYGKATPEALVESALWEASLFEEHGFRDIKISVKHNDPVVMVNAYRQLAAQCDYPLHLGVTEAGPAFQGTIKSAVAFGALLSEGIGDTIRVSLSAPPVEEIKVGNQILESLNLKPRRLEIVSCPSCGRAQVDVYKLAEEVTAGLDGMEVPLRVAVMGCVVNGPGEAREADLGVASGNGKGQIFVKGEVIKTVPESKIVETLIEEALKIAEQMELDGVASGEPTVAVAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JSW7</accession>
    <name>A0A2M9JSW7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Protein kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_19755</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000006">
        <property type="protein sequence ID" value="PJN09965.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN09965">
        <property type="protein sequence ID" value="PJN09965"/>
        <property type="gene ID" value="CG723_19755"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023346">
        <property type="entry name" value="Lysozyme-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53955">
        <property type="entry name" value="SSF53955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="1">
        <location>
            <begin position="19"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN09965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="516" mass="56580" checksum="466C0B8D4F737755" modified="2018-04-25" version="1">MTDQPYTVEVPAGYRVGPWVVREPLAAGAFGSVYAASLRNADAAASDGTDRLPKTAALKFLPTGTRTPRQLNHLRELAEREVELLSRLRSPRLIRLYDTVTIDDPDRPALDGVTVLVLERAEGSLADLLARPEPPASGPALLAQICEGLHQLHQAGWVHGDLKPANVLLMKDGSARLADFNMAAELEGTHAYAPAFATPDYTPPELLWAEIGERGQQIRPTADVWAYGVLAHLVLTGTYPLPGGMPSARRDAAVRYTRGTEELRLSPELPDSWREIIADCLTRTHEERAAHDSGTVLRRVESVVGTGRSPRLPRLRPRRVRPRVAVVTALAAALLGTGAALTLYDGGNDPATYGSAELRTDKGVPVAYRRSIVDAAHGCNDKNVTPAMIAALLKVESDFDPDLADPAKNEYGIARWTPDILWYWIDTDRRTKLIKDLKPPFPPDVSIRAVGRYTCEISRRLKEPAELPGNRGVLIATGYVTSAERVNTSEGVPEKYRDFAARIEHYLKEYTAHGDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JT93</accession>
    <name>A0A2M9JT93_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Adenosine deaminase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CG723_20490</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CB01635</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000006">
        <property type="protein sequence ID" value="PJN10089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN10089">
        <property type="protein sequence ID" value="PJN10089"/>
        <property type="gene ID" value="CG723_20490"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019239">
        <property type="term" value="F:deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009168">
        <property type="term" value="P:purine ribonucleoside monophosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01320">
        <property type="entry name" value="ADA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006650">
        <property type="entry name" value="A/AMP_deam_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001365">
        <property type="entry name" value="A_deaminase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006330">
        <property type="entry name" value="Ado/ade_deaminase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43114">
        <property type="entry name" value="PTHR43114"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00962">
        <property type="entry name" value="A_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01430">
        <property type="entry name" value="aden_deam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00485">
        <property type="entry name" value="A_DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="A_deaminase" evidence="3">
        <location>
            <begin position="12"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PJN10089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="342" mass="37517" checksum="E7D9BF4167838BFD" modified="2018-04-25" version="1">MERVPRDVRQLPKAHLHLHFTGSMRPTTLLELADKYGVRLPDALTGSEPPKLRATDERGWFRFQRLYDAARSCLREPEDIQRLVREAALEDLADGSGWLEIQVDPTSYAPRLGGLIPALEVILDAVETASRDTGLGMRVLVAANRMKHPLDARTLARLAVRYADRGIVGFGLSNDERRGMARDFDRAFAIAREGGLLAAPHGGELTGPASVRDCLDDLEATRIGHGVRAAEDPRLLKRLADRQVTCEVCPASNVALGVYEKPEDVPLRTLFEAGVPMALGADDPLLFGSRLAAQYEIARRHHDFDDAELAELARQSVRGSAAPQDIKAKLLSGVDDWLTAAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JTA8</accession>
    <name>A0A2M9JTA8_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5">30S ribosomal protein S19</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">rpsS</name>
        <name evidence="8" type="ORF">CG723_20310</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CB01635</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5 6">Belongs to the universal ribosomal protein uS19 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000006">
        <property type="protein sequence ID" value="PJN10062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN10062">
        <property type="protein sequence ID" value="PJN10062"/>
        <property type="gene ID" value="CG723_20310"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.860.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00531">
        <property type="entry name" value="Ribosomal_S19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020934">
        <property type="entry name" value="Ribosomal_S15/S19_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002222">
        <property type="entry name" value="Ribosomal_S19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005732">
        <property type="entry name" value="Ribosomal_S19_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023575">
        <property type="entry name" value="Ribosomal_S19_S15_SF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11880">
        <property type="entry name" value="PTHR11880"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00203">
        <property type="entry name" value="Ribosomal_S19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002144">
        <property type="entry name" value="Ribosomal_S19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00975">
        <property type="entry name" value="RIBOSOMALS19"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54570">
        <property type="entry name" value="SSF54570"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01050">
        <property type="entry name" value="rpsS_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00323">
        <property type="entry name" value="RIBOSOMAL_S19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 5 6" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0699">rRNA-binding</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="74"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00015696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PJN10062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="93" mass="10599" checksum="7AD280F47D12A787" modified="2018-04-25" version="1">MPRSLKKGPFVDDHLVKKVDVQNEAGTKNVIKTWSRRSMIIPSMLGHTIAVHNGKIHIPVFVTESMVGHKLGEFSPTRTFRGHVKDDRKSKRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JTL2</accession>
    <name>A0A2M9JTL2_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">APH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_17680</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000005">
        <property type="protein sequence ID" value="PJN10226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN10226">
        <property type="protein sequence ID" value="PJN10226"/>
        <property type="gene ID" value="CG723_17680"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="APH" evidence="2">
        <location>
            <begin position="42"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN10226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="307" mass="33408" checksum="EBE76C335BD7A753" modified="2018-04-25" version="1">MRLAQEGSVPRNTTSDEADTRTARAVLREANHAHDKQFQLLHRFDDGVQSGAWLLTDGTGRQAVLKWSPDLSWAPQIERAAAGVAKIRAAGYPTPAWLAVGTSTDGFGYQIQELAPGRTRQQVTASEARLLIGVLELHAGLDPDPQRCWSEFVTTRMTSEDLWRQTAQTGATGRDLVNACERLLAAHGPVTLPTEDLVHGDFRPGNLLFDADRVSGVIDIEALGSGTRVFDYATLLSAHDFTPEALEMLCDAGEQVAGPGVLAYCFAQVALDLTVFVHQRNLRLGIQNVDKLLERTLILLSRADGEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JTT4</accession>
    <name>A0A2M9JTT4_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HTH luxR-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_17515</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000005">
        <property type="protein sequence ID" value="PJN10197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN10197">
        <property type="protein sequence ID" value="PJN10197"/>
        <property type="gene ID" value="CG723_17515"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002831">
        <property type="entry name" value="Tscrpt_reg_TrmB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01978">
        <property type="entry name" value="TrmB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH luxR-type" evidence="2">
        <location>
            <begin position="253"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00421"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN10197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="316" mass="34559" checksum="749149377610C1DB" modified="2018-04-25" version="1">MPQLTAAGIEAFDESVYRAILVRHTAAPADLAGDLSCSTERVARALDRLRENGLVGRLAGTRRRYAAIEPGAALESLVRSRTADLDGVRAAAGELSRLFAAARQGGSEQVEVITGGEALGRWFVQLQQEARDEVITLDRPPYALTTSNPVEATALTRGVRYRAVYAPEALEWPGVLGDIRELVAHGEQARVLPGLRIKLAISDRRLALMPLSLDFTTEVRAAVIRPSALLDGLIDYWELCWRTATPLGAPAEEDPLGEEDRQMLTLLVGGLKDEAIARQLGWSVRTMRRRISRLHEELGAANRFQAGVIAARRGWI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JTT8</accession>
    <name>A0A2M9JTT8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Sugar kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_18110</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ROK (NagC/XylR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000005">
        <property type="protein sequence ID" value="PJN10300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN10300">
        <property type="protein sequence ID" value="PJN10300"/>
        <property type="gene ID" value="CG723_18110"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000600">
        <property type="entry name" value="ROK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18964">
        <property type="entry name" value="PTHR18964"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00480">
        <property type="entry name" value="ROK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN10300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="427" mass="44812" checksum="21F1B3B6B86B8DB3" modified="2018-04-25" version="1">MDRRSRRTVSDLRRANRAVILQQLYFDGPTSRQALGPLTGLSSGSVSNVVAELAADGLVEEAGSLDSDGGRPRILLRVSPHSGNLIGIDVGETRVRVEVFDVTLTELARADIPLTGDGYDVAVVVEHIRSGIEQVLAEAGVPADDLLGIGIGVPGVVERVPESGAVVHCQTIGWDAVPLEALLRASSQLPSTVPYFIDNGAKTLGQAEMWFGAGRGARSAAIVLFGTGVGACLFADGRGRALEWGHLTVQAGGRTCRCGAPGCLEAYAGAESVLERWREAGGQPPQGADEETQLTALLAAACPTDGTDPDPVAYEVMAKTAEYLGAGLSDLINLFQPERILIGGWAGLQFGSRFLDDVRKHSTKYALSYPAGKATIELGKLGPDAVTVGAATLPLEDFFARGGRRDAPAREPTPPAWRTALEGRVLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JU50</accession>
    <name>A0A2M9JU50_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">TetR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CG723_18800</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000005">
        <property type="protein sequence ID" value="PJN10410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN10410">
        <property type="protein sequence ID" value="PJN10410"/>
        <property type="gene ID" value="CG723_18800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025996">
        <property type="entry name" value="TetR_C_WHG"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13305">
        <property type="entry name" value="TetR_C_33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="5">
        <location>
            <begin position="14"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="4">
        <location>
            <begin position="37"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PJN10410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="240" mass="25116" checksum="36AC671EF4EE17D2" modified="2018-04-25" version="1">MAETARTPRARYREQTRAEIKDIALAQLAEGGTAAVALTRIAKQVGLSGPALYRYFDSRDALLTELIRDAYADLAAAVTAVAGTWPAKAPTARARLHGLADACRSWATEQPHRYLLIQGTPVPGYTAPADTLDSARAVLGPFLTAFEGARPSEVAQSLVEEMTAWAGRDTSVAEWVQQHAGESAHGEEAGTALAGAVLAWSHLHGAISLEVSGQFAGMGHGGGTLLAAQIDMLADAFGLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JUB1</accession>
    <name>A0A2M9JUB1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Spermidine/putrescine ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CG723_18525</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000005">
        <property type="protein sequence ID" value="PJN10367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN10367">
        <property type="protein sequence ID" value="PJN10367"/>
        <property type="gene ID" value="CG723_18525"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008995">
        <property type="entry name" value="Mo/tungstate-bd_C_term_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013611">
        <property type="entry name" value="Transp-assoc_OB_typ2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08402">
        <property type="entry name" value="TOBE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50331">
        <property type="entry name" value="SSF50331"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="6"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="38"/>
            <end position="45"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PJN10367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="344" mass="37517" checksum="835F0D205095025A" modified="2018-04-25" version="1">MEGMAIRLQSLRKSFGRTEAVAGVDLEIADGEFFSMLGPSGSGKTTVLRMIAGFEAPTAGTIELAGADVTRRAPFERDVHTVFQDYALFPHMTLEQNVAYSLKVRKVPKAERLARAREALASVQLEGFGGRRPSQLSGGQRQRVALARALVGRPKVLLLDEPLGALDLKLREQMQVELKAIQREIGITFVFVTHDQEEALTMSDRIAVFNQGRVEQVGTPAQIYERPATPFVAGFVGTSNLLSGDAAEQVVGDRGTYSIRPEKIHVLKESAAAEPEHASATGTVAEVVYLGDATRFLVDLDAGGRLTALQQNLETSSEDVAALRGSRVRLQWHRRHNFQVPEAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JUK4</accession>
    <name>A0A2M9JUK4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Glycine/betaine ABC transporter substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CG723_15235</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000004">
        <property type="protein sequence ID" value="PJN10571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN10571">
        <property type="protein sequence ID" value="PJN10571"/>
        <property type="gene ID" value="CG723_15235"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007210">
        <property type="entry name" value="ABC_Gly_betaine_transp_sub-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04069">
        <property type="entry name" value="OpuAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014955086" evidence="2">
        <location>
            <begin position="27"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="domain" description="OpuAC" evidence="3">
        <location>
            <begin position="48"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PJN10571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="322" mass="34627" checksum="039BA252B1C3CB2A" modified="2018-04-25" version="1">MRRTYRAAAAAGLVASLLAGCGLTSGSPLVDDVKPGSIGKGEPLKGANITVTSKEFTEQLILGAMMGIAFKAAGADVLDRTGIQGSIGAREAIKSGDADGMYEYTGTAWITYLGNSHPIPDPQKQWQAVHDADLKNGITWLPPSELNNTYALAMNEANFKKYGTKTLSDVAALARKNPKAVTLCVESEFANRADGLHGMEKAYGMKIPTANVTQMDTGIIYTQAAKGTCTFGEVFTTDGRIRAMKLRVMADDKHFFPNYNAAPEMNTKSLEKYPAMATVIEPITKKLNNTVAQELNARVDVDGQDPHSVAKDWLVKEGFVTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JV15</accession>
    <name>A0A2M9JV15_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_15885</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000004">
        <property type="protein sequence ID" value="PJN10682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN10682">
        <property type="protein sequence ID" value="PJN10682"/>
        <property type="gene ID" value="CG723_15885"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="486"/>
            <end position="532"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN10682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="532" mass="57969" checksum="432D8110B17426C6" modified="2018-04-25" version="1">MPLINDLARLEAVQSGRAQPVATVRHRHLSQRPLVLVPLITAGEAGAPLGALVGTERTSPRLLVVPQPRDRDLRFAFLAELAGIVLPYVDGFAADVEAAERAETDPTTGKRAKVEVELCADAPQLILPSRSGIEFVRLLGRSMRFRRTAEQEPEAPYPAPPHVPLLGRWLTHFGERARVPGSALLLAMTDLLSRHWATGQSTLEDQHLGALLAWIEAPEGTSGAEAALRAELARDKDGQLVCPPAGPATDPAFDNKLLAPAIEHYDKARTLLAAAEDGIEADARLAALTAAERDIHALVESRTRPTWDAVWRGLDTLCTLPEGPRAAERWTRDRWSFTGHRDRVAAGEPPQPRRDDAVTAANKLATREREQARLDAQEALDDPLVMAGRRLTGEAFAGEVTESVPAYNEKNRPRPLITVRTDDVPHLGERTKVYRSLDGKPQAAEFVSYDAEGGVVLRVLDKMGRGKEPEPGSVPEKGDQVCFTLFEHEQRGGPKLPDPEETPWTHGGPPRTDRSGVPVPEAPDAVTTEDLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JVR2</accession>
    <name>A0A2M9JVR2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CG723_15350</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000004">
        <property type="protein sequence ID" value="PJN10918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN10918">
        <property type="protein sequence ID" value="PJN10918"/>
        <property type="gene ID" value="CG723_15350"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PJN10918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="50" mass="5485" checksum="0F2E321EA424D6E6" modified="2018-04-25" version="1">MRSHSGIPDGNRYDDPMVLHDVSDKTPGMLLVARLHVDLCRLASAICPNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-06-02" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JVS2</accession>
    <name>A0A2M9JVS2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_08315</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN10996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN10996">
        <property type="protein sequence ID" value="PJN10996"/>
        <property type="gene ID" value="CG723_08315"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="24"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN10996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="129" mass="13610" checksum="0D810BE1E86721D8" modified="2018-04-25" version="1">MAEQPKSQPSHGEGPGPHKGTKQHGWSPDVDETRQQDNPSAHRSFHPDQHAPAKGPGREVSKDEAGNTHGKPVKSRGRRGEDQSKAGSDEKGMHDTGPRGRSQRPSGTKDASASTGVDPKDPPGTRSAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JW16</accession>
    <name>A0A2M9JW16_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Serine/threonine protein phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_08510</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN11022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN11022">
        <property type="protein sequence ID" value="PJN11022"/>
        <property type="gene ID" value="CG723_08510"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07228">
        <property type="entry name" value="SpoIIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00331">
        <property type="entry name" value="PP2C_SIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="SSF81606"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPM-type phosphatase" evidence="2">
        <location>
            <begin position="245"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN11022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="477" mass="52138" checksum="8F229DB7B1BEFE81" modified="2018-04-25" version="1">MLSRTDEKPFPGVLGHVRQKPRSPGHFPGRTANPGTAESPKSHDESSPRARARRPGVRLHRYASAVDRTRFRRRGDEVSVPEIPDVALGELLADPGTSTLDLTTAVARCSKALGLEHSVVYLADLQQRQLTPLNDVLPALPIDDSLAGWTYRTQSLRVEESDVGGMTAWLPLVDGAERLGVLAVRSPALDPLSLRRGRTLAALLAMMVTSKKAYKDTYVRQTRTEPMRLAAEMLRAYLPPRTIGSTRVVSTAVLEPAYEIGGDAFDHALTDSILHTAILDAMGHDLASGLTSVVALAACRHARRNGADLPDLVESVDTALSEWLPNRFCTSVLAQLDLRTGKLRWINCGHPAPLLIRDQRLVAGAMDREADPPMGMPAAFTVEPRRVHEISLEPGDRVLMFTDGVTEARTGDGGELGLERFADYVVRAAATGELAPETLRRLIHAILDAQENRLRDDATILMLEWRNPPRAPEAYGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JW50</accession>
    <name>A0A2M9JW50_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_09245</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN11135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN11135">
        <property type="protein sequence ID" value="PJN11135"/>
        <property type="gene ID" value="CG723_09245"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043917">
        <property type="entry name" value="DUF5753"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19054">
        <property type="entry name" value="DUF5753"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="22"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN11135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="288" mass="32550" checksum="60392C12819B8A4F" modified="2018-04-25" version="1">MSEARSSTSAPTVLRMILGRRLQDMRLGAGASLEDAAKALRVKTLTIRRLEKAEVALKPLYVEKLLETFGADRQEIDEFVDLAERANEPGWWHSYRDAVPSWFTAYVSLETDAKTLRTYEPQYVTGLLQTPDYARAVLRGGLPNGSEEELARRVELRLRRQSLLEGEDAPTLWVVMEEAVLHRAVGSSDVMREQIERLLDVSELEHISIDIVPFAAGAHVGACAPFTYFRFEEPELPDIVYSELLSASVYLDQRVDVVAHLEAHSRMALLTSSEDSRALLNRMRKEYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JW77</accession>
    <name>A0A2M9JW77_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Benzoylformate decarboxylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CG723_08885</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CB01635</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the TPP enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN11078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN11078">
        <property type="protein sequence ID" value="PJN11078"/>
        <property type="gene ID" value="CG723_08885"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030976">
        <property type="term" value="F:thiamine pyrophosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012000">
        <property type="entry name" value="Thiamin_PyroP_enz_cen_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012001">
        <property type="entry name" value="Thiamin_PyroP_enz_TPP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045229">
        <property type="entry name" value="TPP_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011766">
        <property type="entry name" value="TPP_enzyme-bd_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18968">
        <property type="entry name" value="PTHR18968"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02775">
        <property type="entry name" value="TPP_enzyme_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00205">
        <property type="entry name" value="TPP_enzyme_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02776">
        <property type="entry name" value="TPP_enzyme_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="SSF52467"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0786">Thiamine pyrophosphate</keyword>
    <feature type="domain" description="TPP_enzyme_N" evidence="6">
        <location>
            <begin position="6"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="domain" description="TPP_enzyme_M" evidence="4">
        <location>
            <begin position="191"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="domain" description="TPP_enzyme_C" evidence="5">
        <location>
            <begin position="383"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="334"/>
            <end position="354"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU362132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PJN11078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="536" mass="57553" checksum="22C61472E8AA7C56" modified="2018-04-25" version="1">MTEQSTVRSVTYDLLRALKLTTVFGNPGSTEQPFLQDFPDDFTYVLALQEASVVAMADTFAQVTGRPALVNVHSSAGLGNAVGNLVAAYHGNTPLIITSGQQHRDLLIGEPYLGNREAITLPKPWVKWSYEPARAEDVPEAFMRAYAEALQPPTGPVYLSIPMGDWKEPLSDFTRVRTVSDRVAPSTERLRAFADRVSASSRPALVFGPEVDRAGGWEAAVALAEKLRASVYGAPLLDRASFPEDHPLFRGPLGMSVKTISDRLTGHDLVVVIGAEVFRYYPYVPGDYLPDGTELLQITGNPAVAAAARVGDSLLGDPAIAIELLLDMVTEGSTRTAPEPMARPRELPQEPNSPLTPPEVYATLSEVRPPDAVIVNESTSTMAQQIEWLPTTRTGSFFATASGGIGWGTPAAVGVALGDRDRGVRRPVVGLIGDGSFQYSVQAIWTAAQHNLPIVYVVMHNHEYSILKSFAVLEETPGVPGLDLPGLDIASVARGFGCNAVDVETTQDLEREFKAALAAGTTTVIVVPTQPQKAML</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JWC3</accession>
    <name>A0A2M9JWC3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CG723_08670</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN11047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN11047">
        <property type="protein sequence ID" value="PJN11047"/>
        <property type="gene ID" value="CG723_08670"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PJN11047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="70" mass="7624" checksum="549F480B4B4EB3E4" modified="2018-04-25" version="1">MNNEQLNEESAELLPGREALGRLKFSFVKTTNVTRHVAYVDAHNNSLAANLNSPEAIAASEANQTINISQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JWE2</accession>
    <name>A0A2M9JWE2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">TetR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_09285</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN11142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN11142">
        <property type="protein sequence ID" value="PJN11142"/>
        <property type="gene ID" value="CG723_09285"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023772">
        <property type="entry name" value="DNA-bd_HTH_TetR-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01081">
        <property type="entry name" value="HTH_TETR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="12"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="206"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="35"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="229"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN11142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="387" mass="41903" checksum="5F070FEB6DA7C5CA" modified="2018-04-25" version="1">MTAEPTAATRPRNRRQLIVEAAGRLFSERGYHTASMEEIAAGVGITATALYRHFPNKYALFAECAHVMADRLVGALDETPTEAAPADVLTALIRVTVAHRASGGVYRWEARYLDRDDRRLLRAKFGHVVERVTEAVRREGPLSDEQLRVVAALGAIGSITMHRTSIAQRRLEELLLACALRVIATDPVPAMSSKRSVELPALPVARSRRAEILAAAVPLFARDGFANVTNGQIAQAVGLAPSALYRHYPGKVDILAAACLQAAGLLAQAVDRCLQEVTGPHDAVVALAATYVAYSFEYTALTSVAEAELVGLPADLQRPLVLAQREYIAVWEQQLRLARPELDPRQARVLVHAGFGVVVEAGRRLRWQDSPDHRAAVTSLVAGALGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JWF1</accession>
    <name>A0A2M9JWF1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Peptide ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CG723_09790</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CB01635</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN11225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN11225">
        <property type="protein sequence ID" value="PJN11225"/>
        <property type="gene ID" value="CG723_09790"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="37"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="132"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="177"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="219"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="277"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="326"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="130"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PJN11225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="358" mass="38537" checksum="F1BAA3EDD75EEDA2" modified="2018-04-25" version="1">MTVPALGSVDATAVEPRPGRRLVSARLGTARYFLRRLGFYAVAAALAITLNFLIPRLMPGDPASALIAQMQQKQTLSGDQVHAIYRLFGTPGEPLWDQYVTYLNQVLHFNFGISVAYYPTPVWEVIRTGLPWTVGLVGLTSVLSFVLGTAAGVVSGSRVGSRFDSFMTPASMFMGSLPFFWVALILVLVFGVQLSWLPTGGGYDGDMLPGFNGPFLASVLQHGILPALTMVMASVGGWLVGMRNMMVTTVSEDYVLLARAKGLSKARVMFQYAARNAVLPSVAGFALTIGTVVSGQLLVEIVFAYPGVGYLLYQAVSSVDYPLMQALFLIVSLSVLAANFIADSVYGLIDPRARETRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JWK1</accession>
    <name>A0A2M9JWK1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Methylcrotonoyl-CoA carboxylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_09195</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN11127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN11127">
        <property type="protein sequence ID" value="PJN11127"/>
        <property type="gene ID" value="CG723_09195"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034733">
        <property type="entry name" value="AcCoA_carboxyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011763">
        <property type="entry name" value="COA_CT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011762">
        <property type="entry name" value="COA_CT_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045190">
        <property type="entry name" value="MCCB/AccD1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22855">
        <property type="entry name" value="PTHR22855"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01039">
        <property type="entry name" value="Carboxyl_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50989">
        <property type="entry name" value="COA_CT_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50980">
        <property type="entry name" value="COA_CT_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CoA carboxyltransferase N-terminal" evidence="1">
        <location>
            <begin position="18"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="domain" description="CoA carboxyltransferase C-terminal" evidence="2">
        <location>
            <begin position="274"/>
            <end position="524"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN11127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="534" mass="56315" checksum="9098282ADCE0CAC8" modified="2018-04-25" version="1">MAVLRSHISPSSEVFRRNSAAYGALREQIAAARAAATAGGGAAAQARHAARGKLTARERVTRLLDPGTPFLEIGQLAAHEVYEQAVPSAGIITGVGMVEGRPTVVFANDATVKGGTYYPLTVRKHLRAQQVARENGLACIYLVDSGGVFLPMQEDIFPDENHFGKIFRNIAEMSAMGLPQIAAVMGSCTAGGAYIPAMCDETVIVRGNGSIFLGGPQLVRAATGVIVDAETLGGADLHTATSGVADHLALDDEHALTLVREIAARSGTGTPAAPPEIPAEPLYDPAELPGIVSANPREPIPAREILARLLDGSEFTEYRARFGTTIVCGTGRIGGYPVGVLINDGVLFSESAQKAANFIELCSQRGIPLLFLHNINGFMVGAEYEAGGIAKHGAKMVNAASCAAVPKFSMLIGGSYGAGNLAMCGRSIGPQLMAMWPNAKTSVVGGEQAATVLALIKNEQLAKEGRSLTPEEEEAFKKPIRDNYDREGQPLYVAARLWVDAVVDPADTREWLTLSLALAAAAPQRETRFGVFRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JWV3</accession>
    <name>A0A2M9JWV3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">4-hydroxybenzoyl-CoA thioesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CG723_09750</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN11217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN11217">
        <property type="protein sequence ID" value="PJN11217"/>
        <property type="gene ID" value="CG723_09750"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="SSF54637"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PJN11217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="158" mass="17361" checksum="A01B627CDBD72407" modified="2018-04-25" version="1">MTPLPLLHSTVRTEWIDYNGHMSEAFYVLVFGHATDALMIETGLHSGYRESTGCSLYTVESHLRYLRDVPEGATLAVRSRVLGAAAKKARFTHEMYIVAAPGAEPAEDAQPVATTELLAVHVDQKAGRAAPFPDEVRERFTELTEPPPEWAGRSIAVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JX85</accession>
    <name>A0A2M9JX85_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CG723_10605</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CB01635</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN11367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN11367">
        <property type="protein sequence ID" value="PJN11367"/>
        <property type="gene ID" value="CG723_10605"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="47"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="78"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="107"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="174"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="205"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="43"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PJN11367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="238" mass="25004" checksum="08B6146A5C6B8D1F" modified="2018-04-25" version="1">MPPWSGPLTPSPGSAPPDDCLANNDWICREYLSTRRHILLDAVVQHLQLTALAVLIALVIAVPLAVLARRWSLAAGPVLGLTTILYTIPSLAMFSLLLPAYGLSASLVVAGLVLYSLTLLVRNILAGLRAVPEDTRQAARGMGYGPVRLLLTVELPLALPAAMAGLRIAMVSAVSLVTVGAIVGYGGLGNLIYAGMNTFFKAQVLTASVLCVVIAVVADLLLLGVQRILTPWTRASHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JXH8</accession>
    <name>A0A2M9JXH8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DNA-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CG723_11160</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CB01635</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CdaR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN11457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN11457">
        <property type="protein sequence ID" value="PJN11457"/>
        <property type="gene ID" value="CG723_11160"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2840">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041522">
        <property type="entry name" value="CdaR_GGDEF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025736">
        <property type="entry name" value="PucR_C-HTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042070">
        <property type="entry name" value="PucR_C-HTH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17853">
        <property type="entry name" value="GGDEF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13556">
        <property type="entry name" value="HTH_30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GGDEF_2" evidence="4">
        <location>
            <begin position="311"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="domain" description="HTH_30" evidence="3">
        <location>
            <begin position="485"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF17853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PJN11457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="548" mass="56091" checksum="F63EC7AAFDB67C7F" modified="2018-04-25" version="1">MQLPPPGPPPSPDAAAAHGGGAPTLGQAVGVVGPDVVEVLRAPCGTDVPVSGAGVFDEGETLQARGRILIAPGVDTSAPGAAGVLRAADRAGAAAVVLRRGAQGISPSLAEAADEVSTALLSRAPWIEWGELIGLLRAAIARTGTAAPAEASPDVALGDLSGLALALAALVGGAITVEDPESNVLAYSPTADTADPLRRLTILGRRVPSWRVTELAESGFLTTLWASGDVVHRPADARFPERLAVAVRAGDEILGSLWAAADGEPLPPGARDALRQAAAIAVPHLLHHRLRSRSAASRRRYAVRALFEERPPDVSAAAVVLGVEAGQPCTVLTAAVAVPIAPDVLDRAFHLASLRVAAHHTPAFAHRDGDRLDVLLAGTGAGDGVDQLARDLAGVLRGAGARPLVATGPAVGGLGDAAASRAGAAQVLRVLRERGGPETACAEDVRFAMDALRVTDAVAEHVPSAADAVAALLEHDERHGTDLPRTVAAHLVFFGDAAATARYVGVHTNTLRYRLRRAGELCGIDLTDPDVRLLVELGLRRAGLIPLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JY70</accession>
    <name>A0A2M9JY70_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_13365</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN11826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN11826">
        <property type="protein sequence ID" value="PJN11826"/>
        <property type="gene ID" value="CG723_13365"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025326">
        <property type="entry name" value="DUF4232"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14016">
        <property type="entry name" value="DUF4232"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014721799" evidence="2">
        <location>
            <begin position="31"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="23"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN11826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="213" mass="20489" checksum="8BC0CC35AB946C7D" modified="2018-04-25" version="1">MRVQKLSLLAVAVVAGLSLTACQSGDDSSAGSDDSSSSAQSSGSQSSGSQDSGGSSASTGNGTSTAGSEASTGGSSNGGSGTGTGACQTSHLAFSSSGGMAEGTLIVNLKNTGSATCTLKGFPGADLKGKDGTVSAERSKLAAPSVSVKPGEETRFTLHYPSNDSGGSGVTFTSLVVTPPNETHSHTLPVTINVPATDGSGPAITVDPVGTGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JY74</accession>
    <name>A0A2M9JY74_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Carboxymuconolactone decarboxylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_13350</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN11823.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN11823">
        <property type="protein sequence ID" value="PJN11823"/>
        <property type="gene ID" value="CG723_13350"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051920">
        <property type="term" value="F:peroxiredoxin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029032">
        <property type="entry name" value="AhpD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004675">
        <property type="entry name" value="AhpD_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003779">
        <property type="entry name" value="CMD-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02627">
        <property type="entry name" value="CMD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69118">
        <property type="entry name" value="SSF69118"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00778">
        <property type="entry name" value="ahpD_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CMD" evidence="2">
        <location>
            <begin position="36"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02627"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN11823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="176" mass="18869" checksum="9E44266D9517DD1C" modified="2018-04-25" version="1">MYTSEQGPASGPEKSTSNQSAAGSTPRRIFIDKQSPKAYHALVQTSETVRAAAADAGLDRRLVELVNLRVSQINGCAYCLRVHTRAAQRAGETTERLGVLSAWRDTELFSPTERAALGLAEATTVPSDAVAQESAYTTARAELTEDQIAAVIWVAVTINAFNRVSILSKHPVRADG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JYT3</accession>
    <name>A0A2M9JYT3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">LysR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_14605</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LysR transcriptional regulatory family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN12034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN12034">
        <property type="protein sequence ID" value="PJN12034"/>
        <property type="gene ID" value="CG723_14605"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005119">
        <property type="entry name" value="LysR_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000847">
        <property type="entry name" value="Tscrpt_reg_HTH_LysR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00126">
        <property type="entry name" value="HTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03466">
        <property type="entry name" value="LysR_substrate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00039">
        <property type="entry name" value="HTHLYSR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50931">
        <property type="entry name" value="HTH_LYSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH lysR-type" evidence="2">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN12034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="298" mass="32028" checksum="40087C04CAB49508" modified="2018-04-25" version="1">MSLRQFEYALAIAEEGSVTAAAERLHVAQPSVSQQIRGLERELGVELFARTPTGLVPTVVGRAFLREAEAAVSAARRARATARAGADELVGELVVAVQMGFGTRQLPGALGSLRRRFPRLEVTVFEEPSSAELERLGRRGVLDLALMAACEQSPADAHHLGDEEFVVALAAGHRQLAAERVELRELEREPWVRFDRDSALDGVLLNVLRDNDLAPTTAARVSQTATAVRWAAHGLGVTLVPASAVPHGYEHLVRPVFPVVSQPVIAVVRPGAGPAETALLELLRHETWSESASFSPAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JZ02</accession>
    <name>A0A2M9JZ02_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Hydrogenase expression protein HypE</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CG723_14345</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CB01635</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="3">Heterodimer of a large and a small subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the [NiFe]/[NiFeSe] hydrogenase small subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN11987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN11987">
        <property type="protein sequence ID" value="PJN11987"/>
        <property type="gene ID" value="CG723_14345"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009375">
        <property type="term" value="C:ferredoxin hydrogenase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051538">
        <property type="term" value="F:3 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008901">
        <property type="term" value="F:ferredoxin hydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.700">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.480.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027394">
        <property type="entry name" value="Cytochrome-c3_hydrogenase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006137">
        <property type="entry name" value="NADH_UbQ_OxRdtase-like_20kDa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037148">
        <property type="entry name" value="NiFe-Hase_small_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037024">
        <property type="entry name" value="NiFe_Hase_small_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001821">
        <property type="entry name" value="NiFe_hydrogenase_ssu"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30013">
        <property type="entry name" value="PTHR30013"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14720">
        <property type="entry name" value="NiFe_hyd_SSU_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01058">
        <property type="entry name" value="Oxidored_q6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000310">
        <property type="entry name" value="NiFe_hyd_ssu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0003">3Fe-4S</keyword>
    <keyword evidence="8" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="7 8" id="KW-0408">Iron</keyword>
    <keyword evidence="8" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="4 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Oxidored_q6" evidence="9">
        <location>
            <begin position="36"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="domain" description="NiFe_hyd_SSU_C" evidence="10">
        <location>
            <begin position="232"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="36"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="154"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="195"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="237"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="240"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="260"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="266"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="294"/>
        </location>
        <ligand>
            <name>[3Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:21137"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="297"/>
        </location>
        <ligand>
            <name>[3Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:21137"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000310-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF14720"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PJN11987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="362" mass="38666" checksum="BFA8784F67D46F51" modified="2018-04-25" version="1">MDAATPTVVDSDVPGLPAEEESPTIHILWINAGLSCDGDSVALTAAMQPSIEEIVLGVLPGLPKIAVHWPLIDFECGPVGGADTFIEWFFKGERGEIDPFVLVVEGSIPNEAIKPEGYWCGFGDDPETGQPITTSEWIDRLAPKALAVVAIGTCATYGGIHAMAGNPTGAMGVPDYLGWDWKSQAGIPIVCVPGCPIQPDNFSETLTYLLYQAAGSAPMIPLDDKLRPTWLFGATVHEGCDRAGYYEQGQFATTYDSPKCLVKLGCWGPVVKCNVPKRGWMNGIGGCPNVGGICIACTMPGFPDKFMPFMDEPPGGKLSSAASGAYGSVIRKLRSITAKTVDKEPKWRNRGKALTTGYRPPW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JZ05</accession>
    <name>A0A2M9JZ05_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alkanesulfonate monooxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_09370</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN12112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN12112">
        <property type="protein sequence ID" value="PJN12112"/>
        <property type="gene ID" value="CG723_09370"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011251">
        <property type="entry name" value="Luciferase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036661">
        <property type="entry name" value="Luciferase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00296">
        <property type="entry name" value="Bac_luciferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51679">
        <property type="entry name" value="SSF51679"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bac_luciferase" evidence="1">
        <location>
            <begin position="8"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN12112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="356" mass="38868" checksum="64B3E2982BB9923C" modified="2018-04-25" version="1">MTPQFLWYIPNTVQPGHRGDDTTSGWGSIEYSTELAHTAEAHGWDGALLGTGWGRPDTFTVATALAARTTTFKPLIAVRPGYWQPANFASAAATLDQLSRGRVLVNIVSGLDTPAAYGDTTVDPAARYARTQEFLHLVRRLWTEENVTFHGEHFQVTGSTVSPRPYATAERAHPTLYFGGASEAAERVSAAEADVQLFWGEPLDGIAERIARLKELSGRVGRRHVPLEYGLRITTVVRDTTEEAWRAAEEKVAKMAADAGEIDTWTGNRRTAVGQRRLLDLTERGEVLDTCLYTAPGRFGGGGAATTWLVGSPDDVAAALNAYRALGITHFVLSDTPYKEETSRIGDQLLLRLREA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JZ15</accession>
    <name>A0A2M9JZ15_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CG723_09735</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN12122.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN12122">
        <property type="protein sequence ID" value="PJN12122"/>
        <property type="gene ID" value="CG723_09735"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PJN12122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="628" mass="70438" checksum="AEAFD96E0F4EEF2F" modified="2018-04-25" version="1">MTMLLGPRGSGTSELLCVLMEQFGTQYPFGYVKFTSGQELLPRYALGLLARQLARNLPSYRHTSFPRLALGLLASDQDLPHQALTGGQRGIRGALTDLEKKAKHQHGDYLGAYLTVAQASIDAPEGASRSARTLLSAATDTSARSWAGRWDHSAAAWFGQHRLTHSSDPWESLLELNRWRHQGDERDKLRLDQLLCAAFLEDLRTSVKGPFRPRSYLLLLDETHTDHGREFLDLLLQARHDDTVLGRRPCDPLSVVAGCNRWLPRWGPATGEEWPWRPREPDRASLADWREHRPSGDGQDTWWYPLRMRDLDREEVRIHVEQQLNTHPELGPFTTLAPFVHRLTGGLPKAVQQVFEVLGGPNVPQVPGPQQNLWLRDLPQRTVSAGGRKPLLVDAALDDLLADFDAADRDRLAQCAAADDLFVGAQLLGRGAELFTDIRSRWLLSAPGTLSLHPWLRRMLLWHLAGRAGAWDTAHEVLAEHYANGEHRVQELYHLLALEKVDEVAEYLVTLRNTARTEEWLSAFHAITSAPNRLAHPGGPLELRARLAPSDPGDQVTVPAVIRDLVVARWLWSDPLTDPGRQLSPVLADGFVHLSRLWRNYNVALVNEAERYRLTTPTRTSPILGSGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JZ39</accession>
    <name>A0A2M9JZ39_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Diaminopimelate decarboxylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CG723_11155</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CB01635</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the Orn/Lys/Arg decarboxylase class-II family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN12153.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN12153">
        <property type="protein sequence ID" value="PJN12153"/>
        <property type="gene ID" value="CG723_11155"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008836">
        <property type="term" value="F:diaminopimelate decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009089">
        <property type="term" value="P:lysine biosynthetic process via diaminopimelate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.37.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009006">
        <property type="entry name" value="Ala_racemase/Decarboxylase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002986">
        <property type="entry name" value="DAP_deCOOHase_LysA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022643">
        <property type="entry name" value="De-COase2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022657">
        <property type="entry name" value="De-COase2_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022644">
        <property type="entry name" value="De-COase2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000183">
        <property type="entry name" value="Orn/DAP/Arg_de-COase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029066">
        <property type="entry name" value="PLP-binding_barrel"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02784">
        <property type="entry name" value="Orn_Arg_deC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00278">
        <property type="entry name" value="Orn_DAP_Arg_deC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01181">
        <property type="entry name" value="DAPDCRBXLASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01179">
        <property type="entry name" value="ODADCRBXLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50621">
        <property type="entry name" value="SSF50621"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51419">
        <property type="entry name" value="SSF51419"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00879">
        <property type="entry name" value="ODR_DC_2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="2" id="KW-0457">Lysine biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Orn_Arg_deC_N" evidence="5">
        <location>
            <begin position="37"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="domain" description="Orn_DAP_Arg_deC" evidence="4">
        <location>
            <begin position="290"/>
            <end position="384"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02784"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PJN12153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="448" mass="46962" checksum="2982AE7DF203FC08" modified="2018-04-25" version="1">MAPESVVRREAAVRAAASQGLVGAQASVLGLLDVDGIRGAARELREAFAFDGVSVQHTFAVKAASLVPVLALLNEEGIGAEVASAGELALARAAGVPAERIVFDSPAKTMDELRDALAHGIAVNADNPQELDRVDAVVADLGVGCAPVGLRVNPQVGSGSIGAMSTATATSKFGVALRDEGAEQWVLDAYRLRPWMSRLHTHTGSQGVALELMAEGVRAAYELAEKINAQVGRQQIDTLDIGGGLPVNFASDEVTPTFAQYARLLRETVPGLFDGRYTLVTEFGRSLLAKQGLIVAHVEYTKTSGGRRIAVTHAGAQVATRTVFVPESWPLRVGAYDPAGRPRATEPLVQDVAGPCCFAGDLVARERELPELAPGDLVALYDTGAYYFSTHFHYNSLPRPAVYGYVVSDAGVVKFAPVRPAQTVAEVVAESGAAQAGSLLGLTGRPSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JZC0</accession>
    <name>A0A2M9JZC0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_13605</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN12214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN12214">
        <property type="protein sequence ID" value="PJN12214"/>
        <property type="gene ID" value="CG723_13605"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010343">
        <property type="entry name" value="ArAE_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06081">
        <property type="entry name" value="ArAE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="29"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="57"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="87"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="180"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN12214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="418" mass="46604" checksum="F18EDBF4EC22BDCB" modified="2018-04-25" version="1">MRLVPERLAKLLSRVPNGRQLVKRLRHPVAVQTLRATAAATIAYVIALHLSREPAPLTAPLTALLVVQVTLYATVKMSIRRINSVVVGVFIAIGFSALVGLTWWSLALIILASLTIGPFVRANEFVPEVAISAMLVLGVTRVASSAWDRVLETLIGALTGLAFNLFFAPPLWVDTAGDALEDLARRMRRLLLDLSDQLDEETPWPLAAARLHEARRLDQDIADVDASLRQAEDSLRLNPRVREGRLHRVVLRTGLDTLEICTVVLRVIARTLTDLAKQRDDRWLLEPEVSNAMRDLFGHVADAVVSFAVLVGTGTSSESETAEDRLISHLAAANVQREHVARLLLDAVQDDPSQWQLQGALLTEIDRILAELDTEHRSQRLMEELDRNAQQLHERFPSLVGVQQWARRHRPRVRRKGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-05-25" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JZM3</accession>
    <name>A0A2M9JZM3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Aldo/keto reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_04545</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000002">
        <property type="protein sequence ID" value="PJN12329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN12329">
        <property type="protein sequence ID" value="PJN12329"/>
        <property type="gene ID" value="CG723_04545"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NADP_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="SSF51430"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldo_ket_red" evidence="1">
        <location>
            <begin position="26"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN12329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="342" mass="36532" checksum="28AC74D2BD094BA5" modified="2018-04-25" version="1">MSSTEQPQRISTVELGNNGPMVGVQGLGCMGMSWAYGPTDADEARATLERGLELGVTLYDTADAYAAGENEKFLAPFLKAHRDEVVLATKFALGVDPSDPTKRVINNDPEYIRACIDASLQRLGVDTIDVYYMHRRDVNVPIEETVGVMAELVAAGKVKHLGLSEVTGGELRAAQAVHPIAALQSEWSLFSRDIEKEVVPTAAELGVALVPYSPLGRGFLTGSFVSADKELGADDFRRQQPRFTGDNAAANAALLEPVRQVAEAHGASLGQIALAWVQQQSGAFGLPVVPIPGTRKRSRIEENAAATRITLTDAELALIAPIASQVAGDRYADMTFTSAGRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K072</accession>
    <name>A0A2M9K072_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF1996 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CG723_05580</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000002">
        <property type="protein sequence ID" value="PJN12504.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN12504">
        <property type="protein sequence ID" value="PJN12504"/>
        <property type="gene ID" value="CG723_05580"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018535">
        <property type="entry name" value="DUF1996"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09362">
        <property type="entry name" value="DUF1996"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014832027" description="DUF1996 domain-containing protein" evidence="2">
        <location>
            <begin position="40"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="domain" description="DUF1996" evidence="3">
        <location>
            <begin position="261"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="155"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="183"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF09362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PJN12504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="506" mass="53147" checksum="4901B68CD85BBC6D" modified="2018-04-25" version="1">MGRTSRKRRSSLATRMTVASAALLLGGGGLVAVNVYASAHEENPAQRGDGAQQQQQQVATIDCPDVGNGLSDVPDAARSEVDGELATMDSQITESYQRLAASRDAAARDPEFVQNSILQPLKERRSTLIDRIGLEISRAGGTAPEGMKDLAACTARSAGTDGSPPAGSAAPSAPADGGQADGGQQDGGQQGDGGQQGGGQDGGQGGGQQNGNGPDASDFVDINSVQPNVKTPPSQRAASRGTFTTKCGRNENGKFNPDNVIVAPGVSNGAHHMHDYVGNQANDAFASDDDLANGDTSCRNQGDKSTYYWPVLRLQNGKDENDAQADGGGKDQNVGEIQTPASVTLKFVGNPTGKVVAMPRFLRIITGDAKAFTNGDANANASWSCTGFEDRQLKDKYPICPEGSKVVRSFKFQSCWDGRNTDSANHRTHVAFADPASGACPQGFQAIPQLQQRIVYDVPPGPGFAVDSFPEQLHKPVTDHGDFINVFDEGLMKRVANCINRGQRCT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K0B9</accession>
    <name>A0A2M9K0B9_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Cytochrome bc1 complex Rieske iron-sulfur subunit</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Cytochrome bc1 reductase complex subunit QcrA</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Rieske iron-sulfur protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">CG723_05915</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">CB01635</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Iron-sulfur subunit of the cytochrome bc1 complex, an essential component of the respiratory electron transport chain required for ATP synthesis. The bc1 complex catalyzes the oxidation of menaquinol and the reduction of cytochrome c in the respiratory chain. The bc1 complex operates through a Q-cycle mechanism that couples electron transfer to generation of the proton gradient that drives ATP synthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the Rieske iron-sulfur protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000002">
        <property type="protein sequence ID" value="PJN12568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN12568">
        <property type="protein sequence ID" value="PJN12568"/>
        <property type="gene ID" value="CG723_05915"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.102.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045603">
        <property type="entry name" value="QcrA_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017941">
        <property type="entry name" value="Rieske_2Fe-2S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036922">
        <property type="entry name" value="Rieske_2Fe-2S_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014349">
        <property type="entry name" value="Rieske_Fe-S_prot"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10134">
        <property type="entry name" value="PTHR10134"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19297">
        <property type="entry name" value="QcrA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00355">
        <property type="entry name" value="Rieske"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50022">
        <property type="entry name" value="SSF50022"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51296">
        <property type="entry name" value="RIESKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-0408">Iron</keyword>
    <keyword evidence="10" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="15" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="15" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="56"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="84"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="162"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="domain" description="Rieske" evidence="16">
        <location>
            <begin position="244"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00015816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00029586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00032409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="PJN12568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="351" mass="38457" checksum="CBE302AA8CFC2DB0" modified="2018-04-25" version="1">MSQEIPEENLPSAQDADQPHGSVAVKEDPFANPGLPPHEHRIQDIDERAARRSERVVAFLFTLSMLSTVAFIAAFVTIKADKSVFIWPIGHISALNFALGMTLGLALFCIGAGAVHWARTLMSDVEVADDRHAISAEPEVKAKVLADFKQGAKESQFGRRKLIRNTLFGAVAMVPLSGIVLLRDLGPLPEDKLRHTAWKKGKLLVNMNTNEPLRPSDIVVGSLTFAKPEGVEEHDEDFQQVMGKAALMLVRIQPDEIKDKQELAWGHEGVVAYSKVCTHVGCPISLYEQQTHHVLCPCHQSTFDLSDGARVIFGPAGHALPQLRIGVNDEGYLQALGDFAEPVGPAFWERG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K0T4</accession>
    <name>A0A2M9K0T4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CG723_06945</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CB01635</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000002">
        <property type="protein sequence ID" value="PJN12742.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN12742">
        <property type="protein sequence ID" value="PJN12742"/>
        <property type="gene ID" value="CG723_06945"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032808">
        <property type="entry name" value="DoxX"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13564">
        <property type="entry name" value="DoxX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="31"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="66"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="95"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="120"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PJN12742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="152" mass="15607" checksum="078470DDABEECE3F" modified="2018-04-25" version="1">MSETTAPVTTAASAASVPAAPAAGRARAARIALRTLTVLLALFYGVASALPKLIAHPSAVESFDTIGWGSAAMYIIGVLELAGGIALLVPVLSGVAPIALSALMAGAFVVQMSYFDGENAATPLILIVPLALLAWTRRRSNADLVRLVKRRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-09-29" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K0Z3</accession>
    <name>A0A2M9K0Z3_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 7">6-phosphogluconolactonase</fullName>
            <shortName evidence="7">6PGL</shortName>
            <ecNumber evidence="5 7">3.1.1.31</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7 9" type="primary">pgl</name>
        <name evidence="9" type="ORF">CG723_07260</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CB01635</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 7">Hydrolysis of 6-phosphogluconolactone to 6-phosphogluconate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>6-phospho-D-glucono-1,5-lactone + H2O = 6-phospho-D-gluconate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:12556"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57955"/>
            <dbReference type="ChEBI" id="CHEBI:58759"/>
            <dbReference type="EC" id="3.1.1.31"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 7">Carbohydrate degradation; pentose phosphate pathway; D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage): step 2/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 7">Belongs to the glucosamine/galactosamine-6-phosphate isomerase family. 6-phosphogluconolactonase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.31" evidence="5 7"/>
    <dbReference type="EMBL" id="NNBL01000002">
        <property type="protein sequence ID" value="PJN12802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN12802">
        <property type="protein sequence ID" value="PJN12802"/>
        <property type="gene ID" value="CG723_07260"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00115">
        <property type="reaction ID" value="UER00409"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017057">
        <property type="term" value="F:6-phosphogluconolactonase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006098">
        <property type="term" value="P:pentose-phosphate shunt"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01400">
        <property type="entry name" value="6PGL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005900">
        <property type="entry name" value="6-phosphogluconolactonase_DevB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006148">
        <property type="entry name" value="Glc/Gal-6P_isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039104">
        <property type="entry name" value="PGLS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11054">
        <property type="entry name" value="PTHR11054"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01182">
        <property type="entry name" value="Glucosamine_iso"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="SSF100950"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01198">
        <property type="entry name" value="pgl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glucosamine_iso" evidence="8">
        <location>
            <begin position="12"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00020337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU365095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PJN12802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="259" mass="27239" checksum="C1F039F43388BA1A" modified="2018-04-25" version="1">MTTAPQLVVHRDKELMAQAAAARLITKIVDAQAARGYASVVLTGGRNGNGLLAALATAPARDAVDWTRLDLWWGDERFLPDGDPERNYTQAREALLDSVPLNPDRVHPMPASDGPYEVDAAAQVYAAELAAAAGPEDHGPVPTFDVLMLGVGPDTHVASLFPELPAVRETERTVVGVHGAPKPPPIRISLTLPAIRAAREVWLLAAGEDKAEAAAIALSGAGEIQAPAAGAYGRSRTLWLLDSAAASQLPPELYPPHVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K151</accession>
    <name>A0A2M9K151_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_07025</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000002">
        <property type="protein sequence ID" value="PJN12757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN12757">
        <property type="protein sequence ID" value="PJN12757"/>
        <property type="gene ID" value="CG723_07025"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043917">
        <property type="entry name" value="DUF5753"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19054">
        <property type="entry name" value="DUF5753"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="19"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN12757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="289" mass="32547" checksum="A9EB94542D722C8B" modified="2018-04-25" version="1">MSEPRSAPTVGQVVLGRRLQDLRERAGLKREEAAKVLRVAPATVRRMEMAEVGLKIPYLQLLLKSYGVTDEEADAFVTLAEEANKPGWWQRFHDILPGWFSMYVSLEGAASLIRSYEPHFVPGLLQTEDYARGVLRSGAVGRALAEDPDVVERHVALRMQRQELITREEAPRLWMVMDETALRRPVGGPDVMRGQIDRLLEVTELANVTLQIAEFAAGPHPGTYGPFVLFRFAMSELPDMVYSEYLTGAVYLDARPEVATHLEVMDRMAAHAATAHRTKDILRDLRKEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K1B4</accession>
    <name>A0A2M9K1B4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Rieske (2Fe-2S) protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CG723_07335</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000002">
        <property type="protein sequence ID" value="PJN12817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN12817">
        <property type="protein sequence ID" value="PJN12817"/>
        <property type="gene ID" value="CG723_07335"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.102.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017941">
        <property type="entry name" value="Rieske_2Fe-2S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036922">
        <property type="entry name" value="Rieske_2Fe-2S_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00355">
        <property type="entry name" value="Rieske"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50022">
        <property type="entry name" value="SSF50022"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51296">
        <property type="entry name" value="RIESKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rieske" evidence="4">
        <location>
            <begin position="9"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PJN12817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="110" mass="11985" checksum="0FE43D73B366ECAA" modified="2018-04-25" version="1">MAFDRARFTRACGLSELEEDTPKRVELDGTPVSVVYTEGEVFAINDICSHANVSLSEGEVEDCQIECWLHGSAFDLRTGKPSGLPATRPVPVYPVQIEGDDVLVSLSQES</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-06-02" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K1G8</accession>
    <name>A0A2M9K1G8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">FadR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CG723_04675</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000002">
        <property type="protein sequence ID" value="PJN12966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN12966">
        <property type="protein sequence ID" value="PJN12966"/>
        <property type="gene ID" value="CG723_04675"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07377">
        <property type="entry name" value="WHTH_GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.530">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011711">
        <property type="entry name" value="GntR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008920">
        <property type="entry name" value="TF_FadR/GntR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07729">
        <property type="entry name" value="FCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
        <property type="entry name" value="GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00895">
        <property type="entry name" value="FCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00345">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48008">
        <property type="entry name" value="SSF48008"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50949">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH gntR-type" evidence="5">
        <location>
            <begin position="31"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="12"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PJN12966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="262" mass="28199" checksum="9E34E3006C59BF11" modified="2018-04-25" version="1">MRKDRGSSRTESPRTDSASQDGTPGVSYTGRGVHRTVVEALARQIFDGTYAEGDLLDLPGLMAELDVSQTVLREAIKVLTTKGLLDARQKRGTFIRPRDDWNLLDSDVLRWTIDSGAPGAFFTDLLELRRAVEPAAAALAALHRTDADLAALDAALSAMAAAEQAPVTADPVMTDSDPVLAVRADASFHTALLTASGNPFFAQMRRVIIPALVVRDRLVHAGRHEHPLPAHALVADRVRARDQDGAFAAMLDVIDLSRSGHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-09-29" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K273</accession>
    <name>A0A2M9K273_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">PGA biosynthesis protein CapA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CG723_01145</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CB01635</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CapA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000001">
        <property type="protein sequence ID" value="PJN13226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN13226">
        <property type="protein sequence ID" value="PJN13226"/>
        <property type="gene ID" value="CG723_01145"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd07381">
        <property type="entry name" value="MPP_CapA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019079">
        <property type="entry name" value="Capsule_synth_CapA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09587">
        <property type="entry name" value="PGA_cap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00854">
        <property type="entry name" value="PGA_cap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="SSF56300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014980733" evidence="2">
        <location>
            <begin position="27"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="domain" description="PGA_cap" evidence="3">
        <location>
            <begin position="43"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00854"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PJN13226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="405" mass="43410" checksum="129A8FE149A48AFF" modified="2018-04-25" version="1">MNRRPSRRSWSGIALSALLAGTAACGPFGSDDGKAAADGPSFTVAAAGDILIHPQLTEQARKDAKVTGRGEKGLDFDPMLAGVKPVISKADLAICHFEPVAGKPEGPFESYPAFLVPPQIATTIKHVGYDTCSSASNHTLDHGVAGVQNTLNVLDRAGLKHTGSARSAAEAAKPLIMEVKGVKVAQLSYAFGFNGNEIPADKPWLVNQIDFRNIAAAEKRARAAGADVVILSIHWGRENQPNPSRSQLQLGRKLARETGIDLIIGHHAHVVQPMEKVDGTWIAYGLGNQIARHDVPTGLTEEGVIGWFEFTKRAGKWDVQAKYVPTFTQIPPDPDESGNLPKGAVENHRLVDIAAALRDGRGDGDTKLSEQQRARYRLAFERTEGTMLNRGAAKDGLAPLEPLPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K2G1</accession>
    <name>A0A2M9K2G1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_01720</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000001">
        <property type="protein sequence ID" value="PJN13324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN13324">
        <property type="protein sequence ID" value="PJN13324"/>
        <property type="gene ID" value="CG723_01720"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010390">
        <property type="entry name" value="DUF990"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06182">
        <property type="entry name" value="ABC2_membrane_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="57"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="96"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="151"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="175"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="217"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="265"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN13324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="299" mass="32071" checksum="A509B73963902CE1" modified="2018-04-25" version="1">MPLSRAPEPARPVHPGPAHPVHPAPGHPVHPVRPTVRAPYRSLYLASLQQALAHRRAVLVDLAGNAVWAAVLYYLWRSIFAGATSVGGYSWDQMRTYVLLSFALGQLLAFQAEMQMHRDIRSGQVALDLVRPVNYPAMQLVRALGAGTPHMAGALAGTAVIGGVLLHALPPHSPAAALLFLLTLAVGVTVNAMLCFLASLLCFWTESAYGLILARQAVTTFMAGGMVPLALFPAPLRVVAEWLPFSAIVSTPVQMYLGRLTGDDALLALGRQLAWTVVMSALTVRLWRAARHHLTVNGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K2I7</accession>
    <name>A0A2M9K2I7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CG723_01780</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CB01635</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000001">
        <property type="protein sequence ID" value="PJN13335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN13335">
        <property type="protein sequence ID" value="PJN13335"/>
        <property type="gene ID" value="CG723_01780"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017039">
        <property type="entry name" value="Virul_fac_BrkB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30213">
        <property type="entry name" value="PTHR30213"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03631">
        <property type="entry name" value="Virul_fac_BrkB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="55"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="164"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="205"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="236"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="277"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="327"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="328"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="362"/>
            <end position="391"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PJN13335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="391" mass="42841" checksum="9B3C2883279D0FFD" modified="2018-04-25" version="1">MHQAKETPDRPHRGRLHRARALYRNVSKRRTAWLLLKDTVNSCMEYRILGLAAEAAFFTLLSVPPLLLSLIGLLAYVDTWTGADTIAGVRDNILEASRTVLSDQGVKEIARPILDDAMTGRPDVISIGFLFSLWSGSRAVSTFVDTVTVMYGLDGVRGIVKTRLLAFLLFLGALIVGSVALPLMIAGPDAVIALVPWSETVVQVLYWPVVLLLSVVFLTTLYHVSVPVRSPWIEDVPGALVALAMWVPGSFLLRLYITSTIEGPTIYGGLAAPVAVLLWIGVSAFAVLVGAAVNAAIDRVWPSVATSVARAANERWRTAQAAEYIARSAAREGHRGTDDADDPDMPSEFPERWSKFLPPDDVSSRLRTHVRKNGDHPQDPNPRDHDHHDHN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K2Q4</accession>
    <name>A0A2M9K2Q4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Sulfate ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CG723_01635</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CB01635</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000001">
        <property type="protein sequence ID" value="PJN13307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN13307">
        <property type="protein sequence ID" value="PJN13307"/>
        <property type="gene ID" value="CG723_01635"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="53"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="112"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="143"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="169"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="211"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="268"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="105"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PJN13307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="307" mass="32655" checksum="D268B79A9B256366" modified="2018-04-25" version="1">MASTETTTAGKDTGAVKDTLPGQDLAGLEAGLDALDTVHTARTPLRQTLVQKVLPPLTAVLLVLVVWQGLVSFKIVDDPSKLPSPSAVWDEVSDAWLQGTLLDYIWTSVSRGLLGFLLALVIGTPLGLVVARVRFIRSAIGPILSGLQSLPSVAWVPPAVIWLGLDNKMMYAVILLGAVPSIANGLVSGVDQVPPLFLRAGRTLGATGLRHTWHIVLPAALPGYLAGLKQGWAFSWRSLMAAEIIASSPDLGIGLGQLLENGRNASSMSMVFLAIFLILIVGIVIDLLIFSPLERRVLRSRGLLVRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K2U9</accession>
    <name>A0A2M9K2U9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">AMP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CG723_02095</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000001">
        <property type="protein sequence ID" value="PJN13390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN13390">
        <property type="protein sequence ID" value="PJN13390"/>
        <property type="gene ID" value="CG723_02095"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-binding" evidence="2">
        <location>
            <begin position="35"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding_C" evidence="3">
        <location>
            <begin position="457"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PJN13390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="548" mass="60165" checksum="01ABBE1F0F34A7D2" modified="2018-04-25" version="1">MTSEPRTTARPPALSYAHGTDPAPLLGDTIGRNLDRAVAAYPDRDALVDVPSGRRWTYAQFGADVDQLARGLLAAGVLKGDRVGIWAVNCPEWVLVQYATARIGAVMVNINPAYRAHELEFVLKQAGVCVLVASTEHKGSDYRALVRQVRERCPELRETVFIGDPGWDALTAGADAVTAEQLDARQAELSCDDPVNIQYTSGTTGFPKGATLSHHNILNNGFWVGETVGYTEQDRVCLPVPFYHCFGMVMGNLGATSHGACIVIPAPSFDPVATLHAVERERCTSLYGVPTMFIAELNLADFATYDLSSLRTGIMAGSPCPVEVMKRVVAEMHMAEVSICYGMTETSPVSTQTRRDDDLERRTGTVGRVLPHIEVKVVDPVSGVTLPRGEPGELCTRGYSVMLGYWDEPEKTAEVIDPGRWMHTGDLAVLREDGYVQIVGRIKDMIIRGGENVYPREIEEFLYAHPKIADVQVVGVPDERYGEEVLACVILRDPEDTLTLEELRAYCRDRLAHYKTPARLRILDAFPMTVSGKVRKIELREGYGADAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K3A0</accession>
    <name>A0A2M9K3A0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_03350</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000001">
        <property type="protein sequence ID" value="PJN13604.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN13604">
        <property type="protein sequence ID" value="PJN13604"/>
        <property type="gene ID" value="CG723_03350"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011053">
        <property type="entry name" value="Single_hybrid_motif"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51230">
        <property type="entry name" value="SSF51230"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="29"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN13604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="267" mass="27720" checksum="15E78F1CBA119730" modified="2018-04-25" version="1">MQFRQQALSKLQSPEELDLPVRLARPQGVLALAVTLVVMAAASVWAVTGSLSSTLRVPGVLTHAQGSYVLQSPVTGQVTGVLAKEGQRLAANSPLLKVSTPQGDRYVRTVDAGRVTTLVARIGAVVTTGSDVATVEKTGAKDPLLAVLYVPADRAGTVPVGADVDLTVQSAPSQQYGMLRGRVQAVGRGAQSSQRVEAFLGDKELATQFTKGGPAVAVLVKLVASSSTKSGYAWSSKGGPPYALDSMTPASGAVHLAEQRPIDWLLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K3J8</accession>
    <name>A0A2M9K3J8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CG723_03895</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CB01635</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the polysaccharide lyase 8 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000001">
        <property type="protein sequence ID" value="PJN13692.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN13692">
        <property type="protein sequence ID" value="PJN13692"/>
        <property type="gene ID" value="CG723_03895"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.220.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008929">
        <property type="entry name" value="Chondroitin_lyas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014718">
        <property type="entry name" value="GH-type_carb-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038970">
        <property type="entry name" value="Lyase_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011071">
        <property type="entry name" value="Lyase_8-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012970">
        <property type="entry name" value="Lyase_8_alpha_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004103">
        <property type="entry name" value="Lyase_8_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003159">
        <property type="entry name" value="Lyase_8_central_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38481">
        <property type="entry name" value="PTHR38481"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02278">
        <property type="entry name" value="Lyase_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02884">
        <property type="entry name" value="Lyase_8_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08124">
        <property type="entry name" value="Lyase_8_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48230">
        <property type="entry name" value="SSF48230"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49863">
        <property type="entry name" value="SSF49863"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="SSF74650"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014844888" evidence="2">
        <location>
            <begin position="30"/>
            <end position="812"/>
        </location>
    </feature>
    <feature type="domain" description="Lyase_8_N" evidence="5">
        <location>
            <begin position="53"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="domain" description="Lyase_8" evidence="3">
        <location>
            <begin position="420"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="domain" description="Lyase_8_C" evidence="4">
        <location>
            <begin position="704"/>
            <end position="768"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF08124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PJN13692.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="812" mass="85354" checksum="851EDFEADDB2A564" modified="2018-04-25" version="1">MDLTRRQTLTLAGATAAAALPLTAGVASAANAAEAADAPAADTFDELLARAEEQLTGGAFDTADPDFAAAVKALDTQASAWWKDLDRNAGRKALWADLSPASDPGMFGQSYPRLRTLATAWATPGTSLTGSAEVADALVAALGFLGSTGYNPARAESGNWWFWEIGAPRALMDTCVLLRSKLPAADLAGHVATVAKFCPNPDRRTNSPSLSETGANRADKAVIVALRGLLARDAATVALARDGLSDVRDNGRRSLFTYVTSGDGFYEDGSFVQHDSVAYTGTYGSVLLGSTGQLIALLAGSDWAVNDPKVSVLYEAVERSFSPVMFDGLMMDALRGRAISRERARDYNDGAVTLTYILQLAAGAPAPYADRWRGLAKGWISRNTANPYAGLVGVPALARAKAVLDDKAIPAAERLAGHFSFADMDRIVHRRPGWALALSLSSKRIAAYEAGNGENLHGWYTGDGMTYLYDGDDLGQFGDGFWPTVDPYRLPGTTVDTRARADLGTGAGTGTYRPKNAVAGGAVLQDRYGAAAMELIADGNTLQARKAWFCLDNAVVALGAGITASDGRTIETVVENRNLHTDGAQRLLVDGRRQPGEQGWSASLSGADWAHLEGTGGYVFPDHPGRRPGDAVPLRALREERTGTWGALNSGADTGGGTDPVTRRYVTVWFDHGSSPTDSSYAYVLLPGASAVATGIWAHSRPVRIVANDATVQAVEARRLGLLAAHFWGPGSAAGLTSSGPGTVLVRRHGDAIAVAVADPGRTGSTLTVELPFPVRKVTRADDTITLTPGRRPVLTVDVAGSRGHSHTAELA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K3S7</accession>
    <name>A0A2M9K3S7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_02605</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000001">
        <property type="protein sequence ID" value="PJN13775.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN13775">
        <property type="protein sequence ID" value="PJN13775"/>
        <property type="gene ID" value="CG723_02605"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="176"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN13775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="469" mass="49644" checksum="AF818BB265C2FE87" modified="2018-04-25" version="1">MLDAVVVGAGPNGLTAAVELARRGLSVAVFEAMDTVGGGARTEELTLPGFRHDPCSAAHPLGINSPAFRDLPLDRYGLEWLHAELPMAHPFPDGSAAVLSRSVAETAASFGPHDAGTYRRLVAPLLPKWDALVRDFMALPLTSLPRDPLTLARFGLTGLPPSTWLMRRFRDDRARALFSGLVAHAIAPLGGLGTGAVGLVFALAGHARGWPVARGGSQSISDALTAYLKDLGGAVHTNYEIKRLDDLPPARAYIFDTSPTALARIAGLGSYYERFRYGASVFKLDYALDGPVPWTAKEARSAGTVQVGPGSRDIAAALRAASREGRAPDKPFLITVQPSVMDPSRAPAGKHVFWAYGHVPSGWDGDLTDAVERQLERFAPGFRDRILARATAGPPELAARNANYVGGDIACGAVSGLQLLLRPKLSLSPYTTPHPAVFICSSASPPGPGVHGMSGHNAAKAVWRRIRAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JEL0</accession>
    <name>A0A2M9JEL0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CG723_45385</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000053">
        <property type="protein sequence ID" value="PJN05336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN05336">
        <property type="protein sequence ID" value="PJN05336"/>
        <property type="gene ID" value="CG723_45385"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PJN05336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="258" mass="26687" checksum="5A4F733575B30276" modified="2018-04-25" version="1">MTAAAPTAASRIAVITGASSGIGAATARQLAAAGYRVVLTARRKDRIEALAAEINDAGHQAAAYALDITDRAAVDEFATAFKTIGVLVNNAGGALGADPVATGDPAQWRQMYETNVIGTLNVTQALLPALTASGDGTVVVLSSTAGLSTYEGGAGYVAAKHAEHVLTETLRLEIVGTPVRVIEVAPGMVKTEEFALTRFGGDTEKAEKVYAGVAEPLSADDVADTITWAVTRPSHVNIDLLVVRPRAQASNTKVHREL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JF02</accession>
    <name>A0A2M9JF02_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NAD-dependent dehydratase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_45075</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000050">
        <property type="protein sequence ID" value="PJN05383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN05383">
        <property type="protein sequence ID" value="PJN05383"/>
        <property type="gene ID" value="CG723_45075"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Epimerase" evidence="1">
        <location>
            <begin position="5"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN05383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="353" mass="37542" checksum="988421C9F610392C" modified="2018-04-25" version="1">MGKVVLVTGVARQLGGRFVRRIQRDPEVDRVIGVDAVAPAHHLGGAEFLQADIRQPAIARLLAEHSVDTVVHLDVTGTPLASGGRGSVKETNVIGTMQLLGACQKAPAVKRLVVKSSTNVYGSAPRDPAVFTETTPPKSLPSGGFAKDTVEVEGYVRGFARRRPDVAVCVLRFANILGPAADSPLAEYFSLPVLPTVLGYDPRLQFVHEDDVIEVLRIASHEPARGTLNSGTFNVAGDGVLLLSQCSRRLGRPTVPVFLPAVTWVGSALRTLGATDFSPEQIRLLTHGRVVSTVQMRETLGYRPEYTTAETFAEFVRGRGPGLLPPEALAGAVDRLASLPFLGGGHPPTQSAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JFB9</accession>
    <name>A0A2M9JFB9_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 4">Protein GrpE</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">HSP-70 cofactor</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3 8" type="primary">grpE</name>
        <name evidence="8" type="ORF">CG723_43630</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CB01635</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3 4">Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 3 5">Belongs to the GrpE family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000044">
        <property type="protein sequence ID" value="PJN05596.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN05596">
        <property type="protein sequence ID" value="PJN05596"/>
        <property type="gene ID" value="CG723_43630"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000774">
        <property type="term" value="F:adenyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042803">
        <property type="term" value="F:protein homodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00446">
        <property type="entry name" value="GrpE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.22.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.20.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01151">
        <property type="entry name" value="GrpE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000740">
        <property type="entry name" value="GrpE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013805">
        <property type="entry name" value="GrpE_coiled_coil"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009012">
        <property type="entry name" value="GrpE_head"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21237">
        <property type="entry name" value="PTHR21237"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01025">
        <property type="entry name" value="GrpE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00773">
        <property type="entry name" value="GRPEPROTEIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51064">
        <property type="entry name" value="SSF51064"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58014">
        <property type="entry name" value="SSF58014"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01071">
        <property type="entry name" value="GRPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 4" id="KW-0143">Chaperone</keyword>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0346">Stress response</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="150"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="17"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="150"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000639"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PJN05596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="188" mass="20911" checksum="D3742D847A4D4B38" modified="2018-04-25" version="1">MEKEQLQLTDPELRRLVEERTADLQRVKAEYDNYRKQVRRDRMAVREIAVANVLRALLPVLDTVDGACAHEPTTPGLKEVTETLRAHLGSLGLQSFGEAGDEFDPVCHEAVTHHVSPEAHRLFCSQILSPGYRLGDRLLRAAYVEVTGPRPERNHEGAEGRAIGERDSELPSRPRAGPGDHSRPLALG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JFP1</accession>
    <name>A0A2M9JFP1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MarR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_43025</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000042">
        <property type="protein sequence ID" value="PJN05706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN05706">
        <property type="protein sequence ID" value="PJN05706"/>
        <property type="gene ID" value="CG723_43025"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000835">
        <property type="entry name" value="HTH_MarR-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12802">
        <property type="entry name" value="MarR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00598">
        <property type="entry name" value="HTHMARR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00347">
        <property type="entry name" value="HTH_MARR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50995">
        <property type="entry name" value="HTH_MARR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH marR-type" evidence="1">
        <location>
            <begin position="30"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN05706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="178" mass="20090" checksum="4347619AEE0D249D" modified="2018-04-25" version="1">MTERKAARRDAVAEVIEDWARERPELDTTPLEVLARLHRSFLRYNTKLIASIERHGLSVAGFDVLTALRRSGEPYRLTAGQLADQGLVSSAGVTLRIDRLEKDGLIVRERDAGDRRVVYSRLTDEGLAKVDEVFTEHLDNERRMLGELSPAERRQLARLLRKLENSILASDTPDEAAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JG36</accession>
    <name>A0A2M9JG36_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">CTP synthase</fullName>
            <ecNumber evidence="9">6.3.4.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Cytidine 5'-triphosphate synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Cytidine triphosphate synthetase</fullName>
            <shortName evidence="9">CTP synthetase</shortName>
            <shortName evidence="9">CTPS</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">UTP--ammonia ligase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">pyrG</name>
        <name evidence="12" type="ORF">CG723_42905</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">CB01635</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>ATP + H2O + L-glutamine + UTP = ADP + CTP + 2 H(+) + L-glutamate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:26426"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.4.2"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>ATP + NH4(+) + UTP = ADP + CTP + 2 H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:16597"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>H2O + L-glutamine = L-glutamate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:15889"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
        </reaction>
    </comment>
    <comment type="activity regulation">
        <text evidence="9">Allosterically activated by GTP, when glutamine is the substrate; GTP has no effect on the reaction when ammonia is the substrate. The allosteric effector GTP functions by stabilizing the protein conformation that binds the tetrahedral intermediate(s) formed during glutamine hydrolysis. Inhibited by the product CTP, via allosteric rather than competitive inhibition.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 9">Pyrimidine metabolism; CTP biosynthesis via de novo pathway; CTP from UDP: step 2/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Homotetramer.</text>
    </comment>
    <comment type="miscellaneous">
        <text evidence="9">CTPSs have evolved a hybrid strategy for distinguishing between UTP and CTP. The overlapping regions of the product feedback inhibitory and substrate sites recognize a common feature in both compounds, the triphosphate moiety. To differentiate isosteric substrate and product pyrimidine rings, an additional pocket far from the expected kinase/ligase catalytic site, specifically recognizes the cytosine and ribose portions of the product inhibitor.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the CTP synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.2" evidence="9"/>
    <dbReference type="EMBL" id="NNBL01000041">
        <property type="protein sequence ID" value="PJN05783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN05783">
        <property type="protein sequence ID" value="PJN05783"/>
        <property type="gene ID" value="CG723_42905"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00159">
        <property type="reaction ID" value="UER00277"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003883">
        <property type="term" value="F:CTP synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044210">
        <property type="term" value="P:'de novo' CTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03113">
        <property type="entry name" value="CTPS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01746">
        <property type="entry name" value="GATase1_CTP_Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01227">
        <property type="entry name" value="PyrG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004468">
        <property type="entry name" value="CTP_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017456">
        <property type="entry name" value="CTP_synthase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017926">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033828">
        <property type="entry name" value="GATase1_CTP_Synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11550">
        <property type="entry name" value="PTHR11550"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06418">
        <property type="entry name" value="CTP_synth_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00117">
        <property type="entry name" value="GATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00337">
        <property type="entry name" value="PyrG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 9" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="4 9" id="KW-0436">Ligase</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8 9" id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CTP_synth_N" evidence="11">
        <location>
            <begin position="9"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="domain" description="GATase" evidence="10">
        <location>
            <begin position="307"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="region of interest" description="Amidoligase domain" evidence="9">
        <location>
            <begin position="1"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="region of interest" description="L-glutamine binding" evidence="9">
        <location>
            <begin position="388"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile; for glutamine hydrolysis" evidence="9">
        <location>
            <position position="387"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="521"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="523"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="19"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="20"/>
            <end position="25"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="77"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="146"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="153"/>
            <end position="155"/>
        </location>
        <ligand>
            <name>CTP</name>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
            <note>allosteric inhibitor</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="193"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="229"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="247"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="360"/>
        </location>
        <ligand>
            <name>L-glutamine</name>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="411"/>
        </location>
        <ligand>
            <name>L-glutamine</name>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="473"/>
        </location>
        <ligand>
            <name>L-glutamine</name>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF06418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PJN05783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="557" mass="60696" checksum="CECDEFA4C89B6479" modified="2018-04-25" version="1">MTPKSTTTKHIFVTGGVASSLGKGLTASSLGALLKARGLRVTMQKLDPYLNVDPGTMNPFQHGEVFVTNDGAETDLDIGHYERFLDVDLDGTANVTTGQVYSQVIAKERRGEYLGDTVQVIPHITNEIKHRIRRMATDDVDVVITEVGGTVGDIESLPFLETVRQVRHEVGRDNVFVVHISLLPYIGPSGELKTKPTQHSVAALRNIGIQPDAIVLRADREVPTAIKRKISLMCDVDEAAVVAAIDAPSIYDIPKVLHTEGLDAYVVRKLDLPFRDVDWTTWDDLLDRVHNPDHEIVMALVGKYIDLPDAYLSVTEALRAGGFANKARVKIKWVASDDCKTASGAKKQLGDVDAICIPGGFGDRGVSGKVGAIQYARENKIPLLGLCLGLQCIVIEAARNLADIPDANSTEFDAATAHPVISTMAEQLDIVAGEGDMGGTMRLGMYPAKLAEGSIAREVYDGKEYVEERHRHRYEVNNSYRAELEKKAGLQFSGTSPDGKLVEYVEYPREVHPYLVATQAHPELRSRPTRPHPLFAGLVKAAVERKTGGAANGKKAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JG71</accession>
    <name>A0A2M9JG71_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Glycosyl transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CG723_42410</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CB01635</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CDP-glycerol glycerophosphotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000039">
        <property type="protein sequence ID" value="PJN05890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN05890">
        <property type="protein sequence ID" value="PJN05890"/>
        <property type="gene ID" value="CG723_42410"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047355">
        <property type="term" value="F:CDP-glycerol glycerophosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019350">
        <property type="term" value="P:teichoic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12580">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007554">
        <property type="entry name" value="Glycerophosphate_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043148">
        <property type="entry name" value="TagF_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043149">
        <property type="entry name" value="TagF_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04464">
        <property type="entry name" value="Glyphos_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0777">Teichoic acid biosynthesis</keyword>
    <keyword evidence="3 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_2-like" evidence="7">
        <location>
            <begin position="5"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="718"/>
            <end position="739"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022944"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PJN05890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="739" mass="83676" checksum="AF88435BD71441EB" modified="2018-04-25" version="1">MPRFSVIVPVYKVQAYLHACLESVLEQSCSDLEVIAVDDCSPDASGAIADEFAARDKRVRTVRLPENVGLGRARNAGLEHATGDYVLFLDSDDTLTPGALQAITDRIEETGGPDVLVYDYARTYWTGEAVRNQYADRLTQDGPAPFALVDRPEILQLLMVVWNKAYRRAFIEEQGFTFPPGYYEDTPWTYPVLMSARTIATLDRVCVHYRQRRRGNILGTTSRAHFDVFEQYDRVFAFLDAHPDLASVWRPLLFRRMVEHFATVFTNPDRLARGTRPDFLRRARAHYRRYRVPGAPVAARDRLRHGLVRLGSHRTYRSLAAAMRFVRRVRGFTDRVRRTARAAVLQAHYRVQLRLPVRADRAVFSSYWGRGYGCNPGALEAAFRAHAPHVATAWIAGPEHHHTLPSGTRALSPGTAAYWTALARSKYLVNNVNFDRRLVKRPGQVLIQTQHGTPLKKMGLDLQDHPAAARGQDFDQLLRSVDTWDYVLSANRHSTLVWERVYPSAYTTLEYGYPRNDAFHRASSRDMARIRESLGIPEGATAILYAPTHRDYRRTQRCALDLERVLRRLGTDFVVLTRAHPLHQAPFAQGTGRVVDVSDHPSVESLCLAADALVTDYSSLMFDYANLDRPIVIHADDWEAYEASRGTYFDLRTSPPGAVARSEDELIDIFTTGHWRGSRSAQLRAAFRERFCPYDDGRAAERVVRHVVLGEDEAARSVREVPLAGPRPEPADERVGPRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JG73</accession>
    <name>A0A2M9JG73_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Methyltransferase type 11</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_42385</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000039">
        <property type="protein sequence ID" value="PJN05885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN05885">
        <property type="protein sequence ID" value="PJN05885"/>
        <property type="gene ID" value="CG723_42385"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransf_11" evidence="1">
        <location>
            <begin position="58"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN05885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="247" mass="27775" checksum="BFA40BD71DD929EE" modified="2018-04-25" version="1">MHQSAYEQMELCVRSYLPRGRRLRVVDLGARVSDGQVRTHKSLLEGYDTEYVGVDVLQGRNVDVVMAKPYRIPVRSNSADFLISGQAFEHIPFFWASMLEIARVLKPEGTAFITAPSRGHVHDAQDCWRYYPDGMRALAAYTRLELSEVYTDFPPMKGIRHAYGSIDAKHAYWGDTVGVFRKPAKYPRLTMALVRSTTRWWANRVGGVDGVPLPTPLAGRERCGRPAAVPRPAGVSNGEKRLLVDEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-09-29" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JG83</accession>
    <name>A0A2M9JG83_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Competence protein F phosphoribosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_42235</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000039">
        <property type="protein sequence ID" value="PJN05895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN05895">
        <property type="protein sequence ID" value="PJN05895"/>
        <property type="gene ID" value="CG723_42235"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="SSF53271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="98"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="133"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="179"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN05895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="348" mass="35633" checksum="F64F3EF5884E677F" modified="2018-04-25" version="1">MRGWLQDLGDLVLPAECGGCGRPRTTLCARCGDALCGGAPRRVRPNPEPPGLPVVHAAAPYQDAVRAVLLAHKERGALGLAEPLGAALAGAVRAGLGEAGDGGGGGGGGPVDRRTRTAGRPQVDAHTPRDMRTQTGGVRTPVSARPQPGARTQPTARTQPGARPPSTARTQPGARPQPTARTQPTPPPPPPTPLLLIPVPSARKAVRARGHDPSRRIAYAAAAELRRVGVPARVCAALRQRRVVADQAGLNSRRRLANLAGALEVPAGARALLATGGRIVLVDDVMTTGASLAEAARAIRAAVAGTAGGESDGITPRWVETARELPARNSISAAVVAASPSSFEINRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JGD0</accession>
    <name>A0A2M9JGD0_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">PMT_2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CG723_42370</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CB01635</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000039">
        <property type="protein sequence ID" value="PJN05883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN05883">
        <property type="protein sequence ID" value="PJN05883"/>
        <property type="gene ID" value="CG723_42370"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038731">
        <property type="entry name" value="RgtA/B/C-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13231">
        <property type="entry name" value="PMT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="71"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="100"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="124"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="154"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="186"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="262"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="294"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="325"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="domain" description="PMT_2" evidence="10">
        <location>
            <begin position="66"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="488"/>
            <end position="512"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF13231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PJN05883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="512" mass="54550" checksum="B938EE1767CBE107" modified="2018-04-25" version="1">MTAVLLPGLVMVGLGLWGLDRGTIWRDEAATMLVATRSLPQIHHLLGNIDAVHGLYYVLIHFVLGGQTDAYLMRLPSVFGAAAAACLVAALGIRLVRPRVGLWAGLLYAASPFTGYYAQEGRSYAIVAAGAAAATLMLVHCVRHPSWPAWAGYAALVTVTAWLHEFAVLVLAAHAVTLLVSRAAPVLWRGWASAATAAVLLVLPLADEARGQSFQVAWIRRPGWEDAEALLRLAAGHPGAVFNTTLLLAAAAVLAPSVRRGACGLVAVALPLAVVPPALLLTVSQWQPLYAPRYTFFAFAGLPLLVAAGADAVLRRLPGRVRPSWYIQVTAGAVLVAVAFWVQFPAQLRERSPEGRRDDFGAVARMAERDLRPGDALLYVPKTGRRLTETYPRAVAGVRDVSLKSSGARSGTLYGVDASPAELRARMACLSRVWVLFDAEAGHPGWHTRNPVELTKLALLKRDFMPLAESRRRSGLLRLYERVGGPAPTCAASAGPPAGATAAPTEPTLESP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JGI7</accession>
    <name>A0A2M9JGI7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CG723_42280</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000039">
        <property type="protein sequence ID" value="PJN05867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN05867">
        <property type="protein sequence ID" value="PJN05867"/>
        <property type="gene ID" value="CG723_42280"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041492">
        <property type="entry name" value="HAD_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023198">
        <property type="entry name" value="PGP-like_dom2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13419">
        <property type="entry name" value="HAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PJN05867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="224" mass="23875" checksum="60C51F0086CB2AAC" modified="2018-04-25" version="1">MGKHAAGAHIVWDWNGTLFHDNDAVISATNAAFAEIGLEPITLERYRELYCVPIPRFYQRLMGRLPTEAEWERMDTAFQRHYTLHRTACGLADGAELLLADWSAAGRSQSILSMYGHDELVPLVREFGIESHFLRVDGRTGPSGGSKAEHMVRHLGALAGAGVAPGRTVVIGDAADDAVAALHAGARAVLYTGGSHSRASLEGAGAPVVDTLAEAVGVAEHLAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JGX8</accession>
    <name>A0A2M9JGX8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DNA methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CG723_41015</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000035">
        <property type="protein sequence ID" value="PJN06125.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN06125">
        <property type="protein sequence ID" value="PJN06125"/>
        <property type="gene ID" value="CG723_41015"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044260">
        <property type="term" value="P:cellular macromolecule metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043412">
        <property type="term" value="P:macromolecule modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006807">
        <property type="term" value="P:nitrogen compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044238">
        <property type="term" value="P:primary metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002052">
        <property type="entry name" value="DNA_methylase_N6_adenine_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00092">
        <property type="entry name" value="N6_MTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PJN06125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="919" mass="100032" checksum="F68D34CDB271AF31" modified="2018-04-25" version="1">MTSDPGRILIDSWFPCAAVDEACGNRAGSGQVEKAIFTWFASRPIAQARAAVATALLPDEPDTRPLIDDAVRGNPGAVAKVAALVAERYPEGRPIVLDVFSGRGIISLEAARLGAKAVGLDLSPVATLAGRILADYPMRDWSGEPPLRWTHSQEASATLFEEDGTPRLIADLKVFLDEIGQRVQEAVEPYYPRNPDGSFPWGYLWAISITCDGCERRFPLLGSLVLRHPYARTKDAGQALRLVVDGDAWRAEVVDGLPDQAPTYSSTDLGDGRKRKGKSARCLFCSHVHSLETVKAKGAAAEYRDEVLLAIDTEGEAKRVFRTLRQDERTAARGVDTTALEDSGPLSAVPDEPIPAGNVHTVMASGYGYRTFGDLMCDRQALQFAETVRAIRSCHNDVLAAGVSPDYARALTAFASATVARRLRYSTRGCRVQAMGKGNGAEQNRIKVSDLFANEASLNFQFDWVETGPGSGPGTWASVSKTGLGPYLAHVRALQGSAARFRQANAMRLPYRDNSVDAVVTDPPYYDMIEYADASDLMHVWLKRILFDVEPDLFAPKAVRTRDGLQNKDDEIIVRRVHEPGRIRHDKDFYEASLSKAFQECRRVLRPDGHLVVVFGHSDPDAWKRLLAALHDAGFVVTSSWPSRTESANTGVASIKVTITIGCRVAPEGREAATAAQVDKEVADAIRSRVRGWTTDGLALADQMMAAYGPAMEVYGRHSAVIQPDGETAPLERYLTLARRCVREATALRLDRIPIETFDAITRFAVFWMRVHGRTVVPKGEALFLAQVDSLRLEDVRGDLLAETRKGFRLVLDPPASISPDSAEFDVARALAGAYAVGGTEAASAVLAKWERPVDDEHLWAVIGDLAAQLPPSDAIAKSLVALQRNTSAIKNLARGLAGALAQSAPMRSPTLFDVEEAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JH22</accession>
    <name>A0A2M9JH22_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">PrpF, AcnD-accessory</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_40615</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PrpF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000034">
        <property type="protein sequence ID" value="PJN06179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN06179">
        <property type="protein sequence ID" value="PJN06179"/>
        <property type="gene ID" value="CG723_40615"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007400">
        <property type="entry name" value="PrpF_protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43709">
        <property type="entry name" value="PTHR43709"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04303">
        <property type="entry name" value="PrpF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN06179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="380" mass="38644" checksum="BCB81B536048CD61" modified="2018-04-25" version="1">MHVPATLVRGGTSKCWLFPQVHMPTDRDRIERILVDAYGAADPVQLDGIGGATPTTSKAAVVGVSSREGVDIDYLFAQVGIGTGTVEWGSNCGNCATAIALYAVAEGLVPLKGDRTPVVMRHINTGAVLEAEVDTPGGRVQEFGDRTVPGTLAGGVPVGLAFRDPAGATTGHLLPTGLPAQELPVGELAGGARIPKSGAPLIVSMLDAGAPVVLVDAVRAGRTGAETLDQMRAEASWLRATRHAAAVRMGLVQPRAEPGDAVPKTGLIGPPVAYTTTLGEHVAAHEYDVSVRMLSMNSPHPAIGLTSAVAVAAANLVEGTVVANASTAPGGRVLRIGTPAGVLAVESSGAGPDRVTVARAARILCQARILVRDLALPAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JHE1</accession>
    <name>A0A2M9JHE1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Non-ribosomal peptide synthetase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CG723_39855</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CB01635</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Antibiotic biosynthesis.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000032">
        <property type="protein sequence ID" value="PJN06300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN06300">
        <property type="protein sequence ID" value="PJN06300"/>
        <property type="gene ID" value="CG723_39855"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00031">
        <property type="reaction ID" value="UER00014"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017000">
        <property type="term" value="P:antibiotic biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008610">
        <property type="term" value="P:lipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901362">
        <property type="term" value="P:organic cyclic compound biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030639">
        <property type="term" value="P:polyketide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010071">
        <property type="entry name" value="AA_adenyl_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001242">
        <property type="entry name" value="Condensatn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010060">
        <property type="entry name" value="NRPS_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00668">
        <property type="entry name" value="Condensation"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="SSF47336"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01733">
        <property type="entry name" value="AA-adenyl-dom"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01720">
        <property type="entry name" value="NRPS-para261"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="5">
        <location>
            <begin position="949"/>
            <end position="1024"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="5">
        <location>
            <begin position="2011"/>
            <end position="2085"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="4">
        <location>
            <position position="984"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="4">
        <location>
            <position position="2046"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PJN06300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="2596" mass="276835" checksum="0ABB4E5447700CB1" modified="2018-04-25" version="1">MSVPVPDGTRLPLTAAQLGIWFAQARDPHSPVYNTGEYVELTGPLDADRFERALRDVIARTDALRLRFHPEADGTVTQSADADPSFTVHRIDVSASPDPAAAADAWMRDVIARPLDAAGGGPLFTQALFKLGEGSHRWFSHVHHLLIDGYGFRLVAERVARAYTGAAAGPDCSARELTDAEAAWRDSPAHDRDRAHWLAAPRRTPVTLAGSTAPAAPHARRHTAFVGRDVLAGLTAVAAAAETGWQVVAPAAVAAYVQWLTGEPGITLGMPVTARLTPAARRTPGMVANVLPLYVAPRPAAPLTELVADVRDALVPVLRHQRYPYEEARRDLGLVGERGYGPVVNVMPYQRALDFGEAAASVHPVSTGPVDDLKFSVYEEPGDTGLRIDVEANPDLYGEAETAAHLERFTRFLRALAAADPDTPLARLHAGETPADGDPQEAAATGTLHARFAARAAATPDAVAVSHEGDHLTYAELDARANRLAHRLVAAGAGPERLVALTLPRSPDLVVALLAVLKSGAAYLPLDPDYPADRRTWMLEDARPVLVLDPEAMRQDLSAYPDTDPGVRADASHPAYVIYTSGSTGRPKGVVIPHANVLRLFSATGRWFDFGADDVWTLFHSYAFDFSVWEIWGALLHGGRLVVVPYTVSRSPDRFLDLLARERVTVLSQTPTAFHQLDTADRERGADAPELALRQVVFGGEALEPARLANWYARRGADAARLVNMYGITETTVHVTCAPLGPEHAVPGARSFVGGPLTDLRTRVLDAALRPVPAGFTGELYVSGPGLARGYLGRPDLTADRFVADPYGPPGTRMYRTGDLVRLLDDGTFDYLGRGDHQVKIRGFRIELGEIESALVAHPGVAEAAVVVREDRPGDKRLAAYAVPATGHTPDPADWRRLLAATLPAHCVPASFTPLDALPLTANGKLDRAVLPAPAAPDEPREAAAPAAGPEEEALRRIFADVLGVGDTARVGGDSDFFTLGGHSLLAGRLIGAVREALGAEITIQDLFEAPTPAGLAARVAGAARAARPPLRPAAHGDEPPMSYAQHRMWVLREVEGAAPTYNMPIALRITGALNRIALREALHDLVTRHESLRTVYPRGERGAAPRLLPPEEARPWVIESRIEPERLPDELTAAARTPFNLDCQLPIRAYLFTLPDGDNVLLLLMHHVAGDGWSLRPLLGDLSAAYASRLAGHAPGLPPLPVSYADFALWQRDLLGDERDPGSLAGRQLAYWERNLAGAPDQLELLADRPRPPVAEHRGGSVPLDIAPALHARIDAFARTHGSTCHMVLQATLTALLSRLGAGTDISIGCPTASRPDSALDALVGFFVNPVVLRTDTSGDPSFTELLARVRTAALAAYAHQDVPFDRVVERLQPERSAARHPLFQVVLSYQDFEAPAELRGVEVRREPVDFGVAKFDLTFNVVEHRTGAGEFAGIDGDLEYDVALYDRATAETVVRRFLALLDAAVAAPDTPVGAHELLDATESALLAHFNDTARPVPATGLAEQFAAQAARTPDAVAVVGDDGTELTYAELDLRSGRLARRLAASGIGRESAVAVLQQRSADLVVSLLAVLRTGGFYVPLNTRYPAARMSLITGDVGARVLLTDRVTDAEHACASWAGDAEVLVVDALPDEGDALPVVPAHPHQLAYVMYTSGSTGNPKGVAITHGDVGVLAADHCWRTGNQERVLLHSPYSFDTSQYELWVPLLSGGAVVVAPPGDLDTRALERAIVDGRVTGMWLTSGLFNLLAEESPGCFTGVREVWTGGDVVSPAAVSRVLAASPTTMVVDGYGPTEATTFATHHFMRAPWEQESTVPIGTPLDNTTCHVLDDLLRPVPPGVSGELYIGGARLARGYLKRPDATSERFVADPFAAAPGARMYRTGDLVRRRPDGILEFLGRADHQVKVRGFRIELGEIESVLGAHPRVAQCAVLVREDGSVANNAKRLVAYVVAAPGADVDASVLRQHVAAALPDYMVPAAFVGLDALPLTANGKLDRRSLPAPDFGAAESAGRAPRTPREELLAVLFAEVLGADGVSIDDSFFDRGGDSIMVIQLVGKARRAGLSLTATQVFEHKTVAALAGVAETLAEEPAPPGQGALASAATGDVPLTPIMHWLRERGGPVEAFSQSMVVAVPAELDEARLVAALRTLIDHHDVLRAVFTRDGDSWSMRIDAPGGAHAEDWVRRVDAAGLDDAALRALAAEEAAAARDRLDPFAGRNGRAVWLDAGPGRPGRLLLTLHHLVVDGVSWRILLPDLKAAWEATEPGVTGSLPPVGTPFRAWARYLAEEAARPERTAELALWTRTLAGGAAPVTTQPLDPGLDTAATARSLSIDLDGATTSALLTTVTAAFNGRVDDVLLTAFALAVADWRRRRGLGDVDAVLIDLEGHGREPGGSGAELSRTVGWFTSMYPVRLAPGALDRADALAGGPAAGQAVKRIKEQLREISDGGIGHGLLRHLDVRTGRSLAALARHGTPDLGFNYLGRFLGEEGGLWTAAPDADAIGDGTDADLPLAHAVEVNALTRDGSSGPRLQAVWTWAGRLLDEAAVRDLGETWFRALKALVTHAERPDAGGITPSDLSLVSLSQDQIDQLEAAWKVAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JHJ7</accession>
    <name>A0A2M9JHJ7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_39530</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000031">
        <property type="protein sequence ID" value="PJN06356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN06356">
        <property type="protein sequence ID" value="PJN06356"/>
        <property type="gene ID" value="CG723_39530"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="66"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN06356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="99" mass="10963" checksum="671800347F539AF8" modified="2018-04-25" version="1">MEFPGPRRCHDRRNRALRPGGLRLAATPEGRRRLDGGIRLVATPLAVLVLSYYGEFGPLDHPPLPGPYDLLTLVALSLACYTWALHSGCRTQQLDRTIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JI51</accession>
    <name>A0A2M9JI51_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PadR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_38200</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000028">
        <property type="protein sequence ID" value="PJN06540.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN06540">
        <property type="protein sequence ID" value="PJN06540"/>
        <property type="gene ID" value="CG723_38200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005149">
        <property type="entry name" value="Tscrpt_reg_PadR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03551">
        <property type="entry name" value="PadR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PadR" evidence="1">
        <location>
            <begin position="7"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN06540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="175" mass="19686" checksum="968A79282E759C18" modified="2018-04-25" version="1">MSIGHTLLGLLESGPRHGYDLKRTFDATFGHDKPLHYGQVYSTMSRLLKNGLVEVDGIEAGGGPERKRYAITDAGITDVQRWLATPEAPEPYLQSVLYTKVVLALLTERDAVTVLDAQRAEHLRMMRILTDRKRKGDLADQLICDHALFHLEADLRWLELTAARLDKLAAEVRKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JIE4</accession>
    <name>A0A2M9JIE4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF402 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_37775</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000027">
        <property type="protein sequence ID" value="PJN06638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN06638">
        <property type="protein sequence ID" value="PJN06638"/>
        <property type="gene ID" value="CG723_37775"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.380.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007295">
        <property type="entry name" value="DUF402"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035930">
        <property type="entry name" value="FomD-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04167">
        <property type="entry name" value="DUF402"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF159234">
        <property type="entry name" value="SSF159234"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF402" evidence="1">
        <location>
            <begin position="62"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN06638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="166" mass="18238" checksum="AB5EFF21F8CAF021" modified="2018-04-25" version="1">MSAPSPDPAEALDVVLVKAGRLKIRYPADVVRDDGTRVTVTAAWASPGVRDFGFVQFGPGDVFTEHYWRDRWYAVKEVRTGGGTFKGWYCDVTRPAVREGGELRVEDLDLDLWVSADGSDVLRLDEDEFAESGLAERDPHAAAAAVRALDDLELLARTEGFGRLLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-05-25" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JIK0</accession>
    <name>A0A2M9JIK0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">LacI family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CG723_38130</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000027">
        <property type="protein sequence ID" value="PJN06694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN06694">
        <property type="protein sequence ID" value="PJN06694"/>
        <property type="gene ID" value="CG723_38130"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01392">
        <property type="entry name" value="HTH_LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000843">
        <property type="entry name" value="HTH_LacI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046335">
        <property type="entry name" value="LacI/GalR-like_sensor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00356">
        <property type="entry name" value="LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13377">
        <property type="entry name" value="Peripla_BP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00354">
        <property type="entry name" value="HTH_LACI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50932">
        <property type="entry name" value="HTH_LACI_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014902916" evidence="4">
        <location>
            <begin position="19"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="domain" description="HTH lacI-type" evidence="5">
        <location>
            <begin position="10"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PJN06694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="345" mass="36204" checksum="35D56D6F8DB54284" modified="2018-04-25" version="1">MSKARTGSRPTIKAVAAAAGVSTAAVSQAFNDKGRLAEPTRRRILDAAAELGWSPSASAAALRSARTRTLALVVRRPTDVLGADPHFSELITGIEGELAPRGYGLLLHLVAGVDEESALYERLAAEGRVDGAVLTDARADDPRPALLRRIGLPSVLLGAPDPEATVPTVGLGNQGSGVHEAVDHLLGLGHRRIAYVCGPTELQHTRLRRTVFEETLGLAGLRPVAVLSTDFSEGAAVAATEELIGRTERPTAIVYANDSMAVCGIGTAQRAGLRVPEDLSVVGYDNLPLGSWLHPRLTTVDQQVQRVGAAAARVLLARCGEDVPETPLEGRPHLVVRESTGPATP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JIR2</accession>
    <name>A0A2M9JIR2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Serine/threonine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_37395</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000026">
        <property type="protein sequence ID" value="PJN06758.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN06758">
        <property type="protein sequence ID" value="PJN06758"/>
        <property type="gene ID" value="CG723_37395"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005543">
        <property type="entry name" value="PASTA_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03793">
        <property type="entry name" value="PASTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51178">
        <property type="entry name" value="PASTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PASTA" evidence="2">
        <location>
            <begin position="6"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="77"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN06758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="113" mass="12069" checksum="A7CFB7797209FA13" modified="2018-04-25" version="1">MRITPKTPEVRVPKFVGLMAVDAREAAAARGVQLAAPDRPDFRLTVVDYVVRQYPLPDTEVPRGAVVTVWFDLADGEGHGGSGVNEPRMPGPRGGGLQRELDEPGGTYSVVGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JIS8</accession>
    <name>A0A2M9JIS8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_37520</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000026">
        <property type="protein sequence ID" value="PJN06779.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN06779">
        <property type="protein sequence ID" value="PJN06779"/>
        <property type="gene ID" value="CG723_37520"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyr_redox_2" evidence="1">
        <location>
            <begin position="4"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN06779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="400" mass="42751" checksum="81A2F02CDC3ECEC0" modified="2018-04-25" version="1">MIHPVAVIGAGPYGLSTAAHLRARGIPVRVFGEPMVSWRSHMPAGMLLKSVPSASNIDAPQRGHDLVDYCDAAGIPRLVTDEDIVPVETFVAYGDWFQQKLVPDLERVRVVSVDRRGHENFEVKLDSGEQFTARAVVVATGLSGLDHLPHELAAAAPDGPAPTGPVSHSSQHHDLSRFSGRELIVVGAGQSALETAALAAEAGASVRIVARGTGSVRFGAPPWGQPKLRPETPFGRAWSLYALTYYPHPYRHLPPQARHFLVRRVLGPLGAWWLRERFEDKVRVREVEAIVGSAAADGGAALAVRAPGGRREELTADHVIAATGYRVDLAAMDFLGDGLRTRIAASRGTPKLGTGYVSSVPGLYFTGMLGGSSFGPVMRFVCGTEFASPRLVKHLAAAHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JIW9</accession>
    <name>A0A2M9JIW9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_36685</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000025">
        <property type="protein sequence ID" value="PJN06824.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN06824">
        <property type="protein sequence ID" value="PJN06824"/>
        <property type="gene ID" value="CG723_36685"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007436">
        <property type="entry name" value="DUF485"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04341">
        <property type="entry name" value="DUF485"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="113"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="144"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="54"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN06824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="199" mass="22296" checksum="D0CDF7BA9FBD673E" modified="2018-04-25" version="1">MSDTPHRSYSDHQNEPWQGPFPTGQSQYGNQNRNQYGNPSQGPYGNQYPGEHQQPYPRQPPHPRQQPDPALTYPWAPAPPPPAPTHRLPRHPALGHHSDLRLLRSAYRWQRRVATLTALGYFTLFLVLSAFAPSLMTGTLPGGFSTGLLLGLCQLPVTALALWLYEYTARRRVDPLAHRLRRQAELDRPAPGTAGGNSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JIX9</accession>
    <name>A0A2M9JIX9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Nucleoside triphosphate pyrophosphohydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_36750</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000025">
        <property type="protein sequence ID" value="PJN06835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN06835">
        <property type="protein sequence ID" value="PJN06835"/>
        <property type="gene ID" value="CG723_36750"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004518">
        <property type="entry name" value="MazG_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011551">
        <property type="entry name" value="NTP_PyrPHydrolase_MazG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30522">
        <property type="entry name" value="PTHR30522"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03819">
        <property type="entry name" value="MazG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MazG" evidence="1">
        <location>
            <begin position="147"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN06835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="330" mass="35053" checksum="CB8C169EA15BEC8D" modified="2018-04-25" version="1">MNAENAPTAAPTGRIVLLTTSHRVAPGLLSWSAWQLLHAADEVLCADAAHPQLPYLREAGIEVREAAPTASELVDACAGGRTVVVVATAEGDRRLTDGLAALAGSGRVAMPDLELLPASYDLPGARLLDLVQVMDRIRRECPWSSQQTHKGLAKYAIEEAYELVEAIEDGDRDELREELGDVLLQVVFHARIAEEASGEEGDEAFSVDDVAGGIVEKLIHRHPHVFGDDTALTPEDVKEHWLRTKAVEKQRESVTDGVPVGQPGLALAAKLGSRVRTAGLDVPAPGGDGVGYELLALALRAESDGVDPEAALRAAARAYRDAIRAAEGLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JJ66</accession>
    <name>A0A2M9JJ66_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Allantoate amidohydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CG723_36925</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CB01635</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="2">Binds 2 Zn(2+) ions per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M20 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000025">
        <property type="protein sequence ID" value="PJN06914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN06914">
        <property type="protein sequence ID" value="PJN06914"/>
        <property type="gene ID" value="CG723_36925"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016813">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010158">
        <property type="entry name" value="Amidase_Cbmase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036264">
        <property type="entry name" value="Bact_exopeptidase_dim_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002933">
        <property type="entry name" value="Peptidase_M20"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32494">
        <property type="entry name" value="PTHR32494"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01546">
        <property type="entry name" value="Peptidase_M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001235">
        <property type="entry name" value="Amidase_carbamoylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55031">
        <property type="entry name" value="SSF55031"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01879">
        <property type="entry name" value="hydantase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="binding site" evidence="2">
        <location>
            <position position="70"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="81"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="116"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="181"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="206"/>
        </location>
        <ligand>
            <name>allantoate</name>
            <dbReference type="ChEBI" id="CHEBI:17536"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="264"/>
        </location>
        <ligand>
            <name>allantoate</name>
            <dbReference type="ChEBI" id="CHEBI:17536"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="277"/>
        </location>
        <ligand>
            <name>allantoate</name>
            <dbReference type="ChEBI" id="CHEBI:17536"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="372"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR001235-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR001235-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PJN06914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="400" mass="42691" checksum="CD50C033E6B65089" modified="2018-04-25" version="1">MWRDLAPIGRNNESGGYRRYAWTAADTDCRAWFKAQAESRGLTYELDRNGNQWAWLGDPAAGDAVVTGSHLDSVPDGGAFDGPLGVVSSFAALDELRRRGAEFTRPLALTNFGDEEGARFGLACVGSRLTAGRLTPEQAAQLRDGDGVSLPQAMERAGYDPEAIGPDPERLARIGAFVELHVEQGRALDLSGDAVGVASAIWPHGRWRFDFRGEANHAGTTRLVDRRDPMLSYAQTVLAARREAELAGAVATFGKISVEPNGVNAIPSLVRGWLDSRAADQQTLDTVVTAVEKAAREYADAHGIDLETVRESFTPVVEFDHALRDELGRILGTDDKLTVPVLGTGAGHDAGILADSVPTAMLFVRNPTGVSHSPAEHAAEDDCLAGVNALADVLEGLACR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JJB3</accession>
    <name>A0A2M9JJB3_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1 4">Imidazolonepropionase</fullName>
            <ecNumber evidence="1 4">3.5.2.7</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Imidazolone-5-propionate hydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">hutI</name>
        <name evidence="6" type="ORF">CG723_36935</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CB01635</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Catalyzes the hydrolytic cleavage of the carbon-nitrogen bond in imidazolone-5-propanoate to yield N-formimidoyl-L-glutamate. It is the third step in the universal histidine degradation pathway.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>4-imidazolone-5-propanoate + H2O = N-formimidoyl-L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:23660"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:58928"/>
            <dbReference type="ChEBI" id="CHEBI:77893"/>
            <dbReference type="EC" id="3.5.2.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <cofactor evidence="4">
            <name>Fe(3+)</name>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
        </cofactor>
        <text evidence="4">Binds 1 zinc or iron ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4">Amino-acid degradation; L-histidine degradation into L-glutamate; N-formimidoyl-L-glutamate from L-histidine: step 3/3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the metallo-dependent hydrolases superfamily. HutI family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.2.7" evidence="1 4"/>
    <dbReference type="EMBL" id="NNBL01000025">
        <property type="protein sequence ID" value="PJN06867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN06867">
        <property type="protein sequence ID" value="PJN06867"/>
        <property type="gene ID" value="CG723_36935"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00379">
        <property type="reaction ID" value="UER00551"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050480">
        <property type="term" value="F:imidazolonepropionase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019556">
        <property type="term" value="P:histidine catabolic process to glutamate and formamide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019557">
        <property type="term" value="P:histidine catabolic process to glutamate and formate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00372">
        <property type="entry name" value="HutI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005920">
        <property type="entry name" value="HutI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42752">
        <property type="entry name" value="PTHR42752"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01979">
        <property type="entry name" value="Amidohydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="SSF51338"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01224">
        <property type="entry name" value="hutI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 4" id="KW-0369">Histidine metabolism</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 4" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Amidohydro-rel" evidence="5">
        <location>
            <begin position="62"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="70"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="72"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="79"/>
        </location>
        <ligand>
            <name>4-imidazolone-5-propanoate</name>
            <dbReference type="ChEBI" id="CHEBI:77893"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="137"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="164"/>
        </location>
        <ligand>
            <name>4-imidazolone-5-propanoate</name>
            <dbReference type="ChEBI" id="CHEBI:77893"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="227"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="230"/>
        </location>
        <ligand>
            <name>4-imidazolone-5-propanoate</name>
            <dbReference type="ChEBI" id="CHEBI:77893"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="301"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="303"/>
        </location>
        <ligand>
            <name>N-formimidoyl-L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:58928"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="305"/>
        </location>
        <ligand>
            <name>N-formimidoyl-L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:58928"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="306"/>
        </location>
        <ligand>
            <name>4-imidazolone-5-propanoate</name>
            <dbReference type="ChEBI" id="CHEBI:77893"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PJN06867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="389" mass="40779" checksum="DBE031F34F8D2E52" modified="2018-04-25" version="1">MTTTVITNIGSLVTNDPAQGDSPLGLVEHAAVVIEDDRIAWVGPQAQAPAADATHDAEGRAVIPGFVDSHSHLVFAGDRTQEFNARMSGRSYSAGGIRTTVAATRAATDAELEANLTHYLAEALRQGTTTFETKSGYGLTVEDEARALRIAARHTDEVTYLGAHIVSPDYADDPAAYVALVTGEMLDACAPHARWVDVFCEKGAFDGDQARAILKAGQARGLHPRVHANQLSYGPGVQLAVELDAASADHCTHLTDADVDALANGGTVATLLPGAEFSTRAEWPDARRLLDAGATVALSTDCNPGSSFTSSVPFCIALAVRDMGMTPDEAIWAATAGGARALRRDDIGRVAPGAYADLALLDAPSHVHLAYRPGVPLVSAVWRRGVRAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JJI2</accession>
    <name>A0A2M9JJI2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">IS5/IS1182 family transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_36660</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000024">
        <property type="protein sequence ID" value="PJN07012.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN07012">
        <property type="protein sequence ID" value="PJN07012"/>
        <property type="gene ID" value="CG723_36660"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025161">
        <property type="entry name" value="Put_IS4/IS5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002559">
        <property type="entry name" value="Transposase_11"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01609">
        <property type="entry name" value="DDE_Tnp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13340">
        <property type="entry name" value="DUF4096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDE_Tnp_1" evidence="1">
        <location>
            <begin position="79"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN07012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="259" mass="29020" checksum="97414352F2494D01" modified="2018-04-25" version="1">MPAHTVFGRPPEHDLRDIMDAILYVDRTGVQWRYLPHDFPHWNTVYGYFTKWQQEGVFAQLNGLLRQLLRQQEGRDAEPSACVIDAQSVKTSTSVHASSQGIDAGKKIVGRKRSIVTDTIGLLLAVLVTAASVQDSVAGTGLLDQVAAEHPGIRKAWVDGGYRQHLVEHAATLGIDMEISTRKPGLRGFTPIPKRWAVERTYGWLMLHRRLARDYETLPARSEAMIHIAMTDLMARRLTGENTISWRDPTPHTKQSIPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JJY3</accession>
    <name>A0A2M9JJY3_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 9">Biotin synthase</fullName>
            <ecNumber evidence="2 9">2.8.1.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">bioB</name>
        <name evidence="12" type="ORF">CG723_34845</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">CB01635</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8 9">
            <text>(4R,5S)-dethiobiotin + [sulfur carrier]-SH + 2 reduced [2Fe-2S]-[ferredoxin] + 2 S-adenosyl-L-methionine = 2 5'-deoxyadenosine + [sulfur carrier]-H + biotin + 2 L-methionine + 2 oxidized [2Fe-2S]-[ferredoxin]</text>
            <dbReference type="Rhea" id="RHEA:22060"/>
            <dbReference type="Rhea" id="RHEA-COMP:10000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10001"/>
            <dbReference type="Rhea" id="RHEA-COMP:14737"/>
            <dbReference type="Rhea" id="RHEA-COMP:14739"/>
            <dbReference type="ChEBI" id="CHEBI:17319"/>
            <dbReference type="ChEBI" id="CHEBI:29917"/>
            <dbReference type="ChEBI" id="CHEBI:33737"/>
            <dbReference type="ChEBI" id="CHEBI:33738"/>
            <dbReference type="ChEBI" id="CHEBI:57586"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:64428"/>
            <dbReference type="ChEBI" id="CHEBI:149473"/>
            <dbReference type="EC" id="2.8.1.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>2Fe-2S cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49601"/>
        </cofactor>
        <text evidence="9">Binds 1 [2Fe-2S] cluster. The cluster is coordinated with 3 cysteines and 1 arginine.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="9">Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 9">Cofactor biosynthesis; biotin biosynthesis; biotin from 7,8-diaminononanoate: step 2/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the radical SAM superfamily. Biotin synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.8.1.6" evidence="2 9"/>
    <dbReference type="EMBL" id="NNBL01000022">
        <property type="protein sequence ID" value="PJN07176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN07176">
        <property type="protein sequence ID" value="PJN07176"/>
        <property type="gene ID" value="CG723_34845"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00078">
        <property type="reaction ID" value="UER00162"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004076">
        <property type="term" value="F:biotin synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009102">
        <property type="term" value="P:biotin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01694">
        <property type="entry name" value="BioB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010722">
        <property type="entry name" value="BATS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002684">
        <property type="entry name" value="Biotin_synth/BioAB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaB/NifB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22976">
        <property type="entry name" value="PTHR22976"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06968">
        <property type="entry name" value="BATS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00876">
        <property type="entry name" value="BATS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00433">
        <property type="entry name" value="bioB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="3 9" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="9" id="KW-0093">Biotin biosynthesis</keyword>
    <keyword evidence="6 9" id="KW-0408">Iron</keyword>
    <keyword evidence="7 9" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="5 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Radical SAM core" evidence="11">
        <location>
            <begin position="47"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="328"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="353"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="65"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="69"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="72"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="109"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="142"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="202"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="272"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PJN07176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="405" mass="42695" checksum="4DF1D08F6DCA0C40" modified="2018-04-25" version="1">MDLLNTLVDKGLRRELPSREEALAVLATSDDELLDVVAAAGKVRRQWFGRRVKLNYLVNLKSGLCPEDCSYCSQRLGSKAEILKYTWLKPDEASKAAAAGVAGGAKRVCLVASGRGPTDRDVDRVSETIGAIKEQNEGVEVCACLGLLSEGQAERLRGAGADAYNHNLNTSEGTYGDITTTHTYADRVDTVQKAHAAGLSACSGLIAGMGESDEDLVDVVYSLRELDPDSVPVNFLIPFEGTPLAKEWNLTPQRCLRILAMVRFVCPDVEVRIAGGREVHLRSMQPLALHLANSIFLGDYLTSEGQAGKADLDMITDAGFEVEGTDQVTLPEHRGGPCGSEAAATRGSGAGSACGSGGGCGSHEEGGCGSHEDAAESPVAEVPEARTDLVAVRRRGAGTDLAPNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JK24</accession>
    <name>A0A2M9JK24_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alkylhydroperoxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_35465</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000023">
        <property type="protein sequence ID" value="PJN07137.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN07137">
        <property type="protein sequence ID" value="PJN07137"/>
        <property type="gene ID" value="CG723_35465"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004601">
        <property type="term" value="F:peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051920">
        <property type="term" value="F:peroxiredoxin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029032">
        <property type="entry name" value="AhpD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004675">
        <property type="entry name" value="AhpD_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003779">
        <property type="entry name" value="CMD-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02627">
        <property type="entry name" value="CMD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69118">
        <property type="entry name" value="SSF69118"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00778">
        <property type="entry name" value="ahpD_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CMD" evidence="1">
        <location>
            <begin position="20"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02627"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN07137.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="151" mass="16240" checksum="574564A5804ACF77" modified="2018-04-25" version="1">MQARMESPAQLIPGAMQPVLALLKATREGGVPGSTLELVHLRASQINGCSYCVDAGVRSARKGGESDDRLFAVAAWREAPYFTDAERAALALAEAVTRLADSTDPVPDAVWDEAARHYDERGLAALILMIGVTNLFNRFNVTTRQPAGASW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JK56</accession>
    <name>A0A2M9JK56_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_35250</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000022">
        <property type="protein sequence ID" value="PJN07248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN07248">
        <property type="protein sequence ID" value="PJN07248"/>
        <property type="gene ID" value="CG723_35250"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024747">
        <property type="entry name" value="Pyridox_Oxase-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12900">
        <property type="entry name" value="Pyridox_ox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN07248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="236" mass="25201" checksum="D4DB48C64971C302" modified="2018-04-25" version="1">MEFAMSVASEPGTVASGDASASYPATDRTVPARMRERTYYDRELVHSILDEAYICHLGFVRDGSPVVLPTLYGRVGETLYVHGSTGARVQRMAGAADPGLQVCLTVTHVDGLVLARSAFHHSLNYRSVVVHGLAHQVTDRDEKRTALDAIVDHVVPGRAQDSRPGNDKELAATSVLRLDLAEVSARVRAGGPNDDEEDLGLPYWTGVVPLTKGHGAPIPADDLAPGIAVPDYLTGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JL18</accession>
    <name>A0A2M9JL18_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="10">ABC transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CG723_32910</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000019">
        <property type="protein sequence ID" value="PJN07570.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN07570">
        <property type="protein sequence ID" value="PJN07570"/>
        <property type="gene ID" value="CG723_32910"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045454">
        <property type="term" value="P:cell redox homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042883">
        <property type="term" value="P:cysteine transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034775">
        <property type="term" value="P:glutathione transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014223">
        <property type="entry name" value="ABC_CydC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014216">
        <property type="entry name" value="ABC_transptr_CydD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221">
        <property type="entry name" value="PTHR24221"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="SSF90123"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02868">
        <property type="entry name" value="CydC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02857">
        <property type="entry name" value="CydD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="17"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="61"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="139"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="161"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="240"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="274"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="601"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="636"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="716"/>
            <end position="738"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="744"/>
            <end position="764"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="824"/>
            <end position="845"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="857"/>
            <end position="880"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="9">
        <location>
            <begin position="20"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="8">
        <location>
            <begin position="333"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="9">
        <location>
            <begin position="602"/>
            <end position="885"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="8">
        <location>
            <begin position="919"/>
            <end position="1154"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="367"/>
            <end position="374"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="953"/>
            <end position="960"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PJN07570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="1164" mass="122201" checksum="3C7D70896660BF3A" modified="2018-04-25" version="1">MKPIDQRLLRYARATRLFLIAVVVLGVAGAGLVIAQAMLIAEVVVGAFEHGLDVFALRTPLLLLALVAAGRGLVSWLTELAAHRASAAVKSELRGRLLERASQLGPGWLSGQRTGSLVALATRGVDALDDYFSRCLPQLGLAVVVPVAVLARIVTEDWVSAAIIVCTLPLIPVFMILIGWATQSHMDRQWRLLSRLSGHFLDVVAGLPTLKVFGRAKAQAESVRRITGEYRQATMRTLRIAFLSSFALELLSTLSVALVAVTIGMRLVHGDMDLYVGLVILVLAPEAYLPLRQVGAQYHAAAEGLAAAEEIFAVLETPVPPSGAGAVPAATGIAFDGVTVRYPGRSTDAVSEAGFDVAPGETVALVGPSGVGKSTLLSAALGFVRPDAGRVLVGGADLAGLDREAWHARVAWVPQRPQLYAGSVADNVRLARPDASSAEVEEALREAGAQDFVRALPDGADTLLGEDGAGLSAGQRQRLALARAFLADRPVVLLDEPTAALDGETEAGIVEAVRRLAAGRTVLLVVHRPALLAVADRVVRLDVPRSPAVAGEPAVRPVPSAEAADVPGYVEDRHVSDHSGESRGSVLARVRGAARARRGRLALALLLGALALGSAVGLMATSGWLISRASQQPPVMYLMVAVTATRAFGIGRACFRYAERVVSHDAVLRMLADTRVAVYRRLERLAPAGLRTTRRGDLLSRLVADVDALQDYWLRWLLPASAAAVVGAASVAFTAWMLPSAGAVLAAGLLLAGVGVPLLSGAVARRAERRLAPARGTLATRVAELLTGTAELTVSGALSARTAQAKAADSVLTRIASRAATATALGDGLTALITGLTVAGAALAGVQGVREGRLDGVQLAVVVLTPLAAFEAVMGLPLAVQYRQRVKKSAERVHEVLDATVPVREPEAPAQAPQDPFPLVVRGLAARHDGQGRDALHGVDLTLERGYRVAVVGSSGSGKTTLAQVLLRFLDAAEGSYTLAGQDAYGLEGDAVRRLVGLCAQDAHLFDSSVRENLLLAKKDATDDGLREVLAAARLLEWADSLPDGLGTLVGEHGARLSGGQRQRLALARALLADFPVLVLDEPAEHLDLPTADALTADLLSATEGRTTLLITHRMAGLDAVDEVIVLDAGRVVQRGRYEDLVAVEGPLRALWEREREAELLVGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-06-02" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JLF9</accession>
    <name>A0A2M9JLF9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_33115</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000019">
        <property type="protein sequence ID" value="PJN07607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN07607">
        <property type="protein sequence ID" value="PJN07607"/>
        <property type="gene ID" value="CG723_33115"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="22"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN07607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="162" mass="16804" checksum="4F6DB44595E9B787" modified="2018-04-25" version="1">MTTPPPQGQNPFAQGQQPSGPPQGGPYAPVAGQPGVPQQPYPPHAPGTPIPPGRPAGGGKKKALRIVALIVVAIALYGVKWYLGQSDAETTAVGSCLHNNGTTSAPDLKDVDCSSSDSEYKVIEKFDGTSDVDKCNSVQGTEVSYYQSGGSHDVVLCLKETK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JLR8</accession>
    <name>A0A2M9JLR8_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">AAA ATPase forming ring-shaped complexes</fullName>
            <shortName evidence="2">ARC</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2 6" type="primary">arc</name>
        <name evidence="6" type="ORF">CG723_32610</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CB01635</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2">Homohexamer. Assembles into a hexameric ring structure.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 3">Belongs to the AAA ATPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000018">
        <property type="protein sequence ID" value="PJN07808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN07808">
        <property type="protein sequence ID" value="PJN07808"/>
        <property type="gene ID" value="CG723_32610"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000502">
        <property type="term" value="C:proteasome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019941">
        <property type="term" value="P:modification-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010498">
        <property type="term" value="P:proteasomal protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02112">
        <property type="entry name" value="ARC_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032501">
        <property type="entry name" value="Prot_ATP_ID_OB_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041626">
        <property type="entry name" value="Prot_ATP_ID_OB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022482">
        <property type="entry name" value="Proteasome_ATPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16450">
        <property type="entry name" value="Prot_ATP_ID_OB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17758">
        <property type="entry name" value="Prot_ATP_OB_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03689">
        <property type="entry name" value="pup_AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0647">Proteasome</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA" evidence="5">
        <location>
            <begin position="265"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="53"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="276"/>
            <end position="281"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PJN07808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="588" mass="65024" checksum="C05DD885D6500550" modified="2018-04-25" version="1">MAAHDDDMNRGIRPGRGSDDPAGQIAYLEQEIAVLRRKLADSPRHTRILEERIVELQTNLAGVSAQNERLANTLREARDQIVALKEEVDRLAQPPAGFGVFLVANEDGTADIFTGGRKLRVNVSPSVELEELRRGQEVMLNEALNVVEAMEYESVGDIVTLKEILEDGERALVVGHTDEERVVRLAEPLLDINIRPGDALLLEPRSGYVYEVVPKSEVEELVLEEVPDIGYEQIGGLGNQIELIRDAVELPYLYPDLFKEHELRPPKGVLLYGPPGCGKTLIAKAVANSLAKKVAEVTGQATGKSFFLNIKGPELLNKYVGETERQIRLVFQRAREKASEGTPVIVFFDEMESLFRTRGSGVSSDVENTIVPQLLAEIDGVEGLENVVVIGASNREDMIDPAILRPGRLDVKIKIERPDAEAAKDIFAKYLTARLPLHSDDLGEHGGDRASTVHGMIQTAVEQMYAESEENRFLEVTYANGDKEVLYFKDFNSGAMIENIVGRAKKAAIKAFLEHNQKGLRVSHLLQACVDEFKENEDLPNTTNPDDWARISGKKGERIVYIRTLVTGKQGADTGRSIDTVANTGQYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JLU4</accession>
    <name>A0A2M9JLU4_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Phenylalanine--tRNA ligase beta subunit</fullName>
            <ecNumber evidence="14">6.1.1.20</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Phenylalanyl-tRNA synthetase beta subunit</fullName>
            <shortName evidence="14">PheRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="primary">pheT</name>
        <name evidence="19" type="ORF">CG723_32320</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">CB01635</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 14">
            <text>ATP + L-phenylalanine + tRNA(Phe) = AMP + diphosphate + H(+) + L-phenylalanyl-tRNA(Phe)</text>
            <dbReference type="Rhea" id="RHEA:19413"/>
            <dbReference type="Rhea" id="RHEA-COMP:9668"/>
            <dbReference type="Rhea" id="RHEA-COMP:9699"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58095"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78531"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.20"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="14">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="14">Binds 2 magnesium ions per tetramer.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4 14">Tetramer of two alpha and two beta subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 14">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.20" evidence="14"/>
    <dbReference type="EMBL" id="NNBL01000018">
        <property type="protein sequence ID" value="PJN07757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN07757">
        <property type="protein sequence ID" value="PJN07757"/>
        <property type="gene ID" value="CG723_32320"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004826">
        <property type="term" value="F:phenylalanine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006432">
        <property type="term" value="P:phenylalanyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00769">
        <property type="entry name" value="PheRS_beta_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02796">
        <property type="entry name" value="tRNA_bind_bactPheRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.380">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00283">
        <property type="entry name" value="Phe_tRNA_synth_beta1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005146">
        <property type="entry name" value="B3/B4_tRNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005121">
        <property type="entry name" value="Fdx_antiC-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036690">
        <property type="entry name" value="Fdx_antiC-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045060">
        <property type="entry name" value="Phe-tRNA-ligase_IIc_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004532">
        <property type="entry name" value="Phe-tRNA-ligase_IIc_bsu_bact"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020825">
        <property type="entry name" value="Phe-tRNA_synthase-like_B3/B4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041616">
        <property type="entry name" value="PheRS_beta_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002547">
        <property type="entry name" value="tRNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033714">
        <property type="entry name" value="tRNA_bind_bactPheRS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005147">
        <property type="entry name" value="tRNA_synthase_B5-dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10947">
        <property type="entry name" value="PTHR10947"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03483">
        <property type="entry name" value="B3_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03484">
        <property type="entry name" value="B5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03147">
        <property type="entry name" value="FDX-ACB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01588">
        <property type="entry name" value="tRNA_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17759">
        <property type="entry name" value="tRNA_synthFbeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00873">
        <property type="entry name" value="B3_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00874">
        <property type="entry name" value="B5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00896">
        <property type="entry name" value="FDX-ACB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="SSF46955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54991">
        <property type="entry name" value="SSF54991"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00472">
        <property type="entry name" value="pheT_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51483">
        <property type="entry name" value="B5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51447">
        <property type="entry name" value="FDX_ACB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50886">
        <property type="entry name" value="TRBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13 14" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="9 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="14" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 14 19" id="KW-0436">Ligase</keyword>
    <keyword evidence="10 14" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12 14" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11 15" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5 15" id="KW-0820">tRNA-binding</keyword>
    <feature type="domain" description="TRNA-binding" evidence="16">
        <location>
            <begin position="42"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="domain" description="B5" evidence="18">
        <location>
            <begin position="413"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="domain" description="FDX-ACB" evidence="17">
        <location>
            <begin position="741"/>
            <end position="834"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="465"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="471"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="474"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="475"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="PJN07757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="836" mass="89244" checksum="C67ABEAEF6517107" modified="2018-04-25" version="1">MRIPLSWLREYVDLPATETGRDLQEKLVATGLEVETVEQLGAGLKGPLVVGQVLTIEELEGFKKPIRFCTVDVGQANGTGEPQEIVCGARNFAVGDKVVVVLPGAVLPGDFAIAARKTYGRTSHGMICSGDELGMGDDGSGGIIVLPPEHEVGTDAIELLQLVDEVLDIAVTANRGDCLSLRGVAREAAIAYGLPLRDPALLDVPAPNANGYPVQISEPAGCDRFTARTVTGLNPEARSPIWLQRRLQKAGMRPISLAVDITNYVMLELGQPLHAYDRSLVQGTIGVRRAEQGEKFTTLDGAKRVLDAEDLVITDDRGPIGLAGVMGGANTEIADHGADAGTTDVVIEAAHFDPVSIARTARRHKLSSEASKRFERGVDTEAASAAAQRTVDLLVLLAGGTADPGVTEVIAPSGPHTITLPADHPDKVAGVTYGRETVVRRLQQVGCDVYGQDNLTVTVPSWRPDLREPNDLAEEVIRLEGYENLPSTLPRPPAGRGLTERQRLHRRAGRALAGAGYVEALNYPFISDETLGKLGIEQDDPRRTTVKLVNPLSDEEPALRTTLLPGLLEALRRNDGRGSHDLALFETGLVFRPTGDEPQAVRLPIDRRPTDEEIAGLDAALPRQPRHAAVVLTGAREQAGWWGNGRPAEWADAVEAARTIAREAGVELIVRGDQHAPWHPGRCAALFAVVDGAETLVGHAGELHPRVIKALHLPERSCAMEVDLDRIERAGTGALQAPRISTFPVATQDVALVVDASVPAADVEQALREGAGELLESLRLFDVFTGEQLGEGRKSLAYALRFRAGDRTLTVDEASAARDAAVALAAERTGAVLRGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JLY1</accession>
    <name>A0A2M9JLY1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Rieske (2Fe-2S) protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CG723_31230</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000017">
        <property type="protein sequence ID" value="PJN07872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN07872">
        <property type="protein sequence ID" value="PJN07872"/>
        <property type="gene ID" value="CG723_31230"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.102.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017941">
        <property type="entry name" value="Rieske_2Fe-2S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036922">
        <property type="entry name" value="Rieske_2Fe-2S_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044043">
        <property type="entry name" value="VanA_C_cat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00355">
        <property type="entry name" value="Rieske"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19112">
        <property type="entry name" value="VanA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50022">
        <property type="entry name" value="SSF50022"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51296">
        <property type="entry name" value="RIESKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rieske" evidence="5">
        <location>
            <begin position="9"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PJN07872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="355" mass="39620" checksum="6BC71434AAF4128E" modified="2018-04-25" version="1">MPSWPVNQWYVAAYSEEIGDGLLGRTICGEPLVFYRTGEGEVVALADRCVHRRYPLSLSHLKDDQIVCGYHGFTYDKTGACVAAPAQKRIPRTARVPAWTVREQDSLVWVWIGDQELADEALIPRAPWLDSPDYTVVRGMEPLKARYSLLVDNLMDLSHETYLHGGYIGTPEVAETPITTEVDEDANVVYVSRHMDDAECPPFYSKSTGIDGRITRWQDVEYHAPCLYLLHSRIAPAGVLPPEEGPDDKAFHVEVTYGITPSTEHETLDFWMVSRDFALDDEEVTAFLATNNHTVVMQDVVALDLLEKVVEGEKENYQELSINIDTGALAARRILTKLVAQGEERTAAAKAVTAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JM02</accession>
    <name>A0A2M9JM02_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_31365</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000017">
        <property type="protein sequence ID" value="PJN07892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN07892">
        <property type="protein sequence ID" value="PJN07892"/>
        <property type="gene ID" value="CG723_31365"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036520">
        <property type="entry name" value="UPF0759_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117396">
        <property type="entry name" value="SSF117396"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="128"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN07892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="151" mass="15706" checksum="500317B971CF5F0F" modified="2018-04-25" version="1">MIPGIFSRGTSRVHRSCRPTASGHAPEAGAVAPSTISPSAASGAPARARDVARFEEFHRPKRRTRSTRLHGRIADAWPDQDDVYVYFNNDLGGAAVVDATRFALAVATLGPHGEPDAGAGTPGLSLRMRGPTHQRGADASAARDAGSLLGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JM54</accession>
    <name>A0A2M9JM54_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">TetR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_31130</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000017">
        <property type="protein sequence ID" value="PJN07857.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN07857">
        <property type="protein sequence ID" value="PJN07857"/>
        <property type="gene ID" value="CG723_31130"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="12"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="34"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN07857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="189" mass="19572" checksum="21DA10DC65AB7CEA" modified="2018-04-25" version="1">MTQARAPRADAVRNRKKILTAAGEQITAHGPDVGMDEIAAAAGVAVGTLYRHFPTKTDLVAAVVAEFVARVADDAEAALARVSTGIRALDELTAFLGRVIEASVTDRAVKAAAQALGAEPGDRAAEDRAGAAVAALIHAGQADGDIHPDVTVNDIYLLFSTAPTDQPSVDRWLTLVVPGLTTQARPTDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-06-02" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JMZ1</accession>
    <name>A0A2M9JMZ1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_30035</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000015">
        <property type="protein sequence ID" value="PJN08242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08242">
        <property type="protein sequence ID" value="PJN08242"/>
        <property type="gene ID" value="CG723_30035"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN08242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="107" mass="12177" checksum="5DF7DB79832E1769" modified="2018-04-25" version="1">MNARGTIDRPLTHDPQKQAPMKPSTSEPTGSATPDFTTTDANDSRQNRTREMQLIPEALARAHMHERLRSTEAERRALRLATARRMQRRAERASLRARRALAMAVMQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JMZ4</accession>
    <name>A0A2M9JMZ4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CG723_30065</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000015">
        <property type="protein sequence ID" value="PJN08248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08248">
        <property type="protein sequence ID" value="PJN08248"/>
        <property type="gene ID" value="CG723_30065"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.160.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002838">
        <property type="entry name" value="AIM24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036983">
        <property type="entry name" value="AIM24_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016031">
        <property type="entry name" value="Trp_RNA-bd_attenuator-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01987">
        <property type="entry name" value="AIM24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51219">
        <property type="entry name" value="SSF51219"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PJN08248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="226" mass="24045" checksum="6A638068CCCCB81E" modified="2018-04-25" version="1">MNQPLAGYAPTPVAARMENHGANMLKVAMQTGNDLLARVGSMVAYEGFVQYEPNPPAVRQIARDWMTGEGAPLMKATGDGILYLADYGAEIVVINLGGDSISVNGTNLLAFDAHLQWGVERVKGLAKFAGQGLWNIKISGQGYVALTSRGTPIVVDCGRGEDETYVDPDALIAWSPNLKVKGKRSFKAGSLIGRGSGEAYQMGFSGEGIVVVQPSEDSTDRLRVRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JMZ9</accession>
    <name>A0A2M9JMZ9_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Transcriptional regulator WhiB</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">whiB</name>
        <name evidence="15" type="ORF">CG723_30030</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">CB01635</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Acts as a transcriptional regulator. Probably redox-responsive. The apo- but not holo-form probably binds DNA.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="12">Binds 1 [4Fe-4S] cluster per subunit. Following nitrosylation of the [4Fe-4S] cluster binds 1 [4Fe-8(NO)] cluster per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 12">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="12">The Fe-S cluster can be nitrosylated by nitric oxide (NO).</text>
    </comment>
    <comment type="PTM">
        <text evidence="12">Upon Fe-S cluster removal intramolecular disulfide bonds are formed.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the WhiB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000015">
        <property type="protein sequence ID" value="PJN08241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08241">
        <property type="protein sequence ID" value="PJN08241"/>
        <property type="gene ID" value="CG723_30030"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043231">
        <property type="term" value="C:intracellular membrane-bounded organelle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035731">
        <property type="term" value="F:dinitrosyl-iron complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01479">
        <property type="entry name" value="WhiB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034768">
        <property type="entry name" value="4FE4S_WBL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000637">
        <property type="entry name" value="HMGI/Y_DNA-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003482">
        <property type="entry name" value="Whib"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38839">
        <property type="entry name" value="PTHR38839"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02467">
        <property type="entry name" value="Whib"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51674">
        <property type="entry name" value="4FE4S_WBL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00354">
        <property type="entry name" value="HMGI_Y"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 12" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="12" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10 12" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9 12" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6 12" id="KW-0408">Iron</keyword>
    <keyword evidence="7 12" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="5 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11 12" id="KW-0804">Transcription</keyword>
    <keyword evidence="8 12" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="4Fe-4S Wbl-type" evidence="14">
        <location>
            <begin position="48"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="49"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="72"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="75"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="81"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51674"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="PJN08241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="122" mass="13100" checksum="ED4DE29D77218AD6" modified="2018-04-25" version="1">MQLEAHAPSVPPSDTLPPPGLTEDPTLNPLTALTALDDAIESLGVPVPCRAYDPEVFFAESPADVEYAKSLCRTCPLVEACLAGAKERREPWGVWGGELFVQGVVVARKRPRGRPRKNPVAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JN65</accession>
    <name>A0A2M9JN65_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Arsenite S-adenosylmethyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_28280</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000014">
        <property type="protein sequence ID" value="PJN08299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08299">
        <property type="protein sequence ID" value="PJN08299"/>
        <property type="gene ID" value="CG723_28280"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026669">
        <property type="entry name" value="Arsenite_MeTrfase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025714">
        <property type="entry name" value="Methyltranfer_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43675">
        <property type="entry name" value="PTHR43675"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13847">
        <property type="entry name" value="Methyltransf_31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltranfer_dom" evidence="1">
        <location>
            <begin position="79"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN08299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="260" mass="27050" checksum="B26EFAA86901DB8F" modified="2018-04-25" version="1">MSERHPDLHVRETVRERYAAAATQVTEGGTACCGPQAIEIDDHFGATLYAADERDALPAEAVAASLGCGNPTAVADLHEGEVGLDLGSGGGIDVLLSARRVGPTGKAYGLDMTEEMLALALANQRKAGAPNVEFLKGTIEAIPLPANTVDVVISNCVINLSTDKQAVFAEMFRVLVTSGRIGISDVVADDELTSPQRVERGDYVGCIAGALSFSEYREGLESAGFTDIDITPTHAVADGMHAATVRAAKPTAVRCPNGTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JNL4</accession>
    <name>A0A2M9JNL4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Pyruvate dehydrogenase (Acetyl-transferring) E1 component subunit alpha</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">pdhA</name>
        <name evidence="5" type="ORF">CG723_29185</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CB01635</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000014">
        <property type="protein sequence ID" value="PJN08450.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08450">
        <property type="protein sequence ID" value="PJN08450"/>
        <property type="gene ID" value="CG723_29185"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016624">
        <property type="term" value="F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001017">
        <property type="entry name" value="DH_E1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017596">
        <property type="entry name" value="PdhA/BkdA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11516:SF41">
        <property type="entry name" value="PTHR11516:SF41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00676">
        <property type="entry name" value="E1_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03181">
        <property type="entry name" value="PDH_E1_alph_x"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="E1_dh" evidence="4">
        <location>
            <begin position="69"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PJN08450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="392" mass="43043" checksum="3A4756058E3D391B" modified="2018-04-25" version="1">MTVDSTAAARTPRKRTAAKKSAKKSPGVGAPDLVQLLSPEGRRVEDPAHAEYAAFVEDITADELRGLYRDMVLTRRFDAEATSLQRQGELGLWASLLGQEAAQIGSGRATRDDDYVFPTYREHGVAWCRGVDPTNLLGMFRGVNNGGWDPNSNNFHLYTIVIGSQTLHATGYAMGIAKDGADSAVIAYFGDGASSQGDVAESFTFSAVYNAPVVFFCQNNQWAISEPTEKQTRVPLYQRAQGYGFPGVRVDGNDVLACLAVTKWALERARRGEGPTLVEAFTYRMGAHTTSDDPSKYRADEEREAWEAKDPILRLRTYLESETDTDEGFFAELEAESEALGLRVREVVRAMPDPDRMAIFENAYADGHSLVDEERAQFAAYQASFSDAEGGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JP26</accession>
    <name>A0A2M9JP26_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Citrate synthase (unknown stereospecificity)</fullName>
            <ecNumber evidence="3">2.3.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CG723_26395</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CB01635</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Carbohydrate metabolism; tricarboxylic acid cycle.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the citrate synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.3.16" evidence="3"/>
    <dbReference type="EMBL" id="NNBL01000012">
        <property type="protein sequence ID" value="PJN08633.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08633">
        <property type="protein sequence ID" value="PJN08633"/>
        <property type="gene ID" value="CG723_26395"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00223"/>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036440">
        <property type="term" value="F:citrate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016142">
        <property type="entry name" value="Citrate_synth-like_lrg_a-sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016143">
        <property type="entry name" value="Citrate_synth-like_sm_a-sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002020">
        <property type="entry name" value="Citrate_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019810">
        <property type="entry name" value="Citrate_synthase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036969">
        <property type="entry name" value="Citrate_synthase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11739">
        <property type="entry name" value="PTHR11739"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00285">
        <property type="entry name" value="Citrate_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00143">
        <property type="entry name" value="CITRTSNTHASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48256">
        <property type="entry name" value="SSF48256"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00480">
        <property type="entry name" value="CITRATE_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5 6" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010566"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PJN08633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="376" mass="40545" checksum="FA13ACCF9DA5B0A3" modified="2018-04-25" version="1">MSDPGLDPGPVPGFVPGLEGVVAFETEIAEPDKEGGALRYRGVDIEDLVGHVSFGNVWGLLVDGAFNPGLPPAEPFPIPVHSGDIRVDVQSALAMLAPVWGLKPLLDIDEAQAREDLARAAVMALSYVAQSARGQGRPMVPQREIDKADTVVERFMKRWRGEPDPKHVAAVDAYWTSAAEHGMNASTFTARVIASTGADVAAALSGAVGAMSGPLHGGAPSRVLGMIEEIERTGDADAYVRRALDKGERLMGFGHRVYRAEDPRARVLRRTARELGAPRFEVAEALEKAALAELHARRPDRVLATNVEFWAAIMLDFAEVPAHMFTSMFTCARTAGWSAHILEQKRTGRLVRPSARYIGPGTRDPRDIEGYGDISG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JP61</accession>
    <name>A0A2M9JP61_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">AraC family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_26535</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000012">
        <property type="protein sequence ID" value="PJN08658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08658">
        <property type="protein sequence ID" value="PJN08658"/>
        <property type="gene ID" value="CG723_26535"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002818">
        <property type="entry name" value="DJ-1/PfpI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01965">
        <property type="entry name" value="DJ-1_PfpI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="1">
        <location>
            <begin position="229"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN08658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="340" mass="37035" checksum="DA18BAFCD70FCC0B" modified="2018-04-25" version="1">MPETPAPRTQRPHRVVVLALDGVLPFELGITQRIFSRAKDSAGRPLYEVVTCSVREPGPVETDADFAVLIRNGPEALATADTVVVPASYELGPVVNEGVLTDELAAAFAQVRTGTRMVSICTGSYVLAAAGYLDGRPATTHWTSAEHFQRLFPEIKVDADVLYIDDGDVLTSAGVAAGIDLCLHLVRRDHGTAVANEVARHTVVPPHRDGGQAQYIHRPVPEPQLATTTKARAWALARLHEPLQLRDLAAQEAMSVRTFTRRFREEAGVSPGQWLTQQRVERARHLLESSDLSMDQVARESGFGTAQSMRQHLQAALGVTPTAYRRTFHATAVQGAMQNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JPJ7</accession>
    <name>A0A2M9JPJ7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Amino acid permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CG723_26590</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CB01635</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000012">
        <property type="protein sequence ID" value="PJN08802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08802">
        <property type="protein sequence ID" value="PJN08802"/>
        <property type="gene ID" value="CG723_26590"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006865">
        <property type="term" value="P:amino acid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004840">
        <property type="entry name" value="Amoino_acid_permease_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00218">
        <property type="entry name" value="AMINO_ACID_PERMEASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="47"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="92"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="136"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="167"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="205"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="245"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="287"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="347"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="370"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="411"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="441"/>
            <end position="459"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PJN08802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="483" mass="52017" checksum="4E677D2102028BC7" modified="2018-04-25" version="1">MGYPRKLTRRFKAFDNFAISFTIINIISGIFSSFGFGMNAGGPRILVFGWIAVAAMVLFVGASMAEIASAYPTSGALYFSAGKLAKRHKGAWSWYTGWLNFVGQVGGTAATGYAAATFIQAFVVMQWPSYHATAQQTVLITAVILLLQALANTYTVQLVALVNRISVWWLLVGMVVIVVALIAVPDHHQSASVVTQFTNNTGFSNGIYAALLGLLVTSWTFTGFDGSFHMSEETVQATVNAPKGIMRAIGYSAVTGLILMLALVFAIGDYAAEASASAPPVQILIDALGMTTAKLLLLIVIGSMLFCGLANMTSNTRQIFAFSRDGAMPGSRWWHSVSSRTRTPVKAVWLAAACSLVLVVPGWWSHTAFTAIVSVNVVGLYLAYAVPIYLRLRHDDFQQGPWNLGRWGKPVAAIAVVWIVASSVLFMLPQASPINATSFNYAPIALVAVLVIATVWWFATARRRFQGPVSYGSPDEVAAMDLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JPR7</accession>
    <name>A0A2M9JPR7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">GntR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CG723_25380</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000011">
        <property type="protein sequence ID" value="PJN08835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08835">
        <property type="protein sequence ID" value="PJN08835"/>
        <property type="gene ID" value="CG723_25380"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.530">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011711">
        <property type="entry name" value="GntR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008920">
        <property type="entry name" value="TF_FadR/GntR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07729">
        <property type="entry name" value="FCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
        <property type="entry name" value="GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00035">
        <property type="entry name" value="HTHGNTR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00895">
        <property type="entry name" value="FCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00345">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48008">
        <property type="entry name" value="SSF48008"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50949">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH gntR-type" evidence="4">
        <location>
            <begin position="2"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PJN08835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="208" mass="22670" checksum="8EC671AEA4802ACD" modified="2018-04-25" version="1">MTSGRDKAYAFLKENVLADPDRQGEFLSEQELADRIGVSRTPIREALLLLAAEDLVRLVPKRGAQVVPLSGREITELMELRGIVERYSAERVIAEGKAPVSELTALLGRQRTLSGAEHAKEFIAVDHLFHATIVAAAGNALLDRHYDGLRSRQIRAGVVALFNQHGRQESVLHEHEAILDAIAAGDRQAACTAIDSHLESTLKVLLAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JQ77</accession>
    <name>A0A2M9JQ77_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 17">Homoserine dehydrogenase</fullName>
            <ecNumber evidence="6 17">1.1.1.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">CG723_25740</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">CB01635</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>L-homoserine + NAD(+) = H(+) + L-aspartate 4-semialdehyde + NADH</text>
            <dbReference type="Rhea" id="RHEA:15757"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57476"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:537519"/>
            <dbReference type="EC" id="1.1.1.3"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 17">
            <text>L-homoserine + NADP(+) = H(+) + L-aspartate 4-semialdehyde + NADPH</text>
            <dbReference type="Rhea" id="RHEA:15761"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57476"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:537519"/>
            <dbReference type="EC" id="1.1.1.3"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4 17">Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; L-homoserine from L-aspartate: step 3/3.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 17">Amino-acid biosynthesis; L-threonine biosynthesis; L-threonine from L-aspartate: step 3/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5 18">Belongs to the homoserine dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.3" evidence="6 17"/>
    <dbReference type="EMBL" id="NNBL01000011">
        <property type="protein sequence ID" value="PJN09020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN09020">
        <property type="protein sequence ID" value="PJN09020"/>
        <property type="gene ID" value="CG723_25740"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00050">
        <property type="reaction ID" value="UER00063"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00051">
        <property type="reaction ID" value="UER00465"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004412">
        <property type="term" value="F:homoserine dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009097">
        <property type="term" value="P:isoleucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009086">
        <property type="term" value="P:methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009088">
        <property type="term" value="P:threonine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002912">
        <property type="entry name" value="ACT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005106">
        <property type="entry name" value="Asp/hSer_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016204">
        <property type="entry name" value="HDH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001342">
        <property type="entry name" value="HDH_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019811">
        <property type="entry name" value="HDH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01842">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00742">
        <property type="entry name" value="Homoserine_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03447">
        <property type="entry name" value="NAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000098">
        <property type="entry name" value="Homoser_dehydrog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="SSF55021"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51671">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01042">
        <property type="entry name" value="HOMOSER_DHGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 17" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="14 17" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="9 17" id="KW-0412">Isoleucine biosynthesis</keyword>
    <keyword evidence="13 17" id="KW-0486">Methionine biosynthesis</keyword>
    <keyword evidence="11 16 17" id="KW-0521">NADP</keyword>
    <keyword evidence="12 17" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 17" id="KW-0791">Threonine biosynthesis</keyword>
    <feature type="domain" description="ACT" evidence="19">
        <location>
            <begin position="352"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="15">
        <location>
            <position position="206"/>
        </location>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <begin position="11"/>
            <end position="18"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="106"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="191"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00006753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00013213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00013376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR000098-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR000098-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU000579"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="RuleBase" id="RU004171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="PJN09020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="429" mass="44307" checksum="11106C4E884B478D" modified="2018-04-25" version="1">MRTRPLKVALLGCGVVGSEVARIMTTHADDLAARIGAPVELAGVAVRRPSKVREGIDPSLVTTDATALVKRGDIDVVVEVIGGIEPARGLIMTAFEHGASVVSANKALIAQDGAALHAAAEEHGKDLYYEAAVAGAIPLIRPLRESLAGDKINRVMGIVNGTTNFILDKMDSTGAGYQEALDEATALGYAEADPTADVEGFDAAAKAAILAGISFHTRVRLDDVYREGMTEVTAADFASAKEMGCTIKLLAICERAAHGGSVTARVHPAMIPLDHPLASVRGAYNAVFVEAEAAGQLMFYGPGAGGAPTASAVLGDLVAVCRNKLGEATGPGDSAYTQLPVSPMGEVVTRYHISLDVADKPGVLAQVATVFAEHGVSIDTVRQSGKDGEASLVVVTHRAADAALTGTVDALRKLDTVRGVASIMRVEGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JQC9</accession>
    <name>A0A2M9JQC9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcriptional repressor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_24455</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Fur family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000010">
        <property type="protein sequence ID" value="PJN09080.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN09080">
        <property type="protein sequence ID" value="PJN09080"/>
        <property type="gene ID" value="CG723_24455"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07153">
        <property type="entry name" value="Fur_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002481">
        <property type="entry name" value="FUR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043135">
        <property type="entry name" value="Fur_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33202">
        <property type="entry name" value="PTHR33202"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01475">
        <property type="entry name" value="FUR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN09080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="155" mass="17384" checksum="ED8FDBE6137906E8" modified="2018-04-25" version="1">MVSTDWKSDLRQRGYRLTPQRQLVLEAVDTLEHATPDDILCEVRKTASGINISTVYRTLELLEELDLVSHAHLGHGAPTYHLADRHHHMHLVCRDCTNVIEADVEVAAEFTAKLRDTFGFDTDLKHFAIFGRCADCSKRDGTEIKGGDESAAPQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JQE4</accession>
    <name>A0A2M9JQE4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Serine protease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CG723_24355</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000010">
        <property type="protein sequence ID" value="PJN09065.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN09065">
        <property type="protein sequence ID" value="PJN09065"/>
        <property type="gene ID" value="CG723_24355"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00190">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013517">
        <property type="entry name" value="FG-GAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028994">
        <property type="entry name" value="Integrin_alpha_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001314">
        <property type="entry name" value="Peptidase_S1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018114">
        <property type="entry name" value="TRYPSIN_HIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033116">
        <property type="entry name" value="TRYPSIN_SER"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13517">
        <property type="entry name" value="FG-GAP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00722">
        <property type="entry name" value="CHYMOTRYPSIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="SSF50494"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69318">
        <property type="entry name" value="SSF69318"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00134">
        <property type="entry name" value="TRYPSIN_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00135">
        <property type="entry name" value="TRYPSIN_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 7" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0720">Serine protease</keyword>
    <keyword evidence="1 5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014611693" evidence="5">
        <location>
            <begin position="39"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S1" evidence="6">
        <location>
            <begin position="89"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="43"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU363034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PJN09065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="584" mass="61779" checksum="FC2DE71153958A90" modified="2018-04-25" version="1">MIPALRDRWRRPATALSTAALALALSCAGALVAHPATAADEPPVLPDASVARTANPAPSASDAELRKRVVEAAKTQATPETKPKRTPFIIGGTETAISSAPWMVQLSYYDAASGDGYFCGGTLVAPNKVLTAAHCVAGLDWVNNGAVVAGTAGLLDSAQGTVAGVWRQWNHPRYNADTIQNDIAVLTLDRPLEDQWAKVVQSNDTASYKAGTSATVYGWGLTSGAEDADLSATLRKATLPMVSDSTCNTAMQSVLGEDDFIEGSMFCAGTPATGADEGTKSPCSGDSGGPVVVGGRVVGIVSWGVSGCTAKGAYPVFTKVSSYVWAAQPRIDDTDLSFDGRADLLARTPSGGLFEQDSKGTSLTTRAYQSAGWQTASWALQADLDRDFFQDLIIRDSTDGKLYRSYYNHASDAFEWMQITSVWGGYKSYAIPGDMTGDSRPDLVAVDADGSTYLYPGKGNGEFYGKVKVVDKAWKGVKIFGHGDLTGDGKADLLVRNSSGVLYLYRGTQVEKTPFAARIQARTGWNFTSYVTNGDVTGDGIADVMARDSGGTLWLYPGTNKASADVFGARKSLGTGFNQYNLMF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JQN1</accession>
    <name>A0A2M9JQN1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Molybdopterin synthase sulfur carrier subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CG723_24970</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000010">
        <property type="protein sequence ID" value="PJN09165.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN09165">
        <property type="protein sequence ID" value="PJN09165"/>
        <property type="gene ID" value="CG723_24970"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016155">
        <property type="entry name" value="Mopterin_synth/thiamin_S_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003749">
        <property type="entry name" value="ThiS/MoaD-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02597">
        <property type="entry name" value="ThiS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54285">
        <property type="entry name" value="SSF54285"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PJN09165.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="91" mass="9539" checksum="07E8A0D013CE83AB" modified="2018-04-25" version="1">MSVNVRIPTILRTYTGGKAEVAAEGATLSEVIADLEKNHTGIAARVLDDQGKLRRFVNVYVNDDDVRFEQGLETATPAGAGVSIIPAVAGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JQZ4</accession>
    <name>A0A2M9JQZ4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_23335</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000009">
        <property type="protein sequence ID" value="PJN09288.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN09288">
        <property type="protein sequence ID" value="PJN09288"/>
        <property type="gene ID" value="CG723_23335"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002878">
        <property type="entry name" value="DUF35_OB-fold_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01796">
        <property type="entry name" value="OB_aCoA_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OB_aCoA_assoc" evidence="1">
        <location>
            <begin position="42"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN09288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="123" mass="12562" checksum="CBA6A116F6D34E1E" modified="2018-04-25" version="1">MTTDPRSPATGLQGARCSGCAVAVYPADDTCPRCGGPAESAALSGAGTLWTWTVQRYAPKSPPYQEPPGGFAPFAVGYVELAEGVRVAAVLDVDDLDTVRIGMPLTVTAGSGVPRARPAQEAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JR36</accession>
    <name>A0A2M9JR36_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Arsenical-resistance protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">arsB</name>
        <name evidence="5" type="ORF">CG723_23685</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CB01635</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 3">Belongs to the arsenical resistance-3 (ACR3) (TC 2.A.59) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000009">
        <property type="protein sequence ID" value="PJN09341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN09341">
        <property type="protein sequence ID" value="PJN09341"/>
        <property type="gene ID" value="CG723_23685"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015297">
        <property type="term" value="F:antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015103">
        <property type="term" value="F:inorganic anion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004706">
        <property type="entry name" value="Arsenical-R_Acr3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002657">
        <property type="entry name" value="BilAc:Na_symport/Acr3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038770">
        <property type="entry name" value="Na+/solute_symporter_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43057">
        <property type="entry name" value="PTHR43057"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01758">
        <property type="entry name" value="SBF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005508">
        <property type="entry name" value="Acr3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00832">
        <property type="entry name" value="acr3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="30"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="61"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="102"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="127"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="158"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="200"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="241"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="271"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="304"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="333"/>
            <end position="355"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR005508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PJN09341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="370" mass="39568" checksum="DACBBE5F49C7D875" modified="2018-04-25" version="1">MSRTDTIPQTGQGAASGAGIVAKLSTLDRYLAVWILIAMGVGLGLGRLIPGLNDALAKVEIGGVSLPIALGLLVMMYPVLAKVRYDKLDTVTGDKRLMVSSLVINWIVGPAVMFALAWIFLPDLPEYRTGLIIVGLARCIAMVIIWNDLACGDREAAAVLVALNSVFQVIAFGLLGWFYLDLLPKWLGLGDGQSLDISMWKIALNVVIFLGIPLVAGFLTRRVGEKKLGRQKYESDFLPKIGPWALYGLLFTIVILFALQGKTITSQPVDVVRIALPLLVYFAVMFFGTFLLGKGLGLAYDRTATLAFTAAGNNFELAIAVAIATFGVTSGQALSGVVGPLIEVPVLIGLVYVALAWRKKFTASVIGTPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JRD7</accession>
    <name>A0A2M9JRD7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CG723_24125</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000009">
        <property type="protein sequence ID" value="PJN09412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN09412">
        <property type="protein sequence ID" value="PJN09412"/>
        <property type="gene ID" value="CG723_24125"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PJN09412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="216" mass="23065" checksum="739BC3EA80C5B2DB" modified="2018-04-25" version="1">MSLVSTPTPPRGGFVFLDPEQGRVLRVAPFQYNPDTLTRTLQPQGIGGEAGDRLEALRLKGPPHETFKIDAEFDAADQLQLVTGAAPTASAGLFGALSALETAVCPSSAQLAHENDMASQGMLQIAPVEAPLMVLVLGRRRVLPVRITDFTITEEAYDGELNPIRAKVGMSVRVLTVDDVGFSHKAGALYIRYQQSKERFAALIGYGPGAVGYTGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JRL0</accession>
    <name>A0A2M9JRL0_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HATPase_c domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_22205</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000008">
        <property type="protein sequence ID" value="PJN09482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN09482">
        <property type="protein sequence ID" value="PJN09482"/>
        <property type="gene ID" value="CG723_22205"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13581">
        <property type="entry name" value="HATPase_c_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HATPase_c" evidence="1">
        <location>
            <begin position="33"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN09482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="142" mass="15401" checksum="A3DCFE655D61266B" modified="2018-04-25" version="1">MTSSQNDAERGEVFMTTHTAPEIQEMRCHDARAEVRAVVETACRLPSGQARRFREDALLVASELTSNAILHGGGLTRFHARIEDGSLLIQVSDHSTTTPHLVLHNPGLPGGFGWMITQRLASHVSVDIQPDGKTITAVLALP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JSA4</accession>
    <name>A0A2M9JSA4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Gamma-aminobutyraldehyde dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CG723_21445</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CB01635</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000007">
        <property type="protein sequence ID" value="PJN09765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN09765">
        <property type="protein sequence ID" value="PJN09765"/>
        <property type="gene ID" value="CG723_21445"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016620">
        <property type="term" value="F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07092">
        <property type="entry name" value="ALDH_ABALDH-YdcW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016160">
        <property type="entry name" value="Ald_DH_CS_CYS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015657">
        <property type="entry name" value="Aminobutyraldehyde_DH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="SSF53720"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00070">
        <property type="entry name" value="ALDEHYDE_DEHYDR_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00687">
        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldedh" evidence="5">
        <location>
            <begin position="19"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="251"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PJN09765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="479" mass="51445" checksum="F110CC23C28A20FC" modified="2018-04-25" version="1">MTSELRRLRNYIDGEFRDAADGRTTEVVNPANGEAYATAPLSGDADVDAAMAAAAAAFPAWRDLTPSERQKALLKIADAFEERAEELIAAEVENTGKPTGLTRSEEIPPMVDQIRFFAGAARMLEGRSAGEYMEGLTSIIRREPIGVCAQVAPWNYPMMMAVWKFAPALAAGNTVVLKPSDTTPASTVLIAEIIGSIVPKGVFNVICGDRETGRAMVEHKTPAMASITGSVRAGISVAESAAKDVKRVHLELGGKAPVVVFEDTDIAKAVEDISVAGFFNAGQDCTAATRVLVHESIHDEFVQALAKAAADTKTGQPDDEDVLYGPLNNPNQLAQVTGFIERLPAHAKVEAGGHRVGDKGYFYAPTVVSGVKQDDEIIQNEVFGPVITVQSFADEAQAVEWANGVEYALASSVWTKDHARAMRMSKILDFGCVWINTHIPLVAEMPHGGFKKSGYGKDLSAYGFDDYTRIKHVMTSIEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JSC0</accession>
    <name>A0A2M9JSC0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycerophosphodiester phosphodiesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_21465</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000007">
        <property type="protein sequence ID" value="PJN09769.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN09769">
        <property type="protein sequence ID" value="PJN09769"/>
        <property type="gene ID" value="CG723_21465"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008081">
        <property type="term" value="F:phosphoric diester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030395">
        <property type="entry name" value="GP_PDE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017946">
        <property type="entry name" value="PLC-like_Pdiesterase_TIM-brl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03009">
        <property type="entry name" value="GDPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51695">
        <property type="entry name" value="SSF51695"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51704">
        <property type="entry name" value="GP_PDE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GP-PDE" evidence="1">
        <location>
            <begin position="4"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN09769.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="226" mass="24778" checksum="C1053ABD6B75600B" modified="2018-04-25" version="1">MRTVTAVAHRGDPYRVRENTLASLRSALEQGADAVEIDVRLTRDGVPVLLHDSTLKRLWDHDRPLSALSYDEVRGLTAGGVPTLEQAMEVLAERRVMVDLPGADARVVRTVVGVIRDCGADERAYYCAGAETMLAVRRADPAAEIALTWTTLAPPRPGVLEAVRPAWLNYRFPLVSRELAAHVHRQGLLVSAWTPDTKSAMRRLLGLGIDSITTNRIDVLCGLRGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JSX9</accession>
    <name>A0A2M9JSX9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_19865</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000006">
        <property type="protein sequence ID" value="PJN09985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN09985">
        <property type="protein sequence ID" value="PJN09985"/>
        <property type="gene ID" value="CG723_19865"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="69"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="98"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN09985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="117" mass="12423" checksum="38E6AF69133DB78E" modified="2018-04-25" version="1">MDVLIHLFVGLHIIGIASLLGGFLTQMKAMGKGTARFVPAMLHGALTMLVTGVVLVGLNQADDNAVNNIKIGVKLALLIVILGLVYVKRDDEKVDKGLFGLVGLLTTANIFIAVLWT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JU03</accession>
    <name>A0A2M9JU03_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">MerR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CG723_18585</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000005">
        <property type="protein sequence ID" value="PJN10376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN10376">
        <property type="protein sequence ID" value="PJN10376"/>
        <property type="gene ID" value="CG723_18585"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015689">
        <property type="term" value="P:molybdate ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041657">
        <property type="entry name" value="HTH_17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008995">
        <property type="entry name" value="Mo/tungstate-bd_C_term_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004606">
        <property type="entry name" value="Mop_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010093">
        <property type="entry name" value="SinI_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005116">
        <property type="entry name" value="Transp-assoc_OB_typ1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12728">
        <property type="entry name" value="HTH_17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03459">
        <property type="entry name" value="TOBE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="SSF46955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50331">
        <property type="entry name" value="SSF50331"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01764">
        <property type="entry name" value="excise"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00638">
        <property type="entry name" value="Mop"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51866">
        <property type="entry name" value="MOP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0500">Molybdenum</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mop" evidence="3">
        <location>
            <begin position="64"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PJN10376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="130" mass="13760" checksum="C027E6B919DC6612" modified="2018-04-25" version="1">MQSYTIGQAARLLGVSPDTARRWADAGRVATHRDAGGRRLIDGRDLAALSVEVARTGGEDDISYTSARNAFPGIVTAVKLGDVAAQVEIQAGPHRLVSLLTREAVEELGLEVGAEATARVKSTNVHIDRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JU22</accession>
    <name>A0A2M9JU22_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 5">Glutaminase</fullName>
            <ecNumber evidence="3 5">3.5.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5 8" type="primary">glsA</name>
        <name evidence="8" type="ORF">CG723_18505</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CB01635</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 5">
            <text>H2O + L-glutamine = L-glutamate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:15889"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="EC" id="3.5.1.2"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the glutaminase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.2" evidence="3 5"/>
    <dbReference type="EMBL" id="NNBL01000005">
        <property type="protein sequence ID" value="PJN10363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN10363">
        <property type="protein sequence ID" value="PJN10363"/>
        <property type="gene ID" value="CG723_18505"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004359">
        <property type="term" value="F:glutaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.750.24">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00313">
        <property type="entry name" value="Glutaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015868">
        <property type="entry name" value="Glutaminase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002645">
        <property type="entry name" value="STAS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036513">
        <property type="entry name" value="STAS_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12544">
        <property type="entry name" value="PTHR12544"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04960">
        <property type="entry name" value="Glutaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52091">
        <property type="entry name" value="SSF52091"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03814">
        <property type="entry name" value="Gln_ase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50801">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0007">Acetylation</keyword>
    <keyword evidence="4 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="STAS" evidence="7">
        <location>
            <begin position="358"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="319"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="336"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="76"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="126"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="170"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="177"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="201"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="253"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="271"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PJN10363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="600" mass="63615" checksum="0FC2AA95FEBF1A81" modified="2018-04-25" version="1">MVFDCGVRHNKPLDDPLAALLDRVRIRLRDLTDGEPASYIPELSRADPDLFGLSLCALDGQVYSCGDSEVPFTVQSVSKPFVFALALADQGLEDVLARVGAEPSGEGFSSIRLEPGTGRPPNPMVNAGAIVTSSLVAGANPDERIGRILAGLGAFAGRDLTVDEAVFASERSTGDRNRALAYLMHNAGSLTGDVEEQLAVYFRQCSVLVTCDDLAVMHATLAGGGTNPLTGERVVASRHAQHVLAVMATCGMYDASGQWMLRVGLPAKSGVSGGIGVALPGQFGIGVFSPPLDEKGNSVRAIAACHLLSEQFGLHLMRATGSSGRPLPPRSLDPGPLRSLRHRPRDQRAALDERPDRIRVHVLQGDLDFATAEQTLRAARDLPKAARWFVLDLARVGRIEPVAADLLRALGHDLRERGIRMVIADPSARPVTHTKDEFADLGRAIESCEDELLTGLGLDPSVPVPLTDSDLFGRAGEQAAQAVFDCFGTMSLSAGQAVEPPRAEPVVLWYVESGRLAVCAHSSRPTPAGRTWSAGPGAALTPADFHARLGERVMAEEDSVCRTLTAAGLLRLRTAVPAAAAFLERSPLDGAETVDRPEGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JU29</accession>
    <name>A0A2M9JU29_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Peptidase M13</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CG723_18715</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CB01635</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase M13 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000005">
        <property type="protein sequence ID" value="PJN10395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN10395">
        <property type="protein sequence ID" value="PJN10395"/>
        <property type="gene ID" value="CG723_18715"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd08662">
        <property type="entry name" value="M13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1380.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000718">
        <property type="entry name" value="Peptidase_M13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018497">
        <property type="entry name" value="Peptidase_M13_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042089">
        <property type="entry name" value="Peptidase_M13_dom_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008753">
        <property type="entry name" value="Peptidase_M13_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11733">
        <property type="entry name" value="PTHR11733"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01431">
        <property type="entry name" value="Peptidase_M13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05649">
        <property type="entry name" value="Peptidase_M13_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00786">
        <property type="entry name" value="NEPRILYSIN"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51885">
        <property type="entry name" value="NEPRILYSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase_M13_N" evidence="9">
        <location>
            <begin position="17"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M13" evidence="8">
        <location>
            <begin position="449"/>
            <end position="650"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF05649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PJN10395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="654" mass="72794" checksum="7548B889598F0893" modified="2018-04-25" version="1">MSILDDARPGMNPEIRPQDDLFGHVNGHWLDTEPIPEDRSSWGPFVQLADTAEEQVKAIIEELAAGAESTSADTGEARKIAALYASFMDERAVEALGLAPARPLIDEVDAIADLRGLATFLGRFERVGGSGLFGSYVDTDDRNSDRYLVNVVQGGLGLPDESYYRDDKFAEIRDKYVTYLTDLLTLAEHADPTAAARTVLAIETKLAAGHWERAETRDVQKTYNLTTLDELKALAPEFDWHGYTAGIGGTDATVAETCVRQPSYFAHLSQVLTEFPIEQWRDWVLVRVLRASAPYLSDAFVQNNFDFYGRTLNGTPELRARWKRAVALVEGAMGEAVGKEYVARHFPPASKAMMDELVANLLEAYRQSIARLDWMTDETKERAYEKLATFRPKIGYPDKFRDYSKLQVTADDLLANAQAAAAFETDRELAKIGSPVDRDEWFMLPQTVNAYYNPGTNEICFPAGILQKPFFAPDADPAENYGGIGSVIGHEIGHGFDDQGAQYDGAGNLNDWWTASDKTSFEAKSKALIEQYDGFSPRNLPGESVNGALTVGENIGDLGGLTIGHKAYVISLGDTPSPEHEATTGSQRLFLNWAYCWRTKRRKEQEQQYLTIDPHSPPEFRANIVRNLDEFHDAFNTSDSDGLWLDPADRVRIW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JU57</accession>
    <name>A0A2M9JU57_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Asp/Glu racemase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_18865</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000005">
        <property type="protein sequence ID" value="PJN10421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN10421">
        <property type="protein sequence ID" value="PJN10421"/>
        <property type="gene ID" value="CG723_18865"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026286">
        <property type="entry name" value="MaiA/AMDase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40267">
        <property type="entry name" value="PTHR40267"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17645">
        <property type="entry name" value="Amdase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01590">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GAF" evidence="1">
        <location>
            <begin position="244"/>
            <end position="383"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN10421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="384" mass="41192" checksum="3B56683FCF63EB36" modified="2018-04-25" version="1">MTSHTPPRLGMLTPSSNTALEPETYALLHGTDAATAHFARVPVTRIALDGDSDAQFDPGPMLAAARQLADAKVDVIAWNGTSGSWLGVERDRALAAAITAETGIPATTSTLALLDACAAYGVTRLGLALPYTRDVCERIVDTYAKEGITCSFAEPFGEDHNEAFARIPATDIARQIEQAAEEDTHAVAVLCTNVRGAGEAERLEGALRIPVLDSVTVTLWKALDLAGAAPRLTGHGDLLRSGSLRALIQDTLNRLLAETGADRTTFRVDLPELGLHVDLTAGEALRPGVRPIRRDASLDQRNLNTVVWLEQHRKPLIQPHFHEDPHPPKALIDVYGVQAQMLAPVETGGAMTGWISVHSLAERDWTPTDTAALDDAVTRIRTAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JV95</accession>
    <name>A0A2M9JV95_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Peptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CG723_16390</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000004">
        <property type="protein sequence ID" value="PJN10762.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN10762">
        <property type="protein sequence ID" value="PJN10762"/>
        <property type="gene ID" value="CG723_16390"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004629">
        <property type="term" value="F:phospholipase C activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023849">
        <property type="entry name" value="CHP03934_TQXA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008475">
        <property type="entry name" value="PLipase_C_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013552">
        <property type="entry name" value="Thioester_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05506">
        <property type="entry name" value="DUF756"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08341">
        <property type="entry name" value="TED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03934">
        <property type="entry name" value="TQXA_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="473"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="domain" description="TED" evidence="4">
        <location>
            <begin position="125"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="domain" description="DUF756" evidence="3">
        <location>
            <begin position="365"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="433"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="435"/>
            <end position="453"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05506"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08341"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PJN10762.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="501" mass="50625" checksum="CDD387D7136ECF31" modified="2018-04-25" version="1">MSAQASDSHIVLSAGRHPPRANVSRLKGNSVFSAVSVLSAVTPRGRGAARLAAAALVSGLVATAAISGAGAASADEVPQQQGGATATIGGLKTYGQAVIHDNGKDQPVSAGLFEMSVDNGGTLQTYCIDIHNPTQRDAKYQETPWSGTSLNGNADAGKIRWILQNSYPQVNDLADLARKAGAGSLTEKDAAAGTQVAIWRYSDGADVDAVSPAAEKLADYLQKSAQPLAEPKASLNLEPSAVSGRAGERLGPVTVRTNADGVSVTPPADAAASGVKVVDKDGKPVTSAVDGGQLFFDVPEGAADGTAALTVQASTTVPVGRAFASETRSQTQILAGSSESTVSATATANWAKKGAAPALSAQKNCDKGGVDITATNKGDEAFTFELMGLEHTIAAGASQTVTIPLQEDQAYDFTIKGPNGFEKRFKGVLDCKTESTAGGSEQPSSQPSPASVGGTGTKAGDLAETGSSNATPLIAGIAIALVVIGGGAVFLVRKKKAPTQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JVB9</accession>
    <name>A0A2M9JVB9_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1 3">Nucleoside diphosphate kinase</fullName>
            <shortName evidence="1">NDK</shortName>
            <shortName evidence="1">NDP kinase</shortName>
            <ecNumber evidence="1 3">2.7.4.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Nucleoside-2-P kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">ndk</name>
        <name evidence="5" type="ORF">CG723_16805</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CB01635</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 3">
            <text>a 2'-deoxyribonucleoside 5'-diphosphate + ATP = a 2'-deoxyribonucleoside 5'-triphosphate + ADP</text>
            <dbReference type="Rhea" id="RHEA:44640"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:73316"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.6"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a ribonucleoside 5'-diphosphate + ATP = a ribonucleoside 5'-triphosphate + ADP</text>
            <dbReference type="Rhea" id="RHEA:18113"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57930"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the NDK family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.6" evidence="1 3"/>
    <dbReference type="EMBL" id="NNBL01000004">
        <property type="protein sequence ID" value="PJN10831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN10831">
        <property type="protein sequence ID" value="PJN10831"/>
        <property type="gene ID" value="CG723_16805"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004550">
        <property type="term" value="F:nucleoside diphosphate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006241">
        <property type="term" value="P:CTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006183">
        <property type="term" value="P:GTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006165">
        <property type="term" value="P:nucleoside diphosphate phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006228">
        <property type="term" value="P:UTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.141">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00451">
        <property type="entry name" value="NDP_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034907">
        <property type="entry name" value="NDK-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036850">
        <property type="entry name" value="NDK-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001564">
        <property type="entry name" value="Nucleoside_diP_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023005">
        <property type="entry name" value="Nucleoside_diP_kinase_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00334">
        <property type="entry name" value="NDK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01243">
        <property type="entry name" value="NUCDPKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00562">
        <property type="entry name" value="NDK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54919">
        <property type="entry name" value="SSF54919"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00469">
        <property type="entry name" value="NDP_KINASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 3 5" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0460">Magnesium</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0546">Nucleotide metabolism</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="NDK" evidence="4">
        <location>
            <begin position="2"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="active site" description="Pros-phosphohistidine intermediate" evidence="1">
        <location>
            <position position="117"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="10"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="59"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="87"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="93"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="104"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="114"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU004011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU004013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PJN10831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="137" mass="15002" checksum="B6F714E5B9807538" modified="2018-04-25" version="1">MSQRTLVLLKPDAVRRGLVGEIIGRIERKAGWTISALELRNLDQDTLEQHYGEHKGKPFYEPLVAFMASGPVVALVVEGERVIEGVRQLAGPTDPIAAAPGSIRGDFGTIVRENLIHASDSEESAERELKIFFPGQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-05-25" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JVF7</accession>
    <name>A0A2M9JVF7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Fatty acid-binding protein DegV</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_16990</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000004">
        <property type="protein sequence ID" value="PJN10863.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN10863">
        <property type="protein sequence ID" value="PJN10863"/>
        <property type="gene ID" value="CG723_16990"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003797">
        <property type="entry name" value="DegV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043168">
        <property type="entry name" value="DegV_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02645">
        <property type="entry name" value="DegV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00762">
        <property type="entry name" value="DegV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51482">
        <property type="entry name" value="DEGV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN10863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="281" mass="29462" checksum="6A54E937B0AC61BF" modified="2018-04-25" version="1">MSRHVAIVTDSTAYLPQRTMERHGIIAVPLTVVLGDRALEEGAEISTRSLAEALQKRRPVTTSRPSPEIFAATYRKLAEEGATSVVSLHLSSELSGTYDAAVLAAREAPVPVRVVDTGMVAMALGFCALTAAEVADGGGTVDEAVTAAEKRAAATSAYFYVDTLDYLRRGGRIGAAQALLGSALAVKPLLQLEGGRIELLEKVRTSSKAIARLQEIVAERAGTSEVDIAVHHLAAPDRAAMFADKLRERVPGLLDLHVSEVGAVIGAHTGPGLLGAVVSPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-09-29" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JVM9</accession>
    <name>A0A2M9JVM9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_17135</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000004">
        <property type="protein sequence ID" value="PJN10961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN10961">
        <property type="protein sequence ID" value="PJN10961"/>
        <property type="gene ID" value="CG723_17135"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041413">
        <property type="entry name" value="MLTR_LBD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17765">
        <property type="entry name" value="MLTR_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="2">
        <location>
            <begin position="19"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN10961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="273" mass="29845" checksum="22F0FB9AB548C9E6" modified="2018-04-25" version="1">MNRRARVTPAQAGLPDGGARRRTPGLRREEVAVLAGVGASWYQWLEQGRDISVSPQVLDAVARVLRLSGAERRHLYVLAGLNPPPASADPAAVGHDDGLRRIIDTWMPYPAHIVDPYYNCVMYNDAAATVLNMRPGNTQNCVLDFFTDPVYRSRSVSWERNAATVVAQFRAACSEYPGDEGFQEVVAATKAASAEFAELWERRDIEAAGQIRKELTHPVAGVLHVESTALKVPARPDLTIILHTPLPEADTAAKLEWLATPEGRRGAMYPVAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JVP9</accession>
    <name>A0A2M9JVP9_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Glycine--tRNA ligase</fullName>
            <ecNumber evidence="7">6.1.1.14</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Glycyl-tRNA synthetase</fullName>
            <shortName evidence="7">GlyRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">glyQS</name>
        <name evidence="9" type="ORF">CG723_17285</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CB01635</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the attachment of glycine to tRNA(Gly).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>ATP + glycine + tRNA(Gly) = AMP + diphosphate + glycyl-tRNA(Gly)</text>
            <dbReference type="Rhea" id="RHEA:16013"/>
            <dbReference type="Rhea" id="RHEA-COMP:9664"/>
            <dbReference type="Rhea" id="RHEA-COMP:9683"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78522"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.14"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.14" evidence="7"/>
    <dbReference type="EMBL" id="NNBL01000004">
        <property type="protein sequence ID" value="PJN10912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN10912">
        <property type="protein sequence ID" value="PJN10912"/>
        <property type="gene ID" value="CG723_17285"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004820">
        <property type="term" value="F:glycine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006426">
        <property type="term" value="P:glycyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00774">
        <property type="entry name" value="GlyRS-like_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.800">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00253_B">
        <property type="entry name" value="Gly_tRNA_synth_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002314">
        <property type="entry name" value="aa-tRNA-synt_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004154">
        <property type="entry name" value="Anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036621">
        <property type="entry name" value="Anticodon-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027031">
        <property type="entry name" value="Gly-tRNA_synthase/POLG2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022961">
        <property type="entry name" value="Gly_tRNA_ligase_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033731">
        <property type="entry name" value="GlyRS-like_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002315">
        <property type="entry name" value="tRNA-synt_gly"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10745">
        <property type="entry name" value="PTHR10745"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03129">
        <property type="entry name" value="HGTP_anticodon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00587">
        <property type="entry name" value="tRNA-synt_2b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01043">
        <property type="entry name" value="TRNASYNTHGLY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00389">
        <property type="entry name" value="glyS_dimeric"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="4 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 7 9" id="KW-0436">Ligase</keyword>
    <keyword evidence="3 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AA_TRNA_LIGASE_II" evidence="8">
        <location>
            <begin position="7"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="7">
        <location>
            <begin position="209"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="7">
        <location>
            <begin position="321"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="99"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="162"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="194"/>
            <end position="196"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="204"/>
            <end position="209"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="281"/>
            <end position="282"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="325"/>
            <end position="328"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PJN10912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="460" mass="52610" checksum="002F548020C303C6" modified="2018-04-25" version="1">MAADKIDTIVSLSKRRGFVYPCSEIYGGQRAAWDYGPLGVELKENLKRQWWRYMVTSREDVVGIDSSVILATEVWQASGHVATFTDPLTECTSCHKRYRADHLEEAYEAKHGKLPENGLTDLNCPNCGNKGTFTEPKQFSGLLSTHLGPTQDSGSIAYLRPETAQGIFTNFASVQQTSRRKPPFGIAQMGKSFRNEITPGNFIFRTREFEQMEMEFFVKPGEDEKWQEYWMEQRWNWYTGLGMREENMRWFEHPAEKLSHYSKRTADIEYRFRFGGNEWGELEGVANRTDYDLSAHSKASGQDLSYFDQEAGERYTPYVIEPAAGVGRSMLAFMLDAYVEDEAPNAKGKMEKRTVMRFDHRLAPVKVAVLPLSRNPELSPKAKGLATALRQNWNIDFDDAGAIGRRYRRQDEIGTPYCVTVDFDTLDDNAVTVRERDTMKQERVSLDQIEGYLATRLVGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-05-25" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JVV6</accession>
    <name>A0A2M9JVV6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CG723_17125</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">CB01635</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000004">
        <property type="protein sequence ID" value="PJN10887.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN10887">
        <property type="protein sequence ID" value="PJN10887"/>
        <property type="gene ID" value="CG723_17125"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04590">
        <property type="entry name" value="CBS_pair_CorC_HlyC_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002550">
        <property type="entry name" value="CNNM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044751">
        <property type="entry name" value="Ion_transp-like_CBS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005170">
        <property type="entry name" value="Transptr-assoc_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03471">
        <property type="entry name" value="CorC_HlyC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01595">
        <property type="entry name" value="DUF21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01091">
        <property type="entry name" value="CorC_HlyC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="SSF54631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="SSF56176"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51846">
        <property type="entry name" value="CNNM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0129">CBS domain</keyword>
    <keyword evidence="6 8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="10" id="KW-0732">Signal</keyword>
    <keyword evidence="2 8 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014857727" evidence="10">
        <location>
            <begin position="23"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="89"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="127"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="domain" description="CNNM transmembrane" evidence="12">
        <location>
            <begin position="1"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="11">
        <location>
            <begin position="204"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="11">
        <location>
            <begin position="268"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PJN10887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="427" mass="46155" checksum="8F61DB66DC520637" modified="2018-04-25" version="1">MSLSLVAGAVALVVVAWLAACAEAGIARTSSFRAEEAVRSGRRGSDRLAQVAADPTRYLNVALLVRVACEMAAASLVTYACLQEFDATWEALAVAIGVMVLVSYVAVGVSPRTIGRQHPLNTATAAAYVLLPLARIMGPIPPLLILIGNALTPGKGFRRGPFASEAELRAMVDLAEKESLIEDEERRMVHSVFELGDTLVREVMVPRTDLVAIERYKTIRQALTLALRSGFSRIPVTGESEDDVVGIVYLKDLARKTHISRDAESELVSTAMRPATFVPDTKNAGDLLREMQQLRNHVAVVIDEYGGTAGIVTIEDILEEIVGEITDEYDRELPPVQDLGDERFRVTARLDIGDLGELYGIEEYDDEDVETVGGLLAKALGRVPIAEASSVVELPDGRKLRLTAESAAGRRNKIVTVLVEPVGEEGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JWB5</accession>
    <name>A0A2M9JWB5_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DAO domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_09595</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN11190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN11190">
        <property type="protein sequence ID" value="PJN11190"/>
        <property type="gene ID" value="CG723_09595"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DAO" evidence="1">
        <location>
            <begin position="12"/>
            <end position="400"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN11190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="435" mass="46107" checksum="ED0A3665291CCD63" modified="2018-04-25" version="1">MNTLPSPAPKSVIVIGAGVIGLACAHYLRAAGLDVTVLERDRVGSGSSRGNAGEICPDLVEPLPAPGVITKALRGIHRPDSALHVHPRPNAELVRFLTGFARRANRRDHQHGAQALAGFAKDTFALFEELEQLGADGAARKDGYLFAFPSHEDAGRAHASFAALGAPLSADGVLDRADMATTEPALSDTAQAGFVVEDQWSVDPSRFVDGLAARLRDNGVHIVEGARVTSVDEVRGGVQVRSSAGTYGADRAVVAAGVWSQTLLRGLGVDPGLFPGKGYSFSVRSRQPLRRLVHLGTAHVVLTPLDETGERIRVAGTMEFEADADRYREARVRAVVAAARPYLEGADWADREEEWVGARPLTRDGLPLIGAVPGTSRIVAAGGHNMLGLMLAPVTGRAVAGLVTGDRAAAEATRPFTLERLARRPRTKRPATQRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JWF7</accession>
    <name>A0A2M9JWF7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_09900</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN11240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN11240">
        <property type="protein sequence ID" value="PJN11240"/>
        <property type="gene ID" value="CG723_09900"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="SSF49899"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014721797" evidence="2">
        <location>
            <begin position="49"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="286"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN11240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="347" mass="36725" checksum="3A91B3D57876FDDE" modified="2018-04-25" version="1">MARTAVGAPPEPRVGHTRSPRRTRRTALAAVALASVAVLAAAALPAQASGPAAKVPAQADGHAEHGSLRSHAVAAYDFGHPDPADPSKERDIGRSRTPLALINGGSAMRVADEAYPGSSPALQVRQQNPATAGNDDWKAGTWNEAGVGSLGAFNSAKAATVMGWFKMTGDNPTLNSNTANPTDRYGAIGLAGVLSGTSDGHAVRALLELIQVNGELKLVALGRRLDSGASQTFAASADWQQLLPRGEWVHLAATFDFRDGTMALYRDGKPLDGFYVTPGDPWELTTTPAPHRASPTDPRGIKIGGSFPQNTRENNACDCRMDDLLFLDRQMTAGQVRAEYRRMTRGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JWX0</accession>
    <name>A0A2M9JWX0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CG723_10740</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN11390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN11390">
        <property type="protein sequence ID" value="PJN11390"/>
        <property type="gene ID" value="CG723_10740"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015833">
        <property type="term" value="P:peptide transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013563">
        <property type="entry name" value="Oligopep_ABC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08352">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01727">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="10"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="45"/>
            <end position="52"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PJN11390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="322" mass="33871" checksum="36EBE653F279F225" modified="2018-04-25" version="1">MTGPQPVLSVRDLSVRFRMRDGAYVQAVSGARLDLAAGECLALVGESGCGKSVLASALLGLLPGNAETAGSAFIGGLDLLAADERTLARTVRGRRVGLVPQSPAAHLTPVRTVRSQLEEIVRELTGVRRGPRLRAAAEEAAERAAFPAGHLDRYPHELSGGLAQRAATALALVGDAPLLLADEPTTGLDRDLVERTVDELRRHIGAERALLLITHDLVAAERIADRVAVMYASRIVELADAADFFGSPGPRHPYARGLLDALPDREFTPIPGMPPELGALPAGCAFAARCDRATDTCEARPALADGVACHHPATVPLEAPRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JX07</accession>
    <name>A0A2M9JX07_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">FAD-binding oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_10985</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN11431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN11431">
        <property type="protein sequence ID" value="PJN11431"/>
        <property type="gene ID" value="CG723_10985"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.45.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016164">
        <property type="entry name" value="FAD-linked_Oxase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004113">
        <property type="entry name" value="FAD-linked_oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016171">
        <property type="entry name" value="Vanillyl_alc_oxidase_C-sub2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02913">
        <property type="entry name" value="FAD-oxidase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55103">
        <property type="entry name" value="SSF55103"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="SSF56176"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="1">
        <location>
            <begin position="52"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN11431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="487" mass="53458" checksum="8E5ED8E5A1FA064B" modified="2018-04-25" version="1">MVQSASKLNREEIVDRLTSLVGAGAVVTDEQQLREASVDRFKKYQAVHGIYDAPPPAAIVNATSVDDVSKVLAFADENRINIVARTGRTGTEGGLETAVTDTIVLDGSGLDEIIKIDEENMQVTAGCGVQLQVLEDTLRAKGYTTGHSPQSKPLAQMGGLVSTRSIGQFSTLYGAIEDMVVGLEAVFPDGTVSRIKNVPRRATGPDIRHIVIGNEGALCYITEVTVKIFKYQPENNEFHGFLVDDMATGTAIIREVVVGGFKPSVVRVYSPEDAGQHFSHFSKGKCVVVFVAEGPKGIVRATSEEIERVADRFAHEKVDPKLIEAWFDNLNWGPDKIEAEKEVMRAKAELGYTTEVSCDWSKVTELYGAVMNRIRTEYPHADDLTLLGAHSSHSYQTGTNLYFVYDYKINCEPEEEIGKYHVPLNAIIVEEALRVGGSMVHHHGVGKYRTAWTKQEHGSAYHMLAKLKEAFDPNGIMNKGTIFPLDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JX11</accession>
    <name>A0A2M9JX11_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">IS200/IS605 family transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_11020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN11436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN11436">
        <property type="protein sequence ID" value="PJN11436"/>
        <property type="gene ID" value="CG723_11020"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1290">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002686">
        <property type="entry name" value="Transposase_17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036515">
        <property type="entry name" value="Transposase_17_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01797">
        <property type="entry name" value="Y1_Tnp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01321">
        <property type="entry name" value="Y1_Tnp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143422">
        <property type="entry name" value="SSF143422"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Y1_Tnp" evidence="1">
        <location>
            <begin position="14"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM01321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN11436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="138" mass="16116" checksum="70296C816061DA6F" modified="2018-04-25" version="1">MAEMQKIRTGRHCAFMMHVHLVFVTKFRHDVFTDVHLRRMEEIMRAVCSDFECELVEFNGEDNHVHLLVNFPPKVAVAKLVNSLKGVSSRRLRQEFPDLVRHYWRANKLWSGSDFADTVGGAPLSIVRQYIEQQNHPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JX29</accession>
    <name>A0A2M9JX29_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Acetoacetate--CoA ligase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CG723_11115</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN11451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN11451">
        <property type="protein sequence ID" value="PJN11451"/>
        <property type="gene ID" value="CG723_11115"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030729">
        <property type="term" value="F:acetoacetate-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005914">
        <property type="entry name" value="Acac_CoA_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032387">
        <property type="entry name" value="ACAS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16177">
        <property type="entry name" value="ACAS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01217">
        <property type="entry name" value="ac_ac_CoA_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0436">Ligase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ACAS_N" evidence="3">
        <location>
            <begin position="26"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding" evidence="1">
        <location>
            <begin position="85"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding_C" evidence="2">
        <location>
            <begin position="532"/>
            <end position="606"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF16177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PJN11451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="649" mass="70059" checksum="95AA3C383CC4C151" modified="2018-04-25" version="1">MSARNSNVTEFLGWLAQERGLSFTDYAELWRWSTDDLLGFWSAVWEFYGLDTVSDYDEVLADARMPGATWFTGARLNFAQQCLARATDERPALIAVSETGDAVEISWDRLTQEVAGTAAALREMGVGPGDCVAGYLPNIPQAVVALLATAAVGATWTVCSPEFGTPSVLARLRQARPTVLVAADGYAHGGKEYDRRPHIAEILDGLPTVRHLVAVDRLHASAGGPASSRRPDVTQHTWSDLADREAQLTYADVAFDHPLWILWSSGTTGVPKGIVHGHGGIVVELLKALGLGVDLRADDRYLFHTSTSWMVWNFMVGGLLHGSTLVLYDGSPTHPDVDGLWRIAERTRATTVGVGAAYLIAAEKAGAHPAAATDLGALRTVLQTGSAMPDSTWRWVHDRLAPKARLQSICGGTDICSVLAGDSPLLPVRTGRISGPSLGVALASWDATGRPLVGEQGELVVTAPLPSMPLRFVDDPDHERYRSSYFDVYPGVWRHGDWVTMNPDLSVVVAGRSDSTLNRMGVRMGSADLYAVVERLPRIADSLVIGAELADGRYYMPLFVVPADGERFDDALRAEIVGAIRHSLSPRHVPDDVVPIEAVPRTLTGKKLEVPVKRILQGTRVSEVSAEGAVTRPDMLAWFAEFAAGLGQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JX78</accession>
    <name>A0A2M9JX78_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Acetamidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CG723_11360</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN11494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN11494">
        <property type="protein sequence ID" value="PJN11494"/>
        <property type="gene ID" value="CG723_11360"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016811">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004304">
        <property type="entry name" value="FmdA_AmdA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31891">
        <property type="entry name" value="PTHR31891"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03069">
        <property type="entry name" value="FmdA_AmdA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PJN11494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="343" mass="37778" checksum="27D572370F63775E" modified="2018-04-25" version="1">MNDPRILTVRPEPGEYAYTFGGAPPIARIVPGTVLDLYTEDCFDGRVRSEKDLVSQVCEFPFLNPQTGPFHIEGAEPGDTVAVHFVSVEPARDWAASTTVPLFGALTSTHTTATLQPPLPEVVWMWHLDRERRTTRFTAHDSDFQVELPMDPMHGTVGVAPANLEVRSALVPDAHGGNMDSPEMRAGVTCYLGVNVEGALLSLGDGHARQGEGETCGVAVECAMRTVVIVELLKGVATPWPRIESDTHIISTGSARPLEDAFRISQLDLVRWLERDYGFSELDAYQFASQTVESPLANVCDTNYTCVAKLRKEWLPARETHRGLHAHLRDVAATLPRPDHRTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-09-29" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JXA3</accession>
    <name>A0A2M9JXA3_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Glutathione peroxidase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CG723_11430</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CB01635</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the glutathione peroxidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN11506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN11506">
        <property type="protein sequence ID" value="PJN11506"/>
        <property type="gene ID" value="CG723_11430"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004602">
        <property type="term" value="F:glutathione peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00340">
        <property type="entry name" value="GSH_Peroxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000889">
        <property type="entry name" value="Glutathione_peroxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029759">
        <property type="entry name" value="GPX_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11592">
        <property type="entry name" value="PTHR11592"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00255">
        <property type="entry name" value="GSHPx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000303">
        <property type="entry name" value="Glutathion_perox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01011">
        <property type="entry name" value="GLUTPROXDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00460">
        <property type="entry name" value="GLUTATHIONE_PEROXID_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51355">
        <property type="entry name" value="GLUTATHIONE_PEROXID_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2 5 6" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" evidence="4">
        <location>
            <position position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000303-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PJN11506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="163" mass="17586" checksum="C6B4059CBC3EA069" modified="2018-04-25" version="1">MSVYENVEIAALQGGPADLPQYEGKAVLIVNVASKCGLTPQYAALEQLHAEYASRGFSVLGVPCNQFMGQEPGSAEEIAEFCSATYGVTFPMTEKVEVNGDARHPLYERLVTTADAEGHDGDIRWNFEKFVLSPKGEVVARFSPQVVPDAPEVLAAIEANLPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JXB0</accession>
    <name>A0A2M9JXB0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_11550</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN11529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN11529">
        <property type="protein sequence ID" value="PJN11529"/>
        <property type="gene ID" value="CG723_11550"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="SSF48264"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0349">Heme</keyword>
    <keyword evidence="1" id="KW-0408">Iron</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN11529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="493" mass="54417" checksum="0F1F78D12A475465" modified="2018-04-25" version="1">MAQLTQPATDSTPPKGFRSAELGWPGLDRIPHPPRRVPFVGDILGANVRTPVQDSMRIGKELGPVFRRKAFGNEIVFVWGTRFAADMADESRFAKHVGLGVANLRPMAGDGLFTAYNHEPNWQLAHDVLAPGFGRDAMEGYHPLMLDVAGRLTAAWDAREAAGEAVDVPGDMTKLTLETIARTGFGHDFGSFERERPHPFVTAMVGTLSFAQRRNVVPPALAPLLLRSAERRNAADMAYLNRTVDDVVAARRAASGSRTGGQGDLLDRMLEVAHPDTGERLSPENIRRQVITFLVAGHETTSGALSFALHYLAHHPDVLAKAREEVERVWGDADEPAYEQVAKLRYLRRVLDESLRLWPTAPAFAREATVDTTLGGIHPMRRGAWALVLTALLHRDPEAWGDDPEAFDPDRFAPAAVRSRAPHVFKPFGTGARACIGRQFALHEATLVLGLLLRRYDLHPEPGYRLRVAERLTLMPEGLRLNLGRRAKVRTAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JXJ2</accession>
    <name>A0A2M9JXJ2_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Phosphate-binding protein PstS</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">pstS</name>
        <name evidence="7" type="ORF">CG723_11985</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CB01635</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Part of the ABC transporter complex PstSACB involved in phosphate import.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">The complex is composed of two ATP-binding proteins (PstB), two transmembrane proteins (PstC and PstA) and a solute-binding protein (PstS).</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the PstS family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN11601.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN11601">
        <property type="protein sequence ID" value="PJN11601"/>
        <property type="gene ID" value="CG723_11985"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042301">
        <property type="term" value="F:phosphate ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035435">
        <property type="term" value="P:phosphate ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005673">
        <property type="entry name" value="ABC_phos-bd_PstS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024370">
        <property type="entry name" value="PBP_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12849">
        <property type="entry name" value="PBP_like_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002756">
        <property type="entry name" value="PstS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00975">
        <property type="entry name" value="3a0107s03"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0592">Phosphate transport</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014689695" description="Phosphate-binding protein PstS" evidence="5">
        <location>
            <begin position="24"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="domain" description="PBP_domain" evidence="6">
        <location>
            <begin position="50"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="region of interest" description="Phosphate binding" evidence="4">
        <location>
            <begin position="58"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Phosphate binding" evidence="4">
        <location>
            <begin position="194"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="88"/>
        </location>
        <ligand>
            <name>phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="106"/>
        </location>
        <ligand>
            <name>phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR002756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR002756-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF12849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PJN11601.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="371" mass="37849" checksum="D402214B42C973E9" modified="2018-04-25" version="1">MIKRSAPAGVASLAAVLLLAGCGAGGPGDSDDQASSAGASPVADIDCAGKSQVPGSGSTAQQNVMKYWIDQYQRACPGVQIAYNPLGSGAGAAQFLRGATAFGGSDSALKPEEVELSKQTCTEGRAINLPMAGGPIAVGYNLPGVDDLVLDAATLAKIFDTRITTWDAPEIRALNPGAELPSTRIRPVHRSDDSGTTQNLQAYLAGAAPAAWPYSAEKSWQGTGGGSANGSSGVVSQVNSSYGSIGYFELSFAASSQVPTVSIDTGTAEPVAPSPESASAGIAAARVAGEGKDMSLKFRYGHSAAGAYPIVLVTYEIVCDKGNRAATLPALKSFLTYTASDEGQQALTRIHYAPLPDTVATQVRETVQSLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JYC8</accession>
    <name>A0A2M9JYC8_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">S-adenosyl-L-methionine-dependent methyltransferase</fullName>
            <ecNumber evidence="4">2.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CG723_13075</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CB01635</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 4">Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the UPF0677 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-" evidence="4"/>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN11777.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN11777">
        <property type="protein sequence ID" value="PJN11777"/>
        <property type="gene ID" value="CG723_13075"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011610">
        <property type="entry name" value="CHP00027_methylltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007213">
        <property type="entry name" value="Ppm1/Ppm2/Tcmp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04072">
        <property type="entry name" value="LCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00027">
        <property type="entry name" value="mthyl_TIGR00027"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003907"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU362030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PJN11777.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="285" mass="31271" checksum="F8601559D29EFE50" modified="2018-04-25" version="1">MADERNEVPDSSAVRVALWRALHVRIDAPPHVFEDEVGLELAAPEAGWQDRPDMDPHATSGFRAAIVSRARFVEDLIDERIDDGITQYVVLGAGLDTFAQRRPDVAGHLRVFEIDQPATQAWKRRRLIEVGYGVPDWLRLMPVDFEAGEDWWEQLSGAGFDSARPAVVVCTGVSMYLTKDATAATLRRLAGLAPGSTLAMTFMLPAELVDDADRPALEATEPQAQAAGTPFISFYTPKEMLELAHDAGFKDVRHVAGTTLADRYFADRPDGLRPSSGEDLLVATT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JYG4</accession>
    <name>A0A2M9JYG4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">TetR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_13935</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN11919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN11919">
        <property type="protein sequence ID" value="PJN11919"/>
        <property type="gene ID" value="CG723_13935"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="15"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="36"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN11919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="195" mass="20839" checksum="C8563C24A812E748" modified="2018-04-25" version="1">MALPAPAKPLRADAERTVRAILEAAERVLSANPAATMEQVAEAAGVARTTVHRRFASRDALITALATWATQRFYEAVEAARPETAPPAIALYQVTANVLRVKIGWGFAMGAEPTGAPEAARVHAEVLARCELLFARARDAGLLAPDTDLDWARRVYYALIHEAAAEAPDTDAAVDALATRVVDTLLYGIGRPATR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JYK7</accession>
    <name>A0A2M9JYK7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CG723_14200</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN11963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN11963">
        <property type="protein sequence ID" value="PJN11963"/>
        <property type="gene ID" value="CG723_14200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PJN11963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="73" mass="7940" checksum="90EEFB585BBF6EED" modified="2018-04-25" version="1">MSVNLVVLGKEGQTSEHQGEVLHFVDGKEGKFSYSIDAGALLVWKADPRAETRVEVAYAPHAWIKASGARKDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JZ20</accession>
    <name>A0A2M9JZ20_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Cobalt-precorrin-5B C(1)-methyltransferase</fullName>
            <ecNumber evidence="5">2.1.1.195</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Cobalt-precorrin-6A synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">cbiD</name>
        <name evidence="7" type="ORF">CG723_09835</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CB01635</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>Co-precorrin-5B + S-adenosyl-L-methionine = Co-precorrin-6A + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:26285"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:60063"/>
            <dbReference type="ChEBI" id="CHEBI:60064"/>
            <dbReference type="EC" id="2.1.1.195"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="5">Cofactor biosynthesis; adenosylcobalamin biosynthesis; cob(II)yrinate a,c-diamide from sirohydrochlorin (anaerobic route): step 6/10.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the CbiD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.195" evidence="5"/>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN12125.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN12125">
        <property type="protein sequence ID" value="PJN12125"/>
        <property type="gene ID" value="CG723_09835"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00148">
        <property type="reaction ID" value="UER00227"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043780">
        <property type="term" value="F:cobalt-precorrin-5B C1-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009236">
        <property type="term" value="P:cobalamin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046140">
        <property type="term" value="P:corrin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00787">
        <property type="entry name" value="CbiD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002748">
        <property type="entry name" value="CbiD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036074">
        <property type="entry name" value="CbiD_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35863">
        <property type="entry name" value="PTHR35863"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01888">
        <property type="entry name" value="CbiD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF026782">
        <property type="entry name" value="CbiD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111342">
        <property type="entry name" value="SSF111342"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5" id="KW-0169">Cobalamin biosynthesis</keyword>
    <keyword evidence="2 5 7" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3 5 7" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PJN12125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="370" mass="37550" checksum="CECF3CE00C866CAF" modified="2018-04-25" version="1">MSEAGGAKGGRGAQLKHTGLRPGWTTGACATGAATAAYTALLTGDFPDPVTITLPKGQTPAFALAAEELTREHAMAAIVKDAGDDPDVTHGALVRASVRLLPAGAGVAFRAGPGVGTVTRPGLPLAVGEPAINPVPRQMMRDHVAAVAERHGGSGDVEITVSVDHGEEIARSTWNPRLGILGGLSVLGTTGIVVPYSCSAWIDSIRRGVDVARAAGRTHVAGCTGSTSEKTVVAEYGLPEDALLDMGDFAGAVLKYVRRHPVDRLTVCGGFAKLSKLAAGHLDLHSARSQVDKSFLAGLAAEAGAGAEVAAAVADANTGLAALQLWPPLGDLVAATARDEALRVLRGAPVQVDVLCIDRAGAVVGRCAPC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JZ76</accession>
    <name>A0A2M9JZ76_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_12090</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN12174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN12174">
        <property type="protein sequence ID" value="PJN12174"/>
        <property type="gene ID" value="CG723_12090"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002577">
        <property type="entry name" value="HTH_HxlR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01638">
        <property type="entry name" value="HxlR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51118">
        <property type="entry name" value="HTH_HXLR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH hxlR-type" evidence="2">
        <location>
            <begin position="11"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="136"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN12174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="165" mass="19173" checksum="29A0AEFA9D94929F" modified="2018-04-25" version="1">MRRTSFANWPCSIARTMDLLGDWWTPLVLREAFYGIKRFDVFQEELGIARNTLADRLRRLVDEGLMEKRAYQQEPVRYDYVLTDMGRDFFGVLAAMNRWGDRWLAEEAGPPVVFHHDRCGHEGHAEVVCSECKEPMTAENTRPRLGPGYPPRLAERPDIKARFAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JZG8</accession>
    <name>A0A2M9JZG8_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Assimilatory sulfite reductase (ferredoxin)</fullName>
            <ecNumber evidence="5">1.8.7.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">CG723_04140</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">CB01635</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the reduction of sulfite to sulfide, a step in the biosynthesis of sulfur-containing amino acids and cofactors.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>3 H2O + hydrogen sulfide + 6 oxidized [2Fe-2S]-[ferredoxin] = 7 H(+) + 6 reduced [2Fe-2S]-[ferredoxin] + sulfite</text>
            <dbReference type="Rhea" id="RHEA:23132"/>
            <dbReference type="Rhea" id="RHEA-COMP:10000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10001"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17359"/>
            <dbReference type="ChEBI" id="CHEBI:29919"/>
            <dbReference type="ChEBI" id="CHEBI:33737"/>
            <dbReference type="ChEBI" id="CHEBI:33738"/>
            <dbReference type="EC" id="1.8.7.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 12">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">Nitrogen metabolism; nitrate reduction (assimilation).</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.8.7.1" evidence="5"/>
    <dbReference type="EMBL" id="NNBL01000002">
        <property type="protein sequence ID" value="PJN12260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN12260">
        <property type="protein sequence ID" value="PJN12260"/>
        <property type="gene ID" value="CG723_04140"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00653"/>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008942">
        <property type="term" value="F:nitrite reductase [NAD(P)H] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050311">
        <property type="term" value="F:sulfite reductase (ferredoxin) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042128">
        <property type="term" value="P:nitrate assimilation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.413.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007419">
        <property type="entry name" value="BFD-like_2Fe2S-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041854">
        <property type="entry name" value="BFD-like_2Fe2S-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016156">
        <property type="entry name" value="FAD/NAD-linked_Rdtase_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005117">
        <property type="entry name" value="NiRdtase/SiRdtase_haem-b_fer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036136">
        <property type="entry name" value="Nit/Sulf_reduc_fer-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012744">
        <property type="entry name" value="Nitri_red_NirB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017121">
        <property type="entry name" value="Nitrite_Rdtase_lsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006067">
        <property type="entry name" value="NO2/SO3_Rdtase_4Fe4S_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045854">
        <property type="entry name" value="NO2/SO3_Rdtase_4Fe4S_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006066">
        <property type="entry name" value="NO2/SO3_Rdtase_FeS/sirohaem_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041575">
        <property type="entry name" value="Rubredoxin_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04324">
        <property type="entry name" value="Fer2_BFD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01077">
        <property type="entry name" value="NIR_SIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03460">
        <property type="entry name" value="NIR_SIR_ferr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18267">
        <property type="entry name" value="Rubredoxin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037149">
        <property type="entry name" value="NirB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00397">
        <property type="entry name" value="SIROHAEM"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55124">
        <property type="entry name" value="SSF55124"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56014">
        <property type="entry name" value="SSF56014"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02374">
        <property type="entry name" value="nitri_red_nirB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00365">
        <property type="entry name" value="NIR_SIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9 12" id="KW-0274">FAD</keyword>
    <keyword evidence="7 12" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6" id="KW-0349">Heme</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11 12" id="KW-0534">Nitrate assimilation</keyword>
    <keyword evidence="10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0883">Thioether bond</keyword>
    <feature type="domain" description="Pyr_redox_2" evidence="16">
        <location>
            <begin position="7"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="domain" description="Rubredoxin_C" evidence="17">
        <location>
            <begin position="327"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="domain" description="Fer2_BFD" evidence="15">
        <location>
            <begin position="426"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="domain" description="NIR_SIR_ferr" evidence="14">
        <location>
            <begin position="561"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="domain" description="NIR_SIR" evidence="13">
        <location>
            <begin position="633"/>
            <end position="769"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00003247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012353"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022784"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRNR" id="PIRNR037149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF01077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF03460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF04324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF18267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="PJN12260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="851" mass="90214" checksum="D065347D264D2ABF" modified="2018-04-25" version="1">MPTTPTLVLVGHGMVGQRFLEALAERGLTDTHRVVVLCEEPRPAYDRVQLTSYFSGRTPDELSLTDAEFIARHGIELHLGDPAEHIDRDTRTVTARSGLQVTYDALVLATGSYPFVPPVPGKDATGCFVYRTIEDLLAIEEYAKKHATTGAVVGGGLLGLEAAGALRGLGLDTHVVEFAPRLMPVQVDEGGGAALLRTITGMGLSVHTGVGTQEILTEGPDGTAGAVRAMKLSDGSELATDLVVFSAGVRPRDQLARDMGLTVGERGGITVDERCRTSDPAVYAIGECAQAVDGRVYGLVAPGYEMAQTAAASIASEEGQFTGADLSTKLKLLGVDVASFGDAHGAADGCLDVVYSDSRSGTYKKLVVGPEGELLGGILVGDAEAYGTLRALTGSVPPVAPEQLVLPAGAGAPVALGPEALPGDAVICSCHNVTKEEIQAHATLPEVKKCTKAGTGCGSCVKLIGQLLPQSGDKGLCGCFPHTRAELYEIVRVKRIASYADLLDAHGRDGARGGEGCEVCKPAVGSIIASLAPTIGADGHVLDGEQAALQDTNDHFLANLQKNGSYSVVPRIPGGEVTPEKLIVIGEVARDFGLYTKITGGQRIDLFGARVEQLPLIWTRLVDAGFESGHAYGKALRTVKSCVGQTWCRYGVQDSVRMAIDLELRYRGLRAPHKLKSAVSGCGRECAEAQSKDFGVIATANGWNLYVGGNGGATPRHADLLAQDLSDAELIRLIDRFLMFYIRTADRLERTAGWLQRIEGGLDHVRDVVVHDSLGLCDELEALMADHVAHYRDEWADTLDDPERLERFVSFVNAPDAPDPLVRFVPERDQIKPDLPLLSIGSRPLEGSVTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JZH8</accession>
    <name>A0A2M9JZH8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">TetR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_04130</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000002">
        <property type="protein sequence ID" value="PJN12258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN12258">
        <property type="protein sequence ID" value="PJN12258"/>
        <property type="gene ID" value="CG723_04130"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011075">
        <property type="entry name" value="TetR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16925">
        <property type="entry name" value="TetR_C_13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="6"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="29"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN12258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="202" mass="21860" checksum="EA519DAA498E0F81" modified="2018-04-25" version="1">MARTKEFDPDAALQSALELFWRRGYEATSMADLVDHLGIGRASIYATFGNKHEMYLKAMDRYAESADAAILADLSAGGPALPAVRGLVRRFAAEATADERRLTGCFVTNTATELAPHDTAAARRVERSWEHIETLLQATLTRARAQGELPADRDPRALARLLLVLMQGMRVVGKASSDPGRVRDAAEQALGLLDRAAAPVSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JZQ9</accession>
    <name>A0A2M9JZQ9_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">SGNH_hydro domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CG723_04495</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000002">
        <property type="protein sequence ID" value="PJN12320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN12320">
        <property type="protein sequence ID" value="PJN12320"/>
        <property type="gene ID" value="CG723_04495"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004620">
        <property type="term" value="F:phospholipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038885">
        <property type="entry name" value="PLB1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013830">
        <property type="entry name" value="SGNH_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21325">
        <property type="entry name" value="PTHR21325"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13472">
        <property type="entry name" value="Lipase_GDSL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015006597" description="SGNH_hydro domain-containing protein" evidence="4">
        <location>
            <begin position="32"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="domain" description="SGNH_hydro" evidence="5">
        <location>
            <begin position="67"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="38"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF13472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PJN12320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="306" mass="32658" checksum="050A568F0153E7B1" modified="2018-04-25" version="1">MRIRSHRSAAVRAAVAGATAVLLGAAGLAACDAIGDNSPGPEGSTAGTKPSPKPTPRWDTSPRSVAAVGDSITRGFDACSVLTDCPEVSWATGSDTGVRSLAVRLLGKDRAATHSWNFARTGARMADLPAQMEQAAAVSPGLVTVMAGANDACRPTPATMTPVDTFRADFEEAMHTLRREVPKAQVYVSSVPDLKRLWSAGRTNPLGKQVWKLGICSSMLADPDDLAAAATQRRASVQDRVVAYNEVLADVCAKDRRCRYDGGAVFAYRFDGKQLSHWDWFHPSKDGQSRLAAMAYRRVTAKEPIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JZS4</accession>
    <name>A0A2M9JZS4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Short-chain dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CG723_04125</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000002">
        <property type="protein sequence ID" value="PJN12257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN12257">
        <property type="protein sequence ID" value="PJN12257"/>
        <property type="gene ID" value="CG723_04125"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PJN12257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="255" mass="25596" checksum="73D4CD1852AA0EC7" modified="2018-04-25" version="1">MSRSRFAGRNVLVTGAGTGLGRAIALAFAAEGARVVVAGRTRATLDATVDLIEAAGGTAVAHTADVSRAGDLQDLVRAIVERFGSLDVAVNNAGVFRGAGPVAELASGDWQTMLDINVTGVLLALQAEVAQMRTQERGGAIVNISSNLGSHKSRAGVTGYAVSKAAVSALTRGAALDHIGDGVRINAVSPGPSATAMSLLPGETEAERAVRMKEQSPLGRVSAPDEVAAAVLYLASEDAASVVGADLVIDGGSAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JZV4</accession>
    <name>A0A2M9JZV4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Acyl-CoA synthetase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_04310</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000002">
        <property type="protein sequence ID" value="PJN12287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN12287">
        <property type="protein sequence ID" value="PJN12287"/>
        <property type="gene ID" value="CG723_04310"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-binding" evidence="1">
        <location>
            <begin position="9"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding_C" evidence="2">
        <location>
            <begin position="397"/>
            <end position="473"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN12287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="482" mass="50410" checksum="9A8D055788C4A59A" modified="2018-04-25" version="1">MSLLFPALAHDPDRPALRFGDRSLTYGELASAAGALAARLDGASRAAVWATPTLETAVGVVAALLAGVPAVPLNPKSGGGELAHIVADSAPDVVLAAPGTELPDALGDLRFVGIDVDASGPAREWPEPDASAPAFVVYTSGTTGPPKGAVLPRRAVTSTLDALQDAWEWTGDDVLVHGLPLFHVHGLILGILGPLRRGGSVRHLGRFSTEGVARELGSGATMLFGVPTMYHRIAEALPAEPELVKALSGARLLVSGSAALPVHDHERIAAATGRRVIERYGMTETLMNTSVRADGEARAGTVGVPLPGVSVRLVEDDGVTEIPAGDPEAVGEIQVRGPNLFTEYLNRPDATAGAFAEGGWFRTGDMAVRDPDGYVRIVGRKATDLIKSGGYKIGAGEIENALLEHPGVSEAAVTGEPDDDLGERIVAWIVPADAERPPAADELASHVADRLAPHKRPRVVRYLEALPRNDMGKIMKRALPRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-06-02" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JZX4</accession>
    <name>A0A2M9JZX4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_05015</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000002">
        <property type="protein sequence ID" value="PJN12408.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN12408">
        <property type="protein sequence ID" value="PJN12408"/>
        <property type="gene ID" value="CG723_05015"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035166">
        <property type="entry name" value="DUF5336"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17270">
        <property type="entry name" value="DUF5336"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="49"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="79"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="117"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="161"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="269"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="202"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN12408.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="289" mass="29187" checksum="D4C3F2520859D83A" modified="2018-04-25" version="1">MNIRSLTRGDGVVIGAAVLLFIASFLDIYSIDGNSSNESLPNAWESAPLLFSVFLAGVIAAVLIVVARGLPSVPKVAGLDLGQFGIALAVFAAWSALGNIFDPAGGWNNIGTFPDDAFGAGTGAILGLIAALVLAGAAVATPLVPALKGALVGAPRPQAPQPYGAQPAGAYGYPGAQQPGQPYGAQPGQPGQPGQPGQPGQPYGAAQPQQQAAPAPQAAQAPAGDFSPFWFAVPVPRPLYAEDGSPTPIAELAPGTWYLAVEQRGPGLVAQTQDGRRGVLQDTTGIQRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JZZ6</accession>
    <name>A0A2M9JZZ6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">3-oxoacyl-ACP reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_05130</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000002">
        <property type="protein sequence ID" value="PJN12428.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN12428">
        <property type="protein sequence ID" value="PJN12428"/>
        <property type="gene ID" value="CG723_05130"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN12428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="316" mass="32786" checksum="9F08700446700A77" modified="2018-04-25" version="1">MASESLPLQGLSAIVTGAGRGLGRAEALELARLGASVVVNDFGQPGRDGSGGADATPAEEVAAEIRAAGGQAVSHLGDVADHEQARALVQLAVDTYGKLDILVNNAGILRDRMIFSMSEDEWDSVIRVHLKGHFNTSHFASVHWRARSKAAGAPVYGRIVNTSSEAFLAGSAGQPNYAAAKGGIVGLTTSSALALGKYGVTANVICPRARTRMTEDVFAGFAEPGAGELDPLAPEHVAPLVGYLASPAAGNVNGQLLVVHGGMVAVVERPKVSAKFDTEKDAFSYEELDALLTPHYADRPPNETFAAAEVLGLKHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K005</accession>
    <name>A0A2M9K005_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 6">Glutamine-dependent NAD(+) synthetase</fullName>
            <ecNumber evidence="5 6">6.3.5.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5 6">NAD(+) synthase [glutamine-hydrolyzing]</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">nadE</name>
        <name evidence="11" type="ORF">CG723_05385</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CB01635</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5 6">
            <text>ATP + deamido-NAD(+) + H2O + L-glutamine = AMP + diphosphate + H(+) + L-glutamate + NAD(+)</text>
            <dbReference type="Rhea" id="RHEA:24384"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:58437"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.3.5.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 5 6">Cofactor biosynthesis; NAD(+) biosynthesis; NAD(+) from deamido-NAD(+) (L-Gln route): step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the NAD synthetase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 5 6">In the C-terminal section; belongs to the NAD synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.1" evidence="5 6"/>
    <dbReference type="EMBL" id="NNBL01000002">
        <property type="protein sequence ID" value="PJN12472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN12472">
        <property type="protein sequence ID" value="PJN12472"/>
        <property type="gene ID" value="CG723_05385"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00253">
        <property type="reaction ID" value="UER00334"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004359">
        <property type="term" value="F:glutaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003952">
        <property type="term" value="F:NAD+ synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008795">
        <property type="term" value="F:NAD+ synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000257">
        <property type="term" value="F:nitrilase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009435">
        <property type="term" value="P:NAD biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00553">
        <property type="entry name" value="NAD_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02090">
        <property type="entry name" value="NadE_glutamine_dep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003010">
        <property type="entry name" value="C-N_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036526">
        <property type="entry name" value="C-N_Hydrolase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014445">
        <property type="entry name" value="Gln-dep_NAD_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022310">
        <property type="entry name" value="NAD/GMP_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003694">
        <property type="entry name" value="NAD_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000132">
        <property type="entry name" value="Nitrilase/CN_hydratase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23090">
        <property type="entry name" value="PTHR23090"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00795">
        <property type="entry name" value="CN_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02540">
        <property type="entry name" value="NAD_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006630">
        <property type="entry name" value="NADS_GAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56317">
        <property type="entry name" value="SSF56317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00552">
        <property type="entry name" value="nadE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50263">
        <property type="entry name" value="CN_HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00920">
        <property type="entry name" value="NITRIL_CHT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 6 8" id="KW-0436">Ligase</keyword>
    <keyword evidence="5 6 8" id="KW-0520">NAD</keyword>
    <keyword evidence="3 5 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CN hydrolase" evidence="10">
        <location>
            <begin position="4"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="475"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="7">
        <location>
            <position position="44"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor; for glutaminase activity" evidence="5">
        <location>
            <position position="44"/>
        </location>
    </feature>
    <feature type="active site" description="For glutaminase activity" evidence="5">
        <location>
            <position position="126"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile; for glutaminase activity" evidence="5">
        <location>
            <position position="162"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="132"/>
        </location>
        <ligand>
            <name>L-glutamine</name>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="189"/>
        </location>
        <ligand>
            <name>L-glutamine</name>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="195"/>
        </location>
        <ligand>
            <name>L-glutamine</name>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="331"/>
            <end position="338"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="408"/>
        </location>
        <ligand>
            <name>deamido-NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58437"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="437"/>
        </location>
        <ligand>
            <name>deamido-NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58437"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="553"/>
        </location>
        <ligand>
            <name>deamido-NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58437"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR006630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PJN12472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="584" mass="62863" checksum="206395A78F53FDA8" modified="2018-04-25" version="1">MPQLRLALNQIDSTVGDLAGNAEAIIRWTKHSAEQGAHLVAFPEMVLTGYPVEDLALRESFVEASRQGLTALARRLADEGHGDLPVIVGYLDRSEKAQPKYGQPAGAPQNAAAVLHNGRVALTFAKHHLPNYGVFDEFRYFVPGDTMPVIRVRGIDVALAICEDLWQDGGRVPATRSAGAGLLISINASPYEQNKDDTRLDLVRKRAQEAGCTLAYVATIGGQDELVFDGDSIVVDAAGEVVARAPQFAEGCVVLDLDLPAAKPEAPTGTVDDGLRIDHLTISEDHVPAYEPELTGGYADRLDDDEEVYSALVVGLRAYAAKNGFRSVLIGLSGGIDSALTAAIACDALGAQNVYGIAMPSKYSSDHSKGDAAELADRTGLNFRTVPIEPMFDAYMGSLGLTGLAEENLQSRLRGTMLMAVSNQEGHIVLAPGNKSELAVGYSTLYGDSVGAYGPIKDVYKTSVFRLAEWRNRAAAERGQTPPIPENSITKPPSAELRPDQVDTDSLPDYPVLDAILELYVDRDRGADAIVAAGFDADLVTRTLRMVDTAEYKRRQYPPGTKISAKGFGKDRRLPITNRWRESA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K036</accession>
    <name>A0A2M9K036_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CG723_05365</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CB01635</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000002">
        <property type="protein sequence ID" value="PJN12468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN12468">
        <property type="protein sequence ID" value="PJN12468"/>
        <property type="gene ID" value="CG723_05365"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004638">
        <property type="entry name" value="EmrB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00711">
        <property type="entry name" value="efflux_EmrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="21"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="65"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="93"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="118"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="152"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="178"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="212"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="244"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="283"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="311"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="344"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="371"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="418"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="489"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="23"/>
            <end position="513"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PJN12468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="530" mass="55395" checksum="5C3EED27A1249F65" modified="2018-04-25" version="1">MTTPAVPESPRIPEAVHRRRWAILGVLMLSLLIVVLDNSILNVAIKTISTPPPVGLGATQGELEWAINAYTLVFAGLLFTAGLLGDRLGRKKVLVFGLVVFGLGSALAAESGSPVQLIIFRAIMGIGAAFVMPATLAILMNVFERDEQPKAIGIWAGGVGIAIAIGPITGGLLLDHFWWGSVFLVNVPIVIIAVVLMLALVPDSRDPKPGRIDLVGVALSVVGLVLLVYGIIKGGQLADFTDPAVLLTIAAGLVVLVGFVLYEKRSDHPSIDITYFKNKVFSAAIAAIALVFFALMGVTFFSVFYTQSVRGYSPLQTGLLMLPLAAAQLIFAPRARLVVDRFGVRATTTGGLVILAAMLAAFAILDADTPIWILEVIFFLMGMGMAHVMTPTSVVIMQALPREKAGSASALSNTFRQVGGALGIAVLGSVLSTAYRSGIEDKLGLLPAGLRHTAGESIEATIGVAAKLGPRGDALVGAANDSFLHAMHVTAMCGAGIALVSAVVTILFLPGRPPRTPAEESTEETVGAGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-05-25" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K0R1</accession>
    <name>A0A2M9K0R1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Cold-shock protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CG723_06645</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CB01635</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000002">
        <property type="protein sequence ID" value="PJN12696.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_042152846.1">
        <property type="nucleotide sequence ID" value="NZ_NNBL01000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN12696">
        <property type="protein sequence ID" value="PJN12696"/>
        <property type="gene ID" value="CG723_06645"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04458">
        <property type="entry name" value="CSP_CDS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012156">
        <property type="entry name" value="Cold_shock_CspA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011129">
        <property type="entry name" value="CSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019844">
        <property type="entry name" value="CSD_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002059">
        <property type="entry name" value="CSP_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00313">
        <property type="entry name" value="CSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002599">
        <property type="entry name" value="Cold_shock_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00050">
        <property type="entry name" value="COLDSHOCK"/>
    </dbReference>
    <dbReference type="SMART" id="SM00357">
        <property type="entry name" value="CSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00352">
        <property type="entry name" value="CSD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51857">
        <property type="entry name" value="CSD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CSD" evidence="3">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU000408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PJN12696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="67" mass="7251" checksum="74F0327B6210A438" modified="2018-04-25" version="1">MATGTVKWFNSEKGFGFIEQDGGGADVFAHYSNIATQGFRELQEGQKVTFDVTQGQKGPQAENILPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-09-29" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K0S1</accession>
    <name>A0A2M9K0S1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Sheath polysaccharide-degrading enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_06900</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000002">
        <property type="protein sequence ID" value="PJN12735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN12735">
        <property type="protein sequence ID" value="PJN12735"/>
        <property type="gene ID" value="CG723_06900"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039448">
        <property type="entry name" value="Beta_helix"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006626">
        <property type="entry name" value="PbH1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13229">
        <property type="entry name" value="Beta_helix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00710">
        <property type="entry name" value="PbH1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="SSF51126"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014754222" evidence="1">
        <location>
            <begin position="32"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="domain" description="Beta_helix" evidence="2">
        <location>
            <begin position="95"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN12735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="321" mass="32183" checksum="7FDE40CF10CA8C29" modified="2018-04-25" version="1">MRIRSALLPALTTAALVAGGATALATPAAGAAQVIEVSTAAQLKSALTAAAPGDTIHLADGTYTGNFKTSIAGSSGSRITLTGSAKAVLTAGGGYGLHLNGASYWTVQGITVTGGQKGIMIDSAKGVVVDTVTVHGLDMEGVHFRNSSTDGTIKNSRIYDTGNDGRGMGEGVYVGTAGGTSDKSDRIQITGNTIGPDVGGENVDIKEGTTGARIVGNTFDGSGLTGANFDDSWVDVKGNDVLVENNKGSATTNTGYETHTQQSGWGCGTVFRSNTSDLRGATGDKQLAINVTNAGGSCVTTVYSSNTVTGGKGLTNVPVTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K0T3</accession>
    <name>A0A2M9K0T3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CG723_06560</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000002">
        <property type="protein sequence ID" value="PJN12680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN12680">
        <property type="protein sequence ID" value="PJN12680"/>
        <property type="gene ID" value="CG723_06560"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PJN12680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="73" mass="8064" checksum="E5E532E1A9DA61AA" modified="2018-04-25" version="1">MVATGLWAEFLPDESRREVAAAPGALPAPELDALAREVDKQDLWDLVLPLVELMDDAGKERILELPALREQAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K168</accession>
    <name>A0A2M9K168_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">IclR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CG723_07600</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000002">
        <property type="protein sequence ID" value="PJN12868.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN12868">
        <property type="protein sequence ID" value="PJN12868"/>
        <property type="gene ID" value="CG723_07600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014757">
        <property type="entry name" value="Tscrpt_reg_IclR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005471">
        <property type="entry name" value="Tscrpt_reg_IclR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09339">
        <property type="entry name" value="HTH_IclR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01614">
        <property type="entry name" value="IclR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00346">
        <property type="entry name" value="HTH_ICLR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51077">
        <property type="entry name" value="HTH_ICLR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51078">
        <property type="entry name" value="ICLR_ED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH iclR-type" evidence="3">
        <location>
            <begin position="12"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="domain" description="IclR-ED" evidence="4">
        <location>
            <begin position="75"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PJN12868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="257" mass="28246" checksum="B37E7773B790D852" modified="2018-04-25" version="1">MSAGETGGGAQVKSAVRTVELLEYFAGRPGMHSLAAVQEAVGYPKSSLYMLLRTLVELGWVETDATGTRYGIGVRALLVGTSYIDGDEVVAAARPTLDRLSDDTTETIHLARLDGTNVVYLATRQSQHYLRPFTRVGRRLPAHSTSLGKALLATHTDEQVRKMLPETLPALTEHTITDREKLIEELHTVREQGIAVDREENTLGLRCFGVAIPYRTPARDAISCSVPVARLTPAHEQMVKDALFDARDRLTLATRRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K1J6</accession>
    <name>A0A2M9K1J6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_05450</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000002">
        <property type="protein sequence ID" value="PJN12988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN12988">
        <property type="protein sequence ID" value="PJN12988"/>
        <property type="gene ID" value="CG723_05450"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="42"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN12988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="63" mass="6946" checksum="D6A8707EEBECBDBA" modified="2018-04-25" version="1">MAGPVPFRAELERTLGVDPYGHGSLPIGRWADRREATVRGVIVRYYVSGSILVVTVVRLIPEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-09-29" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K1L6</accession>
    <name>A0A2M9K1L6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CG723_07105</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CB01635</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000002">
        <property type="protein sequence ID" value="PJN13021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN13021">
        <property type="protein sequence ID" value="PJN13021"/>
        <property type="gene ID" value="CG723_07105"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="26"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="64"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="93"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="119"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="152"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="190"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="247"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="274"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="306"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="337"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="369"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="398"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="26"/>
            <end position="421"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PJN13021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="424" mass="41801" checksum="8884DD03867AA927" modified="2018-04-25" version="1">MPDSAARRRPSVPQTPQDLAGLRRRVTAVLVASQILGGLGVATGIALAAVLAKQVSGDEALSGLAPTATVAGTALLSVPLAALMTVRGRRPGLVLAYLIGALGAGVVVLAAAVGSFPLLLIGMAGFGAASSANLQARFAAADLAEPQHRARAISNVVWATTIGAVLGPNIAAPAGRSVAGLGIPAAAGPFLWAAGVFLVSAVMVQLLLRPDPLLTARALDPEEEKSAGGRSIRAGFAAVAASPRARLALVTVAVSHTAMVSIMSMTPVDLGHHGASIDLIGLVISGHIAGMYAFSPVMGRLSDRLGRLSVIGLAVGLLACAALLAGTAGGSHGQTAAGLFVLGLGWSAGLVSGSALLTDSVPQAARAAAQGLSDLTMNTAAGVGGAAAGLVVATASYAWLNLAAACLLLPLAALALFSRRPSTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K1T4</accession>
    <name>A0A2M9K1T4_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Glutamine synthetase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">glnA</name>
        <name evidence="6" type="ORF">CG723_05435</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CB01635</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the glutamine synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000002">
        <property type="protein sequence ID" value="PJN12987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN12987">
        <property type="protein sequence ID" value="PJN12987"/>
        <property type="gene ID" value="CG723_05435"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004356">
        <property type="term" value="F:glutamate-ammonia ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006542">
        <property type="term" value="P:glutamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008147">
        <property type="entry name" value="Gln_synt_b-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036651">
        <property type="entry name" value="Gln_synt_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014746">
        <property type="entry name" value="Gln_synth/guanido_kin_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008146">
        <property type="entry name" value="Gln_synth_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027303">
        <property type="entry name" value="Gln_synth_gly_rich_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004809">
        <property type="entry name" value="Gln_synth_I"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00120">
        <property type="entry name" value="Gln-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03951">
        <property type="entry name" value="Gln-synt_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01230">
        <property type="entry name" value="Gln-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54368">
        <property type="entry name" value="SSF54368"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55931">
        <property type="entry name" value="SSF55931"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00653">
        <property type="entry name" value="GlnA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00181">
        <property type="entry name" value="GLNA_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0436">Ligase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gln-synt_C" evidence="5">
        <location>
            <begin position="104"/>
            <end position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM01230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PJN12987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="453" mass="50461" checksum="4F14AE60E4C2F057" modified="2018-04-25" version="1">MDKQQEFVLRTLEERDIRFVRLWFTDVLGFLKSVAVAPAELEQAFDEGIGFDGSAIEGFARVYESDMIAKPDPSTFQVLPWRAEAPGTARMFCDILMPDGSPSFADPRYVLKRALAKTSDLGFTFYTHPEIEFFLLKNKPLDGSRPTPADNSGYFDHTPQNVGMDFRRQAITMLESMGISVEFSHHEGAPGQQEIDLRYADALSTADNIMTFRLVMKQVALEQGVQATFMPKPFSDHPGSGMHTHLSLFEGDRNAFYESGSEYQLSKVGRSFIAGLLKHAAEISAVTNQWVNSYKRIWGGGGRTAGAGGEAPSYICWGHNNRSALIRVPMYKPGKTGSARVEVRSIDSGANPYLTYAVLLAAGLKGIEEGYELPPGADDDVWALSDAERRAMGIEPLPQNLGEAIALMERSELVAETLGEHVYDFFLRNKKQEWEEYRSEVTAFELRKNLPVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K207</accession>
    <name>A0A2M9K207_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Bilirubin oxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CG723_00835</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000001">
        <property type="protein sequence ID" value="PJN13172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN13172">
        <property type="protein sequence ID" value="PJN13172"/>
        <property type="gene ID" value="CG723_00835"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011706">
        <property type="entry name" value="Cu-oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045087">
        <property type="entry name" value="Cu-oxidase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011707">
        <property type="entry name" value="Cu-oxidase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002355">
        <property type="entry name" value="Cu_oxidase_Cu_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709">
        <property type="entry name" value="PTHR11709"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07731">
        <property type="entry name" value="Cu-oxidase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07732">
        <property type="entry name" value="Cu-oxidase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="SSF49503"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00080">
        <property type="entry name" value="MULTICOPPER_OXIDASE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014786656" evidence="3">
        <location>
            <begin position="39"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="5">
        <location>
            <begin position="78"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="4">
        <location>
            <begin position="375"/>
            <end position="484"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF07731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF07732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PJN13172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="485" mass="52734" checksum="7FE28EF4213FD699" modified="2018-04-25" version="1">MLTRRHAIRLGLTTGAVGAVGAAGGLFQTLTSGGSANAATAAGAPAVTPFAVPLPVPKVLAPYRRTSTADYYAVTMSRTSHEILPGTRTDVLTYNGTFPGPTIRARKGRTAVVRQINALDMPTSVHLHGGSNPVEHDGGMTDTIAPGRSRTYVYANDQVGATLWTHDHAHHMESEHVYRGLSGLYLLGDKAEDALGLPSGRYEVPLILRDAQFDAAGQMVYTMDDAEHRTTILVNGAPWPYMRVEARKYRFRMLNSCNLRIFILCLNDGSQVTQIGSDGGLLPAPAATPVLVLSPGERVDFVVDFSKYAPGTQLTLQNMLGPGPTELVGQIMRFDVGEKAPDTSRVPDVLTTLPALPKPTVERSFELRMDEPGTGDKAYINGKTFDAGRIDTNIKWGDTEVWTVTNTSTTIPHNFHTHLVQFRILERDGQPVYPAEAGLKDTVLLFPGQTARLQLTFDTHKGVYPYHCHMIDHSAMGMMAQMKIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K2E9</accession>
    <name>A0A2M9K2E9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MarR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_01565</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000001">
        <property type="protein sequence ID" value="PJN13295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN13295">
        <property type="protein sequence ID" value="PJN13295"/>
        <property type="gene ID" value="CG723_01565"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000835">
        <property type="entry name" value="HTH_MarR-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12802">
        <property type="entry name" value="MarR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00598">
        <property type="entry name" value="HTHMARR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00347">
        <property type="entry name" value="HTH_MARR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50995">
        <property type="entry name" value="HTH_MARR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH marR-type" evidence="1">
        <location>
            <begin position="5"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN13295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="141" mass="15534" checksum="B0BA0D29F3AE75E1" modified="2018-04-25" version="1">MRALHADTGYLLYRLGLHSGRLFNATLEEFGLRLRHYALLRYLATVEGALQRELSDRLGYDPSAIVSLVDDLQDLGLVERGPAPGDRRSRIVALTDRGKGVLRDTDKGSRRVTDELLAPLAPGERATLQALLARVAEADRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K2I3</accession>
    <name>A0A2M9K2I3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_01205</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000001">
        <property type="protein sequence ID" value="PJN13237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN13237">
        <property type="protein sequence ID" value="PJN13237"/>
        <property type="gene ID" value="CG723_01205"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="67"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN13237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="118" mass="12229" checksum="9624B64C84C50729" modified="2018-04-25" version="1">MTDHQPGAPVPPLTALPDGEAQLAVVLRLTWEDLAALGQEAGRIAARTHRPVTLDEAVSHRLRTRLPAAHAKPPQATAASALSAATPRTPGDQARQAIEKINGTSTPMPPTSSGPDAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K2X8</accession>
    <name>A0A2M9K2X8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NAD-dependent deacetylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CG723_02650</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000001">
        <property type="protein sequence ID" value="PJN13482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN13482">
        <property type="protein sequence ID" value="PJN13482"/>
        <property type="gene ID" value="CG723_02650"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070403">
        <property type="term" value="F:NAD+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1600.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003000">
        <property type="entry name" value="Sirtuin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026591">
        <property type="entry name" value="Sirtuin_cat_small_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026590">
        <property type="entry name" value="Ssirtuin_cat_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02146">
        <property type="entry name" value="SIR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="SSF52467"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50305">
        <property type="entry name" value="SIRTUIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0520">NAD</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Deacetylase sirtuin-type" evidence="3">
        <location>
            <begin position="1"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PJN13482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="245" mass="26204" checksum="F7B296B4C0C762AE" modified="2018-04-25" version="1">MSTQPLVAILSGAGISTDSGIPDYRGPNGLWRRDPEAEKLVTYEYYMGDPEIRRRSWQMRRKNRTLAAEPNGAHRAVADLERAGVPVRVITQNVDGLHQLAGMPARKVLELHGSARSFVCTGCHARGPMEDALARVEAGEDDPPCLECGGILKSATVMFGERLDPVVLGEAVAITKACQVFVAVGSSLQVQPAAGLAGVAADHGARLVIVNAEATPYDELADEVIREPIGTALPKLLRRLGMAHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K370</accession>
    <name>A0A2M9K370_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">CoA-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_03175</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000001">
        <property type="protein sequence ID" value="PJN13576.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN13576">
        <property type="protein sequence ID" value="PJN13576"/>
        <property type="gene ID" value="CG723_03175"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043758">
        <property type="term" value="F:acetate-CoA ligase (ADP-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.261">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003781">
        <property type="entry name" value="CoA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043938">
        <property type="entry name" value="Ligase_CoA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032875">
        <property type="entry name" value="Succ_CoA_lig_flav_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016102">
        <property type="entry name" value="Succinyl-CoA_synth-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13380">
        <property type="entry name" value="CoA_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19045">
        <property type="entry name" value="Ligase_CoA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13607">
        <property type="entry name" value="Succ_CoA_lig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00881">
        <property type="entry name" value="CoA_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52210">
        <property type="entry name" value="SSF52210"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-grasp" evidence="2">
        <location>
            <begin position="30"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN13576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="713" mass="75339" checksum="842B0A477E659AB7" modified="2018-04-25" version="1">MAEDRELTVRALLESVRAEGRSALTAPEGKVIADAYGISVPGEELATDVEEAVAYAARFGGPVVMKIVSPDILHKTDAGGVIVGVEGAADVRAAFCKIVENARAYAPDARIEGVQVQELLPTGPSSQEVIVGAVTDPTFGKVVAFGLGGVLVEVLKDVTFRLAPVGADEAVSMLDSIRAAEVLRGVRGAQPVDRWALAEQIRRVSQLVTDFPEIAEVDLNPVIATPEGAVAADIRVILADGVPKQRRTYSREEILRSMRRLMQPRSVAVIGASNEQGKIGNSVMRNLIDGGFSGEIHPVNPKADDILGRKAYKSVTDVPGEVDVAVFAIPAKFVASALEEVGRKGIPNAVLIPSGFAETGEQALQDEIVAIGERYGVRLLGPNIYGYYSTWQDLCATFCTPYDVKGGVALTSQSGGIGMAILGFARTTKTGVSAIVGLGNKSDLDEDDLLTWFGEDPNTKCIAMHLEDLKDGRAFVEAARATVPKKPVVVLKAGRTSAGAKAAGSHTGALAGDDAVYDDILRQAGVIRAPGLNEMLEYARALPVLPTPKGDNVVIITGAGGSGVLLSDAIVDNGLSLMEIPEDLDAAFKAFIPPFGAAGNPIDITGGEPPSTYEATIRLGLEDPRIHSLVLGYWHTIVTPPMVFAELTARVVEEFRARGIEKPVVASLAGDVEVEEACQYLYERGVVAYPYTTEKPVAALGAKYRWARAAGLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JF74</accession>
    <name>A0A2M9JF74_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">IS5/IS1182 family transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_44205</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000046">
        <property type="protein sequence ID" value="PJN05524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN05524">
        <property type="protein sequence ID" value="PJN05524"/>
        <property type="gene ID" value="CG723_44205"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025161">
        <property type="entry name" value="Put_IS4/IS5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002559">
        <property type="entry name" value="Transposase_11"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01609">
        <property type="entry name" value="DDE_Tnp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13340">
        <property type="entry name" value="DUF4096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDE_Tnp_1" evidence="1">
        <location>
            <begin position="104"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN05524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="268" mass="30764" checksum="84495B2AE01C1CFC" modified="2018-04-25" version="1">MGIVERLVPDELWQLFQRVVPEAPSRPQGGGRRRHGDREVLAAIVFVATSGCTWQQLPTASFGPSGATAHRRFTEWTKARVWAKLHRLVLDELGSRGELDWSRCAIDSVNMRALKKGELTGPNPVDRGKYGSKIHLITEQTGLPLSIGISGANTHDSQALIPLVKGIPPIRSRRGRRRRRPHKLHADKGYDYNHLRRWLSDRGIRHRIARKGIETSQRLGRHRWTIERTMAWLAGCRRLHRRYERKADHFLAFTSIACTLICYRRLTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-05-25" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JFR9</accession>
    <name>A0A2M9JFR9_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">YceI domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_43520</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000043">
        <property type="protein sequence ID" value="PJN05682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN05682">
        <property type="protein sequence ID" value="PJN05682"/>
        <property type="gene ID" value="CG723_43520"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.128.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008969">
        <property type="entry name" value="CarboxyPept-like_regulatory"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007372">
        <property type="entry name" value="Lipid/polyisoprenoid-bd_YceI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036761">
        <property type="entry name" value="TTHA0802/YceI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04264">
        <property type="entry name" value="YceI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00867">
        <property type="entry name" value="YceI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101874">
        <property type="entry name" value="SSF101874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49464">
        <property type="entry name" value="SSF49464"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YceI" evidence="1">
        <location>
            <begin position="96"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN05682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="272" mass="28628" checksum="259B6B700CFAFFF8" modified="2018-04-25" version="1">MGLSARIRTRDGWALPHAVVTVTDMTGAQVLRAEADDEGAVHDAVTLTPGPYVVIVTAVGYAPTASTAMVTASGRADVGTVVLARQGGAELPPPGPWTIDPVHSSVGAVAQHLGISSVHGRFTEFGGRIEIAQDVEKSRVEAVIKASSIDTGNGMRDGHLKTPDFLDVETFPEITFRSTGLEPAGSDRWTVHGELTLHGVVRPVDLNLSYLGTGADPWGGTRAAFRATTELKREDFAMNYNQVVQAGISAIGTTLKVELDIQAVQGDALPQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JG44</accession>
    <name>A0A2M9JG44_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ribosome hibernation promoting factor</fullName>
            <shortName evidence="2">HPF</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">raiA</name>
        <name evidence="2" type="synonym">hpf</name>
        <name evidence="4" type="ORF">CG723_42240</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CB01635</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase; 100S ribosomes are translationally inactive and sometimes present during exponential growth.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Interacts with 100S ribosomes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the HPF/YfiA ribosome-associated protein family. Long HPF subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000039">
        <property type="protein sequence ID" value="PJN05860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN05860">
        <property type="protein sequence ID" value="PJN05860"/>
        <property type="gene ID" value="CG723_42240"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044238">
        <property type="term" value="P:primary metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00552">
        <property type="entry name" value="RaiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.505.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00839">
        <property type="entry name" value="HPF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034694">
        <property type="entry name" value="HPF_long/plastid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036567">
        <property type="entry name" value="RHF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003489">
        <property type="entry name" value="RHF/RaiA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032528">
        <property type="entry name" value="Ribosom_S30AE_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038416">
        <property type="entry name" value="Ribosom_S30AE_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16321">
        <property type="entry name" value="Ribosom_S30AE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02482">
        <property type="entry name" value="Ribosomal_S30AE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69754">
        <property type="entry name" value="SSF69754"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00741">
        <property type="entry name" value="yfiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0810">Translation regulation</keyword>
    <feature type="domain" description="Ribosom_S30AE_C" evidence="3">
        <location>
            <begin position="164"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF16321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PJN05860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="240" mass="26249" checksum="882C59F763EA60FD" modified="2018-04-25" version="1">MERGDPGTEFCVDIVVKGRKTEVPERFRKHVAEKLKLDKIQKFDGKVISLDVEVSKEPNPRQADRCDRVEITLRTRGPVIRAEAAASDPYAALDLATDKLEARLRKEHSKRSTRRGSGRLTAAEVPDVVATATLNGDGSVVNNEEPGGVPTTRIGSLEVQGEGPLIVREKTHVAAPMSLDQALYEMELVGHDFYLFVDSETKEPSVVYRRHAYDYGVIHLNTDPMVTQAQSSAAGGALGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-09-29" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JGC3</accession>
    <name>A0A2M9JGC3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CG723_42095</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000038">
        <property type="protein sequence ID" value="PJN05924.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN05924">
        <property type="protein sequence ID" value="PJN05924"/>
        <property type="gene ID" value="CG723_42095"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003989">
        <property type="term" value="F:acetyl-CoA carboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004658">
        <property type="term" value="F:propionyl-CoA carboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032716">
        <property type="entry name" value="ACC_epsilon"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13822">
        <property type="entry name" value="ACC_epsilon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PJN05924.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="63" mass="7040" checksum="EFC66D7D4DFCA779" modified="2018-04-25" version="1">MSRGEAVLRVERGRADDAELAALTAVLLALHRAREKPDDELEAVVASSWWRRPGDFVPPGSWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JGE9</accession>
    <name>A0A2M9JGE9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Penicillin acylase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CG723_41680</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CB01635</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
        <text evidence="5">Binds 1 Ca(2+) ion per dimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S45 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000037">
        <property type="protein sequence ID" value="PJN05960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN05960">
        <property type="protein sequence ID" value="PJN05960"/>
        <property type="gene ID" value="CG723_41680"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016811">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017000">
        <property type="term" value="P:antibiotic biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1400.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.439.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014395">
        <property type="entry name" value="Pen/GL7ACA/AHL_acylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043147">
        <property type="entry name" value="Penicillin_amidase_A-knob"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023343">
        <property type="entry name" value="Penicillin_amidase_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043146">
        <property type="entry name" value="Penicillin_amidase_N_B-knob"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002692">
        <property type="entry name" value="S45"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34218">
        <property type="entry name" value="PTHR34218"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01804">
        <property type="entry name" value="Penicil_amidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001227">
        <property type="entry name" value="Pen_acylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="SSF56235"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0106">Calcium</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0865">Zymogen</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="666"/>
            <end position="686"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="756"/>
            <end position="778"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="4">
        <location>
            <position position="226"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="159"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="298"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="301"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="477"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR001227-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR001227-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PJN05960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="778" mass="85420" checksum="F699A12CDE1F2853" modified="2018-04-25" version="1">MNSRAVNDFEIPGLAGPVEILVDQWGVPHLYAGSQDDLFLAQGFNAARDRLFQLDLWRRRGLGLLSEVFGLRYVEHDRAARLFLYRGDMAEEWSAYGEDTEQITTAFVNGINAYVSLCRRDPAQLPPEFATLGYEPAFWEPSDVARIRSHGLQYNLRDEVDRAFTLRDHGTGVEDLRRRREPAPHHLTVPEGLDLSAIPDDVLRVYDLATVPPWPDAAALQGIDGSNNWVLAPSRTVTGRPILANDPHRAVTLPALRYIAHLAAPGIDVIGAGEPALPGLSIGHNGNIAFGFTIFPIDQEDLYVYETDPDNPRAYRYKGRWETMTRVTETIPVKDGEPVEAELWFTRHGPVIHEHPTRDAAFAVRAAWLGPGMAPYLGSTGYMRAEGPDAFLAALRRWGAPGENQVYAAPDGTVGWRPAGRVPVRPNWDGTLPVPGDGRYEWDGFLDADALPAERDPDQGWFATANQMNLPPGYPNDRDTVTYDWYAPTRHHRIAEELDARTDWTVEDCVRLQTDAVSLPARRILPLLADLAGDDELTAWAIGLLRHWDADVTADSAAAALFEIWYRRHLRPAVFGKALQQVAPDAERAAALARILPPDDPTSDPRVDLDLLTGAETTLDPGTLLATLTAAVADLSALLGPDPAAWTWGALHHARVFHPVTALHEGPQPPWASVGPAPRGGSGDTVGVAPYGPDFRQTTGATFRLVVDVGSWDDSVAMNSPGQSGNPDSEHYSDLFATWAADSSFPLLYTRGQVEKHTTRTITLRPPAPATTQDPNGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JGG3</accession>
    <name>A0A2M9JGG3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">TetR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CG723_41760</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000037">
        <property type="protein sequence ID" value="PJN05976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN05976">
        <property type="protein sequence ID" value="PJN05976"/>
        <property type="gene ID" value="CG723_41760"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023772">
        <property type="entry name" value="DNA-bd_HTH_TetR-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01081">
        <property type="entry name" value="HTH_TETR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="3">
        <location>
            <begin position="14"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="37"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="194"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="207"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PJN05976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="226" mass="24794" checksum="062715C0A17D8D9F" modified="2018-04-25" version="1">MSPRSASVNEELRRRSRERLLQATVELVGERGYDATTLGDIADRAGSARGLVSYYFPGKRQLLQSAVHRLMHRTLEAALEREPHTEDGPERLARAVDAILGLAVDHPVLMRTHMAGILQAEGFVQCPEQQRLAELLRDTVLRTGSLSVDRDYPLLRSQLMGAVFAALVPGAPMPLPTLRAELFARYGLAWELGTPPDDAAPGGRSPESAPNFSQYFEPGRPGSQSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JHQ2</accession>
    <name>A0A2M9JHQ2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CG723_39585</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000031">
        <property type="protein sequence ID" value="PJN06404.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN06404">
        <property type="protein sequence ID" value="PJN06404"/>
        <property type="gene ID" value="CG723_39585"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PJN06404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="138" mass="15506" checksum="93CF459FF9B2B96E" modified="2018-04-25" version="1">MTEGRDWHWDKEAGAAEASAFMNVAVPKGATQSKGAVRINPQEDIYLLSFVTSEKNAESIAEDLHSEEPLKDKTKDFAPEGERFGHLGLTEPQTLKGARWTGVCPPCVKDDRRKKVQWIDLYVQTLNAEQARVYLQAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JHX2</accession>
    <name>A0A2M9JHX2_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 11">Aspartyl/glutamyl-tRNA(Asn/Gln) amidotransferase subunit B</fullName>
            <shortName evidence="11">Asp/Glu-ADT subunit B</shortName>
            <ecNumber evidence="11">6.3.5.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">gatB</name>
        <name evidence="13" type="ORF">CG723_38680</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">CB01635</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10 11">Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>ATP + H2O + L-aspartyl-tRNA(Asn) + L-glutamine = ADP + 2 H(+) + L-asparaginyl-tRNA(Asn) + L-glutamate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:14513"/>
            <dbReference type="Rhea" id="RHEA-COMP:9674"/>
            <dbReference type="Rhea" id="RHEA-COMP:9677"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:78515"/>
            <dbReference type="ChEBI" id="CHEBI:78516"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 11">
            <text>ATP + H2O + L-glutamine + L-glutamyl-tRNA(Gln) = ADP + H(+) + L-glutamate + L-glutaminyl-tRNA(Gln) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:17521"/>
            <dbReference type="Rhea" id="RHEA-COMP:9681"/>
            <dbReference type="Rhea" id="RHEA-COMP:9684"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:78520"/>
            <dbReference type="ChEBI" id="CHEBI:78521"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="4 11">Heterotrimer of A, B and C subunits.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the GatB/GatE family. GatB subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.-" evidence="11"/>
    <dbReference type="EMBL" id="NNBL01000029">
        <property type="protein sequence ID" value="PJN06474.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN06474">
        <property type="protein sequence ID" value="PJN06474"/>
        <property type="gene ID" value="CG723_38680"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050566">
        <property type="term" value="F:asparaginyl-tRNA synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050567">
        <property type="term" value="F:glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00121">
        <property type="entry name" value="GatB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004413">
        <property type="entry name" value="Apn/Gln-ADT_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017959">
        <property type="entry name" value="Asn/Gln-tRNA_amidoTrfase_suB/E"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006075">
        <property type="entry name" value="Asn/Gln-tRNA_Trfase_suB/E_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018027">
        <property type="entry name" value="Asn/Gln_amidotransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003789">
        <property type="entry name" value="Asn/Gln_tRNA_amidoTrase-B-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023168">
        <property type="entry name" value="GatB_Yqey_C_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017958">
        <property type="entry name" value="Gln-tRNA_amidoTrfase_suB_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014746">
        <property type="entry name" value="Gln_synth/guanido_kin_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11659">
        <property type="entry name" value="PTHR11659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02934">
        <property type="entry name" value="GatB_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02637">
        <property type="entry name" value="GatB_Yqey"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00845">
        <property type="entry name" value="GatB_Yqey"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55931">
        <property type="entry name" value="SSF55931"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89095">
        <property type="entry name" value="SSF89095"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00133">
        <property type="entry name" value="gatB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01234">
        <property type="entry name" value="GATB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 11" id="KW-0436">Ligase</keyword>
    <keyword evidence="7 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9 11" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GatB_Yqey" evidence="12">
        <location>
            <begin position="351"/>
            <end position="498"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00000924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00016923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00024799"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PJN06474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="503" mass="54230" checksum="ADB19125395950A8" modified="2018-04-25" version="1">MTVTELLSYDAALATYDPVMGLEVHVELGTKTKMFCGCSTELGAEPNSQTCPTCLGLPGALPVVNEIGIESAIKIGLALNCEIADWCRFARKNYFYPDMPKNFQTSQYDEPIAFNGYLDVQLEDGEIFRVEIERAHMEEDTGKSLHVGGATGRIHGASHSLLDYNRAGIPLIEIVTKPIEGAGERAPEVAKAYVAELREVIKALDVSEARMDKGQMRCDVNLSLRTSPEAAFGTRSETKNVNSLRSVERAARYEIQRHAAVLSSGGTIVQETRHFHEEDGSTTSGRIKDNAEDYRYFPEPDLVPVAPARAWVEELRSELPEMPRVRRNRLREEWGVSEHDMQSILNAGAVDPIVATIEAGADSVSARKWWMGELARNANESGTALDELPITPAQVARVAALVSAGDLNDKLARQVIEGVLAGEGDPDTVVEKRGLKVVSDEGALGAAVDEAIAGNAGIADKIRGGKVAAVGALVGAVMKATRGQADAARVKELILEKLGVSEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JIA4</accession>
    <name>A0A2M9JIA4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MarR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_38515</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000028">
        <property type="protein sequence ID" value="PJN06594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN06594">
        <property type="protein sequence ID" value="PJN06594"/>
        <property type="gene ID" value="CG723_38515"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000835">
        <property type="entry name" value="HTH_MarR-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023187">
        <property type="entry name" value="Tscrpt_reg_MarR-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01047">
        <property type="entry name" value="MarR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00598">
        <property type="entry name" value="HTHMARR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00347">
        <property type="entry name" value="HTH_MARR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01117">
        <property type="entry name" value="HTH_MARR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50995">
        <property type="entry name" value="HTH_MARR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH marR-type" evidence="1">
        <location>
            <begin position="8"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN06594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="166" mass="17815" checksum="3A4845336BBC8D1A" modified="2018-04-25" version="1">MDMTTAGDTGLLETLQHEVAVFARRAEQTRLGGVGQVRNSMDRAAYLLLNRLDKEGPMGVKALAASMGIDSSTVTRQVAPLVDTGLVKRTSHPEDGRAVVLQLSPRGLARLDEVRTSRQSLMAELTQEWTPQEREQFCALLTRFNTALSARQAGGPAPSGEAAPGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-05-25" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JIF0</accession>
    <name>A0A2M9JIF0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Alcohol dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CG723_37915</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CB01635</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000027">
        <property type="protein sequence ID" value="PJN06661.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN06661">
        <property type="protein sequence ID" value="PJN06661"/>
        <property type="gene ID" value="CG723_37915"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="PKS_ER"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="PKS_ER" evidence="3">
        <location>
            <begin position="11"/>
            <end position="358"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PJN06661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="360" mass="36750" checksum="D379FDA3BE9E8CDE" modified="2018-04-25" version="1">MVRAAVLPAVGSPLEITEIDLPEPGPGQVRVRLTAAGVCHSDLSLTNGTMRVPVPAVLGHEGAGTVVSVGEGVTHVAPGDGVVLNWAPACGKCHACSLGEVWLCADALTGAGSVYAHRSDDGSDLHPGLNVAAFAEETVVAANCVLRAPEGVPLTDAALLGCAVLTGYGAVHHSARVREGETVAVFGVGGVGLATLQAARIAGASKIIAVDVSPEKEELARKAGATDYVVASETTAREIRGLTGKQGVDVAVECVGRAVTIRTAWESTRRGGRTTVVGIGGKDQQVTFNALELFHFGRTLSGCVYGNSDPAKDLPVLAEHIRAGRLDLSALVTEHIALDGIPAAFDNMVAGKGGRALVVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JIL5</accession>
    <name>A0A2M9JIL5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Redoxin domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CG723_37210</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000026">
        <property type="protein sequence ID" value="PJN06725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN06725">
        <property type="protein sequence ID" value="PJN06725"/>
        <property type="gene ID" value="CG723_37210"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017004">
        <property type="term" value="P:cytochrome complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013740">
        <property type="entry name" value="Redoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017937">
        <property type="entry name" value="Thioredoxin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08534">
        <property type="entry name" value="Redoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00194">
        <property type="entry name" value="THIOREDOXIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0201">Cytochrome c-type biogenesis</keyword>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014618164" evidence="5">
        <location>
            <begin position="28"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="6">
        <location>
            <begin position="60"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="37"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="37"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PJN06725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="206" mass="22021" checksum="4B40C59C6390D0D7" modified="2018-04-25" version="1">MSADCRVSPLAASKRRTALLAAGAAVAALTLSACSSGGTSGGGNNTNFVTNSGGVSTVDQGDRHDAPKLDGKDLEGKPLDLADYKGKVIVLNVWGSWCPPCRAEANYFAKVANETKGKDVQFIGINTRDPQTEPALQFEKDHNIPYPSFYDPSGKLMLRFEKGTLNPQSIPSTLVIDRDGKIAARSLRALSEDKLRKMVDPVIAEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JIZ1</accession>
    <name>A0A2M9JIZ1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_36725</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000025">
        <property type="protein sequence ID" value="PJN06831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN06831">
        <property type="protein sequence ID" value="PJN06831"/>
        <property type="gene ID" value="CG723_36725"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014780117" evidence="2">
        <location>
            <begin position="24"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="24"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="25"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="48"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN06831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="162" mass="16010" checksum="86AFE227AC05356C" modified="2018-04-25" version="1">MGMKTKVALGAVVGIVVIGVVSANSGDGDNGNGGNGGGTSAAADKNAGDKAGKADDAAKSDAGDKGASKASQAEQFKAFVAKNGTPKEKAAVAHVLKVQGADQQNDILDSADVYTDFTGGLTGEGSGPSKLIASAFADWKDSKNGLVTVYDADGEIITNGNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-09-29" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JJ22</accession>
    <name>A0A2M9JJ22_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Cytosine permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CG723_36890</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CB01635</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the purine-cytosine permease (2.A.39) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000025">
        <property type="protein sequence ID" value="PJN06860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN06860">
        <property type="protein sequence ID" value="PJN06860"/>
        <property type="gene ID" value="CG723_36890"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001248">
        <property type="entry name" value="Pur-cyt_permease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026030">
        <property type="entry name" value="Pur-cyt_permease_Fcy2/21/22"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31806">
        <property type="entry name" value="PTHR31806"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02133">
        <property type="entry name" value="Transp_cyt_pur"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002744">
        <property type="entry name" value="Pur-cyt_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="27"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="53"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="93"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="156"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="230"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="265"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="291"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="323"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="351"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="393"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="430"/>
            <end position="447"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR002744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PJN06860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="466" mass="49797" checksum="3BD49301E2D60D64" modified="2018-04-25" version="1">MAEALVERRSIDVVPDEERHGTAFSQFTLWLGANLQITAVVTGALAVVFGGDVVWSLVGLVVGNLLGGAVMALHSAQGPRLGLPQMIQSRAQFGVRGAVVPLLLVILMYVGFFASGSVLAGQAVGELTHTGDTTGIVVFALVTGAMATVGYRVIHALGRVASIVCAVAFVYLGIRLLDRVDLSALLHDAHFDAPMFLLAISLSASWQLAFGPYVADYSRYLPRTTSAKSTFWWTLSGSAIGSQWSMTFGVLVAATAGAKFLDNQVSYVVGLGGAGVIASFLYFVIALGKLTINVLNTYGGFMSMVTSVSGFRGQKVLSQGARAAYIALIMIAGTAVALVGKDSFLSSFKDFLLFLLTFFTPWSAINLVDYYLISKERYDIPALSDPHGRYGAWRWDALTVYAVGLLAQLPFLATHFYTGPLVEPLGGADVSWIVGLVVPAVLYWAVARRNTAHIPERTLREPVVAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JJZ5</accession>
    <name>A0A2M9JJZ5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_34945</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ROK (NagC/XylR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000022">
        <property type="protein sequence ID" value="PJN07191.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN07191">
        <property type="protein sequence ID" value="PJN07191"/>
        <property type="gene ID" value="CG723_34945"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000835">
        <property type="entry name" value="HTH_MarR-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000600">
        <property type="entry name" value="ROK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18964">
        <property type="entry name" value="PTHR18964"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12802">
        <property type="entry name" value="MarR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00480">
        <property type="entry name" value="ROK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH marR-type" evidence="2">
        <location>
            <begin position="20"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN07191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="385" mass="40556" checksum="787C4CA284BD5178" modified="2018-04-25" version="1">MGRLTGGDPSLLRRINSAVVLHALRATDLATLTEITRVTGLSRPTVEGVVEGLIAAGLVVETAVDDSGTRRQGRPARRFRFRAEAGHLLGLEIGPHRVAAVLSDLDGKVLGTAAKDVDETAPADERIERLRTAVADLLRRAGVARNSLRAVGVGSPGIVEADGTVRLGTALPEWTGLQLGERLRRSFKCPVLVENDANAAAVAEHWKGAATESDDIVFVLAGLSPGAGALIGGRLHRGYGGAAGEIGALHLLGREVRPETLLSTTDEPLHPLDEQAVAQVFALARQGDERAGAAVDRFLQRLVHDVAALVLALDPELVVVGGWAAGLDGVLEPLRRELARYCLRPPRVALSVLGEAAVATGALRLALDHVEEQLFAVEGTVTARR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JK75</accession>
    <name>A0A2M9JK75_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_34925</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000022">
        <property type="protein sequence ID" value="PJN07187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN07187">
        <property type="protein sequence ID" value="PJN07187"/>
        <property type="gene ID" value="CG723_34925"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="56"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="100"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="143"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="176"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="218"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN07187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="247" mass="25315" checksum="C71C22E3C0648086" modified="2018-04-25" version="1">MTMSTTAVLRSEWIKVRSVRASAGSLLAVFVVTVSINVLATAAVGQAEADNEGADLLLGAFYALNFGQIAAIAFGTTAVSSEYLNGALRVSLAAVPNRNLLYAAKMTVVGVLAVVAGQLTSFVTFLSGQAFMGSYALGLGDPGALRACVGGGLYLALMALFAAGLTVVLRSAVAVLSLLIPFILIVSFVVGDMAGSVADFLPDHAGQQVLHQDPAGTLGPWTGLAVTAAWAAATLLAGWWALRRRDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JKE0</accession>
    <name>A0A2M9JKE0_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Riboflavin biosynthesis protein RibBA</fullName>
        </recommendedName>
        <domain>
            <recommendedName>
                <fullName evidence="13">3,4-dihydroxy-2-butanone 4-phosphate synthase</fullName>
                <shortName evidence="13">DHBP synthase</shortName>
                <ecNumber evidence="13">4.1.99.12</ecNumber>
            </recommendedName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="13">GTP cyclohydrolase-2</fullName>
                <ecNumber evidence="13">3.5.4.25</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="13">GTP cyclohydrolase II</fullName>
            </alternativeName>
        </domain>
    </protein>
    <gene>
        <name evidence="13" type="primary">ribBA</name>
        <name evidence="15" type="ORF">CG723_34335</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">CB01635</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 13">Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate.</text>
    </comment>
    <comment type="function">
        <text evidence="13">Catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 13">
            <text>D-ribulose 5-phosphate = (2S)-2-hydroxy-3-oxobutyl phosphate + formate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18457"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:58121"/>
            <dbReference type="ChEBI" id="CHEBI:58830"/>
            <dbReference type="EC" id="4.1.99.12"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12 13">
            <text>GTP + 4 H2O = 2,5-diamino-6-hydroxy-4-(5-phosphoribosylamino)-pyrimidine + formate + 3 H(+) + 2 phosphate</text>
            <dbReference type="Rhea" id="RHEA:23704"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58614"/>
            <dbReference type="EC" id="3.5.4.25"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="13">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="13">Binds 2 divalent metal cations per subunit. Magnesium or manganese.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="13">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4 13">Cofactor biosynthesis; riboflavin biosynthesis; 2-hydroxy-3-oxobutyl phosphate from D-ribulose 5-phosphate: step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 13">Cofactor biosynthesis; riboflavin biosynthesis; 5-amino-6-(D-ribitylamino)uracil from GTP: step 1/4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="13">In the C-terminal section; belongs to the GTP cyclohydrolase II family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5 13">In the N-terminal section; belongs to the DHBP synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.99.12" evidence="13"/>
    <dbReference type="EC" id="3.5.4.25" evidence="13"/>
    <dbReference type="EMBL" id="NNBL01000021">
        <property type="protein sequence ID" value="PJN07332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN07332">
        <property type="protein sequence ID" value="PJN07332"/>
        <property type="gene ID" value="CG723_34335"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00275">
        <property type="reaction ID" value="UER00399"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008686">
        <property type="term" value="F:3,4-dihydroxy-2-butanone-4-phosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003935">
        <property type="term" value="F:GTP cyclohydrolase II activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009231">
        <property type="term" value="P:riboflavin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00641">
        <property type="entry name" value="GTP_cyclohydro2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10990">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00179">
        <property type="entry name" value="RibA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00180">
        <property type="entry name" value="RibB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01283">
        <property type="entry name" value="RibBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017945">
        <property type="entry name" value="DHBP_synth_RibB-like_a/b_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000422">
        <property type="entry name" value="DHBP_synthase_RibB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032677">
        <property type="entry name" value="GTP_cyclohydro_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000926">
        <property type="entry name" value="RibA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036144">
        <property type="entry name" value="RibA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016299">
        <property type="entry name" value="Riboflavin_synth_RibBA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00926">
        <property type="entry name" value="DHBP_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00925">
        <property type="entry name" value="GTP_cyclohydro2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF142695">
        <property type="entry name" value="SSF142695"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55821">
        <property type="entry name" value="SSF55821"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00505">
        <property type="entry name" value="ribA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00506">
        <property type="entry name" value="ribB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 13" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="9 13 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11 13 15" id="KW-0456">Lyase</keyword>
    <keyword evidence="13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="13" id="KW-0464">Manganese</keyword>
    <keyword evidence="7 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="8 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 13" id="KW-0686">Riboflavin biosynthesis</keyword>
    <keyword evidence="13" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="GTP_cyclohydro2" evidence="14">
        <location>
            <begin position="228"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="region of interest" description="DHBP synthase" evidence="13">
        <location>
            <begin position="1"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="region of interest" description="D-ribulose 5-phosphate binding" evidence="13">
        <location>
            <begin position="45"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="D-ribulose 5-phosphate binding" evidence="13">
        <location>
            <begin position="160"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="GTP cyclohydrolase II" evidence="13">
        <location>
            <begin position="222"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor; for GTP cyclohydrolase activity" evidence="13">
        <location>
            <position position="350"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile; for GTP cyclohydrolase activity" evidence="13">
        <location>
            <position position="352"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="46"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="50"/>
        </location>
        <ligand>
            <name>D-ribulose 5-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58121"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="163"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="184"/>
        </location>
        <ligand>
            <name>D-ribulose 5-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58121"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="272"/>
            <end position="276"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="277"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="288"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="290"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="293"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="316"/>
            <end position="318"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="338"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="373"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="378"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="site" description="Essential for DHBP synthase activity" evidence="13">
        <location>
            <position position="146"/>
        </location>
    </feature>
    <feature type="site" description="Essential for DHBP synthase activity" evidence="13">
        <location>
            <position position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00005520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00029293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="PJN07332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="432" mass="47013" checksum="7DA360E1FC526075" modified="2018-04-25" version="1">MTTAPVWYSTSRDEDNSDLSLDPVEQAIRDIANGRPVVVVDDEDRENEGDLVIAAEKATPEIVAFMMSECRGLICAPMESDELERLQLPQMVENNTESMRTAFTVSVDAGPAHGVTTGISAADRATTLQLLAGGTAEAGDFVRPGHIFPLRAKAGGVLVRNGHTEAAVDLARLAGLRPAGAIVEIAGEDGTMLRLPELIPFARKHGLTIISIEDLIAYRRSSEPTVRREAEVNLPTAFGDFTAYGYRSTVDGVEHVALVHGEIGDGQDVLVRVHSECLTGDVFHSLRCDCGPQLEESMRRITEEGRGIVVYLRGHEGRGIGLLSKLRAYELQERGRDTLDANLELGLPADSRDYAAGAQILEDLGVRGLRLLTNNPDKTDALLRHGLKVVARESMPVQAGEHNLRYLRTKRDRMGHDLPWLDAPTSTTCANQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JKE2</accession>
    <name>A0A2M9JKE2_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Peptidase_C39_2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CG723_34380</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000021">
        <property type="protein sequence ID" value="PJN07341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN07341">
        <property type="protein sequence ID" value="PJN07341"/>
        <property type="gene ID" value="CG723_34380"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02549">
        <property type="entry name" value="Peptidase_C39A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039564">
        <property type="entry name" value="Peptidase_C39-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039563">
        <property type="entry name" value="Peptidase_C39_single_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13529">
        <property type="entry name" value="Peptidase_C39_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014955082" description="Peptidase_C39_2 domain-containing protein" evidence="2">
        <location>
            <begin position="35"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_C39_2" evidence="3">
        <location>
            <begin position="241"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="58"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PJN07341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="455" mass="48949" checksum="8AD6186F1C53402F" modified="2018-04-25" version="1">MTRPEPLSRRTLLAAAAATAGAAALATTAGTAVAGTGAPARAHAAPRLVDNHAWTSHSDWRSGTAAGTRAVAGSRPGLTLATPEGRTDYTDPHTGKTATWEYGRWTSPAHRLSVPATEVIASWNARTPAGTWIQIELQGTYSDGAATPWYVMGRWAAGDQDIRRTSVDDQSDGKSSIWTDTFAIDDAASGLRLVSYRLRLTLYRAPGSKASPLVWRLGAMGSDVPDRFSVPASKPGLAKELSVPRYSQSIHAGQYPEYDNGGEAWCSPTSSQMIVEYWGREPSSDDLSWVNPDYTDPQVCHAARFTYDYQYEGCGNWPFNAAYASTYKDLQGVVTRLGSLGDLETLIAAGIPAITSQSFLKEELTGAGYGTSGHLMTVIGFTADGDVIANDPASPSDTAVRRVYKRAEWEKIWLRTKRYNASGSVVSGTGGVCYLYFPAHPTPKQRRALEAVGVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-05-25" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JKJ2</accession>
    <name>A0A2M9JKJ2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Diguanylate cyclase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CG723_34640</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000021">
        <property type="protein sequence ID" value="PJN07389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN07389">
        <property type="protein sequence ID" value="PJN07389"/>
        <property type="gene ID" value="CG723_34640"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd01948">
        <property type="entry name" value="EAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01949">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001633">
        <property type="entry name" value="EAL_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035919">
        <property type="entry name" value="EAL_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000160">
        <property type="entry name" value="GGDEF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00563">
        <property type="entry name" value="EAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00990">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00052">
        <property type="entry name" value="EAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00267">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141868">
        <property type="entry name" value="SSF141868"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="SSF54631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="SSF55073"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00254">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50883">
        <property type="entry name" value="EAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50887">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0129">CBS domain</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EAL" evidence="3">
        <location>
            <begin position="1"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="5">
        <location>
            <begin position="306"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="domain" description="GGDEF" evidence="4">
        <location>
            <begin position="397"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="531"/>
            <end position="562"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PJN07389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="562" mass="58249" checksum="17C2E16C4140B4A0" modified="2018-04-25" version="1">MPSWTDALRFAFQPVVNLTTGAVAALEILARPEVGDVLAQARRDPELDGRLAALAVRSAAQRETLLPLHVNVFAGTVADLGGLAALRDAVRDVGRLPWEVTVDIGPPFTHVPHRALLEGVTTLREEGFRICADGVGDGDLPLRLLFDLAPGLVKLDASLLSRRASVSAMRTLCEGLGALLAVEGVETELQCGAAREAGAQLAQGELFAPPSRLPAADVYVPALTPPVASPPPSGPPVRQFVRPAALLPASASAGRVRALLTGSPDVSGVLLVDSAGAPVRSVQRDRFLLSLSGRYGHALYADRPAARHGDRPRTVGVDATAWEVLDVLADGERSRTADDVAVVDKRGRCVGIVRLADLVRALAESRVEEAAALNPLTRLPGSDAITGEVDRRIAQGRGFALSWLDIDGFKQVNDGAGFAAGDDLIREVGRSLERAASGATRVGHIGGDDFLVLADPDALDPLASAVLDVPWAAGGRPVTMSLATVLCAAGSVADHRQAAASLAPLKQAAKALPGASWVIGRSDTQGHEVRRGMRSGAAPVSGAAWAGTGPRAEAESGRAATG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JKK0</accession>
    <name>A0A2M9JKK0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CG723_34675</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000021">
        <property type="protein sequence ID" value="PJN07395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN07395">
        <property type="protein sequence ID" value="PJN07395"/>
        <property type="gene ID" value="CG723_34675"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PJN07395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="300" mass="32345" checksum="1F882B15D2707082" modified="2018-04-25" version="1">MAHTQNTQHAGMRRVLRREVAGIIGLLADERDFTAMRSYRTFAFDDHDTYLQQVENLLQALAAQGGHTTVALFDPEEYAEFCAETGLEPDTPTSRTRFTAELAVMGTTVPYEGQPLADLLPDLVDEAVRQATWEYASSVLARIGPCGACGRDIGRDAFARASHLLTRVLDAAGTGAHHLVCSIPTGAESVLSVLHVDRCTEDSTRLDEKEALEFTTVLALGIATASPGGLVMRTTAPDTDDRVQGWRLRDERLLPLTAAEVFDAYCTDAQSGDLVAPESGVDYCAAPDLGDTGPEVGHTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JKK4</accession>
    <name>A0A2M9JKK4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Phosphoenolpyruvate--carbohydrate phosphotransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CG723_34685</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000021">
        <property type="protein sequence ID" value="PJN07396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN07396">
        <property type="protein sequence ID" value="PJN07396"/>
        <property type="gene ID" value="CG723_34685"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009401">
        <property type="term" value="P:phosphoenolpyruvate-dependent sugar phosphotransferase system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.70.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011055">
        <property type="entry name" value="Dup_hybrid_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001127">
        <property type="entry name" value="PTS_EIIA_1_perm"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00358">
        <property type="entry name" value="PTS_EIIA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51261">
        <property type="entry name" value="SSF51261"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00830">
        <property type="entry name" value="PTBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51093">
        <property type="entry name" value="PTS_EIIA_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="PTS EIIA type-1" evidence="3">
        <location>
            <begin position="20"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PJN07396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="149" mass="15305" checksum="AC7E47F4CE79C33E" modified="2018-04-25" version="1">MTSVTSPLAGRAIGLSAVPDPVFSGAMVGPGTAIDPVREPSAAVAPVDGIVVSLHPHAYVVVDDQGHGVLTHLGIDTVQLNGEGFELLVNKGDTVQRGQEMVRWDPAAVEAAGKSPICPIVALEATAESLSDVIEDGNVKSGDALFSWK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JKT2</accession>
    <name>A0A2M9JKT2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CG723_33815</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000020">
        <property type="protein sequence ID" value="PJN07473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN07473">
        <property type="protein sequence ID" value="PJN07473"/>
        <property type="gene ID" value="CG723_33815"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PJN07473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="59" mass="6093" checksum="3A4DE9E369F91C12" modified="2018-04-25" version="1">MFVSLRGAFGAKGAADGIAGDRADGAVDGLAVKSIRLGSRPLLAVREPCATFRTRYGLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JKT5</accession>
    <name>A0A2M9JKT5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Mini-circle protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CG723_33900</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000020">
        <property type="protein sequence ID" value="PJN07486.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN07486">
        <property type="protein sequence ID" value="PJN07486"/>
        <property type="gene ID" value="CG723_33900"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034660">
        <property type="entry name" value="DinB/YfiT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007061">
        <property type="entry name" value="DUF664"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04978">
        <property type="entry name" value="DUF664"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109854">
        <property type="entry name" value="SSF109854"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PJN07486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="170" mass="19075" checksum="6D95600348393E71" modified="2018-04-25" version="1">MTLPRIRPAYDADERTQLVAWLDMQRAIVEWKCEGVSEKDAHRSVLPASPAMTLAGVVSHLRWVEHCWFEVMLMGGAAEGPQFDDGPEDADMLVDDVPLDQLLGEYARQYARSNEITAAHSLDQAGRHPDFRAGAANLRWILLHMIEETARHAGHLDAIRELLDGGRGYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JLB9</accession>
    <name>A0A2M9JLB9_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Prephenate dehydratase</fullName>
            <ecNumber evidence="3">4.2.1.51</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CG723_32830</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">CB01635</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>H(+) + prephenate = 3-phenylpyruvate + CO2 + H2O</text>
            <dbReference type="Rhea" id="RHEA:21648"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:18005"/>
            <dbReference type="ChEBI" id="CHEBI:29934"/>
            <dbReference type="EC" id="4.2.1.51"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-phenylalanine biosynthesis; phenylpyruvate from prephenate: step 1/1.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.51" evidence="3"/>
    <dbReference type="EMBL" id="NNBL01000019">
        <property type="protein sequence ID" value="PJN07663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN07663">
        <property type="protein sequence ID" value="PJN07663"/>
        <property type="gene ID" value="CG723_32830"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00121">
        <property type="reaction ID" value="UER00345"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004106">
        <property type="term" value="F:chorismate mutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004664">
        <property type="term" value="F:prephenate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009094">
        <property type="term" value="P:L-phenylalanine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002912">
        <property type="entry name" value="ACT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008242">
        <property type="entry name" value="Chor_mutase/pphenate_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001086">
        <property type="entry name" value="Preph_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018528">
        <property type="entry name" value="Preph_deHydtase_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00800">
        <property type="entry name" value="PDT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001500">
        <property type="entry name" value="Chor_mut_pdt_Ppr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="SSF55021"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51671">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00857">
        <property type="entry name" value="PREPHENATE_DEHYDR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51171">
        <property type="entry name" value="PREPHENATE_DEHYDR_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0456">Lyase</keyword>
    <keyword evidence="7" id="KW-0584">Phenylalanine biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Prephenate dehydratase" evidence="10">
        <location>
            <begin position="4"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="domain" description="ACT" evidence="11">
        <location>
            <begin position="198"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="site" description="Essential for prephenate dehydratase activity" evidence="9">
        <location>
            <position position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR001500-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PJN07663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="311" mass="33460" checksum="617C8FEC54826444" modified="2018-04-25" version="1">MSASYAYLGPQGTFTEVALRTLPETATRELVPMVSVPAALDAVRNGEAEAAFVPIENSVEGGITTTLDELVAGEPLMIYREVLLSITFALLVRPGTQVSDIKTVTAHPAAQPQVRNWMKANLAEDVTWESAASNADGARLVQEGRYDAAFAGAFAAERYGLVPLVTEIHDAENAQTRFVLVGKPARPAAPTGADKTSVVIWQRDDHPGALLELLQEFAVRGVNLMLLQSRPTGEGIGNYCFAIDAEGHISDRRVGEALMGLKRVCPQVRFLGSYPRAGVTVADVRTPRTGTSDSDFMAASDWLARCQDGRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JM01</accession>
    <name>A0A2M9JM01_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Phosphoesterase PA-phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_31490</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000017">
        <property type="protein sequence ID" value="PJN07904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN07904">
        <property type="protein sequence ID" value="PJN07904"/>
        <property type="gene ID" value="CG723_31490"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036938">
        <property type="entry name" value="P_Acid_Pase_2/haloperoxi_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000326">
        <property type="entry name" value="P_Acid_Pase_2/haloperoxidase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01569">
        <property type="entry name" value="PAP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48317">
        <property type="entry name" value="SSF48317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="acidPPc" evidence="1">
        <location>
            <begin position="313"/>
            <end position="438"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN07904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="452" mass="48411" checksum="251837B9BCEAE67A" modified="2018-04-25" version="1">MPIRRWLRYRACAGRRVRPGNNTHPHVREGVSVNPIRTRRSALKALGSAALLAASGTVPSATAAVADERESRPSVVLDWYDATATTISAAGAATQITNSRTWAVSWLAAARATREVPLGVDRSDFQDAALASAVHDSLVALAPSRTQELDAALRATLDRVPDGPAKTKGAAAGAREARLVLASREGDGLDPASVNAPFTVPPAAPGVWQPTPPAYATAAQYGNRIARPFLLVGPDQYRLPAPPVLDSARYRADLAEVRAYGAMNSSVRTERQTETAIFWFGSSLTLYIEPLRVALARAPHSTAGQARLVALFHVALVETQIATSDTKYTYLRWRPVTAIHAGAIDPDPEWTPLHITPAHPDYPSGHNTYAGAAETVLTALTGSRTGPFELTSPTAPGVTRTYTAWRQLSQDNLDARVYSGIHTRSADEAGLVLGKRVAEHTLHNAERLFGVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JM45</accession>
    <name>A0A2M9JM45_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Helix-turn-helix transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_31810</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000017">
        <property type="protein sequence ID" value="PJN07943.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN07943">
        <property type="protein sequence ID" value="PJN07943"/>
        <property type="gene ID" value="CG723_31810"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH luxR-type" evidence="2">
        <location>
            <begin position="257"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00421"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN07943.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="337" mass="36655" checksum="4FE3A75B6544B3F2" modified="2018-04-25" version="1">MLEALGLSTAESQVYQLLVGSGRCPVDRLEQRTGLTGAQLEQAVAALAVKGLVALTDDLPAQLIPAPPDIAGETLLLARMNELQSAKGVLQRLTKEYREALRPAALEEIAEIVPAEALAQRCEQLQLRARREVLRFDAPPYLLIEEFNVAELEQLAAGVRFRTVYDRAAIEGYAEQLEIRRYMDAGEQARVLARLPVKLIIVDRSTAMLAVRTEDGRPPGAVVQINQGPLLDALVTLFELVWVTALPLDPSTGETHRGELSGSDTHLLLLLLSGLTDDAIARLMGIGKRTVNRRVRGLMDLTGASSRMQLGWHACEHGWVTAGDLDGLQPPGIGQDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-06-02" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JM68</accession>
    <name>A0A2M9JM68_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">DNA-binding response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CG723_30230</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000016">
        <property type="protein sequence ID" value="PJN07980.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN07980">
        <property type="protein sequence ID" value="PJN07980"/>
        <property type="gene ID" value="CG723_30230"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00383">
        <property type="entry name" value="trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="4"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="domain" description="OmpR/PhoB-type" evidence="5">
        <location>
            <begin position="123"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="3">
        <location>
            <begin position="123"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PJN07980.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="220" mass="23774" checksum="DA6A30A496720AC0" modified="2018-04-25" version="1">MRHRILVVEDDHALRDVLLRSLRDEDFDAVPAQDGATALRLAGDAVDAAVLDVGLPDADGRDVCQAIRANGFVFPVIFLTAHHRLTDRLAGFSAGGDDYLPKPFHTMELAARLRAALKRNGSSQSATCGDVLLDPVGHSLTVRGTRVALTPTEFRLLAALMAASGAIVRRRELIRAGWPEGAHVSDNTLDQYLTRLRRKLRDGGSALTVTTARGVGHRLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JMB4</accession>
    <name>A0A2M9JMB4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CG723_30445</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000016">
        <property type="protein sequence ID" value="PJN08016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08016">
        <property type="protein sequence ID" value="PJN08016"/>
        <property type="gene ID" value="CG723_30445"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004104">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02894">
        <property type="entry name" value="GFO_IDH_MocA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GFO_IDH_MocA" evidence="2">
        <location>
            <begin position="10"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="domain" description="GFO_IDH_MocA_C" evidence="3">
        <location>
            <begin position="168"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="387"/>
            <end position="409"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PJN08016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="409" mass="43201" checksum="3ED919A58EA03196" modified="2018-04-25" version="1">MTGGAPAPLGVGLVGCGGFAEFVLDAVADLPGLHLAAVADPSRERAERLGARHGVPALASLDELLERDDVAAVLIATPPATHAAMAITALGAGRHVFCEKPLATTTEDASAVAHEARLAGRVLVVDHVLRYNPLLRAVRHLTERGLLAPPRRFLFENDASDEDLGPDHWFWDPAHSGGIFVEHGVHFFDAARALLGSDPVSVRATAVARPGGPVDMVSADVVHPGGVLASHLHSFTHAHRAERQLMRLDHGFAETRISGWIPVQAKISAWTDEEGARRWEQLPDRLCELLSVDGFRPHGEERITVRVERDAGSAAPARGRGEQRTVPHHVTAVLDLGGEARKPYVYAQSVRAAMADLVRAVREDTPPVADAVSGFAAVAVAEAATLAASTGTEQGVPSPDLTVSEGASA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JML1</accession>
    <name>A0A2M9JML1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_30865</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000016">
        <property type="protein sequence ID" value="PJN08113.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08113">
        <property type="protein sequence ID" value="PJN08113"/>
        <property type="gene ID" value="CG723_30865"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014611691" evidence="1">
        <location>
            <begin position="26"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN08113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="214" mass="22729" checksum="C7481B8B4A633CFE" modified="2018-04-25" version="1">MAATVAALALGLTGAGSSPAASSAAADRPTAEIFATDNTAVITDPDDPRLHTRLTRFDHEVRGIVRANGATPVASKLLEGVFWSGDLKQATYERSREFGINRVGRDGLHHIAGVIAKTYHQESVLTFRRLPPTSPETDALEIEAAGVSASRLHDELVADPVARDKLGGGSVTVDGRLILIAPLGDLPLAREFTAKLGVDWQTAQVHYGDREFVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JMN1</accession>
    <name>A0A2M9JMN1_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ribosome-binding ATPase YchF</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4 7" type="primary">ychF</name>
        <name evidence="7" type="ORF">CG723_29430</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CB01635</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">ATPase that binds to both the 70S ribosome and the 50S ribosomal subunit in a nucleotide-independent manner.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. YchF/OLA1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000015">
        <property type="protein sequence ID" value="PJN08130.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08130">
        <property type="protein sequence ID" value="PJN08130"/>
        <property type="gene ID" value="CG723_29430"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043023">
        <property type="term" value="F:ribosomal large subunit binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04867">
        <property type="entry name" value="TGS_YchF_OLA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01900">
        <property type="entry name" value="YchF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00944">
        <property type="entry name" value="YchF_OLA1_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004396">
        <property type="entry name" value="ATPase_YchF/OLA1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031167">
        <property type="entry name" value="G_OBG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004095">
        <property type="entry name" value="TGS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012676">
        <property type="entry name" value="TGS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023192">
        <property type="entry name" value="TGS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013029">
        <property type="entry name" value="YchF_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041706">
        <property type="entry name" value="YchF_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06071">
        <property type="entry name" value="YchF-GTPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006641">
        <property type="entry name" value="CHP00092"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00326">
        <property type="entry name" value="GTP1OBG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81271">
        <property type="entry name" value="SSF81271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00092">
        <property type="entry name" value="TIGR00092"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51710">
        <property type="entry name" value="G_OBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51880">
        <property type="entry name" value="TGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0460">Magnesium</keyword>
    <keyword evidence="1 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OBG-type G" evidence="5">
        <location>
            <begin position="3"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="domain" description="TGS" evidence="6">
        <location>
            <begin position="277"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="12"/>
            <end position="17"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00944"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PJN08130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="362" mass="39272" checksum="6AC6C69BDD952943" modified="2018-04-25" version="1">MSLTIGIVGLPNVGKSTLFNALTKNDVLAANYPFATIEPNVGVVGVPDPRLAKLAEVFSSQKTLPATVDFVDIAGIVRGASEGEGLGNKFLANIRESDAICQVIRAFKDENVVHVDGKVSPKDDIETINTELILADLQSVEKQVPRLQKESRLQKEKVAVLAAVEEAQKILESGTTLFAAGITAGTEKGRLLHELHLLTTKPFLYVFNVDEDELVDEDFKNEQRALVAPAEAIFLNAKIESELIELDDDEALELLQSMGQEEPGLATLGRVGFDTLGLQTYLTAGPKETRAWTIKKGATAPEAAGVIHTDFQKGFIKAEVISFDDLMETGSVAEARAKGKARMEGKDYVMQDGDVVEFRFNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JMZ8</accession>
    <name>A0A2M9JMZ8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CG723_29940</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000015">
        <property type="protein sequence ID" value="PJN08225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08225">
        <property type="protein sequence ID" value="PJN08225"/>
        <property type="gene ID" value="CG723_29940"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015833">
        <property type="term" value="P:peptide transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013563">
        <property type="entry name" value="Oligopep_ABC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08352">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="4"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="272"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="36"/>
            <end position="43"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="308"/>
            <end position="315"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PJN08225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="525" mass="55815" checksum="A0A2B140DCE51CC0" modified="2018-04-25" version="1">MSLVEVDALTVEFGDLRAVDALSFRLEEGAALGVVGESGSGKSTVASALLGLHRGTGARVTGSVRVAGTDVQEADDETLRRLRGGTAAMVFQDPLSSLDPYYAVGDQIAEVYRVHSKASRRAARARAVEVLDRVGIPDAARRARSRPHEFSGGMRQRALIAMALACEPALLVADEPTTALDVTVQAQILDLLHGLRQETGMGLILVTHDVGVAAESVDDVLVMRHGRAVERGAVADVLGAPSAAYTKELLGAVPRVDAARPQRPDTTGDVLLEAVDLRREFGRGKRAFAAVDGVSLTVRRGETVGIVGESGSGKTTLGRMLVGLLEPTSGQVLLSGARSDTGVQMVFQDPVSSLNPRRSVGESVADPLRARGDKEVRDRVEELLERVGLDPAHYGRYPHEFSGGQRQRVGIARALAAEPRIIVCDEAVSALDVTTQAQVTGLLRELQDELGLALVFIAHDLAVVRQVSDRVAVMRKGRVVEYGAVDEVYGAPQDPYTRQLLAAVPALDPAAAARRRTARRELAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JN15</accession>
    <name>A0A2M9JN15_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CG723_30070</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000015">
        <property type="protein sequence ID" value="PJN08249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08249">
        <property type="protein sequence ID" value="PJN08249"/>
        <property type="gene ID" value="CG723_30070"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.160.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002838">
        <property type="entry name" value="AIM24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036983">
        <property type="entry name" value="AIM24_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016031">
        <property type="entry name" value="Trp_RNA-bd_attenuator-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01987">
        <property type="entry name" value="AIM24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51219">
        <property type="entry name" value="SSF51219"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PJN08249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="251" mass="27275" checksum="4C2A939495B14214" modified="2018-04-25" version="1">MQSPLFAHSEQQTQERYTVQNPQLLRVTLEGHDDILARKGAMVAYQGLVEFDGEIQTSGQRRARANTGEGLDLMRCHGQGTVYLANLAQFIHVVEVEQDGLTVDSSYVLALDSSLSYQVVAVDSQYGISGSGKYQLNITGRGKVALMTSGQPLMLQVTPDRYVNADADAIVAWSNGLRVQMQAQTHSSGVWRRRGNTGEGWELSFMGQGYALVQPSELLPPQNAVIGQGLGAQYGMGQQGARGQNQGNVWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JN32</accession>
    <name>A0A2M9JN32_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Nucleotidyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CG723_28175</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000014">
        <property type="protein sequence ID" value="PJN08282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08282">
        <property type="protein sequence ID" value="PJN08282"/>
        <property type="gene ID" value="CG723_28175"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="SSF81301"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PJN08282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="266" mass="29739" checksum="B6BD6E583F3D94E0" modified="2018-04-25" version="1">MDLTARGLDERGFIEREGSLSRIQPDFRPVVSAARDGLLAGFGPRMASAYLYGSVPRGTARLGRSDLDLLLALREEPTDDDRAEAGALAEGLNKQFAQIDGVGLLILSRSQVLSDLERHDLGWFVACLCTPLLGEDLAEYLPRYRPDSLLARETNGDLRLLLTRWRERIARGDDPRTLDRQISRHLVRTGFTLVMPRWNGWTSDLTQMAEVFGTYYPQWADAMRQASEAAYEPVGAPHTLRAYTEDLGPWLAAEYEAVHGVKAPRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JN72</accession>
    <name>A0A2M9JN72_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">tRNA 2-methylthio-N6-isopentenyl adenosine(37) hydroxylase MiaE-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CG723_29890</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000015">
        <property type="protein sequence ID" value="PJN08267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08267">
        <property type="protein sequence ID" value="PJN08267"/>
        <property type="gene ID" value="CG723_29890"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012347">
        <property type="entry name" value="Ferritin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009078">
        <property type="entry name" value="Ferritin-like_SF"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47240">
        <property type="entry name" value="SSF47240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PJN08267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="244" mass="25989" checksum="5AB732B21D0ABA56" modified="2018-04-25" version="1">METPDTAAAADEPTGIAAQDWAKASVDPHYRAAVVDLLGALAYGELAAFERLAEDAKLAPTLGDKAELAKMASAEFHHFEQLHDRLSAIGVAPTEAMEPFVAALDGFHKQTAPSDWLEGLVKAYVGDSIASDFYREVAARLDSDTRSLVLAVLDDTGHASFAVEKVRAAIEAEPRVGGRLALWARRLMGEALSQSQRVVADRDALSTMLVGGVADGFDLAEVGRMFSRITEAHTKRMAALGLAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JNB5</accession>
    <name>A0A2M9JNB5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_28630</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000014">
        <property type="protein sequence ID" value="PJN08354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08354">
        <property type="protein sequence ID" value="PJN08354"/>
        <property type="gene ID" value="CG723_28630"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="36"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="99"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="140"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="171"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="205"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="252"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="309"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="356"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="407"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="436"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="466"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="509"/>
            <end position="531"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN08354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="538" mass="55223" checksum="E5C58C8311D7FFAE" modified="2018-04-25" version="1">MTAAVADTRFVPRAAGARQLAGTGTLVRLALRRDRVMIPVWVAVILMMVLSMPGSLKSVYSTAAERADIAQSMVTNSSMRALYGPVFADSIGGLTAWRIGVYGGLFAAIMSLLIVVRHTRDEEESGRQELVSSAMVGRRAPLTAALLAALVANAATALLVAGGLASQGGGGAMALGLAIAATGMVFATMAAIVAQLTESARLAKGLTSAVLGLAFVLRAAGDSGTAEGSSALTWLSPLGWLENTRAFADERWWVLLLFVAGVAAQGVVAYGLAGRRDIGMSFLPSRPGPAEGRLGTAGALAWRLQRGTVFGWSAGFLVAGIAFGGMTQGATDLVGDNQKTRDIIERMGGQSGVTDAFLATMVGMLGMVAALYIVSSVLRLSGEETSQRAEPLLAAAVGRLRWAAGHLVIAFGGAALIMVVGGLGLGIGYGKSFGPVLGACLTQLAAIWVIGGLAVLLFGVFPRAAVAAWAVAGIALLIGWIGPAFDLPQSVMNLSPFGHLPKLPGGDMAWTPVLTLTPIAVVFVAAGLTGLRRRDLSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JNW9</accession>
    <name>A0A2M9JNW9_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Probable membrane transporter protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CG723_27795</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CB01635</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the 4-toluene sulfonate uptake permease (TSUP) (TC 2.A.102) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000013">
        <property type="protein sequence ID" value="PJN08573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08573">
        <property type="protein sequence ID" value="PJN08573"/>
        <property type="gene ID" value="CG723_27795"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002781">
        <property type="entry name" value="TM_pro_TauE-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01925">
        <property type="entry name" value="TauE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="38"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="98"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="161"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="187"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="217"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PJN08573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="236" mass="24162" checksum="4FBDD7C755806B27" modified="2018-04-25" version="1">MSTQILVVLAVTVAIAAFVQGSSGLGFALIVAPVAGILDPGLVPVFVLGSMIPLNLYVAWRERSSLDLRGAGWITGARLAATPAGLAVLWLIPERSLGLFVGGATVLAAVASLTVPAFTPGRAAYVGAGAVTGLTETATGVGGPPLALVYQHRPPAELRSTVAACFLVGEVASLALLFATGKAQVTELGQAAALLPAIAVGAWLSRLVHHRLDARRMRLFVLVFALVSGLVLMLRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JPE9</accession>
    <name>A0A2M9JPE9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_26875</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000012">
        <property type="protein sequence ID" value="PJN08715.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08715">
        <property type="protein sequence ID" value="PJN08715"/>
        <property type="gene ID" value="CG723_26875"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="28"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="160"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="192"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="221"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="306"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN08715.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="339" mass="34757" checksum="9FC4C56EAC16F572" modified="2018-04-25" version="1">MATRLGPAAEADLTTTASSSTAPPVRLWLQPAVIALVVVAAFVGCYVGLQRNPQPHRVPVAVAGQELSGEIRQVLGDSVDVHPVADAATGRAELERRDVVAAVSGRADSDRLRLEVGGANGQSTTTAVKSLIGAYAHGSSQRLTTVDVVPFARFDSRGLAGFYMAFGVTLAGFVLAQNALGLANRLHLRHRFWLLSGVSVAIGIVATVIAGPILGAVPAPVVPLAFGLTLLAAAAAFTTKLLGTYLGPVGVPVATLLLLTVGNSTSGATIGPDLLPSAARAVSALLPPGAAVRAVTDLSYFHGAQAVQPLATLALWAVIAAVLVSLRPHLRRRPARVTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-09-29" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JPJ5</accession>
    <name>A0A2M9JPJ5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Enoyl-CoA hydratase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_26385</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the enoyl-CoA hydratase/isomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000012">
        <property type="protein sequence ID" value="PJN08798.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08798">
        <property type="protein sequence ID" value="PJN08798"/>
        <property type="gene ID" value="CG723_26385"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.12.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014748">
        <property type="entry name" value="Enoyl-CoA_hydra_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN08798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="242" mass="25110" checksum="90B2B2DBE0CB7036" modified="2018-04-25" version="1">MVHASHERGITTLSLDSPSNRNALSAGLVAELADAFTACAKDDAVRAVVLTHTGNTFSAGADLKSPPPPAALVALLRQIVALDRPVVARIAGHVRAGGLGLLGACDISAASHAASFAFTEVRIGVAPAVISLPLLPRTDPRAVARYYLTGERFDAAEAVRIGLLTAAGDDVDAALAPVLDGLRRSSPQGLAETKRLLTAKVLEAFDRDAADLSALSARLFSSAQASEGMTAFLERRDPAWVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JPK5</accession>
    <name>A0A2M9JPK5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">M6 family metalloprotease domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_26910</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000012">
        <property type="protein sequence ID" value="PJN08812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08812">
        <property type="protein sequence ID" value="PJN08812"/>
        <property type="gene ID" value="CG723_26910"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008757">
        <property type="entry name" value="Peptidase_M6-like_domain"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03296">
        <property type="entry name" value="M6dom_TIGR03296"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014734757" evidence="1">
        <location>
            <begin position="29"/>
            <end position="425"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN08812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="425" mass="45388" checksum="9D31799B191F5142" modified="2018-04-25" version="1">MRQRIRRARRSAGLAGLTAVVLAVTTSASTGRLIEQSPSPSGSGSASLSRPAALNPCMIQGALGVQMSEGMPTQPGYARSTGTVHALNLMVDFSDAPGQGTALDRLGEFFPQTKDWFRTGSYGKLDYRPEAPIRHWLRMPRTFAEYGIARGAPFDPGYRDLVDDIVAKADPDVDFRDYDLINILVTPNAGPSALDTVLSVTFAGNHEAPVADGVHVANASFVYSRQDDGSGSYAETGYRVLPHENGHTFGLPDLYTQDGGGAVGHWDIMSEDWGAGNDLLGWHKWKLGWLGDNQVSCASAHGTSEHTLSPLGVKGGPKLIFVPLTAKTGFAIEVRTREGNDEAVCRPGVLIYRVNADVDTGLGPITVEDATKDSGGCTRSPNVHAELSDAAFTSGETFKDPKTGVKIKVAAADQKGDYRVLVTRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JPQ2</accession>
    <name>A0A2M9JPQ2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MarR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_25485</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000011">
        <property type="protein sequence ID" value="PJN08852.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08852">
        <property type="protein sequence ID" value="PJN08852"/>
        <property type="gene ID" value="CG723_25485"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000835">
        <property type="entry name" value="HTH_MarR-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12802">
        <property type="entry name" value="MarR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00347">
        <property type="entry name" value="HTH_MARR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50995">
        <property type="entry name" value="HTH_MARR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH marR-type" evidence="1">
        <location>
            <begin position="1"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN08852.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="158" mass="18310" checksum="80A5728AE92E7D5B" modified="2018-04-25" version="1">METETATRWLTDEEQCAWRTHVEVNRMLTYQLEKDLQPFGLTMNDYDILVHLSETDDHRMRMSDLATATLQSKSRLSHQITRMENAGLVRRENCESDRRGLYTVLTEDGMATMKKVAPHHVASVRRHFVDLIPSEELDALHKALTPIAEHLRSQRGKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-09-29" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JQD9</accession>
    <name>A0A2M9JQD9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CG723_24540</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CB01635</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000010">
        <property type="protein sequence ID" value="PJN09093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN09093">
        <property type="protein sequence ID" value="PJN09093"/>
        <property type="gene ID" value="CG723_24540"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004638">
        <property type="entry name" value="EmrB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00711">
        <property type="entry name" value="efflux_EmrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="24"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="55"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="90"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="115"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="149"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="177"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="211"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="243"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="280"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="316"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="345"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="374"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="409"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="451"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="24"/>
            <end position="478"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PJN09093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="481" mass="49243" checksum="AD4F623DC5982E35" modified="2018-04-25" version="1">MAAVSAPLRALPALLAPQRSRWPALGVLATGMLMTVLDGSIVTVAMPAIQNDLGFTPAGLSWVVNAYLIAFGSLLLLAGRLGDLVGRKRLFLAGTVVFTAASLLAGVATSPEVLIAARFLQGVGSALASAVSLGILVTLFTEPRERARAIAVFSFTGAAGASIGQVLGGVLTDALSWHWIFFINLPIGLAALAVAVPALPRDRGLGLRAGADTAGALLVTGGLMLGIYSVVKVEEYGWTSARTLGTGAVAALLLAGFFVRQARARTPLMPLRILRSRSVAGANLVQMLMVAALFSFQILVALYLQNVLGYGAAETGLAMLPAAAVIGAVSLGVSARLGARFGERNVLLTGIVLLIGVLGLLARVPVHAHYATDILPVMFLAAGFGLALPALTSLGMSGASEADAGVASGLFNTTQQIGMAVGVAVLSTLAASRTRSLTAHGATRAEALTSGYHLAFTVGTGLLVAAFLIAYMVLRRPRTTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JQE2</accession>
    <name>A0A2M9JQE2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PPOX class F420-dependent enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_24535</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000010">
        <property type="protein sequence ID" value="PJN09092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN09092">
        <property type="protein sequence ID" value="PJN09092"/>
        <property type="gene ID" value="CG723_24535"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019920">
        <property type="entry name" value="F420-binding_dom_put"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011576">
        <property type="entry name" value="Pyridox_Oxase_put"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01243">
        <property type="entry name" value="Putative_PNPOx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03618">
        <property type="entry name" value="Rv1155_F420"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Putative_PNPOx" evidence="1">
        <location>
            <begin position="14"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN09092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="154" mass="17080" checksum="402E472E99A22B5C" modified="2018-04-25" version="1">MTAKSGPAPRILTDEELQLLLSRSRFGTLASVRRTGHPHLSTVLYHWSPEERVVRVSTTADRLKARRLRSDPHAALHVSGPDVWSFAVAEGEAEVSEVTASPGDAVGRELLAMTPGFDNPEQETEFLAQLVEERRVVIRLRVCRLYGTALDIPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JQP8</accession>
    <name>A0A2M9JQP8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Copper-translocating P-type ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CG723_25095</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CB01635</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000010">
        <property type="protein sequence ID" value="PJN09188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN09188">
        <property type="protein sequence ID" value="PJN09188"/>
        <property type="gene ID" value="CG723_25095"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019829">
        <property type="term" value="F:ATPase-coupled cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00371">
        <property type="entry name" value="HMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017969">
        <property type="entry name" value="Heavy-metal-associated_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006121">
        <property type="entry name" value="HMA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036163">
        <property type="entry name" value="HMA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027256">
        <property type="entry name" value="P-typ_ATPase_IB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00403">
        <property type="entry name" value="HMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55008">
        <property type="entry name" value="SSF55008"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="SSF81653"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="SSF81665"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01525">
        <property type="entry name" value="ATPase-IB_hvy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01047">
        <property type="entry name" value="HMA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50846">
        <property type="entry name" value="HMA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-1278">Translocase</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="109"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="132"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="170"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="213"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="366"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="392"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="708"/>
            <end position="725"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="731"/>
            <end position="749"/>
        </location>
    </feature>
    <feature type="domain" description="HMA" evidence="10">
        <location>
            <begin position="17"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="79"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU362081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PJN09188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="758" mass="78054" checksum="1EA5432D01C367E1" modified="2018-04-25" version="1">MSAHPVATAPSAAQAAEVELAIGGMTCASCAARIEKKLNRMDGVAATVNYATEKAKVTFADGVAVADLIATVEATGYTAQEPSATDEEKAEEAESQASADSLAPLRQRLVTAVVLAVPVVAMAMIPALQFEYWQWLSLTLTAPVVTYAAWPFHKAAFTNARHGAATMDTLISVGTSAAFLWSVWALFFGTAGMPGMTHAFELTIARSDGAGNIYLEAAAGVTAFILAGRYFEARSKRKAGAALKALLELGAKNVTLVREGGREETVPVAGLKAGDRFLVRPGEKIATDGAVVEGASAVDASMLTGESVPVEVAVGDAVTGATLNVGGRLVVEATRVGADTQLARMARLVEDAQNGKAAAQRLADRISAVFVPVVIGLALATLGFWLGNGAGITAAFTAAVAVLIIACPCALGLATPTALMVGTGRGAQLGILIKGPEVLETTRAVDTIVLDKTGTVTTGRMTLLAIHVADGTDTGEVLRVAGALEHSSEHPIAQAIADGAREKVGELGAVEDFANLPGLGVQGIVDGHAVLVGREKLLAEWEIRLPVELERAKAEAEAAGRTAVAVAWDGEARAVLEVADAVKETSAEAVRRLRGLGLTPILLTGDNEAVARSVAAEVGIDEVIAEVMPQDKVDVVKRLQGEGRSVAMVGDGVNDAAALAQADLGLAMGTGTDAAIEAGDLTLVRGDLRAAADAIRLSRRTLGTIRTNLFWAFAYNVGALPLAAAGLLNPMIAGAAMAFSSVFVVGNSLRLRNFRPQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JQS6</accession>
    <name>A0A2M9JQS6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_25250</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000010">
        <property type="protein sequence ID" value="PJN09218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN09218">
        <property type="protein sequence ID" value="PJN09218"/>
        <property type="gene ID" value="CG723_25250"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002397">
        <property type="entry name" value="Cyt_P450_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00359">
        <property type="entry name" value="BP450"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="SSF48264"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0349">Heme</keyword>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN09218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="420" mass="45392" checksum="6E8DF36A8A9201DE" modified="2018-04-25" version="1">MHLPRERQQFATTGATPMPRIALDPFVTDLDTESAALRAAGPLAEAELPGGVPVWAVTHHTEARQLLNDRRLVKDIEVWGAWRRGEIPADWPLIGLANPGRSMLTVDGEDHRRLRTLVAQALTPRRVELMRDRIALRTEELLDALPDDGTTVDLKAAFAYPLPMYVIADLMGIDDSALPRLKVLFEKFFSTQTPPAEVVATLTELAGIMAATVASRRAEPGEDLTSALILASGDDGDRLTDEEIVSTLQLMVAAGHETTISLIVNAVVNLSAHPEQLAQVLSGDVPWEAVVEETLRHSTPTSHVLIRFAAEDVPVGGKVIAKGDALIVSYGAIGRDEQAHGPTAGAFDVTRTSPNRHISFGHGPHVCPGAALSRLEAAVALPALYARFPDLTLAVPPTSLRHKPVVTQNDLFELPVRLLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JRG6</accession>
    <name>A0A2M9JRG6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CG723_22190</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000008">
        <property type="protein sequence ID" value="PJN09480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN09480">
        <property type="protein sequence ID" value="PJN09480"/>
        <property type="gene ID" value="CG723_22190"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002514">
        <property type="entry name" value="Transposase_8"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01527">
        <property type="entry name" value="HTH_Tnp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PJN09480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="77" mass="8752" checksum="6C5FB053A47077FE" modified="2018-04-25" version="1">MGSNYTKRYSEEFKRDAIALVASSGGTVTDMARELGIDGHFTEDLEPSELIRPGRWKRRSTLQRAREAAVVPIRRFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-05-25" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JRR3</accession>
    <name>A0A2M9JRR3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">LacI family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CG723_22610</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000008">
        <property type="protein sequence ID" value="PJN09538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN09538">
        <property type="protein sequence ID" value="PJN09538"/>
        <property type="gene ID" value="CG723_22610"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01392">
        <property type="entry name" value="HTH_LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000843">
        <property type="entry name" value="HTH_LacI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046335">
        <property type="entry name" value="LacI/GalR-like_sensor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00356">
        <property type="entry name" value="LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13377">
        <property type="entry name" value="Peripla_BP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00036">
        <property type="entry name" value="HTHLACI"/>
    </dbReference>
    <dbReference type="SMART" id="SM00354">
        <property type="entry name" value="HTH_LACI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50932">
        <property type="entry name" value="HTH_LACI_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH lacI-type" evidence="4">
        <location>
            <begin position="14"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PJN09538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="339" mass="35822" checksum="71FBBC4F1005C316" modified="2018-04-25" version="1">MPTPRTSRRGRHGVTIDDVARSAGVSRQTVSRAINDKPEIDPDTRARILEVAQTLGYRPNRHARGMAGPATTMLGLVVADVLNPFFPEVVAGVMEAADERGWQVAVYSTGSALEREQTVAATVADHVDACVGYFFAESAIERVRGTGIPLVLLDHDTRPPAAGGVRIDFESGMRQALGHLMAAGHRRVVMLDDKARGDGADPHSRRALFLALAAEHGLDAEGTPVVSVANSVQGGADGMDRVLAHHPGTTAVLGYNDLIAVGAMRRALGRGLAVPGDCAFVGCDGLMLGELMDPPLTTLHVDKRQVGRAAVEQVAALVQGRGPLAERVIVPRLVVRESA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-09-29" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JS89</accession>
    <name>A0A2M9JS89_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Allantoin permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CG723_21180</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CB01635</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the purine-cytosine permease (2.A.39) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000007">
        <property type="protein sequence ID" value="PJN09718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN09718">
        <property type="protein sequence ID" value="PJN09718"/>
        <property type="gene ID" value="CG723_21180"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001248">
        <property type="entry name" value="Pur-cyt_permease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026030">
        <property type="entry name" value="Pur-cyt_permease_Fcy2/21/22"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31806">
        <property type="entry name" value="PTHR31806"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02133">
        <property type="entry name" value="Transp_cyt_pur"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002744">
        <property type="entry name" value="Pur-cyt_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="32"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="59"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="146"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="175"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="208"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="249"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="290"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="330"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="357"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="398"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="443"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR002744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PJN09718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="482" mass="50942" checksum="FF81761A7F3CAE52" modified="2018-04-25" version="1">MSKTAESEGALETRGIEPVPESERTARTRELFPTWVAANISVLLLTMGASLVVSYKLNFWQALVVAIAAPIVSYGLVGLIGIAGKRGGAPGMALSRAVFGQRGNLLPGSLIWVARWGWETINAVTGAYAVLTVLDILFGVKSNNVLVIVTLLLFVVTTFVISGLGINAVQKCNKYATYLFGLFSVLVLAYLIANTDWTRVFDQPAGKMSLMVAGIGLIAAGGVSWIPSSPDFTRYLPRTASSVAIVRNSVGGAGIVVLPMVLMGAVMAVSTPDLASAADPVSFLGEILPLWIAVPYLLIALVGMLLINSMSMYSAGFTAQTLGFKVPRHWAVSINALISLIFGGILMLVATSFMGSFIAFLSLLAVAFSAWVGVFGADMLRRKEYDAEALVDTTRTSAYWYTGGFSPAAVASWAIGLLGGLMFTTSDWFTGPLAANNPIGEYGLGWVATIVISGLLYVVLPKPAVAATSEISAEEERETLAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-05-25" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JSB9</accession>
    <name>A0A2M9JSB9_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">UPF0102 protein CG723_21335</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_21335</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the UPF0102 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000007">
        <property type="protein sequence ID" value="PJN09748.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN09748">
        <property type="protein sequence ID" value="PJN09748"/>
        <property type="gene ID" value="CG723_21335"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1350.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00048">
        <property type="entry name" value="UPF0102"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011335">
        <property type="entry name" value="Restrct_endonuc-II-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011856">
        <property type="entry name" value="tRNA_endonuc-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003509">
        <property type="entry name" value="UPF0102"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34039">
        <property type="entry name" value="PTHR34039"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02021">
        <property type="entry name" value="UPF0102"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52980">
        <property type="entry name" value="SSF52980"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN09748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="127" mass="13499" checksum="B29C77BBBC850E38" modified="2018-04-25" version="1">MNASKARSALGKYGEELAARRLAESGMTVIERNWRAGRTGEIDIVAREGDALVVCEVKTRRAGGPAGSFEHPMAGVTPVKAQRLRDLAERWVQEHGGAPPGGVRIDLVGVLLPERGAPVVEHARGVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JSD6</accession>
    <name>A0A2M9JSD6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">AsnC family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_21075</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000007">
        <property type="protein sequence ID" value="PJN09697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_016642988.1">
        <property type="nucleotide sequence ID" value="NZ_NNBL01000007.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN09697">
        <property type="protein sequence ID" value="PJN09697"/>
        <property type="gene ID" value="CG723_21075"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019887">
        <property type="entry name" value="Tscrpt_reg_AsnC/Lrp_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01037">
        <property type="entry name" value="AsnC_trans_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AsnC_trans_reg" evidence="1">
        <location>
            <begin position="6"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN09697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="77" mass="8233" checksum="7FA568CD34EBAF57" modified="2018-04-25" version="1">MVQAYILIQTEVGKASTVAELIGKIPGVIQAEDVTGPYDVIVRAQADTVDELGRMVVAKVQQVDGITRTLTCPVVHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JSG6</accession>
    <name>A0A2M9JSG6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Serine/threonine protein kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_21810</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000007">
        <property type="protein sequence ID" value="PJN09831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN09831">
        <property type="protein sequence ID" value="PJN09831"/>
        <property type="gene ID" value="CG723_21810"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="168"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN09831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="315" mass="32546" checksum="BFD097AA7BF3451C" modified="2018-04-25" version="1">MRTPGAVATGVRIGPYAPITRLDDRTSRSPVPEHRYIARTPDGDRTVLVSVPLPGTDPQRYMTEADASRYLLGPWASPATELAAPGDSPWHARPYLPALPLPTALAVHGGPLPEHTVRALGAALAETLVVAHGQNLTHAGVSPAAVLLAADGPRLTCFGAVRAAAPDGTSRSGLPGLDPGSFPPEQAAGGRPRPLGDVYALGATLAYAAAGHTAPERDELPSSLRSLVGRCLSRDPGARPQLAELLDEFAPETAAGPSGFQAASRATALFAPGWLPARVIAAIVHQSAAVLAAEIVPPERPAWAPPLPVSAHRQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JSI5</accession>
    <name>A0A2M9JSI5_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 5">30S ribosomal protein S15</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">rpsO</name>
        <name evidence="7" type="ORF">CG723_21855</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CB01635</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome.</text>
    </comment>
    <comment type="function">
        <text evidence="3 6">One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it helps nucleate assembly of the platform of the 30S subunit by binding and bridging several RNA helices of the 16S rRNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Part of the 30S ribosomal subunit. Forms a bridge to the 50S subunit in the 70S ribosome, contacting the 23S rRNA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 4">Belongs to the universal ribosomal protein uS15 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000007">
        <property type="protein sequence ID" value="PJN09836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN09836">
        <property type="protein sequence ID" value="PJN09836"/>
        <property type="gene ID" value="CG723_21855"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00353">
        <property type="entry name" value="Ribosomal_S15p_S13e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01343_B">
        <property type="entry name" value="Ribosomal_S15_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000589">
        <property type="entry name" value="Ribosomal_S15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005290">
        <property type="entry name" value="Ribosomal_S15_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009068">
        <property type="entry name" value="S15_NS1_RNA-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23321">
        <property type="entry name" value="PTHR23321"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00312">
        <property type="entry name" value="Ribosomal_S15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01387">
        <property type="entry name" value="Ribosomal_S15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47060">
        <property type="entry name" value="SSF47060"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00952">
        <property type="entry name" value="S15_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00362">
        <property type="entry name" value="RIBOSOMAL_S15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="1 3 4" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3 6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 6" id="KW-0699">rRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU004524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PJN09836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="95" mass="10838" checksum="D0C6AAC76F6AA7D7" modified="2018-04-25" version="1">MSLDAATKKQIITEFGQKEGDTGSPEVQVAMLSRRISDLTEHLKTHKHDHHSRRGLLILVGQRRRLLQYLAKKDIQRFRALVERLGIRRGAAGAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JSJ0</accession>
    <name>A0A2M9JSJ0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GNAT family N-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_21575</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000007">
        <property type="protein sequence ID" value="PJN09861.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN09861">
        <property type="protein sequence ID" value="PJN09861"/>
        <property type="gene ID" value="CG723_21575"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025289">
        <property type="entry name" value="DUF4081"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016794">
        <property type="entry name" value="UCP21603_acetyltransf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13312">
        <property type="entry name" value="DUF4081"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF021603">
        <property type="entry name" value="UCP21603_acetyltransf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="145"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN09861.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="287" mass="31199" checksum="BE31E41CA3B009A8" modified="2018-04-25" version="1">MRPPHVLTQTTTRVLEPSDLDAALAVLDREPVANAFVASRVQAAGLDPWRLGGEMWGWYEDGMLESLCYAGANLVPICATPRAVRGFADRARRAGRRCSSIVGPAEPTAQLWRLLEPNWGPARDVRAQQPLMVADRLPDGIAPDPYVRHVRKDEMETIMPACVAMFTEEVGVSPLAGDGGLLYQARVAELVGSGRSFARLDEHGKVIFKAEIGAATTRACQIQGVWIAPEHRGRGLAAPGMAAVLRYALADFAPLVSLYVNDFNTPARAAYRRVGFEEVGAFMSVLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JSK8</accession>
    <name>A0A2M9JSK8_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Histidine kinase</fullName>
            <ecNumber evidence="3">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CG723_19250</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CB01635</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="3"/>
    <dbReference type="EMBL" id="NNBL01000006">
        <property type="protein sequence ID" value="PJN09881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN09881">
        <property type="protein sequence ID" value="PJN09881"/>
        <property type="gene ID" value="CG723_19250"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00672">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00304">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 11" id="KW-0418">Kinase</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="31"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="10">
        <location>
            <begin position="222"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="9">
        <location>
            <begin position="289"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="503"/>
            <end position="526"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PJN09881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="526" mass="56703" checksum="2B17ABD97CC16E84" modified="2018-04-25" version="1">MSDAHDRLRGWAAAKKAILAGLRFTSLRLRLVVVFALVALTAAVSASGIAYWLNREAVLTRAQDAALSDFQQEMQNRAAALPEHPTQGELQHAANLMASSSQHFSVLLISDDKDGRRIAGNSDLDAITLAEVPRSLRDAVNREQPLTDGNKHPYHLYWQRIVSNDTPYLVGGARVIDGGPTGYMLKSLEPEAKDLNSLAWSLGIATALALVGSALLAQAAATTVLKPVHRLGRAARRLGEGKLDTRLRVSGTDELADLSRTFNRTAENLEKKVADMSAREEASRRFVADMSHELRTPLTAITAVTEVLEEELDAETGSVDPMIEPAVRLVVSETRRLNDLVENLMEVTRFDAGTARLVLDQVDIADQITACIDARAWLDAVDLDAERGIMARIDPRRLDVIMANLIGNALKHGGSPVRVSVRLADSELVIEVRDHGPGIPQDVLPHVFDRFYKASASRPRSEGSGLGLSIALENAHIHGGEITAANSPEGGAVFTFRLPLDASPLTLPPDDEGADVGGSGEEGGPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JSW2</accession>
    <name>A0A2M9JSW2_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">HTH cro/C1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CG723_19730</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000006">
        <property type="protein sequence ID" value="PJN09960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN09960">
        <property type="protein sequence ID" value="PJN09960"/>
        <property type="gene ID" value="CG723_19730"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021224">
        <property type="entry name" value="DUF2690"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10901">
        <property type="entry name" value="DUF2690"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="219"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="domain" description="HTH cro/C1-type" evidence="3">
        <location>
            <begin position="22"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="113"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="242"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PJN09960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="376" mass="38831" checksum="203868072DCE63A0" modified="2018-04-25" version="1">MPRWRALPDELDPQVREFASQLRRLVDRSGLSIAAVADRTGYSKTSWERYLNGRLLAPKRAIVTLAEVTGTNPVHLTTMWELAERAWSRSEMRHDMTMEAIRISQARAALGEFGPTATKDGKNGSGGAGGGSRTTARPSGGGATGVAPTVPPQGQAPLADSVPYGSEREHGFRPGERAGEGVPYASGPGAYAGGGGGGPAGQPGTGGGSPDRQRRKRRLTMFLAGVVGALVVIAAAVYLTDAGKGGKDDDAKPEATPTSSAPELPAGVECSGKDCTGKDPEAMGCGGEFARTTDSVLVGQAKIEVRYSKTCGAAWARITQAAPGDEVRIQQAGTTGVQKGTVNADFDAYTPMVAVTKASEAKACATLKAGRQGCTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JT67</accession>
    <name>A0A2M9JT67_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">30S ribosomal protein S14 type Z</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">rpsZ</name>
        <name evidence="5" type="synonym">rpsN</name>
        <name evidence="6" type="ORF">CG723_20265</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CB01635</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="5">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Part of the 30S ribosomal subunit. Contacts proteins S3 and S10.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the universal ribosomal protein uS14 family. Zinc-binding uS14 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000006">
        <property type="protein sequence ID" value="PJN10053.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003948630.1">
        <property type="nucleotide sequence ID" value="NZ_NNBL01000006.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A2M9JT67"/>
    <dbReference type="EnsemblBacteria" id="PJN10053">
        <property type="protein sequence ID" value="PJN10053"/>
        <property type="gene ID" value="CG723_20265"/>
    </dbReference>
    <dbReference type="GeneID" id="63982137"/>
    <dbReference type="GeneID" id="66955253"/>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.830.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01364_B">
        <property type="entry name" value="Ribosomal_S14_2_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001209">
        <property type="entry name" value="Ribosomal_S14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043140">
        <property type="entry name" value="Ribosomal_S14/S29"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018271">
        <property type="entry name" value="Ribosomal_S14_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023053">
        <property type="entry name" value="Ribosomal_S14_Z"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19836">
        <property type="entry name" value="PTHR19836"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00253">
        <property type="entry name" value="Ribosomal_S14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00527">
        <property type="entry name" value="RIBOSOMAL_S14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 5 6" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0699">rRNA-binding</keyword>
    <keyword evidence="2 5" id="KW-0862">Zinc</keyword>
    <feature type="binding site" evidence="5">
        <location>
            <position position="24"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="27"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="40"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="43"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PJN10053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="61" mass="6949" checksum="BCAD093782CDB444" modified="2018-04-25" version="1">MAKKALIAKAARKPKFGVRGYTRCQRCGRPHSVYRKFGLCRVCLREMAHRGELPGVTKSSW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-09-29" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JTK9</accession>
    <name>A0A2M9JTK9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_17545</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000005">
        <property type="protein sequence ID" value="PJN10203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN10203">
        <property type="protein sequence ID" value="PJN10203"/>
        <property type="gene ID" value="CG723_17545"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010290">
        <property type="entry name" value="TM_effector"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05977">
        <property type="entry name" value="MFS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="21"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="51"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="83"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="110"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="149"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="178"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="228"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="263"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="292"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="381"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="406"/>
            <end position="441"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN10203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="441" mass="44917" checksum="0CAFAED9E7FF00CE" modified="2018-04-25" version="1">MKARARFLDTRPLRGSRPFRHLCIGTSASQLGGQITTVAVLAQVWELTGSTVGTGAIGLATGLPMVLFGLIGGTLADSVDRRALVRATTAGQLLVAAGLSAQALAGNRNVFLLLALVAAGTACGALGAPARRTFPVRLLPADQVAAGLALTNISFQVAMLAGPALLAGLIIARWDLPAAYAAQAVATVVSILAVISLPAMRPESVDAAVAKRRPERGGRRIVLRRPTLWGSMVTDLSATLLAMPIALFPLVNEIRFGGNPQTLGLFLSAIAVGGITAGLLSGTVTRWRRGGLVQLGAAAVWGLALAGFGLSGPLWPALGCLAVAGAADTVSVVTRSALVQLETPDAYRGRVSSVEHVIGVAGPELGNFRGGLMASATSAPFALVAGGLSATLAVATVAATNASLRAYRTPRTPNNRRSEEPYGGPSSGTADVALKYDGSET</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JU76</accession>
    <name>A0A2M9JU76_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Molybdate ABC transporter substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">modA</name>
        <name evidence="6" type="ORF">CG723_18600</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CB01635</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial solute-binding protein ModA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000005">
        <property type="protein sequence ID" value="PJN10378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN10378">
        <property type="protein sequence ID" value="PJN10378"/>
        <property type="gene ID" value="CG723_18600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015689">
        <property type="term" value="P:molybdate ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005950">
        <property type="entry name" value="ModA"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004846">
        <property type="entry name" value="ModA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01256">
        <property type="entry name" value="modA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0500">Molybdenum</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014915959" evidence="5">
        <location>
            <begin position="35"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="29"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="63"/>
        </location>
        <ligand>
            <name>molybdate</name>
            <dbReference type="ChEBI" id="CHEBI:36264"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="91"/>
        </location>
        <ligand>
            <name>molybdate</name>
            <dbReference type="ChEBI" id="CHEBI:36264"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="197"/>
        </location>
        <ligand>
            <name>molybdate</name>
            <dbReference type="ChEBI" id="CHEBI:36264"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="215"/>
        </location>
        <ligand>
            <name>molybdate</name>
            <dbReference type="ChEBI" id="CHEBI:36264"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR004846-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PJN10378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="279" mass="28709" checksum="F0958B6F82FCF46A" modified="2018-04-25" version="1">MTRYARRTRRTLQVAGVGVAALLALSACSSGSDSSSKKDSSSSASADSSKKLTGTVTVFAAASLKESFTTLGKDFEKAHPGTKVTFSFGGSDTLAASITGGAPADVFAAASPKTMAIVTDKKDGKGTATAPSTFVRNQLEIATLPGNPDKVASLKDLTKSDLKVVLCDKTVPCGAAAQKALDASKLKLTPASYEQDVKSALTKVELKEADAAVVYKTDVKAAGNKVEGVEFPESADAINDYPIALLKDAPNAEAAKEFIALVQSPEGQKVLTAAGFLKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JUM0</accession>
    <name>A0A2M9JUM0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_15185</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000004">
        <property type="protein sequence ID" value="PJN10563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN10563">
        <property type="protein sequence ID" value="PJN10563"/>
        <property type="gene ID" value="CG723_15185"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="688"/>
            <end position="711"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="724"/>
            <end position="747"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="729"/>
            <end position="747"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN10563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="747" mass="81941" checksum="88156AF56355AA40" modified="2018-04-25" version="1">MPTYHEIMTTDLATLTTAADRWDGMAKEFGKRETDYKRDVHGITPGPPSPSTWTGLSADAAGKRFDVTLHEFQNAQTEAKAIASLLRDAHAQFTNLRGQLKSEREAAVKAGIRVSDRGVVAYDEERAAASESGSAMHDPGSRAEVHRAVASWQGRIDKAVRAVGDADTGVEIALGAAVFDSHLTDGTGNGFNARAKGDIEQYEADVAKESARKLANGERLTPHQLAELQRSFRDNSRDPEFSRTVLDSLGPSGTIRLTNNLGDLAHVTDPRHAADYNSLETGLANSLATATKNPHSKWYKNWRAEMREAGVARYETDFQAARLDKVHGYQSLVTLMQHGDGYGRDFLEDLGDDMIKAEKKNPEIWDLKGEYSEKRNGWFANDPVDGVLGIMSHEPAMAAHYLNDDDRMKYLMHDRDWKIALHTNETPKATVYTPSLDTDTRAGFAAALQAGATGLDPSDPNAKYVDHSADNNKVFKSSLKYLAEEGDKFPPSLREPMAKILVNHGDTVHAAAGAIDMNEAPLEQDQLYEVVKQVSKDQDSYATLNSGINHAIVADIHGPNQKHPEDSLTHAGRTVGFLEQARSNAAGDPKVAEFKHKWVVDQAIGYLPVAGDEVQSGVDFVTERWLADEQKKLDDKTAEDNVADYTKRNRQLMALSGEWHKVHGSHGGSAIAAQEAIDEAAYAAASNEAGALQGRRRNDPPNADRATDPGFTFRDCTVRLQFPASRNPEIHLRHARSPESHRATTES</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JUS8</accession>
    <name>A0A2M9JUS8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CG723_15295</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CB01635</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000004">
        <property type="protein sequence ID" value="PJN10582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN10582">
        <property type="protein sequence ID" value="PJN10582"/>
        <property type="gene ID" value="CG723_15295"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018929">
        <property type="entry name" value="DUF2510"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010432">
        <property type="entry name" value="RDD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10708">
        <property type="entry name" value="DUF2510"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06271">
        <property type="entry name" value="RDD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="373"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="416"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="482"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="domain" description="DUF2510" evidence="8">
        <location>
            <begin position="16"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="domain" description="RDD" evidence="7">
        <location>
            <begin position="367"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="55"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="217"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="293"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF06271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF10708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PJN10582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="522" mass="53923" checksum="58D8065E9DC336D1" modified="2018-04-25" version="1">MSAPTPAPGDDRPRDGYYPDPSIPGYVRYWNGAAWVPGTSRPAPSDGEPLAAPAGVTPAPAPSPSPSPSPSPLPVEETGPVFLDEEPERYSDEPAAPEPATAWQADASHQTGFGGEQDRRVSWGADPRVPAPPQEERTDGALTARPAQPEPPTPPTDGTVTFRRPTPSVDRPEGTMTMRALSAPQVPGQQLPAAQGPVAQGQGPASQEAAGRHAQGHQGHQGQQGQQVEGRQAQQPAPQQANSQPLPHQGFAPQGPAQQPPAHQAQAPQAAPLQPHAPQAGRPGAVPPQAAAASATPMTSGPGGGSPSWAQQVHQLAQPGQSGQLGQSARPAAGEPAEPEGPVTPWKPVASDPFLAAAQAQASARPAGPGKRLAARLIDTVVLGAITAVAAVPLGTKAVDHIDGKIDAAKASGRQATVWLLDGTTGAYLGIVLAVLLVAGVLYEALPTAKWGRTLGKKVCGLQVRDIEEHAAPTFGAALRRWLVYSVTGLLAIGVVGVLWCLFDRPWRQCWHDKAARTFVAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JV84</accession>
    <name>A0A2M9JV84_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_15910</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000004">
        <property type="protein sequence ID" value="PJN10687.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN10687">
        <property type="protein sequence ID" value="PJN10687"/>
        <property type="gene ID" value="CG723_15910"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="78"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN10687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="145" mass="14808" checksum="8B89544DDCFD9BE8" modified="2018-04-25" version="1">MLEASLSTARHRPTQDHSAPPRDSASCDVVTVPARQGLEAVDILRRGATEAVGPVLHDGDCDTLGFLVPPGTADGWDVPGSACTHTPASSSQKRGPGAGPVPPAPVEGGGWLLPPGEAELVTDPTVLRAALDEAARMIEAADNCC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JVA4</accession>
    <name>A0A2M9JVA4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Amino acid transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CG723_16675</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CB01635</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the amino acid-polyamine-organocation (APC) superfamily. Amino acid transporter (AAT) (TC 2.A.3.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000004">
        <property type="protein sequence ID" value="PJN10810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN10810">
        <property type="protein sequence ID" value="PJN10810"/>
        <property type="gene ID" value="CG723_16675"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006865">
        <property type="term" value="P:amino acid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004841">
        <property type="entry name" value="AA-permease/SLC12A_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004840">
        <property type="entry name" value="Amoino_acid_permease_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00324">
        <property type="entry name" value="AA_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00218">
        <property type="entry name" value="AMINO_ACID_PERMEASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="33"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="62"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="100"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="141"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="171"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="217"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="260"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="298"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="342"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="373"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="419"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="443"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="domain" description="AA_permease" evidence="9">
        <location>
            <begin position="32"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PJN10810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="474" mass="50011" checksum="923FAA714AC5B13C" modified="2018-04-25" version="1">MSRTSAQSPVDAQPIDQSPAEPSLSRGLKQRHLSMIALGGVIGAGLFVGSGTAIAAAGPSIILAYAISGALVMLVMRMLGEMSAAYPASGSFSVHSERAIGPWAGFTAGWAFWFLLCVAVGLEGIGAAGIVHGWLPGVPEWALVALFMLLFTGTNLAAVKNFGEFEFWFATLKVGAIVLFLVIGVLAILGVLPDVSAPGMDNLTGHGGFMPNGTEGLIVGLLASVFAYGGLETVTIAAAESEHPVQGVARAVRTAMWRIALFYVGSMAVVVVLLPWTAKEIPTKGPYVATLDHLGIPGAGQIMNVVVLIALLSAMNANIYGASRMASSLVARGMGPKAIGKVTGGVPRVAVLISAAFGFVCVLLSYWRPDDVFAWLLNTIGAIILVVWFFIAISQLLLRRKLEREAPEKLVVKMWAYPYLTVLALVAMVVVFVLMAREHDTRVQLYYTGGLTIVLAIVGYVRQKRAESRAATAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JVH1</accession>
    <name>A0A2M9JVH1_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Cell shape-determining protein MreB</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">mreB</name>
        <name evidence="3" type="ORF">CG723_16790</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Forms membrane-associated dynamic filaments that are essential for cell shape determination. Acts by regulating cell wall synthesis and cell elongation, and thus cell shape. A feedback loop between cell geometry and MreB localization may maintain elongated cell shape by targeting cell wall growth to regions of negative cell wall curvature.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Forms polymers.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <text evidence="2">Membrane-associated.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the FtsA/MreB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000004">
        <property type="protein sequence ID" value="PJN10828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN10828">
        <property type="protein sequence ID" value="PJN10828"/>
        <property type="gene ID" value="CG723_16790"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000902">
        <property type="term" value="P:cell morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd10225">
        <property type="entry name" value="MreB_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02207">
        <property type="entry name" value="MreB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004753">
        <property type="entry name" value="MreB"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01652">
        <property type="entry name" value="SHAPEPROTEIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00904">
        <property type="entry name" value="mreB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0133">Cell shape</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="9"/>
            <end position="11"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="151"/>
            <end position="153"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="199"/>
            <end position="202"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="282"/>
            <end position="285"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN10828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="332" mass="34672" checksum="C436911977272865" modified="2018-04-25" version="1">MDIGIDLGTANTLLYVRGKGIVLNEPSVVALKQNKTTVAVGTEAKEMLGRTPGSITTIRPLRDGVISDYEAAEEMLRHFVRKAVPGRRPRTRMVICVPSGVTPVERRAIVHAAQRAGARAVHVIEEPMAAAIGAGLPVAEARGSMVVDIGGGTTEVAVISLGGIVTAQSLRVGGDRMDVAITDHVRKEHGLLIGERTAEAVKLAIGSAAPAEELSETGTFTVRGRQRLAGLPHTATLTTQEIREALNSPVEAIVSALRATLEECPPELSGDVMEHGIVLTGGGALLPGLDLRMTEATGIPVFPAEAPLDSVALGCGKCAEDFDSLQRLLTAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JVP8</accession>
    <name>A0A2M9JVP8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">MerR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CG723_08140</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN10975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN10975">
        <property type="protein sequence ID" value="PJN10975"/>
        <property type="gene ID" value="CG723_08140"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.490.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000551">
        <property type="entry name" value="MerR-type_HTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036244">
        <property type="entry name" value="TipA-like_antibiotic-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012925">
        <property type="entry name" value="TipAS_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13411">
        <property type="entry name" value="MerR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07739">
        <property type="entry name" value="TipAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00040">
        <property type="entry name" value="HTHMERR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00422">
        <property type="entry name" value="HTH_MERR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="SSF46955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89082">
        <property type="entry name" value="SSF89082"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00552">
        <property type="entry name" value="HTH_MERR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50937">
        <property type="entry name" value="HTH_MERR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0010">Activator</keyword>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH merR-type" evidence="6">
        <location>
            <begin position="1"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="77"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PJN10975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="267" mass="30374" checksum="CC1D7011C060FE72" modified="2018-04-25" version="1">MSYSVGQVSAFARVTVRTLHHYDKAGLLSPSDRSRAGYRLYSEADLVRLQQILFYRELGFSLDEIAVILREPQVNALEHLRARQRQLSEEIARLQRLAEVAERAIEVQQSGVSLTPQERFEVFGEITFDLSYATEAELKWAHSEGQREAMARATAHTKEDWRRLMGEAAAWRAELLAAFDEREPSDGERAMDLAEEHRLHISRWFTSCPPDMHRRIADDFVADPRAFALVVPQSQQRPGLAAYTCKAVHANAARHAGDRTDSEGEDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JW12</accession>
    <name>A0A2M9JW12_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Thioesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CG723_16400</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000004">
        <property type="protein sequence ID" value="PJN10947.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN10947">
        <property type="protein sequence ID" value="PJN10947"/>
        <property type="gene ID" value="CG723_16400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="SSF54637"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PJN10947.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="146" mass="16380" checksum="C7406BA5579B14C1" modified="2018-04-25" version="1">MVRHIYACPLRWSDMDAFGHVNNAVFVRYLEEARIDFMFQLAPGDGSPSFSGGSVVARHEIDYVRPLVHRHTPVTIESWVTKISAASLTIAYEIKDEDQLYVRASTVVVPFNLEAQRPRRITAEEKAYLKEYMDDSADSGSGALAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-05-25" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JW42</accession>
    <name>A0A2M9JW42_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Nitroreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_09060</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>a quinol + H(+) + oxidized coenzyme F420-(gamma-L-Glu)(n) = a quinone + reduced coenzyme F420-(gamma-L-Glu)(n)</text>
            <dbReference type="Rhea" id="RHEA:39663"/>
            <dbReference type="Rhea" id="RHEA-COMP:12939"/>
            <dbReference type="Rhea" id="RHEA-COMP:14378"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
            <dbReference type="ChEBI" id="CHEBI:133980"/>
            <dbReference type="ChEBI" id="CHEBI:139511"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the F420H(2)-dependent quinone reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN11106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN11106">
        <property type="protein sequence ID" value="PJN11106"/>
        <property type="gene ID" value="CG723_09060"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004378">
        <property type="entry name" value="F420H2_quin_Rdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04075">
        <property type="entry name" value="F420H2_quin_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00026">
        <property type="entry name" value="hi_GC_TIGR00026"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00029371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN11106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="165" mass="18392" checksum="0A5F60B54CF4203C" modified="2018-04-25" version="1">MFDDRSPLKAGSFPVTTIDWDHPTDPKPGTWQLDHVKQYVANGAEGQYWNGTQTLLLTTIGRKSGDPVRTPLIYGEADGAYLIVASKGGDPAHPLWYRNLQEHPEVRIQVGPIILQGTARTATAEERAAYWPLMVKHWPAYDEYQAKTDREIPIVVIEPTTAPGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JW57</accession>
    <name>A0A2M9JW57_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CG723_09235</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN11133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN11133">
        <property type="protein sequence ID" value="PJN11133"/>
        <property type="gene ID" value="CG723_09235"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006764">
        <property type="entry name" value="SAM_dep_MeTrfase_SAV2177_type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04672">
        <property type="entry name" value="Methyltransf_19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017393">
        <property type="entry name" value="MTase_SAV2177"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PJN11133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="271" mass="29968" checksum="7FD59EC5F549A424" modified="2018-04-25" version="1">MTTRQAGRDLDTSKAHSARMYDYFLGGKDHFEIDKEAALVAAQAHPGIYVTARENRAFMHRATHVLAQEHGIRQWLDIGTGVPTEPNLHQVAQSVALDARVVYADNDPLVLKYAERLMRSTTQGRTAYIEADVTDPDALMSAVEASEVLDFDQPIALSLNALMHFITDPHDPYAIIRRLLDPLPAGSALAMNHCTPDFDPDTWNKVAEVYTKSGSPVQFRSHNDVRRFFDGLDLIEPGIICCHRWRPAGPADGTEPADAEISLLAGVGIKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JW61</accession>
    <name>A0A2M9JW61_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Acyl-CoA dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CG723_09300</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CB01635</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN11145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN11145">
        <property type="protein sequence ID" value="PJN11145"/>
        <property type="gene ID" value="CG723_09300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016627">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="SSF47203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="SSF56645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0274">FAD</keyword>
    <keyword evidence="3 5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA_dh_N" evidence="8">
        <location>
            <begin position="14"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_M" evidence="7">
        <location>
            <begin position="131"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_1" evidence="6">
        <location>
            <begin position="237"/>
            <end position="385"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PJN11145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="387" mass="42282" checksum="2A62370592DB690D" modified="2018-04-25" version="1">MTSAIFAERSLYEEDHELLRETVRAFVDKHATPHAERWRAEGKVDRELFQEAARAGILGFNIPEEYGGGGITDFRFNALIGEEFSRHPASDGLAGVGLSNDIVVPYFTGLTDDEQKARWLPGIAAGTLIVAVAMTEPGTGSDLAGIATSAVRDGDDYVVNGSKVFISNGQNADLVVTAVRTGADRHSGISLLVIEADRPGFSRGRNLEKIGLHAQDTSELFFQDVRVPAANLLGEEGSGFTALMRNLPQERISIAANAVASIEGVLERTVEYVRERKAFGRTVGSFQNTRFQLADMVTTARVGRTYVDELLSRHSRGELSAVEAASAKFWATENYVDIVGRCLQLHGAYGYMLEYRIAHDYLDSRITTIYGGTTEIMKEIVARDLGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JW89</accession>
    <name>A0A2M9JW89_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF397 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_09240</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN11134.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN11134">
        <property type="protein sequence ID" value="PJN11134"/>
        <property type="gene ID" value="CG723_09240"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007278">
        <property type="entry name" value="DUF397"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04149">
        <property type="entry name" value="DUF397"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF397" evidence="1">
        <location>
            <begin position="27"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN11134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="83" mass="8740" checksum="31CA5FC7DEF05BDB" modified="2018-04-25" version="1">MTITNEGVYNGMPAHNLGEHGWERPWSGPNGGQCVEAKQLADGRVAVRQSTDPAGPALIYTPEEIAAFVRGVKEGLADHLAAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JWJ1</accession>
    <name>A0A2M9JWJ1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CG723_10070</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN11271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN11271">
        <property type="protein sequence ID" value="PJN11271"/>
        <property type="gene ID" value="CG723_10070"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PJN11271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="137" mass="14646" checksum="3DDC840726390EE0" modified="2018-04-25" version="1">MNNDAPYPPDRTDDELARLDITVLLRYGLTAAPGTRRTALFGDGAAAAAVILDRLGTEPRSVAFLAETVRAGGLARAAELPEPLPRREAADLVREWLRAGTELVGGIAADDTAANWLRAVATIIELKQLTRARGRST</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JWK9</accession>
    <name>A0A2M9JWK9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Antibiotic biosynthesis monooxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_10035</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN11264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN11264">
        <property type="protein sequence ID" value="PJN11264"/>
        <property type="gene ID" value="CG723_10035"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007138">
        <property type="entry name" value="ABM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038762">
        <property type="entry name" value="ABM_predict"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40057">
        <property type="entry name" value="PTHR40057"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03992">
        <property type="entry name" value="ABM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51725">
        <property type="entry name" value="ABM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="227"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="257"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="299"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="domain" description="ABM" evidence="2">
        <location>
            <begin position="9"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="domain" description="ABM" evidence="2">
        <location>
            <begin position="113"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN11264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="321" mass="36226" checksum="250A8B0C011AFB76" modified="2018-04-25" version="1">MGIRASGSATVVTSQKVREGLDEEYDRWQGKVNRVVRDFDGFEATETYPPGSGEEREWVVVFRFAGTDQLTAWLESTARRELLAEGRGLLDGTPTQEVLAGGHIEVPDRVEGVTAVVSHDVRPGREEDFERWQEKILREQEKYPGFMGTEFFRPVEGIQDNWVIVFRYDTHEHLDVWLDSSSREHLLKEGRDYFASYDVHKVGTAFGGWFRFGSAEEEQVPPNWKQAMTVVLALYPTVMVLNLTVGHEFDVLGVPGYLGLFFGNILSVSILTWVLMPLVNRVLAFWLRPGRTRTVRVDVAGAALVALCWALTVLVFALTTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JWP3</accession>
    <name>A0A2M9JWP3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Alpha-1,3/4-fucosidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_10195</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN11294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN11294">
        <property type="protein sequence ID" value="PJN11294"/>
        <property type="gene ID" value="CG723_10195"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004560">
        <property type="term" value="F:alpha-L-fucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000933">
        <property type="entry name" value="Glyco_hydro_29"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10030">
        <property type="entry name" value="PTHR10030"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01120">
        <property type="entry name" value="Alpha_L_fucos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00812">
        <property type="entry name" value="Alpha_L_fucos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014696117" evidence="2">
        <location>
            <begin position="28"/>
            <end position="521"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN11294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="521" mass="57541" checksum="E8EF64BCC7E161EE" modified="2018-04-25" version="1">MTVSRRLFMAAAVTTAVAASSNSLALAAPAATRTTAEEPHYRIPISAADSPEELVAKASRVRPTKRQIAWQGLEKTAFLHFGVNTFTGLEWGTGDEDPNVFQPTGLDTDQWARALRDGGFKLAILTVKHHDGFVLYPSRYTGHSVASSSWRGGQGDVLRSFAGSMRKYGIKVGVYISPADENQYLDGVYANGSKRSARAIPTLVDGDDRAGDSPRTFTLDATDYGAHMLNQLYEVLTEYGPVDEVWFDGAQGRIPPEKVETYDWDSWYALIRALAPGATMAVRGPDVRWVGNEGGLAREDEWSVVPVKDSGNGSVDYALRYDAPDQGSRDALAQSRSVAQYLQWWPAECDVSIRPGWFYHADQQPKSVDQLADIWFRSVGRNSVLLLNIPPDTDGLLPAADVARLKEFRERIDRELPEDLADGARVRDDGEGIRTVDLRTAREVDRIRLAEDIRHGQQVEQFVVEAKSGGAWTEVARAGTIGASRVLVLPAPVTAREWRLRITQTRTGPHIARFGLYRSRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JX23</accession>
    <name>A0A2M9JX23_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Amino acid transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CG723_10210</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CB01635</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN11297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN11297">
        <property type="protein sequence ID" value="PJN11297"/>
        <property type="gene ID" value="CG723_10210"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="46"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="88"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="137"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="169"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="208"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="242"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="295"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="339"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="367"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="404"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="445"/>
            <end position="465"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PJN11297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="492" mass="51570" checksum="82004A1460E4DB00" modified="2018-04-25" version="1">MSSEPPGLRRSLGVVDGVAIAASSTAATTSIGIGMGALAATVGLQAPAILLVAFLPILGIASAYARLNRSEPNMGSGYVWVGKTLGPWPGFITGWVTLVGTVIFMAYTSAVTGSVFLQFANKAGWHHALGLTLDPNSTALSTVVGLAVLAVVTYTAITGVRKATRLQTWLLVFEYAVLLAFCGWALISGGHAFQWSWLNPFAIHDGTAFAQGLVLAVFFFWGWDAAFSVTEETKNVRDAGRGGFIALLTMLAMFLYGAVAFQREMSLPELIAQGPQGLTYLGAKLADEPWATLPLLALMFSAVASLQSSVIPTARGLLAMGRDRTMGQVWTRVSPRYGSPALGTVLIMSISAGVSVLALAIPKLNEMILAAVNSIGLVVALYYGLTALACAVRFRAALRGPLSGALRAVVAPTVSGVALLGIGAYLARSYVTMSDHFELSPDNGWFMLSVPLAIVASGLVMAAYAKYVRRSPYFVTGGGTAPETAPLTPEHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JXK6</accession>
    <name>A0A2M9JXK6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cupin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_12060</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN11615.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN11615">
        <property type="protein sequence ID" value="PJN11615"/>
        <property type="gene ID" value="CG723_12060"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013096">
        <property type="entry name" value="Cupin_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07883">
        <property type="entry name" value="Cupin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cupin_2" evidence="2">
        <location>
            <begin position="73"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN11615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="175" mass="18842" checksum="7450763770FF8B61" modified="2018-04-25" version="1">MATPSHAGDSPERDAFHPDLPDHDAPLPLRARLHHIRAGELDGDTAQTGGMRRFAAISGSTVGSERIWMGQTHVTPDTASSNHHHGASETAIHVVKGHPEFVFLDDSTGAPEEVRLRTAPGDYIFVPPYVPHREENPSPDEEAVVVIARSTQEAIVVNLPELYVLDQDSPSPAGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JY95</accession>
    <name>A0A2M9JY95_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CG723_13475</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN11842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN11842">
        <property type="protein sequence ID" value="PJN11842"/>
        <property type="gene ID" value="CG723_13475"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015833">
        <property type="term" value="P:peptide transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013563">
        <property type="entry name" value="Oligopep_ABC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08352">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01727">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="6">
        <location>
            <begin position="28"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="62"/>
            <end position="69"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PJN11842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="347" mass="37259" checksum="D8D038398A566AED" modified="2018-04-25" version="1">MSLLKRERDQPEKSRTETGLPGGSLLDLRGLGLAVPAGREWRPLVEEVDLSIGRGESVGLVGESGSGKSMTARTILGLTPPGARVTGDIVFDGIRVTDMDRRALRGLRAQRIAMVFQDPRAHINPVRSIGDFLTEAMIANLDVPAPEAKARAVRLLSDVGIADGERRMRQYPHELSGGLLQRVMIASVLAVEPDLILADEPTTALDVTTQSEVMAILDELRRERGTAMLLITHDLELAAATCDRLAVMYAGRIVETQAAGALTATPRHPYTSGLMLSRPSIDQVVHRLPVIPGRPLAAFEADDGCAFAPRCAHARPFCGDGRPAVMELEGARVACTRAGELTLQGES</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JYU4</accession>
    <name>A0A2M9JYU4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Transketolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CG723_14645</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CB01635</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN12040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN12040">
        <property type="protein sequence ID" value="PJN12040"/>
        <property type="gene ID" value="CG723_14645"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016744">
        <property type="term" value="F:transketolase or transaldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="CDD" id="cd02012">
        <property type="entry name" value="TPP_TK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009014">
        <property type="entry name" value="Transketo_C/PFOR_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005475">
        <property type="entry name" value="Transketolase-like_Pyr-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020826">
        <property type="entry name" value="Transketolase_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033248">
        <property type="entry name" value="Transketolase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005474">
        <property type="entry name" value="Transketolase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02779">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02780">
        <property type="entry name" value="Transketolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00456">
        <property type="entry name" value="Transketolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00861">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52922">
        <property type="entry name" value="SSF52922"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00802">
        <property type="entry name" value="TRANSKETOLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0786">Thiamine pyrophosphate</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Transket_pyr" evidence="7">
        <location>
            <begin position="305"/>
            <end position="468"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PJN12040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="615" mass="65770" checksum="4349C88C61F16AE2" modified="2018-04-25" version="1">MNTRQLSELAQQLRVDSIRASAAAGSGHPTSSMSAADLMAVLLANHMRYDFDRPAHPGNDRFVLSKGHASPLLYAAYKAAGAINDTELLTFRRLGSRLEGHPTPRQLPWVETATGSLGQGLPVAVGISLAGKRLDRTGYRVWVLCGDSELAEGSVWEAAEHAGYEHLDNLTAIVDVNRLGQRGPTRHGHDLHAYARRFQAFGWHTVEVDGHDVDAIDRAYDEALSTAGQPTAILARTLKGKGVASVQDREGLHGKPLPDAEEAIAELGGVRDLRVEVQHPSAARMLHPVGSGHADLPRYETGDEVATRDAYGKALAAVGTARGDVVALDGEVSDSTRSEFFAKEHPDRFFECYIAEQQMVATSVGMATRGWVPYASTFAAFLTRAYDFVRMASISGAGINLVGSHAGVAIGQDGPSQMGLEDLAMFRAMYGSTVLYPCDGNQTAKLVAEMADLEGIRYLRTSRGDTPVIYSPTEEFPIGGSKVLRASGEDRLTVVSAGVTLHEALKAAELLDREGIQVRVIDLYSVKPVDRSTLREAAESTGCLLTVEDHRAEGGIGDSVLDAFADGRPVPRLVRLAVRTMPGSATPAEQLHAAGIDAESIAAAARLLVETAVVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JYV5</accession>
    <name>A0A2M9JYV5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Enoyl-CoA hydratase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_14630</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the enoyl-CoA hydratase/isomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN12038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN12038">
        <property type="protein sequence ID" value="PJN12038"/>
        <property type="gene ID" value="CG723_14630"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018376">
        <property type="entry name" value="Enoyl-CoA_hyd/isom_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00166">
        <property type="entry name" value="ENOYL_COA_HYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN12038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="359" mass="38336" checksum="89E1E93080B89802" modified="2018-04-25" version="1">MVSRMPGVRSACGDHAPGLCEWVIGERVEGVSASGRRDRCLTVYSGWEGDCRIGRAAMRGVRALTAGLPPGRDERREELDMTASYETISTRLDGNVLSATFNAPPINLIGPELVRDLVGLLEELSRPATARVVVFDSADPDFFFPHVDLTKVSEYTAEAAKAGGPGDASLGMLFRRLSEIPAVTIAKLRGRARGAGSEFLLACDMRFASRENAVLCQPEVGIGTPPGAGAIQHLTRLLGRGRALEAVLTSADFDAELAERYGWINRAVPDAELDEFVAGIAARMGGFPRDALIAAKSAINAISLATPADVRADAALFQQLVRGEAAQQRTAELFQQGFQTRGRTELDLGDALGELKAVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-05-25" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JZ45</accession>
    <name>A0A2M9JZ45_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Heat-shock protein Hsp20</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CG723_10850</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CB01635</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the small heat shock protein (HSP20) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN12144.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN12144">
        <property type="protein sequence ID" value="PJN12144"/>
        <property type="gene ID" value="CG723_10850"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002068">
        <property type="entry name" value="A-crystallin/Hsp20_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008978">
        <property type="entry name" value="HSP20-like_chaperone"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00011">
        <property type="entry name" value="HSP20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49764">
        <property type="entry name" value="SSF49764"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01031">
        <property type="entry name" value="SHSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SHSP" evidence="3">
        <location>
            <begin position="45"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS01031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PJN12144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="157" mass="17157" checksum="78F68376F67420D0" modified="2018-04-25" version="1">MVERADVTRSNPARTAWWAGADPATELQHLWGEVSRLLERSSQPAGPSQHWMPVVEEADSGVAYVVRAELPGVPRERVNVEVDGREIHISGAVDETTDGNALRRRCGTFSYGVRVPGDVDIDRIEADMADGVLTLRLPKTAAVTRRTIEIRADGSEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JZ59</accession>
    <name>A0A2M9JZ59_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CG723_12075</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN12173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN12173">
        <property type="protein sequence ID" value="PJN12173"/>
        <property type="gene ID" value="CG723_12075"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd01026">
        <property type="entry name" value="TOPRIM_OLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034139">
        <property type="entry name" value="TOPRIM_OLD"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PJN12173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="216" mass="23669" checksum="FB2215C300FFC073" modified="2018-04-25" version="1">MRRFRRAAGAWAARGGDDGPAAEAARELAVVAGVRKVVLVEGESDLAAVEALARRRGRSLDEEGVAVLPLGGAMSIGRFLAVCGPDGLDVTVAGLCDAGEEHYFRSVLERTGPRPHLTHADMEQLGFYVCVADLEDELIRGLGADTVQEVLDAEGDLRSFRTFQKQPAQRDRGVERQLRRFMGTHSGRKTQYARSLVERLDLDRVPRPLDRLLAHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JZ72</accession>
    <name>A0A2M9JZ72_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Aminoglycoside phosphotransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_12435</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN12182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN12182">
        <property type="protein sequence ID" value="PJN12182"/>
        <property type="gene ID" value="CG723_12435"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="APH" evidence="1">
        <location>
            <begin position="124"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN12182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="289" mass="31092" checksum="F8C96D8527671213" modified="2018-04-25" version="1">MTGDTGPADSHELAGGMMNAGAVFRRGDVVERPAPPNVRALHAYLAALRHQGFDAAPVPVGVRADGREQLGFVPGHVAVPPFPPWAMSQTALRSVGALLRRLHEASARVAVDVSAGWSGELADPEGGTMLCHNDVCLENVVFRDGRAVALIDFDQAAPGRPVWDVAMTAGYWVPMRDPESAAPHYPVPDPSHPLDAPGRLRLLADSYGLSQRERAELPEVVEQAAAVCRAFVARRVADGDPAFVQALRDRGGWERWDRIQAWLSDGREAFRGALLEGFDTGSVRPLPPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-05-25" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JZB0</accession>
    <name>A0A2M9JZB0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">LacI family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CG723_13455</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN12209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN12209">
        <property type="protein sequence ID" value="PJN12209"/>
        <property type="gene ID" value="CG723_13455"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01392">
        <property type="entry name" value="HTH_LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000843">
        <property type="entry name" value="HTH_LacI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046335">
        <property type="entry name" value="LacI/GalR-like_sensor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00356">
        <property type="entry name" value="LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13377">
        <property type="entry name" value="Peripla_BP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00354">
        <property type="entry name" value="HTH_LACI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50932">
        <property type="entry name" value="HTH_LACI_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH lacI-type" evidence="4">
        <location>
            <begin position="2"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PJN12209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="325" mass="34437" checksum="F50D93991E7A1240" modified="2018-04-25" version="1">MATLMDVARAAGVSKATASRALQRPELVAEPTRLRVLDAAQRLGFHPNAAARALTTGRTGLVGLVVPTLSNPFFAPLVMGAQQTAEKTDRHLLIAVSEYDPTREAELADRLAEQADGLIMVTPVGTDAALRERARRVPLILVDRQVGRLPAVVADTATGLAQLMDHLLDQGHRDIAYVSGPAGSWADGQRSAILRERAEQAKARLHVLGPMPPTFDAGIEAARTLPREATAVLAYNSYLTLGLLHGLAAAHRRVPEDVSLAAADDLSSLKSTTPSVTALDVPVEEVGALAVTRLIDLLAGHHVTVTSRLPSRPVLRASTAPPANR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JZT9</accession>
    <name>A0A2M9JZT9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">MCE-family lipoprotein LprK (MCE-family lipoprotein Mce1e)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CG723_04880</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000002">
        <property type="protein sequence ID" value="PJN12386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN12386">
        <property type="protein sequence ID" value="PJN12386"/>
        <property type="gene ID" value="CG723_04880"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005693">
        <property type="entry name" value="Mce"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003399">
        <property type="entry name" value="Mce/MlaD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024516">
        <property type="entry name" value="Mce_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11887">
        <property type="entry name" value="Mce4_CUP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02470">
        <property type="entry name" value="MlaD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00996">
        <property type="entry name" value="Mtu_fam_mce"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="domain" description="MlaD" evidence="3">
        <location>
            <begin position="59"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="domain" description="Mce4_CUP1" evidence="4">
        <location>
            <begin position="148"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="356"/>
            <end position="413"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF11887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PJN12386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="413" mass="42224" checksum="92B8EAE2FA4AEABA" modified="2018-04-25" version="1">MRGFRTGSAVGAAGVGLGGLLAVGLGFALAFGAFSVTAPKFDGIEDLPLPGGADLGSHPYTVRAELADVLSLVPQSAVKVNDVAVGRVTDIRLGGNDWTARVTMKINGDVRLPADTTARLEQSSLLGEKYIQLIAPKEVASAPAGGSGSTLADGVTIPLARTSRNTEVEEVFGALSLLLNGGGVNQLKTITKELNAAIGGREPQVRSMLKRVNKLVTSLDDHRGDITDALDGVNKLSATLATRKQDVGAVLTDLSPGLKTLEEQRGSLLTMLRSLDRLSTVAVSTIDQGKEDMVADLKALAPTLKSLADAGEDLPDSLQVLLTYPFTDEVLRGVKGDYLNTYLDVVAAPGTQVIPPLVPSGTPSGSPSPSPAKAAPGKAGSDKKGGKGGSDAPLPLPSVPSTPSASASGSEAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JZZ2</accession>
    <name>A0A2M9JZZ2_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 6">Deferrochelatase</fullName>
            <ecNumber evidence="6">1.11.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Peroxidase EfeB</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CG723_05290</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CB01635</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Involved in the recovery of exogenous heme iron. Extracts iron from heme while preserving the protoporphyrin ring intact.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>2 H(+) + heme b = Fe(2+) + protoporphyrin IX</text>
            <dbReference type="Rhea" id="RHEA:22584"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:57306"/>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
            <dbReference type="EC" id="4.99.1.1"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="4">
            <dbReference type="Rhea" id="RHEA:22585"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </cofactor>
        <text evidence="6">Binds 1 heme b (iron(II)-protoporphyrin IX) group non-covalently per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 6">Belongs to the DyP-type peroxidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.11.1.-" evidence="6"/>
    <dbReference type="EMBL" id="NNBL01000002">
        <property type="protein sequence ID" value="PJN12453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN12453">
        <property type="protein sequence ID" value="PJN12453"/>
        <property type="gene ID" value="CG723_05290"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004601">
        <property type="term" value="F:peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033212">
        <property type="term" value="P:iron import into cell"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006314">
        <property type="entry name" value="Dyp_peroxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006313">
        <property type="entry name" value="EfeB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04261">
        <property type="entry name" value="Dyp_perox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01413">
        <property type="entry name" value="Dyp_perox_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01412">
        <property type="entry name" value="tat_substr_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51404">
        <property type="entry name" value="DYP_PEROXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0349">Heme</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="1 6 8" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00025737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00033706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00033771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU365017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PJN12453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="427" mass="45633" checksum="C98D3B42A39DA63A" modified="2018-04-25" version="1">MTDTTADVSVGSDNSPTPSRRSLLAVGGAGLALGAAAAGGAVAVTRTGDDPQPVADSGGAVSFHGAHQAGIATAVQDRLHFASFDVKTDDRDEFVQLLKDWTKAASRMTEGHAVGEGAYGGLPEAPPDDTGEALGLKPSRLTLTIGFGPSLFEKFGLTDRRPEALVDLPKFPGDNLDKARSNGDLCIQACADDPQIAVHAIRNLARIGFGKVAIRWSQLGFGKTSSTTPDAQTPRNLMGFKDGTRNIAGTETARLDQHVWVGAKDTDANSAWMTGGSYLVARRIRMNIETWDRTSLQEQEDVFGRDKGEGAPVGKAKERDEPFLKAMKPDAHVRLAHPDSNAGATILRRGYSFTDGTDGLGRLEAGLFFLAYQKDVRKGFVRVQRNLSRSDALNEYIQHVGSAVFAVPPGVRDSGDWWGRALFSKEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-05-25" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K0D7</accession>
    <name>A0A2M9K0D7_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8 19">Adenosylcobinamide-GDP ribazoletransferase</fullName>
            <ecNumber evidence="7 19">2.7.8.26</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="18 19">Cobalamin synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="17 19">Cobalamin-5'-phosphate synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="primary">cobS</name>
        <name evidence="20" type="ORF">CG723_05770</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">CB01635</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="16 19">Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 19">
            <text>adenosylcob(III)inamide-GDP + alpha-ribazole 5'-phosphate = adenosylcob(III)alamin 5'-phosphate + GMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23560"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57918"/>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
            <dbReference type="ChEBI" id="CHEBI:60487"/>
            <dbReference type="ChEBI" id="CHEBI:60493"/>
            <dbReference type="EC" id="2.7.8.26"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 19">
            <text>adenosylcob(III)inamide-GDP + alpha-ribazole = adenosylcob(III)alamin + GMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16049"/>
            <dbReference type="ChEBI" id="CHEBI:10329"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:18408"/>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
            <dbReference type="ChEBI" id="CHEBI:60487"/>
            <dbReference type="EC" id="2.7.8.26"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3 19">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="5 19">Cofactor biosynthesis; adenosylcobalamin biosynthesis; adenosylcobalamin from cob(II)yrinate a,c-diamide: step 7/7.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="19">Cell membrane</location>
            <topology evidence="19">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6 19">Belongs to the CobS family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.8.26" evidence="7 19"/>
    <dbReference type="EMBL" id="NNBL01000002">
        <property type="protein sequence ID" value="PJN12540.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN12540">
        <property type="protein sequence ID" value="PJN12540"/>
        <property type="gene ID" value="CG723_05770"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00148">
        <property type="reaction ID" value="UER00238"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051073">
        <property type="term" value="F:adenosylcobinamide-GDP ribazoletransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008818">
        <property type="term" value="F:cobalamin 5'-phosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009236">
        <property type="term" value="P:cobalamin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00719">
        <property type="entry name" value="CobS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003805">
        <property type="entry name" value="CobS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34148">
        <property type="entry name" value="PTHR34148"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02654">
        <property type="entry name" value="CobS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 19" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10 19" id="KW-0169">Cobalamin biosynthesis</keyword>
    <keyword evidence="13 19" id="KW-0460">Magnesium</keyword>
    <keyword evidence="15 19" id="KW-0472">Membrane</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11 19 20" id="KW-0808">Transferase</keyword>
    <keyword evidence="12 19" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="14 19" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="33"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="114"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="141"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="180"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00010561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00013200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00015850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00025228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00032605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00032853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="PJN12540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="260" mass="25264" checksum="8CFE9C4F1136E6FA" modified="2018-04-25" version="1">MPATPADGLRFAFGTLTVLPVKVTRWDRDAARAGMLCAPVAGLVVGLAAAALGGLLTLLGAGPLLAAVASVSVPAALTRGLHLDGLADTADGLGSGKPAEDALRIMKQSDIGPFGVITLVLALLAQVAALAELYADSWARGALAAVVSALTARLALTLASRTGVPPARPEGLGAAVAGTVPVRGALLAAAVTVCAAGAAGAVTGSAYGAVRGAAAAVLACCAAELLLRHCVRRFGGVTGDVFGGVAETTATAALVVLTFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K0R7</accession>
    <name>A0A2M9K0R7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Monooxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_06745</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000002">
        <property type="protein sequence ID" value="PJN12709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN12709">
        <property type="protein sequence ID" value="PJN12709"/>
        <property type="gene ID" value="CG723_06745"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016646">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002563">
        <property type="entry name" value="Flavin_Rdtase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01613">
        <property type="entry name" value="Flavin_Reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00903">
        <property type="entry name" value="Flavin_Reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flavin_Reduct" evidence="1">
        <location>
            <begin position="13"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN12709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="162" mass="17236" checksum="A2454DDE6A351F53" modified="2018-04-25" version="1">MERLTPDAFRDVLGHFASGVTVVAALDEDTGEPVGLACQSFASLSLEPPLVLLCVAKSSTSWPRVRRAGRFGVSILADDQRAVCAAVGRSGPDKFRDVRWEPTGGGAVRVEGALATVDCELYAVHEAGDHWIVTARVLAVTARDGGNPLLYFRSAYATGEFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K197</accession>
    <name>A0A2M9K197_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Enoyl-CoA hydratase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_07785</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the enoyl-CoA hydratase/isomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000002">
        <property type="protein sequence ID" value="PJN12898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN12898">
        <property type="protein sequence ID" value="PJN12898"/>
        <property type="gene ID" value="CG723_07785"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018376">
        <property type="entry name" value="Enoyl-CoA_hyd/isom_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00166">
        <property type="entry name" value="ENOYL_COA_HYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN12898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="270" mass="28406" checksum="E9A7D739435358CE" modified="2018-04-25" version="1">MASPDSGSGSLAPVLDKDGVRLTVDGSIATVTLANPDKRNAQSPALWRALADAGKSLPGSVRVVVLRAEGLSFSAGLDRQAFTPEGFDGEPSFIDLARGSDDVLDDTIAEYQEAFTWWRRSDLITVAAVQGHAIGAGFQLALACDLRIAAEDVQFSMRETSLGLVPDLTGTHPLVSLVGYARALEICVTGRYVHADEAGRIGLANLVVPADQLDAAARDLAGALIAAPRDAVIETKALLQGVSGRSYEEQRTAERAAQGRRLRDLAGLGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K1D2</accession>
    <name>A0A2M9K1D2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_07980</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000002">
        <property type="protein sequence ID" value="PJN12934.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN12934">
        <property type="protein sequence ID" value="PJN12934"/>
        <property type="gene ID" value="CG723_07980"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="16"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN12934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="39" mass="4014" checksum="AA51B8A08FF08D43" modified="2018-04-25" version="1">MSPVLDPNPQNGQKKLLIVLGSMLAITVIIAVIASIASP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-05-25" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K1E7</accession>
    <name>A0A2M9K1E7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_04080</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000002">
        <property type="protein sequence ID" value="PJN12952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN12952">
        <property type="protein sequence ID" value="PJN12952"/>
        <property type="gene ID" value="CG723_04080"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004573">
        <property type="term" value="F:Glc3Man9GlcNAc2 oligosaccharide glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009311">
        <property type="term" value="P:oligosaccharide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004888">
        <property type="entry name" value="Glycoside_hydrolase_63"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10412">
        <property type="entry name" value="PTHR10412"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="SSF48208"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="297"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN12952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="461" mass="50603" checksum="93D024F48EFCB468" modified="2018-04-25" version="1">MREQAARVLETNWTGTSTVPSRTLYPHQWSWDSAFVAIGSRHVSPLRAQLELETLFDAQWGDGRVPHIVFNPSVPLDAYFPSPDFWRSSTSGRAAGAPRSVQTSGIVQPPVHALAAWLVHRADPGLSRSRSFLARVYPKLAAWHRYLLHRRDLGGGGLASVIHPWEQGMDNSPCWDAPLSRIAPAPARAFRRADLEHGAPDDRPTDLDYGRYVRLATDYRNGQYADGQGEFAVEDPSFNALLIASEHALARIACELGAAGTARHARAERLTAALVERLWDPVTGMFFCRDLRGAADGHHAPRAPGHDTPRTAGRSSPPALIPEYGVSGLIPLILPTLPRHVTAGLLRVARGPRFGLGTAVRLVPSYDLTGPAFDPHRYWRGPAWFNTNWLIERGLRLHGEHAEAERLRAALLGTALDTAFAEYVDPYTGRGCGARGFAWSAALALDLLQEPLERHEGGTWG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K1F0</accession>
    <name>A0A2M9K1F0_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RNA polymerase sigma factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CG723_04215</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CB01635</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the sigma-70 factor family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000002">
        <property type="protein sequence ID" value="PJN12956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN12956">
        <property type="protein sequence ID" value="PJN12956"/>
        <property type="gene ID" value="CG723_04215"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000943">
        <property type="entry name" value="RNA_pol_sigma70"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009042">
        <property type="entry name" value="RNA_pol_sigma70_r1_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007624">
        <property type="entry name" value="RNA_pol_sigma70_r3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007630">
        <property type="entry name" value="RNA_pol_sigma70_r4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00140">
        <property type="entry name" value="Sigma70_r1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04539">
        <property type="entry name" value="Sigma70_r3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04545">
        <property type="entry name" value="Sigma70_r4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00046">
        <property type="entry name" value="SIGMA70FCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00715">
        <property type="entry name" value="SIGMA70_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00716">
        <property type="entry name" value="SIGMA70_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0731">Sigma factor</keyword>
    <keyword evidence="4 5" id="KW-0804">Transcription</keyword>
    <keyword evidence="1 5" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="RNA_pol_sigma70" evidence="7">
        <location>
            <begin position="258"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="domain" description="RNA_pol_sigma70" evidence="8">
        <location>
            <begin position="427"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="58"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="149"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS00715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS00716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PJN12956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="467" mass="50813" checksum="765182AF141AB160" modified="2018-04-25" version="1">MPESSERGRNPDNGSDTPAVPPIAYGTDSGVAAVADPGVPLPHASAAITLEVAPVQTQTLSQTGAARQSAQGAPAPDTDGEALPAVPQQRGPENHPDSDPPDDPADAPLTSGAAELPEPEPEPGPESETEPREAGPRPPVALLLDTVEAETPEPPASRSRTDTGGPSSDLFRQYLREIGRIPLLTAAEEVDLARKVEAGLFAEEKLTGTPDPDSQLAIDLDKLVVMGRMAKRRLIEANLRLVVSVAKRYVGRGLTMLDLVQEGNLGLIRAVEKFDYARGYKFSTYATWWIRQAMSRALADQARTIRVPVHVVELINRVVRVQRRMLQERGYEPTPEEVAAHLELAPERVSEVLRLAQEPVSLHAPVGEEDDVALGDLIEDGDATSPVESAAFLLLRQHLEAVLSTLGERERKVVQLRYGLADGRPRTLEEIGRIFGVTRERIRQIESKTLNKLRDHAFADQLRGYLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-09-29" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K1N2</accession>
    <name>A0A2M9K1N2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CG723_05185</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000002">
        <property type="protein sequence ID" value="PJN12980.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN12980">
        <property type="protein sequence ID" value="PJN12980"/>
        <property type="gene ID" value="CG723_05185"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015057">
        <property type="entry name" value="Rv2632c-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038070">
        <property type="entry name" value="Rv2632c-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08962">
        <property type="entry name" value="DUF1876"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143212">
        <property type="entry name" value="SSF143212"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PJN12980.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="91" mass="10002" checksum="1186DCCEA6E90E81" modified="2018-04-25" version="1">MSAQTAVGWHVELEFEEDTHRTRAAALVRLPDGSEVRAHGYASRHPSDANQPRVGEEVAGARALNELAMKMLTKAHDEIDEASGRTSHTLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K1N6</accession>
    <name>A0A2M9K1N6_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HTH_58 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_07780</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000002">
        <property type="protein sequence ID" value="PJN13029.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN13029">
        <property type="protein sequence ID" value="PJN13029"/>
        <property type="gene ID" value="CG723_07780"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045745">
        <property type="entry name" value="HTH_58_Actinobacteria-type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19575">
        <property type="entry name" value="HTH_58"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH_58" evidence="2">
        <location>
            <begin position="13"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF19575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN13029.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="87" mass="9262" checksum="28335B372D03961A" modified="2018-04-25" version="1">MRSPERTSHEEARVAETLKKGSRVTGAARDKLAADLKKKYDSGASIRALAEETGRSYGFVHRMLSESGVTLRGRGGATRGKKATAAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K1Q5</accession>
    <name>A0A2M9K1Q5_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 7 8">Protein RecA</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6 7 8">Recombinase A</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7 13" type="primary">recA</name>
        <name evidence="13" type="ORF">CG723_00145</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">CB01635</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7 9">Belongs to the RecA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000001">
        <property type="protein sequence ID" value="PJN13056.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN13056">
        <property type="protein sequence ID" value="PJN13056"/>
        <property type="gene ID" value="CG723_00145"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009432">
        <property type="term" value="P:SOS response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00983">
        <property type="entry name" value="recA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00268">
        <property type="entry name" value="RecA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013765">
        <property type="entry name" value="DNA_recomb/repair_RecA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020584">
        <property type="entry name" value="DNA_recomb/repair_RecA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020588">
        <property type="entry name" value="RecA_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023400">
        <property type="entry name" value="RecA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020587">
        <property type="entry name" value="RecA_monomer-monomer_interface"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45900">
        <property type="entry name" value="PTHR45900"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00154">
        <property type="entry name" value="RecA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00142">
        <property type="entry name" value="RECA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54752">
        <property type="entry name" value="SSF54752"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02012">
        <property type="entry name" value="tigrfam_recA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00321">
        <property type="entry name" value="RECA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50162">
        <property type="entry name" value="RECA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50163">
        <property type="entry name" value="RECA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 9" id="KW-0227">DNA damage</keyword>
    <keyword evidence="7 9" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="7 8" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5 7 9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 7 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 8" id="KW-0742">SOS response</keyword>
    <feature type="domain" description="RECA_2" evidence="11">
        <location>
            <begin position="36"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="domain" description="RECA_3" evidence="12">
        <location>
            <begin position="200"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="327"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="66"/>
            <end position="73"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00015553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00033319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000526"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PJN13056.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="374" mass="39594" checksum="520F81FA155357AD" modified="2018-04-25" version="1">MAGTDREKALDAALAQIERQFGKGAVMRMGERPNEPIEVIPTGSTALDVALGVGGLPRGRVVEVYGPESSGKTTLTLHAVANAQKAGGSVAFIDAEHALDPEYAKKLGVDIDNLILSQPDNGEQALEIVDMLVRSGALDLIVIDSVAALVPRAEIEGEMGDSHVGLQARLMSQALRKITSALNQSKTTAIFINQLREKIGVMFGSPETTTGGRALKFYASVRLDIRRIETLKDGTDAVGNRTRVKVVKNKVAPPFKQAEFDILYGQGISREGGLIDMGVENGFVRKAGAWYTYEGDQLGQGKENARNFLRDNPDLANEIEKKIKEKLGVGVKPEAPTAEPGADAAGATPAEDAAKTVPAPAAKATKSKAAAVKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K2E1</accession>
    <name>A0A2M9K2E1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_01620</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000001">
        <property type="protein sequence ID" value="PJN13304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN13304">
        <property type="protein sequence ID" value="PJN13304"/>
        <property type="gene ID" value="CG723_01620"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="99"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN13304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="130" mass="13716" checksum="5CCB541C2383ED7B" modified="2018-04-25" version="1">MGGCSASRQWRQAERIDAAPVRVSGVVTAVEHVPKSGYEQVIAYEVQGHRHTVTRALGTGPGSPGVGHRVCLEADRDHPGVVRLCGERYPSGDDLYPTYVLVAVAGAIGTCVVAGVAAGVRRRSRSKPAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K2E3</accession>
    <name>A0A2M9K2E3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Glycosyl transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CG723_01590</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CB01635</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the UDP-glycosyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000001">
        <property type="protein sequence ID" value="PJN13298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN13298">
        <property type="protein sequence ID" value="PJN13298"/>
        <property type="gene ID" value="CG723_01590"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016758">
        <property type="term" value="F:hexosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008194">
        <property type="term" value="F:UDP-glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03784">
        <property type="entry name" value="GT1_Gtf-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002213">
        <property type="entry name" value="UDP_glucos_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035595">
        <property type="entry name" value="UDP_glycos_trans_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006326">
        <property type="entry name" value="UDPGT_MGT-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00201">
        <property type="entry name" value="UDPGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01426">
        <property type="entry name" value="MGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00375">
        <property type="entry name" value="UDPGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="UDPGT" evidence="3">
        <location>
            <begin position="305"/>
            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS00375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PJN13298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="420" mass="45997" checksum="E722E61AFAED6F5F" modified="2018-04-25" version="1">MCRNKLHETSRLTYGGVMTVPRNAHIAMFSIAAHGHVNPSIEVIRELVARGHRVTYAIPSQFAEKVAEAGAEPKIWHSTLPTDDDPDAWGTELVDNLEPFLTDAIQALPQLVDLYEDDEPDLVLYDITAYPARVLAHRWNVPIVQFSPNLVAWEGYEEEVGKPMFEPLKQTPRGKAFYENFESWIRSNGIDLSVEDFMGRPDRCLVLIPKALQPNADRVDESRYTFVGACQGERAAQGEWQRPAGAEKVLLVSLGSSFTKQPAFYRACVGAFGDLPGWHVVLQIGKFVDEGELGEIPANVEVHHWVPQLAILGQADAFITHAGAGGSQEGLATATPMVAVPQAVDQFGNADMLQGLGVARHVPMEEATPENLKRAVLAMASDPEVARRLQEIRAGMAGEGGTQRAADLVERVGDLVPREA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K2I5</accession>
    <name>A0A2M9K2I5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">AraC family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_01785</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000001">
        <property type="protein sequence ID" value="PJN13336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN13336">
        <property type="protein sequence ID" value="PJN13336"/>
        <property type="gene ID" value="CG723_01785"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018062">
        <property type="entry name" value="HTH_AraC-typ_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00041">
        <property type="entry name" value="HTH_ARAC_FAMILY_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="2">
        <location>
            <begin position="135"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN13336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="230" mass="24331" checksum="6AF447E5ED6ED030" modified="2018-04-25" version="1">MYRERAAPSVAGAVLWTRTVTPDGDGRSPGPDVLPDGCMDLLWTEGRLFVAGPDTHAYRPGISGATRFAGIRFFPGTAPAVLGVPAQELRDRRVDLADLWPSDQVRRLTERVDAAQDPAAALETVVLERGAAPPDPVLAHIVASLRAGRSVAETADSAGLGARSLHRRSLAAFGYGPKTLARVLRLQRALALARGGVPLAETAARAGYADQAHLARDVRELAGVPPTRLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K2M1</accession>
    <name>A0A2M9K2M1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_01985</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000001">
        <property type="protein sequence ID" value="PJN13372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN13372">
        <property type="protein sequence ID" value="PJN13372"/>
        <property type="gene ID" value="CG723_01985"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002397">
        <property type="entry name" value="Cyt_P450_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00359">
        <property type="entry name" value="BP450"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="SSF48264"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0349">Heme</keyword>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN13372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="404" mass="44073" checksum="7E3547858A7C40F0" modified="2018-04-25" version="1">MAHDPHVIDPAGRGLHAEADLLRTRGTAALVELPGGIRAWAPTRYTILKQLLADDRVSKDPNQHWPAWINGEFRETWVNSWVGVTNMFTAYGSNHRRLRKLISPAFTKRRTDGLRPRIEELTAGLLDRMAGAPDGRVDLRAAYAHPLPMQVICELFGLPEDRQADAARLIAGIMDTTVTPEQAMAIWQEVQELLGGLVALKRETPADDLTSVLITTRDDEDGSGLTEQELIDTLLLVIGAGHETTVNLIGNAVQALLSHPDQLARVLAGEIPWNDVIEETLRWAPSIANLPLRYAVEDIELPDGVKIPQGDAILATYASAGRDPLRHGEDAGSFDVARVDKEHLAFGYGVHYCVGAPLARLEAAIALPALFERFPALALDASEGAAPHVESFIGYGYGELRVTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-09-29" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K2R6</accession>
    <name>A0A2M9K2R6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_02250</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000001">
        <property type="protein sequence ID" value="PJN13418.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN13418">
        <property type="protein sequence ID" value="PJN13418"/>
        <property type="gene ID" value="CG723_02250"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002577">
        <property type="entry name" value="HTH_HxlR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003033">
        <property type="entry name" value="SCP2_sterol-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036527">
        <property type="entry name" value="SCP2_sterol-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01638">
        <property type="entry name" value="HxlR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02036">
        <property type="entry name" value="SCP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55718">
        <property type="entry name" value="SSF55718"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51118">
        <property type="entry name" value="HTH_HXLR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH hxlR-type" evidence="1">
        <location>
            <begin position="10"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN13418.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="212" mass="22750" checksum="98BF81BB0B6DE44F" modified="2018-04-25" version="1">MPRRSYDQYCAAARALDAVGDRWTLLIVRELLAGPRRYTDLHADLPGVSTDVLASRLKDMEREGVAERRRLPAPVSAYVYELTPRGRQLLPVLQALGEWGAPALEERGPTDAVRAHWFALPLLSHLERLGGEGVVEVRLDEGEFHVRVGGSGAGGPVYAEGPVDGEPDARLVLGTETCVAVVRGGLTLEEAARAGRVAVSGDGALAKALREV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-05-25" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K2T6</accession>
    <name>A0A2M9K2T6_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Probable allantoicase</fullName>
            <ecNumber evidence="3">3.5.3.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Allantoate amidinohydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3 5" type="primary">alc</name>
        <name evidence="5" type="ORF">CG723_02330</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CB01635</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>allantoate + H2O = (S)-ureidoglycolate + urea</text>
            <dbReference type="Rhea" id="RHEA:11016"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16199"/>
            <dbReference type="ChEBI" id="CHEBI:17536"/>
            <dbReference type="ChEBI" id="CHEBI:57296"/>
            <dbReference type="EC" id="3.5.3.4"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Nitrogen metabolism; (S)-allantoin degradation; (S)-ureidoglycolate from allantoate (aminidohydrolase route): step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the allantoicase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.3.4" evidence="3"/>
    <dbReference type="EMBL" id="NNBL01000001">
        <property type="protein sequence ID" value="PJN13431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN13431">
        <property type="protein sequence ID" value="PJN13431"/>
        <property type="gene ID" value="CG723_02330"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00395">
        <property type="reaction ID" value="UER00654"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004037">
        <property type="term" value="F:allantoicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000256">
        <property type="term" value="P:allantoin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006144">
        <property type="term" value="P:purine nucleobase metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00813">
        <property type="entry name" value="Allantoicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005164">
        <property type="entry name" value="Allantoicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015908">
        <property type="entry name" value="Allantoicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12045">
        <property type="entry name" value="PTHR12045"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03561">
        <property type="entry name" value="Allantoicase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016516">
        <property type="entry name" value="Allantoicase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="SSF49785"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02961">
        <property type="entry name" value="allantoicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 3" id="KW-0659">Purine metabolism</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Allantoicase" evidence="4">
        <location>
            <begin position="42"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="domain" description="Allantoicase" evidence="4">
        <location>
            <begin position="224"/>
            <end position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF03561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PJN13431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="371" mass="40556" checksum="9BDBCA55D41B20C9" modified="2018-04-25" version="1">MTAIPSFTGDANPYGGGDPYADYRTADFPFTQYADLAARQLGAGVIAANDEFFAQRENLLVPERAEFDPEHFGHKGKIMDGWETRRRRGTGADHPWPTAEDHDWALVRLGAPGVIRGIIVDTAHFRGNYPQAVSVEAASVEGAPTPEELLSGDVKWTTLVPRTAVGGHAANGFAVDVEQRFTHLRVNQHPDGGIARLRVHGEVVPDPKWLATLGTFDVVALENGGRAEDASNLFYSPASNTIQPGRSRKMDDGWETRRRRDQGNDWISYGLAAQSQIRALEIDTAYLKGNSAGWASVSVRDGDDGEWVEVLPRTRLQPDTNHRFVLDAPAVGTHARVDIYPDGGISRLRLFGSLTDEGTARLTARHQELGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K2U7</accession>
    <name>A0A2M9K2U7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_02445</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000001">
        <property type="protein sequence ID" value="PJN13449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN13449">
        <property type="protein sequence ID" value="PJN13449"/>
        <property type="gene ID" value="CG723_02445"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.850">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000868">
        <property type="entry name" value="Isochorismatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036380">
        <property type="entry name" value="Isochorismatase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00857">
        <property type="entry name" value="Isochorismatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52499">
        <property type="entry name" value="SSF52499"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Isochorismatase" evidence="1">
        <location>
            <begin position="10"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN13449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="190" mass="20145" checksum="84B21B4596AD4419" modified="2018-04-25" version="1">MPATTLDERTALVLIDLQNGILGLPTVHPADGVLKNGATLADAFRAKGLPVVRVRVAWSPDGGDLPVSRSAAPGLTQAPPAAFSEFPDELGPLGDDIVITKRHWGAFTGTELDLQLRRRGVTQIVLAGISSSIGVESTARSAFELSYHLTVVEDATTDTDAASHEHSFGKIFPRIAELATTEEIVELLGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K322</accession>
    <name>A0A2M9K322_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ABC transporter substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_02310</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000001">
        <property type="protein sequence ID" value="PJN13427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN13427">
        <property type="protein sequence ID" value="PJN13427"/>
        <property type="gene ID" value="CG723_02310"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="239"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="288"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="323"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN13427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="358" mass="36128" checksum="75F6EEF57854D774" modified="2018-04-25" version="1">MFVAWRDLRFAKGRFALMGSVVVLITLLVGLLSALTAGLARDNTSALTGLPADHLAFARPADGQAVSFTGSTVGAGQWRALAARPGIESAQPIGISTVNAEAGHHTAAVSAFGVRPRSGLAPDTTAPGTAVLSQQAADDLGAGPGDRIALSSTSLTVSAVVGDASYSHTPVVWIDLGDWQNVAPGGQRTGERATVIALRTGDGADLGAADRAAGTETRTVAGALEAIGSYQAENGSLQLMRGFLFVISAMVIGAFFTVWTIQRSGDIAVLKALGSSTPYLLKDALGQAVVMLVGGTALGTALAALIGAFVPDSVPFVMEPLTTLSPAAVMTVLGAGGAALSIRRITAVDPLTALGSAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K3I2</accession>
    <name>A0A2M9K3I2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Dynein regulation protein LC7</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_03875</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000001">
        <property type="protein sequence ID" value="PJN13688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN13688">
        <property type="protein sequence ID" value="PJN13688"/>
        <property type="gene ID" value="CG723_03875"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004942">
        <property type="entry name" value="Roadblock/LAMTOR2_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03259">
        <property type="entry name" value="Robl_LC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00960">
        <property type="entry name" value="Robl_LC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Robl_LC7" evidence="1">
        <location>
            <begin position="14"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN13688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="144" mass="15023" checksum="B8D1C7C347C61C46" modified="2018-04-25" version="1">MASDVPTGHVSDLDWLMSGLVQRVPHTRSAVLLSSDGLVKSVHGLDADSADHMAALASGLYSLGRSAGVRFGDGGEVRQVVVELDSTLLFVSTAGSGTCLAVLAGREADAAVLGYEMAMLVKSVRPYLMTAPRQHAAEPTAMRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JEK3</accession>
    <name>A0A2M9JEK3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Short-chain dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CG723_45445</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000054">
        <property type="protein sequence ID" value="PJN05324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN05324">
        <property type="protein sequence ID" value="PJN05324"/>
        <property type="gene ID" value="CG723_45445"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PJN05324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="257" mass="26905" checksum="98D2ED8F036BD965" modified="2018-04-25" version="1">MPITHDSLDGLRVLVTGGSRGLGAATVRRFVAAGASVLTASRRRPEEDSGARFIAADLSTQQGVAELGRRVVEQVGGVAALVNNAGAASAPAPTLSRSDASWQADLEMNLLSAVRLDRALVPGMVERGSGVVVHVSSIASQLPQRTEASYAAAKAALNTYSRELATEVGEHGVRVVCVLPGFVVTDGATAHLKYMAEKQGITTEEVTQQIVDHLKVPMGRPGDPEDVAEMIAFLASDRAKWLTGAQFRVDGGIIPTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JEP5</accession>
    <name>A0A2M9JEP5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CG723_45160</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000051">
        <property type="protein sequence ID" value="PJN05361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN05361">
        <property type="protein sequence ID" value="PJN05361"/>
        <property type="gene ID" value="CG723_45160"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PJN05361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="86" mass="9299" checksum="09281360545DDF5E" modified="2018-04-25" version="1">MRRGQEFLIYAAHTTGLTRLFQNAAGTIGVCSAPGGSRCFHCEGTGGWPGQCGYSPLWRRDDVGRGGFIAWGRMRTARFSQQTSGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JF98</accession>
    <name>A0A2M9JF98_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="10">NADP oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CG723_44370</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CB01635</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ferredoxin--NADP reductase type 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000047">
        <property type="protein sequence ID" value="PJN05483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN05483">
        <property type="protein sequence ID" value="PJN05483"/>
        <property type="gene ID" value="CG723_44370"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021163">
        <property type="entry name" value="Ferredox_Rdtase_adrenod"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000362">
        <property type="entry name" value="FNR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5 8" id="KW-0521">NADP</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyr_redox_2" evidence="9">
        <location>
            <begin position="6"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="16"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="38"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="46"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="82"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="197"/>
            <end position="198"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="209"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="352"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="359"/>
            <end position="361"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="359"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000362-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000362-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PJN05483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="444" mass="48003" checksum="FD91AEE60BE79503" modified="2018-04-25" version="1">MNGAAFRVAVIGSGPSGAYAAQELSEQTDLDVSVDVYERLPVPFGLVRYGVAPDHQRIKSIVGLLADIFAHPRVRFLGNVQVGTDITVAELRQHYDAVVVACGASADRSLSIPGEDLPGVCSATDFVSWYSGHPDAAVDRFALTAEKAVVIGLGNVALDVARMLCRTPEELRRTDVPEHVVDVLANSSIREIVILGRRGPAYAKFSNKELGEFGELSEVRVQVDSGDLADDEDALHRAQENPLTRRMLATLRGYADSGPQGDRRTVRFAFSRTPVAFVGDDSVSGLEVVHQRPATTAVEELIPAGFFVRSVGYRGLGVHGLPLDPRSGTIPHSEGRVVDGTEVLDGVYVTGWIKRGPSGVIGTNKQDAALTAAAILEDRKRATRPPQKTVVDPMDLLKERRVELVEWPAWQRIDAAEEAEGRPVGRARVKLHERSRMLAAASAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JFI9</accession>
    <name>A0A2M9JFI9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cell division protein FtsK</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_43340</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000043">
        <property type="protein sequence ID" value="PJN05649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN05649">
        <property type="protein sequence ID" value="PJN05649"/>
        <property type="gene ID" value="CG723_43340"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3" id="KW-0132">Cell division</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="171"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN05649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="722" mass="78635" checksum="698417A16D6E5CB7" modified="2018-04-25" version="1">MSENTVTGQPEEPERAGAEVFDITTGLPAAPAPDPAPAEPSEPAVPIEADDDEDESPRPRPVDSPDLPAPGITTYKRKPILPSWLTSKPGFVSTTQRAAGNAFYAAVFHGIRTPWYALQLGLHAPRGAARMVRNTNRWVWDAEAAPLRAYEVYKENTAEYLKLSRQRDHRVRLRVLVTTVGLIFGTGFALTMYVMAPGWLTVLASAAVLVAGFWGAPQDQPVIGPAVLKTEIQKLTGSIVLRALDNIGNAKLSAAIKKGADMNGMRFTSEITRDGPGYRADLDLPWGVTPEDIMEARKPLASGLRRKVGCVWPSADPTEHEGRLILWVGDKPMNETTKPAWPLLKSGSVDLFKPVVFGNDQRMGDVSVTLMFASVIVGSIPRMGKTFLMRLFLLIAALDPRAELYAFDFKGTGDFGALEPVCHRYRAGDEDEDILYVLESLRELRTELRRRAKVIKSLPRSRCPESKVTAELANDKSLGLHPIVAGFDECQVPFEHEKYGAEIEEICTDLGKRGPALGMTMLFGTQRPDAKSLPTGISANAVLRFCLKVMGQPANDMVLGTSMYKAGYRATMFSRTDRGICWMAGEGDDPRIVASAFVDALGAEQVVGRARAMREEYGNVTGHAIGQAPESGEATFDLLADILKVVPADEDKVWNEKVAARLATLRPDVYGGWKGETVTSNLKPHGVAAQDVWGTSDKGKGTTRRGIARADITKAITVRDGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JFQ5</accession>
    <name>A0A2M9JFQ5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Phosphonomutase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CG723_43405</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000043">
        <property type="protein sequence ID" value="PJN05662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN05662">
        <property type="protein sequence ID" value="PJN05662"/>
        <property type="gene ID" value="CG723_43405"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00377">
        <property type="entry name" value="ICL_PEPM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039556">
        <property type="entry name" value="ICL/PEPM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_Kinase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040442">
        <property type="entry name" value="Pyrv_Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="SSF51621"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PJN05662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="274" mass="27662" checksum="D33E6E0C098EE4CC" modified="2018-04-25" version="1">MNQPACAAFEALHHDPGGPLLLPNAWDHASAAALAGQGFTAIGTTSLGVAAAAGLPDGAAATREETLRLARRLGGDAFLLSVDAEGGFGDDPAEVAGLARELAQAGAVGINLEDGRADGTLTPAPVHAAKIAAVKAAVPDLFVNARTDTYWLPDPRTAPEPETRRRLDAYRQAGADGVFVPGLTDPAAITALVAHLRPSGIPLNILYSPTGPTVPELAALGVRRVSLGSLLFRAALGAAVTAALGVRAGRDVAPVAPTYGEVQELSGGGDATQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JG74</accession>
    <name>A0A2M9JG74_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_42390</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000039">
        <property type="protein sequence ID" value="PJN05886.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN05886">
        <property type="protein sequence ID" value="PJN05886"/>
        <property type="gene ID" value="CG723_42390"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008884">
        <property type="entry name" value="TylF_MeTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40036">
        <property type="entry name" value="PTHR40036"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05711">
        <property type="entry name" value="TylF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="26"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN05886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="273" mass="30540" checksum="34440A778CFE1806" modified="2018-04-25" version="1">MAWRSAVNGVIKHIGYQLTRVPVPAPRQAARASEPAASAPRPTPKPKGLVLPEDYDDEAKAIIRAVKPYTMTSPERLNAFILATRHIVRHNIPGDIVECGVWRGGSMQACAKTLLSQGDTERGLYLFDTYEGMTPPTEEDLRRDGKSAEELLAAQGKDRPIWAVATLDDVKSGFQDVPYPADRLHFVQGRVEDTVPRQAPEQISILRLDTDWYASTKHELDHLYDRLVPGGVLLIDDYGYWQGSRQAVDEFLEKTGERLLLLRMDEGRIAVKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-09-29" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JG85</accession>
    <name>A0A2M9JG85_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Peptidoglycan-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CG723_42800</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CB01635</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the transglycosylase family. Rpf subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000041">
        <property type="protein sequence ID" value="PJN05767.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN05767">
        <property type="protein sequence ID" value="PJN05767"/>
        <property type="gene ID" value="CG723_42800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00118">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13925">
        <property type="entry name" value="RPF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.350.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018392">
        <property type="entry name" value="LysM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036779">
        <property type="entry name" value="LysM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023346">
        <property type="entry name" value="Lysozyme-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010618">
        <property type="entry name" value="RPF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01476">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06737">
        <property type="entry name" value="Transglycosylas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00257">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53955">
        <property type="entry name" value="SSF53955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54106">
        <property type="entry name" value="SSF54106"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51782">
        <property type="entry name" value="LYSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014876955" evidence="2">
        <location>
            <begin position="34"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="domain" description="LysM" evidence="3">
        <location>
            <begin position="138"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010830"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PJN05767.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="196" mass="21476" checksum="DE282C0A4E01B683" modified="2018-04-25" version="1">MRPMPVIRKRPARRFLLAALPALFTALLTPAAAASPALDPGPGHLNLDVSECVKDQWPWGCLAECESTGRWHINSGNGYYGGLQFWQSTWEEYGGLMYAPRADLATRAEQIAVAEKVLGTQGWRAWPVCSKVLKLDGRVHVVEQGETLSSIAARYEVKGGWQALYEANEQMVGNRPDRLNSGTVLLIPKASAKSLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JGS6</accession>
    <name>A0A2M9JGS6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Aspartate ammonia-lyase</fullName>
            <ecNumber evidence="3">4.3.1.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">aspA</name>
        <name evidence="3" type="ORF">CG723_41595</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.3.1.1" evidence="3"/>
    <dbReference type="EMBL" id="NNBL01000036">
        <property type="protein sequence ID" value="PJN06086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN06086">
        <property type="protein sequence ID" value="PJN06086"/>
        <property type="gene ID" value="CG723_41595"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008797">
        <property type="term" value="F:aspartate ammonia-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.275.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024083">
        <property type="entry name" value="Fumarase/histidase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018951">
        <property type="entry name" value="Fumarase_C_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020557">
        <property type="entry name" value="Fumarate_lyase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000362">
        <property type="entry name" value="Fumarate_lyase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022761">
        <property type="entry name" value="Fumarate_lyase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008948">
        <property type="entry name" value="L-Aspartase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10415">
        <property type="entry name" value="FumaraseC_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00206">
        <property type="entry name" value="Lyase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00149">
        <property type="entry name" value="FUMRATELYASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48557">
        <property type="entry name" value="SSF48557"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00163">
        <property type="entry name" value="FUMARATE_LYASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lyase_1" evidence="1">
        <location>
            <begin position="19"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="domain" description="FumaraseC_C" evidence="2">
        <location>
            <begin position="379"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN06086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="438" mass="46366" checksum="9E33DA11656A6908" modified="2018-04-25" version="1" fragment="single">RTRRQPAHHPRQQPCGSIHLAAVKEAAARANEELGLLAPDKAAAIVEACREIREGKLHDQFVVDVIQGGAGTSTNMNANEVVGNRALELLGHEKGQYEFLHPNEDVNLSQSTNDVYPTAVKIATVFAVRGLLKAMAVLQDAFAGKAVKFRHVLKMGRTQLQDAVPMTLGQEFSAFAVMIDEDRSRLDEAVELIHEINLGATAIGTGLNAPAGYAEAARRHLADITGLPLVTAVNLVEATQDCGAFVQMSGVLKRIAVKLSKSCNDLRLLSSGPRAGLNEINLPPVQAGSSIMPGKVNPVIPEVVNQVAFEVIGNDVTITMAAEAGQLQLNAFEPIILHSLSESITHLRTACLTLAERCVVGITANTEGLRAAVENSIGLVTALNPHIGYTAASDIAKEALATGRGVAELVLEKGLLPAERLAELLRPEVLAGSGSPHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JGZ2</accession>
    <name>A0A2M9JGZ2_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">MDMPI_C domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_40420</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000034">
        <property type="protein sequence ID" value="PJN06150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN06150">
        <property type="protein sequence ID" value="PJN06150"/>
        <property type="gene ID" value="CG723_40420"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010872">
        <property type="entry name" value="MDMPI_C-term_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07398">
        <property type="entry name" value="MDMPI_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MDMPI_C" evidence="1">
        <location>
            <begin position="41"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07398"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN06150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="138" mass="14709" checksum="929E01770B939AC3" modified="2018-04-25" version="1">MTYAQSGVRRHVARHQVQEAAVHAFDAQLATGTPQPVPAVVAVDGIAEFIGISHGTAGPWLHEPARIGLHAAEGESWLVDVTESGSHLIDGPHETDADLHGSASNLLLALHGRLPLDNLRSEGDRATLENLVNWPDLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JH38</accession>
    <name>A0A2M9JH38_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF6286 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CG723_40730</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000034">
        <property type="protein sequence ID" value="PJN06194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN06194">
        <property type="protein sequence ID" value="PJN06194"/>
        <property type="gene ID" value="CG723_40730"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046253">
        <property type="entry name" value="DUF6286"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19803">
        <property type="entry name" value="DUF6286"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="127"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="178"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6286" evidence="3">
        <location>
            <begin position="187"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="289"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="294"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF19803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PJN06194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="334" mass="35251" checksum="02DC9FBF6D214AE9" modified="2018-04-25" version="1">MTGPAQRGTTDIADKAVRRIAERAAEEALPVPASGTGRTSVAVHGRRAAVALRVALPYPAALSDTARRVQRHVAARTGELTGLDIRAARLTVTRLALSSARTPPVAQAEEMPDARRPPRRWWSQRRVPMTVVILPVAAACAAVTADVIRVHATGQGAAAWRMSVVSWLAGHGPGDTSVVVAGAVVALLGVWLIVLALTPGRRQQMPLSVTSREWNAAVDRATVATFVRDAVGDVPGMGAVDVRARRRRVRVRARLAFGDRDQAREQATAIARQALAACGLGRTPRLKLTVTPEPTWQPPASGTPASETPISGTPISETPADLQLTGEVTAGGER</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JH50</accession>
    <name>A0A2M9JH50_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CG723_40760</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000034">
        <property type="protein sequence ID" value="PJN06208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN06208">
        <property type="protein sequence ID" value="PJN06208"/>
        <property type="gene ID" value="CG723_40760"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PJN06208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="97" mass="10658" checksum="250C06162D59D2D0" modified="2018-04-25" version="1">MQVPPPGGLSEPQVRGRACVWCAVALSNSTAIDLGMRETEAHGTAARWFPRGCRPCAIRHAYAAQLDHAQTCEQCTDDPGLCVPGTWLRLVMRQVRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-09-29" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JH74</accession>
    <name>A0A2M9JH74_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_40130</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000033">
        <property type="protein sequence ID" value="PJN06230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN06230">
        <property type="protein sequence ID" value="PJN06230"/>
        <property type="gene ID" value="CG723_40130"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017517">
        <property type="entry name" value="CHP03083_actinobac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034660">
        <property type="entry name" value="DinB/YfiT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010872">
        <property type="entry name" value="MDMPI_C-term_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024344">
        <property type="entry name" value="MDMPI_metal-binding"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07398">
        <property type="entry name" value="MDMPI_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11716">
        <property type="entry name" value="MDMPI_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109854">
        <property type="entry name" value="SSF109854"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03083">
        <property type="entry name" value="TIGR03083"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MDMPI_N" evidence="2">
        <location>
            <begin position="14"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="domain" description="MDMPI_C" evidence="1">
        <location>
            <begin position="143"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07398"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF11716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN06230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="245" mass="26724" checksum="447B4071D13FEB17" modified="2018-04-25" version="1">METAEHIETLNEEGRLLAGAAETAGTDAKVPTCPGWAVRDLLRHVGMVHRWATAFVAEGRTSYHPDNGLPDLDGAELIAWFREGHGRLVGTLAGARPDVECWTFLPAPSPLAFWARRQAHETTVHRVDAESALAGTPGVIPAEFAVDGIEELLLGFHARGRSKVRSDTPRLLRVRATDAERAWTVRVSHEPPVTERDGAGEADCELSGPAARLYLSLWNRLPFPSLTGDASLAALWRERSGITWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JHF6</accession>
    <name>A0A2M9JHF6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ketosynthase chain-length factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CG723_39925</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CB01635</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000032">
        <property type="protein sequence ID" value="PJN06314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN06314">
        <property type="protein sequence ID" value="PJN06314"/>
        <property type="gene ID" value="CG723_39925"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000794">
        <property type="entry name" value="Beta-ketoacyl_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11712">
        <property type="entry name" value="PTHR11712"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02801">
        <property type="entry name" value="Ketoacyl-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Ketoacyl_synth_N" evidence="3">
        <location>
            <begin position="22"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="domain" description="Ketoacyl-synt_C" evidence="4">
        <location>
            <begin position="268"/>
            <end position="372"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PJN06314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="417" mass="42470" checksum="AEAE76E454221B87" modified="2018-04-25" version="1">MSTATMEAPAAPALAPSTTGTVVTGIGVAAPNGLGAEAWWAAVLRGESGIRRLTRFDASGYPVRIAGEVNGFLDEEHLPSRLLRQTDRVTRLSLVAAKEALDDSGTDPADLPAYSAGVVTASSAGGFEFGQRELQELWSKGGQYVSAYQSFAWFYAVNTGQISIRHGLRGSSGVVVSEQAGGLDAVAHARRQIRKGARVMITGGVDSGLCPWGWAAHLAGGGLSTVEDPAAAYLPFAAEATGHVVGEGGALFVLEDAAAAHARGAAAYGTIAGYAATFDGPGTPRLVDAARIALADAGVRPDEIDVVFADAAGERDADRAEAAALTEVFGACGVPVTAPKSMTGRLLAGGASLDLAAALFAVRDQVIPPTTGTARPADDCPVDLVTVTRTGIRLRHALVLARGRGGFNSAAVVSAPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-09-29" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JHM1</accession>
    <name>A0A2M9JHM1_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Alpha-galactosidase</fullName>
            <ecNumber evidence="5">3.2.1.22</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Melibiase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CG723_39650</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CB01635</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>Hydrolysis of terminal, non-reducing alpha-D-galactose residues in alpha-D-galactosides, including galactose oligosaccharides, galactomannans and galactolipids.</text>
            <dbReference type="EC" id="3.2.1.22"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the glycosyl hydrolase 27 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.22" evidence="5"/>
    <dbReference type="EMBL" id="NNBL01000031">
        <property type="protein sequence ID" value="PJN06375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN06375">
        <property type="protein sequence ID" value="PJN06375"/>
        <property type="gene ID" value="CG723_39650"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052692">
        <property type="term" value="F:raffinose alpha-galactosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14792">
        <property type="entry name" value="GH27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.1060">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018905">
        <property type="entry name" value="A-galactase_NEW3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013222">
        <property type="entry name" value="Glyco_hyd_98_carb-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002241">
        <property type="entry name" value="Glyco_hydro_27"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000111">
        <property type="entry name" value="Glyco_hydro_27/36_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041233">
        <property type="entry name" value="Melibiase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038637">
        <property type="entry name" value="NPCBM_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11452">
        <property type="entry name" value="PTHR11452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16499">
        <property type="entry name" value="Melibiase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17801">
        <property type="entry name" value="Melibiase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08305">
        <property type="entry name" value="NPCBM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10633">
        <property type="entry name" value="NPCBM_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00740">
        <property type="entry name" value="GLHYDRLASE27"/>
    </dbReference>
    <dbReference type="SMART" id="SM00776">
        <property type="entry name" value="NPCBM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="SSF49785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00512">
        <property type="entry name" value="ALPHA_GALACTOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4 5" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014961454" description="Alpha-galactosidase" evidence="6">
        <location>
            <begin position="29"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="domain" description="NPCBM" evidence="7">
        <location>
            <begin position="520"/>
            <end position="669"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU361168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PJN06375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="670" mass="71773" checksum="53F7D1D4D240B240" modified="2018-04-25" version="1">MKRILTAVFAAALLAPWLIAAPAGAQNAAEPAAVPLAQTPPMGWNSWNAVGCGVNEKLITDTADRFDALGLKDLGYEYVNIDDCWDLKQRDADGRLVADPAKFPRGLKWLSDYVHERGLKLGIYGDAGTATCAGYPGGLGHEKNDAQQYADWGIDYIKYDNCNNQGLPAQDRYRAMGDAIAATGRNMLFNLCEWGANKPWEWATSVGGHSWRTTGDITDDWDSVKSIVRANLALADYAGPGHWNDPDMLQVGNGGMSDFEYRTHFGMWAMMASPLLLGTDLSTASDATLNLIRNRELTAIDQDPLGRQARVVTETGGRYVLAKPLADGSVAVGLYNENDYTATITTTAAATGVRTAGSYALRDVFTADALRSRGPIEASVPARGLVIYKVRPARAGDTSTPARTFGVDAPLLYDGAPASLVTPGESAAVRTRLADQGSRPLREASVRLDAPEGWRVEPAGRTSAARVTGSRPLATDWRLTPPKDLKPGTYELDATTRYRLDGRTVSDTSTTHVTVADVVPAGDSYLSDTTWVKSTNGWGPMERDMTNGDQAQGDGTPLTIGGTVYPKGLGTHAWSEAVYYTAGHCSTLKAEVGVDDSQDNVGAQRGTVTFEVWKDRTKAVDTGKLSWQGKAVPLDVDVSGSQFVRLVATTADDGNGNDHADWGGLKVTCP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JHW1</accession>
    <name>A0A2M9JHW1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">RimJ/RimL family protein N-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_38665</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000029">
        <property type="protein sequence ID" value="PJN06471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN06471">
        <property type="protein sequence ID" value="PJN06471"/>
        <property type="gene ID" value="CG723_38665"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13302">
        <property type="entry name" value="Acetyltransf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="11"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN06471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="182" mass="20056" checksum="07D8155172D767BC" modified="2018-04-25" version="1">MYTISLGDDGAELRPLETWHAEQFLAHLERGREFIGQHIGFGSNVKDVDSARDLLKSYADKRAADSGSLHGLWLDGTLVGGLLFRIFDAEGGNCEIGCWLEPAAAGRGLVTRGARVLIDWAVLERGIHRVEWVASSANEPSLNVARRLGMRRDGVLREAGSHKGVKQDLEVWSALAPEWRAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JI64</accession>
    <name>A0A2M9JI64_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_38300</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000028">
        <property type="protein sequence ID" value="PJN06558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN06558">
        <property type="protein sequence ID" value="PJN06558"/>
        <property type="gene ID" value="CG723_38300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014715270" evidence="1">
        <location>
            <begin position="44"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN06558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="287" mass="29938" checksum="4C54B665C79B8B02" modified="2018-04-25" version="1">MGGLTIEWTKSAMRGVRVSLTAGIGLLALSACAGPMAPQQRQAESMPTPGKVPKGPRFATAGDLVAAMEKAGLDCETVRSRDYDGSSTTDCVATVDGVKVENEISVFDPDVVSKTEIGTSIESRRTGAYAQTLVAAGNWYIRVMDPPSAPAVAKALHAVVLDAKGKGAETPKYPLPRIPSTPTYKKVDTLADDVAASVGCFQRETTSTGSIKCETGKPGSGSTDCAVLTLHPTHARRDAALREAIKYRGVPAELVTAGNWTVNLCDTTLGGKVARDLGGVVVAYDGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JIC8</accession>
    <name>A0A2M9JIC8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cellulose biosynthesis protein CelD</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_37820</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000027">
        <property type="protein sequence ID" value="PJN06646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN06646">
        <property type="protein sequence ID" value="PJN06646"/>
        <property type="gene ID" value="CG723_37820"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038740">
        <property type="entry name" value="BioF2-like_GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13480">
        <property type="entry name" value="Acetyltransf_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acetyltransf_6" evidence="1">
        <location>
            <begin position="160"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN06646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="364" mass="40656" checksum="4D397FAE79FB7BB2" modified="2018-04-25" version="1">MDITLHRPGELTAADRAAWTAMQSKAHLHGSPELANPFLSPEFTLAMGRCRRGVRIAVVREDGEPAAFFPFQRSVTGVGRAVGLGVSDSQGLVHRPGFEWDARDLLRACGLSVWEFDHLAGGQEPFEAEASGSFPSPVMDVDQGYETYLRVLRERSPKFTRTTLAKDRKLGRDAGEVRYVHDERDPEALATLMEWKSAQYRRTGRSDRFAHPWINRLAQQLFHTSSEPFAGILSVLYAGGKPVAAHFGLRSERVLACWFPAYDPAFAKFSPGLILHLRMAEAASADGIAYLDLGRGQKEYKDSLKTRELTVHEGWVTRRHPVALGHRARRAPVRALRNTVLSRPEFFEPADKLLKRMGKIRSGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JJ53</accession>
    <name>A0A2M9JJ53_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">L-lactate permease</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CG723_37135</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CB01635</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Transports L-lactate across the membrane. Can also transport D-lactate and glycolate.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the lactate permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000025">
        <property type="protein sequence ID" value="PJN06904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN06904">
        <property type="protein sequence ID" value="PJN06904"/>
        <property type="gene ID" value="CG723_37135"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015129">
        <property type="term" value="F:lactate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003804">
        <property type="entry name" value="Lactate_perm"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30003">
        <property type="entry name" value="PTHR30003"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02652">
        <property type="entry name" value="Lactate_perm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00795">
        <property type="entry name" value="lctP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="40"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="71"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="115"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="194"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="222"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="301"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="361"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="393"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="417"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="516"/>
            <end position="537"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU365092"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PJN06904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="538" mass="55319" checksum="BF042B5D92176EC3" modified="2018-04-25" version="1">MFVQQLEPVAGSLGLSALVATLPLVTVLVLLGAVRMKAHLAGLIGLAVAALVACLAYGMPVGQTVSSAAQGALFGLFPIMWIVVNALWVYRMTVGTRHFDILRRSFGRLSDDPRIQALVIAFCFGALLEALAGFGAPVAICSVMLVALGFDPVKAAVVALVANTAPVAFGAMGTPVVTLAQVTGLPLDSVASVVGRQTPLLALVVPLVLVWLVDGRRGLRETWIPALACGVAFAAAQFAASNYVSAQLADIGAALVGAGALVAVPHARRPAAEPVRAAVLTGVRSEELDQDDPRPEILRAYAPYALIVVIFSIAQIPAVKDWIAKATRVFDWPFLNVANPEGKPVGGNLFTLPLVSTGGTLVLLAGAITAAVIGVHARVAVREWLATVYELRFAILTVTSVLALAYVMNLSGQAATIGHFVAVAGAGLAFLSPVLGWFGVAVSGSDTSANALFGALQVTAAQQSGLSPELLAAANSSGGVLGKMISPQNLTIACAAVGLAGKEGDLLRKVLPWSAGLLLVMCLIVMAQSSAVLGWMLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-06-02" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JJ56</accession>
    <name>A0A2M9JJ56_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_37120</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000025">
        <property type="protein sequence ID" value="PJN06901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN06901">
        <property type="protein sequence ID" value="PJN06901"/>
        <property type="gene ID" value="CG723_37120"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043777">
        <property type="entry name" value="DUF5719"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18986">
        <property type="entry name" value="DUF5719"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014974285" evidence="2">
        <location>
            <begin position="24"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="48"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="49"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN06901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="501" mass="50226" checksum="751327D5885DB756" modified="2018-04-25" version="1">MNRTTLSLIAAAGALAAVTGFAAATAPGSGDGDSAKAAARLPVERSSLLCPAPSSSDLAETAYTSYTPASKESGSSGKAALSPATRELTDSTGSGKDKGKADKPVLSPQKPGKPVAGESSGAESPALVGSADGNLAPGWTVQQTTEVAAGTGRGLLGVNCSAPDTDFWFPGASTAKERSDYIHLTNPDDSAAVVDVQLYGANGAIKSDVGEGIQVQPHSSVPVLLSTLTDKPQTNVTLHVTARSGRVAATVLAADDKLGGDWLPASADPADTVVLPGIPKDATSVRLVAFAPGDNDADLKVQLASPTGRISPAGHESLHVKSGMTAAVDLGDVTRGEAGSLILTPTGDSAPVVAALRVVRGKGEDQESAFIPATRPVGARATVADNRAKGSTLSLTAPGAAGTVKVTASAGTEGGTPVSKTYTVKGGTTTSVQPPVPAGLKGSYALTVEQVSGGEVYGSRMLDVPDRDVPGVPMFTVQTLPDDRGMVSVPHADQDLSVLQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JJ72</accession>
    <name>A0A2M9JJ72_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Histidine kinase</fullName>
            <ecNumber evidence="3">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CG723_36080</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CB01635</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="3"/>
    <dbReference type="EMBL" id="NNBL01000024">
        <property type="protein sequence ID" value="PJN06925.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN06925">
        <property type="protein sequence ID" value="PJN06925"/>
        <property type="gene ID" value="CG723_36080"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00672">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00304">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="HAMP" evidence="9">
        <location>
            <begin position="187"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="8">
        <location>
            <begin position="262"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="55"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="59"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PJN06925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="474" mass="50742" checksum="6BBAB36BD5A26DBA" modified="2018-04-25" version="1">MRRLPPRTLRGQLTAGLVALLALACLAVGITTALALRGFLMGRLDEQLVTSGGRFPASLEHEAEPDSDNRPDTRGQADDTFGARLLAGTVTQAAVVDDATDRPIDLTSEDRRTLAAVPTDGRGHSIRLSTLRSYRVMAFQGDDQDTLITGLSLRPVEETVHRLEAVETVLFGAALVITGIAGAVWVRISLRPLQRVTARSAEVAGLPLASGEIAMPGPLPDTDPRTEVGQVGSALNHMLGHIENALTSRQASEERLRHFAADASHELRTPVANIRGHAELALRHSGPVPQEVRHSLERIGSESQRMTRLVDDLLLLARLDAGRPLEHEPVDLTLLILNATDDARAAGPDHRWLLDLPEEPVTVTGDAHRLQQAIGNVLANARTHTPPSTEVSITLTKGPADVCLSVSDNGPGIPEELQPEVFGRFVRADHARSRSTGSTGLGLAIVQAVITAHGGTTVLRSRPGRTTIRVTLPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JJI0</accession>
    <name>A0A2M9JJI0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_35390</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000023">
        <property type="protein sequence ID" value="PJN07024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN07024">
        <property type="protein sequence ID" value="PJN07024"/>
        <property type="gene ID" value="CG723_35390"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012495">
        <property type="entry name" value="TadE"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07811">
        <property type="entry name" value="TadE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="26"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN07024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="149" mass="15075" checksum="928160C3ED35672A" modified="2018-04-25" version="1">MGRAGRRRPRAGERQAGTRRAGDQGFVTAEAAVVLPVLVTFTLALVWALMAASAQIQCVDAARAGARAIARQDPQGAAVESAKRVAPRGAKVAVSREGDLVRVAVEAAAPGPGVLNVRLRADAVALAEETVGTAEPADVAGTAEAVGDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JK85</accession>
    <name>A0A2M9JK85_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Urease accessory protein UreD</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">ureD</name>
        <name evidence="4" type="ORF">CG723_34755</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CB01635</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Required for maturation of urease via the functional incorporation of the urease nickel metallocenter.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">UreD, UreF and UreG form a complex that acts as a GTP-hydrolysis-dependent molecular chaperone, activating the urease apoprotein by helping to assemble the nickel containing metallocenter of UreC. The UreE protein probably delivers the nickel.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the UreD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000022">
        <property type="protein sequence ID" value="PJN07273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN07273">
        <property type="protein sequence ID" value="PJN07273"/>
        <property type="gene ID" value="CG723_34755"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016151">
        <property type="term" value="F:nickel cation binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006807">
        <property type="term" value="P:nitrogen compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01384">
        <property type="entry name" value="UreD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002669">
        <property type="entry name" value="UreD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01774">
        <property type="entry name" value="UreD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0143">Chaperone</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0996">Nickel insertion</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PJN07273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="251" mass="26078" checksum="B3B3DB664C541B6E" modified="2018-04-25" version="1">MTAGVRSTARITASDDGRGGTCLPVLDAEGSLALRRIRSTGPDARVMLVGAMSGPLGGDHMSVEAHVTAGARLRIGSVAATIALPGQAKGEARYDVRLTVDDGAELHWLPEQLISACESDLRVATRAELAPGARLVLREEQVLGRTGEEPGRLASRLTVHRAGRPLLDQELACGPGAPGGWDGPAVLAGHRALGQLVVVRPEFEKDRPSPALLGENAALTPLAGPAVLVTALASDALRLRGTLDDALRRLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JKI0</accession>
    <name>A0A2M9JKI0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Betaine-aldehyde dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CG723_34565</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CB01635</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000021">
        <property type="protein sequence ID" value="PJN07376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN07376">
        <property type="protein sequence ID" value="PJN07376"/>
        <property type="gene ID" value="CG723_34565"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016620">
        <property type="term" value="F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016160">
        <property type="entry name" value="Ald_DH_CS_CYS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="SSF53720"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00070">
        <property type="entry name" value="ALDEHYDE_DEHYDR_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00687">
        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldedh" evidence="5">
        <location>
            <begin position="10"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="248"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PJN07376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="500" mass="53233" checksum="2736F46F2ABED895" modified="2018-04-25" version="1">MPDLFIGGGWTTARDERTREIRCPADGSLVAVVDEAGGKDTADAIAAARHAFDEGPWPRMSAAEHGDLLLRVADLLVRDKDALARAESLDTGKRLVESAYDIDDIANCFRYFGRLAAADTGRVVETGTEGAESRVLYEPVGVCALITPWNYPLLQTAWKVAPALAAGNTFVLKPSELTPHTAIHLMRLLDEAGLPAGVANLVLGAGPEAGAPLGDHPDVDLVSFTGGLQTGRLLMAAAAGSVKKVALELGGKNPNIVFADADFDAAVDMALTAVFLHSGQVCSAGARLLVEDSLHDRFVDEVVRRAELIRLGGPFDEDAQTGPLISAAHRAKVEAYVARGIEEGAVLRCGGERPKPAAYEQGFYYLPTVLDECTSGMSVVQDESFGPVLTVERFTDEAEAVRLANDSIYGLAGAVWTSDEAKAARVAGALRLGTVWINDYHPYVPQAEWGGYKQSGSGRELGPSGLAEYRETKHIWRNTQPVAQGWFGAPPECPEDGDPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JKT3</accession>
    <name>A0A2M9JKT3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">TetR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CG723_33895</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000020">
        <property type="protein sequence ID" value="PJN07485.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN07485">
        <property type="protein sequence ID" value="PJN07485"/>
        <property type="gene ID" value="CG723_33895"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023772">
        <property type="entry name" value="DNA-bd_HTH_TetR-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041347">
        <property type="entry name" value="MftR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17754">
        <property type="entry name" value="TetR_C_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01081">
        <property type="entry name" value="HTH_TETR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="3">
        <location>
            <begin position="21"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="44"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PJN07485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="210" mass="22752" checksum="0454FCF3DE45EF69" modified="2018-04-25" version="1">MPSPARTSSAAGEGLRARRRRETEHAIHAAAVRLVEGHGLAGVTVDMISAAAGISQRTFFNYFPSKESALTISPPPLPDALHLRLTHGDPAPRATLTELLDVLSAHITDDVVPDRELVQATFRIADRHPELRAALHARFDAFEEQVREAVAERMAAPPADPRPRLLTGIALAVTRTALEQWSLGAAGDHASPEPDLRQCVDLLHTLMPKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-05-25" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JKU1</accession>
    <name>A0A2M9JKU1_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Biotin carboxylase</fullName>
            <ecNumber evidence="2">6.3.4.14</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CG723_33885</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">CB01635</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>biotin</name>
            <dbReference type="ChEBI" id="CHEBI:57586"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.14" evidence="2"/>
    <dbReference type="EMBL" id="NNBL01000020">
        <property type="protein sequence ID" value="PJN07483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN07483">
        <property type="protein sequence ID" value="PJN07483"/>
        <property type="gene ID" value="CG723_33885"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004075">
        <property type="term" value="F:biotin carboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034733">
        <property type="entry name" value="AcCoA_carboxyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005481">
        <property type="entry name" value="BC-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011764">
        <property type="entry name" value="Biotin_carboxylation_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005482">
        <property type="entry name" value="Biotin_COase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000089">
        <property type="entry name" value="Biotin_lipoyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005479">
        <property type="entry name" value="CbamoylP_synth_lsu-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011763">
        <property type="entry name" value="COA_CT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011054">
        <property type="entry name" value="Rudment_hybrid_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011053">
        <property type="entry name" value="Single_hybrid_motif"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02785">
        <property type="entry name" value="Biotin_carb_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00289">
        <property type="entry name" value="Biotin_carb_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00364">
        <property type="entry name" value="Biotin_lipoyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01039">
        <property type="entry name" value="Carboxyl_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02786">
        <property type="entry name" value="CPSase_L_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00878">
        <property type="entry name" value="Biotin_carb_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51230">
        <property type="entry name" value="SSF51230"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51246">
        <property type="entry name" value="SSF51246"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="SSF52440"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50979">
        <property type="entry name" value="BC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50968">
        <property type="entry name" value="BIOTINYL_LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50989">
        <property type="entry name" value="COA_CT_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0092">Biotin</keyword>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Biotin carboxylation" evidence="11">
        <location>
            <begin position="1"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-grasp" evidence="10">
        <location>
            <begin position="118"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="domain" description="Lipoyl-binding" evidence="9">
        <location>
            <begin position="460"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="domain" description="CoA carboxyltransferase C-terminal" evidence="12">
        <location>
            <begin position="816"/>
            <end position="1059"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1056"/>
            <end position="1081"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1063"/>
            <end position="1081"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PJN07483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="1081" mass="114659" checksum="2686BA64E806DAD7" modified="2018-04-25" version="1">MTRVLIANRGEIAVRIHRAASALGLRTVAVHSADDRSAAHVRLADEAHLLKGEGVAAYLDARQIVEIAGRAGCDLVHPGYGFLSENADFATACAEAGLTFVGPTPELLALFGDKASSRALAVRHGVPVLAATGASTSLAQATEFLAGVRDGVMVKAVAGGGGRGMRAVHDASDLAWAYERCRSEAERAFGNGDVYVEQLLPRAKHIEIQVVGDGTGQVTHLWDRECSVQRRNQKLIEVAPSPWLPARTRDLLIEAAVTMASATRYLGLGTFEFLVDADDPDAYYFIETNPRLQVEHTITEELAGVDLVATQLRLAQGRSLAELGLLQEEIPQPRGFAIQTRVNLEELSADGTARASQGTLTAFEAPGGPGVRVDTHGRAGLEIKGSYDSLVAKVITRTVRGDFADAAGRAAGALAEFTLSGVPSNIPLLRAVLRHEAFRDGTVTTAFVNEHLDKLVPGATASQESHGSVLTALSAGSVVDVCVEPGAEVAAGAPLVVLEAMKMEHVLTAPRGGIVREVRASVGDVVPAGAELVVFAPSQGEDGVDEAAADVDLDVIRPDLAEVVERHRIGLDEARPQAVERRRRTGHRTARENLADLCDPGSFTEYGALAIAAQRRRRTLEDLIANTPADGIVTGVAQVNGAQFGDRRSQCAVLAYDYTVLAGTQGMLNHKKTDRMLELAERQQIPVVLFAEGGGGRPGDTDMMAVAGLDVPTFATLARLSGQVPTVGIVAGRCFAGNAALLGCCDVVIATPDATVGMSGPAMIEAGGLGQFLPEEVGPMPVQVPNGVVDILVDDEAGAVAVAKQYLSYFQGDLSDWGCADQRLLRHVVPENRLRAYDVREAVTLLADTGSVLELRREFGVGVITALVRVEGRPMGLVANNPQHLGGAIDSDAADKMARFLQLCDAHGLPVVTLCDTPGFMVGPDAEKTATVRHFSRLFVAGAHLGVPVFSAVLRKGYGLGAMAMTGGGFRAPTAMVSWPTGEIGPMGLEGAVRLGYRRELEAIADPQERQATYEALLAEQYEQGKALNAGTTFEVDDVIDPADTRRWITTTFAQHPTHPDSYPHPRTPEGRTRGRFIDTW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JKU7</accession>
    <name>A0A2M9JKU7_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HTH tetR-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_33880</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000020">
        <property type="protein sequence ID" value="PJN07482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN07482">
        <property type="protein sequence ID" value="PJN07482"/>
        <property type="gene ID" value="CG723_33880"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023772">
        <property type="entry name" value="DNA-bd_HTH_TetR-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01081">
        <property type="entry name" value="HTH_TETR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="19"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="42"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN07482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="212" mass="23080" checksum="C9351F0ADEE6C551" modified="2018-04-25" version="1">MPIARKSWTVRDKLDRQDSATRARLLTAARTVFEQRGYARTTIADITAESDVGRATFYVYFASKQDVFAVLAADLRDRFLAAQEAAAPEAEDPYLLAERTNAAFLDAYVDNLAFLTVLEHQSLTDPAMRVLRDEINDRPRGRTARYIAGLVRQGLAEPAGSPESVATAAAGMVAGFARAVAADPGYRDRAVADLTAMYLRLLGLTPRAGAKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-05-25" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JKZ0</accession>
    <name>A0A2M9JKZ0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alcohol dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_33775</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000020">
        <property type="protein sequence ID" value="PJN07522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN07522">
        <property type="protein sequence ID" value="PJN07522"/>
        <property type="gene ID" value="CG723_33775"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="PKS_ER"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PKS_ER" evidence="1">
        <location>
            <begin position="22"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN07522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="324" mass="33487" checksum="45558C83336B1B22" modified="2018-04-25" version="1">MDSASQALVPEESRALVLEEFGTLPRLVERPVPAPRPSHTLVRTRAATVAHLDLNILDGQFGILPELPFVPGTQGSGTVLASAVYPEGALVRVRGEGIGLSRDGAWAEHLLVPDTAVEVMPEGTDPVLAAIYFSPVGTAFAAVHPIAQVQSGERVLVTGASGAVGALVVQLAARAGAEVIGVVGRPAKLGQVPASAKPVLAADLCAEVIGGPVDVLIDTVGGAVLRDALTLVRPRGRAALLGYTAGRELSLDLADFFLADVTLLPVNMISRGKEVAPDVVRLLPDLASGELSLPHERYGIEELPEAVARLRTGAAVGRVVLDLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JL10</accession>
    <name>A0A2M9JL10_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Protease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CG723_32755</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000019">
        <property type="protein sequence ID" value="PJN07542.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN07542">
        <property type="protein sequence ID" value="PJN07542"/>
        <property type="gene ID" value="CG723_32755"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001940">
        <property type="entry name" value="Peptidase_S1C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13180">
        <property type="entry name" value="PDZ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00834">
        <property type="entry name" value="PROTEASES2C"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="SSF50156"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="SSF50494"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="133"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="3">
        <location>
            <begin position="405"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PJN07542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="501" mass="48505" checksum="38D587E92F2657AA" modified="2018-04-25" version="1">MSTENEGTSVPPAPSAPPVPVESPATPAPAGSAPPPEPADAPTAVIPPVEGAAPGAHEGPGAASGAAPGLGAASGAAPGPGGQDEAAHAASGGWPPPPPAVPPYGDGGGGGHHPWGASYQAPEPTPGRRRGGLLAAVVAAALIAGGVGGGIGYWAAERNDDGGADSTTVSASDNPAGFKRDAASVAGIAANALPSTVTIEAEGSDGEGGTGSGFVYDTQGHILTNNHVVASAADGGKLSATFSNGKKYDAEVIGRAQGYDVAVIKLKNAPSNLKPLQLANSDKVAVGDATIAIGAPFGLSNTVTTGIVSAKNRPVASSDSSGSSKASYMNALQTDASINPGNSGGPLLDARGAVIGINSAIQPASSGGIGGSGQSGSVGLGFAIPINQARNVAKQLIKTGEPVYPVIGASVALDEQGDGAKITEQGAGGSSAVTANGPADKAGLKPGDVITKLDDSVIDSGPTLIGQIWTHKPGDTVKITYKRGGAEHTVDVVLGERKGDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JL71</accession>
    <name>A0A2M9JL71_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Membrane protein insertase YidC</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Foldase YidC</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Membrane integrase YidC</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Membrane protein YidC</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">CG723_33185</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">CB01635</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Required for the insertion and/or proper folding and/or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins. Aids folding of multispanning membrane proteins.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Interacts with the Sec translocase complex via SecD. Specifically interacts with transmembrane segments of nascent integral membrane proteins during membrane integration.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13">Membrane</location>
            <topology evidence="1 13">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the OXA1/ALB3/YidC family. Type 1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000019">
        <property type="protein sequence ID" value="PJN07621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN07621">
        <property type="protein sequence ID" value="PJN07621"/>
        <property type="gene ID" value="CG723_33185"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032977">
        <property type="term" value="F:membrane insertase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028055">
        <property type="entry name" value="Membr_insert_YidC/Oxa1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001708">
        <property type="entry name" value="YidC/ALB3/OXA1/COX18"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12428">
        <property type="entry name" value="PTHR12428"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02096">
        <property type="entry name" value="60KD_IMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03592">
        <property type="entry name" value="yidC_oxa1_cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 13 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 15" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="7"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="35"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="217"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="330"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="330"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="376"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="14">
        <location>
            <begin position="415"/>
            <end position="429"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00025034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00026028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00031538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00033245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00033342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU003945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="PJN07621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="429" mass="47467" checksum="31F2D50937FDB5A0" modified="2018-04-25" version="1">MDTIAGFFSFITTPVSWVIVQFHSLYGAIFGPDTGWAWGLSIVSLVILIRICLIPLFVKQIKATRAMQTLQPEMKKIQERYKNDKQRQSEEMMKLYKETGTNPLSSCLPILAQSPFFFALYHVLNGIATGTTIGVIDDNLLASARKAHIFGAPLAAKFTDSADKVASLGATLTDVRVVTAIMIVLMSASQFYTQRQLMTKNVDMTVKTPFMQQQKMLMYVFPVMFAVFGINFPVGVLVYWLTTNVWTMGQQMYVIRQNPTPGSKAQAAHLERLLKHVTHAEKTRNRRERGIVKAIVAKGRDRNEFERKFINGLTKVNLAAQADGTLVKSTAGTLTEDEDGTQTTGGTPKRQQPKRQSKSQRQHGTAQGAAKDESEAPEPMSLEKKDEAEDAKPEAKQTGGKPASGTPARSKAKSGQRKGPQRPKSPSKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JL90</accession>
    <name>A0A2M9JL90_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_33310</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0749 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000019">
        <property type="protein sequence ID" value="PJN07641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN07641">
        <property type="protein sequence ID" value="PJN07641"/>
        <property type="gene ID" value="CG723_33310"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010273">
        <property type="entry name" value="DUF881"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37313">
        <property type="entry name" value="PTHR37313"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05949">
        <property type="entry name" value="DUF881"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="24"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN07641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="260" mass="27890" checksum="A1916EFF2B89E9C6" modified="2018-04-25" version="1">MSNSADSWEEPPGGGRPRVRLRPVRLLTVAVFALAGLIFFTSFNTAKGTNIRTDASLLKLSDLIQERSHKNGQLEESNSAIRDDVDALTERGGAGTKAEDAKLSALEKASGTKKLRGQAVSVTLADAPPNATAKLPGYPEPQPNDLVIHQQDLQAVVNALWNGGAQGIKVMDQRLIATSAVRCVGNTLILQGRVYSPPYKITAVGDPERLKQALAVSPQIQNYMLYVNAYGLGWKVEDDGAVTLPGYSGTVDLHYAKPVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JLC8</accession>
    <name>A0A2M9JLC8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Peptidylprolyl isomerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_31860</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000018">
        <property type="protein sequence ID" value="PJN07675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN07675">
        <property type="protein sequence ID" value="PJN07675"/>
        <property type="gene ID" value="CG723_31860"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000413">
        <property type="term" value="P:protein peptidyl-prolyl isomerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002130">
        <property type="entry name" value="Cyclophilin-type_PPIase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044666">
        <property type="entry name" value="Cyclophilin_A-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45625">
        <property type="entry name" value="PTHR45625"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00160">
        <property type="entry name" value="Pro_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="SSF50891"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50072">
        <property type="entry name" value="CSA_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPIase cyclophilin-type" evidence="2">
        <location>
            <begin position="117"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="58"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN07675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="270" mass="28405" checksum="EBEE933143C73892" modified="2018-04-25" version="1">MVSNDQRRRQLAREKFLRQQQRRESARRRARTRNTVIASALAVVVVAGAGAFAAGAFDGKDKKDSAASKPSASPSKAADPCEKPAAGKVKPLSWKKEPALTIDKSAGYTMNLATTCGDIGIGLKAKEAPHTVNSFDFLAGKGFFDHTKCHRLTTNGIYVLQCGDPKGTGAGGPGYTIPDENLKDKSLKGNVYPAGTIAMANTGQKHTGGSQFFLVYQDSQLPPSYTPFGTISDSGMKVLKKIAAAGESTGQGDGAPNATVVIDKATVKKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JLS3</accession>
    <name>A0A2M9JLS3_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">tRNA (adenine(58)-N(1))-methyltransferase TrmI</fullName>
            <ecNumber evidence="4">2.1.1.220</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CG723_32630</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CB01635</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>adenosine(58) in tRNA + S-adenosyl-L-methionine = H(+) + N(1)-methyladenosine(58) in tRNA + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:43152"/>
            <dbReference type="Rhea" id="RHEA-COMP:10365"/>
            <dbReference type="Rhea" id="RHEA-COMP:10366"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74411"/>
            <dbReference type="ChEBI" id="CHEBI:74491"/>
            <dbReference type="EC" id="2.1.1.220"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homotetramer composed of a dimer of dimers.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the class I-like SAM-binding methyltransferase superfamily. TRM61 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.220" evidence="4"/>
    <dbReference type="EMBL" id="NNBL01000018">
        <property type="protein sequence ID" value="PJN07812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN07812">
        <property type="protein sequence ID" value="PJN07812"/>
        <property type="gene ID" value="CG723_32630"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031515">
        <property type="term" value="C:tRNA (m1A) methyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016429">
        <property type="term" value="F:tRNA (adenine-N1-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014816">
        <property type="entry name" value="tRNA_MeTrfase_Gcd14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12133">
        <property type="entry name" value="PTHR12133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08704">
        <property type="entry name" value="GCD14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017269">
        <property type="entry name" value="GCD14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51620">
        <property type="entry name" value="SAM_TRM61"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4 5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0819">tRNA processing</keyword>
    <feature type="region of interest" description="S-adenosyl-L-methionine binding" evidence="5">
        <location>
            <begin position="117"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="272"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="138"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="168"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="184"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR017269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR017269-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PJN07812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="301" mass="32819" checksum="30A80845E6ECB4F0" modified="2018-04-25" version="1">MSEPTGAARRRGPFKVGDQVQLTDPKGRHYTFTLEAGKNFHTHKGSFPHDELIGAPEGSVVRTTGNVAYLALRPLLPDYVLSMPRGAAVVYPKDAGQILAFADIFPGARVVEAGVGSGSLSSFLLRAIGDEGMLHSYERREDFAEIATQNVERYFGGSHPAWQLTVGDLQDNLSDADVDRVILDMLAPWECLEVVSKALVPGGILCCYVATTTQLARTVESIREIGCFNEPTSWESMIRNWHVEGLAVRPDHRMIGHTGFLLTARRLADGVEPPMRRRRPAKGAYGEDYSGPNADGGNAGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JLX4</accession>
    <name>A0A2M9JLX4_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ADF-H domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CG723_31260</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CB01635</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the actin-binding proteins ADF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000017">
        <property type="protein sequence ID" value="PJN07876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN07876">
        <property type="protein sequence ID" value="PJN07876"/>
        <property type="gene ID" value="CG723_31260"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015629">
        <property type="term" value="C:actin cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030042">
        <property type="term" value="P:actin filament depolymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002108">
        <property type="entry name" value="ADF-H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029006">
        <property type="entry name" value="ADF-H/Gelsolin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017904">
        <property type="entry name" value="ADF/Cofilin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11913">
        <property type="entry name" value="PTHR11913"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00241">
        <property type="entry name" value="Cofilin_ADF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00102">
        <property type="entry name" value="ADF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51263">
        <property type="entry name" value="ADF_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ADF-H" evidence="3">
        <location>
            <begin position="3"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PJN07876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="135" mass="15251" checksum="D446014F1DA0D912" modified="2018-04-25" version="1">MVTSAISVEDRCIDAFNELKTSRHITTVLYRLNDKLDTLILDFEGNLTHDELLKALPSDPRLVAYELCFADRDGRRREAIVLISWSPQSVSPEQGAAHTAVYVALRNQLDGVDLFVEAMSQTDLEYNRLVRAART</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JM05</accession>
    <name>A0A2M9JM05_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">LLM class F420-dependent oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_31500</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000017">
        <property type="protein sequence ID" value="PJN07906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN07906">
        <property type="protein sequence ID" value="PJN07906"/>
        <property type="gene ID" value="CG723_31500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019910">
        <property type="entry name" value="Lucif-like_OxRdtase_MSMEG_4879"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011251">
        <property type="entry name" value="Luciferase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036661">
        <property type="entry name" value="Luciferase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00296">
        <property type="entry name" value="Bac_luciferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51679">
        <property type="entry name" value="SSF51679"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03564">
        <property type="entry name" value="F420_MSMEG_4879"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bac_luciferase" evidence="1">
        <location>
            <begin position="10"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN07906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="305" mass="32117" checksum="A1B4E23DB5E1DF0C" modified="2018-04-25" version="1">MTIGVTLSLQNRVDSAVQLAREAHEAGLRSAWFGQTFAYDSPTLAAIVGREVPGLHVGTAAIPIFGRHPLLVSSQAQTAQAATGGRYHLGLALGTKQLTEAAFGFPYERPIGRLREFLTALRQLLETGNSDFHGELLNATTPLPAQVPGAEPPVPLLVAAMGPQALRVSGELADGILPLLAGPRALSEHIVPAVTAAAEVAGRPAPRIVAFVPGVVTADAETVRETATGTLSFYEQFPSYQRVIGLSGATRAVDLAVIGDEETVAAEVRRYREAGATEVVFTSTDLGGEADRRRTWKLLGELANA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JM52</accession>
    <name>A0A2M9JM52_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_31115</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000017">
        <property type="protein sequence ID" value="PJN07945.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN07945">
        <property type="protein sequence ID" value="PJN07945"/>
        <property type="gene ID" value="CG723_31115"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014942137" evidence="1">
        <location>
            <begin position="24"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN07945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="112" mass="11609" checksum="25DB0407116FA9FF" modified="2018-04-25" version="1">MRRIVVLWGAAVFCLAAPAQSFADSGTAPKAAYCGTDGATGLAVSAAGNVSCRAALQAAAAYTKAWHSTAAKPVQVRRAGTTWQCQERPGDPNPYQACVDAQDHTRLVTLSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-05-25" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JMK7</accession>
    <name>A0A2M9JMK7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_30595</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000016">
        <property type="protein sequence ID" value="PJN08037.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08037">
        <property type="protein sequence ID" value="PJN08037"/>
        <property type="gene ID" value="CG723_30595"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045981">
        <property type="entry name" value="DUF5937"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001845">
        <property type="entry name" value="HTH_ArsR_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19361">
        <property type="entry name" value="DUF5937"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00778">
        <property type="entry name" value="HTHARSR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00418">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50987">
        <property type="entry name" value="HTH_ARSR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH arsR-type" evidence="1">
        <location>
            <begin position="264"/>
            <end position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN08037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="356" mass="39537" checksum="3058B896679C19D0" modified="2018-04-25" version="1">MPVVIEPGPDPDRAVAPRLSPLAELCACLHALQTPGHHPASRRWVDAVRQDADPALLARAVALSPLWSAFRARYLLPLSAGVERSLEEEIADITTLDLEQFTGMTAQALLGKNSPRPGAPLEEPDRFLSRLRQHAEERFTLGARLLSDPEGLRDTVTGFLTAAGEEWFGAEWERLAGPLRAEVRARFAEHRNDGVAVLASFPSARLLADPPRIEFEKLYQARVPLAGTDCLLTPSLHVNPHLAIKHYPGFPVVVQYPVRGPGSMGPPSLDLVRHRIKALQEPLRIDLCRTLLREAMTTTELAEQYAMTPPQMSRHLRRLREAGMVVTHRRGAQVHYQLDQEAVRTLGHDLLAALHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JMR9</accession>
    <name>A0A2M9JMR9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Succinate dehydrogenase/fumarate reductase iron-sulfur subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CG723_29595</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CB01635</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[3Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:21137"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000015">
        <property type="protein sequence ID" value="PJN08162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08162">
        <property type="protein sequence ID" value="PJN08162"/>
        <property type="gene ID" value="CG723_29595"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00207">
        <property type="entry name" value="fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1060.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036010">
        <property type="entry name" value="2Fe-2S_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001041">
        <property type="entry name" value="2Fe-2S_ferredoxin-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006058">
        <property type="entry name" value="2Fe2S_fd_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009051">
        <property type="entry name" value="Helical_ferredxn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004489">
        <property type="entry name" value="Succ_DH/fum_Rdtase_Fe-S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025192">
        <property type="entry name" value="Succ_DH/fum_Rdtase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13085">
        <property type="entry name" value="Fer2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13183">
        <property type="entry name" value="Fer4_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54292">
        <property type="entry name" value="SSF54292"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00384">
        <property type="entry name" value="dhsB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00197">
        <property type="entry name" value="2FE2S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51085">
        <property type="entry name" value="2FE2S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="2Fe-2S ferredoxin-type" evidence="3">
        <location>
            <begin position="6"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PJN08162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="256" mass="28658" checksum="D3AC1355C328E390" modified="2018-04-25" version="1">MSSYDARFRVWRGDAEGGGLTDFSVEVNDGEVVLDIIHRIQATQASDLAVRWNCKAGKCGSCSAEINGRPRLMCMTRMSVFDREDVITVTPLRAFPVVRDLVTDVGFNYAKAREIPAFVPPAGVGPGEYRMQQADVDRSQEFRKCIECFLCQDTCHAVRDHEENKAAFAGPRFLMRVAELDMHPLDAASDSGLDRKRTAQEDHGLGYCNITKCCTEVCPEGIHITDNALIPLKERAVDRKYDPVVWLGNKIRRRSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JMW8</accession>
    <name>A0A2M9JMW8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CG723_29570</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000015">
        <property type="protein sequence ID" value="PJN08157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08157">
        <property type="protein sequence ID" value="PJN08157"/>
        <property type="gene ID" value="CG723_29570"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PJN08157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="155" mass="16667" checksum="B9868D1F7B0643F7" modified="2018-04-25" version="1">MKSDVIRRGGRGSTAAWEVIGVIDTDGECAEWVFPEEPGAVRSARAAVRGQLGVWDLDSLGDVTELLVSELVTNALRHASGPIGVRLLRSAEPAHTLRVEVSDRLPDPPLERVAGPDEESGRGLQLVAGSARRWGTRPGDTGKTVWFELSLPGRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JN17</accession>
    <name>A0A2M9JN17_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">4-hydroxy-3-methylbut-2-enyl diphosphate reductase</fullName>
            <shortName evidence="5">HMBPP reductase</shortName>
            <ecNumber evidence="5">1.17.7.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">ispH</name>
        <name evidence="6" type="ORF">CG723_29415</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CB01635</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP/MEP pathway for isoprenoid precursor biosynthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>H2O + isopentenyl diphosphate + 2 oxidized [2Fe-2S]-[ferredoxin] = (2E)-4-hydroxy-3-methylbut-2-enyl diphosphate + 2 H(+) + 2 reduced [2Fe-2S]-[ferredoxin]</text>
            <dbReference type="Rhea" id="RHEA:24488"/>
            <dbReference type="Rhea" id="RHEA-COMP:10000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10001"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33737"/>
            <dbReference type="ChEBI" id="CHEBI:33738"/>
            <dbReference type="ChEBI" id="CHEBI:128753"/>
            <dbReference type="ChEBI" id="CHEBI:128769"/>
            <dbReference type="EC" id="1.17.7.4"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>dimethylallyl diphosphate + H2O + 2 oxidized [2Fe-2S]-[ferredoxin] = (2E)-4-hydroxy-3-methylbut-2-enyl diphosphate + 2 H(+) + 2 reduced [2Fe-2S]-[ferredoxin]</text>
            <dbReference type="Rhea" id="RHEA:24825"/>
            <dbReference type="Rhea" id="RHEA-COMP:10000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10001"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33737"/>
            <dbReference type="ChEBI" id="CHEBI:33738"/>
            <dbReference type="ChEBI" id="CHEBI:57623"/>
            <dbReference type="ChEBI" id="CHEBI:128753"/>
            <dbReference type="EC" id="1.17.7.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="5">Binds 1 [4Fe-4S] cluster per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="5">Isoprenoid biosynthesis; dimethylallyl diphosphate biosynthesis; dimethylallyl diphosphate from (2E)-4-hydroxy-3-methylbutenyl diphosphate: step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="5">Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via DXP pathway; isopentenyl diphosphate from 1-deoxy-D-xylulose 5-phosphate: step 6/6.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the IspH family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.17.7.4" evidence="5"/>
    <dbReference type="EMBL" id="NNBL01000015">
        <property type="protein sequence ID" value="PJN08260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08260">
        <property type="protein sequence ID" value="PJN08260"/>
        <property type="gene ID" value="CG723_29415"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00056">
        <property type="reaction ID" value="UER00097"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00059">
        <property type="reaction ID" value="UER00105"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051745">
        <property type="term" value="F:4-hydroxy-3-methylbut-2-en-1-yl diphosphate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050992">
        <property type="term" value="P:dimethylallyl diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019288">
        <property type="term" value="P:isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016114">
        <property type="term" value="P:terpenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd13944">
        <property type="entry name" value="lytB_ispH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00191">
        <property type="entry name" value="IspH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003451">
        <property type="entry name" value="LytB/IspH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30426">
        <property type="entry name" value="PTHR30426"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02401">
        <property type="entry name" value="LYTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00216">
        <property type="entry name" value="ispH_lytB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="3 5" id="KW-0408">Iron</keyword>
    <keyword evidence="4 5" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="5" id="KW-0414">Isoprene biosynthesis</keyword>
    <keyword evidence="2 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="5">
        <location>
            <begin position="229"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="5">
        <location>
            <position position="133"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="19"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="48"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="81"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="103"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="131"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="171"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="201"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="274"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PJN08260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="332" mass="35606" checksum="0AF4D91D2BDB8B14" modified="2018-04-25" version="1">MTATTGPRRVLLAAPRGYCAGVDRAVIAVEKALEQYGAPIYVRHEIVHNKYVVQTLERKGAIFVEQTQEVPEGSIVMFSAHGVAPVVHDEAAAGKLATIDATCPLVTKVHKEAVRFANEDYDILLIGHEGHEEVIGTSGEAPDHITLVDGPEDVANVEVRDESKVVWLSQTTLSVDETMETVDALKAKFPNLLSPPSDDICYATQNRQIAVKKLAEDAELVIVVGSKNSSNSIRMVEVALDAGAPAAHLVDFAAEIDESWLEGVTTVGLTSGASVPDVLVDGVLEWLAERGYADVETVKTAEESITFSLPKELRRDLRAEAAALTGDGSSEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JNP9</accession>
    <name>A0A2M9JNP9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Histidine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_28835</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000014">
        <property type="protein sequence ID" value="PJN08496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08496">
        <property type="protein sequence ID" value="PJN08496"/>
        <property type="gene ID" value="CG723_28835"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.130">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013517">
        <property type="entry name" value="FG-GAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028994">
        <property type="entry name" value="Integrin_alpha_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01839">
        <property type="entry name" value="FG-GAP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69318">
        <property type="entry name" value="SSF69318"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN08496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="408" mass="40717" checksum="A1D9DF210A0F56DC" modified="2018-04-25" version="1">MVAAVTGCGGDDKPAAAKHRPVAMAGKSGAALPVPHGRGSKVPHDFNGDGAPDLVLDDLVHDGLGDDAGIGVVYGKKGHGLVPGARQLLRPAKYAAPTKGETPAAFDSEASCDLDKDGFTDLVVSTDPPFDGQGQPPVPLQILFGGPGGLTHQGVKLVVPAQARFGNDWPDQPVCGDFDGDGSVDLTVHASGGRLSFLRGPFTRKGAPRAAGKPLTAPGNVPVGPAFDVDRDGYDDLLVRRTSRGSSPSRIVLGGPQGPARSGAALPSGLGLAVGRFTKGAGADTALLTASGVTLSQPGAAALKATGTAITAGDFDGDGVAELVVSGGASKAPKVLPANGRAAATVTPGAAGTTQVLEATDFDGDGRADLVVRTYRGESTDTIAVYPGVKGGALLAGEPQVTFSTAEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JP10</accession>
    <name>A0A2M9JP10_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Short-chain dehydrogenase/reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_28050</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000013">
        <property type="protein sequence ID" value="PJN08612.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08612">
        <property type="protein sequence ID" value="PJN08612"/>
        <property type="gene ID" value="CG723_28050"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN08612.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="284" mass="30599" checksum="02DB137C64E402DD" modified="2018-04-25" version="1">MPSQQPEQAATKVWFITGTSTGLGRSLAQEVIADGDRLIATARDPRTLDDLVALAPDRVRALPLDVTDPTTVRLAVDSALKEFGRIDVLVNNAGYALRGALEELSETELRRQFDTNVFGALDVTRAVLPALRAQRSGCIVQMSSVGGVMATLGGTAYAGTKFALEGLSEGLAAEVAHLGIHVLIVEPGPFRTDFTGRSVSYADPIDDYRPALDPAKEQFLAMHGIQPGDPSRAARAVITATRMEHPPLRLPLGANAIDRIRERLQQRLHEMDAIESLGRPTDFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JP14</accession>
    <name>A0A2M9JP14_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_28030</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000013">
        <property type="protein sequence ID" value="PJN08609.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08609">
        <property type="protein sequence ID" value="PJN08609"/>
        <property type="gene ID" value="CG723_28030"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021315">
        <property type="entry name" value="Gap/Sap"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11139">
        <property type="entry name" value="SfLAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="36"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="75"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="193"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="227"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN08609.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="260" mass="26352" checksum="FFA764E66DB2A4D4" modified="2018-04-25" version="1">MLLAKGAGHAADGALGTVPRGHSAASWAWSLEGEPVLIQAIGAVLPAALAVALSPFPLIGIVLILAGRQGRRNGLLFTAGWIAGLGIVATLVVVVFGGADDPESPSSAIADWGRVLAGVTLIVLGARKWWQRPGVGNETETPRWMASLEDVSALRALLLGALLSGANPKNLVLTASAATSIVEAGAHNGDLTVAVTVFVLVGSCTVLGAVIIHLLGGQRAASFLDSVRQFMITNSTVITAIVLLLLGASILGDGLTGLGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-05-25" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JPB6</accession>
    <name>A0A2M9JPB6_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">UPF0309 protein CG723_26415</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_26415</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0309 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000012">
        <property type="protein sequence ID" value="PJN08637.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08637">
        <property type="protein sequence ID" value="PJN08637"/>
        <property type="gene ID" value="CG723_26415"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097367">
        <property type="term" value="F:carbohydrate derivative binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901135">
        <property type="term" value="P:carbohydrate derivative metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05013">
        <property type="entry name" value="SIS_RpiR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01240">
        <property type="entry name" value="UPF0309"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035472">
        <property type="entry name" value="RpiR-like_SIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001347">
        <property type="entry name" value="SIS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046348">
        <property type="entry name" value="SIS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022951">
        <property type="entry name" value="UPF0309"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13580">
        <property type="entry name" value="SIS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53697">
        <property type="entry name" value="SSF53697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51464">
        <property type="entry name" value="SIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SIS" evidence="2">
        <location>
            <begin position="36"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN08637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="251" mass="26271" checksum="2764170F72204264" modified="2018-04-25" version="1">MSDSKLAGQYLDAAIGLLRRVRDEEDRNIAAAGTLIADTVAEGGRLFAFGAGHSSLAAQDVVYRAGGLALMNLLSVPGVVGVDVMPATLGSALERVDGLAGAVLDSSPVRAGDTLVIISLSGRNSLPVEMAMNARALGLRVIGVTSVAYAEETKSRHVSGTFLKDHCDIVLDSKIEVGDAELTYDTVDAPFGPASTMVASALMQATMATAAAELADRGIQPPLLRSGNVDGGHEWNGRVFSEYGDRIFYRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JPM5</accession>
    <name>A0A2M9JPM5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">N-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_27270</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000012">
        <property type="protein sequence ID" value="PJN08821.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08821">
        <property type="protein sequence ID" value="PJN08821"/>
        <property type="gene ID" value="CG723_27270"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="4"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN08821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="151" mass="17423" checksum="A23EDE38A1028D0F" modified="2018-04-25" version="1">MVRRMFRIETEVDKQRRDLLHFRLREANTAASAELRSLRGTPEEREVPLQVWALDESGEIAGGLDGHTWATWLHVNLLWVDDHHRAKGLGSRLLAEAERIAHEDRACHGARVETWDFQAPGFYRQHGYELVCVIPDYPPGIKEFTLTKRLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JPZ8</accession>
    <name>A0A2M9JPZ8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CG723_26065</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000011">
        <property type="protein sequence ID" value="PJN08951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08951">
        <property type="protein sequence ID" value="PJN08951"/>
        <property type="gene ID" value="CG723_26065"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PJN08951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="179" mass="18537" checksum="6D045C9C2B98CE90" modified="2018-04-25" version="1">MSDRTGNSTAASALPVAVDQGALLALADGHHARAVRPLGSGEHGGHLVKTYAIEAPGRAVTERDVAAVMPLVDAHLALGAVRGSLGLAVVLLHAGGDGDYVLVHTWIEGHMSDLAVLTGPVGHPELLRPGRTGLAPCVWEAAVLAHERTAFTRHVLDGEGPLVDRLAAWSADVTKEDAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JQ06</accession>
    <name>A0A2M9JQ06_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_26120</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000011">
        <property type="protein sequence ID" value="PJN08961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08961">
        <property type="protein sequence ID" value="PJN08961"/>
        <property type="gene ID" value="CG723_26120"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN08961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="77" mass="8241" checksum="64C357609CEB12AA" modified="2018-04-25" version="1">MTGFLDRAKEQAQRGLTQGKQKLDEVQAQRAGGDLLKKLGAAYYAERKGTGTPEATQSALGALENHIAEHGDGFLRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JQ89</accession>
    <name>A0A2M9JQ89_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CG723_24225</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000010">
        <property type="protein sequence ID" value="PJN09042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN09042">
        <property type="protein sequence ID" value="PJN09042"/>
        <property type="gene ID" value="CG723_24225"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PJN09042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="153" mass="16221" checksum="3FB7F7E7EECF9F71" modified="2018-04-25" version="1">MATVTPPPWTYALHLPHDPRAPGIARAALRVILDAHGLADLRDDAELLASELLTNAHLHTTGAYGLRLAPRSPGGVRVSVWDSSPEIPPGFHAGGISADAAQSGRGLHLVRACADAWGAYSLGTARRGKLLWAECRNEPTASTRLVSPHPHLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JQK9</accession>
    <name>A0A2M9JQK9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Cell division protein FtsK</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CG723_24795</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000010">
        <property type="protein sequence ID" value="PJN09135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN09135">
        <property type="protein sequence ID" value="PJN09135"/>
        <property type="gene ID" value="CG723_24795"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002543">
        <property type="entry name" value="FtsK_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01580">
        <property type="entry name" value="FtsK_SpoIIIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50901">
        <property type="entry name" value="FTSK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4" id="KW-0132">Cell division</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="133"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="162"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="187"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="domain" description="FtsK" evidence="3">
        <location>
            <begin position="352"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="373"/>
            <end position="380"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PJN09135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="705" mass="75965" checksum="2607913E1077A203" modified="2018-04-25" version="1">MSENVVHLHKDTEPTTEAATVTALTVVPDAAPAKPVPLWVRSGRAIRTAVTHETTRTTARAVARHGLYTVNGGRIVARRAWDGKTGARYERMLRAAEAAGNFEVAEEWEDRLQRFREARHRRRMDLLHSPVDAAKGVAVGAGMSVGVLVTLGVVMAINNHDIGDVITPLAAVIEFIGLLIRIVQVVWGPALTIGPFLALLALWAVGSKQQAAPAWALPDNIRSDEGEPITPSIVVKALRDLGVPALRNAIKEMGDAGAGMLGPIRIAGCGVEVDVTLPSGVSTIEVQNRRRKLAENLTRHEHEVFITIPQAARTVRLWVADSGALDEPIGPSPLVTDDTMTADYSKGRAPWGQDLRGDAAALSLYQRHLLITGLSNQGKTVALRSLALWLALDKSVQFLMGDLKGVGDWAMFDGLATTLIQGPTDEHVIQVTEMVEGAVDEMNRRLMAPPGTVFPALIVLVDEAQVAFMCPLKDEDGRFYGGSKATSRYFMAVRKIHNQGRAVNVLMWQGTQDPTDQNLPKLVREGAHTRASLALGTESQARMALGDKAVDGGAAPNLLRPGLDQGTLVVASSGIDIPKGQSSITVRTHYVDDDGAEAITDRAKAMRDGVTTLHVIERGEERDPLRDIFSVLGDASRVLTQDVLKRLAALNQDAYGKWSFIDLKRVLDGTGAEPYKSDGRMVVGRDRVARALTNQGNEGSASASE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JR16</accession>
    <name>A0A2M9JR16_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF397 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_24215</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000010">
        <property type="protein sequence ID" value="PJN09227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN09227">
        <property type="protein sequence ID" value="PJN09227"/>
        <property type="gene ID" value="CG723_24215"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007278">
        <property type="entry name" value="DUF397"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04149">
        <property type="entry name" value="DUF397"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF397" evidence="1">
        <location>
            <begin position="5"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN09227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="61" mass="6396" checksum="2A33E517B32FA469" modified="2018-04-25" version="1">MTDLNWQKSSYCAEGNSCVHVAKDTGAVHVTESADPSRAILSTAPSAFAALLQALKAKPHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JR24</accession>
    <name>A0A2M9JR24_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">6-phosphogluconate dehydrogenase (Decarboxylating)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">gnd</name>
        <name evidence="4" type="ORF">CG723_23555</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CB01635</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 6-phosphogluconate dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000009">
        <property type="protein sequence ID" value="PJN09325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN09325">
        <property type="protein sequence ID" value="PJN09325"/>
        <property type="gene ID" value="CG723_23555"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004616">
        <property type="term" value="F:phosphogluconate dehydrogenase (decarboxylating) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019521">
        <property type="term" value="P:D-gluconate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016054">
        <property type="term" value="P:organic acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006098">
        <property type="term" value="P:pentose-phosphate shunt"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004849">
        <property type="entry name" value="6DGDH_YqeC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006114">
        <property type="entry name" value="6PGDH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006115">
        <property type="entry name" value="6PGDH_NADP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006183">
        <property type="entry name" value="Pgluconate_DH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11811">
        <property type="entry name" value="PTHR11811"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00393">
        <property type="entry name" value="6PGD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03446">
        <property type="entry name" value="NAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00076">
        <property type="entry name" value="6PGDHDRGNASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01350">
        <property type="entry name" value="6PGD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="SSF48179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00872">
        <property type="entry name" value="gnd_rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0311">Gluconate utilization</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="6PGD" evidence="3">
        <location>
            <begin position="190"/>
            <end position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008419"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM01350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PJN09325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="343" mass="36651" checksum="4930F40DCF6229B1" modified="2018-04-25" version="1">MATDKPMQLGMIGLGRMGANLVRRLMRDGHHCVVSDVNAAAVAELAGEGATGADSLQDFVAKLDKPRAVWLMLPAAIVDSILDQLEPLLEPGDILIDGGNSYYRDDITRAKRLADKSLHYVDCGTSGGVWGLERGYCLMIGGEDETVAHLDPIFKTIAPGEGCAEPTPSRTRTDGTAPLGYLHCGPNGAGHFVKMVHNGVEYGMMAAIAEGLSIIKRADAGTSRQEVDAETTPLRDPWAYQYDIDVGEVAEVWRRGSVVGSWLVDLIADAFAGSPSLDGFAGRVSDSGEGRWTVLAAVDEGVPVPVITTSLYERFESRQAGEFTDKILSAMRSEFGGHAEKKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JR57</accession>
    <name>A0A2M9JR57_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Pyridine nucleotide-disulfide oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CG723_23735</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CB01635</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="2">Binds 1 FAD per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000009">
        <property type="protein sequence ID" value="PJN09348.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN09348">
        <property type="protein sequence ID" value="PJN09348"/>
        <property type="gene ID" value="CG723_23735"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045454">
        <property type="term" value="P:cell redox homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016156">
        <property type="entry name" value="FAD/NAD-linked_Rdtase_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001100">
        <property type="entry name" value="Pyr_nuc-diS_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004099">
        <property type="entry name" value="Pyr_nucl-diS_OxRdtase_dimer"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02852">
        <property type="entry name" value="Pyr_redox_dim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000350">
        <property type="entry name" value="Mercury_reductase_MerA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55424">
        <property type="entry name" value="SSF55424"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="2" id="KW-0520">NAD</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyr_redox_2" evidence="5">
        <location>
            <begin position="8"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="domain" description="Pyr_redox_dim" evidence="4">
        <location>
            <begin position="364"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="54"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="117"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="184"/>
            <end position="191"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="274"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="316"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="disulfide bond" description="Redox-active" evidence="3">
        <location>
            <begin position="45"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000350-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000350-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PJN09348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="479" mass="50962" checksum="BF474117F731544F" modified="2018-04-25" version="1">MHGTTRTYDVIVIGAGPVGENVAERARAAGLSTVIIERDLLGGECSFWACDPSKALLRPVVARADASRIPGLNPAVAGPLDVEAVLAHRDKMSSYWKDEDQVDWLNSVSVDLIRGHGRLTGPKQVAVQTPEGDTIVLTARHAVAVSTGTRAALPPIPGFDTVRPWTSREATSADKVPGRLAVVGGGVVAVEMATAWQALGSQVTMFVLENGLLERMEPFAGELVTDGLREAGVDIRFNTTVTSLAREGGEDDEVRITLSDGTQLAADEILLATGRAPQTRDIGLESVGLTPGDWLTVDDTFRVTGVEGGWLYAVGDVNRRALMTHQGKYQARIAGTVIGARAKGEPIDDAPWGPHAATADHAAVPQVVFTTPEVASVGLTSREAEQSGRRIEVVDYDLARVAGAHQYGEDYRGRVRMLVDTDRNTVAGVTFAGPGVGELVHSATIAVAGEVPLDRLWHAVPAFPTLGEVWLRLLETYRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JRR2</accession>
    <name>A0A2M9JRR2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Amino acid permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CG723_22580</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CB01635</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000008">
        <property type="protein sequence ID" value="PJN09532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN09532">
        <property type="protein sequence ID" value="PJN09532"/>
        <property type="gene ID" value="CG723_22580"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="40"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="72"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="114"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="161"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="190"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="231"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="269"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="319"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="365"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="393"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="438"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="479"/>
            <end position="499"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PJN09532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="523" mass="54465" checksum="D9FB8F5CAF1156C7" modified="2018-04-25" version="1">MTVTTDSTTPPPPPSAGVTDDGTLATFGYRQELRRQMGRYASFAAGFSFISVLTTVFQFFSLGYSFGGPLFLWTWPAVLIGQLLVAACFAELAARYPISGAIFQWSTRLSRPAFGWFTGWIMVIGQVVVVAAAALALQVVLPPIWSGFQLVGGDPAPTTATGAANAALLALVLLALTTAVNVLDNRVMSAVNRIGVTAEIIGAILIVVLLFTHVERGAGVALKTGGQDGTVAALLVGSFTAAYVLIGFDSAGEMSEETRNPRRTAPRTILSALATAGALGGLLLLGGLLAAPSLSDGHLATEGLSYVLTSSLGDGVGKVLLADVAVAVSVATLAIQTAGSRMLFSMARDGMLPFSARLAKVSPRTGMPFVPALVVGGLAAALALLNLASPEAFVAIGTTCIAMLYLAYLGVTAPMLLRRLKGQWPTTDSGDRDELGRPLFSLGRWGLPVNALAVVYGLFMTVNLSWPRAQVYDPAGGHWYFQWFTVLFVGATVAAGAVYRSRAGVAPAAKGPGRKEPAEAVRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-05-25" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JS05</accession>
    <name>A0A2M9JS05_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">L-glutamate gamma-semialdehyde dehydrogenase</fullName>
            <ecNumber evidence="3">1.2.1.88</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">L-glutamate gamma-semialdehyde dehydrogenase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">pruA</name>
        <name evidence="10" type="ORF">CG723_20810</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CB01635</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>H2O + L-glutamate 5-semialdehyde + NAD(+) = 2 H(+) + L-glutamate + NADH</text>
            <dbReference type="Rhea" id="RHEA:30235"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:58066"/>
            <dbReference type="EC" id="1.2.1.88"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid degradation; L-proline degradation into L-glutamate; L-glutamate from L-proline: step 2/2.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.88" evidence="3"/>
    <dbReference type="EMBL" id="NNBL01000007">
        <property type="protein sequence ID" value="PJN09656.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN09656">
        <property type="protein sequence ID" value="PJN09656"/>
        <property type="gene ID" value="CG723_20810"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00261">
        <property type="reaction ID" value="UER00374"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003842">
        <property type="term" value="F:1-pyrroline-5-carboxylate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016620">
        <property type="term" value="F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010133">
        <property type="term" value="P:proline catabolic process to glutamate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd07123">
        <property type="entry name" value="ALDH_F4-17_P5CDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016160">
        <property type="entry name" value="Ald_DH_CS_CYS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005931">
        <property type="entry name" value="P5CDH/ALDH4A1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="SSF53720"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01236">
        <property type="entry name" value="D1pyr5carbox1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00070">
        <property type="entry name" value="ALDEHYDE_DEHYDR_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-0642">Proline metabolism</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldedh" evidence="9">
        <location>
            <begin position="56"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="active site" evidence="7">
        <location>
            <position position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00032259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PJN09656.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="543" mass="58552" checksum="3AA4883C68E59F38" modified="2018-04-25" version="1">MDAVTQVPAPVNEPVHGYAPGSPERARLEVKLKELAENPIELSMTIGGVKRLGGGDEFTVVQPHNHQAVIGTGRGATQADAQDAIDAALAAAPAWRAMSFDDRAAIILRAAELLSTTWRETLAASTMLGQSKTAQQAEIDTPCELVDFWRFNVHYARNILAEQPPANSTGVWNRMDHRPLEGFVYAITPFNFTAIAGNLPTAPALMGNVVVWKPSPTQTHAAVLLMQLLEEAGLPKGVINLVTGDGIAVSEVALNHRDLAGIHFTGSTKTFQHLWKTVGTNIDKYRTYPRLVGETGGKDFVVAHPSADRAVLKTALTRGSFEYQGQKCSASSRAYVPASIWNDGFKEEFAAEVDGIKMGDVTDLTNFIGAVIDERSFAKNKAAIDRAKSDPTCTVIAGGEYDDSVGYFVRPTVIVCSDPANEVFTTEYFGPILAVHVYDDAKYDEMLDQMESASDYALTGAVISNDRAAAAHTMDKLRYAAGNFYINDKSTGAVVGQQPFGGGRASGTNDKAGAPQNLQRWTLTRAIKETLVPPTEYGYPHMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JS28</accession>
    <name>A0A2M9JS28_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">3-isopropylmalate dehydratase large subunit</fullName>
            <ecNumber evidence="14">4.2.1.33</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Alpha-IPM isomerase</fullName>
            <shortName evidence="14">IPMI</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="14">Isopropylmalate isomerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14 17" type="primary">leuC</name>
        <name evidence="17" type="ORF">CG723_21030</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">CB01635</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3 14">Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 14">
            <text>(2R,3S)-3-isopropylmalate = (2S)-2-isopropylmalate</text>
            <dbReference type="Rhea" id="RHEA:32287"/>
            <dbReference type="ChEBI" id="CHEBI:1178"/>
            <dbReference type="ChEBI" id="CHEBI:35121"/>
            <dbReference type="EC" id="4.2.1.33"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(2S,3R)-3-hydroxybutane-1,2,3-tricarboxylate = 2-methyl-cis-aconitate + H2O</text>
            <dbReference type="Rhea" id="RHEA:17941"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:57429"/>
            <dbReference type="ChEBI" id="CHEBI:57872"/>
            <dbReference type="EC" id="4.2.1.99"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="14">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="14">Binds 1 [4Fe-4S] cluster per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4 14">Amino-acid biosynthesis; L-leucine biosynthesis; L-leucine from 3-methyl-2-oxobutanoate: step 2/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="5">Organic acid metabolism; propanoate degradation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="14">Heterodimer of LeuC and LeuD.</text>
    </comment>
    <comment type="similarity">
        <text evidence="14">Belongs to the aconitase/IPM isomerase family. LeuC type 1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.33" evidence="14"/>
    <dbReference type="EMBL" id="NNBL01000007">
        <property type="protein sequence ID" value="PJN09690.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN09690">
        <property type="protein sequence ID" value="PJN09690"/>
        <property type="gene ID" value="CG723_21030"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00048">
        <property type="reaction ID" value="UER00071"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00946"/>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047456">
        <property type="term" value="F:2-methylisocitrate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003861">
        <property type="term" value="F:3-isopropylmalate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009098">
        <property type="term" value="P:leucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01583">
        <property type="entry name" value="IPMI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.499.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01026">
        <property type="entry name" value="LeuC_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004430">
        <property type="entry name" value="3-IsopropMal_deHydase_lsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015931">
        <property type="entry name" value="Acnase/IPM_dHydase_lsu_aba_1/3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001030">
        <property type="entry name" value="Acoase/IPM_deHydtase_lsu_aba"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018136">
        <property type="entry name" value="Aconitase_4Fe-4S_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036008">
        <property type="entry name" value="Aconitase_4Fe-4S_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033941">
        <property type="entry name" value="IPMI_cat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00330">
        <property type="entry name" value="Aconitase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00415">
        <property type="entry name" value="ACONITASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53732">
        <property type="entry name" value="SSF53732"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00170">
        <property type="entry name" value="leuC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00450">
        <property type="entry name" value="ACONITASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01244">
        <property type="entry name" value="ACONITASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 14" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="8 14" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="13 14" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="10 14" id="KW-0408">Iron</keyword>
    <keyword evidence="11 14" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="6 14" id="KW-0432">Leucine biosynthesis</keyword>
    <keyword evidence="12 14" id="KW-0456">Lyase</keyword>
    <keyword evidence="9 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aconitase" evidence="16">
        <location>
            <begin position="7"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="418"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="420"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="347"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="407"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="410"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00000491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00002695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00005026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF00330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="PJN09690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="476" mass="50450" checksum="1621FF85572BCE2A" modified="2018-04-25" version="1">MGRTLAEKVWDDHVVRRAEGEPDLLFIDLHLLHEVTSPQAFDGLRQTGRQVRRLDLTIATEDHNTPTLDIDKPIADPVSRAQLETLRKNCADFGVRLHSLGDVEQGVVHVVGPQLGLTQPGTTVVCGDSHTSTHGAFGALAFGIGTSQVEHVLATQTLPLARPRTMAITVDGELPEGVTAKDLILAIIAKIGTGGGQGYILEYRGSAIEKLSMEARMTICNMSIEAGARAGMIAPDEITFAYLEGRAHAPKGEDWDAAVAYWKTLKSDDDAEFDAEVVIDAAALAPFVTWGTNPGQGSPLSAHVPDPASYEDASERHAAERALEYMGLTAGQPLRDIKVDTVFVGSCTNGRIEDLRAVAEIVGGRQVADGVRMLVVPGSARVGLQAVSEGLDKVFKEAGAEWRHAGCSMCLGMNPDQLAPGERSASTSNRNFEGRQGKGGRTHLVSPQVAAATAVLGHLASPADLSDTDARTPAGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JS47</accession>
    <name>A0A2M9JS47_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Cytochrome bc1 complex cytochrome b subunit</fullName>
            <ecNumber evidence="2">7.1.1.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Cytochrome bc1 reductase complex subunit QcrB</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CG723_20905</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CB01635</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a quinol + 2 Fe(III)-[cytochrome c](out) = a quinone + 2 Fe(II)-[cytochrome c](out) + 2 H(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:11484"/>
            <dbReference type="Rhea" id="RHEA-COMP:10350"/>
            <dbReference type="Rhea" id="RHEA-COMP:14399"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
            <dbReference type="EC" id="7.1.1.8"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.1.1.8" evidence="2"/>
    <dbReference type="EMBL" id="NNBL01000007">
        <property type="protein sequence ID" value="PJN09672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN09672">
        <property type="protein sequence ID" value="PJN09672"/>
        <property type="gene ID" value="CG723_20905"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008121">
        <property type="term" value="F:ubiquinol-cytochrome-c reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022904">
        <property type="term" value="P:respiratory electron transport chain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.810.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005797">
        <property type="entry name" value="Cyt_b/b6_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027387">
        <property type="entry name" value="Cytb/b6-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016174">
        <property type="entry name" value="Di-haem_cyt_TM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13631">
        <property type="entry name" value="Cytochrom_B_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81342">
        <property type="entry name" value="SSF81342"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51002">
        <property type="entry name" value="CYTB_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-1278">Translocase</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="51"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="123"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="154"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="186"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="219"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="265"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="334"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="384"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="415"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="domain" description="CYTB_NTER" evidence="9">
        <location>
            <begin position="25"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="521"/>
            <end position="547"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012951"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00029351"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00029568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PJN09672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="547" mass="61324" checksum="2743335D7AF094A8" modified="2018-04-25" version="1">MSERAAEGSTGTARERGPAPAGERLADWADGRLGLHTLSRKYLRKVFPDHWSFLLGEVCLYTFVILVLTGVYLTLFFHPSMNEVEYHGSYVPLNGIRMSEAYASTLDISFDVRGGLLIRQIHHWAALIFVAAMLLHMMRHFFTGSFRKPRELNWVFGWTLLLLGLFEGLLGYSLPDDLLSGTGMRFLDGAILSVPVVGTYLSMFLFGGEFPGHDIVGRFYSVHVLLFPGIMAALVVTHLILVVYHKHTQFPGPGKTERNVVGAPFFPVYLAKAGGFFFLVFGVVAFLAAVASINPVWNYGPYRVDQVSTGAQPDWYLGFAEGLLRVMPGWEITLWGHTLALGVLVPLVVFPAVLVVIGVYPYLEAWVTGDRREHHLLDRPRNRPVRTGLGVAWLTFFLVALVGGGNDLWATRFHVALNAVTWFVRVALLIGPVITFVITRRICLGLQRRDRELVLHGRESGRIKRLPHGEYVEIHEPLTQAQLHILTAHEQPPALESGPETDVNGVRRRIPRAERLRVRLSRGLHGEGAQVPKPTAREYEEAQREHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JS52</accession>
    <name>A0A2M9JS52_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Glycerol-3-phosphate dehydrogenase [NAD(P)+]</fullName>
            <ecNumber evidence="7">1.1.1.94</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">NAD(P)H-dependent glycerol-3-phosphate dehydrogenase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">gpsA</name>
        <name evidence="16" type="ORF">CG723_21060</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">CB01635</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>NAD(+) + sn-glycerol 3-phosphate = dihydroxyacetone phosphate + H(+) + NADH</text>
            <dbReference type="Rhea" id="RHEA:11092"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57597"/>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.94"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7 12">
            <text>NADP(+) + sn-glycerol 3-phosphate = dihydroxyacetone phosphate + H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:11096"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57597"/>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.94"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="7 13">Membrane lipid metabolism; glycerophospholipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7 13">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7 11">Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.94" evidence="7"/>
    <dbReference type="EMBL" id="NNBL01000007">
        <property type="protein sequence ID" value="PJN09694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN09694">
        <property type="protein sequence ID" value="PJN09694"/>
        <property type="gene ID" value="CG723_21060"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00940"/>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009331">
        <property type="term" value="C:glycerol-3-phosphate dehydrogenase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004367">
        <property type="term" value="F:glycerol-3-phosphate dehydrogenase [NAD+] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046167">
        <property type="term" value="P:glycerol-3-phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046168">
        <property type="term" value="P:glycerol-3-phosphate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006650">
        <property type="term" value="P:glycerophospholipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00394">
        <property type="entry name" value="NAD_Glyc3P_dehydrog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006168">
        <property type="entry name" value="G3P_DH_NAD-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006109">
        <property type="entry name" value="G3P_DH_NAD-dep_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011128">
        <property type="entry name" value="G3P_DH_NAD-dep_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07479">
        <property type="entry name" value="NAD_Gly3P_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01210">
        <property type="entry name" value="NAD_Gly3P_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000114">
        <property type="entry name" value="Glycerol-3-P_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00077">
        <property type="entry name" value="GPDHDRGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="SSF48179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00957">
        <property type="entry name" value="NAD_G3PDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 7" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="4 7" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7 10 11" id="KW-0520">NAD</keyword>
    <keyword evidence="3 7 11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5 7 13" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="6 7" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD_Gly3P_dh_N" evidence="14">
        <location>
            <begin position="7"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="domain" description="NAD_Gly3P_dh_C" evidence="15">
        <location>
            <begin position="183"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="7 9">
        <location>
            <begin position="258"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="7 8">
        <location>
            <position position="194"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7 10">
        <location>
            <begin position="11"/>
            <end position="16"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7 9">
        <location>
            <position position="109"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7 10">
        <location>
            <position position="143"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7 10">
        <location>
            <position position="258"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="284"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000114-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000114-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000114-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU004280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF01210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF07479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="PJN09694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="336" mass="34840" checksum="25D5FEBA260012FD" modified="2018-04-25" version="1">MTPPVKAAVFGTGSWGTAFAMVLADAGCDVTLWARRPGLAEAVNSTRTNPDYLPGIELPGNIRATTDAAAAADGAEFTVLAVPSQTLRANLAEWTPLLAPGTVLVSLMKGVELGSAMRMSEVIEDVTKVGEDRIAIVTGPNLAREIAARMPAAAVVACSDESVAQRLQTACHTPYFRPYTNTDVIGCELGGAVKNVIGLAVGIADGMGLGDNAKGSLITRGLAETTRLGLAMGADPLTFSGLAGLGDLVATCSSPLSRNHTFGTNLGKGMTLQETIAVTKQTAEGVKSCESVLDLARRHGVDMPITETVVGIVHEGKSPVVALKEMMSRSAKPERR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JSR4</accession>
    <name>A0A2M9JSR4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_19405</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000006">
        <property type="protein sequence ID" value="PJN09910.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN09910">
        <property type="protein sequence ID" value="PJN09910"/>
        <property type="gene ID" value="CG723_19405"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="142"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="92"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="170"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="265"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="186"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="265"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="315"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="358"/>
            <end position="381"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN09910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="381" mass="38811" checksum="E32255FC11C59463" modified="2018-04-25" version="1">MADEHNKWLDRDAAERLLRGEPLEAVDAATRARAARLAETLDALAVTRVEGGELRGEAAALAAFRKARESVAEEPGAAPLKARHARPRGALAPVSSLHGPVGRESDANANAGADGHAAADVGSVRLARPDARPVRWGRPVRFGLAAAFAGCMIGGVAVAAGTGVLPSPFGGRNEPGPAASVSAAASPEQPLASPSPDISETDGGRSGSAVPDGHSHEPGSGAPSQDDTADRAGPATTRPGTGLRESDAADREAWRQRLVDACRKYRDGALSDSQTERLRAAAKRIATKKRDRDPDRFCARILEEADDSGSGDDGSGQDGDDKNGGKNGDEDSQNGEDSGVSGAVPTASWVPSEPGGDASDTAPTTPSTTASASYSAAPAQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-06-02" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JSZ8</accession>
    <name>A0A2M9JSZ8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Alkylhydroperoxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_19690</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000006">
        <property type="protein sequence ID" value="PJN09952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN09952">
        <property type="protein sequence ID" value="PJN09952"/>
        <property type="gene ID" value="CG723_19690"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004601">
        <property type="term" value="F:peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051920">
        <property type="term" value="F:peroxiredoxin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029032">
        <property type="entry name" value="AhpD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004675">
        <property type="entry name" value="AhpD_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003779">
        <property type="entry name" value="CMD-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02627">
        <property type="entry name" value="CMD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69118">
        <property type="entry name" value="SSF69118"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00778">
        <property type="entry name" value="ahpD_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CMD" evidence="2">
        <location>
            <begin position="39"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02627"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN09952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="180" mass="20177" checksum="D889FA22A6F936DC" modified="2018-04-25" version="1">MTTNENTTDSTRPTTDAGRTTKEYVHEHAPRLAWAKHAPEVYKAMIRLDAEARKGVDPVTLELVKIRASQINHCAFCLDMHSKDALAAGESVERIIQLAAWEESQHFYTPREIAAIELTEAITVLTDGFVPDETYEKAAKLYDEKELTQLIAAITVINAWNRFGVSTRMVPGHYTAGDFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JT28</accession>
    <name>A0A2M9JT28_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9 10">Protein translocase subunit SecY</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">secY</name>
        <name evidence="13" type="ORF">CG723_20225</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">CB01635</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9 10">The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of the Sec protein translocase complex. Heterotrimer consisting of SecY, SecE and SecG subunits. The heterotrimers can form oligomers, although 1 heterotrimer is thought to be able to translocate proteins. Interacts with the ribosome. Interacts with SecDF, and other proteins may be involved. Interacts with SecA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cell membrane</location>
            <topology evidence="9">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 11">Membrane</location>
            <topology evidence="1 11">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9 12">Belongs to the SecY/SEC61-alpha family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000006">
        <property type="protein sequence ID" value="PJN10046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN10046">
        <property type="protein sequence ID" value="PJN10046"/>
        <property type="gene ID" value="CG723_20225"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0065002">
        <property type="term" value="P:intracellular protein transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006605">
        <property type="term" value="P:protein targeting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043952">
        <property type="term" value="P:protein transport by the Sec complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3370.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01465">
        <property type="entry name" value="SecY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026593">
        <property type="entry name" value="SecY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002208">
        <property type="entry name" value="SecY/SEC61-alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030659">
        <property type="entry name" value="SecY_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023201">
        <property type="entry name" value="SecY_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10906">
        <property type="entry name" value="PTHR10906"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00344">
        <property type="entry name" value="SecY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004557">
        <property type="entry name" value="SecY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103491">
        <property type="entry name" value="SSF103491"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00967">
        <property type="entry name" value="3a0501s007"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00755">
        <property type="entry name" value="SECY_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00756">
        <property type="entry name" value="SECY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 9 11" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 9 11" id="KW-0811">Translocation</keyword>
    <keyword evidence="4 9 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 9 11" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="18"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="68"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="116"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="156"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="190"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="215"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="276"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="317"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="378"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="402"/>
            <end position="420"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005751"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000537"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU004349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PJN10046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="437" mass="47385" checksum="7B25DB0CB9C55473" modified="2018-04-25" version="1">MLTAFARAFKTPDLRKKLLFTLGIIVIYRMGTHVPIPGVSYSNVQTCVDANKGTQGLFGLVNMFSGGALLQITIFALGIMPYITASIILQLLTVVIPRLEALKKEGQAGTAKITQYTRYLTVALAILQGTGLVATARSGALFQGCPVANQIVPDQSIFVTITMVITMTAGTAIVMWLGELITDRGIGNGMSILMFISIAATFPSALWTIKTTGDLAGGWIEFGAVILVGLVMVGLVVFVEQAQRRIPVQYAKRMIGRRSYGGTSTYIPLKVNQAGVIPVIFASSLLYIPALVAQFAGGNSGWKTWINDHLTKGNHPYYIVSYFLLIVFFAFFYVAISFNPEEVADNMKKYGGFIPGIRAGRPTAEYLSYVLNRITWPGSLYLGLIALVPTMALVGFGASQNFPFGGTSILIIVGVGLETVKQIESQLQQRNYEGFLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JU10</accession>
    <name>A0A2M9JU10_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alpha/beta hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_18545</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000005">
        <property type="protein sequence ID" value="PJN10370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN10370">
        <property type="protein sequence ID" value="PJN10370"/>
        <property type="gene ID" value="CG723_18545"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00111">
        <property type="entry name" value="ABHYDROLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="22"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN10370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="279" mass="29807" checksum="C576C2D54E547C57" modified="2018-04-25" version="1">MPAFTAPDGTRLAYHVVGEGEPLICLPGGPMRASAYLGDLGGLAKRRRLVLLDLRGTGDSDVPADPSTYRCDRQVGDVEALRVQLGLESVDLLAHSAAGDLALLYAARYPRRVRTLTMVTARARALGVDFTTDQRLEAADLRADEPWFVSARDALGRVWDGTATDEDFDAAVPFFYGRWDAAAEAHAAGEVEQTNEEAADVYASPGSFDPAAARAALAGWDARVLVLAGERDGGPLPRVAAAIAELFPRAQLVVQDGAGHFPWVDDPDRFTETVASFLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JU48</accession>
    <name>A0A2M9JU48_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">XRE family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_18825</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000005">
        <property type="protein sequence ID" value="PJN10415.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN10415">
        <property type="protein sequence ID" value="PJN10415"/>
        <property type="gene ID" value="CG723_18825"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013096">
        <property type="entry name" value="Cupin_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07883">
        <property type="entry name" value="Cupin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01381">
        <property type="entry name" value="HTH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="17"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN10415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="197" mass="21735" checksum="B52D4159BEA25BF0" modified="2018-04-25" version="1">MSDDEFTPVLAGVGPRLRALRNERGTTLARLSEQTGISLSTLSRLESGQRKPTLELLLPLAKAHHVALDELVGAPDTGDPRIHPRPITRNGHTYIPLTRHLGGLHAYKQIMPVRELGEGVRPEQNTHEGYEWLYVLTGRLHLALGEYDLILTAGEAAEFDTRTPHGFANAGTYPVEFLSLFGPQGERLHVRARPSEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JV57</accession>
    <name>A0A2M9JV57_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_16375</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000004">
        <property type="protein sequence ID" value="PJN10760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN10760">
        <property type="protein sequence ID" value="PJN10760"/>
        <property type="gene ID" value="CG723_16375"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045063">
        <property type="entry name" value="Dynamin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005662">
        <property type="entry name" value="GTP-bd_Era"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42698">
        <property type="entry name" value="PTHR42698"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00350">
        <property type="entry name" value="Dynamin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dynamin_N" evidence="1">
        <location>
            <begin position="66"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN10760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="537" mass="57843" checksum="AE6488C34621E350" modified="2018-04-25" version="1">MVTLDVRPQLLDALSALRDRVAAARFPLPLPGAPRARANRVELLAQLDDYLVPRLKDPEAPLLAVIGGSTGAGKSTLVNSLVGRKVSEAGVLRPTTRTPVLVCHPEDHRWFSGARVLPDLTRVWTPRRPDDIELGAAAPADDDEHVLRVETSGNLPRGLALLDAPDVDSLVARNRVLAAQLISAADVWIMVTTASRYADAVPWHLLRSAKENNATLVTVLDRVPHQMVAEVSRQYGALLAKAGLGDVPRFTVPELPESTGGGGLLPATAVAPLRAWLSHRVQDPTARCAAIARTANGVIDSLRVRTPGLAGAVASQYAAALRLTAIVDETYAREHARVRTRLQSGGVLAGDALKRWRSYPLDCAPVELLDALTESLGALLLCAVTAADEHIDDAWHRDPGGAADGLADRDPDLETAEHRIGMAVRRWRRMLEEYAEEQVRTLDTTPPPDTELVAALLATALLGGNRARSAGESLAERIGAQGALRLRDRGGRLLTEYLDKVLAVERDRRLAPLDALDVQPESQAELIAALSVLQKER</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JVY3</accession>
    <name>A0A2M9JVY3_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SseB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_08475</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN11019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN11019">
        <property type="protein sequence ID" value="PJN11019"/>
        <property type="gene ID" value="CG723_08475"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009839">
        <property type="entry name" value="SseB_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07179">
        <property type="entry name" value="SseB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SseB" evidence="1">
        <location>
            <begin position="17"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN11019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="138" mass="14712" checksum="8B6B9B5131F560A5" modified="2018-04-25" version="1">MCDDSIPKELFAAAAQDALRDLHQAPDDLAALDTLAACDILVPEPTELGTHDHPEEGGLTLPVIDDPPRLRAVPVFTSAERMGQALPDVVVSHQIQLGLLAANWPTDEDLALLIDPGHHDGVILTSRGVRALLAPPRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JW07</accession>
    <name>A0A2M9JW07_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CG723_08850</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN11071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN11071">
        <property type="protein sequence ID" value="PJN11071"/>
        <property type="gene ID" value="CG723_08850"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="6"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="250"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="38"/>
            <end position="45"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PJN11071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="513" mass="55349" checksum="F6EDA5FF4FD427BD" modified="2018-04-25" version="1">MSEVLLEARGIVKVFPGVRALDGVRLRLEAGTVHALLGENGAGKSTLIKVLTGVHPPDGGQLLLHGEGVRFRSPLEAAHAGIGVVHQERNLVPAFSVAENICLQAPPSRRGMIDREAMSAPALRCLAEIGVELDPQTPVSRLSVAQKQLVEIAKALFTESRVLLLDEPTASLSPQETERLFGVIRRLADRGTCVVFVSHKLEEVFAVCDTVTVLRDGQSVLGSAPLADHTHDDVVNLMVGRAHTTSGFTSRTVDTTSPPALSLSGFSTGAGHRDITLDVRVGEIVGLYGLVGAGRSELAKAILGLDRIESGEVRVHGAPVRINSPRQALHEHGIGYVTENRKEEGVFLEQPIVRNITVTVWRKLARALGYVPADRERATAAELVEQLGIRISGLDQPAGELSGGNQQKVSLAKWLAADTRLLVVDEPTVGVDIRTKRAFHELLWELAGKGLAILLISSDLGEMVTLADRIVVMGGYRTRGEVQNDHDYEEMSGRIIRLIHGRSEEAVHERNTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JWF6</accession>
    <name>A0A2M9JWF6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CG723_09795</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CB01635</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN11226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN11226">
        <property type="protein sequence ID" value="PJN11226"/>
        <property type="gene ID" value="CG723_09795"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="21"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="88"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="121"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="150"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="201"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="258"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="90"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="306"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PJN11226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="330" mass="34606" checksum="BD69A4838F8D41F6" modified="2018-04-25" version="1">MSASVRRKRSLRRLKLPPNPKVRIGIAIFVFFALLALLGPFVVQNVMGLSPSDVDTAQAMELPSAEHLLGTTATGEDVFAQLVVGSRISLLVGLVAGVITTTLSVLVGVAGGYLGGRADSFLTAATNVCLVIPGMPLLIIVASYVQGRGGWLTVALVIGLTAWPWGARQKRAQTLSLRHRDFVSAAEMTGESRWGVITRELIPSLAPIISVSFLGAVVGSMFADAGLSFMGLGNINITSWGSMLYWAQNAGALTRGAWWWFVPPGACIALIGVAAGLINFGIDEISNPRLRKPSKEVRARARAARLHAAAGDSAGKATAGKPAPVQEAAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JWH9</accession>
    <name>A0A2M9JWH9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Deaminase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_10015</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN11261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN11261">
        <property type="protein sequence ID" value="PJN11261"/>
        <property type="gene ID" value="CG723_10015"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008703">
        <property type="term" value="F:5-amino-6-(5-phosphoribosylamino)uracil reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009231">
        <property type="term" value="P:riboflavin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.430.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024072">
        <property type="entry name" value="DHFR-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002734">
        <property type="entry name" value="RibDG_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01872">
        <property type="entry name" value="RibD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53597">
        <property type="entry name" value="SSF53597"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RibD_C" evidence="1">
        <location>
            <begin position="3"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN11261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="201" mass="22074" checksum="CAFBC6DBB1ACA995" modified="2018-04-25" version="1">MGKIVISENVSLDGVVQDPTGEEGFRHGGWFGRMADKDRLEWTKVEFDEALGTAALLLGRRSYEWFAAWWPSRSGAWAERLNTLPKYVVSSTLVDPEWNNSTVLDGEVVPEVSKLKQEVDGDIVVYASRRLVRTLLAHGLADELRLIVHPVVLGAGERLFGETGDGLSLRLLDTRTVGDSLAALTYGIVRDAQGQAPSLDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JWK7</accession>
    <name>A0A2M9JWK7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">FAD-binding molybdopterin dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_10030</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN11263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN11263">
        <property type="protein sequence ID" value="PJN11263"/>
        <property type="gene ID" value="CG723_10030"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002346">
        <property type="entry name" value="Mopterin_DH_FAD-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00941">
        <property type="entry name" value="FAD_binding_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="SSF56176"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="1">
        <location>
            <begin position="1"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN11263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="275" mass="30048" checksum="BF979726EE513E47" modified="2018-04-25" version="1">MDLNTVTEVVRRPLDPPGADWREGDAWLAGGTWLFSVEQPSLRRLVDLTALRWEPLLPGRAGLEIGATCTIRDLHSFAFPGDWIAGTLLAKSCDAFLSSFKVWNSATVGGNICLSLPAGPMITLTVALEGRYELWASDGSTRTVDALDFVTGDHQNVLGPGEVLRRIDIPARALRKRAAHRRFSLTRLGRSTVFVVGTRTPGTSDLLLTVTAGTTRPVRIAFDTMPDASALRRSIDAVPSGLWFSDANGTPDHRRHLTKHFAEEIRRELSAGDLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JWN4</accession>
    <name>A0A2M9JWN4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Alpha-L-fucosidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CG723_10185</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CB01635</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Alpha-L-fucosidase is responsible for hydrolyzing the alpha-1,6-linked fucose joined to the reducing-end N-acetylglucosamine of the carbohydrate moieties of glycoproteins.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN11293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN11293">
        <property type="protein sequence ID" value="PJN11293"/>
        <property type="gene ID" value="CG723_10185"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004560">
        <property type="term" value="F:alpha-L-fucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006004">
        <property type="term" value="P:fucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016286">
        <property type="entry name" value="FUC_metazoa-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000933">
        <property type="entry name" value="Glyco_hydro_29"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10030">
        <property type="entry name" value="PTHR10030"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01120">
        <property type="entry name" value="Alpha_L_fucos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00741">
        <property type="entry name" value="GLHYDRLASE29"/>
    </dbReference>
    <dbReference type="SMART" id="SM00812">
        <property type="entry name" value="Alpha_L_fucos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014915962" evidence="5">
        <location>
            <begin position="33"/>
            <end position="787"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PJN11293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="787" mass="85260" checksum="1BAD50506472659D" modified="2018-04-25" version="1">MSSYPRRQVLGTAAAVTAAAAVPLAAAGPAAASDATATARTASADAVWGPVPDPVPVPLDALFDNDGVDTADARGGDFDGSGYTFPGEELPAGPVQVDGIAYVFPSSAAGAKNNVVAMGQRVELPKGRYLSALFLTAGSYGNASGSAVVHYADGSTASAGLGGADWYAAGGPLSAAYRYKPDGTKDTGRVGIGTSEIPLDAQREAVAITLPKLNPAEANKTALHVFALSLQPAAQGRALALRDAHSTFSLLESTGAQSVEATVVNAGTVGIVTADALTVSVDVPGARTVEPARVTRLAPGEQARVRVGIRNRAGTAPGTVQDGKVVATGRGHQAAASTRKLTLGVPDYQPTDASLSGHQAPYWFHSAKFGIFIHWGVYSVPAWAPVGKQYAEWYWDQMQDPNNPTYAHHKATYGEDFAYDDFIPMFTAKKWDPRAWVELFRDAGAQYHVLTSKHHEGFALWDTKLSDRNSVKMGPKRDIIKELFDASRRYTPELHRGLYFSMPEWFNPDNPWMGHAPRNPYTLEPVPYTGYTSGKDYVKGFQAPQMLELIHDYDPQLLWCDIGGVNDSHDVLAEFFNHGKNRPKPYEVAVNNRSGIGFHDFTTPEYTTYDNTVVAKWESSRGLDPYSYGYNAETPDDRYMTTEEVVHSLVDIVSKNGNFLLDIGPRADGTIPEIMQTRLRETGRWLKTNGEAVYDTTYWSRMAQLGEDLRFTVRPNKAFYIHSLAEPGATLTVEAAVPVRAGDKVMMLGYDRPLNWRTTGGSFVVDVPAAARAAGEHVWVFKVEWKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JYA6</accession>
    <name>A0A2M9JYA6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CG723_13525</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN11852.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN11852">
        <property type="protein sequence ID" value="PJN11852"/>
        <property type="gene ID" value="CG723_13525"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021530">
        <property type="entry name" value="DUF2877"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11392">
        <property type="entry name" value="DUF2877"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PJN11852.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="312" mass="32357" checksum="48BB6371BFED0667" modified="2018-04-25" version="1">MTSLRTATELRAISGDAALIAHLRALRGQGVVEGVFHRTVNVLTPGDRLIALAARGGGDAPSTLVTDADSWSGRGIVASRTVEFAPGVITIRAARGRLRVRTEGADEWHPILPSLAALGPGELATAASALDRLTRAHGSRGGMLGPTPAASPMAVAVTRALADGQDTLVRAIRSADDAGMRRGALSLLGLGPGLTPAGDDFLTALALLSSLHGSGLGHFGRALQDVLLEHPGRTTRLSVTTLDEALAGRARASLLDVLHALARPDRWGEVHVTQSIRTPVRHVLAIGHTSGTDILSGLVTGLRLEKELRGSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JYN7</accession>
    <name>A0A2M9JYN7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CG723_14360</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN11990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN11990">
        <property type="protein sequence ID" value="PJN11990"/>
        <property type="gene ID" value="CG723_14360"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045991">
        <property type="entry name" value="DUF5947"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19372">
        <property type="entry name" value="DUF5947"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PJN11990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="217" mass="24079" checksum="8D1A20897E91DCE9" modified="2018-04-25" version="1">MSTAHKRTRPPASGLRRFAAPRTSRPEVCELCGAPIDDGNHRHMVDTENRALACACTPCAMLFEQSGAGGGRFRTVPDRYLADPDHQLDPGAWELLQIPVSVAFFFRNASLDRLVALYPSPAGATESELDPSTWQTALGKSRLAELLEPDVEALLLRRVEERTECYLVPVDICYELVGRMRMLWQGFDGGAEARADLTAFFDHIAQRAGTPEEAHRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JYR0</accession>
    <name>A0A2M9JYR0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">TetR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_14475</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN12010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN12010">
        <property type="protein sequence ID" value="PJN12010"/>
        <property type="gene ID" value="CG723_14475"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="8"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="31"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN12010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="191" mass="20661" checksum="AAD5B0B01BE30991" modified="2018-04-25" version="1">MREAQPMTPAGRLIVTAAEELFYNRGITTVGVDLIAEHSGVTKRTLYNQFGSKDRLVATYLSERDQRWRSLVRATVDACDGPVEAVTAPFDALRTWSEANTRGCAFINALAELPDPTHPAHRIAANQKLWLLNLFTELATAAGCTGPAALATQLLVLHEGALATQPLPLDTLSESTALARSLVRADALPRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JYS3</accession>
    <name>A0A2M9JYS3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CG723_14550</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CB01635</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN12024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN12024">
        <property type="protein sequence ID" value="PJN12024"/>
        <property type="gene ID" value="CG723_14550"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="48"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="107"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="139"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="191"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="237"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="294"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="103"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PJN12024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="326" mass="35393" checksum="975D48FA3956FAE3" modified="2018-04-25" version="1">MTDAMSTVTTTESDTTVQVRRRIPTRTPHQAAGRARGAGRMGGPLTGLPWALPALLLVGVLLVYPFFRSVYGSLFEDNGFTSHYTGLDNYVRLAEDPIFGRSLLNTVMWVAGTLLLPVAAGLAIAVATHRMRFGRIAQLVVVLPCAISGAATAVLWKFILTSEGSLNQVLQGLGLGSLVRPWLLEWPQNTLAMIVAGTWQATGLNVVLFAIGLSAIPRETVEAAELDGATGWRMFRYITLPQLRSVSVVVIGMAIVNSLKAFDMIWVLTQGGPARSSETLALTMYRESFRLFHVGYGSAVALVLSVIVVASSWMYLRRQMPETSPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-06-02" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JYV2</accession>
    <name>A0A2M9JYV2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_14685</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN12046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN12046">
        <property type="protein sequence ID" value="PJN12046"/>
        <property type="gene ID" value="CG723_14685"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="23"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="116"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="174"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="216"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="228"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN12046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="242" mass="24967" checksum="4838B7AF4C6CCEA2" modified="2018-04-25" version="1">MATRRDPGHRDGRVRDTPYGERFTLFAEVIWIGVLVTLASLPLVTWPAAMAAGCAAVRRCVPDGPSVGTARRFAADWRRALRGGTLRGTAGLASLAFLAADLRIAAVAGDLPGHGLLVVVCAAAGVAVVVVQLRAAAAWSEPGDAGPATLANGFAGWRRVALARSRDDLVGSVILAAAVCATAVCAWQLLLLLPLVSGVLALAAVAVERRGREEKAARTECRRHGGTVLRTGQSSSSDGSSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JYW7</accession>
    <name>A0A2M9JYW7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_14805</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN12064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN12064">
        <property type="protein sequence ID" value="PJN12064"/>
        <property type="gene ID" value="CG723_14805"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="87"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN12064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="106" mass="11205" checksum="B7D8F75F3EAE469D" modified="2018-04-25" version="1">MSVEGTWDLSVSTPIGKIKAVVELLRQDGVLSGVAHGTGEKVPLSDIALDGDRLTWKQTVTKPLRLNLAFAVTISGDTLTGTSKAGRLPASKVTGRRRAVRAATEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-09-29" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JYZ7</accession>
    <name>A0A2M9JYZ7_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5">Gas vesicle structural protein</fullName>
            <shortName evidence="4">GVP</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">gvpA</name>
        <name evidence="7" type="ORF">CG723_08465</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CB01635</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Gas vesicles are small, hollow, gas filled protein structures that are found in several microbial planktonic microorganisms. They allow the positioning of the organism at the favorable depth for growth. GvpA type proteins form the essential core of the structure.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Vacuole</location>
            <location evidence="4">Gas vesicle membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 4 5">Belongs to the gas vesicle protein type A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN12091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN12091">
        <property type="protein sequence ID" value="PJN12091"/>
        <property type="gene ID" value="CG723_08465"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033172">
        <property type="term" value="C:gas vesicle shell"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005773">
        <property type="term" value="C:vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012506">
        <property type="term" value="C:vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00576">
        <property type="entry name" value="Gas_vesicle_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000638">
        <property type="entry name" value="Gas-vesicle_GvpA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018493">
        <property type="entry name" value="Gas-vesicle_GvpA_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00741">
        <property type="entry name" value="Gas_vesicle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00234">
        <property type="entry name" value="GAS_VESICLE_A_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00669">
        <property type="entry name" value="GAS_VESICLE_A_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4 5" id="KW-0304">Gas vesicle</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4 5" id="KW-0926">Vacuole</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="88"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="121"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PJN12091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="169" mass="18473" checksum="B9AE7D4650B742BB" modified="2018-04-25" version="1">MVPQGGNSVSRGGTGSLYDVLELILDRGLVIDIFVRVSLVGIEILKIDARIVVASVDTYLRFAEACNRLDLETGRKAPAQLTDIVGDTVESGAKGKSKGALTGAVDAVTDTIKGVTGRDEEDSEESEPEESEESESEEEDTREREPVERRRRSPRRTAHRSRGSSREKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JZ24</accession>
    <name>A0A2M9JZ24_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DNA-binding response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CG723_09830</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN12124.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN12124">
        <property type="protein sequence ID" value="PJN12124"/>
        <property type="gene ID" value="CG723_09830"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00622">
        <property type="entry name" value="HTH_LUXR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="1"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="domain" description="HTH luxR-type" evidence="3">
        <location>
            <begin position="142"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PJN12124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="212" mass="23050" checksum="9F2F7907B1EC0858" modified="2018-04-25" version="1">MIVAEDSALLRQGIVRLLSDEGFEVSAECSDTGPLLALVAEHRPDAVLLDIRMPPTHTDEGLIAAAAIRAAHPGTGVLLLSQYVETTDTVRALAEQPEGFGYLLKERVADIDELGGALKRVASGETVLDPLVVAKLMNTPRPRSPLDDLTGRERDVLALMAEGHSNEAIAQRLVIGGKTVETHVRNIFGKLRLEQDLLEHRRVRAVLTYLRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JZ87</accession>
    <name>A0A2M9JZ87_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CG723_12475</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CB01635</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN12184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN12184">
        <property type="protein sequence ID" value="PJN12184"/>
        <property type="gene ID" value="CG723_12475"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="48"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="101"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="205"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="44"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PJN12184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="240" mass="25607" checksum="4014EBDF66375764" modified="2018-04-25" version="1">MLAAAGPQPVIPDFGTVSSCVRDNGLFCVDWFTANFSSMFGPALVQHVRLTVIAVGVGFLIAFPLALLAHFRRRLVKPLGGLTSFLYTIPPMALFTLLVPVFGLSVLTAEIALVSYTLMVLFKSSLTGLGEVPEEVRRAGEGMGLTRREILWRIELPLALPAVINGLRVATVTTISVVEVAAFIIDQGLGSPIIQGLQSPFNTQFIGAGLLAVALALAADGLIVLVGRLLTPWARTRRTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JZL6</accession>
    <name>A0A2M9JZL6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Calcium-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_04375</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000002">
        <property type="protein sequence ID" value="PJN12298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN12298">
        <property type="protein sequence ID" value="PJN12298"/>
        <property type="gene ID" value="CG723_04375"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013658">
        <property type="entry name" value="SGL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005511">
        <property type="entry name" value="SMP-30"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08450">
        <property type="entry name" value="SGL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01790">
        <property type="entry name" value="SMP30FAMILY"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SGL" evidence="1">
        <location>
            <begin position="13"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN12298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="282" mass="29808" checksum="6DDB5FC6D859635E" modified="2018-04-25" version="1">MRPEVAVRAEATLGEGPTWDAEAGRLIWVDILGSRVHTYEPATGRRTVMATEQHVGAAKPRAGGAGLVVNLRDGIGLYGPGGKGFRWLHRDPVPGRRGNDAAVAPDGSLWAGSMAYDETPGGGNLLRIAPDGTTTEILGDVTVSNGTGWSPDGTLMYYVDTPTRRIDVFDVDGQQVVRRREFAVVEEGAGHPDGLTVDADGCVWVALWDGSALRRYTPSGALDRVVELPVKRPTACAFGGADLTDLYVTSARVGLDAPSPYAGSLLVLRDMGRGLAQPAFEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JZQ4</accession>
    <name>A0A2M9JZQ4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CG723_04720</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000002">
        <property type="protein sequence ID" value="PJN12359.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN12359">
        <property type="protein sequence ID" value="PJN12359"/>
        <property type="gene ID" value="CG723_04720"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PJN12359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="54" mass="5929" checksum="BDFA68BD6535D8A5" modified="2018-04-25" version="1">MATTSEPATVRPAAEVNEQIRALWLRAGGRLSAEERVEYEALVVEWAAAMREAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K035</accession>
    <name>A0A2M9K035_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Protein tyrosine phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CG723_05565</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000002">
        <property type="protein sequence ID" value="PJN12502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN12502">
        <property type="protein sequence ID" value="PJN12502"/>
        <property type="gene ID" value="CG723_05565"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004721">
        <property type="term" value="F:phosphoprotein phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016311">
        <property type="term" value="P:dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026893">
        <property type="entry name" value="Tyr/Ser_Pase_IphP-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13350">
        <property type="entry name" value="Y_phosphatase3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="SSF52799"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PJN12502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="266" mass="27920" checksum="474734C9151E706F" modified="2018-04-25" version="1">MPAIPATTVANLRDLGGIPLPGGRTVHPGLALRSGQLDRLDPATDPAFAALGIHTIVDFRTNGERASYPDHVPDGVHVLVADALADKIAQTGAAPAAAQLKHVLSDPALADEKLGGGRAESLFADTYRALVSTKSARAAYRTLLTELADPDAGPLLFHCTAGKDRTGWAATVVLTLLGADQAALETEYLSVNPAVREAFAPLVEGFTAQGGDPEIALALIGVRASYLHAAQDEVTVQYGDFETYVREGLEVPDEAVERIRKRLTAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K073</accession>
    <name>A0A2M9K073_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PPM-type phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_05715</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000002">
        <property type="protein sequence ID" value="PJN12529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN12529">
        <property type="protein sequence ID" value="PJN12529"/>
        <property type="gene ID" value="CG723_05715"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07228">
        <property type="entry name" value="SpoIIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00331">
        <property type="entry name" value="PP2C_SIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="SSF81606"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="31"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="69"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="101"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="domain" description="PPM-type phosphatase" evidence="2">
        <location>
            <begin position="146"/>
            <end position="367"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN12529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="378" mass="40347" checksum="FEF3084D969306F9" modified="2018-04-25" version="1">MGRSPPMTGALSRRRDGEERAWLRGAPPPRWVRWLPVGLLAALCLAQLVTEEKLDLGFLLGAVPPLAALTYGPAATALLGGTVIVLLNVPFMNLGHPGNSDVLTVSFVALLSVLIGWVRSRRDAQLVTVRTVAEAAQFAVLPPLRDRVGTVRCAGLYRAAERGTLVGGDLFDVRRGPAGVRAVIGDVQGHGLSAVATVAGLLGAFREAVLDQSDLKGVAARLDRRLVVDSAEDEHAELFATALLLEFPDDSPVVRAVSCGHPRPLLLRGQEVIELPVPSGAPLGLGIAGLAPLEQLTVRLRPGDRLLGLTDGLIEARDPSGAFYPLRERLGRFSEDDPAELTDALWRDVVRFAGTVRDDLTLLVFAPEIAPEDDPEDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K0E6</accession>
    <name>A0A2M9K0E6_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF4396 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CG723_06080</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000002">
        <property type="protein sequence ID" value="PJN12598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN12598">
        <property type="protein sequence ID" value="PJN12598"/>
        <property type="gene ID" value="CG723_06080"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025509">
        <property type="entry name" value="DUF4396"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14342">
        <property type="entry name" value="DUF4396"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="37"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="67"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="99"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="134"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4396" evidence="3">
        <location>
            <begin position="30"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF14342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PJN12598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="172" mass="18323" checksum="47AA4F7B60B4E2FA" modified="2018-04-25" version="1">MKHETRAGHEHHADHEQHAHAGHGGLGKVSWSMAAQATLHCLTGCAIGEVLGMVIGTAFGWGNAPTMILAIALAFFFGYALTLRGILKAGVDFRTAFRVALAADTLSIAVMELIDNGVIVLWPNAMDAHLTDGLFWGALAASLAIAFVVTTPVNKWMIGRGKGHAVVHQYHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K0I4</accession>
    <name>A0A2M9K0I4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_06345</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000002">
        <property type="protein sequence ID" value="PJN12642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN12642">
        <property type="protein sequence ID" value="PJN12642"/>
        <property type="gene ID" value="CG723_06345"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018721">
        <property type="entry name" value="DUF2252"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39441">
        <property type="entry name" value="PTHR39441"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10009">
        <property type="entry name" value="DUF2252"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN12642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="475" mass="52178" checksum="957288757DC72685" modified="2018-04-25" version="1">MRWTEQDSCPPRHDPRSPSAVTPDGTARTRRHPAMSVPQPTAEQRGEQILTVFDTAFGELLAADPAAFRVKFRKMASSAFAFYRGTACLFYADLERERHGGPYLDDRTGRVWIHGDLHAENFGTYMDSTGRLIFNVNDFDEAYVGPFTWDLKRFAASVALIGYSKALGDEQITELVQVYAGAYRERIHALATGAKSDEVPPFTLDTAEGPLLDALRDARSLTRFGLLDSMTEIRDFERRFAPGGGSIELDAATRYKVLAAFDGYLETLPESSLTRPDSYRVKDVVGRRGIGIGSAGLPSYNILLEGNSDALENDVVIYLKQAQTPAVSRHITDAAIRDYFEHEGHRTVISQRALQAHADPWLGWTELDGSGQLVAEVSPYAVDLDWSDIDDLDEIAAVVADLGRATATMHAAADDLSGQSLVPFSTERAIDAAIAADEDGFAGLLVDFAHDYGARARADHQIFVDLFRNGRIPGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K0N0</accession>
    <name>A0A2M9K0N0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Short chain dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CG723_06630</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000002">
        <property type="protein sequence ID" value="PJN12693.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN12693">
        <property type="protein sequence ID" value="PJN12693"/>
        <property type="gene ID" value="CG723_06630"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PJN12693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="261" mass="27339" checksum="307B6F482472033A" modified="2018-04-25" version="1">MSAKPEYVPGHGLLKGRTAVITAAAGAGIGGATARKFLEEGARVVISDAHARRLKESEQALADEFGAANVASLPCDVTDEEQVGALFSLAAETHGGLDIVVNNAGLGGTSDLVDMTDDQWTRVLDVTLNGTFRCTRAALRSFRDTGRHGVVVNNASVVGWRAQAGQAHYAAAKAGVMALTRCAAIEAAEYGVRVNAVSPSLAMHPHLVKVTSAELLAELTEKEAFGRYAEPWEVANVIVFLASGYSSYMTGEIVSVSSQHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K0S3</accession>
    <name>A0A2M9K0S3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Flavin-dependent monooxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_06730</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000002">
        <property type="protein sequence ID" value="PJN12706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN12706">
        <property type="protein sequence ID" value="PJN12706"/>
        <property type="gene ID" value="CG723_06730"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016627">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013107">
        <property type="entry name" value="Acyl-CoA_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08028">
        <property type="entry name" value="Acyl-CoA_dh_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="SSF47203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="SSF56645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA_dh_N" evidence="1">
        <location>
            <begin position="10"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_2" evidence="2">
        <location>
            <begin position="240"/>
            <end position="372"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN12706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="394" mass="42382" checksum="5CAD94FC605B40E1" modified="2018-04-25" version="1">MSESPATAAAVLEAVRALAPALRERAAEAEALRKVPDTSIKDLEQTGFFRLLQPRAYGGFAADPAVFYAAVREIARACGSTGWVASVVGVHPWHVALYDPRAQEEVWGADPSTRICSSYAPTGKVTPVGGGFRISGSWSFSSGCDHADWALLGGLVLDADGRPVDMRTFLVPRAEYRIDDVWDTVGLRGTGSNNVVCEDVFVPEHRALSFGPVTALNVPGHEVNPEPLYRLPYAAVFTTTISTPIVGIAEGALDAYVEATRKRFRVSYGQQVAEDPFAQVRIARAASDIDAAGLQLQRNINELYACAERGEELPMPLRARARRDQVLATERAVAAVDLLMENAGGGAMRTGPHPVQRAWRDVHTGRGHAANDPERALVLSGQSALGLDIQDTML</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K0X3</accession>
    <name>A0A2M9K0X3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Mycothiol maleylpyruvate isomerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_07160</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000002">
        <property type="protein sequence ID" value="PJN12782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN12782">
        <property type="protein sequence ID" value="PJN12782"/>
        <property type="gene ID" value="CG723_07160"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017517">
        <property type="entry name" value="CHP03083_actinobac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034660">
        <property type="entry name" value="DinB/YfiT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024344">
        <property type="entry name" value="MDMPI_metal-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036527">
        <property type="entry name" value="SCP2_sterol-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11716">
        <property type="entry name" value="MDMPI_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109854">
        <property type="entry name" value="SSF109854"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55718">
        <property type="entry name" value="SSF55718"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03083">
        <property type="entry name" value="TIGR03083"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="2" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MDMPI_N" evidence="1">
        <location>
            <begin position="11"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF11716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN12782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="229" mass="24482" checksum="048F4CC412093995" modified="2018-04-25" version="1">MSDHVRDLASVREATDRLLTAVGTLDNAAVAESSRLPGWSRGHVLAHLARNADALANVLAGRPMYPSAEARDADIARDAPRDLREQLEDLRTSATGFEARAEVPADWARTVELRNGVKDSASRIPFRRWGEVDLHHVDLGIGYELEDLPAEFVEREIDFLAERFAGHQDMPSTGLKSDGGRVWTTGGGAGTGPVGVAGPAPELLGWLSGRRDGSGLTVEGGPLPVVPPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K172</accession>
    <name>A0A2M9K172_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">SUF system NifU family Fe-S cluster assembly protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_07350</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000002">
        <property type="protein sequence ID" value="PJN12820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN12820">
        <property type="protein sequence ID" value="PJN12820"/>
        <property type="gene ID" value="CG723_07350"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06664">
        <property type="entry name" value="IscU_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002871">
        <property type="entry name" value="NIF_FeS_clus_asmbl_NifU_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10093">
        <property type="entry name" value="PTHR10093"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01592">
        <property type="entry name" value="NifU_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NifU_N" evidence="1">
        <location>
            <begin position="6"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN12820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="153" mass="16827" checksum="6FDA889BBC5C0ED8" modified="2018-04-25" version="1">MKLDSMYQDVILDHYKHPHGRGLRDGDAEVHHVNPTCGDEITLRVKYDGSTISDVSYEGQGCSISQASASVLNELLVGKDLAEAQKIQETFLELMQSRGRIEPDDAMEEVLEDAVAFAGVSKYPARVKCALLSWMAWKDATAQALDGAERKTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K182</accession>
    <name>A0A2M9K182_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Transport permease protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CG723_07410</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CB01635</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the ABC-2 integral membrane protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000002">
        <property type="protein sequence ID" value="PJN12830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN12830">
        <property type="protein sequence ID" value="PJN12830"/>
        <property type="gene ID" value="CG723_07410"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046677">
        <property type="term" value="P:response to antibiotic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC_2_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000412">
        <property type="entry name" value="ABC_2_transport"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01061">
        <property type="entry name" value="ABC2_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006648">
        <property type="entry name" value="DrrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00164">
        <property type="entry name" value="ABC2TRNSPORT"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51012">
        <property type="entry name" value="ABC_TM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0046">Antibiotic resistance</keyword>
    <keyword evidence="8" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="25"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="66"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="112"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="149"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="184"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="236"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="domain" description="ABC2_membrane" evidence="9">
        <location>
            <begin position="13"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PJN12830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="264" mass="27882" checksum="701D0AF6371D266D" modified="2018-04-25" version="1">MSSLSLAVRDSSTMLRRNLLHARRYPSMTLNLLLTPVVLLLLFVYIFGDVMSAGISGGGADRSAYIAYLVPGILMLTIGGTTIGSAVSVSMDMTEGIIARFRTMSIHRGSVLIGHVVGSVLQCVMSVVLVGAVAVAIGFRATDATVLEWILAVGLLALVSLALTWIAVGMGLSSPNAEAASNNAMPLMVLPLLSSAFVPVDAMPGWFQPIAEYQPFTPAIETVRGLLLGTEIGNNGWLAVAWCVALAVLGYVWSRSLFNSIGKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K1I0</accession>
    <name>A0A2M9K1I0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">N-acetylmuramoyl-L-alanine amidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CG723_05700</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CB01635</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the N-acetylmuramoyl-L-alanine amidase 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000002">
        <property type="protein sequence ID" value="PJN12993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN12993">
        <property type="protein sequence ID" value="PJN12993"/>
        <property type="gene ID" value="CG723_05700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008745">
        <property type="term" value="F:N-acetylmuramoyl-L-alanine amidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009253">
        <property type="term" value="P:peptidoglycan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06583">
        <property type="entry name" value="PGRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.80.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036505">
        <property type="entry name" value="Amidase/PGRP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002502">
        <property type="entry name" value="Amidase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015510">
        <property type="entry name" value="PGRP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006619">
        <property type="entry name" value="PGRP_domain_met/bac"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11022">
        <property type="entry name" value="PTHR11022"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01510">
        <property type="entry name" value="Amidase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00701">
        <property type="entry name" value="PGRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55846">
        <property type="entry name" value="SSF55846"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PGRP" evidence="3">
        <location>
            <begin position="66"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PJN12993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="263" mass="28025" checksum="4E54142D1ECF3812" modified="2018-04-25" version="1">MCAVTVGPGDGGSAARSGRAAGPTATDRAAPALPPAAVPVRRPPVLSSAALRVRRPVNRRHTAALPRIVPRADWLADAAYRRPPARYADRVTAVFIHHTDSPNVYDCADTPRIIRYLYAGQAGGRNWDDIGYNFLVDRCGTIYEGRAGGVDKAVVGAHAQGFNQGTAGIAAIGTFTAGTPVPPSMTKSIAALSAWKLGLANIDPRSRVRLTSTNSLSRFRKGRTAEFNAIAAHRDEYETYCPGQALMAELPEIRQRAAALQGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K1I3</accession>
    <name>A0A2M9K1I3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">LysR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_05065</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LysR transcriptional regulatory family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000002">
        <property type="protein sequence ID" value="PJN12978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN12978">
        <property type="protein sequence ID" value="PJN12978"/>
        <property type="gene ID" value="CG723_05065"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005119">
        <property type="entry name" value="LysR_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000847">
        <property type="entry name" value="Tscrpt_reg_HTH_LysR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00126">
        <property type="entry name" value="HTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03466">
        <property type="entry name" value="LysR_substrate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00039">
        <property type="entry name" value="HTHLYSR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50931">
        <property type="entry name" value="HTH_LYSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH lysR-type" evidence="2">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN12978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="304" mass="32363" checksum="A127B3C3CC9CA08F" modified="2018-04-25" version="1">MELRHLSGFVAVAEELHFGRAAERLHIAQSPLSQQIKLLERDLGVKLFDRTTRTVRLTAAGHALLGPARHLLAEASAVRRTVQAAHLGEVGRVTVGFAGASSYSALPLLTRAVTSELPGIELVLEGQTYTGEALGRIADGSLDVGFVALPVRRGITARVVRMERLVLALPDSHPLARQDEVHFAELAHEPFVTFPVARGSAVREAMVQACHEAGFAPRIAQEAPDSYNMLALVGAGVGLAVVVASARAIHLEHVVFRPLAGDDVPVLPIALGWRTGNRSAPLQAVLRVAEEVLPTPPDAPDARG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K1S3</accession>
    <name>A0A2M9K1S3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_00220</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000001">
        <property type="protein sequence ID" value="PJN13068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN13068">
        <property type="protein sequence ID" value="PJN13068"/>
        <property type="gene ID" value="CG723_00220"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014805981" evidence="1">
        <location>
            <begin position="22"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN13068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="241" mass="25349" checksum="83654D6427728AD9" modified="2018-04-25" version="1">MLVAAAVCPCPPLLVPEVAVGAAPELEAARAACDEAVRAVLAARPDLIVVVGEGPATRTHKHGAMGGFQPFGVDREVRLGAAPDSEAPAHRLPLSLTVGAWLLDRAGWTGPVEGYEVESDRSWPANGEDGVHLAARADRVGFLVMGDGTACRSVKAPGYLDDRAEGVDASIAQALGNGDHDGFFATLDADLARELKISGRSPWQILTAASVEDEDQDECQNWSVLYEDAPYGVGYFVASWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K1S9</accession>
    <name>A0A2M9K1S9_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 10">Vitamin B12-dependent ribonucleotide reductase</fullName>
            <ecNumber evidence="4 10">1.17.4.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CG723_00310</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">CB01635</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9 10">Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and/or for immediate growth after restoration of oxygen.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>[thioredoxin]-disulfide + a 2'-deoxyribonucleoside 5'-diphosphate + H2O = [thioredoxin]-dithiol + a ribonucleoside 5'-diphosphate</text>
            <dbReference type="Rhea" id="RHEA:23252"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="ChEBI" id="CHEBI:57930"/>
            <dbReference type="ChEBI" id="CHEBI:73316"/>
            <dbReference type="EC" id="1.17.4.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 10">
            <name>adenosylcob(III)alamin</name>
            <dbReference type="ChEBI" id="CHEBI:18408"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the ribonucleoside diphosphate reductase class-2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.17.4.1" evidence="4 10"/>
    <dbReference type="EMBL" id="NNBL01000001">
        <property type="protein sequence ID" value="PJN13084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN13084">
        <property type="protein sequence ID" value="PJN13084"/>
        <property type="gene ID" value="CG723_00310"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031419">
        <property type="term" value="F:cobalamin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050897">
        <property type="term" value="F:cobalt ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004748">
        <property type="term" value="F:ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071897">
        <property type="term" value="P:DNA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02888">
        <property type="entry name" value="RNR_II_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013678">
        <property type="entry name" value="RNR_2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000788">
        <property type="entry name" value="RNR_lg_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013344">
        <property type="entry name" value="RNR_NrdJ/NrdZ"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08471">
        <property type="entry name" value="Ribonuc_red_2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02867">
        <property type="entry name" value="Ribonuc_red_lgC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01183">
        <property type="entry name" value="RIBORDTASEM1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02504">
        <property type="entry name" value="NrdJ_Z"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0846">Cobalamin</keyword>
    <keyword evidence="8 10" id="KW-0170">Cobalt</keyword>
    <keyword evidence="7 10" id="KW-0237">DNA synthesis</keyword>
    <keyword evidence="10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ribonuc_red_2_N" evidence="13">
        <location>
            <begin position="54"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="domain" description="RIBORED_LARGE" evidence="12">
        <location>
            <begin position="158"/>
            <end position="697"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00014409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022628"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU364064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF02867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF08471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="PJN13084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="968" mass="105459" checksum="54D755119A587A8F" modified="2018-04-25" version="1">MTETTSGPARGSRAKGAKANKGLRIERIHTTPGVHPYDEVEWERRDVVMTNWRDGSINFEQRGVEFPGFWSVNAVNIVTSKYFRGAVGTPQREVSLRQLIDRIVKTYRKAGEDHNYFSSPADAEIFEHELAYALLHQIFSFNSPVWFNVGTPQPQQVSACFILAVDDSMESILDWYKEEGMIFKGGSGAGLNLSRIRSSKELLSSGGNASGPVSFMRGADASAGTIKSGGATRRAAKMVILDVDHPDIENFIETKVKEEEKIRALRDAGFDMDLGGDDITSVQYQNANNSVRVNDEFMKAVETGGKFGLRARMTGDVIEEVDAKSLFRKMAEAAWACADPGIQYDDTINQWHTCPESGRINGSNPCSEYMHLDNTSCNLASLNLMKFLKDDSKGHQSFDVERFSKVVELVITAMDISICFADFPTQKIGENTRAFRQLGIGYANLGALLMATGHAYDSEGGRALAGSITSLMTGTSYKRSAELAAVVGPYDGYARNAAPHQRVMKQHADANTKAVRIDDLDTPIWAAATEAWQDVVRLGEKNGFRNSQASVIAPTGTIGLAMSCDTTGLEPDLALVKFKKLVGGGSMQIVNGTVPQALRRLGYQEEQIEAIVAHIADNGNVIDAPGLKTEHYEVFDCAMGERSISAMGHVRMMAAIQPWISGALSKTVNLPETASVEDVEEVYFEAWKMGVKALAIYRDNCKVGQPLSAKTKTKEKEAVTAKAEETIRTAVEKVVEYRPVRKRLPKGRPGITTSFTVGGAEGYMTANSYPDDGLGEVFLKMSKQGSTLAGMMDAFSIAVSVGLQYGVPLETYVSKFTNMRFEPAGMTDDPDVRMAQSIVDYIFRRLALDFLPFETRSALGIHSAEERQRHLETGSYEQSIDDVEVDVEGLAQSAPRQTESLKAVVEAPKAEAVAAAPAPQQAHTSAELVEMQLGIQADAPLCFSCGTKMQRAGSCYICEGCGSTSGCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-09-29" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K299</accession>
    <name>A0A2M9K299_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CG723_01305</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000001">
        <property type="protein sequence ID" value="PJN13252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN13252">
        <property type="protein sequence ID" value="PJN13252"/>
        <property type="gene ID" value="CG723_01305"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PJN13252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="258" mass="28044" checksum="0269CF708320F5D6" modified="2018-04-25" version="1">MEKFDTYHWQGRHLEDPELEEARIELVSPQSGDAARHAFTRLLCSDSIQAMGIALDHYHYALSGERHGMASLFAPYASDVLECARKILRRPPVSATYEASAIDKAACASALLVLVNEATPEDSDLIARSIEEAPGPDALSAALGAAGTILDSVREPSPRLVAVMERLIFDESVDFDERLEALQALAQGSSPVVMAVLVRASALEDLELQVTAVQGLGFHDMGTYRGLVEERSASWPEGAPYPAADVRRLLREDDRGSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-05-25" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K2S2</accession>
    <name>A0A2M9K2S2_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 7">Malate synthase</fullName>
            <ecNumber evidence="2 7">2.3.3.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CG723_02275</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CB01635</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>acetyl-CoA + glyoxylate + H2O = (S)-malate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18181"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15589"/>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="EC" id="2.3.3.9"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="7">Carbohydrate metabolism; glyoxylate cycle; (S)-malate from isocitrate: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the malate synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.3.9" evidence="2 7"/>
    <dbReference type="EMBL" id="NNBL01000001">
        <property type="protein sequence ID" value="PJN13422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN13422">
        <property type="protein sequence ID" value="PJN13422"/>
        <property type="gene ID" value="CG723_02275"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00703">
        <property type="reaction ID" value="UER00720"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004474">
        <property type="term" value="F:malate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006097">
        <property type="term" value="P:glyoxylate cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00727">
        <property type="entry name" value="malate_synt_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1220.12">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044856">
        <property type="entry name" value="Malate_synth_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011076">
        <property type="entry name" value="Malate_synth_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006252">
        <property type="entry name" value="Malate_synthA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001465">
        <property type="entry name" value="Malate_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019830">
        <property type="entry name" value="Malate_synthase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046363">
        <property type="entry name" value="MS_N_TIM-barrel_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42902">
        <property type="entry name" value="PTHR42902"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01274">
        <property type="entry name" value="Malate_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001363">
        <property type="entry name" value="Malate_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51645">
        <property type="entry name" value="SSF51645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01344">
        <property type="entry name" value="malate_syn_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00510">
        <property type="entry name" value="MALATE_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0329">Glyoxylate bypass</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 7" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="active site" description="Proton acceptor" evidence="6">
        <location>
            <position position="169"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="6">
        <location>
            <position position="454"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR001363-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PJN13422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="545" mass="60485" checksum="E6406F61B99B968D" modified="2018-04-25" version="1">MSAPAPSPLAIVDAEPLPRQEEVLTDAALAFVAELHRLFTPRRDELLTRRAERRAEIARTSTLDFLPETAHIREDTTWRVAPAPAALNDRRVEITGPTDRKMTINALNSGAKVWLADFEDASAPTWENVVLGQVNLMDAYTRNIDFTDERTGKSYALKGNDELATVVMRPRGWHLDERHLKDEAGRPVPGALVDFGLYFFHNAKRLIELGKGPYFYLPKTESHLEARLWNEIFVFAQDYVGIPQGTVRATVLIETITAAYEMDEILYELRDHAAGLNAGRWDYLFSIVKNFRDGGAKFVLPDRNLVTMTAPFMRAYTELLVRTCHKRGAHAIGGMAAFIPSRRDAEVNKVAFEKVKNDKDREAGDGFDGSWVAHPDLVPIAMASFDAVLGDKPNQKERLREDVSVAPGDLIAIDSLDARPTYDGLVNAVQVGIRYIEAWLRGLGAVAIFNLMEDAATAEISRSQIWQWINAGVVFEGGEHSGTTVTADLAREVAAQELANIKAEIGEEAFAAGKWQQAHDLLLQVSLDADYADFLTLPAYEQLAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K2T8</accession>
    <name>A0A2M9K2T8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">FAD-binding molybdopterin dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_02030</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000001">
        <property type="protein sequence ID" value="PJN13380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN13380">
        <property type="protein sequence ID" value="PJN13380"/>
        <property type="gene ID" value="CG723_02030"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002346">
        <property type="entry name" value="Mopterin_DH_FAD-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00941">
        <property type="entry name" value="FAD_binding_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="SSF56176"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="1">
        <location>
            <begin position="1"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN13380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="276" mass="30091" checksum="04478548BDCF7512" modified="2018-04-25" version="1">MDLNTVKEVRDGRLREPWQPGDAWLGGGTYLFSEPQPHLRRLVDLSRMGWESLTLGEDGALEIAATCTIAQLSRFGRQFAAEAAPLFEQCCRAFLASFKIWNMATVGGNLCNGLPAGPMISLTAALDGTCLLQSQAGVRRTVKVADFITGAGRKDLGEGELLRSLTLPARALGCRTAFRQASLYGLGRSGALVIGALDPVDGSMAVTISAATVRPFRLWFPLPPDKGELRRAIEAAVGEDDWFDDIHGLPEWRRHMGFRLAEEVRHELTRLSQDGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K2Z9</accession>
    <name>A0A2M9K2Z9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Exodeoxyribonuclease III</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">xth</name>
        <name evidence="3" type="ORF">CG723_02450</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DNA repair enzymes AP/ExoA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000001">
        <property type="protein sequence ID" value="PJN13450.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN13450">
        <property type="protein sequence ID" value="PJN13450"/>
        <property type="gene ID" value="CG723_02450"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008853">
        <property type="term" value="F:exodeoxyribonuclease III activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09086">
        <property type="entry name" value="ExoIII-like_AP-endo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004808">
        <property type="entry name" value="AP_endonuc_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037493">
        <property type="entry name" value="ExoIII-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43250">
        <property type="entry name" value="PTHR43250"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03372">
        <property type="entry name" value="Exo_endo_phos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="SSF56219"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00633">
        <property type="entry name" value="xth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51435">
        <property type="entry name" value="AP_NUCLEASE_F1_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Endo/exonuclease/phosphatase" evidence="2">
        <location>
            <begin position="4"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007092"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN13450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="259" mass="28319" checksum="2DDE22B1583E8DA9" modified="2018-04-25" version="1">MRIATWNVNSIAARLPRLLAWLESTGTDVLCVQETKCTAEQFPADELRELGYESAVNANGRWNGVALISRVGLEDVVTGLPGDPGYEGAHEPRAISATCGPARVWSVYVPNGREVDHPHYAYKLQWFEALKAAVAGDAGGSRPFAVMGDYNVAPTDDDVWDISLFDGATHVTPAERAALAALRETGLSDVVPRPLKYDHPFTYWDYRQLGFPKNRGMRIDLVYGNAAFAGAVKDSYVDREERKGKGASDHAPVVVDLEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K382</accession>
    <name>A0A2M9K382_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_03225</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000001">
        <property type="protein sequence ID" value="PJN13585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN13585">
        <property type="protein sequence ID" value="PJN13585"/>
        <property type="gene ID" value="CG723_03225"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002782">
        <property type="entry name" value="Mut7-C_RNAse_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027798">
        <property type="entry name" value="Ub_Mut7C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01927">
        <property type="entry name" value="Mut7-C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14451">
        <property type="entry name" value="Ub-Mut7C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ub-Mut7C" evidence="2">
        <location>
            <begin position="4"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="domain" description="Mut7-C" evidence="1">
        <location>
            <begin position="91"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN13585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="242" mass="26473" checksum="70D1224FA06A4BDA" modified="2018-04-25" version="1">MNGPEIVVSVVPELELFVPHARRGGAAVPLVTDGVSTLGHVIESLGVPLTEVGALVVDGREVAVGHIPVAGERVEVRAVVRPQSVEGAPLRFLLDVHLGTLARRLRLLGVDSAYESTDIGDPALAARSAAERRVMLSRDRGLLRRRELWAGAYVYSDRPDEQLRDVLGRFTPELRPWSRCTACNGLLKEARKEDVVDLLEGGTRGTYDVFAQCRTCGRVYWRGAHHDRLERIVGRAVAEFGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-09-29" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K3E7</accession>
    <name>A0A2M9K3E7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Acetyl-CoA acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CG723_03595</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CB01635</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the thiolase-like superfamily. Thiolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000001">
        <property type="protein sequence ID" value="PJN13642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN13642">
        <property type="protein sequence ID" value="PJN13642"/>
        <property type="gene ID" value="CG723_03595"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00751">
        <property type="entry name" value="thiolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002155">
        <property type="entry name" value="Thiolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020610">
        <property type="entry name" value="Thiolase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020617">
        <property type="entry name" value="Thiolase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020613">
        <property type="entry name" value="Thiolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020616">
        <property type="entry name" value="Thiolase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02803">
        <property type="entry name" value="Thiolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00108">
        <property type="entry name" value="Thiolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000429">
        <property type="entry name" value="Ac-CoA_Ac_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01930">
        <property type="entry name" value="AcCoA-C-Actrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00737">
        <property type="entry name" value="THIOLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00099">
        <property type="entry name" value="THIOLASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Thiolase_N" evidence="4">
        <location>
            <begin position="7"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="domain" description="Thiolase_C" evidence="5">
        <location>
            <begin position="282"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-thioester intermediate" evidence="2">
        <location>
            <position position="93"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="2">
        <location>
            <position position="360"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="2">
        <location>
            <position position="390"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000429-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PJN13642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="404" mass="42146" checksum="BEB9C152E72755F5" modified="2018-04-25" version="1">MSTEAYVYDAIRTPRGRGKANGALHGTKPIDLVVGLIHEVQRRFPDLDPAAIDDIVLGVVGPVGDQGSDIARIAAIAAGLPDTVAGVQENRFCASGLEAVNLAAMKVRSGWEDLVLAGGVESMSRVPMASDGGAWFADPMTNYETGFVPQGIGADLIATIEGFSRRDVDEYAALSQERAAAAVKDGRFARSVVPVTDRSGLTVLDHDEFLRPGTTADSLAKLKPSFADIGDLGGFDAVALQKYHWVEKIDHVHHAGNSSGIVDGASLVAIGTKEVGERHGLTPRARIVSAAVSGSEPTIMLTGPAPAARKALAKAGLTIDDIDLVEINEAFAAVVLRFVKDMGLSLDKVNVNGGAIALGHPLGATGAMILGTLIDELERQDKRYGLATLCVGGGMGIATIVERL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K3J9</accession>
    <name>A0A2M9K3J9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Sugar-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CG723_03980</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000001">
        <property type="protein sequence ID" value="PJN13706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN13706">
        <property type="protein sequence ID" value="PJN13706"/>
        <property type="gene ID" value="CG723_03980"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006584">
        <property type="entry name" value="Cellulose-bd_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005084">
        <property type="entry name" value="CMB_fam6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012938">
        <property type="entry name" value="Glc/Sorbosone_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022409">
        <property type="entry name" value="PKD/Chitinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000601">
        <property type="entry name" value="PKD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035986">
        <property type="entry name" value="PKD_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011041">
        <property type="entry name" value="Quinoprot_gluc/sorb_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029010">
        <property type="entry name" value="ThuA-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03422">
        <property type="entry name" value="CBM_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07995">
        <property type="entry name" value="GSDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06283">
        <property type="entry name" value="ThuA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00606">
        <property type="entry name" value="CBD_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00089">
        <property type="entry name" value="PKD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49299">
        <property type="entry name" value="SSF49299"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="SSF49785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50952">
        <property type="entry name" value="SSF50952"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51175">
        <property type="entry name" value="CBM6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50093">
        <property type="entry name" value="PKD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="1" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PKD" evidence="3">
        <location>
            <begin position="753"/>
            <end position="836"/>
        </location>
    </feature>
    <feature type="domain" description="CBM6" evidence="4">
        <location>
            <begin position="950"/>
            <end position="1083"/>
        </location>
    </feature>
    <feature type="domain" description="PKD" evidence="3">
        <location>
            <begin position="1121"/>
            <end position="1178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PJN13706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="1178" mass="125822" checksum="1643BBCA90D621A1" modified="2018-04-25" version="1">MSSTSSATPVPSGRHGPPAPAARIPRRRRRPCSPWTVLLALIALVVGLGLAAPPRAEAAASYRVLVFSKVTNFAHDSIPAGIDAIKKLGSENGFEVEATDDAAVFTDENLARFKAIVFNNTNSTPETGDLLDADQRAALQKYVRGGGGWVGLHAASASERDWGWYEGLVGAIFDQHPAVQTGRIKVLDHAHPSTKGLPELWERTEEWYNWRTNPTGKVHTLAQVKVRDGVTGLDEGVDHPWSWCQNYDGGRSWFTAGGHAKSAFEEAGFLQHILGGIQWAAGDKPGDCSATRTGSFQRTPLATADLADPFELAVAPDRRVFFIQRTGKLKIIDQETLKVTTALDLAYTPEMTSQSDGLLGLALDPKFGDNHWIYLLNSDKTEKRINLSRFTESGGKVDPASEKRLLTVPTWRGEGRANSHMAGSIAFDNKGDLYIATGDNTDPFASDGFNPIDEGEGRRAWDAQGTAGNTNDLRGKVLRITPKADGTYGVPEGNLFAPGTDKTRPEIYAMGMRNPFRITTDPVSGALLMGDYGPDARNAVADRGPEGTVEFNRITEAGNYGWPYCIGDNTPFNDYDFESKKSGAKFDCDHLVNDSPNNTGLRDLPPARGASVWYAYSASEQFPELGTGGGGPMSGPVYAYDPANPNKAKFPEYFDGKWFNYELTRQWFKTFSIQEKDQTFTDPRFAPAKAGDLQSINSVFGDMKWNQPFDADFGPDGALYVIDFGLGSGTGRGGSNEGAGIYRIDYVADSRLPDARVAATPDSGSAPLAVTFSSAGSGLPDGKPVTYAWDFDGDGTTDSTDANPKHTYTKNGVFTARLTVTGPTGLTGLAVQDITVGNTRPKVTIQQPPSGGTFSFGDTIPFKIKVTDREDGRPIDCSRVVVQSQLGHDSHLHPLDNYTGCAGEIVTDAGDSHGPGQNLYYGISAQYEDKGGAGGVPALTGSASLSLRTSFREAEHFTKTGGAHDGVVVASRADASGGKRLTEIEDGDWVSFDPVHLKGVDSVTVGAASGGIGGDVEFRVGSPTGKLLGKVSVPNTGDWGNVVSPTTQLADYDGTFPLYAVFTNPQWSADKPDLFAVDWLHFNGPGVEKRAGAKVKVTAAPESGAPPLTVALKGTVKLPEGRTAASYHWDFGDNVKPGGTQGADAQHAYARAGAYTAHLTVTDDKGDTTTGSVRITVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-09-29" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K3S4</accession>
    <name>A0A2M9K3S4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CG723_03165</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CB01635</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000001">
        <property type="protein sequence ID" value="PJN13786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN13786">
        <property type="protein sequence ID" value="PJN13786"/>
        <property type="gene ID" value="CG723_03165"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="25"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="63"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="94"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="118"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="154"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="181"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="252"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="278"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="314"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="340"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="385"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="408"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="248"/>
            <end position="440"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PJN13786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="440" mass="47632" checksum="CD7F08C22AFE4677" modified="2018-04-25" version="1">MTDENGRVYRVGETDRDILGHSRKFMVYLPWVAMMAISVSEYAYGSAEDTLSSAHGWTQSNTFWILSVWVFFQAGIAFPAGWMREKGILTAKRATMVGAFLCLFGFLALSHFNNVWLAILGFGVIGGLGSGLVYSTCINMVGKWFPERKGGKTGFVNGGFAYGSLPFIFIFNYAFDTSNYHRVLDMIGVYVLVVVLACAFFFRDPPKNWWPHEVDPLKKSGSDKEAKSLAKNPPAVRQFTPMEAVRTGMLPLMWFSLVLTAGVSIFGISFQVDFAKEVGFGPLVAASSMGVMAVINGVGRAVVGWLSDIWGRKVSLVFVIVVLGLAQFGVIWAGDIHSEWLFLFFAFLSGFGGGAFYPMFAALTPDYFGENYNATNYGLVYSGKLVSGLFGGGLGSMVVAAWGYNGAYALAGGVSMVAAAVALLLRQPGGEQAEKVVATA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JEI0</accession>
    <name>A0A2M9JEI0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MarR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_45545</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000057">
        <property type="protein sequence ID" value="PJN05306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN05306">
        <property type="protein sequence ID" value="PJN05306"/>
        <property type="gene ID" value="CG723_45545"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000835">
        <property type="entry name" value="HTH_MarR-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01047">
        <property type="entry name" value="MarR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00598">
        <property type="entry name" value="HTHMARR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00347">
        <property type="entry name" value="HTH_MARR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50995">
        <property type="entry name" value="HTH_MARR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH marR-type" evidence="1">
        <location>
            <begin position="1"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN05306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="120" mass="12842" checksum="E56F845DC96FC633" modified="2018-04-25" version="1">MSLTSAATLATLDRTGPRRITDLAAVEGVTQPAMTALVRVMEESGLVERRGDASDKRVTLVCLTEAGASYARTRRQAGVHAFERLIGELTGDEVEALVAALPALKHLAELESQDREGPKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-09-29" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JEK0</accession>
    <name>A0A2M9JEK0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CG723_45460</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CB01635</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000054">
        <property type="protein sequence ID" value="PJN05326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN05326">
        <property type="protein sequence ID" value="PJN05326"/>
        <property type="gene ID" value="CG723_45460"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004638">
        <property type="entry name" value="EmrB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00711">
        <property type="entry name" value="efflux_EmrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="37"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="67"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="96"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="127"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="151"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="184"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="213"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="257"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="288"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="316"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="348"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="392"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="421"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="1"/>
            <end position="445"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PJN05326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="463" mass="47383" checksum="061FA5DBBC81BEAE" modified="2018-04-25" version="1">MLVVTCLGQFMVLLDNTIVGAALPDMQHRLDAGLTGLQWIVDAYVLLVAMLLLSGGVFADRFGRKRVYLSGVAVFTAASVLCSIAPSVGWLVAGRVLQGVGAAALSPASLALLVAAHPAPQERVRAIGLWAGLSGIGLAAGPVAGGVLAQAFGWPAIFLVNVPIGVVLLVAGRRVLEESRNPDARALDIPGTILSVLGVGTLAYALIEGGSRGWTSPVILGGFAAAAVLLAAFVAVERRHPAPMLPPGLFRQRLFTVSNSAMIVVGFALMGSSFFFSQFFVYVQGSSILRAGLQTLPATLAMVVVSPFAGRLAARYSYRSIVTSGLALAGLGLLALGGVHADTGYANVWWRLATVGVGFALTMSPLTGAAIQAVDPQEGGLASGISSTTRQIGAVLGVAVLGAVVRARQSGGASFEAGLDSAFAVAGAVTLATAVCTGLWLVKFRPTPAPAPQRPDLSARRTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JEP0</accession>
    <name>A0A2M9JEP0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CG723_45270</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000052">
        <property type="protein sequence ID" value="PJN05348.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN05348">
        <property type="protein sequence ID" value="PJN05348"/>
        <property type="gene ID" value="CG723_45270"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PJN05348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="75" mass="7585" checksum="CDF1164971E343E4" modified="2018-04-25" version="1">MVADDLDDGAADLAVSFFMAGQREVRFVGHAEVGAQDVDADLALFCPIIGEAGEGVDADEADSGLVVAECSAAVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JES4</accession>
    <name>A0A2M9JES4_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Porphobilinogen deaminase</fullName>
            <shortName evidence="6">PBG</shortName>
            <ecNumber evidence="6">2.5.1.61</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Hydroxymethylbilane synthase</fullName>
            <shortName evidence="6">HMBS</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Pre-uroporphyrinogen synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">hemC</name>
        <name evidence="9" type="ORF">CG723_45115</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CB01635</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 6">Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>H2O + 4 porphobilinogen = hydroxymethylbilane + 4 NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:13185"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:57845"/>
            <dbReference type="ChEBI" id="CHEBI:58126"/>
            <dbReference type="EC" id="2.5.1.61"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>dipyrromethane</name>
            <dbReference type="ChEBI" id="CHEBI:60342"/>
        </cofactor>
        <text evidence="6">Binds 1 dipyrromethane group covalently.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Monomer.</text>
    </comment>
    <comment type="miscellaneous">
        <text evidence="6">The porphobilinogen subunits are added to the dipyrromethane group.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 6">Belongs to the HMBS family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.61" evidence="6"/>
    <dbReference type="EMBL" id="NNBL01000050">
        <property type="protein sequence ID" value="PJN05391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN05391">
        <property type="protein sequence ID" value="PJN05391"/>
        <property type="gene ID" value="CG723_45115"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004418">
        <property type="term" value="F:hydroxymethylbilane synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018160">
        <property type="term" value="P:peptidyl-pyrromethane cofactor linkage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006779">
        <property type="term" value="P:porphyrin-containing compound biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00260">
        <property type="entry name" value="Porphobil_deam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000860">
        <property type="entry name" value="HemC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022419">
        <property type="entry name" value="Porphobilin_deaminase_cofac_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022417">
        <property type="entry name" value="Porphobilin_deaminase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022418">
        <property type="entry name" value="Porphobilinogen_deaminase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036803">
        <property type="entry name" value="Porphobilinogen_deaminase_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11557">
        <property type="entry name" value="PTHR11557"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01379">
        <property type="entry name" value="Porphobil_deam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03900">
        <property type="entry name" value="Porphobil_deamC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001438">
        <property type="entry name" value="4pyrrol_synth_OHMeBilane_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00151">
        <property type="entry name" value="PORPHBDMNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54782">
        <property type="entry name" value="SSF54782"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00212">
        <property type="entry name" value="hemC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00533">
        <property type="entry name" value="PORPHOBILINOGEN_DEAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0627">Porphyrin biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Porphobil_deam" evidence="7">
        <location>
            <begin position="6"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="domain" description="Porphobil_deamC" evidence="8">
        <location>
            <begin position="229"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="modified residue" description="S-(dipyrrolylmethanemethyl)cysteine" evidence="6">
        <location>
            <position position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00260"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF03900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PJN05391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="319" mass="33267" checksum="FA503A4C696C171E" modified="2018-04-25" version="1">MTDRALRLGTRRSKLAMAQSGRVAEAVRQVTGRPVELVEITTYGDTSREQLAQIGGTGVFVVALREALLRGDVDFAVHSLKDLPTTPHPDLTLAAVPLREDPRDVLVARDGLTFAQLPDGARIGTGAPRRMSQLNAYARSHGMHIETVPIRGNIDTRVGYVHNGELDAVVLAAAGLNRIGRIGEVTDFLAVDTVLPAPGQGALAVECSASNADLAAMLGELDDSFTRVAVTAERSLLAALEAGCSAPVGALADLLADGQIANEMRLRGVVGTTDGSALVQLSTTGPVPETEDQALALGRELAAEMLAKGAAGLMGERAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-05-25" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JFG7</accession>
    <name>A0A2M9JFG7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NADPH:quinone reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_43785</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000044">
        <property type="protein sequence ID" value="PJN05619.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN05619">
        <property type="protein sequence ID" value="PJN05619"/>
        <property type="gene ID" value="CG723_43785"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="PKS_ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002364">
        <property type="entry name" value="Quin_OxRdtase/zeta-crystal_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01162">
        <property type="entry name" value="QOR_ZETA_CRYSTAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PKS_ER" evidence="1">
        <location>
            <begin position="12"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN05619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="306" mass="32041" checksum="FD00261B297ECD52" modified="2018-04-25" version="1">MQAITVQDRDAGVSGLSLSELPYPHAAENDVIVEVHAAGFTPGELDWPGTWSDRAGRDRTPSVPGHELSGVVTELGYGTTGLTVGQRVFGLTDWARNGSLAQYTAVEARNLAPLPADVDHVTAAALPISGLTAWQALFDHAHLVTGQSVLIHGAAGGVGSIAVQLAREVGARVIGTGRAGDRDTALGLGAEAFVDLQAEKLEDIGEVDVVFDVIGGEILERSTALVRPGGTLVTIAEPVTVHPRDGRAVFFVVEPDRARLAGLAQRLRDGRLKPIVGAVRPLAEAASAFTPDKRTPGKTIIRVTED</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-05-25" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JFJ1</accession>
    <name>A0A2M9JFJ1_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Lysine N-acyltransferase MbtK</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Mycobactin synthase protein K</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CG723_43425</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CB01635</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Acyltransferase required for the direct transfer of medium- to long-chain fatty acyl moieties from a carrier protein (MbtL) on to the epsilon-amino group of lysine residue in the mycobactin core.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Siderophore biosynthesis; mycobactin biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the peptidase S45 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000043">
        <property type="protein sequence ID" value="PJN05665.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN05665">
        <property type="protein sequence ID" value="PJN05665"/>
        <property type="gene ID" value="CG723_43425"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00011"/>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016811">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017000">
        <property type="term" value="P:antibiotic biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019290">
        <property type="term" value="P:siderophore biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1400.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.439.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019432">
        <property type="entry name" value="Acyltransferase_MbtK/IucB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043147">
        <property type="entry name" value="Penicillin_amidase_A-knob"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023343">
        <property type="entry name" value="Penicillin_amidase_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043146">
        <property type="entry name" value="Penicillin_amidase_N_B-knob"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002692">
        <property type="entry name" value="S45"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34218">
        <property type="entry name" value="PTHR34218"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01804">
        <property type="entry name" value="Penicil_amidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01006">
        <property type="entry name" value="AlcB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="SSF56235"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0865">Zymogen</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="8">
        <location>
            <begin position="707"/>
            <end position="874"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003818"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00020586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00031122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PJN05665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="880" mass="96147" checksum="92A02A7AFE305D6A" modified="2018-04-25" version="1">MSVEVYRDEWGIPHLRADSARELAHAQGRNAAADRAWQIEVERHRSQGTSAAFLGQEAAGWDRFARQARIDDTARRCYRALDEETRGWLDAYVAGVDAGLRELGGSAPEFARAGLEPGHWQPWTPLGIWLSTHILFTGLPGKLWRDEVVRRIGPGAVGLFATDGPGTSGSNGWLVTGDRTATGGPLIAGDPHRYIEAPGVYQQIRLACPDFDVVGLAVPGVPGIGHFGHTGTVAWAITNAMADYQDLYRERLRRLPDGGVEAFGPDGWRPASRSVETFEVAGGRPQEVEVVETERGTVVIGGPDEGEGIALRQPPRVREDLGFAALPALLRARTVGDVDRAFDRWAEPVNVVQAADTEGGLLHRVAGAVPERDPENLLRVVPAHEPRYAWRGLREMPREPVGTVAVMANQRGLAAPLGIEFAPPHRADRIRELLDAREEWTAPGMATVHTDTRLASARPLLDLVARLDGLGPEAAALRRRLLAWDRHMDADSADAAAYARVRAAVVRKLAAHSAFAPLAGMGEAYPEVFRPWLALAPRIAFALETLLTTSQFPDVDRETVVREAVEEAAGATATGETWGDRHRLAAWRALPDGDEVGPGLPGDHDCVLSTSSVPGVTDLSARGPAARYVWDVADRANSLWVVPLGACGIPGSPHRRDQLPLWLRGELVPVVTDWARLTREDHPHQEDHPHQKEHRVYEQTVEGFGTVSVSPVDPAADLDVLHGWVREERARFWGMEGASREQVRETYEHLDSLTTHHAHLVRLNGEPVALFQTYEPEADRVSECYEVEDGDIGVHFLIAPAGDGAVSGFTGALMTVLIAYALEGHGKRRIVVEPDARNAKAVALLERAGFELGPEIVLPEIDLPEVFLPEKRARIAFLKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JFS6</accession>
    <name>A0A2M9JFS6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_43585</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000043">
        <property type="protein sequence ID" value="PJN05692.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN05692">
        <property type="protein sequence ID" value="PJN05692"/>
        <property type="gene ID" value="CG723_43585"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="48"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN05692.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="78" mass="8364" checksum="F626C2769108A535" modified="2018-04-25" version="1">MIPIGMSAQVRPAARSTADRALNTLRRWARQAAKPVKAAITRHGNVMKKPGAATVPTPDHVPEQQERTAAPGDVSARE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JFX9</accession>
    <name>A0A2M9JFX9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CG723_42935</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CB01635</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000041">
        <property type="protein sequence ID" value="PJN05789.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN05789">
        <property type="protein sequence ID" value="PJN05789"/>
        <property type="gene ID" value="CG723_42935"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003838">
        <property type="entry name" value="ABC3_permease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038766">
        <property type="entry name" value="Membrane_comp_ABC_pdt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30287">
        <property type="entry name" value="PTHR30287"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02687">
        <property type="entry name" value="FtsX"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014832019" evidence="7">
        <location>
            <begin position="34"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="62"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="114"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="157"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="202"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="234"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="285"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="326"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="373"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="410"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="domain" description="FtsX" evidence="8">
        <location>
            <begin position="91"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="domain" description="FtsX" evidence="8">
        <location>
            <begin position="352"/>
            <end position="438"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PJN05789.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="448" mass="46145" checksum="68C4A9F6D8E7F519" modified="2018-04-25" version="1">MTTGLARAALTAHRPAFVGTAVAALFAATVVSASTTVLLATSTDGLPAGARHRITENGVGDIAAVLLIGSIYMSIFVVVSTMGTAVTQQHRELALVRAIGARPRQVRRAVARQALAASVPAALAGFAAGALLARAWFSGMVTHGLIPPGVPFRFSWVALPVCLGVAVVTSTAAALLSSLRFSLLRPARALSEAAAGRRRLGLLRAPLGLVAVAGACFLSVLLSRQDAEEAGQGAFLVLILFCVGVGLLGPRIVGPAAWLVSALVGRFGASARLAMLNVRSQPRRFSAAVVPLVLVVGFGLTKVALHTTAQHRTGSAGSTGEVWLDYMGTALYAGFAAIAAANTLAMISFERRRDVALLRVVGTQRGQVRSMAAWEAVVVAGTALLLGALIALVTLAPILDTVFGSPVPYVPWTLAAGTVAGTLLLTLLATGVPVRSVMRHRAITVVRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JG37</accession>
    <name>A0A2M9JG37_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Phosphoribosylamine--glycine ligase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CG723_42450</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000040">
        <property type="protein sequence ID" value="PJN05849.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN05849">
        <property type="protein sequence ID" value="PJN05849"/>
        <property type="gene ID" value="CG723_42450"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0436">Ligase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PJN05849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="492" mass="54918" checksum="45A9641E0FDF7601" modified="2018-04-25" version="1">MRRWESGALAHAVSDPFGQGPLPWLRGSEHYFDDTGQVVPWYVDHAPQPGASTIATSIPSPRTGGPRMADDVHRQIKGFTSTGAAAPGEAIDFHITVDPPQQFSVDIYRIGHYGGDGASKIITSPRLSGIVQPAPLTADRTVSCHHWWLSWRLQIPSFWNVGAYVAVLTTVDGYRSHVPFTVRDSRPADLLLLLPDVTWQAYNLYPEDGHTGASLYHAWDQEGRLLGEGDAATTVSFDRPYAGAGLPLHVGHAYDFIRWAERYGYDLAYADARDLHAGRIDPTRYRGLVFPGHDEYWSTPMRRTTEVAREHGTSLVFLSANTMYWQVELGPSPSGVPDRLLTCHKRRAPGKSALWREIDRPEQQLMGIQYAGRVPEPHPLVVRNADHWLWEATGAHEGDEIDGLVAGEADRYFPRTALPEHEDRILLAHSPYRDSERAPRHQETSLYRAPSGSLVFASGTFAWSPALDRPGHVDPRIQRATANLLDRICKRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-09-29" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JG69</accession>
    <name>A0A2M9JG69_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Peptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_42285</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C56 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000039">
        <property type="protein sequence ID" value="PJN05868.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN05868">
        <property type="protein sequence ID" value="PJN05868"/>
        <property type="gene ID" value="CG723_42285"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006286">
        <property type="entry name" value="C56_PfpI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002818">
        <property type="entry name" value="DJ-1/PfpI"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42733">
        <property type="entry name" value="PTHR42733"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01965">
        <property type="entry name" value="DJ-1_PfpI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01382">
        <property type="entry name" value="PfpI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51276">
        <property type="entry name" value="PEPTIDASE_C56_PFPI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DJ-1_PfpI" evidence="2">
        <location>
            <begin position="4"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN05868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="188" mass="20912" checksum="6C9D6E161CAE0F83" modified="2018-04-25" version="1">MAPKILLVTGDAAESLEVLYPYQRLREEGYDVHIAAPERKKLQFVVHDFEPGFDTYTEKPGYTWPADLAFAEVEPEQYVAVVIPGGRAPEYLRNDPELRKILKSFFDADKPVAQICHGPLLTAAVDGLRGRRVTAYPALEPDMQAAGAAFRDAEVVVDGTLVSSRAWPDHSGWMREFLTVLRAKAPVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JG70</accession>
    <name>A0A2M9JG70_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">TetR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CG723_42335</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000039">
        <property type="protein sequence ID" value="PJN05876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN05876">
        <property type="protein sequence ID" value="PJN05876"/>
        <property type="gene ID" value="CG723_42335"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023772">
        <property type="entry name" value="DNA-bd_HTH_TetR-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011075">
        <property type="entry name" value="TetR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16859">
        <property type="entry name" value="TetR_C_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01081">
        <property type="entry name" value="HTH_TETR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="3">
        <location>
            <begin position="37"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="60"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PJN05876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="219" mass="23125" checksum="E2597A865E0179E7" modified="2018-04-25" version="1">MTTNADSSPELSASLEQGGPPSPARRRAPAGAAVLREDVTDAIRAAVFEELAAVGYARMSIEGIARRAGVGKTAVYRRWRSKLHLVLDLVSAIAVQGLPAPDTGSLEGDLRLLYEVTSRALRHPVAGQIIPDLQAEAARNPEIAEAMQKALREGQHGVANGIVRSAAARGEVRADLDEDLALDLISGPLYWRAVVVRTPLPKGYLGKLASATAAGLRAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JGB5</accession>
    <name>A0A2M9JGB5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">HAD family hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_42975</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000041">
        <property type="protein sequence ID" value="PJN05797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN05797">
        <property type="protein sequence ID" value="PJN05797"/>
        <property type="gene ID" value="CG723_42975"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041065">
        <property type="entry name" value="GNAT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006357">
        <property type="entry name" value="HAD-SF_hydro_IIA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18407">
        <property type="entry name" value="GNAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13344">
        <property type="entry name" value="Hydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GNAT_like" evidence="1">
        <location>
            <begin position="289"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF18407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN05797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="342" mass="35249" checksum="0BBFF5E5B5C81C9D" modified="2018-04-25" version="1">MSQTVRTRPESSERALNEAYDTALLDLDGVVYAGGDAIAHAPESLAVARGAGMGLAYVTNNALRTPDAVAEHLTELGIPTEAADVITSAQAVARLISEQVPDGSRVLVIGGEGLRVALRERGLEPVDSADDEPVAVVQGYGGPDLAWGRFAEACYAIARGVPWFASNTDLTIPSARGIAPGNGAAVEVVRIATGAQPQVAGKPLSPMHRETILRTGAERPLVIGDRLDTDIEGAFNGEVDSLLVLTGVTDGAQLLAAPPQHRPTYVDVDLRGLLTGQPDVVAQGDGFACGGWLAIARDEHLELEGDGEAIDGLRALCAAAWTAAGDGTCGLDGAKALARLGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JGF7</accession>
    <name>A0A2M9JGF7_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">tRNA (guanine-N(7)-)-methyltransferase</fullName>
            <ecNumber evidence="1">2.1.1.33</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">tRNA (guanine(46)-N(7))-methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">tRNA(m7G46)-methyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">trmB</name>
        <name evidence="3" type="ORF">CG723_42660</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>guanosine(46) in tRNA + S-adenosyl-L-methionine = N(7)-methylguanosine(46) in tRNA + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:42708"/>
            <dbReference type="Rhea" id="RHEA-COMP:10188"/>
            <dbReference type="Rhea" id="RHEA-COMP:10189"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74269"/>
            <dbReference type="ChEBI" id="CHEBI:74480"/>
            <dbReference type="EC" id="2.1.1.33"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">tRNA modification; N(7)-methylguanine-tRNA biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class I-like SAM-binding methyltransferase superfamily. TrmB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.33" evidence="1"/>
    <dbReference type="EMBL" id="NNBL01000040">
        <property type="protein sequence ID" value="PJN05837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN05837">
        <property type="protein sequence ID" value="PJN05837"/>
        <property type="gene ID" value="CG723_42660"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00989"/>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008176">
        <property type="term" value="F:tRNA (guanine-N7-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01057">
        <property type="entry name" value="tRNA_methyltr_TrmB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003358">
        <property type="entry name" value="tRNA_(Gua-N-7)_MeTrfase_Trmb"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23417">
        <property type="entry name" value="PTHR23417"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02390">
        <property type="entry name" value="Methyltransf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00091">
        <property type="entry name" value="TIGR00091"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51625">
        <property type="entry name" value="SAM_MT_TRMB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="1 3" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0819">tRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="1">
        <location>
            <begin position="247"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="99"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="124"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="151"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="174"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="178"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="210"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN05837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="277" mass="30327" checksum="26B3FD16AC2BB66E" modified="2018-04-25" version="1">MSESPHTPEAHTPEAAGPEAPAPARAKGEPRFPDGPAPDPAGSHFERRIRSFQPRRSRVTTGQADALQRLWPAWGLDIDGQRVLDLDELFDGRKRVVLEIGFGMGEATAQMAADDPDTGILAVDVHTPGQGNLLGLAERNGLTNVRVANGDAIILIREMLPAASLDGLRVYFPDPWPKKRHHKRRLIQPEFLSLAKVPLKPGALVHCATDWEPYAEQMLEVLTEHPDYENTQADGGYAPRPAFRPLTRFEGQGLDKGHVVHDLLFLRAAHAPATAAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JGN8</accession>
    <name>A0A2M9JGN8_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF35_N domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_41945</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000037">
        <property type="protein sequence ID" value="PJN06013.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN06013">
        <property type="protein sequence ID" value="PJN06013"/>
        <property type="gene ID" value="CG723_41945"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022002">
        <property type="entry name" value="DUF35_Znr_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12172">
        <property type="entry name" value="DUF35_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF35_N" evidence="1">
        <location>
            <begin position="18"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN06013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="127" mass="13560" checksum="6AAB0899E93154D1" modified="2018-04-25" version="1">MGHDVSHAAPTGPDGTGLTIQRCRWCGTASFRRLLCPVCASSDLQAEHSDGLGVVVQSSVVNRYTGTARNESLVRFPEGFVFRCRVVGAAPNLVWIGARVRPVAGSDPDAGEVVFELCDTGGRTDWQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JHB5</accession>
    <name>A0A2M9JHB5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">MxaD family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CG723_40265</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000033">
        <property type="protein sequence ID" value="PJN06255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN06255">
        <property type="protein sequence ID" value="PJN06255"/>
        <property type="gene ID" value="CG723_40265"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019587">
        <property type="entry name" value="Polyketide_cyclase/dehydratase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10604">
        <property type="entry name" value="Polyketide_cyc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PJN06255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="165" mass="17938" checksum="A511ABDD8AB3C5AB" modified="2018-04-25" version="1">MARRLKPVGLEFTESAPLRLVFAREVSAPPQAVFRALSEDVTGWPEWFSAVTLARPTDGGAGREVRLRGGTRMRETILAAEPDTVYAYRVDETNAPGIRALVEEWRLTPSGVGGTRVQWTFAADGAAAFRVGLRLGRAGLGRAFRDAVAALDRRIAVNSRDSRAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JHD3</accession>
    <name>A0A2M9JHD3_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">S-adenosylmethionine synthase</fullName>
            <shortName evidence="11">AdoMet synthase</shortName>
            <ecNumber evidence="11">2.5.1.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">MAT</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Methionine adenosyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">metK</name>
        <name evidence="17" type="ORF">CG723_39800</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">CB01635</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>ATP + H2O + L-methionine = diphosphate + phosphate + S-adenosyl-L-methionine</text>
            <dbReference type="Rhea" id="RHEA:21080"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="EC" id="2.5.1.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </cofactor>
        <text evidence="11">Binds 1 potassium ion per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="11">Binds 2 divalent ions per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 11">Amino-acid biosynthesis; S-adenosyl-L-methionine biosynthesis; S-adenosyl-L-methionine from L-methionine: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Homotetramer; dimer of dimers.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11 12">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11 13">Belongs to the AdoMet synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.6" evidence="11"/>
    <dbReference type="EMBL" id="NNBL01000032">
        <property type="protein sequence ID" value="PJN06290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN06290">
        <property type="protein sequence ID" value="PJN06290"/>
        <property type="gene ID" value="CG723_39800"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00315">
        <property type="reaction ID" value="UER00080"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004478">
        <property type="term" value="F:methionine adenosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006730">
        <property type="term" value="P:one-carbon metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006556">
        <property type="term" value="P:S-adenosylmethionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00086">
        <property type="entry name" value="S_AdoMet_synth1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022631">
        <property type="entry name" value="ADOMET_SYNTHASE_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022630">
        <property type="entry name" value="S-AdoMet_synt_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022629">
        <property type="entry name" value="S-AdoMet_synt_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022628">
        <property type="entry name" value="S-AdoMet_synt_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002133">
        <property type="entry name" value="S-AdoMet_synthetase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022636">
        <property type="entry name" value="S-AdoMet_synthetase_sfam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11964">
        <property type="entry name" value="PTHR11964"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02773">
        <property type="entry name" value="S-AdoMet_synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02772">
        <property type="entry name" value="S-AdoMet_synt_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00438">
        <property type="entry name" value="S-AdoMet_synt_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000497">
        <property type="entry name" value="MAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55973">
        <property type="entry name" value="SSF55973"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01034">
        <property type="entry name" value="metK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00376">
        <property type="entry name" value="ADOMET_SYNTHASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00377">
        <property type="entry name" value="ADOMET_SYNTHASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 11 12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6 11 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4 11" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="10 11 12" id="KW-0630">Potassium</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11 17" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="S-AdoMet_synt_N" evidence="14">
        <location>
            <begin position="3"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="domain" description="S-AdoMet_synt_M" evidence="15">
        <location>
            <begin position="128"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="domain" description="S-AdoMet_synt_C" evidence="16">
        <location>
            <begin position="253"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="region of interest" description="Flexible loop" evidence="11">
        <location>
            <begin position="99"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="15"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="17"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="43"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="56"/>
        </location>
        <ligand>
            <name>L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="99"/>
        </location>
        <ligand>
            <name>L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="177"/>
            <end position="179"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="250"/>
            <end position="251"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="259"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="265"/>
            <end position="266"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="282"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <note>ligand shared between two neighboring subunits</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="286"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <note>ligand shared between two neighboring subunits</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="290"/>
        </location>
        <ligand>
            <name>L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU004462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF02772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF02773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="PJN06290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="405" mass="43649" checksum="396C61D5844B0E73" modified="2018-04-25" version="1">MSSYLFTSESVTEGHPDKIADQISDTILDALLREDPTSRVAVETLITTGQVHIAGEVTTKAYAPIAQLVRDTILGIGYDSSAKGFDGESCGVSVSIGAQSPDIAQGVDVAYEARAEGAAADGDELDRQGAGDQGLMFGYATNETPTLMPLPIELAHRLSRRLTEVRKNGTLPYLRPDGKTQVTIEYRGSRPVRLDTVVVSSQHAPDIDLDTLLAPDIKEHVVEHVLARLAEDGIKLETDEYRLLVNPTGRFEIGGPMGDAGLTGRKIIIDTYGGMARHGGGAFSGKDPSKVDRSAAYAMRWVAKNVVAAGLADRCEVQVAYAIGKAEPVGLFIETFGTGRVAQTRIEQAVREVFDLRPAAIIRDLDLLRPIYAQTAAYGHFGRELSDFTWERTDRAPQLRAAAGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JHP5</accession>
    <name>A0A2M9JHP5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Multidrug ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CG723_39635</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000031">
        <property type="protein sequence ID" value="PJN06372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN06372">
        <property type="protein sequence ID" value="PJN06372"/>
        <property type="gene ID" value="CG723_39635"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="SSF90123"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="37"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="70"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="163"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="264"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="10">
        <location>
            <begin position="38"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="9">
        <location>
            <begin position="358"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="395"/>
            <end position="402"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PJN06372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="606" mass="65386" checksum="F48F9A9D54E7674C" modified="2018-04-25" version="1">MRHDEPGWTPSPSDATSPEPRQMRRILALFRPYRARLALVGLLVGAASLVSVATPFLLKEILDTAIPQGRTGLLSLLALGMILSAVVTSVFGVLQTLISTTVGQRVMHDLRTAVYGRLQRMSLAFFTRTRTGEVQSRIANDIGGMQATVTSTATSLVSNLTSVVATIVAMVALDWRLTAVSLVLLPLFVWISRRVGRERKKIATERQKQMAAMAATVTESLSVSGILLGRTMGRADSLTRSFADESDQLVGLEVRSNMAGRWRMAVITVVMAAMPAVIYWVAGVALQLGGPSVSIGTLVAFVSLQQGLFRPTVSLLATGVQIQTSLALFQRIFEYLDLPIDITEPEQPVRLDTIKGEVRFEDVEFRYDAADGKSAAILDGIDVTVPAGGSLAVVGPTGSGKSTLSYLVPRLYDVTGGRVTLDGVDVRDLDFDTLARAVGVVSQETYLFHASVAENLRFAKPDATEEELHAAARAAQIHEHIASLPDGYDTVVGERGHRFSGGEKQRLAIARTILRDPPILILDEATSALDTRTEFAVQEAIDALSANRTTVTIAHRLSTIRGADQIVVLDGGQVAERGTHEELLERDGRYAALVRRDSQLEPASPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JI76</accession>
    <name>A0A2M9JI76_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">SAM-dependent methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_38265</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000028">
        <property type="protein sequence ID" value="PJN06553.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN06553">
        <property type="protein sequence ID" value="PJN06553"/>
        <property type="gene ID" value="CG723_38265"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransf_11" evidence="1">
        <location>
            <begin position="60"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN06553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="262" mass="28499" checksum="80DAF8C5292F3A81" modified="2018-04-25" version="1">MSTPPTPAGRPFDELVTEAAAAPVEGWDFSWFEGRATEERPSWGYARAMGERMGRASAGLDLQTGGGEVLASAPKLPPLIAASEGWPPNVAKASALLAPRGVVVVASREEAPLPFADGTFDLVTSRHPVKAPFAEIARVLMPGGTYFAQHVGPSSVFEVVEYFLGPQPEEVRNGRDPEGERAEAEAAGLEVVDLRAERLRIEFFDIGAVVHFLRKVIWMVPGFTVEAYRPLLLELHERLEKEGPFVAHSTRHLIEARKPITG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JI83</accession>
    <name>A0A2M9JI83_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="13">ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CG723_38640</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">CB01635</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000029">
        <property type="protein sequence ID" value="PJN06467.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN06467">
        <property type="protein sequence ID" value="PJN06467"/>
        <property type="gene ID" value="CG723_38640"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00060">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC_2_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000253">
        <property type="entry name" value="FHA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032030">
        <property type="entry name" value="YscD_cytoplasmic_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01061">
        <property type="entry name" value="ABC2_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00498">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16697">
        <property type="entry name" value="Yop-YscD_cpl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00240">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SSF49879"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50006">
        <property type="entry name" value="FHA_DOMAIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 8 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="563"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="636"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="680"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="709"/>
            <end position="727"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="778"/>
            <end position="800"/>
        </location>
    </feature>
    <feature type="domain" description="FHA" evidence="11">
        <location>
            <begin position="30"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="domain" description="FHA" evidence="11">
        <location>
            <begin position="171"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="12">
        <location>
            <begin position="257"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="67"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="138"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="291"/>
            <end position="298"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PJN06467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="810" mass="87582" checksum="1FDFFA82A08979A9" modified="2018-04-25" version="1">MAERPVSPTAPELVLETEAGPTVMSPSRDYHVGRDPLSDIVIDDVRVSWHHAVLRPVADHWSLEDEDSTNGTYTGGRRIHESGVGPGTVIRFGHPADGPRAVLVGHEPPPPPEPVAEHSADRVPDRIPDHVLDSVAAAPRAAERPSSVSMPGATGTFRQPTTVRPLPTRTVRIGRNADNDLVVDDLIVSRRHAELRARPDGTYEIVDLGSHNGTYLNGAQVSRARVSPGDVVGIGHSAFCLVGDTLQEFVDTGEVSLDVQGLAVTVDRGRKTLLDHVSFPVGEKCLLAVVGPSGAGKSTLLNALTGLRPADQGTVLYDGRDLYRDYAELRQRIGLVPQDDILHSQLTVHRALGYAAELRFPQDTERSERRDRVDEVVRELGLEQRAAQPIHSLSGGQRKRVSVALELLTKPSLLFLDEPTSGLDPGMDRSVMNMLRGLADDGRTVIVVTHSVLSLEVCDRLLVLAPGGKIAFYGPPGDALGFFGFEEWPEAFESFENDRDRGWAEEYNTSLFHRQYIVNSTAQPRLPNAPSAEVAPPPRTRSWGAQLRTLVRRYAAALSADRTFLAIMIALPFVMGAMVRALAGSRLTQESAMNALLLLCVGGVLTGAANAVRELVKERVIYQRERAVGLSRSAYLMSKVVVLGTITVLQAIVLTLVGLVGVDLNAPGGKGVLMPPLVEITLTVALLSFTAMMLGLLVSALVRKEEVTMPLLVLIAIIQVVFCGALLKLHGVPGIEQLSWLVPSRWAMGAMAGTVGLSRIVPGKLTSDPLFEHSTGVWLLNMGMLVVLSVVFGIAVARLLRRHEPAIMRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JIE1</accession>
    <name>A0A2M9JIE1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CG723_37840</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000027">
        <property type="protein sequence ID" value="PJN06649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN06649">
        <property type="protein sequence ID" value="PJN06649"/>
        <property type="gene ID" value="CG723_37840"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PJN06649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="90" mass="9980" checksum="C3A6BD2465B1B41C" modified="2018-04-25" version="1">MEQITVRSRPRVPAITCGSSATSTRLDRHLSVLGGPAVPQREAAEATLLMRELTSRDVAHERSSRGARVSRVSLFAPLRRLRRSLFGGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-05-25" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JIG7</accession>
    <name>A0A2M9JIG7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">L-idonate 5-dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CG723_38090</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CB01635</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000027">
        <property type="protein sequence ID" value="PJN06686.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN06686">
        <property type="protein sequence ID" value="PJN06686"/>
        <property type="gene ID" value="CG723_38090"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="ADH_N" evidence="4">
        <location>
            <begin position="30"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="domain" description="ADH_zinc_N" evidence="3">
        <location>
            <begin position="185"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PJN06686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="349" mass="35679" checksum="6AF682095947986B" modified="2018-04-25" version="1">MAGGDLMLGCVIHGAGDLRVDELPVPEPGPGQALVAVRYGGVCGSDLHYWRHGGVGDFRLREPMLLGHEVVGTVISYGDGATGPAPGTAVAVHPATPCGICPECVDGRRNVCRDTRYLGSAARTPHVQGGFAARITVPADQLRAVPAGLPLDRAALAEPLAVALHAVRRAGPVAGKHVLVTGAGPIGCLVVAAAKAAGAAHVTATDLLPEALRYAELAGADTLVRADDPADKGWPDEAHAAVEASGVAAGLDSCLRQVRRGGVVVQLGMLPPGQSPFAGNLVVSREIELRGAFRFDTEFDDALRLLAEQPGLAELISAVVPVAEAESAFVLAADRARACKVLLDFGAGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-09-29" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JIK4</accession>
    <name>A0A2M9JIK4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CG723_38000</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CB01635</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000027">
        <property type="protein sequence ID" value="PJN06715.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN06715">
        <property type="protein sequence ID" value="PJN06715"/>
        <property type="gene ID" value="CG723_38000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="42"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="77"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="104"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="142"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="177"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="231"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="268"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="297"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="322"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="361"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="390"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="4"/>
            <end position="413"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PJN06715.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="417" mass="44020" checksum="CB3D9D2A4F3E6BAE" modified="2018-04-25" version="1">MRRVAVASFIGTAIEFYDFYVYGTAAALVLNEAFFPNLSSLNATLASFSTYAVAFAARPIGSLLFGHFGDRVGRKSVLVASLLLMGLSTACVGLLPGYGTLGVWAPLLLVLLRFLQGVGLGGEWGGAALLAVEHAPRGKRGLFAAFPQLGPSVGFFAATGIFWILSTTLDDEAFHSWGWRVPFLLSFLLVAVGLFVRLKISETPVFAKVMKEQEASKAPALEVFKRHPREILLGAGGMVVAYGLFYTATTYCLAYGTTTLGVPRNTMLAVSLVACLFLAAGTWLAATRSDAGGRRKLVLAGAGLAVVWGLVLFPLMDTEQPVLIALALGGALFCMGVVYGPMGAYLPELFGVRVRYSGASFAYNLGGVLGGAVAPLVATRLQGEFGSSSVGWYVSAMAVVSLLCVLALPETRERELG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JJC4</accession>
    <name>A0A2M9JJC4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">GntR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CG723_36425</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000024">
        <property type="protein sequence ID" value="PJN06975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN06975">
        <property type="protein sequence ID" value="PJN06975"/>
        <property type="gene ID" value="CG723_36425"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07377">
        <property type="entry name" value="WHTH_GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.530">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011711">
        <property type="entry name" value="GntR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008920">
        <property type="entry name" value="TF_FadR/GntR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07729">
        <property type="entry name" value="FCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
        <property type="entry name" value="GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00895">
        <property type="entry name" value="FCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00345">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48008">
        <property type="entry name" value="SSF48008"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50949">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH gntR-type" evidence="4">
        <location>
            <begin position="1"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PJN06975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="229" mass="24834" checksum="1C9713346B896B3F" modified="2018-04-25" version="1">MSAVEKAFHGLRHMIADGRLTAGARMPPEADLCAELGVSRGPLREAVRMLAALRVVEPRHGSGTYVSALRPEDIIGSLSLTVDLLPLPGLLEVYELRRVLEAHAASQAAARVGAEALERMHAHLAAMEATDDPAEVSDLDHRFHSEVARVAGNPALDSLLTVFRTRSRRHQIFTLPEGPDIKRVSDAGHREIVGAISRHDPVAAASAAAAHIAHSEKWLRHLLDQERQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JJH1</accession>
    <name>A0A2M9JJH1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CG723_36265</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CB01635</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the tRNA methyltransferase O family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000024">
        <property type="protein sequence ID" value="PJN07019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN07019">
        <property type="protein sequence ID" value="PJN07019"/>
        <property type="gene ID" value="CG723_36265"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023370">
        <property type="entry name" value="TrmO-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036413">
        <property type="entry name" value="YaeB-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036414">
        <property type="entry name" value="YaeB_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01980">
        <property type="entry name" value="TrmO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF118196">
        <property type="entry name" value="SSF118196"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51668">
        <property type="entry name" value="TSAA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="domain" description="TsaA-like" evidence="3">
        <location>
            <begin position="12"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00033753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PJN07019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="164" mass="18318" checksum="4EF2864A1E69C566" modified="2018-04-25" version="1">MVRRAGARLWRSSPIGEVVEGRAEIADDYWGGVESVIQLDEAEFPRDAVPGRAEFSHLVGVWHFDQASPGDVEYYVRSPRGNTQWPATGTFAHRNHRRPNQLAQSSPRLLKVDGLCLRVADLDAVVGTKIHDLSPHFTEMGPRGTVHELAWPGEMLADHWTDNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-05-25" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JJP3</accession>
    <name>A0A2M9JJP3_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Nicotinate-nucleotide diphosphorylase (carboxylating)</fullName>
            <ecNumber evidence="4">2.4.2.19</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Quinolinate phosphoribosyltransferase [decarboxylating]</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CG723_35795</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">CB01635</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in the catabolism of quinolinic acid (QA).</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Cofactor biosynthesis; NAD(+) biosynthesis; nicotinate D-ribonucleotide from quinolinate: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the NadC/ModD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.19" evidence="4"/>
    <dbReference type="EMBL" id="NNBL01000023">
        <property type="protein sequence ID" value="PJN07096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN07096">
        <property type="protein sequence ID" value="PJN07096"/>
        <property type="gene ID" value="CG723_35795"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00253">
        <property type="reaction ID" value="UER00331"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004514">
        <property type="term" value="F:nicotinate-nucleotide diphosphorylase (carboxylating) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009435">
        <property type="term" value="P:NAD biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01572">
        <property type="entry name" value="QPRTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1170.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004393">
        <property type="entry name" value="NadC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027277">
        <property type="entry name" value="NadC/ModD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036068">
        <property type="entry name" value="Nicotinate_pribotase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037128">
        <property type="entry name" value="Quinolinate_PRibosylTase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002638">
        <property type="entry name" value="Quinolinate_PRibosylTrfase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022412">
        <property type="entry name" value="Quinolinate_PRibosylTrfase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32179">
        <property type="entry name" value="PTHR32179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01729">
        <property type="entry name" value="QRPTase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02749">
        <property type="entry name" value="QRPTase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006250">
        <property type="entry name" value="NadC_ModD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51690">
        <property type="entry name" value="SSF51690"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00078">
        <property type="entry name" value="nadC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="5" id="KW-0662">Pyridine nucleotide biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="QRPTase_N" evidence="11">
        <location>
            <begin position="65"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="domain" description="QRPTase_C" evidence="10">
        <location>
            <begin position="155"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009400"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011944"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00033102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR006250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF02749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PJN07096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="324" mass="33622" checksum="F3B983EEFB0EBFB0" modified="2018-04-25" version="1">MSTPDLPLAESGGCGDGCGCGGADADMMECGLDPALAQLLADAGLDPVEVEDIAHMAIAEDLDGGVDVTTVATIPEDAVATADFTAREDGVVAGLRVAEAVLSVVCTDEFEVERHAEDGDRITAGQKLLSVTTRTRDLLTAERSALNILCRLSGIASATRAWADALEGTTAKVRDTRKTTPGLRSLEKFAVRMGGGVNHRMSLSDAALVKDNHVVAAGGVAQAFKAVRESFPDLAVEVEVDTLNQLREVVEAGADLILLDNFTPAETQEAVAIVAGRALLESSGRLTLANAREYAATGVDFLAVGALTHSSPILDIGLDLRAAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JJX1</accession>
    <name>A0A2M9JJX1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">TetR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CG723_34785</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000022">
        <property type="protein sequence ID" value="PJN07164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN07164">
        <property type="protein sequence ID" value="PJN07164"/>
        <property type="gene ID" value="CG723_34785"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039538">
        <property type="entry name" value="BetI_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023772">
        <property type="entry name" value="DNA-bd_HTH_TetR-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13977">
        <property type="entry name" value="TetR_C_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01081">
        <property type="entry name" value="HTH_TETR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0678">Repressor</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="3">
        <location>
            <begin position="10"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="2">
        <location>
            <begin position="33"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PJN07164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="208" mass="22511" checksum="3AD5B3671F91CE88" modified="2018-04-25" version="1">MARVSQEHLDARRRQILDGATLCFALNGFHATSMQDVLKSVNLSAGAVYRYFSGKEELIGAIVTEVLDEIRGVFESAGAESPPAPPDVLVGRVLGRILGMRPGLTHEGVSVFPRLMVQVWTETLRNDELSRVMREAYVGVRAAWVKIVEGYQAAGMMRADIPADDVARVMIATAQGFAAQQALFGEVHVPVETLQNGLRALMSMGAAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JK34</accession>
    <name>A0A2M9JK34_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 7">Elongation factor Tu</fullName>
            <shortName evidence="6">EF-Tu</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6 9" type="primary">tuf</name>
        <name evidence="9" type="ORF">CG723_35115</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CB01635</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000022">
        <property type="protein sequence ID" value="PJN07222.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN07222">
        <property type="protein sequence ID" value="PJN07222"/>
        <property type="gene ID" value="CG723_35115"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01884">
        <property type="entry name" value="EF_Tu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00118_B">
        <property type="entry name" value="EF_Tu_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041709">
        <property type="entry name" value="EF-Tu_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004161">
        <property type="entry name" value="EFTu-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031157">
        <property type="entry name" value="G_TR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009001">
        <property type="entry name" value="Transl_elong_EF1A/Init_IF2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004541">
        <property type="entry name" value="Transl_elong_EFTu/EF1A_bac/org"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004160">
        <property type="entry name" value="Transl_elong_EFTu/EF1A_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03144">
        <property type="entry name" value="GTP_EFTU_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03143">
        <property type="entry name" value="GTP_EFTU_D3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="SSF50447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50465">
        <property type="entry name" value="SSF50465"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00485">
        <property type="entry name" value="EF-Tu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00301">
        <property type="entry name" value="G_TR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 6 9" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="5 6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4 6" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="8">
        <location>
            <begin position="10"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="19"/>
            <end position="26"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="81"/>
            <end position="85"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="136"/>
            <end position="139"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU004061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PJN07222.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="392" mass="41347" checksum="4E083E527AEE2DB3" modified="2018-04-25" version="1">MPKTAYVRTKPHLNIGTMGHVDHGKTTLTAAITKVLAERGAGTFVPFDRIDRAPEEAARGITINIAHVEYETDTRHYAHVDMPGHADYVKNMVTGAAQLDGAILVVSALDGVMPQTAEHVLLARQVGVDHIVVALNKADAGDEELTDLVELEVRELLSAHGYGGDSVPVVRVSGLKALEGDPRWTGAIDALLDAVDTYVPMPERYVDAPFLLPVENVLTITGRGTVVTGAVERGRVRVGDRVEIFGADTDAAATVVTGLETFGKPMEEAQAGDNVALLLRGVPRDGVRRGDVVAAPASVSPSRRFTAQVYVLSAAEGGRTTPVATGYRPQFYLRTADVVGDIDLGETAVARPGDTVTMTVELGRDMPLEAGLGFAIREGGRTVGAGTVSSVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JKJ1</accession>
    <name>A0A2M9JKJ1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CG723_34615</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000021">
        <property type="protein sequence ID" value="PJN07384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN07384">
        <property type="protein sequence ID" value="PJN07384"/>
        <property type="gene ID" value="CG723_34615"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007995">
        <property type="entry name" value="DUF742"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36221">
        <property type="entry name" value="PTHR36221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05331">
        <property type="entry name" value="DUF742"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PJN07384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="134" mass="14492" checksum="C65C2F5959BBCE38" modified="2018-04-25" version="1">MSPDGEGTQETHHWFDDDAGPVVRPYAMTRGRTTSAAQHRLDLIAVVVAEHRIGDPAADQTLSPEHVDIVGLCRDSPQSVAELAAELDLPIGVVRVLIGDLVDEELVHVTRPVPPAELPDESILRDVINGLRAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JKM6</accession>
    <name>A0A2M9JKM6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MarR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_33560</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000020">
        <property type="protein sequence ID" value="PJN07431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN07431">
        <property type="protein sequence ID" value="PJN07431"/>
        <property type="gene ID" value="CG723_33560"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000835">
        <property type="entry name" value="HTH_MarR-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01047">
        <property type="entry name" value="MarR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00347">
        <property type="entry name" value="HTH_MARR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50995">
        <property type="entry name" value="HTH_MARR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH marR-type" evidence="1">
        <location>
            <begin position="18"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN07431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="154" mass="17445" checksum="B0B08EC2608B08FB" modified="2018-04-25" version="1">MQRAAGRGQHVTDRETAVETIQREMTSFARRARAMAGRMHPELSLVSYTLLSHLDEKGGCRATDLATHYALDKSTVSRQVSALERAGLVMRRVDPDDHRVQVLHPTEAGADILAQVTVSRRQAFQERVADWPEEDLVRFADYLLRYNAQVREDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JLA9</accession>
    <name>A0A2M9JLA9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CG723_32700</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000019">
        <property type="protein sequence ID" value="PJN07659.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN07659">
        <property type="protein sequence ID" value="PJN07659"/>
        <property type="gene ID" value="CG723_32700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015020">
        <property type="entry name" value="DUF1906"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08924">
        <property type="entry name" value="DUF1906"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PJN07659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="226" mass="26004" checksum="BD94F971C027AE28" modified="2018-04-25" version="1">MAPSLDTMRRWRASKYGAVGVYYGGRGRACPHQPRLGHRWMKGVQRLGWRVLPVYVGSQSPCVVERHKKGYRIGRHAWSEGVREGRDAVRRAWAVGIRPGSPLYLDMEAYKYRQKKCARATLAFVRGWDRQVRGKGYVPGFYSSADSGVAHMRAAARAGVRDLPSVIWFARWHARPRLSREPVLWRSAWSRQRRIHQYAGNVKERHGGRTLVIDRNLVHAPVARIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JLN0</accession>
    <name>A0A2M9JLN0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Sphingosine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_32525</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000018">
        <property type="protein sequence ID" value="PJN07791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN07791">
        <property type="protein sequence ID" value="PJN07791"/>
        <property type="gene ID" value="CG723_32525"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003951">
        <property type="term" value="F:NAD+ kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017438">
        <property type="entry name" value="ATP-NAD_kinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005218">
        <property type="entry name" value="Diacylglycerol/lipid_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001206">
        <property type="entry name" value="Diacylglycerol_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016064">
        <property type="entry name" value="NAD/diacylglycerol_kinase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045540">
        <property type="entry name" value="YegS/DAGK_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00781">
        <property type="entry name" value="DAGK_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19279">
        <property type="entry name" value="YegS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00046">
        <property type="entry name" value="DAGKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111331">
        <property type="entry name" value="SSF111331"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00147">
        <property type="entry name" value="TIGR00147"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50146">
        <property type="entry name" value="DAGK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DAGKc" evidence="1">
        <location>
            <begin position="1"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN07791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="296" mass="30518" checksum="EB450E61739737D8" modified="2018-04-25" version="1">MTSEITLFVNPTAGRGRGAQAAQPAASALRAAGFSVRTVVGEDADDALTRARAAVRDGTGALIAVGGDGMANLALQAVAGTRTPLGVIAVGTGNDFARSLGLPVRDPAAAGALMADALKGARIRELDLGRAGGHWFGTVLASGFDSRVNDRGNRMRWPGGRFKYDLAILAELAAFKPIPYRITLDDGPALEVEATLVAVGNGTSYGGGMKICAGADMTDGLFDITVVGDCSRTTLLKVFPRVYRGTHLDHPVVTVHRAKKVELAAEGITGYADGEPLGSLPLTAECVPQAVRVIGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-05-25" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JLQ5</accession>
    <name>A0A2M9JLQ5_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 5">Prokaryotic ubiquitin-like protein Pup</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4 5">Bacterial ubiquitin-like modifier</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">pup</name>
        <name evidence="7" type="ORF">CG723_32600</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CB01635</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Protein modifier that is covalently attached to lysine residues of substrate proteins, thereby targeting them for proteasomal degradation. The tagging system is termed pupylation.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 5">Protein degradation; proteasomal Pup-dependent pathway.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Strongly interacts with the proteasome-associated ATPase ARC through a hydrophobic interface; the interacting region of Pup lies in its C-terminal half. There is one Pup binding site per ARC hexamer ring.</text>
    </comment>
    <comment type="domain">
        <text evidence="5">The N-terminal unstructured half of Pup provides a signal required to initiate unfolding and degradation by the proteasome but is not needed for pupylation, while the C-terminal helical half of Pup interacts with ARC to target proteins to the proteasome.</text>
    </comment>
    <comment type="PTM">
        <text evidence="5">Is modified by deamidation of its C-terminal glutamine to glutamate by the deamidase Dop, a prerequisite to the subsequent pupylation process.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the prokaryotic ubiquitin-like protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000018">
        <property type="protein sequence ID" value="PJN07806.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_016325855.1">
        <property type="nucleotide sequence ID" value="NZ_NNBL01000018.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN07806">
        <property type="protein sequence ID" value="PJN07806"/>
        <property type="gene ID" value="CG723_32600"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00997"/>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070628">
        <property type="term" value="F:proteasome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031386">
        <property type="term" value="F:protein tag"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019941">
        <property type="term" value="P:modification-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010498">
        <property type="term" value="P:proteasomal protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070490">
        <property type="term" value="P:protein pupylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02106">
        <property type="entry name" value="Pup"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008515">
        <property type="entry name" value="Ubiquitin-like_Pup"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05639">
        <property type="entry name" value="Pup"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03687">
        <property type="entry name" value="pupylate_cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="ARC ATPase binding" evidence="5">
        <location>
            <begin position="29"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="15"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="modified residue" description="Deamidated glutamine" evidence="5">
        <location>
            <position position="72"/>
        </location>
    </feature>
    <feature type="cross-link" description="Isoglutamyl lysine isopeptide (Gln-Lys) (interchain with K-? in acceptor proteins)" evidence="5">
        <location>
            <position position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00032321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PJN07806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="72" mass="7975" checksum="1E7F8ECE99843464" modified="2018-04-25" version="1">MATKDTGGGQQKATRSTEEVEEQAQDAQASEDLKERQEKLSDDVDSVLDEIDDVLEENAEDFVRSFVQKGGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JLY5</accession>
    <name>A0A2M9JLY5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Short-chain dehydrogenase/reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_31315</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000017">
        <property type="protein sequence ID" value="PJN07884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN07884">
        <property type="protein sequence ID" value="PJN07884"/>
        <property type="gene ID" value="CG723_31315"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN07884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="281" mass="30518" checksum="42CE1D09C4C395AB" modified="2018-04-25" version="1">MSKVIFVTGAGRGLGTDIAREALESGHQVVATGRRPEEVERTLGGTQDNLLVTKLDVTSLEDAEAAAQAAVDRFGRIDVLINNAGNFYAGYFEEVTPEQMRQQFETNLFGPMNVTRAILPILRRQRDGHIITLSSSAGLIGQEFCAAYAASKFGVEGWMESLRFDIEPYNIRITLVEPGFFRTELLVDASTTWPEPTIADYAERTARTVEAWKGMNGRQGGDPVKLARALLAIADQPQPPLRFVAGADAIEGVEAKARELLAQAQASRELGGNLGHDDVTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JMG5</accession>
    <name>A0A2M9JMG5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Sarcosine oxidase subunit gamma</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CG723_30755</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000016">
        <property type="protein sequence ID" value="PJN08063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08063">
        <property type="protein sequence ID" value="PJN08063"/>
        <property type="gene ID" value="CG723_30755"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007375">
        <property type="entry name" value="SoxG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027266">
        <property type="entry name" value="TrmE/GcvT_dom1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04268">
        <property type="entry name" value="SoxG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PJN08063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="209" mass="22523" checksum="6A296B1DEDA53C14" modified="2018-04-25" version="1">MAEPTNEARTGLSALRVSPLAHLEERMREAAVTGARGVRLTEWPFVSMVNLRVNPASAAAIRVEKTLGAPLPREHGETTSSGAHTAFWLGPDEWLVLSQTEEGVAAAELREALAADPGSVVDVSANRTTLELSGPAARQVLEKGCPLDLHPRVFGPGRAVPTTVGPIAVLLWQVDDAPTYRLLPRSSFADYLARWLIDAMSEYRGPELP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JMJ9</accession>
    <name>A0A2M9JMJ9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Hydroxyquinol 1,2-dioxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CG723_30520</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CB01635</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe(3+)</name>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the intradiol ring-cleavage dioxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000016">
        <property type="protein sequence ID" value="PJN08027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08027">
        <property type="protein sequence ID" value="PJN08027"/>
        <property type="gene ID" value="CG723_30520"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018576">
        <property type="term" value="F:catechol 1,2-dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008199">
        <property type="term" value="F:ferric iron binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009712">
        <property type="term" value="P:catechol-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007535">
        <property type="entry name" value="Catechol_dOase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000627">
        <property type="entry name" value="Intradiol_dOase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015889">
        <property type="entry name" value="Intradiol_dOase_core"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00775">
        <property type="entry name" value="Dioxygenase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04444">
        <property type="entry name" value="Dioxygenase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49482">
        <property type="entry name" value="SSF49482"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00083">
        <property type="entry name" value="INTRADIOL_DIOXYGENAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="INTRADIOL_DIOXYGENAS" evidence="8">
        <location>
            <begin position="159"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS00083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PJN08027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="317" mass="34584" checksum="8B5C8214A42A61CC" modified="2018-04-25" version="1">MSAPQNAAHPAGLPPARPDGRSEKRGALPEQQRQVEAELVETVLASFRDTPDPRLKELMQSLVRHLHGFIREVRLTEAEWQRAVDFLTLAGHITTDRRQEFVLLSDVLGASMQTINVNHDAAGNATEATVVGPFFVDGSPEIPIGGDLAGGAPGEPCWVEGTVTDTDGKPVVGARLDVWEADEDGLYDVQYGPDRTAGRGHLYTDDQGRYAFWGLTPTPYPIPHDGPVGELLEKTGRSPLRASHLHFKATAPGHRAVITHIFVEGDQLLMQDAVFGVKDSLVKGFDRQAPGTPAPDGRTLTDLSWTRVRFDIVLRRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JMN6</accession>
    <name>A0A2M9JMN6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">LysR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_30775</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LysR transcriptional regulatory family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000016">
        <property type="protein sequence ID" value="PJN08067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08067">
        <property type="protein sequence ID" value="PJN08067"/>
        <property type="gene ID" value="CG723_30775"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005119">
        <property type="entry name" value="LysR_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000847">
        <property type="entry name" value="Tscrpt_reg_HTH_LysR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00126">
        <property type="entry name" value="HTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03466">
        <property type="entry name" value="LysR_substrate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00039">
        <property type="entry name" value="HTHLYSR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50931">
        <property type="entry name" value="HTH_LYSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH lysR-type" evidence="2">
        <location>
            <begin position="18"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN08067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="305" mass="34173" checksum="FAE7EEB2895B6F65" modified="2018-04-25" version="1">MHPTPYLYAGRMDGSPDLELRHLRCLVAIVDTGSFTDAAIELGVSQASVSRTLLTLERILGVRLLHRTSRTVAPTTAGVEVLARARHMLAEADELVRQATTGHTRLRIGHAWSAMGRHTAEFQRRWRDRYPDVELHLIRHNTPTGGLAEGLCDLAVIRTAIDTRRYAHALVGHERRYVALASDDPWARRRGIRLSEIRERTLVVDRRTGTTTLDLWPEGARPHVEYIQDVDDWLAAIATGRCVGVTPQSTATQYRRDGIAYRLLRDTEPVPVHLIWPQQSPHPATHAAVALLADLYREDAGSPKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JMR6</accession>
    <name>A0A2M9JMR6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CG723_29615</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000015">
        <property type="protein sequence ID" value="PJN08166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08166">
        <property type="protein sequence ID" value="PJN08166"/>
        <property type="gene ID" value="CG723_29615"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039424">
        <property type="entry name" value="SBP_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000914">
        <property type="entry name" value="SBP_5_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30290">
        <property type="entry name" value="PTHR30290"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00496">
        <property type="entry name" value="SBP_bac_5"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014876960" evidence="2">
        <location>
            <begin position="43"/>
            <end position="806"/>
        </location>
    </feature>
    <feature type="domain" description="SBP_bac_5" evidence="3">
        <location>
            <begin position="129"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="domain" description="SBP_bac_5" evidence="3">
        <location>
            <begin position="358"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="40"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="300"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="455"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="547"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="762"/>
            <end position="806"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="467"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="547"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="778"/>
            <end position="797"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PJN08166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="806" mass="85758" checksum="63E0AE6008A36776" modified="2018-04-25" version="1">MSHDGATSRLARRPARRPVLRSAAFLVSGALAVSALAGCSSGDDEEETSSQAAAQDIAPASRGDVADGGTLRWAVDALPGTLNSYQADADAGTTRVVGAVLPSMFRLDNQGRAVRDPDFLEKAEVIEREPKQVVLYKINQQAVWSDGREIGAADFAAQWRALSGKDSAYWTAHNAGYDRIEKIERGKNNLEVRVTFAKPYADWRSLFSPLYPKDVMGTPDAFNEGSRRELKVTAGPFALKEVDRDAKDVTLVRNPHWWGRQAKLDQMVLRTVPRAERADALVAGKVDLAAVDPEDASRISLAGRDKGSSGPLAHGPGAALTPGESMRSWAVAHGGDEKAADKELDAREKTRAAVAKYEREQSRLDGYVVRKSLEPAFTQLALNGAEGPLADERVRRAVARAIDRKKLAEVVLKPLGLPVHTVGSHLALAGQQAYADSSGALGSQDTNEARALLTDAGWVPGGPLKDEAGKTKPKTAGSESDSDKEGAKDKKGTEDKKGAASEDSDDGTYIGGESDQKPGDRQTPFFAPERTAAYQHAALLHQADAQKLREADKEKKHADQYAKEAAQGGAPGAYAPKGTAAPAGAPAGPLAKDGKPLILRFVLPSGPGSDSLRAVADRISQMLQKIGIRTETSKVADASYFKDHIASGQYDLALYSWPASAFPATDARPIYAKPVPAADGSLTVEQNYTRVGTDHIDQLFDQAIGELDEGEERSLVKQADARIWAAAGSIPLYQRPELVAARRTVVNAGAFGFQEPNYEDIGFLKPGARPGARPNVSGSASPAANPAGKSSEESSEKPSASPSEKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-09-29" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JN31</accession>
    <name>A0A2M9JN31_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_30120</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000015">
        <property type="protein sequence ID" value="PJN08270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08270">
        <property type="protein sequence ID" value="PJN08270"/>
        <property type="gene ID" value="CG723_30120"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006597">
        <property type="entry name" value="Sel1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="SMART" id="SM00671">
        <property type="entry name" value="SEL1"/>
        <property type="match status" value="10"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="12"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="186"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="24"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="488"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN08270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="488" mass="51810" checksum="11A4FF91DB1A11D0" modified="2018-04-25" version="1" fragment="single">MDVMGDKATLLETGRFVQPADREEPGAAAEEARHRPAAESGDVEAMSVLGAMLLRRGDLDGAEPQLRAATAAGDRAAANNLGVLLHQRGYADEAAGWWRIAAVAGSAPAAHALGRHHRERGDEPAAEYWLRQSAEQGHALGAYALADLLEHRSDVGAERWMRAAAEHGHREAAYRLARTLDRRAAHERPEGALRGAPTPADDESGAPGGATATGARRKLPAAAEAEQWYRQAAARGHRRAALHLGAILEKRGELKEAGRWYLNSAKDGEPRAACALGFLLRDAGDEESAGVWWLRAAQEGDGNAANALGALHAQRGETQTAERWYRAAMDAGDINGAYNLGLLCAEQGRTVQADQWYRRAAYAGHREAANALAVLLLQGGDAAGAEPWFSKAAEAGSVDAAFNLGILYAGRDDEVAALQWYERAAAGGHTEAALQAGIARLRDGDERDAERHLRCAAGGGSAEGAYRLATVTPCEGETLCTATADRER</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JN43</accession>
    <name>A0A2M9JN43_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MBL fold metallo-hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_28185</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000014">
        <property type="protein sequence ID" value="PJN08284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08284">
        <property type="protein sequence ID" value="PJN08284"/>
        <property type="gene ID" value="CG723_28185"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041516">
        <property type="entry name" value="LACTB2_WH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17778">
        <property type="entry name" value="BLACT_WH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lactamase_B" evidence="1">
        <location>
            <begin position="39"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN08284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="276" mass="28590" checksum="99F18576406C6F7E" modified="2018-04-25" version="1">MTEAAALPGQPRGGVLSGPATARAVNVLAPNASAMTLDGTNTWIVSEPGSELAVVIDPGPLDDVHLRTVVAVAEAAGKRVALTLLTHGHPDHAEGAGRFAELTRTKVRALDPALRLGDEGLGGGDVVAVGGLEMRVVAAPGHTADSLCFHLPADRAVLTGDTVLGRGTTVVAHPDGRLGDYLDSLRRLRSLTVDDGVDTVLPGHGPVLEDAQGAVEFYLAHRANRLAQVETAVESGYVTASEIVAHVYAGVDRSLWPAAELSVLAQLDYLTEHGLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JN61</accession>
    <name>A0A2M9JN61_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">UPF0182 protein CG723_30110</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CG723_30110</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CB01635</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the UPF0182 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000015">
        <property type="protein sequence ID" value="PJN08257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08257">
        <property type="protein sequence ID" value="PJN08257"/>
        <property type="gene ID" value="CG723_30110"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01600">
        <property type="entry name" value="UPF0182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005372">
        <property type="entry name" value="UPF0182"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39344">
        <property type="entry name" value="PTHR39344"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03699">
        <property type="entry name" value="UPF0182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="22"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="66"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="120"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="176"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="211"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="264"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="294"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="499"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="879"/>
            <end position="899"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="939"/>
            <end position="984"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="939"/>
            <end position="972"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PJN08257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="984" mass="108166" checksum="D1AC10CD0CD7B46E" modified="2018-04-25" version="1">MPDRGGGPTGPRMRVGRPSRRVRSLLMTLGVLAALGMAFVMFAGFWTDWLWYRSVNYSSVFTTTLWTKIGLFFVFGLLMAIAVGLNVWLAHRLRPPLSAMSMEQQSLDRYRMSIAPYKKWLLLGITALVGLIAGASAATQWRTWLMWVNGVPFHQKDPQFHLDVAFYAFDLPWYRFLLGFGFAATILSLIAAALTHYLYGGLRITSPGARATAAATGHLSVLLGVFVTLKAVAYWLDRYGLAVKSSDFKATDNWTGLRYVDANAYLPAKTILFCIAAICAVLFFATLWRRTWQLPVIGFGLMVLSAILIGGLYPAIVQKFQVQPNEQSKEAPYIEKNIEATRKAYGIAGVSPVDYTGKGTVKDSKQQRTDADSAASYRVNDPNVVSPTFQQLEQERKYYQFPKTLDVDRYKGQDTVIGLRELNLAGVEKRNWINDHFTYTHGFGAVAAKGTQTDPDSPGAPLFTESGLPAGGTLGSYQQRIYYGEKTRQYSIVGGPQKELDYEQDDGTQKTTSYSGEGGVSLSNPINRAAYAVSFSEPQILYSGAIGDGSKILYNRTPKERVEAVAPWLTIDGDAYPAVVKGKIQWVVDAYTTSNGYPYASRTTLGDTTADSLNEGDNQRAVVAQQNQVNYIRNSVKATVDAYDGTVKLYTWDDKDPVLKTWKKAFPGTVEPKSAIPQELKDHLRYPQDMFKVQRELLSLYHVTDSDQFYNASDAWQVPNDPTKKDNSAVPPYYLSMKMPGQNDQQFSLTTTFTPSGRPNLRAFMAVDADATSKDYGTIRLLRVTEDKVYGPEQVQNKLNSLSSVANFVRDMKGADSTVLYGNLLTVPLDKGFLYVEPIYAQGRNAEYPLLRKVAVSYGDRTGFADNLGDALNQAFGVDGAQPAEPEKPGGDTTKPPENSTVKEALADAEKAFEEGQAAMKKGDLHAYADAQDKLEDALKRADKAQSAADKAAGDGKGADKSSDKSADQSADKDTSKNSGGSSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JNC6</accession>
    <name>A0A2M9JNC6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CG723_28710</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000014">
        <property type="protein sequence ID" value="PJN08368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08368">
        <property type="protein sequence ID" value="PJN08368"/>
        <property type="gene ID" value="CG723_28710"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024486">
        <property type="entry name" value="DUF2617"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10936">
        <property type="entry name" value="DUF2617"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PJN08368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="173" mass="18653" checksum="ABFD9DDDAFBB24D0" modified="2018-04-25" version="1">MLTTLNTAYTDTRADDLAWALGREPLPALATLDLELAGAQLQLRLLGASHQVLLEEERGTCSETVACIPGSSTPLPLGVAKRMGDWEYEFAAHVETLSKGSFAGRAQELIALVSDHPNGLAGVFPGSPHAFTALLAHRQEGQVHWRTWHAYPQEGQLVVTRTRVGVRIPAAVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-09-29" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JND1</accession>
    <name>A0A2M9JND1_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">NB-ARC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_28735</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000014">
        <property type="protein sequence ID" value="PJN08373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08373">
        <property type="protein sequence ID" value="PJN08373"/>
        <property type="gene ID" value="CG723_28735"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043531">
        <property type="term" value="F:ADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002182">
        <property type="entry name" value="NB-ARC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00931">
        <property type="entry name" value="NB-ARC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NB-ARC" evidence="2">
        <location>
            <begin position="613"/>
            <end position="770"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="51"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="532"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="67"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="88"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN08373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="1416" mass="155001" checksum="D4AA1943F0C6C7FF" modified="2018-04-25" version="1">MNRSPSHGGVAGDGIGPGAASLAEASPQPHWYEAGEVLWLAAQRWLRLKDARRGRPQPGAPPELPEAPEEGHPRPEDVDAPVPELTEQPVEQPAPPPGPSAPAPDPGDHVDSLLMSLGNGFALDRSREIEKALNPLKRRIASRSQVFLNEEATAELHAETGMWLPQLEPGQERWLTVTLLVDSGDSMRLWSHTAQRLAETLHCSGAFRDVRTVRWQQDGAGSEVAGDTDGRHLVLVLTDLHADHWGDGSARRRLARWARTMPVAIVHVLPEHVWARAGTQTSSLRLTSPRPASPNSAWTDEPVGLVLPTAEADGPDGFDGVRLPVVTLTPEGLGGLARFLAHDSSGGYTVRVLDRTPGDETAVARRPAAALPADVQVKTVRAQLSPTAYHLARLSAAVPLNLDVLRLLQEGLIPGARNWHVAELLLSGLLRRTEAEPGEAAGPGVELEFDDGVRRELLSDGTRGETARALMLALDHLAVAVPAYGEGVALLREPDRARSVSMEGLRPWISSILPAFAAMAGPHATAARELEARLDEPPPRVTTTSGEHSRLGGGAEPTAPEDTGNEERVEVVSGLQSTQAGARGDALQKPPPVWGNVPPRNRAFTGRVQLLDDLHRRLQEGTTAVLPEALQGMGGVGKSQLAVEYVYRHLHEYQIVWWIPAEQPQQIRQFLVQLAGRLGLNVGSGEANTAVPAVIEALRVGEPFKNWLLIFDNAEDPESVREFFPTNGPGRILVTSRNSQWASSARPLEVDVFTREESRSLLQMRAPSLDNATADRLAETLGDLPLGIEQAAVWLAETGMPADEYLRMFEQQANELMVSEPPVDYPLSVAAAWNVSLDRLRKHHPAALQLLQMCAFFAPEPISRRLLTGVRDAPVPPELSAALSDPIRLSRAIREINRYALARINHETNTIQLHRLVQRVLINQMTEPLKSQMRAGAHRLLAKDDAGEPDKSHRWQQYGDLLPHVLNSRAVESTDPWVRNLVLNEILYMYYWGDHQGSLDLARETYTTWREADGDTAEHVLNAARIYTNSLRILGRYSEAYELDQRTLAGMTQVLGPEHESTIDITSMLAWDLRLRGDFQAALDLDKHAFETCERLFGPNDPSTLLSAHRHALNLRFIGHFRAALALDRMTHGRKVAELGENAVSTLSTLAAVTFDLQEGGEYLAARDQARDVEERFRNTVGDSHPNTISAMRVLSVAERRAGQHALALELSGRALVMFRTRYGDLYPQTVNALASHAIDVRHSGDLARALELGQEGYEGYEALLGARHPHSVAAHVNHAICLRLAGRTEEARASDVDSQEKLIELIGEDHPNTLSCTANLAADLFELGEMQASADIATRGLDLCRTHLGEDHPITLATALNLSLGLRQLRRDDEADELYADTAERYGRTLGEDHPATVAAADGRPANCDIDPLLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JNG6</accession>
    <name>A0A2M9JNG6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CG723_28945</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CB01635</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000014">
        <property type="protein sequence ID" value="PJN08408.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08408">
        <property type="protein sequence ID" value="PJN08408"/>
        <property type="gene ID" value="CG723_28945"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="36"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="75"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="105"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="135"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="167"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="192"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="227"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="257"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="295"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="330"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="359"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="383"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="426"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="464"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="7">
        <location>
            <begin position="38"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PJN08408.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="490" mass="49037" checksum="A69B4BB793017863" modified="2018-04-25" version="1">MAVTESPPPTETDVLAPPPPVADVGPADSSFSTRGLLVLITLCCATFMCGLDFSIVTVALPDIGGSLGFSSPGTLQWVATASLLPSASLLPLFARVADLVGRKKLFTFGVALFTLFSLGAALANSPGVLIATRAGQGTAAAMIAPAAIALMTGYFPEGPQRARALGLNGAVMSLGFVLGALGGGVITSDFSWRWTMVVLCVMGAVALAGALALPVMRESAAAKRMDIPGAVLATLGLFGLVFGISNGGDKGWVRADSLGSVVGGLVLLGAFLVVERRHPEPLIPLGVLGRPTIKWSGLFGVVTFGMCAGTTVLLSLYMQDVLGFTPLQAGLSYLGEGAAAMLGGMYVSKLLGRFGGGRVLTAGLLIQGAGTVAMFSLPQSGSIAPLIITSSVMGLGHVFSVVSFITVMTTGVSEEDQGVVGGLSQLPQYVAAIGVAGLSAIAAARTHVLSGGAGSDAGATLGGLHAGMVTAGVIALVGGGLAAAVLRRRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JNR2</accession>
    <name>A0A2M9JNR2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Aminoglycoside phosphotransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_29200</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000014">
        <property type="protein sequence ID" value="PJN08504.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08504">
        <property type="protein sequence ID" value="PJN08504"/>
        <property type="gene ID" value="CG723_29200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="APH" evidence="1">
        <location>
            <begin position="31"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN08504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="339" mass="37389" checksum="600D2AF2BC004DCB" modified="2018-04-25" version="1">MWRVPRSSAHPAPPLRALLRQYDAGSPLACEPVDQGLLNRGYRLATTRGRYFLKHHFDPETADPAAIARQHRATERLAALGVPVAPPLPASDGRTVTVIGGASYALHPWVEGRHRSGAQLTAAQCRTLGALLGLVHACLEKVMGAAPARGRASADPADTLALIDTLLERVRSRRPHDAFDELARHRLVERRALLESCAGRRPPQASATGWVHGDFHPFNLLYQGGVPAAIVDWDRLGVQPRAEEAVRAAVIFFVRPAGTLDLPKVRAYARAYRRASGAGADELAAAVHRVWWERLNDFWILRWRYERGDTRADPQFPAASALAVWWTKEYGAVRNAFAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JNZ9</accession>
    <name>A0A2M9JNZ9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_27915</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000013">
        <property type="protein sequence ID" value="PJN08590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08590">
        <property type="protein sequence ID" value="PJN08590"/>
        <property type="gene ID" value="CG723_27915"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011049">
        <property type="entry name" value="Serralysin-like_metalloprot_C"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51120">
        <property type="entry name" value="SSF51120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014993649" evidence="1">
        <location>
            <begin position="29"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN08590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="142" mass="13488" checksum="0ED8F1DBC2CCB5BF" modified="2018-04-25" version="1">MIRHVMRTLCAATLVAAPLALTATPAQALTSCTVNGRPVSGTTVSGTAGSDNISCGALASGDSVNGLGGSDYIVINGIVAGTVDGGAGGDFLMANAGTTATGKILGGADGDSLFVGPNAGTVDGGLGSDFCRVASGNPPISC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JP19</accession>
    <name>A0A2M9JP19_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CG723_27440</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CB01635</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000013">
        <property type="protein sequence ID" value="PJN08618.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08618">
        <property type="protein sequence ID" value="PJN08618"/>
        <property type="gene ID" value="CG723_27440"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045621">
        <property type="entry name" value="BPD_transp_1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19300">
        <property type="entry name" value="BPD_transp_1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014728353" evidence="6">
        <location>
            <begin position="25"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="96"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="131"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="177"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="282"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="7">
        <location>
            <begin position="92"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PJN08618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="312" mass="31463" checksum="A0EA820ACE49942A" modified="2018-04-25" version="1">MAARRLGGALATLLVGSFVLFAAAEVLPGDAAAAALGGSATPADVARMHAELGLDRPVLVRYGDWIGAAFSGDLGHSLVDRRPVVEIISGPLADTLLLAGVCALLTVVLALAVGIAAGLRPGGLLDRLLSGGAVTLVSVPQFVTAGILTLVFSSWLGVLPAVSLVPFGEPLLAHPEALVLPVAALTLFSASWASRMVRAAVVDAAAAPHVEAARLAGLSPARVVLRHLLPTAAGPCAQVFGWLAGTLVGGTAVVEKVFNYPGLSRELVAAVQHHDAAVLEGIGLLMAAAVVGGLLLADLLAMAVDPRMRTAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-05-25" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JPD9</accession>
    <name>A0A2M9JPD9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Zn-dependent alcohol dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CG723_26530</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CB01635</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000012">
        <property type="protein sequence ID" value="PJN08657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08657">
        <property type="protein sequence ID" value="PJN08657"/>
        <property type="gene ID" value="CG723_26530"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="PKS_ER"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="PKS_ER" evidence="3">
        <location>
            <begin position="3"/>
            <end position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PJN08657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="349" mass="36226" checksum="4CD585731DC44BD2" modified="2018-04-25" version="1">MRGVVFDGVRADVVDDLEIRDPGPGEVLVDVAAAGLCHSDLSVIDGTIPFPAPVVLGHEGAGVVEAVGAGVTHVAPGDHVALSTLANCGACADCDRGRPTMCRKAIGMPTQPFSRGGTPLYQFAANSSFAERTVVKAVQAVPIPADIPLTSAALMGCGVLTGVGAVLNRARVDQGDTVVVIGTGGIGLNVLQGARIAGASRIVAVDANPDKEAVARQFGATDFLTSAAGVRDVLPHGADHVFECVGRVELVRQAVDLLDRHGQAVLLGMPGADAEASFVVASLFLDKSILGCRYGSSRPQRDIRLYADLYRQGRLLLDELVTETYPVEDFAKAAQDAQQGRVARGVLVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JPF5</accession>
    <name>A0A2M9JPF5_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Tricorn protease homolog</fullName>
            <ecNumber evidence="7">3.4.21.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CG723_27115</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">CB01635</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Degrades oligopeptides.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the peptidase S41B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.-" evidence="7"/>
    <dbReference type="EMBL" id="NNBL01000012">
        <property type="protein sequence ID" value="PJN08754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08754">
        <property type="protein sequence ID" value="PJN08754"/>
        <property type="gene ID" value="CG723_27115"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008236">
        <property type="term" value="F:serine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011659">
        <property type="entry name" value="PD40"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005151">
        <property type="entry name" value="Tail-specific_protease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028204">
        <property type="entry name" value="Tricorn_C1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029414">
        <property type="entry name" value="Tricorn_PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012393">
        <property type="entry name" value="Tricorn_protease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43253">
        <property type="entry name" value="PTHR43253"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07676">
        <property type="entry name" value="PD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03572">
        <property type="entry name" value="Peptidase_S41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14684">
        <property type="entry name" value="Tricorn_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14685">
        <property type="entry name" value="Tricorn_PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036421">
        <property type="entry name" value="Tricorn_protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00245">
        <property type="entry name" value="TSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="SSF50156"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 7" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 7" id="KW-0720">Serine protease</keyword>
    <feature type="domain" description="TSPc" evidence="11">
        <location>
            <begin position="847"/>
            <end position="1039"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="535"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1070"/>
            <end position="1089"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="8">
        <location>
            <position position="747"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="8">
        <location>
            <position position="970"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="8">
        <location>
            <position position="1028"/>
        </location>
    </feature>
    <feature type="site" description="Transition state stabilizer; via amide nitrogen" evidence="9">
        <location>
            <position position="971"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR036421"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR036421-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR036421-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PJN08754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="1089" mass="119003" checksum="5464DB3885CFC38C" modified="2018-04-25" version="1">MSDNAYLRFPHLHEDRLCFETEDDLWVAPLDRPGRAWRVTVDRTKVSSPRFSPDGRHIAYTTWRSLDPEIHLAPVDGGPARRLTYWGSTDTQVRGWTPPDKDGRTVILAVASHSQPFSYFTWAYDVPTDGSPGGRLPWGPVSDIAVAEIDGERKTLLLTGTPPHEPAAWKRYRGGAQGRLWLHGEQLVADLDGHLEAPMFVAGRIAFLSDHQGIGNVYSCLPDGSDLRRHSDHDAFYARNASSDGTRIVYQCAGDLWIIDDLSAGSVPRKLEVRLGGPRVGRRPYQVPAAHHVDGLSVDETGRASAVVVRGSLYWLTHRDGPARTIADTPGVRVRQPEMLGSGGQVAYVTDAEGEDAIEISYLPRASGEREPRRLASGELGRVLEMVGDPDGERLAIASNDGRLLLIDTAEEEEEGGGEQTGDGVIELIRSINGPVRDLAFSPDGAWLTWSHPGIGRSLRQIKMARIKDRTIVDVTNGRFEDENPVFTRDGRYLAFLSWRGFDPVYDVHTGDLSFPLGCRPYLVPLSSATPSPFALSPHGRTAAGGLDPTEDSGADGTPSVEIEGLANRVVPFPVSASKYSALYPVSGGGLVWLRWPISGALGETFVNPADTSGRPTLEYFNLSKGKKTELVTHLDWFAVSGDGTRLVVVDEGDLRAVPSTEAGDSDTTVWIDLRRILHEVDPAAEWRQAYDEAGRIIRAYYWEPKMCHVDWDAVLDQYRPLVERVASPDEFADLLREVLGELCTSHAYVAAARRNEGPPHYQRAQGLLGANFVHRDEGWQLVRILPGDSSDSKARSPLAGSGIREGAVLTHVDGRPVDPVTGPFPLLAGSGGTTVELTFRPAEGDGRPRRVAVVPLIDERPLRYQDWVAKRRAVVRELSGGHCGYLHIPDMGGSGWAQFNRDVRMEVSRPALIVDVRGNAGGHISELVIEKLTRKILGWDLTRNAQPVSYASNAPRGPVVALADEATSSDGDMITAAFKLLGLGPVVGQRTWGGVVGMTGRHTLGDGTVITVPMNAAWFPEYGWSIENKGVEPDFEVLRTPLDWAEGRHAQLDDAVYLALDLLVAGPAKTPPDYTNTPNHARPELPPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JPV8</accession>
    <name>A0A2M9JPV8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">ATP-dependent DNA ligase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CG723_25840</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000011">
        <property type="protein sequence ID" value="PJN08911.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08911">
        <property type="protein sequence ID" value="PJN08911"/>
        <property type="gene ID" value="CG723_25840"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04863">
        <property type="entry name" value="MtLigD_Pol_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014145">
        <property type="entry name" value="LigD_pol_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033649">
        <property type="entry name" value="MtLigD_Pol-like"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02778">
        <property type="entry name" value="ligD_pol"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0436">Ligase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PJN08911.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="294" mass="32327" checksum="A107E88732040FE6" modified="2018-04-25" version="1">MTPITEVEGRRLALSNLDKVLYPATGFTKGELLHYYATVAGALLAHLYDRPVSFLRYPDGPEGQRFFTKNVPPGTPAWVRTADVPHSRSAPSRQVLVQDLASLMWAANLVTEFHTPQWQADAPGQADRLILDLDPGEPADVVECCAVALWLRERLRADGLHSYVKTSGSKGLHMLVPLEPTPSDRVSAYAKTLAVEAEAEHPELVVHRMTRSLRPGKVFVDFSQNAAAKTTATPYTLRARPEPTVSAPVTWEEVEACTDARDLTFLADDIAPRLETYGDLLGPLINLNRAGRVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JPW3</accession>
    <name>A0A2M9JPW3_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">NlpC/P60 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CG723_25915</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CB01635</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C40 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000011">
        <property type="protein sequence ID" value="PJN08923.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08923">
        <property type="protein sequence ID" value="PJN08923"/>
        <property type="gene ID" value="CG723_25915"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000064">
        <property type="entry name" value="NLP_P60_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00877">
        <property type="entry name" value="NLPC_P60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="SSF54001"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51935">
        <property type="entry name" value="NLPC_P60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014611692" description="NlpC/P60 domain-containing protein" evidence="4">
        <location>
            <begin position="27"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="domain" description="NlpC/P60" evidence="5">
        <location>
            <begin position="234"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="349"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="43"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PJN08923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="383" mass="40606" checksum="EC4BBB185EE18956" modified="2018-04-25" version="1">MSGSLLRWACAAAVASTLAAPGPASAAPTPDPQPLPAANRNAVATLLTDLQRLYQEAEKATEKYNATAEKLKKRRKTAGDLARKLATARTSLHESRGAAGRLAREQYQGSSNLSPYLRLLLARDPQHALDQGHVIRRVAQERMATVDRLVGGEKRADSLATQARKALAEQTRLSERQKKDRDAVQARLKDVERLLASLGPGQLAELTRLEDAGMAKAQKTFMASGALSSQQAPSRAGDAAVAYAVKQIGKPYVWGAEGPASFDCSGLTSQAWEHAGEVIPRTSQEQWAKLPRVPLNKLRPGDLVVYFREATHVAMYLGDGMVVQAPRPGAKVKVSPIAANPLLGAVRPDQGDVSMKGYTPPKLPGGATGGDDTGYGAAGAPTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JPZ4</accession>
    <name>A0A2M9JPZ4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CG723_26055</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000011">
        <property type="protein sequence ID" value="PJN08949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08949">
        <property type="protein sequence ID" value="PJN08949"/>
        <property type="gene ID" value="CG723_26055"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PJN08949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="277" mass="30946" checksum="19D68F41188F722D" modified="2018-04-25" version="1">MDHSRARILYVTDLAYPARGRRYCDEDITLSARLREEFDVALCHPLDAAALMDGFDAVVVRNSGPVLHYQAAYDAFRERALARGVRVYNALSGKADMAGKGYLLDLTAAGYPVIPTVARAADLHLLPEADEYVVKPLLGADSIGLEFVGREALPGLEFDGILVQPRIRFRYEVSFYFVDRALQYALYAPRPDERWVLEPYEPTDADREFAQKFVDWNTVGHGIQRVDACRTPEGELLLVELEDLNPYLSLDLVDASTRDAFVAAMADSLRGLLADEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JQ07</accession>
    <name>A0A2M9JQ07_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CG723_25925</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CB01635</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GPN-loop GTPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000011">
        <property type="protein sequence ID" value="PJN08925.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08925">
        <property type="protein sequence ID" value="PJN08925"/>
        <property type="gene ID" value="CG723_25925"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004130">
        <property type="entry name" value="Gpn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03029">
        <property type="entry name" value="ATP_bind_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PJN08925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="227" mass="24501" checksum="98B40D805870FD5C" modified="2018-04-25" version="1">MDSVVSEGVTEGVTPAFVPAQPSSGREAIAFEPQEELQAWQTDRTRAPIATKIVVAGGFGVGKTTLVTAVSEIQPLQTEALMTQASEETDDLTATPDKTTTTVAMDFGRITLDDDLVLYLFGTPGQQRFWFMWDDLVRGAIGAVVLADTRRLSDCFPALDYFESCGLPYVVAVNHFDGSDEFAAADVREALTVPPHIPVLIMDARQRISVVETLLALVGHALDATPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JQ50</accession>
    <name>A0A2M9JQ50_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ABC transporter substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_26330</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000011">
        <property type="protein sequence ID" value="PJN09001.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN09001">
        <property type="protein sequence ID" value="PJN09001"/>
        <property type="gene ID" value="CG723_26330"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042597">
        <property type="term" value="C:periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030678">
        <property type="entry name" value="Peptide/Ni-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039424">
        <property type="entry name" value="SBP_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000914">
        <property type="entry name" value="SBP_5_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30290">
        <property type="entry name" value="PTHR30290"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00496">
        <property type="entry name" value="SBP_bac_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002741">
        <property type="entry name" value="MppA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014993650" evidence="1">
        <location>
            <begin position="26"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="domain" description="SBP_bac_5" evidence="2">
        <location>
            <begin position="104"/>
            <end position="458"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN09001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="561" mass="61655" checksum="AEAA76DFE37212D9" modified="2018-04-25" version="1">MRRSTVTAVAAALSATLVLAGCGSSDDGKPVRKEAAPAVDGQDINAHPVSDLRQGGTLKMGLSTWPANFNWNTPDGYQGDATEVDAALLPDLFDNDAKGAQHVNPNFLVSAKVVSTDPQVVEYELNPKAKWSDGKPLSWKDFAAQWKALNNTDKDYEAAVTDGYEQISKVEQGKDAHGVRITFDKPYAEWQNLFDPVYPAAYIDTPEKFNKGWTQKLPVTANAFKIKNIDRTAQTITIVPDPAWWGPKPKLDSVVYRIVDFTATTEAYLNKEIDSATALLPEDYKRLVKSAGTDIRRGARWDEVHIALNGAHGPLKDVRVRQALGNAIDRKGINAAFSKDLSFELKPLDNHLFMPNQEGYQNNSGEYGKYDPERADKLLDEAGWKSAGEGKTRTKGGKDLTLEYTLSAGSSSAQVDQAELVQQQLAAVGIKVTLKKVPANDYFTKFVNTGNFDLTSFRNVDAVFKNIVIPTFVQPQGGNLFQNYGSIGSPKIDALLKKAQQTTDTTEANKLYNEADKELWKLGHSIELYQRPQIVAVRSSLANFGAEGLASSDYTKIGWLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JQF9</accession>
    <name>A0A2M9JQF9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Aldehyde dehydrogenase PuuC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CG723_24665</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000010">
        <property type="protein sequence ID" value="PJN09112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN09112">
        <property type="protein sequence ID" value="PJN09112"/>
        <property type="gene ID" value="CG723_24665"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016620">
        <property type="term" value="F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016160">
        <property type="entry name" value="Ald_DH_CS_CYS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="SSF53720"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00070">
        <property type="entry name" value="ALDEHYDE_DEHYDR_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldedh" evidence="3">
        <location>
            <begin position="26"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PJN09112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="487" mass="51446" checksum="D2B5579D849787FD" modified="2018-04-25" version="1">MNTYADWQRRAAELTPRTRAFINGTWTESHTRATFPTTNPATGKVTAHVTRGEAPEIDAAVRAARASFDDGRWSRTDPAARKRVLLRLADLITANAEELALLDTLDMGKPIAESYGTDVPGAAGVFAWYAEAADKLYDEIAPTPPGHLATVRRTPLGVVGAVVPWNFPLDLASWKLAPALAAGNSVVLKPAEQSPLSALRLAELAAEAGLPDGVLNVVPGMGGTAGRALGLHKDVDTLVFTGSTEVARLFLSYSAESNMKQVWPEAGGKSPNVVFADADLDAAAERAAWGFAYNAGQVCSANTRLLVESSIADDFTARVAEHAARFVPGDPLDPGTNLGPLVDEAQATRVLAAVEASDGKVITGGTRDGAYLTPTIVTGLHPDAPLAREELFGPVLTVHAFTAEEEAIRTANDSPYGLAASLWTRDLARAHRVSDALHAGTVSVNTVDALSPLTPFGGFKQSGHGRDLSLHSLDKYTGLKTTWITYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-06-02" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JQU9</accession>
    <name>A0A2M9JQU9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ABC transporter substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_24470</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000010">
        <property type="protein sequence ID" value="PJN09235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN09235">
        <property type="protein sequence ID" value="PJN09235"/>
        <property type="gene ID" value="CG723_24470"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN09235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="192" mass="21616" checksum="C44B0D5154BF8D0C" modified="2018-04-25" version="1">MSLTHASRITGTNRLSTARPPKQRVAGPDLPEPPGHDLSALRLPELRTLRRDAQQDEADLSYVRRLLQGRIDILRAEVARRRDPEAPVVDRLSEILTDKAAGHRSSARHVTLGTPRSEEYRGLAAEMLAEVELSDLDARTDDELHTAMGRLVRYEQQVSRRRHLLQSTADDCSAEIARRYREGEAQVDDLLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JR18</accession>
    <name>A0A2M9JR18_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_23465</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000009">
        <property type="protein sequence ID" value="PJN09308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN09308">
        <property type="protein sequence ID" value="PJN09308"/>
        <property type="gene ID" value="CG723_23465"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="99"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN09308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="124" mass="12428" checksum="2EEAABF124DD03D6" modified="2018-04-25" version="1">MVCSVAARVHGCYPVRVMVSMRPMARSASAWERGKAAQVSVVCCGEAPAGQRAFVDQQFYVGGDGDPGVGLPGEQVGGAQAHQLGAVRAQRNTVAWGSSNSDGALARSPAGTLGGCAAAPSPAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-05-25" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JRF1</accession>
    <name>A0A2M9JRF1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">LacI family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CG723_23445</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000009">
        <property type="protein sequence ID" value="PJN09422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN09422">
        <property type="protein sequence ID" value="PJN09422"/>
        <property type="gene ID" value="CG723_23445"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01392">
        <property type="entry name" value="HTH_LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000843">
        <property type="entry name" value="HTH_LacI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046335">
        <property type="entry name" value="LacI/GalR-like_sensor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00356">
        <property type="entry name" value="LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13377">
        <property type="entry name" value="Peripla_BP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00354">
        <property type="entry name" value="HTH_LACI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50932">
        <property type="entry name" value="HTH_LACI_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH lacI-type" evidence="4">
        <location>
            <begin position="2"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PJN09422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="343" mass="35987" checksum="BA971E66A980CDDF" modified="2018-04-25" version="1" fragment="single">MVAITDVARQAGVAVSTVSYVISGKRPISAPTRRKVLDAMNRLGYRPPSSARSRTIGLAVRVDDGAHRPLLAEFMLTASVAARRHACNVLLLTDHEEHGVLDAALLDGLILMDIGIVDPRLDVIRALPVPTVLIGLPREPAGLACVDLDFRAAGALCVDHLADLGHREVVLLGAPEAAYARHAGFAVRTVAGAAERSAARGVRLTHRTVAGDWDSVAGTLARVLAERPRTTALIVQNEAATPHLAPLLRGMGRAVPEDLSVVALGSDVVATAGTPALTSVAVPAAALTERAVDLLVARLDGATAPGRRPVLLEPRLSVRASTTAPPAATVWWTTVNATEPRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JRG5</accession>
    <name>A0A2M9JRG5_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF1990 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_22040</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000008">
        <property type="protein sequence ID" value="PJN09459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN09459">
        <property type="protein sequence ID" value="PJN09459"/>
        <property type="gene ID" value="CG723_22040"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018960">
        <property type="entry name" value="DUF1990"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09348">
        <property type="entry name" value="DUF1990"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF1990" evidence="1">
        <location>
            <begin position="99"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF09348"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN09459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="218" mass="23841" checksum="F20BF902E8FB8100" modified="2018-04-25" version="1">MGVLLVSWEYMWRVTALHRTEGSGDAGDLPPPLPAAHVDEFTKPLADGVGPMFHRRFSVRIEGAAMGPEELIDAVAADLNGPAPSTVAVFHRTRGKQGSPARPGDEYRVQMPGPWDGPVRVLDRDALSIRLGTLRGHLEAGQIQFWAGADDDVLEFGVEAWSRAGDRWADVFYSRLRVAKEIQFNMWVHFCLGAAGMAGGRPRGGVTIDTRRVSLDLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JRV6</accession>
    <name>A0A2M9JRV6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">GntR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CG723_22890</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000008">
        <property type="protein sequence ID" value="PJN09584.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN09584">
        <property type="protein sequence ID" value="PJN09584"/>
        <property type="gene ID" value="CG723_22890"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07377">
        <property type="entry name" value="WHTH_GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.530">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011711">
        <property type="entry name" value="GntR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008920">
        <property type="entry name" value="TF_FadR/GntR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07729">
        <property type="entry name" value="FCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
        <property type="entry name" value="GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00035">
        <property type="entry name" value="HTHGNTR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00895">
        <property type="entry name" value="FCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00345">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48008">
        <property type="entry name" value="SSF48008"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50949">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH gntR-type" evidence="4">
        <location>
            <begin position="9"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PJN09584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="253" mass="27163" checksum="9CC67461D7D2947E" modified="2018-04-25" version="1">MFTKVDGPVRLADRVAAMLADEIESGRLTTGDKLPTEVELVKQLGVSRTVIREAVSRLANAGLVEPRQGRGVFVLPRRTRPLDLEADTTSTTDTKAKVLQIVEVRRAMEGEAAELAATRATAADHARMRKALDAIDAAVSAGGDGADEDLAFHRSIAESTGNAVLVSTVRYLGEVSRSGIRVTRANEARRGDFFDAVRDEHHAILAAIEQGNAEAARTAARRHLEHAAARLQKAGPEFWNTAQDLGVELDAAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JSE1</accession>
    <name>A0A2M9JSE1_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ribosome maturation factor RimP</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">rimP</name>
        <name evidence="6" type="ORF">CG723_21635</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CB01635</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Required for maturation of 30S ribosomal subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RimP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000007">
        <property type="protein sequence ID" value="PJN09799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN09799">
        <property type="protein sequence ID" value="PJN09799"/>
        <property type="gene ID" value="CG723_21635"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042274">
        <property type="term" value="P:ribosomal small subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01734">
        <property type="entry name" value="YlxS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01077">
        <property type="entry name" value="RimP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003728">
        <property type="entry name" value="Ribosome_maturation_RimP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028998">
        <property type="entry name" value="RimP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036847">
        <property type="entry name" value="RimP_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028989">
        <property type="entry name" value="RimP_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035956">
        <property type="entry name" value="RimP_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33867">
        <property type="entry name" value="PTHR33867"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02576">
        <property type="entry name" value="DUF150"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17384">
        <property type="entry name" value="DUF150_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74942">
        <property type="entry name" value="SSF74942"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75420">
        <property type="entry name" value="SSF75420"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="domain" description="DUF150" evidence="4">
        <location>
            <begin position="12"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="domain" description="DUF150_C" evidence="5">
        <location>
            <begin position="88"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF17384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PJN09799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="170" mass="18817" checksum="DC1A7B652AE74D68" modified="2018-04-25" version="1">MSTTQSERLRSLLEPLVSSQGLDLEEIEVASVGRKRVLRVVVDSDSGADLDQVADVSRALSAKLDETDAMGEGEYDLEVGTPGAERPLTEHRHYMRAVDRLVKFQLADGADTELVARILKVDDEGLDLEVPGVKGRKPTARRLTFDDIAKARVQVEFNRKNKNEENAEEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JSE5</accession>
    <name>A0A2M9JSE5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ABC transporter substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_21700</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000007">
        <property type="protein sequence ID" value="PJN09811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN09811">
        <property type="protein sequence ID" value="PJN09811"/>
        <property type="gene ID" value="CG723_21700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042597">
        <property type="term" value="C:periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030678">
        <property type="entry name" value="Peptide/Ni-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039424">
        <property type="entry name" value="SBP_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000914">
        <property type="entry name" value="SBP_5_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30290">
        <property type="entry name" value="PTHR30290"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00496">
        <property type="entry name" value="SBP_bac_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002741">
        <property type="entry name" value="MppA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="601"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="domain" description="SBP_bac_5" evidence="2">
        <location>
            <begin position="108"/>
            <end position="480"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN09811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="632" mass="69217" checksum="395DA890298618B3" modified="2018-04-25" version="1">MDTKDQPKRAHAPLFSRSPRRAPRRTLRVLLAAGAAAFTLTAGLATPLNPAPQEAKAADGGKKVLTVALAQSVDSLSPFLAQRLVSTSIHRMMYEYLVNYDPKDNHAVPGFATDWKPSADKLTWTYTIRSDSKWSDGKQATAADAAFTFNKMMTDEGAATANGSFVSNFEKVTAPSATQLVIELKKPQATMAALDVPIVPEHIWKNVKDFSKFNNDKTFPVVGNGPFVLTDYKVDQYVKLKANKDFWRGAPKFDEVVFKTYKDQDAAVAALRKGEVSFVAGSPALTPAQAASLKGEQNIKVNEGPGRRFFALATNPGAQTKDRKKFGNGNKALLDQKVRQALFLSIDRKAIVDKVFQGHAVEGEGYIPPRFGDYFWKPSASQALGYDPDKAGKLLDEAGYKMKGSERVGKDGKPLNFRILCHATDPNDKAIGKYLKEWWGKLGIGLKVDCLDDVSVPWYAGEYDLAFDGWSVNPDPDFVLGIHTCAALPVKAKESAQTDNFICDKTYDDLYKKQLAEYDPAKRADIVKQMESWLYDSGYMNVIAYPNAVEAYRTDQIKSIQTMPTEAGNIYGQDGYWSWWSAVPAGATTDSGGKSSSSSTGVIIGIVAAVVILGGGGLFLTKRRRTSADDRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JSL9</accession>
    <name>A0A2M9JSL9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">SigE family RNA polymerase sigma factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CG723_19240</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CB01635</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000006">
        <property type="protein sequence ID" value="PJN09879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN09879">
        <property type="protein sequence ID" value="PJN09879"/>
        <property type="gene ID" value="CG723_19240"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050896">
        <property type="term" value="P:response to stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039425">
        <property type="entry name" value="RNA_pol_sigma-70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014325">
        <property type="entry name" value="RNA_pol_sigma-E_actinobac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013249">
        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43133">
        <property type="entry name" value="PTHR43133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08281">
        <property type="entry name" value="Sigma70_r4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02983">
        <property type="entry name" value="SigE-fam_strep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="5">
        <location>
            <begin position="95"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4_2" evidence="6">
        <location>
            <begin position="185"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PJN09879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="257" mass="28408" checksum="685E231FAA8FEBB2" modified="2018-04-25" version="1">MNTLHSTTTGAVVTRLHDALVRSPGSGKHELSGAVSGRGCARGTGRQHTAYMTVVDANQAASDGGAAYGEESGERKKSLSEAADAEAAFTAYVQERRASLYATAYHLTGDRFEAEDLLQSALFSTYRAWDRISDKAAVGGYLRRTMTNLHISAWRRRKLNEYPTEELPETAGDTDAMRGTELRAVLWQALARLPELQRTMLVLRYYEGRTDPEIADILDISVGTVKSSIWRSLRRLREDEALSFGRDLEESFGELVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JSV3</accession>
    <name>A0A2M9JSV3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Glycine/betaine ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CG723_19705</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CB01635</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000006">
        <property type="protein sequence ID" value="PJN09955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN09955">
        <property type="protein sequence ID" value="PJN09955"/>
        <property type="gene ID" value="CG723_19705"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="25"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="99"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="127"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="151"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="195"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="273"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="299"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="347"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="425"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="448"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="476"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="585"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="625"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="147"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="467"/>
            <end position="646"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PJN09955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="657" mass="68132" checksum="62BD3F1F646FE23C" modified="2018-04-25" version="1">MAAASTATAPAADTPRFGALLRNRALGKLLLLAVVAAVLVPIVNAKWASGSWPHALTVDLTEPLGKTSDWIIDNRDSHPLFLYFFGHISNAVVLSVRGAYLVLLAAGWAGVTAAAGLIAWRVAGLKLAAAAVAALLVCGSFGMWVPTMQTLALMIVAVLASVVLGVVLGLAAGLSDRTYRALRPVLDTMQVFPAYAYLLPVVLVFGIGVPAAVLATVVYAAPPMARLTALGLRGADGGVMEAVASLGATARQRLLTARIPLARKQLLLGLNQTIMMALSMAVIASVIGAGGLGDRVYQALASVDVGAALAAGIPIVLLAVILDRTTAAAGTRLGAAEPDGRRLHGPYGWVVAAVLTVVVALVARLADRIDWPDTWTVNIADPVNNTVDWMTDHLYSGVPYIGGTADWAGHFTTWVLDPIRDGLQWLPWWSVLLIVAALAWLIGTWRTAVTAVLAMAAIGVLGVWKPSLDTLSQVLAAVAVTLVVGFAVGIAAARSERLERVLRPVLDVFQTMPQFVYLIPVVALFGVGRAPAVAAAVVYALPAVVRITTQGLRHVDGAAMESARSMGATSGQQLRQVQLPLARSALLLAVNQGVVLVLAVVIIGGLVGGGALGYDVVFGLAQGDLATGLVGGAAIVCLGLMLDRVTQPTERRAKKGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JSV6</accession>
    <name>A0A2M9JSV6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_19750</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000006">
        <property type="protein sequence ID" value="PJN09964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN09964">
        <property type="protein sequence ID" value="PJN09964"/>
        <property type="gene ID" value="CG723_19750"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00060">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000253">
        <property type="entry name" value="FHA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SSF49879"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN09964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="246" mass="27120" checksum="26F7D2D8BCAC74FE" modified="2018-04-25" version="1">MYSIVVVPPLTEPPCSHAQFRLAPGERLTFGRSADNDLAIDHEGVSRAAGEITAHGAFWILGNLSSRQTYVVENPEGAGEHIKIGPGRLDAPVPFEFSRVVLPAAGELLPFEVWAPRHDYLQTRTRLAGLTTRPAFSVDRTKRYFAVLAALCEPRLRGEPHAPLPTVEQVVERLRPTWPSANRAAVQWNIDYLAVKLRLKPGPDEAETGPRLHGKKESLVSLALRFDLVREEDLAALASPPTRAHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JTY3</accession>
    <name>A0A2M9JTY3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_18420</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000005">
        <property type="protein sequence ID" value="PJN10351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN10351">
        <property type="protein sequence ID" value="PJN10351"/>
        <property type="gene ID" value="CG723_18420"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN10351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="700" mass="72928" checksum="C3B51822B3E3F811" modified="2018-04-25" version="1">MADVWTRKGGDSAPSAEGRGHVPGPLVGREVESQALRTLLENHRLVTVAGEVGVGKSRLAAEAVAGFGARGSVERVLGVGKGRLASDAVAGVGAQGAGPRVMVVRWPGGGQDAGSGGAGPEAPASLTAAVLEAAGGIHGRRRAAGAGAGACAGALAERLRAADVLLLLDDVDPVHAECVGMVQTLLEFVPSLRVLVTARRPLGLGGEAVLRLAPLSAEPADDDRAAPAVELFLERFLARAGAAFDSGDAELNSVADICRYVGGLPLAVELAAEQAARSSVGEVAARLEEHQCWLSAPDMAAPRHRSLRDAVAAAYVLCDRDERIVWARASILAGDFDESTAAFVCAGGGLAPARVPACLTRLAAIGVLTPVRDPGGIREPRYRMAPAAHDFGGERLREAREFEVAAERRAIHFHRVAALAESLWSLGSQPQAVRLVLDEAEGLRAMLEYAPRQPELAAAALESVLNLWFWWAVYDAADEGRRHLLRLLPMCRSDTLLIARGLCLAAWLTAYDDPCGANELLQHAWPAAVLAGDDATIGRIAHVQGMLALHGGDRERAAEQFQEAAGTIPSHAPGGLPPAVSLAALAVTQAERSPRAARRSARRALSQPGISGDAWACLVARHAQAFVDHSDGRSGRARQRAHRALAALDGRLPAPHGCAALRDLITDIDRGSRSGLPTVPVPRGRTAVALPAQVGSGILG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JU83</accession>
    <name>A0A2M9JU83_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">GntR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CG723_18875</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000005">
        <property type="protein sequence ID" value="PJN10423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN10423">
        <property type="protein sequence ID" value="PJN10423"/>
        <property type="gene ID" value="CG723_18875"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07377">
        <property type="entry name" value="WHTH_GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.530">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011711">
        <property type="entry name" value="GntR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008920">
        <property type="entry name" value="TF_FadR/GntR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07729">
        <property type="entry name" value="FCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
        <property type="entry name" value="GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00035">
        <property type="entry name" value="HTHGNTR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00895">
        <property type="entry name" value="FCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00345">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48008">
        <property type="entry name" value="SSF48008"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50949">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH gntR-type" evidence="4">
        <location>
            <begin position="16"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PJN10423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="226" mass="25718" checksum="4D2C07F5353ADF47" modified="2018-04-25" version="1">MTQGQTRDTTSPTGTVWLRDQVCEGIRDQIIDGRLKPGDRLVERDVAEEFGVSRIPVREAIRILMSEGFLQALSPRRIVVKELSRQDVANLFDLREALEVLAARRAAENADEVQLRQMQRLLESARKATLAGRPERVSRANTAFHHHIVETAGNELLAATLEPLEGRLRWLFHQIDDPTSVWEEHRRLYETIAAADPEAAAACALRHVRHYREVALRLLFDAPDTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JUQ1</accession>
    <name>A0A2M9JUQ1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Molybdopterin synthase sulfur carrier subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CG723_15355</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000004">
        <property type="protein sequence ID" value="PJN10593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN10593">
        <property type="protein sequence ID" value="PJN10593"/>
        <property type="gene ID" value="CG723_15355"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016155">
        <property type="entry name" value="Mopterin_synth/thiamin_S_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003749">
        <property type="entry name" value="ThiS/MoaD-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02597">
        <property type="entry name" value="ThiS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54285">
        <property type="entry name" value="SSF54285"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PJN10593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="92" mass="10020" checksum="5C1C2CF24E4ECC89" modified="2018-04-25" version="1">MAIEVRIPTILRTYTDGQKAVEGSGDTLAELFADLETRHTGIQARIVDGEQLRRFVNVYLNDEDVRFLDGITTKLADGDNVTILPAVAGGMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JUV2</accession>
    <name>A0A2M9JUV2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">2-aminoethylphosphonate ABC transport system ATP-binding subunit PhnT</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CG723_15680</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000004">
        <property type="protein sequence ID" value="PJN10649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN10649">
        <property type="protein sequence ID" value="PJN10649"/>
        <property type="gene ID" value="CG723_15680"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008995">
        <property type="entry name" value="Mo/tungstate-bd_C_term_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013611">
        <property type="entry name" value="Transp-assoc_OB_typ2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08402">
        <property type="entry name" value="TOBE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50331">
        <property type="entry name" value="SSF50331"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="5"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="37"/>
            <end position="44"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PJN10649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="351" mass="37415" checksum="CE2E1428133EFBA4" modified="2018-04-25" version="1">MASGIRFDKVSVAYGSNTVLHSLDLTVEPGEVMALLGPSGSGKTTALRAVAGFVRPASGRVLIGDRDVTDLPPHRRGIGMVVQQYALFPHLRVEDNVAFGLKAQKVAKAEIPARVTEALEMTGMASYAKRYPRELSGGQQQRVAIARALAIRPGVLLLDEPLSALDAQLRSGMLAELARLHRELPDVSILYVTHDQVEALTLADRIAVMDKARLQDCGTPQELYRRPRTEFTASFVGNANLLPVQVGSGSVSFAGAQLKVPTGDVASGVSATLCVRPHLVGLGDGPNALTGSVSEVQWRGSTHRLYVDVDGHRLKADLRELRTPPALGDEVTVHFAPEDAVLLSAGVSKDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JV48</accession>
    <name>A0A2M9JV48_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">VWFA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_16310</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000004">
        <property type="protein sequence ID" value="PJN10750.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN10750">
        <property type="protein sequence ID" value="PJN10750"/>
        <property type="gene ID" value="CG723_16310"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021908">
        <property type="entry name" value="DUF3520"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022156">
        <property type="entry name" value="Uncharacterised_YfbK_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12034">
        <property type="entry name" value="DUF3520"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00092">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12450">
        <property type="entry name" value="vWF_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00327">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="SSF53300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50234">
        <property type="entry name" value="VWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VWFA" evidence="2">
        <location>
            <begin position="197"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="49"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN10750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="540" mass="57329" checksum="E06DB5A99C9063C0" modified="2018-04-25" version="1">MRPDSEHRAEDRDRTRASARARRRPWTRGRGRARAAGLVAAALVGGLLVTGCGGGSDGSSAERGKAQRTGPLPGPAPARPSAPAPGTEAEGEQRDIAPTDTPSPTPADYLSTFALDVDTASYGYARRTLADGRLPDPKAVRPEEFINSFRQNYPRPEGNGFSVTADGARAGGEGWSFLRVGLATGPAAPASERPPAALTFVIDVSGSMAEPGRLDLVKQSLGVMTDQLRSDDSLALVTFSDTAETVLPMTRVGGARGRVHDAIDSLEPMSSTNLDAGVRTGYDTAVEGARPGATNRVVLLSDALANTGETDADAILDRISDARREHGITLFGVGVGSEYGDALMERLADKGDGHTTYVSTPEEARKVFCDELPQNIELRAREAKAQVAFDPGTVQRFRLIGYDDRQVADDDYRNDRVDGGEVGPGHTVTALYAVRLRPGASGHVATAGVRWLDPHTRAPHEETTQIEASALDTDVWRSSPGLQLTATAAYFADSLRQGALPGAPTLPQLASHADKLARSAEDEDVRQLAEAIRRADELQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-05-25" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JV83</accession>
    <name>A0A2M9JV83_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Probable allantoicase</fullName>
            <ecNumber evidence="3">3.5.3.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Allantoate amidinohydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3 6" type="primary">alc</name>
        <name evidence="6" type="ORF">CG723_16595</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CB01635</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>allantoate + H2O = (S)-ureidoglycolate + urea</text>
            <dbReference type="Rhea" id="RHEA:11016"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16199"/>
            <dbReference type="ChEBI" id="CHEBI:17536"/>
            <dbReference type="ChEBI" id="CHEBI:57296"/>
            <dbReference type="EC" id="3.5.3.4"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Nitrogen metabolism; (S)-allantoin degradation; (S)-ureidoglycolate from allantoate (aminidohydrolase route): step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the allantoicase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.3.4" evidence="3"/>
    <dbReference type="EMBL" id="NNBL01000004">
        <property type="protein sequence ID" value="PJN10796.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN10796">
        <property type="protein sequence ID" value="PJN10796"/>
        <property type="gene ID" value="CG723_16595"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00395">
        <property type="reaction ID" value="UER00654"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004037">
        <property type="term" value="F:allantoicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000256">
        <property type="term" value="P:allantoin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006144">
        <property type="term" value="P:purine nucleobase metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00813">
        <property type="entry name" value="Allantoicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005164">
        <property type="entry name" value="Allantoicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015908">
        <property type="entry name" value="Allantoicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12045">
        <property type="entry name" value="PTHR12045"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03561">
        <property type="entry name" value="Allantoicase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016516">
        <property type="entry name" value="Allantoicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="SSF49785"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02961">
        <property type="entry name" value="allantoicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 3" id="KW-0659">Purine metabolism</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Allantoicase" evidence="5">
        <location>
            <begin position="53"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="domain" description="Allantoicase" evidence="5">
        <location>
            <begin position="234"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF03561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PJN10796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="382" mass="42248" checksum="C7A6F251D2BAEA28" modified="2018-04-25" version="1">MTTSDATPLEAHGDPHANDAAPYAGGDPYADYRHFGDTESYAELVDLADRRLGAGVIAANDEFFAQRENLLVREPAVFDPEHFGHKGKIMDGWETRRRRGTAESPFPAPEDHDWAIVRLGAPGVIRGIVVDTAHFRGNYPQRISVQAACVEGSPSPEDVTAADVKWEELIAPTPVRGHAANGFTITSERRYTHLRLCQHPDGGVARLRVHGEVVPDPEWLDLLGTFDLLSVLNGGTYEDASDKFYSSPTQIILPGTSRKMDDGWENRRRRVHGTNDWVRFRLAAQGAIRAVEIDTAYLKGNSAGWIALSGRNGDTGEWFEIIPRTRLQPDTLHRFKLAAQAVATHVRLDAFPDGGVARMRLHGSLTETGRDALRDRYGRTEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JVD1</accession>
    <name>A0A2M9JVD1_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 10">ATP-dependent Clp protease proteolytic subunit</fullName>
            <ecNumber evidence="5 8">3.4.21.92</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Endopeptidase Clp</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5 11" type="primary">clpP</name>
        <name evidence="11" type="ORF">CG723_16765</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CB01635</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5 9">Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Fourteen ClpP subunits assemble into 2 heptameric rings which stack back to back to give a disk-like structure with a central cavity, resembling the structure of eukaryotic proteasomes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 5 10">Belongs to the peptidase S14 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.92" evidence="5 8"/>
    <dbReference type="EMBL" id="NNBL01000004">
        <property type="protein sequence ID" value="PJN10823.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN10823">
        <property type="protein sequence ID" value="PJN10823"/>
        <property type="gene ID" value="CG723_16765"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004176">
        <property type="term" value="F:ATP-dependent peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07017">
        <property type="entry name" value="S14_ClpP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00444">
        <property type="entry name" value="ClpP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001907">
        <property type="entry name" value="ClpP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023562">
        <property type="entry name" value="ClpP/TepA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033135">
        <property type="entry name" value="ClpP_His_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018215">
        <property type="entry name" value="ClpP_Ser_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10381">
        <property type="entry name" value="PTHR10381"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00574">
        <property type="entry name" value="CLP_protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00127">
        <property type="entry name" value="CLPPROTEASEP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00382">
        <property type="entry name" value="CLP_PROTEASE_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00381">
        <property type="entry name" value="CLP_PROTEASE_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 5 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 5 8" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5 8" id="KW-0720">Serine protease</keyword>
    <feature type="active site" evidence="6">
        <location>
            <position position="115"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="5">
        <location>
            <position position="115"/>
        </location>
    </feature>
    <feature type="active site" evidence="5 7">
        <location>
            <position position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000549"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PJN10823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="219" mass="24094" checksum="C191C8D4999769F7" modified="2018-04-25" version="1">MNNIPGSGLYTGPQVDNRYVIPRFVERTSQGVREYDPYAKLFEERVIFLGVQIDDASANDVMAQLLCLESMDPDRDISIYINSPGGSFTALTAIYDTMQFVKPDIQTVCMGQASSAAAVLLAAGTPGKRMALPNARVLIHQPSGGTGREQLSDLEIAANEILRMREQLEEMLAKHSTTPIEKIRDDIERDKILTAEDALAYGLIDQIISTRKMNSDAIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JVK4</accession>
    <name>A0A2M9JVK4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_17290</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000004">
        <property type="protein sequence ID" value="PJN10913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN10913">
        <property type="protein sequence ID" value="PJN10913"/>
        <property type="gene ID" value="CG723_17290"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN10913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="72" mass="8301" checksum="0C859B170153D027" modified="2018-04-25" version="1">MLPNTTTSKVSRWDQHGREHTVRVQRSGPRRTIRCDTCGWRKPAQFLPWLKAEEHLAQEHQATVDPSAQGPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JVN8</accession>
    <name>A0A2M9JVN8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="12">ABC transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CG723_17230</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">CB01635</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000004">
        <property type="protein sequence ID" value="PJN10902.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN10902">
        <property type="protein sequence ID" value="PJN10902"/>
        <property type="gene ID" value="CG723_17230"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015833">
        <property type="term" value="P:peptide transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013563">
        <property type="entry name" value="Oligopep_ABC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08352">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01727">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="27"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="92"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="138"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="11">
        <location>
            <begin position="90"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="10">
        <location>
            <begin position="340"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="642"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="376"/>
            <end position="383"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PJN10902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="662" mass="69978" checksum="E2E1B85DB10B1633" modified="2018-04-25" version="1">MVTSRKALAEALSRPGIRLRSLRRLPVLSRIAVAVVAVVVLVALFAPLLAPHDPLDQQSQTDGTGHPSGSHWMGQDSLGRDILSRLMYGARWSLAIGLGATLLALVVGAVLGAIAATSRKAVDETLMRCLDVVMAFPGIALAAVLVAVFGGGIPVLICAIAFLFTPPVARVVRANVLDQYGEDYVTAERVIGARTPHIVLRHVAVNCAAPVLVFCTVQVAEAIVFEASLSFIGAGVRPPDPSWGSVIADGKNMVLIGGWWATVFPGLLMLLTVLALNILSEGVSDAWAAPAARDVSGAEADRLEAPKPGSGTVLELPGLTEAAARLRSRARPLPEGDPVLQVTDLTIGFDARHGGVDIVDGITFDVRPGEVLGLVGESGCGKSLTALTVMGLEPKGARIRGRVTFDGQELIGRSMGARRRLLGHDMAMIYQDALSSLNPAMTVRSQLKQVVRRGGRRTPAELLSLVGLDPERTLRSYPHELSGGQRQRVLIAMALSRSPKLIVADEPTTALDVTVQAQVIELLLRLREELGFALILVSHDLALVADVTDRVVVMYGGQIVETGVTADLVEAPTHHYTRGLLGSVLSLETAADRLTQIRGVVPSPADFPAGCRFADRCPMASEVCRTTAPDLLGGRRHASACHHPAVVPPPTVPAPRGSEVVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JVW3</accession>
    <name>A0A2M9JVW3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CG723_08330</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CB01635</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic/archaeal PrmC-related family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN10999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN10999">
        <property type="protein sequence ID" value="PJN10999"/>
        <property type="gene ID" value="CG723_08330"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044260">
        <property type="term" value="P:cellular macromolecule metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043412">
        <property type="term" value="P:macromolecule modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006807">
        <property type="term" value="P:nitrogen compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044238">
        <property type="term" value="P:primary metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002052">
        <property type="entry name" value="DNA_methylase_N6_adenine_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004557">
        <property type="entry name" value="PrmC-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007848">
        <property type="entry name" value="Small_mtfrase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05175">
        <property type="entry name" value="MTS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00537">
        <property type="entry name" value="hemK_rel_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00092">
        <property type="entry name" value="N6_MTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="MTS" evidence="3">
        <location>
            <begin position="17"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PJN10999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="229" mass="24399" checksum="1A9CA7CB53525A44" modified="2018-04-25" version="1">MTAEVQSAPAPSRPPRLLTPPGVYAPQRDTQILVQALCGENIGPTTRVLDLGTGSGALAVQAARMGARVTAVDISWRAVWAARLNARLSRHHVTVRRGDLTNALQGRSYDIIVSNPPYVPCPSVGLPSRGKARSWDAGPDGRALVDRICDAAPAALRPGGALLLVQSALSGTEATLERLAGTGLHPAVVDRAHIPFGPVLRSRTAWLRRRGLVGEESWEELVVIRAEKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JVX6</accession>
    <name>A0A2M9JVX6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_08660</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN11046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN11046">
        <property type="protein sequence ID" value="PJN11046"/>
        <property type="gene ID" value="CG723_08660"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014909414" evidence="1">
        <location>
            <begin position="38"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN11046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="225" mass="23860" checksum="0924F9398119D2E9" modified="2018-04-25" version="1">MSHRKPRTSTVGRTAMRLGMLTTVCLTGLATVTPAGAATGSRITSGVGIAVDEARSLANPRHRIDHDEEFTIHQLGTVVGAGVRNRAIARSVGCSIDAPCRSIALSFQIVTTNGAARLNASNTSKAVNDHCEGCETFAGAYQFIVSTPYRFTLSSATRNKLGAYERRLAALERSREPIDVVKGHADALAAEIVSLLQHGVAAAPHGKTVDPLGLRPTVTLRRHID</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JW25</accession>
    <name>A0A2M9JW25_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_08575</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN11032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN11032">
        <property type="protein sequence ID" value="PJN11032"/>
        <property type="gene ID" value="CG723_08575"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="78"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="110"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="136"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN11032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="176" mass="19757" checksum="18836887F28C980E" modified="2018-04-25" version="1">MSDSGDRLALLKGIRAWLVLFVVCLVLSGATAFPLVHELHWTEDLLRSLSVPEHLPALMDWIEHVRQGIDVADEEYPFLLYGTDWLAFAHLVIAVAFYGPYRDPVRNIWVVEFAMIACAGIIPLALICGPLRGIPFWWSVIDMSFGVFGVIPLYVVRRKIKRLEALTSPVPLAMAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JWB0</accession>
    <name>A0A2M9JWB0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CG723_09545</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN11181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN11181">
        <property type="protein sequence ID" value="PJN11181"/>
        <property type="gene ID" value="CG723_09545"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014728358" evidence="3">
        <location>
            <begin position="35"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="390"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="119"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="317"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="127"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="362"/>
            <end position="377"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PJN11181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="419" mass="41935" checksum="13A36F2B2419AC71" modified="2018-04-25" version="1">MSVRGSLSLPLRARALSGAGTVALLVFLPTAAGAAEPGDSEGSDCPVTATAQGVQVTVSASNDTLLQAPTGVGVPVARACVNYAVGESSGWAGSPYPGETVISAPALIGSQTGQKFPDYPAYAASTYPSDESATSGQDPHVMRSHSTKTSTKAQASTVLGQDAAAASTTAMAHTSVDPDALTGKATATSDTKPWAVNGVLELGRVLSSATATVDRDGKVVRDSELSIGRTEIAGQGVEISPDGLKVVGQTAPLPDAADPAKALAAAGIKIRYLDEKRTEQGVVSAGLEVQARQQDTQSGAVYTVTYVFGRASADAGRIEAPPGSGSVPPARVPQAPSDAGGGGDAADSQVPADDTPAAPKAPSDDGSSTPQDTRPVQLAASPTDMGVTGIYLVLALGAVATFAAGTLLRLLGVKTRWTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JWD1</accession>
    <name>A0A2M9JWD1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Alpha-1,3-galactosidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_09400</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN11159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN11159">
        <property type="protein sequence ID" value="PJN11159"/>
        <property type="gene ID" value="CG723_09400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006626">
        <property type="entry name" value="PbH1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024535">
        <property type="entry name" value="Pectate_lyase_SF_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12708">
        <property type="entry name" value="Pectate_lyase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00710">
        <property type="entry name" value="PbH1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="SSF51126"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014760773" evidence="1">
        <location>
            <begin position="26"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="domain" description="Pectate_lyase_3" evidence="2">
        <location>
            <begin position="34"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN11159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="619" mass="66897" checksum="73549D5390C89427" modified="2018-04-25" version="1">MPKSRFLFLGLALALFGGAAGPVVAAPGARPVVVDVDDYGADPTGRTDSTPAVTAALRHARSIDRPVRIVFSQGTYQLYPERAEKRELYVSNTVGADQRYRDKKIGLLVEDMHDVTLDGGGAKLVYHGLQTAFASIRSTNVTFTNFSFDYAAPEVIDATVADTGVADGHAYRVLKIPAGSPYQVNGTHITWLGEKSPATGQPYWSGVDGLQYTQIHDPKAERTWRGDNPLFNDVAAVSDLGGRRIRIDYTTAERPADAGLVYQMRLIERTEPGAFIWQSKNVTMRSMNAYYLQSFGVVGQFSENISIDKVNFAPDPKSGRSTASFADFVQMSGVKGKVSITRSLFDGPHDDPINIHGTYLEVVGKPGPNTLTLAYKHPQTAGFPQFAPGDEVEFTTKRTMAPPADAHAKVTAVDGPSGMDHDKPLTTMTVTFDRPVPAGVETGGTVVENITATPSVVISGNVFRNVPTRGILVTTRKPVLITGNRFDAMSMASIYVSADAYQWYESGPVADLTIRGNSFTRPSGPVIFVEPTNQVVDPANPVHHNISVEHNSFDIGDVTVVDAKSVGGFAFTGNTVRRLDAADQPPYTSPLFVFHGSSGIRIAHNHYDEGLNTDWQANG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JWL2</accession>
    <name>A0A2M9JWL2_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF4142 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CG723_10175</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN11291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN11291">
        <property type="protein sequence ID" value="PJN11291"/>
        <property type="gene ID" value="CG723_10175"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025419">
        <property type="entry name" value="DUF4142"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13628">
        <property type="entry name" value="DUF4142"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014993652" description="DUF4142 domain-containing protein" evidence="2">
        <location>
            <begin position="30"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4142" evidence="3">
        <location>
            <begin position="54"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="203"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="208"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="232"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13628"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PJN11291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="258" mass="27263" checksum="F9AF27AA20FD451C" modified="2018-04-25" version="1">MRRINGTALIFAALVATLGALAFPIWSYADRSGTGAANLNAGSVATQWGPLSATDRDFLVKVRLAGLWEIPAGQQAMERAPTQAIRMAGDHLVVGHTDLDKRVRSVAGRLGVELPNQPNPQQQGWLNQLTAASGKDYENKFANLLRDSHGKVFALIAQVRHTTRNTLVRELATDANQTVLDHITMLENTGDVDFDAIANEAAGTATASPTGPPPPGGVLPPAPPPAEPSGSPYVTSQPSAEPTDDPGRSINTDRPDPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-05-25" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JWU0</accession>
    <name>A0A2M9JWU0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">LacI family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CG723_10465</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN11344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN11344">
        <property type="protein sequence ID" value="PJN11344"/>
        <property type="gene ID" value="CG723_10465"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01392">
        <property type="entry name" value="HTH_LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000843">
        <property type="entry name" value="HTH_LacI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046335">
        <property type="entry name" value="LacI/GalR-like_sensor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00356">
        <property type="entry name" value="LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13377">
        <property type="entry name" value="Peripla_BP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00354">
        <property type="entry name" value="HTH_LACI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50932">
        <property type="entry name" value="HTH_LACI_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH lacI-type" evidence="5">
        <location>
            <begin position="23"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PJN11344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="347" mass="37531" checksum="1AA8AA170CA182A4" modified="2018-04-25" version="1">MVQIPKPQSARTSRESAAPSPAPTSADVARLAGVSRATVSYVLNNTSAVRISEPTRRRVHEAAKELGYVPHAAARSLRAGHTRIVLMPSPSVPAGPLYNTFFNDLQWALSRLDYTVVQYGSVSLRGDDAARAWAELRPVAVLTPPDLGTEGVEVLRRSGARAVITLGPERAEGAHALLMDHREVGHSAGAHLVERGRRRIGVVLPTEPGLDHFARPRLEGIRNEVLGTGAAVFELPLTYDEDSAAQLVPRIRELGIDAVFAYNDEYAMLLMRALQDAGVGIPEETAVIGADDLMLGRLLRPRLSTVRIELPSGQELAALVDRLVRDPGAVTESHDMLRARVVARQST</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JX49</accession>
    <name>A0A2M9JX49_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">GPP34 family phosphoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CG723_11135</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CB01635</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN11455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN11455">
        <property type="protein sequence ID" value="PJN11455"/>
        <property type="gene ID" value="CG723_11135"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043231">
        <property type="term" value="C:intracellular membrane-bounded organelle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070273">
        <property type="term" value="F:phosphatidylinositol-4-phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3630.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008628">
        <property type="entry name" value="GPP34-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038261">
        <property type="entry name" value="GPP34-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05719">
        <property type="entry name" value="GPP34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="104"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PJN11455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="201" mass="21580" checksum="0CDCBC5B947AB682" modified="2018-04-25" version="1">MTTARDLAIVALAETPDHPVEQGELSLALAGAEVFDLIEAKALIVDGDRILPSAQATTGDRLLDEAAAALVRQEPYESVEDWLWRRGRGLSSAYVDELEREGLTARPRGHRNPLRSGRTEPVDSAERGRTEERWAAGEPVLVALAAAAGIRDEPAGDAPELAGDPVAAVLAAVGNAVQELQAVRQRRAIEDAAFDNVWRGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JXG0</accession>
    <name>A0A2M9JXG0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_11810</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN11570.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN11570">
        <property type="protein sequence ID" value="PJN11570"/>
        <property type="gene ID" value="CG723_11810"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002397">
        <property type="entry name" value="Cyt_P450_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00359">
        <property type="entry name" value="BP450"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="SSF48264"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0349">Heme</keyword>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN11570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="401" mass="44831" checksum="D1EDC4BC64ED6B7E" modified="2018-04-25" version="1">MTVTPPTPDTVAFPQDRTCPYHPPASYDPLRSARPLSRVSLYDGRTVWVVTGQSTARDLLIDPRLSTDRENRAFPMPTERFALSRKRRIALLGVDDPEHNTQRRMLIPSFTLKRITALRPRIQEIVDRLLDAMVEQGPTADLVSAFALPVPSMVICSLLGVPYADHDFFEEQSRRLLRGPDVTDTEAAREQLDAYLGSLIDRKRREPGDGLLDELIHRGPDEKEIDREELISLATILLIAGHETTANMISLGTFTLLRHPDLLEELRSADSLLPAAVEELLRFLSIADGILRVATEDIEVAGETIRADDGVVFSTSLINRDEDSFTAPDSLDWHRPTRHHLAFGYGVHQCLGQNLARAEMEIALRSLFARLSGLRLAAPAEEIPFKPGDTIQGMLELPVTW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JXR7</accession>
    <name>A0A2M9JXR7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ABC transporter substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_12420</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN11670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN11670">
        <property type="protein sequence ID" value="PJN11670"/>
        <property type="gene ID" value="CG723_12420"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006059">
        <property type="entry name" value="SBP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01547">
        <property type="entry name" value="SBP_bac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014883511" evidence="1">
        <location>
            <begin position="28"/>
            <end position="430"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN11670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="430" mass="46147" checksum="08D3D2769564FAFD" modified="2018-04-25" version="1">MPISRRALAAAAAIAFVLPLSACGSGGDDSGSTDATGKIEGSITFQTWNLRANFKPYFDGLVKDFEKKYPGTHVKWIDQPGEGYADKISADAAGGTLPDVVNVSPDLVAPLAKAGLALDLDKAASKYKKEYLPGAWASHQIPGMDGTYAFPWYLNTGPLFYNKSLFKQAGLDASQPPKTYDALFDDALQLAKKSKGKVATLANVPTIEDFGRYGAPLMNKEGTGFAFNDAKGVELLTKYKELYDAKALDPQALTATPESTGKKFLTGAVAMNPGSALDLSKFKKDAPSLYKNIGITDQITSTGKVNMYVMGVMVNSRSKQKPAAVAFAHYVTDAQHQMEFAKKVAIFPSTAGSLDDPYFTKQDGSDETRVRIAAADSLKSAVNYTPVLFSEQMKTELRNSVAKALQGKESPKTALDNAVKACDRLLQQQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JXV4</accession>
    <name>A0A2M9JXV4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CG723_12635</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN11704.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN11704">
        <property type="protein sequence ID" value="PJN11704"/>
        <property type="gene ID" value="CG723_12635"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PJN11704.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="152" mass="17047" checksum="7B16F3013F7A0CB4" modified="2018-04-25" version="1">MEYSHNDAELIEQPIGYWAWAAYKAVVTRTRGALAEKGTTQPQWWVLAQVARAEHVKTRGEVSETLRGYLDVGEVVLVEEIDATIARGWLTEDAAGRLSPTAAGKDFFDELAALQGELWTERHAGVSDEDYLTTLKVLQRFIHNTGGRAWHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JXW2</accession>
    <name>A0A2M9JXW2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Threonine dehydratase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CG723_12620</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CB01635</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN11701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN11701">
        <property type="protein sequence ID" value="PJN11701"/>
        <property type="gene ID" value="CG723_12620"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901607">
        <property type="term" value="P:alpha-amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="PLP-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000634">
        <property type="entry name" value="Ser/Thr_deHydtase_PyrdxlP-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="Trypto_synt_PLP_dependent"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="SSF53686"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00165">
        <property type="entry name" value="DEHYDRATASE_SER_THR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PALP" evidence="3">
        <location>
            <begin position="36"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PJN11701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="324" mass="33338" checksum="E4B152808BFB6A2B" modified="2018-04-25" version="1">MTIAFHDVRAAADRIAGHTRPLVMAPLGDGAFDGAFGEAEGWLALEFMQHTGSFKARGAFNFVSSHIEAGLMPDAGVVIASGGNAGLACAWAAARHSVQATVFVPETAPAVKVDRLRLLGATVRQVGSEYAEALAASQKDAAERGALESHAYDHPLIAAGAGTVMEEIVQARPGIDTVLVSVGGGGLFTGIAASAREHGVRVVAVEPERCCALHSALQAGAVVDVPVDSVAADSLGARRTSEMALEWAGQDHVRSVLVTDEAIVSARQALWDDRRLAVEHAAATALAAVTSGVYTPAPGERVAVILCGANTDPGDLTRSARLPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JYP2</accession>
    <name>A0A2M9JYP2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CG723_14435</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN12003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN12003">
        <property type="protein sequence ID" value="PJN12003"/>
        <property type="gene ID" value="CG723_14435"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PJN12003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="318" mass="33076" checksum="7DADFAC6CEC863D5" modified="2018-04-25" version="1">MTAPQTPRTFGATTTAAEILDGVDLHGRRAVVTGASSGIGVETVRALTAAGADVTLAVRNTDAGARVTERLEAELPSSSGKLTVGRLDLADRSTVTEFVSAWDGPLHILVNNAGLMAPPEVARTPDGREMQFGVNHLGHFALAVGLHPALAAAGGARVVSVSSIGHLFSPVVFDDLDYRFRPYDPWTSYGQSKTANALFAVGAAERWADDGITANALMPGNIADTSLARHMDMQQVADFIASGELALPPGKTVEQGAATSVLVAASPTVEGITGRYFEDCAEAKPVTQRAGTVAGVAPYALDPDNAARLWAVSEAFVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JYY0</accession>
    <name>A0A2M9JYY0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">MarR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_14840</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN12070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN12070">
        <property type="protein sequence ID" value="PJN12070"/>
        <property type="gene ID" value="CG723_14840"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000835">
        <property type="entry name" value="HTH_MarR-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12802">
        <property type="entry name" value="MarR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00598">
        <property type="entry name" value="HTHMARR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00347">
        <property type="entry name" value="HTH_MARR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50995">
        <property type="entry name" value="HTH_MARR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH marR-type" evidence="2">
        <location>
            <begin position="16"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="161"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN12070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="231" mass="24875" checksum="B2D6AC79D97C0F3A" modified="2018-04-25" version="1">MSTETPATPVGGVDVAGDFGLCLLALMRGYRTVVASALDDVSQGARGYQTLAVVVRGDQQNLLALATYLGIDRTLMTYLIDDLVTAGFVERRLDPADRRQRKIVVTARCVNTPQDLQRQIREAEDRLLEAFDENERQTFRTLLSRVACGVRNVDLAAAPCDVRSDPATSPNSGPSSTAYPPARAGRRPDRPAGHRIPPRMRRPLGRGGIGLLGSRAERAGSSAGRSGVHLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JZ10</accession>
    <name>A0A2M9JZ10_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Alpha-L-fucosidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CG723_09810</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CB01635</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Alpha-L-fucosidase is responsible for hydrolyzing the alpha-1,6-linked fucose joined to the reducing-end N-acetylglucosamine of the carbohydrate moieties of glycoproteins.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN12123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN12123">
        <property type="protein sequence ID" value="PJN12123"/>
        <property type="gene ID" value="CG723_09810"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004560">
        <property type="term" value="F:alpha-L-fucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006004">
        <property type="term" value="P:fucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016286">
        <property type="entry name" value="FUC_metazoa-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000933">
        <property type="entry name" value="Glyco_hydro_29"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10030">
        <property type="entry name" value="PTHR10030"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01120">
        <property type="entry name" value="Alpha_L_fucos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001092">
        <property type="entry name" value="Alpha-L-fucosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00741">
        <property type="entry name" value="GLHYDRLASE29"/>
    </dbReference>
    <dbReference type="SMART" id="SM00812">
        <property type="entry name" value="Alpha_L_fucos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="131"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="site" description="May be important for catalysis" evidence="5">
        <location>
            <position position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR001092-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PJN12123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="419" mass="47048" checksum="07A612BFC114B233" modified="2018-04-25" version="1">MQPWFTDGKLGIFLHWGIYSVDGVAESWSFFNGQVPYDTYMAQLDGFDAQKWDPDAWADLFVEAGAAYAVLTAKHHDGVALWDTQANDLSVVKRTPAARDLITPYVDALRRRGLKVGLYYSHLDWSHPDYATVRPDGQDPDDRGNPYSMPAVDDESPERWDAFLAFHRAQVRELLGLFQPDLLWFDGEWERSPEQWRMVELAALIAELSPHTVVNGRLTGHGDYATPEQGVPVEPPKGPWELCLTVNDSWGFQPQDDHHKSPRQLVRVFAETVGGGGNLLLAVGPKADGTIPPVQAERLEALGEWIAGHRPAVRDTVRGLPHGHFYGPSTLSADRRTLYLFLFDRPNEYVVLRGVRNAVRSARVLGSGTDVRHERVGGLGEVPGWEYLYVTDDQLDPLCTVVSLELDGELDLYREHTRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-09-29" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JZD6</accession>
    <name>A0A2M9JZD6_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Beta-N-acetylhexosaminidase</fullName>
            <ecNumber evidence="3">3.2.1.52</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CG723_04095</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CB01635</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal non-reducing N-acetyl-D-hexosamine residues in N-acetyl-beta-D-hexosaminides.</text>
            <dbReference type="EC" id="3.2.1.52"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 20 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.52" evidence="3"/>
    <dbReference type="EMBL" id="NNBL01000002">
        <property type="protein sequence ID" value="PJN12253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN12253">
        <property type="protein sequence ID" value="PJN12253"/>
        <property type="gene ID" value="CG723_04095"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004563">
        <property type="term" value="F:beta-N-acetylhexosaminidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102148">
        <property type="term" value="F:N-acetyl-beta-D-galactosaminidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.379.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025705">
        <property type="entry name" value="Beta_hexosaminidase_sua/sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000421">
        <property type="entry name" value="FA58C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015883">
        <property type="entry name" value="Glyco_hydro_20_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029018">
        <property type="entry name" value="Hex-like_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015882">
        <property type="entry name" value="HEX_bac_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00754">
        <property type="entry name" value="F5_F8_type_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00728">
        <property type="entry name" value="Glyco_hydro_20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02838">
        <property type="entry name" value="Glyco_hydro_20b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00738">
        <property type="entry name" value="GLHYDRLASE20"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="SSF49785"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55545">
        <property type="entry name" value="SSF55545"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50022">
        <property type="entry name" value="FA58C_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014929077" description="Beta-N-acetylhexosaminidase" evidence="6">
        <location>
            <begin position="42"/>
            <end position="794"/>
        </location>
    </feature>
    <feature type="domain" description="F5/8 type C" evidence="7">
        <location>
            <begin position="529"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="domain" description="F5/8 type C" evidence="7">
        <location>
            <begin position="652"/>
            <end position="794"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="547"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="676"/>
            <end position="695"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PJN12253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="794" mass="86814" checksum="03640A8198B11057" modified="2018-04-25" version="1">MPPSNGSISPRLSRRSFVTALAVTSAVTALPLGLGSAAARAAGGNAANERPVVIPALQNWAGSTGRYRLEAGAPIVVQAAKASELLALARQFADDIEEVTGIRPGVPRAGRGVRGGLRLVLDPADRHAPGGDRYAEEGYTLRVTAAAVTVTAPTRTGLYYGTRSVLQILLRSDGRRELPTGTAHDWPDYRLRGFMLDAGRRFFTPGFIRDQLRLMGWFKLNDLQLHLNDNEISPAGGDWSQAYDAFRLRSDKPEWAGLAAPDGSYSRGDWDSFEDTAAAHAVQLTPEIDAPAHARSFVRFRPELGLKGGNSDHLDLAKPETTAFMKKVFDEFAPWFRSPEIHYGADEYTGPEEQYRGYFNAMAAHLRTLGKHPRAWGSLTEMAPSGTSGYDRDVTIHSWNNGWYGPKAATADGYEIVNTNDGLLYVVPFATYYHPLGLDGPYLYESWAPHVFPGDQSLQPHDPKLRGAMSAVWNDLVHATYTQQAVHGLVEKTFGTLAQKMWSGSGAGLSYRDFTAELRRGIAGPGLTTLTPTLAEPDQISLDAPATASSTAAGTRPVYATDGSPVTRWTSGRERAPWLAVDLGQSRPVQRVRVEWGPEHGTAYAVEVSDDGVAWRTVAERTGRDRAGWDELGFPATTARHVRLRGRERASTRYSVWSLQVYDIPDLALGRPTTASSAETATLTAPNATDGDPGTRWASKYTDGEWIEVDLEQTRTVRRIVLDWETAAGRDYDLQVSADATGSSWRTVAARQGRTTAGVDTVDLDAVQARRVRMLGVKRQTTYGYSLYRFEVRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JZF5</accession>
    <name>A0A2M9JZF5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Class F sortase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CG723_04150</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000002">
        <property type="protein sequence ID" value="PJN12262.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN12262">
        <property type="protein sequence ID" value="PJN12262"/>
        <property type="gene ID" value="CG723_04150"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05829">
        <property type="entry name" value="Sortase_F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005754">
        <property type="entry name" value="Sortase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023365">
        <property type="entry name" value="Sortase_dom-sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042001">
        <property type="entry name" value="Sortase_F"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04203">
        <property type="entry name" value="Sortase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63817">
        <property type="entry name" value="SSF63817"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="38"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PJN12262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="214" mass="22227" checksum="C176607AE4140A08" modified="2018-04-25" version="1">MPQARRRRVSSGLIAAVTTLALCLGAWLLLQGTEIHGPPQPSTAQAGSALPGTGHEPPGAAPLSSSPPDRIRIPSIRVDAPLMGLALTPQGSLGVPPPEQKNLAGWYDAGTAPGVRGTAVVAGHVDNAEGPAVFYDLGALTRGRTIEVDRRDGSVAVFTVDAVEVYDARAFPDEKVYGAADRPELRVITCGGGYSKQTGYRGNVVVFAHLTGSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JZU4</accession>
    <name>A0A2M9JZU4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Prenyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CG723_04995</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000002">
        <property type="protein sequence ID" value="PJN12405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN12405">
        <property type="protein sequence ID" value="PJN12405"/>
        <property type="gene ID" value="CG723_04995"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="SSF48208"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PJN12405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="361" mass="39664" checksum="F0E6847262ED437F" modified="2018-04-25" version="1">MTSPEKTEHLVLPGVLTAEQAAATVRGLLAVQREDGAIPWFRGHHLDPWDHTEAAMALDAAGEHDAAERAYDWLARHQNEDGSWYAAYADGDAGDITDHGRETNFVAYVAVGAWHHYLSTGDDAFLDRIWPTVYAAMEFVLRLQQPGGQIGWKREPDGTPVNEALLTGSSSVHHALRCALAIAEEREEPQPDWELAAGSLRHAIRRHPERFLDKNRYSMDWYYPVLGGALTGTEAEERIQESWDRFVVPGLGVRCVVPNPWVTGGESAELALALWAVGESDRALEILQSIQHLRDPESGLYWTGYVFDDRAVWPLELTAWTAGSVLLAVAALGGDEATCSVFGGRLPAGFEPDCCEGSPAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-05-25" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JZW4</accession>
    <name>A0A2M9JZW4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_04960</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000002">
        <property type="protein sequence ID" value="PJN12398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN12398">
        <property type="protein sequence ID" value="PJN12398"/>
        <property type="gene ID" value="CG723_04960"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="69"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="72"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN12398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="88" mass="9264" checksum="D16A6CF18516ED3C" modified="2018-04-25" version="1">MAPDEAVVGCTGKLVIATRGAEGPGEVLVRVRGGSETFLAWSDEPMERGSTVLVIESRGTRQVVVMAWSDPSLDDERTDGSGDTGDAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K041</accession>
    <name>A0A2M9K041_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Alpha-N-acetylglucosaminidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CG723_05570</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000002">
        <property type="protein sequence ID" value="PJN12503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN12503">
        <property type="protein sequence ID" value="PJN12503"/>
        <property type="gene ID" value="CG723_05570"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.379.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029018">
        <property type="entry name" value="Hex-like_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007781">
        <property type="entry name" value="NAGLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024732">
        <property type="entry name" value="NAGLU_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024240">
        <property type="entry name" value="NAGLU_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024733">
        <property type="entry name" value="NAGLU_tim-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12872">
        <property type="entry name" value="PTHR12872"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05089">
        <property type="entry name" value="NAGLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12972">
        <property type="entry name" value="NAGLU_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12971">
        <property type="entry name" value="NAGLU_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014715280" evidence="2">
        <location>
            <begin position="31"/>
            <end position="1034"/>
        </location>
    </feature>
    <feature type="domain" description="NAGLU_N" evidence="4">
        <location>
            <begin position="40"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="domain" description="NAGLU" evidence="3">
        <location>
            <begin position="134"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="domain" description="NAGLU_C" evidence="5">
        <location>
            <begin position="464"/>
            <end position="727"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF12971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF12972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PJN12503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="1034" mass="111744" checksum="1791E7361CB61516" modified="2018-04-25" version="1">MTAPSRRSVLGTAGAIGLGAAAGFPVTAHAAEGPAFDTAPVRSALNRLLPGHADQFRLRFLSPQDGGDRFRVTGTRGSVEVAGTTPAVMLTGVHWYLKYVCGAHIAWNGSQLDLPKTLPAPPRPLERSTALPHRFALNDTNDGYTAPYADWPYWERMIDVLALHGCNEVLVIAGTEAVYERVLKDFGYSDAESRAWLPAPTHQPWWLLQNLSGYGGPLSPELIAKRVELGRRITDRLRELGMSPVFPGYYGHVPHGFVERNGGDAHIVPQGTWHGFDRPDWLDPRTQSFADVAASFYGHQRDLFGAAGHFKMDLLHEGGTAGDVPVPDAARGVEKALQKAHPGATWVILGWEANPLPALIDAIDKKRMLIVDGVCDRFTTVTDREKDWGGTPYAFGTIPNFGGRTTIGARAHIWNEKFFAWRDKPGSALAGTAFMPEGTDRDPAAFELFSELAWTEGKVDRAAWFSGYADFRYGVRDADARAAWRALHDTAYQHTAVERSDAHDSLFCARPDLAANRAAEYAPRALAYDPGRFDAALSGLLGVAGGLRSSAAYKYDLVDVARQALAHRSRQLLPQLRAAYARKDRDAFRRLATLWLKLMRLSDDVTGTHPAFLLGPWIDDARRLATSDAERAEFERTAKVLITVWGDRATSDPGSLHEYANREWHGLMSDFYVPRWQKWLDALEDALATGSAPAAVDWFAFEEPWTVERKDYPLRPIGDAYKTATRVRDVLARAPYQGSLTVTAQPTVFPPGGHARVEAAFRNVNGLRATGRVDFTLSGIDAAPEGSTSLGSVAPAGTGTVRWQASAPGTPLDRPLRPLPYELTVRYGPQGEDRVTSVHAGTLFEAGPLDGAWRTVTDNAAVFGQLGDRYAIDGAGADLWKGTTEFGSAYREGAFTDGSSAEVTVTAQAATGPWARAGLIVRNSLAAPGSPGFLNLSATPSNGVVLSYDTNGDGTLDTYRRITGIKAPVALRLTRSGGSYTGECSTDDGATWRTVATVAVPGVATTQDVGLFMTATNGGGGARGTVEFGGWQLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K0I8</accession>
    <name>A0A2M9K0I8_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 13 14">UDP-N-acetylmuramoylalanine--D-glutamate ligase</fullName>
            <ecNumber evidence="5 13 14">6.3.2.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">D-glutamic acid-adding enzyme</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="primary">murD</name>
        <name evidence="17" type="ORF">CG723_06230</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">CB01635</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13 14">Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 13 14">
            <text>ATP + D-glutamate + UDP-N-acetyl-alpha-D-muramoyl-L-alanine = ADP + H(+) + phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamate</text>
            <dbReference type="Rhea" id="RHEA:16429"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29986"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83898"/>
            <dbReference type="ChEBI" id="CHEBI:83900"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.2.9"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 13 14">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 13 14">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 13">Belongs to the MurCDEF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.9" evidence="5 13 14"/>
    <dbReference type="EMBL" id="NNBL01000002">
        <property type="protein sequence ID" value="PJN12626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN12626">
        <property type="protein sequence ID" value="PJN12626"/>
        <property type="gene ID" value="CG723_06230"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004326">
        <property type="term" value="F:tetrahydrofolylpolyglutamate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008764">
        <property type="term" value="F:UDP-N-acetylmuramoylalanine-D-glutamate ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007049">
        <property type="term" value="P:cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00639">
        <property type="entry name" value="MurD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018109">
        <property type="entry name" value="Folylpolyglutamate_synth_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036565">
        <property type="entry name" value="Mur-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004101">
        <property type="entry name" value="Mur_ligase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036615">
        <property type="entry name" value="Mur_ligase_C_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013221">
        <property type="entry name" value="Mur_ligase_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005762">
        <property type="entry name" value="MurD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02875">
        <property type="entry name" value="Mur_ligase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08245">
        <property type="entry name" value="Mur_ligase_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53244">
        <property type="entry name" value="SSF53244"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53623">
        <property type="entry name" value="SSF53623"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01087">
        <property type="entry name" value="murD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01011">
        <property type="entry name" value="FOLYLPOLYGLU_SYNT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11 13 14" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="8 13 14" id="KW-0132">Cell division</keyword>
    <keyword evidence="9 13 14" id="KW-0133">Cell shape</keyword>
    <keyword evidence="12 13 14" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="7 13" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="13 17" id="KW-0436">Ligase</keyword>
    <keyword evidence="13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10 13 14" id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mur_ligase_M" evidence="16">
        <location>
            <begin position="124"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="domain" description="Mur_ligase_C" evidence="15">
        <location>
            <begin position="335"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="126"/>
            <end position="132"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00015655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00639"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU003664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF02875"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF08245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="PJN12626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="482" mass="50144" checksum="9F3181FBD0DE1658" modified="2018-04-25" version="1">MGSRQVTTGSDWQNKRVTVAGLGVSGISAARALAGLGASVTVVDGGDSEAHRAKAAELAQLGVAARLGDAETLPEGTELVVTSPGWKPSSPLFAAAAQAGVDVVGDVEIAWRLRGPGAAPWLAITGTNGKTTTTQMLASILEAAGLRTAAVGNIGTPIIDVVLEGDDAYDVFAVELSSYQLHWAPSLRAHSGAVLNLAPDHLDWHGSMEAYAADKGRIYEGNQVACVYNADATDKPSTEDLVREADVEEGCRAIGFTLGTPGPSQLGVVDGILVDRAFVDNRHKNAQELAEVADVDPPAPHNIANALAAAALARAFGVEPAAVRDGLRAFTPDAHRIAHVADVDSVAYVDDSKATNTHAAEASLAAYESIVWIAGGLAKGATFDELVTRSAKRLRGVVLFGQDRALIREALARHAPHVPVVDLDRTDTGAMSQAVREAARLARPGDTVLMAPACASMDMFTNYNKRGDAFAEAVRELGSTSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K0M2</accession>
    <name>A0A2M9K0M2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">LLM class flavin-dependent oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_06580</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000002">
        <property type="protein sequence ID" value="PJN12683.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN12683">
        <property type="protein sequence ID" value="PJN12683"/>
        <property type="gene ID" value="CG723_06580"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011251">
        <property type="entry name" value="Luciferase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036661">
        <property type="entry name" value="Luciferase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00296">
        <property type="entry name" value="Bac_luciferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51679">
        <property type="entry name" value="SSF51679"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bac_luciferase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN12683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="377" mass="41907" checksum="7C77AD3A4EEED257" modified="2018-04-25" version="1">MKFSMIFEAQLADPTPENERQVLRDCVDQAVFAEEMGFDRIWAVEHHSLTQYAHMSASEIFLTWVAARTSRIRIGHGVVTMPFGYQHPVRVAERAAMLDSLTGGRVDIGAGRGATKQEMRMYGVRPEDTYPQMEEALRIFSSAWREEQFEWHGSIDIGPGAILPRPVQTPHPPLFMACSKHDTLKLAAELGIGALVMGFAGADDVRTMRKVYDEAIATRTGERFVSTEVNDHLSALCPTVVLDDADLALRLGTRGQRFFAESIAHWYGNAPAPTSYAESDDAATHVAAMARDREELVAKLHEANIPARPVDTGTYNAEHAYGSADTAISYVEQLREIGVDEVMCLIQMGTVPQEACMETIRQWGEKVIPHFRTLEAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K0R9</accession>
    <name>A0A2M9K0R9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Chorismate mutase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_06775</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000002">
        <property type="protein sequence ID" value="PJN12714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN12714">
        <property type="protein sequence ID" value="PJN12714"/>
        <property type="gene ID" value="CG723_06775"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004106">
        <property type="term" value="F:chorismate mutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046417">
        <property type="term" value="P:chorismate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.59.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036263">
        <property type="entry name" value="Chorismate_II_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010951">
        <property type="entry name" value="CM_bact"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036979">
        <property type="entry name" value="CM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002701">
        <property type="entry name" value="CM_II_prokaryot"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01817">
        <property type="entry name" value="CM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00830">
        <property type="entry name" value="CM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48600">
        <property type="entry name" value="SSF48600"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01795">
        <property type="entry name" value="CM_mono_cladeE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51168">
        <property type="entry name" value="CHORISMATE_MUT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Chorismate mutase" evidence="1">
        <location>
            <begin position="12"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN12714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="111" mass="12107" checksum="8C4A7968149221DE" modified="2018-04-25" version="1">MTNSNAADTVDPAVRAELARLRDSIDNIDAAVVHMLAERFKCTQQVGHLKAEHALPPADPSREASQIARLRQLAESAKLDPAFAEKLLNFIISEVIRHHEQIAANSSPCGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K198</accession>
    <name>A0A2M9K198_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Amidohydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_07865</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000002">
        <property type="protein sequence ID" value="PJN12913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN12913">
        <property type="protein sequence ID" value="PJN12913"/>
        <property type="gene ID" value="CG723_07865"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016831">
        <property type="term" value="F:carboxy-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032465">
        <property type="entry name" value="ACMSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21240">
        <property type="entry name" value="PTHR21240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04909">
        <property type="entry name" value="Amidohydro_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydro-rel" evidence="2">
        <location>
            <begin position="44"/>
            <end position="364"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN12913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="408" mass="44540" checksum="CAD97A54485A687F" modified="2018-04-25" version="1">MSERYTVISADCHAGADLLDYRPYLESRHHDAFDAWAASYVNPYADLLADTADRNWNSDRRIAELEQDGIVAEVVFPNTIPPFFPSASLMAPAPTREEFTRRWAGLRAHNRWLADFCAAAPGRRAGVFQILLNDVDEAVKEIRWAAAAGLKGGLLLPGTPPGSGLPELYSAAYDPIWATCAELGVPVNHHAGSASPPLGDEPAARAVFMVETTWFSHRALWHLVFGGAFRRHPGLKLVLTEQGSGWIPGVLDMLDYYHGRLVAAATRANTAESKFGAGLADSMGKGPSEVWRENCYVGASFMRPHEVPLRDRIGLDKIMWGSDYPHDEGTYPYTREGLRIAYAGLPRDEIAAMVGGNTARVYGFDLGLLDPIAARVGPTVQELGEPLDEAPKDATSPVFARGGSVRIW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K2U1</accession>
    <name>A0A2M9K2U1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Ribose ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CG723_02400</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CB01635</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000001">
        <property type="protein sequence ID" value="PJN13442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN13442">
        <property type="protein sequence ID" value="PJN13442"/>
        <property type="gene ID" value="CG723_02400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001851">
        <property type="entry name" value="ABC_transp_permease"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02653">
        <property type="entry name" value="BPD_transp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="31"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="60"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="110"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="138"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="181"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="277"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="322"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PJN13442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="349" mass="36804" checksum="AA95C451573F260F" modified="2018-04-25" version="1">MSAAAPGTPPLTDERLLKTSPLRKLMGRPELGSVVGAIAVFLFFAIFADSFLRASSLATVLYASSTIGIMAVPVALLMIGGEFDLSAGVMVTTSALISSMFSYQMTANVWVGVGVSLLFTLAIGVFNGVMLTRTDPPSFIITLGTFLMLTGMNLGFTKLISGTVSTKSISDMEGFSSAKDVFASTLTVGGVDFKITILWWLALIVVATWILLRTRVGNWIYAVGGGEDAARAVGVPVNKTKIGLYMGVAFGAWISGQHLLFSFEVVQSGEGVGNELIYIIAAVIGGCLITGGYGSAVGAAIGALIFGMTSKGIVFAEWNPDWFKFFLGAMLLLATLLNAWVRKRAEATK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K3A5</accession>
    <name>A0A2M9K3A5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Sugar ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CG723_03090</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000001">
        <property type="protein sequence ID" value="PJN13560.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN13560">
        <property type="protein sequence ID" value="PJN13560"/>
        <property type="gene ID" value="CG723_03090"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="8"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="259"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="40"/>
            <end position="47"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PJN13560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="506" mass="53869" checksum="9809C21D2876E3A1" modified="2018-04-25" version="1">MAPEPPLLTMSGITKSFPGVRALDGVDLEVLAGEVHCLLGQNGAGKSTLIKVLAGAHQPDDGTITWRGERTVLKSPIAAMRLGIATIYQELDLVEGLSVAENVYLGHEPTTAGFVVRGRDARTTTAALLKRLGHDEIGPGTLVGDLSAAQQQIVSMARALSHDVRLIVMDEPSAALDPDEVDNLFRIVDSLTADGVAVVYISHRLEEIRRIGDRVTVLKDGRAVAGGLPAKETPTRDVVALMTGRNVEYVFPERPSGPPRAEPVLTVKGLSRQGEFAPLDLELRPGEIVGLAGLVGSGRSEILETIYGARKASTGQVAVDGKVLRPGSVRAAVRAGLGLAPEERKAQALLMLESVTNNVSVSSMSRFSYGGWLDRGKELDAARAATRELSLRPDNPSAPVRTLSGGNQQKAVLARWLLRGCRVLLLDEPTRGVDVGARAELYAVIRRLADDGLAVLMVSSEVPEVLGLADRVLVLREGAVVHESPATELDEHRVLDLVLAGAQERP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-09-29" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K3B7</accession>
    <name>A0A2M9K3B7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Scramblase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_03395</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000001">
        <property type="protein sequence ID" value="PJN13612.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN13612">
        <property type="protein sequence ID" value="PJN13612"/>
        <property type="gene ID" value="CG723_03395"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017128">
        <property type="term" value="F:phospholipid scramblase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018929">
        <property type="entry name" value="DUF2510"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038595">
        <property type="entry name" value="LOR_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005552">
        <property type="entry name" value="Scramblase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025659">
        <property type="entry name" value="Tubby-like_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23248">
        <property type="entry name" value="PTHR23248"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10708">
        <property type="entry name" value="DUF2510"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03803">
        <property type="entry name" value="Scramblase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54518">
        <property type="entry name" value="SSF54518"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF2510" evidence="2">
        <location>
            <begin position="9"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="27"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN13612.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="310" mass="34271" checksum="B00BDFD6FEFA5ADA" modified="2018-04-25" version="1">MTTHSNTPAGWYPDPQGAPQTLRWWDGAQWTEHTSPVQQPAGQQVPQQAQRQPQQQQVQQPVQGQFAQQQQQHAAGPYGQQAPQQQSHVDPAKVQRQVQHQAGVAPTAQGGGSLFTEPVLVVNQKAKLIELTNEYTVMDQNGAQIGSVVQVGQSTLKKVARFVSSLDQFMTHKLEIRDAYGQPQLVMTRPAKFMKSRVVVERPDGSPVGEIVQQNMIGKINFGINVNGQQIGAIKAENWRAWNFSIVDHADNEVARITKTWEGLAKTMFTTADNYVLQIHYQLPEPLLSLVVATALTVDTALKQDARGFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JEX6</accession>
    <name>A0A2M9JEX6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CG723_44655</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000048">
        <property type="protein sequence ID" value="PJN05445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN05445">
        <property type="protein sequence ID" value="PJN05445"/>
        <property type="gene ID" value="CG723_44655"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PJN05445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="118" mass="13167" checksum="BBCFD73E46F2340C" modified="2018-04-25" version="1">MTDTGSISDGFHTFDELYEFRLLYHAHAVRAWLAARYPVVRSWKHHDGEPCFGGGWFIVMAQLPTGQVSNHYRANSWSLFGDVPEVETAPVWDGHSTTDVARRLRTLLSGDGSTSVAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JG24</accession>
    <name>A0A2M9JG24_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PrsW family intramembrane metalloprotease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_42655</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000040">
        <property type="protein sequence ID" value="PJN05836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN05836">
        <property type="protein sequence ID" value="PJN05836"/>
        <property type="gene ID" value="CG723_42655"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026898">
        <property type="entry name" value="PrsW"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36844">
        <property type="entry name" value="PTHR36844"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13367">
        <property type="entry name" value="PrsW-protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="63"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="99"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="173"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="224"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="253"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="282"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN05836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="453" mass="48756" checksum="F504E0A9D05250D6" modified="2018-04-25" version="1">MATYPPYPNAFPHAQPGAGAPGSGTLRHPRWWERKAVHAWALVSLLTLSGLVILALVREQTGTKGFLVGLCLAVLPVPLLIAAFRWLDRVAPGPWRNLLFSFAWGACAAALIAIVANSFATHWIATNSADPANADTLGATVIAPIVEESAKACAVLLIFLFRRRDFTGIVDGVVIAGVTATGFAFTENILYLGNAFGTDQLNSGTGIASVTAATFFVRIVMSPFAHPLFTVLTGIGFGVAAWTAPDRGPVRRVFLPLAGLLLAMGMHATWNGSSAFGRFGFFGVYALFMMPAFGLLTWLAIGTRQRELRRVRSELPAYAAAGWVGPAEPFALGSMRARRLAREFAQHHGGKATAKAVAQYQQYATSLALLRHRGRRGRAGADYVVRERELLDELWARRHAARPALAYASRATAPPVWVPPMYAGPVHAGPVHAGPVAQFPAHSAHNAYNPYRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JGE0</accession>
    <name>A0A2M9JGE0_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF4395 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_41610</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000037">
        <property type="protein sequence ID" value="PJN05946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN05946">
        <property type="protein sequence ID" value="PJN05946"/>
        <property type="gene ID" value="CG723_41610"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025508">
        <property type="entry name" value="DUF4395"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14340">
        <property type="entry name" value="DUF4395"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="77"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="102"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4395" evidence="2">
        <location>
            <begin position="3"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN05946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="138" mass="14504" checksum="5020196039278DB3" modified="2018-04-25" version="1">MDIDVRGPRFGAAVTTVVLALVLVTGSAWLLAWQTLCFALGAAGGVGRSPYAWLFRTAVRPRIGPPTEFEAPQPPRFAQFVGLVFAAVGLVGLVWGPGWLGLAATACALAAAFLNSAFGYCLGCEMYLLLRRGAARFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JGV9</accession>
    <name>A0A2M9JGV9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">IS3 family transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_40990</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000035">
        <property type="protein sequence ID" value="PJN06120.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN06120">
        <property type="protein sequence ID" value="PJN06120"/>
        <property type="gene ID" value="CG723_40990"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025948">
        <property type="entry name" value="HTH-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13276">
        <property type="entry name" value="HTH_21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13333">
        <property type="entry name" value="rve_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="1">
        <location>
            <begin position="121"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN06120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="290" mass="32453" checksum="D8F6AB39AE92670E" modified="2018-04-25" version="1">MTVHPFIEAEKQDGHNVKRACELLKVSRTAFYARRSSKPGPRAVQDAELTQQITSVHERSRGTYGAPRVHAVLKQEGAGCGRRRVARLMRAAGLEGRHRRRRHLTTIPDPRAALRPDLVVRNFAPDASGRDTRWCGDITYVPTEEGWLYLATVIDIASRRVVGWATADHLRTGLVADALRSACRQRRPDHPVIFHSDRGCQYTSQQFAALADELGVRLSVGRTGQCWDNALAESFFATIKRELLGIAAWPSRASARTAIFDFIEGWYNLHRLHSSLGYRSPADYETALAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JH05</accession>
    <name>A0A2M9JH05_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_41055</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000035">
        <property type="protein sequence ID" value="PJN06133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN06133">
        <property type="protein sequence ID" value="PJN06133"/>
        <property type="gene ID" value="CG723_41055"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026001">
        <property type="entry name" value="Abi-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041427">
        <property type="entry name" value="AbiJ-NTD3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14355">
        <property type="entry name" value="Abi_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18860">
        <property type="entry name" value="AbiJ_NTD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AbiJ_NTD3" evidence="2">
        <location>
            <begin position="6"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="domain" description="Abi_C" evidence="1">
        <location>
            <begin position="216"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF18860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN06133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="311" mass="34992" checksum="42F0F1B56B24B63A" modified="2018-04-25" version="1">MAPQQLTVVTRQRLLDLLVVEKIWWWGALDEVRFLERLYDLDTLEGDGYRRLTAREDIWQHCINNDDWLPEWVFTDARFGLSGPSPQPLLNFLAEMLHPVVRRDPAEVERLAEKLNGILTKDGFELYPTGYISGLPVYAGGPRASFHGARPDLKFEARPLLTDPRVLHEHQERIRAGLERDPAAAIASCKELVESLCKIILEHQDIEFPPGEDLPPLFKRVTTLLGLNADAVADHAKASATVVKILRTLTTTVQGLAELRNQLGLGHGRTAPSPALTRHARLALNSTVTVTEFVLDTWQDRIERGKLSPRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JHD1</accession>
    <name>A0A2M9JHD1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_40410</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000033">
        <property type="protein sequence ID" value="PJN06281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN06281">
        <property type="protein sequence ID" value="PJN06281"/>
        <property type="gene ID" value="CG723_40410"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039448">
        <property type="entry name" value="Beta_helix"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006626">
        <property type="entry name" value="PbH1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13229">
        <property type="entry name" value="Beta_helix"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00710">
        <property type="entry name" value="PbH1"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="SSF51126"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014760764" evidence="1">
        <location>
            <begin position="23"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="domain" description="Beta_helix" evidence="2">
        <location>
            <begin position="68"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="domain" description="Beta_helix" evidence="2">
        <location>
            <begin position="244"/>
            <end position="349"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN06281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="354" mass="36805" checksum="056226B968962FEE" modified="2018-04-25" version="1">MTKRQIAYLACTAAVVVSGVGAAAPSADCRTVVHRVNPGESIQKAVNTAKPGDVIFLSPGTYHESVSITVSGLTLRGASARSTVIVPAAASAAGTCAKAGNGICVTGTKTKPVEHVTVRSLTLRGFKKNGLLATGTDRLRVEGVTSEKNGQWGIAQERSVRGVFRHDTVEANGDAGLFLANTIDAEEGAPNSRAVISNNRLVGNRIGVTVRRLRNVTVDHNEATGNCAAMMLVGDENKPRPGALKVRNNYVHDNNKYCAATARLPFLQGSGIVLTGVEDSLVAGNSIEDNVGKAPMSGGIVLAKNFKGALNQRNEIRDNLVMGNGTADLASQDKGKGNTFRGNTCAVSVPAGMC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JHT5</accession>
    <name>A0A2M9JHT5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CG723_39045</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000030">
        <property type="protein sequence ID" value="PJN06413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN06413">
        <property type="protein sequence ID" value="PJN06413"/>
        <property type="gene ID" value="CG723_39045"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PJN06413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="64" mass="6698" checksum="7CCE605A65D5219B" modified="2018-04-25" version="1">MLPGAVQLAALTVAAHTRPDGTTSADLDLLIHLCGPTPQQLTDLLDQLAGSQLPASWHQEGEVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JHU1</accession>
    <name>A0A2M9JHU1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Haloacid dehalogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CG723_39370</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000030">
        <property type="protein sequence ID" value="PJN06456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN06456">
        <property type="protein sequence ID" value="PJN06456"/>
        <property type="gene ID" value="CG723_39370"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023198">
        <property type="entry name" value="PGP-like_dom2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PJN06456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="215" mass="22731" checksum="F3E06616B8892D6C" modified="2018-04-25" version="1">MAAHSPTVGFDLDMTLIDSRPGIKALYQELSARTGTFIDADLAASRLGPPLEEEIRHWFPEERVADTAALFRELYPQYAVAATPALPGAREAIDAIHAAGGRAIVVTAKYEPNAKLHLEHLGLDVDALFGSLWAEGKAEALRKHHAQVYVGDHIGDVVGAHTAGALSVAVATGPCDATELRNAGAEVVLAELTEFPSWLERYVAEGVDGGDGAAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JHU3</accession>
    <name>A0A2M9JHU3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CG723_39285</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000030">
        <property type="protein sequence ID" value="PJN06444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN06444">
        <property type="protein sequence ID" value="PJN06444"/>
        <property type="gene ID" value="CG723_39285"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.490.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018727">
        <property type="entry name" value="DUF2267"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038282">
        <property type="entry name" value="DUF2267_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10025">
        <property type="entry name" value="DUF2267"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PJN06444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="145" mass="15845" checksum="065C2F017B921D8D" modified="2018-04-25" version="1">MISDLRTPLQQLPAMTYEQMLEKVRYEGAYPTRERAEEATHLVLEGLGRQLTGDERVELAARLPFEAARVLTTQIPDTPPLTGWAFVKDLADRTGASLATTRWNTGAVFAAVAALAGPDLLTRILRQLPSGFALLFGRAELIPAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JI29</accession>
    <name>A0A2M9JI29_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Serine hydroxymethyltransferase</fullName>
            <shortName evidence="7">SHMT</shortName>
            <shortName evidence="7">Serine methylase</shortName>
            <ecNumber evidence="7">2.1.2.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">glyA</name>
        <name evidence="10" type="ORF">CG723_38840</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CB01635</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + glycine + H2O = (6S)-5,6,7,8-tetrahydrofolate + L-serine</text>
            <dbReference type="Rhea" id="RHEA:15481"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15636"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="EC" id="2.1.2.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 7 8">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2 7">Amino-acid biosynthesis; glycine biosynthesis; glycine from L-serine: step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="7">One-carbon metabolism; tetrahydrofolate interconversion.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the SHMT family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.2.1" evidence="7"/>
    <dbReference type="EMBL" id="NNBL01000029">
        <property type="protein sequence ID" value="PJN06502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN06502">
        <property type="protein sequence ID" value="PJN06502"/>
        <property type="gene ID" value="CG723_38840"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00193"/>
    <dbReference type="UniPathway" id="UPA00288">
        <property type="reaction ID" value="UER01023"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004372">
        <property type="term" value="F:glycine hydroxymethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019264">
        <property type="term" value="P:glycine biosynthetic process from serine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035999">
        <property type="term" value="P:tetrahydrofolate interconversion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00378">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00051">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001085">
        <property type="entry name" value="Ser_HO-MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019798">
        <property type="entry name" value="Ser_HO-MeTrfase_PLP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039429">
        <property type="entry name" value="SHMT-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11680">
        <property type="entry name" value="PTHR11680"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00464">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000412">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00096">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4 7" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="6 7 8" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SHMT" evidence="9">
        <location>
            <begin position="8"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="7">
        <location>
            <begin position="125"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="35"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="55"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="57"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="64"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="65"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="121"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="175"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="203"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="228"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="235"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="365"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="7 8">
        <location>
            <position position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000412-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PJN06502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="419" mass="45101" checksum="4B374A496FFD4FA8" modified="2018-04-25" version="1">MSLMNTSLHELDPDVAAAVDAELLRQQSTLEMIASENFAPVAVMEAQGSVLTNKYAEGYPGRRYYGGCEHVDVTEQIAIDRVKDLFGAEYANVQPHSGASANQAALFALAKPGDTILGLDLAHGGHLTHGMRLNFSGKQFDVVAYHVDEAGLVDMAEVERLAKEHRPKVIIAGWSAYPRQLDFAAFRRIADETGAYLWVDMAHFAGLVAAGLHPNPVEYADVVTSTTHKTLGGPRGGIILAKKDFAKKLNSSVFPGFQGGPLEHVIAAKAVSFKVAASEDFKERQQRTIEGAQILAARLTSDDARATGVNVLSGGTDVHLVLVDLRESELDGQQAEDRLHEVGITVNRNAVPNDPRPPMVTSGLRIGTPALATRGFQAEDFTEVADIIAEALKPEYDAVSLKARVTALADKFPLYPGLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JIC5</accession>
    <name>A0A2M9JIC5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cupin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_37740</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000027">
        <property type="protein sequence ID" value="PJN06631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN06631">
        <property type="protein sequence ID" value="PJN06631"/>
        <property type="gene ID" value="CG723_37740"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013096">
        <property type="entry name" value="Cupin_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07883">
        <property type="entry name" value="Cupin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cupin_2" evidence="1">
        <location>
            <begin position="37"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN06631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="124" mass="12888" checksum="1398495157AAF778" modified="2018-04-25" version="1">MPVVRASDAVVHEMHGVRFVSYAKPAAGSKELCAWRAEIPAGTPGVAHTVSREEILHVLSGSLRFTVDGRTDTLAAGDTAIVNPGATLTVENPGDSPAAMWVTTSAGLEAVLADGTRLTPPWAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JII4</accession>
    <name>A0A2M9JII4_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 9">Gluconokinase</fullName>
            <ecNumber evidence="4 9">2.7.1.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CG723_38105</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CB01635</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>ATP + D-gluconate = 6-phospho-D-gluconate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19433"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:18391"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58759"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.12"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Carbohydrate acid metabolism.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the gluconokinase GntK/GntV family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.12" evidence="4 9"/>
    <dbReference type="EMBL" id="NNBL01000027">
        <property type="protein sequence ID" value="PJN06689.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN06689">
        <property type="protein sequence ID" value="PJN06689"/>
        <property type="gene ID" value="CG723_38105"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00705"/>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046316">
        <property type="term" value="F:gluconokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02021">
        <property type="entry name" value="GntK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031322">
        <property type="entry name" value="Shikimate/glucono_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006001">
        <property type="entry name" value="Therm_gnt_kin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43442">
        <property type="entry name" value="PTHR43442"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01202">
        <property type="entry name" value="SKI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01313">
        <property type="entry name" value="therm_gnt_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 9 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="6 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU363066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PJN06689.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="181" mass="19330" checksum="EA5EF369E6AC936E" modified="2018-04-25" version="1">MKTRRTPHVVVVMGVAGTGKTTIGPLLADRLGVPYAEGDDFHPPANIAKMSAGTPLTDDDRWPWLDAIGEWAHGRAGLGGVVSSSALKRSYRDRLRAEAPGVVFVHLTGDRALIEDRMSHRQGHFMPTALLDSQFATLQPLAADEAGVDVDVSGSPEEITERAVAALDSLEGRSPSPSARR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JIU5</accession>
    <name>A0A2M9JIU5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Histidine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CG723_37615</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000026">
        <property type="protein sequence ID" value="PJN06794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN06794">
        <property type="protein sequence ID" value="PJN06794"/>
        <property type="gene ID" value="CG723_37615"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025828">
        <property type="entry name" value="Put_sensor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011712">
        <property type="entry name" value="Sig_transdc_His_kin_sub3_dim/P"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07730">
        <property type="entry name" value="HisKA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13796">
        <property type="entry name" value="Sensor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="30"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="54"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="131"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="domain" description="Sensor" evidence="3">
        <location>
            <begin position="32"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="domain" description="HisKA_3" evidence="2">
        <location>
            <begin position="200"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PJN06794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="392" mass="42084" checksum="CA7809B9B503A5CC" modified="2018-04-25" version="1">MTARIVTTEPDVDRPPAPRFAFDRHTWKEIAYLLSNLPVAVLGFAYVVTMLATGVGLAVTVIGLPVLAAGLLGARQLGKAERGRARALLGLRIEEPSPLPRRRDEGFFGRLWSGLKDPVGWRAMLYEFIRLPWGVLTFAITLTGLFVLWPVLPFIVRGLTNADRAMARALLSPSDELERRIAELESDRGVVVDTAAADLRRIERDLHDGAQARLVNLAMGLGLAKEKLLEDPDAAAAMVDEAHGEVKLALQELRDLARGIHPAVLTDRGLDAALSSVASRCTVPVKVTADLPQRPAAAIEGIAYFTVSELLQNVSKHSGARSASVDVWRSGDRLLIQVGDDGHGGASLDKGTGMSGLADRLGAVDGLFVVDSPEGGPTTVTAELPWRDRTPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JJC0</accession>
    <name>A0A2M9JJC0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_36340</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000024">
        <property type="protein sequence ID" value="PJN06963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN06963">
        <property type="protein sequence ID" value="PJN06963"/>
        <property type="gene ID" value="CG723_36340"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041413">
        <property type="entry name" value="MLTR_LBD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17765">
        <property type="entry name" value="MLTR_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="14"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN06963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="266" mass="29895" checksum="32B8AD9449507DC3" modified="2018-04-25" version="1">MSETAERRRELGAFLRSRRARITPVQAGLPSTGRRRTPGLRREELALLAGMSATWYTYLEQGREIRASDQVLDALATALRLAPHEREHLFQLAGRAPAADIPDVEPLAPEVAAVPLLLQPHPAYVIDGTYDVLSLNGATEEVFPRLVAEDGRRPNFVRWVFLEPLAREVLVDWEPEARGLLARVRTLAGGHPGDPRYARLVDELHEGSPEVRDWWPRFEVEARRGGRKRLRSPGRGVVTYDYTAFHVAGQPERTLVIYAETSGSRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JJZ0</accession>
    <name>A0A2M9JJZ0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Translation initiation factor IF-2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CG723_34915</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000022">
        <property type="protein sequence ID" value="PJN07186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN07186">
        <property type="protein sequence ID" value="PJN07186"/>
        <property type="gene ID" value="CG723_34915"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006764">
        <property type="entry name" value="SAM_dep_MeTrfase_SAV2177_type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04672">
        <property type="entry name" value="Methyltransf_19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017393">
        <property type="entry name" value="MTase_SAV2177"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="1" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PJN07186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="268" mass="28843" checksum="C50B351475F91662" modified="2018-04-25" version="1">MSEQSGQEPGERTTSHIAHNARVWNYWLGGKDHYEVDQQVGDQVTSMYPSIGEVARADRAFLGRAVTYLAGRAGIRQYLDIGTGLPTAENTHEVAQRIAPDSRVVYVDNDPIVLTHARALLTSTDEGATSYVDADAHDPAAILRAASGTLDLGRPVAVMMLGILNFILDTAEATSIVRHLVDAVPSGSYLVVTHPTLELGGEGNEEAMRFWNENATPPITARGRAEVEGFLDGLDVLEPGLVSCARWRTDGADEGPIVAQFGVLARKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JK14</accession>
    <name>A0A2M9JK14_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">ATP-binding cassette family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CG723_35010</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000022">
        <property type="protein sequence ID" value="PJN07202.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN07202">
        <property type="protein sequence ID" value="PJN07202"/>
        <property type="gene ID" value="CG723_35010"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038729">
        <property type="entry name" value="Rad50/SbcC_AAA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13476">
        <property type="entry name" value="AAA_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA_23" evidence="3">
        <location>
            <begin position="5"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="339"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="457"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="290"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="339"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="460"/>
            <end position="480"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13476"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PJN07202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="998" mass="107257" checksum="5C75997DB78898A0" modified="2018-04-25" version="1">MRLHRLRITAFGPFGASQEVDFDDLSSAGLFLLHGPTGAGKTSVLDAVCYALYGSVPGARQGGGQGTSLRSDHAAPGTRTEVALDLTVAGRRLELTRQPPWERPKKRGTGTTTDKAQSWLREYDATAGTWKDLSRSHQEIGEEISQLLGMSKEQFCQVVLLPQGDFARFLRADAEARGKLLGRLFDTRRFAAAEQRLAERRRAAESEVRAADAELLADAHRMQQAAGNIVELPATDAAPGDPGLADSVLTWAAVARSTIRERLTVAHLALTAADAARTEAQRDLAGVQEVQRLQRRFEEARERAARLDERADEHRRVQERMAWGRKAEAVAPALALREAAETEHRRATSEDTRARATLPDSYDGAGAAGLAAAARKTAEELGGLESARRAELRLTELAGQRHGLDRQERADDELLQDSASWLDGWDSARAALQAAVESAQDAATRAEHLVGQLEPAQQKLASARRRDRLTGEAADAQTRTLRAREEAAAAHERWLGLKEQRLNGIAAELAAQLVPGESCAVCGSTDHPDPMRKTAEHVGRDAEESALAAYRRADDARTAQESRLAAVRESLSAATAAAGEASAVELAEAADELRARHAEARGLASGLHAAREALGQAEGEHDRRLAAQQEAARRAVARATLREGVDREQGVLERELAQARGSEASVGARAVQLERLAAQLTAAADAARGADEAAKRLKDADARLADAAFRAGFDTPEAAGAALLDDAQHRELQHRLDARQFEEAAVRAVLAEDDTAAAARQAPADVAAALFAAEAADRRVREAASARDDAARRCTEIDRLSARCATAVRRLAPLRAAYDRVARMAGLAAGTSADNERKMRLESYVLAARLEQVAAAATARLARMSSGRYTLVHSDGRSGRGRSGLGLHVVDAWTGRERDTATLSGGETFFASLALALGLADVVTDEAGGVRLDTLFIDEGFGSLDDQTLDEVLDVLDSLRERDRSVGIVSHVADLRRRVHAQLEIVKGRSGSVVRQRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JL33</accession>
    <name>A0A2M9JL33_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">LysR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_32990</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LysR transcriptional regulatory family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000019">
        <property type="protein sequence ID" value="PJN07584.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN07584">
        <property type="protein sequence ID" value="PJN07584"/>
        <property type="gene ID" value="CG723_32990"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005119">
        <property type="entry name" value="LysR_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000847">
        <property type="entry name" value="Tscrpt_reg_HTH_LysR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00126">
        <property type="entry name" value="HTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03466">
        <property type="entry name" value="LysR_substrate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00039">
        <property type="entry name" value="HTHLYSR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50931">
        <property type="entry name" value="HTH_LYSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH lysR-type" evidence="2">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN07584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="301" mass="32200" checksum="6C5B7603BFA1FF0B" modified="2018-04-25" version="1">MDLALLRTFVTVHRAGSFTRAAALLGLSQPAVTSQIRTLERQLGRPLFLRQARGVTPTSIGDELAHKAAPHLDALVEITETGIDEESPVRTLHLAGPPEFTAERALPALTALTRDDGQSFALRASFGNAEEVLEGLGAGHHDLAITTARPRGALLTATALCDEEHVLLASPRWAARIGPGTLRRSGAAALEDLPLVEAHESLPFVARYWAAVFDSRPATSGTVIVPDLRAVLACTIAGAGLSVLPRYLCAPALERGEVVALLDPPVPPLRTYFLVVRTGTLAMPHIARAHEWLLRTAVDWC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JLC6</accession>
    <name>A0A2M9JLC6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_32950</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000019">
        <property type="protein sequence ID" value="PJN07577.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN07577">
        <property type="protein sequence ID" value="PJN07577"/>
        <property type="gene ID" value="CG723_32950"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012507">
        <property type="entry name" value="YibE_F"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41771">
        <property type="entry name" value="PTHR41771"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07907">
        <property type="entry name" value="YibE_F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="42"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="181"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="205"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="231"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="261"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="303"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="357"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="402"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="95"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="428"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="97"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN07577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="450" mass="46451" checksum="286DF2FF8A27A4CD" modified="2018-04-25" version="1">MTSTPQPPSTPPQPPHGQGSAEHGHSHSHGPAAPVSKHLRKVIAAVLIPFSVAVVVGLVVLWPGGAPSHARTGVGFDRQTQQGTVTKVDKVDCKSVNASGDTPTGDTSTAEGQTAEQQAKGTCEKATVRVDTGKDTGRTFTEIVQPDSPRQLHEGQKVIVAYAPDAPKELQYSVTDVDRRLPMALLAGIFALAVVVVGRLRGVMALVALAISFMVLTFFILPAILQGSNPLVVAVIGASAIMLIALYLCHGLTARTSVAVLGTLVSLVLIGLLGSLFIGWAALTGNTDDNTGLIHGLYPSIDMSGLLLAGVIIGSLGVLDDVTVTQTSAVWELHQADPTMGWRGLYRAGIRIGRDHIASVVNTLVLAYAGAALPLLLLFSIAQSSVGTVANSELVAVEIVRTLVGSIGLVASVPVTTALAALVVSADRPGSPSAAAAGPARGGRGRRRKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JM67</accession>
    <name>A0A2M9JM67_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">TetR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_30135</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000016">
        <property type="protein sequence ID" value="PJN07963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN07963">
        <property type="protein sequence ID" value="PJN07963"/>
        <property type="gene ID" value="CG723_30135"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041467">
        <property type="entry name" value="Sco4008_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17926">
        <property type="entry name" value="TetR_C_21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="11"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="34"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN07963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="195" mass="22083" checksum="7A7E89B4CCF75B69" modified="2018-04-25" version="1">MADQPLTSRGAATYQRILDVATQEFAQHGIAGARIERIVSAARTNKAQLYAYFGNKEKLFDAIFFASLERITNVVPIDADDLADWAVRLYDEYLRRPDLIRLATWARLERRPVGHLVENHDHYDDRKLRAVAEAQAAGRVRQGDPFDVMAMVIAMSMAWSPVSNVYAATAQESPDLHEQRRTLLRDCVRRAVAVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JM80</accession>
    <name>A0A2M9JM80_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Multidrug ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CG723_30195</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000016">
        <property type="protein sequence ID" value="PJN07974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN07974">
        <property type="protein sequence ID" value="PJN07974"/>
        <property type="gene ID" value="CG723_30195"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="2"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="34"/>
            <end position="41"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PJN07974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="312" mass="32830" checksum="5BFC2A90D1B3A772" modified="2018-04-25" version="1">MIDAQQLTKRYGEKTAVDGLDFTVKPGTVTGFLGPNGAGKSTTMRMVIGLDAPTRGSVTVNGHRYARHQAPLQEVGALLEAKSIHPGRSASNHLRALALTHGIPRRRVDEVIELAGLGTVAKKRAGAFSLGMGQRLGIAAALLGDPQTVMLDEPVNGLDPEGVLWIRNLLTSLAAEGRTVFVSSHLMSEVALVADHLIIVGRGQLLADTTVRDLVREAGGDTVKVATQDPATLRDVLSGPGVDVTGRVGSEELQVTGMTAREIGLMAAEHGIPLFELTAKAVSLEEAFMELTRDAVEYHGSTTGADTFGSTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JMG9</accession>
    <name>A0A2M9JMG9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ornithine decarboxylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CG723_30705</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CB01635</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Orn/Lys/Arg decarboxylase class-I family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000016">
        <property type="protein sequence ID" value="PJN08054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08054">
        <property type="protein sequence ID" value="PJN08054"/>
        <property type="gene ID" value="CG723_30705"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00615">
        <property type="entry name" value="Orn_deC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000310">
        <property type="entry name" value="Orn/Lys/Arg_deCO2ase_major_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008286">
        <property type="entry name" value="Prn/Lys/Arg_de-COase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01276">
        <property type="entry name" value="OKR_DC_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03711">
        <property type="entry name" value="OKR_DC_1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OKR_DC_1" evidence="3">
        <location>
            <begin position="299"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="domain" description="OKR_DC_1" evidence="3">
        <location>
            <begin position="569"/>
            <end position="754"/>
        </location>
    </feature>
    <feature type="domain" description="OKR_DC_1_C" evidence="4">
        <location>
            <begin position="850"/>
            <end position="885"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="105"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF03711"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PJN08054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="922" mass="102555" checksum="4F7F4D10A35B1DF1" modified="2018-04-25" version="1">MGDTPANPPAGASGSPVAGVYSSVRQLRADAWSSLTELARQWASDTSGAAHRQSTQELLDGLFRQLLPIENCWAFPGKTAFAELRRLRTAEDRYGLARRTDELHRALGTESYRGATPRPAEPTAPAGEEPLPGGTTPKPYFEVLVVGELTAAEEEALRVSLRGRRRAEDEFVYEIVVAPSFEDAAMAVLVNPGLQAVVIHRRFADRSPYDLSVVAGLVEQPPVDPYAQDGPYEQRAQALGARLLELRPEIDLYLMTDGSVERIAGVLSSGFARVFHAREGLLELHLSILHGVRERFRAPFFTALRAHSRRPTGVFHALPISRGTSLLTSHWIPEMVEFYGLNIFLAETSATSGGLDSLLEPTGPLREAQDLAARTFGARQSYFVTNGTSTANKVVVQALVRPGDIVLVDRNCHKSHHYGLMLAGAQVVYLDAYPLDRYGMYGAVPVKEIKRKLLELRRAGLLDRVKMLMLTNCTFDGIVYNPTRVMEECLALKPDLAFLWDEAWFAFARFHPVYRRRTAMAAARTLTASLRGQDLADRYALQQRELGDDPDDETLLDHRLVPDPAKARVRVYATQSTHKTLTSLRQGSMIHVFDQDFSHRTAETFREAYMTHTSTSPNYQILASLDLGRRQAALEGFELVQKQLEQAGVLRDAIDQHPVLSRYLRFLTTPDLIPGEFRASGVEQPLRTGLARMSAAWEDDEFVLDPTRATLHIGLTGIDGDTFKHEYLMDRYGVQVNKSTRNTLLFMTNIGTTRSAVAYLIEVLLKIVEELEDRKDELGPPALRRPDADAVRDTVVALPDFSAFHAAFRPGGRTPEGDIRRAFYLAYDETQCEYLSADEVREGMAGGRDVVSATFVTPYPPGFPVLVPGQVVNEAVLDYMRALDTREIHGYRPETGYRVFTEQALKEQQTLLESGNGPWAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JMM4</accession>
    <name>A0A2M9JMM4_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">YCII domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_30850</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the YciI family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000016">
        <property type="protein sequence ID" value="PJN08112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08112">
        <property type="protein sequence ID" value="PJN08112"/>
        <property type="gene ID" value="CG723_30850"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005545">
        <property type="entry name" value="YCII"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03795">
        <property type="entry name" value="YCII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YCII" evidence="2">
        <location>
            <begin position="17"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007689"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN08112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="135" mass="15106" checksum="70F72363221741CC" modified="2018-04-25" version="1">MAKYLLLKHYRGAPASVNDVPMAQWTPEEISAHVQYMQDFKDRLEKTGEFVDSQALAPEGTWVRYDGEGRPPVTDGPFAETKDLIAGWMVIDVDSYERAVELAGELSAEPGAGGKPIHEWLELRPFMGSQHTIME</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-09-29" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JMS2</accession>
    <name>A0A2M9JMS2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_29555</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000015">
        <property type="protein sequence ID" value="PJN08154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08154">
        <property type="protein sequence ID" value="PJN08154"/>
        <property type="gene ID" value="CG723_29555"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015209">
        <property type="term" value="F:cytosine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030191">
        <property type="entry name" value="CodB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30569">
        <property type="entry name" value="PTHR30569"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="47"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="77"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="111"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="148"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="181"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="220"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="261"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="310"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="360"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="388"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="427"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="456"/>
            <end position="476"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN08154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="561" mass="59898" checksum="A756C029B282C63D" modified="2018-04-25" version="1">MTDTVTRDTEAAAPRRSYAKLAADESREDFSLRYAPHSYRRWSPTMVASTALGGIAYLADFAIGASIVFTYGFTSGLASILCAATIIFLTGIPIARACAKYGLDMDLITRGAGFGYFGSTLTSLIYASFTFIFFALEGSIMAQAMHEVVGLPLPVGYLLTTLIVIPIVFRGMGALAKVQAWTQPVWLIGLVLPFVILAFHSPGSFGDFTHFGGTEGAGSGFSWLGFGLGTGVALSLIAQIGEQADYLRFMPAKTEQNRKRWNLAVLAAGPGWVIIGAAKQLGGALLAFVALEAVGKTHALEPIAPQVEALKPWLGSVALPAAALFVVVSQIKINVTNAYSGSLSWSNFFSRITHRHPGRVWYIFLNLAIALTLMEMNMFAALNKLLGFYSNVGIAWIAAVAADLVINKRVGWSPKYIEFKRAYLYAVNPAGFGAMVIASTVSIVAFFGVFGAYAEAFSTFIAAGLALTLCPLIAWATKGKYYLARPNPVNGPDVEIADITATHTCSVCETAYELPDIADCPVRSGPICSLCCSLDAECGDVCRKEPQAGPVLMPMPTVRTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JMU9</accession>
    <name>A0A2M9JMU9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Peptide ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CG723_29665</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CB01635</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000015">
        <property type="protein sequence ID" value="PJN08175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08175">
        <property type="protein sequence ID" value="PJN08175"/>
        <property type="gene ID" value="CG723_29665"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025966">
        <property type="entry name" value="OppC_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12911">
        <property type="entry name" value="OppC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="79"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="144"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="179"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="254"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="312"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="7">
        <location>
            <begin position="140"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PJN08175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="342" mass="35511" checksum="B0631A4A50BB2B0E" modified="2018-04-25" version="1">MPEPEPPEPYLSGGGRVPEDGGAIAATGAGGAMDLATSEGTTLEQQPSAASGGRAPGGPEGKPRSLWSDAWRDLRRNPIFIISGLIIVFLVIISIWPSLIASGNPLSCDLAKAQEGSQPGHPFGFNGQGCDVYTRTVYGARTSVTVGVCATVGVALLGSVLGGLAGFFGGGWDAILSRITDVFFAIPVVLGGLVLLSVVTSSTVWPVIGFMVLLGWPQLSRIARGSVITAKQNDYVQAARALGASNSRMMLRHILPNAIAPVIVVATIALGTYISLEATLSYLGVGLKPPTVSWGIDISSASQYIRNAPHMLLWPAGALAITVLAFIMLGDAVRDALDPKLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JN10</accession>
    <name>A0A2M9JN10_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Serine hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_29650</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000015">
        <property type="protein sequence ID" value="PJN08262.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08262">
        <property type="protein sequence ID" value="PJN08262"/>
        <property type="gene ID" value="CG723_29650"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001466">
        <property type="entry name" value="Beta-lactam-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00144">
        <property type="entry name" value="Beta-lactamase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Beta-lactamase" evidence="1">
        <location>
            <begin position="24"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN08262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="450" mass="46982" checksum="10BEC071C47E44CD" modified="2018-04-25" version="1">MIQERAGEREGPHMLDDLEVRCAEAMAGYGCPSVSVAVAVRGEVIRAEAYGLADTGARIPATVRTPYALASVTKPVTAAAVCVAADEGVLDLDAPGPLGATPRQLLRHRGGLGAHYDFHYGEEGEPAIDAEPYTRLQRAPGSGFEYANLGYRLLGRHLEDATGQDLATYARERVLGPLGLDGFRIATHCPGAATRYTPDGRPYPQGLRTSHPGATLGWATASQLALFAQSWPRLLKPETAAAVLDAVPIGEHLGYGLGWCVSRGEGPLLVSHGGGMGGVAVMAVSAPEPGLSVAVLTNTTAKAARDAVVAHVLGELVPGFRPELISPVFSVPARPLTLQEGEWAGHASTPEGEVPLRLRILPGARAELATGDESATASVDATATLALRGSFPVQLPTADARVSGPVLGLELRLDEGRLTGVARVYKEGDREGLIGNLLTHPCELGLVRAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JNB0</accession>
    <name>A0A2M9JNB0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CG723_28615</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000014">
        <property type="protein sequence ID" value="PJN08351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08351">
        <property type="protein sequence ID" value="PJN08351"/>
        <property type="gene ID" value="CG723_28615"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008305">
        <property type="term" value="C:integrin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007155">
        <property type="term" value="P:cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.130">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013517">
        <property type="entry name" value="FG-GAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013519">
        <property type="entry name" value="Int_alpha_beta-p"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000413">
        <property type="entry name" value="Integrin_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028994">
        <property type="entry name" value="Integrin_alpha_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01839">
        <property type="entry name" value="FG-GAP"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13517">
        <property type="entry name" value="FG-GAP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01185">
        <property type="entry name" value="INTEGRINA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00191">
        <property type="entry name" value="Int_alpha"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69318">
        <property type="entry name" value="SSF69318"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51470">
        <property type="entry name" value="FG_GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014650729" evidence="4">
        <location>
            <begin position="42"/>
            <end position="504"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PJN08351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="504" mass="49070" checksum="86517FA6CA6757EC" modified="2018-04-25" version="1">MPKHKRTPAVRPGRGRIAAATAAAAALTGGLVSLSAGAASATPGASATQPHEADFNLDGYPDVAVSSPEASVGGHAKAGQITVFYGSANGISAAKRATLTQSSTGVPGTPESGDLFGYVTSPGDFNRDGFTDLAVGTPYEDMPGDTDGGTVTILWGSSGGLKGGTTITDPAPTSHDRFGFDVAAGDFDGDGKTDLVTADSSKSVRVFKSGIAKSGTVGSVTAVTTPVRATSPYHLRKLTAGDVNADGKDDLVVSGNNATSDGDYLANFYLPGTASGPSATATATALPGGVISDIGDINGDGFGDVVTGLTSDSSNSEGQPGTSTGGDIHVTYGSATGPDGGTTVISQDTAGVPGTGEASDLFGWEISVGDITGDGLSDIAVGTVAEDGAASGSGDSGAVTVLYGSASGVTGTGAQTFTQDTAGVPGTSEYKDAFGTDVLLSDFNADGRSDLAIGVGGENEGNGAVTVLKSSGGRITTTGAVSLSPSAVGVSTSGTPQFGSVFGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JNV9</accession>
    <name>A0A2M9JNV9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Diaminopimelate decarboxylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CG723_27625</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CB01635</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the Orn/Lys/Arg decarboxylase class-II family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000013">
        <property type="protein sequence ID" value="PJN08550.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08550">
        <property type="protein sequence ID" value="PJN08550"/>
        <property type="gene ID" value="CG723_27625"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008836">
        <property type="term" value="F:diaminopimelate decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009089">
        <property type="term" value="P:lysine biosynthetic process via diaminopimelate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06828">
        <property type="entry name" value="PLPDE_III_DapDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.37.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009006">
        <property type="entry name" value="Ala_racemase/Decarboxylase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002986">
        <property type="entry name" value="DAP_deCOOHase_LysA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022643">
        <property type="entry name" value="De-COase2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022644">
        <property type="entry name" value="De-COase2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000183">
        <property type="entry name" value="Orn/DAP/Arg_de-COase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029066">
        <property type="entry name" value="PLP-binding_barrel"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02784">
        <property type="entry name" value="Orn_Arg_deC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00278">
        <property type="entry name" value="Orn_DAP_Arg_deC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01181">
        <property type="entry name" value="DAPDCRBXLASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01179">
        <property type="entry name" value="ODADCRBXLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50621">
        <property type="entry name" value="SSF50621"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51419">
        <property type="entry name" value="SSF51419"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="2" id="KW-0457">Lysine biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Orn_Arg_deC_N" evidence="5">
        <location>
            <begin position="49"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="domain" description="Orn_DAP_Arg_deC" evidence="4">
        <location>
            <begin position="281"/>
            <end position="383"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02784"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PJN08550.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="433" mass="47393" checksum="6ADAEE84E7B9A6BE" modified="2018-04-25" version="1">MRPDMSEVAVEQLKFLAPDDVRTVAEEFGTPVFVYDEATVRASSKTMSTLPNAFGLTVRYSLKACPGQAIIRLFDREGFSFDASSVWEARRAVLAGVEPGRISMTAQEAVFDENLRDLIDQGLQFDAGSLHQLEEYGRAYPGGAVAIRINPGFGSGLVGRLNSGGPQSSFGIWHEQLPEVKQIVEQYGLRLVRLQSHIGSGHHWDILVDAVRTMLSFARDFQDVHTLDLGGGYRVSALQSDPVYDHTEWARVVADELKQFAEETGRRLHTEVEPGTYLTALAGSLVTKVIDKADTGAEGNSFLKINSGLTEIARPSYYGVQHPIVSVPATGGAERAADDREKFNVVGHCCIAGDVLTAKQEELAPVPLGHTEIGDYVVIERAGSYCSSMSMKNFNSYPEAAEVLRRADGSFDLIRSRQSIEQVIVNERIPEGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JNW8</accession>
    <name>A0A2M9JNW8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CG723_27725</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000013">
        <property type="protein sequence ID" value="PJN08566.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08566">
        <property type="protein sequence ID" value="PJN08566"/>
        <property type="gene ID" value="CG723_27725"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PJN08566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="112" mass="12152" checksum="66ADE0D05A8368CD" modified="2018-04-25" version="1">MGIDLELHSARPARNWRKSRATLLRNSYGHGDALADALSSLQLLGVAGRLTAVDPYGDTLMNEQESAAALNEIHELRQRCSDERQLAALDDLATLLGQCAGAPGSYLWFQGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JP79</accession>
    <name>A0A2M9JP79_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_26620</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000012">
        <property type="protein sequence ID" value="PJN08674.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08674">
        <property type="protein sequence ID" value="PJN08674"/>
        <property type="gene ID" value="CG723_26620"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041581">
        <property type="entry name" value="Glyoxalase_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18029">
        <property type="entry name" value="Glyoxalase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VOC" evidence="1">
        <location>
            <begin position="7"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN08674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="228" mass="24046" checksum="72A2A5088B5A1E65" modified="2018-04-25" version="1">MEFAEGAPCWADAALPDVESGKRFYGDLFGWTFDEGAGVEYGYYTQAYSDGRSVAALAPDRDGRTPTGWTVYFKARDAETLASAVRDAGGRLLVEPLSIGPFGTMALAADPGGTVFGLWQPGTHIGFEVQGEPGTFRRAELHARDRATVAPFYASVLGHGPTGLGLSIATGDAPARFLVHFAVTDCEATADAATRLGGRVKEEPFDTAYGRVAVLTDNQGAAFALQQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JP86</accession>
    <name>A0A2M9JP86_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DNA-directed DNA polymerase</fullName>
            <ecNumber evidence="1">2.7.7.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CG723_28015</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CB01635</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1)</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.7" evidence="1"/>
    <dbReference type="EMBL" id="NNBL01000013">
        <property type="protein sequence ID" value="PJN08607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08607">
        <property type="protein sequence ID" value="PJN08607"/>
        <property type="gene ID" value="CG723_28015"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008408">
        <property type="term" value="F:3'-5' exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1600">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011708">
        <property type="entry name" value="DNA_pol3_alpha_NTPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041931">
        <property type="entry name" value="DNA_pol3_alpha_thumb_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040982">
        <property type="entry name" value="DNA_pol3_finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029460">
        <property type="entry name" value="DNAPol_HHH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004013">
        <property type="entry name" value="PHP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003141">
        <property type="entry name" value="Pol/His_phosphatase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016195">
        <property type="entry name" value="Pol/histidinol_Pase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004805">
        <property type="entry name" value="PolC_alpha"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32294">
        <property type="entry name" value="PTHR32294"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07733">
        <property type="entry name" value="DNA_pol3_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17657">
        <property type="entry name" value="DNA_pol3_finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14579">
        <property type="entry name" value="HHH_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02811">
        <property type="entry name" value="PHP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00481">
        <property type="entry name" value="POLIIIAc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89550">
        <property type="entry name" value="SSF89550"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00594">
        <property type="entry name" value="polc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0235">DNA replication</keyword>
    <keyword evidence="5" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="3" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="POLIIIAc" evidence="8">
        <location>
            <begin position="6"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="79"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PJN08607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="1201" mass="132137" checksum="2703FA4C07FAEA57" modified="2018-04-25" version="1">MADSFVHLHNHTEYSMLDGAQKLKPMFGEVERQGMPAVAMSDHGNMFGAYEFHQVSKGFDGVKPIIGIEAYVAPSSRRNRKQEFWGPGGQRAMSDDGEGSKDVSGGGRFTHMTMWAQNVRGLRNLFYLSTEASYTGQFPAGKPRMDMELISEHADGIIATTGCPSGAVQTRLRLKQYDEARQVAASYQDIFGRENYFLELMDHGLSIERNVRDGLLRLAKDLNIPLLATNDAHYVHADQADAHDNLLCIGVGKNKADEKRFRFSGNDYYLKTADEMRGLFSEMPEACDNTLLIAERVESYGEVFDNIDEMPQFPDVPDGETQESWLRKEVMKGLVMRYGDPVPAEVLERFETEMSIIGPMGFSSYFLVVADICKYARDNNVPVGPGRGSATGSIVAYATRITELCPLEHGLLFERFLNPERINPPDVDLDFDDRQRDFMVRYVVDKYGDEYTAMVNTFGKIKAKNAIKDSSRILGYPFQHGERITKALPDDIMGKSIPLDGIFDSTHPRYGECGEIRALYENEPDVKKVIDTAKGVEGLTRGTGVHAAAVILSKTKLTDRIPLHMRAKDGVKITGFDYPSCENMGLVKMDFLGLRNLGVIDHAIQNIRENRGIHLATVDPGNGDVTDQVVIPLDDKTTYELLASGDTFGVFQLDGGGMRTLLKAMEPTRFEDIAAALALYRPGPMAANAHMNYAHRKTGRQEIQPIHPELEKALEPILGNTFHLLIYQEQIMAIARQLAGYTLGGADLLRRAMGKKKPEVLAAEWEKFHAGMQGNGYSEESIKDLWDVMLPFSGYAFNKSHTAGYGLVSYWTAYLKANYPAEYMAALLTSVGDDKDKAGIYLADARKMGVTVLQPDVNESVAEFAAIGDDVRFGLRSVRNVGDNVIESIVAGRKAGGKFGNFADFLDKVDLPALNKRAIESLIKAGAFDSLGHTRKGLTAAHEYAIDAVVPVKKAAAYGQDDLFAGLGADEGDDGTPAFGVDIKIDEAEWPRKQLLSTEREMLGMYVSAHPLDGTESILAGHRDTTIPDLIASGRTEGVVRLAGLITSVQPKMTKQGNLWAIVNLADRDGQLEVLFFPATYQLVMGALVPDSVVSVLGRLNDRDGTINLAGQELQVLDVTSAERSGAAPIQLHLPYHRVNDPSVRELKRILLAHPGPNPVRLAIQGPRKTTVYVLQETVNAGTIASDIKGSFGQDTWQGIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JP95</accession>
    <name>A0A2M9JP95_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_26685</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000012">
        <property type="protein sequence ID" value="PJN08686.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08686">
        <property type="protein sequence ID" value="PJN08686"/>
        <property type="gene ID" value="CG723_26685"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="24"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN08686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="79" mass="8767" checksum="C524D3B2383C1FBB" modified="2018-04-25" version="1">MLLALLGRVLAWLLPGGGTRRRAVSAARPVPVAPPPPRARPRSPYAREAAADYRVDVSDEPLTRPYYRYYRPTESMCAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JPB3</accession>
    <name>A0A2M9JPB3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="11">D-alanyl-D-alanine carboxypeptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CG723_26810</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CB01635</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the peptidase S11 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000012">
        <property type="protein sequence ID" value="PJN08708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08708">
        <property type="protein sequence ID" value="PJN08708"/>
        <property type="gene ID" value="CG723_26810"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009002">
        <property type="term" value="F:serine-type D-Ala-D-Ala carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018044">
        <property type="entry name" value="Peptidase_S11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001967">
        <property type="entry name" value="Peptidase_S11_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00768">
        <property type="entry name" value="Peptidase_S11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00725">
        <property type="entry name" value="DADACBPTASE1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="3" id="KW-0133">Cell shape</keyword>
    <keyword evidence="5" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword evidence="11" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Peptidase_S11" evidence="10">
        <location>
            <begin position="471"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="16"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="158"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="241"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-ester intermediate" evidence="6">
        <location>
            <position position="478"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="6">
        <location>
            <position position="481"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="545"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="645"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR618044-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR618044-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PJN08708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="802" mass="81743" checksum="5DB636AA98068F0C" modified="2018-04-25" version="1">MAGTPDRSKQQESSGGPTPEERDPRLAMARQSPERVDQATAVFSVRDVPAAGTESGSAEDSAPDPDSDSDSGSTDASGAEGSGALDSGADPEPEAGSGDGTEPGSGDEPGDARLRAAVAAWVAGPRDGSADEPEAAGAGGPDAAEGDRDADAPEADRADEPEAADDAAESEGADSGDDEADAAEDSADAEATDAPEESDVDADAESADAPEATVDDAEPADAPEAPEAEASDSDAEPSEGAEPADEAKADAGPSEEAEVPADAKPADKAEPADDAKPIDAQTKPPAVDQATAVFKAVKPPVDQPTQMLKSLGSKPAGAGKAESDAERTSKFVPLKGFDSGAPAKPKAQPKAQPTAPPAKPYVGPERTTQQPLPPLPPLDLLAELTNTPPPAETRVRTAVRRVKIWTPIVLLLAVLFAVVQTVRALPAPTLALTAKSTFTFDGDKVSLPWPAEGQGSMDVSGIGSMDQFGEQKPVPIGSVAKAMTAYVVLKDHPLQPGKDGPSIDVDAKAETEGGYDSEGESTLNTVKEGDKLSQKDALSAIMIPSANNIARLLARWDAGSEEAFVKKMNAAAKDLGMTGTTYTDPSGLKETTVSTARDQVKLGNELVKIQALMDITKLPTWKDPSGKTWQNYNRLVPYNNAVGVKTGSTTKAGGNLLFAATKDAGGETVTVVGAILGQHRAPIIDTVNAVSKTAMLAAQDAVKASTILKKGDVVGYVDDGLGGQTPVVVTKNVSAVGWAGLTVKLELADGAKGTVIPHSAKAGTQVGELKVGDGSGGAVTVPVALQKDLTEPGFGEKLTRVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JPR6</accession>
    <name>A0A2M9JPR6_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Anti-sigma factor antagonist</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CG723_25580</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CB01635</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the anti-sigma-factor antagonist family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000011">
        <property type="protein sequence ID" value="PJN08869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08869">
        <property type="protein sequence ID" value="PJN08869"/>
        <property type="gene ID" value="CG723_25580"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043856">
        <property type="term" value="F:anti-sigma factor antagonist activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.750.24">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003658">
        <property type="entry name" value="Anti-sigma_ant"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002645">
        <property type="entry name" value="STAS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036513">
        <property type="entry name" value="STAS_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13466">
        <property type="entry name" value="STAS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52091">
        <property type="entry name" value="SSF52091"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00377">
        <property type="entry name" value="ant_ant_sig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50801">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="STAS" evidence="3">
        <location>
            <begin position="10"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PJN08869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="107" mass="11469" checksum="BF686D8D23CBBCEF" modified="2018-04-25" version="1">MYIRGDHAGLVVGGRLDVRSAADARTVLHTALDDGVGDLLLDLSELDSWDATGLGVIMGAHRRAGRCGRRLVLRGVPPQMQRLLVATRLHRILAIEGGIGVESLPRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JPY1</accession>
    <name>A0A2M9JPY1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Aminobenzoate oxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CG723_25895</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000011">
        <property type="protein sequence ID" value="PJN08920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08920">
        <property type="protein sequence ID" value="PJN08920"/>
        <property type="gene ID" value="CG723_25895"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.620.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025859">
        <property type="entry name" value="AurF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009078">
        <property type="entry name" value="Ferritin-like_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012348">
        <property type="entry name" value="RNR-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11583">
        <property type="entry name" value="AurF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47240">
        <property type="entry name" value="SSF47240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PJN08920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="369" mass="42401" checksum="A6B53CD480336649" modified="2018-04-25" version="1">MSTHELYTRAPEELNWQVPAAGSARFSWEYDEGRDRLLALYQKGKDKQWDGAKRIDWGLEVDPHNPLGTPDEALTLYGTRHWAKMTDQDKGELRKHYASWQFSQFLHGEQGAMVCAARIVESVPDMDAKFYSATQTMDEARHAEIFGRFLHEKVGMLYPINDNLQSLLGDTLRDSRWDMPYLGMQVLIEGLALAAFGMIRDTTDKPLPQQILAYVMQDEARHVAFGRMALRDYYKQLTDAELREREEFVIEGCYLMRDRLRGVEVLENFGISKAEADEYSEQSEFLALFRQLLFSRIVPCVKDIGLWGKRLQQAYVDMGVFEMGNSNLDQLMAQDEEIAEKLDAERFAAEELERVAEVESTIGEGAQQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JQ44</accession>
    <name>A0A2M9JQ44_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">TetR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CG723_26335</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000011">
        <property type="protein sequence ID" value="PJN09002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN09002">
        <property type="protein sequence ID" value="PJN09002"/>
        <property type="gene ID" value="CG723_26335"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="3">
        <location>
            <begin position="2"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="25"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="111"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PJN09002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="200" mass="20860" checksum="556146D101AF074A" modified="2018-04-25" version="1">MPTARESLLDAAGTALAGRPWPLVRMIDVAAVAGVSRQTLYNEFGSKDGLARALVRREADAYLAGVDRALKEAGIEAVAEWTVTAAGSSALVRAVLTGCWGERLPAPALAGVPSSSTVPAQRRADGPLPGPGDVVKLVRERAAAALRSAGRPWAEADQLARDCELAVRLALSCLLAPPGDGGVGRLLREALSYRRRDATT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JQP6</accession>
    <name>A0A2M9JQP6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Iron ABC transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CG723_25125</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CB01635</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000010">
        <property type="protein sequence ID" value="PJN09194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN09194">
        <property type="protein sequence ID" value="PJN09194"/>
        <property type="gene ID" value="CG723_25125"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037294">
        <property type="entry name" value="ABC_BtuC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000522">
        <property type="entry name" value="ABC_transptr_permease_BtuC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30472">
        <property type="entry name" value="PTHR30472"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01032">
        <property type="entry name" value="FecCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81345">
        <property type="entry name" value="SSF81345"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="30"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="84"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="114"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="139"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="168"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="214"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="255"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="295"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="328"/>
            <end position="345"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PJN09194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="353" mass="36497" checksum="86DDBD06BE0BB712" modified="2018-04-25" version="1">MSTTTAPRVRPAGYSVVRAGGAAFLLHRRAAVAAASLVVLLAAACLAYLCVGESFIAPGEVLRVITGRPSPDELVVGTLRAPRMVVGLLVGAAFGAAGALIQTVARNPLASPDIIGISQGASALTVGAMTFGVTSYAVLPYLSVLGGLLAALLVYAFAWRGGLHATRFVLIGIGFAIALRSVTTLFMTKGDYLVAQQAQIWMTGSLNGRGWAEAAPLGWTLLVLVPFVAWAARVQRTVAMDDDTATALGVRLGRVRLGLVLLGVVLASVATGAAGPVDFVALLAPQIARRVTRTAQIPLLCSALLGAFIVVVADLLARRLFSPTELPVGVLTAAVGAPYLIWLIIRSRTGGNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JQX4</accession>
    <name>A0A2M9JQX4_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PAS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_23225</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000009">
        <property type="protein sequence ID" value="PJN09268.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN09268">
        <property type="protein sequence ID" value="PJN09268"/>
        <property type="gene ID" value="CG723_23225"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013656">
        <property type="entry name" value="PAS_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013767">
        <property type="entry name" value="PAS_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01590">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13581">
        <property type="entry name" value="HATPase_c_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00989">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08448">
        <property type="entry name" value="PAS_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07228">
        <property type="entry name" value="SpoIIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00065">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00331">
        <property type="entry name" value="PP2C_SIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PAS" evidence="1">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN09268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="775" mass="82488" checksum="C0CA3D71ACB268F1" modified="2018-04-25" version="1">MPSGDVLVLIDESGRVIEWRRPAEELFGWSAEEAVGESVTALMREVAAEGERRGESFSDAAAVLVKPVLRGTSVLWQMLAAGDTMSGQDVAALKAAFTHSPVGLHVLDNQLRVVRMSTATGGPHDTPVRHLLGKHFTEACELEDPEEEAAVAQKVLESGEPVVNRLVRRIKAPGQPTHRIHSVSYFRLEDSVGNVVGLVASTVDVTERESAQNRLAVLDTVRTQVGHRLNVMDVCRELVEAVVPAFAGIADVSVIEDVVCGEDPPPVPVHRDVPLRRAAFQGRIAGHPLGVVRPLPAGTPFSDVLSDLRPRLVAIEEDSSWLAVDPARADVIRRSGAHSLIVAPLALRGHVLGVVSFYRHQQEDPFEEEDVAVASAVCAHAALCIDNARQFMREWIIARTVQRRLLPHQPATHATVEISQLHLPAPEGGGAWSDAIALPGARTALIVGDVAGQGIAAAITMGLLRTAVHTLAALDLQPDELLARLSDTVARLVAARATLPPTDPLNREPLTAGCIIAIYDPVDLTCTIARAGLPEPVAVFPDGTSAGLAVPSGPQLAETGNAPFPATTVDLPEGSTLAMGTAALADAVLAPSGPLRRLLDGASTRPLSDLRDDVAQALTGGHPTGEAQMLLARTKALPQDRVLTRTLPADPEAAPIARAAARRQLEAWGMDEETAFTTELIVSELVGNAVRYGAPPLQVRLIFERMLTCEVSDTATSAPQVKHARTIDETGRGLFIIASVAEQWGTRYQTQGKTVWAEQPTGMSAERRNGAGRAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JR66</accession>
    <name>A0A2M9JR66_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Putative phenylalanine aminotransferase</fullName>
            <ecNumber evidence="3">2.6.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">hisC</name>
        <name evidence="3" type="synonym">pat</name>
        <name evidence="6" type="ORF">CG723_23860</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CB01635</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">May catalyze the transamination reaction in phenylalanine biosynthesis.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 3">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.-" evidence="3"/>
    <dbReference type="EMBL" id="NNBL01000009">
        <property type="protein sequence ID" value="PJN09365.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN09365">
        <property type="protein sequence ID" value="PJN09365"/>
        <property type="gene ID" value="CG723_23860"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004400">
        <property type="term" value="F:histidinol-phosphate transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01023">
        <property type="entry name" value="HisC_aminotrans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01513">
        <property type="entry name" value="Phe_aminotrans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001917">
        <property type="entry name" value="Aminotrans_II_pyridoxalP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005861">
        <property type="entry name" value="HisP_aminotrans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024892">
        <property type="entry name" value="Pat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01141">
        <property type="entry name" value="hisC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00599">
        <property type="entry name" value="AA_TRANSFER_CLASS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="3" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotran_1_2" evidence="5">
        <location>
            <begin position="46"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="3">
        <location>
            <position position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PJN09365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="377" mass="40800" checksum="455351B4A08E34E6" modified="2018-04-25" version="1">MSNISPDEAVPRSGKGSSPRLRALLDTIPAYVPGKSAASADRPSWKLSSNENPYPPLPGVLDAVTVAAGQMHRYPDLHATELTNRLAEHLSIPAARIALGTGSSGLLQQLMQISTAPGDEVVYAWRSFESYPIVTRLFGACPVEVPLAHDEAHDLDAMARAVTDRTRLVFVCAPNNPTGNALRRDLLEPFLDRLPADVVVVLDEAYVEFNDDPLCADGVELSRDRPNVVALRTFSKAYGLAGLRVGYAVAHEPVAEALRKVAVPFGVSTTAQSAAIASLDRQAELMERVEELVGERIRVREALLEQGWTVPDSQANFVWFRLGQQTSAFAEHCQNAGVTVRPYGQDGVRITIGERQANDAALTAAGHFRAQLLHSLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-06-02" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JRH2</accession>
    <name>A0A2M9JRH2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">CsbD family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CG723_22195</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CB01635</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0337 (CsbD) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000008">
        <property type="protein sequence ID" value="PJN09481.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN09481">
        <property type="protein sequence ID" value="PJN09481"/>
        <property type="gene ID" value="CG723_22195"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008462">
        <property type="entry name" value="CsbD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036629">
        <property type="entry name" value="YjbJ_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05532">
        <property type="entry name" value="CsbD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69047">
        <property type="entry name" value="SSF69047"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CsbD" evidence="3">
        <location>
            <begin position="5"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="30"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="31"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PJN09481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="57" mass="6192" checksum="F4E0ECE293B2442D" modified="2018-04-25" version="1">MTANEKAKAKTEQVTGAAKEIAGRAVGNERLTVEGRTERKKGDAREAKEKIKDVGKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JRQ5</accession>
    <name>A0A2M9JRQ5_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Carbonic anhydrase</fullName>
            <ecNumber evidence="3">4.2.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CG723_22160</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CB01635</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the reversible hydration of carbon dioxide to form bicarbonate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>H(+) + hydrogencarbonate = CO2 + H2O</text>
            <dbReference type="Rhea" id="RHEA:10748"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="EC" id="4.2.1.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the beta-class carbonic anhydrase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.1" evidence="3"/>
    <dbReference type="EMBL" id="NNBL01000008">
        <property type="protein sequence ID" value="PJN09477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN09477">
        <property type="protein sequence ID" value="PJN09477"/>
        <property type="gene ID" value="CG723_22160"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004089">
        <property type="term" value="F:carbonate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015976">
        <property type="term" value="P:carbon utilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001765">
        <property type="entry name" value="Carbonic_anhydrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015892">
        <property type="entry name" value="Carbonic_anhydrase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036874">
        <property type="entry name" value="Carbonic_anhydrase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11002">
        <property type="entry name" value="PTHR11002"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00484">
        <property type="entry name" value="Pro_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00947">
        <property type="entry name" value="Pro_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53056">
        <property type="entry name" value="SSF53056"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00704">
        <property type="entry name" value="PROK_CO2_ANHYDRASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0456">Lyase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PJN09477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="218" mass="22395" checksum="376EC7922E547253" modified="2018-04-25" version="1">MTADAHVIPDEAFKLLMAGNHRFVAGSPEHPNQDAARRAALASVQQPFAVLFGCSDSRLAAEIIFDRGLGDLFVVRTAGHVAGPEVLGSLEYGVGLLNCPLVVVLGHEGCGAVAATRTAIENGVAADGYVRDVIERVTPSVLAARAAGLTQDSAIIAAHTRNTVDLLLDRSRILADHVTAGRTAVVGLTYSLADGSAQLVAAHGLTAATAHPANAHTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JS37</accession>
    <name>A0A2M9JS37_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_20915</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000007">
        <property type="protein sequence ID" value="PJN09674.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN09674">
        <property type="protein sequence ID" value="PJN09674"/>
        <property type="gene ID" value="CG723_20915"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014676897" evidence="1">
        <location>
            <begin position="34"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN09674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="169" mass="17755" checksum="A5646CE2224B2E26" modified="2018-04-25" version="1">MRIRSVVSALALVLGALFAPGFGVFSSATDAQAATKISHATATSMFSQVGITWSSSGGCSNRNNSTCTSFDQLNLATAQGAQTLKRATGCALNITGGTETGHASGTYSHWNGYKLDYGKNTCVTNYIKNTFTYIGLRGDGAPQYQSGSGNIYADEGNHWDVLYYNCGGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JS77</accession>
    <name>A0A2M9JS77_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_21160</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000007">
        <property type="protein sequence ID" value="PJN09714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN09714">
        <property type="protein sequence ID" value="PJN09714"/>
        <property type="gene ID" value="CG723_21160"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="13"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN09714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="67" mass="7259" checksum="19525D89AA4E849F" modified="2018-04-25" version="1">MAKALLGYVGGSDPRLLAEMRRLQQRVQDLESELVRIQSENDALAAAASHDSLLESIDVPQAEPALT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-09-29" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JS91</accession>
    <name>A0A2M9JS91_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CG723_21205</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000007">
        <property type="protein sequence ID" value="PJN09723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN09723">
        <property type="protein sequence ID" value="PJN09723"/>
        <property type="gene ID" value="CG723_21205"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030234">
        <property type="term" value="F:enzyme regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006808">
        <property type="term" value="P:regulation of nitrogen utilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002187">
        <property type="entry name" value="N-reg_PII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011322">
        <property type="entry name" value="N-reg_PII-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015867">
        <property type="entry name" value="N-reg_PII/ATP_PRibTrfase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002332">
        <property type="entry name" value="N-reg_PII_urydylation_site"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30115">
        <property type="entry name" value="PTHR30115"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00543">
        <property type="entry name" value="P-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039144">
        <property type="entry name" value="GlnB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00340">
        <property type="entry name" value="PIIGLNB"/>
    </dbReference>
    <dbReference type="SMART" id="SM00938">
        <property type="entry name" value="P-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54913">
        <property type="entry name" value="SSF54913"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51343">
        <property type="entry name" value="PII_GLNB_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00496">
        <property type="entry name" value="PII_GLNB_UMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="modified residue" description="O-UMP-tyrosine" evidence="2">
        <location>
            <position position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR039144-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR602187-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PJN09723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="112" mass="12251" checksum="496E6A6D7587C8DE" modified="2018-04-25" version="1">MKLITAVVKPHRLDEIKEALQAFGIQGLTVTEASGYGRQRGHTEVYRGAEYTVDLVPKIRIEVLVEDDDAEQLIDVVVKAARTGKIGDGKVWAVPVETAVRVRTGERGPDAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-09-29" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JS98</accession>
    <name>A0A2M9JS98_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Alpha-ketoglutarate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CG723_20875</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CB01635</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000007">
        <property type="protein sequence ID" value="PJN09667.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN09667">
        <property type="protein sequence ID" value="PJN09667"/>
        <property type="gene ID" value="CG723_20875"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="50"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="80"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="180"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="234"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="271"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="300"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="325"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="357"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="394"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="8"/>
            <end position="416"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PJN09667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="438" mass="47066" checksum="735AE0D80F7F6266" modified="2018-04-25" version="1">MGREQWKKILVGSAGNMVEWFDWFVYASFATYFAGAFFPDGNPTAQLMNTAGIFAVGFFMRPVGGWLLGRVGDRKGRKAALTLTVTLMSASAVLIAIAPTYAVAGYGGAVVLLIARLLQGLSVGGEYAASATYLTEASDPSRRGFASSFQYVSMTAGQIVGLGLQIILQRTLSDDALHSWGWRIPFIIGALGAAIIFYLRRNMLETDVYEESADDAGADSKGTLTALWAHRREAFLVMALTMGGTVAYYTYTTYLTKYLSNSAGLSKQTATLVSFCALIVFACIQPLAGKLSDRIGRRPLLITFAVGSTFLTVPIMTMLKHAGSFWPALGLALLALVVVTGYTSINACVKAELFPTGIRALGVALPYAIANALFGGTAEYVALWFKDAGLESGFYWYVAGCAAVSLIVYLTMRETRDIDLNRVEVAVPEAEKRAAEAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JSV1</accession>
    <name>A0A2M9JSV1_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Succinate--CoA ligase [ADP-forming] subunit beta</fullName>
            <ecNumber evidence="6">6.2.1.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Succinyl-CoA synthetase subunit beta</fullName>
            <shortName evidence="6">SCS-beta</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">sucC</name>
        <name evidence="9" type="ORF">CG723_19795</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CB01635</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>ATP + CoA + succinate = ADP + phosphate + succinyl-CoA</text>
            <dbReference type="Rhea" id="RHEA:17661"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57292"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.2.1.5"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="6">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="6">Carbohydrate metabolism; tricarboxylic acid cycle; succinate from succinyl-CoA (ligase route): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Heterotetramer of two alpha and two beta subunits.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the succinate/malate CoA ligase beta subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.2.1.5" evidence="6"/>
    <dbReference type="EMBL" id="NNBL01000006">
        <property type="protein sequence ID" value="PJN09971.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN09971">
        <property type="protein sequence ID" value="PJN09971"/>
        <property type="gene ID" value="CG723_19795"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00223">
        <property type="reaction ID" value="UER00999"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004775">
        <property type="term" value="F:succinate-CoA ligase (ADP-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.261">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00558">
        <property type="entry name" value="Succ_CoA_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013650">
        <property type="entry name" value="ATP-grasp_succ-CoA_synth-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005811">
        <property type="entry name" value="CoA_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017866">
        <property type="entry name" value="Succ-CoA_synthase_bsu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005809">
        <property type="entry name" value="Succ_CoA_synthase_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016102">
        <property type="entry name" value="Succinyl-CoA_synth-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11815">
        <property type="entry name" value="PTHR11815"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08442">
        <property type="entry name" value="ATP-grasp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00549">
        <property type="entry name" value="Ligase_CoA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001554">
        <property type="entry name" value="SucCS_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52210">
        <property type="entry name" value="SSF52210"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01016">
        <property type="entry name" value="sucCoAbeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01217">
        <property type="entry name" value="SUCCINYL_COA_LIG_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 6 9" id="KW-0436">Ligase</keyword>
    <keyword evidence="5 6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 6 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 6" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="ATP-grasp" evidence="8">
        <location>
            <begin position="9"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding; shared with subunit alpha" evidence="6">
        <location>
            <begin position="319"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="45"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="52"/>
            <end position="54"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="92"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="95"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="100"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="192"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="206"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="257"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared with subunit alpha</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00558"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PJN09971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="393" mass="41229" checksum="5BE448B6C46331C6" modified="2018-04-25" version="1">MDLFEYQARDLFAKHGVPVLAGEVIDTPEAAREATERLGGKSVVKAQVKVGGRGKAGGVKLAATPDEAVARATDILGMDIKGHTVHKVMIAETAPEILEEYYVSYLLDRTNRTFLAMASVQGGVEIEVVAEENPDALAKVPVDANEGVSKEKAQEIVAQAKFPAEVADQVADILVTLWDTFIKEDALLVEVNPLAKVASGKVIALDGKVSLDENADFRQPEHEALEDKDAANPLEAAAKAKNLNYVKLDGEVGIIGNGAGLVMSTLDVVAYAGENHGNVKPANFLDIGGGASAQVMANGLEIILGDPDVKSVFVNVFGGITACDEVANGIVQALALLADKGEEVTKPLVVRLDGNNAELGRQILSDANHPLVQRVDTMDGAADKAAELAAAAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JSV5</accession>
    <name>A0A2M9JSV5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CG723_19490</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CB01635</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the N-acetylmuramoyl-L-alanine amidase 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000006">
        <property type="protein sequence ID" value="PJN09922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN09922">
        <property type="protein sequence ID" value="PJN09922"/>
        <property type="gene ID" value="CG723_19490"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008745">
        <property type="term" value="F:N-acetylmuramoyl-L-alanine amidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009253">
        <property type="term" value="P:peptidoglycan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06583">
        <property type="entry name" value="PGRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.130">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.80.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036505">
        <property type="entry name" value="Amidase/PGRP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002502">
        <property type="entry name" value="Amidase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013517">
        <property type="entry name" value="FG-GAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013519">
        <property type="entry name" value="Int_alpha_beta-p"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028994">
        <property type="entry name" value="Integrin_alpha_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015510">
        <property type="entry name" value="PGRP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006619">
        <property type="entry name" value="PGRP_domain_met/bac"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11022">
        <property type="entry name" value="PTHR11022"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01510">
        <property type="entry name" value="Amidase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01839">
        <property type="entry name" value="FG-GAP"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00644">
        <property type="entry name" value="Ami_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00191">
        <property type="entry name" value="Int_alpha"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00701">
        <property type="entry name" value="PGRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55846">
        <property type="entry name" value="SSF55846"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69318">
        <property type="entry name" value="SSF69318"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51470">
        <property type="entry name" value="FG_GAP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014870531" evidence="6">
        <location>
            <begin position="44"/>
            <end position="911"/>
        </location>
    </feature>
    <feature type="domain" description="PGRP" evidence="8">
        <location>
            <begin position="270"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="domain" description="N-acetylmuramoyl-L-alanine amidase" evidence="7">
        <location>
            <begin position="286"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="44"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="124"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="189"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="64"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="198"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="224"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="253"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00644"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PJN09922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="911" mass="92088" checksum="9BB545291EC084A0" modified="2018-04-25" version="1">MSPRNPRARRSHAYKPLSLKRRAWVTVGAVVLGGAGVVTYAVASPEASGGSGPSATTPRPVKVRSAELKADGSTKRELPRTGTEPFSLVGVTWDKQSAELKGTAQVRTRSSVTGKWTDWVSVNTDSHLPDPDTAESKNGVRGMSESRWVGPSDGVEARVVAADGSSTALPKGLTLAMVDPGVTSKEAKAAKTSAAAGGPQNAAYTTDLAESPSPSPSDSAPESPSPSASPSDSAPAGSPSPSDSASASASPSPSPTPTKPPAPPSTVKQPPIIMRSEWKPDTSLAVNYSPPEYIDKVQAAFIHHTVDANDYSCADSAKLIRADYAYHVKPEPDGNGWKDIGYNFLVDKCGQIFEGREGGIDEPVLGAHTYGFNSYSTGIAILGNFVDSKPSRAAMESAARVAAYKLGQYGVDPNGSVNLVAAADTGVYKTGETATLRTVSGHQDAYATECPGKQLEDRLGTIRSFAAGAGRSSAIPTADVNRDGISDLVTGLPSASSGGRVVVVPGGASGPDSAKKISLTQSSPGVPGAGETGDQWGAAVATGDINGDGRADLAIGQPGENDTSSHADRGAVTILYGPAFTTGAQMNLDEGFYANGAKYGSAVAVGDFNADGKADVFASSTGTGGTWTARYAEGQESSSNITSGDTALSYEDATSGDFNKDGYADVALNYRDSTSIGRVVWFKGGRNGLTKAGTLTVKGGRSIAAGDINGNGVDDIVIGQPYTAESGAYAGGQVTAVYGTAGTGLTATGAKVIHQATTGVPGSAESGDALGASVSVGDYNADGYADVLAGAPNEDITRTSNRSNAGTSLLFKGSSTGLTGTGAIAVSQDEPGVAGSTETNDNLGSAVSLTDLTGFGRADLVIGAAGEDAGNGTLLYVPSNSTGLGLSTSKYYGLTQLGTATGNHLGTTLAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JTS1</accession>
    <name>A0A2M9JTS1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Pyridine nucleotide-disulfide oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CG723_18010</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CB01635</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ferredoxin--NADP reductase type 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000005">
        <property type="protein sequence ID" value="PJN10285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN10285">
        <property type="protein sequence ID" value="PJN10285"/>
        <property type="gene ID" value="CG723_18010"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021163">
        <property type="entry name" value="Ferredox_Rdtase_adrenod"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000362">
        <property type="entry name" value="FNR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5 8" id="KW-0521">NADP</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyr_redox_2" evidence="9">
        <location>
            <begin position="6"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="15"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="40"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="48"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="198"/>
            <end position="199"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="210"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="361"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="368"/>
            <end position="370"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="368"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000362-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000362-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PJN10285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="454" mass="49598" checksum="D32156ED16FF753F" modified="2018-04-25" version="1">MPRPLRVAVVGAGPAGIYAADALLKSAVAEDPGVSIDLFERMPAPFGLIRYGVAPDHPRIKGIITALHQVLDKPQIRLFGNVDYPGDISLDDLRSFYDAVIFSTGATADRALDIPGIDLDGSYGAADFVSWYDGHPDVPRTWPLEAEKVAVLGVGNVALDVARILAKTADELLPTEIPPNVYDGLKANKALEVHVFGRRGPAQAKFSPMELRELDHSPNIEVIVDPEDIDYDDGSIATRRGNKQADMVAKTLENWAIRDVGTRPHKLFLHFFESPTEILGENGEVTGLRTERTALDGTGNVKGTGEFKDWDVRSVYRAVGYLSDELPKLPWDLASGTVPDKGGRVIEESGEHLQSTYVTGWIRRGPVGLIGHTKGDANETVASLLDDRENGRLSTPSSPDPEAVDAFLDERNVRYTTWDGWYRLDAAEKALGEPEGRERVKIVEREDMLKASGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JTW1</accession>
    <name>A0A2M9JTW1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Alpha/beta hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CG723_18130</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000005">
        <property type="protein sequence ID" value="PJN10303.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN10303">
        <property type="protein sequence ID" value="PJN10303"/>
        <property type="gene ID" value="CG723_18130"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013595">
        <property type="entry name" value="Pept_S33_TAP-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08386">
        <property type="entry name" value="Abhydrolase_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Abhydrolase_4" evidence="3">
        <location>
            <begin position="152"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PJN10303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="236" mass="24546" checksum="96AE7D5B4AA42729" modified="2018-04-25" version="1">MSATIRTVTYPTGREQKPLDIHNSPQAGGPCVLLWHGIGSDERDVMIPLAQGMAERGLTVLVPDWRADTPDEGRAHLTDSLRFAHDFAGPSRQLVVAGWSAGAGAALGVALDPDHFGGPSSRPPAAVVGIAGGYRRPARTTGAVPLQALGRATARVPVRLVHGTEDPAVPVESSREMHEALRAHGWDCALSEQATDHAGVLGCVYNPVAGRCVGDASVSAFCEATAEVVAAVARSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JTX3</accession>
    <name>A0A2M9JTX3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Monoamine oxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CG723_17965</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CB01635</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000005">
        <property type="protein sequence ID" value="PJN10278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN10278">
        <property type="protein sequence ID" value="PJN10278"/>
        <property type="gene ID" value="CG723_17965"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002937">
        <property type="entry name" value="Amino_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001613">
        <property type="entry name" value="Flavin_amine_oxidase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01593">
        <property type="entry name" value="Amino_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00757">
        <property type="entry name" value="AMINEOXDASEF"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amino_oxidase" evidence="3">
        <location>
            <begin position="22"/>
            <end position="454"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PJN10278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="464" mass="50211" checksum="092F6F5C87AAFD07" modified="2018-04-25" version="1">MWEQTEMDLVESEVVVVGGGYAGLAAALQLHDEGVDFTLVEAADRVGGRVLTETRPAGVTLDHGGQWVGPTQTHLLALADRFGCATFPTWETGKHVEVWHDGGTVPYIGAAPADGPGIAEYTRVSEVLDELAGTVDTRQPWRTPGFAEWDAQTAESFFRAQTDDADARRRLALAVQGLWCAEPYEISLFHVLFYMAAAGGYEQLMETRGCAQDSRFVTGAAGPARAVADLLGRRVRLGEQVQSIEYDEAGVRVRTTSTVFEARRVIVALPPQAVRTIRFAPGLPVSRDGWLSHSPMGRVAKVHAVYDSPFWRAAGLSGVATFYDDGPVGVVFDNSPHDASRGVLVGFVYGDRVTDWSDLDDTGRREAVLESFTTVVGEEAARPLDYTEKIWSRDTFAKGGYEAYVTPGGWTGYGRRGWREPTGTVHWAGTETASLWNGYIDGAISSGLRAADEVVSALSSQAEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JUG3</accession>
    <name>A0A2M9JUG3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">FAD-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_18685</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000005">
        <property type="protein sequence ID" value="PJN10509.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN10509">
        <property type="protein sequence ID" value="PJN10509"/>
        <property type="gene ID" value="CG723_18685"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003885">
        <property type="term" value="F:D-arabinono-1,4-lactone oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.45.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.43.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007173">
        <property type="entry name" value="ALO_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016167">
        <property type="entry name" value="FAD-bd_PCMH_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010031">
        <property type="entry name" value="FAD_lactone_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016171">
        <property type="entry name" value="Vanillyl_alc_oxidase_C-sub2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43762">
        <property type="entry name" value="PTHR43762"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04030">
        <property type="entry name" value="ALO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000136">
        <property type="entry name" value="LGO_GLO"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="SSF56176"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="2">
        <location>
            <begin position="15"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN10509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="424" mass="45506" checksum="3D0CDDB6C5B8AA19" modified="2018-04-25" version="1">MPATDTPLRNWAGNVTFGAARVHRPTSEAELSRTVASAEKVRVLGSGHSFNRIADTDGDLVLLDGLARRVRVSEDRATVSVSAGMRYAEVASALQERSLALANLASLPHISVAGSCATGTHGSGDSLRGLATAVTGIELIGPDGTRTTLDRASDPDRFPGAVVNLGALGVVVGMTLAVEPAFDVAQWVYDDVRLDRIAEDFDTVFGAAYSVSAFTDWRAETATVWLKRRTDRLPTGTPGDRWMGGLLADGPRHPVPGMPPSSCTEQLGVPGPWHERLPHFRPEFTPSNGEELQSELLLPREAAADAMAALRALGDRIAPVLLVSEIRTVAADDLWLSPSHGRASLALHFTWVRRPDDVLPVIGAIEERLLPLGARPHWGKLTTAAPRTVAALYERAPDFRRLRQELDPAGKFSNAFVTELVAGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JUG5</accession>
    <name>A0A2M9JUG5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_15005</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000004">
        <property type="protein sequence ID" value="PJN10531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN10531">
        <property type="protein sequence ID" value="PJN10531"/>
        <property type="gene ID" value="CG723_15005"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="68"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="92"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="124"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="171"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN10531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="261" mass="26224" checksum="8B2702FA77A7132A" modified="2018-04-25" version="1">MRTVEHWRENARSGQTHDPNEVTVQLDGAGRQLDELIAARREGAGAADKEVPVFVDDSGRRNRRYRRFGAIVGMICAVYAVVIVATLLSGNSNAPWLPITGQDRDKPAGKVDTPPLPADPAAEPSSSTGATAGPSASGTGSVSSEPGAGSSTGPEGSESAKPDDKPGKSPDPKPSGGPGKPDPGHSPDPGSGPSEEPSSPGPGEPSPSDSGPPVEPTESPAQGGTETVAALPVESPVESPIDPSQIPAGPSAASFPESGIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JUJ6</accession>
    <name>A0A2M9JUJ6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CG723_15205</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000004">
        <property type="protein sequence ID" value="PJN10566.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN10566">
        <property type="protein sequence ID" value="PJN10566"/>
        <property type="gene ID" value="CG723_15205"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PJN10566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="191" mass="20255" checksum="D7BDA494BCAE617A" modified="2018-04-25" version="1">MIVALLAGFGVWKFWLSDDPLVAVPDRVCSRSLPGDSLRPLLPERGEAFEEYASDFSPRGSLSAPGKCVLSGGGKSVHIGYYVVFWPDGYRKEDVDRDAKKPGNLPVTLGKAKGYVEGRAVKLFVNCPRVNGHDGLLQVTASLGGESGKLKDRPTMGRVAALAADSARALGQRVEGCDSATRLPDGVPSIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JUU3</accession>
    <name>A0A2M9JUU3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Class F sortase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_15710</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000004">
        <property type="protein sequence ID" value="PJN10655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN10655">
        <property type="protein sequence ID" value="PJN10655"/>
        <property type="gene ID" value="CG723_15710"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05829">
        <property type="entry name" value="Sortase_F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005754">
        <property type="entry name" value="Sortase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023365">
        <property type="entry name" value="Sortase_dom-sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042001">
        <property type="entry name" value="Sortase_F"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04203">
        <property type="entry name" value="Sortase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63817">
        <property type="entry name" value="SSF63817"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN10655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="228" mass="23722" checksum="EB7848E308E38DCE" modified="2018-04-25" version="1">MADGERPHGNGRLVTGVAWAVLLLGLWVWGREVTDFHGLSAPTTGDAAAVGRPLGIELPPAHKPMSMSGAKPQSIDVSALKIEAPVTVSGLDGAGAIDPPPFSEAGVVGWYGGGAKPGERGTALLVGHVDTDTRPAVFYHLSSAKPGDKVRVGRDDGSVAEFTVDDVQVFSRARFDAKKAYGQRQSDRAELRLITCGGSFDRASHTYTANVVVSAYLTGVTNAPASVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JVC0</accession>
    <name>A0A2M9JVC0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Hyaluronidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CG723_16550</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000004">
        <property type="protein sequence ID" value="PJN10788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN10788">
        <property type="protein sequence ID" value="PJN10788"/>
        <property type="gene ID" value="CG723_16550"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016231">
        <property type="term" value="F:beta-N-acetylglucosaminidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.379.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011496">
        <property type="entry name" value="Beta-N-acetylglucosaminidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000421">
        <property type="entry name" value="FA58C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029018">
        <property type="entry name" value="Hex-like_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015882">
        <property type="entry name" value="HEX_bac_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00754">
        <property type="entry name" value="F5_F8_type_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02838">
        <property type="entry name" value="Glyco_hydro_20b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07555">
        <property type="entry name" value="NAGidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="SSF49785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55545">
        <property type="entry name" value="SSF55545"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50022">
        <property type="entry name" value="FA58C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014948608" evidence="4">
        <location>
            <begin position="31"/>
            <end position="991"/>
        </location>
    </feature>
    <feature type="domain" description="F5/8 type C" evidence="5">
        <location>
            <begin position="848"/>
            <end position="989"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="32"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="854"/>
            <end position="897"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="39"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PJN10788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="991" mass="105764" checksum="05D1D92F2A7EECB2" modified="2018-04-25" version="1">MQLRRHRKGAAAIAVAVIASALGGASGAVAAPPGPTLSTGDRDSDTGTPAVWPRPQSLRTASGAESVTVTDDVVLVTGRGADRYAVDALRTVLRGAGARHITEVDDEKAVPDGPALVVRIGSVAAGTASGDGWGAADARPGRGQGLETALGALGASARKDLPSGGYRLAAGRTDGRDTVAMEGVGDDGLFHAVQTFRQLVSGRKVAGVVVRDWPGTAVRGMTEGFYGTPWTREQRLDQLDFMGRTKQNRYLYAPGDDLYRQARWRETYPADQRADFRALAERARANHVTLSWAVAPGQAMCMSSDDDVRALNRKLDAMWALGVRAFQLQFQDVSYSEWHCEADARTFGSGPKAAARAQARVANAVARHLAARHPGAGPLSLMPTEFYQDGSTEYRGALAGGLDDSVEVAWTGIGVVPRTITGRELAGARAAFGSGHSLVTMDNYPVNDYAQDRIFLGPYTGREPAVAMGSAALLANAMEQPAASRIPLFTTADYAWNPRDYRPQESWKAALDDLAGGDAPTREALAALAGNDASSVLGEDESAYLKPVLSGFWDSRTKVLTDRARYEAAAKKLRDAFTVMRRAPERLKSTALDAEVRPWSDQLARYGEAGETAVDMLDAQARGDGAAAWRAARLLERRRAGLESRQVTVGRGVLDPFLDRAQKAYAAWAGTGRADATRDGEAKLPRARRLTAVTVLADPGTHGTVQVHVPGEGWKSVGTLTDSGFTERRPKDVRADAIRVSGASKGAVRHVVPWYADSPDASFELARTELDAEIGGGARRVTARLTPQRPGSVEGRLSAEGPHGIKVTLPAQASLPRGTQVSAPVDITVPEGTPAGTYDVPVSFAGTTRTVSVRAYPRTAGPDLAREGRPSSSADETTDFPASAASDGDPETRWSSPAEDGAWWQVELAKPVRLGQVVLHWQDAYAKGYRVQTSADGKSWRTAATVKDGHGGRESVRMDARDTRFVRIQGDERATRYGYSLWSVEAYAVAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JVC2</accession>
    <name>A0A2M9JVC2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Penicillin-binding protein 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">mrdA</name>
        <name evidence="6" type="ORF">CG723_16825</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000004">
        <property type="protein sequence ID" value="PJN10835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN10835">
        <property type="protein sequence ID" value="PJN10835"/>
        <property type="gene ID" value="CG723_16825"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008658">
        <property type="term" value="F:penicillin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009002">
        <property type="term" value="F:serine-type D-Ala-D-Ala carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005311">
        <property type="entry name" value="PBP_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036138">
        <property type="entry name" value="PBP_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001460">
        <property type="entry name" value="PCN-bd_Tpept"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017790">
        <property type="entry name" value="Penicillin-binding_protein_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03717">
        <property type="entry name" value="PBP_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00905">
        <property type="entry name" value="Transpeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56519">
        <property type="entry name" value="SSF56519"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03423">
        <property type="entry name" value="pbp2_mrdA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="17"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="domain" description="PBP_dimer" evidence="5">
        <location>
            <begin position="61"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="domain" description="Transpeptidase" evidence="4">
        <location>
            <begin position="298"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="680"/>
            <end position="726"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF03717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PJN10835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="726" mass="78387" checksum="F76FB8508171208C" modified="2018-04-25" version="1">MTNIPETGRTPRVQIRLVILQILVLSLLLTLGGRLWYLQIRNGAEYAKEASGNHVQQVVSPAVRGSILDARGVPIADNETRLVVSASRTDLMKMPDDGKAVLAKLADVLGMKSKDVTEKVRLCDAKTPQPCWNGSPYQPIPITDEATPKQALQIRERSEDFPGITAEPEAVRRYAGPGGSNTAQVLGYLSPVTDAEIEKAKDTSSPYLRSDQVGRSGLERTYDKELRGKAGVTRYEVDNLGRVIGRAKSDEAEPGANVVTSIDARVQGVAERELNEAMKTARQQFDKITGENYKADSGAVVVMEAKTGRIVSMASAPSYDPNVWIGGISAKDYKQLTGKGSDYPLLNRAIQGQSAPGSTFKVISTAAAAEAGYKWDGDYPCTSSYSVGGQVFKNFEGENFGPISLGRALEVSCDTVFYGLADREWKKDGGINPKGTPKDYFYKAAHQFGLGKTTGIDLPNEVTGRVPDRQWKKAFWKANKDSWCKTGKKDGTYVEKIAYENCLEGNKMREGDSINYSIGQGDTLLTPIQEAMIYGALANGGTEYVPTIGKAIISADGKTVREIKPKVKAKLPITKATHKGMDDALAGVVTRGTAAWKFGGWPQDKIPLHAKTGTAEVYGKQTTSWLATYSKDYSVIMTISQAGTGSGASGEAVRKIYNALYGVAADGTIDKKKALLPEPEKNLPKIQRDGSIDAPTIKPYKPAEPSPSPEQELAAVIGTPVTGRRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-06-02" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JVE3</accession>
    <name>A0A2M9JVE3_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ribosomal silencing factor RsfS</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2 4" type="primary">rsfS</name>
        <name evidence="4" type="ORF">CG723_16940</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CB01635</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Interacts with ribosomal protein L14 (rplN).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the Iojap/RsfS family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000004">
        <property type="protein sequence ID" value="PJN10856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN10856">
        <property type="protein sequence ID" value="PJN10856"/>
        <property type="gene ID" value="CG723_16940"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042256">
        <property type="term" value="P:mature ribosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090071">
        <property type="term" value="P:negative regulation of ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017148">
        <property type="term" value="P:negative regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01477">
        <property type="entry name" value="Iojap_RsfS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004394">
        <property type="entry name" value="Iojap/RsfS/C7orf30"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21043">
        <property type="entry name" value="PTHR21043"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="SSF81301"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00090">
        <property type="entry name" value="rsfS_iojap_ybeB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0678">Repressor</keyword>
    <keyword evidence="2" id="KW-0810">Translation regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="123"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="136"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PJN10856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="152" mass="16933" checksum="0844D0AA55C94DBB" modified="2018-04-25" version="1">MTATDRSIELITAAAQAAADKLAHDIIAYDVSDVLSITDAFLLASAPNDRQVKSIVDEIEERLNKELGAKPVRREGDRDARWILLDYVDIVVHVQHSEERVFYALERLWKDCPELELPADAKATRGKAAEHAQATQAAEEAEELRELGGELR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JVK7</accession>
    <name>A0A2M9JVK7_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">TerB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_17200</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000004">
        <property type="protein sequence ID" value="PJN10899.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN10899">
        <property type="protein sequence ID" value="PJN10899"/>
        <property type="gene ID" value="CG723_17200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007791">
        <property type="entry name" value="DjlA_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029024">
        <property type="entry name" value="TerB-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05099">
        <property type="entry name" value="TerB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158682">
        <property type="entry name" value="SSF158682"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TerB" evidence="1">
        <location>
            <begin position="132"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN10899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="227" mass="23588" checksum="E7D2BC3450E9728D" modified="2018-04-25" version="1">MARAGARPLSGLIGVRTAWTTVGDGEFFCPGCGGDRNYRRRTGRRRFVLLGIPLVPRGATGPVVECAACEDRFAADVLDHPTTHRFSAMLRDAVHTVVLAVLSAGGVSSRTALETAVATLRGAGFDDCTDVQLAALVEALLTDAGRVPEHCGPGAGLAIELHEALDPLAPHLAPAGRESILLQGARIALADGPYTPAERDVLSTAGAALTMCTDEVSQLLEAARTPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-09-29" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JVL0</accession>
    <name>A0A2M9JVL0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Disulfide bond formation protein DsbA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_16660</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000004">
        <property type="protein sequence ID" value="PJN10807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN10807">
        <property type="protein sequence ID" value="PJN10807"/>
        <property type="gene ID" value="CG723_16660"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001853">
        <property type="entry name" value="DSBA-like_thioredoxin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01323">
        <property type="entry name" value="DSBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DSBA" evidence="1">
        <location>
            <begin position="11"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN10807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="214" mass="23742" checksum="FC48AC2016D595B6" modified="2018-04-25" version="1">MRRTMSEKTPVDFWFDPLCPWAWMTSRWVLEVEKVRDIKVRWHLMSLAVLNEDKLDDLPDDYRELLETKAWGPVRVVIAAQEEHGAEVLGDLYTALGTRIHNGGEGPTKEAVAAALEEVGLPASLLDHWDGTKYEPELRASHKEGIDKVGQDVGTPVIAVPGADGEQIAFFGPVVTPAPKGEEAARLWDGTLLVASVPGFYEIKRTRTQGPVFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JVT5</accession>
    <name>A0A2M9JVT5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CG723_16085</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000004">
        <property type="protein sequence ID" value="PJN10938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN10938">
        <property type="protein sequence ID" value="PJN10938"/>
        <property type="gene ID" value="CG723_16085"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031423">
        <property type="entry name" value="Phosphatase_SCO2771"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15698">
        <property type="entry name" value="Phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PJN10938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="265" mass="28735" checksum="321BDB046BA0A5E4" modified="2018-04-25" version="1">MPIPGTPSRAALVDHLIRTRIAGDVATPRDNNLSHYRRLANGDRHYWLGLELGDRWTDEQDVLAVMAERCGVNDDPEYRFGQDTIDPQLTVDALERMGARLRKAAAGKERVLFATGHPGGLLDVHRATAAALRAAGCEIVVIPEGLSTDEGMVFQFADVAMLERGATLWHTHSPDPMARILDGLEREERALPNLVVADHGWAGCAGQRGIDSIGYADCNDPALFIGEAEGTLQVTVPLDDHVTSPRHYDPMTAYLLDAAGLSPTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JVT9</accession>
    <name>A0A2M9JVT9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Precorrin-6A synthase (Deacetylating)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CG723_08125</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CB01635</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the precorrin methyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN10974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN10974">
        <property type="protein sequence ID" value="PJN10974"/>
        <property type="gene ID" value="CG723_08125"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043819">
        <property type="term" value="F:precorrin-6A synthase (deacetylating) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009236">
        <property type="term" value="P:cobalamin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd11643">
        <property type="entry name" value="Precorrin-6A-synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.950.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1010.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000878">
        <property type="entry name" value="4pyrrol_Mease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035996">
        <property type="entry name" value="4pyrrol_Methylase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014777">
        <property type="entry name" value="4pyrrole_Mease_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014776">
        <property type="entry name" value="4pyrrole_Mease_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012797">
        <property type="entry name" value="CobF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00590">
        <property type="entry name" value="TP_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036525">
        <property type="entry name" value="CobF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53790">
        <property type="entry name" value="SSF53790"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02434">
        <property type="entry name" value="CobF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="TP_methylase" evidence="5">
        <location>
            <begin position="8"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PJN10974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="261" mass="29091" checksum="61CC3F77DA95B8B2" modified="2018-04-25" version="1">MTTEQRRILVIGIGAGDPDHLTLGAVKAIRQADVFFIVGKGPDKSALTDLRHSMLEEHAEAPYRVVEVEDPSRDRRPRDRSDYTTVVQDWRSRRGDIFEGLMRDEMAEGETGAFLVWGDPSLYDSTLGILSDIEARASFSVAVEVVPGISSVSTLAAKHRIPLNQVGRPLHITPARRLPDVGQNDDGDIVVMLDAHESFTQVEGDDVWIYWGAYLGTPDELLVAGPLHEVSDRIRQVRAEARERHGWIMDTYLLRIVDSPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JVV1</accession>
    <name>A0A2M9JVV1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CG723_08580</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN11033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN11033">
        <property type="protein sequence ID" value="PJN11033"/>
        <property type="gene ID" value="CG723_08580"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PJN11033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="82" mass="8977" checksum="8A343D947722BC41" modified="2018-04-25" version="1">MHITPTTAHPTGQWAVQQAREATRALAEHGEQVRYLLRDRGAKYTASLDAVFTAEDVDILLSAPRAPKMNLVAQRIAPAALK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JW21</accession>
    <name>A0A2M9JW21_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_08780</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN11059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN11059">
        <property type="protein sequence ID" value="PJN11059"/>
        <property type="gene ID" value="CG723_08780"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="94"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN11059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="125" mass="13461" checksum="9909B519D0134580" modified="2018-04-25" version="1">MRAARPGGQSAWSSPIRLKPSALSIVALTVSGRTAGERPHRLQGRREGLGGHVGLGGPGVLAVDGWVPFAAAHRATPLTIVQIRRHLSNRAVDEVTRQEVRPRTRRCRSAREKRPVSTAQPVNVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JW74</accession>
    <name>A0A2M9JW74_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Gas vesicle protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CG723_08375</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CB01635</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">May play a structural or regulatory role in gas vesicle synthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Vacuole</location>
            <location evidence="2">Gas vesicle</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Vesicle</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN11007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN11007">
        <property type="protein sequence ID" value="PJN11007"/>
        <property type="gene ID" value="CG723_08375"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031411">
        <property type="term" value="C:gas vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005773">
        <property type="term" value="C:vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031412">
        <property type="term" value="P:gas vesicle organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009430">
        <property type="entry name" value="Gas-vesicle_GvpL/GvpF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36852">
        <property type="entry name" value="PTHR36852"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06386">
        <property type="entry name" value="GvpL_GvpF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0304">Gas vesicle</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0926">Vacuole</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004373"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PJN11007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="249" mass="26652" checksum="20D86DA8AA7ACF4E" modified="2018-04-25" version="1">MTTDGVYVYAIIRAGRPLPTDSSGVGSPAAHLRVIRQGRVAAVVSEAPANLRARRRDLLAHQELLLRLTGQGPVLPMRFGMVAPDEAAVRDQLAACEADHVAVLEHLADGVEVNVKAFPAQNALRSLLAEDKNVRRLRDEARHRPGYEANVRLGEAVASALESRAAAAGRQVLRELTSKARAVASGPEVHGCVLNVSFLVGRGDSDGFRSTAEQFAEAHRERVELRLAGPLPCYSFVSAEGTSVRTVGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JWH0</accession>
    <name>A0A2M9JWH0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_09640</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN11199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN11199">
        <property type="protein sequence ID" value="PJN11199"/>
        <property type="gene ID" value="CG723_09640"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020042">
        <property type="entry name" value="DUF4311"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14188">
        <property type="entry name" value="DUF4311"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03580">
        <property type="entry name" value="EF_0832"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="112"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="152"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="182"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="213"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN11199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="263" mass="27576" checksum="9E8B081A071E2722" modified="2018-04-25" version="1">MNETLTIALESMVIGALIGFGASAGVARMFHAPKVQGMGAFRTLGELNACENDPVAHFSFGLGFFFNAWASAVGTGALTSDVDHRIVPHWAAALSMTKNRNLDETLHNPRRMAAYGAGVGLVLVTVLNTTAASIPHSLQHVAADVLGPASEWLINPVMPIVFWMAAVDAGRRSGGWGTVLGGLAHVVMGNAVPGIVLGIVVGKGIDDLGWTRVTKALAGAVVLLFVGSAFLRGVDIQLLQQMKADVPHWLSRLHDATGTTPTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JWV8</accession>
    <name>A0A2M9JWV8_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Peroxynitrite isomerase</fullName>
            <ecNumber evidence="1">5.99.-.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Ferric nitrobindin</fullName>
            <shortName evidence="1">Nb(III)</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CG723_10590</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CB01635</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Heme-binding protein able to scavenge peroxynitrite and to protect free L-tyrosine against peroxynitrite-mediated nitration, by acting as a peroxynitrite isomerase that converts peroxynitrite to nitrate. Therefore, this protein likely plays a role in peroxynitrite sensing and in the detoxification of reactive nitrogen and oxygen species (RNS and ROS, respectively). Is able to bind nitric oxide (NO) in vitro, but may act as a sensor of peroxynitrite levels in vivo.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>peroxynitrite = nitrate</text>
            <dbReference type="Rhea" id="RHEA:63116"/>
            <dbReference type="ChEBI" id="CHEBI:17632"/>
            <dbReference type="ChEBI" id="CHEBI:25941"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </cofactor>
        <text evidence="1">Binds 1 heme b group per subunit, that coordinates a highly solvent-exposed Fe(III) atom.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Nitrogen metabolism.</text>
    </comment>
    <comment type="domain">
        <text evidence="1">Forms a 10-stranded antiparallel beta-barrel structure able to accommodate a hydrophobic ligand in its interior. In fact, this fold hosts the heme group, which is located in a wide surface cleft.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the nitrobindin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.99.-.-" evidence="1"/>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN11364.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN11364">
        <property type="protein sequence ID" value="PJN11364"/>
        <property type="gene ID" value="CG723_10590"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00034">
        <property type="reaction ID" value="UER00027"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0062213">
        <property type="term" value="F:peroxynitrite isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07828">
        <property type="entry name" value="lipocalin_heme-bd-THAP4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.128.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01297">
        <property type="entry name" value="nitrobindin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012674">
        <property type="entry name" value="Calycin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022939">
        <property type="entry name" value="Nb(III)_bact/plant"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045165">
        <property type="entry name" value="Nitrobindin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014878">
        <property type="entry name" value="THAP4-like_heme-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15854">
        <property type="entry name" value="PTHR15854"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08768">
        <property type="entry name" value="THAP4_heme-bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50814">
        <property type="entry name" value="SSF50814"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0349">Heme</keyword>
    <keyword evidence="1" id="KW-0408">Iron</keyword>
    <keyword evidence="1" id="KW-0413">Isomerase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="THAP4_heme-bd" evidence="3">
        <location>
            <begin position="26"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="GXWXGXG" evidence="1">
        <location>
            <begin position="34"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="46"/>
        </location>
        <ligand>
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="138"/>
        </location>
        <ligand>
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </ligand>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="1">
        <location>
            <position position="171"/>
        </location>
        <ligand>
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01297"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PJN11364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="180" mass="19680" checksum="648D05BB3D2F1E47" modified="2018-04-25" version="1">MYDPAPAHPYPDSTSPDEAPAPHPLLAPVLGLLGIWRGRGQGGYPTLEGEFTYAQEITFSHDGRPFLRFEARAWLLDADGAPLRPSARESGWWRLQPEGRVESLITQPTGIAEISVGTADGNTVDLSTDQVALTPTAKEVKATRRRYALTDDGTLTFTHDLEAVGMPLQHHLSAQLRRVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JWY2</accession>
    <name>A0A2M9JWY2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CG723_10620</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN11369.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN11369">
        <property type="protein sequence ID" value="PJN11369"/>
        <property type="gene ID" value="CG723_10620"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031460">
        <property type="term" value="P:glycine betaine transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005892">
        <property type="entry name" value="Gly-betaine_transp_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="SSF54631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01186">
        <property type="entry name" value="proV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="2"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="35"/>
            <end position="42"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PJN11369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="387" mass="42011" checksum="0D5FC74C1EB8AEF5" modified="2018-04-25" version="1">MIRFDQVTKRYADGTMAVDDLTFEVGEGELVTLVGPSGCGKTTTMLMVNRLIEPTSGRIFVDGEDISEVDPVKLRRRIGYVIQQVGLFPHRTILDNTATVPALIGWKKSRARARAAELLDLVGLDPKLYGSRYPEQLSGGQRQRVGVARALAADPPVLLMDEPFGAVDPVVREQLQDEFLRMQAAVRKTVLLVTHDIEEAVRLGDRIAVYGQGRIEQFDTPGAVLGTPATPYVAEFVGADRGLKRLSVTEIEPDDLDQPAVARAGEPARDAAARLRDEDARWAVVLDADGDLHGWVGIDEVSLAGEDELVGDLAHRMNAWVPVGAPLKQAFGVMLQHDAGWVAVLDGARFLGVLTPAKLHEALRRSVDADARGVARDEVSFDSVADA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-09-29" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JX34</accession>
    <name>A0A2M9JX34_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">MFS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CG723_10975</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CB01635</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN11429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN11429">
        <property type="protein sequence ID" value="PJN11429"/>
        <property type="gene ID" value="CG723_10975"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="51"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="77"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="100"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="143"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="170"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="220"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="253"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="289"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="313"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="352"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="388"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="1"/>
            <end position="417"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PJN11429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="436" mass="46818" checksum="AC74C11DD1564300" modified="2018-04-25" version="1">MIRMNKAQKWLSFLALSMTGGIIFQVAYIRFVYLEPTYTALNLSSQQYGNIISAFGAVAIVMYFFGGWFSDKFSPKLLIVISLVGMGIADIYLATVPGFWGIVAAHILMAVVGMGLYWSALVKSISVLGDSGEQGRLFGFLEGTRGIVSTAIGFIGTAVVSASVVPAHGVLTLIRIYGVLSFVFAAIVWFVVREDKTRLAGLDSATVTLKQLLAAARNRYTWLIGGTAMLMYCFYTTLGYFSPLLQDNYGVSASMIAVIGVVRSYVFQFVAGPAGGVVVDKVTRSSAVFLRWMFAGSAVLAVLFLVLPRTTALAWLALVMMFVLCALVFASRGVYWSTVGEVEVPEQERGGVIGLASGIAYLPDAFLPSLCAWWIGDSSASPTVPEQGGGYSALFVFLLAAALLGLVMTTLTARTRRRELAARHPAPVSDRVLAGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JX99</accession>
    <name>A0A2M9JX99_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">FMN reductase (NADPH)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">ssuE</name>
        <name evidence="2" type="ORF">CG723_11415</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN11503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN11503">
        <property type="protein sequence ID" value="PJN11503"/>
        <property type="gene ID" value="CG723_11415"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008752">
        <property type="term" value="F:FMN reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046306">
        <property type="term" value="P:alkanesulfonate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005025">
        <property type="entry name" value="FMN_Rdtase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020048">
        <property type="entry name" value="NADPH-dep_FMN_reduc_SsuE"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03358">
        <property type="entry name" value="FMN_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52218">
        <property type="entry name" value="SSF52218"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03567">
        <property type="entry name" value="FMN_reduc_SsuE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FMN_red" evidence="1">
        <location>
            <begin position="4"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN11503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="186" mass="19198" checksum="E3620248AB12E75D" modified="2018-04-25" version="1">MATVLSISGSPSATSRTARLLRHLDARLEAQGHDVIALDVRTLPAEALLGADFAHPAIVEATELLARADGVVVATPVYKAAYSGLLKALLDLLPQYGLDGKTVLPLATGGTTAHVLALDYALRPVLNSMGADHIVQGWFTLDKDITVAPDGTVGVAPGSAEALSRVVDQFSGALTRTARPLLAAAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JXR8</accession>
    <name>A0A2M9JXR8_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Alpha-1,4-glucan:maltose-1-phosphate maltosyltransferase</fullName>
            <shortName evidence="3">GMPMT</shortName>
            <ecNumber evidence="3">2.4.99.16</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">(1-&gt;4)-alpha-D-glucan:maltose-1-phosphate alpha-D-maltosyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">glgE</name>
        <name evidence="5" type="ORF">CG723_12380</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CB01635</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Maltosyltransferase that uses maltose 1-phosphate (M1P) as the sugar donor to elongate linear or branched alpha-(1-&gt;4)-glucans. Is involved in a branched alpha-glucan biosynthetic pathway from trehalose, together with TreS, Mak and GlgB.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 3">
            <text>[(1-&gt;4)-alpha-D-glucosyl](n) + alpha-maltose 1-phosphate = [(1-&gt;4)-alpha-D-glucosyl](n+2) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:42692"/>
            <dbReference type="Rhea" id="RHEA-COMP:9584"/>
            <dbReference type="Rhea" id="RHEA-COMP:10183"/>
            <dbReference type="ChEBI" id="CHEBI:15444"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:63576"/>
            <dbReference type="EC" id="2.4.99.16"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="2 3">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyl hydrolase 13 family. GlgE subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.99.16" evidence="3"/>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN11664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN11664">
        <property type="protein sequence ID" value="PJN11664"/>
        <property type="gene ID" value="CG723_12380"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016758">
        <property type="term" value="F:hexosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030979">
        <property type="term" value="P:alpha-glucan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02124">
        <property type="entry name" value="GlgE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026585">
        <property type="entry name" value="GlgE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021828">
        <property type="entry name" value="GlgE_dom_N/S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006047">
        <property type="entry name" value="Glyco_hydro_13_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10357:SF203">
        <property type="entry name" value="PTHR10357:SF203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11896">
        <property type="entry name" value="DUF3416"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00642">
        <property type="entry name" value="Aamy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aamy" evidence="4">
        <location>
            <begin position="201"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="region of interest" description="Maltose 1-phosphate binding" evidence="3">
        <location>
            <begin position="528"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="3">
        <location>
            <position position="388"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="3">
        <location>
            <position position="417"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="258"/>
        </location>
        <ligand>
            <name>alpha-maltose 1-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:63576"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="318"/>
        </location>
        <ligand>
            <name>alpha-maltose 1-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:63576"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="353"/>
        </location>
        <ligand>
            <name>alpha-maltose 1-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:63576"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="389"/>
        </location>
        <ligand>
            <name>alpha-maltose 1-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:63576"/>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="3">
        <location>
            <position position="474"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PJN11664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="669" mass="73923" checksum="2561D5DDB6749F0F" modified="2018-04-25" version="1">MNPGTVTGRVPIVDVLPAVDCGRRPAKAVPGETFEVSATLFGEGHAAVSANVVLRGPDGRPGPWTPMRELSPGSDRWGADVTPTAVGNWTYSVEAWGDPVSSWRRAAGIKVPAGIDTELILEEGAALHERAAAGVPEGAGRSAVLAAVDALRDEDRPPAARHAAALAPDVTAALAAHPLRENISRSAPLPLLVERERALYGAWYEMFPRSEGAVVREGERPVSGTFRTAAERLPAVAAMGFDVVYLPPIHPIGTTFRKGPNNSLSADPWDVGVPWAVGSPEGGHDAIHPDLGTLDDFDAFVRRAGELDLEIALDFALQCSPDHPWVEKHPEWFEHRSDGTIAYAENPPKKYQDIYPIAFDQDMLGLIEETSRVLRFWMRHGVRVFRVDNPHTKPVMFWERVISDINRSDPDVVFLAEAFTRPPIMRALAKAGFQQSYTYFTWRDTKQELTEYLTELSRDTAAYMRPNLFVNTPDILPRYLQKGGRRAFEVRAVLAATLSPTWGVYAGYELCENTPVREGSEEYLHSEKYELRPRDWESAEREGRSIAPLITTLNRVRRNHSALRLLRNLHFHRTDNDALIAYSKRSGPDTVVVVVNLDPHHTQEATVSLDMPQLGLDAHASVPVHDELTGETYQWGRTNFVRLEPGRAPAHILTVLRPSSPPTGGSPTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JXV3</accession>
    <name>A0A2M9JXV3_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">OpuAC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CG723_12485</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN11678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN11678">
        <property type="protein sequence ID" value="PJN11678"/>
        <property type="gene ID" value="CG723_12485"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007210">
        <property type="entry name" value="ABC_Gly_betaine_transp_sub-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04069">
        <property type="entry name" value="OpuAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014929075" description="OpuAC domain-containing protein" evidence="2">
        <location>
            <begin position="23"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="domain" description="OpuAC" evidence="3">
        <location>
            <begin position="33"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PJN11678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="298" mass="32694" checksum="9E1353E0E41F2FDA" modified="2018-04-25" version="1">MRRRTLLTGSLAVAAAAGVSTAAGSVAGTGPVITVGSKQFTESWVMGELYAQILTARGFQVVLKSNIGSADIIDRALRSHQIDLYPEYTGVILQTFAMPKRMPVTAHGTYEAAKRFEEGRGLTLLRPTPFQNRNAVAVRTSDARKHGLRTVGDLRRMGRISYAEYPDNITGPLGYDAIVKAYRLSAMKVRPLNIGLQYPALNNGDVDAADVFTTDPQLRRYDFTVLEDDQAIFGFQNVSPVVRRSLVERYGSRLTEPLDAVNALLTEKAMQALNEAAAMMRLSPAKVADRFLRANDLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JXW1</accession>
    <name>A0A2M9JXW1_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Elongation factor G</fullName>
            <shortName evidence="6">EF-G</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6 8" type="primary">fusA</name>
        <name evidence="8" type="ORF">CG723_12660</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CB01635</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN11709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN11709">
        <property type="protein sequence ID" value="PJN11709"/>
        <property type="gene ID" value="CG723_12660"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd16262">
        <property type="entry name" value="EFG_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03713">
        <property type="entry name" value="EFG_mtEFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00054_B">
        <property type="entry name" value="EF_G_EF_2_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041095">
        <property type="entry name" value="EFG_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009022">
        <property type="entry name" value="EFG_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035647">
        <property type="entry name" value="EFG_III/V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035649">
        <property type="entry name" value="EFG_V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000640">
        <property type="entry name" value="EFG_V-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004161">
        <property type="entry name" value="EFTu-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031157">
        <property type="entry name" value="G_TR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004540">
        <property type="entry name" value="Transl_elong_EFG/EF2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005517">
        <property type="entry name" value="Transl_elong_EFG/EF2_IV"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00679">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14492">
        <property type="entry name" value="EFG_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03764">
        <property type="entry name" value="EFG_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03144">
        <property type="entry name" value="GTP_EFTU_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00838">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00889">
        <property type="entry name" value="EFG_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="SSF50447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54980">
        <property type="entry name" value="SSF54980"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00484">
        <property type="entry name" value="EF-G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00301">
        <property type="entry name" value="G_TR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 6 8" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="5 6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4 6" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="7">
        <location>
            <begin position="14"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="23"/>
            <end position="30"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="87"/>
            <end position="91"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="141"/>
            <end position="144"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PJN11709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="699" mass="74668" checksum="22E087EA9ADD1D67" modified="2018-04-25" version="1">MRTDLHRHDTDPLTAVRNVGILAHVDAGKTTVTERILYVTGATYKRGEVHDGTTVTDFDVQERERGITISAAAVSCAWDGHRINLIDTPGHVDFADEVERSLRVLDGAIAVFDAVAGVEPQSESVWRQADRHGVPRIAFVNKLDRAGADLDTAVESMRRRLDTVPMVVQLPVGREDAFTGVVDLIRMRLLVWREGHDTYEEGPVPVELREEARRRRRLLEETVAQLHPGALEEFCDGSALSAGTLAGALRDLTRSGEGVVVLCGSAYRNRGVEPLLDAVVAYLPSPLDVPAVRGAVGDDEQERACDPTAPLAALVFKVQATPRGRLTYLRVYSGTVHRGEAVWDAGARRTERIGRILRVQADRHTEVERAVAGDIVAVAGVKAARSGATLCAPDAPVVLEPPTVAEPVVSVAVEARRNADSARLVSALARLVEEDPSLVVRTDRESGQTVLSGMGELHLEVAVEKIRRAHGLEVGVGRPQVAYRETVARGVSGLVYRHVKQEGGAGQFAHVVIDVRPLPVAQDDTGDGAADFVFRSVVTGGRLPRDYVQAVEAGCRDALSEGPLGGHRVTGVQVTLTDGSTHPKDSSPMAFRTAGRSALRAAFRASVMALLEPVVDVTATVPEDAVGGVLGDLAARRGQISASAMRAGTAVVTATVPLAELFGYASQLRGRTQGRGTFTSRATGYAPVPGEVSDQVVPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JXX9</accession>
    <name>A0A2M9JXX9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Short-chain dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_12740</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN11721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN11721">
        <property type="protein sequence ID" value="PJN11721"/>
        <property type="gene ID" value="CG723_12740"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN11721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="235" mass="24384" checksum="10601C48F8592632" modified="2018-04-25" version="1">MTKTLITGANKGLGFETARRLIAAGHTVYVGSRDAERGRRAAEQLGARRVQLDVTDDASVNAAAKTIEADGGLDVLINNAGIEGRTPDGGVIGAADVTADEMRSTFETNVFGVVRVTHAFLPLLQKSNAPVVVNLSSGLASLARVTDAGTPTHAYPGVAYPASKAAVNMITVQYAKAFPGMRINAVEPGYTATDLNAHTGIQTVEEGAEIIVRMAQLGPDGPTGTYVAAEGPLPW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JY07</accession>
    <name>A0A2M9JY07_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcriptional repressor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_13000</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Fur family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN11765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN11765">
        <property type="protein sequence ID" value="PJN11765"/>
        <property type="gene ID" value="CG723_13000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07153">
        <property type="entry name" value="Fur_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002481">
        <property type="entry name" value="FUR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043135">
        <property type="entry name" value="Fur_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33202">
        <property type="entry name" value="PTHR33202"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01475">
        <property type="entry name" value="FUR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN11765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="136" mass="15050" checksum="F435FCD97A92A51A" modified="2018-04-25" version="1">MSGLLERLRGRGWRMTSQRRVVAEVLDGDHVHLTADEVHSRAVQRLPEISRATVYNALGELVALGEVIEVSTDGRAKRYDPNAHRPHQHLVCSSCGIIRDVHPTGDPLSGLPAQERFGFRVSKVEVTYRGLCPSCA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JY60</accession>
    <name>A0A2M9JY60_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CG723_13240</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN11804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN11804">
        <property type="protein sequence ID" value="PJN11804"/>
        <property type="gene ID" value="CG723_13240"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PJN11804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="338" mass="36179" checksum="4FA739DC77A8AA71" modified="2018-04-25" version="1">MNEDKESRAAVPTLPTLELRHHAVIAGEDGEEQVAASVGPDGQVIALWSKPRDVAGLSATTTGPGGATFPEPRAAKAVDARVTVHAPHPTASVELPGLELAHVTVQPLPGARVLVVGARTRWRPEGADRNAIVYDADGRVVAEATLGDGISHVFTTHTGDIWVGYFDEGVYGNLGWGNPGTPAPMGQYGLTRFSSDLETQWHFPSHTSEPWGAISDCYALNIDGDAAWACYYTDFPIVRIRDGVVTSWHNSVAGATALAVQDSRVALLGGYGPHHDRLSVGTLDSEELRITAEYRIVLPNGDPLPKYTQVIGRGPDLHVLSGNDWYRLSLRDIPHGAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-09-29" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JZ11</accession>
    <name>A0A2M9JZ11_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ni/Fe hydrogenase formation protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_14395</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HupF/HypC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN11997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN11997">
        <property type="protein sequence ID" value="PJN11997"/>
        <property type="gene ID" value="CG723_14395"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019812">
        <property type="entry name" value="Hydgase_assmbl_chp_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001109">
        <property type="entry name" value="Hydrogenase_HupF/HypC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35177">
        <property type="entry name" value="PTHR35177"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01455">
        <property type="entry name" value="HupF_HypC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00445">
        <property type="entry name" value="HUPFHYPC"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00074">
        <property type="entry name" value="hypC_hupF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01097">
        <property type="entry name" value="HUPF_HYPC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN11997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="106" mass="11800" checksum="5CF8948E632098DA" modified="2018-04-25" version="1">MCLAVPGRVTEIEDRDGTRMATVDFGGVVKEVCLEYLPDLQVGEYAIVHVGFALQKLDEESARQTLELFENLGMLQEEFGDPWELAAEASGPQWADDEEVPQEAQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JZ12</accession>
    <name>A0A2M9JZ12_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_08715</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN12098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN12098">
        <property type="protein sequence ID" value="PJN12098"/>
        <property type="gene ID" value="CG723_08715"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008160">
        <property type="entry name" value="Collagen"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01391">
        <property type="entry name" value="Collagen"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="44"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN12098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="77" mass="7413" checksum="A551F273EA8C65E3" modified="2018-04-25" version="1">MQIDDLRMQPVDVQASVKPGPSGPSGPPGPSGPVGPIGPAGKDGTDGKDGKEGTNGRDGTAGKDGKDAVAPPAPDPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JZB4</accession>
    <name>A0A2M9JZB4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_13375</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN12206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN12206">
        <property type="protein sequence ID" value="PJN12206"/>
        <property type="gene ID" value="CG723_13375"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021941">
        <property type="entry name" value="DUF3556_TM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12077">
        <property type="entry name" value="DUF3556"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="23"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="173"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN12206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="198" mass="21964" checksum="05E6BE373A8468F8" modified="2018-04-25" version="1">MATVAVLGLRDKTIFLAARGEQYWLSLLIFFFPCSGMFIGFKLVMLALWWGAATSKLNRHFPFVVATMMSNAPLIPSGRVKRVFYRDHPRDLRSSRLPLLLARIGTAARCGFAPGEVRVICLESQPIHRQNQTYEVHDAALGLLERGHVKVHDMVTRQPWPTDGPGYPVYGVQSGHPLRPVPDADGSVEGLPPMDTAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JZL7</accession>
    <name>A0A2M9JZL7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_04475</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000002">
        <property type="protein sequence ID" value="PJN12316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN12316">
        <property type="protein sequence ID" value="PJN12316"/>
        <property type="gene ID" value="CG723_04475"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021214">
        <property type="entry name" value="DUF2568"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10823">
        <property type="entry name" value="DUF2568"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="32"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN12316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="109" mass="11423" checksum="A60C984CD19C0022" modified="2018-04-25" version="1">MKTANLGVLFLIELAALGAVGRWGFTRDVSAPLAWLLGLGVIAVMITLWALFGSQKASYKTRGAGRVAFELVWFGAGAAALLLAGAVGWAVAYVLVCGVSKTLAVVWRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-06-02" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JZN5</accession>
    <name>A0A2M9JZN5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">TetR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_04635</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000002">
        <property type="protein sequence ID" value="PJN12345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN12345">
        <property type="protein sequence ID" value="PJN12345"/>
        <property type="gene ID" value="CG723_04635"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06974">
        <property type="entry name" value="TerD_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003325">
        <property type="entry name" value="TerD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02342">
        <property type="entry name" value="TerD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TerD" evidence="2">
        <location>
            <begin position="1"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="178"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="188"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="214"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="244"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN12345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="309" mass="32281" checksum="E0718B3F6CF2EFB7" modified="2018-04-25" version="1">MTHAMLKGSNVPLEATAVRAVLRWAIGQGVPDVDASALLLGPDGRVRSDEDFVFYNQPRHPSGKVWRLGKKRVADGLTDTIQSDLAGLGPEVGRVLLVASADDVPFDHVPALRILIYDAAAAEGEPLARFDVKPETGAETALICGELYRRGEGWKFRALGEGYSNGLVGLATDFGISVDESEPAPDLQASSPPGPMPAAEPSFPPPAPDTSFMGSGSDWGSGSGSGSGSGYGYPQAPTQQPIAASLPQPAPQPVSQPSYGYPPAAPTQPAPLVMPVPTTQPAYGYPQPVQPLPDPNFALPPQGPQFISR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JZY9</accession>
    <name>A0A2M9JZY9_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">2-dehydro-3-deoxy-phosphogluconate aldolase</fullName>
            <ecNumber evidence="3">4.1.2.14</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CG723_05165</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CB01635</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>2-dehydro-3-deoxy-6-phospho-D-gluconate = D-glyceraldehyde 3-phosphate + pyruvate</text>
            <dbReference type="Rhea" id="RHEA:17089"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:57569"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="4.1.2.14"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the KHG/KDPG aldolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.2.14" evidence="3"/>
    <dbReference type="EMBL" id="NNBL01000002">
        <property type="protein sequence ID" value="PJN12434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN12434">
        <property type="protein sequence ID" value="PJN12434"/>
        <property type="gene ID" value="CG723_05165"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008675">
        <property type="term" value="F:2-dehydro-3-deoxy-phosphogluconate aldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd00452">
        <property type="entry name" value="KDPG_aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000887">
        <property type="entry name" value="Aldlse_KDPG_KHG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031337">
        <property type="entry name" value="KDPG/KHG_AS_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031338">
        <property type="entry name" value="KDPG/KHG_AS_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30246">
        <property type="entry name" value="PTHR30246"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01081">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01182">
        <property type="entry name" value="eda"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00159">
        <property type="entry name" value="ALDOLASE_KDPG_KHG_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00160">
        <property type="entry name" value="ALDOLASE_KDPG_KHG_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0456">Lyase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000654"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PJN12434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="206" mass="20945" checksum="FB667DCFE5E00F0A" modified="2018-04-25" version="1">MTDSSVLDLAPVVPVVVVEDIADAVPLARALVAGGLRAIEVTLRTPAALDAIRAVADEVPDAVVGAGTVISPQNVADSVAAGARFLVSPGWTDTLLDAMKKSGVPFLPGVSTTSEVVALLERGVSEMKFFPAQAAGGVPYLKSLAGPLPQARFCPTGGVSLSSAPSYLALENVGCVGGSWMLPADAVAAKDWARIETLAREAAGLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-05-25" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K080</accession>
    <name>A0A2M9K080_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Zn-dependent alcohol dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CG723_05125</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CB01635</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000002">
        <property type="protein sequence ID" value="PJN12427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN12427">
        <property type="protein sequence ID" value="PJN12427"/>
        <property type="gene ID" value="CG723_05125"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="PKS_ER"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="PKS_ER" evidence="3">
        <location>
            <begin position="10"/>
            <end position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PJN12427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="358" mass="37136" checksum="A3AA30FCBF453A42" modified="2018-04-25" version="1">MRAAVLHEIGQDKLEVLDDVEAVGFGPGKVRIRVRATGLCHSDVSAMNGVLPQPAPFIPGHEGAGEILDVGDGVTNVKPGDRVLVCWLPACGACPACKRGQTQLCLAGFMNAGTPNFKRPGGDVFGFAGTGTFTEEVVVDAGCAVPIPDDVPFDIAALIGCGVTTGLGAAINTADVAAGSSVAVIGCGGVGISAIQGARLKGAAQIVAVDPVESRREAALKFGATEAVAPDALGDAKQRITAGEGFDYVFEVVGKSATARTAYETTRRGGTLCVVGAGALDDFLQLNMFELFFDEKKILPSMYGGGDVLTSYERAIALWRAGRIDLESLITHRVQLAEINEALDQMRTGTALRTCIEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-05-25" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K0A3</accession>
    <name>A0A2M9K0A3_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Cytochrome c oxidase subunit 1</fullName>
            <ecNumber evidence="9">7.1.1.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">ctaD</name>
        <name evidence="12" type="ORF">CG723_05885</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">CB01635</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6 9">Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7 9">
            <text>4 Fe(II)-[cytochrome c] + 8 H(+)(in) + O2 = 4 Fe(III)-[cytochrome c] + 4 H(+)(out) + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:11436"/>
            <dbReference type="Rhea" id="RHEA-COMP:10350"/>
            <dbReference type="Rhea" id="RHEA-COMP:14399"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="EC" id="7.1.1.9"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 9">Energy metabolism; oxidative phosphorylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cell membrane</location>
            <topology evidence="9">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the heme-copper respiratory oxidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.1.1.9" evidence="9"/>
    <dbReference type="EMBL" id="NNBL01000002">
        <property type="protein sequence ID" value="PJN12562.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN12562">
        <property type="protein sequence ID" value="PJN12562"/>
        <property type="gene ID" value="CG723_05885"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00705"/>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070469">
        <property type="term" value="C:respirasome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004129">
        <property type="term" value="F:cytochrome-c oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015990">
        <property type="term" value="P:electron transport coupled proton transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006119">
        <property type="term" value="P:oxidative phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.210.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023616">
        <property type="entry name" value="Cyt_c_oxase-like_su1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036927">
        <property type="entry name" value="Cyt_c_oxase-like_su1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000883">
        <property type="entry name" value="Cyt_C_Oxase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023615">
        <property type="entry name" value="Cyt_c_Oxase_su1_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014241">
        <property type="entry name" value="Cyt_c_oxidase_su1_bac"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10422">
        <property type="entry name" value="PTHR10422"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00115">
        <property type="entry name" value="COX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01165">
        <property type="entry name" value="CYCOXIDASEI"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81442">
        <property type="entry name" value="SSF81442"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02891">
        <property type="entry name" value="CtaD_CoxA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50855">
        <property type="entry name" value="COX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00077">
        <property type="entry name" value="COX1_CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-0186">Copper</keyword>
    <keyword evidence="8" id="KW-0249">Electron transport</keyword>
    <keyword evidence="8" id="KW-0349">Heme</keyword>
    <keyword evidence="9" id="KW-0408">Iron</keyword>
    <keyword evidence="5 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="47"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="86"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="127"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="175"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="212"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="258"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="294"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="321"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="364"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="397"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="434"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="476"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="domain" description="COX1" evidence="11">
        <location>
            <begin position="35"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="558"/>
            <end position="578"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00025218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00029368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU363061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50855"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PJN12562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="578" mass="63981" checksum="FC6EA9705742772B" modified="2018-04-25" version="1">MSILNEPQGAAAADDSYENELPVRRKQPGNVVVKWLTTTDHKTIGTLYLVTSFAFFCIGGVMALFMRAELARPGNQIMSNEQFNQAFTMHGTIMLLMFATPLFAGFTNWIMPLQIGAPDVAFPRLNMFAYWLYLFGSTIAVGGFLTPQGAADFGWFAYSPLSDAVRSPGIGADMWIMGLAFSGFGTILGAVNFITTIICMRAPGMTMFRMPIFVWNVLLTAVLVLLAFPVLAAALFALEADRKFGAHVFDASNGGALLWQHLFWFFGHPEVYIIALPFFGIISEVIPVFSRKPMFGYSGLIGATIAIAGLSVTVWAHHMYVTGGVLLPFFSFMTFLIAVPTGVKFFNWIGTMWKGSLSFETPMLWTIGFLITFVFGGLTGVILAAPPLDFHVSDSYFVVAHFHYVVFGTVVFAMFAGFHFWWPKFTGKMLDERLGKITFWTLFIGFHGTFLVQHWLGVEGMPRRYADYLAADGFTALNTISTISSFLLGLSILPFFYNVWKTAKYGKKVEVDDPWGYGRSLEWATSCPPPRHNFLTLPRIRSESPAFDLHHPEIAAMDQLQNGGHGGKALSGGKEAGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K0G9</accession>
    <name>A0A2M9K0G9_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Methylenetetrahydrofolate reductase</fullName>
            <ecNumber evidence="10">1.5.1.20</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">metF</name>
        <name evidence="11" type="ORF">CG723_06130</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CB01635</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2 10">
            <text>(6S)-5-methyl-5,6,7,8-tetrahydrofolate + NAD(+) = (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + H(+) + NADH</text>
            <dbReference type="Rhea" id="RHEA:19821"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15636"/>
            <dbReference type="ChEBI" id="CHEBI:18608"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.5.1.20"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>(6S)-5-methyl-5,6,7,8-tetrahydrofolate + NADP(+) = (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:19817"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15636"/>
            <dbReference type="ChEBI" id="CHEBI:18608"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.5.1.20"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3 10">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4 10">One-carbon metabolism; tetrahydrofolate interconversion.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5 10">Belongs to the methylenetetrahydrofolate reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.5.1.20" evidence="10"/>
    <dbReference type="EMBL" id="NNBL01000002">
        <property type="protein sequence ID" value="PJN12606.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN12606">
        <property type="protein sequence ID" value="PJN12606"/>
        <property type="gene ID" value="CG723_06130"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00193"/>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106312">
        <property type="term" value="F:methylenetetrahydrofolate reductase NADH activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106313">
        <property type="term" value="F:methylenetetrahydrofolate reductase NADPH activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009086">
        <property type="term" value="P:methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035999">
        <property type="term" value="P:tetrahydrofolate interconversion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00537">
        <property type="entry name" value="MTHFR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029041">
        <property type="entry name" value="FAD-linked_oxidoreductase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003171">
        <property type="entry name" value="Mehydrof_redctse-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004620">
        <property type="entry name" value="MTHF_reductase_bac"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02219">
        <property type="entry name" value="MTHFR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51730">
        <property type="entry name" value="SSF51730"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00676">
        <property type="entry name" value="fadh2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0274">FAD</keyword>
    <keyword evidence="6 10" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="9" id="KW-0520">NAD</keyword>
    <keyword evidence="8 10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00006743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PJN12606.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="306" mass="33519" checksum="79A08BD4BCD870CB" modified="2018-04-25" version="1">MALGTASTRTDRARTVRDMLATGKTTFSFEFSAPKTPKGERNLWNALRRVEAVAPDFVSVTYGAGGSTRAGTVRETEQIVADTTLTPVAHLTAVDHSVAQLRNIIGQYADAGIRNILAVRGDPPGDPMADWVAHPEGLTYAAELVRLIKESGDFCVGVAAFPAMHPRSEDWDSDVRHFVDKCRAGADYAITQMFFYPEEYLRLRDRVEAAGCDTPVIPEIMPVTSVRMLERLPQLSNATFPPALKERILTAKDDPAAVRSIGIEFATEFCAKLLDEGVPGLHFITLNNSTATLEIYENLGLHDQRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K0J7</accession>
    <name>A0A2M9K0J7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">TIGR03085 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_06445</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000002">
        <property type="protein sequence ID" value="PJN12661.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN12661">
        <property type="protein sequence ID" value="PJN12661"/>
        <property type="gene ID" value="CG723_06445"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017517">
        <property type="entry name" value="CHP03083_actinobac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017519">
        <property type="entry name" value="CHP03085"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034660">
        <property type="entry name" value="DinB/YfiT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024344">
        <property type="entry name" value="MDMPI_metal-binding"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11716">
        <property type="entry name" value="MDMPI_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109854">
        <property type="entry name" value="SSF109854"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03083">
        <property type="entry name" value="TIGR03083"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03085">
        <property type="entry name" value="TIGR03085"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MDMPI_N" evidence="1">
        <location>
            <begin position="12"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF11716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN12661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="211" mass="23516" checksum="134401F393150476" modified="2018-04-25" version="1">MSTHAKRERLLLADLLEASGPDAPTLCEGWNARDLAAHVVVRERRADAAGGIVIKQLAQRLERVQAEFAEKPFDELIQLIRTGPPRFSPFSLKQIDEASNAVEFFVHTEDVRRAQPDWTPRELDPVFADVLWSRLERMARVIGRKSPVGLVLRRPDGRTVVAHKGTPVVTVTGEPSELLMFAFGRQDAARVETEGEKDAIGKLHEAKQLGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K0Y2</accession>
    <name>A0A2M9K0Y2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Ionic transporter y4hA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CG723_07145</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CB01635</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000002">
        <property type="protein sequence ID" value="PJN12779.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN12779">
        <property type="protein sequence ID" value="PJN12779"/>
        <property type="gene ID" value="CG723_07145"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004837">
        <property type="entry name" value="NaCa_Exmemb"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01699">
        <property type="entry name" value="Na_Ca_ex"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="35"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="66"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="102"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="135"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="167"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="219"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="257"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="287"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="318"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="domain" description="Na_Ca_ex" evidence="6">
        <location>
            <begin position="38"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="domain" description="Na_Ca_ex" evidence="6">
        <location>
            <begin position="223"/>
            <end position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PJN12779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="366" mass="37473" checksum="038A058E8A97B702" modified="2018-04-25" version="1">MIAGLRRLVTQWTAVVPVLAVVLLVFTWGRSLPGAVVAVVSVVLAASVLAAVHHAEVVAHRVGEPFGSLVLAVAVTVIEVALIVTLMVDGGEKGATLARDTVFAAVMITCNGIVGLSLLAAAFRHRIAVFQSEGTGGALATVATLATLCLVLPTFTTSKPGPEFSTSQLIFAASAALVLYGIFVATQTVRHRDYFLPITKQGNVIDGDDHADAPTTRTALISLGFLGLALVAVVGLAKGVSPTIESGVEAAGMPHSVVGVIIALLVLLPETIAALRAARRDRVQTSLNLALGSAMASIGLTIPAVAIASFWLSGPLVLGLGATQMVLLVLTMLVSTLTVVPGRATPLQGGVHLVVFAAYVELAVTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K0Y4</accession>
    <name>A0A2M9K0Y4_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">MHYT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CG723_07120</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000002">
        <property type="protein sequence ID" value="PJN12774.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN12774">
        <property type="protein sequence ID" value="PJN12774"/>
        <property type="gene ID" value="CG723_07120"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005330">
        <property type="entry name" value="MHYT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03707">
        <property type="entry name" value="MHYT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50924">
        <property type="entry name" value="MHYT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="46"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="85"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="111"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="142"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="173"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="215"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="domain" description="MHYT" evidence="3">
        <location>
            <begin position="10"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="247"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PJN12774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="268" mass="27825" checksum="5AEABF8688C72510" modified="2018-04-25" version="1">MQGTVDGFSYGLVTPLVAFFMACLGGALGLRCTTRSLLVTQSWRPGWLALGSAAIGSGIWTMHFIAMMGFRVQGTPIHYDKPTTFASLGVAIVMVGIGIFIVGYRGATGTALFTGGTVTGLGVASMHYLGMAGMRLHGTLQYNTFTVGVSVVIAMAAATAALWAAVQVRGFSWSVGASLVMGLAVTGMHYTGMAALRVHTHASGGTPPGDAPAELLAPLMIGPLCFLLLAGVVVVFDPMMMTGRPDRRDAVEAASRAGRTVRPLRRAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K157</accession>
    <name>A0A2M9K157_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Histidine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_07585</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000002">
        <property type="protein sequence ID" value="PJN12865.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN12865">
        <property type="protein sequence ID" value="PJN12865"/>
        <property type="gene ID" value="CG723_07585"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011712">
        <property type="entry name" value="Sig_transdc_His_kin_sub3_dim/P"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07730">
        <property type="entry name" value="HisKA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="53"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="108"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="158"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="domain" description="HisKA_3" evidence="2">
        <location>
            <begin position="215"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN12865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="417" mass="43281" checksum="94DF73907DE7F902" modified="2018-04-25" version="1">MRGFWSALFGRRARRRWIHLILGGALAMPYVLVGSVVIGSLTGVSDVFTSLTLQLGSFAVGLPLAAVTALFPLTRPISVAAVRALCGVPGDALADGPPRSRAARGRTVAWFTLHLGFGGVLSGMTLALPPFAVTLMVLPLFAGLRDSALALPEVLHHAWALALAPVAGAAMLVALAGCAAVAGALLARWAPVLLGPTPADRLVVAERRAADLALRNRLARELHDSVGHALSAVTLQASAARRVLYHDVEFVREALAAIEDTTRRTVGELDAVLGVLREAGDPASTAPAPTLAADLDGLLSRTRAGGLRLQADVVALDPAALPPLVSREAYRIVQEVLSNALRHAGTSLALRLARDGDDLLITAENPLPPHPPRARPGGGHGLRGIADRARLLGGAAEAGPADGAWRVSVRLPLKANA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K1A3</accession>
    <name>A0A2M9K1A3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Amidohydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_07860</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000002">
        <property type="protein sequence ID" value="PJN12912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN12912">
        <property type="protein sequence ID" value="PJN12912"/>
        <property type="gene ID" value="CG723_07860"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016831">
        <property type="term" value="F:carboxy-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032465">
        <property type="entry name" value="ACMSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21240">
        <property type="entry name" value="PTHR21240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04909">
        <property type="entry name" value="Amidohydro_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydro-rel" evidence="2">
        <location>
            <begin position="13"/>
            <end position="372"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN12912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="427" mass="47713" checksum="28C0BEEFD8543601" modified="2018-04-25" version="1">MTDQDPYLIISSDCHAGLPTEEYRPYLDSRFHRAFDEFLGERGARREEATRLGIRNDAFAAKWFADNSEGLRGGWDSAQRLKELDGDGVAAEVVFPDADAVDSRTAAPFGVGLGLSGDQDPELGMAGAQAHNRWLADFVSEHPERHCGVALLPITGEVERVVAEVHRAKESGLGALMIPSMWVDKAPYHDRRYDPVWAAAAECAMPVVTHSGAAPRHEYGDHLGIYVSEVTWWPARPLWFMLWSGVFERHPGLKFGVAESGCWWLPNLLWFMDRLYLGAHGGKKLSPFAELKRSPHEYLDRQVFICATNTKRRELAQRYEIGVDNILWGSDFPHPEGTWPDTRTWLKKTFHDIPVAETRRMLGLAAAEVFGFDTGKLAPLAARIGPTPAELGQDTDQSAVEASWARSREVGRHWLTDHDFPTLGVTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-09-29" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K1H6</accession>
    <name>A0A2M9K1H6_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Diaminobutyrate--2-oxoglutarate transaminase</fullName>
            <ecNumber evidence="5">2.6.1.76</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">DABA aminotransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">ectB</name>
        <name evidence="6" type="ORF">CG723_07645</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CB01635</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes reversively the conversion of L-aspartate beta-semialdehyde (ASA) to L-2,4-diaminobutyrate (DABA) by transamination with L-glutamate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>2-oxoglutarate + L-2,4-diaminobutanoate = L-aspartate 4-semialdehyde + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:11160"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58761"/>
            <dbReference type="ChEBI" id="CHEBI:537519"/>
            <dbReference type="EC" id="2.6.1.76"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="5">Amine and polyamine biosynthesis; ectoine biosynthesis; L-ectoine from L-aspartate 4-semialdehyde: step 1/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.76" evidence="5"/>
    <dbReference type="EMBL" id="NNBL01000002">
        <property type="protein sequence ID" value="PJN12877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN12877">
        <property type="protein sequence ID" value="PJN12877"/>
        <property type="gene ID" value="CG723_07645"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00067">
        <property type="reaction ID" value="UER00121"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045303">
        <property type="term" value="F:diaminobutyrate-2-oxoglutarate transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047307">
        <property type="term" value="F:diaminobutyrate-pyruvate transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019491">
        <property type="term" value="P:ectoine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00610">
        <property type="entry name" value="OAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005814">
        <property type="entry name" value="Aminotrans_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004637">
        <property type="entry name" value="Dat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012773">
        <property type="entry name" value="Ectoine_EctB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43552">
        <property type="entry name" value="PTHR43552"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43552:SF2">
        <property type="entry name" value="PTHR43552:SF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00202">
        <property type="entry name" value="Aminotran_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000521">
        <property type="entry name" value="Transaminase_4ab_Lys_Orn"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00709">
        <property type="entry name" value="dat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02407">
        <property type="entry name" value="ectoine_ectB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00600">
        <property type="entry name" value="AA_TRANSFER_CLASS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="3 4" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU365034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PJN12877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="423" mass="46745" checksum="BD7F9BFFC8978C87" modified="2018-04-25" version="1">MTITQPDLSVFETLESEVRSYCRGWPTIFDRAQGSRMFDEDGHEYLDFFAGAGSLNYGHNNPVLKRALIDYLERDGVTHGLDMSTTAKRAFLESFQNIILRPRDLPYKVMFPGPTGTNAVESALKLARKVKGRESIVSFTNAFHGMSLGSLAVTGNAFKRAGAGIPLVHGTPMPFDNYLDGQTPDFIWFERLLEDSGSGLNTPAAVIVETVQGEGGINVARTEWLRKLADVCKRWDMLLIVDDIQMGCGRTGAFFSFEEAGITPDIVTVSKSISGYGLPMSLCLFKPELDVWEPGEHNGTFRGNNPAFVTAAAALETYWTDGPAMEKQTLARGQQIDEALGALRDEFRDDTVEYRGRGLVWGLEFRDKDRANKVAKRAFELGLLIETSGPESEVVKLLPALTITPEELEEGLRTLTRAVRETA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K1H8</accession>
    <name>A0A2M9K1H8_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 9">Enoyl-[acyl-carrier-protein] reductase [NADH]</fullName>
            <ecNumber evidence="9">1.3.1.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CG723_07960</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">CB01635</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>a 2,3-saturated acyl-CoA + NAD(+) = a (2E)-enoyl-CoA + H(+) + NADH</text>
            <dbReference type="Rhea" id="RHEA:18177"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:58856"/>
            <dbReference type="ChEBI" id="CHEBI:65111"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="2">
            <dbReference type="Rhea" id="RHEA:18179"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 2,3-saturated acyl-[ACP] + NAD(+) = a (2E)-enoyl-[ACP] + H(+) + NADH</text>
            <dbReference type="Rhea" id="RHEA:10240"/>
            <dbReference type="Rhea" id="RHEA-COMP:9925"/>
            <dbReference type="Rhea" id="RHEA-COMP:9926"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:78784"/>
            <dbReference type="ChEBI" id="CHEBI:78785"/>
            <dbReference type="EC" id="1.3.1.9"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="1">
            <dbReference type="Rhea" id="RHEA:10242"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Lipid metabolism; mycolic acid biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 9">Belongs to the short-chain dehydrogenases/reductases (SDR) family. FabI subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.9" evidence="9"/>
    <dbReference type="EMBL" id="NNBL01000002">
        <property type="protein sequence ID" value="PJN12930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN12930">
        <property type="protein sequence ID" value="PJN12930"/>
        <property type="gene ID" value="CG723_07960"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00915"/>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004318">
        <property type="term" value="F:enoyl-[acyl-carrier-protein] reductase (NADH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016631">
        <property type="term" value="F:enoyl-[acyl-carrier-protein] reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050343">
        <property type="term" value="F:trans-2-enoyl-CoA reductase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05372">
        <property type="entry name" value="ENR_SDR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014358">
        <property type="entry name" value="Enoyl-ACP_Rdtase_NADH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43159">
        <property type="entry name" value="PTHR43159"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000094">
        <property type="entry name" value="Enoyl-ACP_rdct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="8 9" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="9" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="8 9" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7 9 11" id="KW-0520">NAD</keyword>
    <keyword evidence="6 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="11">
        <location>
            <position position="14"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="20"/>
            <end position="21"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="64"/>
            <end position="65"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="92"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="95"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="161"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="190"/>
            <end position="194"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00017755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR000094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000094-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR000094-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PJN12930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="255" mass="27069" checksum="C28858CBF5064E38" modified="2018-04-25" version="1">MSGILEGKRVLITGVLMESSIAFHAAKLAQQQGAEIILTAFPRPTLTERIAKKLPKPTKVIELDVTNDEHLGRLADVVGEELGGLDGVVHSIGFAPQDALGGNFLNTPFESVATAMHVSAFSLKSLTMACLPLMQNGGSVVGLTFDAQYAWPQYDWMGPAKAALEATNRYLARDLGKQNVRSNLISAGPIGSMAAKSIPGFSDLAAVWDSRSPLEWDLKDPEPAGKGIVALLSDWFPKTTGEIIHVDGGLHAIGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K1L2</accession>
    <name>A0A2M9K1L2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Branched-chain amino acid ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CG723_06835</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CB01635</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000002">
        <property type="protein sequence ID" value="PJN13014.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN13014">
        <property type="protein sequence ID" value="PJN13014"/>
        <property type="gene ID" value="CG723_06835"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015658">
        <property type="term" value="F:branched-chain amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06581">
        <property type="entry name" value="TM_PBP1_LivM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001851">
        <property type="entry name" value="ABC_transp_permease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043428">
        <property type="entry name" value="LivM-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30482">
        <property type="entry name" value="PTHR30482"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02653">
        <property type="entry name" value="BPD_transp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="61"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="94"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="173"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="199"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="232"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="255"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="282"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="312"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="404"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="456"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="496"/>
            <end position="521"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PJN13014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="589" mass="61558" checksum="944F63DEAF2AE48B" modified="2018-04-25" version="1">MTTQKTDTARGLITLPAGAPRVLIAAGAVATIASTFMSWTWTSDFPGDLTVYGYPAGLQTIALVAGLITLLFTLPLWNVRGLHRLNPAGATSPILLTTLAGFTVCWYAAIAIAVELGGLANLDPGAYVAAVASALPVLGALALPRPGDTAKAYLTKPDQPAPTGQLPGWTQRLIVTLGITLGLIAFTYGIGINDEESETFIGFVLLLVFVAWALVHAGQLDRFSTLCAQNKGFATGIAFLAAAIFPFTQSEDHNANLGVNILIFATVALGLNIVVGLTGLLDLGYVAFLGVGAYAAALVSGSEFSRFSGVQFPFWAAALTGMAASLVFGVLIGAPTLRLRGDYLAIVTLGFGEIFRIAVNNMDGSSGPDITNGPDGIPSIPDLEIFGFNLGASHDVAGFTLGRFANYFFLMLLITALVVLVFTRAADSRIGRSWIAIREDETAATAMGINGFRVKLIAFALGATLAGLAGTVSAHVTYSVVPSPYQFAGAAPPNSAFLLAAVVLGGMGTVSGPLLGASLLYLIPEKLTFLKEYELLAFGIALVILMRFRPEGIIANRRRQLEFHETGQLDIPEQQSLPDSTVGATKAGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K1R1</accession>
    <name>A0A2M9K1R1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">CoA-transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CG723_06665</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000002">
        <property type="protein sequence ID" value="PJN13010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN13010">
        <property type="protein sequence ID" value="PJN13010"/>
        <property type="gene ID" value="CG723_06665"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008410">
        <property type="term" value="F:CoA-transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004165">
        <property type="entry name" value="CoA_trans_fam_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01144">
        <property type="entry name" value="CoA_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00882">
        <property type="entry name" value="CoA_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="SSF100950"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PJN13010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="237" mass="25919" checksum="9A4D04D60E29FF63" modified="2018-04-25" version="1">MIACAYAWRDSGEILASPMGLIPSVGARLAKRTFSPDLLLTDGEAMTVGLDGEPEGWLPYRQHLTMVTGGRRHVMMGASQIDRHGNQNISCIGDWDRPARQLLGVRGAPVNTLNNPVSYWVPKHSARVFVEKVDMISGVGYDSAAAAGPSATRYHRIPRVVSNLGVFDFETPDRSMRLASVHPGVTVDEVIAATAFPLVLPDGGDVPYTREPTPEELRLIREVIDPKGLRDREVRPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K2T2</accession>
    <name>A0A2M9K2T2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CG723_02335</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000001">
        <property type="protein sequence ID" value="PJN13432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN13432">
        <property type="protein sequence ID" value="PJN13432"/>
        <property type="gene ID" value="CG723_02335"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PJN13432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="249" mass="24741" checksum="8878C7AB15C0F1F1" modified="2018-04-25" version="1">MASGGPMNGKAALVTGGSRGIGAATALRLAREGADVAVTYVNGKEAAEEVVRRVEALGRRGLALRADSADPHEAAGAVDQAADAFGGLDVLVNNVGVGLLGPLEGFSLAEIDHALAVNVRGVLLASQAAATRLSDGGRIVTVGTCMAKRVPGPGGTVYATTKAALIGLTKALARELGGRGITANIVHPGPIDTDMNPADGPYASGQTVSVALDRFGTADEVASMVAYLAGPEATYVTGAEFAVDGGHAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K2X4</accession>
    <name>A0A2M9K2X4_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Shikimate dehydrogenase (NADP(+))</fullName>
            <shortName evidence="3">SDH</shortName>
            <ecNumber evidence="3">1.1.1.25</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">aroE</name>
        <name evidence="6" type="ORF">CG723_02015</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CB01635</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>NADP(+) + shikimate = 3-dehydroshikimate + H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:17737"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16630"/>
            <dbReference type="ChEBI" id="CHEBI:36208"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.25"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 4/7.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the shikimate dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.25" evidence="3"/>
    <dbReference type="EMBL" id="NNBL01000001">
        <property type="protein sequence ID" value="PJN13377.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN13377">
        <property type="protein sequence ID" value="PJN13377"/>
        <property type="gene ID" value="CG723_02015"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00053">
        <property type="reaction ID" value="UER00087"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004764">
        <property type="term" value="F:shikimate 3-dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009073">
        <property type="term" value="P:aromatic amino acid family biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008652">
        <property type="term" value="P:cellular amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009423">
        <property type="term" value="P:chorismate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00222">
        <property type="entry name" value="Shikimate_DH_AroE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046346">
        <property type="entry name" value="Aminiacid_DH-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041121">
        <property type="entry name" value="SDH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013708">
        <property type="entry name" value="Shikimate_DH-bd_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022893">
        <property type="entry name" value="Shikimate_DH_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21089">
        <property type="entry name" value="PTHR21089"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18317">
        <property type="entry name" value="SDH_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08501">
        <property type="entry name" value="Shikimate_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53223">
        <property type="entry name" value="SSF53223"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="2 3" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="3" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Shikimate_dh_N" evidence="4">
        <location>
            <begin position="10"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="domain" description="SDH_C" evidence="5">
        <location>
            <begin position="251"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="region of interest" description="Shikimate binding" evidence="3">
        <location>
            <begin position="18"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="3">
        <location>
            <position position="74"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="70"/>
        </location>
        <ligand>
            <name>shikimate</name>
            <dbReference type="ChEBI" id="CHEBI:36208"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="95"/>
        </location>
        <ligand>
            <name>shikimate</name>
            <dbReference type="ChEBI" id="CHEBI:36208"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="110"/>
        </location>
        <ligand>
            <name>shikimate</name>
            <dbReference type="ChEBI" id="CHEBI:36208"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="134"/>
            <end position="138"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="228"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="230"/>
        </location>
        <ligand>
            <name>shikimate</name>
            <dbReference type="ChEBI" id="CHEBI:36208"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="251"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="258"/>
        </location>
        <ligand>
            <name>shikimate</name>
            <dbReference type="ChEBI" id="CHEBI:36208"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF18317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PJN13377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="291" mass="30190" checksum="C5CE12F2B82EF647" modified="2018-04-25" version="1">MSQDSCLVGLIGSGIGPSLSPALHEREADRQGLRHLYRLIDIDALGVAPDRVGDLVRAARAVGYDGLNITHPCKQLVIEHLDELAPQAEALGAVNTVVFEGGRAVGHNTDVTGFAASFARGLPDAPLDRVVQLGAGGAGAAVAHAVLTLGGGHLTVVDALPERAADLAASLNRHFGEGRASAGTPDRIEEPLARADGLVHATPTGMAAHPGLPLPAHLLRPSLWVAEVVYRPLETELLHTARDLGCATLDGAGMAVFQAADAFRLFTRREPDVTRMLADIAELAGAATARG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K320</accession>
    <name>A0A2M9K320_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Lactamase_B domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_02900</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000001">
        <property type="protein sequence ID" value="PJN13526.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN13526">
        <property type="protein sequence ID" value="PJN13526"/>
        <property type="gene ID" value="CG723_02900"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12706">
        <property type="entry name" value="Lactamase_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lactamase_B" evidence="2">
        <location>
            <begin position="112"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN13526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="346" mass="38329" checksum="BF7926070CB293E3" modified="2018-04-25" version="1">MGESSMTQQSESTAQRADAPASFLPPAEPKPLGGGRMWPKSFADRLTAPLPGLRAFARFAREGALRPPPDALHEIAALPFEPGPLPTVDARTVAVSWAGHASWVLRIGGLTVLTDPVWSRKILGTPARVTPPGIAWSALSPVDAVVISHNHYDHLDAPTLKRLPRDTPVFVPAGLGRWFTRRRFTRVTELDWWEAAELDGVRFDFVPAHHWSKRSLIDTCRTLWGGWVLTDLEGQRVYFAGDTGYGHWFSEIGSRYPGIDLALLPIGAYEPRWWLKDVHCDPEDAVQAAQDVGARRMAPMHWATFLLSAEPVLEPLTRVRAAWQKAGLARKDLWDLPVGASRVLTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K334</accession>
    <name>A0A2M9K334_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_02940</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000001">
        <property type="protein sequence ID" value="PJN13532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN13532">
        <property type="protein sequence ID" value="PJN13532"/>
        <property type="gene ID" value="CG723_02940"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041413">
        <property type="entry name" value="MLTR_LBD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17765">
        <property type="entry name" value="MLTR_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="16"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN13532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="271" mass="29963" checksum="679D74FBC739A0C0" modified="2018-04-25" version="1">MSTATRARQSGIGPLLREWRERRRVSQLELALRADSSARHLSFVETGRSRPSEELVLRLAEHLDVPVRERNALLLAAGYAPRFAETSLDDPSMGALREGLDRLLHGYEPYPALVVDATYTVVAANRGIGMLMEGIPESLLAPPLNAMRLTLHPEGLAPRIRNLREWRGHLLAQMERQIALDRSEALRAVYDEVKAYPVADRDAGDDDGEGGEAVPYFALPMVIEHDGQVLSFVSSISTFNTPMDVTVAELAIETFLPADPATAKYLRSLEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K350</accession>
    <name>A0A2M9K350_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">3-oxoacyl-[acyl-carrier-protein] synthase 3</fullName>
            <ecNumber evidence="8">2.3.1.180</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">3-oxoacyl-[acyl-carrier-protein] synthase III</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Beta-ketoacyl-ACP synthase III</fullName>
            <shortName evidence="8">KAS III</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">fabH</name>
        <name evidence="11" type="ORF">CG723_03070</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CB01635</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched-chain and/or straight-chain of fatty acids.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>acetyl-CoA + H(+) + malonyl-[ACP] = 3-oxobutanoyl-[ACP] + CO2 + CoA</text>
            <dbReference type="Rhea" id="RHEA:12080"/>
            <dbReference type="Rhea" id="RHEA-COMP:9623"/>
            <dbReference type="Rhea" id="RHEA-COMP:9625"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:78449"/>
            <dbReference type="ChEBI" id="CHEBI:78450"/>
            <dbReference type="EC" id="2.3.1.180"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="8">Lipid metabolism; fatty acid biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="8">The last Arg residue of the ACP-binding site is essential for the weak association between ACP/AcpP and FabH.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the thiolase-like superfamily. FabH family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.180" evidence="8"/>
    <dbReference type="EMBL" id="NNBL01000001">
        <property type="protein sequence ID" value="PJN13556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN13556">
        <property type="protein sequence ID" value="PJN13556"/>
        <property type="gene ID" value="CG723_03070"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00094"/>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004315">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033818">
        <property type="term" value="F:beta-ketoacyl-acyl-carrier-protein synthase III activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01815">
        <property type="entry name" value="FabH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013751">
        <property type="entry name" value="ACP_syn_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013747">
        <property type="entry name" value="ACP_syn_III_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004655">
        <property type="entry name" value="FabH_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08545">
        <property type="entry name" value="ACP_syn_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08541">
        <property type="entry name" value="ACP_syn_III_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00747">
        <property type="entry name" value="fabH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="2 8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 8" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="5 8" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="3 8" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="6 8" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="ACP_syn_III" evidence="10">
        <location>
            <begin position="107"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="domain" description="ACP_syn_III_C" evidence="9">
        <location>
            <begin position="225"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="region of interest" description="ACP-binding" evidence="8">
        <location>
            <begin position="242"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="113"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="241"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF08541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF08545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PJN13556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="315" mass="32496" checksum="32D9A01A06F80240" modified="2018-04-25" version="1">MTGSRIAAIGHYQPARLLTNDDLAAMVDTDDAWIRSRVGIRTRHIAGPDEPVDDLAAHAAAKALASAGLTAADIDLVVVATSTAVDRSPNMAARVAHRLGVPSPAALDVNVVCAGFTHALATADHAVRAGAATRALVIGADKMSAVTDWTDRTTCVLVGDGAGAVVVEACPPGDEPGIGPVLWGSVPEMGNAVRIEGEPARFAQEGQSVYRWATQQLPPLARAACERAGYTPADLAAVVLHQANLRIIEPLAEKIGAVNAVVARDVVDSGNTSAASVPLAFSKLVERGEIRTGQPVLLFGFGGNLSYAGQVVRCP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K3G9</accession>
    <name>A0A2M9K3G9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">HDED protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_03685</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000001">
        <property type="protein sequence ID" value="PJN13659.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN13659">
        <property type="protein sequence ID" value="PJN13659"/>
        <property type="gene ID" value="CG723_03685"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005325">
        <property type="entry name" value="DUF308_memb"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03729">
        <property type="entry name" value="DUF308"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="29"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="58"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="84"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="115"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="142"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="167"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN13659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="210" mass="21955" checksum="B1045150C472FBE7" modified="2018-04-25" version="1">MARSHHRDARSHQEGADPATGSKKLRRGFGWIAGLGGVLVIAGLVGLVYTGVATLTSMLLFGWLLLIGGVVGLLHAIQSRGTNFFWLGVVVAALNLAAGVVVIHHPEGTAEALTMFAALLFLTGGVFRLVGGLVVRGPQFGWTLVQGAFGILLGVLVLGNWPSSSRYVIGCFFSLALLFDGLGLLATGLGGRRVVGLMTADDESKHVQPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K3J6</accession>
    <name>A0A2M9K3J6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Carboxypeptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_03635</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000001">
        <property type="protein sequence ID" value="PJN13650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN13650">
        <property type="protein sequence ID" value="PJN13650"/>
        <property type="gene ID" value="CG723_03635"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004181">
        <property type="term" value="F:metallocarboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000834">
        <property type="entry name" value="Peptidase_M14"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00246">
        <property type="entry name" value="Peptidase_M14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00631">
        <property type="entry name" value="Zn_pept"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014696126" evidence="1">
        <location>
            <begin position="36"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M14" evidence="2">
        <location>
            <begin position="52"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN13650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="435" mass="47050" checksum="D82619822FB18845" modified="2018-04-25" version="1">MTPRSTTPRIRIRTLALAATAAALAAPLLTAPAQATSAPPRTGFELSDGARWTGQPEEQDFLAAVDKGSDRVSVDTAGTTEQGRPVQLVRIGAHRTANTVLLICSQHGNEPSGREACLTTIRDLAYAKDRRTKAFLSRTTLLVVPTANPDGRAANTRGNSDGIDINRDHIALETAEARAMAAVIRDRKPDVIYDLHEYGATPKYYDKDLFDLWPRNLNTDTQVHDEAETLSTAYVRPAANAGEYSTGTYGIWTDPVTGEPVKQTAGDGQERILRNVSGVKHAVGLLIESRVDPQTDAEKADPALNNRRRVKSQLSALGGLFTFTDQHRGRIEAATGAARVAGYRDRGPVYVGGADNDPAEPAETIQNPPCGYRLDPSQYASVKDKLALHGITVRKNRTGEGAFVPLRQSERALVTLLLDARAPYHLIEGEPDTTC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JEU6</accession>
    <name>A0A2M9JEU6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CG723_44985</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000049">
        <property type="protein sequence ID" value="PJN05420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN05420">
        <property type="protein sequence ID" value="PJN05420"/>
        <property type="gene ID" value="CG723_44985"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PJN05420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="62" mass="6636" checksum="7D566A19BF8C5245" modified="2018-04-25" version="1">MPLQAQQDSPADVSASDDARLADVYGAVRRDRSGRPFVFLADHLPGGKEFEVGAVLPSLHSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JEV4</accession>
    <name>A0A2M9JEV4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">TetR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CG723_45025</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000049">
        <property type="protein sequence ID" value="PJN05426.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN05426">
        <property type="protein sequence ID" value="PJN05426"/>
        <property type="gene ID" value="CG723_45025"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041347">
        <property type="entry name" value="MftR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17754">
        <property type="entry name" value="TetR_C_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="3">
        <location>
            <begin position="21"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="44"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="214"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PJN05426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="238" mass="25821" checksum="F1BDA7F6BDECC019" modified="2018-04-25" version="1">MADDVVSTERSRGGMSEQRRRRVRLEISREAARLFWAQGVDGTSGDQIAEAVGLSTRTIWRHFRSKESCAEPIVAQSVEWELATLRSWPLHRSLEEHFATEAKRLVSEISPSEQADAGLGVKMIRLAETEPALRTAWLMACDQVEHELAAVIATRLGLKPDDLQVRLHAAAAAAALRVINEYVGAGLLDGTDPRKLGDESFAFIADAVRTATGGAVGDPVQVDEAPAAPDEGAADREE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JEZ4</accession>
    <name>A0A2M9JEZ4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_44830</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000048">
        <property type="protein sequence ID" value="PJN05465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN05465">
        <property type="protein sequence ID" value="PJN05465"/>
        <property type="gene ID" value="CG723_44830"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="103"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN05465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="122" mass="12848" checksum="278F0DBA3C1847B5" modified="2018-04-25" version="1">MIVTVPASAGFGKAELQLDIDDAEHERRRAAGLGVAIGHGFGGLDVLMALPHGLPVPVTDLTDHQRAYVRQAPAGICTIDGQNVTRHVTWPCRVTVATVQATSPTKMELDAARSSRRSAPAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-06-02" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JF38</accession>
    <name>A0A2M9JF38_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Mycofactocin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">mftA</name>
        <name evidence="1" type="ORF">CG723_44430</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000047">
        <property type="protein sequence ID" value="PJN05494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN05494">
        <property type="protein sequence ID" value="PJN05494"/>
        <property type="gene ID" value="CG723_44430"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023988">
        <property type="entry name" value="MftA"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03969">
        <property type="entry name" value="mycofactocin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PJN05494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="40" mass="4321" checksum="CDC200A936E9952D" modified="2018-04-25" version="1">MNEFDTVPADEQVTEVAADTLVETDALIEEVSIDGMCGVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JFF5</accession>
    <name>A0A2M9JFF5_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Reductase_C domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_44390</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000047">
        <property type="protein sequence ID" value="PJN05487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN05487">
        <property type="protein sequence ID" value="PJN05487"/>
        <property type="gene ID" value="CG723_44390"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.30">
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016156">
        <property type="entry name" value="FAD/NAD-linked_Rdtase_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028202">
        <property type="entry name" value="Reductase_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14759">
        <property type="entry name" value="Reductase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55424">
        <property type="entry name" value="SSF55424"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reductase_C" evidence="1">
        <location>
            <begin position="55"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN05487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="132" mass="14491" checksum="F4BB397A12E53488" modified="2018-04-25" version="1">MYAAGDVARWPHPQFGFLVRFEHGTNAADQARCAVARLDTCVPYRPSDYVWPGCDWRLQIVGRLQADGTEALFGNLELERPRAALPHADAAGRLCAAVVLNWPESFLQCRRMIAAGAEIVEARNLLNAAGQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JFH4</accession>
    <name>A0A2M9JFH4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MerR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_30945</name>
        <name evidence="2" type="ORF">CG723_43885</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="E11131" last="E11140">
            <title>Discovery of the leinamycin family of natural products by mining actinobacterial genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
            <dbReference type="PubMed" id="29229819"/>
            <dbReference type="DOI" id="10.1073/pnas.1716245115"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000045">
        <property type="protein sequence ID" value="PJN05553.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="NNBL01000017">
        <property type="protein sequence ID" value="PJN07828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN05553">
        <property type="protein sequence ID" value="PJN05553"/>
        <property type="gene ID" value="CG723_43885"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN07828">
        <property type="protein sequence ID" value="PJN07828"/>
        <property type="gene ID" value="CG723_30945"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000551">
        <property type="entry name" value="MerR-type_HTH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13411">
        <property type="entry name" value="MerR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00040">
        <property type="entry name" value="HTHMERR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00422">
        <property type="entry name" value="HTH_MERR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="SSF46955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50937">
        <property type="entry name" value="HTH_MERR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH merR-type" evidence="1">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN05553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN07828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="121" mass="13242" checksum="FAA849C4883FB8C7" modified="2018-04-25" version="1">MRIGELAAQTGMTRDTIRFYEKIGLIAGRRLTNGYRDFPPEAVAWLHYVRTAQTLGFSLAEIARTGEELHGAPDVAEALSALFEEKIQLVDARMAELATLRAELTERVGTGCPLRAAGRPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JFM2</accession>
    <name>A0A2M9JFM2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CG723_43540</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CB01635</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000043">
        <property type="protein sequence ID" value="PJN05684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN05684">
        <property type="protein sequence ID" value="PJN05684"/>
        <property type="gene ID" value="CG723_43540"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="90"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="114"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="148"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="174"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="210"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="234"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="278"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="317"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="343"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="370"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="469"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="23"/>
            <end position="492"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PJN05684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="502" mass="50689" checksum="B76B827AAAB22960" modified="2018-04-25" version="1">MTATTAENSTAATGGGHPQRWLILGVICLAQLTVLLDNTVLNVAIPSLTRELDASTSDIQWMINAYSLVQSGLLLTAGSSADRYGRKKMLAAGLVLFGAGSLVAGLAQSTGQLIAARAGMGIGGALLMTTTLAVVVQIFDDKERVRAIGLWATVNSLGFAAGPLIGGVMLDHFWWGAIFLINIPVAVIGLIAVIALVPESKNPLGDRPDLVGALLSTVGMTGVVYAIISGPQHGWTSAHVGISALVGLVVLGAFVVWELRIPYPMLDMHFFRNQQFTGAVAGAILVAFGMGGSLFLLTQHLQFVLGYGALEAGLRTAPMALTVVVLNLTGVGARILPKLGTPATIATGMSCLAAGLAAIALLGGDSYGGMLLGLVVMGAGISIAMPAMANAIMSAIPPEKAGVGAGVNGTLAEFGNGLGVAVLGAVLNSRFAALVSVSAASLPAALAAAKSGAERERIADAFSSGLETSQLVGAVAVLVGGLLAAALLRRAERADSAVKAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JFP9</accession>
    <name>A0A2M9JFP9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alpha/beta hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_43080</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000042">
        <property type="protein sequence ID" value="PJN05716.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN05716">
        <property type="protein sequence ID" value="PJN05716"/>
        <property type="gene ID" value="CG723_43080"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00111">
        <property type="entry name" value="ABHYDROLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="16"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN05716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="259" mass="27017" checksum="460040309D920C17" modified="2018-04-25" version="1">MSTVHVEEAGDHGPLLLCLHGIGSSSAAFAPQLAELSAYARVVAWDAPGYAKSPDPEGPLDLDGFADAAAEVIRERGGRAHVLGVSWGGVIALRLAARHPDLVESLVVADSSAGSGTDPAKAEGMRARAAELAELGPRAFAEKRGPRLVSGGAPEELVQRVVDTMASSVRLPGYAYAAESMASADLRPELPEIAAPTLVLCGDQDRVTGVEASQVLAGALHKTAYVIVKDAGHLANQEQPARFDAWVLSHLRITARIPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JFT2</accession>
    <name>A0A2M9JFT2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Chaplin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CG723_43200</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000042">
        <property type="protein sequence ID" value="PJN05739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN05739">
        <property type="protein sequence ID" value="PJN05739"/>
        <property type="gene ID" value="CG723_43200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007155">
        <property type="term" value="P:cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005528">
        <property type="entry name" value="ChpA-H"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03777">
        <property type="entry name" value="ChpA-C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51884">
        <property type="entry name" value="CHAPLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0034">Amyloid</keyword>
    <keyword evidence="2" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014650724" evidence="5">
        <location>
            <begin position="26"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="domain" description="Chaplin" evidence="6">
        <location>
            <begin position="36"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PJN05739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="77" mass="7217" checksum="C4F3930FD406B116" modified="2018-04-25" version="1">MIKKVVAAAAATGGLVLAGAGIAAADAGAQGAAVKSPGVISGNVIQVPVHIPVNACGNTVSVIGLLNPAFGNACVNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JFU7</accession>
    <name>A0A2M9JFU7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">ROK family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CG723_43245</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000042">
        <property type="protein sequence ID" value="PJN05751.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN05751">
        <property type="protein sequence ID" value="PJN05751"/>
        <property type="gene ID" value="CG723_43245"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000600">
        <property type="entry name" value="ROK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18964">
        <property type="entry name" value="PTHR18964"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00480">
        <property type="entry name" value="ROK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PJN05751.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="286" mass="29157" checksum="BDA0998836BB1B70" modified="2018-04-25" version="1">MPPSTPVVLALDFGGTKTALTVADQHGTRLHDLTVETAPEHGAQAGLKRAVGAARSLLDGREPVAVGVSTIGIPGADGVALAPNIPGWEELALGRELALEFPDSELRLATDVKAAARYECDAGALKGCDPGLYVNLGTGLAVAIVAGGTVLTGRHGASGEIGYNLRAAADVGLASGDRIPLEDVVSGKALSQAAQAQGSTELAGHIGEFIDELAFHLVNLAIAVDPERIVVGGGMVRSWEALHDRLRHALDAAVPYPPQLVPAAHPYDAPLLGALALAVEAARTGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JFV1</accession>
    <name>A0A2M9JFV1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_43845</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000044">
        <property type="protein sequence ID" value="PJN05627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN05627">
        <property type="protein sequence ID" value="PJN05627"/>
        <property type="gene ID" value="CG723_43845"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="103"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN05627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="122" mass="12979" checksum="66384B4086FB5118" modified="2018-04-25" version="1">MPATHQVPRVAGKGISTAQPDARVERGNRTRQAVLSPTVEIVSVEGLQAPPRAELEVPSLVQQLSGHRDLAGLRTRGTDDLQHVRPLRDHLVQVHAITGQIIPGCGGDLPAVPQTGHPAPPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-05-25" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JFY9</accession>
    <name>A0A2M9JFY9_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7">DNA repair protein RecN</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6 7">Recombination protein N</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">recN</name>
        <name evidence="9" type="ORF">CG723_42930</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CB01635</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 7">May be involved in recombinational repair of damaged DNA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the RecN family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000041">
        <property type="protein sequence ID" value="PJN05788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN05788">
        <property type="protein sequence ID" value="PJN05788"/>
        <property type="gene ID" value="CG723_42930"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004604">
        <property type="entry name" value="DNA_recomb/repair_RecN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003395">
        <property type="entry name" value="RecF/RecN/SMC_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11059">
        <property type="entry name" value="PTHR11059"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02463">
        <property type="entry name" value="SMC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF003128">
        <property type="entry name" value="RecN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00634">
        <property type="entry name" value="recN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0227">DNA damage</keyword>
    <keyword evidence="7" id="KW-0234">DNA repair</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SMC_N" evidence="8">
        <location>
            <begin position="12"/>
            <end position="529"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00033408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR003128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02463"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PJN05788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="575" mass="59779" checksum="2262F03B78EA50AD" modified="2018-04-25" version="1">MRIRSLGVIDDAVVELSPGFTAVTGETGAGKTMVVTSLGLLLGGRADPALVRIGAKAAVVEGRITVPEGTAAIVRAQEAGAELDDGALLISRTVSAEGRSRAHLGGRSVPVGMLTELADELVAVHGQTDQQGLLKLSRQRGALDRYAGDAVAVPLTKYQAAYRRLRAVSAELDTIVTRARERAQEADLLRFGLDEIAAVEPRGGEDVELSAEAERLGHAEALASAASAAHAALAGNPEDPEGVDATTLVGGANRALDAVRSHDPALSALADRIGEIGILLSDVAGELAGYADDLDADPLRLAAVEERRAALTQLTRKYGGAGGSTDEVLAWAEQGSARLLELDGDDDRIGELTAERDGLRGELGALAQALTDSRTEAASRFAAAVTQELASLAMPHARVSFDIRRTDDPDGVELDGRTVAYGPSGVDEVELLLAPHPGAPPRPIAKGASGGELSRVMLAVEVVFAGTDPVPTYLFDEVDAGVGGKAAVEIGRRLAKLAKSAQVVVVTHLPQVAAFADRQLLVEKTNDGTVTRSGVTVLEGEDRIRELSRMLAGQEDSETARAHAEELLATARADA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JG91</accession>
    <name>A0A2M9JG91_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF58 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_42190</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000039">
        <property type="protein sequence ID" value="PJN05852.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN05852">
        <property type="protein sequence ID" value="PJN05852"/>
        <property type="gene ID" value="CG723_42190"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002881">
        <property type="entry name" value="DUF58"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01882">
        <property type="entry name" value="DUF58"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF58" evidence="1">
        <location>
            <begin position="192"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN05852.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="436" mass="47142" checksum="D3EF486406FA52AE" modified="2018-04-25" version="1">MALTGRTALLAALGSLPVGIWEPSWTGILAVNTPLALACACDFALAAPVRRLRLTRSGDTAVRLGDPADVTLTVTNPSRRPLRAQLRDAWPPSSWLPGTEVEASRHRVTIPPGERRRITTRLLPTRRGDRKADRVTIRSYGPLGLFTRQGSHDVPWTVRVLPPFHSRKHLPSKLARLRELDGRTSVLTRGEGTEFDSLRAYVPGDDTRSIDWRATARQSTLAVRTWRPERDRHILLVLDTGRTSAGRVGDSPRLDASMDAALLLGALASRAGDRVDLLAYDRRIRALVQGRAAGELLPALVNAMAPLEPELVETDARGLTAAVLHTAPRRSLVVLLTSLDAAPVEEGLLPVLSRLTKRHTVLVASVADPTIAEMAGSRGNTEAVYDAAAAAQAQAERRRTAELLIRRGVTVVDATPNDLAPALADAYLALKAAGRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JG95</accession>
    <name>A0A2M9JG95_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Phosphopantetheine--protein transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_42005</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000038">
        <property type="protein sequence ID" value="PJN05911.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN05911">
        <property type="protein sequence ID" value="PJN05911"/>
        <property type="gene ID" value="CG723_42005"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025669">
        <property type="entry name" value="AAA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13614">
        <property type="entry name" value="AAA_31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="AAA_31" evidence="1">
        <location>
            <begin position="174"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN05911.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="413" mass="44960" checksum="19BEEFE39014C174" modified="2018-04-25" version="1">MSSPTTSGDREKVVSKLPGLLRQSLKVRCAQHGLEIQTAIEQAVRAWTGLASGLEPVDTAGADSFSTFLPHGQWDDFKAVTKQRSVSLTQGLAQAVHMWLDSHPAPEIERPVVTRRFVVCNQKGGVGKTAITAGLGEAMAEDRNSLYPVQIAKQLASEPDGDEDPLGVENLPGIGLRVLLVDFDPQCHLTNQLGATPLPISQDGDSLTNHMGGSPKGDLRDLIVTVDGERFGDRLHLLPSCNDAFLLDVRLSGVRAREAALERALAPLEADYDVIVVDCPPSLGLSMDAAVYYGRRRKDEVPGQSGPLVVVQAEDSSADAYDLLTNQIEDLRNDMDLDVDYLGLVVNLYDPRRGYIATSSLEGWMDIKDPRVVAIVSERKEQKEAVRMKQPLLSYAPKSQIAISMRAMARELS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JGW1</accession>
    <name>A0A2M9JGW1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_40975</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000035">
        <property type="protein sequence ID" value="PJN06118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN06118">
        <property type="protein sequence ID" value="PJN06118"/>
        <property type="gene ID" value="CG723_40975"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="40"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN06118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="62" mass="6042" checksum="8BC0D226C4A82344" modified="2018-04-25" version="1">MTNQNPQPLLGLRTALVLLLGCLVALGAGVLTMLAGGHVASAALAGGAAFGAGVLFFHTIIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JHA2</accession>
    <name>A0A2M9JHA2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Alkaline phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CG723_40140</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000033">
        <property type="protein sequence ID" value="PJN06232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN06232">
        <property type="protein sequence ID" value="PJN06232"/>
        <property type="gene ID" value="CG723_40140"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014036">
        <property type="entry name" value="DeoR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001034">
        <property type="entry name" value="DeoR_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018356">
        <property type="entry name" value="Tscrpt_reg_HTH_DeoR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00455">
        <property type="entry name" value="DeoRC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08220">
        <property type="entry name" value="HTH_DeoR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00037">
        <property type="entry name" value="HTHLACR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00420">
        <property type="entry name" value="HTH_DEOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="SSF100950"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00894">
        <property type="entry name" value="HTH_DEOR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51000">
        <property type="entry name" value="HTH_DEOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH deoR-type" evidence="4">
        <location>
            <begin position="3"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PJN06232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="259" mass="27364" checksum="86F9D90CAB340789" modified="2018-04-25" version="1">MSRDARWKSLLELLVERGRLDVEEAAADLGVSAATIRRDFDQLAEQQMLVRTRGGAVVHGVSYELPLRYKTARNASEKERIAKAVAELITPGEAVGLTGGTTTTEVARALAVRPDLASGSPALTIVTNALNIANELAVRPQFKIVVTGGVARPQSYELIGPLADGVLSQITIDTAVLGVVGFDVAHGAAAHDEAEAAINRLLCERAERVIVAADSSKLGQRAFARICSTERIGTLVTDSAVDAATVERFEEAGVKVLAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-06-02" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JHN4</accession>
    <name>A0A2M9JHN4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_39765</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000031">
        <property type="protein sequence ID" value="PJN06396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN06396">
        <property type="protein sequence ID" value="PJN06396"/>
        <property type="gene ID" value="CG723_39765"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="113"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="168"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="205"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN06396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="325" mass="33117" checksum="FCDB9EC87B747EB3" modified="2018-04-25" version="1">MAGTDDAVAAGDDALYVLTAVLLTPAKFPSVLGDDYPEACAALGLAPLADGYGLVLGQDGAGARWTVVIDDVSLVAVAIASWDCGMEYELSPDDRTVVSALPGWPLALSVSAPGVPAPHDPEHDPEIMDGPPLTPPNTETWGPAQRRLGADEIALQWASWRDQIDDSAFLADGPGGADVTGGTQDSEGAAGAEAPEGAGGTGSDRPDAGSTSTPDSGDATAASPAASDPEAQSTRAPHAGIRRVLAEVRAYVDSPPPLGRVRSAFASGEARTLRADGPGWSMVARTDDIAFVLLDDEPGEVLPVGRGPELPGLLEALDKMAVRPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JHP3</accession>
    <name>A0A2M9JHP3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Dynein regulation protein LC7</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_39730</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000031">
        <property type="protein sequence ID" value="PJN06390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN06390">
        <property type="protein sequence ID" value="PJN06390"/>
        <property type="gene ID" value="CG723_39730"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004942">
        <property type="entry name" value="Roadblock/LAMTOR2_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03259">
        <property type="entry name" value="Robl_LC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00960">
        <property type="entry name" value="Robl_LC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Robl_LC7" evidence="1">
        <location>
            <begin position="17"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN06390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="145" mass="15082" checksum="60A66100A8840D15" modified="2018-04-25" version="1">MIQDPTMDAAPRSGELDWLLDDLVQRVAELRHAVVLSNDGLAVGASSALGREDAEHLAAVASGFHSLAKGAGRHFGAGGVRQTMVEMDDGFLFVAAAGDGSCLAVLSTADADIGLVAYEMARMVKRVGEHLYTPPRFAAHPPAAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JHV2</accession>
    <name>A0A2M9JHV2_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">UBP-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_39355</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000030">
        <property type="protein sequence ID" value="PJN06454.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030082447.1">
        <property type="nucleotide sequence ID" value="NZ_NNBL01000030.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN06454">
        <property type="protein sequence ID" value="PJN06454"/>
        <property type="gene ID" value="CG723_39355"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001607">
        <property type="entry name" value="Znf_UBP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02148">
        <property type="entry name" value="zf-UBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50271">
        <property type="entry name" value="ZF_UBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UBP-type" evidence="1">
        <location>
            <begin position="21"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN06454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="87" mass="9776" checksum="7EBC1D7B5C5F47A5" modified="2018-04-25" version="1">MTTESDWHLSLVRPVTPRTPEGCEECLRLGSPWVHLRLCLTCGHVGCCDSSPLKHARLHAANVGHPIVQPLEPGENWRWCYVHEAVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JID1</accession>
    <name>A0A2M9JID1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GNAT family N-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_37780</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000027">
        <property type="protein sequence ID" value="PJN06639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN06639">
        <property type="protein sequence ID" value="PJN06639"/>
        <property type="gene ID" value="CG723_37780"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="3"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="174"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN06639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="306" mass="33170" checksum="18DB9FDE6A4B541C" modified="2018-04-25" version="1">MTVIVRALRPEDAAAFARVRRAALPAMLATAESVAFDLAHAHPDARYRPLVAEAEGEVVGTAQVGIAYDSPDPGQGYVNAYVHPERRGLGAGSLIVRAAEEYLAGEGAVAVYSWVLDTPDDRAFATRRGYHASRPAHFLRLDLAHGTLPPLTAPPAGVTLRTGADFADGPRPLFDLDAETVSDEPSDVATEFTDYEHWLDETWHHPLTDHRLTSVAVVCGRPVAFSLARTDDETRYMSGMTGTAREFRGHGLAKLAKNDSLHRAREAGITEAFTGNDAGNGPMLAINKWFGYEICATEVRHVRTLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JII2</accession>
    <name>A0A2M9JII2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CG723_38140</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CB01635</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000027">
        <property type="protein sequence ID" value="PJN06696.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN06696">
        <property type="protein sequence ID" value="PJN06696"/>
        <property type="gene ID" value="CG723_38140"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="35"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="94"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="127"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="176"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="234"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="277"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="90"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PJN06696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="312" mass="33400" checksum="58B5AFCA933D5FCF" modified="2018-04-25" version="1">MTTMTSTAGETAVRRPTSSPPDTARRTRRQGGTILALPALVWYLVFMVGPLVAIFVVAALHWPGMLQPVSFAGFDNVRTVFADPVFWDAVSNTAIQLVVAVPVMVVCAYMLGYYVAQKPPGHKVVRYLLFIPGLISTPAKAMVFYAALSPDGLVNGGLKAVGLGSLADAWLASPSTALACLIALDIWAGIGFTAVLFAARLGSVPDELGEAAQLDGAGHWRTMWRIHFPVIKDYVGVVTMLQFLWTLFGSAQHVLLLTQGGPGSSSTTLSFLVYQKAFIAADLGYSQTVGVFLFLAGLVGLLAIRRAFRQNH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JJ07</accession>
    <name>A0A2M9JJ07_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CG723_36915</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000025">
        <property type="protein sequence ID" value="PJN06864.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN06864">
        <property type="protein sequence ID" value="PJN06864"/>
        <property type="gene ID" value="CG723_36915"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PJN06864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="132" mass="14115" checksum="7F899FCEA5BAD790" modified="2018-04-25" version="1">MPGIDECLLEAMRLPGARGASVVDWTSGLALGTVGDSPNGDHEATAAEAAELARMTAEHRAFAPAGGADWSAGEPPVEDVIVTSRDGYHVLRFVRTTFDSSVFLHLWLDREQGNLALSRIRLGEMADRLVLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JJ27</accession>
    <name>A0A2M9JJ27_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 4">N5-carboxyaminoimidazole ribonucleotide mutase</fullName>
            <shortName evidence="3 4">N5-CAIR mutase</shortName>
            <ecNumber evidence="3 4">5.4.99.18</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">5-(carboxyamino)imidazole ribonucleotide mutase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3 7" type="primary">purE</name>
        <name evidence="7" type="ORF">CG723_37005</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CB01635</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3 4">Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3 4">
            <text>5-carboxyamino-1-(5-phospho-D-ribosyl)imidazole + H(+) = 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate</text>
            <dbReference type="Rhea" id="RHEA:13193"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58730"/>
            <dbReference type="ChEBI" id="CHEBI:77657"/>
            <dbReference type="EC" id="5.4.99.18"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 4">Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate from 5-amino-1-(5-phospho-D-ribosyl)imidazole (N5-CAIR route): step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the AIR carboxylase family. Class I subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.4.99.18" evidence="3 4"/>
    <dbReference type="EMBL" id="NNBL01000025">
        <property type="protein sequence ID" value="PJN06879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN06879">
        <property type="protein sequence ID" value="PJN06879"/>
        <property type="gene ID" value="CG723_37005"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00943"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034023">
        <property type="term" value="F:5-(carboxyamino)imidazole ribonucleotide mutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01929">
        <property type="entry name" value="PurE_classI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033747">
        <property type="entry name" value="PurE_ClassI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000031">
        <property type="entry name" value="PurE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024694">
        <property type="entry name" value="PurE_prokaryotes"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00731">
        <property type="entry name" value="AIRC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001338">
        <property type="entry name" value="AIR_carboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01001">
        <property type="entry name" value="AIRC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01162">
        <property type="entry name" value="purE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 4" id="KW-0413">Isomerase</keyword>
    <keyword evidence="1 3 4" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AIRC" evidence="6">
        <location>
            <begin position="5"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3 5">
        <location>
            <position position="13"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3 5">
        <location>
            <position position="16"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3 5">
        <location>
            <position position="43"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR001338"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR001338-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM01001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PJN06879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="175" mass="18324" checksum="5E7BA6E3032BC580" modified="2018-04-25" version="1">MSTSPVVGIVMGSDSDWPVMEAAAQVLDEFEIPYEVDVVSAHRMPREMIAYGEQADGRGLKAIIAGAGGAAHLPGMLASVTPLPVIGVPVPLKYLDGMDSLLSIVQMPAGVPVATVSVGGARNAGLLAARILATHDEDLLGRMREFQQELNDQATEKGKRLRAKVEGASGFGFGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JJE6</accession>
    <name>A0A2M9JJE6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Dipeptide/oligopeptide/nickel ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CG723_36410</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000024">
        <property type="protein sequence ID" value="PJN06972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN06972">
        <property type="protein sequence ID" value="PJN06972"/>
        <property type="gene ID" value="CG723_36410"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015833">
        <property type="term" value="P:peptide transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013563">
        <property type="entry name" value="Oligopep_ABC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08352">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01727">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="7"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="53"/>
            <end position="60"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PJN06972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="339" mass="36877" checksum="59DE41AA8AD437D2" modified="2018-04-25" version="1">MTDDVILRAEGLVKHYGGGPALPWRRGRGAAVVRAVDGVDLELRRGQALGIVGESGCGKSTLLRLLCALERPTDGRLLFEGEDVARLRGAALKRWRRRVQVVFQDPYASLNPRLRVGEIIGEAFDVHPDVVPRAGRRARIAELLELVGLDARHADRYPHQFSGGQRQRIGIARGLALGPDVLLCDEPVSALDLSVQAQVVNLLLKLRRELGLALVFVSHDLGVVRHVCDDVTVMYLGKVAEQAPVDALYAAPGHPYTEALLSAEPSLDRIRDPHAPHRTRIVLAGDPPSPSAPPPGCRFHTRCPRAQDLCRDTEPLLTVRGQRAGACHFTDAMLAGSVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JJR3</accession>
    <name>A0A2M9JJR3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CG723_36200</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000024">
        <property type="protein sequence ID" value="PJN07017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN07017">
        <property type="protein sequence ID" value="PJN07017"/>
        <property type="gene ID" value="CG723_36200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PJN07017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="143" mass="15519" checksum="34976D93A42BB33E" modified="2018-04-25" version="1">MTSPEPHECPLHGAGVDPDRLAGRRVKQVVAAWHRHDCEDAAGPLEIWLVDDVGDYIHITAGSDWCLIVDETAPHVGYDLGESGRVEVVASERGTPFARYAGEVVLAVDQRFDVRTGRVGLEICFSTGSVQCGSWRGDLHLVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JJT3</accession>
    <name>A0A2M9JJT3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DEAD/DEAH box helicase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CG723_35400</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000023">
        <property type="protein sequence ID" value="PJN07136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN07136">
        <property type="protein sequence ID" value="PJN07136"/>
        <property type="gene ID" value="CG723_35400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022307">
        <property type="entry name" value="Helicase_put_actinobac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018973">
        <property type="entry name" value="MZB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09369">
        <property type="entry name" value="DUF1998"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03817">
        <property type="entry name" value="DECH_helic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0347">Helicase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="2">
        <location>
            <begin position="99"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="3">
        <location>
            <begin position="322"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="806"/>
            <end position="840"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="812"/>
            <end position="830"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PJN07136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="840" mass="90119" checksum="4658A38AFA4F6D3D" modified="2018-04-25" version="1">MHDALGALSVTPVTHSVPMAKNHRPGQPAADTASRPSPGAILDRLASGPSRASRITHTEHLPPRPGRHAVWPDRIRSEVLAAVQSAGIEHPWAHQALAAEHAMDGESVVVSTGTASGKSLAYLVPVLSRLLDGSEAPNGRGATALYLAPTKALAADQCRSVKELSQPLGTAIRPAVYDGDTPVEEREWVRQYANYVLTNPDMLHRGILPSHPRWSSFLKSLKYVVIDECHTYRGIFGSHVAQVLRRLRRLCARYGSEPVFLLASATAADPAVAAERLTGLPVVEIADDASPRGELVFALWEPPLTELHGEKGAPVRRTATAETADLLTDLTLQGVHSVAFVRSRRGAELISVIAQERLAEIDRSLARRVAAYRGGYLPEERRALERALHSGELLGLAATTALELGIDVSGLDAVVIAGYPGTRASLWQQAGRAGRSGQGALAVLVARDDPLDTYLVHHPEALFDQPVESTVLDPDNPYVLAPHLCAAAAELPLTDDDLPLFGPTTAELLPQLEDAKLLRRRTKAWHWTRRERAADLTDIRGDGGSPVQIVEAGTGRLLGTVDAGSAHTTVHDGAVHLHQGRTYLVKHLDLEDSVALVEEANPTYSTTARDTTAISVLERDIEVPWGDGRLCYGSVEVTNQVVSFLRRRLITGEVLGETKLDLPPRTLRTRAVWWTVTEDQLDAARVNPEILGGALHAAEHASIGMLPLFATCDRWDIGGVSIPLHPDTLLPTVFVYDGHPGGAGFAERAFHTAREWLTATLEAISSCECEAGCPSCIQSPKCGNGNDPLHKRGAVRLLKILLRDAPSAGAPTPASASASLEAASEGRPTSQDQEPGRDAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JJZ6</accession>
    <name>A0A2M9JJZ6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">GntR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_34970</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">In the C-terminal section; belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000022">
        <property type="protein sequence ID" value="PJN07195.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN07195">
        <property type="protein sequence ID" value="PJN07195"/>
        <property type="gene ID" value="CG723_34970"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07377">
        <property type="entry name" value="WHTH_GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
        <property type="entry name" value="GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00035">
        <property type="entry name" value="HTHGNTR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00345">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50949">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH gntR-type" evidence="2">
        <location>
            <begin position="34"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN07195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="487" mass="51266" checksum="8606CB1482C1641F" modified="2018-04-25" version="1">MTSSGTNPRAADGGGQASSAAWELLLPAVSAPARARGRGLQAALRDAVRSGRLAPGTRMPSSRDLAADLGVSRGLITEAYEQLTAEGYLRSGRGAGTWVGGAVRAAAAAGVRDLAPRPPGTRADFVAGSPDLSLFPRAAWAAAQRGVLAELPHHMLGYPDPRGIPRLRTALAELLARRRGVVADPERIIVCSGVAQAVTLLGFVLHARGERSVGVEDPGSPDLGSLFASAGVGTTPLPLDGEGPAIGPLRDAGVRSVVTTPSHQFPSGIAYSPARRTQLLDWARSVDGLVIEDDYDGDFRYDRAPVGALQGLDPEHVAYTGSVSKSLAPGLRLGWMVVPAGLTDEVVERKRYMDLGNPALDQALLARFIERGDYDRQLRRCQRAYRERRDTLVAALHEHLPGTQVTGIAAGLHVIACLPERYGSQEALLERASAAGVTVRALSHYGTSDSGDGGVRLVLGYAHLPPARIAEGVRLLARAAHERAARA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JK15</accession>
    <name>A0A2M9JK15_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">YigZ family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CG723_35020</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CB01635</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the IMPACT family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000022">
        <property type="protein sequence ID" value="PJN07204.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN07204">
        <property type="protein sequence ID" value="PJN07204"/>
        <property type="gene ID" value="CG723_35020"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035647">
        <property type="entry name" value="EFG_III/V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023582">
        <property type="entry name" value="Impact"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015796">
        <property type="entry name" value="Impact_bac/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001498">
        <property type="entry name" value="Impact_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036956">
        <property type="entry name" value="Impact_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015269">
        <property type="entry name" value="UPF0029_Impact_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020569">
        <property type="entry name" value="UPF0029_Impact_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16301">
        <property type="entry name" value="PTHR16301"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09186">
        <property type="entry name" value="DUF1949"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01205">
        <property type="entry name" value="UPF0029"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54980">
        <property type="entry name" value="SSF54980"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00257">
        <property type="entry name" value="IMPACT_YIGZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00910">
        <property type="entry name" value="UPF0029"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UPF0029" evidence="2">
        <location>
            <begin position="20"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="domain" description="DUF1949" evidence="3">
        <location>
            <begin position="140"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF09186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PJN07204.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="208" mass="22583" checksum="06B9B7B65FFC06B4" modified="2018-04-25" version="1">MQDEYRTVAREGVHETEINRSRFLCALAPAATEREAQDFVARIRKEHPTASHNCYAYVIGADASVQKASDDGEPGGTAGVPMLQMLTRREMRYVVAVVTRYYGGVKLGAGGLIRAYGGAVGEALDALGTLTRRRFRLATVTVDHQRAGKVQNDLRSTGREVRDVRYGEAVTIEIGLPDADVDTFRAWLADVTAGTAEFELGGEAYGDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JKD1</accession>
    <name>A0A2M9JKD1_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Glucanase</fullName>
            <ecNumber evidence="8">3.2.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CG723_34290</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CB01635</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="8">Belongs to the glycosyl hydrolase family 6.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.-" evidence="8"/>
    <dbReference type="EMBL" id="NNBL01000021">
        <property type="protein sequence ID" value="PJN07324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN07324">
        <property type="protein sequence ID" value="PJN07324"/>
        <property type="gene ID" value="CG723_34290"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030245">
        <property type="term" value="P:cellulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016288">
        <property type="entry name" value="Beta_cellobiohydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036434">
        <property type="entry name" value="Beta_cellobiohydrolase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001524">
        <property type="entry name" value="Glyco_hydro_6_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34876">
        <property type="entry name" value="PTHR34876"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01341">
        <property type="entry name" value="Glyco_hydro_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001100">
        <property type="entry name" value="Beta_cellobiohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00733">
        <property type="entry name" value="GLHYDRLASE6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51989">
        <property type="entry name" value="SSF51989"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00656">
        <property type="entry name" value="GLYCOSYL_HYDROL_F6_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="2 8" id="KW-0136">Cellulose degradation</keyword>
    <keyword evidence="4 8" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="1 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 8" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014489612" description="Glucanase" evidence="8">
        <location>
            <begin position="21"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="20"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="48"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="6 7">
        <location>
            <position position="201"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="6">
        <location>
            <position position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR001100-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PJN07324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="372" mass="38416" checksum="6424704A98DE96C9" modified="2018-04-25" version="1">MAAAASVVAAVGVVTGMVSALDGSEGGDVARPRATRSPDLLPLPAVPSATSASASPSPSAGPSRTARKRPKPTPKASDGRSAAPASTRLYRHTDSQVLDWVRTNRSDPRRALIESRIADRPAAVWFAGFTPGTITSRVRAVTSTAAREGRVPVLVPYAIPERDCGGASEGGAPDIAAYDSWTRKFAAGLGSGEVVLILEPDALSQTECLSGGQLADRYAALARAGRAFKSANPRARVYYDAGHSDWNPAGTQAARLRAAGAASPDSSDGIFTNVSNFNRTPAEVAYARRVLAAMGGPPSLGAVIDTSRNGNGAPANGAWCDPSGRKLGQAPTLRTGERGIDAYLWVKLPGESDGCKGEPGSFAPDYAYDLAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JKL3</accession>
    <name>A0A2M9JKL3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_33430</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000020">
        <property type="protein sequence ID" value="PJN07410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN07410">
        <property type="protein sequence ID" value="PJN07410"/>
        <property type="gene ID" value="CG723_33430"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007995">
        <property type="entry name" value="DUF742"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36221">
        <property type="entry name" value="PTHR36221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05331">
        <property type="entry name" value="DUF742"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN07410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="119" mass="12959" checksum="BA93A203D9431A3F" modified="2018-04-25" version="1">MTRRPVDTGDPDRLYTVTGGRSRADDDTFDLVTLVVAECEPTPGMQSEHVRILDLCRHPAAVVEIAAEMNLPITVVRILLGDLLATGRITARHPRAARSVASLPDSALLKEVLHGLRNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JKU8</accession>
    <name>A0A2M9JKU8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Acyl-CoA synthetase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_34000</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000020">
        <property type="protein sequence ID" value="PJN07500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN07500">
        <property type="protein sequence ID" value="PJN07500"/>
        <property type="gene ID" value="CG723_34000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-binding" evidence="1">
        <location>
            <begin position="15"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding_C" evidence="2">
        <location>
            <begin position="427"/>
            <end position="505"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN07500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="523" mass="57061" checksum="1B7574D949E5E72D" modified="2018-04-25" version="1">MSTGPNPNSAPPNGFWAQATADPGRTVLVAPDGEEWTAGRLHADVNRLVHGLRAAGLERGDAFAVVLPNGVEFFTAYLAASQAGFYLVPVNHHLVGPEIAWIVADSGAKVLIAHERFAEQAVAAADEAALPAGQRYAVGAIDGFRPYAQLLDGQSESVPDDRSLGWVMNYTSGTTGRPRGIRRPLPGKLPEETYLGGFLGIFGIKPFDDNVHLVCSPLYHTAVLQFAGASLHIGHTLVLMDKWTPEDMLRLIDTFRCTHTHMVPTQFHRLLALPDSVRSAYDVSAMRHAIHGAAPCPDHVKRAMIDWWGHSVEEYYAASEGGGAFATAEDWLKKPGTVGKAWPISELAVFDDDGNRLPPGELGTVYMKMSTGGFSYHKDETKTKKNRIGDFFTVGDLGILDEDGYLFLRDRKIDMIISGGVNIYPAEIESALLTHPAIADAAAFGIPNDDWGEEVKAVVEPAEGHTAGDALAAEILAHCERQLAGYKRPKSVDFIETMPRDPNGKLYKRRLRDPYWEGRTRAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-09-29" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JKY2</accession>
    <name>A0A2M9JKY2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Lipid-transfer protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CG723_32705</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000019">
        <property type="protein sequence ID" value="PJN07536.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN07536">
        <property type="protein sequence ID" value="PJN07536"/>
        <property type="gene ID" value="CG723_32705"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002155">
        <property type="entry name" value="Thiolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000429">
        <property type="entry name" value="Ac-CoA_Ac_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PJN07536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="388" mass="40456" checksum="609362F74119D799" modified="2018-04-25" version="1">MSVRAKDSLGGRAAIVGIGATEFSKDSGRSELKLAVEAVGTALDDAGLSPADVDGMVTFTMDTSPEITVAQAAGIGDLSFFSRVHYGGGAACATVHQAALAVATGVAEVVVCYRAFNERSGRRFGSGVQHREPSAEGAALGWALPFGLLTPASWVAMAAQRYLHAYGLGPEAFGHVAVMDRAYAATNPAAYFHGKPITLEDHAASRWIVEPLRLLDCCQETDGGQAIVVTSAERARDLPHRPAVITAAAQGAGRNQEQMTSFYRDDMTGLPEMGVVARQLWRSAGLTPGEIDVGILYDHFTPFVLMQLEEFGFCGPGEAADFVAEQRLPLNTHGGQLGEAYLHGMNGIAEAVRQVRGTAVNQIAGAATALVTAGTGVPTSGLILGADG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JL72</accession>
    <name>A0A2M9JL72_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">CCA tRNA nucleotidyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CG723_33120</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000019">
        <property type="protein sequence ID" value="PJN07608.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN07608">
        <property type="protein sequence ID" value="PJN07608"/>
        <property type="gene ID" value="CG723_33120"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031123">
        <property type="term" value="P:RNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="CDD" id="cd00077">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05398">
        <property type="entry name" value="NT_ClassII-CCAase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006674">
        <property type="entry name" value="HD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006675">
        <property type="entry name" value="HDIG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002646">
        <property type="entry name" value="PolA_pol_head_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032828">
        <property type="entry name" value="PolyA_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014065">
        <property type="entry name" value="tRNA_adenylyltransferase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01966">
        <property type="entry name" value="HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01743">
        <property type="entry name" value="PolyA_pol"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12627">
        <property type="entry name" value="PolyA_pol_RNAbd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00471">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="SSF81301"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00277">
        <property type="entry name" value="HDIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02692">
        <property type="entry name" value="tRNA_CCA_actino"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51831">
        <property type="entry name" value="HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="1 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="HD" evidence="4">
        <location>
            <begin position="270"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="392"/>
            <end position="419"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PJN07608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="483" mass="54375" checksum="3909A8AE02836FEB" modified="2018-04-25" version="1">MPNANEDNPSALSQVQRRAVSELLRVAPVADDLARRFREAGFSLALVGGSVRDALLGRLGNDLDFTTDARPEDVLKIVRPWADAVWEVGIAFGTVGCQKDGYLVEVTTYRSEAYDRTSRKPEVSYGDSIEEDLVRRDFTVNAMAVALPEKEFIDPHGGLDDLAERVLRTPGTPEESFSDDPLRMMRAARFAAQLDFEVAPEVVKAMKDMADRIEIVSAERVRDELNKLILSAHPREGLTLLVDTGLAAHVLPELPELRLERDEHHRHKDVYDHTLIVLEQAMALESDGPDLVLRLAALLHDIGKPKTRRFEGDGRVSFHHHEVVGAKMTKKRMTALKYSNELVKDVSRLVELHLRFHGYGTGEWTDSAVRRYVRDAGPLLDRLHKLTRSDCTTRNKRKANALERAYDGLEERIVRLKEQEELDSIRPDLDGNQIQEILGIKPGPAIGQAYKFLLELRLENGPMEHDAAVAALKEWWAAQQNAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-05-25" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JLE8</accession>
    <name>A0A2M9JLE8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">SsgA family sporulation/cell division regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CG723_32005</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CB01635</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell septum</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SsgA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000018">
        <property type="protein sequence ID" value="PJN07701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003959770.1">
        <property type="nucleotide sequence ID" value="NZ_NNBL01000018.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A2M9JLE8"/>
    <dbReference type="EnsemblBacteria" id="PJN07701">
        <property type="protein sequence ID" value="PJN07701"/>
        <property type="gene ID" value="CG723_32005"/>
    </dbReference>
    <dbReference type="GeneID" id="58431150"/>
    <dbReference type="GeneID" id="63978789"/>
    <dbReference type="GeneID" id="66959955"/>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030428">
        <property type="term" value="C:cell septum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030435">
        <property type="term" value="P:sporulation resulting in formation of a cellular spore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.31.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006776">
        <property type="entry name" value="SsgB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038658">
        <property type="entry name" value="SsgB_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04686">
        <property type="entry name" value="SsgA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4" id="KW-0132">Cell division</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0749">Sporulation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PJN07701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="137" mass="14838" checksum="753EE7C6483CA9F6" modified="2018-04-25" version="1">MNTTVSCELHLRLVVSSESSLPVPAGLRYDTADPYAVHATFHTGAEETVEWVFARDLLAEGLHRPTGTGDVRVWPSRSHGQGVVCIALSSPEGEALLEAPARALESFLKRTDAAVPPGTEHRHFDLDTELSHILAES</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-09-29" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JM76</accession>
    <name>A0A2M9JM76_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Sodium-dependent transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_30200</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000016">
        <property type="protein sequence ID" value="PJN07975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN07975">
        <property type="protein sequence ID" value="PJN07975"/>
        <property type="gene ID" value="CG723_30200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002657">
        <property type="entry name" value="BilAc:Na_symport/Acr3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004710">
        <property type="entry name" value="Bilac:Na_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038770">
        <property type="entry name" value="Na+/solute_symporter_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10361">
        <property type="entry name" value="PTHR10361"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01758">
        <property type="entry name" value="SBF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="60"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="89"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="124"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="155"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="197"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="230"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="260"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN07975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="359" mass="36903" checksum="8F9E2571EEF22FA6" modified="2018-04-25" version="1">MNTRSAARTDRATDWLRRRLGRGVVLSYAAALLLPGPGLWLRRAHSLPLGAADRLSLSTAPLLLSLVLFSAGLQVPVRTLGTLLRRPIALLAGLVLHLAIPLLAIPAVAFLLSRTPDTDGGSGLVTAMILIVAMPVAAGSTVWTGKGGGDQPTMVGLVLASTLLSPLTIPLVTSALMPLLGGGYADRLTRALHVGDGGFALVGVVLPCTAGILCRLALPAPWLRRVVGIGVPIALVGSLLLTYVNACGALGSFLAHPRPLLLAAALAVAAGVCLLSFMVGRGAARLLGLDAPAASSLTLACGMNNSSASAVLITTTLPDKPHLLLPVLAYGLLQKTAAGRVVRRQRLRDNVTHPMANTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JMC8</accession>
    <name>A0A2M9JMC8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CG723_30460</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000016">
        <property type="protein sequence ID" value="PJN08019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08019">
        <property type="protein sequence ID" value="PJN08019"/>
        <property type="gene ID" value="CG723_30460"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PJN08019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="117" mass="13894" checksum="20352ACB05CA35BE" modified="2018-04-25" version="1">MDEVIEVLRREFEAEEGSFLLRLRGDLEWDRTAFSRLERAMRTACECSQGSEKLDRWLAEGFYEIATWVPVWTSHPNFPRPTPAAYYEDCTERISDLAGWFFRGWHNYGEGYQWSDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JME8</accession>
    <name>A0A2M9JME8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Erythromycin esterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CG723_30640</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000016">
        <property type="protein sequence ID" value="PJN08043.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08043">
        <property type="protein sequence ID" value="PJN08043"/>
        <property type="gene ID" value="CG723_30640"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046677">
        <property type="term" value="P:response to antibiotic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14728">
        <property type="entry name" value="Ere-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007815">
        <property type="entry name" value="Emycin_Estase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014622">
        <property type="entry name" value="UCP036794_erythomycin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05139">
        <property type="entry name" value="Erythro_esteras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036794">
        <property type="entry name" value="UCP_erythr_ester"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PJN08043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="400" mass="43520" checksum="E1B2C30A65F016CB" modified="2018-04-25" version="1">MATDIKDTAHAVEAAAVMRLLPTRPRLLALGEPTHGEDALLDVRNELFRQLVEQEGFRTIAIESDCMMGLVVDDYVTTGTGTLDAVMAHGFSHGWGESAANRELVRRMRAHNEGRPESERLRFAGFDGPLEITGAASPRQALTALHGYLSAWADASLLPCTAETLDRLLGADAPWTNPAAMLDPAESVGQSAEARELRLLADDLVALFDEQTPHLIAATSRDDWDRARLYGRTATGLLRYHFWMAHNSPSRMTRLVGLRDSMMAANLLALAERDPALVHAHNGHLQRDKSTMRMGGQSLEWWSAGALVNSQLGEGYAFLATALGTIQHQGVDTPPPDTVEGLLYALQEDLNVVDAHGLTAALGDTRPTARVSPYYGYAPLDPAHLDGYDGIVFVKDVPRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-09-29" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JMH7</accession>
    <name>A0A2M9JMH7_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Sarcosine oxidase subunit alpha</fullName>
            <ecNumber evidence="3">1.5.3.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CG723_30750</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CB01635</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>H2O + O2 + sarcosine = formaldehyde + glycine + H2O2</text>
            <dbReference type="Rhea" id="RHEA:13313"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:16842"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:57433"/>
            <dbReference type="EC" id="1.5.3.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the GcvT family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.5.3.1" evidence="3"/>
    <dbReference type="EMBL" id="NNBL01000016">
        <property type="protein sequence ID" value="PJN08062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08062">
        <property type="protein sequence ID" value="PJN08062"/>
        <property type="gene ID" value="CG723_30750"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008115">
        <property type="term" value="F:sarcosine oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046653">
        <property type="term" value="P:tetrahydrofolate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.440">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042204">
        <property type="entry name" value="2Fe-2S-bd_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013977">
        <property type="entry name" value="GCV_T_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006222">
        <property type="entry name" value="GCV_T_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029043">
        <property type="entry name" value="GcvT/YgfZ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006277">
        <property type="entry name" value="Sarcosine_oxidase_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041117">
        <property type="entry name" value="SoxA_A3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027266">
        <property type="entry name" value="TrmE/GcvT_dom1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01571">
        <property type="entry name" value="GCV_T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08669">
        <property type="entry name" value="GCV_T_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17806">
        <property type="entry name" value="SO_alpha_A3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037980">
        <property type="entry name" value="SoxA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101790">
        <property type="entry name" value="SSF101790"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01372">
        <property type="entry name" value="soxA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="2 3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyr_redox_2" evidence="5">
        <location>
            <begin position="123"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="domain" description="SO_alpha_A3" evidence="7">
        <location>
            <begin position="468"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="domain" description="GCV_T" evidence="4">
        <location>
            <begin position="569"/>
            <end position="835"/>
        </location>
    </feature>
    <feature type="domain" description="GCV_T_C" evidence="6">
        <location>
            <begin position="859"/>
            <end position="948"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR037980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF17806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PJN08062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="956" mass="101542" checksum="3062BA5FCDC556FB" modified="2018-04-25" version="1">MTDQQFRLGDAGRVDRTTLLHFTLDGRELTGRPGDTLASAMLANGIVEAAPSLYLGRPRGIVSAGVEEPNALVQLGGSCSEGMLPATTVELYDGLSATTLSGMGRLDPTPDPAVYDKKYVHTDVLVVGAGPAGLSAAAAAAESGARVILVDDQPELGGALLSGRTQPEWVAEVRAALDAAPEVTVLSRTTAFGSYDDNYVLALERRTDHLGADAPDPSSGVSRQRLWHIRVRQVVLATGAHERPLIFAGNDRPGVMLAASVRTYINRYGVTPGRRAVVGTTNDSAYDTVADLHAAGIDVAAVVDARPELSQRAAEIAATTGVRVLTGSAVVDTAGESRLTGVTVQALDADGQLVGKAEEFDCDLLAVSGGWSPVVHLHSQRQGKLRWDDDLVAFVPDGTVRHQQIVGSAQGTHGLDGALAEGARAGALAATEAGFPVPVPAAPSEDARPDVRALWLVPSPAGEPGTWDTHFVDLQRDVTAADVWRSTGAGMRGVEHVKRYTSLGTANDQGKTSGVNAIGVIAEALGAGASPGEIGTTAYRAPYTPVAFAALAGRERGDLFDPERTTSIHGWHVAHGAEFEDVGQWKRPWYYPRPGEDMDAAVARECRAAREGVAFMDATTLGKIEIWGADAGEFLNRVYTNAFKKLKPGMARYGVMCKPDGMIFDDGVTLRLDENRYFMTTTTGGAAGVLDWLEEWLQTEWPELDVHCTSVTEQWATVAVVGPKSRDVIAKLAPELDVSAGAFPFMAFRETTLASGIAARVCRISFSGELAFEINVSAWYGRSVWEQVHEAGQPYDITPYGTETMHVLRAEKGFIIVGQDTDGTVTPQDANMDWVVSKRKDFIGNRSYSRADTTRADRKQLVGLLPTDRTTRLPEGSQLIAQDTPLTPGAGPVPMLGHVTSSYHSAALGRPFALALVAGGRARIGSTLLAPVGDDLVPVEVTDSVLYDPEGTKRDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JMT0</accession>
    <name>A0A2M9JMT0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Peptide ABC transporter substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CG723_29655</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000015">
        <property type="protein sequence ID" value="PJN08173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08173">
        <property type="protein sequence ID" value="PJN08173"/>
        <property type="gene ID" value="CG723_29655"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042597">
        <property type="term" value="C:periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030678">
        <property type="entry name" value="Peptide/Ni-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039424">
        <property type="entry name" value="SBP_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000914">
        <property type="entry name" value="SBP_5_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30290">
        <property type="entry name" value="PTHR30290"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00496">
        <property type="entry name" value="SBP_bac_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002741">
        <property type="entry name" value="MppA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015000079" evidence="2">
        <location>
            <begin position="20"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="domain" description="SBP_bac_5" evidence="3">
        <location>
            <begin position="86"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="26"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="42"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PJN08173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="544" mass="58647" checksum="AA4309031B03140C" modified="2018-04-25" version="1">MRGATHAKWAVCAVAVALAATACGGGSDSGGSGGDGSGIVRSSWGDPQNPLEPANTNEVQGGKVLDMVFRGLKRYNPKTGAAEDMLADKIETTDSVNFKITVKDGWTFSNGEKVTAKSFVDAWNYGADLKNNQKNAYFFGQIDGYDKVHPDSGTPSATSLSGLKVTGPLTFSVKLSQKFSLWPDTLGYAAFAPLPKAFFDDHDAWVSKPVGNGPYTIDSYTKGSQMSLRKWDAYPGTDKAQNGGVDLKVYTDNNTAYTDLTAGNLDLVDDVPASQLKNVEADLGGRYINSPAGIIQTLAFPFYDPAWNKADSDKVRKGLSMAINRKQITETIFQKTRTPATDWTSPVLGKDGGFQDGLCGDGCDYNPTEAKKLVQEGGGIPGGQVKIGYNADTGSHKEWVDAVCNSINNALGNDNACVGLPTGTFADFRNKITQKKMTGPFRAGWQMDYPLIQNFLQPLYYTNASSNDGKWSNKEFDKLVDQANAESDRAKAVKIFQQAEGVVRDNMAAIPLWYQNGSAGYSDKVSNVALNPFSVPVYNEIKVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JN67</accession>
    <name>A0A2M9JN67_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CG723_28330</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CB01635</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LytR/CpsA/Psr (LCP) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000014">
        <property type="protein sequence ID" value="PJN08305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08305">
        <property type="protein sequence ID" value="PJN08305"/>
        <property type="gene ID" value="CG723_28330"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004474">
        <property type="entry name" value="LytR_CpsA_psr"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03816">
        <property type="entry name" value="LytR_cpsA_psr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00350">
        <property type="entry name" value="lytR_cpsA_psr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014754212" evidence="2">
        <location>
            <begin position="32"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="domain" description="LytR_cpsA_psr" evidence="3">
        <location>
            <begin position="86"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PJN08305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="358" mass="38602" checksum="7116CB41C7320457" modified="2018-04-25" version="1">MSRRRKVPLGAAVLGVLLATAVSVADNSVSALPGRIQRVDAFNGAVNRPAEGPGTNILLMGTDGRDTISSQEKKKFHADGFACGCTDSLMLIHVSQRRDHVSVASLPRDSLAQIPAHRDPGTGEQFPAHPAKINAAFAEGGPALSVRTVEAMTNVRVDHYLQIDFRRFMDSVNAVEGVDVCTPRRLSDSATKLDLRPGRHRLGGGKALQYVRSRHVDASADLGRIQRRHRFLVGVMHRLDTARILTDPGRGIDLARTVLGSTKVDQGFTPEELIDLGSEVSRLPAAQTEFTVVPIAGFNPVIEGVGTTPAWDEAAAEKTFARLNRDRTLTPRDSTAQPFDPPRIGAETAVRGNTLACF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JNA8</accession>
    <name>A0A2M9JNA8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">RdlA protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_28345</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000014">
        <property type="protein sequence ID" value="PJN08307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08307">
        <property type="protein sequence ID" value="PJN08307"/>
        <property type="gene ID" value="CG723_28345"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014864067" evidence="1">
        <location>
            <begin position="29"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN08307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="136" mass="13433" checksum="284714EFDFD8E340" modified="2018-04-25" version="1">MLKKAMAAAAVAVSVVGVSAASASQALAIGDDGGTTSNSGNGASQVYGNSATYGKMSPQLGLIQGSLNKPCIALPVKGNAGGVAGVVPVGIHDIPILSAPQNQQCVENSTQAKGDEPLSHILDDFPILSGNGAHNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JNB7</accession>
    <name>A0A2M9JNB7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_28675</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000014">
        <property type="protein sequence ID" value="PJN08362.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08362">
        <property type="protein sequence ID" value="PJN08362"/>
        <property type="gene ID" value="CG723_28675"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014487">
        <property type="entry name" value="DUF3151"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11349">
        <property type="entry name" value="DUF3151"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017349">
        <property type="entry name" value="UCP017349"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN08362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="137" mass="14850" checksum="F074EC0B52BD9195" modified="2018-04-25" version="1">MSLHENLLGGPPPTELPDDPEPRELLASGTAPADVAAKYPTSSLAWARLADEAYERGSVVESYAYARTGYHRGLDSLRRAGWKGHGPVPWEHEPNRGFLRALHALARAAQSIGEQAEYERCAQFLKDSSPAAAQTLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JNH0</accession>
    <name>A0A2M9JNH0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Polyketide cyclase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_28960</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000014">
        <property type="protein sequence ID" value="PJN08410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08410">
        <property type="protein sequence ID" value="PJN08410"/>
        <property type="gene ID" value="CG723_28960"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037401">
        <property type="entry name" value="SnoaL-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12680">
        <property type="entry name" value="SnoaL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="SSF54427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SnoaL-like" evidence="1">
        <location>
            <begin position="11"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12680"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN08410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="125" mass="13129" checksum="2066E4ABA5009475" modified="2018-04-25" version="1">MSVISVHEAAVTRYFEAWNAEGADARAEAVAAAWSEDGSYTDPLADVAGHEGIAAVIAAAREQFPGFAFRRTGTVDGHHDVARFTWELVSTADGSAPVAGSDVISLAKDGRIRTVQGFLDRVPAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JPB9</accession>
    <name>A0A2M9JPB9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_26800</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000012">
        <property type="protein sequence ID" value="PJN08706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08706">
        <property type="protein sequence ID" value="PJN08706"/>
        <property type="gene ID" value="CG723_26800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043917">
        <property type="entry name" value="DUF5753"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19054">
        <property type="entry name" value="DUF5753"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="18"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN08706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="273" mass="31165" checksum="3E557F94C409E334" modified="2018-04-25" version="1">MASNVNPTVRRRRLGQELRRLRELKGMTAEEVAERLLVSQSKISRLENGRRSISQRDVRDLCGVYEVEDHRIVDSLMQMAKDSRQQGWWHSFGDIPYSVYIGLETDAASLRVYDPQVVPGLLQTRAYAETLITGALPETTPTDIDKRVQVRVRRQERIVAPDNPLRLWTVLDESALRRVVGSRTVMREQLEHLVEQSQLPHVTVQVIPFDMGAHPGLNGQYAILEFPDAADSSVVYIEGVTSDLYLEKANDVQKYSVMYEHLRAQALNVEQSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JPP9</accession>
    <name>A0A2M9JPP9_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Thiamine_BP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_25460</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0045 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000011">
        <property type="protein sequence ID" value="PJN08848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08848">
        <property type="protein sequence ID" value="PJN08848"/>
        <property type="gene ID" value="CG723_25460"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.930">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029756">
        <property type="entry name" value="MTH1187/YkoF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002767">
        <property type="entry name" value="Thiamine_BP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01910">
        <property type="entry name" value="Thiamine_BP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89957">
        <property type="entry name" value="SSF89957"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00106">
        <property type="entry name" value="TIGR00106"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thiamine_BP" evidence="2">
        <location>
            <begin position="3"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN08848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="98" mass="10455" checksum="1CE419CA04FDB79E" modified="2018-04-25" version="1">MIVAFSVSPLGVGEDVGEYVADAVRVVRESGLPNRTDAMFTSIEGEWDEVMDVVKRAVAAVEARAPRVSLVLKADIRPGVTDGMTSKVATVERHLAGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JPV2</accession>
    <name>A0A2M9JPV2_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 4">Diaminopimelate decarboxylase</fullName>
            <shortName evidence="3">DAP decarboxylase</shortName>
            <shortName evidence="3">DAPDC</shortName>
            <ecNumber evidence="3 4">4.1.1.20</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3 7" type="primary">lysA</name>
        <name evidence="7" type="ORF">CG723_25745</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CB01635</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Specifically catalyzes the decarboxylation of meso-diaminopimelate (meso-DAP) to L-lysine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3 4">
            <text>H(+) + meso-2,6-diaminoheptanedioate = CO2 + L-lysine</text>
            <dbReference type="Rhea" id="RHEA:15101"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:32551"/>
            <dbReference type="ChEBI" id="CHEBI:57791"/>
            <dbReference type="EC" id="4.1.1.20"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 3 4">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 4">Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; L-lysine from DL-2,6-diaminopimelate: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the Orn/Lys/Arg decarboxylase class-II family. LysA subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.20" evidence="3 4"/>
    <dbReference type="EMBL" id="NNBL01000011">
        <property type="protein sequence ID" value="PJN08898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08898">
        <property type="protein sequence ID" value="PJN08898"/>
        <property type="gene ID" value="CG723_25745"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00034">
        <property type="reaction ID" value="UER00027"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008836">
        <property type="term" value="F:diaminopimelate decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009089">
        <property type="term" value="P:lysine biosynthetic process via diaminopimelate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06828">
        <property type="entry name" value="PLPDE_III_DapDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.37.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02120">
        <property type="entry name" value="LysA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009006">
        <property type="entry name" value="Ala_racemase/Decarboxylase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002986">
        <property type="entry name" value="DAP_deCOOHase_LysA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022643">
        <property type="entry name" value="De-COase2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022657">
        <property type="entry name" value="De-COase2_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022644">
        <property type="entry name" value="De-COase2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022653">
        <property type="entry name" value="De-COase2_pyr-phos_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000183">
        <property type="entry name" value="Orn/DAP/Arg_de-COase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029066">
        <property type="entry name" value="PLP-binding_barrel"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02784">
        <property type="entry name" value="Orn_Arg_deC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00278">
        <property type="entry name" value="Orn_DAP_Arg_deC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01181">
        <property type="entry name" value="DAPDCRBXLASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01179">
        <property type="entry name" value="ODADCRBXLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50621">
        <property type="entry name" value="SSF50621"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51419">
        <property type="entry name" value="SSF51419"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01048">
        <property type="entry name" value="lysA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00878">
        <property type="entry name" value="ODR_DC_2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00879">
        <property type="entry name" value="ODR_DC_2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="3 4" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="3 4" id="KW-0456">Lyase</keyword>
    <keyword evidence="2 3 4" id="KW-0457">Lysine biosynthesis</keyword>
    <keyword evidence="3" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Orn_Arg_deC_N" evidence="6">
        <location>
            <begin position="72"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="domain" description="Orn_DAP_Arg_deC" evidence="5">
        <location>
            <begin position="334"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="region of interest" description="Pyridoxal phosphate binding" evidence="3">
        <location>
            <begin position="320"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="278"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="323"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="360"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="364"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="392"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="421"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="3">
        <location>
            <position position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02784"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PJN08898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="463" mass="49873" checksum="DB77045579605C19" modified="2018-04-25" version="1">MSRSAHPAGPRHADVLTEGHYAAPPADLNALDPKVWSQTVTREGDGAVRVGGIEVARLAEEFGTPAYFLDEDDFRARCRAWRDAFGPDADVFYAGKAFLSRAVVRWLDEEGLNLDVCSGGELATALSAGMPPARIAFHGNNKSEAEIERAVEVGVGRIVLDSFQEIVRVSHIAERLGKRQPVQIRVTVGVEAHTHEFIATAHEDQKFGIALAGGQAAEAVRRALKLDGLELIGIHSHIGSQIFDMAGFEVAARRVVSLLAEVRDEHGVELPEIDLGGGLGIAYTSDDDPSEPHEIAKALGEIVTRECEAAGLRTPRISVEPGRAIVGPTAFTLYEVGTIKPLETLRTYVSVDGGMSDNIRTALYDAEYTVALVSRRSDAEPMLVRVVGKHCESGDIVVKDAFLPADLAPGDLLAVPATGAYCRSMASNYNHALRPPVVAVRDGEARVIVRRETEEDLLRLDVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JQJ0</accession>
    <name>A0A2M9JQJ0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_24310</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000010">
        <property type="protein sequence ID" value="PJN09057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN09057">
        <property type="protein sequence ID" value="PJN09057"/>
        <property type="gene ID" value="CG723_24310"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="39"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="103"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="143"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="186"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="216"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="303"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN09057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="337" mass="35988" checksum="3632222BFCDB8DC5" modified="2018-04-25" version="1">MTTLIDNAGNTTGRPAARRTLPGPDGLVWTVLRLHRTALWVWTAYVVITAGLLLWLWGPGASAAQKAFDVFGYSGAQDNAYQGSAPVILIGGSFDSFFYEPSSLIGIASCAIAVFAAGPLIARELELGTAQLAWTQSVSPARWLAAKLAVPAVFVGVGTGLIVVLYRLVWNAHNHLLVAGIGPRSFYFSIGPATVATALFGLAVGVLAALVLRRTLPALVVAGVVQLLAGALRGNNWPFQHSPFSRLQPELPVYSKAITSSGAKVSDPGCYLSQKCLDRHDITGFTRTYLHSPDYWPRQLAETGILIALTALAVVGAFLVLRRYQARTHQPKKETAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JRB0</accession>
    <name>A0A2M9JRB0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Sugar ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CG723_23945</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CB01635</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000009">
        <property type="protein sequence ID" value="PJN09382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN09382">
        <property type="protein sequence ID" value="PJN09382"/>
        <property type="gene ID" value="CG723_23945"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="38"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="101"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="133"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="184"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="243"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="290"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="97"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PJN09382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="320" mass="34190" checksum="D2FBC541F60AB187" modified="2018-04-25" version="1">MTTVDVRRPDAVRDGIPAPVSRPADRRTSRTASGRRPWLGLAYLAPALIVYAVVVLVPAVQGGYVSFFDWDGVTPARWNGLGNYAAFVNDPVLRQAIEHTLVFLVFFSFLPIVLGLVSAALTSRKDVRGSAVFRWVIFLPQVLTPAVTAIVWKQIYAPQGPVNSVLRAIGLGALAQGWLSDYTWALPALGLIGTWGAFGLCTVLFVAGTQAIPTELYDAVRVDGAGPVREFFAITLPGLRGHLAIVLTLTTLGAIRVFDVVWLTTHGGPGTSTVTPTTVLYERAFANPDIGTAAAVGVVIALVSLAVSMAILRLSEDRSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JRC2</accession>
    <name>A0A2M9JRC2_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CHAT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_24025</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000009">
        <property type="protein sequence ID" value="PJN09394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN09394">
        <property type="protein sequence ID" value="PJN09394"/>
        <property type="gene ID" value="CG723_24025"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024983">
        <property type="entry name" value="CHAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12770">
        <property type="entry name" value="CHAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CHAT" evidence="2">
        <location>
            <begin position="939"/>
            <end position="1226"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN09394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="1227" mass="132166" checksum="2EDBF5F1E746D407" modified="2018-04-25" version="1">MLIPGDHPTGVPASYAETRRDEEGSMGRRDELLLSLGELVQRIGDTGDAAMAWSPQVIAVAQDLTEELDEAEGWDIPVRQALGWLKWYQACASLGEERQRAVDEALQVFAPAAMVIGMVPFPEPLLPGLADEAATRLPAMLEYALSSPDDDQFAALVDTSIHIANATPGGHPQRAHRLAVVCHALISRSARNGQFIRLEQALAAARQGVVHSRPDDPDRAAMMSVFAAVLFNGFNLSGAVADLDEAIEAAREAVSSGKGRPGERIRLVVLADMLWTRFQLTDSVADLDEVTEVRSSLAEASKVTDAGCSEQFTLLGQALLTRFDIRHDPADLDGTVNALRGAVSAATTDEERLYCRSDLSCVLQRRFERCGARADLDEAADAAREAAAEAPAACSPSLLTSLAIVLDFCARTTGSLDDLDTAIGLVRRAAAATPAGYSRTKRPELGIIQAHVPDVMEGATAEYEPSRPELQRLLCAYLTRRFERTDVLADIDALVEARREALATGGVDGRDDGDRARNLALLSYALKLRFHRVGRSEDLEEAVTTIQQALSIQPGDGDFLSSLSDTFRVRFVEYRDKADLDQAVQLARRATQVCAGDLLPAVAFANLSQVLQTRFGLFRDRPDVDEAVNAARAAVTAEGDGAQRPKWLLILGESLLARVGARRLSDDESGRETDRAEALRALSELVMRSDSAPPRLKVHGAKLGAWLAAVELPPGSEDFALAADLLEAAVLALPELAPRRMRREEQQETMETASGIAGDAAAMVLSDPLRPPAERARRALSLLEMGRSVLLSRRLHARRDLAGLHEAGPELAARFAALCDLLDGDVEQAPTGQDRIGAAAELAATLRRIRALDGFAHFALPPTDEELLSAADRGPVVSLNVAYRGDALLLTAEGNTALGLPGVTAETVIDQINAFHVALREARDPHRDRVAAQHALSQVLKWLWDNITGPVLDALGHHGPPADGAPWPRVWWAPGGYLSLLPLHAAGHHDDPAEGRRTVMDRVVSSYTPTISALRHARRRQSTSAPAASSALIVAMPETPGLAGLRNVAPEAELVRDLLPDSLLLTAPDRAQVLAQLPGRTIAHFACHGSFDPDDPSAGRLLLNDHGQHPLTVADLYSVDLDGAQLAYLSACHTAVNSAERLLDEGIHLVGALQTAGFPQVVGTMWELDDEIAEEITEDFYSLLREPHSGGLDLRTAGHALHHAVRKQRDRYPGTPSLWASHLHFGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JRL8</accession>
    <name>A0A2M9JRL8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Isochorismatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_22465</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000008">
        <property type="protein sequence ID" value="PJN09513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN09513">
        <property type="protein sequence ID" value="PJN09513"/>
        <property type="gene ID" value="CG723_22465"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.850">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000868">
        <property type="entry name" value="Isochorismatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036380">
        <property type="entry name" value="Isochorismatase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00857">
        <property type="entry name" value="Isochorismatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52499">
        <property type="entry name" value="SSF52499"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Isochorismatase" evidence="1">
        <location>
            <begin position="4"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN09513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="178" mass="19892" checksum="257300A5BC8212A7" modified="2018-04-25" version="1">MGKTALIVIDMINSYDHADAELLVSSARDALPAVVRLIRNAREEDIPVIYVNDNFGEWRSHHGEILETALAGPHADLVDPIRPDDDSLFIVKARHSIFFETPLGYLLSQLGVDRVVLCGQVTEQCVLYSALDAHIRHLRVTVVHDAVAHIYPDLAEAALRLMERNMSADIRKVDEVSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JRR8</accession>
    <name>A0A2M9JRR8_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 5">Beta-galactosidase</fullName>
            <shortName evidence="5">Beta-gal</shortName>
            <ecNumber evidence="3 5">3.2.1.23</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CG723_22815</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CB01635</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 5">
            <text>Hydrolysis of terminal non-reducing beta-D-galactose residues in beta-D-galactosides.</text>
            <dbReference type="EC" id="3.2.1.23"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the glycosyl hydrolase 42 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.23" evidence="3 5"/>
    <dbReference type="EMBL" id="NNBL01000008">
        <property type="protein sequence ID" value="PJN09571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN09571">
        <property type="protein sequence ID" value="PJN09571"/>
        <property type="gene ID" value="CG723_22815"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009341">
        <property type="term" value="C:beta-galactosidase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004565">
        <property type="term" value="F:beta-galactosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006012">
        <property type="term" value="P:galactose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013739">
        <property type="entry name" value="Beta_galactosidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013738">
        <property type="entry name" value="Beta_galactosidase_Trimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003476">
        <property type="entry name" value="Glyco_hydro_42"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013529">
        <property type="entry name" value="Glyco_hydro_42_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36447">
        <property type="entry name" value="PTHR36447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02449">
        <property type="entry name" value="Glyco_hydro_42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08533">
        <property type="entry name" value="Glyco_hydro_42C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08532">
        <property type="entry name" value="Glyco_hydro_42M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001084">
        <property type="entry name" value="B-galactosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glyco_hydro_42" evidence="8">
        <location>
            <begin position="14"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_hydro_42M" evidence="9">
        <location>
            <begin position="392"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_hydro_42C" evidence="10">
        <location>
            <begin position="600"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="6">
        <location>
            <position position="150"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="6">
        <location>
            <position position="303"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="111"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="149"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="311"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001412"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR001084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR001084-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR001084-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF08532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF08533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PJN09571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="665" mass="74081" checksum="8F7958F9FBF72083" modified="2018-04-25" version="1">MTIAHDGRLLYGGDYNPEQWPEEVWADDVRLMKEAGVTSVTLGVFSWAKLEPTPGAREFGWLDRLMDLMHSHGIGVVLATPTASPPPWLGRLHPETLPRDENGQTMWWGSRQQFAHSSSAYRRHAAAITEDLAIRYGHHPALRMWHINNEYCTFDYGDEAAHAFRDWLRAKYGTLDTLNEAWGTTFWSQHVETWADVIPPRRAQYLHNPAQVLDFRRFTSDALLECYTAERDIVRRHSPARVPVTTNFMPFWIGQDAWAWAEREDVVSVDVYPDPRDPLGGQYNAMIADMTRSQARGPWMVMEQAAGPVNWRGVNHPKPRGLNRLWSLQTVARGADAVCYFQWRQSRQGAEKFHSGMVGHAGEEGRAFAEVKQIGAELAELGSQVPGTRIAADVAVLHDWHSWWAGCQDGRPSAHVAYEDVVRSWHRALWEAHLATDFAHPEHDLSAYKLVVVPHLYLLTDAAIENLVSYVRGGGTLVSGFFTGVADADDRVRPGGMDARLRALFGIRTVHEWWPLDPDETVDCGEFTGTLWSEELTAEPGTEVSAVYRGGELDGLPAVLRRGRARYLSTLPEPPALRSLLEDVAAEAGVRPPLSGLPAGVEAVRRGELLFLLHHGRGEVTVALPDDTTYRDLLTGAEHYGSVTLGRFGVAVLALGTTTRGHSAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-09-29" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JS58</accession>
    <name>A0A2M9JS58_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CG723_21195</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000007">
        <property type="protein sequence ID" value="PJN09721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN09721">
        <property type="protein sequence ID" value="PJN09721"/>
        <property type="gene ID" value="CG723_21195"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PJN09721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="490" mass="54324" checksum="8A931E327422B608" modified="2018-04-25" version="1">MGGSDGSVTNAEKRPNELLSSWFLRSGWSKGELARQVNRRARQLGANHISTDTSRVRRWLDGENPREPIPRILSELFSERFGCVVAVEDLGLRAAHQSPSVSGVDLPWTGPQTVALIGEFSRSDLMLARRGFLGSALALSAGPALIEPMQRWLVPTPGTPVVEPDPAALRRGNRLSKPELDLLESTTVMFRQWDAQCGGGLRRKAVVGQLHEVTDLLQEPQPAATTKRLFKVAAELAELAGWMSYDVGLQPTAQKYFVLALHAAKEAGDKPLGSYVLSSMSRQMIHLGRPDDALELVHLAQYGSRDCASPRTQAMLYAMEARAYANIGQPGKCKRAVRMAEETFHDADDWDDPDPDWIRFFSEAELHGENSHSYRDLAYVAGRSPTYASMSEPVMRRAVELFEKDSEHQRSYALNLIGMATVHLLQREPEQSTVLAEQAMIIAKKVRSERVNTRIRKTVDTAVREFGDVAEVAHLTDQLAIHLPETAEAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JS80</accession>
    <name>A0A2M9JS80_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">SCP-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CG723_21150</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000007">
        <property type="protein sequence ID" value="PJN09712.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN09712">
        <property type="protein sequence ID" value="PJN09712"/>
        <property type="gene ID" value="CG723_21150"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.33.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014044">
        <property type="entry name" value="CAP_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035940">
        <property type="entry name" value="CAP_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00188">
        <property type="entry name" value="CAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55797">
        <property type="entry name" value="SSF55797"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="108"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="domain" description="SCP" evidence="3">
        <location>
            <begin position="255"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="145"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="151"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PJN09712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="371" mass="37284" checksum="EE642D18BC3A7CC4" modified="2018-04-25" version="1">MGRHRRADAGRAATGRATDSTAGSHAGHDGTYKAGYNGAYDGAHAETYTPDGFTSPYNASPHTTANGDLGWAFDDVYPGEPEAAYTPSGSPGGSHRHRKRVARPVRTGLLGVSAAVAMGAVAVASGVVPGMDNYSLGGGADKVRAADSPSGLETQGGTDGSADRAPSSASRSAERSDSPSASPSQSSSKPSSNPSKTASTSKSSSSASDSDSGGAATSPKTATPPKTATTKPQPPAAAPSLKAPSGEASAEAQVLALVNTERAKAGCGPVTADGGLAALAGNFSEDMAARGFFDHTDPDGATPWDRAKKAGITDLGGENIARGQANAQSVMDSWMNSPGHRANILNCDYKTLGVGVHFGSGGPWWTQDFGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JS82</accession>
    <name>A0A2M9JS82_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RNA polymerase sigma factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CG723_21350</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CB01635</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the sigma-70 factor family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000007">
        <property type="protein sequence ID" value="PJN09751.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN09751">
        <property type="protein sequence ID" value="PJN09751"/>
        <property type="gene ID" value="CG723_21350"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed 5'-3' RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000943">
        <property type="entry name" value="RNA_pol_sigma70"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007624">
        <property type="entry name" value="RNA_pol_sigma70_r3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007630">
        <property type="entry name" value="RNA_pol_sigma70_r4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012845">
        <property type="entry name" value="RNA_pol_sigma_FliA_WhiG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04539">
        <property type="entry name" value="Sigma70_r3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04545">
        <property type="entry name" value="Sigma70_r4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000770">
        <property type="entry name" value="RNA_pol_sigma-SigE/K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00046">
        <property type="entry name" value="SIGMA70FCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02479">
        <property type="entry name" value="FliA_WhiG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00715">
        <property type="entry name" value="SIGMA70_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00716">
        <property type="entry name" value="SIGMA70_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0731">Sigma factor</keyword>
    <keyword evidence="4 5" id="KW-0804">Transcription</keyword>
    <keyword evidence="1 5" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="RNA_pol_sigma70" evidence="7">
        <location>
            <begin position="75"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="domain" description="RNA_pol_sigma70" evidence="8">
        <location>
            <begin position="243"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS00715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS00716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PJN09751.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="278" mass="30985" checksum="08EF1F1471EDABEE" modified="2018-04-25" version="1">MPQHTSGSDRAAVPPAARGSVRPPAPSSLEELWRSYKTTGDGRLREQLILHYSPLVKYVAGRVSVGLPPNVEQADFVSSGVFGLIDAIEKFDIEREIKFETYAITRIRGAMIDELRALDWIPRSVRQKARNVERAYATLEAQLRRTPSESEVAAELGIRVEELHAVFSQLSLANVVALEELLHAGGESGDRLSLMDTLEDHAADNPVEVAEDRELRRYLARAINTLPEREKTVVTLYYYEGLTLAEIGNVLGVTESRVSQIHTKSVLQLRAKLAGFRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JSZ5</accession>
    <name>A0A2M9JSZ5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">RNA polymerase subunit sigma-24</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CG723_20060</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CB01635</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000006">
        <property type="protein sequence ID" value="PJN10016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN10016">
        <property type="protein sequence ID" value="PJN10016"/>
        <property type="gene ID" value="CG723_20060"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050896">
        <property type="term" value="P:response to stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013249">
        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08281">
        <property type="entry name" value="Sigma70_r4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="5">
        <location>
            <begin position="20"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4_2" evidence="6">
        <location>
            <begin position="121"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PJN10016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="421" mass="45312" checksum="19F5B1F7F7F53689" modified="2018-04-25" version="1">MTAERTAGAAHAIETVFRLEAPRIIAGVTRIVRDVGIAEELAQDALVAALEQWPVEGVPDNPGAWLMATAKHRAIDLVRRKERYARKLAEVGRDLEAAPPHLDEPADPDDIDDDLLRLVFTACHPVLSAEARVALTLRLLGGLTTAEIARAVLAPEATVAQRIVRAKRTLATKNVAFEVPYGPERAARLGSVLEVIYLIFNEGYAATAGDDYLRPGLCEDALRLARLLAGLMPKEPEVHGLASLLELQASRSAARTGPSGEPVLLRDQDRTRWNQLLIRRGFAALGRADAVSTGGGPGPYALQAAIAASHAHAHTYAETNWQGIATLYGLLATRAPSPVVELNRAVAVSMAEGPAAGLVLVDALAGEPALRDYHLLPSVRGDLLERLGRYEEARAEFERAASLTRNERERGLLLARAEGCR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-09-29" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JT04</accession>
    <name>A0A2M9JT04_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Glycoside hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CG723_19855</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CB01635</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C40 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000006">
        <property type="protein sequence ID" value="PJN09983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN09983">
        <property type="protein sequence ID" value="PJN09983"/>
        <property type="gene ID" value="CG723_19855"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000064">
        <property type="entry name" value="NLP_P60_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00877">
        <property type="entry name" value="NLPC_P60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="SSF54001"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51935">
        <property type="entry name" value="NLPC_P60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014618176" evidence="3">
        <location>
            <begin position="40"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="domain" description="NlpC/P60" evidence="4">
        <location>
            <begin position="272"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="67"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="224"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="72"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="224"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="251"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PJN09983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="387" mass="41704" checksum="9BDCD77D613FE7D4" modified="2018-04-25" version="1">MASHRKPRTRTAGPRTAPVAGITTAALTSIALLSQTATAAPSAPPKPSLEEVQKKVDTLYHQAGVATEKYNAAKERTTKQQKRVGELHDDVAQRTEKLNKARQELGTFAAAQYRTGAVSDTATLLLADDAQDYFDQDQLMSRLTSRQKKAVDDYQTEQAATTKKRTEAAKSLETLTTSQATLKSTKRDVQQKLGDARELLSKLTAEEKARLAAIEKKKQEAARKKAEELARQQAEAEAKRKAAEEARQKENPGTGTGSGTGTGSGSTSSGYATKAAKVIDFAESQMGKPYVWGATGPDSYDCSGLTQAAWKAAGITLPRTTWDQVKVGTTVTTADAEPGDLVFFYDDISHVGIYIGDGKMIHAPKPGANVRVESIYYMPIHSVVRPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JT15</accession>
    <name>A0A2M9JT15_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Succinate dehydrogenase, cytochrome b556 subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">sdhC</name>
        <name evidence="9" type="ORF">CG723_19520</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CB01635</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000006">
        <property type="protein sequence ID" value="PJN09927.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN09927">
        <property type="protein sequence ID" value="PJN09927"/>
        <property type="gene ID" value="CG723_19520"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045281">
        <property type="term" value="C:succinate dehydrogenase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000104">
        <property type="term" value="F:succinate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1300.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039023">
        <property type="entry name" value="SdhC_prok"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034804">
        <property type="entry name" value="SQR/QFR_C/D"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014314">
        <property type="entry name" value="Succ_DH_cytb556"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000701">
        <property type="entry name" value="SuccDH_FuR_B_TM-su"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41910">
        <property type="entry name" value="PTHR41910"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01127">
        <property type="entry name" value="Sdh_cyt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81343">
        <property type="entry name" value="SSF81343"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02970">
        <property type="entry name" value="succ_dehyd_cytB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0349">Heme</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="21"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="54"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="96"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PJN09927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="126" mass="14169" checksum="F4266C4495DAC7F1" modified="2018-04-25" version="1">MPAGTLYRGREGMWSWVAHRVTGVLIFFFLFVHVLDTALVRVSPESYDDVVSTYKTPIVALLEYGLVAAILFHALNGLRVIAVDFWSKGPRYQKQMLWTVVGIWVVLMVGALYPVLGHAVRELFGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JT81</accession>
    <name>A0A2M9JT81_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CG723_19875</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000006">
        <property type="protein sequence ID" value="PJN09987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN09987">
        <property type="protein sequence ID" value="PJN09987"/>
        <property type="gene ID" value="CG723_19875"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PJN09987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="240" mass="26064" checksum="A0228B249FBD315F" modified="2018-04-25" version="1">MGYGATAGVTGGVTTRLPQSALSSGAIFHLVGLAADAAGSGDPLEWQVLRYRRIQGVEYTRPSWTWPLQPAAAQLDHLAHTFTEEFFSTCPPAARTLWSRAAGTRTVPEFMNDLATLLRMACREPEATYEEIPLASWELAVRFPQLLGLETWLDPAFPDEEDPIRAAAESEHPYCAELLPELIAQVTQALALCRDSEAFAAQLRAHCGSAAPEVLAEVADLAFAHMAREHRNGTLVTPPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JTE5</accession>
    <name>A0A2M9JTE5_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Phosphoribosylglycinamide formyltransferase</fullName>
            <ecNumber evidence="3">2.1.2.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">5'-phosphoribosylglycinamide transformylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="3">GAR transformylase</fullName>
            <shortName evidence="3">GART</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">purN</name>
        <name evidence="6" type="ORF">CG723_19770</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CB01635</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the transfer of a formyl group from 10-formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>(6S)-10-formyltetrahydrofolate + N(1)-(5-phospho-beta-D-ribosyl)glycinamide = (6S)-5,6,7,8-tetrahydrofolate + H(+) + N(2)-formyl-N(1)-(5-phospho-beta-D-ribosyl)glycinamide</text>
            <dbReference type="Rhea" id="RHEA:15053"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="ChEBI" id="CHEBI:57454"/>
            <dbReference type="ChEBI" id="CHEBI:143788"/>
            <dbReference type="ChEBI" id="CHEBI:147286"/>
            <dbReference type="EC" id="2.1.2.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 3">Purine metabolism; IMP biosynthesis via de novo pathway; N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide from N(1)-(5-phospho-D-ribosyl)glycinamide (10-formyl THF route): step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the GART family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.2.2" evidence="3"/>
    <dbReference type="EMBL" id="NNBL01000006">
        <property type="protein sequence ID" value="PJN10144.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN10144">
        <property type="protein sequence ID" value="PJN10144"/>
        <property type="gene ID" value="CG723_19770"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00126"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004644">
        <property type="term" value="F:phosphoribosylglycinamide formyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd08645">
        <property type="entry name" value="FMT_core_GART"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01930">
        <property type="entry name" value="PurN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002376">
        <property type="entry name" value="Formyl_transf_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036477">
        <property type="entry name" value="Formyl_transf_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004607">
        <property type="entry name" value="GART"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001555">
        <property type="entry name" value="GART_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00551">
        <property type="entry name" value="Formyl_trans_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53328">
        <property type="entry name" value="SSF53328"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00639">
        <property type="entry name" value="PurN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00373">
        <property type="entry name" value="GART"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3 6" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014670480" description="Phosphoribosylglycinamide formyltransferase" evidence="4">
        <location>
            <begin position="42"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="domain" description="Formyl_trans_N" evidence="5">
        <location>
            <begin position="20"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="region of interest" description="5'-phosphoribosylglycinamide binding" evidence="3">
        <location>
            <begin position="30"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="10-formyltetrahydrofolate binding" evidence="3">
        <location>
            <begin position="111"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="3">
        <location>
            <position position="130"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="86"/>
        </location>
        <ligand>
            <name>(6S)-10-formyltetrahydrofolate</name>
            <dbReference type="ChEBI" id="CHEBI:57454"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="128"/>
        </location>
        <ligand>
            <name>(6S)-10-formyltetrahydrofolate</name>
            <dbReference type="ChEBI" id="CHEBI:57454"/>
        </ligand>
    </feature>
    <feature type="site" description="Raises pKa of active site His" evidence="3">
        <location>
            <position position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PJN10144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="221" mass="23604" checksum="09FA920461207508" modified="2018-04-25" version="1">MKPLCDPTNALPRKALAVAKRLVVLVSGSGTNLQALLDALAAEGAEGYGAEIVAVGADRDSIAGLERAERAGLPTFVCRVKDFATREEWDRALAEATAAYEPDLVVSAGFMKIVGKEFLARFGGRFVNTHPALLPSFPGAHGVRDALAYGAKVTGCTVHFVDDGVDTGPIIAQGVVEVRDEDDASALHERIKEVERRLLVDVVGRLARNGYRIEGRKVVIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JU14</accession>
    <name>A0A2M9JU14_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CG723_18215</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000005">
        <property type="protein sequence ID" value="PJN10318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN10318">
        <property type="protein sequence ID" value="PJN10318"/>
        <property type="gene ID" value="CG723_18215"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046200">
        <property type="entry name" value="DUF6233"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19746">
        <property type="entry name" value="DUF6233"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PJN10318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="110" mass="12373" checksum="FACB5590C6DF2DAA" modified="2018-04-25" version="1">MSELPPDLPRLRTLETWLVLSLDRVRRKIAEAERQEAEKQRGERDRPLAPDWLIEMGLGGRAPVYVHVGGCHMAGKRSRGVTDDQARRALWEQVPACPHCNPDGVLGVLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JU32</accession>
    <name>A0A2M9JU32_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Molybdenum transport system permease</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">modB</name>
        <name evidence="10" type="ORF">CG723_18605</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CB01635</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Part of the binding-protein-dependent transport system for molybdenum; probably responsible for the translocation of the substrate across the membrane.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cell membrane</location>
            <topology evidence="7">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000005">
        <property type="protein sequence ID" value="PJN10379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN10379">
        <property type="protein sequence ID" value="PJN10379"/>
        <property type="gene ID" value="CG723_18605"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015098">
        <property type="term" value="F:molybdate ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011867">
        <property type="entry name" value="ModB_ABC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006469">
        <property type="entry name" value="NifC_ABC_porter"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01581">
        <property type="entry name" value="Mo_ABC_porter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02141">
        <property type="entry name" value="modB_ABC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 8" id="KW-0500">Molybdenum</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="37"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="82"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="120"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="161"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="211"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="265"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="9">
        <location>
            <begin position="82"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU365097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PJN10379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="293" mass="30637" checksum="5359B2C7E79C4C26" modified="2018-04-25" version="1">MTELDKSGAAAEVLRGGDTRGAGPRRRRARTGARGRGVPLPLLLPALVGLAFLLLPLIALLVRAPWRSLPDQLTSPEVWQALQLSLICATAATAVSLVLGVPLAWLLARTEFPGRGFVRALVTLPLVLPPVVGGVALLLALGRNGVVGQLLDSWFGITLPFTTAGVVVAESFVAMPFLVISVEGTLRAADPRFEEAATTLGASRFTAFRRVTLPLIMPGIAAGAVLAWARALGEFGATITFAGNFPGRTQTMPLAVYLALQNDPAAAIALSLVLLAVSIAVLAGLRDRWMTAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JU91</accession>
    <name>A0A2M9JU91_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Sugar-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_18695</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000005">
        <property type="protein sequence ID" value="PJN10392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN10392">
        <property type="protein sequence ID" value="PJN10392"/>
        <property type="gene ID" value="CG723_18695"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006059">
        <property type="entry name" value="SBP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01547">
        <property type="entry name" value="SBP_bac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014689687" evidence="1">
        <location>
            <begin position="35"/>
            <end position="436"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN10392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="436" mass="46333" checksum="0FB1B7EAA73B425A" modified="2018-04-25" version="1">MKTPARISRAVAGGVALALGLTLSACGGGSSDSAGGGDSDKIHVLVYGDAANKVEKQLVATFNKTSKVKAVLDTIPGADYQQKLQTIISTPQAPDIFFNWGGGSIKPFVDADLLLPLDDFIKKDPALKSSFLPSVFDSAKVNGKPYGVPMRGTQPVLLFNNKKVLADAGVTPPKTWDDLLGAVKALKAKGVTPIALGGGDQWPTLMWFEYLYDRVAGPDVFQKALGGDKSAWESAGSKKALGMIRQLVDAGAFGTNYDSVKFTDQGSPTLLATGKAGFELMGSWEYSTQQDSHPAFAKKDLGYTSFPTVAGGSGDDANLVGNTNNFYSVMKKTKHPEAVAEFLKLQYSDEFVKAQLGIGNLPTTTNTEKFLGASASPDYSKYQLDLVKKAPSFQLSWDQAYPQSASTPMHQAVQQFVNGGLDTDGFIKAMQALPTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JUA7</accession>
    <name>A0A2M9JUA7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">N-acetylmuramoyl-L-alanine amidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CG723_19145</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000005">
        <property type="protein sequence ID" value="PJN10470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN10470">
        <property type="protein sequence ID" value="PJN10470"/>
        <property type="gene ID" value="CG723_19145"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008745">
        <property type="term" value="F:N-acetylmuramoyl-L-alanine amidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009253">
        <property type="term" value="P:peptidoglycan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06583">
        <property type="entry name" value="PGRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.80.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036505">
        <property type="entry name" value="Amidase/PGRP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002502">
        <property type="entry name" value="Amidase_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01510">
        <property type="entry name" value="Amidase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00644">
        <property type="entry name" value="Ami_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55846">
        <property type="entry name" value="SSF55846"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014696115" evidence="2">
        <location>
            <begin position="47"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="domain" description="N-acetylmuramoyl-L-alanine amidase" evidence="3">
        <location>
            <begin position="288"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="107"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00644"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PJN10470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="661" mass="70878" checksum="A517180464C93246" modified="2018-04-25" version="1">MPSTTSDHSPAARRRTNQAARAAGTLATAALLLPLLGAAPPSEARGASDAGLQHAFATAAAEYRVPQSVLLGVSYLQSRWDTHGGAPSVTGGYGPMHLTDARAALAGVAAHSEAEGDPRGDTSRPALTPKTKVPRNSQLPARLKSLTRAAELSGIPAEQLRSDPAANVRGGAALLAASQKALGKPLSSDPADWYGAIAKFSGADDTATAATYANDVFAVIHDGERRTTDAGQHVELAADRSLKPDAAQVRSMGLRKSDESGTECPATVSCEWIPAPYEEFGDGDYGNHDLADRPNDQSIDYIVIHDTEATWDTTLQLVQDKTYLAWHYSLRSTDGHIAQHVKAKDVGWHAGNWYVNAKSLGLEHEGFLAQPDSWYTEEMYRASSRLVKYLAKKYDIPLDRQHILGHDNVPGTTPAGIKTMHTDPGPYWDWAHYFALMGKPFKATAGTKGGLVTIAPDFARNKPVYTGCVKAGETCAAHGSGAVRVYTAPSEDAPLIKDIGLRPGGEDSTTDVNDMGARLSTGQQYAVAERKGDWTAVWYLGQKAWFKNPKKQPTAVNAAGLVVAPKAGRTDVPVYGRAYPEKEAYPADITPQAISPLPYKLLAGQRYVAGGRTTGEYFFSPTFDTTSHRVVRGKDVYYEIQFGHRVAYVRAADVQVLPSGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JUT6</accession>
    <name>A0A2M9JUT6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_15660</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000004">
        <property type="protein sequence ID" value="PJN10645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN10645">
        <property type="protein sequence ID" value="PJN10645"/>
        <property type="gene ID" value="CG723_15660"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004104">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02894">
        <property type="entry name" value="GFO_IDH_MocA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GFO_IDH_MocA" evidence="1">
        <location>
            <begin position="13"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="domain" description="GFO_IDH_MocA_C" evidence="2">
        <location>
            <begin position="147"/>
            <end position="365"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN10645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="365" mass="38290" checksum="609760BA34DAE261" modified="2018-04-25" version="1">MTSGTAGATGSPLRVGLVGYGLAGSVFHAPLIAATDGLVLDTVVTSNAERQAQARASFGDGIRFVATPDELWPLADELDLIVIASPNKTHVPIATAALKAGLPVVVDKPIAGTAAEARELAALAEERGLLLSVFQNRRWDNDFLTLRSLIADGELGDVWRFESRFERWRPQPKGGWRESGDPEEIGGLLYDLGSHVVDQALVLFGPAVSVYAESDVRRAGAAADDDTFIAITHANGVRSHLYVSATAAQLGPRFRVLGSLAGYVKYGLDPQEAVLREGTIPAAGEPWGVEPESMWGRIGSGESPLTGGGRPVETLPGAYPAYYAAVAAALRGSGENPVTAEQAASALDVLEAARRSARDGVTVTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JUV6</accession>
    <name>A0A2M9JUV6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">2-aminoethylphosphonate ABC transporter permease subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CG723_15685</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CB01635</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000004">
        <property type="protein sequence ID" value="PJN10650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN10650">
        <property type="protein sequence ID" value="PJN10650"/>
        <property type="gene ID" value="CG723_15685"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033223">
        <property type="term" value="P:2-aminoethylphosphonate transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017636">
        <property type="entry name" value="AminoethylPonate_ABC_perm-PhnU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03226">
        <property type="entry name" value="PhnU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="23"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="78"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="116"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="156"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="213"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="260"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="74"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PJN10650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="290" mass="30362" checksum="D3F224BC1B761B20" modified="2018-04-25" version="1">MASATLSTPVSKATKPRKGTPKWVWALPPVAVLALVFLYPLALVVQQSVQPDTGGTSLEPYADVFASSAFREALGTTVWLAVGATVGCLVLGFALALVIAFVPFPGGKAVAKFIDVFLSFPSFLITLALLFVYGSVGMANGLWTDVTGAASGPFQFLTTPWGVLLAEITYFTPFVMRPLLAAFSQIETAQLEVASSLGAKPARIVRQVILPEALPALAAGGSLVLVMCLNEFGIVLFTGAKGVTTLPMLVYSKAILESDYPGACVVAVVNVLISVGLYGLYRVVSRRAGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JVH5</accession>
    <name>A0A2M9JVH5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Dihydrodipicolinate synthase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_17220</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the DapA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000004">
        <property type="protein sequence ID" value="PJN10901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN10901">
        <property type="protein sequence ID" value="PJN10901"/>
        <property type="gene ID" value="CG723_17220"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002220">
        <property type="entry name" value="DapA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020625">
        <property type="entry name" value="Schiff_base-form_aldolases_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12128">
        <property type="entry name" value="PTHR12128"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00701">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001365">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00146">
        <property type="entry name" value="DHPICSNTHASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01130">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00666">
        <property type="entry name" value="DHDPS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0704">Schiff base</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRNR" id="PIRNR001365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN10901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="311" mass="32217" checksum="C40AF0B9F564B36C" modified="2018-04-25" version="1">MTSPTPLTGVVPPVCTPLTPDNEVDVASLVRLVDHLVAGGVDGLFVLGSTSEAAFLPDRHRKVVIDTVVGHVAGQLPVLAGAIDMATLRVLDHARTAAEAGADGIVATAPFYTRTHPAEIARHFRLLAQRCGRPVFAYDLPASVHSKLGADLVLDLAADGTLAGLKDSSGDEGAFREVLIGARSRADITGFSVLTGSELTVDSALAMGADGVVPGLGNVDPAGYARLYAYCRAGDRERARIEQERLCALFQMVRVGDPARMGGSSSALGAFKAALYLRGVIDCPVTAAPQIPLSAGEVERVGKFLAGAGLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JVL7</accession>
    <name>A0A2M9JVL7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ABC transporter substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_17240</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000004">
        <property type="protein sequence ID" value="PJN10904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN10904">
        <property type="protein sequence ID" value="PJN10904"/>
        <property type="gene ID" value="CG723_17240"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042597">
        <property type="term" value="C:periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030678">
        <property type="entry name" value="Peptide/Ni-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039424">
        <property type="entry name" value="SBP_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000914">
        <property type="entry name" value="SBP_5_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019546">
        <property type="entry name" value="TAT_signal_bac_arc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30290">
        <property type="entry name" value="PTHR30290"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00496">
        <property type="entry name" value="SBP_bac_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002741">
        <property type="entry name" value="MppA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01409">
        <property type="entry name" value="TAT_signal_seq"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SBP_bac_5" evidence="1">
        <location>
            <begin position="95"/>
            <end position="449"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN10904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="540" mass="58444" checksum="B5BFF5135FDA9677" modified="2018-04-25" version="1">MSDHEPTGRRSFLKYTGALGAAAAISTSLSACSSGPKSTNDTGGGKGGGSSLTAVIGYGNDGSWDPTQTASAFAMAGNQHIYEGLLDTDPITREPYAALATRVPTDAELATTSWKFTLRAGAKWHDGKPVTADDVVFVFDRILDPGTQSLAKGFFESWLKEVRKTGDDSVELVLKFPFPDGAARLTLAKIMPKHVFSKPGAWDDATKGKAVGSGPYRQTSHQPKTNTTFEAYPDYNGPLKASFKKMNWLTIVDAAPRVAKISGGSADAQIADNIPYANIAQLKKGGLTVEGGAGMNNLFLMFNTAHKPFDDVRVRQALHYAIDKQKMIEVALKGHGKGASSFLNEGNPDHRPAKTVYDYDPEKAKKLLKDAGVSGLSVSLMSVNVSWIMDCLPTIKASWDAIGVKTTLDPQETTAVFTKMDQKKDYQIVAAASNPNQFGLDADLIMHYNYGPSNLWMGYARWAGSSDAKHLFKLMDQATREPDPAKKKTMIQEYIDIVAEQAVLYPVVHNELMTAWDPKKITGVQAQPYPGINVLKAKPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JWI6</accession>
    <name>A0A2M9JWI6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NADPH:quinone reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_09760</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN11219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN11219">
        <property type="protein sequence ID" value="PJN11219"/>
        <property type="gene ID" value="CG723_09760"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019475">
        <property type="term" value="P:L-lysine catabolic process to acetate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008567">
        <property type="entry name" value="KCE_family"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37418">
        <property type="entry name" value="PTHR37418"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05853">
        <property type="entry name" value="BKACE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="287"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN11219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="306" mass="32727" checksum="285C0F6C9192BA57" modified="2018-04-25" version="1">MPMNQDVIITCALTGAGDTVRKSPHVPVTPEQIARSAVEAADAGAAEVHIHVRDPETGAPSRDPRLYREVVERIKETGTDVVINLTAGMGGDLVIDPDEPLKQLPGTDLVGGLERLPHVEDLLPDICTLDCGSLNFGDGSNLYVSTPDMLRAGARRIQELGVRPELEIFDTGHLWFAKQLLAEGLLDDPTVFQLCMGIPWGAPADPGVLQSMVNMLPEGAQWASFALGRMQMPWVAQSVVLGGHVRVGLEDNLYLGKGVKATNAQLVERAVTIVEAMGARVATPDEARQKLGLKPRTPSVAQEGTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JWV0</accession>
    <name>A0A2M9JWV0_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">HTH gntR-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CG723_10565</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN11360.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN11360">
        <property type="protein sequence ID" value="PJN11360"/>
        <property type="gene ID" value="CG723_10565"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07377">
        <property type="entry name" value="WHTH_GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.530">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011711">
        <property type="entry name" value="GntR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008920">
        <property type="entry name" value="TF_FadR/GntR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07729">
        <property type="entry name" value="FCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
        <property type="entry name" value="GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00035">
        <property type="entry name" value="HTHGNTR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00895">
        <property type="entry name" value="FCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00345">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48008">
        <property type="entry name" value="SSF48008"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50949">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH gntR-type" evidence="4">
        <location>
            <begin position="6"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PJN11360.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="232" mass="24759" checksum="63E84CED13A206D7" modified="2018-04-25" version="1">MAVRRTTLFDQVAGEIVDLIEESGLKPGDDVPSEGELAARFGVNRLAVREAIRVLSAREILVSSQGRPARVNVPSARVFGQILQFRLRQQSLEVADVLDARAAIEGALASRAAARVASGDASPDAAGALLDEMEDAVEDRDRFVALDLAFHHEIARMAGNGMLELVLESLSDILTAHRLASYEGRSRRGDSQRATITAHRRILAAIATGAQDDAVAAMAAHLDETGEDLAVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-05-25" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JWV2</accession>
    <name>A0A2M9JWV2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">LacI family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CG723_10685</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN11381.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN11381">
        <property type="protein sequence ID" value="PJN11381"/>
        <property type="gene ID" value="CG723_10685"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01392">
        <property type="entry name" value="HTH_LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000843">
        <property type="entry name" value="HTH_LacI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046335">
        <property type="entry name" value="LacI/GalR-like_sensor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00356">
        <property type="entry name" value="LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13377">
        <property type="entry name" value="Peripla_BP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00354">
        <property type="entry name" value="HTH_LACI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50932">
        <property type="entry name" value="HTH_LACI_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH lacI-type" evidence="4">
        <location>
            <begin position="5"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PJN11381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="340" mass="35719" checksum="7055247B73B71163" modified="2018-04-25" version="1">MAQSVGIKDVARAAGVSVGTVSNVINRPDSVASDTRARVLSAIDRLGYVRSESARQLRAGRSRIMGLLVLDMGNPFFVDVARGAERAARDAGLGVMVCNSAQNPSEEAEYLSLFAEQRVRGVLLTPAEASGRNIESFRRHGIPFVLVDRVAEGTSECSVSVDDVTGGALAVRHLVDAGHRSIAYVSGPPALNQVKDRRTGALQALAEAGLPAGALRELPTERLDVGAGRDAGARLLGLADRPTAAFCANDLLALGVLQAMYAAGVRVPEDIAIVGYDDIEFASAATVPLTSVRQPAVTMGAMAAELLLEETEPASGEPHRHRRVVLQPELVVRGSSLGSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JXG2</accession>
    <name>A0A2M9JXG2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CG723_11030</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN11437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN11437">
        <property type="protein sequence ID" value="PJN11437"/>
        <property type="gene ID" value="CG723_11030"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="15"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="48"/>
            <end position="55"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PJN11437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="249" mass="27060" checksum="52058D073ADD6471" modified="2018-04-25" version="1">MSPTSAAPLRQGAELALDDVLLGHREGRPLPGHVRLRIAPGELVAVLGPSGCGKSTLLRTLAGLLPPLDGQVTQDGAPIRGPEADRALIFQEDALLPWRSVQANVELPLAIRRLGREERRRVATEWLERVGLDGHARKLPHRLSGGQRQRVQLARALAGRPRAVLMDEPFGALDPHTRAGMQDLFVDILRGTGATVVFVTHDVDEALYLGDRIALLSSGEVLDVPHPRQRDARNAPATTGLRRRILTSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JXL5</accession>
    <name>A0A2M9JXL5_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Glyco_hydro_114 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_11855</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN11578.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN11578">
        <property type="protein sequence ID" value="PJN11578"/>
        <property type="gene ID" value="CG723_11855"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004352">
        <property type="entry name" value="GH114_TIM-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03537">
        <property type="entry name" value="Glyco_hydro_114"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014696119" description="Glyco_hydro_114 domain-containing protein" evidence="1">
        <location>
            <begin position="33"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_hydro_114" evidence="2">
        <location>
            <begin position="50"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03537"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN11578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="275" mass="30093" checksum="0E68D0919A2AF1BC" modified="2018-04-25" version="1">MMEYGMASRTNVLIHVLVATLLFPLAVGCSSGDAKSEGPDWSPPPRHAGFDYQIGGAYPPAKGVGVVSRDRAARPARGVYNMCYVNAFQAQPDERDDWPADLLLRDRNGRVVIDQDWDEPLLDIGTPNKRERVAARVGPWIDGCADHGFDAVEPDNYDSYTRSKGRLSARDAKAFMSLLVRRAHRAGLAVGQKNTAELAPDGHQLGVDFAVAEECGAYDECGVYAKAFDDRVVVIEYTDTGLRKACSAFGTRLDIVRRDHDVTTPGGNGYVRRTC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JY85</accession>
    <name>A0A2M9JY85_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Formate dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CG723_13385</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CB01635</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mo-bis(molybdopterin guanine dinucleotide)</name>
            <dbReference type="ChEBI" id="CHEBI:60539"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the prokaryotic molybdopterin-containing oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN11829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN11829">
        <property type="protein sequence ID" value="PJN11829"/>
        <property type="gene ID" value="CG723_13385"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008863">
        <property type="term" value="F:formate dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030151">
        <property type="term" value="F:molybdenum ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043546">
        <property type="term" value="F:molybdopterin cofactor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02787">
        <property type="entry name" value="MopB_CT_ydeP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02767">
        <property type="entry name" value="MopB_ydeP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009010">
        <property type="entry name" value="Asp_de-COase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037951">
        <property type="entry name" value="MopB_CT_YdeP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006657">
        <property type="entry name" value="MoPterin_dinucl-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006656">
        <property type="entry name" value="Mopterin_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010046">
        <property type="entry name" value="Mopterin_OxRdtse_a_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041953">
        <property type="entry name" value="YdeP_MopB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43105:SF4">
        <property type="entry name" value="PTHR43105:SF4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00384">
        <property type="entry name" value="Molybdopterin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01568">
        <property type="entry name" value="Molydop_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50692">
        <property type="entry name" value="SSF50692"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01701">
        <property type="entry name" value="Fdhalpha-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Molybdopterin" evidence="6">
        <location>
            <begin position="136"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="domain" description="Molydop_binding" evidence="7">
        <location>
            <begin position="662"/>
            <end position="763"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PJN11829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="777" mass="86438" checksum="5755BFCD6AFB69C1" modified="2018-04-25" version="1">MVEGLSVLSIDSEAPEELEPSVGPIPKEDPEYHPYHHPAAGWGAAKSVTQFLVRERELVDGPRAIMKMNHENTGFDCPGCAWPDDTKGLKLDICENGIKHVTWEMTRKRVERDFFAAHTVTELFEWSDFKLEDQGRLTEPMVYNPDTDHYVPISWKDAFELVGSTLRGLENPNQASYYTSGRLGNEATFLYQLMARELGTNNLPDCSNMCHEASGRAMQASLGTGKGTVDLKDWESADALFIMGVNAASNAPRMLTALAEAYHRGAQIVHVNPLVEAAATRTIVPHDFMDMALFKTTKTSTLNLQVRIGGDLALLRGMAKAVIEESKLDPKALDQEFIDRHTTGFDSYRQLCESTSWEELERQSGVSRDDILKAARVYCDADRSIISWCLGLTQHEHGVDTVREIINLLLLRGNLGREGAGPSPVRGHSNVQGNRTCGIDHRPDDEFLDRLAEYCKIDPPREHGLDTIGTIQAMRRGDVKVFVGMGGNFALAAPDSPITYEALRNCDLTVQVSTKLNRSHLVHGRQALILPCLGRTEKDHQRKGIQSTSVEDSMSMVHMSVGMKRPASPHLLSEPAIVAGMARAALPASSTPWEWYIEDYDRIRDTMSQALDGFEDFNRRVRLPLGFRLKQPARELVFLTPSGGAEFSDAALPDVVPAPGTLALGTMRSHDQWNTTIYSDNDRYRGIKNLRELVFMNEDDMRERGISEFDPVDITSTARDGSHRYLNGYLAIPYDIPRGCAAGYMPEMNVLCALVDYSTQSDQPIMKHVKVTIEAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JYI7</accession>
    <name>A0A2M9JYI7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Sugar ABC transporter substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_14055</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN11939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN11939">
        <property type="protein sequence ID" value="PJN11939"/>
        <property type="gene ID" value="CG723_14055"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006059">
        <property type="entry name" value="SBP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01547">
        <property type="entry name" value="SBP_bac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014993653" evidence="1">
        <location>
            <begin position="33"/>
            <end position="447"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN11939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="447" mass="48298" checksum="384F89C5C07B9254" modified="2018-04-25" version="1">MPGRQSRRSVLAAITALPLTGALSACSGNDSASSGSSSKTGTKSKTTITFWSALRGSQEVVDAFNKTHDTIQVAFEQIPSGTSGGYLKLSNAARAGNAPDVATIEYPQVPGYAIDGVARDITDVISDKLKAKLLPQALGLTTFEGRTYSVPLDVEPMVLHYRKDLFDKYGFDVPTTWDEYTDLARAVRRTGGKRKVTFFSTDMGQFSGWCWGAGAHWFDTSKGAWNVSLADAPTRRVSQYWQRLIDEDLVYVNPPNSREADAQVGNGLVLTRHSGAWDAGAQMNARPQQKGLWRIAPQPQWDPAKPALGTQGGSTFAITKDSRHPEAAMEFIAWQVSSPDAIKARLSSGASSQYPAATELIKEGRAAFDRSYYGGQDIYTLFENEAQKISDGWVWGPRMTATGQVMSDAFARAAAGSGTIESSMRAAQDGTMPDLKALGLKTTQHST</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-05-25" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JYK8</accession>
    <name>A0A2M9JYK8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CG723_14175</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN11959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN11959">
        <property type="protein sequence ID" value="PJN11959"/>
        <property type="gene ID" value="CG723_14175"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01392">
        <property type="entry name" value="HTH_LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000843">
        <property type="entry name" value="HTH_LacI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046335">
        <property type="entry name" value="LacI/GalR-like_sensor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00356">
        <property type="entry name" value="LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13377">
        <property type="entry name" value="Peripla_BP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00354">
        <property type="entry name" value="HTH_LACI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50932">
        <property type="entry name" value="HTH_LACI_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH lacI-type" evidence="4">
        <location>
            <begin position="2"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="domain" description="HTH cro/C1-type" evidence="5">
        <location>
            <begin position="3"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PJN11959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="348" mass="36530" checksum="B3F008993AA54921" modified="2018-04-25" version="1">MATIKDVAERAGVAPSTVSYVLSGSRKISEDTRRAVQAAIAELGYHPRASARTLRSARSDVLAMAVPRVPGAYRAVDGRFAIDISDAARSHGYDLLLMTDRDGVGGLRRVAGSGLADAAVLMAVEEQDPRIGAMRELGFPTALLGRGDDDSALPWVDLDWEAAVALALRETAAAGHRHIIFLASADHEIAARRGYAVHGLDGARRAAKETGADIRVHPSSSDPDVLRRRVRDVLGARPAPTALVVQHLHRLPDLLAEVAATGLRVPEDLAVVPVGTLPDDLGGRLLPRIELPVAEMSLAVVELAVRAIAAARPGSGTQAHPAPGLAPHRLIAPQMAPGLTIAPPKGHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JZ74</accession>
    <name>A0A2M9JZ74_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_11795</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN12166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN12166">
        <property type="protein sequence ID" value="PJN12166"/>
        <property type="gene ID" value="CG723_11795"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="SSF88713"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="54"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN12166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="420" mass="45875" checksum="7EF8CBCD0233532C" modified="2018-04-25" version="1">MSEISRRGAVGLGLGIGLGAAAAGLAGCGMGNDTARPPAGRGLLGGKAAPRLIGDGSTAYTGKQPNQPESPVPLEPGQTPPQFVIFSWDGAGEVGKGLFPRFLELAETHGARMTFFLSGLYLLPESKKRLYDPPNNPVGASDVGYLTDEHLKETLKYTRQAWLDGHEIGTHFNGHFCAGSGSVANWTPAQWYSEIEQASLFIKTWRTNTGWHDQDPLPFDYDKELIGGRTPCLLGQDNLLPTARELGWRYDASSPGGVQRWPEKRQGLWDLPLQAIPFPGHTFEVLSMDYNILANQSKNSTRGPSYNYAGWRQQAIESYLAGFKRAYETNRAPFFVGNHFEDWNGGIYMDAVETALKEIAGKKDVRLVSFRQFVDWLDAQDPNVLDRLRSLEVGEVPAGGWARYLADAVTAPTGAARGGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JZA6</accession>
    <name>A0A2M9JZA6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MarR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_13165</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000003">
        <property type="protein sequence ID" value="PJN12200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN12200">
        <property type="protein sequence ID" value="PJN12200"/>
        <property type="gene ID" value="CG723_13165"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000835">
        <property type="entry name" value="HTH_MarR-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023187">
        <property type="entry name" value="Tscrpt_reg_MarR-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01047">
        <property type="entry name" value="MarR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00347">
        <property type="entry name" value="HTH_MARR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01117">
        <property type="entry name" value="HTH_MARR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50995">
        <property type="entry name" value="HTH_MARR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH marR-type" evidence="1">
        <location>
            <begin position="27"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN12200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="190" mass="21186" checksum="78416A440374CDF9" modified="2018-04-25" version="1">MPGQRSITEAEKLAEAKLGGMPVRHEQMAVVANIYRAASAVRQHLENSVLRESDLTWTAFVVLWVIWVWGESETRHVAEEAGISKGTLTGVSRTLEARGLVRRAGHPNDGRLVLLSLTDEGEELMRRVFPKFNEEEAFVAGQLSDEECRSIADGLRRVVLQVEEHGEERRLALLDGAEPAPRRSGRRPKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JZF7</accession>
    <name>A0A2M9JZF7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Aminotransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_04075</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000002">
        <property type="protein sequence ID" value="PJN12250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN12250">
        <property type="protein sequence ID" value="PJN12250"/>
        <property type="gene ID" value="CG723_04075"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032856">
        <property type="entry name" value="GDE_N_bis"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14742">
        <property type="entry name" value="GDE_N_bis"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="SSF48208"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GDE_N_bis" evidence="2">
        <location>
            <begin position="10"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="51"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN12250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="663" mass="70159" checksum="813DD87D0C975877" modified="2018-04-25" version="1">MTDRQHQLLVRGATFAAIGPGGDISGVRGSGSPDGLFVRDGRHLSRWQLTADGAAPEVLTPAGRPGGDAGGRTGGDAAGRTGAGEGVARCVLVPRGGRLEPPAYTLFREQAVADGAFVETLRVVSNRAVPTTVQLALTVDADFTDQFELRADHRTYAKTGAVRSRSVLEDGVRFGYRRGEWRSSTTVTAEPAPDAVEETGTGARRLVWSLELTGHGTADLNLRVAARPHGAPRTPVPASPADAAAELAARTEEFTRDVTLPAAWPGLAAACTRGLADLAVLQVPATGPDGERLSVPGAGVPWFLTLLGRDALLTSLFALPYRPGLAAATLPVLAATQATESTEGAVAQPGKIVHEVRHGELAHFGQVPFARYYGSVDATPLFLVLLGAYTDRTGDVATARRLEPHARAAVSWMLDHGGLTSRGYLVYRADRGGLANQNWKDSPGAICSADGSRPTGPVTAAGAQGYAYDALRRTAALARTAWDDPVYADLLEQTATDLRDRFQRDFWMADRAFPALALDGEGRHVDALASDAGHLLWSGLLDKEYGEVVGRRLLEPDFFSGWGVRTLAAGQAAYHPLSYHRGSVWPHDNALIALGLARYGLHDEARTVANALVEAAAASGHRLPEVLAGYARESYPAPVPYPHACERESRSAAAPLALLTAVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JZQ7</accession>
    <name>A0A2M9JZQ7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Molecular chaperone DnaJ</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_04795</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000002">
        <property type="protein sequence ID" value="PJN12372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN12372">
        <property type="protein sequence ID" value="PJN12372"/>
        <property type="gene ID" value="CG723_04795"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018961">
        <property type="entry name" value="DnaJ_homolog_subfam-C_membr-28"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09350">
        <property type="entry name" value="DUF1992"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF1992" evidence="1">
        <location>
            <begin position="14"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF09350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN12372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="137" mass="15438" checksum="3CE33350D7EE2D7C" modified="2018-04-25" version="1">MTERKPPDVSFESWVDKQIRDAERAGDFSHLAGAGKPLPSTADTTYDENWWIKQKMAREGFSVLPPSLALRKEAEDALAEAAQASSERIVRKIVTDINDKIRDMMFKPPPGPPLGLKPYDVEEIVRDWHERRGAHGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JZR4</accession>
    <name>A0A2M9JZR4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Antibiotic biosynthesis monooxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_04790</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000002">
        <property type="protein sequence ID" value="PJN12371.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN12371">
        <property type="protein sequence ID" value="PJN12371"/>
        <property type="gene ID" value="CG723_04790"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007138">
        <property type="entry name" value="ABM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03992">
        <property type="entry name" value="ABM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51725">
        <property type="entry name" value="ABM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABM" evidence="2">
        <location>
            <begin position="3"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="72"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN12371.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="104" mass="11668" checksum="0DB5BA75289A5D39" modified="2018-04-25" version="1">MSIVKINVLTVPAEQRETLEKRFASRAGAVENSDGFEWFELLRPIEGTDDYLVYTRWRDEASFTAWMEGSMKEAHQGGADRPKPAASGSQVWSFEVAQQASPKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JZS7</accession>
    <name>A0A2M9JZS7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ECF transporter S component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_04930</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000002">
        <property type="protein sequence ID" value="PJN12393.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN12393">
        <property type="protein sequence ID" value="PJN12393"/>
        <property type="gene ID" value="CG723_04930"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017196">
        <property type="entry name" value="ECF_substrate-spec_UCP037395"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024529">
        <property type="entry name" value="ECF_trnsprt_substrate-spec"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12822">
        <property type="entry name" value="ECF_trnsprt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037395">
        <property type="entry name" value="UCP037395_ABCper"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="24"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="57"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="82"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="122"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="179"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="240"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN12393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="281" mass="28849" checksum="3D0830E47C074772" modified="2018-04-25" version="1">MKTAPGTGRPDRQARAVRLGPRSVVALLLVSAVGVAAFGWPLLAGPSSQVSAHAQDAPWLFAGLLVLLVGVVAAAVSEGGVGPKAVAMLGVLAATGAALRPIGAGTAGIEPMFFLMVLSGRVLGPGFGFVLGSVTMFASALLTGGVGPWMPFQMLSMGWFTMGAGLLPGPDRLRGRAEVLMLAAYGFLAAFAYGTVMNLAGWPFLDSLSSSVAFQAGAPLHENLVRFLAYCLATSLGWDLGRAALTVVLTVTVGPALLRALRRATRRAAFEAPVTFEGTEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K009</accession>
    <name>A0A2M9K009_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Transport permease protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CG723_05350</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CB01635</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the ABC-2 integral membrane protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000002">
        <property type="protein sequence ID" value="PJN12465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN12465">
        <property type="protein sequence ID" value="PJN12465"/>
        <property type="gene ID" value="CG723_05350"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046677">
        <property type="term" value="P:response to antibiotic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC_2_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000412">
        <property type="entry name" value="ABC_2_transport"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01061">
        <property type="entry name" value="ABC2_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006648">
        <property type="entry name" value="DrrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51012">
        <property type="entry name" value="ABC_TM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0046">Antibiotic resistance</keyword>
    <keyword evidence="8" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="49"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="78"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="123"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="160"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="191"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="248"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="domain" description="ABC2_membrane" evidence="9">
        <location>
            <begin position="27"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PJN12465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="274" mass="29837" checksum="A8AA78194A697E38" modified="2018-04-25" version="1">MSATTLTPPLNLEADSRISLRSHIRHTGALVRRNLLWIRQDPESMFDAVLMPIVFTLLFVYVFGGSIGQALGGGQDQYVQYVVPGMMAMMSMNIAMAVGTGFNQDFQNGIMDRFRTLPIGQGSVLFAKIVVELMRLLIATTIMMIVGLLVGFDITNWPGLFAAVGLTALFGTSIMWIFLVLGVVMKSAQAVQGMGFLVLMPLQFGSSIFAPTQSMPGWLQAFTDYNPLSSLADSARGLMVGGPVAHDVWVTVIWSAVLTLVMAPIAIHKFRTKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K039</accession>
    <name>A0A2M9K039_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Alpha-sialidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_05325</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000002">
        <property type="protein sequence ID" value="PJN12460.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN12460">
        <property type="protein sequence ID" value="PJN12460"/>
        <property type="gene ID" value="CG723_05325"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004308">
        <property type="term" value="F:exo-alpha-sialidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011040">
        <property type="entry name" value="Sialidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026856">
        <property type="entry name" value="Sialidase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036278">
        <property type="entry name" value="Sialidase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10628">
        <property type="entry name" value="PTHR10628"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13088">
        <property type="entry name" value="BNR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50939">
        <property type="entry name" value="SSF50939"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sialidase" evidence="2">
        <location>
            <begin position="59"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN12460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="388" mass="41427" checksum="7BD03728755994E6" modified="2018-04-25" version="1">MPAHTASTVNSSGRVHREFPRGGEGWGVLTETSVPFRAGREGYASFRIPAAVTTRSGVLLAFCEGRVGSRVDYGNIDVVLKRSTDGGRTWDPLQVVAANGNDLAGNPAPVVLDTGRVLIVHVRNAAGATETAIRRGEVAPEDGRRVWVQHSDDEGLTWSSPREITAQAKNGNWRWYATGPGHAIQTHSGRVVVPANHSLPPAGGDTGTEGKYDGGHCLLSDDRGRTWRLGYVDDHPDGYVNVNETTAVELPDGRLYFNARNDSPAPGTRADATSEDGGESLVKAFRPQAGLVGPVVEGSLLRLGEVLLFAGPADPGFRALMSVRASEDEGVTWRVVHTVDGLPAAYSDLVQADPETVGLLYETGDFSAYETITFRRIPVAALLGRTPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-09-29" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K048</accession>
    <name>A0A2M9K048_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Arsenate reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_05620</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the ArsC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000002">
        <property type="protein sequence ID" value="PJN12512.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN12512">
        <property type="protein sequence ID" value="PJN12512"/>
        <property type="gene ID" value="CG723_05620"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008794">
        <property type="term" value="F:arsenate reductase (glutaredoxin) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03034">
        <property type="entry name" value="ArsC_ArsC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006659">
        <property type="entry name" value="Arsenate_reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006660">
        <property type="entry name" value="Arsenate_reductase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30041">
        <property type="entry name" value="PTHR30041"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03960">
        <property type="entry name" value="ArsC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51353">
        <property type="entry name" value="ARSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN12512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="120" mass="13395" checksum="A77F48138BF7D6FC" modified="2018-04-25" version="1">MEIWINPACSKCRSALSLLDAEGADYTVRRYLEDVPSEDDIRAVLERLGLEPWDITRTQEADAKELGLKDWARDAGARDRWIAALSAHPKLIQRPIITAEDGTAVVARSEDAVRDALGRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K057</accession>
    <name>A0A2M9K057_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Flotillin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CG723_04955</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CB01635</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the band 7/mec-2 family. Flotillin subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000002">
        <property type="protein sequence ID" value="PJN12397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN12397">
        <property type="protein sequence ID" value="PJN12397"/>
        <property type="gene ID" value="CG723_04955"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.479.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001107">
        <property type="entry name" value="Band_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036013">
        <property type="entry name" value="Band_7/SPFH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027705">
        <property type="entry name" value="Flotillin_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13806">
        <property type="entry name" value="PTHR13806"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01145">
        <property type="entry name" value="Band_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00244">
        <property type="entry name" value="PHB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117892">
        <property type="entry name" value="SSF117892"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PHB" evidence="4">
        <location>
            <begin position="2"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="375"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="387"/>
            <end position="401"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PJN12397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="401" mass="42593" checksum="A46F2F7A380F569C" modified="2018-04-25" version="1">MFGYRVPAPDEAMLISGGRRGLGGAPFRVVTGHGKFVLPIFRKTRFLSLAMSEAEVVEKCVTRQGIALTVRAVIAFKVGNDTESIVNAGQRFLSDQDQMSVLTGRIFAGHLRSIIGSMTVEEIVTERQKLAAEVLDTSKAEMAKIGLIVDSLQIQSIDDGNTGYIDAMSAPHKAAIQRQAQIAQAQATQASTQAEQEAQRNQAEYARQTAVVQAEYKAEVDRAQAAAAQAGPLAQAHAEQEVLAARTELAERAAELRQQQLVAEVVKPAEADAERIRVMAIAEAERMKIQAAAAASYDRVALDRMLIDQLPQIVKEAAGGLKGANVNVLNGADGLGEIAAGLVGQGLTILDSVRRNLGGPDGDAKKSGGEMEIQRYLGAASSPVDGRDGRDSGDDGPVDIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K077</accession>
    <name>A0A2M9K077_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">RDD family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CG723_05655</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CB01635</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000002">
        <property type="protein sequence ID" value="PJN12518.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN12518">
        <property type="protein sequence ID" value="PJN12518"/>
        <property type="gene ID" value="CG723_05655"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010432">
        <property type="entry name" value="RDD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016795">
        <property type="entry name" value="UCP021697"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06271">
        <property type="entry name" value="RDD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF021697">
        <property type="entry name" value="UCP021697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="49"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="78"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="118"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="domain" description="RDD" evidence="6">
        <location>
            <begin position="43"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF06271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PJN12518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="156" mass="16635" checksum="D35600BF4D0003E6" modified="2018-04-25" version="1">MDNRQAIGSWLSGPRAAAEDAGVEFGYRGEQLGLPEQGPGSIARPGRRMAALAIDWALCMLIAYGLLTHGYNQATGNWALGIFFVLGLLTVGTVGFTPGKRIMGLRVVAQDGSGRLGLGRVLVRTLLLCVAVPALIWDRDGRGLHDRLARAVQVRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K0N4</accession>
    <name>A0A2M9K0N4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Acetyl-CoA acetyltransferase</fullName>
            <ecNumber evidence="6">2.3.1.9</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CG723_06640</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CB01635</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the thiolase-like superfamily. Thiolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.9" evidence="6"/>
    <dbReference type="EMBL" id="NNBL01000002">
        <property type="protein sequence ID" value="PJN12695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN12695">
        <property type="protein sequence ID" value="PJN12695"/>
        <property type="gene ID" value="CG723_06640"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003985">
        <property type="term" value="F:acetyl-CoA C-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd00751">
        <property type="entry name" value="thiolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002155">
        <property type="entry name" value="Thiolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020617">
        <property type="entry name" value="Thiolase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020613">
        <property type="entry name" value="Thiolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020616">
        <property type="entry name" value="Thiolase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02803">
        <property type="entry name" value="Thiolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00108">
        <property type="entry name" value="Thiolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000429">
        <property type="entry name" value="Ac-CoA_Ac_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01930">
        <property type="entry name" value="AcCoA-C-Actrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00737">
        <property type="entry name" value="THIOLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Thiolase_N" evidence="4">
        <location>
            <begin position="5"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="domain" description="Thiolase_C" evidence="5">
        <location>
            <begin position="263"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-thioester intermediate" evidence="2">
        <location>
            <position position="89"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="2">
        <location>
            <position position="341"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="2">
        <location>
            <position position="371"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000429-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PJN12695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="385" mass="40801" checksum="2A8045369BDD5811" modified="2018-04-25" version="1">MAEAYIVEAVRTPVGRRKGGLAAAHPADLGAHVLKELVARCGIDPAAVEDVVFGCLDTVGPQAGDIARTAWLAAGLPEEVPGVTIDRQCGSSQQAVHFAVQGVLSGTQDLVVAGGTQNMTQIPIAFASRRAAEPLGLTDGPFAGSEGWRARYGDQPVNQFHGAELIARKWGITRRDQEEWALRSHERAIRAIDEGRFARETSAYGDVTFDEGPRRDTTLEKMAGLKPVVEGGTITAACSSQVSDGAAALLLASERAVREHGLTPRARVHHLSVRGEDPIRMLSAPIPATAYALKKTGMSMDDIDLVEINEAFAPVVLAWLKETGTDPEKVNVNGGAIALGHPLGATGAKLMTTLLHELERTGGRYGLQTMCEGGGQANVTIIERL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-06-02" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K0Q5</accession>
    <name>A0A2M9K0Q5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">2,3-dihydroxybiphenyl 1,2-dioxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CG723_06740</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CB01635</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the extradiol ring-cleavage dioxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000002">
        <property type="protein sequence ID" value="PJN12708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN12708">
        <property type="protein sequence ID" value="PJN12708"/>
        <property type="gene ID" value="CG723_06740"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008198">
        <property type="term" value="F:ferrous iron binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019439">
        <property type="term" value="P:aromatic compound catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004360">
        <property type="entry name" value="Glyas_Fos-R_dOase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000486">
        <property type="entry name" value="Xdiol_ring_cleave_dOase_1/2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00903">
        <property type="entry name" value="Glyoxalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00082">
        <property type="entry name" value="EXTRADIOL_DIOXYGENAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0058">Aromatic hydrocarbons catabolism</keyword>
    <keyword evidence="4 6 8" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="5 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VOC" evidence="7">
        <location>
            <begin position="5"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="domain" description="VOC" evidence="7">
        <location>
            <begin position="143"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008784"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PJN12708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="298" mass="32890" checksum="CAB5570F688F4762" modified="2018-04-25" version="1">MDIRSLGFLRIETAKLAEWRTYVIDILGMTEGADSTDTVLHARIDDRIRRLSFVAGEHDRLLSAGFEVANARALAEAAAELEAAGVAVKHADDATLADRRVQGLIHCEDPAGNPLEIYWGQAQDHTPLAAPYGNRFVTGDHLGLGHVVMPAPDMEATLDFYENLLGFQLRDRMKLPPVAVPTGKPGQDFYWMNFLSPGARHHSLGLYPGELPPGIVHFMVELERLDDVGFCLDRMNAAGIPIASTLGRHSNDHMVSFYAQAPGGFQVEYGWDGLIVDKATWVTKEITSDSFWGHRWNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K1H9</accession>
    <name>A0A2M9K1H9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_05005</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000002">
        <property type="protein sequence ID" value="PJN12976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN12976">
        <property type="protein sequence ID" value="PJN12976"/>
        <property type="gene ID" value="CG723_05005"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014889856" evidence="1">
        <location>
            <begin position="25"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN12976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="186" mass="19056" checksum="288B7A53CA12DFA9" modified="2018-04-25" version="1">MPIRRAVVALTVSSALLVGGTACSSNDTKKAKESATVAADVAEPTASSSAEKQKFAKTRFVANAGLAAGATYQWIVKPYRKGKFKKGAHGRKLALVKAGVAGAFAYNRLKAAVKNAKGDPLLSKAVAPLTAGIDKLKDLPSKLRKGDGAAVNSFDDVINSVKDAGKSAGAEVKDKVPSAKELSSGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K1K7</accession>
    <name>A0A2M9K1K7_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Isoleucine--tRNA ligase</fullName>
            <ecNumber evidence="8">6.1.1.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Isoleucyl-tRNA synthetase</fullName>
            <shortName evidence="8">IleRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">ileS</name>
        <name evidence="11" type="ORF">CG723_06280</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CB01635</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7 8">Catalyzes the attachment of isoleucine to tRNA(Ile). As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>ATP + L-isoleucine + tRNA(Ile) = AMP + diphosphate + L-isoleucyl-tRNA(Ile)</text>
            <dbReference type="Rhea" id="RHEA:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:9666"/>
            <dbReference type="Rhea" id="RHEA-COMP:9695"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58045"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78528"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.5"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="8">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="8">IleRS has two distinct active sites: one for aminoacylation and one for editing. The misactivated valine is translocated from the active site to the editing site, which sterically excludes the correctly activated isoleucine. The single editing site contains two valyl binding pockets, one specific for each substrate (Val-AMP or Val-tRNA(Ile)).</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.5" evidence="8"/>
    <dbReference type="EMBL" id="NNBL01000002">
        <property type="protein sequence ID" value="PJN12999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN12999">
        <property type="protein sequence ID" value="PJN12999"/>
        <property type="gene ID" value="CG723_06280"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002161">
        <property type="term" value="F:aminoacyl-tRNA editing activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004822">
        <property type="term" value="F:isoleucine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006428">
        <property type="term" value="P:isoleucyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07961">
        <property type="entry name" value="Anticodon_Ia_Ile_ABEc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.740.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02003">
        <property type="entry name" value="Ile_tRNA_synth_type2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002300">
        <property type="entry name" value="aa-tRNA-synth_Ia"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033709">
        <property type="entry name" value="Anticodon_Ile_ABEc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002301">
        <property type="entry name" value="Ile-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023586">
        <property type="entry name" value="Ile-tRNA-ligase_type2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013155">
        <property type="entry name" value="M/V/L/I-tRNA-synth_anticd-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009008">
        <property type="entry name" value="Val/Leu/Ile-tRNA-synth_edit"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42780">
        <property type="entry name" value="PTHR42780"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08264">
        <property type="entry name" value="Anticodon_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00133">
        <property type="entry name" value="tRNA-synt_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00984">
        <property type="entry name" value="TRNASYNTHILE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="SSF47323"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50677">
        <property type="entry name" value="SSF50677"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00392">
        <property type="entry name" value="ileS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="4 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 8 11" id="KW-0436">Ligase</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="tRNA-synt_1" evidence="9">
        <location>
            <begin position="14"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="domain" description="Anticodon_1" evidence="10">
        <location>
            <begin position="677"/>
            <end position="822"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'HIGH' region" evidence="8">
        <location>
            <begin position="44"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'KMSKS' region" evidence="8">
        <location>
            <begin position="590"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="593"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF08264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PJN12999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="1037" mass="115902" checksum="FE75E8C113ED948D" modified="2018-04-25" version="1">MPAQVDLPALEHAVLDFWREQKIFAKSLEQSEGRPEWVFYEGPPTANGMPGAHHIEARVFKDVFPRFRTMRGYHVARKAGWDCHGLPVELAVEQELGFNGKKDIEAFGIAEFNAMCRESVTRHTDAFTDLTTRMGYWVDLDDAYRTMDPAYIESVWWSLKEIFNKGLLTQDHRVAPWCPRCGTGLSDHELAQGYETVVDPSVYVRFPLTSGPLAGEASLLVWTTTPWTLVSNTAVAAHPDVTYVVATDGNEKVVVAEPLVEKSLGEGWEKTGESFTGAEMERWKYQRPFELVEFPAEAHYVVNADYVTTEDGTGLVHQSPAFGEDDLKVCKSYGLPVVNPVRPDGTFEEDVPLVGGVFFKKADEKLTEDLKDHGLLFLHVPYEHSYPHCWRCHTALLYYAQPSWYIRTTEIKDRLLQENEKTNWFPSSVKHGRFGDWLNNNIDWALSRSRYWGTPLPLWRCEDDHLTCVGSLAELGELTGTDLADLDPHRPFIDEVTFACPQCEKTATRVPEVIDAWYDSGSMPFAQWGYPYKNKELFESRYPAQFISEAIDQTRGWFYTLMAVGTLVFDKSSYENVVCLGHILAEDGRKMSKHLGNTLQPIPLMDQHGADAVRWFMAAGGSPWAARRVGHGTIQEVVRKTLLTYWNTVAFQALYARTSDWSPSEADPAPADRTLLDRWLLSELHALTDQVTQALEAYDTQRAGKLLSSFVDDLSNWYVRRSRRRFWQGDKGALRTLHEVIETVTRLMAPLTPFITERVWQDLVVPVTPDSPESVHLSTWPEADLSAIDPDLSRQMVLVRRLVELGRATRAESGVKTRQPLSRALVAAAGFETLNPELHAQITEELNVSSLASLSEVGGSLVDTTAKANFRALGKRFGKGVQAVAKAVAEADAAALSLGLREGTASVEIDGETITLAPDEVIITETPREGWSVASDSGATVALDLEITEELRQAGLARDAIRLIQEARKNSGLDVADRIALRWTSTEPAVVSALSEHATLIADEVLATDFAQGEADDTYGETFTDEPLALTFRLRKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K1L1</accession>
    <name>A0A2M9K1L1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CG723_07895</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000002">
        <property type="protein sequence ID" value="PJN12917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN12917">
        <property type="protein sequence ID" value="PJN12917"/>
        <property type="gene ID" value="CG723_07895"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10540">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003673">
        <property type="entry name" value="CoA-Trfase_fam_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044855">
        <property type="entry name" value="CoA-Trfase_III_dom3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023606">
        <property type="entry name" value="CoA-Trfase_III_dom_1_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02515">
        <property type="entry name" value="CoA_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89796">
        <property type="entry name" value="SSF89796"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PJN12917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="468" mass="49151" checksum="31ABDCD52CA856EE" modified="2018-04-25" version="1">MTHAPVGEGTRTAWAALGGDPALTSNIASVVREGALPARLPVIDLARACVGACSLAAAELAARRAGRPLPRVVLDDGALATAFVSERHLLIDGRATVNFAPLSRFWRTADGWLRTHANYPHHRARLLAALGLGDDASVERVAALFAERSAAEIEETVYAAGGLAVALRTMEEWAAHPQGEAVAGRPLLDRERLDDAAPRSLSPLTGDPLLPADGLRVLDLTRVTGGPVATRTLALFGADVLRVDAPQLPEDPEAHADTGSGKRSTRLDLTGAADRRAFDDLLAGADVVVTGYRPGALDRFGLAPGALASRRPGLVVAQLSAWGAYGPWGERRGFDSVVQVATGIAAVEGSGERPGALPAQALDHGTGYLLAAAVLRAVTEQLDEGGTRALRLALARTAHWLTRELQHGPTAATETYDAEDPARWLTETDSPAGRLRHALPPAGFTGGPVNWARPSGLWGTDSPEWRHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K1X1</accession>
    <name>A0A2M9K1X1_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 8 10">Thymidine kinase</fullName>
            <ecNumber evidence="2 8 10">2.7.1.21</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">tdk</name>
        <name evidence="12" type="ORF">CG723_00545</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">CB01635</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8 10">
            <text>ATP + thymidine = ADP + dTMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19129"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17748"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:63528"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.21"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 8 11">Belongs to the thymidine kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.21" evidence="2 8 10"/>
    <dbReference type="EMBL" id="NNBL01000001">
        <property type="protein sequence ID" value="PJN13126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN13126">
        <property type="protein sequence ID" value="PJN13126"/>
        <property type="gene ID" value="CG723_00545"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004797">
        <property type="term" value="F:thymidine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071897">
        <property type="term" value="P:DNA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00124">
        <property type="entry name" value="Thymidine_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001267">
        <property type="entry name" value="Thymidine_kinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11441">
        <property type="entry name" value="PTHR11441"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00265">
        <property type="entry name" value="TK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF035805">
        <property type="entry name" value="TK_cell"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 8 10" id="KW-0237">DNA synthesis</keyword>
    <keyword evidence="6 8 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 8 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8 10" id="KW-0808">Transferase</keyword>
    <feature type="active site" description="Proton acceptor" evidence="8 9">
        <location>
            <position position="87"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="9"/>
            <end position="16"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="86"/>
            <end position="89"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR035805-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PJN13126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="216" mass="23474" checksum="5192955BEC5DCD04" modified="2018-04-25" version="1">MPELVFFSGTMDCGKSTLALQIEHNRSARGLKGMILTRDDRAGEGKLSSRLGLVTDAVEVADDLDVYAYVVDQLSQGGRVDYVIADEAQFLAPEQIDQLARVVDDLGLDVYAFGITTDFRSKLFPGSQRLVELADRVEVLQVEALCWCGARATHNARTVGGRMVVEGAQVVVGDVDRSDDEVGYEVLCRRHHRKRLTSATAHAAALSPEVLPIASA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K2C4</accession>
    <name>A0A2M9K2C4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CG723_00865</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000001">
        <property type="protein sequence ID" value="PJN13177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN13177">
        <property type="protein sequence ID" value="PJN13177"/>
        <property type="gene ID" value="CG723_00865"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PJN13177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="853" mass="91742" checksum="7569E08D56FE7D35" modified="2018-04-25" version="1">MTGPTTPESLWFLRVNPLRRARLADPAQRRTLAELAAAEEELRQAADACSDELYHRIGEAADDAERRDLIALRRSIHNGRAPKKPPTPTPAVTHWLAARDTRERLRDAVVEGYPEAADRERAGLAALLGDDDLLRSLALVAPEVHQEAERYRAAVLGPGKVSARTRKSERGLIQYVTRAMVRTSPLSRFTAVGIAEPDPDGVDPGDVPFEGATAFPGLDRVMLGYVLGGLPAADTADLTDLWVGIPPTSAPDPESGKLFFLRLTDAGMRRLAVPLDGPVGDLLDAVSMGPRLFPAVVAHVAERAGIPAEAADKRVRQAVGQGLLCTFHEAEDGAADYDDLLTPDDPRATTLAAGIRAGLPRLAEAPAPERGGVLAELRGDLGKLSHLAGRPAQITVEEDYVMPPQKVATRQWHKPLADLGPAVELLSVFDWLHDVRVLMTAAFVERFGAGANIPLAANAAFVVGEVSRRAAAMDAVYGPHGTGDPSALAGIGPADGSLERMYLLRRELTEAVHARLSKTVDAGDDTLVLTPDDVTGLTASLPDRFRQDPLIYGVLLQEGDGRLVLNDGLPGHGMLYARFLDADRRMGGRALPRLAEHLRREYGFDGARVTEDLGLHRLNVNAHAPILPGGLTPEDWFTLRLAHDPDTDTLRVEDADGAPLRVLPLGTGHPGLFPPPLSVASGLAISGRLFNSLPNSWHAATPWDRATTRTAPRMAVGDVLIGRRRWYGGDELTTAVAAGPDEHDRLLALNAWRARHAVAEEVVIKNAPEDEGPLSVGAPDVQSKRLQQKPQYVDLTSALSARVLPRMLDRRGADGCYLEEALPAVVDGTHATEWVVEVGREAGGRFTYRGGQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-09-29" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K2V9</accession>
    <name>A0A2M9K2V9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Acyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_02520</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000001">
        <property type="protein sequence ID" value="PJN13462.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN13462">
        <property type="protein sequence ID" value="PJN13462"/>
        <property type="gene ID" value="CG723_02520"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006807">
        <property type="term" value="P:nitrogen compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003010">
        <property type="entry name" value="C-N_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036526">
        <property type="entry name" value="C-N_Hydrolase_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00795">
        <property type="entry name" value="CN_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56317">
        <property type="entry name" value="SSF56317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50263">
        <property type="entry name" value="CN_HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="CN hydrolase" evidence="1">
        <location>
            <begin position="5"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN13462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="280" mass="31767" checksum="F1E2337C30FC6092" modified="2018-04-25" version="1">MAHVVRAALVQATWTGDTESMITKHEEHAREAARQGARIIGFQEVFNAPYFCQVQEAEHYRWAEPVPDGPTVTRMQALARETGMVVVVPVFEVEQSGFYFNTAAVIDADGTYLGKYRKHHIPQVKGFWEKYYFKPGNLGWPVFETAVGRVGVYICYDRHFPEGWRQLGLNGAQLVYNPSATSRGLSGYLWQLEQPAAAVANEYFIAAINRVGVEEYGDNDFYGTSYFVDPRGQTVGDAASDKDEELLVRDLDFGLIDEVRQQWAFYRDRRPDAYEGLVQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K2W7</accession>
    <name>A0A2M9K2W7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Nitrate reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CG723_02550</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CB01635</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the purine-cytosine permease (2.A.39) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000001">
        <property type="protein sequence ID" value="PJN13468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN13468">
        <property type="protein sequence ID" value="PJN13468"/>
        <property type="gene ID" value="CG723_02550"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012681">
        <property type="entry name" value="NCS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001248">
        <property type="entry name" value="Pur-cyt_permease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045225">
        <property type="entry name" value="Uracil/uridine/allantoin_perm"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30618">
        <property type="entry name" value="PTHR30618"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02133">
        <property type="entry name" value="Transp_cyt_pur"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00800">
        <property type="entry name" value="ncs1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="48"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="77"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="168"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="198"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="236"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="278"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="318"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="361"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="384"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="432"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="482"/>
            <end position="499"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PJN13468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="506" mass="54436" checksum="B85521D0F486A1C9" modified="2018-04-25" version="1">MTDTAPPTLPAGGGIDLSADAYPSDSRYANDDLRPVPLAERRWTTYNFVALWIGMAHCIPSWTLASGLVALGMDWKQAVLTIGLANVIVLLPMLLTGHAGPKYGIPFPVLARASFGLRGANLPALIRAAVACCWFGIQTWIGGQGVFVLLGKVFGGWADVSHVGGYPWTLWLCFVLFWVLELAIIYRGMDTLRRFENWAAPFVLVGAVVLLVWIANKAGGFGPLLDEPSKVGWGSDFWKIFFPGLMGMIGFWSTLSLNIPDFTRFGKGQRAQVWGQTLGLPTTMTLFALMSVLVTSGSEKVYGAAIWDPVALAGKTDNVFGLLFALITVFVATISVNIAANVVSPAYDLANLAPKLINFRTGALITGVIGVLVMPWKLTSTPELYIFTWLGVVGGLLGTVAGILIADYWIIRRTVLHLADLYLQNGRYWYSGGWNWNAVIAFAVGGVLAVGGSYSTVDAQGAKQGPFPVDGLIPFLKPLADYGWAVGLGSSLILYVALAKARGVRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K3A7</accession>
    <name>A0A2M9K3A7_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Phospholipase C</fullName>
            <ecNumber evidence="2">3.1.4.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CG723_03390</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CB01635</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O = a 1,2-diacyl-sn-glycerol + H(+) + phosphocholine</text>
            <dbReference type="Rhea" id="RHEA:10604"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17815"/>
            <dbReference type="ChEBI" id="CHEBI:57643"/>
            <dbReference type="ChEBI" id="CHEBI:295975"/>
            <dbReference type="EC" id="3.1.4.3"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="5">
            <dbReference type="Rhea" id="RHEA:10605"/>
        </physiologicalReaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial phospholipase C family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.4.3" evidence="2"/>
    <dbReference type="EMBL" id="NNBL01000001">
        <property type="protein sequence ID" value="PJN13611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN13611">
        <property type="protein sequence ID" value="PJN13611"/>
        <property type="gene ID" value="CG723_03390"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034480">
        <property type="term" value="F:phosphatidylcholine phospholipase C activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044003">
        <property type="term" value="P:modulation by symbiont of host process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017767">
        <property type="entry name" value="Bact_PC-PLC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007312">
        <property type="entry name" value="Phosphoesterase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008475">
        <property type="entry name" value="PLipase_C_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31956">
        <property type="entry name" value="PTHR31956"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05506">
        <property type="entry name" value="DUF756"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04185">
        <property type="entry name" value="Phosphoesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03396">
        <property type="entry name" value="PC_PLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0134">Cell wall</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4" id="KW-0843">Virulence</keyword>
    <feature type="domain" description="DUF756" evidence="7">
        <location>
            <begin position="496"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="domain" description="DUF756" evidence="7">
        <location>
            <begin position="594"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="459"/>
            <end position="505"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF05506"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PJN13611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="685" mass="74126" checksum="611BB8587A470C5D" modified="2018-04-25" version="1">MPELNRRRFLQIAGATAGFTALSNSIDRAAAIPAARVKGTVQDIEHIVVLMQENRSFDHYFGTMKGVRGFGDPRPVTLPSGKPVWNQASGAKEVLPYHPDAADLGMQFIAGLDHDWAGGHSAFNNGKYDNWIAAKGTGTMAYLTRQDIPFHYALADKFTVCDDYHCSFMGATDPNRYYMLSGHVGNDGTGGGPVLGNQEAGYGWTTYAERLEKAGVSWKVYQDIGDGLDAAGSWGWIDDAYRGNYGDNSLLYFNNYRNAKPGDPLYDKARTGTNAKAGDGYFDVLKADVKAGKLPKISWIAAPEAFSEHPNWPANYGAWYISQVLDALTSNPDVWSRTALFITYDENDGYFDHVVPPYAPASANQGLSTADTTLDYFKGNASYSAGPYGLGQRVPMIVVSPWSTGGYVCSETLDHTSILRFMEKRFGVKETNISPWRRAVCGDLSTAFDFSLTNTTPAQLPSTAGYLPPDHDRHNSYVPKPPASPVLPKQESGSRPARPLPYAPYVDGVSTPSTGKFQLTFSGGPSAGAAFQVRSLNRTDGPWTYSTEAGKSISDAWNSTYSAGKYDLTVHGPNGFLRAFKGTNTVAEPGLTARHDASTGNLTLTLTNPTGADVHLTVTNAYGGQPQTYTVRAGATVTQTVDLRATKRWYDLKVTADSDSTYLRRLAGHVENGQAGVSDPGILTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K3E0</accession>
    <name>A0A2M9K3E0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CG723_03615</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000001">
        <property type="protein sequence ID" value="PJN13646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN13646">
        <property type="protein sequence ID" value="PJN13646"/>
        <property type="gene ID" value="CG723_03615"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PJN13646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="106" mass="10756" checksum="E819758DB454BF31" modified="2018-04-25" version="1">MALVSLPLEFHLKVGQLGASVALFAAGVVGRARRWAGDQEAAAPGSEQLPQPCQCAPVRPRADLAAGPRGPVAAAETDLRTCVSELASDLASRLGSESQGGGMAHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K3E6</accession>
    <name>A0A2M9K3E6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Amino acid oxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CG723_03645</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CB01635</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 4">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DAMOX/DASOX family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000001">
        <property type="protein sequence ID" value="PJN13651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN13651">
        <property type="protein sequence ID" value="PJN13651"/>
        <property type="gene ID" value="CG723_03645"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003884">
        <property type="term" value="F:D-amino-acid oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046416">
        <property type="term" value="P:D-amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006181">
        <property type="entry name" value="D-amino_acid_oxidase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023209">
        <property type="entry name" value="DAO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11530">
        <property type="entry name" value="PTHR11530"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000189">
        <property type="entry name" value="D-aa_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00677">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="4" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DAO" evidence="5">
        <location>
            <begin position="8"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="44"/>
            <end position="45"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="157"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="174"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="218"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="273"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="299"/>
            <end position="304"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="300"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000189-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PJN13651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="319" mass="33773" checksum="FC6272985652B0F2" modified="2018-04-25" version="1">MDSDASSDVIVVGGGVIGLTTALELVRMGRRVRVWTRDPAALTTSAVAGALWWPYRIDPVERVSDWSLRSLRVYEELAAQRGPAGVRMAEGVQADTLLEGLGPWADGVAGLRPATPAEYGGGTGLWARLPLVDMPVHLEWLKERFLAAGGRVETREVTDLAEAGSQAPVVVNCTGAGARALVPDDAVRPLRGQLVLVENPGVDTWFVGGGDSPDTSTYFFPQPGRLILGGTAQEDDWSLEPDPAVAEAIVARCARVRPEIAGARVIGHRVGLRPTRPEVRVERERASWGGVLVHNYGHGGAGVTVAWGCAQEAAGLAVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K3I3</accession>
    <name>A0A2M9K3I3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CG723_03240</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CB01635</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">In the N-terminal section; belongs to the NADH:flavin oxidoreductase/NADH oxidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000001">
        <property type="protein sequence ID" value="PJN13587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN13587">
        <property type="protein sequence ID" value="PJN13587"/>
        <property type="gene ID" value="CG723_03240"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001155">
        <property type="entry name" value="OxRdtase_FMN_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00724">
        <property type="entry name" value="Oxidored_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Oxidored_FMN" evidence="2">
        <location>
            <begin position="9"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="domain" description="Pyr_redox_2" evidence="3">
        <location>
            <begin position="391"/>
            <end position="620"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PJN13587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="655" mass="69145" checksum="82F46D596593E717" modified="2018-04-25" version="1">MTSTAFPHLFSPLAIGGVTLKNRVLSSGHDTVLVEGGQVTDDLVAYHEARAEGGVGLIVVQVAGVHETARYTTHVLMATDDSCVEGYRRLAEAAHRHGAKVFGQLFHPGREILESRDGSAPVAWSASATPSERFHVMPHAMTETEIREVVDGYGEAARRLRAAGLDGVEVVASHGYLPAQFLNPQVNVRTDGYGGDADGRLRFLREALASVRAHTGPDFVAGLRISGDELSHDGLTAELAVEASERLDREGLVDYVSVCAGSSATISGAVHIAPPMTQPAGYTAPIAARVRAAVGVPVMVAGRVNQPQEAEQIIRECQADACAMTRALICDPDMPGKASDGRTEEIRACIGCNQACIGHFQRGYPISCIQHPETGRERRFTRLPLPTRRRRVLVAGGGPAGLKAAAVAASRGHDVTLHEAGRRVGGQVLLAQLLPGRAEFGGAITNLEGEARRAGARIVTGSRVDAELLDREQADTLIVATGAVPRRPALELLDDPVVLDAWDVVRGTADVPKGRIVVADWRGDWIGIGVAVQLARQGRKVTLCTTGFGAGEHLQQYVRASMLAEAARAGVETVPTVRPYGADADTAYFQHTLTEEPVIIEGVAAVVLAQGHDPVGELAGLADGRVGEVLMAGDCVSPRTVEEAVLEGLTVASSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-09-29" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9K3M8</accession>
    <name>A0A2M9K3M8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Peptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_03810</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000001">
        <property type="protein sequence ID" value="PJN13680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN13680">
        <property type="protein sequence ID" value="PJN13680"/>
        <property type="gene ID" value="CG723_03810"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00118">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.70.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.350.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011055">
        <property type="entry name" value="Dup_hybrid_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018392">
        <property type="entry name" value="LysM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036779">
        <property type="entry name" value="LysM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016047">
        <property type="entry name" value="Peptidase_M23"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01476">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01551">
        <property type="entry name" value="Peptidase_M23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00257">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51261">
        <property type="entry name" value="SSF51261"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54106">
        <property type="entry name" value="SSF54106"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51782">
        <property type="entry name" value="LYSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014780116" evidence="1">
        <location>
            <begin position="42"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="domain" description="LysM" evidence="2">
        <location>
            <begin position="61"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN13680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="268" mass="26775" checksum="9571858EADD62677" modified="2018-04-25" version="1">MPAKGKHRRPKSQGFARTIVVAGVGGAALALPLMGATGAHAATPAAAHSVAQSVAAPAVAKTYAVKGGDTLSKIADEQNVSGGWKKLYSDNRSVIGGDPSVIHPGLKLTIGQKAAATATQASAPKAAAATTTGSGYTLPVQGASIGTAYKTAGAMWSSGYHTGVDFVIPTGTPLKAIAAGTVVSAGLDGAYGNEVVIQHADGKYSQYAHMSSLSVSSGQTVTEGQQIGLSGATGNVTGPHLHFEIRTTPSYGSDVDPVAYLRGHGVSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JEH6</accession>
    <name>A0A2M9JEH6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_45590</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000059">
        <property type="protein sequence ID" value="PJN05300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN05300">
        <property type="protein sequence ID" value="PJN05300"/>
        <property type="gene ID" value="CG723_45590"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002798">
        <property type="entry name" value="SpoIIM-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01944">
        <property type="entry name" value="SpoIIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="102"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="168"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="259"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="289"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN05300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="335" mass="35993" checksum="DFFD8512BFFE8008" modified="2018-04-25" version="1">MDLDVFVSAHRAEWDRLDALLRRRRRLTGAEADELVTLYQRAATHLSLIQSSAPDPQISGRLTQLVARARSAVTGTRRASWRDVTRFLTQGFPAAVYRSRHWWVPTALLSTAIAALLGWWIGTHPEVQASIAAPSELRDLTRPGGQYETYYSSHPAASFAAQVWTNNAQAAAMCLVLGVFLGLPVLWILFQNMLNLGVGIGLMSSAGRLDTFLGLVLPHGLLELTAVFVAAGTGLRLGWTLIDPGPRTRRAALAEEGRAALGMAIGLALILFISGAIEGFVTPSGLPTWARITIGVLAELAFLVYVYVLGGRAARAGETGDLDKAERSASVPTAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JEM1</accession>
    <name>A0A2M9JEM1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CG723_45470</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000054">
        <property type="protein sequence ID" value="PJN05328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN05328">
        <property type="protein sequence ID" value="PJN05328"/>
        <property type="gene ID" value="CG723_45470"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PJN05328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="69" mass="7932" checksum="514EBA8B63F882B5" modified="2018-04-25" version="1">MGHRFGRADLRRRMRDHVRALLGPVGRKNGRQLAEYAGHHTPDGLQRLLNGATWDADDARDEVPDLYWP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JEN5</accession>
    <name>A0A2M9JEN5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DUF3558 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_45400</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000053">
        <property type="protein sequence ID" value="PJN05339.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN05339">
        <property type="protein sequence ID" value="PJN05339"/>
        <property type="gene ID" value="CG723_45400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014967898" evidence="2">
        <location>
            <begin position="30"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="79"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="145"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="234"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="239"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN05339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="289" mass="29300" checksum="F67085A75771AA19" modified="2018-04-25" version="1">MHRPTKRLTRIFVCAAAVPVILVASGCSSDSGDGADKGSSKASASASDAAAKVKAAAYDSLPQPCAAISKKTLDSLVPEAKSGKAGSSDDESVRGTCSWSSLDNKGVKGSQFRWLNASLMRFDSDAARGSGNKLAHAYFTKQVTDAQSVDGAKSPKSEPVSGTGDEATAVTYELKKKEGTFKQQTVVARVENVVVTIDYNGAGLAGEKTPGTDELVKDAEKAAKEAVAAVVAANGAGGSDTAGSASAKPSDKTSSKPSAKPSEKSSAKTSSKPSAKSSDEPSDKASAKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JES6</accession>
    <name>A0A2M9JES6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CG723_45515</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000056">
        <property type="protein sequence ID" value="PJN05313.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN05313">
        <property type="protein sequence ID" value="PJN05313"/>
        <property type="gene ID" value="CG723_45515"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PJN05313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="174" mass="19364" checksum="DA439B4593BDEA18" modified="2018-04-25" version="1">MAWIDEKRYGEDETVLVYFKGTSLAAMAEGLSAQHRPPFAYGNDTAPGGWGVIVHHMFNPSRDDYDGIDYRELCPQGAELMVFVPNPCIAKAHGPKGYHYKDGQISSCIDYEGPDCVGEYWPNKLAPLITAAGLDHQNEIYEEQLTQLICDHLGLPALDRDTITVDRDLVASYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JF33</accession>
    <name>A0A2M9JF33_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">3-alpha-hydroxysteroid dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CG723_44350</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000047">
        <property type="protein sequence ID" value="PJN05479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN05479">
        <property type="protein sequence ID" value="PJN05479"/>
        <property type="gene ID" value="CG723_44350"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PJN05479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="262" mass="26470" checksum="75EA0384963DD253" modified="2018-04-25" version="1">MTTGSGSSERLAGRAAIVTGGARGIGAAITRCLAAAGARVVIADVLDSEGAALATELGAAARYAHVDVRRRDDWESAVALSREVFGLPLSVLIHNAGVMTPGTVASTDEESLTLALDVNLLGPVIGTQVCLPGMIDGGGGSVVVMSSIASLSVGPGFIPYAVSKAANAVYARAAARELGPHGIRVNSLHPGGVETPMNSGPGFAALDKDAWFGRMPIPRIGRPAEIAAAALFLASDDSSYVTGTQLVVDGGQLLGPRATWDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JF50</accession>
    <name>A0A2M9JF50_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CG723_44215</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000046">
        <property type="protein sequence ID" value="PJN05526.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN05526">
        <property type="protein sequence ID" value="PJN05526"/>
        <property type="gene ID" value="CG723_44215"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PJN05526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="170" mass="19288" checksum="96C404FEE0755370" modified="2018-04-25" version="1">MRRPQCGLGADDGRQRPFLVRVQFIAEDPARVIANARAVLACVVQRTGDWPAFGRWSELLPAEFMQRCAPEPEPDPSFDVQAWLQTWQAMTPEPKSAFSQEPWTLSDWLYYFDPTEDGMGDDRSWWWWDAGSDEPGNGWVEVATTGWPFGSGSLSWLIKASGGRDLDYRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JF87</accession>
    <name>A0A2M9JF87_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CG723_44295</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000046">
        <property type="protein sequence ID" value="PJN05539.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN05539">
        <property type="protein sequence ID" value="PJN05539"/>
        <property type="gene ID" value="CG723_44295"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002514">
        <property type="entry name" value="Transposase_8"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01527">
        <property type="entry name" value="HTH_Tnp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PJN05539.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="100" mass="10837" checksum="B84D501BA25373CB" modified="2018-04-25" version="1">MLVVMAEKRRVFTAEFREGAVRIVTEAGKPVPEVAEDLGINETTLASWESASSGEARNLVDGRGEVVPQDRGAYFAAEGRAQEAGHGQVVTLPPFARIRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JFB4</accession>
    <name>A0A2M9JFB4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CG723_44055</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CB01635</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000045">
        <property type="protein sequence ID" value="PJN05578.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN05578">
        <property type="protein sequence ID" value="PJN05578"/>
        <property type="gene ID" value="CG723_44055"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="63"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="97"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="146"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="205"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="254"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="59"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PJN05578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="292" mass="32127" checksum="494EF25FDE45E0F6" modified="2018-04-25" version="1">MASFLVPFLVLYLGFTLWPLAATVCYSFFDWSGTGPLDTYVGGGNYQRILSDPLFWQAVVNTLLFAIGTTVVKLPLSLLAALVMTRKWLRAKKALRTVFFAPLIIPVAMAGLVFTYLLNPSNGALNSALHKLGLTDGTTDVFANRWTAMAALVLISVWQVFGQYMIYWMAALQNVPEELYEAAALDGASEWQKLTRITLPMIRPVAVVIVMLALVNAMHVFGLVVTLTGGGPGTNTYVVSYFIYKQAFGSMPFAYGYASAAALLFSVMAFLLVMSQGYFVRRAQKTRKEYGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JFM1</accession>
    <name>A0A2M9JFM1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CG723_43515</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CB01635</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000043">
        <property type="protein sequence ID" value="PJN05681.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN05681">
        <property type="protein sequence ID" value="PJN05681"/>
        <property type="gene ID" value="CG723_43515"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008969">
        <property type="entry name" value="CarboxyPept-like_regulatory"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49464">
        <property type="entry name" value="SSF49464"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="37"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="71"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="102"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="131"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="163"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="189"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="229"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="252"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="295"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="330"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="359"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="384"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="497"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="7">
        <location>
            <begin position="36"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PJN05681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="845" mass="85919" checksum="316DB167B3DE04FA" modified="2018-04-25" version="1">MATTTPAGVRGSHAKHGGAAAPGSGTPMTHKQIMEALSGLLLGMFVAILSSTIVTNALPEIVGDLGGGQSAYTWVVTASLLAMTATTPLWGKLADIFSKKALVQIALIVYVGGSVVAGLSQSPTMLIACRVVQGIGVGGLSALAQIVMAAMISPRERGRYSGYLGATFAVATVGGPLLGGVITDTSWLGWRWCFYVGVPFAIIALIVLQKTLKLPVVKRDNVKVDWAGAFFITAAVCTLLLWVTFADDKYDWLSWQTGAMVGGAVVLALIFIFVETKAAEPIIPLRLFRNRTITLASIASLFVGVAMFTGTVFFSQYFQLARGKSPTMSGVMTIPMIGGLFISSTVAGQVITKTGKWKAWLVSGGVLITAGLGLLGTIRYDTAYWHVAIYMALMGLGIGMMMQNLVLCTQNQVAPEDIGSASSTVTFFRSLGGAMGVSALGSIMATRITHYVKDGLTDLGPKGAALGHGGTGGGAIPDLDKLPAPLRTIMESSYGHGIADVFLIAAPIALLALIATLFIKEIPLRTSNSQAVPAAESESGAPVAAVAGAPETEELVPAMAAAVSAPSSDGSTQRLQAVATTAGSVPATASTGGGTPVRGFVRGSESAPVPRAAVTLISLGGRQLGRAVSQGDGAYGLDAPGAGSYVLIASADGYQPQASTVVVGEEPVAYDILLSGTSGLSGVVKSVDSKLPVPGAMVIVTDVRGDVLATGLSGEQGEFTFAELVPGAVTVAVNAAGHRPLALPVEVGGTGVTRVEIELHSGAQVAGVVRAAGGALNDARVTLVDAAGNVVATATTGHDGAYAFTDLDSGEYTVIATGYPPVATGLTVNGGGAEGHDIELAHPGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-09-29" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JFW9</accession>
    <name>A0A2M9JFW9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Chromosome partitioning protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_42885</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000041">
        <property type="protein sequence ID" value="PJN05779.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN05779">
        <property type="protein sequence ID" value="PJN05779"/>
        <property type="gene ID" value="CG723_42885"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025669">
        <property type="entry name" value="AAA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13614">
        <property type="entry name" value="AAA_31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA_31" evidence="2">
        <location>
            <begin position="135"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="38"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="104"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="38"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN05779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="389" mass="42019" checksum="077BE55203ED817A" modified="2018-04-25" version="1">MNESTFTPGGGQPGTVAREQGPAGLEAVGSVAVRTFAARQSSPLQTQTAPQSMDGHHVNAMAGDRSGERTHFADYDELPEGHFYDPDAEYEPDPEYAATLAPDAARQRRERVGPTGRPLPYFPIPGPLTDHGPAKIIAMCNQKGGVGKTTSTINLGAALAEYGRRVLLVDFDPQGALSVGLGVNPMELDLTVYNLLMERGMAADEVLLKTAVPNMDLLPSNIDLSAAEVQLVSEVARESTLQRALKPLMADYDYIVIDCQPSLGLLTVNALTAAHKVIVPLECEFFALRGVALLTETIEKVQERLNPDLELDGILATMYDSRTVHSREVLARVVEAFDDHVYHTVIGRTVRFPETTVAGEPITTYASNSVGAAAYRQLAREVLARCHAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JGU1</accession>
    <name>A0A2M9JGU1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Recombinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_40840</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000035">
        <property type="protein sequence ID" value="PJN06098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN06098">
        <property type="protein sequence ID" value="PJN06098"/>
        <property type="gene ID" value="CG723_40840"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015378">
        <property type="entry name" value="Transposase-like_Mu_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09299">
        <property type="entry name" value="Mu-transpos_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="2">
        <location>
            <begin position="145"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="408"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="426"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="471"/>
            <end position="495"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN06098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="528" mass="59411" checksum="1391E41BDFFE3E2D" modified="2018-04-25" version="1">MPDHEPRLDQTPLRQTAIAQLLHLHDSGTLTRHHKHLAAQAFNRNIKTIEKWMKNAQQHHGHYTPQPRTTLRLTPAIHDALARWCGNIAAAYRELRTEGHLEIPSQPGRHYSYATLRRTIQRELDLGHLAGLKGGETARRRHDVHNTRPRGHRNEAWEGDHKTADMNVTLGNKIVTPVITWFADCSTDVICGLAVTPHAPSRDAILTALRAAILRGPHYGPFGGVPGLIRIDRGRDFLCSTVEEAIGYFGAERVDLPPRHPELKGTIEAINNAVSCMHFKGLPGYTQRPSTEPRGKNRRPNPADLLTFEDFVARLLDWVNVWNHEHRIRTLNNRTPAQAWADDLTPVRDVPPEALYTFTLRANRTSHTILGDGIHWHDRVYLDDWMNGKVGTKAVVRYMPHHPQRIELTHPTTGRYLGPGFDQTTPDPEAEERRRALRRKRERSARDLASRLKKTNKSLSERYGPVTTASAPTPIHPPTEPPPHPTAPPDTQRPLPAPSASWHTPAAPTTSEGDTDAPSDDEDRDANP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JGY4</accession>
    <name>A0A2M9JGY4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">ArsR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CG723_41135</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000036">
        <property type="protein sequence ID" value="PJN06017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN06017">
        <property type="protein sequence ID" value="PJN06017"/>
        <property type="gene ID" value="CG723_41135"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PJN06017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="165" mass="18347" checksum="F3C8A2D900449748" modified="2018-04-25" version="1">MTERRLATDAEAKALASALRLRILRICLGEARTNKEIAAILGGDPASVLHHTRTLVRTGFLEAQEERRGARGAREIPYLATRKSWQLDAAAQDRSMLDAFLEELALAPATEVDSTRLGLRLPPAEMEEFQTRLRALLEEFAARPDDPTAPAWSLFIVVHPDPNRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JHF0</accession>
    <name>A0A2M9JHF0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">AMP-dependent synthetase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_39895</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000032">
        <property type="protein sequence ID" value="PJN06308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN06308">
        <property type="protein sequence ID" value="PJN06308"/>
        <property type="gene ID" value="CG723_39895"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-binding" evidence="1">
        <location>
            <begin position="72"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding_C" evidence="2">
        <location>
            <begin position="490"/>
            <end position="577"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN06308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="597" mass="63287" checksum="B0930B7744A897B9" modified="2018-04-25" version="1">MATPFGAAVDSAGSPHLLRPGLSGFRTFLEPTRRAWCATARTQHVNQSARRRGPHAVPHFTYPELPLDGLLRRAAARDPHAPALTTGRGTVTYGQLDAHADRIARFLARAVGRRGAVVGVANTLDPVFPAAYYGTSRSGNTVALINPLVNEHALHHVCAAAGVEIALVPAATGEQLMKMRDRLPLLHTIVVTDADHAVVPGDTVPLHVALDETPDGPYERDEPAAVDPSSVVCIQFTTGTTGRPKGVRLTHRNLVANATQTALAQSLGCGSVTLNHLPLFHVMHLNSAVCAGASQVLCHDPDPVASLALAAREGATHYYGLPARLHRLADDPRLTTACEGVPAGPRLTAVMSGGTALAPTAARRLRQALGVPVVQGYGLAELSPLSHMQRPADPAVRGAVGPPLPGTECRVVDLGSREPVAVWATGEVQVRGPQVMAGYLNDDEPSRIDADGWFSTGDAGWLDEDGRLFLVDRLGDVFKYDNELVSPTGVERIIAEDPRVAECVVVGWPDAVHGAVVWAGIVLRDPTGTARRAAYTGLDTLDALDAVAEEANRRLAPFERIRRVEALDAVPRTPTGKPERQALRQKVRALAAAEAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JHI1</accession>
    <name>A0A2M9JHI1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Polyketide beta-ketoacyl:ACP synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CG723_40020</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CB01635</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000032">
        <property type="protein sequence ID" value="PJN06334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN06334">
        <property type="protein sequence ID" value="PJN06334"/>
        <property type="gene ID" value="CG723_40020"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000794">
        <property type="entry name" value="Beta-ketoacyl_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11712">
        <property type="entry name" value="PTHR11712"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02801">
        <property type="entry name" value="Ketoacyl-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00825">
        <property type="entry name" value="PKS_KS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PKS_KS" evidence="3">
        <location>
            <begin position="4"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PJN06334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="363" mass="37805" checksum="D41EB9F7E91FEC32" modified="2018-04-25" version="1">MRKVAGRAALPARTAACVALRAVRDSGLTRDQLADGTALIVAGSNLALAHQAGTVLGHARSPGRLRASYALTHLDVDVVGTVSELTGIHGEGWTLGGASASGTLALVQAVRTIAAGWAERVLVVAPAAELSPVEAESFRRTGAMAHERFRDEPARMCRPFDRDRQGFVRGEAAAAVLLEPAGAARERGADVLAEITGHGQRLDARRGTEPDAEGQAAAMRAALATAGITPDEIDYVNAHGTGSVLGDETEAASLHKVFGDRTTYRVNSTKPLTGHCLTAAGLVEAVAAIAQLRAGAVHPNPNLEHPAAGLPLAGRTAERRPLRTALSNSFAFGGINASVVIRSIRVSSPEKPCNSPQQLRRRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JHY4</accession>
    <name>A0A2M9JHY4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CG723_39605</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CB01635</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000031">
        <property type="protein sequence ID" value="PJN06367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN06367">
        <property type="protein sequence ID" value="PJN06367"/>
        <property type="gene ID" value="CG723_39605"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="118"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="151"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="177"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="240"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="272"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="107"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PJN06367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="308" mass="32661" checksum="1BB9E3E3C807281C" modified="2018-04-25" version="1">MSISHAPPDPDVVAKSAAPDAVPADSDAPSDAPSHVDSVGSPELVRLVPSSTRRTRVPRWLRRTSGPVLLLILWQLLSSTGVLTADVLASPGTIARVAGDLVSDGSLPNAMGVSLQRVAIGLLFGVVVGTGLALVSGLFRVGEDLVDASVQMLRTVPFVGLIPLFIIWFGIGEAPKIAIITLGVSFPLYLNVYAGIRGVDAQLIEAGESLGLSRWGLVRHVVLPGALPGAMTGLRYSLGISWLALVFAEQINADAGIGFLMVQARDFLRTDVIVVCLIVYAFLGLLADFVVRTLERLLLQWRPTFTGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JI15</accession>
    <name>A0A2M9JI15_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Neutral metalloproteinase</fullName>
            <ecNumber evidence="8">3.4.24.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CG723_38970</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">CB01635</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Extracellular zinc metalloprotease.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the peptidase M4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.-" evidence="8"/>
    <dbReference type="EMBL" id="NNBL01000029">
        <property type="protein sequence ID" value="PJN06525.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN06525">
        <property type="protein sequence ID" value="PJN06525"/>
        <property type="gene ID" value="CG723_38970"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011096">
        <property type="entry name" value="FTP_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023612">
        <property type="entry name" value="Peptidase_M4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027268">
        <property type="entry name" value="Peptidase_M4/M1_CTD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001570">
        <property type="entry name" value="Peptidase_M4_C_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013856">
        <property type="entry name" value="Peptidase_M4_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07504">
        <property type="entry name" value="FTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01447">
        <property type="entry name" value="Peptidase_M4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02868">
        <property type="entry name" value="Peptidase_M4_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00730">
        <property type="entry name" value="THERMOLYSIN"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 8" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="2 8" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0964">Secreted</keyword>
    <keyword evidence="3 8" id="KW-0732">Signal</keyword>
    <keyword evidence="5 8" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5023042212" description="Neutral metalloproteinase" evidence="8">
        <location>
            <begin position="38"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="domain" description="FTP" evidence="11">
        <location>
            <begin position="82"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M4" evidence="9">
        <location>
            <begin position="202"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M4_C" evidence="10">
        <location>
            <begin position="352"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="active site" evidence="7">
        <location>
            <position position="342"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="7">
        <location>
            <position position="429"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR623612-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU366073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF07504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PJN06525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="527" mass="55071" checksum="53353888051F00A9" modified="2018-04-25" version="1">MTPHISRFTKKRSTLAIATAVAAGALLTAGMTTGASAQPVADATPGAAPMKLSGAARAGLLQDANAKKAETAAELNLDSKEKLVVRDVVKDRDGATHTRYERTYDGLPVLGGDLVVHESKAGRSEGVTRATSKRIAVSTASASLKAAPEGARKVVWAASGTPRLAYEKVVTGTQKDGTPRKLHVVTDAATGKKIFEWDAIHTGAGESQYSGGVTVGSTKSGSSYALTDAERGGHSTYDLKHGSSGKGTLFTDADDKWGDGTTNDAATAAVDAAYGAQVTWDYYKDVQGRSGINGDGKGAYSRVHYGNAYVNAFWDDSCFCMTYGDGEGNKKPLTSIDVAGHEMSHGVTAATAGLIYSGESGGLNEATSDIFGTAVEFHANNPKDVGDYLIGEKIDINGDGSPLRYMDKPSKDGASLDNWKAGAGNVDVHYSSGIANHFFYLLSEGSGKKEINGVSYDSPTADGQPAAGIGRDKAEKIWFKALTSYFTTNTDYANARKGTLSAASDLYGADSAEYKAVDRAWAAVNVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JI87</accession>
    <name>A0A2M9JI87_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Peptide methionine sulfoxide reductase MsrA</fullName>
            <shortName evidence="4">Protein-methionine-S-oxide reductase</shortName>
            <ecNumber evidence="4">1.8.4.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Peptide-methionine (S)-S-oxide reductase</fullName>
            <shortName evidence="4">Peptide Met(O) reductase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4 6" type="primary">msrA</name>
        <name evidence="6" type="ORF">CG723_38540</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CB01635</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 4">
            <text>[thioredoxin]-disulfide + H2O + L-methionine = [thioredoxin]-dithiol + L-methionine (S)-S-oxide</text>
            <dbReference type="Rhea" id="RHEA:19993"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:58772"/>
            <dbReference type="EC" id="1.8.4.11"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 4">
            <text>[thioredoxin]-disulfide + H2O + L-methionyl-[protein] = [thioredoxin]-dithiol + L-methionyl-(S)-S-oxide-[protein]</text>
            <dbReference type="Rhea" id="RHEA:14217"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="Rhea" id="RHEA-COMP:12313"/>
            <dbReference type="Rhea" id="RHEA-COMP:12315"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16044"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:44120"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="EC" id="1.8.4.11"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the MsrA Met sulfoxide reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.8.4.11" evidence="4"/>
    <dbReference type="EMBL" id="NNBL01000028">
        <property type="protein sequence ID" value="PJN06599.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN06599">
        <property type="protein sequence ID" value="PJN06599"/>
        <property type="gene ID" value="CG723_38540"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033744">
        <property type="term" value="F:L-methionine:thioredoxin-disulfide S-oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008113">
        <property type="term" value="F:peptide-methionine (S)-S-oxide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1060.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01401">
        <property type="entry name" value="MsrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002569">
        <property type="entry name" value="Met_Sox_Rdtase_MsrA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036509">
        <property type="entry name" value="Met_Sox_Rdtase_MsrA_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01625">
        <property type="entry name" value="PMSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55068">
        <property type="entry name" value="SSF55068"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00401">
        <property type="entry name" value="msrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PMSR" evidence="5">
        <location>
            <begin position="8"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="active site" evidence="4">
        <location>
            <position position="14"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01625"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PJN06599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="170" mass="19071" checksum="208822046AE78E2B" modified="2018-04-25" version="1">MAAQTQRAVLAGGCFWGMEDLIRRLPGVTATRVGYTGGDVPNATYRDHGTHAEAIEILFDPEGTDFRAILELFFQIHDPSTKNRQGNDIGLSYRSAIYYVDDEQKRIAEDTIADVDASGLWPGKVVTEVEPVGPFWEAEPEHQDYLQRYPDGYTCHFPRPGWRLPARAEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JIU3</accession>
    <name>A0A2M9JIU3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NAD(P)-dependent oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_37585</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000026">
        <property type="protein sequence ID" value="PJN06788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN06788">
        <property type="protein sequence ID" value="PJN06788"/>
        <property type="gene ID" value="CG723_37585"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008030">
        <property type="entry name" value="NmrA-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05368">
        <property type="entry name" value="NmrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NmrA" evidence="1">
        <location>
            <begin position="3"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN06788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="285" mass="29086" checksum="F066A71E1AA8D785" modified="2018-04-25" version="1">MSIVVTGATGRLGRLVIDGLLAAGVPAESIAAVVRDKDKAAGLAARGVELRIADYSAPGTLAGAFAAGDRVLLISGSEVGQRVAQHQAVIDAAKGAGVALLAYTGVLGGPEADFDLAAEHKVTEQAILDSGLPYTFLRNGWYHENYTENLAPVLEHGAVTASAGEGRVASASRADYAAAAVAVLTGEGHENQAYELSGDVAWSLAEYAAELSKQTGRTIAYNSVTPEQNREILLGAGLPAPFADILVGVDTAIEQGLLATTTGDLSRLTGRPTTPLADAIKAALA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JJF5</accession>
    <name>A0A2M9JJF5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ABC transporter substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_36550</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000024">
        <property type="protein sequence ID" value="PJN06994.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN06994">
        <property type="protein sequence ID" value="PJN06994"/>
        <property type="gene ID" value="CG723_36550"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006059">
        <property type="entry name" value="SBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01547">
        <property type="entry name" value="SBP_bac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014786650" evidence="1">
        <location>
            <begin position="28"/>
            <end position="432"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN06994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="432" mass="47958" checksum="6ABDE160A1BE6C80" modified="2018-04-25" version="1">MSPLPTGSSRPSRRRLLTGVGALGAGAALSGCVTSVRSNVSSGGDVTLQSNLSAPQAKTALQKVVDGFNQRGGASASLNTVASETFRTQLPTYLTSANPPDLYTWYPGSVADAYARRDLLLSLDDVWQSPDLSRYSKALKSLCTSRAGHKVFVPTSYYWWGFFYRKSNFRKWGVDEPRTWDDFLDLCETLQRKKVTPIGLGAGSGTAWVASSWFDYLNIRINGAQYHRDLLAGRHRFDDTEVRRVFDRWDEARPFIDKRGTALAFQDATTELLQGRTGMMLIGTFFADSVPKDQLDDIDFFRFPEIDPKVPMAEEAPTDGYFAGARTPRERQTKEFLRYLATAEAQETYLKSSSGTALPTHPDAKDSGTALVKKGRALVESAAEVTQFFNRDSSDQLSPTADTALIRYLSEPDRVASTLTTWQRDAEKIWGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JKI2</accession>
    <name>A0A2M9JKI2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_34545</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000021">
        <property type="protein sequence ID" value="PJN07372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN07372">
        <property type="protein sequence ID" value="PJN07372"/>
        <property type="gene ID" value="CG723_34545"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN07372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="297" mass="31284" checksum="97BC17A1865B4B6B" modified="2018-04-25" version="1">MTDHPAEHAAWGEAEPSEAPAAGAPVTPADAADAARLVAFGLQPKLQPARDQEYAELLRRYREDPPFARLADAVAAGLGLVVLEVSTRAGMAVTAAEDSVFAVRMGDYARRTSADGSDRFLHGLAHLAVAAMAFPRPEDLADDGYIGRVTVNGVDAFVRQACRRLEERAEERGENTDPASDAPGLEAAWRIWARRSSTGATKDARRLAGSTTGIVAKAVAFLTDSGFLQRTGDDSGGTYRTTARYQLQVRDLAGTAALSELADLGIVPVTDGSASLLPPADEDDGELVADAGLPFHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JKX8</accession>
    <name>A0A2M9JKX8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_34060</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal stress protein A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000020">
        <property type="protein sequence ID" value="PJN07512.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN07512">
        <property type="protein sequence ID" value="PJN07512"/>
        <property type="gene ID" value="CG723_34060"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006015">
        <property type="entry name" value="Universal_stress_UspA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006016">
        <property type="entry name" value="UspA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00582">
        <property type="entry name" value="Usp"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01438">
        <property type="entry name" value="UNVRSLSTRESS"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Usp" evidence="2">
        <location>
            <begin position="9"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="domain" description="Usp" evidence="2">
        <location>
            <begin position="157"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN07512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="304" mass="31805" checksum="1E11DC531E4DD0B6" modified="2018-04-25" version="1">MSTPRPLPVVAAVDGSEDSLRALEWALTEAGRRGAPVRIAHVRQYAPWTQPGVLVSGPPEPAGDPVVDEVRASLTGRGGLPPVEYVTLEGAPAAALPELGAEAQLLVLGSRGRGGFASLLLGSNGVAVARDAACPVVVVPRPGRAVHGDDDLPPGPRVVVGVEVDEPDDTLLAFAFEEADRGGARLQVIAVFPWPVLAWTTFGDFTPTTVDQEAAERETLTLVNAAVAPFRKMHPDVEVDLYVAPGDAAGHLVENSREADLVVVGRHRRRLTRPAPMLGTVTMAVLLHAASPVAVVPPVLEDAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JL27</accession>
    <name>A0A2M9JL27_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_32965</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000019">
        <property type="protein sequence ID" value="PJN07579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN07579">
        <property type="protein sequence ID" value="PJN07579"/>
        <property type="gene ID" value="CG723_32965"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020246">
        <property type="entry name" value="Uncharacterised_SCO3924"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17260">
        <property type="entry name" value="DUF5326"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="39"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN07579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="70" mass="7669" checksum="57A31EF3976314A8" modified="2018-04-25" version="1">MREIFAGMPWWVKWVAVPVIALVVFGGLIASVVGFVIGLLFKVLVFVALVGGLIYVVRKFITGSSSRSDW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JL40</accession>
    <name>A0A2M9JL40_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CG723_33020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000019">
        <property type="protein sequence ID" value="PJN07589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN07589">
        <property type="protein sequence ID" value="PJN07589"/>
        <property type="gene ID" value="CG723_33020"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005624">
        <property type="entry name" value="PduO/GlcC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038084">
        <property type="entry name" value="PduO/GlcC-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03928">
        <property type="entry name" value="Haem_degrading"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143744">
        <property type="entry name" value="SSF143744"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PJN07589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="140" mass="14339" checksum="AE618425BC9DD6F3" modified="2018-04-25" version="1">MSTTTAVAPLTIQDAEILVTAARRAAESAGVNVSVTVLDAGGHLLAFRRDDRAVLISGETSTRKAYTALQLNAPTADLVELVKPDGPFHSLPTALDRPLLFIAGGIPVHRDGHLIGAVGVGGGAPEQDHGFATAAVAELV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JLP1</accession>
    <name>A0A2M9JLP1_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HTH cro/C1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_32440</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000018">
        <property type="protein sequence ID" value="PJN07778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN07778">
        <property type="protein sequence ID" value="PJN07778"/>
        <property type="gene ID" value="CG723_32440"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013096">
        <property type="entry name" value="Cupin_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07883">
        <property type="entry name" value="Cupin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="14"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN07778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="191" mass="21029" checksum="2870DCB4A2157CF5" modified="2018-04-25" version="1">MDEHKETLRVGAAVRRRRRGQELTLATVAERSGLSVPFLSQVENERARPSRRSLEKVADALGTTAVELLAAADPAHTVDLVRADDTTVVEEASPDSVVRSLVRGHHQLHAEEFIGDHDPGREFQLRNDVLMYVTEGAVEVEAEGRAYRLGRGDTLYLTGGVRHRWRATGADARVLVVAVAEHIEALDEPGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-09-29" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JLR0</accession>
    <name>A0A2M9JLR0_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ferredoxin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CG723_32620</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CB01635</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000018">
        <property type="protein sequence ID" value="PJN07810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN07810">
        <property type="protein sequence ID" value="PJN07810"/>
        <property type="gene ID" value="CG723_32620"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001080">
        <property type="entry name" value="3Fe4S_ferredoxin"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00352">
        <property type="entry name" value="3FE4SFRDOXIN"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0249">Electron transport</keyword>
    <keyword evidence="2 4" id="KW-0408">Iron</keyword>
    <keyword evidence="3 4" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="1 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU368020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PJN07810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="104" mass="11049" checksum="5C38613C5352EF71" modified="2018-04-25" version="1">MSVQQEAGSGIDSGVALEVWIDQDLCTGDGICAQYAPEVFELDIDGLAYVKGAEDELLQAQGATTPVPLPLLNDVVDSAKECPGDCIHVRRVSDRVEVYGPDAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JLY6</accession>
    <name>A0A2M9JLY6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CG723_31240</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000017">
        <property type="protein sequence ID" value="PJN07873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN07873">
        <property type="protein sequence ID" value="PJN07873"/>
        <property type="gene ID" value="CG723_31240"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00207">
        <property type="entry name" value="fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036010">
        <property type="entry name" value="2Fe-2S_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001041">
        <property type="entry name" value="2Fe-2S_ferredoxin-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006058">
        <property type="entry name" value="2Fe2S_fd_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000951">
        <property type="entry name" value="Ph_dOase_redase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00111">
        <property type="entry name" value="Fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00409">
        <property type="entry name" value="PHDIOXRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="SSF52343"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54292">
        <property type="entry name" value="SSF54292"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="SSF63380"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00197">
        <property type="entry name" value="2FE2S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51085">
        <property type="entry name" value="2FE2S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding FR-type" evidence="6">
        <location>
            <begin position="4"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="domain" description="2Fe-2S ferredoxin-type" evidence="5">
        <location>
            <begin position="232"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PJN07873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="319" mass="33781" checksum="E9E2F62870F61A12" modified="2018-04-25" version="1">MNTEIELELVVAAATEPAADVRLLELRSPDGAELPAWSAGAHIDLLLDDGLVRQYSLCGDPDDRSSWQVAVLREPESRGGSAHVHDKLGVGDPIKARGPRNNFELEPAAAYVFVAGGIGITPILPMLASADAAGADWRLYYGGRTRGSMAFVDDVVARHGDRVVVRPQDETGLLDLAGIVAGRPDGAPIYCCGPAPLLDALECVCTPLPSGTLRTERFTALEADSDAVFEGFEVELTDSGQVLQVPADKTILDVMEEAGIEVLSSCREGTCGTCETGVLSGTIDHRDVLLTPDERAANDVMFVCVSRAAPGCSRLALER</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JM86</accession>
    <name>A0A2M9JM86_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Deaminase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_30260</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000016">
        <property type="protein sequence ID" value="PJN07986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN07986">
        <property type="protein sequence ID" value="PJN07986"/>
        <property type="gene ID" value="CG723_30260"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008703">
        <property type="term" value="F:5-amino-6-(5-phosphoribosylamino)uracil reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009231">
        <property type="term" value="P:riboflavin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.430.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024072">
        <property type="entry name" value="DHFR-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002734">
        <property type="entry name" value="RibDG_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01872">
        <property type="entry name" value="RibD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53597">
        <property type="entry name" value="SSF53597"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RibD_C" evidence="1">
        <location>
            <begin position="7"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN07986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="192" mass="21031" checksum="E3EF187674BB1EBC" modified="2018-04-25" version="1">MTAAYTFDVFSSLDGFGAAGGNWTGYWGKQGPELLEHRLAVYDDEQRMVFGANTYRAFAQMLASSTEESEVRDPWVTRMRNLPATVVSTTLEGPLDWPDASVAAGDAVDVVARLKKESNVPLRSHGSLSMNRALMAAGLVDRVQVTLFPVITGQTGLDPIFRGAADFDLELIEHRTLDGGIQELIYRPTLHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JMK5</accession>
    <name>A0A2M9JMK5_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF1801 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_30650</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000016">
        <property type="protein sequence ID" value="PJN08109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08109">
        <property type="protein sequence ID" value="PJN08109"/>
        <property type="gene ID" value="CG723_30650"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014922">
        <property type="entry name" value="DUF1801"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08818">
        <property type="entry name" value="DUF1801"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF1801" evidence="1">
        <location>
            <begin position="20"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08818"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN08109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="121" mass="13533" checksum="116EDF923578E616" modified="2018-04-25" version="1">MVQSSAEDVDGYLDEVAEGRREALTRLRELCCTELKGFEEVMAYGMPAYVRDGAAEIAFASQKQYVSFYLLRSDVREAFTERLAAQDMGKGCLRFRKPESIDFDLVRDLLRATAAASGKSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JML6</accession>
    <name>A0A2M9JML6_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Fumarate hydratase class I</fullName>
            <ecNumber evidence="10">4.2.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CG723_29370</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">CB01635</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Catalyzes the reversible hydration of fumarate to (S)-malate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>(S)-malate = fumarate + H2O</text>
            <dbReference type="Rhea" id="RHEA:12460"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15589"/>
            <dbReference type="ChEBI" id="CHEBI:29806"/>
            <dbReference type="EC" id="4.2.1.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 10">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="4 10">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the class-I fumarase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.2" evidence="10"/>
    <dbReference type="EMBL" id="NNBL01000015">
        <property type="protein sequence ID" value="PJN08119.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08119">
        <property type="protein sequence ID" value="PJN08119"/>
        <property type="gene ID" value="CG723_29370"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004333">
        <property type="term" value="F:fumarate hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006091">
        <property type="term" value="P:generation of precursor metabolites and energy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004646">
        <property type="entry name" value="Fe-S_hydro-lyase_TtdA-typ_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004647">
        <property type="entry name" value="Fe-S_hydro-lyase_TtdB-typ_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036660">
        <property type="entry name" value="Fe-S_hydroAse_TtdB_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011167">
        <property type="entry name" value="Fe_dep_fumarate_hydratase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020557">
        <property type="entry name" value="Fumarate_lyase_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05681">
        <property type="entry name" value="Fumerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05683">
        <property type="entry name" value="Fumerase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001394">
        <property type="entry name" value="Fe_dep_fumar_hy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117457">
        <property type="entry name" value="SSF117457"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00722">
        <property type="entry name" value="ttdA_fumA_fumB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00723">
        <property type="entry name" value="ttdB_fumA_fumB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00163">
        <property type="entry name" value="FUMARATE_LYASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="7 10" id="KW-0408">Iron</keyword>
    <keyword evidence="8 10" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="9 10" id="KW-0456">Lyase</keyword>
    <keyword evidence="6 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fumerase" evidence="11">
        <location>
            <begin position="51"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="domain" description="Fumerase_C" evidence="12">
        <location>
            <begin position="334"/>
            <end position="541"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR001394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF05681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF05683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PJN08119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="559" mass="60556" checksum="DED7D6BCCCD00CB5" modified="2018-04-25" version="1">MGEMPEFAYTDLLPQGEDTTPYRLVTTEGVSTAEGPDGRTFLKVEPEALRKLAEEAIHDIQHYLRPAHLAQLRRIIDDPEASGNDKFVALDLLKNANIAAAGVLPMCQDTGTAIVMGKRGQNVLTEGGDEAALSRGIYDAYKNLNLRYSQMAPLNMWDEKNTGSNLPAQIELYATDGGAYKFLIMAKGGGSANKSFLYQETKAVLNEGSMMKFLEEKIRSLGTAACPPYHLAIVVGGTSAEYALKTAKYASAHYLDEIPAEGSELGHGFRDKELEEKVFELTQKIGIGAQFGGKYFCHDVRVVRLPRHGASCPVAIAVSCSADRQAVAKITAEGVFLEQLETDPARFLPETTDEHLDESGDVVKIDLNQPMDDILAALTKHPVKTRLSLTGPLVVARDIAHAKIKERLDAGEEMPQYLKDHPVYYAGPAKTPEGYASGSFGPTTAGRMDSYVEQFQAAGGSKVMLAKGNRSQQVTDACDAHGGFYLGSIGGPAARLAQDCIKKVEVVEYEELGMEAVWKIEVEDFPAFVVVDDKGNDFFKDPAPAPTFTSIPVRGPGLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JMT5</accession>
    <name>A0A2M9JMT5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CG723_29660</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CB01635</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000015">
        <property type="protein sequence ID" value="PJN08174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08174">
        <property type="protein sequence ID" value="PJN08174"/>
        <property type="gene ID" value="CG723_29660"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045621">
        <property type="entry name" value="BPD_transp_1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19300">
        <property type="entry name" value="BPD_transp_1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="98"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="131"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="174"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="224"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="275"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="94"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PJN08174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="307" mass="33561" checksum="03E2A1554918E267" modified="2018-04-25" version="1">MGRYVIRRLLQMIPVFFGATLLIFLMVNVMGDPIAGLCGDKQCDPATAAQLEKEFGLDKPVWQQYLTYMGNVFTGDFGTAFNGQKVTELMAAAFPVTIRLTVVAILFEIVIGITLGVVTGLRRGRPVDTTVLLLTLVVISVPTFVTGLLLQLLLGVEWGIIKPAVSTEATFSELIVPGLVLASVSLAYVTRLTRTSIAENRRADYVRTAIAKGLPRRRVIVRHLLRNSLIPVVTFIGTDIGALMGGAIVTERIFNIHGVGYQLYQGILRQNTQTVVGFVTVLVLVFLAANLIVDLLYAVLDPRIRYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JMV1</accession>
    <name>A0A2M9JMV1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">SAM-dependent methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_29470</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000015">
        <property type="protein sequence ID" value="PJN08137.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08137">
        <property type="protein sequence ID" value="PJN08137"/>
        <property type="gene ID" value="CG723_29470"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044260">
        <property type="term" value="P:cellular macromolecule metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043412">
        <property type="term" value="P:macromolecule modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006807">
        <property type="term" value="P:nitrogen compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044238">
        <property type="term" value="P:primary metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002052">
        <property type="entry name" value="DNA_methylase_N6_adenine_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00092">
        <property type="entry name" value="N6_MTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1242"/>
            <end position="1264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1250"/>
            <end position="1264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN08137.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="1264" mass="142510" checksum="60F7080A3E860015" modified="2018-04-25" version="1">MEADVTVETAGTARLDKEALVKDLKRLVLDLEDDLRVRSETVDEFRAPLEEEYRQAKEAKRIAAPYAAWRDERVTQAAAAWVLACVFVRFCEDNGLIEEPYIAGPGERLAEAEARHDQFFREHPQLNDRDWLIESFDHLAGTNAAAAGLFDKNHNPLWSITPGYDSATKLLAFWRRWGAAGEIRYDFTDPEWNTRFLGDLYQDLSEHARKTYALLQTPEFVEEFILDLTLEPAIEEFGLNAVREDPLDPKGEPLRGLRTIDPACGSGHFLLGIFHRLLDKWRIAEPGTADWTLVRRSLESVHGCDKNPFAASIARFRLLVAAMKAAGETRLDRMRPFPINVAVGDSLLHGRGATGIQTEIELDTLFADAVVGTEGEDGDGETYAYSTEDVWEYAKRADLLGRGSYHVVVGNPPYITVKDKQENENYRAAYKDVCAGTYALSVPFAARLFDLAVRGPGGRLGGGGFVGQITANSFMKREFGKKLIEVFFRNRAELSHVIDTSGAYIPGHGTPTVILVGRNRIPSPGRTVRAVLGVRGEPGQPPKGKEAEGYVWQAIVEQVGRPGSESDWVSVENEVARTFSSHPWAVSGGGAGALQELIESKAVAVLRERVASIGFGAVTRADDAYVLGRGALRRAGVPDAMRRPMVDGETTRDWRIVSPTEILWPYDEKKPDRARSNDAVLKLAWPNRLILRERVAYGKTQLERELEWFEYSMFFSHRYADLTLAFACVSTHNHFVLGRGKKVYNRHAPLIQMREGADEDAHLELLGVLNSSTACFWLKQVSQDKGNRGGERSTGRYAWESFYEFTGTKLQEFPLPGELPLELGRQMDTLARELADQEPPAICSRVTPDRTLLDAAESEHARIWRQMIALQEELDWRVYGQYGLLSGAELARTTVGEAIPDLPEVDLGERAFELAIAPRAATDEAVGQWFRRHGSTPVTEIPPHWPEWYRKIVQARIDIITSRPKDIGLIERPECKRRWSAVSWEKKERGALRAWLLDRCESDELWYELRDGMKQPRSMTVNYLADQLSSDADFVSVAALYASDHLGMPDLPLAQVLTEVIADEHVPYLAALRYKDAGLRIRAQWEEVWEKQREEDRAGERLDIDPPSKYKTSDFLRTSYWSNRGKLDVPKERFISYPDASPDGDPTLMLGWAGWDHKDQAQVLSQLIDARTKRDGWSTERIVPLLAGLREVMPWVKQWHGEPDAEWDDEVPAEVLEADYEALLRRHGVGEAQLEAWRPVTKPRGRKAVAPKRKPVEQVELGEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JNC4</accession>
    <name>A0A2M9JNC4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Aldose epimerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_28695</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000014">
        <property type="protein sequence ID" value="PJN08366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08366">
        <property type="protein sequence ID" value="PJN08366"/>
        <property type="gene ID" value="CG723_28695"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008183">
        <property type="entry name" value="Aldose_1/G6P_1-epimerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014718">
        <property type="entry name" value="GH-type_carb-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01263">
        <property type="entry name" value="Aldose_epim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="SSF74650"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="168"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN08366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="264" mass="29430" checksum="EA6A609701385DF2" modified="2018-04-25" version="1">MTTQETTLTAGDAEVTVQPGNGCRVSSLRIGGTELLRQGERYGCFPMVPWCGRIRDGRFRDGGQTYQMPLNSPPHAIHGFARDAEWTTARASADEAVFTYDLAEPWPWTGRVTQMVRLAEDSLTLTLGIETYGDSFPAQAGWHPWFNRTLDGSADGARVEFSPAWQEERGDDHLPTGKRIDRTDGPWDDCFGMPDGVDVTLTWPQQFEVRIASREQWVVVYDEQEAAACVEPQTGPPDGLNTLPRLVTPVEPLEASTTWTWRAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JNG4</accession>
    <name>A0A2M9JNG4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glucoamylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_28925</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000014">
        <property type="protein sequence ID" value="PJN08404.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08404">
        <property type="protein sequence ID" value="PJN08404"/>
        <property type="gene ID" value="CG723_28925"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011613">
        <property type="entry name" value="GH15-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045582">
        <property type="entry name" value="Trehalase-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19291">
        <property type="entry name" value="DUF5911"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00723">
        <property type="entry name" value="Glyco_hydro_15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="SSF48208"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF5911" evidence="2">
        <location>
            <begin position="5"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_hydro_15" evidence="1">
        <location>
            <begin position="230"/>
            <end position="548"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF19291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN08404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="609" mass="68036" checksum="83DD70ED606794D6" modified="2018-04-25" version="1">MRRYPPIADHGMVGDLQTAALVSSDGVVDWFCAPRFDSPSLFASLLDHDRGGHFAITVEGPDVTTRQLYLADTAVLITRFLTPHGVGEVVDFMPLDRPETATDRHRLIRVMRVTRGRIRFALTCSPRFDYARAVHRLTLDEGAAHFAGPGTDAHLQTLGPVELERDGEAVRAVVELEQEQMAAAVLTVYATGGEAPPPPTRERLKEEFDATCAFWYRWISRSRYRGRWQQTVHRSAITLKLLTYAPTGAPVAAATAGLPEQLGGERNWDYRYTWVRDASLSLHALFGLGFTEEAHAFRRWLAGRLLEGPDRTVTGEPLQIMYRIDGDPHLAEETLDHLEGYRGSAPVRIGNGAACQLQLDIYGEAVYALTHTDDLAHVMGYDGWLGVSDVLDWLAQNWDRPDEGIWETRGGRKDFTYSRLMCWTAFDRGIRVAQELARPADLTAWTAARDTILRQIMDRGWSEKRRAFVQHYGSDVLDASLLLMPGVRFVTPRDPRWLSTLDAMDTELVSDSLVYRYDPAASPDGLRGSEGTFSLCSFFYVDALARAGRLGQARYAFDKMLTYANHVGLFSEEIGPTGEQLGNFPQAFTHLALITAALALDEELDRAGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JNU0</accession>
    <name>A0A2M9JNU0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Non-ribosomal peptide synthetase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CG723_27545</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CB01635</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Antibiotic biosynthesis.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000013">
        <property type="protein sequence ID" value="PJN08536.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08536">
        <property type="protein sequence ID" value="PJN08536"/>
        <property type="gene ID" value="CG723_27545"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00223">
        <property type="reaction ID" value="UER00999"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043604">
        <property type="term" value="P:amide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017000">
        <property type="term" value="P:antibiotic biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008610">
        <property type="term" value="P:lipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901362">
        <property type="term" value="P:organic cyclic compound biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901566">
        <property type="term" value="P:organonitrogen compound biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030639">
        <property type="term" value="P:polyketide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="CDD" id="cd05931">
        <property type="entry name" value="FAAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010071">
        <property type="entry name" value="AA_adenyl_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001242">
        <property type="entry name" value="Condensatn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040097">
        <property type="entry name" value="FAAL/FAAC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00668">
        <property type="entry name" value="Condensation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="SSF47336"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01733">
        <property type="entry name" value="AA-adenyl-dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="5">
        <location>
            <begin position="592"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="5">
        <location>
            <begin position="1637"/>
            <end position="1713"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="4">
        <location>
            <position position="626"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="4">
        <location>
            <position position="1672"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PJN08536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="1745" mass="184794" checksum="B5DEBC98B4F576B7" modified="2018-04-25" version="1">MHTHVRPVGGTLVDILRDRADATPHRTALEFIRDDGSEHAVGYAALDRRVRAVAAALTERGLRGERVLLLFPPGENYVTAFLGCLYAGAVAVPVYVPTGKRGLSAVLATGADAGAVLALSSREVTDAITASYPELTTSGLIQWLVTEDIADAAADDWPGAGPAPADLAFLQYTSGSTGTPKGVMVRHDNLVHNSASISTALGVGPDSRGVSWLPPYHDMGLIGGILQPLYAGFPCTLISPMAFVRSPYRWLDAISRHRATVSAAPDFAYGECVRRIPEDKRAELDLSSWQHAMVGAEPVRPATLDAFARAFADSGFDRSAFHPCYGLAEATLFVTGGAPERGEPRVLRADRRELELGQAVSATAGKENKENAAVLTGCGRSRSEDVVVVVDPAEGRACPPGGTGEVWVSGPTVTAGYWGRPELTDEVFRATLESHPGRHFLRTGDLGFTLGDELFVTGRAKDLLVVRGRNHYPQDIEQSAEHAHPLLQPTRAAVFSHDDGAEERAVLVHEVVRGFDPERAPEVITAVRKAVTAEHGLSLHEVVLVRPGAIPRTTSGKVRRSTCRERWLDGTLQPIATGGADTAPDAGGGDMPPVSRAVAEVVALELDVPAEQLPPGVPLVVLDLDSLRAVRLAEAVRERFGLRVSPAELLDGLTLAGLSALVDAVDDVAEAHVGADDTEAADGPASRAQEWMWLLDAMGGGAAYHVAGGIDLHGPVDPELLRASLEDLVARHPALHSGFTSDPEGTLRRTPLAPRSFELPVVEPSADRDARAVAAALAREPFDLAAGPLLRAVLVRAGAREWTLAVAAHHIAVDGWSLGLLLRELGICYRDRLAGRSPSRTVVTVPAPKSAGDDGEAAAFWQETLAGAQAVSLPLDPAPHPSPFQGSALPFTLPAPVVARLKRYGAKRRSTLFMVILTGLSAVLSRWTGQQDLVVGAVTAGRHRPGSGDLVGLFVNTLPLRVEASGDPAFGELLSRVRSSCLAAYRHQDLPLEEIVRLTGADRADGRAPLVRVALALQNLPVAPWQSGEVRAEPFELPSPGAQFELSLHLTEESDGSLTGHAVHASDLISAPSARRILQALTLALEAVPGPPGAAATDLPMLTSHELDRVVGEFSGSDTPLDDGLVHAGFERQARLTPNAPAVVWDGGALSYAQLDARANQLARRLRSLGAAPDQVVAVHLPRSPELVVALLAVVKAGGAYLPLDPDHPRARLALQLADVTPSLLVTSRDAAHGGAGELAAGSPGLTLVEIDDPALAELPDGPLDEVARPDNLLYVLHTSGTTGTPKGVMNQHAGVANRMAWMQAKYPLVAGERVLHKTPVGFDVSGWEIWWPLGHGATIVLARPGGHQDPGYLVRSVVDHAVTTCHFVPSMLRVFLDETTAATAGGTLRRVVCSGEALPPDVAARFHRLLPGVELHNLYGPTEAAIDVTAEQVEPGSTDRPRLPIGRPVPGVRLYVLDERGNPAPVGVPGELHIGGPQVARGYFGRPSLTAAAFVPDPFGSGGRLYRTGDRACWTEDGTLDYLGRTDHQVKIRGQRVEPGESEAVLARHPAVGDAVVVARRQGGETYLAAYLVAAAGAEQPDPAQLREHLSLSLPPAMIPSAYTWLDALPVGANGKLDRDALPEPDQNLAGGEHVAPRDAAEQRVAEVWCEVLGLEEVSVTADFFALGGHSLQATRIALRLREAFGAEFSVADLLTGVPTVEQTARLLTQRQVAESDPEELARLLDQLSGLSDDEVADLLQQQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JPA3</accession>
    <name>A0A2M9JPA3_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">FO synthase</fullName>
            <ecNumber evidence="9">2.5.1.147</ecNumber>
            <ecNumber evidence="8">4.3.1.32</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="primary">fbiC</name>
        <name evidence="19" type="ORF">CG723_26750</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">CB01635</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Catalyzes the radical-mediated synthesis of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (FO) from 5-amino-6-(D-ribitylamino)uracil and L-tyrosine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>5-amino-5-(4-hydroxybenzyl)-6-(D-ribitylimino)-5,6-dihydrouracil + S-adenosyl-L-methionine = 5'-deoxyadenosine + 7,8-didemethyl-8-hydroxy-5-deazariboflavin + H(+) + L-methionine + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:55204"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17319"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:59904"/>
            <dbReference type="ChEBI" id="CHEBI:85936"/>
            <dbReference type="EC" id="4.3.1.32"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>5-amino-6-(D-ribitylamino)uracil + L-tyrosine + S-adenosyl-L-methionine = 2-iminoacetate + 5'-deoxyadenosine + 5-amino-5-(4-hydroxybenzyl)-6-(D-ribitylimino)-5,6-dihydrouracil + H(+) + L-methionine</text>
            <dbReference type="Rhea" id="RHEA:55200"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15934"/>
            <dbReference type="ChEBI" id="CHEBI:17319"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:58315"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:77846"/>
            <dbReference type="ChEBI" id="CHEBI:85936"/>
            <dbReference type="EC" id="2.5.1.147"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="5">Cofactor biosynthesis; coenzyme F0 biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">In the C-terminal section; belongs to the radical SAM superfamily. CofH family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">In the N-terminal section; belongs to the radical SAM superfamily. CofG family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.147" evidence="9"/>
    <dbReference type="EC" id="4.3.1.32" evidence="8"/>
    <dbReference type="EMBL" id="NNBL01000012">
        <property type="protein sequence ID" value="PJN08698.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08698">
        <property type="protein sequence ID" value="PJN08698"/>
        <property type="gene ID" value="CG723_26750"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00072"/>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044689">
        <property type="term" value="F:7,8-didemethyl-8-hydroxy-5-deazariboflavin synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01611">
        <property type="entry name" value="FO_synth_sub1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01612">
        <property type="entry name" value="FO_synth_sub2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019939">
        <property type="entry name" value="CofG_family"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045567">
        <property type="entry name" value="CofH/MnqC-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019940">
        <property type="entry name" value="CofH_family"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaB/NifB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034405">
        <property type="entry name" value="F420"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020050">
        <property type="entry name" value="FO_synthase_su2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43076">
        <property type="entry name" value="PTHR43076"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19288">
        <property type="entry name" value="CofH_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00293">
        <property type="entry name" value="((2_3_4_5-tetrahydroxypentyl)a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00294">
        <property type="entry name" value="7_8-didemethyl-8-hydroxy-5-dea"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00343">
        <property type="entry name" value="aminofutalosine_synthase_(mqnE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03550">
        <property type="entry name" value="F420_cofG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03551">
        <property type="entry name" value="F420_cofH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00423">
        <property type="entry name" value="TIGR00423"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="14" id="KW-0408">Iron</keyword>
    <keyword evidence="15" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="16" id="KW-0456">Lyase</keyword>
    <keyword evidence="13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="domain" description="Radical SAM core" evidence="18">
        <location>
            <begin position="67"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="domain" description="Radical SAM core" evidence="18">
        <location>
            <begin position="526"/>
            <end position="761"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="407"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="828"/>
            <end position="860"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00000403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00003692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00010051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00010826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00012126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00012289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="PJN08698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="860" mass="94065" checksum="EAC9F7BF20CFAFB9" modified="2018-04-25" version="1">MSDPEAVRPTANAMRRALKRSRDGVALDMAEAAVLLQARGDDLRDLTASAARVRDAGLKAAGRPGVITYSKKVFIPLTRLCRDKCHYCTFVTVPGKLRRDGHGMYLSPDEVLDIARRGAEMGCKEALFTLGDRPEDRWPEAREWLDAHGYDDTLAYVRAMAIRVLEETGLLPHLNPGVMTWTDLQRLKPVAPSMGMMLETTATRLWSEPGGPHHGSPDKEPAVRLRVLEDAGRSNVPFTTGVLIGIGESYEERADSLFQLRRIQRSYHGIQEVIVQNFRAKPDTAMRGMPDAELEELAACIAVARHVLGPSARIQAPPNLVDEEYALLIGAGIDDWGGVSPLTPDHVNPERPWPHIDELAAKTGEAGFELRERLTIYPEFIERGEPWLDPRLLPHVGALASADTGLADEGARPEGLPWQEPDEGFTGTGRTDLHRTIDTTGRTSDRRDDFDDVYGDWEALREQAAPGMVPQRIDSDVRAALATAADDPTKLTDGEALALLHADGPALDALCGIADDIRKTVNGDDVTYIVTRNINFTNVCYTGCRFCAFAQRRTDADAYTLSLSQVADRAEQAWDVGAVEVCMQGGIHPDLPGTAYFDIAKAVKERVPGMHVHAFSPMEVVNGATRTGMSIRDWLTAAKEAGLDSIPGTAAEILDDEVRWVLTKGKLPTATWVEVIKTAHELGIRSSSTMMYGHVDQPRHWLGHFRTLAAIQQETGGFTEFVTLPFIHTNAPVYLAGIARPGPTTRDNRAVTAMARVLLHPHIPNIQTSWVKLGTEGAAEMLRSGANDLGGTLMEETISRMAGSSYGSYRSIKDLITIAEEAGRPAKPRTTLYGEVPEERQRAATASDGHLPELLPVLGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JPY8</accession>
    <name>A0A2M9JPY8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">NAD-dependent malic enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CG723_26015</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CB01635</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="3">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="3">Divalent metal cations. Prefers magnesium or manganese.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the malic enzymes family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000011">
        <property type="protein sequence ID" value="PJN08941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08941">
        <property type="protein sequence ID" value="PJN08941"/>
        <property type="gene ID" value="CG723_26015"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004471">
        <property type="term" value="F:malate dehydrogenase (decarboxylating) (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10380">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046346">
        <property type="entry name" value="Aminiacid_DH-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012301">
        <property type="entry name" value="Malic_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037062">
        <property type="entry name" value="Malic_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012302">
        <property type="entry name" value="Malic_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001891">
        <property type="entry name" value="Malic_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00390">
        <property type="entry name" value="malic"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03949">
        <property type="entry name" value="Malic_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000106">
        <property type="entry name" value="ME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01274">
        <property type="entry name" value="malic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00919">
        <property type="entry name" value="Malic_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53223">
        <property type="entry name" value="SSF53223"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="malic" evidence="6">
        <location>
            <begin position="42"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="domain" description="Malic_M" evidence="5">
        <location>
            <begin position="187"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="11"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="2">
        <location>
            <position position="63"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="2">
        <location>
            <position position="118"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="160"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="161"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="186"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008785"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000106-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000106-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM01274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PJN08941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="414" mass="42626" checksum="F1E6D406C5E8179E" modified="2018-04-25" version="1">MAAEIVNPRSDAGSGQASAGPAHTGNESTEEPFDPAFALHRGGKMAVQATVPVRNKDDLSLAYTPGVAKVCSAIAENPELVHDYTWKSSVVAVVTDGTAVLGLGDIGPEASLPVMEGKAILFKQFGGVDAVPIALGTTDTDEIIETVVRLAPSFGGVNLEDISAPRCFEIERRLQERLDIPVFHDDQHGTAVVTLAALKNAAKLSGRTLGELRAVISGAGAAGVAIAKFLLEAGLGDVAVADRKGIVSRDREDLTDVKRELAELTNKANITGSLETALAGADVFIGVSGGTVPEPAVASMAPGAFVFAMANPNPEVHPDVAHKYAAVVATGRSDYPNQINNVLAFPGIFAGALQVRASRITEGMKIAAADALADVVGDDLDAGYVIPSPFDERVAPAVTAAVAAAARAEGVARR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JQ05</accession>
    <name>A0A2M9JQ05_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">1-aminocyclopropane-1-carboxylate deaminase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CG723_26130</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CB01635</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ACC deaminase/D-cysteine desulfhydrase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000011">
        <property type="protein sequence ID" value="PJN08963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08963">
        <property type="protein sequence ID" value="PJN08963"/>
        <property type="gene ID" value="CG723_26130"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901607">
        <property type="term" value="P:alpha-amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027278">
        <property type="entry name" value="ACCD_DCysDesulf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="PLP-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="Trypto_synt_PLP_dependent"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43780">
        <property type="entry name" value="PTHR43780"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006278">
        <property type="entry name" value="ACCD_DCysDesulf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="SSF53686"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PALP" evidence="7">
        <location>
            <begin position="31"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="4">
        <location>
            <position position="85"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="5">
        <location>
            <position position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008639"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR006278-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR006278-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PJN08963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="317" mass="33769" checksum="840D31F49AE092A2" modified="2018-04-25" version="1">MTRLHNEQVTSHSRPRPPLHPRLPSPVEPVADDRFHRHGVRLLLKRDDLIHPDLPGNKWRKLAPNLEAATAAGHGTLLTFGGAYSNHLRATAAAGRLMGLRTIGVVRGQELAGQPLNASLARCADDGMRLHFVDRTTYREKRDPATLARILREVAPPDGDGKTPYVVPEGGSNTEAVRGCAELGQELRGAADAVGVACGTGGTLAGLAAGLGEGQRALGIPVLKGGFLGDEIRTLQEAAFGGPRGDWSLDERFHCGGYGRTTPALLAFAEDFEQRHGVPIERLYVAKLLYGLLTLTEEGAFAPGTRLMAVVTGTPSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JQ08</accession>
    <name>A0A2M9JQ08_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">N-acetylmuramoyl-L-alanine amidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_26125</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000011">
        <property type="protein sequence ID" value="PJN08962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN08962">
        <property type="protein sequence ID" value="PJN08962"/>
        <property type="gene ID" value="CG723_26125"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008745">
        <property type="term" value="F:N-acetylmuramoyl-L-alanine amidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009253">
        <property type="term" value="P:peptidoglycan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06583">
        <property type="entry name" value="PGRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.80.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036505">
        <property type="entry name" value="Amidase/PGRP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002502">
        <property type="entry name" value="Amidase_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01510">
        <property type="entry name" value="Amidase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00644">
        <property type="entry name" value="Ami_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55846">
        <property type="entry name" value="SSF55846"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetylmuramoyl-L-alanine amidase" evidence="1">
        <location>
            <begin position="23"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00644"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN08962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="192" mass="21151" checksum="295C8C53A7C37795" modified="2018-04-25" version="1">MSASSFLDALKREGLTVVEVGDWRHHNRNHKGPWGPVNGVMIHHTVTKGSKQTVDLCQKGHADLPGPLCHGVITKDGRVHLVGYGRANHAGLGDDDVLRAVIAEKALPHDNEANTDGNRHFYGFECENLGDGEDPWPAAQLEAIERAAAAVCRHHGWTERSVIGHLEWQPGKVDPRGFTMASMRGRIRDRLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-05-25" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JQN8</accession>
    <name>A0A2M9JQN8_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">N-acetylmuramic acid 6-phosphate etherase</fullName>
            <shortName evidence="3">MurNAc-6-P etherase</shortName>
            <ecNumber evidence="3">4.2.1.126</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">N-acetylmuramic acid 6-phosphate hydrolase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="3">N-acetylmuramic acid 6-phosphate lyase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3 5" type="primary">murQ</name>
        <name evidence="5" type="ORF">CG723_25040</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CB01635</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6-phosphate and D-lactate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>H2O + N-acetyl-D-muramate 6-phosphate = (R)-lactate + N-acetyl-D-glucosamine 6-phosphate</text>
            <dbReference type="Rhea" id="RHEA:26410"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16004"/>
            <dbReference type="ChEBI" id="CHEBI:57513"/>
            <dbReference type="ChEBI" id="CHEBI:58722"/>
            <dbReference type="EC" id="4.2.1.126"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-sugar metabolism; N-acetylmuramate degradation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="miscellaneous">
        <text evidence="3">A lyase-type mechanism (elimination/hydration) is suggested for the cleavage of the lactyl ether bond of MurNAc 6-phosphate, with the formation of an alpha,beta-unsaturated aldehyde intermediate with (E)-stereochemistry, followed by the syn addition of water to give product.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the GCKR-like family. MurNAc-6-P etherase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.126" evidence="3"/>
    <dbReference type="EMBL" id="NNBL01000010">
        <property type="protein sequence ID" value="PJN09178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN09178">
        <property type="protein sequence ID" value="PJN09178"/>
        <property type="gene ID" value="CG723_25040"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00342"/>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097367">
        <property type="term" value="F:carbohydrate derivative binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016835">
        <property type="term" value="F:carbon-oxygen lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046348">
        <property type="term" value="P:amino sugar catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097173">
        <property type="term" value="P:N-acetylmuramic acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd05007">
        <property type="entry name" value="SIS_Etherase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00068">
        <property type="entry name" value="MurQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005488">
        <property type="entry name" value="Etherase_MurQ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005486">
        <property type="entry name" value="Glucokinase_regulatory_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040190">
        <property type="entry name" value="MURQ/GCKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001347">
        <property type="entry name" value="SIS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046348">
        <property type="entry name" value="SIS_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10088">
        <property type="entry name" value="PTHR10088"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10088:SF5">
        <property type="entry name" value="PTHR10088:SF5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01380">
        <property type="entry name" value="SIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53697">
        <property type="entry name" value="SSF53697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00274">
        <property type="entry name" value="TIGR00274"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01272">
        <property type="entry name" value="GCKR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51464">
        <property type="entry name" value="SIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="1 3" id="KW-0456">Lyase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SIS" evidence="4">
        <location>
            <begin position="70"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="3">
        <location>
            <position position="98"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PJN09178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="317" mass="32329" checksum="FE390C1402A83721" modified="2018-04-25" version="1">MTSTTDAADNYSELRAQLATLTTEAFRPELSEIDRLSTVEIAQIMNGEDASVPTAVAERLPQIAAAIDGTAERMARGGRLVYAGAGTAGRLGVLDASECPPTFNTDPSEVVGLIAGGPSAMVKAVEGAEDSKELAAEDLDALGLTADDVVVGISASGRTPYAIGAVEHARGRGALTIGLSCNADSALAAAADHGIEVVVGPELLTGSTRLKAGTAQKLVLNMLSTITMIRLGKTYGNLMVDVRASNEKLRARSRRIVALATGADDAAIEAALAATDGEVKNAILVILGSVDGPTAARLLTDSKGHLRAALQASATTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JQT2</accession>
    <name>A0A2M9JQT2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">HAD family hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CG723_24505</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000010">
        <property type="protein sequence ID" value="PJN09236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN09236">
        <property type="protein sequence ID" value="PJN09236"/>
        <property type="gene ID" value="CG723_24505"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041492">
        <property type="entry name" value="HAD_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13419">
        <property type="entry name" value="HAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PJN09236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="263" mass="28737" checksum="CAB703EE9ED6CB2D" modified="2018-04-25" version="1">MVRRPLGNHHHGPDTLLVTSDATKQTVPVAEATESLRELIKRARFVLFDFDGPICRLFAGHSAERVAVEQVRWLEERGLHGLLTEEERAEPDPHAVLRAVDRRRPGSDLVVELEERLTQQELTAVASAWPTQFADPLIRTWFAVGAHLAVTTNNSPAVASRYLATRGLTSCFAPHIYGRTQDLHLLKPHPHCVQRALGALGATPETSLMIGDTPSDFEAATAAGIAFLGYARTDRKAKVLREAGAEVVVSSLEPVLGVLRGRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JQV7</accession>
    <name>A0A2M9JQV7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">EamA family transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CG723_25265</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000010">
        <property type="protein sequence ID" value="PJN09251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN09251">
        <property type="protein sequence ID" value="PJN09251"/>
        <property type="gene ID" value="CG723_25265"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000620">
        <property type="entry name" value="EamA_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00892">
        <property type="entry name" value="EamA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="48"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="81"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="105"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="132"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="156"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="188"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="212"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="246"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="272"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="3">
        <location>
            <begin position="157"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="296"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PJN09251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="322" mass="32323" checksum="F3A2CA1D8B2725BB" modified="2018-04-25" version="1">MAGAPGAPEGATPNGSRWGALGPVGLVLGGCVSVQFGAAVAVSLMPRAGAVGVVTLRLVFAAIVLLIVCRPKLRGHSRADWGTVVAFGVAMGGMNMLFYQAAERIPLGPAVTLEVLGPLALSVFASRRLVNAIWAGLALCGVFLLGGGGFGGLDLVGAAFAVSAGGMWAAYIIFSARTGRRFPQADGLALAMAVAAVLSLPLGIAASGSKLVVPTTMALGAAVAVMSSVLPYTLELLALRRLPASTFAVMMSLEPAIAALAGFLILDQAMSALGALAIALVIAASIGAVRTQVGRGRAKMPEPEAKKVPASGGKRMPAPETE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-06-02" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JQX5</accession>
    <name>A0A2M9JQX5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_25090</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000010">
        <property type="protein sequence ID" value="PJN09187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN09187">
        <property type="protein sequence ID" value="PJN09187"/>
        <property type="gene ID" value="CG723_25090"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="36"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="41"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN09187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="317" mass="32984" checksum="8C8898E8F567A04D" modified="2018-04-25" version="1">MKTGLKITAFAAAVAATFGTAYGVGKGVDPIAAGEQKTAGHAEGGHAEGGRTEEMQDGHAGHGASDTAAAAVPGGLQISERGYTLDLRTRRIAAAGERTELSFAITKDDTGRKVTAYRTEHGKQLHLIVASRDLTVYRHLHPARAADGTWKTPVELPKAGGYRVFADFAPRAEKEGLTLGADLSVAGKYAPRDLPAASRTADAGDGYKVRLGGDLGAGSASELTLTVAKNGRPVTDLQPYLGSYGHLVALRSGDLAYLHVHPNKGGPGPEVSFTATAPSNGTYRLFLDFKHNGTVRTAEFTVHAGQSAGDHSEGHGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JR02</accession>
    <name>A0A2M9JR02_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CG723_23360</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CB01635</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 3">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the GMC oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000009">
        <property type="protein sequence ID" value="PJN09293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN09293">
        <property type="protein sequence ID" value="PJN09293"/>
        <property type="gene ID" value="CG723_23360"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012132">
        <property type="entry name" value="GMC_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000172">
        <property type="entry name" value="GMC_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007867">
        <property type="entry name" value="GMC_OxRtase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552">
        <property type="entry name" value="PTHR11552"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05199">
        <property type="entry name" value="GMC_oxred_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00732">
        <property type="entry name" value="GMC_oxred_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000137">
        <property type="entry name" value="Alcohol_oxidase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00623">
        <property type="entry name" value="GMC_OXRED_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00624">
        <property type="entry name" value="GMC_OXRED_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0274">FAD</keyword>
    <keyword evidence="4" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GMC_OxRdtase_N" evidence="5">
        <location>
            <begin position="91"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="domain" description="GMC_OxRdtase_N" evidence="6">
        <location>
            <begin position="262"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="93"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="230"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000137-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS00623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS00624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PJN09293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="509" mass="53875" checksum="2B1B3F8E590CAFF8" modified="2018-04-25" version="1">MARRIVVCGGGSAGGVLAARLSEDPGNSVTLIEAGPDYRTPEETAPEILDADRIGFTTHDWGYTSTDEVAVADSIPMFGKVDKESVPVLRGKVIGGSSSVNGANALRPTPDDLARWTGLGNDRWSWDQVLPYLKKLEDDPVGGELHGTGGPVHIERFTESSGLRPVQAAFLDACAQAGHRVHQDMNGADQLGAGPLPLNRANGIRQSSALAYLGPARGRANLTVLGERTVDRVEFTEGATARAVLLTDGTRLEADLVVLAAGSIGSPSILMRSGVGPQRILEELSIPVVRALEGVGRNLRDHPMVYLTYQADEEAVGELTPPLQSVLTFAAGGADSGGAVDLHAVLLTMEPGELLVPLVLYRPYSLGSMEIVSRDPDAAPRIGLGLFEHPDDLRRIVSGIRHMRQIMESSPLRKYIKAETWPGPAVTTDADLVRAVLQGKNTCCHAVGTCAMGGEGTSTAVVDQYGKVHGTHGLYVVDASIMPDIPALPTNTTTMMLAERIADDLRVGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JRD4</accession>
    <name>A0A2M9JRD4_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PPM-type phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CG723_21980</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000008">
        <property type="protein sequence ID" value="PJN09450.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN09450">
        <property type="protein sequence ID" value="PJN09450"/>
        <property type="gene ID" value="CG723_21980"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013656">
        <property type="entry name" value="PAS_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13185">
        <property type="entry name" value="GAF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08448">
        <property type="entry name" value="PAS_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07228">
        <property type="entry name" value="SpoIIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00331">
        <property type="entry name" value="PP2C_SIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="SSF81606"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPM-type phosphatase" evidence="1">
        <location>
            <begin position="448"/>
            <end position="664"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PJN09450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="665" mass="71250" checksum="C36F80D7742D6A65" modified="2018-04-25" version="1">MDVSDEFLRGADPAALLTPDGAIRGLNAAMATALGRPAEQCLGLDFAEQCLGGDFGDLLPASQRMSAESLVVQAARSNAVAMRVLEFPGPGGAPVVCLVEARQVKDPAGAEQLVWVHALDARNDLASLLIPFRLATEAADLGLWMYSPHEHQLEWLGGAPSLAALFPDPAVSLSIVISAVHPDNREDLRQLLRSASTQQSTWVKVRYLPQHDAWHQLAAQTRRIQLGYGGPERIFGVVRDDTKQEKRKEKARAALTAERQRARDIADFSSALITAATEQELQQIALTRLAATFDASGALLALVDEGRLRVSTDAGIAMREVDVLHGLPLDHPSALPEAIRTGKPQLILDREDYIRRWPHGAEFPRLGRLGSDYATSITPLSEAGNQPLGAWLVTYRSGYRPSLDQRTLMGTLADLAGQALRRIRLQQARVELATALQKTMLPTLPEHLAGLEVAARYRPSRDGLDIGGDWYDAFVMPDGTVAMEIGDAQGHDVDAAAVMGQVRASMRAIAAHEPDPATVLTRTNELLVTMGAARFASCTMLHIDPGDGRVTGASAGHVPLLCARKDGSHSIHEMAGGPVLGVVSDTEYSEETFTLDEDSALVMVTDGVVEGPSLTLEAGLERAGTLAGAALHDGLNAEETADRVLDASVAVDHLDDVAVLVIRRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2021-04-07" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JRG3</accession>
    <name>A0A2M9JRG3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Replication initiation protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CG723_21965</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000008">
        <property type="protein sequence ID" value="PJN09448.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN09448">
        <property type="protein sequence ID" value="PJN09448"/>
        <property type="gene ID" value="CG723_21965"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PJN09448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="464" mass="50883" checksum="3629D59A2F62FA47" modified="2018-04-25" version="1">MSDAATMAGLDPATLADVLRVAGSPGFDRIQDQIKRTGGCTDPIHLQGSTVTRDRTTGQVLYAYSTDTEPGGRLRVACGNRRASRCPSCAWTYAGDTYHLIRAGLVGDPNKGTPPTVREHPRVFATLTAPSFGPVHNRPGTRPCRCGARHPEDAAELGTPLDPDTYDYAGSVLWNNHASELWRYFTIYLRREIAARVGLTQKAAKEQSRLSFGKVAEYQKRGAIHFHAVIRFDGPEGPDTPPPHWATLALLTDAIHAAAARVRVGLSASGDHRARVLCWGDRLDVQPIKAFGEGAEITEQAVASYVAKYATKAAETTGTVDRRIGNKEALVLLDVPDHPRRLIEACLDLHAAYPDRKLRDWAHMLGFRGHFSTKSRRYSTTLGALRQVRADYRAAQHRAALGLPDPDEIPEETTLTLAHWSYAGHGHTPGESWLAANIRRDITQNRELAREALQDERSSEGADA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JRT6</accession>
    <name>A0A2M9JRT6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CG723_22865</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CB01635</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the four-carbon acid sugar kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000008">
        <property type="protein sequence ID" value="PJN09579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN09579">
        <property type="protein sequence ID" value="PJN09579"/>
        <property type="gene ID" value="CG723_22865"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10840">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.980.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037051">
        <property type="entry name" value="4-carb_acid_sugar_kinase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010737">
        <property type="entry name" value="DUF1537"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031475">
        <property type="entry name" value="NBD_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042213">
        <property type="entry name" value="NBD_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17042">
        <property type="entry name" value="NBD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07005">
        <property type="entry name" value="SBD_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SBD_N" evidence="7">
        <location>
            <begin position="5"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="domain" description="NBD_C" evidence="8">
        <location>
            <begin position="259"/>
            <end position="418"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF07005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF17042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PJN09579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="430" mass="44369" checksum="4CED1883226C5648" modified="2018-04-25" version="1">MSVRLGCIADDFTGATDLANNLVRAGMRVLQLIDVPAEGTDPTTDPTVDADAVVIALKSRTVPAAEAVEASLRALEWLRAAGAEQIYFKYCSTFDSTPAGNIGQVTEALMDALGTDFTVATPAFPDNGRTVFKGHLFVGDVLLGESGMRHHPLTPMTDSNLVSVLDAQTTRPVGLIDHKVVAEGSDAVRARITRLRADGVGAAIVDAVSNDDLLRLGTAVKELPLVTAGSGLAIGLPANWGFEPSPAAAQLPPASGRQAVVAGSVSAATNGQVREFLSTGRPAFSVDPLRIAAGEDVAAEALAFADKYLADGPVLVYSTESPDAVRSVQGQLGAAEAGELVEQTLSRVAQGLIQRDVRQLVVAGGETSGAVVQALGLTSLRIGGQIDPGVPWCAAPLPGGDTLHITLKSGNFGGPDFFTAAFALLNEESK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JS19</accession>
    <name>A0A2M9JS19_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">TetR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CG723_20795</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CB01635</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000007">
        <property type="protein sequence ID" value="PJN09654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN09654">
        <property type="protein sequence ID" value="PJN09654"/>
        <property type="gene ID" value="CG723_20795"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="24"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PJN09654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000232157"/>
        </source>
    </evidence>
    <sequence length="193" mass="20561" checksum="90042C3DD2C0DA20" modified="2018-04-25" version="1">MGHREDLLEGAKRCLLEKGFVRTTARDIVKESGTNLASIGYHYGSKDALLAQAYVALAEGASDDWSAVGELPGAPGSLERFRAVMAGITDSLGKPGAIWHLSIELVTMGDKMPVVREQLAQAQHEAGRGFIGMVMGEEPPVDDPSVQTLGKLFSVLVLGLVAQHTFDADYSPSADELTEGLRLLLDAVRASQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2M9JSE3</accession>
    <name>A0A2M9JSE3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CG723_21590</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. CB01635</name>
        <dbReference type="NCBI Taxonomy" id="2020326"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="0" last="0">
            <title>Discovery of the Leinamycin Family of Natural Products by Mining Actinobacterial Genomes.</title>
            <authorList>
                <person name="Pan G."/>
                <person name="Xu Z."/>
                <person name="Guo Z."/>
                <person name="Ma M."/>
                <person name="Yang D."/>
                <person name="Zhou H."/>
                <person name="Gansemans Y."/>
                <person name="Zhu X."/>
                <person name="Zhao L.-X."/>
                <person name="Jiang Y."/>
                <person name="Cheng J."/>
                <person name="van Nieuwerburgh F."/>
                <person name="Suh J.W."/>
                <person name="Duan Y."/>
                <person name="Shen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CB01635</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNBL01000007">
        <property type="protein sequence ID" value="PJN09790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PJN09790">
        <property type="protein sequence ID" value="PJN09790"/>
        <property type="gene ID" value="CG723_21590"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232157">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045621">
        <property type="entry name" value="BPD_transp_1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19300">
        <property type="entry name" value="BPD_transp_1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
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    <feature type="transmembrane region" description="Helical" evidence="5">
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    <feature type="transmembrane region" description="Helical" evidence="5">
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    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
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    </evidence>
    <evidence type="ECO:0000256" key="3">
   
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